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<entry dataset="TrEMBL" created="2015-01-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A097H0X0</accession>
    <name>A0A097H0X0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">2,3-dihydro-3-hydroxyanthranilate isomerase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Putative trans-2,3-dihydro-3-hydroxyanthranilate isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cnq727</name>
        <name evidence="3" type="ORF">AA958_30780</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="ChemBioChem" volume="15" first="2385" last="2392">
            <title>A Membrane-Bound Prenyltransferase Catalyzes the O-Prenylation of 1,6-Dihydroxyphenazine in the Marine Bacterium Streptomyces sp. CNQ-509.</title>
            <authorList>
                <person name="Zeyhle P."/>
                <person name="Bauer J.S."/>
                <person name="Steimle M."/>
                <person name="Leipoldt F."/>
                <person name="Rosch M."/>
                <person name="Kalinowski J."/>
                <person name="Gross H."/>
                <person name="Heide L."/>
            </authorList>
            <dbReference type="PubMed" id="25224759"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CNQ-509</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KJ451627">
        <property type="protein sequence ID" value="AIT42117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019100.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_30780"/>
    <dbReference type="EnsemblBacteria" id="AKH85872">
        <property type="protein sequence ID" value="AKH85872"/>
        <property type="gene ID" value="AA958_30780"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_30780"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6506"/>
    <dbReference type="OrthoDB" id="1468060at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003719">
        <property type="entry name" value="Phenazine_PhzF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13774">
        <property type="entry name" value="PTHR13774"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02567">
        <property type="entry name" value="PhzC-PhzF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016184">
        <property type="entry name" value="PhzC_PhzF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00654">
        <property type="entry name" value="PhzF_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="1">
        <location>
            <position position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR016184-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIT42117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH85872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="279" mass="29875" checksum="E1FD92247F0EFDA3" modified="2015-01-07" version="1">MPELDYMLVDAFSRKPLSGNPVAVFLDARELTPDLMQRIAREMNLSETTFVLPPGEGGDARIRIFTPVNELPFAGHPLLGTAVALGETRKQDELQLETAMGVIPVHLTDDDGAVKVSMRQPHPVWEPYAEADELLAALGADTSVAPVEVYRNGPRHVFVGLESVPALSALRPDHRALSEFPDMAANCFAGQGRQWRARMFSPAYGVVEDAATGSAAGPLAIHLARHGLAAYGEQVEILQGVEMGRPSLMLATAEGDGDRIHAVHVGGNGVTVGRGTLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MXF1</accession>
    <name>A0A0F7MXF1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SH3b domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_00585</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH80910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014276.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH80910">
        <property type="protein sequence ID" value="AKH80910"/>
        <property type="gene ID" value="AA958_00585"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_00585"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.137"/>
    <dbReference type="OrthoDB" id="1996989at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003646">
        <property type="entry name" value="SH3-like_bac-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08239">
        <property type="entry name" value="SH3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002518904" description="SH3b domain-containing protein" evidence="1">
        <location>
            <begin position="31"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="SH3b" evidence="2">
        <location>
            <begin position="66"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH80910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="131" mass="13849" checksum="BEA1F88B2D3DC2AA" modified="2015-07-22" version="1">MSIRKAAAALVATAALTLGALATTPSLAAADSEGQKAQAAPAAPAGQANPYPYRGKVLGNSVVYKRAKPTTRSDILGWADSGTIVRIQCKVIGQNVLGNNRWYRVPVRGGGYGYMSARYVLNLDRIPFCRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MYR8</accession>
    <name>A0A0F7MYR8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2Fe-2S ferredoxin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_00415</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the xanthine dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH80881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014247.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH80881">
        <property type="protein sequence ID" value="AKH80881"/>
        <property type="gene ID" value="AA958_00415"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_00415"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.98"/>
    <dbReference type="OrthoDB" id="117507at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002888">
        <property type="entry name" value="2Fe-2S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036884">
        <property type="entry name" value="2Fe-2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000674">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036856">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016208">
        <property type="entry name" value="Ald_Oxase/xanthine_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008274">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037165">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11908">
        <property type="entry name" value="PTHR11908"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01315">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02738">
        <property type="entry name" value="Ald_Xan_dh_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01799">
        <property type="entry name" value="Fer2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01008">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47741">
        <property type="entry name" value="SSF47741"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF56003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="3">
        <location>
            <begin position="786"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="603"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="931"/>
            <end position="957"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH80881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="957" mass="99993" checksum="F223965DF69FC485" modified="2015-07-22" version="1">MGKDQRQARGPGAVGVSLPRLDAVPKVTGAAEYGVDVAPPGALTARVLTSPLPAARIRRLDTRRARRVPGVRAVVTGADWPRRHGPFVRDQPALALDQVRHYGEVVAAVAAETEEAAAEAVEQIEVEYEPLPALLTPDQALADDARLIHPDWQHYELTGALGIRFDPHGNSPFRFRLRTGDAEAGLAAADVVVEDTYTTSFVQHAHLEPHAVVARFDSAGALTVWQATPGPHTLRAMLAELCDLPLNKVTVRVPYVGGAFGAKMYLRALNPAAVLLARRVPGRPVRLVFTRVQEFTSATGRMPMRIRMRTGARRDGTLTVREVTIVGEQGAYADAAPLILRNCGYGSPGPYRIPHVRVDARLAYTNRLPAGAMRGLGTPQTCWAGEQQIDTLAAELGIGPLELRRHNLLRDGDVSATGEVMRDVGAGACLDAVAARTRPGTEPGDGRRPGGGAAGMRRATGYALAWKSALAPAVSFATVRLLHDGSAEVACAAIDNGQGARTIMAQIAAAALSLPPGRIHLADPGTSSPSFDRGSTASRTTFAVGGAVQAAAQSVADQLRAIAAAEFHATEGEVVMAQGTIGARGRHLSYAALLTRHFEGPGELLGHGRTGHGTTTPIDPHTGRSTRPTPFWSYAAAAVTIGIEAVTGRITSAGLTVAVDAGSAVNPLACEQQVIGAALQGWGMATTERVDFSTGRPDVEGLGAYRIPTMTDAPGIEAVVVETPTADGPAGGARGIGEIGLVPVPAALGNALHAATGTRHTALPLPAHLVPERPGPAGQPPASAPGPLTVNGREPAEIPPGMSLLRLLRERLALTGAKAGCDAEGVCGTCTVLLDGQPLRACRTTATRIGGEVRTVEDLARHGELSRLQRTFVDHGAVQCGYCTPGMLMAATALLERTPRPSRDQVRRHLAGNLCRCGAYAHIVDAVLAAADTPSPPPATEGSDARSGSTRPDEERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MYX3</accession>
    <name>A0A0F7MYX3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_03845</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014822.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_03845"/>
    <dbReference type="EnsemblBacteria" id="AKH81465">
        <property type="protein sequence ID" value="AKH81465"/>
        <property type="gene ID" value="AA958_03845"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_03845"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.808"/>
    <dbReference type="OrthoDB" id="744602at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="5">
        <location>
            <begin position="17"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="243"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH81465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="468" mass="48352" checksum="4443468698049631" modified="2015-07-22" version="1">MAASAPAAPAPPAAPHEHTVVNPATEEAVATVPAAGPKEVAAAVARAAGAQRGWAALAPGDRARLLRRFAAEVDARIEELARLEVTEAGHPVAAARWEAGNVRDLLDYAAGGVERLTGSQIPVAGGLNVTFAEPLGVVGVIAPWNFPMPIAAWGTAPALAAGNAVVLKPAEATPLTALRLAELALEAGLPEGLFQVVPGAGPVAGAALVDHPDVAKVVFTGSTAVGKRIAARCAEQVKRVTLELGGKSPNIVFADADLERAAAAAPASFLDNTGQDCCARSRILVQRSVYDRFLALLEPAVLAFTAGDPADSGTRMGPLISAAHRERVRGHVPESRPAAIRGTVPEGPGYWYPATVLTDAPPDDPVSREEVFGPVAVVHPFDDEADAVRLANAGPYGLSGSLWTRDTARAVRVSRAVAAGNLSVNSHSSVRYWTPFGGFKQSGLGRELGPDALASFTETKNVFISTEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MZ24</accession>
    <name>A0A0F7MZ24_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Adenylosuccinate lyase</fullName>
            <shortName evidence="10">ASL</shortName>
            <ecNumber evidence="4 10">4.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 10">Adenylosuccinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AA958_00980</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + fumarate</text>
            <dbReference type="Rhea" id="RHEA:23920"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:58443"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="EC" id="4.3.2.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:23921"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N(6)-(1,2-dicarboxyethyl)-AMP = AMP + fumarate</text>
            <dbReference type="Rhea" id="RHEA:16853"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:57567"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="4.3.2.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:16854"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.2" evidence="4 10"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH80976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014342.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_00980"/>
    <dbReference type="EnsemblBacteria" id="AKH80976">
        <property type="protein sequence ID" value="AKH80976"/>
        <property type="gene ID" value="AA958_00980"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_00980"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.217"/>
    <dbReference type="OrthoDB" id="347727at2"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00132"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00075">
        <property type="reaction ID" value="UER00336"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070626">
        <property type="term" value="F:(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004018">
        <property type="term" value="F:N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019468">
        <property type="entry name" value="AdenyloSucc_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004769">
        <property type="entry name" value="Pur_lyase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10397">
        <property type="entry name" value="ADSL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00998">
        <property type="entry name" value="ADSL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00928">
        <property type="entry name" value="purB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 10" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADSL_C" evidence="11">
        <location>
            <begin position="371"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AKH80976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="479" mass="51889" checksum="22B8B8DCD94A267B" modified="2015-07-22" version="1">MNKPRIPNVLAARYASAELAALWSPEHKVVLERQLWLAVLRAQRELGIEVPEGAVADYERVLEDVDLASIAEREKVTRHDVKARIEEFNALAGHEQIHKGMTSRDLTENVEQLQVRQSLELVRDRAVAVLARLGRLAGEHAGLVMAGRSHNVAAQATTLGKRFATAADELLTAYGRVEDLLTRYPLRGVKGPVGTAQDMLDLLGGGNEGAAKLAELERRVAGHLGFARAFTSVGQVYPRSLDYDVVAALVQVAAAPSSLAKTIRLMAGHELVTEGFKPGQVGSSAMPHKMNTRSCERVNGLMVILRGYASMTAELAGDTWNEGDVSCSVVRRVALPDAFFALDGLLETFLTVLDEFGAFPAVIARELDRYLPFLATTKVLMAAVRAGVGREEAHEVVKEHAVAAALAMRERGAERNELLDRLAADARIPLDRDRLEALMADRLSFTGAAEEQVAAVAARVEEVVKRHPEAAGYAPGAIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MZ79</accession>
    <name>A0A0F7MZ79_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glycoamylase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_01335</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014396.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_01335"/>
    <dbReference type="EnsemblBacteria" id="AKH81031">
        <property type="protein sequence ID" value="AKH81031"/>
        <property type="gene ID" value="AA958_01335"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_01335"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.295"/>
    <dbReference type="OrthoDB" id="1384939at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019282">
        <property type="entry name" value="Glycoamylase-like_cons_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10091">
        <property type="entry name" value="Glycoamylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002518916" description="Glycoamylase-like domain-containing protein" evidence="1">
        <location>
            <begin position="30"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoamylase-like" evidence="2">
        <location>
            <begin position="278"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH81031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="488" mass="53843" checksum="042FD6AC91B58AB4" modified="2015-07-22" version="1">MDRRTFLAAAAVTAGAAGSAGLGAAPGHAAVRSPQDPEPVLTGWFRDTYRSLDAMVADNGLPADNIDLSGGEPVLTENTSVTNIGCWIWSTVAAAGLGVISEREMHARLARTVSTIERMKRIHGFWFNWYHTFTGEVLDEWPGSGAPVDHLLSTVDNGWLDVALRIAEDADPLLRGRIRKLRKDIDWSFMYVPYDPADPVARPGHMSTGFRVADDALTPHFYGALVSETRIAGYLGIADGTVPGDHYWHMLRTFTPDQAQEMPPGGDWVVRDGVRYFNGHYTYRGRRHAPGWGGSMFGALMPELFVPSAQWSPSWRTNLTHHVQGHRDHGLLDAEYGYWGFSPANVPEGGYQEYGVQYFGISPEGYCSNTDRTYVPYGEPKPDPSAYTNGVVTPHAAAMALMVAPRYAFDNLRRIARDFDAYEDGYGFYDSVNVGTGRVSDRMLSLDQGMFAAALAQVLRPGLLQRPFRTGGFRRTLKPLLAKEDFGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MZS3</accession>
    <name>A0A0F7MZS3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AA958_02330</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014565.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH81201">
        <property type="protein sequence ID" value="AKH81201"/>
        <property type="gene ID" value="AA958_02330"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_02330"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.500"/>
    <dbReference type="OrthoDB" id="643917at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="292"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="8">
        <location>
            <begin position="35"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="324"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="584"/>
            <end position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH81201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="615" mass="63792" checksum="6064A0F4C9C32414" modified="2015-07-22" version="1">MQLRDLPHTDPGEPDVRSGRHFLVWLGRMQLGGQVAALLWGLVWMLPLGAMPLAVGMAVQAVVDRNGGRLAVAGALLIAFGALMALGDSMLHRAAVTNWITAASRVQQLLARKAADLGSILTRRVAAGEVVAVSTGDVEKIGWFVESFSRFTAALFTALAVTAGLVVYAPELGLLVAVALPVLALAPLPLLPYATRRADDQRAKAGRATELAADTVAGLRVLRGIGGEELFLDRYREASQKVRTAAVRSARMWALIHAVQVALPGVLLVVVVGHGAGLARNGTITVGELVTVYGAVTFLLFPMHHFAELAMAYSFSRPSAKRAARVLGLARTTTGGTGTDHGPLGGELHDPATGLRAAAGRMTAVVCGDPDAAGRLADRLGGHPAEPGELPSVRLGGVELDDVPLAGARAAVLVQDKDPMLLSGTLADLLDVPASGSVKPAAALAAAQCGDVLTALAQAAAAAPDGDGAPMGAPMGAPITERGRSLSGGQRQRLALARSLVADPEVLVLDEPTSAVDSHTEARIAESLREIRAGRTTVVFTSSPLLLDRADTVVFVQDGTVLAEGPHRELLHGDVAYRTVVTRETDGEKQAGRVPEGDPAVRGEGGVPQMMEETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N092</accession>
    <name>A0A0F7N092_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Vitamin K epoxide reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">AA958_03240</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VKOR family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014715.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_03240"/>
    <dbReference type="EnsemblBacteria" id="AKH81356">
        <property type="protein sequence ID" value="AKH81356"/>
        <property type="gene ID" value="AA958_03240"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_03240"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.690"/>
    <dbReference type="OrthoDB" id="1932901at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12922">
        <property type="entry name" value="VKOR_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012932">
        <property type="entry name" value="VKOR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041714">
        <property type="entry name" value="VKOR_Actinobacteria"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038354">
        <property type="entry name" value="VKOR_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07884">
        <property type="entry name" value="VKOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00756">
        <property type="entry name" value="VKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0874">Quinone</keyword>
    <keyword evidence="9" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="VKc" evidence="12">
        <location>
            <begin position="25"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AKH81356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="213" mass="23826" checksum="CA41243C64FB017A" modified="2015-07-22" version="1">MTTTATRTAPSQHEDPPDSGLIGSGRPFAWLLVIGGVLGLVASAVITHDKMKLLEDPDYVSACSLNPVLSCNNIMKSWQASVFGFPNPFVGWIAFPMLVVIGVGLLSGATHRRWWWTGLWAGSLFGVGFVTFLQYSSLYKIGSLCLWCSLVWAVTILIFWYTTVHNVKTGVFPVSARVRETVLEFNWVVPVLWYGILLILIGIRWWSYWKTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0T5</accession>
    <name>A0A0F7N0T5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent dethiobiotin synthetase BioD</fullName>
            <ecNumber evidence="5">6.3.3.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">DTB synthetase</fullName>
            <shortName evidence="5">DTBS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Dethiobiotin synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">bioD</name>
        <name evidence="6" type="ORF">AA958_00940</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(7R,8S)-7,8-diammoniononanoate + ATP + CO2 = (4R,5S)-dethiobiotin + ADP + 3 H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15805"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:149469"/>
            <dbReference type="ChEBI" id="CHEBI:149473"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the dethiobiotin synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.3.3" evidence="5"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH80969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014335.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_00940"/>
    <dbReference type="EnsemblBacteria" id="AKH80969">
        <property type="protein sequence ID" value="AKH80969"/>
        <property type="gene ID" value="AA958_00940"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_00940"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.208"/>
    <dbReference type="OrthoDB" id="1739932at2"/>
    <dbReference type="UniPathway" id="UPA00078">
        <property type="reaction ID" value="UER00161"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004141">
        <property type="term" value="F:dethiobiotin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00336">
        <property type="entry name" value="BioD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004472">
        <property type="entry name" value="DTB_synth_BioD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43210">
        <property type="entry name" value="PTHR43210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006755">
        <property type="entry name" value="DTB_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
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</entry>
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                <person name="Kalinowski J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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        <source>
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    <sequence length="223" mass="23977" checksum="F937263AD5EDA290" modified="2015-07-22" version="1">MSATPPAAYRPTDRTVPTRSRERASYDRAVVHSVLDAGYVCHLGFLREGRPVVLPTLYARVGEQVYVHGSTGSRPLRTAGRAEDAGLPVCLTVTHVDGLVLARSAFHHSINYRSAMLHGDAYAVTDHDERTMALDAIVDHIVPGRADDSRRANAKELAKTAVLRLAIEEVSVKTRTGGPEDEPEDLELPYWTGVVPVAPVYGAPVPAADLAPGVEPPGYLPAD</sequence>
</entry>
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                <person name="Kalinowski J."/>
                <person name="Heide L."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">CNQ-509</strain>
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        </location>
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    </evidence>
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        <source>
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    </evidence>
    <sequence length="180" mass="18655" checksum="E1BF13CF6773DF40" modified="2015-07-22" version="1">MAKLLYSATMSLDGFIAGPGGDMSWLAGHLGDNPTVDGLVPRVGSILSGARSFFGDDPHRGTENEGEAFGGGWEGQQFVLTHHPPAEPVPGVTFGADLGTAVTAAKAAAGDGYVNVIGADVARQCIEAGLLDEVLVFTAPVFLGDGVRLFDRPGGTRVLLEQVQVSALRHCTGIWLRVVG</sequence>
</entry>
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        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Albersmeier A."/>
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                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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        <property type="gene ID" value="AA958_02365"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="1811015at2"/>
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    </dbReference>
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        <property type="entry name" value="DUF742"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36221">
        <property type="entry name" value="PTHR36221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05331">
        <property type="entry name" value="DUF742"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH81208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="139" mass="15049" checksum="E3A0D46546FB5B7A" modified="2015-07-22" version="1">MTEDMSGTPPHHGSHWYDAEAGPLVRPYAMTGGRTRPVTTTVRFDLIALIDLEEEALEAAGKEAGTFGPEHRALIDLCRIETQSVAELAAETDLPVGVVRVLLGDLVELGCVRVSRPVPPAQLPDEMILREVIDGLRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N1M6</accession>
    <name>A0A0F7N1M6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cys-tRNA(Pro)/Cys-tRNA(Cys) deacylase</fullName>
            <ecNumber evidence="3">4.2.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_06410</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the prolyl-tRNA editing family. YbaK/EbsC subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.-.-" evidence="3"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015254.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_06410"/>
    <dbReference type="EnsemblBacteria" id="AKH81901">
        <property type="protein sequence ID" value="AKH81901"/>
        <property type="gene ID" value="AA958_06410"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_06410"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1338"/>
    <dbReference type="OrthoDB" id="1503081at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00002">
        <property type="entry name" value="YbaK_deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.960.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004369">
        <property type="entry name" value="Prolyl-tRNA_editing_YbaK/EbsC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036754">
        <property type="entry name" value="YbaK/aa-tRNA-synt-asso_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007214">
        <property type="entry name" value="YbaK/aa-tRNA-synth-assoc-dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04073">
        <property type="entry name" value="tRNA_edit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006181">
        <property type="entry name" value="EbsC_YbaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55826">
        <property type="entry name" value="SSF55826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00011">
        <property type="entry name" value="YbaK_EbsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA_edit" evidence="4">
        <location>
            <begin position="33"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR006181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH81901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="165" mass="16523" checksum="653F275B8B0357AC" modified="2015-07-22" version="1">MAKKKQAGSTPATVALTQAGAEFTVHAYAHDPAAASYGEEAAEALGVDPGQVFKTLVAEVDGALTVAIVPVSGALDLKALAAAAGGKKAVMADPAHAERTTGYVRGGISPLGQRKRLPTVLDSSAAGRPTVCVSAGRRGLEVELSPTVLAELTGAVVAPIARDGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N1N9</accession>
    <name>A0A0F7N1N9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">Cell division protein FtsZ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ftsZ</name>
        <name evidence="11" type="ORF">AA958_06520</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="6">Assembles at midcell at the inner surface of the cytoplasmic membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the FtsZ family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015273.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_06520"/>
    <dbReference type="EnsemblBacteria" id="AKH81921">
        <property type="protein sequence ID" value="AKH81921"/>
        <property type="gene ID" value="AA958_06520"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_06520"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1361"/>
    <dbReference type="OrthoDB" id="1009041at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043093">
        <property type="term" value="P:FtsZ-dependent cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051258">
        <property type="term" value="P:protein polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02201">
        <property type="entry name" value="FtsZ_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00909">
        <property type="entry name" value="FtsZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000158">
        <property type="entry name" value="Cell_div_FtsZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020805">
        <property type="entry name" value="Cell_div_FtsZ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045061">
        <property type="entry name" value="FtsZ/CetZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024757">
        <property type="entry name" value="FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30314">
        <property type="entry name" value="PTHR30314"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12327">
        <property type="entry name" value="FtsZ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00423">
        <property type="entry name" value="CELLDVISFTSZ"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="SSF52490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="SSF55307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00065">
        <property type="entry name" value="ftsZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01134">
        <property type="entry name" value="FTSZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01135">
        <property type="entry name" value="FTSZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 6 7" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0717">Septation</keyword>
    <feature type="domain" description="Tubulin" evidence="9">
        <location>
            <begin position="10"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin_C" evidence="10">
        <location>
            <begin position="204"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="320"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="18"/>
            <end position="22"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="105"/>
            <end position="107"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AKH81921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="404" mass="41310" checksum="9133A68FA3ACED54" modified="2015-07-22" version="1">MAAPQNYLAVIKVVGIGGGGVNAINRMIEVGLKGVEFIAINTDAQALLMSDADVKLDVGRELTRGLGAGANPDVGRKAAEDHREEIEEVLKGADMVFVTAGEGGGTGTGGAPVVANIARSLGALTIGVVTRPFTFEGRRRANQAEDGIAALRDEVDTLIVIPNDRLLSISDRQVSVLDAFRSADQVLLSGVQGITDLITTPGLINLDFADVKSVMSEAGSALMGIGSARGDDRAVAAAEMAISSPLLEASIDGARGVLLSISGGSDLGLFEINEAAQLVSEAAHPEANIIFGAVIDDALGDEVRVTVIAAGFDGGQLPSKNRDKVLGSYGGRDEAPAESVADPGPARSTEPERPAFGGLGSLSGDSTADSAPAPVPPAATPQVPAARPYQDSEAEELDVPDFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N1Y6</accession>
    <name>A0A0F7N1Y6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">(5-formylfuran-3-yl)methyl phosphate synthase</fullName>
            <ecNumber evidence="3">4.2.3.153</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">4-(hydroxymethyl)-2-furancarboxaldehyde-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_00285</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the formation of 4-(hydroxymethyl)-2-furancarboxaldehyde phosphate (4-HFC-P) from two molecules of glyceraldehyde-3-P (GA-3-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 D-glyceraldehyde 3-phosphate = 4-(hydroxymethyl)-2-furancarboxaldehyde phosphate + 2 H2O + phosphate</text>
            <dbReference type="Rhea" id="RHEA:43536"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:83407"/>
            <dbReference type="EC" id="4.2.3.153"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="4.2.3.153" evidence="3"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH80862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014228.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_00285"/>
    <dbReference type="EnsemblBacteria" id="AKH80862">
        <property type="protein sequence ID" value="AKH80862"/>
        <property type="gene ID" value="AA958_00285"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_00285"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.67"/>
    <dbReference type="OrthoDB" id="1796491at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007565">
        <property type="entry name" value="4HFCP_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04476">
        <property type="entry name" value="4HFCP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015957">
        <property type="entry name" value="UCP015957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0704">Schiff base</keyword>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="7">
        <location>
            <position position="29"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR015957-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH80862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="251" mass="26075" checksum="357B4DF0C67F1579" modified="2015-07-22" version="1">MLLLISPDGVEEALDCAKAAEHLDIVDVKKPDEGSLGANFPWVIREIRDAVPADKPVSATVGDVPYKPGTVAQAALGAVVSGATYIKVGLYGCTTPDQGIEVMRAVVRAVKDHRPDALVVASGYADAHRIGCVNPLAVPDIAARSGADAAMLDTAVKDGTRLFDHVLPDVCAEFVRLAHASGRLAALAGSVTQADLGPLTRIGTDIVGVRGAVCEGGDRNTGRIQPHLVAAFRAEMDRHAAEHTVGVSSVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N232</accession>
    <name>A0A0F7N232_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Phenylalanine--tRNA ligase beta subunit</fullName>
            <ecNumber evidence="14">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Phenylalanyl-tRNA synthetase beta subunit</fullName>
            <shortName evidence="14">PheRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">pheT</name>
        <name evidence="19" type="ORF">AA958_03775</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + H(+) + L-phenylalanyl-tRNA(Phe)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="14">Binds 2 magnesium ions per tetramer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 14">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="14"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014811.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_03775"/>
    <dbReference type="EnsemblBacteria" id="AKH81453">
        <property type="protein sequence ID" value="AKH81453"/>
        <property type="gene ID" value="AA958_03775"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_03775"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.794"/>
    <dbReference type="OrthoDB" id="53568at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00769">
        <property type="entry name" value="PheRS_beta_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02796">
        <property type="entry name" value="tRNA_bind_bactPheRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00283">
        <property type="entry name" value="Phe_tRNA_synth_beta1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005146">
        <property type="entry name" value="B3/B4_tRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005121">
        <property type="entry name" value="Fdx_antiC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036690">
        <property type="entry name" value="Fdx_antiC-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045060">
        <property type="entry name" value="Phe-tRNA-ligase_IIc_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004532">
        <property type="entry name" value="Phe-tRNA-ligase_IIc_bsu_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020825">
        <property type="entry name" value="Phe-tRNA_synthase-like_B3/B4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041616">
        <property type="entry name" value="PheRS_beta_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002547">
        <property type="entry name" value="tRNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033714">
        <property type="entry name" value="tRNA_bind_bactPheRS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005147">
        <property type="entry name" value="tRNA_synthase_B5-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10947">
        <property type="entry name" value="PTHR10947"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03483">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03484">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03147">
        <property type="entry name" value="FDX-ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01588">
        <property type="entry name" value="tRNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17759">
        <property type="entry name" value="tRNA_synthFbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00873">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00874">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00896">
        <property type="entry name" value="FDX-ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54991">
        <property type="entry name" value="SSF54991"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00472">
        <property type="entry name" value="pheT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51483">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51447">
        <property type="entry name" value="FDX_ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50886">
        <property type="entry name" value="TRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 14 19" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="9 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="10 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12 14" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 15" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="TRNA-binding" evidence="16">
        <location>
            <begin position="42"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="B5" evidence="18">
        <location>
            <begin position="419"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="FDX-ACB" evidence="17">
        <location>
            <begin position="747"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="471"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="477"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="480"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="481"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="AKH81453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="842" mass="89746" checksum="86D3086A61130FF9" modified="2015-07-22" version="1">MRVPLSWLREYVDLPAGETGRAVQARLISAGLEVETVERLGAGLTGPLVVGRVLAIEELTEFKKPIRYCQVDVGQAGGTGEPQNIICGASNFAVGDKVVVILPGGELPGGFKIGARKTYGKVSEGMICSVRELGIGDDHDGILVLPPEYEPGTDAIELLELNDEVLDIAVNPDRGYALSLRGVARETAIAYGLPLRDPALLDVPPPNDYGYPVKVDDLRGCDRFTARVVTGIDPEARSPIWLQRRLQKAGMRPISLAVDVTNYVMLEIGQPLHAYDRDRLDGPLGVRRAAPGEKLTTLDGVERTLDPGDLLITDNRGPIGLAGVMGGADTEIAEAGVRDHLLGAVAGTTDIVIEAAHFDPVSIARTSRRHRLTSEASRRFERGVDPEAGPAAAQRTVDLLVLLAGGSAEAGVTGVTAPRGPRTVRMKADHPDLVAGVTYGRDTVVRRLQEVGCDVYGADELTVTVPSWRPDLGSPNDLAEEVIRLEGYENLPSTLPRPPAGRGLTGRQRLHRRVGRVLAGAGYVEVLNYPFVGEAALDALGLEPDDARRRTVTLVNPLSDEEPALRTTLLPGLLAALRRNHGRGAADLALFETGLVFRPSGYETAPVRLPVDRRPTDEEIARLDTALPKQPRRAAVVLAGARERAGWWGRGRPADWADAVEAARTVAREAGVELAAESDRHAPWHPGRCAALFAVVDGERRVVGHAGELHPRVVKAMQLPERTCAMEVSLDLLEIAGGGPLQAPRISTYPVATQDVALVVAADVPAAKVAAALRAGAGELLESVRLFDVFTGEQVGEGRKSLAYALRFRAADRTLTAEEAGEARAAAVARAAEETGAVLRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N255</accession>
    <name>A0A0F7N255_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-phosphate glycerol 3-phosphate acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_00835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH80952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014318.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_00835"/>
    <dbReference type="EnsemblBacteria" id="AKH80952">
        <property type="protein sequence ID" value="AKH80952"/>
        <property type="gene ID" value="AA958_00835"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_00835"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.187"/>
    <dbReference type="OrthoDB" id="1756450at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PlsC" evidence="1">
        <location>
            <begin position="35"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH80952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="235" mass="26030" checksum="373E963E0FC7987F" modified="2015-07-22" version="1">MFYHLLKYLFFGPLLRPLFRPRIEGLEHIPEEGAAIVAGNHLSFADHFLMPVMLKRRITFLAKAEYFNGPGLKGRLTAGFFHSIGQIPVDRRGRKAAQAAIEEGLAVLAKGELLGIYPEGTRSHDGRLYKGRVGVAAMALRAGVPVIPCAMIGTREVQPPGQKLPSLGRVTIRFGEPLEFSRYEGMEDHKAVLRAVTDEIMYAILSMSDQEYVDRYAQEVKAEQEAAKKKPPAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2E2</accession>
    <name>A0A0F7N2E2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transketolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_04365</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014903.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_04365"/>
    <dbReference type="EnsemblBacteria" id="AKH81548">
        <property type="protein sequence ID" value="AKH81548"/>
        <property type="gene ID" value="AA958_04365"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_04365"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.917"/>
    <dbReference type="OrthoDB" id="188169at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016744">
        <property type="term" value="F:transketolase or transaldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd02012">
        <property type="entry name" value="TPP_TK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020826">
        <property type="entry name" value="Transketolase_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00802">
        <property type="entry name" value="TRANSKETOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Transket_pyr" evidence="7">
        <location>
            <begin position="309"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH81548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="623" mass="65143" checksum="29A4D5C6D58B8883" modified="2015-07-22" version="1">MTSVDVDPDLSLALGRQLRVDAIRAAAAAGSGHPTSSMSAADLMAVLLARHLRYDVDRPDHPGADHLVLSKGHASPLLYAAFKAVGAVDDEELLTFRKLGSRLEGHPTPMLPWVDVATGSLGQGPPIGVGMALAGKRLAHLPYRVWVLCGDSELSEGSVWEAFEHAGYEHLGNLTVIVDVNRLGQRGPTRHGWDLDAYARRARAFGWHTIEVDGHDVAAVDAAYSEAADVADRPTVVLARTVKGSGVASVANREGMHGKPLPDPEAAIAELGGTGDLRVEPHTPPPAVAPPRAAAPRPLLPRYDVGDPVATRDAYGQALAALGTARPDVVALDGEVGDSTRTELFAKEHPDRYFECYIAEQQLVAAGVGMQACGWMPFAATFAAFFTRAHDFVRMAAVSRANLSLVGSHAGVAIGEDGPSQMGLEDLAMFRAVHGSTVLHPCDANQTARLVAAMAGEELTGVRYLRTMRGARPVLYGPDEDFPIGGSKLLRATPGDSVTIAAAGVTVHEALVAAELLAAEGIGAHVLDLYSVKPIDVVALRAAAELTGRILTVEDHRPEGGLGDAVAEAFADGRAVPRLARLAVRTMPGSATGAQQLSAAGIDAEAIAAAARNLVDAEAARPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2K7</accession>
    <name>A0A0F7N2K7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AA958_04820</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014983.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_04820"/>
    <dbReference type="EnsemblBacteria" id="AKH81628">
        <property type="protein sequence ID" value="AKH81628"/>
        <property type="gene ID" value="AA958_04820"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_04820"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1015"/>
    <dbReference type="OrthoDB" id="760677at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="23"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="139"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="242"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH81628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="396" mass="42513" checksum="5B2EE783EAD2B923" modified="2015-07-22" version="1">MGSSTTPPFNPADPLGVDDLLGPEDIAVRDTVRGWAADRVLPHIADWYERGELPGIRELARELGAMGALGMSLTGYGCAGASAVQYGLACLELEAADSGIRSLVSVQGSLAMYAIWRFGSEEQKQRWLPRMATGEVIGCFGLTEPDHGSDPAGMRTYAKRDGSDWVLTGRKMWITNGSVAGVAVVWARTDDGIRGFAVPTDAPGFSAPEIRHKWSLRASVTAELVLDEVRLPADAVLPEATGLRGPLSCLTHARYGIVWGAMGAARASFDAALDYARTREQFGKPIGGFQLTQAKLADMAVELHKGVLLAHHLGTRMDAGTLRPEQVSFGKLNNVREAIEICRTARTILGANGISLEYPVMRHATNLESVLTYEGTVEMHQLVLGKALTGLDAFRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2Z4</accession>
    <name>A0A0F7N2Z4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_13100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016342.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_13100"/>
    <dbReference type="EnsemblBacteria" id="AKH83010">
        <property type="protein sequence ID" value="AKH83010"/>
        <property type="gene ID" value="AA958_13100"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_13100"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2756"/>
    <dbReference type="OrthoDB" id="1498437at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="56"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH83010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="307" mass="34002" checksum="5857B540FEB04605" modified="2015-07-22" version="1">MVRRINVPGAGGLRLAAWEYGDPPKRGAEGIAARSRSAAGLAGGPPGPAPQDRPGVLLLHGLMGRGSHWATTARWLSARARAIALDQRGHGRSDKPGDGPFDREAYIADAEAVIEQLDLVPVVLVGHSMGALTAWQLAARRPDLVRALVICDMRASALGAASQREWEEWFRSWPTPFATLADVRKWFGEDDPILERPRPARGEFFAEVMAERADGWRPVFSRRQMLRARETWVHDAHWEELALVRCPALVIRGIDGELGRAEAQEMVRVLPRGEYAELEAGHLLHLEDPDAFHRAIEPFLEKVLTPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N331</accession>
    <name>A0A0F7N331_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongation factor 4</fullName>
            <shortName evidence="5">EF-4</shortName>
            <ecNumber evidence="5">3.6.5.n1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Ribosomal back-translocase LepA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">lepA</name>
        <name evidence="7" type="ORF">AA958_09390</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>GTP + H2O = GDP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.n1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.n1" evidence="5"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015752.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_09390"/>
    <dbReference type="EnsemblBacteria" id="AKH82406">
        <property type="protein sequence ID" value="AKH82406"/>
        <property type="gene ID" value="AA958_09390"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_09390"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1982"/>
    <dbReference type="OrthoDB" id="182107at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03709">
        <property type="entry name" value="lepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00071">
        <property type="entry name" value="LepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006297">
        <property type="entry name" value="EF-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038363">
        <property type="entry name" value="LepA_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013842">
        <property type="entry name" value="LepA_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035654">
        <property type="entry name" value="LepA_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43512">
        <property type="entry name" value="PTHR43512"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06421">
        <property type="entry name" value="LepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01393">
        <property type="entry name" value="lepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="6">
        <location>
            <begin position="17"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="29"/>
            <end position="34"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="150"/>
            <end position="153"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH82406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="621" mass="68485" checksum="AF00B9864419BC27" modified="2015-07-22" version="1">MPATETTVPQPSRTEPALIRNFCIIAHIDHGKSTLADRMLQITGVVDKRQMREQYLDRMDIERERGITIKSQAVRMPWSPSGGESSGRAHILNMIDTPGHVDFTYEVSRSLAACEGCVLLVDAAQGIEAQTLANLYLAMENDLTIIPVLNKIDLPAAQPEKFAAELAGLIGCDPSDVLRVSAKTGEGVEALLDEVVRQVPAPVGVKDAPARAMIFDSVYDSYRGVVTYVKVVDGTLGKRERIKMMSTGAQHELLEIGTNSPEMTPADGLSVGEVGYLITGVKDVRQSKVGDTVTRLSKGATEPLGGYKDPKPMVFSGLYPVDGSDYPELRDALDKLQLNDAALVYEPETSAALGFGFRVGFLGLLHLEVIRERLEREFNLDLIATAPNVIYRVVLEDRTEHVVTNPSEFPVGKIEEVYEPVVRATILTPSEYIGSVMELCQNRRGTLLGMDYLSEERVEIRYTLPLAEVVFDFFDQLKSKTRGYASLDYEPTGEQSSQLVKVDILLHGDKVDAFSAITHKDKAYAYGVRLVAKLKELIPRQAFEVPVQAAIGSRVIARETIRAIRKDVLAKCYGGDISRKRKLLEKQKEGKKRMKMVGNVEVPQEAFIAVLSSDEDGKAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N350</accession>
    <name>A0A0F7N350_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_05915</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015167.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_05915"/>
    <dbReference type="EnsemblBacteria" id="AKH81814">
        <property type="protein sequence ID" value="AKH81814"/>
        <property type="gene ID" value="AA958_05915"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_05915"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1238"/>
    <dbReference type="OrthoDB" id="1515497at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="2">
        <location>
            <begin position="92"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH81814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="292" mass="31798" checksum="EDAF26307290D0D1" modified="2015-07-22" version="1">MIHEYENGTDGAGGAADADVPAEATRRPVPARETRQASRGWWDRNADDYQREHGGFLGGADGARFIWGPEGLDEAEARLLGPADSLTGQAVLEVGAGAAQCSRWLAEQGARPVALDLSHRQLQHARRLALEAPEGAAPFPLLQADATALPFRDGAFDLACSAYGAVPFVAAPVAVMREVRRVLRPGGRWVFSVTHPVRWAFPDEPGPEGLSVAASYFDRTPYVEQDDEGRALYVEHHRTLGDRVRDVVAGGFRLLDLVEPEWPQWHDQEWGGWSPLRGHLIPGTAIFVCEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N361</accession>
    <name>A0A0F7N361_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_13535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016415.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_13535"/>
    <dbReference type="EnsemblBacteria" id="AKH83085">
        <property type="protein sequence ID" value="AKH83085"/>
        <property type="gene ID" value="AA958_13535"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_13535"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2848"/>
    <dbReference type="OrthoDB" id="1984437at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="4"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="138" mass="15637" checksum="8166D9E8E92A57F4" modified="2015-07-22" version="1">MELTSFYPVIGTSRLTESRDFYVRLMGFEVTFEADWYVSLRRPGDPAYELALLDPEHPTVPEGHRASARGLLLNFEVADVDAEWERLVVREGLRPELELRSEDFGQRHFIVADPNGILIDVITPIAPTGEFAGQYAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N377</accession>
    <name>A0A0F7N377_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aminopeptidase N</fullName>
            <ecNumber evidence="4">3.4.11.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Alanine aminopeptidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Lysyl aminopeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">AA958_09725</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal amino acid, Xaa-|-Yaa- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide.</text>
            <dbReference type="EC" id="3.4.11.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.2" evidence="4"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015804.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_09725"/>
    <dbReference type="EnsemblBacteria" id="AKH82461">
        <property type="protein sequence ID" value="AKH82461"/>
        <property type="gene ID" value="AA958_09725"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_09725"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2047"/>
    <dbReference type="OrthoDB" id="771837at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012778">
        <property type="entry name" value="Pept_M1_aminopeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="SSF63737"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02412">
        <property type="entry name" value="pepN_strep_liv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase_M1_N" evidence="15">
        <location>
            <begin position="116"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M1" evidence="13">
        <location>
            <begin position="244"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="ERAP1_C" evidence="14">
        <location>
            <begin position="544"/>
            <end position="856"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AKH82461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="867" mass="96327" checksum="BB7FF92373978A78" modified="2015-07-22" version="1">MPGENLTREEARERARLLEVEAYEVELDLRTAVAPAPGPFRSVTTVRFRCAQPGAATFLDLIAPDVTAVSLNGRDLDPGAVFDGSRITLEDLAAENEVVVDARCAFSRTGEGMHRFVDPEDGEVYLYTQYEPADARRVFATFEQPDLKAPFTFTVTAPRHWTVLSGGALAGPAELHQDESATWRFEPTKPISTYITAVLAGPYAHLEDRYTRTFDDGRELVVPLGALCRRSLARHFDADDVFTVTKQGLDFFHDHFDYPYPWGKYDQAFVPEYNIGAMENPGLVTFREEFVFRGKVTDAAYERRANVVLHEMAHMWFGDLVTMEWWDDLWLKESFADYMGALALAEATRFTGSWITFANRRKAWAYRADQLPTTHPITADIHDLEAAKLNFDGITYAKGAAVLKQLVAYVGRDAFMEGARRYFKRHAFRNTRLADLLAALEETSGRDMSAWAGPWLQTAGVDTLTPQVTYDANERITELAILRESPGTGPGAAAPAPRPHRVAVGLYGQPDASGELVRYARAEVDVTDGHAVVAELAGQPRPELILVNDDDLTFCKARFDEDSLDTVRERLDDVSDPLARALLWATAWDLTRDGLMPARDYLDLVLRFAGRETDIGVLQGLHQQAHYTVDHYAAPGHRAAAEEALAEGALGELRLAPPGSDHQLAWARFFASVAGTEQDLQLLHGLLDGQAKIDGLDVDQELRWEVLLPLVAHGAADAAAVDAELARDDTASGKRHQVRCLAARPDARVKEAAWTAVVDSDELSNAMVEATISGFTRPGQRDLLAPYAPRYFEAIERIWRERTIESAMAVVRGLYPALQAHRGTLDATDTWLRETDGTAPPALRRLVWEARDDLARALRAQERDGQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3H9</accession>
    <name>A0A0F7N3H9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Thiamine-phosphate synthase</fullName>
            <shortName evidence="9">TP synthase</shortName>
            <shortName evidence="9">TPS</shortName>
            <ecNumber evidence="9">2.5.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Thiamine-phosphate pyrophosphorylase</fullName>
            <shortName evidence="9">TMP pyrophosphorylase</shortName>
            <shortName evidence="9">TMP-PPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">thiE</name>
        <name evidence="13" type="ORF">AA958_06625</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 9">Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) = CO2 + diphosphate + thiamine phosphate</text>
            <dbReference type="Rhea" id="RHEA:47848"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:62890"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 9">
            <text>2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) = CO2 + diphosphate + thiamine phosphate</text>
            <dbReference type="Rhea" id="RHEA:47844"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:62899"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 9">
            <text>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 4-methyl-5-(2-phosphooxyethyl)-thiazole + H(+) = diphosphate + thiamine phosphate</text>
            <dbReference type="Rhea" id="RHEA:22328"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:58296"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5 9 11">Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine phosphate from 4-amino-2-methyl-5-diphosphomethylpyrimidine and 4-methyl-5-(2-phosphoethyl)-thiazole: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the thiamine-phosphate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.3" evidence="9"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015291.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_06625"/>
    <dbReference type="EnsemblBacteria" id="AKH81939">
        <property type="protein sequence ID" value="AKH81939"/>
        <property type="gene ID" value="AA958_06625"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_06625"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1382"/>
    <dbReference type="OrthoDB" id="1558094at2"/>
    <dbReference type="UniPathway" id="UPA00060">
        <property type="reaction ID" value="UER00141"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004789">
        <property type="term" value="F:thiamine-phosphate diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00564">
        <property type="entry name" value="TMP_TenI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00097">
        <property type="entry name" value="TMP_synthase"/>
        <property type="match status" value="1"/>
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</entry>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </feature>
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        </location>
        <ligand>
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        <ligand>
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        </ligand>
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    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="AKH81702.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="532" mass="57660" checksum="421FE80C4DA26FC5" modified="2015-07-22" version="1">MITATGLELRAGARVLIESATFRIARGDRIGLVGRNGAGKTTLTKVLAGEGQPAAGTVTRGSTVGYLPQDPRTGDLDVLARDRILAARGLDAVIRKMREDEQRMSGGKGATREKAMRRYERMETEFLTKGGYAAEAEAATIAASLGLPDRVLGQPLHTLSGGQRRRVELARILFSDSEILLLDEPTNHLDADSVVWLRDYLKTYHGGFVVISHDEQLVETVVNKVFYLDANRARIDAYNMGWKLYLAQREADEKRRRRERANAEKKAAALNAQADKMRAKATKATAAQNMARRAERLLSGLDEQRQADKVARLRFPDPAPCGKTPLTAEGLSKSYGSLEVFTDVDLAVDKGSRVVILGLNGAGKTTLLRLLAGVEKPDTGGVTPGHGLKLGYYAQEHETLDPDRSVLENMASAAPDMDAVEMRKVLGSFLFSGDDVEKPARVLSGGEKTRLALATLVVSSANVLLLDEPTNNLDPASREEILGALRTFTGAVVLVTHDEGAVDALEPERIILLPDGVEDLWNADYADLVALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4L1</accession>
    <name>A0A0F7N4L1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_08750</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015651.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_08750"/>
    <dbReference type="EnsemblBacteria" id="AKH82304">
        <property type="protein sequence ID" value="AKH82304"/>
        <property type="gene ID" value="AA958_08750"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_08750"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1846"/>
    <dbReference type="OrthoDB" id="816674at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH82304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="425" mass="47837" checksum="E3763A9B31E391ED" modified="2015-07-22" version="1">MPTDIAEAGRTLADPHAYAEEVRLYSALSLLRRESPVHWVEAPGYNPFWGVTRHADIQDVERRSAVFRNGPRPMLVSRAMDEINRRREQDDAVLRPLVHLDGPEHSTMRSVTADWFRPPRLRRLDRTVRTLARRTVDHMARIGNSCEFVGQVADVYALHVLLSLLGIPESEYETIFRFTPAARRSLPRRARQAAMDDFHTYFSELAARRRGHSADDLASVIANAGVAGRRLTPRQTLAQYVIIIAAGHDTTSATIAGGLHALIGNPSQLRLLRDDPGLLDTAVEEIIRWVTPVKAFMRTAVEDDALRGVHIRRGESLLLSYPSANRDAEVFERPDEFDVRRRPNRHLSFGYGVHHCLGAALARMEIRAFFAELVPRLLSVELAGKPELIRTTFSGGLKYLPIRYSVAPARTPHRNGKGPHACEDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4U6</accession>
    <name>A0A0F7N4U6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Methionine ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_17335</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016984.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_17335"/>
    <dbReference type="EnsemblBacteria" id="AKH83680">
        <property type="protein sequence ID" value="AKH83680"/>
        <property type="gene ID" value="AA958_17335"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_17335"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3645"/>
    <dbReference type="OrthoDB" id="1101128at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="12"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="44"/>
            <end position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH83680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="334" mass="35167" checksum="23A6B8AB1332D8D7" modified="2015-07-22" version="1">MPATTVETSAAARLRDVHIAFGPREVVRGVDLDLVPGRVTALVGESGSGKSLTSLALMGLLPPGAAVSTGTVEIDGRDTAGFTDAQWRELRGAQVAMVFQDPMAALNPSFTIGWQIAETLRRRGTGRRAARERAVELMRTVGIPDAEAKYGAYPHEFSGGMRQRAVIAMALTLDPAVLLADEPTTALDVTVQAQILRLLAARQTDAGMAMLLVSHDLGVVARVAQDVAVMYAGRIVETGALDDVYTAPAHPYTRGLLDAVPDPARPGRLVPIEGQPPAPGRQPAGCAFAPRCPYATEVCRTEDPQLSAVGQGHEAACHHSDKVQAQATDVEAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4Z1</accession>
    <name>A0A0F7N4Z1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">ATP-dependent Clp protease proteolytic subunit</fullName>
            <ecNumber evidence="5">3.4.21.92</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Endopeptidase Clp</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">clpP</name>
        <name evidence="8" type="ORF">AA958_09655</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 7">Belongs to the peptidase S14 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.92" evidence="5"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_09655"/>
    <dbReference type="EnsemblBacteria" id="AKH82449">
        <property type="protein sequence ID" value="AKH82449"/>
        <property type="gene ID" value="AA958_09655"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_09655"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2034"/>
    <dbReference type="OrthoDB" id="1728970at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07017">
        <property type="entry name" value="S14_ClpP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00444">
        <property type="entry name" value="ClpP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001907">
        <property type="entry name" value="ClpP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023562">
        <property type="entry name" value="ClpP/TepA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033135">
        <property type="entry name" value="ClpP_His_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381">
        <property type="entry name" value="PTHR10381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00574">
        <property type="entry name" value="CLP_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00127">
        <property type="entry name" value="CLPPROTEASEP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00382">
        <property type="entry name" value="CLP_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 8" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0720">Serine protease</keyword>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 6">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH82449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="204" mass="21579" checksum="F62A366E07BDE87C" modified="2015-07-22" version="1">MTNPMLSGPGEPSFGGLGDQVYNRLLNERIIFLGQPVDDDIANKITAQLLLLAADPDKDINLYINSPGGSVTAGMAIYDTMQFIKNDIVTIALGLAASMGQFLLSAGTPGKRFALPNAEILIHQPSAGLAGSATDIKIHAEQLIRTKKKMAELTSLHTGQTVEQVTHDSDRDRWFSAEEAKEYGLIDEVMPSASGIPGGGGTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N506</accession>
    <name>A0A0F7N506_9ACTN</name>
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        <submittedName>
            <fullName evidence="2">Endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_09860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015830.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_09860"/>
    <dbReference type="EnsemblBacteria" id="AKH82488">
        <property type="protein sequence ID" value="AKH82488"/>
        <property type="gene ID" value="AA958_09860"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_09860"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2077"/>
    <dbReference type="OrthoDB" id="1843957at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00085">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029471">
        <property type="entry name" value="HNH_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14279">
        <property type="entry name" value="HNH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00507">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNHc" evidence="1">
        <location>
            <begin position="70"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="178" mass="19532" checksum="2E35625EC18599FF" modified="2015-07-22" version="1">MPHVLVLNASYEPLGVVPLRRALVLVLNGKAVSLEESGAFLHSATRVIAAPSVVRLQRFVRVPVRGPVPLTRRALFARDGGRCAYCGGVATSVDHVIPRSRGGQHRWDNVVAACRRCNHVKADRAIHELGWRLRHQPAPPSGLAWRIIGTGHRDPRWLPYLQPYGADEALARIDGISA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N564</accession>
    <name>A0A0F7N564_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_18000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017086.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH83785">
        <property type="protein sequence ID" value="AKH83785"/>
        <property type="gene ID" value="AA958_18000"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_18000"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3786"/>
    <dbReference type="OrthoDB" id="1261526at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH83785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="235" mass="24441" checksum="A7C8BB443DACB30F" modified="2015-07-22" version="1">MTHYSPVTLVTGGGSGIGAAAARQLLARGGRVAVTGRGAERLRRFARDAGDPPELLTLPGDASDHEAVAEAVQATLTAFGRLDAVVANAGFASHDDLATGDPAGWRDMVLTNVLGPALLIRSSLEALRETRGRIVIVGSVAGFVHTPGNIYGITKWAMTGLAENTRRMVTGDGIGVTLVAPGRTDTLFWDGMGGAPEGMEMMTSDQVAESIVWALNQPEGVDVNTVVMRPIGQPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5H5</accession>
    <name>A0A0F7N5H5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LacI family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_07290</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015412.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_07290"/>
    <dbReference type="EnsemblBacteria" id="AKH82062">
        <property type="protein sequence ID" value="AKH82062"/>
        <property type="gene ID" value="AA958_07290"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_07290"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1527"/>
    <dbReference type="OrthoDB" id="664909at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="4"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH82062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="342" mass="36435" checksum="75BAD2EFC3D061BE" modified="2015-07-22" version="1">MPGARLKDVAERAGVSIKTVSNVVRGAARVAEPTRERVLRAIDELGYRPHASARHLRTGRSGVIALAVPELVAPYFAELATCVIAAAKESGQTVLIEVTDGDPAEELRLACGLGDPLIDGVLLSPLGLDQTALAARERRVPLVLLGERDYEVPADHVLIDNVAAARDATRHLVGRGRRRIGVIGWQHDDRTTATALQRMQGHREALAEAGLAYDQALAPAVGSYTRAGGAAAMRELLALREPPDAVFCFTDMMASGAMRVAHDEGLAIPADLAVVGFDDIQEARYMVPSLTSVAPDKQELARLAVKALLARIEGPAEAPPTTLLAPYELALRESSALPQDRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5I5</accession>
    <name>A0A0F7N5I5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_18295</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017134.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH83835">
        <property type="protein sequence ID" value="AKH83835"/>
        <property type="gene ID" value="AA958_18295"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_18295"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3845"/>
    <dbReference type="OrthoDB" id="1437290at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="6"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH83835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="186" mass="20953" checksum="F5BC7D2ABBA6F3F6" modified="2015-07-22" version="1">MGTTRSDTRQRIQDVALELFADKGYDKTSLREIAERLDVTKAALYYHFKTKEDILVSLVEDHFGRVDELIAWGRSQPATLETRLELLARYSALLAGGDTLFRFMQENQASIRELSLGETFKARMADIIGMLRDKDADLRDQARSIAAIFTMHAGMFALDDAKGDPEEKRLACLEVAQELVTSAYKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-10-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5K5</accession>
    <name>A0A0F7N5K5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PadR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_18420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017153.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH83855">
        <property type="protein sequence ID" value="AKH83855"/>
        <property type="gene ID" value="AA958_18420"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_18420"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3867"/>
    <dbReference type="OrthoDB" id="1706427at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
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        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
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        <property type="entry name" value="PadR"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="1">
        <location>
            <begin position="6"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="170" mass="19092" checksum="29DD150F45318C89" modified="2015-07-22" version="1">MLELAILGFLAEEPLHGYQLRRRIAHLSGHTRPVSDGSLYPAINRLVRAGLLDRRTEPGASAAQRQTLSLTDAGREELLRRLREADGLDVSDSSRFFTVLAFLSRLPDTADQHAVLRRRLDFLEQPASFFHDGDRPLSAGDTDDPYRRGMLTVARATSRAERAWLRETLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5L8</accession>
    <name>A0A0F7N5L8_9ACTN</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_07585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_07585"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1591"/>
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    </dbReference>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="363" mass="38650" checksum="59A1D251B8909003" modified="2015-07-22" version="1">MTEQRLTLAAGTRLLHIGPYKTGTTALQGAFHHSRERLAAGGAVYAGKGRQARVAAAAVTGARLRKGSVTPTAADWDGLCAEVAAAGERRVMISSEAFCNAEADAARRAVEGLGGERVHVAVTLRPLVKIVPSQWQQDVKDGLCTPYEEWLETVFRGPRQDPVAATFWLRHRHDELVARWVRAVGPDRLTVVVVDETDRDMQLRVFEELLGVAAGTLVPEDGVINRSLTLGEVELLRQLNIEAEARGWSGGRYHKVIRNGVMRHLDQTYSPPPDAPRITTPRWATEAAAAVANEIVAGITAAGVRVAGNLHSLAPPPAPPTAPSAAPAAPPTATLPAEAAAAALWGGLQAAARKPKTPPAHHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5N8</accession>
    <name>A0A0F7N5N8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">N-acetylmuramoyl-L-alanine amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_07735</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015492.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_07735"/>
    <dbReference type="EnsemblBacteria" id="AKH82142">
        <property type="protein sequence ID" value="AKH82142"/>
        <property type="gene ID" value="AA958_07735"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_07735"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1626"/>
    <dbReference type="OrthoDB" id="1184688at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02696">
        <property type="entry name" value="MurNAc-LAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002508">
        <property type="entry name" value="MurNAc-LAA_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01520">
        <property type="entry name" value="Amidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00646">
        <property type="entry name" value="Ami_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519228" evidence="2">
        <location>
            <begin position="35"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="MurNAc-LAA" evidence="3">
        <location>
            <begin position="172"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH82142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="305" mass="31872" checksum="0E0C88011B8E7FD0" modified="2015-07-22" version="1">MSSQNRRPLRAYLLLAPVAPLAFAGVLVWQSADGDGSGGNGREPGGAPPASSSPTRPTAEDPEDSSDSKNAKDAKDPEVGVMPLAGKVIVLDPGHNPNNRDHAAEINRQVDIGTVRKECDTTGTATNGGYAEADFTLDVARRARTLLRAQGAEVRLTQDGKREFGPCIDERAEAGNKAGADAVVSIHADGGGPGSRGFHVILPGEVNEGKADTTAIVKPSRKLGKELKSHFAEETGSKPSNYVGNDTGFTVRTDLGGLNLSTVPKVFIECGNMRDAKDADRLTDAAWRQRAAHGITNGIGAFLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5S1</accession>
    <name>A0A0F7N5S1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">LysM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_11735</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transglycosylase family. Rpf subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_11735"/>
    <dbReference type="EnsemblBacteria" id="AKH82793">
        <property type="protein sequence ID" value="AKH82793"/>
        <property type="gene ID" value="AA958_11735"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_11735"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2467"/>
    <dbReference type="OrthoDB" id="2063919at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13925">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010618">
        <property type="entry name" value="RPF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06737">
        <property type="entry name" value="Transglycosylas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="SSF54106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519812" description="LysM domain-containing protein" evidence="3">
        <location>
            <begin position="25"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="4">
        <location>
            <begin position="184"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="100"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="118"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH82793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="233" mass="24510" checksum="BCA72B5D6CAD20B1" modified="2015-07-22" version="1">MVVLMGATGTAIGLPVLGAQHASAAPIDTWERVAACESSGNWSTNTGNGYFGGVQFSQSSWEAAGGRSFAPRADLASKQQQIAVAERLLSMQGPGAWPNCGPRAGLAAGGPAAGQIVPPAPQEAPQPPPQEQPQPQPPQEPQEAQTLPAPAAQEQAPQEAPEGTEASGAAEQTQPESRTVFRGFYYEVREGDTLDDIAQRHGAESWQQLYEDNKPVVGENPDLIRPGQKLKVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5S6</accession>
    <name>A0A0F7N5S6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Long-chain fatty acid--CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_15440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016683.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_15440"/>
    <dbReference type="EnsemblBacteria" id="AKH83371">
        <property type="protein sequence ID" value="AKH83371"/>
        <property type="gene ID" value="AA958_15440"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_15440"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3250"/>
    <dbReference type="OrthoDB" id="377638at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="35"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="455"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH83371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="550" mass="60102" checksum="E5B9FAB90B7F7C53" modified="2015-07-22" version="1">MLSTMQDVPLTISRIVTHGSTIHGAARVLTWTGSGEPPRSRTYAEVGARAAQLAYALRDELGVRQQEPVGTLMWNNAEHLEAYLALPAMGSVLHTLNLRLDPRQLVWIINHARDRVLLANGTLLPLLAPLLPHLPAVEHVVVAGAGDRTALDGTHVTVHDYEELLAGRPESYDWAVLDEREAAALCYTSGTTGDPKGTLYSHRSVYLHSLGVLAAESFGITVHDLALPIVPMFHVNAWGLPHAAFMAGTSLLMPDRFLQPGPIAEMMETCRPTISGAVPTIWQALLNELDARPRDVSSLRTAIVGGTACPPQLMKGFEERHGIRVVQAWGMTETSPLGCIAHPPAGLEPAEEYPYRLKQGRFPATVEARLRGPDGSLLPKDGESAGELEVRGPWIAGAYYGGADGEPFRPDDKFSEDGWLRTGDVGTITADGYLTLTDRAKDVIKSGGEWISSMELENHLMAHPDVAEAAVIAVPDETWEERPLAAVVLREGAEVTDEELRTYLGERIAKWQLPERWARIGEVPKTSVGKFDKKVLRRRYADGELTVTRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N692</accession>
    <name>A0A0F7N692_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_16875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016910.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH83606">
        <property type="protein sequence ID" value="AKH83606"/>
        <property type="gene ID" value="AA958_16875"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_16875"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3550"/>
    <dbReference type="OrthoDB" id="2097816at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="68" mass="7480" checksum="F740A4F3F9D7F8EE" modified="2015-07-22" version="1">MAESRDNDRLAARLVAVGALGFVLVVPPLLAQFDRVDRVFGVPVLWAYLYLVWAIVIGLVALIGTRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6D9</accession>
    <name>A0A0F7N6D9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acetyl-CoA acetyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_12550</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.9" evidence="5"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016259.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_12550"/>
    <dbReference type="EnsemblBacteria" id="AKH82924">
        <property type="protein sequence ID" value="AKH82924"/>
        <property type="gene ID" value="AA958_12550"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_12550"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2637"/>
    <dbReference type="OrthoDB" id="330994at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003985">
        <property type="term" value="F:acetyl-CoA C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="3">
        <location>
            <begin position="18"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="4">
        <location>
            <begin position="298"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="1">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="394"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH82924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="446" mass="46188" checksum="C56E9C478B9E83D6" modified="2015-07-22" version="1">MAAAARTGGRTGGGVRRVAIVGGNRIPFARADGAYATASNQEMLSAALDGLVGRYGLRGALLDEFVAGAVLKHSRDFNLAREVVLGSGLDHRTPAYDVQQACGTGLQAVLLVANKIALGQIDAGVAGGVDTASDAPLGLNDGLRRVLLHARRQRSTGRRIAALAGLRPRHVVPDVPRNAEPRTGLSMGEHAAFTAREWRVPRAAQDELAAASHRWLAAAYDAGFFADLLTPFRGLDRDQNLRPDSTPDKLARLKPVFGAADPGATMTAGNSTPLTDGAATVLLASEEWAAARGLPVLAYLTHARTGAVDFAGGPDGLLMAPAYVVPRLLADAGLALADLDLYEIHEAFASQVLATLAAWEDAAFCKERLGLDAPLGTVDRERLNVAGSSLAAGHPFAATGGRIVATLAKLLHERAAERASGNTAPVRGLISVCAAGGQGVTALLEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6L9</accession>
    <name>A0A0F7N6L9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpsJ</name>
        <name evidence="6" type="ORF">AA958_21170</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in the binding of tRNA to the ribosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS10 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003948644.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A0F7N6L9"/>
    <dbReference type="STRING" id="444103.AA958_21170"/>
    <dbReference type="EnsemblBacteria" id="AKH84285">
        <property type="protein sequence ID" value="AKH84285"/>
        <property type="gene ID" value="AA958_21170"/>
    </dbReference>
    <dbReference type="GeneID" id="63982123"/>
    <dbReference type="GeneID" id="67399231"/>
    <dbReference type="KEGG" id="strc:AA958_21170"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4459"/>
    <dbReference type="OrthoDB" id="2012682at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00508">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001848">
        <property type="entry name" value="Ribosomal_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018268">
        <property type="entry name" value="Ribosomal_S10_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027486">
        <property type="entry name" value="Ribosomal_S10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036838">
        <property type="entry name" value="Ribosomal_S10_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11700">
        <property type="entry name" value="PTHR11700"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00338">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00971">
        <property type="entry name" value="RIBOSOMALS10"/>
    </dbReference>
    <dbReference type="SMART" id="SM01403">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54999">
        <property type="entry name" value="SSF54999"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01049">
        <property type="entry name" value="rpsJ_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00361">
        <property type="entry name" value="RIBOSOMAL_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_S10" evidence="5">
        <location>
            <begin position="7"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH84285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="102" mass="11521" checksum="87AE8768EB157E09" modified="2015-07-22" version="1">MAGQKIRIRLKAYDHEVIDSSAKKIVETVTRTGASVAGPVPLPTEKNVYCVIKSPHKYKDSREHFEMRTHKRLIDILDPTPKTVDSLMRLDLPAGVDIEIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6Z6</accession>
    <name>A0A0F7N6Z6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AA958_13940</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016482.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_13940"/>
    <dbReference type="EnsemblBacteria" id="AKH83154">
        <property type="protein sequence ID" value="AKH83154"/>
        <property type="gene ID" value="AA958_13940"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_13940"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2934"/>
    <dbReference type="OrthoDB" id="433393at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041504">
        <property type="entry name" value="AidB_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18158">
        <property type="entry name" value="AidB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AidB_N" evidence="8">
        <location>
            <begin position="9"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="177"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="283"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH83154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="553" mass="58765" checksum="AEE0C0DD802F4BB9" modified="2015-07-22" version="1">MPTTHEVTNQPPPLTSYDVSAYPALLESLRAHGASWAEDEVRELGLLAGGPQAQEWARSVEEHPPVLRTHDRYGHRIDEVEFSPHWHDLMRTAVGHGLHAAPWRARTPGAHVARAAKLFVWGQTDAGHLCPVSMTYAAVPALRTSPDLAAAYEPLLTSAAYDFGLRPPTTKSGLIAGMSMTEKQGGSDVRANTTRAVPAGDGDGLYALTGHKWFTSAPMSDVFLTLAQAPGGLSCFLVPRVLPDGTRNAIRLMRLKDKLGNRSNASAEIEYEGAVGHLVGEEGEGVKTIIKMVNMTRLDCALATAGGMRLGVVQALHHAEHRRAFGARLADQPLMANVLADLAVEAEAATVAGMRLAGAVDRGETGRADEQEALFRRIGLAVTKYWVCKRGPAHAAEALECLGGNGYVEESGMPRLYREAPLPSIWEGSGNVAALDALRAMARRPETVTAFFAEVGAAAGADARLDAAIGRLRKDLADVTAVEYRARRVVESMALVLQGALLHRHGDAAVADAFCASRLAGDGGLAFGTLPPGADTDTILKRARPTGGAYGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7D1</accession>
    <name>A0A0F7N7D1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_14960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016618.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_14960"/>
    <dbReference type="EnsemblBacteria" id="AKH83303">
        <property type="protein sequence ID" value="AKH83303"/>
        <property type="gene ID" value="AA958_14960"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_14960"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3153"/>
    <dbReference type="OrthoDB" id="1681721at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045383">
        <property type="entry name" value="DUF6528"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20138">
        <property type="entry name" value="DUF6528"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519204" evidence="1">
        <location>
            <begin position="31"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="317" mass="34213" checksum="FE33C41051C72406" modified="2015-07-22" version="1">MKRRSLLTGALAGAVAAPAAVTLGASKANAAVADYPIALTDQATNSFQVFDRTGDWSAASDWSFTPGTTNGWDDPFEIRFRATTRYGTIALMTAGQPGNGRAGIVAVTGNGNRLDRGDLIWEASVASYPHCIERIPNVAAVVVAGTRDRIHVYGGANSDHSTLREVQTITDMPKPHAVLWDDVNDLLWVTGGTVIRTYRVTGANSTARLVKSGTDITFAGNGHDIQPDYTDPGKLWVTDSGRVYSLDKATRKVTIISEENYVKSYVRYTDGEAMWTLDPTPADPPWGGPTVYFSGGQSKTRPGAQIYKARIVTTRFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7F4</accession>
    <name>A0A0F7N7F4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Potassium-transporting ATPase ATP-binding subunit</fullName>
            <ecNumber evidence="13">7.2.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">ATP phosphohydrolase [potassium-transporting] B chain</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Potassium-binding and translocating subunit B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Potassium-translocating ATPase B chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">kdpB</name>
        <name evidence="15" type="ORF">AA958_15125</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system and for the release of the potassium ions to the cytoplasm.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O + K(+)(out) = ADP + H(+) + K(+)(in) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:16777"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="13">The system is composed of three essential subunits: KdpA, KdpB and KdpC.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cell membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IA subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.6" evidence="13"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016642.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_15125"/>
    <dbReference type="EnsemblBacteria" id="AKH83328">
        <property type="protein sequence ID" value="AKH83328"/>
        <property type="gene ID" value="AA958_15125"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_15125"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3187"/>
    <dbReference type="OrthoDB" id="237367at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008556">
        <property type="term" value="F:P-type potassium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02078">
        <property type="entry name" value="P-type_ATPase_K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00285">
        <property type="entry name" value="KdpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006391">
        <property type="entry name" value="P-type_ATPase_bsu_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43743">
        <property type="entry name" value="PTHR43743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01497">
        <property type="entry name" value="kdpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 13" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 13" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8 13" id="KW-0630">Potassium</keyword>
    <keyword evidence="4 13" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-1278">Translocase</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="265"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="603"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="636"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="675"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="13">
        <location>
            <position position="320"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="357"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="361"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="391"/>
            <end position="398"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="409"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="537"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="541"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AKH83328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="702" mass="73596" checksum="3AC339F7CB4B29A3" modified="2015-07-22" version="1">MSIQTRTPAPAPRTDADPVRHASGPRVGGGLFDPRQLLRSVPDALRKLDPRALVKSPVMFVVEIGSVLTTVLAVTDPGDWFGWVIAAWLWLTVLFANLAEAVAEGRGKAQADTLRRAKTDTVARRRTAAGEERVPGTDLRVGDLVVCEAGDVIPGDGDVAEGVASVDESAITGESAPVIRESGGDRSAVTGGTKVLSDRIVVRITAKPGETFIDRMIALVEGAARQKTPNEIALNILLSSLTIVFLLAVVTLQPFAVYAGAEQSLVVLAALLVCLIPTTIGALLSAIGIAGMDRLVQRNVLAMSGRAVEAAGDVSTLLLDKTGTITLGNRQAHEFLPVPGAEEAELADAAQLSSLADETPEGRSIVVLATSRYGLREREPGALAHADWVPFTAQTRMSGVDVDGRRIRKGAAGAVAAWVRERGGELPDTVRDMADTVADSGGTPLLVAVADERGGARVLGVVHLKDVVKEGMRERFAELRRMGIRTVMITGDNAGTAKAIAAEAGVDDFLAEATPEDKMALIKREQAGGKLVAMTGDGTNDAPALAQADVGVAMNTGTSAAKEAGNMVDLDSNPTKLIEIVEIGKQLLITRGALTTFSIANDVAKYFAIIPAMFAAAYPSLDKLNIMQLSSPESAILSAVVFNALIIVALVPLALRGVRYRPMSADRMLRRNIGVYGLGGLVAPFIGIKLIDLVVSLIPGIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7H0</accession>
    <name>A0A0F7N7H0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Exodeoxyribonuclease 7 large subunit</fullName>
            <ecNumber evidence="5">3.1.11.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Exodeoxyribonuclease VII large subunit</fullName>
            <shortName evidence="5">Exonuclease VII large subunit</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">xseA</name>
        <name evidence="9" type="ORF">AA958_22695</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield nucleoside 5'-phosphates.</text>
            <dbReference type="EC" id="3.1.11.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterooligomer composed of large and small subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the XseA family.</text>
    </comment>
    <dbReference type="EC" id="3.1.11.6" evidence="5"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017802.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_22695"/>
    <dbReference type="EnsemblBacteria" id="AKH84545">
        <property type="protein sequence ID" value="AKH84545"/>
        <property type="gene ID" value="AA958_22695"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_22695"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4774"/>
    <dbReference type="OrthoDB" id="1371775at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009318">
        <property type="term" value="C:exodeoxyribonuclease VII complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008855">
        <property type="term" value="F:exodeoxyribonuclease VII activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04489">
        <property type="entry name" value="ExoVII_LU_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00378">
        <property type="entry name" value="Exonuc_7_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003753">
        <property type="entry name" value="Exonuc_VII_L"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020579">
        <property type="entry name" value="Exonuc_VII_lsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025824">
        <property type="entry name" value="OB-fold_nuc-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30008">
        <property type="entry name" value="PTHR30008"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02601">
        <property type="entry name" value="Exonuc_VII_L"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13742">
        <property type="entry name" value="tRNA_anti_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00237">
        <property type="entry name" value="xseA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5 6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA_anti_2" evidence="8">
        <location>
            <begin position="15"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="Exonuc_VII_L" evidence="7">
        <location>
            <begin position="128"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="Exonuc_VII_L" evidence="7">
        <location>
            <begin position="327"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH84545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="403" mass="43786" checksum="ABDAE3E5E822EC4C" modified="2015-07-22" version="1">MAVNTAETPMPVGLVSRKIGGWIDRLGSLWVEGQITQLSRRPGAGVVFMTLRDPAQEVSLTVTCFRDVFDKVADVIQEGARVVVFAKPLWYAPSGQLSLRAAEIRPVGVGELLVRLERLKKALAAEGLFAPERKKPLPFLPRRIGLVTGRASAAERDVLETARHRWPAVRFEVRPVAVQGVHAVPQIVKAVQELDGLPEVDVIIVARGGGSVEDLLPFSDEQLVRAVAACRTPVVSAIGHEPDNPLLDYVADLRSRTPTHAAKDAVPDVGEERVRIEQLRLRALRVLTGVLDREERGLAAWLSRPAMAEPYAIVDERAEVVDAVLARGRRTLAHLLDRADSELEHTRARVVALSPASTLKRGYAVLQRQDGAAVRAADEVSAGQELRARVADGEFGVTVGPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7Q6</accession>
    <name>A0A0F7N7Q6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Growth inhibitor PemK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_19855</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017351.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH84061">
        <property type="protein sequence ID" value="AKH84061"/>
        <property type="gene ID" value="AA958_19855"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_19855"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4184"/>
    <dbReference type="OrthoDB" id="1754531at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003477">
        <property type="entry name" value="PemK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011067">
        <property type="entry name" value="Plasmid_toxin/cell-grow_inhib"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02452">
        <property type="entry name" value="PemK_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH84061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="104" mass="11384" checksum="BF6074B34B35B5B6" modified="2015-07-22" version="1">MRGDIFRLRAPRQRVGHAQRGMRYGVVLQTEALATSTLVVAPTSTSARPGLIHPRVEMAGTDTVVLVEQMAAVDPERLGDFAGRVEPAEWEDIEHAVRLVLGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7R9</accession>
    <name>A0A0F7N7R9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sec-independent protein translocase protein TatB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">tatB</name>
        <name evidence="8" type="ORF">AA958_23300</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TatB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017901.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_23300"/>
    <dbReference type="EnsemblBacteria" id="AKH84645">
        <property type="protein sequence ID" value="AKH84645"/>
        <property type="gene ID" value="AA958_23300"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_23300"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4912"/>
    <dbReference type="OrthoDB" id="2073616at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033281">
        <property type="term" value="C:TAT protein transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043953">
        <property type="term" value="P:protein transport by the Tat complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00237">
        <property type="entry name" value="TatB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018448">
        <property type="entry name" value="TatB"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 6" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="106"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="106"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH84645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="158" mass="17244" checksum="EAD2CB5C712217CD" modified="2015-07-22" version="1">MFFDIGPLELIALIILATIVFGPDKLPKVIQDTMRFIRKVREFSDSAKEDIRKELGPEFKDFEFEDLNPKNFAKKHLLDNDDLGLKEIRNGFDLKKEVAEVGEAARTVGDIEDDGAAGGKRLSLTKESGGGTDAKSDAAGEAKGTATAERPPYDADAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7U2</accession>
    <name>A0A0F7N7U2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_20050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017386.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_20050"/>
    <dbReference type="EnsemblBacteria" id="AKH84096">
        <property type="protein sequence ID" value="AKH84096"/>
        <property type="gene ID" value="AA958_20050"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_20050"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4224"/>
    <dbReference type="OrthoDB" id="1483891at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH84096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="348" mass="36931" checksum="1A5E71E31925819C" modified="2015-07-22" version="1">MTGELGSLGALAAANGGVLVCAEALAAGWSSGVLVRRLRKEGWRKVRAGVWVEPGRVPDLRLRLRVAQAGRPELVVSHSAAAHLLGVEVLAVRPEFTHVRSRGRAPEGCLLHRTALSDDEIVSVAGLRVTDASRTLVDLLRTAERDAALVAVESALTRRPLAPGGGWPRRWREQVTDLHAVSEALAGIGQRRGVVQARQRLALVDPRSGSPAETVARLRMYDAGLRPLSQVPFTAPNGRRIRVDFFFPVAGLVVEIEGYGFHGGRAAHRADVERFNDLGRCPEVRRMLRFTAADAFERPQRMLHAIRAALGEIAAGGSHPADAAARAAASAGASSAAAEVTASATAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7W1</accession>
    <name>A0A0F7N7W1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidoglycan glycosyltransferase</fullName>
            <ecNumber evidence="1">2.4.1.129</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AA958_16105</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23708"/>
            <dbReference type="Rhea" id="RHEA-COMP:9602"/>
            <dbReference type="Rhea" id="RHEA-COMP:9603"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:78435"/>
            <dbReference type="EC" id="2.4.1.129"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.4.1.129" evidence="1"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016788.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_16105"/>
    <dbReference type="EnsemblBacteria" id="AKH83479">
        <property type="protein sequence ID" value="AKH83479"/>
        <property type="gene ID" value="AA958_16105"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_16105"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3394"/>
    <dbReference type="OrthoDB" id="652304at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008955">
        <property type="term" value="F:peptidoglycan glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3810.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001264">
        <property type="entry name" value="Glyco_trans_51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036950">
        <property type="entry name" value="PBP_transglycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00912">
        <property type="entry name" value="Transgly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Transgly" evidence="11">
        <location>
            <begin position="166"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="10">
        <location>
            <begin position="460"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="783"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="817"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="850"/>
            <end position="891"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AKH83479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="904" mass="96139" checksum="0F04D3C0835F149E" modified="2015-07-22" version="1">MSEHRRKPPNSGRGGGRHGAHSGRRGTPGADGGVSAGRRAAGGGGGRRRAPDGNTAYDAGAGAGAGAAAGAAAGHGRSHSAAGGYDGPRRRRRPEPPPRKRFIDYPRSNHTGLRRWLPSWKQVMGMCVLGFGALVGLFFLGYMLVSVPDVAAAARAQNNVYYWSDGTQMATYGGERNRQIVDLEDIPKEMQNAVIAAENATFYSDPGIDPKGITRAVINMAGGGSTQSGSTITQQYVKNAMLDDQSQTLSRKVKELFVSIKVGAKVDKNEILAGYLNTAYYGRGAYGIQAAAQAYFRVDAENLKPDQSAFLAAVLKGPDLYDPQGGSVPGASPEDNRKRAEERWEWILDRQTEVELDGQKMMSPAERAKYDKFPEIEKYNPSAGLTGQKGYLIETANRYVLKNSNIGKEELERGGYRIYTTFDKKKVAQMEKAVDDARKEYLDPKTREKDKYVQFGGASVDPTTGKIVALYGGEGFDNDHFTNNADTLGVPVGSTWKPFVLASAFENGTYRSEGEPISPESKYNGNNKIIIRDQNGDPMPGPDGEDFRQVNESDYPYGYVTLEKAMGLSINSPFVQLGVDVGLSNVQKTALSAGILEESMPKREDLDASFSLGTSTPSAIRMASAYATFAASGEHIEPYSVTKVIKKGDELPGYDDHPTERGMDANVADNVTKILNEQVVNGEYGELGEGTGAAAKDLGRPAAGKTGTTDENKSAWWVGYTPQLSTAVTLFRTDPRSEKQELLSMNGTGGFDSIHGGQIPTEIWTNYMKEALKGTDVIEFPVPDPLGDIVDGGGVPSPTQSSIDPEPTESEPSEEPDDPTSSPPPSTSPPPSQTCEPWDLECQSGGATNGGDPGGETTGETTTGETTGETTTGETTGETTTGGQPNGGNGNGGSGGDDGGGLIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N851</accession>
    <name>A0A0F7N851_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_20685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_20685"/>
    <dbReference type="EnsemblBacteria" id="AKH84206">
        <property type="protein sequence ID" value="AKH84206"/>
        <property type="gene ID" value="AA958_20685"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_20685"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4363"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="534" mass="54249" checksum="CFFE870410C031EE" modified="2015-07-22" version="1">MGRERADAAKLREQVGTAGVMGALAGAALAGGRGARVAVAGAAAGAVGLGVAEAVARVRQRPGEIPALWQRIAASGALAATAGWAGARLTGAGPVTVGTVAGAAAGALGIRPHKVALGPVVGAAVGGAYALRGGAAGARSRITGSGNRAVAPASSPRARGGGAGHAALRTLGSATGGGGGAATPRRRRAGARVTLGAAGSVGRGPRSPGPARTGPARTAAARPRPGAVAARGAAVAAGAVVAFRVVSALVFREAQVSLVAEEAATEDLPFVVPLEARSAYVGTSYVRELAGVLGGTYTADAPDVGIVESLDALAGPGFDPAEVDPRVREFYEHTARFTLDIEPRWRLWVRPGYLLYRTLVAQPLGQANVPMNQREVLRGMRSRIDTITPAPDKAAAGQTAIRGWIRSFADTDDPIYVGIYTTYRHGDRGYVSVGFPLPHASFTATLLPRSRPGGGLTLTSHAADEAGAGGTGHPGHYLTYIAPGTRELTTLGVHGFAERLDVHVGGDGRLRAEHAFSVFGIPFLVLHYRMERKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-12-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8E5</accession>
    <name>A0A0F7N8E5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_17705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
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    <dbReference type="Proteomes" id="UP000034283">
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="74" mass="6905" checksum="357301FD43C629A6" modified="2015-07-22" version="1">MGFIVFGVAAIGLVVALSFTLSRHPADRGVPSGTRRRGFAGRSGGGADTGYWGGDSGGGDCGGGGGGDGGGGGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8I4</accession>
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        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="entry name" value="Alpha/beta_knot_MTases"/>
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    </dbReference>
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        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="76"/>
            <end position="153"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH83067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="318" mass="33229" checksum="4DB4C26614D54D78" modified="2015-07-22" version="1">MAGNSQRRGRRTASKKGATKGSGGKGRRSLQGKGPTPPAEQRPGHAKQRAANARSKRAVAARPAARRRGGKGSSELVVGRNSVYEALRDGVPATTLYVQQYVDSDDRVRAALQLAGDRGDVHLMEAPRPELDRMTDGLNHQGLVLQVPPYEYAHPEDLLDAAAEDAEDLLTVALDGVTDPRNLGAVVRSVSAFGGHGVVIPERRAAGMTAGAWKSSAGTAARTPVARATNLTRALEAYQKAGVMVVGLAADGEVELPDLDLLDGPVCIVVGSEGKGLSRLVGETCDVRVRIPMPGGAESLNAGVAAGVVLYEAARRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8K6</accession>
    <name>A0A0F7N8K6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transporter</fullName>
        </submittedName>
    </protein>
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        <name evidence="6" type="ORF">AA958_21555</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
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        </lineage>
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    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP011492">
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    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_21555"/>
    <dbReference type="EnsemblBacteria" id="AKH84356">
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        <property type="gene ID" value="AA958_21555"/>
    </dbReference>
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    <dbReference type="PATRIC" id="fig|444103.5.peg.4539"/>
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    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="91"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="122"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="269"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="375"/>
            <end position="408"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH84356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="416" mass="41532" checksum="488A5D00D3ED495F" modified="2015-07-22" version="1">MSDQATPLARRLGVGDAVLVGLGAMLGAGIFAALAPAARAAGSGLLIGLGAAAVVAYCNATSSARLAARYPASGGTYVYGRERLGPFWGYLAGWAFVVGKTASCAAMALTVGAYAWPEQKHAVAVAAVVALTAVNYRGVQKSALLTRAIVAAVLAVLAAVVVAAFTSGAAEADRLRPGGDTSLWGVLEAAGLLFFAFAGYARIATLGEEVRDPERTIPRAVPVALGITLVAYAAVAVAVLAVLGAGGLAHATAPLSDAASAAGAGWLEPAVRVGAAVAALGSLLALILGISRTTLAMARDRHLPHGLAAVHERFRVPHRAELAVGAAVSVAAATVDVRGAIGFSSFGVLLYYAVANASAWTLHPEEGRPPRVVPAVGLAGCVVLAFSLPPASVAAGAGVLAAGAVAYAVRGRWAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9B0</accession>
    <name>A0A0F7N9B0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phenylacetaldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_26105</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
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        <property type="protein sequence ID" value="AKH85120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_26105"/>
    <dbReference type="EnsemblBacteria" id="AKH85120">
        <property type="protein sequence ID" value="AKH85120"/>
        <property type="gene ID" value="AA958_26105"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_26105"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5496"/>
    <dbReference type="OrthoDB" id="744602at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07092">
        <property type="entry name" value="ALDH_ABALDH-YdcW"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015657">
        <property type="entry name" value="Aminobutyraldehyde_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="5">
        <location>
            <begin position="19"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH85120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="476" mass="50979" checksum="3C6E2F4E75692F57" modified="2015-07-22" version="1">MTSEPRRLRNYINGEFRDAADGRTMDVVDPATEEVYATAPLSGAADVDAAVQAAAAAFPGWRDATPGARQLALLKIADALEARADELLETECKDTGKPLELTREEELPMMLDQIRFFAGAARMLEGKSAGEYMDGLTSYVRREPIGVCAQVTPWNYPVMMAIWKFAPALAAGNTVVLKPSDTTPAATVLLAEIMGGILPKGVFNVVCGDRDTGRLMVEHPVPAMASITGSVRAGKEVAGSAAKDLKRVHLELGGKAPVIVFDDADLPKAVEDIAVAGYFNAGQDCTAATRVLVHESVHDEFVSALAKAAAETKTGPGEADALYGPLNNAAQLERVAGFVDRLPAHARVEAGGRRIGDKGYYYAATVVSGLRQDDEIIQNEVFGPVITVQSFTDEDQALAFANGVQYALASSVWTRDHGRAMRLSKALDFGCVWINTHIPLVAEMPHGGFKKSGYGKDLSSYGFDDYTRVKHVMTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9J5</accession>
    <name>A0A0F7N9J5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_15445</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="AKH83372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH83372">
        <property type="protein sequence ID" value="AKH83372"/>
        <property type="gene ID" value="AA958_15445"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_15445"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3251"/>
    <dbReference type="OrthoDB" id="1914729at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014325">
        <property type="entry name" value="RNA_pol_sigma-E_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02983">
        <property type="entry name" value="SigE-fam_strep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="5">
        <location>
            <begin position="31"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="6">
        <location>
            <begin position="120"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH83372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="186" mass="20410" checksum="F43261F45BF203EC" modified="2015-07-22" version="1">MSTASTTDAPAAADTARPPLPTFAAYVHLRGPVLLRTARSLTTSPWDAEDLLQTALAQTYLAWDRIEDPRALDGYVRRALLNTRTSQWRKRRVDEYAAGDDLPEPAPVPGPDPAEHQAMRDAMWRAVLRLPERQRAMVVLRYYEDLSEAQTAAVLGVSVGTVKSAVSRALAKLREDTGLGEMAQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9Z2</accession>
    <name>A0A0F7N9Z2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">2Fe-2S ferredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_27425</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018579.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_27425"/>
    <dbReference type="EnsemblBacteria" id="AKH85345">
        <property type="protein sequence ID" value="AKH85345"/>
        <property type="gene ID" value="AA958_27425"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_27425"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5779"/>
    <dbReference type="OrthoDB" id="1843415at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002888">
        <property type="entry name" value="2Fe-2S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036884">
        <property type="entry name" value="2Fe-2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01799">
        <property type="entry name" value="Fer2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47741">
        <property type="entry name" value="SSF47741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="2">
        <location>
            <begin position="55"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH85345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="208" mass="21887" checksum="4CBBF6AE7852CC4A" modified="2015-07-22" version="1">MSEHEHTTTAGHSRRGVLKAGGIAATELVATGGVTAPAIAAAGEAGAHAPPDPTAEITLRVNGEARRVTVEPRVTLLDALRERLGLTGTKKGCDRGECGACTVLVEGRRVSSCLTLAVMEDSREIMTIEGLADGDELHPVQAAFIRRDAFQCGFCTPGQILSAVACIDEGHARSDDEIREHMSGNLCRCGCYPNIVDAVRDAARRAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9Z7</accession>
    <name>A0A0F7N9Z7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_24510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018098.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_24510"/>
    <dbReference type="EnsemblBacteria" id="AKH84846">
        <property type="protein sequence ID" value="AKH84846"/>
        <property type="gene ID" value="AA958_24510"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_24510"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5164"/>
    <dbReference type="OrthoDB" id="1941441at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005530">
        <property type="entry name" value="SPW"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03779">
        <property type="entry name" value="SPW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="150" mass="15839" checksum="C3388A0A1213BADF" modified="2015-07-22" version="1">MSNQQHTTEMTSHPDVVEMRDRLDRTAARGGVIALEGLILLAGLFAAISPWVVHFTGNTNLTINNLIVGIAVALIGLGLALAPERTSGLAWLTIPLGAWLVISPWVVTVTNGAPTAAIWANCFVGGVTALLGLLAMGLTVAFKRQARTRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NA17</accession>
    <name>A0A0F7NA17_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MDMPI_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_16550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016857.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_16550"/>
    <dbReference type="EnsemblBacteria" id="AKH83552">
        <property type="protein sequence ID" value="AKH83552"/>
        <property type="gene ID" value="AA958_16550"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_16550"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3483"/>
    <dbReference type="OrthoDB" id="1400891at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017517">
        <property type="entry name" value="CHP03083_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024344">
        <property type="entry name" value="MDMPI_metal-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036527">
        <property type="entry name" value="SCP2_sterol-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11716">
        <property type="entry name" value="MDMPI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55718">
        <property type="entry name" value="SSF55718"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03083">
        <property type="entry name" value="TIGR03083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MDMPI_N" evidence="1">
        <location>
            <begin position="15"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="274" mass="30110" checksum="98ED45A772FABC6F" modified="2015-07-22" version="1">MTVHSSLQPSIDAWAHSAEAISELVAPLSEGEWSGRSGLPGWSVRDVVSHIIGAECEALGDPRPIHNLPADLMHITSEKARYVEVQVDTRRHHTAPEMTADLEYTLIRRRRQLRDEKRALDAKVRGAFGSEMTLAELTHYRAFDIWVHEQDIRRALGKPGNIDSPGAHLVRDELLARLPKVVAEDAAARPGSIVVVDVTGPVEFMRTVRVGEDGRGSIDGSVSLGPTVTLTTDWETYLWLATGRLRAAAAADRVKVEGDAHVAETVLRHFSVTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAE7</accession>
    <name>A0A0F7NAE7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AA958_17375</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016991.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_17375"/>
    <dbReference type="EnsemblBacteria" id="AKH83687">
        <property type="protein sequence ID" value="AKH83687"/>
        <property type="gene ID" value="AA958_17375"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_17375"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3654"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="352"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="385"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="412"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="438"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="12"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="280"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="291"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="314"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AKH83687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="483" mass="50168" checksum="8C7B0BA65D37BB1D" modified="2015-07-22" version="1">MTVPDQVLGGRYRLVRQLGEGGMGHVWEARDETLGRPVAVKVISLLAGGGSRGDEARARFLREARITARLQHPGIVTIHDLGETGSGSERVPFLVMELVRGEGLDAKLRRGAVTLQDAARWGAEISDALAEAHSAGVMHRDIKPSNILVMPSGIVKVLDFGIARAADPSATADRLTQTGFIVGTPPYMAPEQARGHPEPHSDLYALGCLLFELITGRLPFQAPDTVGYLTAHLTQEPPAPSSVSAGIPSAWDDLVLTLLHKEPGGRCANAAGLSQALRELDRAPESAPTADGSTAILTTPGPTPLTEAGTRPGPRAPRPEPPGRQPGPAGTGTRPDTTPPPPRRSAARTATAVTAFLCLVLVQVIPFATTQAVDTGEMTSGERTAHVTIFGALAALLIIGMLFLTRHGAGRWLIAAAGAGLALQAANAMIIFDAIGTALQGVLPLAAATAALSAILAVLPATSLSPRHTGEARPRRSAGGRDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAH1</accession>
    <name>A0A0F7NAH1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AA958_22370</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH84488">
        <property type="protein sequence ID" value="AKH84488"/>
        <property type="gene ID" value="AA958_22370"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_22370"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4710"/>
    <dbReference type="OrthoDB" id="1891092at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="125"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="258"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="10">
        <location>
            <begin position="30"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AKH84488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="285" mass="30312" checksum="29B73C07CE0824A2" modified="2015-07-22" version="1">MTASTAPARPGPTAPPALGGVGQSARDSMVVAKRNLLRMSRIPEVVIFGLIQPIMFVVLFSYVFGGSMNVGGSTDSDVYREFLMAGIFAQTVTFATAGAGAGIAEDMHKGLIDRFRSLPMARGAVLTGRTLADLVQTALTLVVLALVAALVGWRFHEGLPKALAAFALLLLLGYAFTWVGALIGLSVRTPEAATSGGLVWLFPVTFVSNAFVDSSRMTPWLQHIADWNPFSATVQACRELFGNPGVSPSDAWPMQHPVLASLIYSVAIIALFRTLAVRKYRNSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAP1</accession>
    <name>A0A0F7NAP1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hydrolase TatD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_28905</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018833.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_28905"/>
    <dbReference type="EnsemblBacteria" id="AKH85600">
        <property type="protein sequence ID" value="AKH85600"/>
        <property type="gene ID" value="AA958_28905"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_28905"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6090"/>
    <dbReference type="OrthoDB" id="915852at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012022">
        <property type="entry name" value="UCP005295"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42658">
        <property type="entry name" value="PTHR42658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005295">
        <property type="entry name" value="UCP005295_TatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="264"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR005295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH85600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="285" mass="31730" checksum="D581A7FD41B72B8A" modified="2015-07-22" version="1">MRIFDPHIHMTSRTTDDYAAMYDAGVRALVEPSFWLGQPRTSPESFYDYFDSLLGWEPFRAAQYGIAHHCTLALNPKEANDPRLLPVLDELPRYLLKDHVVAVGEIGYDSMTPEEDHALAAQLELAADHGLPAMVHTPHRDKAAGLARTLDVVRESRLAPERVILDHLNETTVAAARDSGCWAAFSIYPDTKMDEDRMVRILREYGTERMLVNSAADWGKSDPLKTRKTADAMLAAGFTDADVDKVLWQNPVEFYGQSGRLELEPEKPEAGGATYEGNSILRGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NB48</accession>
    <name>A0A0F7NB48_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Signal peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_23790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017980.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH84728">
        <property type="protein sequence ID" value="AKH84728"/>
        <property type="gene ID" value="AA958_23790"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_23790"/>
    <dbReference type="OrthoDB" id="1741894at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014124">
        <property type="entry name" value="Pept_S26A_Sod_Ni_maturase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015927">
        <property type="entry name" value="Peptidase_S24_S26A/B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00717">
        <property type="entry name" value="Peptidase_S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02754">
        <property type="entry name" value="sod_Ni_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S24" evidence="1">
        <location>
            <begin position="19"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="144" mass="16121" checksum="E8DFBC66E982B561" modified="2015-07-22" version="1">MQGQVNERRHDAGRRGLQRLGLAAVDGPSMVPTLRPGDQLVVQYGVEVRPGDVAVLCHPFQQDLLIVKRVVERRDGGWWVLGDNRFVENDSREFGAVPDELVVARALLRLRPPRGLQRSVRSVPAAVSWAASAVRPLAWRFRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NB85</accession>
    <name>A0A0F7NB85_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_30080</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018993.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_30080"/>
    <dbReference type="EnsemblBacteria" id="AKH85765">
        <property type="protein sequence ID" value="AKH85765"/>
        <property type="gene ID" value="AA958_30080"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_30080"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6351"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="9"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH85765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="405" mass="43877" checksum="B461F15E100D8D56" modified="2015-07-22" version="1">MADLLDGRYLLHEKLGRGMFGTVHRAELRVLGHTLRQVGVKLFHAERAVPVPELLGEALQSIEVVEKCPDPVVRDRFLTCLDAGVEDGAAGRPYMVTELARGDLAWRLRGGQLPVATVRDYARQLCQGLAFLHGQGVVHLDLKPGNILVSASGSLKIGDFGLARRVSAVLRRAPAAGGTVWYVPAEVLQLQEAGPEADVYALGLICYQMLTGRLPHQDQLRAAAPDEVTAPDTDTLVRLKLRDAEPPGIRNPEVRGHPFEAVVMRAVSPLATDRYPDAGALLRALDDPAGAPPPRALTPRQRLETLTEHLRGALRRGDLDLADELRREALDLNRALPDTAMVPEVYALATEAALRRDEGGEARALAMEGLGRRRCPETFRAMAAAFAGTELGRGFARRSGEGAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBB7</accession>
    <name>A0A0F7NBB7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_23985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018015.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_23985"/>
    <dbReference type="EnsemblBacteria" id="AKH84763">
        <property type="protein sequence ID" value="AKH84763"/>
        <property type="gene ID" value="AA958_23985"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_23985"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5055"/>
    <dbReference type="OrthoDB" id="1626703at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="21"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="157" mass="17279" checksum="921F3F786B695752" modified="2015-07-22" version="1">MATTDTAAEAPGTEDEFRKLDEFLCFALYSAQRAVMNAYRPLLDKLGVTYPQYLVLVALYENGPSLVKSLGAALHLDYGTLTPLLKRLEANGLVTRERRADDERLVEVSLTPEGTELRRRANVVVPSLDEAMGLTAEEQEEAKALLRKMSANLAAHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBE2</accession>
    <name>A0A0F7NBE2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_30470</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 3">Membrane</location>
            <topology evidence="1 3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I subunit 4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_30470"/>
    <dbReference type="EnsemblBacteria" id="AKH85825">
        <property type="protein sequence ID" value="AKH85825"/>
        <property type="gene ID" value="AA958_30470"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_30470"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6439"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010227">
        <property type="entry name" value="NADH_Q_OxRdtase_chainM/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003918">
        <property type="entry name" value="NADH_UbQ_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43507">
        <property type="entry name" value="PTHR43507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01437">
        <property type="entry name" value="NUOXDRDTASE4"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01972">
        <property type="entry name" value="NDH_I_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="74"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="207"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="345"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="383"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="420"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="468"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="5">
        <location>
            <begin position="129"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH85825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="505" mass="52708" checksum="8BAAF980DA44D004" modified="2015-07-22" version="1">MTAPVLTAIVFVPAAAAGALLCVPRAAGRRVFLLAWAAVSAAVLALTVALWLGYDPGGGIQYETNARWIPSAGIGYHIGVDGLSLPLLALTAVLFPACALYALRETRRVREFAALFLFLETTCLGLFASLDLILFFVFFDLSIVAMYFVIAGWGHPGAARAAQKFFLYTFSGSLALLLGFIGLYLAATPHTFDIVALAGENPLAGRSGYGALVLLAIGLGLAVKTPTVPFHTWLPPAHTEAPAAGSAILAGVLLKMGTFGFLRIAMPLLPGSWRTYAAVFVVVGVVSVLYGALVALAQTDFKRMIAYTSVNHMGYILLALGAAAALGEETAAARRLAVTGATYQMVSHGLLTGALFLLAGVLHERGRTYAMGAYSGVAARAPAFAALTGVAVFASLGLPGFSGFIAEFQILAGSLGPRPVATALAVLGILLTAALLVRALQRIFLGPLRLPDSPGTPRPFPDLRAHEAAAIVPLLALAVVLGVFPRFVLDVIEPFSRGVLELVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBE6</accession>
    <name>A0A0F7NBE6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_27970</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018670.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_27970"/>
    <dbReference type="EnsemblBacteria" id="AKH85436">
        <property type="protein sequence ID" value="AKH85436"/>
        <property type="gene ID" value="AA958_27970"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_27970"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5895"/>
    <dbReference type="OrthoDB" id="859573at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519274" evidence="1">
        <location>
            <begin position="23"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_4" evidence="2">
        <location>
            <begin position="42"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH85436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="358" mass="37534" checksum="29A59C9D139CDEAE" modified="2015-07-22" version="1">MRRLASFALAGILATGALTACAEEPGSPGDDGEGGGTGAGKVAFLMPDLASTRYEQYDAPLFKKRMGELCDECKVIYQNADSDAALQQQQANSAMAQGAKVIVLDPVDSESAATIVQTAQSQGVKVIAYDRPIPTKPADFYVSFDNEAIGESIGQSLVDHLDKESAEGGILQVNGSPTDAAAGLIKKGIHNAVDDSGYKLLAEYDTPDWSPEKAQQWVSGQISQYSGRIAGVVAANDGTGGGSIAAFKAAEAQVPPVTGNDAELAAVQRIIAGDQYNTISKPIKTVAEAAAEVTYAFMQGEKPKADTELFDTPSQLFEPTVVTQENLKEVIFGPDGVLKAEDVCTREYAKDCQSLGIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBK8</accession>
    <name>A0A0F7NBK8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_20030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017382.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_20030"/>
    <dbReference type="EnsemblBacteria" id="AKH84092">
        <property type="protein sequence ID" value="AKH84092"/>
        <property type="gene ID" value="AA958_20030"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_20030"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4219"/>
    <dbReference type="OrthoDB" id="816674at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH84092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="423" mass="45623" checksum="42DE0E6BDEA98D9D" modified="2015-07-22" version="1">MNCPHAAGSAAAPAASGALPEPLAIDPLVRDLAGETALLCAAAPLTRIELLGAPAWTVTRHAEARRLLTDARLVKDIGAWRLWQTGEVTAEWPLIGMVNPGRSMFTVDGAEHRRLRAKTAQAITPRRLDALRPVVERVTAELLDSLAAAAAGGDGVVDLKEVFAQPLPMRVVCALMGVAESEIPRQMRLWKAFFSMLTPQEERLAVMAELDRVFTDMVRQKTAEPADDLTSALILADEGGEPLTEEEVVGNLKSMIAAGHETTITLLLTTVRGLLSHPEQLALVREGKVTWETAIEEALRYDPPVTHLLMRFATEDIEIAGTVIEKGEGVVISYRAIGRDAGHHGADVDAFDVTRATPIRHMTFGHGPHICPGAALSRLEAAVALPALFARFPELRAAVPLGELRNLPVLTQNDLESFPVRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NC36</accession>
    <name>A0A0F7NC36_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_21090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017552.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH84272">
        <property type="protein sequence ID" value="AKH84272"/>
        <property type="gene ID" value="AA958_21090"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_21090"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4441"/>
    <dbReference type="OrthoDB" id="1927273at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519396" evidence="2">
        <location>
            <begin position="29"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH84272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="217" mass="23433" checksum="D0D5C81EFAF25979" modified="2015-07-22" version="1">MSPRAFSAAALAATAALSLLLTACGSDGEDGDTKPDDKIQGADKPKESPSPTAEEAADRPEIKLPEDVRVVADWSETGKPAEDAILRDTEQRIAAIEMALAEQDPTHAAFRFYSEGEAAAATEEYVKAYVDEEARLTGTIRLYEPTVTIRDDGTATLVYCEDQSKAFDKYLKTGEVNKTPVTKNSYFSHGATLRKDEQGTWVTMTDVTTQGASSCQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NC62</accession>
    <name>A0A0F7NC62_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cysteine desulfurase</fullName>
            <ecNumber evidence="4">2.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AA958_25440</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[sulfur carrier]-H + L-cysteine = [sulfur carrier]-SH + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:43892"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="EC" id="2.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.7" evidence="4"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018254.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_25440"/>
    <dbReference type="EnsemblBacteria" id="AKH85003">
        <property type="protein sequence ID" value="AKH85003"/>
        <property type="gene ID" value="AA958_25440"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_25440"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5362"/>
    <dbReference type="OrthoDB" id="839689at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044571">
        <property type="term" value="P:[2Fe-2S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010240">
        <property type="entry name" value="Cys_deSase_IscS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016454">
        <property type="entry name" value="Cysteine_dSase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11601:SF34">
        <property type="entry name" value="PTHR11601:SF34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005572">
        <property type="entry name" value="NifS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotran_5" evidence="8">
        <location>
            <begin position="5"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH85003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="396" mass="40564" checksum="99F9B1630A78C5F4" modified="2015-07-22" version="1">MDQAVYLDHAATTPMLPEAVRAMTERLTATGNASSLHAAGRRARRTVEESRERLAAAFGARPSEVVFTSGGTEADNLAVKGLYWSRRAEDPARTRVLASPVEHHAVLDAVHWLQKHEGATVDWLPVDTYGRVHPDGLRAALERGPGGGAGDVALVTAMWANNEIGTVLRVAELAAVAREYGVPMHSDAVQAAGQAEIGFGASGLAALTLTGHKIGGPYGIGALLLGRGYAPEPLLHGGGQEREVRSGTLDVPAVAAFAVAAELAAERRAEFAAEVGALRDALVAAVRAAVPDAVLNGDPDPAGRLPANAHFSFPGCEGDSLLLLLDAQGIACSTGSACTAGVAQPSHVLLAAGADPDLARGTLRFSLGHTSTEADVAALAAAIGPAVERARAAGLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCJ2</accession>
    <name>A0A0F7NCJ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Gas vesicle protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_32785</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May play a structural or regulatory role in gas vesicle synthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Vacuole</location>
            <location evidence="2">Gas vesicle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Vesicle</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019432.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_32785"/>
    <dbReference type="EnsemblBacteria" id="AKH86205">
        <property type="protein sequence ID" value="AKH86205"/>
        <property type="gene ID" value="AA958_32785"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_32785"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6927"/>
    <dbReference type="OrthoDB" id="1869432at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031411">
        <property type="term" value="C:gas vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031412">
        <property type="term" value="P:gas vesicle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009430">
        <property type="entry name" value="Gas-vesicle_GvpL/GvpF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36852">
        <property type="entry name" value="PTHR36852"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06386">
        <property type="entry name" value="GvpL_GvpF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0304">Gas vesicle</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH86205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="257" mass="27563" checksum="A83F69E5D8D3BA6D" modified="2015-07-22" version="1">MAPSPLYVYAVVHADLALPLGLRGVGRPPAPVRLLPAGELAAVVSDVPHDLRARRRDLTGHQDLLLALCAAAPVLPMRFGMVADDEETVRSALDAAAATHLDTLRRLDRRTEMNLKAMPAQGGVEALVRDDPAVRRLAADVRRRPTYEGNVRLGSAIAEGLARRAARAADGVAQELAVLADERVQGAEVPGCVLNTSYLMPHAHAERCRELVDRRAAELRDLVELRLTGPLPCYSFVPREGGRAAAGTAPRPVAVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCT0</accession>
    <name>A0A0F7NCT0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Histidine kinase</fullName>
            <ecNumber evidence="4">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AA958_26985</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="4"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018515.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_26985"/>
    <dbReference type="EnsemblBacteria" id="AKH85279">
        <property type="protein sequence ID" value="AKH85279"/>
        <property type="gene ID" value="AA958_26985"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_26985"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5678"/>
    <dbReference type="OrthoDB" id="1293707at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038318">
        <property type="entry name" value="KdpD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025201">
        <property type="entry name" value="KdpD_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003852">
        <property type="entry name" value="Sig_transdc_His_kinase_KdpD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13493">
        <property type="entry name" value="DUF4118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02702">
        <property type="entry name" value="KdpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="383"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="413"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="462"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="626"/>
            <end position="837"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AKH85279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="853" mass="90769" checksum="46864BB7A94CFB89" modified="2015-07-22" version="1">MTRGKLRIYLGAAPGVGKTYAMLSEAHRRLERGTDVVVGFVEHHDRPRAEVLLHGLEQIPRRELDYRGTRFTEMDVDAVLARRPTVVLVDEMAHTNVPGSRNEKRWQDIKELLSAGIDVISTVNIQHLESLGDVVENITGVRQRETVPDAVVRKAGQIELVDMSPEALRRRMAHGNIYDPGKIDAALSNYFRPGNLTALRELALLWVADRVDDYLREYRSEHDIRDTWQARERIVVGITGGPEGRTLIRRGARLATKGAGGEIMAVYISRSDGLTPLNTAPPEELAVQRTLVEDLGGTFHHVIGDDVPDALLEFARGVNATQIVLGSSRRKAWQYAFGPGVGATVARESGPDLDVHIVTHGEVAKGRGLPLARGARLGRGRIAAGWLVGLAGPVLLTAVMLRLDSTLGLANEVLLFLFATVLAALLGGTLPALASAGAGSLLLNYYFTPPVETFTIADARNIVALVVFFAVAVAVASVVDLAARRTSQAARLRAESEVMSLLAGSVLRGEGSLESLLDRVRETFGMESVSLFERQRGEDGWTCVGRVGASAGAPAGPDDADADMPVGDDMTLALTGRKLPAADRRVLGAFAAQAAVVLERQRLAAEAVEARKLAEGNRIRTALLAAVSHDLRTPLAAIKAAVTSLRSDDVAWSEEDEAELLTAIEEGADRLDALVGNLLDMSRLQTGTVTPLLREVDLDEVVPKALAGVPEGSVTLGIPETLPMVTVDAGLLERSVANVVENAVKYSPPGTPVLVQASALGDRVELRVVDRGPGVPDSGKDRIFEPFQRYGDAPRGAGVGLGLAVARGFAEALGGTLVAEDTPGGGLTMVLTLRAAPGRGTPAPAELPAQATT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7ND42</accession>
    <name>A0A0F7ND42_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_33790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019602.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86380">
        <property type="protein sequence ID" value="AKH86380"/>
        <property type="gene ID" value="AA958_33790"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_33790"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.7136"/>
    <dbReference type="OrthoDB" id="1526822at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="328" mass="33819" checksum="BB3AA2D336B014B9" modified="2015-07-22" version="1">MEIAVVRDAAPAAAAWRAVVAAARAADLPGVPAPVREEVLAGLRGDAHAGGTMPPAWAATGAEGEVTAVAGVRPASPGPARTAADLQLYVHPAARRRGTGTLMLAAVAAAAREGGWSALRAAAPACTPADVFCLRHGFVRERVVHHLLLPLAEVHRAWLAELVYADHPGYRLTTWYAPAIPASGPPEPRTGGAPAAAEDPGGLAAAVPGFAFGTGSGVPEPGSGRLLTVAALHTGTGAVAGYTEVLIPPAPAPRAQHCHLAVVPAHRRRGLGRWITAELLRRLHAEHPQVSEVETAAADGDGAILALGEQLGFRPYRRTHDYRLHLPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7ND78</accession>
    <name>A0A0F7ND78_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribonucleoside-diphosphate reductase subunit beta</fullName>
            <ecNumber evidence="3">1.17.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_23640</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>[thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-diphosphate + H2O = [thioredoxin]-dithiol + a ribonucleoside 5'-diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23252"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="EC" id="1.17.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 5">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="3 5">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 3">Genetic information processing; DNA replication.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the ribonucleoside diphosphate reductase small chain family.</text>
    </comment>
    <dbReference type="EC" id="1.17.4.1" evidence="3"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017957.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_23640"/>
    <dbReference type="EnsemblBacteria" id="AKH84702">
        <property type="protein sequence ID" value="AKH84702"/>
        <property type="gene ID" value="AA958_23640"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_23640"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4982"/>
    <dbReference type="OrthoDB" id="1384440at2"/>
    <dbReference type="UniPathway" id="UPA00326"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009263">
        <property type="term" value="P:deoxyribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01049">
        <property type="entry name" value="RNRR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033909">
        <property type="entry name" value="RNR_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000358">
        <property type="entry name" value="RNR_small_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409">
        <property type="entry name" value="PTHR23409"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00268">
        <property type="entry name" value="Ribonuc_red_sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000355">
        <property type="entry name" value="NrdB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000355-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000355-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH84702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="339" mass="38959" checksum="E3D1D50BF2EFBBFD" modified="2015-07-22" version="1">MTTATGAKNLLDPGFELTLRPMRYPDFYERYRDAIKNTWTVEEVDLHSDVSDLAKLSPGEQHLIGRLVAFFATGDSIVANNLVLTLYKHINSPEARLYLSRQLFEEAVHVQFYLTLLDTYLPDPDERAAAFAAVENIPSIREKAQFCFRWMDSVENIERLETREDRRRFLLNLICFAACIEGLFFYGAFAYVYWLRSRGLLHGLATGTNWVFRDESMHMDFAFSVVDTVREEEPGLFDEELGRQVRDMLDEAVRAELQFARDLCGDGLPGMNTDSMRAYLECVADQRLARLGFAPVYGSQNPFAFMELQDVQELTNFFERRPSAYQVAVEGSVGFDDEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7ND93</accession>
    <name>A0A0F7ND93_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_00060</name>
        <name evidence="2" type="ORF">AA958_00255</name>
        <name evidence="3" type="ORF">AA958_34200</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_00060"/>
    <dbReference type="EnsemblBacteria" id="AKH86450">
        <property type="protein sequence ID" value="AKH86450"/>
        <property type="gene ID" value="AA958_00060"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86457">
        <property type="protein sequence ID" value="AKH86457"/>
        <property type="gene ID" value="AA958_00255"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH87228">
        <property type="protein sequence ID" value="AKH87228"/>
        <property type="gene ID" value="AA958_34200"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_00060"/>
    <dbReference type="KEGG" id="strc:AA958_00255"/>
    <dbReference type="KEGG" id="strc:AA958_34200"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.13"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH86450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH87228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="184" mass="19997" checksum="0DF8CC62D533E93B" modified="2015-07-22" version="1">MSVVLRQGRHVVLFRRGGMRVPSVMGLLEARESAARVRVEELRAEADRVRVELVEAEAVLGRRVVALAELAEVLAAGAVLQEPVGPAPVPVEVKEPVAGSVVPVWREGVTVEVLAPEYRRLLAVLEAGSVGQGLRARDLAARLGLELVPSKVEGVRVKAKRLVARGWLAEERPGLFVLRCRRSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDJ0</accession>
    <name>A0A0F7NDJ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_24120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018039.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_24120"/>
    <dbReference type="EnsemblBacteria" id="AKH84787">
        <property type="protein sequence ID" value="AKH84787"/>
        <property type="gene ID" value="AA958_24120"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_24120"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5083"/>
    <dbReference type="OrthoDB" id="1752728at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="10"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="306" mass="31748" checksum="3AADEC5E45F3ED75" modified="2015-07-22" version="1">MKAIITDSYGGVENLRLDEVPKPKVGPDQVLVRVKAAGVNPVDWKVAKGWLDPMMYVRFPLIPGWDAAGVVEELGADTPEFAVGDEVLGYVRRDEVGQGTYAEYVAAPVRTLTHKPAALGWQQAAALPLAGLTALRSLDRVGAGDGETVLVHGGAGGVGSLGVQLAVLRGARVIATASERNHDFLRSLGAEPVTYGEGLADRVRELAPGGVDAAVDFAGGGAVQVSHDVLKDPARSASVADGEVKKLGGQVVWVRPDAEGLAHLAGLAAAGTLTVHVDALPLAEAAEAFRRSESGRTRGKLVLDVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDK5</accession>
    <name>A0A0F7NDK5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_28350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018738.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_28350"/>
    <dbReference type="EnsemblBacteria" id="AKH85504">
        <property type="protein sequence ID" value="AKH85504"/>
        <property type="gene ID" value="AA958_28350"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_28350"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5975"/>
    <dbReference type="OrthoDB" id="1283559at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="256" mass="27476" checksum="D85182A4F9286598" modified="2015-07-22" version="1">MPESVPVRCPACRREHAYTPSTFPCACGAPLTLPLLRGGVPVELKHRTWQDSWVTVRCPVCDRRDEWPRPELSCDCGAVVRLPVAPVQSRRPRPAAPPVPPAPAAAPPAPAPPGPPRRPAAAPAPRRPAFRPVTIRNTGDAVTAAAQYLRWLGFTDLVKNEDRPASGVDVRGAGVVAHVDPTTTPTALRHVECVWLSGLNASALAVFFSLAGYTREARTRADELRLPLYVMDLTGTPQPVNDPGDELIRTGAAPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDQ2</accession>
    <name>A0A0F7NDQ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_33595</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019568.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_33595"/>
    <dbReference type="EnsemblBacteria" id="AKH86346">
        <property type="protein sequence ID" value="AKH86346"/>
        <property type="gene ID" value="AA958_33595"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_33595"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.7094"/>
    <dbReference type="OrthoDB" id="972769at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="3">
        <location>
            <begin position="10"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH86346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="329" mass="34542" checksum="8A97AC05FF13AF80" modified="2015-07-22" version="1">MRAAVIEAPGTVTVTDVPDPSPGPREVVVDVAACGLCGTDLHILQGEFAPTLPVVPGHEFAGEVVGIGRDVTEVAVGDRVAVDPSLYCHECRKCRTGHGNLCERWGAIGVTVAGGAAEYAVAPVANCVRLPDHVRTQDAALIEPLSCAVRGYDVLNSKLAAHVLIYGTGTMGLMMLELAKRTGAAAVDVVDLNPERLATARKVGCSRAAATPEEFGQPEGWDVVIDATGNAAAIQDGLGRVGKAGTFLQFGVADYATTATIEPYRIYNQEITITGSMAVLHSYERAAELFAADVLDPELLISDRLPLEQYPAALEQFASGKGRKIVVVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NE01</accession>
    <name>A0A0F7NE01_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Molybdopterin molybdenumtransferase</fullName>
            <ecNumber evidence="7">2.10.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AA958_12345</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 7">Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenylyl-molybdopterin + H(+) + molybdate = AMP + H2O + Mo-molybdopterin</text>
            <dbReference type="Rhea" id="RHEA:35047"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
            <dbReference type="ChEBI" id="CHEBI:62727"/>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.10.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 7">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 7">Belongs to the MoeA family.</text>
    </comment>
    <dbReference type="EC" id="2.10.1.1" evidence="7"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_12345"/>
    <dbReference type="EnsemblBacteria" id="AKH86710">
        <property type="protein sequence ID" value="AKH86710"/>
        <property type="gene ID" value="AA958_12345"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_12345"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2594"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061599">
        <property type="term" value="F:molybdopterin molybdotransferase activity"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032324">
        <property type="term" value="P:molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00887">
        <property type="entry name" value="MoeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038987">
        <property type="entry name" value="MoeA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005111">
        <property type="entry name" value="MoeA_C_domain_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036688">
        <property type="entry name" value="MoeA_C_domain_IV_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005110">
        <property type="entry name" value="MoeA_linker/N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036135">
        <property type="entry name" value="MoeA_linker/N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10192">
        <property type="entry name" value="PTHR10192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03454">
        <property type="entry name" value="MoeA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03453">
        <property type="entry name" value="MoeA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="SSF53218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63867">
        <property type="entry name" value="SSF63867"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63882">
        <property type="entry name" value="SSF63882"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00177">
        <property type="entry name" value="molyb_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="6 7" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MoCF_biosynth" evidence="9">
        <location>
            <begin position="199"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="380"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AKH86710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="451" mass="46498" checksum="1B5F1F45182424CA" modified="2015-07-22" version="1">MWSVDEHIDDILRQIRPLEPLEMQLLDAQGCVLVEDVTAAVALPPFDNSSMDGYAVRTVDVEGASDEFPAVLRVVGDVPAGGGAELPHVGAGEAARIMTGAPLPPGTQAVVPVEWTDGGTGRGRVDAMRPHSESPAGAGGAVRIYEPARTGRYVRTRGSDVLAGDLVLRAGTVLGPAQIGLLAAIGRGTVRVRPRPRVVVLSTGSELVPPGEQLAPGRIHDSNSYALTAAARDAGAIAYRVGAVADDAETLRATVEDQLIRADALVTSGGVSVGAYDVVKEALAELDGEAGGGVEFRRLAMQPGKPQGFGRIGADRTPLFALPGNPVSAYISFEMFVRPVIRRLMGVEPVQRPVVRARLAGTETLTSPAGRRQFLRGWYEHEPADGGTDPAGTDSGVPGPGGPGGPGAVTPVGGSGSHLIAALARANALVVVPEETTEVTPGAPVDVVLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NE42</accession>
    <name>A0A0F7NE42_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AA958_25245</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018218.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_25245"/>
    <dbReference type="EnsemblBacteria" id="AKH84967">
        <property type="protein sequence ID" value="AKH84967"/>
        <property type="gene ID" value="AA958_25245"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_25245"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5320"/>
    <dbReference type="OrthoDB" id="643917at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="53"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="198"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="54"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="378"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="411"/>
            <end position="418"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AKH84967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="618" mass="67090" checksum="BF735123F9806428" modified="2015-07-22" version="1">MTATVTERPGGEEPDDDRPRPRTDPFDRDLLPAPDGASRTLLGSLLAPHRRRVAAATVLILLQQAAVQAGPLLVAYAIDHAVPALRRDDHGPLIAVGIAYAVCALASGLLQHTFVRAAARINQDVLLDLRGRIFRHAQALDVDFHDRYTSGRLISRSTSDVESLRELLSEGLQELIVVVLQVVYISALLLWLDLGLGGAALLSFVPLYLLIRNFQRRSIKIYTKRSTAIAQVIVKFVETMNGIRPVQAFRRERANDEDFDRLNGHHEQVNGDSILEMARYVVCSRLTANVFVAAIVLWGAYRVAEDDLALGVLAAAVLYLRRLYDPIDRLGMFLNSYQSAAASLQKIAGLLAQRPGVAEPAEPRPLPARQEGLPGREVRFEGVGFSYRTGGEVLPRFDLTVPAGQTVAVVGSTGAGKSTLAKLLARFYDPSAGRVLLDGVDLREIANAELRRGVVMVTQEAFLFSGTVAENIAIGRPDATREEIEAAAKALGAHEFITALPDGYDTDVRKRGGRISAGQRQLVAFARALLADPAVVILDEATSSLDIPGEQAVQEAMQTVLHGRTAVVIAHRLSTVEIADRVLVMSQGRIVEDGPPATLIADRGRFAALHQAWQDSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NEF2</accession>
    <name>A0A0F7NEF2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glycosyl hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_29925</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in degradation of plant cell walls. Hydrolyzes the feruloyl-arabinose ester bond in arabinoxylans, and the feruloyl-galactose ester bond in pectin. Active against paranitrophenyl-acetate, methyl ferulate and wheat arabinoxylan.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the faeC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018971.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_29925"/>
    <dbReference type="ESTHER" id="9actn-a0a0f7nef2">
        <property type="family name" value="FaeC"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH85743">
        <property type="protein sequence ID" value="AKH85743"/>
        <property type="gene ID" value="AA958_29925"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_29925"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6319"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030600">
        <property type="term" value="F:feruloyl esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043595">
        <property type="entry name" value="FaeB/C/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034429">
        <property type="entry name" value="FaeC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38050">
        <property type="entry name" value="PTHR38050"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38050:SF1">
        <property type="entry name" value="PTHR38050:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14200">
        <property type="entry name" value="RicinB_lectin_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="SSF50370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519455" evidence="5">
        <location>
            <begin position="45"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B-type lectin" evidence="6">
        <location>
            <begin position="50"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH85743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="457" mass="48052" checksum="BBA4266E6995365A" modified="2015-07-22" version="1">MKTYGAVSSAPPRRHRWWSRIAAVVAAALAIGMLAVVNPAPAAAATVDTNAWYVLVNRTSGKALDVSGVSTADGARVSQWTRHDGANQQWQFVDSGGGFYRLKARHSGKVLDVSGASTADGAAIQQWADHNGANQQFRLADSDAGHVRLINRNSGKAVEVQDGSTADGANVVQYADWGGANQQWQMVKLSSDGGGGGCGSPPTLTSGTHTIQSGGKSRSFILRVPANYDNSHPYRLIFAFHWRGGTAGEVASGGTSGTAWSYYGQQEQSNNSAILVAPQGLGNGWANSGGEDVTFVDDMIRLIEGDLCVNTAQRFATGFSWGGGMSYALACSRANVFRAVAVISGAQISGCSGGTQPIAYFGIHGISDSVLNIAQGRSLRDKFVGNNGCTPQSPREPAPGSRTHITTTYTGCRAGYPVQWAAFDGGHIPGPVDGSPNESGVTTWTKAEIWRFFAQFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NEU6</accession>
    <name>A0A0F7NEU6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Xylose isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_31395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019202.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_31395"/>
    <dbReference type="EnsemblBacteria" id="AKH85974">
        <property type="protein sequence ID" value="AKH85974"/>
        <property type="gene ID" value="AA958_31395"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_31395"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6634"/>
    <dbReference type="OrthoDB" id="1007505at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="21"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="266" mass="28727" checksum="B1825D7EDA6F9B1B" modified="2015-07-22" version="1">MFSLAAQEQLLPGDTLQQKWEFAQAAGYDGIELRAQGDLRFAARLPELKHALADGVVMPTVCVEMLHFFGDFDAGRRRDAVAQMKSQLSVIAEIGGVGAQTPASYGMFSRRLPPFTPPRDEAGDRAVLLDGLAELGEHARREGVTLFLEPLNRYEDHMVNRLAQATELIRAAGLDSVRIGIDSYHMNIEEADPAAAILDNAPWIGHAQVSDSNRFQPGAGHLDWPAWLGALRAAGYTGWLAAECRLTGDPAAAVAAVPGFLRRAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NF25</accession>
    <name>A0A0F7NF25_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_18290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020191.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86866">
        <property type="protein sequence ID" value="AKH86866"/>
        <property type="gene ID" value="AA958_18290"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_18290"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3844"/>
    <dbReference type="OrthoDB" id="1582456at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="249" mass="26273" checksum="FBAD787C9272FE0F" modified="2015-07-22" version="1">MKTVLITGTSSGYGRATALHFHAQGWNVIATMRTPRAGVLPESDRLRVVELDVTKSASITAALEAAGPIDVLVNNAGVPSISVFEGTPMTEVREVFETNTFGVMATSQAVLPQFRERGSGVVVNVTSSVVMGHMPLSAVYKASKMAIEGFTSSLALELAPFGVQAKTVEPGACLTTNFATRATKGASLDALVPAPYAAWAKKAMDSFTGQDLFTKETDVAEAVWRAVHDTTGQLRFPAGPDAVWLAQAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NF33</accession>
    <name>A0A0F7NF33_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_18715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020206.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86876">
        <property type="protein sequence ID" value="AKH86876"/>
        <property type="gene ID" value="AA958_18715"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_18715"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3924"/>
    <dbReference type="OrthoDB" id="1930919at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="214" mass="23745" checksum="E3944A8D6EA7BBA9" modified="2015-07-22" version="1">MSQARVPYLLGHAEIASLFTVERQTSQKWRTEGTLPEPDLVASGNPYWLLTTVLQISGGDREADQQQLATYRAGIPEGYDVQDREHLPVVLGIQEVGRVLGKDAQAVSRWRNRRRIAEADLILSGSPLWLLETMLIDARQRQRTIVPAEVARLRAGRRAPQKPRGRRQYTPAAPPPREPLPGARAFSAADQPAAAEFLASVLAQGYSVVIKPQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-08-12" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFB7</accession>
    <name>A0A0F7NFB7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Anti-sigma factor antagonist</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_31755</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the anti-sigma-factor antagonist family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019261.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86033">
        <property type="protein sequence ID" value="AKH86033"/>
        <property type="gene ID" value="AA958_31755"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_31755"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6705"/>
    <dbReference type="OrthoDB" id="1864829at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043856">
        <property type="term" value="F:anti-sigma factor antagonist activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003658">
        <property type="entry name" value="Anti-sigma_ant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00377">
        <property type="entry name" value="ant_ant_sig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="3">
        <location>
            <begin position="24"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH86033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="143" mass="15590" checksum="2632754B99D9FC55" modified="2015-07-22" version="1">MYTDDVTGASWRTGDDHADRVESRFARSYRLRGFTVLELTGEIDLAAQLDLEPYLDVITGAPAPRVVIDLCRTEFLDCSGLRLLVRARRRTADRGGELRLVCPEGGLAHRILRCCGLLDALGPVPTLADALPGENPEAVASQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFG9</accession>
    <name>A0A0F7NFG9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Proteasome subunit beta</fullName>
            <ecNumber evidence="3">3.4.25.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">20S proteasome beta subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Proteasome core protein PrcB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">prcB</name>
        <name evidence="5" type="ORF">AA958_28005</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>Cleavage of peptide bonds with very broad specificity.</text>
            <dbReference type="EC" id="3.4.25.1"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="3">The formation of the proteasomal ATPase ARC-20S proteasome complex, likely via the docking of the C-termini of ARC into the intersubunit pockets in the alpha-rings, may trigger opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein degradation; proteasomal Pup-dependent pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped by the proteasome-associated ATPase, ARC.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase T1B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.25.1" evidence="3"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018676.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_28005"/>
    <dbReference type="EnsemblBacteria" id="AKH85442">
        <property type="protein sequence ID" value="AKH85442"/>
        <property type="gene ID" value="AA958_28005"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_28005"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5902"/>
    <dbReference type="OrthoDB" id="1129370at2"/>
    <dbReference type="UniPathway" id="UPA00997"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019941">
        <property type="term" value="P:modification-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02113_B">
        <property type="entry name" value="Proteasome_B_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000243">
        <property type="entry name" value="Pept_T1A_subB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022483">
        <property type="entry name" value="PSB_actinobac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00141">
        <property type="entry name" value="PROTEASOME"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03690">
        <property type="entry name" value="20S_bact_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0645">Protease</keyword>
    <keyword evidence="3 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0888">Threonine protease</keyword>
    <keyword evidence="3" id="KW-0865">Zymogen</keyword>
    <feature type="propeptide" id="PRO_5005028141" description="Removed in mature form; by autocatalysis" evidence="3">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023574700" description="Proteasome subunit beta" evidence="3">
        <location>
            <begin position="57"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3 4">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600243-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH85442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="285" mass="30203" checksum="B4C8529A0676173E" modified="2015-07-22" version="1">MEESTKGTAVEQLPPEFLTPGSSSFVDFLAAHAPDQLPANRPLPGTGAAAVDIPHGTTIVAASYADGVLLAADRRVTLGNGMIAHRDFEKVFPADEFSAVGIAGSTGMAEEMVRLFRLELEHYEKIETVPLSLEGKANRLGTLIRDNLGPAMQGLAVVPLFAGYDPRSGTARIYSYDITGGRAEEKGFGGTGSGSVFARGALKKLYREGMSRDDAVTMAVQALYDAAEDDSATGGPDATRRIYPLVYTVTAEGCRRLDDDRVSELSLAVLEGRRGRPDGPNAPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFQ1</accession>
    <name>A0A0F7NFQ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_32420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019375.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86148">
        <property type="protein sequence ID" value="AKH86148"/>
        <property type="gene ID" value="AA958_32420"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_32420"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6843"/>
    <dbReference type="OrthoDB" id="1744037at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="21"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="168" mass="17157" checksum="8DC0BDDA6B45F1AA" modified="2015-07-22" version="1">MTSERTGRTAPAAATSVDAGPAALASALVRLTHTLQHVLAEAGRDHGLTPQQVQLLCALSSGPVGMSELSRWLRLGKSGLTGLVDRVERRGLVARIPDADDGRACRIALTAAGEELAGRAHAGVTARIAAMAAGLAAGERAALTDAVARLLDAAPCQSPSPEAWPEQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFU5</accession>
    <name>A0A0F7NFU5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_33440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019543.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_33440"/>
    <dbReference type="EnsemblBacteria" id="AKH86319">
        <property type="protein sequence ID" value="AKH86319"/>
        <property type="gene ID" value="AA958_33440"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_33440"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.7062"/>
    <dbReference type="OrthoDB" id="751534at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013108">
        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07969">
        <property type="entry name" value="Amidohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro_3" evidence="2">
        <location>
            <begin position="72"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH86319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="561" mass="57352" checksum="2AD1810EC02C0546" modified="2015-07-22" version="1">MTADRPAARPAEAANSVPSRAGSARRTVLLRGGTVHSPADPFATAMVVEGDRVAWVGSEGAADGFAGAADEIVHLEGALVTPAFTDAHVHLTATGLALTGLDLSGATGLADALARIRAYAAERPADRVLIGQGYDETGWPEGRPPARAELDEAAGGRPLYLTRVDVHSAAVSTALLDLVPGVAGRDGYAADAPLTRDAHHAVRRAAYAAMSPAQRAAAQGAALDRAAAVGIGSVHECAGPDISGEDDFAALLALAAERPGPRVTGYWGEAVTGPADARRVRELGAFGAAGDFCADGSLGSRTAHLTQPYADRPGHRGNGYLDAAAVAAHVAACTEAGLQAGFHAIGDAAVAAVVAGVRAAAERVGLDRVRALRHRVEHAEMLTAETVAGFAELALTASVQPAFDAAWGGEEGMYARRLGAERARALNPYAALLRAGVPLALGSDAPVTPLDPWRTVQAAAFHRTPEHRISARAAFTAHTRGGWRAVGRDDAGVLVPGAPADYAVWAAGDLVVQVPDERVANWSTDPRSGTPGLPDLTPGAELPVCLRTVVAGNTVHPGPIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFW9</accession>
    <name>A0A0F7NFW9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alkaline phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_33215</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_33215"/>
    <dbReference type="EnsemblBacteria" id="AKH87206">
        <property type="protein sequence ID" value="AKH87206"/>
        <property type="gene ID" value="AA958_33215"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_33215"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.7016"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd07389">
        <property type="entry name" value="MPP_PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018946">
        <property type="entry name" value="PhoD-like_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038607">
        <property type="entry name" value="PhoD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032093">
        <property type="entry name" value="PhoD_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09423">
        <property type="entry name" value="PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16655">
        <property type="entry name" value="PhoD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PhoD_N" evidence="2">
        <location>
            <begin position="25"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="PhoD" evidence="1">
        <location>
            <begin position="135"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH87206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="497" mass="54384" checksum="82B315B50D7355EC" modified="2015-07-22" version="1">MAAAAQFTPAPAAAAPRYHDNPFTLGVASGEPLPHGVVLWTRLAPVPLAEDGLGGMPPQDVAVRWEVAEDPGMRRVVRRGTAAARRDFAHSVHVEVTGLRPGREYWYRFRTGGELSPVGRTKTAPAAGSLTPMTLALATCQSWSDGFYTAYRHLASQDVDLVAHLGDYIYEYPVGRTSGPRGTDLSAAHNAETLTLDQYRLRYALYRTDPDLQAAHAAAPWIVTVDDHDVEDNWSDETSFSGASPEDLLRRRAAAFRAYYEHLPLRASSLPQGPDMRLHRTLDYGGLARFHVLDARQFRDPIDITRRDDPARSMLGAAQERWLLDGLADSGAVWNVLTQQVLMMQLDRLTDPGLQQLNGDAWDGYTATRNRLLDGIAERRVANPVVLTGDMHVNMAGTVKRDFTDPSSPAVAPEFVTTSITSGGNGADSGPQAGEWLAANPHLSFYNGQRGYVRCTVSPGEWRADYLVVDKVSVPDGAVSTRRSFVVEAGRPELQEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NG39</accession>
    <name>A0A0F7NG39_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_29660</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018936.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_29660"/>
    <dbReference type="EnsemblBacteria" id="AKH85707">
        <property type="protein sequence ID" value="AKH85707"/>
        <property type="gene ID" value="AA958_29660"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_29660"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6262"/>
    <dbReference type="OrthoDB" id="1688736at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="183"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="289"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="96"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH85707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="323" mass="35935" checksum="27EA83CD01381B64" modified="2015-07-22" version="1">MTAPARTEPDTTAAHEATGAPAPVPGGTAIRHGRFEHGLMFVAPFLALYALFLVWPVVLGIKMSLTSDNITGSGGEYVGFDNYTEALSDPDMWEALWQTVWFTLLSTVPLVLLGLVMALLAHGLRFVDWLWRLSWFAPYLLPSGVVGLLWLWIIYPADFGLADQLLAEFGLHPGIGWLTDPQYAMLSIVITTIWWTVGFNFLLYLAALQSIPQHLYEAAELDGATAWQRLWHITLPMLRRTTGVVVILQLLASLKIFDQVYIMTQGGPDGATRTTLLYVFEEGFTGYRIGYASAASYIFFALIVLVSLIHLHLARRTRQESTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NGN4</accession>
    <name>A0A0F7NGN4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_30880</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019115.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_30880"/>
    <dbReference type="EnsemblBacteria" id="AKH85887">
        <property type="protein sequence ID" value="AKH85887"/>
        <property type="gene ID" value="AA958_30880"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_30880"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6526"/>
    <dbReference type="OrthoDB" id="1024978at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="2">
        <location>
            <begin position="4"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH85887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="489" mass="50150" checksum="15319859C634AB57" modified="2015-07-22" version="1">MNDSSSVAQLVAVLRDELSRYSEGEKLPSSRALVARHRVSPVTVSRAIAALTAEGLVTSRPGAGVFKAPVRAPARALGDVSWQEVALTADPPYAAVDTGPRAADAAGVLATLAAPPAEVVDLSGGYPHASLRPERALAGALARAGRRPGTWSRPPVAGLAELRDWFARDIGGPAGPLGAADVLVTAGGQSGLTTALRALAAPGSAVLVESPTYPGLLAVARAAGLRPVPVPLDADGVRADLLAEAFAATRARVFVCQPLFHNPTGAVLAPGRRAAVLRTARAAGAFVVEDDFARRLAHADAAPLPPALAADDPDGVVVHVRSLTKAASPSLRVGALSARGPVLERLRAVQVVDSLFVPRPLQETALELVGSPAWASHLRALAGALRERRSAVLAALHAELPGLVPDRPPLGGYHLWLRLPDGADEAAVAAAALRHGVAVTPGAPYFTAEAPAPHLRLSYAAGSGTAQLREGVRRLRRAFPADSPLAGGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NHK1</accession>
    <name>A0A0F7NHK1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_15065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020082.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_15065"/>
    <dbReference type="EnsemblBacteria" id="AKH86783">
        <property type="protein sequence ID" value="AKH86783"/>
        <property type="gene ID" value="AA958_15065"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_15065"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3174"/>
    <dbReference type="OrthoDB" id="1473468at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="1">
        <location>
            <begin position="18"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="285" mass="30309" checksum="FA437704E4941167" modified="2015-07-22" version="1">MTVGNCGVETVYERPPERAVTLNQHVTEIMLALGLEKSVVGTGYLDDEILPAYRGAYAGIEVIADEYPSYETLLAAEPDFVYGGFASTFEEGRGRDALAGAGIDSYLSLEACAEPPVTVDLMDREIRTVAEVFGVPRRAEKLLGELHGTLDGVRDAVAGVEAAEVFVYDSGDKTAFTAGGGGIGNEIIGLAGGANVFAGLGKPFGDVSFEQVAARAPDAIVIYDYGDQSVADKKRFLLSHPALQDVPAVRNERFAVLPLSSTVLGVRVPEAVDSLARQLHPDRFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NHK6</accession>
    <name>A0A0F7NHK6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_15260</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020088.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_15260"/>
    <dbReference type="EnsemblBacteria" id="AKH86788">
        <property type="protein sequence ID" value="AKH86788"/>
        <property type="gene ID" value="AA958_15260"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_15260"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3214"/>
    <dbReference type="OrthoDB" id="1853974at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027381">
        <property type="entry name" value="LytR/CpsA/Psr_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13399">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LytR_C" evidence="2">
        <location>
            <begin position="105"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH86788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="222" mass="23127" checksum="15115C94F60B5A6B" modified="2015-07-22" version="1">MLTPPEMGGPYRIKGTKYPRMRRSRRRRRVLALLGAVLAVAVVGWGTLQLVDAFTGGGEDEEKAAQARTPGDCGAGDTGAKSGEGKRPERGPGEKPAELPAPGRVEVNVLNATARTGLAQKTADELKKRGFKIGKVDNAPAAYDKKVRGEGVLLGAPGTVDGELKVLGTQLAQAEPKAVEREGAVVDLIIGDEFRGLTEPAEAKAALKALTAPAKAKPGACE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-12-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NHN1</accession>
    <name>A0A0F7NHN1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_15995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020115.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86813">
        <property type="protein sequence ID" value="AKH86813"/>
        <property type="gene ID" value="AA958_15995"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_15995"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3370"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="117" mass="11917" checksum="6C1090EC9B624956" modified="2015-07-22" version="1">MGVAARRGTGTGLGGCALALFGAVVAPLAWAPRAAVSVRGGFEGHARDLSVLYVDLPLVVLGGALLPPGVWALGLRWVGRPWVAAVAAVVALGLGVWGLTEWWSPRRAPDPGYGPGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NIU8</accession>
    <name>A0A0F7NIU8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">LysM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_32350</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_32350"/>
    <dbReference type="EnsemblBacteria" id="AKH87193">
        <property type="protein sequence ID" value="AKH87193"/>
        <property type="gene ID" value="AA958_32350"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_32350"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6829"/>
    <dbReference type="OrthoDB" id="1891666at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519699" description="LysM domain-containing protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="3">
        <location>
            <begin position="85"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH87193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="365" mass="36958" checksum="E1EBDA48D5D86852" modified="2015-07-22" version="1">MSRASLTVTASGAGLALPLVAGAAAPAAGTPADALHSPAKDRAQEGLKPPSDGALSDRADTETAADGSAAAPQGGRAGTVGKKPGHHEVASGETLSGIADQHRVRGGWPALYERNRGVVGADPDLILPGQRLTLRGGAAAPPKPRADSPAAGKKKSGDDGAKAAGTKSRQSQEKAKSGGKAKPEKAKPKAKPAKSKPDRTKPDAKKRAPAPQAEAEAEAKPKPKPEAKPAADYTSPLAGASIGTPYGASGSSWSSGYHTGVDFPVPVGTGVRSVADGEVVSAGWAGAYGYEVVIRHRDGRYSQYAHLSAVTVSAGRPVNAGQRIGRSGSTGNSTGPHLHFEVRTGPGYGSDVDPLRYLRGRGVRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NJA7</accession>
    <name>A0A0F7NJA7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Polyprenyl synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_18610</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_18610"/>
    <dbReference type="EnsemblBacteria" id="AKH86872">
        <property type="protein sequence ID" value="AKH86872"/>
        <property type="gene ID" value="AA958_18610"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_18610"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3904"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH86872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="374" mass="40012" checksum="513D1F8369A906EA" modified="2015-07-22" version="1">MTAKENVVFRPPAGLTRTTGEKDGAEPAADPGAATGQLLTRVSARIEDLLAAERKTWDDVDARMTRPIDAIAHLVAAGGKRLRPTFCISGYLAAGGVLDGSQAEDAVVSAGAALELLHAFALIHDDVMDNAPTRRGRPTVHMRHAAVHADQGWAGEPRRYGDGAAIIAGDLAYGYAHTAVEALSGPARRVWNHLGTEMIFGQQLDMSLAAELVPDPALARYVAVCKSGQYTIHRPLALGAVIAGRDDLDDAFEAYGVAAGEAFQLRDDLLDAFGDPEVTGKPAGLDIRQHKMNLLLALAATKDAEVARLVADGGDWDADRLHEALRASGMREEVEQRIEDLVSTAHKALEDAPLAPGWRERLKEMAVKVAYRET</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NJN6</accession>
    <name>A0A0F7NJN6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Arginine ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_23830</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_23830"/>
    <dbReference type="EnsemblBacteria" id="AKH86997">
        <property type="protein sequence ID" value="AKH86997"/>
        <property type="gene ID" value="AA958_23830"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_23830"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5022"/>
    <dbReference type="OrthoDB" id="1191583at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015424">
        <property type="term" value="F:ABC-type amino acid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030679">
        <property type="entry name" value="ABC_ATPase_HisP-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039085">
        <property type="entry name" value="ABC_ATPase_HisP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH86997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="253" mass="27996" checksum="84EFBBA8FF3BD33B" modified="2015-07-22" version="1">MTAMVRAEGVHKSFGLTHVLKGIDLEVAPREVFCLVGPSGSGKSTFLRCINHLEKINAGRLYVDGHLVGYRQQGNKLYELKEREVAAQRKDIGMVFQRFNLFPHMTALENVMEAPVQVKRESKATARERALRLLDRVGLADKAGGYPTQLSGGQQQRVAIARALAMEPKLMLFDEPTSALDPELVGEVLDVMRDLAESGMTMIVVTHEMGFAREVGDALVFMDDGAVVESGHPRDVLTNPQHQRTKTFLSKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MXT7</accession>
    <name>A0A0F7MXT7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_01515</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014425.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_01515"/>
    <dbReference type="EnsemblBacteria" id="AKH81060">
        <property type="protein sequence ID" value="AKH81060"/>
        <property type="gene ID" value="AA958_01515"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_01515"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.333"/>
    <dbReference type="OrthoDB" id="1309478at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH81060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="194" mass="20052" checksum="65D669542A954B58" modified="2015-07-22" version="1">MPLSVLTPPSPALRSVNAALKSPTAVRGTRALAPVSGSPADATDALPVHVLAGVGAADGTPRAALTGWRFHLAAEGRVVAAAEARITPDGWAFSHFSEGPYVASTQRALRQAESLPALLQPRLLSVPELYMVTLWLRADVTAPAESGTVDPADLLVPLAPAPPGIRAHRAHRAGDLLPALRDRLAGVRLLGSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MZM9</accession>
    <name>A0A0F7MZM9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_02105</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014525.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH81161">
        <property type="protein sequence ID" value="AKH81161"/>
        <property type="gene ID" value="AA958_02105"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_02105"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.453"/>
    <dbReference type="OrthoDB" id="1714516at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005183">
        <property type="entry name" value="DUF305"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03713">
        <property type="entry name" value="DUF305"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002518920" evidence="2">
        <location>
            <begin position="26"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="DUF305" evidence="3">
        <location>
            <begin position="70"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH81161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="217" mass="22624" checksum="9DDB67DA1EF72AC2" modified="2015-07-22" version="1">MRHPRALASVVPLTAALLLAGCTGGDSSDDAGDGGKASVIAPGKPGEEASRIPADQVEEARGDDRPNAADTTYMRDMIEHHGQAIVMTGLAEKRAGAEGVRGIAERIAAGQQPEIAVMEAWLEENQGGGEDGHDGGHAGGHEAMPGMASEADLGRLRAARGEEFDALFLKLMIAHHEGAVEMAEEVLGKGNNEYVEQLATGVIAQQLSEIGRMEKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MZU9</accession>
    <name>A0A0F7MZU9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha-mannosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_02510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014594.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_02510"/>
    <dbReference type="EnsemblBacteria" id="AKH81231">
        <property type="protein sequence ID" value="AKH81231"/>
        <property type="gene ID" value="AA958_02510"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_02510"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.537"/>
    <dbReference type="OrthoDB" id="299689at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004559">
        <property type="term" value="F:alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011682">
        <property type="entry name" value="Glyco_hydro_38_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000602">
        <property type="entry name" value="Glyco_hydro_38_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027291">
        <property type="entry name" value="Glyco_hydro_38_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07748">
        <property type="entry name" value="Glyco_hydro_38C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01074">
        <property type="entry name" value="Glyco_hydro_38N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_38N" evidence="1">
        <location>
            <begin position="140"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_38C" evidence="2">
        <location>
            <begin position="699"/>
            <end position="848"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH81231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="1080" mass="116045" checksum="D10A587ADA4E3E58" modified="2015-07-22" version="1">MTTRALVKTTDWDNDRIRDSLRGSVVSAEGSLAGTALRLTQEPLLKHAEGGGLLQSLRVEATGGPLPAELAAGSSTAFVVRTESGTALPAVPEAGPGGSVRLLLPAVDTATRVTVGLAADPDAGADAGIVLTLTPQRQWTLHLVHHSHLDIGYTDPQGRVLAEHLSFLDSCLELTRATDDWPAESRFRWCVESLWSFRQWADARPAEQVEEFVRRVREGRIELTAMPFNLHTETCSTDELHELLRLADEVRDEHGVEFTSAMQTDVPGAVVGLVDALAAAGVRYLSVAHNWAGRSVPHLVGGEKLPRLFRWRAPSGNSILVWVTDTPHGLAYMEGPLLGFDTDYDSVDDLLPAYLTSLASNPYPYRGGIFGWAMDQADVKREPYPWDILHLRVQGKFGDNAPPRRIIADTVRRWNETWAYPQLRLSRNEDFFTDAEARLGDEIRTFEGDWTDWWVDGVGSGARPLSLARTAQATVADAQTLGTFAGILGATGAADDSRDAAPVYEAVSLFDEHTWGAGDPWTHGDHGGHSGEEQWHWKYGQALRAYDDGNSLLDRARARLGQRLAGAPDAVSYHVVNTCSWARTDVVRIFLPESSVPLEQRVAVRDARTGEKLRHEEQAQVNDDHRDAGRFLLVCVADVPPAGSVRLDVVAEGAGDGAADGEGTVLKAATGWNPTGGTEKEDPAETAAAAHAQADPTLLENEHLAVRVDLARACIASVVDKTTGRELVRGADAGAAAGFNAYIHDSYTTAGGFNHNSSRTTASERLEHLGNRSVAPPAALIARTSTATGETLTYETRPAGANRVRTTLTLPHGAARLDIENRVDKDATPGKESAYFAFPFAFEAPTVRMEATGGATGTGLSVIPGSARHMRAVRRWVTLADDGLAVAWATQDAPLVQFGNIALPYAPFPKTMGEDEPATVFSWIHNNLWDTNFPSEQGFEFTFRYSLACGTDAAAPHGSLGARTAAGLSRPLHAVRARAPHAEGPEVTDGLAFAEVGDPRVRLVGATTPGGEAGEGAVLLRLQSFAEEPVACPVRALFPVTGAGLADYLGRPGDDLPVTDGEVTVDLPTLGTTAVLFRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MZV8</accession>
    <name>A0A0F7MZV8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_02565</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014604.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_02565"/>
    <dbReference type="EnsemblBacteria" id="AKH81241">
        <property type="protein sequence ID" value="AKH81241"/>
        <property type="gene ID" value="AA958_02565"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_02565"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.549"/>
    <dbReference type="OrthoDB" id="1734230at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="107"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="278"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="105"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH81241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="312" mass="32722" checksum="B745231691CC45AA" modified="2015-07-22" version="1">MAEAPEAPEAPRAVRKPGMSAAGRPDTTRWRTRGTGRKSVRALRVRTSAAVVALAVLAVLVVPPLVQLDQQAVDIGNKLAAPSLSHLFGTDDVGRDVLLRCVYGLRVSLLVGVVAALVATVVGTAIGALAGALGGHVDRAVMRLVDVFASVPHLLLGIFIVALFQPGVWPVVASVGLTHWVSTCRIVRAEVLSLRGRPFVDAAVSGGASRTRVAIRHLVPGVLPQAGLAAVLMVPHAIWHESALSFLGLGLPPHQASLGAMVQGARGSLLAGDWWPTLFPGLFIIIPTLAVAGLAGAWRERLNPRRRSELTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N1J5</accession>
    <name>A0A0F7N1J5_9ACTN</name>
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            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">AA958_06165</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81861.1"/>
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    </dbReference>
    <dbReference type="RefSeq" id="WP_047015214.1">
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    </dbReference>
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        <property type="protein sequence ID" value="AKH81861"/>
        <property type="gene ID" value="AA958_06165"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_06165"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1288"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021215">
        <property type="entry name" value="DUF2752"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10825">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519690" evidence="2">
        <location>
            <begin position="25"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH81861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="144" mass="14086" checksum="DD22B34422AFF37C" modified="2015-07-22" version="1">MSARTAATAPLRRLAPPLAALACAAAGLAAVGAADPNEPGRYPPCPVLAYTGLACPGCGGLRCAYALAHGDAAGALGANALAAAGAAVLGVALLGWLLAAVRPLPRALPRIRIPARLPVGPVLFALVAAFTLLRNLPFGAALGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N1K9</accession>
    <name>A0A0F7N1K9_9ACTN</name>
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        <submittedName>
            <fullName evidence="2">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_06260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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    <dbReference type="EnsemblBacteria" id="AKH81876">
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        <property type="gene ID" value="AA958_06260"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_06260"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1309"/>
    <dbReference type="Proteomes" id="UP000034283">
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    </dbReference>
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        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
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        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="32"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="290" mass="32490" checksum="C9EB7E9D046E7DD7" modified="2015-07-22" version="1">MTRRRTWGFADVSKPRELHPDRSARDLYGSEVRRYRNNAGMSLEALSGVVMYSRAHLSRIETAEAIPPPDLSEKLDACFGTDGHFGRLYGVARREIHPDQYRRRMELEARAVAIVHYAPFVIPGLLHSERYARAIFTVCNPSAPAGSIDDLVTARLSRRDILKGEKPARLSLILEESAITRTIGGPGVMHEQLRSLLTWVESRSSLVQVLPHSHGAHALLGGTLALWTLDNGTAVAYEESITTGHLIEDPEKIRWWAQACDVLRAYARSPAETAEFIRSVMEELPDEHHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N1M3</accession>
    <name>A0A0F7N1M3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_09795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015818.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_09795"/>
    <dbReference type="EnsemblBacteria" id="AKH82475">
        <property type="protein sequence ID" value="AKH82475"/>
        <property type="gene ID" value="AA958_09795"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_09795"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2064"/>
    <dbReference type="OrthoDB" id="1864858at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041581">
        <property type="entry name" value="Glyoxalase_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18029">
        <property type="entry name" value="Glyoxalase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="8"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="137"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="265" mass="28131" checksum="FFC9F6C0606FE87C" modified="2015-07-22" version="1">MTVRPEGAPTWADATFPDLEAAKSFYADVFGWTFEDGGEASGHYTQAMAESGVAAGLAPPMPGAEEAPAGWTLYFATPDADATATHVGEHGGRVLMGPMEVGPYGTMAIAEDPDGIRFGLWESGSHEGFAAIGEPGTFCWAEVDTNNPAHADEFFPEVFGYRVRKMQDDTMDYAVWSVGDGDPLIGRAEMSGNVFPAGTPPHVGVCFAVNDCDRAVETTRRRGGSVTFGPQDSPFGRMATLEDPQGASFTVIDVNRTVGDMPEFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N1V0</accession>
    <name>A0A0F7N1V0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Universal stress protein UspA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_10410</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015912.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_10410"/>
    <dbReference type="EnsemblBacteria" id="AKH82570">
        <property type="protein sequence ID" value="AKH82570"/>
        <property type="gene ID" value="AA958_10410"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_10410"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2192"/>
    <dbReference type="OrthoDB" id="2040681at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="3">
        <location>
            <begin position="40"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH82570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="173" mass="18470" checksum="11CED3901C732E4B" modified="2015-07-22" version="1">MAGHEFPEPADRKPVADPTADLEAAAEPRQGCDPAFKHGVVCGFDGSMSSERALAYAVGMARRLGCGLIIVHVANRLPTTVWAGCEPPVFVDVPDHRTEVLGLELACADYLSDVPWILVERGGDICHELEEVGREYEADAIVVGSTQGIVGRIFGSVAGRLARRAQRPVVVVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N222</accession>
    <name>A0A0F7N222_9ACTN</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">AA958_00605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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    </dbReference>
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    </dbReference>
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        <property type="gene ID" value="AA958_00605"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_00605"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.141"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045701">
        <property type="entry name" value="DUF6059"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19534">
        <property type="entry name" value="DUF6059"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH80912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="86" mass="9221" checksum="70843C8133F67165" modified="2015-07-22" version="1">MVAALAWLLRALQEALTSLGRVWFFIPPAPPVSPPPPPPPPPGPAPGHPERLRPDVPLTEQEEALRRQLDDIALPDAIGEEKSPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N278</accession>
    <name>A0A0F7N278_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase C14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_11210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH82705">
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        <property type="gene ID" value="AA958_11210"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_11210"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2362"/>
    <dbReference type="OrthoDB" id="1340956at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05050">
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransf_21" evidence="2">
        <location>
            <begin position="69"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH82705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="331" mass="36117" checksum="9AD38EAEDF43996F" modified="2015-07-22" version="1">MPLAVRTPVNPAAPPGTGAYPRALNVLSRKETAVQRQLRRAGLAGYEPLTQATLLTVAQFAPPHAAVYDIGAHIGLYAALVDLVHGAKRLQTVAFEPTPRTAKLCRRLRDGNRLAFDVRQMALSDRSRTAELYLSLKAESSNSLNPAHRAHTEAVRVPVGTVDGFAEQHGHAPYLLKIDVETHEPEVLAGAAGVLREHRPWIVCEVLPSTDPAAMAAALSHLTELGYGLHLIHPGTPWPAHDATSYAPHVQGECRDWLFAPEPLTDEFYAAQRAWLRAVLACGKEENVLVPPGEPFPRDWNAPHGAPGAPPRPRRGLEARLPRMWRQAVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2C5</accession>
    <name>A0A0F7N2C5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Membrane dipeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_11480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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        </lineage>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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    <dbReference type="EnsemblBacteria" id="AKH82750">
        <property type="protein sequence ID" value="AKH82750"/>
        <property type="gene ID" value="AA958_11480"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_11480"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2416"/>
    <dbReference type="OrthoDB" id="1145595at2"/>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF01244">
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
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    </dbReference>
    <dbReference type="PROSITE" id="PS51365">
        <property type="entry name" value="RENAL_DIPEPTIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH82750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="402" mass="43859" checksum="16447DAC527FD56C" modified="2015-07-22" version="1">MNGELLARAREVLRAHPVVDGHNDLPWALREQVTYDIDRRDIAVDQSARLHTDLPRLRAGGVGAQFWSVYVSADLAGDAAVSACLEQIDVVRRLVDRYPGELRLAVTADEVEAARADGRIASLMGAEGGHSIANSLATLRAFRRLGVRYMTLTHNDNTDWADSATDEPRHGGLTAFGEEVVREMNRVGMLVDLSHVAPSTMRHALRVTEAPVVFSHSSARALCDHPRNIPDDVLEMLPANGGVAMATFVPKFVLPAAVEWTAEVDEHMTARGLDPFGADDEAVRVRRAFEEAHPRPQATAATVADHLDHMREVSGIDHIGIGGDFDGTPFTPEDLADVAGYPHLVAELLHRRWSEEDLARLLWANALRVLRDAEAAAREVAARRGPSIATIEQLDGPVKVQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2D6</accession>
    <name>A0A0F7N2D6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_01275</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
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        <lineage>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014387.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH81022">
        <property type="protein sequence ID" value="AKH81022"/>
        <property type="gene ID" value="AA958_01275"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_01275"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.281"/>
    <dbReference type="OrthoDB" id="1437290at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041347">
        <property type="entry name" value="MftR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17754">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="6"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH81022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="190" mass="20934" checksum="887772AC687CB7D5" modified="2015-07-22" version="1">MPRWESDAQGRLERAALELFETQGFERTSVAQIAGAAGLKERSFYRYFPDKREVLFAGNELEAHLVAQVEAADPGLTPIEALLTALGTAEEVFRSREFLLRRGRVIAANPALAERDLVKLADIADALAPALERRGVEPGKARFIIDVVLAIHRRAMPRWLAEPDTTLAQLMAQAAAELREVVAPPAPTNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2F2</accession>
    <name>A0A0F7N2F2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_11845</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH82810">
        <property type="protein sequence ID" value="AKH82810"/>
        <property type="gene ID" value="AA958_11845"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_11845"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2490"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="76" mass="7980" checksum="2BD04BC25F0D3814" modified="2015-07-22" version="1">MDGGSTADVLDAVGPPSAHARGLRDLTLPPGGAAEFDTSVPHWLGSADGGTVELLILFDLRGVRTHVRTDPKRHQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2V8</accession>
    <name>A0A0F7N2V8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_02225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_02225"/>
    <dbReference type="EnsemblBacteria" id="AKH81182">
        <property type="protein sequence ID" value="AKH81182"/>
        <property type="gene ID" value="AA958_02225"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_02225"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.478"/>
    <dbReference type="OrthoDB" id="1356861at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013454">
        <property type="entry name" value="Bifunc_RhaD/ADH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="SSF53639"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02632">
        <property type="entry name" value="RhaD_aldol-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldolase_II" evidence="1">
        <location>
            <begin position="16"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="686" mass="71901" checksum="F58D128BE7FDF9E0" modified="2015-07-22" version="1">MGRVSGGAGAYDPVADLLARAHRLGADPRNTNYAGGNASAKGTAKDPVTGGDVELMWVKGSGGDLGTLTAAGLAVLRLDRLRALTGTYPGVDREDEMVGAFDYCLHGRGGAPPSIDTAMHALVGAAHVDHLHPDSGIALACAADGEELTRRCFGERVVWVPWRRPGFQLGLDIAAVHEAHPEAIGVVLGGHGITAWGADSAECERNSLEIIRTAERFLAEQGRPEPFGPLLEGYGPLPEAERRARAAVLAPVVRGLASADRPQVGHFTDGEAVLDFLAREAHPRLAALGTSCPDHFLRTKVRPLVLDLPPDAPAAEAVARLRELHAAYREDYRAYYERHAAPDSPAMRGADPAIVLVPGVGVFSFGKDKQTARVAGEFYVNAINVMRGAEAVSTYAPIAEAEKFRIEYWELEEAKLRRMPPPKPLATRVALVTGAGSGIGRAIARRLAAEGACVVVADRDAAGAEAVAAELGGPDKAVAVPVDVTEEEQIAAAFRAAVLAFGGVDLVVNNAGISVSKPLAETTAADWDTQHAIMARGSFLVSREAARVLAAQGMGGDIVYIASKNGVFAGPNNIAYGAAKADQAHQVRLLAAELGELGVRVNGINPDGVVRGSGIFAGGWGARRAAVYGVPEEKLGEFYAQRTLLKREVLPEHVANAVFALTAGELSHTTGLHIPVDAGVAAAFLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2Y0</accession>
    <name>A0A0F7N2Y0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">zf-HC2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_12965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016319.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_12965"/>
    <dbReference type="EnsemblBacteria" id="AKH82985">
        <property type="protein sequence ID" value="AKH82985"/>
        <property type="gene ID" value="AA958_12965"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_12965"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2729"/>
    <dbReference type="OrthoDB" id="593385at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041916">
        <property type="entry name" value="Anti_sigma_zinc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027383">
        <property type="entry name" value="Znf_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13490">
        <property type="entry name" value="zf-HC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-HC2" evidence="1">
        <location>
            <begin position="13"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="393" mass="42236" checksum="2448CC5FEFFBB737" modified="2015-07-22" version="1">MITGPYDHGRLKSLLGAWALAACAPEETAAVEAHLTDCAPCADEALRLRDAVRLLHPHDNLDMDPALRSRVLELCLTRRMPGIPMPGWSVPYDAEAARLDALLADMNEADWGAPVQLAWYDDDRPAVRETSVAGVIGHLLAVDGLLALALGLPDPLAADAPAAGTHPRTVASPAERTEALWRVAGSSYAEQQSLAREFRRKHASKMRSEWRDQTYTLIRTAGFAGSGVADVQVPYGGGAALPLRDAFLDRAFECWMHAWDIAEAVDYPYVPPTPEHMHPMIDLAARLLPQTLADRRRSGRAAPPRTLVAAGTPGRTLHLEIEGKGGGNWYLPLDSPAAVAGPERAVAHVALEGLEFCRLAAGHVSPAEAAVGSDGEREAVEDFLYATASLSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N312</accession>
    <name>A0A0F7N312_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_09265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015732.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_09265"/>
    <dbReference type="EnsemblBacteria" id="AKH82386">
        <property type="protein sequence ID" value="AKH82386"/>
        <property type="gene ID" value="AA958_09265"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_09265"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1955"/>
    <dbReference type="OrthoDB" id="1054546at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="21"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="336" mass="35535" checksum="D9ECA792469AA268" modified="2015-07-22" version="1">MTTAANPVPSRTLGALESPAIGYGAMVLSPGVYGETDDDRGVAALHAALDAGATHVDSSDGYGPDGHNERLIGRALRGRRDEVVVATKFGLTLPEGVEGRAHPVSYAFGNLTVNAEPRYVRGYAERSLRNLDTDRIDLYYVHFPDPAVPIEDTAGAMAELVAEGKVRHLGLSNVTADELRRAHAVHPVAAVQAQWSMWTPVDPELHAAARELGVGVVAWGPLGTGFLTGSVTDVAESDFRRNIGAFDAANLKANHDRFAPLRAVAADVGLTPGQLALAWLLHQDDHVVPIPGSRTPAHIEENMAAAHVELHPDTLTRIDEVLAGLAPEGGARLLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3D5</accession>
    <name>A0A0F7N3D5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HATPase_c domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_10290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015893.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_10290"/>
    <dbReference type="EnsemblBacteria" id="AKH82551">
        <property type="protein sequence ID" value="AKH82551"/>
        <property type="gene ID" value="AA958_10290"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_10290"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2168"/>
    <dbReference type="OrthoDB" id="1832160at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HATPase_c" evidence="1">
        <location>
            <begin position="12"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="174" mass="18466" checksum="905B000E6BE11BCB" modified="2015-07-22" version="1">MTASEFAACTLEDDPRSISIARNVARATLRGWQLEDLVDDVASVASELVANALRHGLCEPSWSQAPHPVVLSLLRRGSEVVCAVFDPGTGVPRVCVADPFAESGRGMQIVECLSDSWGWSEPGPYGKAVWARFSEGGRAAAPAEENGVEQPLTRLLVLVEVLTGSSPPQLQAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3H3</accession>
    <name>A0A0F7N3H3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">3-dehydroquinate synthase</fullName>
            <shortName evidence="8">DHQS</shortName>
            <ecNumber evidence="8">4.2.3.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">aroB</name>
        <name evidence="10" type="ORF">AA958_03185</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate = 3-dehydroquinate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21968"/>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="EC" id="4.2.3.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 1 divalent metal cation per subunit. Can use either Co(2+) or Zn(2+).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.4" evidence="8"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014706.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_03185"/>
    <dbReference type="EnsemblBacteria" id="AKH81347">
        <property type="protein sequence ID" value="AKH81347"/>
        <property type="gene ID" value="AA958_03185"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_03185"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.679"/>
    <dbReference type="OrthoDB" id="1677032at2"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003856">
        <property type="term" value="F:3-dehydroquinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00110">
        <property type="entry name" value="DHQ_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016037">
        <property type="entry name" value="DHQ_synth_AroB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030963">
        <property type="entry name" value="DHQ_synth_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030960">
        <property type="entry name" value="DHQS/DOIS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01761">
        <property type="entry name" value="DHQ_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001455">
        <property type="entry name" value="DHQ_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01357">
        <property type="entry name" value="aroB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0170">Cobalt</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8" id="KW-0520">NAD</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="DHQ_synthase" evidence="9">
        <location>
            <begin position="76"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="114"/>
            <end position="118"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="138"/>
            <end position="139"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AKH81347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="375" mass="39166" checksum="5768E185F8806814" modified="2015-07-22" version="1">MTPSAEGAEVTRIHIGGTAGTEPYEAVVGRQLLGELPRLIGERARRVAVLVPEALAEAGEALREDLAGQGYEAVVIQVPNAEEAKTAEVAAYCWRALGQSGFTRSDAVVGVGGGATTDLAGFVAATWLRGVRWVAVPTTVLGMVDAAVGGKTGINTAEGKNLVGAFHPPAGVLCDLAALDSLGVHDYVSGLAEVIKAGFIADPAILELVEADPEGARSPAGPHTAELVERAIRVKAEVVSADLKESGLREILNYGHTLGHAIEKNERYKWRHGAAVSVGMVFAAELGRIAGRLDDATADRHRAVLSAVGLPVTYRGDQWPKLLQTMKVDKKTRGDLLRFIVLDGLAKPAVLEGPDPAMLLAAHAEIAADAGEAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3H7</accession>
    <name>A0A0F7N3H7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NYN domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_06430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015256.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_06430"/>
    <dbReference type="EnsemblBacteria" id="AKH81903">
        <property type="protein sequence ID" value="AKH81903"/>
        <property type="gene ID" value="AA958_06430"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_06430"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1343"/>
    <dbReference type="OrthoDB" id="788525at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021139">
        <property type="entry name" value="NYN_MARF1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01936">
        <property type="entry name" value="NYN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NYN" evidence="2">
        <location>
            <begin position="38"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH81903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="422" mass="45717" checksum="17220D44A8E7B046" modified="2015-07-22" version="1">MDRCVVLVDAGYLLGAAASLLAGEPARSRITVDHPALIQGLRDQAEADTGQRLLRIYWFDGAPDRVPQPEHRRLRVMSRVTVRLGALTRSDGRWAQKGVDAAMHAELTELARNRACADVVLVTGDGDLLPGMMSAKEHGVAVHLWAVQAADGDYNQSEDLVAEADERRVLDRAWITRAMQAKDLTGICAPSPVPRPEIAAILSAPPSETSVAGKQTAVANGTAQATAPVTERRHDDAGTAPDAVPEDEDDPGAKGGVPTPKDLASLGRPAVPEGRHGHPVGNATLRWSSDRGWVERPGAEPPDVAGLPTLAQLTTAEQRWADREEDITVIGGDPFEVGQVFARRWMERLADQAKLRLLAGQYPRIPHRIDGELLRYAARFGLLAHKDDQIDERDRYAIRAGFWREVDVSSAAEHAQAAEPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3I5</accession>
    <name>A0A0F7N3I5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Lipoprotein signal peptidase</fullName>
            <ecNumber evidence="6">3.4.23.36</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Prolipoprotein signal peptidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Signal peptidase II</fullName>
            <shortName evidence="6">SPase II</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">lspA</name>
        <name evidence="9" type="ORF">AA958_06480</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">This protein specifically catalyzes the removal of signal peptides from prolipoproteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Release of signal peptides from bacterial membrane prolipoproteins. Hydrolyzes -Xaa-Yaa-Zaa-|-(S,diacylglyceryl)Cys-, in which Xaa is hydrophobic (preferably Leu), and Yaa (Ala or Ser) and Zaa (Gly or Ala) have small, neutral side chains.</text>
            <dbReference type="EC" id="3.4.23.36"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Protein modification; lipoprotein biosynthesis (signal peptide cleavage).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the peptidase A8 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.23.36" evidence="6"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015266.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_06480"/>
    <dbReference type="EnsemblBacteria" id="AKH81913">
        <property type="protein sequence ID" value="AKH81913"/>
        <property type="gene ID" value="AA958_06480"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_06480"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1353"/>
    <dbReference type="OrthoDB" id="1575081at2"/>
    <dbReference type="UniPathway" id="UPA00665"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00161">
        <property type="entry name" value="LspA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001872">
        <property type="entry name" value="Peptidase_A8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33695">
        <property type="entry name" value="PTHR33695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01252">
        <property type="entry name" value="Peptidase_A8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00781">
        <property type="entry name" value="LIPOSIGPTASE"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00077">
        <property type="entry name" value="lspA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="2 6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH81913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="220" mass="22869" checksum="98E1B774FAC7E3F9" modified="2015-07-22" version="1">MTEAERISGDATEPRGEDEAASAADEKADADTADPAGKATAGDTAAEAGDGVPEAAARGPRRIGVLLGVAALVYALDLVTKLIVVARLEPDNRSVEVVGDLLRFQVVRNAGAAFGIGESMTVIFTLIAVIVIGVIARLARKLYSLPWAIALGLLLGGPLGNLTDRLFRSPGFFEGHVVDFIAPEHFAVFNLADSAIVCGGILIVILSFRGLDPDGTIHRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3S8</accession>
    <name>A0A0F7N3S8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_07125</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015379.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_07125"/>
    <dbReference type="EnsemblBacteria" id="AKH82029">
        <property type="protein sequence ID" value="AKH82029"/>
        <property type="gene ID" value="AA958_07125"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_07125"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1493"/>
    <dbReference type="OrthoDB" id="587274at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="SSF51695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="360"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="392"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="445"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="539"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="485"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="516"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH82029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="859" mass="88066" checksum="162E61467CFC9573" modified="2015-07-22" version="1">MSGARRVWTAVAAALLSALTLLLLCRYTVADPAYYTGAVREADGYQRVYDEVLADPAVRQALRTGALGVPLRSDAVVDNLPLLVPRPVLEQAADRQARALVAALTGSAAAGDDWRGPVTESATEAGSEHLRALRADADPAAARGLTNLITRLRAYVTPGRQSPTPTSALREAVATFVHDTWPPTTARRIMTALDEILPGAEAPHTRTAGAADRGPVPEARPPLVARGDAVGRPGLWSAGRESGAPGGESHGRSAVGTQVRPPLVRAPGSEAPGAEGRGPYAAGARPPLVASGGAPGDGRGGTDGTGGGGPAVGNGRVPLVVEDRAGGGTDPASAASPELPGWGPERGAVVRTVLAASASWWAVAGVAAAAAGAGVLALRAAARGGRLRARTAAAACAGAGVLTAAAGAAVWAALPPSAGLVPDGLPPSVAALLTDVVAGLYREAAVAWAAALLTLTLTAAALATSPTARRTLRLALTRTAGAPAPAAAPGAVPAHPHRAPGDPAPTAAEPGTATGPQPSTAPPPPSRPATPRARWARRLGLGFAGFAALAQIWMLAVVPAGDALACNGDVALCGRPYDRVVQVGAHNAMATVPDGFLGAHQDVSLTGQLDRGARALLLDTHYWETAERLVPPAGTGGLDAASRATLVRAVDSVVRPRPGTWLCHGPCRMGATPLTAQLRELRDWLEEHPRDVVTLILQDAITPRDTARAFRAAGLGPYLHRPGPDPTAPWPTLGEMADSGRRLVVFAEEADGPAPWYRNFYEYAVETPYRAREPGDMSCAPHRGGSDPRKRLFLLNHFVTHGTGAPRAEAAAVNDADAIVHRARTCALLRGRMPTIVAVNHMTLGDAVGAVRRLNSEMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N454</accession>
    <name>A0A0F7N454_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GDT1 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_07855</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the GDT1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015513.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_07855"/>
    <dbReference type="EnsemblBacteria" id="AKH82163">
        <property type="protein sequence ID" value="AKH82163"/>
        <property type="gene ID" value="AA958_07855"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_07855"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1654"/>
    <dbReference type="OrthoDB" id="2050363at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001727">
        <property type="entry name" value="Gdt1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12608">
        <property type="entry name" value="PTHR12608"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01169">
        <property type="entry name" value="UPF0016"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH82163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="193" mass="20078" checksum="5A758666D5F71843" modified="2015-07-22" version="1">MLSLSTVAIVFGVVFLAELPDKTALAGLMLGTRYRASYVFAGVAAAFVVHVSLAIAAGSLLAQLPQRPVQGIVGALFLAGALVLLLKKDDDEEEVKAPADQSFLKVAGAGFMLILVAEFGDLTQIMTANLAARFDDWLSVGIGAVLALWAVAAIGILGGRTLMRYVPLKLITKVAAGVMLVLAGFSIYEAITG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4A2</accession>
    <name>A0A0F7N4A2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Acyl carrier protein</fullName>
            <shortName evidence="1">ACP</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">acpP</name>
        <name evidence="4" type="ORF">AA958_08185</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Carrier of the growing fatty acid chain in fatty acid biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="1">4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the acyl carrier protein (ACP) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015563.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_08185"/>
    <dbReference type="EnsemblBacteria" id="AKH82213">
        <property type="protein sequence ID" value="AKH82213"/>
        <property type="gene ID" value="AA958_08185"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_08185"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1727"/>
    <dbReference type="OrthoDB" id="1943389at2"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000036">
        <property type="term" value="F:acyl carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01217">
        <property type="entry name" value="Acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003231">
        <property type="entry name" value="Acyl_carrier"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20863">
        <property type="entry name" value="PTHR20863"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="1" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="1 2" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="3">
        <location>
            <begin position="3"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="1 2">
        <location>
            <position position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH82213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="82" mass="8902" checksum="6AF6FF6251840B3F" modified="2015-07-22" version="1">MAATQEEIVAGLAEIVNEIAGIPVEDVQPDKSFTDDLDVDSLSMVEVVVAAEERFDVKIPDDDVKALRTVGDATDYILKHQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4Z6</accession>
    <name>A0A0F7N4Z6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AA958_13570</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016421.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_13570"/>
    <dbReference type="EnsemblBacteria" id="AKH83091">
        <property type="protein sequence ID" value="AKH83091"/>
        <property type="gene ID" value="AA958_13570"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_13570"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2856"/>
    <dbReference type="OrthoDB" id="692375at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519195" description="Histidine kinase" evidence="9">
        <location>
            <begin position="31"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="168"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="11">
        <location>
            <begin position="192"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="10">
        <location>
            <begin position="253"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="460"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AKH83091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="485" mass="51762" checksum="95538E1718EEE04A" modified="2015-07-22" version="1">MTSRFGRLPLRSRLALLTAAAMAVAIAAAAVSCWLITRDQLMNEFNRSLRQAEVPNTLPRIVRTGCLDERPPGSPEDLNTDRTTAQIVLPDGRACLLQGEHTIPVTETDQAVAAQGGAQRTEIMHDVTSDGTEWRVRTIGGGLTLNDEPAAISFARPLSEVTDPLNTLALVLALVAGCGVLGAGAIGLGVARAGLRPVERLTHTVEHIARTEDLAVEIPVEGDDEIARLSRSFNAMTAALATSQERQQQLIADAGHELRTPLTSLRTNIELLARSEESGRELPPRQRRELLESVTAQMTELAALIGDLQELSRPDAAPDKAQLAVVALDEIAERAVRRVRLRAPEVRIDAELAPWFVRAEPAALERAVVNLLDNAVKFSPPGSRVEVGLGGDGLLRVRDHGPGIPEAELPHVFERFWRSPSARGRPGSGLGLSIVARTVQQAGGTVALRRAAGGGTEALLRLPGAPEPPPGSLSAIRGRGPHRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N512</accession>
    <name>A0A0F7N512_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidinol-phosphate aminotransferase</fullName>
            <ecNumber evidence="3">2.6.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Imidazole acetol-phosphate transaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">hisC</name>
        <name evidence="6" type="ORF">AA958_06390</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>2-oxoglutarate + L-histidinol phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:23744"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57766"/>
            <dbReference type="ChEBI" id="CHEBI:57980"/>
            <dbReference type="EC" id="2.6.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.9" evidence="3"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015250.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_06390"/>
    <dbReference type="EnsemblBacteria" id="AKH81897">
        <property type="protein sequence ID" value="AKH81897"/>
        <property type="gene ID" value="AA958_06390"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_06390"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1334"/>
    <dbReference type="OrthoDB" id="1248286at2"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00012"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004400">
        <property type="term" value="F:histidinol-phosphate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01023">
        <property type="entry name" value="HisC_aminotrans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005861">
        <property type="entry name" value="HisP_aminotrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01141">
        <property type="entry name" value="hisC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 3 6" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="5">
        <location>
            <begin position="28"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3">
        <location>
            <position position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH81897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="368" mass="40093" checksum="1A2EE3B9DFA47BE0" modified="2015-07-22" version="1">MTAIDDLPVRDELRGKSPYGAPQLDVPVRLNTNENPYPLPEPLVRRIAERVTEAARHLNRYPDRDAVELRTELARYLSRTAGHEVTTAQVWAANGSNEVIQQLLQTFGGPGRTAIGFEPSYSMHALISRGTGTGWLSGPRREDFTIDAGAAERAIAEHRPEVVFVCSPNNPTGTAVDRGTVLRLYEAAQAAGPSMVVVDEAYGEFSHRPSLLPLIEGRPRLVLTRTMSKAFGAAGLRLGYLAADPAVVDAVQLVRLPYHLSAVTQATALAALEHTDTLLQYVEQLKQERDRLVSELTALGCEVTESDANFVQFGRFPDAYAAWQRLLDAGVLVRDNGVPGFLRVSAGTPAENDAFLDAVRALKKESNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N565</accession>
    <name>A0A0F7N565_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptidase M28</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_10130</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M28 family. M28A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015866.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_10130"/>
    <dbReference type="EnsemblBacteria" id="AKH82524">
        <property type="protein sequence ID" value="AKH82524"/>
        <property type="gene ID" value="AA958_10130"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_10130"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2133"/>
    <dbReference type="OrthoDB" id="1465483at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03876">
        <property type="entry name" value="M28_SGAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029514">
        <property type="entry name" value="Ape3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041756">
        <property type="entry name" value="M28_SGAP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="PTHR12147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147:SF17">
        <property type="entry name" value="PTHR12147:SF17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519135" evidence="3">
        <location>
            <begin position="33"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M28" evidence="4">
        <location>
            <begin position="122"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH82524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="333" mass="34448" checksum="49D3F0C878BF807C" modified="2015-07-22" version="1">MPLRRARLRSRPAAALLAGGLLTALLVPAAVAAEPAAQPASGGSTAAPAARVAPEQAPDIPVANVKAHLSQFQSIAAANGGNRAHGRPGYRASLDYVKGKLDAAGFTTRIQQFSAGGGTGYNLIADWPGGDANQVLMAGAHLDSVSSGPGINDNGTGSAAVLETALAVARSGFQPREHLRFAWWGAEELGLVGSRYYVSNLPAADRAALSGYLNFDMIGSPNPGYFVYDDDPQIEKVFKDYYAGLGVPTEIETEGDGRSDHAAFKSAGVPVGGLFTGASRTKSSAQAAKWGGTAGQAFDRCYHSSCDTTSNVNDTALNRNSDALAHAVWTLSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N572</accession>
    <name>A0A0F7N572_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AA958_06765</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glycosyltransferase 87 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_06765"/>
    <dbReference type="EnsemblBacteria" id="AKH81962">
        <property type="protein sequence ID" value="AKH81962"/>
        <property type="gene ID" value="AA958_06765"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_06765"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1413"/>
    <dbReference type="OrthoDB" id="1272007at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018584">
        <property type="entry name" value="GT87"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016570">
        <property type="entry name" value="UCP010361"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09594">
        <property type="entry name" value="GT87"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010361">
        <property type="entry name" value="UCP010361"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="305"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="356"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="388"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH81962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="413" mass="42768" checksum="8E9F6A3C0393F598" modified="2015-07-22" version="1">MARVAAPVAAWALTRAGLLLLVLGVVTLPGPDVTSDVEVIYRGWYEVLRTGTFPVDDVSWQYPPGAALPVLSPGLLPFLGYASAFFALACAADAAVLALLLRAGGGAGRSWAGAWFWVAGVPLLGPTAYARYDVMVTAVAVAALLAAARRPAVAGALAGFGAMLKVWPVLVLLGTARGRATRLSWGAAAGTAAGVALLAAVALPGAFGFVTAQRDRGTEVESLGALVFHVGRHHGWEGTVELHYGSMEFLGPGVGLVSDLALGLSVVAMGWLVLWRLRAREFTATTGCEAAFAGALLFTTTSRVISPQYLLWLVGLAAVCLTLRAARMALPAGLVLAATGVTLAEFPVWFGEVVGSTGFGIALLAFRNGLLVVATVVACRRLWRSTAAPVGPGSGEAAVPRQRTAREDDLLTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5H4</accession>
    <name>A0A0F7N5H4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2Fe-2S ferredoxin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_10925</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015994.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_10925"/>
    <dbReference type="EnsemblBacteria" id="AKH82654">
        <property type="protein sequence ID" value="AKH82654"/>
        <property type="gene ID" value="AA958_10925"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_10925"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2298"/>
    <dbReference type="OrthoDB" id="1843415at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002888">
        <property type="entry name" value="2Fe-2S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036884">
        <property type="entry name" value="2Fe-2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01799">
        <property type="entry name" value="Fer2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47741">
        <property type="entry name" value="SSF47741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="3">
        <location>
            <begin position="352"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="504"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="118"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="280"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="504"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="539"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH82654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="555" mass="55778" checksum="A5C738AE8446FC4E" modified="2015-07-22" version="1">MSREHQDDQQPQYGTGGWQPMPQGADGDPDATAFVQLPPEAFPEADAGAPLAAPGHGYVPPPIAVPATDPGQTGQFQIPEGLSGQTAQEAPETYGHGGAYGYGPEAAGPGPDDGHGGAHGQGHGDQHGDGGARPRRSGAGGFGQAGLRAVAESRRAAANGGTPANGGVAGGGGYAQDGPDGGQSAYGLRLDAGHDGGAQPWADPGYPVDPGTGTWPGAAAHADAGEGPYGEVPPGPAQHPADREGPPAEGQISAWRPVPQDGDTSPGWAIPTAPDDLPEDSGEYALHDRSAGEGQPDGDAREHAAPEADVPLPPETGRAGPVDEPAPEAVPAGTGPEPAPASALAADEHPLASYVLRVNGADRPVTGAWIGESLLYVLRERLGLAGAKDGCSQGECGACSVKVDGRLVAACLVPAATAAGAEIRTVEGLADQGVHSDVQRALAASGAVQCGFCVPGLAMTVHDLLEGNHSPSDLEARQALSGNLCRCTGYRAVLDAVQEVIAGRRAPDTEDDTEGAERARIPQQAGPGEGGAHPAHDTVRMPPPRPRNPHEGGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N689</accession>
    <name>A0A0F7N689_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_20235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017414.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_20235"/>
    <dbReference type="EnsemblBacteria" id="AKH84125">
        <property type="protein sequence ID" value="AKH84125"/>
        <property type="gene ID" value="AA958_20235"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_20235"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4261"/>
    <dbReference type="OrthoDB" id="1119700at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
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            <begin position="29"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AKH84125.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="277" mass="30518" checksum="767D38E82A147917" modified="2015-07-22" version="1">MSDWQLTRTFPSAAGEVRWDRLGAAGGRPVVLLHGTPWSSYTWRAVARALARGREVYVWDMPGYGQSEKRAGQDVSLDAQGRIFVQLLDHWRLDEPLVVAHDFGGAVALRAHLLHGATYRALALVDPVALAPWGSPFFRLVRDNAPVFEQLPAALHTALVREYITTTGGPGLHPVVLDALVAPWTDDAGRPAFYRQIAQADQRYTDEIQPRYGEIDLPALICWGTDDTWIPVAKAHELHALVPHAGLELFEGAGHLVQEDAPAELTAVLQTFLTEQS</sequence>
</entry>
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    <accession>A0A0F7N6C6</accession>
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    </gene>
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        <name type="scientific">Streptomyces sp. CNQ-509</name>
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        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">CNQ-509</strain>
        </source>
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            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH82909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="204" mass="20776" checksum="B26A2B5D9726405F" modified="2015-07-22" version="1">MSLRKNPLLTLALVAAALAAVLAAWAGTSWYAAAHDDAADFAASRDDALAAARQAVTNLNTLDHRDLDEGLDRWEASATGELLTQLRQGRAGFEKEVAKAETVTTAEVLSAALTELDDRAGRADVLVAVRITVAAPGEKPQAKESRMLGEVTRTGDGWKLSALGQAPAGDSAGGDAGEGSGRGPGQGTDQGPGSDSGRAGEAGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6K5</accession>
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        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7 8">CNQ-509</strain>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AKH82427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="85" mass="8933" checksum="E308C275D529024A" modified="2015-07-22" version="1">MAHKKGASSTRNGRDSNAQRLGVKRFGGQVVGAGEIIIRQRGTKFHPGTGVGRGGDDTLFALIPGSVQFGTSRGRKVVNIVQDAE</sequence>
</entry>
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                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
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    </dbReference>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
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    </gene>
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        <lineage>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
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    <dbReference type="EnsemblBacteria" id="AKH82507">
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        <property type="gene ID" value="AA958_09995"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_09995"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42698">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin_N" evidence="2">
        <location>
            <begin position="65"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH82507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="630" mass="65930" checksum="BF32B200B74DE0AC" modified="2015-07-22" version="1">MATSDVRPDLLNALSTLRECVAAARFPLPLPGADGARRSRAELLAQLDDYLVPRLHRPDAPLLAVVGGSTGAGKSTLVNSLVGRCVSESGVLRPTTRMPVLVCHPDDQSWFAGQRVLPHLTRVWMPRQDGAHGRVEAYESYGAYEAQEVDEPYGDGGDAGDGGGARQSFGGGGSRAAYGGSPREAYGANRGASGAYDVRDPYPPRHGPARDVLTPDGLTRRGLARGAATFGEGGGGPDGTLLRIEVDENVPSGLALLDAPDIDSLAGHARELAAELVCAADVWVLVTTASRYADAVPWHLLRTAKEYDVSLVTVLDRVPHQVAGEISLQYATLLRKAGLGDVPRFTVPELPESAGGGSGLLPATAVRELREWLAHRAQDPAARAEAAVRTANGVLASLRSRVTSLAGACAAQHAASSRMAHRVERSYEEAAEQAHADLVGGAAFAGDALAHYRNRALTGASGALLDALTGSVAAVLYCAVAAADERFTAELRREPGAAAVPFGEAGEGAQERVGVLVRRWQRCLEELADEALRAAERPGDADPEEVAALLAVALLGGANGQGAADELAALLGAKDGLRLRSRGGGLLGMYFERVLDGERDRRLAVIDALEAQSGQQAQLIAAMSVLQREK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6W7</accession>
    <name>A0A0F7N6W7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">NDP-hexose 4-ketoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AA958_18270</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017130.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_18270"/>
    <dbReference type="EnsemblBacteria" id="AKH83831">
        <property type="protein sequence ID" value="AKH83831"/>
        <property type="gene ID" value="AA958_18270"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_18270"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3840"/>
    <dbReference type="OrthoDB" id="44062at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001943">
        <property type="entry name" value="UVR_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
        <property type="entry name" value="SSF81923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51903">
        <property type="entry name" value="CLP_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Clp R" evidence="8">
        <location>
            <begin position="2"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="UVR" evidence="7">
        <location>
            <begin position="422"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="816"/>
            <end position="842"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH83831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="842" mass="93019" checksum="4A9A03D96DF51B6F" modified="2015-07-22" version="1">MFERFTDRARRVVVLAQEEARMLNHNYIGTEHILLGLIHEGEGVAAKALESLGISLEAVRQQVEEIIGQGQQAPSGHIPFTPRAKKVLELSLREALQLGHNYIGTEHILLGLIREGEGVAAQVLVKLGADLNRVRQQVIQLLSGYQGGKETATAGGPAEGTPSTSLVLDQFGRNLTQAARESKLDPVIGREKEIERVMQVLSRRTKNNPVLIGEPGVGKTAVVEGLAQAIVKGEVPETLKDKHLYTLDLGALVAGSRYRGDFEERLKKVLKEIRTRGDIILFIDELHTLVGAGAAEGAIDAASILKPMLARGELQTIGATTLDEYRKHLEKDAALERRFQPIQVAEPSLQHTIEILKGLRDRYEAHHRVSITDAALVAAAQLADRYISDRFLPDKAIDLIDEAGSRMRIRRMTAPPDLREFDEKIADVRREKESAIDSQDFELAAGLRDKEKQLLAQKAQREKEWKAGDMDVVAEVDEELIAEVLATATGIPVFKLTEEESSRLLRMEDELHKRVIGQEDAIKALSQAIRRTRAGLKDPKRPGGSFIFAGPSGVGKTELSKTLAEFLFGDEDALIQLDMSEFSEKHTVSRLFGSPPGYVGYEEGGQLTEKVRRKPFSVVLFDEVEKAHPDIFNSLLQILEDGRLTDSQGRVVDFKNTIIIMTTNLGTKDISKGFGLGFAAGGDVKSGYERMKSKVSEELKQHFRPEFLNRVDDIVVFHQLTRDDIIEIVDLRLAELDNRLKDRDMAIELSTEAKDLLSKRGFDPVLGARPLRRAIQREIEDVLSEKILFGELRPGHIVVVDTEGEGDDATFTFRGEEKSALPDAPPVDAAAGGAGPNLSKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6X6</accession>
    <name>A0A0F7N6X6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AA958_13795</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016458.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH83129">
        <property type="protein sequence ID" value="AKH83129"/>
        <property type="gene ID" value="AA958_13795"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_13795"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2905"/>
    <dbReference type="OrthoDB" id="1891092at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="158"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="9">
        <location>
            <begin position="29"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AKH83129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="279" mass="29455" checksum="258BC90D499ECEFA" modified="2015-07-22" version="1">MTATTPLAVPPPARTAGARLKWAVADGLTMTGRGLAHWARRPALVAVNLAFPVMMLVVFTYLLGGGMAVGGGGSYREYLVPGMFALSMSFGLEATMVSLTSDLGKGVVDRFRTMPMAPSAVLVGRALTDMAESAAGLAVMAGAGLAVGWRWHGTWAEALAAFGLLLLLRFAMLWAGIFLGLVAGKPEMVQAVQILVWPVAFLSSAFTSPETMPGWLGAVAEWNPMSATAGAIRELFGNPGWTGDSWAAQHPVLLAVVWPLVLLAVFFPLAVRRYRGLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6Z1</accession>
    <name>A0A0F7N6Z1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_13960</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016486.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_13960"/>
    <dbReference type="EnsemblBacteria" id="AKH83158">
        <property type="protein sequence ID" value="AKH83158"/>
        <property type="gene ID" value="AA958_13960"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_13960"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2938"/>
    <dbReference type="OrthoDB" id="1826886at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
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        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
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        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="7"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH83158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="188" mass="20420" checksum="1A1911BCC4C53213" modified="2015-07-22" version="1">MTAPPKPPARGRVLDAATRLFYAEGVHAVGVDRIIAEAGVAKATFYHHFRTKDDLVAAYVTDQCRRQQEAAAALAGTAPRATVLAVYDFIGEAGAGPGYRGCPFINAAAEYPDPDHPVRRAVTDYRRWFRDLMRDLLAADGHPDAERTADLLLVLRDGLVVGNDLDDAAALRKLTRDAVERVLTPRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6Z4</accession>
    <name>A0A0F7N6Z4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_10650</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015948.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH82607">
        <property type="protein sequence ID" value="AKH82607"/>
        <property type="gene ID" value="AA958_10650"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_10650"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2240"/>
    <dbReference type="OrthoDB" id="1990300at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000390">
        <property type="entry name" value="Small_drug/metabolite_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045324">
        <property type="entry name" value="Small_multidrug_res"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30561">
        <property type="entry name" value="PTHR30561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00893">
        <property type="entry name" value="Multi_Drug_Res"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH82607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="106" mass="10857" checksum="0102861D5BCA2AC0" modified="2015-07-22" version="1">MAWILLLAAGLLEVGWAIGMKYTEGFTRLWPSVFTIAGIAASMMLLAQAAKTLPIGTAYGVWVGIGAGGAALLGMVVLGEPATVARVFFVALLLVAVVGLRATSGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7J1</accession>
    <name>A0A0F7N7J1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Membrane protease subunits stomatin/prohibitin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_15230</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016657.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_15230"/>
    <dbReference type="EnsemblBacteria" id="AKH83343">
        <property type="protein sequence ID" value="AKH83343"/>
        <property type="gene ID" value="AA958_15230"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_15230"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3208"/>
    <dbReference type="OrthoDB" id="491786at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="SSF117892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="79"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="PHB" evidence="4">
        <location>
            <begin position="105"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="423"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="306"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH83343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="451" mass="49597" checksum="4718CF07BD928891" modified="2015-07-22" version="1">MSTAAMKRRSVISELVAAWGDIPQLLRGGEAGTLIPVIIPRHRRRLWWMVPLWLALLALATGVMAGLQSGSEDGWSASAYDALAAAAYGTGVFLLVVGVLWWWRSSIVKIEQGTNGVLTRYGAISRTLGPGRHFVWHPWSRVDFVVDTATEIPYSAPVMACPTQENVPLRSIDFFLKFRINDAVLFVRTIGAGNFDLVLSSAVQDAIRQRARRVRTERAYDLRGSDVADMQDLLNRQLARYGVRITGANIPDVQLPAQYQQHLATRERVAKERTAYEQEWGLIRKRRIDNLQMDIERAKKARDARFVEVKAALNRAREEVARLLEQQETEAQKVRFEIETRGRSGLIAAENEAKAQRRLAQAYRDNRAVLQYELARRRLEVGAVLAGSAPRPTVIRTDGGGGGGADGSALSTLLTAQLLPRLTAGSPAGDPPPAGGLLRAVAADGHGAGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7J7</accession>
    <name>A0A0F7N7J7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SUKH-3 domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_11980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016167.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_11980"/>
    <dbReference type="EnsemblBacteria" id="AKH82832">
        <property type="protein sequence ID" value="AKH82832"/>
        <property type="gene ID" value="AA958_11980"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_11980"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2521"/>
    <dbReference type="OrthoDB" id="1648755at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025850">
        <property type="entry name" value="SUKH-3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14433">
        <property type="entry name" value="SUKH-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH82832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="176" mass="18794" checksum="6C4F9215320CE18C" modified="2015-07-22" version="1">MVPSDPRDLAAHHTRFPVEVDSALRAAGWEPGRWDIRQAETWADTLRAHVSSGGHVHAVFPAAVEAWAEFGGLRVVGEGPGRQLGPADLHVDPMHGLHLTRTLADLGRALRTELCPLGAELAPDGSTAQAVLAVDAEGRGYALDHAGDWFLGRSVDEALVTLVTGLEPQRLTPEPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7S7</accession>
    <name>A0A0F7N7S7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_12060</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016182.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_12060"/>
    <dbReference type="EnsemblBacteria" id="AKH82847">
        <property type="protein sequence ID" value="AKH82847"/>
        <property type="gene ID" value="AA958_12060"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_12060"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2537"/>
    <dbReference type="OrthoDB" id="1687028at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="4"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="149"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH82847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="231" mass="23953" checksum="9B3F7469D10FF545" modified="2015-07-22" version="1">MAVRLIVVDEHRLLAEALASALKLRGHRVLAAAAPAAGAAELVVSRGPEVCLLGTATPAAPGAFDPVLRIKRERPQIAVVVLGPVPNPRGIAAAFAAGASGYVRHDERIEGVERALVKARAGEAAVAPQLLQSAFTELLNPAAEPDDEGARLLQLLTPREVEVLVRVAEGEDTRLIAQGMRIAASTARTHVQRVLMKLGVGSRLEAAALAARTGLLDRAAARPAVDGEAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7Z4</accession>
    <name>A0A0F7N7Z4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AsnC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_16450</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016839.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_16450"/>
    <dbReference type="EnsemblBacteria" id="AKH83534">
        <property type="protein sequence ID" value="AKH83534"/>
        <property type="gene ID" value="AA958_16450"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_16450"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3462"/>
    <dbReference type="OrthoDB" id="1844486at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13404">
        <property type="entry name" value="HTH_AsnC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="5">
        <location>
            <begin position="30"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH83534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="176" mass="19413" checksum="EFE949359F687873" modified="2015-07-22" version="1">MAEEQLAGDTPDLPAPAPAVPAPRPPARRLDSVDREIVRILRADGRASVRSVAEQVHVSRANAYARINRLIDDGVIRGFAARIDQERAGQGTSAYITLKIVQNTWRTARRQLEQLPGAAHIALVGGDFDVLLLVHTEDNRALRELVLTRIQSIPEVLSTRTLLVFEETDVQNDLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N840</accession>
    <name>A0A0F7N840_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Methionine--tRNA ligase</fullName>
            <ecNumber evidence="7">6.1.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Methionyl-tRNA synthetase</fullName>
            <shortName evidence="7">MetRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">metG</name>
        <name evidence="11" type="ORF">AA958_16705</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met)</text>
            <dbReference type="Rhea" id="RHEA:13481"/>
            <dbReference type="Rhea" id="RHEA-COMP:9667"/>
            <dbReference type="Rhea" id="RHEA-COMP:9698"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 2A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.10" evidence="7"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016884.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_16705"/>
    <dbReference type="EnsemblBacteria" id="AKH83579">
        <property type="protein sequence ID" value="AKH83579"/>
        <property type="gene ID" value="AA958_16705"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_16705"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3514"/>
    <dbReference type="OrthoDB" id="761140at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004825">
        <property type="term" value="F:methionine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006431">
        <property type="term" value="P:methionyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07957">
        <property type="entry name" value="Anticodon_Ia_Met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00814">
        <property type="entry name" value="MetRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01228">
        <property type="entry name" value="Met_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041872">
        <property type="entry name" value="Anticodon_Met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014758">
        <property type="entry name" value="Met-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023457">
        <property type="entry name" value="Met-tRNA_synth_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033911">
        <property type="entry name" value="MetRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43326">
        <property type="entry name" value="PTHR43326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19303">
        <property type="entry name" value="Anticodon_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01041">
        <property type="entry name" value="TRNASYNTHMET"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00398">
        <property type="entry name" value="metG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA-synt_1g" evidence="9">
        <location>
            <begin position="14"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-synt_1g" evidence="9">
        <location>
            <begin position="162"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_3" evidence="10">
        <location>
            <begin position="389"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="7">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="7">
        <location>
            <begin position="313"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF19303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AKH83579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="538" mass="60177" checksum="D1770128C4E3222C" modified="2015-07-22" version="1">MAATGEEQQGTKAYYVSTPIYYVNDAPHLGHAYTTVAGDVLTRWHRQRGEKVWYLTGTDEHGQKIMRTAEAHGVTPQEWCDKLVEEAWKPLWEHLEIANDDFIRTTEKRHTDRVQEFVQDLYDKGEIYQGGYEGPYCVGCEEYKTPGELLDGEGEYAGLKLCPIHKTPVEMLKEENYFFKLSEYGPKLLEFYEANPGFVQPESARNEVVNFVRQGLNDLSISRSTFDWGVRVPWDDKHVIYVWIDALLNYATAVGYGADEQKFAGTWPADVHLVGKDILRFHAVIWPAMLMANGLPLPGKVFANGWLMVGGEKMSKSNLTGIKPQDLTDHFGVDAYRWYFLRAIQYGQDGSFSWEDFTHRYTSELANDYGNLASRVGAMTVKYFDGDLPAAPAAGPAEQVIVDGLAHAAAEADRRIGDELDFAGGIAAVFDFIKKVNLYLTEQEPWKVAKDTSPEAQARLATILYTAAEALRAVAVLLHPVMPRTSQQLWSSLGAEPALGPLADQRLAEAADWGRLPAGARVTKGAILFPRLEEPKQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8A3</accession>
    <name>A0A0F7N8A3_9ACTN</name>
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            <fullName evidence="3">MerR family transcriptional regulator</fullName>
        </submittedName>
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        <name evidence="3" type="ORF">AA958_17170</name>
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    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
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        <lineage>
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            <taxon>Actinobacteria</taxon>
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        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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    </dbReference>
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH83654">
        <property type="protein sequence ID" value="AKH83654"/>
        <property type="gene ID" value="AA958_17170"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_17170"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3610"/>
    <dbReference type="OrthoDB" id="1748559at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH83654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="141" mass="15781" checksum="3DBDB87923754161" modified="2015-07-22" version="1">MRIGELSRLTGASRRLLRYYEEQGLIVPDRGANGYREYDDRYVDRVNQIRGLLDAGLPTRIIKQILPCLDKPRSIHFPDATPEMLALLAAERDRLTERIDVLIRNRDAMSEYLTEVAQCRAAAPGSSHGTPNSPSVVSATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8P6</accession>
    <name>A0A0F7N8P6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_13675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH83107">
        <property type="protein sequence ID" value="AKH83107"/>
        <property type="gene ID" value="AA958_13675"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_13675"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2878"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="33" mass="3580" checksum="C0C06AF6CF6BB24B" modified="2015-07-22" version="1">MLVVTFDILLALVCVGTLAFAGLVVKKLYQGQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8S6</accession>
    <name>A0A0F7N8S6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Galactose oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_25035</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84930.1"/>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_25035"/>
    <dbReference type="EnsemblBacteria" id="AKH84930">
        <property type="protein sequence ID" value="AKH84930"/>
        <property type="gene ID" value="AA958_25035"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_25035"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5276"/>
    <dbReference type="OrthoDB" id="1977684at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd02851">
        <property type="entry name" value="E_set_GO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037293">
        <property type="entry name" value="Gal_Oxidase_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015202">
        <property type="entry name" value="GO-like_E_set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09118">
        <property type="entry name" value="DUF1929"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="SSF50965"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519316" evidence="2">
        <location>
            <begin position="30"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1929" evidence="3">
        <location>
            <begin position="561"/>
            <end position="642"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH84930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="643" mass="69915" checksum="BAB13568B0D1C116" modified="2015-07-22" version="1">MGYRPGKRFKKAAMGTGVVMVLAALNAPAAIGFAEEQYHEYRISRPGYQRQYGSWQVQDTPDSYHLNAIHATLLHTGKVLLIAGSGNDQKQFDAGTFRTVLWDPEKNSYEEIRTPADLFCAGHTQLADGRLLVAGGTARYELLDGDVERAGGRMLVKNENPDKPVRLKKGTGFIAPSGLVYRTTAAVTVPAAEKKTAKRGKTVVTAAEANVFVEAEEEGRGYVQDRQAQYAVEGLTGKQADNVYGLAQKLTMDKQDFQGIKDTFEFDPVRERYVRVDPMDKARWYPTLVTLPDGKVLSVSGLDEAGEILYGDNEVYDPETKKWSKAPNRYFPTYPALFLTAGGKLFYSGANAGYGPADRGRKPGIWDLKDNSFTTVPGMTDPDQLETAGSLLLPPAQDQKVMVLGGGGVGESAKSTPRTSIIDLTEDRPAYADGPDLPQGTRYLNSVILPDDTVFTSGGSADYRGRGDSDIHKAQFYDPGTNSFTRAADPEVGRNYHSEAVLLPDGRVATFGSDPLFGDKANTRPGTFEKRIEIFTPPYLYKAEEGERLSIGAGPGRPGRGQQATYEVEGAGRVAKARLIRPGSVTHVTDVEQRSVQLDVKKSAGKVTVTVPADPSLVPPGWYMLFVTDGKGVPSEAKWVHVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8X0</accession>
    <name>A0A0F7N8X0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_25315</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018231.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_25315"/>
    <dbReference type="EnsemblBacteria" id="AKH84980">
        <property type="protein sequence ID" value="AKH84980"/>
        <property type="gene ID" value="AA958_25315"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_25315"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5335"/>
    <dbReference type="OrthoDB" id="1533093at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH84980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="356" mass="38086" checksum="34960EDE124F9EF0" modified="2015-07-22" version="1">MHGRPSGAPADAPVPPAPGVELFCDESGYEGENLVGGITDVFAHAGVTVPAADAAECIRELRDRIRSPATVYKANHLQREKHRGTLLWFLGPGGPLPGRARVHLTEKSFFAVARIVDLLVSGTDPADAAAMLRGAHARGPAGELYRAGPRLYGGERWRAFLAAFNELMWINTRRGAETSADGFFGLAGELHRAGAPGEAGRLLGLVRQARPRTEALRAALLEDPRTVPALDSLLPALAAAVAYWGRDGAPVTVVHDRQTAFTDERVARLYEVCRPPRAHLRGLRFVDAETDPRVQLADFLAGIARKRASDALAGLADPELDELLRPYVAPDSAWGDARSWALLGPEPAPRAGLAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N917</accession>
    <name>A0A0F7N917_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-lactamase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_14475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016552.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_14475"/>
    <dbReference type="EnsemblBacteria" id="AKH83237">
        <property type="protein sequence ID" value="AKH83237"/>
        <property type="gene ID" value="AA958_14475"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_14475"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3047"/>
    <dbReference type="OrthoDB" id="733552at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041516">
        <property type="entry name" value="LACTB2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17778">
        <property type="entry name" value="BLACT_WH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="39"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="277" mass="28860" checksum="A6D27D2C618DCB23" modified="2015-07-22" version="1">MTDAVALPGQPRGGVLSGPATARATCVLAPNASPMTLDGTNTWIVAEPDSARAVVIDPGPLDEGHLAAVVDTADRAGLRVALTLLTHGHADHAEGAARFAELTGTKVRALDPALRLGDEGLAAGDMISVGGLELRVVPTPGHTADSLCFHLPADDAVLTGDTVLGRGTTMVAHPDGRLGDYLDSLRRLRSLTVDDGVSTVLPGHGPVLEDAQGAVEFYLAHRATRLAQVETAVENGHRTAAEVVAHVYADVDRTLWPAAELSVRAQLEYLKEHGLIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N958</accession>
    <name>A0A0F7N958_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_19810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017343.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_19810"/>
    <dbReference type="EnsemblBacteria" id="AKH84053">
        <property type="protein sequence ID" value="AKH84053"/>
        <property type="gene ID" value="AA958_19810"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_19810"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4174"/>
    <dbReference type="OrthoDB" id="1865110at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH84053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="123" mass="13265" checksum="650B161650FCB47C" modified="2015-07-22" version="1">MEHQGLEQALHRARALILADLSAADVAGPDVVTFVEDAVVHRRWWVEQWPEGVAYLDGLVAQDVQDALLEKYGRWPLCPVCEDVDSTGPHALDIEPALGPDPRWVCGRTGAVMARVGSLGGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9D8</accession>
    <name>A0A0F7N9D8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH araC/xylS-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_20305</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017427.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_20305"/>
    <dbReference type="EnsemblBacteria" id="AKH84138">
        <property type="protein sequence ID" value="AKH84138"/>
        <property type="gene ID" value="AA958_20305"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_20305"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4276"/>
    <dbReference type="OrthoDB" id="1757088at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="165"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH84138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="269" mass="28742" checksum="1F87275780028AB7" modified="2015-07-22" version="1">MTGSGFDDAHGVLHPGEHARLASLNRRRPGAALAPFVDWFWHVRWQLPGAATYDTKVLTHPNLHLVFEEPEPLVYGVQRDLFVRRLAGGGQVLGVRFRPGGFRALTTGPVAELADRRVPAAELLGPEAAEVSRAVLAAEDLADMCAVAEDFLRPLLPAAPDPAAEEAAAVVARITAEPGLLRVDQVAAGARMSVRRLQRLFAEYVGASPKWVLRRARLQEAAARADAGAALDLAALAADLGYADQAHLTRDFTATVGAPPSRYAEGTPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-10-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9L8</accession>
    <name>A0A0F7N9L8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_20280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH84134">
        <property type="protein sequence ID" value="AKH84134"/>
        <property type="gene ID" value="AA958_20280"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_20280"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4270"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="106" mass="10431" checksum="4A09507BDE040F20" modified="2015-07-22" version="1">MITLLEPETTTAAATMKGGPGAGNRRPATAKGGGPVTGSRRTVRVPATAKGGIGVGTRRTERVRATAKTGGGGIGSRRSVRVPASVKGGSGVGSRRRRVPAGGGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9U7</accession>
    <name>A0A0F7N9U7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ArsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_20850</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017519.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_20850"/>
    <dbReference type="EnsemblBacteria" id="AKH84234">
        <property type="protein sequence ID" value="AKH84234"/>
        <property type="gene ID" value="AA958_20850"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_20850"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4395"/>
    <dbReference type="OrthoDB" id="1617768at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="2">
        <location>
            <begin position="2"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH84234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="141" mass="15587" checksum="8D13DE829C933FEE" modified="2015-07-22" version="1">MPATQDTRGEDRVFGALSSPVRREVLRLLRDEGPQPVQQLAAHFDMRRPSLSEHLKVLREAGLVSEERAGRQRIYRLEAEPLTEVRDWLGPYERFWRAKLADLAELLDDLPEADGDGGRDRDRADGADRAGGPGAGTGSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9V6</accession>
    <name>A0A0F7N9V6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpsR</name>
        <name evidence="6" type="ORF">AA958_16070</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein S6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the bacterial ribosomal protein bS18 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_S18"/>
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        <property type="entry name" value="Ribosomal_S18_CS"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01084">
        <property type="entry name" value="Ribosomal_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH83472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="78" mass="9012" checksum="AA1ABBBDD012FB13" modified="2015-07-22" version="1">MAKPPPRKPKKKVCVFCKEKISYVDYKDTNLLRKFISDRGKIRARRVTGNCTQHQRDVATAVKNSREMALLPYTSTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9Y0</accession>
    <name>A0A0F7N9Y0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_21165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AKH84284">
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        <property type="gene ID" value="AA958_21165"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_21165"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4458"/>
    <dbReference type="OrthoDB" id="1832160at2"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
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        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HATPase_c" evidence="1">
        <location>
            <begin position="25"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="161" mass="17029" checksum="8E95F53B8AEEE8F5" modified="2015-07-22" version="1">MPPHLPAPAPTPTPPIPPLPVRRTFPAHPLSVPRARRAVLDALPRPHHPRLRDDLQLLVSELVTNAVRHGAQPAGDHLVELLLWPADGHYWLAVSDPGPGLPALSPAPPDAADTACGGRGLLLVDALAAAWGVVPRRVRGKAVVAGLPFPAPDYGRARDGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NA15</accession>
    <name>A0A0F7NA15_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_24670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018123.1">
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_24670"/>
    <dbReference type="EnsemblBacteria" id="AKH84871">
        <property type="protein sequence ID" value="AKH84871"/>
        <property type="gene ID" value="AA958_24670"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_24670"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5203"/>
    <dbReference type="OrthoDB" id="2059359at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="218" mass="21623" checksum="0D1FDF8088D7767A" modified="2015-07-22" version="1">MGAFVDAALGFPAVVFSFALLVVIAYWLFAAVTGLVGDAVGADGDMAAAGRGAGGFTVLPAALGLGGVPVTVVLSLVVAVAWFTALAAGVAVGAAGPPVWLDWPARTAGLVLALAAGWYATWLLARPLRRLGGTGRPVGRRDFVGRTCVVRTSGVTPAYGQAEVTAADGSSATVQVRADAGNGLAAGSRALIFAYDAEGEFFRVAPADGVPGASGSFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NA33</accession>
    <name>A0A0F7NA33_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Glycerol-3-phosphate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AA958_21540</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017615.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_21540"/>
    <dbReference type="EnsemblBacteria" id="AKH84353">
        <property type="protein sequence ID" value="AKH84353"/>
        <property type="gene ID" value="AA958_21540"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_21540"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4536"/>
    <dbReference type="OrthoDB" id="360065at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009331">
        <property type="term" value="C:glycerol-3-phosphate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004368">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006072">
        <property type="term" value="P:glycerol-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.870">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031656">
        <property type="entry name" value="DAO_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038299">
        <property type="entry name" value="DAO_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000447">
        <property type="entry name" value="G3P_DH_FAD-dep"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11985">
        <property type="entry name" value="PTHR11985"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16901">
        <property type="entry name" value="DAO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01001">
        <property type="entry name" value="FADG3PDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="7">
        <location>
            <begin position="24"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="DAO_C" evidence="8">
        <location>
            <begin position="404"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="538"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="538"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH84353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="568" mass="61867" checksum="30CF210EA41AABBE" modified="2015-07-22" version="1">MKTAVLGPAERGAALAQMAERELDLLVVGAGVVGAGTALDAATRGLATGLVEARDWASGTSSRSSKLIHGGLRYLEMLDFALVREALKERGLLTERLAPHLVKPVPFLYPLKHRAWERAYAGSGVLLYDAMSVARAHGRGMPAHRHLSRSHALRVAPCLRKDALVGALQYYDAQVDDARYVATLVRTAAQYGAQVANRARVVGFLREGERVVGARVHDLEQGGEFEVRARQVVNATGVWTDETQAMVGERGQFHVRASKGIHLVVPKDRIHSTSGLLLRTEKSVLFVIPWGRHWIIGTTDTDWDLDKAHPAASSADIDYLLEHVNAVLAVPLTRDDVEGVYAGLRPLLAGESDATSKLSREHTVAHPVPGLVVVAGGKYTTYRVMAKDAVDEAVHGLDQRVGPCVTEDVRLLGAEGYQALWNARARTAARTGVHVARVEHLLNRYGSLSEEVLELIERDPSLGLPLTGADDYLRAEVVYAASHEGARHLDDVLTRRTRISIETFDRGTQCAAEVAALMAPVLGWDGDQVEREVAHYDKRVEAERESQRQPDDQTADAARLGAPEIVPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAD3</accession>
    <name>A0A0F7NAD3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit C</fullName>
            <shortName evidence="1">Asp/Glu-ADT subunit C</shortName>
            <ecNumber evidence="1">6.3.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">gatC</name>
        <name evidence="3" type="ORF">AA958_25480</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + L-aspartyl-tRNA(Asn) + L-glutamine = ADP + 2 H(+) + L-asparaginyl-tRNA(Asn) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14513"/>
            <dbReference type="Rhea" id="RHEA-COMP:9674"/>
            <dbReference type="Rhea" id="RHEA-COMP:9677"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78515"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterotrimer of A, B and C subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GatC family.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.-" evidence="1"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018262.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_25480"/>
    <dbReference type="EnsemblBacteria" id="AKH85011">
        <property type="protein sequence ID" value="AKH85011"/>
        <property type="gene ID" value="AA958_25480"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_25480"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5370"/>
    <dbReference type="OrthoDB" id="1780195at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050566">
        <property type="term" value="F:asparaginyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00122">
        <property type="entry name" value="GatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003837">
        <property type="entry name" value="Asp/Glu-ADT_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036113">
        <property type="entry name" value="Asp/Glu-ADT_sf_sub_c"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02686">
        <property type="entry name" value="Glu-tRNAGln"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141000">
        <property type="entry name" value="SSF141000"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00135">
        <property type="entry name" value="gatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH85011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="98" mass="10532" checksum="4CE9C01700B814E9" modified="2015-07-22" version="1">MPGITREEVAHLARLARLELSGEELDHFAGQLDAIIGAVARVADVAGEDVPPTSHPLPLTNVMRPDTVRPSFTAQQALSGAPAQEQQRFKVPQILGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAE3</accession>
    <name>A0A0F7NAE3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glucose sorbosone dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_25535</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018272.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_25535"/>
    <dbReference type="EnsemblBacteria" id="AKH85021">
        <property type="protein sequence ID" value="AKH85021"/>
        <property type="gene ID" value="AA958_25535"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_25535"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5383"/>
    <dbReference type="OrthoDB" id="567019at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012938">
        <property type="entry name" value="Glc/Sorbosone_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011041">
        <property type="entry name" value="Quinoprot_gluc/sorb_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07995">
        <property type="entry name" value="GSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50952">
        <property type="entry name" value="SSF50952"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519432" evidence="2">
        <location>
            <begin position="24"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="GSDH" evidence="3">
        <location>
            <begin position="68"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH85021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="382" mass="39911" checksum="BDD1B579D6DA9C4E" modified="2015-07-22" version="1">MRARAFTAVAAAALVLAAGCSSGDDDGAGGKDASSSTAPAGSGGATDGGEPPPAKGSAKVVGTVAENLETPWGLAELPGGDLLVSSRDTGTVYHVAAGGGKVTEAGEVPGVQREPGNEGGLLGLALGADEMLYAYFTSDSDNRIVRMTYDSDGAEGNRLGAPDTVFRGIPKGGRHNGGRIAFGPDKMLYVGTGEAGDPALAQDMDSLGGKILRMTPDGEPARGNPEAGSVVYSYGHRNVQGLAWDDDKRLWAAEFGDQKWDELNLIEPGKNYGWPEVEGKENRDGFVDPVVQWPTPDASPSGIAFADGSIWMASLRGERLWRIPLDGTKAAADPQAFFDGTYGRLRTVQRASDGDLLLMTNETDLRGTPEKGDDRILRLEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAJ6</accession>
    <name>A0A0F7NAJ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3-hydroxybutyryl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_28655</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018789.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_28655"/>
    <dbReference type="EnsemblBacteria" id="AKH85555">
        <property type="protein sequence ID" value="AKH85555"/>
        <property type="gene ID" value="AA958_28655"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_28655"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6037"/>
    <dbReference type="OrthoDB" id="862072at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3HCDH_N" evidence="2">
        <location>
            <begin position="19"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="3HCDH" evidence="1">
        <location>
            <begin position="200"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="3HCDH_N" evidence="2">
        <location>
            <begin position="325"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="3HCDH" evidence="1">
        <location>
            <begin position="505"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH85555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="606" mass="62633" checksum="FBA4816FFCC1295B" modified="2015-07-22" version="1">MDRSPVPESPEFPPVPFPTVAVVGLGTMGTGLCEVLARAGREVVGIDVSPAAARGCVAALERATERAVARGRLAEGDRAGVLARLRTFPGLRAAADADLVIEVVPESYEIKQQVIAELDGIVRPGTVLATGTNALSVTRLAASSARPERVLGLHFFTPVQAMRLVEVVSSVLTEPSAVAQVTALVRELGKEPVAVGDRPGFIADGLLFGYLNQAAAMYESRYATREDIDAAMKLGCGLPMGPLELLDLIGVDTARTVLEAMYAASQDRLHAPAPVLGQLTAAGFTGRKAGRGFYAYDAPGSGTVVPDAAPGAAAPGAPPRPVEEIGVAGSGTMASGIAEVCARAGYAVTLAARSTDKAAAARARVAASLDRSVARGRLDAAGRDAALARISPAGTLDALAGAGLVVEAVAEDLAVKRQVFAALDEVARPGAVLATTTSSLPVIACAAATSRPEDVVGMHFFNPAQAMKLVEVVRTVRTADDAHATVRAVCARLGKHAVDCGDRAGFIVNALLFPYLNNAVKMVQEHYASPDDIDAAMKLGGGYPMGPFELLDVVGLDVSLAIERVLHREFRDPGLAPAPLLEHLVAAGCLGRKTGRGFREYAAAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAU1</accession>
    <name>A0A0F7NAU1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptide ABC transporter ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_23215</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017885.1">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="23"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="67"/>
            <end position="74"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH84628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="378" mass="41428" checksum="0D9C46695D0ECC4E" modified="2015-07-22" version="1">MSEELTLPGPRDDTPTTAGEELLTAEGLTKHFPIMGGFPIKRRVGAVQAVDGIDLEVRAAESLGLVGESGCGKSTTGRLLTRLLEPTGGKITYRGQDITYAKRKQLAPIRSEIQMIFQDPYSSLNPRQTVGTIISSPMEVNGITPPGGREKRVRELLETVGLNPEHYNRFPHEFSGGQRQRIGVARALALKPKLIVADEPVSALDVSIQAQVVNLLQELQREMGIAFLFIAHDLAVVRHFSQRVAVMYLGKIVEIGPRDDIYTRPRHPYTHALLSAVPEATLSEDEDEKPRERIRLAGDVPSPINPPSGCRFRTRCWKAQDVCAEKEPPLVQIGGNNAGHLTACHFPEEPTVERDEVVILDKALAALEEGPSAAPVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAV8</accession>
    <name>A0A0F7NAV8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Branched-chain amino acid ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_29215</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
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        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP011492">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AKH85645">
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        <property type="gene ID" value="AA958_29215"/>
    </dbReference>
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    <dbReference type="PATRIC" id="fig|444103.5.peg.6159"/>
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    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="258"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH85645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="287" mass="28890" checksum="3475545F5E26C4F7" modified="2015-07-22" version="1">MSEFVQYLISGLAVGCGFALLGSGLVTIHRVTRVVNFAQGMFAVVAGLTAGSLLSAGLPHGVAEVVAVLAASGAGLLVGIAAIGRRGTSPQSALIVTLGIGFLAYAVEIMIWGEDPRSFPGLGGAVEIGGAYLQKQYFLVIGAAAVGFAALGLFFTRTHLGKALGACASNPYAARAVGIDVTRMGLVAFALGGALGGVAGVLITPLQSLSYDSDVLLITNGFAAAILGGLIRLGPALAGGLALGVAESMVAGYYKASYQSVVALALMLAVMIWRASQHTALHEEAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBA6</accession>
    <name>A0A0F7NBA6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Methyltransferase type 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AA958_27670</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNQ-509</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018620.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH85386">
        <property type="protein sequence ID" value="AKH85386"/>
        <property type="gene ID" value="AA958_27670"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_27670"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5829"/>
    <dbReference type="OrthoDB" id="957193at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024026">
        <property type="entry name" value="3'-RNA_MeTfrase_Hen1_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026610">
        <property type="entry name" value="Hen1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024740">
        <property type="entry name" value="Hen1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038546">
        <property type="entry name" value="Hen1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21404">
        <property type="entry name" value="PTHR21404"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12623">
        <property type="entry name" value="Hen1_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04074">
        <property type="entry name" value="bacter_Hen1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hen1_L" evidence="10">
        <location>
            <begin position="1"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransf_12" evidence="9">
        <location>
            <begin position="305"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="480"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="480"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AKH85386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="508" mass="55032" checksum="5FD4396B7BB8A75A" modified="2015-07-22" version="1">MFFTITATGTDAAPATDLGFLLHKHPGKAQEFATARGTAHVFYPEATPARCTAALLLEVDPVGLVRAAKGKDRGGKGKSPDSALAQYVNDRPYAASSLLAVALGRVFRTAMTGTSRTHPERAAQPLPLRIEVPAVPARGGPELVARLFAPMGWRVTADAVPLDPAFPEWGDSRYVSLVLDGEVRLADALRHLYVLLPVLDDAKHYGVAPDEVDKLLRAGEGWLEDHPEQRLITGRYLSRRWSLAREALERLELARLAESDDAEPEELDNAVDEATDTEEKPVPLAVQRRAAIAEALRAAGAARVLDLGCGQGQLVKELLNDPRFTEIVGVDVSVRALAAAARRLRLERMGERQAARVSLLQSALTYTDRRLAGYDAAVLSEVVEHVDPPRLPALEYAVFGSARPATVVVTTPNSEYNVRWESLPAGHVRHADHRFEWTRAEFRAWAEPVAARFGYAVAYEGVGQDDPEVGHPTQLAVFTRTAARSGTEPATGTTTGTTGPDHTPKEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBG4</accession>
    <name>A0A0F7NBG4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_28130</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018695.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_28130"/>
    <dbReference type="EnsemblBacteria" id="AKH85461">
        <property type="protein sequence ID" value="AKH85461"/>
        <property type="gene ID" value="AA958_28130"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_28130"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5928"/>
    <dbReference type="OrthoDB" id="916788at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="32"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="88"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH85461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="293" mass="31296" checksum="1CEC793DA6667878" modified="2015-07-22" version="1">MTTAQDDIKAPAAVPTAPERTGRRGARFGNQLAAFGSAVWRPLIVLAVIGLVWWFVTAREMVERYLVPTPGSVFEVMWEDRSMLAEHTYVTLYETVIGFLLAALIGIASAVLIVYSKTAERSLYPIILFAQVIPKIAIAPILIVWFGTGLSPKIILAVLIAFFPVVVSGVAGLRDTDPELLDLSATMGASRWSVFVKVRFPGALPQLMAGLKVAVTLAVVGAVVGEFVGASEGLGYILLLASGNLNSALLFADLILMSAIGVVLFVVIEVAESLLIPWHASRREGSSVTMATT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBG7</accession>
    <name>A0A0F7NBG7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methyltransf_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_24275</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018065.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_24275"/>
    <dbReference type="EnsemblBacteria" id="AKH84813">
        <property type="protein sequence ID" value="AKH84813"/>
        <property type="gene ID" value="AA958_24275"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_24275"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5115"/>
    <dbReference type="OrthoDB" id="1213908at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="O_MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005739">
        <property type="entry name" value="O-mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_2" evidence="3">
        <location>
            <begin position="113"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH84813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="344" mass="37630" checksum="A163B38563B9131B" modified="2015-07-22" version="1">MVGPTRFMTLLSCFELGIIDALRDKPGMTAADLGAAVGTKPDAVEQLLFLLIKEGFVARDEASGTYTLDALGEVPERDLKRALTYMNMIKVVALRQLFHLTESARTGTLVGLKEFYGVTEGTMYDAVAEHKDLRESWGTLMDNVTANIDPWFFGNVDIAAGAQVLDLAGNTGLGAIHAYESKASPGLRVTTFDLPEKEEEALENFRAHGVAEHCSFIGGNVFEEIPQGFDVVLIKHFLDMFDKDDVIRILTGVNRSLPVGGEVNVLVPVYPENLTDTDNYNVDFFPAFFIGCTMGQGGPQKLSVYRSWLEECGFEVTKAITKDPAELPKDVIPVPALLSATKVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NC04</accession>
    <name>A0A0F7NC04_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_31505</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019223.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH85995">
        <property type="protein sequence ID" value="AKH85995"/>
        <property type="gene ID" value="AA958_31505"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_31505"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6655"/>
    <dbReference type="OrthoDB" id="2101411at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH85995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="82" mass="8734" checksum="29870B998379F2CB" modified="2015-07-22" version="1">MSSRLGLGLGHERHPLLGKLVLDRASGRTGVLRAICPEPETHTVWSAPVLRQVAGPRMAWLVPVGGGVEWTTTPDAIEEATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDB0</accession>
    <name>A0A0F7NDB0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">1-deoxy-D-xylulose-5-phosphate synthase</fullName>
            <ecNumber evidence="10">2.2.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">1-deoxyxylulose-5-phosphate synthase</fullName>
            <shortName evidence="10">DXP synthase</shortName>
            <shortName evidence="10">DXPS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">dxs</name>
        <name evidence="13" type="ORF">AA958_27820</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>D-glyceraldehyde 3-phosphate + H(+) + pyruvate = 1-deoxy-D-xylulose 5-phosphate + CO2</text>
            <dbReference type="Rhea" id="RHEA:12605"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="10">Binds 1 thiamine pyrophosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Metabolic intermediate biosynthesis; 1-deoxy-D-xylulose 5-phosphate biosynthesis; 1-deoxy-D-xylulose 5-phosphate from D-glyceraldehyde 3-phosphate and pyruvate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 10">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the transketolase family. DXPS subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.7" evidence="10"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018643.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_27820"/>
    <dbReference type="EnsemblBacteria" id="AKH85409">
        <property type="protein sequence ID" value="AKH85409"/>
        <property type="gene ID" value="AA958_27820"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_27820"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5864"/>
    <dbReference type="OrthoDB" id="566385at2"/>
    <dbReference type="UniPathway" id="UPA00064">
        <property type="reaction ID" value="UER00091"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008661">
        <property type="term" value="F:1-deoxy-D-xylulose-5-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052865">
        <property type="term" value="P:1-deoxy-D-xylulose 5-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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        <location>
            <begin position="29"/>
            <end position="48"/>
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        <location>
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        <ligand>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
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        </source>
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        </source>
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        </source>
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        </source>
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        </source>
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        </source>
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        </source>
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            <dbReference type="PROSITE" id="PS00801"/>
        </source>
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        </source>
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        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="655" mass="69667" checksum="EDB1C0ACE57F5B4A" modified="2015-07-22" version="1">MAMLARIKGPRDLDRLGPEQLDRLAAEIRTFLVESVARTGGHLGPNLGVVELSIALHRVFESPRDRVLWDTGHQSYVHKLLTGRQDFGKLKKKGGLSGYPSRAESDHDVIENSHASTVLGWADGLAKANEVLGRDAAVVAVIGDGALTGGMAWEALNNIAAAQDRPLVIVVNDNERSYAPTIGGLADHLATLRTTDGYERFLARGKELLDRTPVVGKPLYETLHGAKKGLKDFIAPQGMFEDLGLKYVGPIDGHDIAAVESALQRARRFGGPVIVHCLTEKGRGYLPARQDEADQFHQVGVIHPDTGLPVAAGGADWTSVFADEMVRIGRERPDVVGITAAMMRPVGLQKFAETFPDRVYDVGIAEQHAAVSAAGLATGGLHPVFAVYATFLNRAFDQVLMDVALHRCGVTFVLDRAGVTGSDGASHNGMWDMSILQVVPGLRIAAPRDADQVRAQLREAVDVDDAPTVVRYSKGAVGPAVPAIGRTGGMDVLHEPAAGTEGAEHPDVLLVSIGALAPMCLEVAGLLDKQGITTTVVDPRWVKPVDAALPPLAERHRVVVTVEDNIRTGGVGSAVAQALRDAGVDMPLRDFGIPERFLDHASRQEVLADIGLTAPDIARQVTGLVARLDRRADDQADDLAAQGTGEGTVSKVAGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDH6</accession>
    <name>A0A0F7NDH6_9ACTN</name>
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        </submittedName>
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        <name evidence="8" type="ORF">AA958_33315</name>
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        <name type="scientific">Streptomyces sp. CNQ-509</name>
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            <taxon>Streptomycetaceae</taxon>
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        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
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        <text evidence="1">Belongs to the IMPDH/GMPR family.</text>
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    <dbReference type="EnsemblBacteria" id="AKH86296">
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    <dbReference type="PATRIC" id="fig|444103.5.peg.7036"/>
    <dbReference type="OrthoDB" id="532857at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="F:IMP dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Aldolase_TIM"/>
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    </dbReference>
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        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="IMP_DH-rel1"/>
    </dbReference>
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        <property type="entry name" value="IMP_DH_GMPRt"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    <keyword evidence="3 6" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="2 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0630">Potassium</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="7">
        <location>
            <begin position="95"/>
            <end position="151"/>
        </location>
    </feature>
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            <end position="211"/>
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        <location>
            <begin position="245"/>
            <end position="247"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
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        <location>
            <begin position="295"/>
            <end position="297"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
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        <location>
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        </ligand>
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        <location>
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        </location>
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            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR000130-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH86296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="479" mass="50517" checksum="C4FB3DD4CC79EB89" modified="2015-07-22" version="1">MRFLNDSPAPYDLTYDDVFMVPRRSGVGSRQAVDLSSADGTGTTIPLVVANMTAIAGRRMAETVARRGGLVVIPQDIPIDVVTEVVSWVKERDLVLDTPIVLGPHSTVADALALLPKRAHGAAVVVEDGRPVGVVTEADLNGVDRFTQLSEVMSRDLLTLDADIDPREAFNRLDAAHRRLAPAVGPDGRLVGLLTRKGALRATLYTPATDARGRLRIAAAVGINGDVAGRAEQLLDAGIDTLVVDTAHGHQEQMILALRAVRALGPEVPVAAGNIVAAEGVRDLVEAGADIVKVGVGPGAMCTTRMMTGVGRPQFSAVLECAAEARRLGKHVWADGGVRHPRDVAMALAAGASNVMIGSWFAGTYESPGDLQQTADGRLYKESFGMASARAVRGRTVEESAYDRARKGLFEEGISTSRMFLDPARPGVEDVIDAVVAGVRSACTYAGAATLEEFHERAVVGVQSAAGYAEGQPLHASWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDJ7</accession>
    <name>A0A0F7NDJ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD-dependent dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_24145</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018044.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_24145"/>
    <dbReference type="EnsemblBacteria" id="AKH84792">
        <property type="protein sequence ID" value="AKH84792"/>
        <property type="gene ID" value="AA958_24145"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_24145"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5088"/>
    <dbReference type="OrthoDB" id="1180629at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="2">
        <location>
            <begin position="10"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH84792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="278" mass="30045" checksum="FFCE39FC79818EA1" modified="2015-07-22" version="1">MSAHRPPRTVLLTGAAGGIGTLMRGLLPAHGHELRLLDRVAVDPGPERAVTADLADRGALREAVRGVDAVLHLAGISLESTFEKVLRANIEGTYHLYEAVREEGVRRVVFASSNHAVGFHPRPRRAGRVPAAELIGTDAAHRPDTFYGLSKCFGEDLAQLYWDKHGIETVSVRIGSCFPEPTSVRMLSLWLSPADGARLFHAALSAPDVGHTVVYGSSANTRAWWDLNTARALGYEPQDDSEVYADKLLAEQGPDAPDAPDRANLGGPFCTDPPIWPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDN8</accession>
    <name>A0A0F7NDN8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AA958_28625</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018783.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_28625"/>
    <dbReference type="EnsemblBacteria" id="AKH85549">
        <property type="protein sequence ID" value="AKH85549"/>
        <property type="gene ID" value="AA958_28625"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_28625"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6030"/>
    <dbReference type="OrthoDB" id="760677at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="11"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="126"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="249"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH85549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="405" mass="44186" checksum="60C4D13D36423EAE" modified="2015-07-22" version="1">MGRLAQTEGLTEVQREIVATVRGFVDKEILPVATGLEHRDEYPAQIVEGLKELGIFGLMIPEEYGGLGESLLTYALCVEEIARGWMSVSGIINTHFIVAYMIKQHGTREQREHFLPLMAAGEVRGAFSMSEPGLGSDVAAIKSKGVRDGESGDYLLTGQKMWLTNGGTSSLVAVLCRTDEGLGPEAPAHRSMTTFLVEKEPGFGTVKPGLTIPGKIDKMGYKGVDTTELIMDGLRVPADRVLGGPEGAGRGFYQMMDGVEVGRVNVAARGCGVAQRAFELGVGYAQQRHAFGRQIARHQAIQFKLAEMATKVEAAHAMMVRAARKKDTGERNDLEAGMAKYLASEYCKEVVEDAFRIHGGYGFSKEYEIERLYREAPMLLIGEGTAEIQKMIIGRRLLEEYGSQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDP9</accession>
    <name>A0A0F7NDP9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_28710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018798.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_28710"/>
    <dbReference type="EnsemblBacteria" id="AKH85564">
        <property type="protein sequence ID" value="AKH85564"/>
        <property type="gene ID" value="AA958_28710"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_28710"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6051"/>
    <dbReference type="OrthoDB" id="1501005at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="13"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="184" mass="20231" checksum="6CEECCF4E8311837" modified="2015-07-22" version="1">MPENDVIAAGARTAIRLPRPADEEEFLARARASARLHHPWLSPPATPADYRAYLERLTEPQTEGFLVCERESGALAGFVNINAIVRRAFLSGALGYAAFVPYAGRGLMSEGIGLVVRHAFTHLGLHRLEINVQPGNAASIALAKRAGFRLEGFSPDYLFIDGAWRDHERWALTVEMTDIDGPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NE87</accession>
    <name>A0A0F7NE87_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chaplin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_05070</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019792.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_05070"/>
    <dbReference type="EnsemblBacteria" id="AKH86556">
        <property type="protein sequence ID" value="AKH86556"/>
        <property type="gene ID" value="AA958_05070"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_05070"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1062"/>
    <dbReference type="OrthoDB" id="2037979at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005528">
        <property type="entry name" value="ChpA-H"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03777">
        <property type="entry name" value="ChpA-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51884">
        <property type="entry name" value="CHAPLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0034">Amyloid</keyword>
    <keyword evidence="2" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519549" evidence="5">
        <location>
            <begin position="28"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="Chaplin" evidence="6">
        <location>
            <begin position="40"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH86556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="81" mass="7561" checksum="BA1F647DBC03B289" modified="2015-07-22" version="1">MRNLKRAAALTIAAGGLAMAGAGMAAAHGGAAAGGQAVGSPGIGSGNLIQAPVHVPVNACGNTATVVGALNPAFGNLCLNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NEB9</accession>
    <name>A0A0F7NEB9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ion transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AA958_08145</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_08145"/>
    <dbReference type="EnsemblBacteria" id="AKH86606">
        <property type="protein sequence ID" value="AKH86606"/>
        <property type="gene ID" value="AA958_08145"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_08145"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1716"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005249">
        <property type="term" value="F:voltage-gated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028325">
        <property type="entry name" value="VG_K_chnl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537">
        <property type="entry name" value="PTHR11537"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0407">Ion channel</keyword>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="174"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Ion_trans_2" evidence="9">
        <location>
            <begin position="119"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="208"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AKH86606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="256" mass="27408" checksum="CC59BFA9EF9E190F" modified="2015-07-22" version="1">MARWERRTRRPLLGLALVFATAYAMPIVDPGMPGALHTACRAATWAVWAVFAADYAWRLRLAEDRWRFVRTHALDLCAVLLPLIRPLRLLQLVSALLLTGRLATAAAQVRLTTHVVGSVLVLWLFGALAVLEVERGEPGANIHTLGDAVWWAFTTMTTVGYGDLAPTTGLGRLLAIGLMVSGIALLGLVTANIAAWFISQVRQESEHEEKQTAALRELTREVASLRAEVTALRQAGVEAAAAPAGGAVPGPAAPGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NED2</accession>
    <name>A0A0F7NED2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">NADH dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_30465</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Membrane</location>
            <topology evidence="1 5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019052.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_30465"/>
    <dbReference type="EnsemblBacteria" id="AKH85824">
        <property type="protein sequence ID" value="AKH85824"/>
        <property type="gene ID" value="AA958_30465"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_30465"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6438"/>
    <dbReference type="OrthoDB" id="1274678at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003945">
        <property type="entry name" value="NU5C-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42829">
        <property type="entry name" value="PTHR42829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="30"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="265"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="322"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="356"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="394"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="445"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="489"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="610"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="7">
        <location>
            <begin position="122"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH85824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="632" mass="63149" checksum="C21D3EFF1D0D9D10" modified="2015-07-22" version="1">MSAALWALVALPLAAGTLLAAIGRRTDRFAPAVAVATSAAVLALAGYAAAVPAAVRAPLLAGLPFGLGAHGLSGPMAVTVAAVTLAVLVFSAGDIGAGQPRARFFGLMLLFGGAMLVTVTATTLPALLMGWEFMGATSWALIGFRWHDPAGAEAAGVAYVTTRAADLGLYLAAGAALAAGQASGLALDRLHEVPAPWLHLLTAGVVAAALGKSAQLPYSFWLSRAMRGPSPVSALLHSATMVVAGAYLLLRLQPLLAASGWGDDAVAWTGAATALALGLVAVAQRDLKQLLAASSCAQIGFMVLAAGASATTGGTLQLMAHAAAKSLAFLVAGFWLTAFGAGTLPALRGAARRNRIGGAAFTVAALSLAGVPPLSLWAAKDLLLAGALETSPALYAAGLAAAVVSAVYAVKALWYVWRPPGPVRLPVPAPAAAGRREGRPQGPRALPVPGAAAFAALALAVAALAVLALPGPRAAVADRIGAGGEAAPYAWELALSAALALAAAAAAWAWGDRRSPLPARVTAAASAWLGLEAGVRALLVRPVCRLAAALAAFDDRVLDRGVDGLARGTVWLAGGADRGAEAAVDGAVEGIGALSRALGRLARRPQTGQVHTYLAQAVAAFTVLAAVFVLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NEE8</accession>
    <name>A0A0F7NEE8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Xylan alpha-1,2-glucuronidase</fullName>
            <ecNumber evidence="7">3.2.1.131</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AA958_29895</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>Hydrolysis of (1-&gt;2)-alpha-D-(4-O-methyl)glucuronosyl links in the main chain of hardwood xylans.</text>
            <dbReference type="EC" id="3.2.1.131"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the glycosyl hydrolase 67 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.131" evidence="7"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018966.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_29895"/>
    <dbReference type="EnsemblBacteria" id="AKH85738">
        <property type="protein sequence ID" value="AKH85738"/>
        <property type="gene ID" value="AA958_29895"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_29895"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6313"/>
    <dbReference type="OrthoDB" id="11273at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046559">
        <property type="term" value="F:alpha-glucuronidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033939">
        <property type="term" value="F:xylan alpha-1,2-glucuronosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037054">
        <property type="entry name" value="A-glucoronidase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005154">
        <property type="entry name" value="Glyco_hydro_67_aGlcAse_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011099">
        <property type="entry name" value="Glyco_hydro_67_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011100">
        <property type="entry name" value="Glyco_hydro_67_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07477">
        <property type="entry name" value="Glyco_hydro_67C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07488">
        <property type="entry name" value="Glyco_hydro_67M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03648">
        <property type="entry name" value="Glyco_hydro_67N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="SSF55545"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 7" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0858">Xylan degradation</keyword>
    <feature type="domain" description="Glyco_hydro_67N" evidence="9">
        <location>
            <begin position="96"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_67M" evidence="11">
        <location>
            <begin position="194"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_67C" evidence="10">
        <location>
            <begin position="550"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AKH85738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="775" mass="85646" checksum="3D4A6168710110EB" modified="2015-07-22" version="1">MGAVAAGAALGASAGGPAGARDTEGAPFGPAGPRDDEYDGSDMWLRYVPVRDPHLLGQYRRQVTAVVVENADRNASYRHTPDLSMAPGSAERLMASTLEAAREELVRGLSGLLDRPVRALPRPGDVPPDGAVVVGTPESSRAVRRFLPAGELERAGRDGFVIRSVSQGRRAFTLIAGTTEVGALYGTFAFLRRIQTHKPITDLALTETPRVANRHLNYWDTERLYAGNDEAGTGGLRGENGAIFNFAATGASAPLNLPVVLDRYLVAARAMASVGINGITINNVNADNRYLTPAYIAQEAALADALRPYGIRLALSIRYAAPMDGRFAPDTLTEEQMAPTDADFRAWWTRRARRIQESIPDFLGFTVKANSEGQPGPQDFGYDHGDGANGMAAALAPLGLKIYWRTFVYNPDVDSDRLKRAYLEFGHIDDEAQPDGTSGRFLDNVFLQTKNGPLDFQAREPVHPMFGRMENTNQALELQITQEYTGQNRMLCFLAPMWEEILKTDTHATDARGRPLDRRLVGHVVDGTAQGHSDTAVVGVANLGNADNLTGHHFSQANLYAFGRQSWEWTADSADIAADWVRMTWSTNRKVVDAIVSMMMGSWEALVSYQTPLGIAHQFTADVHYGPGPSESHLPREDWNPVYYNKADSAGLGYDRSPTGSNFTAQYSPTLEAAYSDIDTVPENLMMWFHHVPWDRPMSSGRIFWDELVHHYYSGVRYVSGMRRTWDSLEPWLDARRFAEVRAKLALHETDAADWRDTCVSYWQRFSGRDVRVPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NEG5</accession>
    <name>A0A0F7NEG5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_17205</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH86840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="294" mass="30256" checksum="A5E94CEB3ACEF1A8" modified="2015-07-22" version="1">MYGFSRGNQALLSIAQPLVGALLATDHPAPGRLAAAVFATAAAFFAVFAANDLFDARLDRRSAAMARTRAAPDIDSTGGRHPLAQGRLRFAAGLAWVLLLGGIALAVAVALSWVCAVLFVGAALLEAAYCKLATVTAYKFLLSGAMVAIGACAGWFAFSATVDPLRLGLLALWMAAWEIGGRNIPNDLADVAEDTPLGIKTVPIVYGPRAAARLSAALLLLTAATACTLAVTAWPFYGAAGIAVTALTAIPTLVLPAARLLRHPEPPTALTVFNRASFHPLGVLAAFVAGSLVV</sequence>
</entry>
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            <authorList>
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
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        </location>
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            <begin position="132"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="AKH85112.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
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    </evidence>
    <sequence length="182" mass="19030" checksum="F9D64F6E4B52CC66" modified="2015-07-22" version="1">MRRRTRTALAALPLAVTLALTGCGSGGGDGTVATAGGEEKKSGGKDPVADDMDEQMLQFARCLRENGVDVQDPEPGQGVNLNMDGVGPAKAKRAMEACREYDPATLSKNDPISKELEEKLRAYARCMRSNGVADFPDPVPGGGLQMDGAIQQDPDYGGAAKACRKLMPAGEGESSTNEVEGE</sequence>
</entry>
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    <accession>A0A0F7NEI0</accession>
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                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6 7">CNQ-509</strain>
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    </evidence>
    <sequence length="272" mass="28228" checksum="C6439F200E2F16CD" modified="2015-07-22" version="1">MTAATTRTAPPDNDVLWARSLHYAHGGTPALAGVSLGVAQGEILAVLGPRGSGKTTLLKCLSGQLLPQQGEVWFNSGPVHTLSAGARERLRRDRFGWIGTRPELVPELTAWENVALPLLLAGDAHRVARRAAMEWLERLDAGGIARCRPAELPQQQRQHVAIARALVAGPDVVFADEPTAPLRRAEGMQALRTLVAAARSHGISVVLAGPEGDAAVAGAADRTFPLVDGRRASGARTAAEVAGYGDGAAAAGTEAGAARPTENSEDPCSVSA</sequence>
</entry>
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            <authorList>
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                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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    </evidence>
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        <source>
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    </evidence>
    <sequence length="289" mass="29710" checksum="B4D15E64E7423001" modified="2015-07-22" version="1">MKDFTAPDGTALAYHDSGGDGAPVVCLPGGPMQSSAYLGDLGGLTAHRRLIRLDPRGTGDSATPADPASYRCDRLVTDVDALRAHLGLDRLDLLAHCAGANLAVLYAARHPERVRRLALITPSVAAVGIDVTAEDRLAAARLRAAEPWFPGAYAALADLTAGRGGERGAIAPFFHGRWDDAARALDAASGEDRNAEAAAAYGAPGAYDPPATRAALARLTAPALVLAGEVDVNSPPPAMAAYAALFANARCAVQPAAGHHPWLDDPALFTAATAAFLTGSPTRAEELPA</sequence>
</entry>
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    <accession>A0A0F7NES7</accession>
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        <lineage>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_15640"/>
    <dbReference type="EnsemblBacteria" id="AKH86801">
        <property type="protein sequence ID" value="AKH86801"/>
        <property type="gene ID" value="AA958_15640"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_15640"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3295"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006827">
        <property type="entry name" value="Lant_deHydtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023809">
        <property type="entry name" value="Thiopep_bacteriocin_synth_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14028">
        <property type="entry name" value="Lant_dehydr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04738">
        <property type="entry name" value="Lant_dehydr_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03891">
        <property type="entry name" value="thiopep_ocin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lant_dehydr_N" evidence="1">
        <location>
            <begin position="39"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="domain" description="Lant_dehydr_C" evidence="2">
        <location>
            <begin position="747"/>
            <end position="996"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH86801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="1013" mass="108118" checksum="28CCF664BECA1783" modified="2015-07-22" version="1">MWRASTYGSDKHLPPWPGEAADAASWRSWLASVWTVGALGEAVTLASPSLADRIDQTLAGQECAVADLRHMATSLARYLIRLRGRATPFGTFAGVGSLRFGDRFRLSWKDDHRLLTRVDAVWLADIIARLEACPSLRERLPVVVNNLAFERGEKLVVPWQPHLATAVRSAGEDVAEVTVRRVPVVHTICQAAGTPVAAGTLAEKTAAEHPGASRDALMSVVGQLMASGVLISSLRALGTCTDPLGWLLSALDAAGAAAVPEVETVHAELRVLHHQMSGHGQVGAGGGKQHRRLVKDRMRALSSVTDQPLAVDLSLDADLVLPRSVAMEAADAAQALIRLTPQPSASTSWREYHHDFLARYGPGTLVPVIELTDSAGGLGYPRHFTVPSSKREFTPRDEALLSLAHQAALDGVSEIVLEEADLERIGPAADSASPVSPADLSVDLRARSHAALSEGEFTLAVSGFGRAGATTGRFLDLLEERDRGETTALYPSTVTGVAGAMAAQLSYPPRHVGSENVLRVMPVLPHVISLAEHRHGDGHLPLTDLAVAADTTRLYVVSRSQRRVVEPMLPHAGARHTMPDLARLLFEIPRSTHPAVTAFDWGAAACLPYLPRACYGRSILAPAQWRIDPSDLPGPKAPAQQWAAAWQALRHRRQLPSTVAVADGDRRLRLDLDQTMDWALLRSHLQAADGPVTVAEAPNGTEHGWCGGRAHEIVIPLAPTAPPAASPSFLTSVPPPVADSRAGGGVLFAKLYGPSGTADDILTRHLSALLTRWTEPPKWWFVRYRHPCPHLRLRVRDADTARAAGHLAAWAGELRQAGLAGEIAFDTYRPETGRYGAGESMNAAEHLFAADSAAVLAQLAFLDAHREIPPQALTAASMADLAAAIMGGRQAGLGWLLDHPQYADGAGPQDRQTRGHMLRLAHDGALETLPGGSDLAAAWAARTQAAAAYTARLTITGNLPAPATVLGSLLHLHHVRAHVPGGTSEATTYKLARAVALAGATRHTDRQHREGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NEZ6</accession>
    <name>A0A0F7NEZ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_27180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018537.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_27180"/>
    <dbReference type="EnsemblBacteria" id="AKH85302">
        <property type="protein sequence ID" value="AKH85302"/>
        <property type="gene ID" value="AA958_27180"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_27180"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5727"/>
    <dbReference type="OrthoDB" id="853902at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046038">
        <property type="entry name" value="DUF5996"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19459">
        <property type="entry name" value="DUF5996"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH85302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="310" mass="34338" checksum="C56EB4A85DF539E1" modified="2015-07-22" version="1">MTNVLPTADPWPALRVADWADTRETLHMWTQIVGKVRLALAPMVNHWWQVAFYVSARGLTTSAIPGRRTFDMEFDFIDHQLRLRTTAGAVETVALEAKPVADFYRETMAALERAGVDVSILARPVEVEVAIPFAEDRTHAAYDPAHAHAFWGQLVQASRVLNEFRSGFIGKVSPVHFFWGGMDMAVTRFSGRTAPVHAGTTPNCPDWVMTEGYSHELSSAGFWPGGDGEGMFYAYAYPEPPGFSDHPVPAGAYSPEWKQFLLPYETVRTAADPDALLLGFLQSTYEAAALHGDWDRAALEDDPARRAGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NF90</accession>
    <name>A0A0F7NF90_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_31590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019236.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_31590"/>
    <dbReference type="EnsemblBacteria" id="AKH86008">
        <property type="protein sequence ID" value="AKH86008"/>
        <property type="gene ID" value="AA958_31590"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_31590"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6672"/>
    <dbReference type="OrthoDB" id="1864489at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025333">
        <property type="entry name" value="DUF4239"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14023">
        <property type="entry name" value="DUF4239"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="254" mass="27906" checksum="EE81FD39B4347F90" modified="2015-07-22" version="1">MSEWLMLTLAMAAAIAVVVLITVLRHRRPDEEFDPTETPDVIEYMTMMIGVVYAIVLGLAIAGVWEAKGSAEDSVQREAFALHETSERLAEYPAPVREEIRADIAAYVGYAVHEEWPAMQDGEGLSERGDELLDEVRRGLFAYAPETDAENRAAYALGDQIAAAEEARNERALNSGPTMPSLVWFGLIAGGLVAMGMVFALQIQRSVRELILAGLHSGLLAFLLFLVWEFDQPYVRDSAGMLEPFTTLFPKAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFC8</accession>
    <name>A0A0F7NFC8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_22975</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020340.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_22975"/>
    <dbReference type="EnsemblBacteria" id="AKH86976">
        <property type="protein sequence ID" value="AKH86976"/>
        <property type="gene ID" value="AA958_22975"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_22975"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4840"/>
    <dbReference type="OrthoDB" id="913949at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="31"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH86976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="284" mass="31828" checksum="12E060CEEB0A9639" modified="2015-07-22" version="1">MADGTVETGGGGGYGSEPEPSDSMRTFGAVVQALREHAGLNREQLGERVRYSKHTVASIEGGRRMPPPDFVERAEPVLGNTGALRRSAPHLARRPGLARWFREWARLETEAITLYTYESRVIPGLLQTEAYARASFRNQLPPLSAAQIQDQWEARAERQSLLRERVNTAFSFILEEHLLLRRLGGVEVTRGLIDHLLEIARLPNVELQIMPQVRETHAGLAGPMQLLETPENRWYAYSEAQRGGLFISDLKEISVLQQRYARMCAQALTSEDSVSLLLQMRGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFG2</accession>
    <name>A0A0F7NFG2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_33735</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020662.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH87215">
        <property type="protein sequence ID" value="AKH87215"/>
        <property type="gene ID" value="AA958_33735"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_33735"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.7123"/>
    <dbReference type="OrthoDB" id="1959257at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH87215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="126" mass="13620" checksum="C149A2720C988635" modified="2015-07-22" version="1">MESRLEEAINEWHASVNAGDLQRSAGAVGDPVVVLGPKGAGPITPAQFAEWVERSGIKLTPRSWHPVSERLMVVEQDATWPKSTQVTRVATVFRAAGGKITAALRLPDLRAALDLAYICREMAATE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFK4</accession>
    <name>A0A0F7NFK4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">UDP-N-acetylglucosamine 1-carboxyvinyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_33030</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019471.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_33030"/>
    <dbReference type="EnsemblBacteria" id="AKH86244">
        <property type="protein sequence ID" value="AKH86244"/>
        <property type="gene ID" value="AA958_33030"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_33030"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6978"/>
    <dbReference type="OrthoDB" id="537477at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008760">
        <property type="term" value="F:UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019277">
        <property type="term" value="P:UDP-N-acetylgalactosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01555">
        <property type="entry name" value="UdpNAET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001986">
        <property type="entry name" value="Enolpyruvate_Tfrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036968">
        <property type="entry name" value="Enolpyruvate_Tfrase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005750">
        <property type="entry name" value="UDP_GlcNAc_COvinyl_MurA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00275">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="SSF55205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01072">
        <property type="entry name" value="murA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="4" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="EPSP_synthase" evidence="7">
        <location>
            <begin position="9"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH86244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="435" mass="46443" checksum="90C494D8699B63A1" modified="2015-07-22" version="1">MNGKLWQIEPSGPLRGDVTVRGAKNAVSKHMVAAMLGSGPSTIRNAPDVGEVGITARMLEHVGMKVERTDGEVTVVPAPVADPSVDKAFTGLNRIPILLLGPLLHLTGEAFVPMVGGDPIGRRPVDFHLDALRRFGAEVELAEDGIHARAARLRGTRIDLPYPSVGATETVLLTAVRAEGRTVIRNAATEPEIVELALFLQRMGARISLYPDRRIVVEGVDALGGATTRLGGDRIEAFSYLVAGLVTGGEVRVHGCPQDRLVTPITTLARMGARFEITDEWITASAPRTLRAAAVQTDTHPGFATDWQTPLMVLFTQAEGMSVLHETVYENRLAYVSALQGMGAEIEVYDTCLGGPACRYHDTGALHSAVVRGVSGLRGGDVTMPDIRAGFSAVLAAAVATGGSTLRGVHHIERGYHRPVEQFRALGLELRSVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFN9</accession>
    <name>A0A0F7NFN9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phosphonate ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_29505</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_29505"/>
    <dbReference type="EnsemblBacteria" id="AKH87116">
        <property type="protein sequence ID" value="AKH87116"/>
        <property type="gene ID" value="AA958_29505"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_29505"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6226"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015416">
        <property type="term" value="F:ABC-type phosphonate transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03256">
        <property type="entry name" value="ABC_PhnC_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012693">
        <property type="entry name" value="ABC_transpr_PhnC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02315">
        <property type="entry name" value="ABC_phnC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="1"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH87116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="256" mass="27711" checksum="DD7F1E36A1EE095B" modified="2015-07-22" version="1">MQFREVSKRFGADTLALDGLSLRIEAGEVVVLLGLSGSGKSTLLRHIDGLHQATSGTVNVLGTDVGRARNKELRHLRRRVGFIFQQFHLVRSLTVLENVCTGALGTLRGPRLGLPTFPKRVRFEALEHLERVGLSAQALQRADTLSGGQQQRVAVARALMQRPEILLADEPVASLDPESSSQIMQLIRDISQERELTVVCSLHQVDLALSWGDRVVGLRAGRMVLDTPVKGLKRDQVMAVYAGVGADAAAVLAATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFU6</accession>
    <name>A0A0F7NFU6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Molybdopterin dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_32710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019420.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_32710"/>
    <dbReference type="EnsemblBacteria" id="AKH86193">
        <property type="protein sequence ID" value="AKH86193"/>
        <property type="gene ID" value="AA958_32710"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_32710"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6911"/>
    <dbReference type="OrthoDB" id="1017413at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005107">
        <property type="entry name" value="CO_DH_flav_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036683">
        <property type="entry name" value="CO_DH_flav_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002346">
        <property type="entry name" value="Mopterin_DH_FAD-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03450">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00941">
        <property type="entry name" value="FAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01092">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55447">
        <property type="entry name" value="SSF55447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="331" mass="35116" checksum="B3B9DF8187CBAFC4" modified="2015-07-22" version="1">MIPFEYRRAADAREAVATVAARPDAVFLGGGTNLVDHMKLGVATPDMLVDVSRLPLTEVEETPGGGLRIGATVRNSDLAAHPLVRQRYPALARALLSGASGQLRNAATTGGNLLQRTRCRYFQDVTTPCNKREPGSGCAAIGGWDRHHAVLGASELCIAVHPSDMAVGLVALDATVHVLGPDGARTLPLSDLHRLPGDAPERDTVLAHGELITAVELPPASGMTRRSTYRKVRERASYAFALVSVAAALDLDDGGVVRDARIALGGVAHKPWRAERAEDVLRGAPAAEESFRLAADAELAAAEVRDGNAYKVPLARNTMVAVLRDLTEARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFU9</accession>
    <name>A0A0F7NFU9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">LacI family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_31690</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH87176">
        <property type="protein sequence ID" value="AKH87176"/>
        <property type="gene ID" value="AA958_31690"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_31690"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6692"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH87176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="334" mass="36160" checksum="4E944140E58F9CAD" modified="2015-07-22" version="1">MTLAEVATQAGVSLSTVSKVLNGRSDVSRPTRSKVEQLLETHGYRRRAQAAPQAPLIELVFHELESVWAMELIRGVENVAKQNHASVVLTESGTRHAPDPDWIEGVLRRRPLGVVLVFSTLPDRVKKQLRSRAIPFVIVDPAGDPEPDVPSVGSANWAGGMAATRHLIERGHRRIAIITGPEDMMCSLARLDGYRSAMAMAGLDVDPAQVRFGDFHVQGGFDHAMELLDGPGRPTAVFAGSDLQALGVLEAARLKGLSVPDELSVVGYDDVPLAQWSSPALTTVHQPLRQMAEEAAQMLLRPREPGKGALRMELATRLVVRQSTAAPEEPPSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFV7</accession>
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        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
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    </dbReference>
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            <begin position="20"/>
            <end position="35"/>
        </location>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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            <dbReference type="EMBL" id="AKH86203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="112" mass="12641" checksum="C2C3D6F02078127F" modified="2015-07-22" version="1">MSEQRERRARPAAKSTSKRASGSKADHAVDEPEEAARRACRSLARLITHEAEGVSAVRRAEEGWRVHVDVLEVPRIPDTTSLLATYAVELDSGGRLVEYERIRRYRRGARDD</sequence>
</entry>
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    <accession>A0A0F7NFW8</accession>
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                <person name="Winkler A."/>
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                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
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        <property type="gene ID" value="AA958_32870"/>
    </dbReference>
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    <dbReference type="PATRIC" id="fig|444103.5.peg.6944"/>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="AKH86218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="110" mass="11460" checksum="9E714FD941BD34F4" modified="2015-07-22" version="1">MVKAADAPHLLLDEVCRLLTAAGFDVTAGGGEGTAGLHVRRSVDAVVVRWEPGAALDPAGRGHNEHDGIRAALRYALLATLTQAGHAVDVDHDSDDVHVREPVRTEPAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NG84</accession>
    <name>A0A0F7NG84_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="2 3">
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        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH80827">
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        <property type="gene ID" value="AA958_00030"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86444">
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        <property type="gene ID" value="AA958_34230"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_00030"/>
    <dbReference type="KEGG" id="strc:AA958_34230"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6"/>
    <dbReference type="Proteomes" id="UP000034283">
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    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH80827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="86" mass="9143" checksum="FAAC7F60432F78BC" modified="2015-07-22" version="1">MTCSQLEDLTPRQQIEYLLQAAAACEQANAAELRAAAFSDIGTALVNADEREKAAAYFLQAQNILEELGLTEQAAADREGGAALQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NGJ4</accession>
    <name>A0A0F7NGJ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_33975</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019635.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_33975"/>
    <dbReference type="EnsemblBacteria" id="AKH86413">
        <property type="protein sequence ID" value="AKH86413"/>
        <property type="gene ID" value="AA958_33975"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_33975"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.7174"/>
    <dbReference type="OrthoDB" id="1688736at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="58"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="204"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="250"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="312"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="121"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="22"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH86413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="338" mass="36472" checksum="B3BB0875D859E876" modified="2015-07-22" version="1">MTAPHPHRQEARAGGGSPSGPQLKGSPPPAPRASARAGRPPRPGRAHRVERWLGRHPLGLALTAPYTVFVLVVFAIPFGFGVWMAFHDYFFTAPGVSVPHPFVGFDNFTAVLGDGDTRRAFRNLGVFMAINIPLTVVLALSLAAALNSATRWRVFFRVSYYVPYVTASVATLAVWLFLFNGSGAVNHALGAWAPEPSWLANKHLVMPLIALYVTWKQLGFYVLLYLAALQNVPRELHEAALTDGAGRWQAFRAVTLPAVRPVTSLVILLSLITSGQIFTEPFLLTGGGPNGASLTPALLIYQRGLEQGEPDAAAAIGLILVTAVLILATISRRVMERN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NHB4</accession>
    <name>A0A0F7NHB4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_11125</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_11125"/>
    <dbReference type="EnsemblBacteria" id="AKH86683">
        <property type="protein sequence ID" value="AKH86683"/>
        <property type="gene ID" value="AA958_11125"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_11125"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2343"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012318">
        <property type="entry name" value="HTH_CRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13545">
        <property type="entry name" value="HTH_Crp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00419">
        <property type="entry name" value="HTH_CRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51063">
        <property type="entry name" value="HTH_CRP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="HTH crp-type" evidence="3">
        <location>
            <begin position="135"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH86683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="214" mass="22640" checksum="3819D4FA7CF34CA4" modified="2015-07-22" version="1">MLRGLPQDRLRALWRASVPRRFAAGGVLRTAGDPAGHLLLLLDGRVAATVVSAGGRVVRVGAWAGPCALDKVAVVDGRGHTATYTALTPCTVRSLPRADFLALVDDAAAVRAHVLRTLAAQARDQQARFTAAATLPAPARLAAWLLDEAARRRSRRVPLPGGQQALADHLGVTRVTLNRALSGLRRDGVLTYAHGEIEIIAPETLALRATPGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NHL0</accession>
    <name>A0A0F7NHL0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_32960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019459.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_32960"/>
    <dbReference type="EnsemblBacteria" id="AKH86232">
        <property type="protein sequence ID" value="AKH86232"/>
        <property type="gene ID" value="AA958_32960"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_32960"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6964"/>
    <dbReference type="OrthoDB" id="537440at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase" evidence="1">
        <location>
            <begin position="18"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="347" mass="37141" checksum="E51EC36AA3039BD6" modified="2015-07-22" version="1">MNLRDQPLKAVAAAAEPRAAVVVAVFAGGTYRALCRGGVDRKGTASVTDRTRFEVGSVTKTFTGLLLADTAARGEVSFTDRIAERLPYAALPRGHGRAITYEHLATHTSGLPRLPPGLVLNGLPSWFANPYRSFTPEMLLPALGRAVVHHPPGTLMRYSNLGVGLLGRLLADGAGTDYGSMLRERVLDPLDLTDTGTAAPAAPDPAYAVGYWHGRRRPPWVIPALPGAGAVRSSAHDLIRFLRAHLHPEDSDTPQPLRIPLAEAVRIRELPAGYEEKSGLAWSVRTLSGATLYFHSGTTRGCTAFAGLSPEREVCVVALTNSGVTLRSRFVQSSYLLLRALALGEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NHY3</accession>
    <name>A0A0F7NHY3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aminotransferase class III</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_33550</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019559.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_33550"/>
    <dbReference type="EnsemblBacteria" id="AKH86337">
        <property type="protein sequence ID" value="AKH86337"/>
        <property type="gene ID" value="AA958_33550"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_33550"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.7085"/>
    <dbReference type="OrthoDB" id="493793at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1 2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="460"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH86337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="480" mass="49724" checksum="635B0416A10E8309" modified="2015-07-22" version="1">MSPGPDVTTAGAGAALAARAQRVVPGGVNSGQRSIPGLPGLVVAGTGGARFRTADGAEFTDYHAAFGPPLLGHNDPDVARAAAEAGAALGHMGVGVTEGEIELAEELCALVPSLEKVLLTSTGSEATFHALRVARAATGRRLVVKFQGCYHGWHDAVSLNVISAPDRVGGHDPISAGILPEVLDATMVLPFNDSAAVRRCFAEHGAAIAAVIVEPVPHNVGALLPHREFLTTLREETARAGSVLVFDEVITGVRHDLGGWQRISGVTPDLTTLGKAIANGAPAGAIGGRADLMELFSTRPGAPAFFAGTYNGHPSVVAAALATLKKLREEPVHDHVFRLGERVRTGLRTVYARLGVPVAVTGYGSVFVTYFMPGYDGGTAGAEAPAPRTYSDLLANDAALFVGYRRRLLEHGIFELPLNLKRSHLSYAHTDADVDRLLEATEAAVTAALADGGARDLEHASTMGGAAPAAAAGRRQEAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NI43</accession>
    <name>A0A0F7NI43_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_21160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020289.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_21160"/>
    <dbReference type="EnsemblBacteria" id="AKH86938">
        <property type="protein sequence ID" value="AKH86938"/>
        <property type="gene ID" value="AA958_21160"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_21160"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4457"/>
    <dbReference type="OrthoDB" id="1284178at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="18"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="283" mass="31328" checksum="9CEC63A8A44167D1" modified="2015-07-22" version="1">MAARNTPTERQKRLGIEVRKIRTSAGMSATYAAGLLGVDSGKISNMEFGQRTITPERLRTLACNCHCTDEKYVEALIAMAQPGEKGWWERYRGSLPHGLLDIAELEAHASRMRIGTTVHVPGLLQTSDHALAVFREVMPPLPEDEVGLRLALRAKRQQVLLGTNPPGYVAVVHEAALRMQFGGRLVARGQLQHLLDASDREKVTVRVIPFERGSFPGAGQNIFYAEGPVPQLDTVQIDNSHGPDFLHAEGQLAKYRAQLDRQEDAALPPDESRAFIREIARQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NI50</accession>
    <name>A0A0F7NI50_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_00045</name>
        <name evidence="2" type="ORF">AA958_34215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH80829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH80829">
        <property type="protein sequence ID" value="AKH80829"/>
        <property type="gene ID" value="AA958_00045"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86442">
        <property type="protein sequence ID" value="AKH86442"/>
        <property type="gene ID" value="AA958_34215"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_00045"/>
    <dbReference type="KEGG" id="strc:AA958_34215"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.7235"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH80829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="78" mass="8501" checksum="B8D8B39759E0A97F" modified="2015-07-22" version="1">MLYLFGSTANIPVVLWREVRPWRTALIFEVFAAIAQTLHPVELLMTTLNKSVADPLGFGAGGITADPVMVALTVLPDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NI66</accession>
    <name>A0A0F7NI66_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_30360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_30360"/>
    <dbReference type="EnsemblBacteria" id="AKH87144">
        <property type="protein sequence ID" value="AKH87144"/>
        <property type="gene ID" value="AA958_30360"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_30360"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6414"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="PTHR11895"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="SSF75304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH87144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="442" mass="45877" checksum="F57D87AD4B67094C" modified="2015-07-22" version="1">MLDAIRADTTGAYVAVAGEGALRAAREADALIRERGAAAWLERPLLGVTVSVKDLLQTGDLPTGRGSLLPNTRPPEDTPAVARLRAAGAVVVGKTATSEYGWSASTVRRVGPPVRNPYDPRRTAGGSSGGAAAAVATGMCDGALGTDGAGSVRIPAAFCGVVGYKPSYGRIPYVPGSIERLSHQGTLARRVEDAAALAAVAAGPHPYDPDSALGSLDPERSSRRLRVGWVEYERTGAGVREVTERALGAFAGRGHRVERIEVRCDGLYPALVDILAAAEAAATGPEDEELCDPGRLEVVRHGRILSGTAVIRAEEVRHALRTKLRSVMDRYDLLAMATVPVEPFDAGAIAPEWAADPRDLLWLAWSPATYPFNMTGQPAVSVPAGLTPAGLPAGVQVVGPVGADALVLATAARLETDLGALPAPWAAQPPPAPAALPVVERI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NI78</accession>
    <name>A0A0F7NI78_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_22825</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020336.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_22825"/>
    <dbReference type="EnsemblBacteria" id="AKH86973">
        <property type="protein sequence ID" value="AKH86973"/>
        <property type="gene ID" value="AA958_22825"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_22825"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4805"/>
    <dbReference type="OrthoDB" id="418702at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013495">
        <property type="entry name" value="CHP02679"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024466">
        <property type="entry name" value="CHP02679_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024465">
        <property type="entry name" value="DUF2399"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09664">
        <property type="entry name" value="DUF2399"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11796">
        <property type="entry name" value="DUF3323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02679">
        <property type="entry name" value="TIGR02679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3323" evidence="2">
        <location>
            <begin position="32"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2399" evidence="1">
        <location>
            <begin position="251"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH86973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="404" mass="42148" checksum="AB14C988531F728B" modified="2015-07-22" version="1">MDPDRLTRLLGGPGLDWLVERARRRLARGEPLTGTVTLASATAAQRGAAERLLGRAPRPGRSLSVRLDEVDAVLRRSRVSPAGLAAAVTALTGPVVPLAEARERQARAWEEAYAPLAALPAELADWADDIRRDGLVRRLARSPDAARPLLAATVSALGALPAEPARPLPEFAAQTLGDAHALDDGTPLATLVRSGVRALTGFPDGEGAEWRRAAWASAGLLKDALSATVLALGVRGTAALDALADAGEPAVLTLRQLAHGAPRPPATAPAVYVCENPAVVAAAADAYGADCAPLVCLQGQPSAAALTLLRLLQSAGARLLYHGDFDWGGLRIAGGLLRRVPWRPWRYTAADYRAAAATMPLARPLRGTPASAPWDPALSAALTEVGVGVEEESVIDDLLSDLIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NIC4</accession>
    <name>A0A0F7NIC4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_32385</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020630.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_32385"/>
    <dbReference type="EnsemblBacteria" id="AKH87194">
        <property type="protein sequence ID" value="AKH87194"/>
        <property type="gene ID" value="AA958_32385"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_32385"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6836"/>
    <dbReference type="OrthoDB" id="1538300at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="204"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH87194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="354" mass="35831" checksum="E6F89D1D0A97596A" modified="2015-07-22" version="1">MLTTAGTAAQPDSPPPHAEAAHGPAVTATAVVQDRAGRVLVLLPAEPAADAEPVLPGVAVSGRQTPEEALTRALRDALGADLPAGRLLAVDSVPAAGGRAGLAHLYAAAPPPAALTAAPGAAGDGDPAGLTTSWLDRDAALAALPALDARRLRAALDAWDTGAVAHLVGGEPQPGSCAAVSARRRAELEHAAALDPSSYLAVRPRVLVGAGALVRDSAGRLLLVRAGYRDDGRWQLPGGGVDSDLGETPRPAARRELREETGLDRPLGRLLAVDFASRRPAPALVVYVYDGGVLDAADLAGVRVDGTEIVDWRLAAPDEFDDLLPPRGAAIARAGLGALEDGGGPLDLVAGRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NIG6</accession>
    <name>A0A0F7NIG6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UBP-type zinc finger protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_27175</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020448.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_27175"/>
    <dbReference type="EnsemblBacteria" id="AKH87058">
        <property type="protein sequence ID" value="AKH87058"/>
        <property type="gene ID" value="AA958_27175"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_27175"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5726"/>
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        <location>
            <begin position="50"/>
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        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH87058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="119" mass="12652" checksum="1472B31F564F08AA" modified="2015-07-22" version="1">MDAERMSGIDPASTPSGEGCAGCVAGEGPGWWFHLRRCAACGRIGCCDSSPSQHASRHARESGHPVLTSFEPGEDWFWNADTGQFVDGPAMSPPHAHPDGQPVPGPAGKVPQDWQQHLH</sequence>
</entry>
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        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6 7">CNQ-509</strain>
        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AKH86992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="447" mass="46820" checksum="39EE576D6DD17508" modified="2015-07-22" version="1">MCALLATAACAAPALLPGAATPWAALALLAVVYAAGEHLWRVPPLAGRVPDGIGAFFPVLLAGAFLLPPSAAALVPLPGALTARIAEQPAAPRRLWRAAELALAGWAAAYAAGRMPGDARLGEAGIPELLPAALAAVAAFWTVLTCLAALMQAAAERRSPRAALAGAPAAAGTYLVHGLAGLMMAMLWHSPHGPASGLLVLLPMAISCWAFAQANRERAAHQATIRALVQAVDIKDRYTRGHSERVGRASVLIARELGMDERRQEVLRFAGILHDVGKLGVPTRILRKDGPLTPEERRVIELHPEYGHEIVRGIGFLEEVRSAILHHHERMDGGGYPYGLTGEAIPEYARVVAVADAFDAMTSTRSYRRAREVPAALAELRRCAGAQFDPRMVRALAGAIGRRGWHAEVTADEPAAVPAPLRGGAGERRGDGAAGGTADVVRSGGAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A097H0Y9</accession>
    <name>A0A097H0Y9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cyclohexanone monooxygenase</fullName>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="ChemBioChem" volume="15" first="2385" last="2392">
            <title>A Membrane-Bound Prenyltransferase Catalyzes the O-Prenylation of 1,6-Dihydroxyphenazine in the Marine Bacterium Streptomyces sp. CNQ-509.</title>
            <authorList>
                <person name="Zeyhle P."/>
                <person name="Bauer J.S."/>
                <person name="Steimle M."/>
                <person name="Leipoldt F."/>
                <person name="Rosch M."/>
                <person name="Kalinowski J."/>
                <person name="Gross H."/>
                <person name="Heide L."/>
            </authorList>
            <dbReference type="PubMed" id="25224759"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
    </reference>
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        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KJ451628">
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    </dbReference>
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        <property type="protein sequence ID" value="AKH85749.1"/>
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    </dbReference>
    <dbReference type="RefSeq" id="WP_047018977.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_29960"/>
    <dbReference type="EnsemblBacteria" id="AKH85749">
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        <property type="gene ID" value="AA958_29960"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_29960"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6326"/>
    <dbReference type="OrthoDB" id="630753at2"/>
    <dbReference type="Proteomes" id="UP000034283">
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    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
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        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        </location>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AIT42138.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AKH85749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="540" mass="60026" checksum="F552BE6E1DF35C69" modified="2015-01-07" version="1">MPRKPTHLDSIVIGAGFAGIYMLHKLRNTLGLNVRAFERGAGIGGTWHWNRYPGAAADVDSIAYRYSFDSDLLREWNWKTRYAPQPEILAYLEHVVDRYDLREDIQLNTTVESLAYDESSGLWTVRTDGGEEFTARYVVGALGPLSAASFPEIEGRDRFAGTQVHTGAWPEDLDITGKKVGVIGTGSTGTQFIGAAAKMAEHLTVFQRSAQYVVPAGDGPLSDEFIEDYRENHKQFWEKAFNSRVACGFEESQISAMSVSAEERERRFQESWDAGNGFHFMFGTFADIAFNPESNDAAASFIRSKIKEIVRDPETARKLMPTDLYAKRPICNTDYYETYNRDNVTLVSTKENPIVRITPAGVVTEDGTEHELDVLVFATGYEAMQGSYNRIDIRGRGGVSLREYWGEEPSSYLGMAVNGFPNLFTVFGPNSVFSNLPPALQTQVEWIAETIDAARKRGAGTVEATATAEKEWTAMCRVMAEHSLFAQTDSWIFGSNIPGKKRRTLFYFGGIAAYRAKLGEIVAADYEGFTLDGEVSLTAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MZ39</accession>
    <name>A0A0F7MZ39_9ACTN</name>
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    </gene>
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        <lineage>
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_01065"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.234"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH80991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="60" mass="6703" checksum="C8B6452901F8C805" modified="2015-07-22" version="1">MHRRHSVRLEGRVLVSLPTLLVAFARYSRDGSLGMFPNLVLIPLLAVILLVSAIKLARHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MZ95</accession>
    <name>A0A0F7MZ95_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Beta-N-acetylhexosaminidase</fullName>
            <ecNumber evidence="3">3.2.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_04735</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="3"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014970.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_04735"/>
    <dbReference type="EnsemblBacteria" id="AKH81615">
        <property type="protein sequence ID" value="AKH81615"/>
        <property type="gene ID" value="AA958_04735"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_04735"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.998"/>
    <dbReference type="OrthoDB" id="727559at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004563">
        <property type="term" value="F:beta-N-acetylhexosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102148">
        <property type="term" value="F:N-acetyl-beta-D-galactosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025705">
        <property type="entry name" value="Beta_hexosaminidase_sua/sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015882">
        <property type="entry name" value="HEX_bac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600">
        <property type="entry name" value="PTHR22600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02838">
        <property type="entry name" value="Glyco_hydro_20b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00738">
        <property type="entry name" value="GLHYDRLASE20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="SSF55545"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519595" description="Beta-N-acetylhexosaminidase" evidence="6">
        <location>
            <begin position="35"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="7">
        <location>
            <begin position="49"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="27"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH81615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="785" mass="85188" checksum="938B4F3AF3110B10" modified="2015-07-22" version="1">MSAPSEEQTVRRRTVLAAAGSAALVAASATPALSAPAPAAAPAAADGPAADAAWPDPARDVARDGTATASSVYDRDPARFAAAHVNDGDLSTRWGSNSPENGYPDPSREWVQIELAEPSPVHHVVIHWETARAAHYQIHVSDDGETWRTARDVPDAPGGREVLELGLTTAVRYVRMQGVAVATGWGYSIFAMEVWNGPRPGVGLPAGRVIPVPVAQTSQPDARPFVLDRRSRIVAADPKARAVAGLLAGYLRPATGYPLPVVTGPARDGDITLLLGRAHAPSRARLAVAEGYTLAAGERGVRIAAATPHGLLNGVQTLRQLLPPWIESDTAGPGPWTVEATEIRDHPRFAHRGLMIDPARNFLEVREVRELIDGLVQSKGNVLHWHLTDDQGWRVEIDSWPRLTEVGGGMSMPGGRTGFYTKDQIRDVVRYAAERHVQVIPEIEMPSHTTAARTAYPQLSGAGGYLADLETTYAFVDDVLREVAALFPSRYVHLGADESDMPHDQYVRFLRRVEGIARGHGKTMIGWSPSCGVGLDTETVHHYWQDQSREMSREWFDPRRPVLLSPTQQTYLDYPYPTYDTRRAYSWNPSDLTDGWTGAKVQRDYGLNNEDIIGIEAPIWGERMLRGLPDVQYQVFPRLPAILEKAWSPAEVTEDAEGVVARTGVQGARWLFAGRNFWADPGVRWEPAAVGADLRADRDGTVSGAVARLALPGVAPAGVTATVEWGDGTTGPATVTGDAPGDRQINGVYRIEAGHRYARRGTYRGTVHLTTPTGRTTARFTATHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MZH5</accession>
    <name>A0A0F7MZH5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase family 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_01805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014475.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_01805"/>
    <dbReference type="EnsemblBacteria" id="AKH81111">
        <property type="protein sequence ID" value="AKH81111"/>
        <property type="gene ID" value="AA958_01805"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_01805"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.393"/>
    <dbReference type="OrthoDB" id="724641at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017832">
        <property type="entry name" value="Glyco_trans_2_hopen-assoc_HpnB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03469">
        <property type="entry name" value="HpnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="287"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="311"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="347"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="384" mass="40964" checksum="E850409BFA5723A5" modified="2015-07-22" version="1">MTLLAWIVLFSLAAWGWLLLGQGLFWRTDVRLPLRPPPAQWPSVAVVVPARDEAAVLPDSLPSLLAQAYPGEARVFLVDDGSTDGTAETARALAEKAGDRALPLTVSSPGEPPEGWTGKLWALRHGIGQAYRADAEYLLLTDADIAHRPESLRELVAAAEAGGYDLVSQMARLRTATGWERLVVPAFVYFFAQLYPFRWVNRAGGRTAAAAGGCVLLRADAARRAGIPEAVRGALIDDVSVAREVKRTGGRIWLGLAERVDSVRPYPRLAGLWGMVSRSAYAQLRHSPLLLAAAVGGLALVYLVPPLAVAAGLLGGAPAVAVAGALAWAVMAGTYLPVLRYYGQPPWAAALLPFTAGLYLLMTVDSAVRHHRGKGAAWKGRTYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MZK0</accession>
    <name>A0A0F7MZK0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_01955</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014500.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_01955"/>
    <dbReference type="EnsemblBacteria" id="AKH81136">
        <property type="protein sequence ID" value="AKH81136"/>
        <property type="gene ID" value="AA958_01955"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_01955"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.422"/>
    <dbReference type="OrthoDB" id="1584669at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="94"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="128"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="95"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH81136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="311" mass="34599" checksum="D04328FF46F6F6C4" modified="2015-07-22" version="1">MTADIPTATTPRPAAAPAGKPDREAGKRPRRGRFGVHIFLGGVSLAFLAPLLLAVYASLRPYEETAEHGYFSFPRKLSFDYYRQAFSDSEMSKYFVNSLIIAVPGVLIVLFLASFAAFVLARLRIRGGFFLLILFTAGNLLPQQVIVTPLYVMFNRIELPYWMSESMTMYDSYWAVISVNVGFQLGFCVFVLANFMRALPTEILEAAVVDGAGVWTQYWRITLPLCRPALAALGTLQFTWMYNDFLWALVFISDGDKLPITSALNNLRGQFFTDYNLLAAGSVLVALPTIIVFLLLQRHFIAGLTLGSTKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MZN3</accession>
    <name>A0A0F7MZN3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sugar isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_05655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015124.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH81770">
        <property type="protein sequence ID" value="AKH81770"/>
        <property type="gene ID" value="AA958_05655"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_05655"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1184"/>
    <dbReference type="OrthoDB" id="1605411at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05013">
        <property type="entry name" value="SIS_RpiR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035472">
        <property type="entry name" value="RpiR-like_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13580">
        <property type="entry name" value="SIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SIS" evidence="1">
        <location>
            <begin position="37"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="253" mass="25823" checksum="12630720DB80BBE9" modified="2015-07-22" version="1">MTLKPISAAAFTAAALTSLRRVAEGQRAEVGAAATVFADALGGDGVIQAFGTGHSESLATEIAGRAGGFVPTNKIALRDLVIYGGEPPALLSDAKLERDPATARRLYELAAPHPADAFVIASNSGINGCVVEMAAVVKEQGHPLIAVTSLSHGARAESRHPSGKRLTDHADVVLDNGAPFGDSVLTLPGGGTACAVSSITGALLVQQVVAEAVRLLLERGVTPPVYLSANIPEGDAHNAALEARYAGRIRRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N070</accession>
    <name>A0A0F7N070_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Amine oxidase</fullName>
            <ecNumber evidence="3">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_06970</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <cofactor evidence="3">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="3">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <text evidence="2">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="PTM">
        <text evidence="2 3">Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the copper/topaquinone oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="3"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015351.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_06970"/>
    <dbReference type="EnsemblBacteria" id="AKH82000">
        <property type="protein sequence ID" value="AKH82000"/>
        <property type="gene ID" value="AA958_06970"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_06970"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1457"/>
    <dbReference type="OrthoDB" id="611729at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008131">
        <property type="term" value="F:primary amine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009308">
        <property type="term" value="P:amine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000269">
        <property type="entry name" value="Cu_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015798">
        <property type="entry name" value="Cu_amine_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036460">
        <property type="entry name" value="Cu_amine_oxidase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638">
        <property type="entry name" value="PTHR10638"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01179">
        <property type="entry name" value="Cu_amine_oxid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49998">
        <property type="entry name" value="SSF49998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0186">Copper</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0801">TPQ</keyword>
    <feature type="domain" description="Cu_amine_oxid" evidence="5">
        <location>
            <begin position="75"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="293"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="437"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="293"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via topaquinone" evidence="1">
        <location>
            <position position="220"/>
        </location>
    </feature>
    <feature type="modified residue" description="2',4',5'-topaquinone" evidence="2">
        <location>
            <position position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH82000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="460" mass="50750" checksum="5B88558DC8883456" modified="2015-07-22" version="1">MRNPTTHGPDAPDAGSGAPAGRRGGAFWRRPATWRGGAVAALVLLLPAAAPAALPTAGAATPTAPQAAAPDCSEEYRITHKLPNGTEWQMCYRNNDYAGLVLEDISYKPKGARSAVPVLNSARLGQIHVPYDDGGIEYYDVTDISLGTSPVSLKEKDCPGGTRRPVKVGGEAYDAVCVTQQPRGFAHFGNSWDVGEENGRDDSAQGDDLVVYTIHSAGYYYYITQWNFSDDGTITAKEGATGNLSPGDFDASDKQGWPIGKESRDRATSHQHNIFWRLDFQTDSSRPARIQQYDTNRSGTGEGGYPAQETTRKNVTKETSGNSDQHRWWRVSGTAGKNGDGHTRSWELVHSNSARYTGRKFTSKDVYFTQYKKCEKFPNHNRRWDSTCAKDIVAATDGEQLKHPIVWVNVGFHHIARDEDQTPMPVHWQGFQLSPRDVTDMSPLTPDRLRKPQYNGDPFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0P6</accession>
    <name>A0A0F7N0P6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AOC_like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_00640</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH80919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014285.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH80919">
        <property type="protein sequence ID" value="AKH80919"/>
        <property type="gene ID" value="AA958_00640"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_00640"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.148"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.480.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044859">
        <property type="entry name" value="Allene_oxi_cyc_Dirigent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041013">
        <property type="entry name" value="AOC-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18678">
        <property type="entry name" value="AOC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002518998" description="AOC_like domain-containing protein" evidence="1">
        <location>
            <begin position="32"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="AOC_like" evidence="2">
        <location>
            <begin position="47"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH80919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="168" mass="17617" checksum="CEE16291884CEFCA" modified="2015-07-22" version="1">MRPTEIPSRLTAAGAAAIVLTVPIGASQAHAADTHKAECMTISFIEQLVTTETKDAAPVGPSVGDVVITEDAVLDDQRNRIGTNDIKGIIIKKDAETGELYSFSASEYTLDDGTIHVAGLVNLTQLAAGKEQKLPAYGTGGRYAGKVGELTWTLVSETESLNSIALCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0X9</accession>
    <name>A0A0F7N0X9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">von Willebrand factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_01505</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014423.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_01505"/>
    <dbReference type="EnsemblBacteria" id="AKH81058">
        <property type="protein sequence ID" value="AKH81058"/>
        <property type="gene ID" value="AA958_01505"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_01505"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.330"/>
    <dbReference type="OrthoDB" id="514542at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519666" evidence="1">
        <location>
            <begin position="29"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="364"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH81058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="573" mass="59581" checksum="BAA957C835014B07" modified="2015-07-22" version="1">MLRRSVRGRTVVIATALVLAIGAGAVVAVQTGLLPQDDPCAGADLELAVVASPDIAPVVRRTAQRARATGVKTDGRCLDVEVSARPAAEVAQALRGKDTRPGFQVWIPDSSIWTGMVTAGGGGASIDEVTRLASSPVGMATLQDGARKLGWPEKTYGWAELTDAALGDGAGLRLGTADPAVSATGALALTAMHRAGGKDADTRTAATAKLLSERVEPGDAAVLASLPDSGLDDPKDNDALFLSEQAAFRHNAGASTGGRLDMFYPEGGTVALDYPYTIVDNDAMAMDRVRAASRFQRLLTDGKTTDQLRRQGFRAPDGRLDADLAMAAGGAAPQPFDAPPAEAPAPDEVASVLGMWTVTVQSARLTTVVDVSGSMGELVPGEAGQTRMDVTKNALIQALSQFTGEDEIGLWRFSTRLEGEQDYEEVTGTTRLAQRTDDGASHRELLASAFGSLQPVPDGATGLYDTALAAYERQVKEYAPGRFNAVVLLTDGTNEDPGSISAADLAARLRKTADPERPVGLIAIGIGPDADIEACGRIAEAVGGESYRVTDPKEIHAVLLRAVTDAGAKAALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N111</accession>
    <name>A0A0F7N111_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_01480</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014419.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_01480"/>
    <dbReference type="EnsemblBacteria" id="AKH81054">
        <property type="protein sequence ID" value="AKH81054"/>
        <property type="gene ID" value="AA958_01480"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_01480"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.325"/>
    <dbReference type="OrthoDB" id="1515911at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="150"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="226"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="282"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="3">
        <location>
            <begin position="10"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="3">
        <location>
            <begin position="151"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH81054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="349" mass="35718" checksum="341114988490D63C" modified="2015-07-22" version="1">MQQSFDRRAGLGLALASALAFGGSGVAAKPLIEQGVDSLHVVWLRIAGAALVLLPLAWRHRALVRERPALLAGFGVLAVAGVQAFYFAAIARIPVGVGLLIEFFGPALVLGWVRFVQRRPVTRQAAVGVLFAVTGLACVVEVWAGLGFDALGLLLAFGAACCQCAYFVLAGHGTDSADGKAPNPLGVIAYGLIVGAVVLTLVSRPWNLEWSLLGERAELGGMRPPAWTLIVWIVLVTTVLAYLFGVLAVRRLSPPVAGVVACLEAVVASVLAWVLLSEHLGAAQIVGGALVLIGAFTAQLAAPAPGPGERGEPVAGNVPRPREGGEEPSGGAPAASAADAPPPGQSAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N1R1</accession>
    <name>A0A0F7N1R1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_10135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015867.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH82525">
        <property type="protein sequence ID" value="AKH82525"/>
        <property type="gene ID" value="AA958_10135"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_10135"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2134"/>
    <dbReference type="OrthoDB" id="1744037at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="11"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="189" mass="20763" checksum="5C38E7C5F87B5153" modified="2015-07-22" version="1">MNDVRWLSEDEQRIWRLFMDAVRDFNAHLDRQLRRDSGMPVAYYEILVHLSEAPGRSLRMSQLAELCRSSRSRLSHAVAALEKAGYVSRCTTDADRRGSVAQLTDAGFGVLEAAAPAHVTEVRKHLFDVLTPEQQQQLGEISGAVKNGLRPICAQARAEDGEEAEEAEVTMEATAEGAAGKAREAVAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N1T5</accession>
    <name>A0A0F7N1T5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Peptidase S1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AA958_03450</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014751.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_03450"/>
    <dbReference type="EnsemblBacteria" id="AKH81393">
        <property type="protein sequence ID" value="AKH81393"/>
        <property type="gene ID" value="AA958_03450"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_03450"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.729"/>
    <dbReference type="OrthoDB" id="1110723at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037295">
        <property type="entry name" value="Alpha-lytic_protease_prodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004236">
        <property type="entry name" value="Pept_S1_alpha_lytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001316">
        <property type="entry name" value="Pept_S1A_streptogrisin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035070">
        <property type="entry name" value="Streptogrisin_prodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02983">
        <property type="entry name" value="Pro_Al_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001134">
        <property type="entry name" value="Streptogrisin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00861">
        <property type="entry name" value="ALYTICPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54806">
        <property type="entry name" value="SSF54806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519164" evidence="7">
        <location>
            <begin position="26"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="Pro_Al_protease" evidence="9">
        <location>
            <begin position="119"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="8">
        <location>
            <begin position="241"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="334"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="208"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="291"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="328"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001134-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001134-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AKH81393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="380" mass="39207" checksum="98C9B861288C51DF" modified="2015-07-22" version="1">MRRTFGLRLGLSALLLLSTWGGAAALAPAAGADSARELSPGLARALQRDLGLTADQARERLADERRAGETEKKAERAAGAAYGGSWFDADSGRLTVALTGTRRADAVRATGADVRVVEHSAARLDATMKRLDALSAPAGVASWHVDARANSVRVDVVAGHRGDAPVRAFLERARAAGPVEVGTVAEAPSTFAAGTVGGDPYYTGNVRCSIGFSVHGGFVTAGHCGGAGQAVSGWDRSYIGNFQGSSFPDNDYAWVNVGSGWWTVPVVLGWGTVPDQLVRGSAEAPVGASICRSGSTTRWHCGTLLAKNETVNYSGGAVVRQLTKTSVCAEPGDSGGSFISGDQAQGVTSGGWGNCSGGGETWYQPVNEILGRYGLTLHTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2C2</accession>
    <name>A0A0F7N2C2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">N-acetylmuramoyl-L-alanine amidase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_11450</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016081.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_11450"/>
    <dbReference type="EnsemblBacteria" id="AKH82745">
        <property type="protein sequence ID" value="AKH82745"/>
        <property type="gene ID" value="AA958_11450"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_11450"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2410"/>
    <dbReference type="OrthoDB" id="1584918at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06583">
        <property type="entry name" value="PGRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036505">
        <property type="entry name" value="Amidase/PGRP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002502">
        <property type="entry name" value="Amidase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015510">
        <property type="entry name" value="PGRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006619">
        <property type="entry name" value="PGRP_domain_met/bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11022">
        <property type="entry name" value="PTHR11022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01510">
        <property type="entry name" value="Amidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00644">
        <property type="entry name" value="Ami_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00701">
        <property type="entry name" value="PGRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55846">
        <property type="entry name" value="SSF55846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002518983" evidence="3">
        <location>
            <begin position="25"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="PGRP" evidence="5">
        <location>
            <begin position="250"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetylmuramoyl-L-alanine amidase" evidence="4">
        <location>
            <begin position="263"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="36"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="101"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH82745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="445" mass="45126" checksum="A2E543DEA35ED5C2" modified="2015-07-22" version="1">MYVFSSSVVAVSAAALLAPLTPLAAPPASAGALPRAAEAERAAGRTQSLPLAPLGSSSRGPGAGTMGLSKPDAGPFTMVGVVWKDPEAELDGRARVRARSAETGRWSGWQDLDPHAADAPDPGSGAEPGGEAGAGAGGGAAARRGGTAPLWVGESTGVEVRVVPARSRSADAAGAAGAAEAVGAAGLPRGLTAELIDPGGAGAGTGKARAAGTAAAGELAAQTKAASEADAVRLNPALPAAVGPFVGPRPEIVTRKGWGADESRRAKGYRYTKTVNIAFVHHSATGNDYRCTEAPGLVRGIYRYHTQSLNWADVGYNFLVDKCGRVYEGRAGGVTRAVMGAHTYGFNHNSMGIAVLGSYDSAVPSQAAVNAVSRLTAWKLGLFGKDPEGKQTKVSGGGKYARGTRVRMNVISGHRDGFATACPGVRLYDRLGATRASSASYQGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2N1</accession>
    <name>A0A0F7N2N1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peroxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_08490</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DyP-type peroxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015614.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_08490"/>
    <dbReference type="EnsemblBacteria" id="AKH82266">
        <property type="protein sequence ID" value="AKH82266"/>
        <property type="gene ID" value="AA958_08490"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_08490"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1792"/>
    <dbReference type="OrthoDB" id="837319at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006314">
        <property type="entry name" value="Dyp_peroxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04261">
        <property type="entry name" value="Dyp_perox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01413">
        <property type="entry name" value="Dyp_perox_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51404">
        <property type="entry name" value="DYP_PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 5" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="322"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH82266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="350" mass="36862" checksum="81B0BBEA62DF9EF9" modified="2015-07-22" version="1">MPEPQPVLAPPATAAVFLVVTVAPGGEDTIRDVLEDLPARQRAVGFGAPDDDLTCVAGIGAAVWGRLFQGPRPAGLHPFRELEGERHRAVATPGDVLFHIRSRRMDLCFELARRLRARLGDAVAVADEVHGFTYYDMRDLLGFVDGTENPVGRAAGAAVFTGPEDPRFAGGSYVMVQKYVHDLDAWEALSTEEQERVIGRTKLGNTELPEGVQPEDPHVALNTITGPGGEERQVVRDNMPFGSVGDGEFGTYVIGYARAPGVLEEMLENMFLGRPPGTYDRILDLSTAVTGCLFFAPAAGFLDDLPALPAALGAAAAAVPDPVAPGPVPDPQGAGDGPLGIGGLKGAPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2P4</accession>
    <name>A0A0F7N2P4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RNA polymerase sigma 70</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AA958_08630</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Interacts transiently with the RNA polymerase catalytic core formed by RpoA, RpoB, RpoC and RpoZ (2 alpha, 1 beta, 1 beta' and 1 omega subunit) to form the RNA polymerase holoenzyme that can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015634.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH82286">
        <property type="protein sequence ID" value="AKH82286"/>
        <property type="gene ID" value="AA958_08630"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_08630"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1820"/>
    <dbReference type="OrthoDB" id="1914729at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="7">
        <location>
            <begin position="11"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="8">
        <location>
            <begin position="111"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH82286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="290" mass="31710" checksum="FAD5DD6A6CCCB831" modified="2015-07-22" version="1">MNAQQLQAELFEVRRPRLQAIAYRMLGSSGDAEDAVQEAWLRLCRADTDQVRNLDAWLTTVVTRVCLSMLRARQSRREDLTDEQVHEPERDRREAPDPEREALLTDSVGLALIVLLDTLGPAERLSFVLHDLFDVPFDEIGRIIERSPGAARQLASRARRRIQGAATPPAADAKRSREVVSAFLLASRGGDFEALLGVLDPDVVLRADTPAVRLGAPEEAFGSVAAGRFLFGRAGGAKLALVDGAVGAVWIRDDRPLVVFRFGIVGGLITSIGLTAERSRIDGLKLEVLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2Q7</accession>
    <name>A0A0F7N2Q7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tripartite tricarboxylate transporter TctA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_01895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
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                <person name="Heide L."/>
                <person name="Kaysser L."/>
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            <dbReference type="EMBL" id="AKH81127.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
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</entry>
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">CNQ-509</strain>
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            <begin position="4"/>
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        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AKH82316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="114" mass="12425" checksum="245268C75A3F2A6B" modified="2015-07-22" version="1">MGEIDELRRRLDALEAQVHELTEQQAATRHLAVNSDRDVAALQEQRRADIQLLQSLRQTQLEQGKILEAHSKALEAHGKTLLEHSQVLGVLVSGQVAIMEHLGINPPEAAAGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N365</accession>
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    <protein>
        <submittedName>
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    </gene>
    <organism evidence="3 4">
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        <lineage>
            <taxon>Bacteria</taxon>
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        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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    </dbReference>
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            <begin position="1"/>
            <end position="15"/>
        </location>
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        <location>
            <begin position="63"/>
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            <begin position="143"/>
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        </location>
    </feature>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH82446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="367" mass="37661" checksum="ADAE628544876572" modified="2015-07-22" version="1">MSHNQPPPPGPYGGGGQQPGPYGQPGPYGQPQQPQQPAQSPYAQPGQGGQPGQPGYGYPQQGGDQGYGQQQQQPGGYGQPGGYGQQQYGQQQAGPYGQQQPGYGQAPPSPPPGGGKNKTLFVVVGAVVAVALIAVAAFFLIGGDDDDGKKDESKNSQNDGDKTDDGSDSGDDPPADDGKKYKLTTPETVASEYQKDDSAPGGGLNSSDIDQLETIGVSNPKDVGAGYTAGTEATAKILQFQGVYGDISNPDMVLDAFFTYMAKEAAADPSAGGGDTAELVGSPEEVNPDGLEEGASMKCQYVKFSSDDSGAPVDSFNFPTCAWADSSTIGYIAMTDPTLIITGGETSIDEAATTTAEVRNDVRVPLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N382</accession>
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    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
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    </protein>
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        <name evidence="5" type="ORF">AA958_05940</name>
    </gene>
    <organism evidence="5 6">
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        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
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        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH81818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="224" mass="24544" checksum="548DAF1A14E4E4D3" modified="2015-07-22" version="1">MSAPETPETPEDVVAASAGGGEHVPPLTTRVVIAEDEALIRLDLKEMLEEEGYTVVGEAGDGETAVRLAREHQPDLVILDVKMPVLDGISAAEQIAADSIAPVLMLTAFSQRELVERARDAGAMAYLVKPFSKGDVVPAIEMAVSRYTELKTLEKEVVDLTQRLETRKLVDRAKSILQTEYGLSEPAAFRWIQKTSMDRRLSMQQVAEAVIEDDAEKKAKKKQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3K2</accession>
    <name>A0A0F7N3K2_9ACTN</name>
    <protein>
        <submittedName>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_03350</name>
    </gene>
    <organism evidence="3 4">
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        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014736.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_03350"/>
    <dbReference type="EnsemblBacteria" id="AKH81377">
        <property type="protein sequence ID" value="AKH81377"/>
        <property type="gene ID" value="AA958_03350"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_03350"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.712"/>
    <dbReference type="OrthoDB" id="1024978at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="2">
        <location>
            <begin position="23"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH81377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="484" mass="50011" checksum="733056D644F3ACBE" modified="2015-07-22" version="1">MDTDDVRASELVAALGRWSAGRGPLYVLLAARLRRLVDEGRLRPGAALPPERALATALAVGRTTVVAAYGVLRQEGRVVRRQGSGTRVAEAALVPGRTAETANPLFLNLLEPADGVILLSCAAPDGPPPELARAYRDLALPATGLGYHPAGLPALRAAVAARYAARGIPTDPAQILVTTGGQQALALLTRLFVAPGDPVLVEAPAYPGALDLFREAGAVLRPVAVGPHGIDVDAAVRTLAEHRPALAYVGSVYQNPTAAVLPPLRGRRLAEAAGHFGVPLVDDEVVADLALEGAAPPALAAGADSAEVISVGSLSKVVWGGLRIGWVRAPAGVVTRLARLKAVHDLGTDVPAQLVAVSLLAAYEPLLARRRAELRAAHGHLRAELARLLPSWVCPPVPGGQTVWVRLPYGDGVSFAQVALRHGVAVLPGACVDAAGGSGPYLRLHFCSPRDVLTDAVERLAAAWTAYDGSCRPATPAALGGVTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3K5</accession>
    <name>A0A0F7N3K5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_14600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016570.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH83255">
        <property type="protein sequence ID" value="AKH83255"/>
        <property type="gene ID" value="AA958_14600"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_14600"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3075"/>
    <dbReference type="OrthoDB" id="2047691at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007061">
        <property type="entry name" value="DUF664"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04978">
        <property type="entry name" value="DUF664"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="187" mass="20933" checksum="B1B3B60D26E12091" modified="2015-07-22" version="1">MSDDDAPQRWTEASVYPDMWADPDKDPRNNDSSPDGELATLQDFLVNYRLTLQMKCEGLTAEQLARRSVPPSTMSLLGLIRHLAEVERDWRNWVVPENPAPKIYGERDADFHGAAADQALVDAAFADLAREQAECDAVLGAYTDLGARLPKDGTSVRELWVHRVEEYARHCGHADLLRECVDGRVGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N410</accession>
    <name>A0A0F7N410_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Universal stress protein UspA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_07590</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015468.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH82118">
        <property type="protein sequence ID" value="AKH82118"/>
        <property type="gene ID" value="AA958_07590"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_07590"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1592"/>
    <dbReference type="OrthoDB" id="2040681at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="3"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="149"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH82118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="293" mass="30095" checksum="0D97808A18F738ED" modified="2015-07-22" version="1">MSGVVIVGVDGSAPSLVAVDAAAREARWRSAGLRIVHAFRWPPNRVPMGPPVPPPDEREIREMAGSLVTEAVDRARAVAPSVDVTNAVVTGEPLTVLEGQSRAGELVVVGSRGIGGFAGLLAGSTAVHLAAHGRCPVLVVRGRPEPAGPIVLGADGSPAGVAAVDFAFAEAALRGVSVLALHAWTTWNAPVPPPQDPAVAYASRPGMLAEAEERLLCEALAGHRERYPDVPVELRVVHGPTREALIEASSTAQLLVVGARGRGGFAGLLLGSVSQAVLHHAHCPVAVVRSGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N497</accession>
    <name>A0A0F7N497_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TetR_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_08065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH82194">
        <property type="protein sequence ID" value="AKH82194"/>
        <property type="gene ID" value="AA958_08065"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_08065"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1701"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011075">
        <property type="entry name" value="TetR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16859">
        <property type="entry name" value="TetR_C_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TetR_C" evidence="1">
        <location>
            <begin position="55"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="178" mass="19300" checksum="8599F0FA8559803A" modified="2015-07-22" version="1">MVKLCRERVYEDIQPADVAKLAGHDEQQLRAIWPTKSLMVVEALFGEVAPRLVFPDTGDFEADLRSQLTSIAEAFGDPGVGPHIAALAAEANTDRMLAKVFLDRVFTPNRAAASKRFRAAQEAGQVRRDLDLDAAIDMVFGPIWFRLLLGTGTLTAELGASLADHAVGGLASRPDRTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4A5</accession>
    <name>A0A0F7N4A5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tyrosine--tRNA ligase</fullName>
            <ecNumber evidence="7">6.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Tyrosyl-tRNA synthetase</fullName>
            <shortName evidence="7">TyrRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">tyrS</name>
        <name evidence="10" type="ORF">AA958_05140</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + H(+) + L-tyrosyl-tRNA(Tyr)</text>
            <dbReference type="Rhea" id="RHEA:10220"/>
            <dbReference type="Rhea" id="RHEA-COMP:9706"/>
            <dbReference type="Rhea" id="RHEA-COMP:9707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78536"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.1" evidence="7"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015037.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_05140"/>
    <dbReference type="EnsemblBacteria" id="AKH81682">
        <property type="protein sequence ID" value="AKH81682"/>
        <property type="gene ID" value="AA958_05140"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_05140"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1080"/>
    <dbReference type="OrthoDB" id="402899at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
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</entry>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH82453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="846" mass="84045" checksum="C0827584A073C499" modified="2015-07-22" version="1">MSDGPAGARARTNGLARAALRFRPAGFAGTFVALMMAALIVSACGILLETGVRASVPPERYAHVPVVVAADQRAHMTVGSGDGAYDASEQVPDRARVGAGLAERVASARGVAAAVPDVTFPARLAAGEGAPGGAALTAQGWGSHAFTGTSLAEGSAPGADEVVLDRATARAAGADVGDTIALVLPSGQQEFRVSGIAAAAAARTSGAAYLADAAAARAAGHPGRFDAVAVLAADGAGAGQLADAVRGAVGDRAEVHTGDGRGGVEDTGVAAAEELLTGLGGSFGGIAATVAVFTAAGTVALSVAQRKREFALLRAIGATPRQIRRSVAAEALLVAPAAGLAGLLPGIGLASWWFGQLKDRDAVPAAVDLHVSPIPLAVAVGTALLSALVAGWAAARRPARTKPGQALTEASVERLRPGIVRTVLGLGAVTGGILLSGVAARSAGDDAAEAALGVVMLFMLAVALLGPLIARLAAGLFGLPLRAGDASAELAAANSRTNARRLASAITPIVLATAFASVLVFMHTSEDHATAAQQRAGVTADHVVTHPGGLPADAAERAARQPGVEAAVGVLRSEVLVPVGGGGDRWLQGATAQGVSGDGLTRVQDLDVRQGSLDRLPEPGTVALDENLARSAGAGVGERVELRLPDGTPEKAEVVATYGRGLGLAQVTLDRAALAGHVTAGYDTDLLVSGGSAAGLGALGGAGTAVTDAAGYAQQQDVDRSLNRWANFTMAGVLGGFAAVAALNTLVMTVLDRRRELGMLRLIGSTRRQVLGMIRWEGLLVGVAGLVLGGAIAAATLVPMVRGITGGDPYLPPLTVAAFTAGAVGLGLLGTVLPARAALRRAEPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N568</accession>
    <name>A0A0F7N568_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Resolvase/invertase-type recombinase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_13920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016479.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH83151">
        <property type="protein sequence ID" value="AKH83151"/>
        <property type="gene ID" value="AA958_13920"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_13920"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2930"/>
    <dbReference type="OrthoDB" id="1791095at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006119">
        <property type="entry name" value="Resolv_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036162">
        <property type="entry name" value="Resolvase-like_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00239">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53041">
        <property type="entry name" value="SSF53041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Resolvase/invertase-type recombinase catalytic" evidence="1">
        <location>
            <begin position="14"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="138" mass="15328" checksum="85825C562E4B115E" modified="2015-07-22" version="1">MDTPAPPTRPTLAFLYDRHATLATAALDERIARCRRYAAERGWVVAGEWVDRGDHALTNWPRPQWDAMTYAMRQAAARAVCLVDSWDRISRDREGSAILRLGVHQAGGYCMTTGGEDDLGPGRGRITVTAPLPRRARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N597</accession>
    <name>A0A0F7N597_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">C1 regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_10500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015925.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_10500"/>
    <dbReference type="EnsemblBacteria" id="AKH82583">
        <property type="protein sequence ID" value="AKH82583"/>
        <property type="gene ID" value="AA958_10500"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_10500"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2212"/>
    <dbReference type="OrthoDB" id="1012960at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="432" mass="45791" checksum="904603A801CB3E0D" modified="2015-07-22" version="1">MRPNAAFRALRGSRSPGEFAASVRRAAREIGEQVSCDARYVGRVESGEIRCPNYAYERVFLHMFPGRSLGDLGFEPRAAVRGRRARGGKDAPPRTSMRPTPPEGPAEHSPAASAAGGPPPLPPFPALPPARPRTPEFAEAAVAEAVRRIRLHDDRHGADDLYARACCTLRTARALLPETVPRPGSDAERLHAAAGELALSVGWLAHDSGRYADARSHYAEALATARLADDPALEAHAFSNTAFLARDTGRAHEAVRAAQAGRRAAAAAGCDRLRSLLAVREAGGWALLGDPAATREALTTAGDLFARGAADGCPEWMSFYGEAELTGLEAQCWAALGDHTRAAECARRAVLLQDPHFARNTALFTAELAADLAAAGRPDEAAAAAGGALALLEEVRSARVRAMLDATAERLRRWSGRSEVDAFLTNPGLISA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5C2</accession>
    <name>A0A0F7N5C2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex</fullName>
            <ecNumber evidence="4">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_06955</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="4"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015348.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_06955"/>
    <dbReference type="EnsemblBacteria" id="AKH81997">
        <property type="protein sequence ID" value="AKH81997"/>
        <property type="gene ID" value="AA958_06955"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_06955"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1454"/>
    <dbReference type="OrthoDB" id="1626282at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014276">
        <property type="entry name" value="2-oxoglutarate_DH_E2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="SSF47005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02927">
        <property type="entry name" value="SucB_Actino"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3 4" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="6">
        <location>
            <begin position="2"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="6">
        <location>
            <begin position="142"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="7">
        <location>
            <begin position="309"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="80"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="223"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="226"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH81997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="618" mass="61864" checksum="5AC59BF590DE4FBB" modified="2015-07-22" version="1">MAVSVTLPALGESVTEGTVTRWLKAEGESVEADEPLLEVSTDKVDTEIPSPAAGVLSSIKVAEDETVEIGAELAVIDDGTGGAEAAPAPAAEQAAAPQQPAPAAAPAPAPAQAPAQAEAAPAPAPAAPQEPAPAQAAGGAQGTDVTLPELGESVTEGTVTRWLKQVGEQVEADEPLLEISTDKVDTEIPSPASGTLLEIVVQEDETAEVGAKLAVIGSGAAAPAAPAAPAPAPAAPAPAPEAAAPAPAPAPAAAPAAPPPAPAQPAPPAQPAPPAPAAAPAPAAPAPAAAAPAPAAAAPAPAPAAEGAYVTPLVRKLAAESGVDLATVKGSGVGGRIRKQDVVAAAEQAARAAASAPAAATAAPSAGRPAAPVLEASPLRGQTVKMPRIRKLIGDNMMRALHEQAQLSTVVEVDVTRIMRMRARAKDAFAQREGVKLSPMPFFVKAAVQALKAHPVVNARINEDEGTISYFDTENVGIAVDTEKGLMTPVIKGAGDLNIAGIARKTAELADKVRNNKITPDEVSGATFTISNTGSRGALFDTIIVPPNQVAILGLGATVKRPTVVDHPELGETIAVRHMTYLTLSYDHRLVDGADAARYLGTVKGLLEAGEFESEIGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5D7</accession>
    <name>A0A0F7N5D7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransf_25 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_07085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015372.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_07085"/>
    <dbReference type="EnsemblBacteria" id="AKH82022">
        <property type="protein sequence ID" value="AKH82022"/>
        <property type="gene ID" value="AA958_07085"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_07085"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1485"/>
    <dbReference type="OrthoDB" id="1664438at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="48"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="279" mass="29524" checksum="5338E8ACBC9BCFB3" modified="2015-07-22" version="1">MAESARTLDWNGANGDHWVAYEEQYNAAMFRYSERLFAGADVQPDDRVLDVGCGCGQTTRVAAALAAEGSALGVDLSAAMLAQARARAAEEGVGNVRFEQADAQVHGFADGAYDVAISRHGVMFFADPVAAFANVRRALRPAGRLAFVCWRAPEESEYSAVPRAALGRYVTVPKSGGVNEPGPNSLADPDRVREVLGGAGFVDVRLEAENEPMDLGAGVGEALDFVLNRPHVRGVMADLDGGTKAKATEALREALTPYVTPEGVLLRAPAWLVTAHNAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5I8</accession>
    <name>A0A0F7N5I8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polyketide cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_11005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AHA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016007.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_11005"/>
    <dbReference type="EnsemblBacteria" id="AKH82669">
        <property type="protein sequence ID" value="AKH82669"/>
        <property type="gene ID" value="AA958_11005"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_11005"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2317"/>
    <dbReference type="OrthoDB" id="1914312at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013538">
        <property type="entry name" value="Activator_of_Hsp90_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08327">
        <property type="entry name" value="AHSA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="147" mass="16345" checksum="01120C7EC8A40214" modified="2015-07-22" version="1">MTDHPVKHSTFTLERTYAASPAAVFAAWSDRDTKAKWFAAQDDRYTLDFRVGGTEAVHGDDGTGLVARSEYHDIVPDERIVYTTALFTGEVLSTVSLTTVRFTRDGDGTSLVLTEQGTFLDDREQPEWREQGTGDWLDALGRQVAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5T6</accession>
    <name>A0A0F7N5T6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HATPase_c domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_15510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016693.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_15510"/>
    <dbReference type="EnsemblBacteria" id="AKH83381">
        <property type="protein sequence ID" value="AKH83381"/>
        <property type="gene ID" value="AA958_15510"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_15510"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3265"/>
    <dbReference type="OrthoDB" id="1832160at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HATPase_c" evidence="2">
        <location>
            <begin position="21"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH83381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="195" mass="19770" checksum="53CD03E69BE716C7" modified="2015-07-22" version="1">MVMFVVAQQAPASSMAVPHGPDGVGLARRRLRADLRARGTAEATVDDAVLVLSELLSNAYRHARPLATEAATADAEVLVRGRADPRPAGGPGQEPAPGADAAPAAQAAEEAPAAPGPGTADTRVRADWHIDPDGRVTVAVTDGGGPTRPLPATPSVTAKGGRGLAIITSLACDWGVRYDAGPLGEVTVWASLPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5W5</accession>
    <name>A0A0F7N5W5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Exopolyphosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_11715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016125.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_11715"/>
    <dbReference type="EnsemblBacteria" id="AKH82789">
        <property type="protein sequence ID" value="AKH82789"/>
        <property type="gene ID" value="AA958_11715"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_11715"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2463"/>
    <dbReference type="OrthoDB" id="1862004at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003695">
        <property type="entry name" value="Ppx_GppA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02541">
        <property type="entry name" value="Ppx-GppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ppx-GppA" evidence="1">
        <location>
            <begin position="23"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="308" mass="32550" checksum="481BB69706A6B0B2" modified="2015-07-22" version="1">MTRVAAVDCGTNSIRLLVADVDTRSGEVKDLDRRMEIVRLGQGVDRTGRLAPEALERTFAACRRYAEIIERLGAVRTRFVATSASRDAENRADFARGVEEILGVRPEVITGDEEAALAFTGATKELSGRVPGPYLVVDIGGGSTEFVAGTDDVAAARSVDIGCVRLTERHHFADPPTPAQIEAAKADIAAALDTAEAAVPLRDTATLVGLAGSVTTVAGIAMDLPAYDTMALHHARVPVARIRDITNSLLKATHEERAAIPVMHPGRVDVIAAGALVLLSVMERTGAPEVIVSEHDILDGIAYRCASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5X9</accession>
    <name>A0A0F7N5X9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Toxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_11810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016140.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_11810"/>
    <dbReference type="EnsemblBacteria" id="AKH82804">
        <property type="protein sequence ID" value="AKH82804"/>
        <property type="gene ID" value="AA958_11810"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_11810"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2482"/>
    <dbReference type="OrthoDB" id="1996962at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="27"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="81" mass="8696" checksum="CFA689BD7B9321AB" modified="2015-07-22" version="1">MNTSDLAWFKSSYSSPSGDNCIEVAVSWRKSTYSSTSSGDCVEVAACPSVVHVRDSKDKAGPRLAFTPDAWADFVAFARGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6J1</accession>
    <name>A0A0F7N6J1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein translocase subunit SecE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">secE</name>
        <name evidence="9" type="ORF">AA958_21015</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the SecE/SEC61-gamma family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_027771083.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_21015"/>
    <dbReference type="EnsemblBacteria" id="AKH84260">
        <property type="protein sequence ID" value="AKH84260"/>
        <property type="gene ID" value="AA958_21015"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_21015"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4426"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
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    <keyword evidence="1 7" id="KW-0813">Transport</keyword>
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    </evidence>
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        <source>
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        <source>
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        </source>
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        <source>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH84260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="90" mass="10150" checksum="C77A9B4D7FB33134" modified="2015-07-22" version="1">MTEASTATPDRPEGDARPARRGGKRGRKGPFARLALFYRQIVAELRKVVWPTRNQLTTYTTVVIIFVVVMIGIVTVIDFGFTELMQYVFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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            <dbReference type="EMBL" id="AKH83169.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
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    <sequence length="150" mass="16540" checksum="8B61628BF5DEB864" modified="2015-07-22" version="1">MSETWEPTGAGVMRLPSGRYVRGRGLRKPAPAGPDPDLGVYLLGRPAPETAWESRWVRWPDFRLPADRGAAEAALREAWERAERERVEVACGGGVGRTGTALACLAVLDGVPAGRAVAYVREHYNRRAVETPWQRRYVSRFPEGRGASAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
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        <submittedName>
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        </submittedName>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
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        </location>
    </feature>
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        <location>
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            <end position="412"/>
        </location>
    </feature>
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            <dbReference type="EMBL" id="AKH84375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="562" mass="59457" checksum="990EB77CE67AE869" modified="2015-07-22" version="1">MTVGTQVFEGWGELVGAAVVGGGRRGVDEGALLDAAAAATVRRRAGVVPAPARRLPECAAHDPRPRLPSAARRRLAALLADRSGTGGGTRRRGPTPDLAELIPEWLRHAVEYGYQAPPELLPALLDAARARIDLRPHALALAGPRGLWLAERAPQWAPLLRDGAAGPALPDPRDAGAVRALWEEGPRTGGPATGQVRGALFAEVRRADPAGAVELLTTTWSAEKAEDRLAFVELLRTGLSLSDERFLEDALADRSRGVRAAAAELLAGLPGSALAGRMAARVRSLVMLDRSEEPPVVAVEAPYECDAAMERDGIVATPPAGMGERSWWFGQLVAAAPLAVWTEVFDDRTPAEVVELPVADGWRPDLLAAWSRAAARQHDAAWARALLCTAPTSPPNEPPPFTAGPPSPARIPAPGSTSGGGEHVPGRDPARLLTALPEAERAAWVAEFISAHGLSEAFRLLGACAVPWPEELGRAVVDALEIARDGGSYPWSFSGVMGLAERCLDPSYAVRLEPLAAMHEEAEESSPGAAGYWSEAFQRLVATLRIRAAMRDELTTPAALRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N771</accession>
    <name>A0A0F7N771_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="2 3">
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        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF11238">
        <property type="entry name" value="DUF3039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="99" mass="10469" checksum="508D0B35A0455339" modified="2015-07-22" version="1">MSTPLPEPERGTGTGTLVEPTPEVSHGDGDHERFAHYVQKDKIMASALDGTPVVALCGKVWVPGRDPKKYPVCPMCKEIYESMGAGGGKDGGKDGGKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N797</accession>
    <name>A0A0F7N797_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA polymerase subunit sigma-24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_14670</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH83264">
        <property type="protein sequence ID" value="AKH83264"/>
        <property type="gene ID" value="AA958_14670"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_14670"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3090"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014325">
        <property type="entry name" value="RNA_pol_sigma-E_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02983">
        <property type="entry name" value="SigE-fam_strep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="5">
        <location>
            <begin position="14"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="6">
        <location>
            <begin position="105"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH83264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="166" mass="18465" checksum="AE7A8553A22A21A0" modified="2015-07-22" version="1">MAEGTSVDHLTETYQTHYRSLLGLAALLLDDLASCEDVVQEAFIRVHSARKRVKDPDKTLAYLRQTVVNLSRSALRRRITGLKLLSKPMPDMASAEEGAYEQLERDQLIQAMRGLQRRQREVLVLRYFADMTEAQVAESLGISLGSVKAYGSRGIAALRTAMGARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7Y1</accession>
    <name>A0A0F7N7Y1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RNA polymerase sigma factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AA958_20295</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Interacts transiently with the RNA polymerase catalytic core formed by RpoA, RpoB, RpoC and RpoZ (2 alpha, 1 beta, 1 beta' and 1 omega subunit) to form the RNA polymerase holoenzyme that can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017425.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH84136">
        <property type="protein sequence ID" value="AKH84136"/>
        <property type="gene ID" value="AA958_20295"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_20295"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4274"/>
    <dbReference type="OrthoDB" id="1914729at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014305">
        <property type="entry name" value="RNA_pol_sigma-G_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000838">
        <property type="entry name" value="RNA_pol_sigma70_ECF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02960">
        <property type="entry name" value="SigX5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01063">
        <property type="entry name" value="SIGMA70_ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="5 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="8">
        <location>
            <begin position="17"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="9">
        <location>
            <begin position="136"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="SnoaL-like" evidence="10">
        <location>
            <begin position="211"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AKH84136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="333" mass="36733" checksum="42430E37F17E463C" modified="2015-07-22" version="1">MATVNTAAEEDFLRLSDPYRRELLAHCYRMLGSVHDAEDLVQETYLRAWRSYGNFEGRSSLRTWLHTIATRACLTALERRQRRPLPTGLGGPGDDPAGELTERPEVPWLEPVPDVLVEPSEADPAAVVGSRESVRLAFVAALQHLPPRQRTVLLLRDVLRWKATEVAELLDTSTASVDSALQRARAQLEKAAPSEESVAEPADAARRELLDRYVEAFVTKDVREIVRLFTEDVVWEMPPVPEWFRGPDRVATLVSVQCPYAPGEARLLPVGLNGQPGYALYTRGPDGDHHPFALHVLTVAPGGDAISHVGCFFDTSLFATAGLPAVLSGEESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N808</accession>
    <name>A0A0F7N808_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AA958_16505</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016849.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_16505"/>
    <dbReference type="EnsemblBacteria" id="AKH83544">
        <property type="protein sequence ID" value="AKH83544"/>
        <property type="gene ID" value="AA958_16505"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_16505"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3473"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005543">
        <property type="entry name" value="PASTA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03793">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="389"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="20"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="316"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="418"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="325"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="346"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="424"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="454"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AKH83544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="551" mass="59108" checksum="29DC8AC454CA8C16" modified="2015-07-22" version="1">MTEYGGQDDYAGRSVGGGRYRLLDLLGTGGMASVHLAHDTVLDRQVAVKTLHTELGREDSFRERFRREAQAVARLSHQNVVSVFDTGEDRFAGDGGGPVPYIVMEYVEGRPLRSVLDEDVAQFGAMPTEKALRIVSDVLAALDASHEMGLVHRDIKPGNVMMTRREQVKVMDFGIARAVQSGVTSMTQTGMVVGTPQYLSPEQALGRGVDARSDLYSVGVMLFELLTGRLPFDADSPLAIAYAHVQEPPPAPSSINMTVPPVVDALVARALAKNPDERFRSAEEMREEVRRAGGMTPPGAMPSVVAGAHARDSGAGIGSAVFPPVNPYHSPPPGAPTPYQPMQQQGFGPPQPQQQQPHGGYATPQPYSLSPQGGPGGGHGGGKGNRNAAVIGLTVVIAMVVIAATAIILVLNGGDDGDPEAKPTGQTEQPNSDPTAGTGDDSGGEGDAGGKGDNEMIPPDRSRTIDKTRCTEPMTDPQNEKLVRVPDFTFKDYQSVRECLRAAQWSYEVDEEPDELWGKDTVLEQNFDEYDDYFDPSKDKLELVIATGYKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8T4</accession>
    <name>A0A0F7N8T4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_25085</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018191.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_25085"/>
    <dbReference type="EnsemblBacteria" id="AKH84940">
        <property type="protein sequence ID" value="AKH84940"/>
        <property type="gene ID" value="AA958_25085"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_25085"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5287"/>
    <dbReference type="OrthoDB" id="1936024at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046096">
        <property type="entry name" value="DUF6114"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19609">
        <property type="entry name" value="DUF6114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH84940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="180" mass="18385" checksum="EE6F5AE4A80C42F1" modified="2015-07-22" version="1">MSAELPDLLHRLNTWRLGFRGWRGSRPFWAGLLTIAGGVPIGALPYYNIKLGNLSLQMATQAGAGGLIIGVLLVTLGLTMWFHAVVRVFAGVASIVLALVSIPVSNFGGLLVGFLLSMIGGALAVSWVPGVPEAADDAGAADGAADDTGDGTAEEKRAGAGEPGVDVLEDIDGGRHRAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8T5</accession>
    <name>A0A0F7N8T5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_18880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017215.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH83918">
        <property type="protein sequence ID" value="AKH83918"/>
        <property type="gene ID" value="AA958_18880"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_18880"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3963"/>
    <dbReference type="OrthoDB" id="1775285at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH83918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="128" mass="13916" checksum="0B0743AAE642E025" modified="2015-07-22" version="1">MSRPTLYAERLADEITYQLGQLADRLSQLPPGQAARVIARILDPDPEEGVLGGITHLMVVSSVLAKDQSGRGALPPEVWLALGRASNELDDIGLDLDEHRETLHHAREQLAAADAKPAFAAPTARRHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9N1</accession>
    <name>A0A0F7N9N1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH_17 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_15670</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016719.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_15670"/>
    <dbReference type="EnsemblBacteria" id="AKH83407">
        <property type="protein sequence ID" value="AKH83407"/>
        <property type="gene ID" value="AA958_15670"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_15670"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3303"/>
    <dbReference type="OrthoDB" id="2076478at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010093">
        <property type="entry name" value="SinI_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01764">
        <property type="entry name" value="excise"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_17" evidence="2">
        <location>
            <begin position="28"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH83407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="83" mass="9182" checksum="9FA1E8BBCD9DF1FE" modified="2015-07-22" version="1">MRSSRAAESAAASSRTPSSSSERRPLASPEELSAYLGVPLGTLYSWNHRGIGPKATKVGRHLRYRWQEVEAWLDSRTTDHDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9P2</accession>
    <name>A0A0F7N9P2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_20940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017533.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_20940"/>
    <dbReference type="EnsemblBacteria" id="AKH84248">
        <property type="protein sequence ID" value="AKH84248"/>
        <property type="gene ID" value="AA958_20940"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_20940"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4412"/>
    <dbReference type="OrthoDB" id="1395441at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002909">
        <property type="entry name" value="IPT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01833">
        <property type="entry name" value="TIG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IPT/TIG" evidence="1">
        <location>
            <begin position="3"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="IPT/TIG" evidence="1">
        <location>
            <begin position="179"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="265" mass="25581" checksum="6F5DB4C3E6EC5CB6" modified="2015-07-22" version="1">MAPFITSISPTQGTAGTSVTITGTGFGALASTPVVHFGSTTVTGTVTVANTQVSVTAPGGCAGQVNVSVTVGSSTSNSRAFFYIAAPAVAALSANVGPDTSPPASTLYGSGLAAATAVTFGAAGAGTLGAVVSDSQRSATPPSFAVTGTPVTVDVTVTNPGGTSTITGAADQYTYYDQPTATTISPSTGSPGDTGVLITGTGFYEVSAVTFTDPAGPTDYPASFAATSDTQLIVTVPSGAPTATALDVTVTNPGGTTTPALVFNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9Q8</accession>
    <name>A0A0F7N9Q8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycoside hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_20575</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017471.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_20575"/>
    <dbReference type="EnsemblBacteria" id="AKH84184">
        <property type="protein sequence ID" value="AKH84184"/>
        <property type="gene ID" value="AA958_20575"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_20575"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4340"/>
    <dbReference type="OrthoDB" id="682655at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NlpC/P60" evidence="3">
        <location>
            <begin position="131"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="73"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="10"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="73"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH84184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="248" mass="24952" checksum="F12C88E24AB0089F" modified="2015-07-22" version="1">MVATAASAPALADTSRTTGSTATESTAALPTVDVSTALTTGVEQSADATQTAALRLELRTNAQEAAEDARKAAAKAKKEAEARAAAEERARERAAARAAEREELAAASAPDASTADSAPAAETPAAAPAASGSVGTVLDFLNAQVGKAYVLGATGPASYDCSGLTQAAFRTVGVELPRTAAEQSTVGTPVAVSDVQPGDLVFWGGTGSAYHVAVYIGDGKYLDAANPSKGVVIQEMSYYMPTSAVRVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9U3</accession>
    <name>A0A0F7N9U3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0336 protein AA958_20815</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_20815</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0336 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017515.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_20815"/>
    <dbReference type="EnsemblBacteria" id="AKH84229">
        <property type="protein sequence ID" value="AKH84229"/>
        <property type="gene ID" value="AA958_20815"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_20815"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4390"/>
    <dbReference type="OrthoDB" id="1380653at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00799">
        <property type="entry name" value="UPF0336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039569">
        <property type="entry name" value="MaoC-like_dehydrat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016709">
        <property type="entry name" value="UPF0336"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13452">
        <property type="entry name" value="MaoC_dehydrat_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018072">
        <property type="entry name" value="UCP018072"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MaoC_dehydrat_N" evidence="2">
        <location>
            <begin position="7"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH84229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="150" mass="16142" checksum="9A96BEA8726A2217" modified="2015-07-22" version="1">MPLDQSFVGRSYPPTAPYEVGREKIREFAEAVGDANPVYTDPDAAKALGHPDVIAPPTFVFAIAFRAAGQVIADPQLGLDYSRVVHGDQKFAYSRPVRAGDRLSVTSTIESIKSMAGNDIMDVRGEVRDEAGEHVVTTIIKLVARAAGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9W9</accession>
    <name>A0A0F7N9W9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioredoxin reductase</fullName>
            <ecNumber evidence="3">1.8.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_16155</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>[thioredoxin]-dithiol + NADP(+) = [thioredoxin]-disulfide + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:20345"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="4">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.9" evidence="3"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016795.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_16155"/>
    <dbReference type="EnsemblBacteria" id="AKH83487">
        <property type="protein sequence ID" value="AKH83487"/>
        <property type="gene ID" value="AA958_16155"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_16155"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3404"/>
    <dbReference type="OrthoDB" id="692968at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004791">
        <property type="term" value="F:thioredoxin-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019430">
        <property type="term" value="P:removal of superoxide radicals"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008255">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_2_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005982">
        <property type="entry name" value="Thioredox_Rdtase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01292">
        <property type="entry name" value="TRX_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00573">
        <property type="entry name" value="PYRIDINE_REDOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 3" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="5">
        <location>
            <begin position="6"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH83487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="325" mass="34568" checksum="62160C5F2ACE493D" modified="2015-07-22" version="1">MSDVRNVIIIGSGPAGYTAALYTARAALQPLVFEGAVTAGGALMNTTDVENFPGFRDGIMGPDLMDNMRAQAERFGAELVPDDVVSVDLTGDIKTVTDTAGTVHRARTVIVSTGSQHRKLGLPREDELSGRGISWCATCDGFFFREQDIVVVGGGDTAMEEATFLSRFAKSVTVVHRRDSLRASKAMQERAFADPKISFIWDSEVAAIQGGDKLSGLTLRNTKTGEESEIAVTGLFIAIGHDPRTELFKGQLELDGEGYLTVDAPSTRTNLPGVFASGDVVDHTYRQAITAAGTGCSSALDAERYLAAIADKEKSAEPEKVADAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9Y7</accession>
    <name>A0A0F7N9Y7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AA958_16340</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016822.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_16340"/>
    <dbReference type="EnsemblBacteria" id="AKH83517">
        <property type="protein sequence ID" value="AKH83517"/>
        <property type="gene ID" value="AA958_16340"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_16340"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3441"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005543">
        <property type="entry name" value="PASTA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03793">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00740">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51178">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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</entry>
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    <feature type="chain" id="PRO_5002519307" evidence="11">
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        <ligand>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AKH84394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="459" mass="47641" checksum="6DA98C45EA4C9EE8" modified="2015-07-22" version="1">MTIRGAALAAAATLLSLGGVAPAAAQDDKPRPPDQMSNVGGTLLGQPGTHVDLGSGAPELPKKLTGRSWVVADAESGAVLAAHNAHWKLPPASTLKMLFADTLLPLFNKEEKHKVAAEELEGMGAGSSLVGIKENLTYTVRELWLGVFLRSGNDAVHVLSAMNGGVDATVQAMNERARELGAEDTHVVSPDGYDAKGQTSSAYDLTLFARAGMQNPDFRAYAATPRAKFPGGKKGKKREYFEIQNTNRLLTGDVDVDVYKGIAGIKNGNTTNAGATFTGVAERDGRVLLVTVMHPDEGESNAVYKEAGKLLDWGFKAAPAVQPVGELVPPEGMRNEDAAGKDTDQGAEKNAGGTQGSGDEASASDGARPTAADGEEEGGVGTALAITIGSVALLAIVAYVIHRRWPLPDLVGRGRPGGAIEQEAGHEVDPDDERDGDAEGAVDAPSGDAAEVAAEKKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAL4</accession>
    <name>A0A0F7NAL4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_22445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH84499">
        <property type="protein sequence ID" value="AKH84499"/>
        <property type="gene ID" value="AA958_22445"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_22445"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="190" mass="19832" checksum="FE9F35510D8D5D91" modified="2015-07-22" version="1">MRQLVVTGRPVLPAQRQHPHGALRYEVRGVHRESVAVGAAVETVEVLADRAPVERHRVVAGPAAVPAGDLAAQLAEGAVVHGRVRQPVLADDLQRHALRGLGGVRGVAQQGEVGVGVHVDEAGGEDEAPGVEDGAAGEPRADGRDPAAGQPHVGAVSRRPRAVDDEGAADHQVHVCRSPVPLRRRSVRTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAM1</accession>
    <name>A0A0F7NAM1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Long-chain fatty acid--CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_28795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018813.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_28795"/>
    <dbReference type="EnsemblBacteria" id="AKH85580">
        <property type="protein sequence ID" value="AKH85580"/>
        <property type="gene ID" value="AA958_28795"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_28795"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6068"/>
    <dbReference type="OrthoDB" id="164380at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="23"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="607" mass="65491" checksum="8986605B51A2C879" modified="2015-07-22" version="1">MREFTVPPLADAPKSGGLADAVFQRAAQDPGQIAFARKVGGEWRDVTIGAFRDEVLALAKGLLAAGLRFGDRVGIMCRTRYEWTQLDFALWSIGAQAVPVYPTSAPDQAYWMLHDAGAVACVVESADHAMTVGSVIDKLPGLKLLWQIDEGAVEELSAAGAHLDDDVVERHRLAVTPDSPATVIYTSGTTGRPRGCELTHANFMAEADNILLRYEALFRPYEGEPAATLLFLPLAHVFGRMIQVTAVRGGVKLGHQPDPSAPVLLADLRTFRPSLILAVPHIFEKIYAAARRKAETEGRLAVFDKAADVAVRYAGAREDASFGAGRGPGPALRVEHQVFDKLVYAKMRAALGGRTRFVFSGGSAMQRRLGLFFAGAGITVIEGYGLTETTAAAVANPPERPRYGTVGIPIPGITVYIAPDDEVWLHGPQVFSGYIGDRPGAAHALRDGWLATGDLGSLDEDGYLTITGRKKELLVTSNGKSVSPVPLEERVRAHPLVSQCLAVGNDRPYVAALVTLDPDGVAHWQLMRGRPSMTPSELVRDGELEAEIRRAVVAANTQVSPPESIRAFRILAVQFTEEHGLVTPSLKLKRKAIEKAYANEVEALYQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAP2</accession>
    <name>A0A0F7NAP2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14 15">Dihydroxy-acid dehydratase</fullName>
            <shortName evidence="15">DAD</shortName>
            <ecNumber evidence="14 15">4.2.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">ilvD</name>
        <name evidence="16" type="ORF">AA958_17880</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(2R)-2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:24809"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:49072"/>
            <dbReference type="EC" id="4.2.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:24810"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>(2R,3R)-2,3-dihydroxy-3-methylpentanoate = (S)-3-methyl-2-oxopentanoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:27694"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:49258"/>
            <dbReference type="EC" id="4.2.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="15">Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="13 15">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 3/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12 15">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the IlvD/Edd family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.9" evidence="14 15"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017069.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_17880"/>
    <dbReference type="EnsemblBacteria" id="AKH83767">
        <property type="protein sequence ID" value="AKH83767"/>
        <property type="gene ID" value="AA958_17880"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_17880"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3766"/>
    <dbReference type="OrthoDB" id="193579at2"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00057"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00061"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004160">
        <property type="term" value="F:dihydroxy-acid dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00012">
        <property type="entry name" value="IlvD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042096">
        <property type="entry name" value="Dihydro-acid_dehy_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004404">
        <property type="entry name" value="DihydroxyA_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000581">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020558">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037237">
        <property type="entry name" value="IlvD/EDD_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00920">
        <property type="entry name" value="ILVD_EDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143975">
        <property type="entry name" value="SSF143975"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00110">
        <property type="entry name" value="ilvD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00886">
        <property type="entry name" value="ILVD_EDD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00887">
        <property type="entry name" value="ILVD_EDD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 15" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3 15" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 15" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="7 15" id="KW-0408">Iron</keyword>
    <keyword evidence="8 15" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 15 16" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="15">
        <location>
            <position position="522"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" description="via carbamate group" evidence="15">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="496"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="15">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AKH83767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="617" mass="64550" checksum="8B5CA1088800160C" modified="2015-07-22" version="1">MPALRSRTVTHGRNMAGARALMRASGVANEDIGKPVVAVANSFTEFVPGHTHLAPVGRIVSEAVKAAGAVPREFDTIAVDDGIAMGHGGMLYSLPSRDLIADSVEYMVEAHCADALVCISNCDKITPGMLMAALRLNIPTVFVSGGPMEAGRATLVDGTVRKLDLIDAMVDAANDGVSDADVLRIEENACPTCGSCSGMFTANSMNCLTEAMGLSLPGNGSVLATHTARKALYEAAGRTVVELTTRYYEQDDETVLPRNVASRSAFENAMALDIAMGGSTNTILHLLAAAQEAGLDYGLADIDAVSRRVPCLAKVAPNVAPGGTYYMEDVHRAGGIPAILGELYRAGLLNEDVHAVHSDSLADWLKRWDVRGGSPSPEAVELWHAAPGCVRSATAFSQSERWESLDTDAEGGCIRSLEHAYSKDGGLAVLKGNIAVDGAVVKTAGVDASILTFEGPAVVCESQEEACDKILGKQVKEGDVVVIRYEGPKGGPGMQEMLYPTSFLKGRGLGKACALVTDGRFSGGTSGLSIGHASPEAAAGGAIALVEDGDLIRIDIPNRGIELLVDEQTLAERRAALGGRYAPENRERKVSTALRAYAAMATSADKGAVRDVTKLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAP6</accession>
    <name>A0A0F7NAP6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_28940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018838.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH85605">
        <property type="protein sequence ID" value="AKH85605"/>
        <property type="gene ID" value="AA958_28940"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_28940"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6097"/>
    <dbReference type="OrthoDB" id="1478898at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045592">
        <property type="entry name" value="DUF6461"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20062">
        <property type="entry name" value="DUF6461"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH85605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="209" mass="22956" checksum="FD4F49FA9F4C7F01" modified="2015-07-22" version="1">MSSGLRWIATEYELGYTFTLCEGIEPRELLVRMGAKLEHIHELTSDAVAELQMWPEDGHLGDLDFLDWEDEALVARLTDAGFLSHPEVIVRAGAVSGWAYAIEDVSTRATAFLPALSRGTRAYTVFRSANGERQIGYARDGQVLAYYEPGMPHLGGVGAKEGVPGFVYSGQGLADVAFLRFLEREHGIYIVWEDTRAPLPTAAFAQASC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAY5</accession>
    <name>A0A0F7NAY5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_27130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018531.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_27130"/>
    <dbReference type="EnsemblBacteria" id="AKH85296">
        <property type="protein sequence ID" value="AKH85296"/>
        <property type="gene ID" value="AA958_27130"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_27130"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5717"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="325" mass="33496" checksum="A64CD83E840190C2" modified="2015-07-22" version="1">MKNSHPVPDYVGRILSSSGVPQGTCFQLAPGYLVTAWHVVQGTLALGDDGVLTVDRLRDPGADRITARVLAEDRKTDLALLAADAAFPGSARLLRASRSVAYAEPVTVVGHALMYETAGTPPVVWVEALGEWQGEVRRTDDVTLGRLHSRDVLPGMSGAPVRQRSDDSVVGVVSARYNTADGWLANSVWAGRADDVRALCAGRVELDGSRWAGFPAAAAAAGGGAAAAVAEDMLRKRREGPDIEVRTEAAPAPGREPGEPAASAAPAAPAGTGTGTGAADVPVPEPLTGPAPLPGGSGESVPDAVAEEVSQGALERVTRWILDNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAZ9</accession>
    <name>A0A0F7NAZ9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ThiF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_23495</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017933.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_23495"/>
    <dbReference type="EnsemblBacteria" id="AKH84678">
        <property type="protein sequence ID" value="AKH84678"/>
        <property type="gene ID" value="AA958_23495"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_23495"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4953"/>
    <dbReference type="OrthoDB" id="1408716at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008641">
        <property type="term" value="F:ubiquitin-like modifier activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="SSF69572"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ThiF" evidence="2">
        <location>
            <begin position="193"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH84678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="431" mass="44363" checksum="BE01B16E6F6FD41E" modified="2015-07-22" version="1">MHPMIKPALRRSWRDRHTMQMGVTRAHAVSIHPVDSATGLFLRRLDGTRGLDALRREAHRFGLSPRSVDTLVARLTRAGLIDDGPPPPNDTGTPRDDHPTSTGRPRRIHRSADAGPPVVHAAPAVVLPRDRPPSSGPSPSGPPASASRAGRVSPPGGRRRGGVIPARLRADQASLSVVHPEPGAAEARLRARRGLRVVVRGAGRVGASVAALLSAAGVGGVEVVDGGCVEPWDVAPGGAGAGDVGRRRGDAAVGAVRRAGPWQAARGGRPGGAVSLVVLAPRDGLAAYAPDPEVARRYREAGIPYVYAGVLEGTGVVGPLVLPGGSACAGCLAAARTEAEPEWPRMLAQWRAGGDREGVAACDVALATMVTGLTAAHALTFLDGRLPVCTGARLEFALPGLAWELTKLDPHPRCGCGAAAAADRDTGVAHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NB49</accession>
    <name>A0A0F7NB49_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_18805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017204.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH83907">
        <property type="protein sequence ID" value="AKH83907"/>
        <property type="gene ID" value="AA958_18805"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_18805"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3949"/>
    <dbReference type="OrthoDB" id="1545951at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="251" mass="27050" checksum="5A74EE4CF4163DAB" modified="2015-07-22" version="1">MTAADALLFDVPTPVERLLHLADQYTRHNDMLDLHLAKLAADAAPGDNTHADSAKQLAYDTRTAITAIRAERLYASTEMTEILARLTQLAFLSTASASHDVRTARDLTALAADASVGCAAALATEMRRRGAMATAPDDRLSAERRTALAEIARGHVTVSNLFDRERAQSRRHNRVRLSTLRALEKHHLADRDPSSAPATYIGGPPQDRIRLTPAGITALASVIALPQPPPGTPPAAARWPTPAHPPRARSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NB91</accession>
    <name>A0A0F7NB91_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sporulation domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_27560</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018600.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_27560"/>
    <dbReference type="EnsemblBacteria" id="AKH85366">
        <property type="protein sequence ID" value="AKH85366"/>
        <property type="gene ID" value="AA958_27560"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_27560"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5807"/>
    <dbReference type="OrthoDB" id="1587976at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042834">
        <property type="term" value="F:peptidoglycan binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018711">
        <property type="entry name" value="NAGPA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007730">
        <property type="entry name" value="SPOR-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036680">
        <property type="entry name" value="SPOR-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09992">
        <property type="entry name" value="NAGPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05036">
        <property type="entry name" value="SPOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110997">
        <property type="entry name" value="SSF110997"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51724">
        <property type="entry name" value="SPOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519336" evidence="2">
        <location>
            <begin position="27"/>
            <end position="547"/>
        </location>
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        <location>
            <begin position="91"/>
            <end position="176"/>
        </location>
    </feature>
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        <location>
            <begin position="24"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="407"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH85366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="547" mass="55330" checksum="D98C978A40458163" modified="2015-07-22" version="1">MNSKLLGAGTVLALLASAAAMPPASASVPASSAPSAPASQAAAKPLPLGDPGLTETRTTETLQPGVTLTRIVRGAGSPRLPWTVEVSIPGGEGSPDPDAPPAALRDRASAEELAAKLTGAGFAARAEEVTTPALADFAGGTLGWRVRVGSFDGQAAANAERARLVAAGYTGSAAYTGWDGDPGVRGTWRVDVLTVDPRTFRGGLTASYGPDLENREKTSELAAAAGATAGVNAGFFVLDPKAGAPGDPAGAGVYDGRVLSESVGTRPALVLRESARDTSVTRLGWQGSVTARGGALPLDGIDRVPGLIRNCGGTADDTPTPLPRHDVTCTDDDEVVAFTGEYGARTPAGDGTETVLDARGRVVEVRSPRGGPLPAGGTSVQATGAHADDLAALARPGEHLRVRHGLHDDRGRPLATPPGTAVAGGGPELVRDGRTHVTPAADGMVQPANPSFYYGWMHKRNPRTLAGVDAAGRTVLVTADGRATDSLGLSIPESADVARALGLRDAVNLDGGGSTTMAVGGEVINDPSDAAGERPVGDALLILPKRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBC8</accession>
    <name>A0A0F7NBC8_9ACTN</name>
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        <submittedName>
            <fullName evidence="8">Cell division protein FtsW</fullName>
        </submittedName>
    </protein>
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        <name evidence="8" type="ORF">AA958_24035</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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        </lineage>
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    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_24035"/>
    <dbReference type="EnsemblBacteria" id="AKH84773">
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        <property type="gene ID" value="AA958_24035"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_24035"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5066"/>
    <dbReference type="OrthoDB" id="423699at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001182">
        <property type="entry name" value="FtsW/RodA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30474">
        <property type="entry name" value="PTHR30474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01098">
        <property type="entry name" value="FTSW_RODA_SPOVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="113"/>
        </location>
    </feature>
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        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="210"/>
        </location>
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            <end position="248"/>
        </location>
    </feature>
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            <end position="270"/>
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            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="416"/>
        </location>
    </feature>
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    </feature>
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        </location>
    </feature>
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        </location>
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            <begin position="460"/>
            <end position="474"/>
        </location>
    </feature>
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            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH84773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="500" mass="51915" checksum="6E6773539E30BB6F" modified="2015-07-22" version="1">MTTATDPAQALRPPGRARRLATPPPPVPRPRRRGAELGLLVCAVGVIAYGYANVGYATSGALPAGLATHLGGLAGLALAAHLVVRFRAPRADPVLLPVALLLNGLGLVLIHRLDQDTPGDRAAPTQLLWSTVGVALFAGVLLVLRDHRDLRPRAAKYAFTALCLMAAPILFPAVNGARIWIRIGGLSLQPSEFAKVLLAVFFASYLAANRHALTFTSGPRIRRLLLPPRRVLGPIVAVWGISLVLLILERDIGASLLFFSLFVAMLYVATGRLGWLAVGLLLAAAGAAAVGALEPHVHTRVEDWLSPFRAIEEGHGPGQLAQSLFAFAAGGALGTGLGQGHSLLIGFAGKSDFILATAGEELGIAGLTALFLLYALFVARGYRTAIAIGEPFGALLAAGLAAIITLQVVVIAGGVLGLVPLTGMVTPFLAQGGSSVVTNWVIVALLVRLSDEARTPPEERPAPEAAPARPEPEPAAATAPATVPLVVPVIDEARPADGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBF3</accession>
    <name>A0A0F7NBF3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptide chain release factor 1</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">AA958_19700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017324.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_19700"/>
    <dbReference type="EnsemblBacteria" id="AKH84032">
        <property type="protein sequence ID" value="AKH84032"/>
        <property type="gene ID" value="AA958_19700"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_19700"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4151"/>
    <dbReference type="OrthoDB" id="2047548at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="11"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="143"/>
        </location>
    </feature>
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        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00472"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AKH84032.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="143" mass="16120" checksum="A8D9481730B66A80" modified="2015-07-22" version="1">MSGPHRIRGSVVLPEAELLWRFSRSSGPGGQHVNTSDTQAEVRFDLAGTQSLPPVWKERALERLADRLVDGHVVVRASEHRSQWRNRETAAVRLAALLAEATAPPPAPRRKRKVPRGVNERRLREKKQRSDVKRGRTGRGWGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBI1</accession>
    <name>A0A0F7NBI1_9ACTN</name>
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH85486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="259" mass="28131" checksum="23D41D433CC94E7D" modified="2015-07-22" version="1">MARSESVMSEDPLERAIWRLRSRGCWDDAAALLDDAAGTDAEAARQRAALLVEQCMFTAAGWERAEDAVRNAEALSIDGENRGVTACERGYLAYASTLFQERDRSDEARAALGRAAALLAPTSPYRPMLDFRRGLVAQHLTKNATAALAAFRRAHAGAVEQGDLLLCSFTWRHLASLAADAGDLAEARHGFRESLRLREEVGYLIGTAPALMALADVESEPEAGRLRAEATRLVRLLDGVPSWLAEQLGEEPRRVAAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBR6</accession>
    <name>A0A0F7NBR6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_20405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
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            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017446.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH84157">
        <property type="protein sequence ID" value="AKH84157"/>
        <property type="gene ID" value="AA958_20405"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_20405"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4299"/>
    <dbReference type="OrthoDB" id="1983361at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="94" mass="10169" checksum="C9C9BBFEDC87EFC4" modified="2015-07-22" version="1">MNDNGSAANAHQTTSQPGRGMADIRIIAGSPETAREIADVLRQRFASTAQRTYPTAEADGGTRLHFTVDTTLAPDPPGPPRPRRITRHPHSDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBR9</accession>
    <name>A0A0F7NBR9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Multidrug ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AA958_31100</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019153.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH85925">
        <property type="protein sequence ID" value="AKH85925"/>
        <property type="gene ID" value="AA958_31100"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_31100"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6572"/>
    <dbReference type="OrthoDB" id="643917at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="277"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="54"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="369"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="606"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="12"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="402"/>
            <end position="409"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AKH85925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="631" mass="65779" checksum="EF84A102EE059634" modified="2015-07-22" version="1">MTAAPGPFDDAHDGPDGARDRRGGDARDLLPTATPARTRAAVRELLRPRRALAWTAFAMMAAATAVGLLTQPLLGHIVDLVTDRREAGALTLPVVLLVAVAAGQGVLTAIGRTMVSRLGETVLAELRERFVERALRLPLDRLEKAGSGDLTARVTRDVSRVAEAVRGALPQLASSVLAIVLTLGALAVLDWRFLLAALLAVPVQAYTARWYVRRAVPLYARERVATGAQQQQLLDTVSGAATVRAHRLEALHAGRVDARSRAAVDLRLRGVRLLTGFYNRLHVAEYLGLSAVLVAGYVLVRDGSASIGTATAAALYFHSLFGPVNVALVLLDDAQAATAGLARLVGVVDARAGAGRTGPAEGPRPAVGVSVSGVSHAYEPGRPVLRDVDLELRPKEKVALVGASGAGKSTLAKLLAGIHVPAAGSIDVGGAAPDEPGRTVALVTQEVHVFAGRLADDLRLARPGADDEELREALARVGALGWAEALPEGLDTVVGEGGHRLTADRAQQLALARLVLADPPVAVLDEATAEAGSLGARRLEEAAERALEGRTALVVAHRLSQAAAADRVVVMEGGRVAESGTHDELRAADGPYAALWRAWSAGRAADAEQDAERVAERSTERQAGGAGRSGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NC17</accession>
    <name>A0A0F7NC17_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_20965</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017537.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_20965"/>
    <dbReference type="EnsemblBacteria" id="AKH84252">
        <property type="protein sequence ID" value="AKH84252"/>
        <property type="gene ID" value="AA958_20965"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_20965"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4418"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="2">
        <location>
            <begin position="296"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH84252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="384" mass="40630" checksum="96703FE7C34D03C7" modified="2015-07-22" version="1">MRPILLRRLRTAAGVLTGGLTALVELPLAALCGLWLLAAWPWQAAAGGAPRATRLPYAAAARLATAERARMTYFYGSELAPPRATPRALQYLALRWGVGALGGAVLLTALIGALYGSTLLWIWFVARDANPFVMLASGLGGLFLLFLSVQGVESVAALDNHLAHRFLGPSSADLLQRRIGELAATRAGIVAAVHDERRRIERDLHDGVQQRLVVLGLLLGRARRTGAADPDKARDLLRQAHEQSQLALTDLREVAWHVYPAALDDTGLRAALEALAERSELPVRIDYALADPLPEAVRTVAYFTVSEAVTNAIKHASATLVTVRLTRDATMAQVSIEDDGTGGADPGGGGLLGLARRVAALDGRLAVSSPPGGPTTVTAELPCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCD1</accession>
    <name>A0A0F7NCD1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_25805</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018312.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_25805"/>
    <dbReference type="EnsemblBacteria" id="AKH85068">
        <property type="protein sequence ID" value="AKH85068"/>
        <property type="gene ID" value="AA958_25805"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_25805"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5435"/>
    <dbReference type="OrthoDB" id="881553at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH85068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="1023" mass="107565" checksum="F2672FB559F7D916" modified="2015-07-22" version="1">MSTDAPAPSPAGPPADIVAFRQAMHDNAREPEGPGRNAGAERLLAEAERTGQAAFVVEALIHLLQTYNFSSEQDKMFVPFARLLRMWDECPEDFDEEDAHRLFWMFKWVSSGMTDQPHIPLAAMEKWLAEMERRYRLAGHSERAVRQAEYHIAEHVGDDARAARAYAAWRAAERDATSDCHACELRGQGSREAGHGDDAAALELWAPVLGGVHTCAHEPHATLAESLLPLLRLGRVDEARANHLRGHRMVRRMESMRFAFARHVEFCALTGNEARGLELLAERPAYLTDRGEPSSLMAYLAVTALLTRRLADLGLGAEPVVGPPGAGDPGREWKVAELGAYAEREALALASRFDARNGTAAVSSGVRERMAREPLTERLPLGLRVGRPVRRPAASAAGAAAPPAAGAPAARPGVAELLAAARELTQARRPDAVRAWADAARAAAEAGTELSVRDRAEATAHRAMHPDTADAEVAALLGTAAGLFEAAGDPGQAEVARARAAFALAREGRTDEALAAVAEPCTRALALHAEGRATAAEAATALICRARIHTMRGDGASGTQGTAAADGSAADAVAAVADFAAPYADDPRVAGRIAETYELRAELAARRGETEPAAALYAQAVDGYAAAGVPWYAVRARSALAGLASRLGDRETAERAVRGALEHSALHAQPAGQAGLHLQLADVLCNTGRDGEGAEHLLEAALWADEAGDSAGTGAWARHHLGGALLRLGRAAEAATVLEDALADLGAERHGEGTVVQTRWWLGDALGRLGEHQQAAEQYLLAAEIAAHWPREGARDHAMLATLAAQSLSSADLDTQAARAYERAGALWRDLGDVPALIRTLRSRAWLALRPEQEGAAAGRALMAEAERELTTALAATEPGAPVAAEAGGAPVRGGRRDVLLAELAATHRQTGDLITAAAGSTPHDPDESAAEAARAAYEEGLAHVERAVAGFAGLGPDCRDEYTGAHLLAAWLEADLGRPGAAARRARAVLAAYADDDAAGETAESRRDEARALLDHAGAAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-10-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCD3</accession>
    <name>A0A0F7NCD3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_30610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH85846">
        <property type="protein sequence ID" value="AKH85846"/>
        <property type="gene ID" value="AA958_30610"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_30610"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6469"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH85846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="79" mass="7671" checksum="061474366D49FD69" modified="2015-07-22" version="1">MQFGDAALAAAVTAAGLAGTHVAGGAERADAAVDGPAADTVTDVTPAGRVLGWTVNLAVAQLLIRRRRARAPGPAAAPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCU3</accession>
    <name>A0A0F7NCU3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Branched-chain amino acid ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AA958_26520</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AzlC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018431.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_26520"/>
    <dbReference type="EnsemblBacteria" id="AKH85193">
        <property type="protein sequence ID" value="AKH85193"/>
        <property type="gene ID" value="AA958_26520"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_26520"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5581"/>
    <dbReference type="OrthoDB" id="1866750at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011606">
        <property type="entry name" value="Brnchd-chn_aa_trnsp_permease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34979">
        <property type="entry name" value="PTHR34979"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03591">
        <property type="entry name" value="AzlC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="136"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="166"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="232"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="234"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AKH85193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="261" mass="25965" checksum="0F49A8E16DF4C16D" modified="2015-07-22" version="1">MATEAQPPPTADPAPEDRAALRDGLGVGVAVGLSGFAFGVTAAGAGLSAAQACAMSLLIFTGASQFALAGAVAAGGGPFAAAAGAFFLGVRNAFYGLRLAPMLRLPRALRPLAAQWVIDETAVVTIAQPTRRAQRIGFAVTGLTLYVCWNVTTLVGVLGAEAIGDTAAWGLDAAGPAVFLALVGPMLTGTVERATALVAVALVLGTLPELPPGTPVLVAALAGPLVLALHGRRTRGRAPGDPPDGTDRTDGADAREAEGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7ND36</accession>
    <name>A0A0F7ND36_9ACTN</name>
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        <recommendedName>
            <fullName evidence="1">Trypco1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_27140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018533.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH85298">
        <property type="protein sequence ID" value="AKH85298"/>
        <property type="gene ID" value="AA958_27140"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_27140"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5719"/>
    <dbReference type="OrthoDB" id="2137383at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045794">
        <property type="entry name" value="Trypco1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19493">
        <property type="entry name" value="Trypco1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trypco1" evidence="1">
        <location>
            <begin position="16"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="118" mass="12636" checksum="1E9DEE8EDC48831C" modified="2015-07-22" version="1">MNRPVHPQQEALPTVIDGRDVYIAVHRLPGSEPTSSNLRRVAGRKATEALDHVQNTIHVVAERFSRTVGELAAQTTAPESVSIEFGITIASEGNVVLFSGSAEASVAVTLTYPVPYGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7ND44</accession>
    <name>A0A0F7ND44_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Hemerythrin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_32410</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019373.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_32410"/>
    <dbReference type="EnsemblBacteria" id="AKH86146">
        <property type="protein sequence ID" value="AKH86146"/>
        <property type="gene ID" value="AA958_32410"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_32410"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6841"/>
    <dbReference type="Proteomes" id="UP000034283">
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    </dbReference>
    <dbReference type="InterPro" id="IPR012312">
        <property type="entry name" value="Hemerythrin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01814">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hemerythrin" evidence="2">
        <location>
            <begin position="27"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH86146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="180" mass="19941" checksum="9C4FC56BBFE5DBE4" modified="2015-07-22" version="1">MLWNESTRPTVPGARAPRPGEDVSAGHHLVEVHDHLREELVRLRELVVQVADGALTASAARSHIATMTLRRNNWSLGAHCAAYCRFVTLHHTTEDRQLFPELRRFDPRLAPVLDRLSEEHLVIHDVLERVDRALVAFVAGPEGTAELRGAVGLLAEALLSHLSYEEDELVAPLGRFMAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7ND50</accession>
    <name>A0A0F7ND50_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_27245</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018548.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_27245"/>
    <dbReference type="EnsemblBacteria" id="AKH85313">
        <property type="protein sequence ID" value="AKH85313"/>
        <property type="gene ID" value="AA958_27245"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_27245"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5741"/>
    <dbReference type="OrthoDB" id="1687028at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="2">
        <location>
            <begin position="261"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH85313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="485" mass="51828" checksum="4AE5475DB46E73BB" modified="2015-07-22" version="1">MRVTESTHKAPRVRGEFEVIRDGLRLLGLRTRTTRRELFREAFALTPQPALPPDAPVVRGMPPAVRRVVVRLPHMAIVALALYLFGWGSGWYGMSDSEYYDEFGTHDPFAGTLEGGHIGLPVSLAAALPLLLVLFRPVGAWWLSLVVCFAIAATITSADDWPWGEATFVSHLVVLAIAALRRSVGTAVAMWLLTTLCGLVGSWLSLRSRDEVNAVQMAVASAVVIAVAVSVRGWTAASRRAEASGALTAQERSRRTRLEKRTSIAHELHDVVAHHMSVVAIQAEAAPYRVKNPPPELTASFATIRENAVAALAELRRVLGVVRTEDYGTPSAPQPTLADLDRLLGNVRDAGLAVEKTVTGARRELPQGVELSAYRIVQEALSNVLRHAPGAPAKVELSYVLGGLALRIVNEAPAGERPPSPGAGQGVAGMRERVAMLGGRMTAGETPDGGYEVAVLLLTDDPHEALADAPVAAPADGIREKAFGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7ND75</accession>
    <name>A0A0F7ND75_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Anti-sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_23610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017952.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_23610"/>
    <dbReference type="EnsemblBacteria" id="AKH84697">
        <property type="protein sequence ID" value="AKH84697"/>
        <property type="gene ID" value="AA958_23610"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_23610"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4976"/>
    <dbReference type="OrthoDB" id="2036019at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024020">
        <property type="entry name" value="Anit_sigma_mycothiol_RsrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014295">
        <property type="entry name" value="Anti-sigma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027383">
        <property type="entry name" value="Znf_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13490">
        <property type="entry name" value="zf-HC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02949">
        <property type="entry name" value="anti_SigH_actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03988">
        <property type="entry name" value="antisig_RsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-HC2" evidence="2">
        <location>
            <begin position="11"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH84697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="113" mass="12414" checksum="428E66311A8EBCF5" modified="2015-07-22" version="1">MSCGEPHETDCSEVLDHLYEYLDKEMPEGDCAKFQVHFDECSPCLEKYGLEQAVKKLVKRCCGQDDVPADLRAKVMGRIDTIRSGDEVPDQPVLDGGDEGRPTSLEGANPPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDI9</accession>
    <name>A0A0F7NDI9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF5709 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_27980</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018672.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_27980"/>
    <dbReference type="EnsemblBacteria" id="AKH85438">
        <property type="protein sequence ID" value="AKH85438"/>
        <property type="gene ID" value="AA958_27980"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_27980"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5897"/>
    <dbReference type="OrthoDB" id="1593638at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043763">
        <property type="entry name" value="DUF5709"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18970">
        <property type="entry name" value="DUF5709"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5709" evidence="2">
        <location>
            <begin position="112"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH85438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="173" mass="18211" checksum="34AC758C48B4BA15" modified="2015-07-22" version="1">MTGSDGEEDSAAGDEVYQPYASGAPGDGSQDDEGLLPPEDTLDGFIDPLDEGYSPPEKPRGVEHTGVTAAEQRRGESLDERLAEEIPDPPLLPDDDGIGDAADTDGELIDEEVGDRRAGRLVAPDEGAHDDEEKDMIASDAGINGAAASAEEAAVHVVDEEYAYQDETPDDRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDM0</accession>
    <name>A0A0F7NDM0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_28215</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018712.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_28215"/>
    <dbReference type="EnsemblBacteria" id="AKH85478">
        <property type="protein sequence ID" value="AKH85478"/>
        <property type="gene ID" value="AA958_28215"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_28215"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5947"/>
    <dbReference type="OrthoDB" id="1911275at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="5">
        <location>
            <begin position="23"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH85478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="198" mass="20923" checksum="10A00F71563BC448" modified="2015-07-22" version="1">MEDVPHPPAVPGRRRAPARVRRHSVRGQVLDELRVAVAGGELRAGEVYSAPALGERFGVSATPVREAMQQLAAEGAVEILPNRGFRILAPSARDLAELAEVRALLLVPLLHRLAAGPPAGRLLTLSRLTGDDAEFHEALAALSGNRQLARVAGELRARARPPAATQDRRQALVDALAAGDAAAAEAVLRELLGAPERP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDM1</accession>
    <name>A0A0F7NDM1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-dehydro-3-deoxygluconokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_28470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018758.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_28470"/>
    <dbReference type="EnsemblBacteria" id="AKH85524">
        <property type="protein sequence ID" value="AKH85524"/>
        <property type="gene ID" value="AA958_28470"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_28470"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5999"/>
    <dbReference type="OrthoDB" id="1604782at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="1">
        <location>
            <begin position="24"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="323" mass="33656" checksum="9FC50D729C8C6A0B" modified="2015-07-22" version="1">MAEPAPEVLTCGEAMLLMLAEPGMPLARAVNFRRAIGGAESNVAAGLSRLGHRARWFGRVGADPAGEAVLAQLRADGVDVSYADVDPDAPTGMLLRDSHPQRAIDVQYYRAGSAASRLAPEHISPEVVEGVRVLHISGITPILSPSAAEATVKLVELAHAAGALVSFDPNVRRKLAGPERWAEVVGPLLAEADLLLAGDDELEMLTGEPADAAAARLLRGRTDTVVIKRADHTATALTAAGERVDQPPYEVRLTDPVGAGDAFATGFLSARLRDLPLDRALAEGACVAALVIQTVTDTDGLPTAAARDRALAAFTSGGDAVHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDP7</accession>
    <name>A0A0F7NDP7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">5,10-methylene tetrahydromethanopterin reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_24350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018074.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
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    <dbReference type="EnsemblBacteria" id="AKH84822">
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        <property type="gene ID" value="AA958_24350"/>
    </dbReference>
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    <dbReference type="PATRIC" id="fig|444103.5.peg.5131"/>
    <dbReference type="OrthoDB" id="1434838at2"/>
    <dbReference type="Proteomes" id="UP000034283">
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    </dbReference>
    <dbReference type="GO" id="GO:0016705">
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        <property type="project" value="InterPro"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="18"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="270" mass="29613" checksum="A72AC4D4FEB96110" modified="2015-07-22" version="1">MRFGISTFVTDKGIAPAALAVAVEERGFDSLFVTEHSHIPASRDTPFPGGGELPQVYYRTFDPIVTLTAAAVVTERLRLGTGIALIPQRDPILLAKEMASLDQVSDGRAVLGIGAGWNREEMRDHGTDPRTRFALMRERVLAMKELWTHELAEFHGEYVDFPPAYCWPKPAHPIPVLVGGWAPGTFDRIIEYGDGWFPFGASPAALVPAVAELRERAGRRVPVVVHAAPPEPKAVADLTEAGVDEITFNLRSAPRDETLRQLDRMAELLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDZ1</accession>
    <name>A0A0F7NDZ1_9ACTN</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_11860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019972.1">
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86700">
        <property type="protein sequence ID" value="AKH86700"/>
        <property type="gene ID" value="AA958_11860"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_11860"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2493"/>
    <dbReference type="OrthoDB" id="1856997at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH86700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="106" mass="11968" checksum="50974E5EF6D427BE" modified="2015-07-22" version="1">MSATETVCPRTPEAILHALERKPEWLESFQQEWMAAAADFSADALAAVLDKWHPAAIACATPGHLDEVEDMVRRLDAGDDADLVFYDEDGRAWSAENERRPDRDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NE92</accession>
    <name>A0A0F7NE92_9ACTN</name>
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        <recommendedName>
            <fullName evidence="3">Proline dehydrogenase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AA958_25590</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a quinone + L-proline = (S)-1-pyrroline-5-carboxylate + a quinol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23784"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17388"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.5.5.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
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            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="7">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 1/2.</text>
    </comment>
    <dbReference type="EC" id="1.5.5.2" evidence="3"/>
    <dbReference type="EMBL" id="CP011492">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_25590"/>
    <dbReference type="EnsemblBacteria" id="AKH85032">
        <property type="protein sequence ID" value="AKH85032"/>
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    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_25590"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5395"/>
    <dbReference type="OrthoDB" id="1746057at2"/>
    <dbReference type="UniPathway" id="UPA00261">
        <property type="reaction ID" value="UER00373"/>
    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004657">
        <property type="term" value="F:proline dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010133">
        <property type="term" value="P:proline catabolic process to glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
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        <property type="entry name" value="PRODH_bac_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002872">
        <property type="entry name" value="Proline_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015659">
        <property type="entry name" value="Proline_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13914">
        <property type="entry name" value="PTHR13914"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Pro_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000196">
        <property type="entry name" value="Pro_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF51730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0274">FAD</keyword>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pro_dh" evidence="8">
        <location>
            <begin position="43"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
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        <location>
            <position position="163"/>
        </location>
        <ligand>
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        </ligand>
    </feature>
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        <location>
            <begin position="187"/>
            <end position="189"/>
        </location>
        <ligand>
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        </ligand>
    </feature>
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        <location>
            <begin position="226"/>
            <end position="227"/>
        </location>
        <ligand>
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        </ligand>
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        </ligand>
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        <location>
            <position position="289"/>
        </location>
        <ligand>
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        </ligand>
    </feature>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
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            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000196-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH85032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="308" mass="34035" checksum="23A1DD8F523F0299" modified="2015-07-22" version="1">MLGPVLLAAARSDGIRRLVSAAPVSRQVVARFVAGEELADAVAAVRDLSARGLEVTLDHLGEDVTDPREALRARDAYLALTEALTHEGLGARAEMSVKLSAFGQALPGGHDLALAHVTPVVEAAAAAGTTVTLDMEDHTTVDSTLAILHTLRERFPQTGAVLQAYLFRTEEDCRDLAGEGSRVRLVKGAYKEPAVVAFQDRAEVDRAYVRCLKILMTGRGYPMIGTHDPRMIAITQELARRHGRKTDEYEFQMLYGIRTQEQQRLVAEGHRMRVYTPYGTDWYGYFMRRLAERPANTAFFLRALAGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NER8</accession>
    <name>A0A0F7NER8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_15310</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_15310"/>
    <dbReference type="EnsemblBacteria" id="AKH86791">
        <property type="protein sequence ID" value="AKH86791"/>
        <property type="gene ID" value="AA958_15310"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_15310"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3223"/>
    <dbReference type="Proteomes" id="UP000034283">
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
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        <property type="entry name" value="RNA_pol_sigma-B/F/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
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    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02980">
        <property type="entry name" value="SigBFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00715">
        <property type="entry name" value="SIGMA70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RNA_pol_sigma70" evidence="6">
        <location>
            <begin position="79"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH86791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="276" mass="30313" checksum="0A93ADA553C3492A" modified="2015-07-22" version="1">MPAPAAPADDAAPVEADAAPSGSIDTRTLSRALFLRLAELPPGDSPERSYVRDTLIELNLPLVRYAAARFRSRNEPMEDIVQVGTIGLIKAIDRFDCRRGTEFPTFAMPTVIGEIKRYFRDTSWSVRVPRRLQELRLALTKASDDLAQQLDRSPTVPELAQYLGVSDEDVVDGLAVGNAYTASSLDSPAPEEDGGEGSLADRLGYEDSALEGVEYRESLKPLLAQLPARERRIIMLRFFGNMTQSQIGDEVGISQMHVSRLLTRTLAQLRAGLIAD</sequence>
</entry>
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    <name>A0A0F7NEX1_9ACTN</name>
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            <fullName evidence="2">dUTPase</fullName>
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        <lineage>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
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        <property type="gene ID" value="AA958_26945"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_26945"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5670"/>
    <dbReference type="OrthoDB" id="1959396at2"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="entry name" value="DUF4193"/>
    </dbReference>
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        <property type="entry name" value="DUF4193"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="99" mass="11088" checksum="3F63B9F29248DB9B" modified="2015-07-22" version="1">MATDYDTPRKTDDDVNEDSIEELKARRSDKSAAAVDVDEFEQNEGLELPGADLSNEELSVRVLPRQEDEFTCMSCFLVHHRSQLAAEKNGQPICRDCAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NF29</accession>
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        <name evidence="3" type="ORF">AA958_31150</name>
    </gene>
    <organism evidence="3 4">
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        <lineage>
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            <taxon>Actinobacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
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    </dbReference>
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH85933">
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        <property type="gene ID" value="AA958_31150"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_31150"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6582"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="153"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH85933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="298" mass="30667" checksum="9D00C523B6D1CF06" modified="2015-07-22" version="1">MVSAPVLVGVDGSAEGLAAVAVAAREARLRGTALRVVHAFFWPMMRVPLEPSSMGPPEGGLRNQAEQVVAEAVRHAREAEPDVEAEGAVVTGDTLPVMAEESRGAVLAVVGSRGLGAFAGLLLGSTAVHLAAHGHCPVLVVRGEGGPAREGPVVAGVDGSRSGDAAVGFAFAEASMRGTGLVAVHAWSPWRDEAPRPQDPAAPYASGSGDLAVNEERVLAESLAGRQERYPDVSVDRRVLRGGPREALIEASREASLVVVGARGRGGFTGMLLGSVSQALLHHAHSPVAVVRPEPDTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFF2</accession>
    <name>A0A0F7NFF2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ADP-ribose pyrophosphatase</fullName>
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    </protein>
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        <name evidence="1" type="ORF">AA958_33175</name>
    </gene>
    <organism evidence="1 2">
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        <lineage>
            <taxon>Bacteria</taxon>
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        </lineage>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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    </dbReference>
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    <dbReference type="STRING" id="444103.AA958_33175"/>
    <dbReference type="EnsemblBacteria" id="AKH87205">
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    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_33175"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.7008"/>
    <dbReference type="OrthoDB" id="1550873at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="entry name" value="DUF4916"/>
    </dbReference>
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        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16262">
        <property type="entry name" value="DUF4916"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH87205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="176" mass="19289" checksum="4668D979D8464B72" modified="2015-07-22" version="1">MTETTPGWLAPEELESARARMPVLYVDAVPVRVDDRGEVTHVGLLLRIGPDGAVSRALVSGRVLHHERVRDALLRHLEKDLGPVALPRVPSSPQPFTIAEYFPTQGLTPYHDPRQHAVSLAYIVPVAGDCRPRQDALDFVWFTPQEAASPVVQQEMPGGQGHLLKQALAHVGYVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFH3</accession>
    <name>A0A0F7NFH3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Plasmid stabilization protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_32845</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
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            <taxon>Streptomyces</taxon>
        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_32845"/>
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    <dbReference type="OrthoDB" id="1882650at2"/>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="107" mass="12009" checksum="A8AF2EC53504718E" modified="2015-07-22" version="1">MPSGSSQKRERQYEHIKEGAQRRGTGTRRAKEIAARTVNKERARTGEARTASRTSTRDISSGRRGGLRSHSGPGGPTYDQLYAEARRRNIRGRSSMNKAQLKRKLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFJ3</accession>
    <name>A0A0F7NFJ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_32170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019336.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_32170"/>
    <dbReference type="EnsemblBacteria" id="AKH86108">
        <property type="protein sequence ID" value="AKH86108"/>
        <property type="gene ID" value="AA958_32170"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_32170"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6793"/>
    <dbReference type="OrthoDB" id="957193at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="23"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="307" mass="34328" checksum="A9B93F849B1A1616" modified="2015-07-22" version="1">MTYEHQSRQPEAKRPEDVRVGAVVITMGQRPEELRALLESVAKQDGAPVEVVVVAQGVTVPNIPQGVRVVELPENLGIPGGRNVGIEAFGEGGRDVDVLLFLDDDGLLPQQDTARLVREAFAADPRLGIVSFRIADPETGVTQRRHVPRLRASDPMRSSRVTTFLGGANAVRTEVFQEVGGLPDDFFYAHEETDLAWRALDAGWHIDYRADMVLHHPTMPPSRHATYHHNVARNRVWLARRNLPAPLVPVYLGVWFLLTVARSPSPAVLKSWLVGFREGWRAPCGPRKPMKWRTVWRLTRLGRPPVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFK9</accession>
    <name>A0A0F7NFK9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH arsR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_33060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019476.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_33060"/>
    <dbReference type="EnsemblBacteria" id="AKH86249">
        <property type="protein sequence ID" value="AKH86249"/>
        <property type="gene ID" value="AA958_33060"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_33060"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6984"/>
    <dbReference type="OrthoDB" id="1617768at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="254"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="327" mass="35443" checksum="2C91980B52E3BBF1" modified="2015-07-22" version="1">MAGTLRIHFGDRDFRHVQLTGSADPMWEAILGLHVLSTPPARLPARLRPWRRRAAARLHGGELRAACRLLRDLAPADAAYFPDFLTPVESEEGLSAALETLLATPGRRLARELREAARHRPLPAWTRRLAAGDRVQLGRVADAVRQFHARLIVPEWSEVEATIAADREWRMAALDGGMPAVLGTLRPFRWRGGVLTAPYPVDYDLRLRGRGVRLIPSFFCHTAPIAIADPSLPPVVVYPVRRQPAGPVPGRPPPALAALLGTARARVLDALAATATTGSVAARLGIPASTVSGHLTVLRGAGLVRSERAGAHVVHRLTGRGRHLLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFT4</accession>
    <name>A0A0F7NFT4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AA958_33385</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019534.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86309">
        <property type="protein sequence ID" value="AKH86309"/>
        <property type="gene ID" value="AA958_33385"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_33385"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.7050"/>
    <dbReference type="OrthoDB" id="1155802at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04590">
        <property type="entry name" value="CBS_pair_CorC_HlyC_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044751">
        <property type="entry name" value="Ion_transp-like_CBS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="DUF21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0129">CBS domain</keyword>
    <keyword evidence="5 7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="10">
        <location>
            <begin position="1"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="9">
        <location>
            <begin position="221"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="9">
        <location>
            <begin position="288"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AKH86309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="371" mass="39033" checksum="094010E168011B17" modified="2015-07-22" version="1">MSALHLAFAALLVLANGFFVGAEFALVSVRRSQIEPHAAAGSARARRVLHGLEHLPQMMAAAQFGITVCSLTLGALAEPAIASLLEPAFHAAHVPHGLIHPLGYAVSLAVVVCLHLVIGEMVPKNLALAAPAAAALWLAPGLVAFARICRPVTALLGALARHMLRLVRVEPRSALTSVYTTEQLTDLVADSRDAGLLGDGEQRRLNDALGLGSRPVTDVLLDPGSMVAVTASATPRQVEELTVRTGYSRFPVRDAGGSGAAGPTYLGYLHVKDVLELDERERAVPAHLFRPMTVLRPELPLDDALAAMRRDASHLAAVADPAAPGRVLGLVTLEDVLELLVGEVRDPAHRLTVRQRTADGTAAESVPTSVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFY9</accession>
    <name>A0A0F7NFY9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ferredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_29315</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018891.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_29315"/>
    <dbReference type="EnsemblBacteria" id="AKH85662">
        <property type="protein sequence ID" value="AKH85662"/>
        <property type="gene ID" value="AA958_29315"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_29315"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6182"/>
    <dbReference type="OrthoDB" id="1873445at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001080">
        <property type="entry name" value="3Fe4S_ferredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010693">
        <property type="entry name" value="Divergent_4Fe-4S_mono-cluster"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06902">
        <property type="entry name" value="Fer4_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00352">
        <property type="entry name" value="3FE4SFRDOXIN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="2 4" id="KW-0408">Iron</keyword>
    <keyword evidence="3 4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Fer4_19" evidence="5">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU368020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF06902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH85662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="64" mass="6816" checksum="0BA86A08E8F7C147" modified="2015-07-22" version="1">MRIEADTDTCVGSGMCALTTPELFDQSDKDGTVVLLRSVPTDVQLKDAEDAVRRCPSGALSLTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NG13</accession>
    <name>A0A0F7NG13_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glutathione S-transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_33155</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019493.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_33155"/>
    <dbReference type="EnsemblBacteria" id="AKH86268">
        <property type="protein sequence ID" value="AKH86268"/>
        <property type="gene ID" value="AA958_33155"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_33155"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.7004"/>
    <dbReference type="OrthoDB" id="780709at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
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        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016639">
        <property type="entry name" value="GST_Omega/GSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32419">
        <property type="entry name" value="PTHR32419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015753">
        <property type="entry name" value="GST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01206">
        <property type="entry name" value="Xi.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="SSF47616"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST C-terminal" evidence="3">
        <location>
            <begin position="160"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="317"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR015753-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH86268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="344" mass="38459" checksum="D6D84BA8B6A8CEF5" modified="2015-07-22" version="1">MSSSPSDVAGQGNTEYGRKRFKRSRSHFADRITAAGEDGWPVEAGRYRLVVNRACPWANRTLISRRLLGLESAISIGVTDPIQDDRSWRFTLDPGDRDPVLGIRFLSEAYDARETGYPGGVSVPAIVDVPSGKLVTNDFQQITLDFATEWTALHREGAPDLYPEALRDEIDEVMDGVYRNVNNGVYRAGFATTQDEYEVAYHDVFRQLDELSARLSGRRYLVGDTITEADIRLFTTLVRFDPVYQGHFKCNRNKLAEDKVLWAYARDLYQTPGFGDTVDFDHIKRHYYEVHTGINPTGVVPAGPDLSGWLSPHHREQLGGYPFGDGTPPAPPPEAERVPAAGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NG17</accession>
    <name>A0A0F7NG17_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_33185</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the intradiol ring-cleavage dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019498.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_33185"/>
    <dbReference type="EnsemblBacteria" id="AKH86273">
        <property type="protein sequence ID" value="AKH86273"/>
        <property type="gene ID" value="AA958_33185"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_33185"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.7010"/>
    <dbReference type="OrthoDB" id="1456634at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006725">
        <property type="term" value="P:cellular aromatic compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003610">
        <property type="entry name" value="CBM_fam5/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036573">
        <property type="entry name" value="CBM_sf_5/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000627">
        <property type="entry name" value="Intradiol_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015889">
        <property type="entry name" value="Intradiol_dOase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00775">
        <property type="entry name" value="Dioxygenase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00495">
        <property type="entry name" value="ChtBD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49482">
        <property type="entry name" value="SSF49482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51055">
        <property type="entry name" value="SSF51055"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chitin-binding type-3" evidence="6">
        <location>
            <begin position="234"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="56"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH86273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="280" mass="30172" checksum="6EA446453C9AE43E" modified="2015-07-22" version="1">MTDQDKSAPDEGAQPQEKSGIRRKDLLKAALVAAPLPLLVGGAAAPVLARDQAEAGGELTPTPEACDPGDPPTMQQTEGPYFKPNSPQRTSLVDPGTPGTRLTVSGYVFGLTCQPVPHALLDFWQADVNGAYDNTGYRFRGHQYSDAQGRFSLQTIVPGLYPGRTRHIHVKVQAPNQPILTTQLYFPNEPRNNTDTIFHPSLLMTVRDVGGGREGTFDFVLNVRQNPDPPDPPGGTWAAGSSYRSGDTVTYGGVTYRCLQAHTASPGWEPPNVPALWQAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NG19</accession>
    <name>A0A0F7NG19_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alpha-L-rhamnosidase</fullName>
            <ecNumber evidence="2">3.2.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AA958_33725</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing alpha-L-rhamnose residues in alpha-L-rhamnosides.</text>
            <dbReference type="EC" id="3.2.1.40"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.2.1.40" evidence="2"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019591.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_33725"/>
    <dbReference type="EnsemblBacteria" id="AKH86369">
        <property type="protein sequence ID" value="AKH86369"/>
        <property type="gene ID" value="AA958_33725"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_33725"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.7120"/>
    <dbReference type="OrthoDB" id="170130at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030596">
        <property type="term" value="F:alpha-L-rhamnosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016007">
        <property type="entry name" value="Alpha_rhamnosid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035396">
        <property type="entry name" value="Bac_rhamnosid6H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035398">
        <property type="entry name" value="Bac_rhamnosid_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013737">
        <property type="entry name" value="Bac_rhamnosid_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008902">
        <property type="entry name" value="Rhamnosid_concanavalin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05592">
        <property type="entry name" value="Bac_rhamnosid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17389">
        <property type="entry name" value="Bac_rhamnosid6H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17390">
        <property type="entry name" value="Bac_rhamnosid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08531">
        <property type="entry name" value="Bac_rhamnosid_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010631">
        <property type="entry name" value="A-rhamnsds"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_rhamnosid_N" evidence="6">
        <location>
            <begin position="373"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_rhamnosid" evidence="5">
        <location>
            <begin position="554"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_rhamnosid6H" evidence="7">
        <location>
            <begin position="659"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_rhamnosid_C" evidence="8">
        <location>
            <begin position="995"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="512"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH86369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="1096" mass="118307" checksum="1247450EA12C7D75" modified="2015-07-22" version="1">MSHERETNNGSAWNRRAFLRTSAAAGAAAGVIGLGQGAVPAAAAGRGGGDGGDGGEEGLRVERTTVEYAPSLLGTDIAAPRLSWELSAPGSGARQSAYQVRVAPDTEGDGPLVWDSGRVASARTVGVAYGGPALETRTRYHWQVRVWDGRGRPSAWSRWSWWETALADGDWQGHWIGADAAPAPPGFAGASWIWAPGATPQNAPAGPVWFRAALELPAGAEVSAARIVATADDDFTLFLDGTQVLHAPQQTDGWRTGRQADVTDAVRAADGRVVVAVRATNRGGASVNPGGLLVRLMVHRGDDVTELVTGPGWRCADQEQDGWQHPGFDDGAWAAATVLAPYGQGPWGSGAAVPAEVRPAPLLRREFSVGRPVRRARLYLSGLAYYDAEINGRRVGRQVLDPGFTDYDETVLYAVHDVTDLVTRGANAIGVTLGRGFFGMTTPNVWNWHTPPWHGEPRLLAQLEIEHPGGARTTVATDGSWRITEGPTRSDCLYAGETYDARKHPAGWTRPGFDDTGWARPARQDPPKGSLRAQPHDAIRVIDTVRPVAVTAHGDTWIVDMGRTLAGWSRLSVRAPAGTVVRLVHGEKLKADGSVHAETGHVPGRFQTDEYVCAGGGSAEVWEPKFSYKGFRYVQISGLPAKPGPGDVLGRVVHTPVADTGTFGCSEPFYEQLERAMRRTVQNNLHGIPTDTPMYEKNGWTGDAQVGAPVMMYALGMQRMLGKWLDDIRDSQNAAGQLPVIVPSGGWGYGDLGPSPEWTTVYPFLIREMYRVYGDERVVRDHLPALTRYLDWELDRLVDGLAVTALGDYLPPGYGGNPPEDTRLTATSYLHRALTDTAAMADLAGESGTRDRYLAAADGLKEALNAAFLAPEGHYRTAKDPDYRQTNNCIPLAFGLVPAGARASVTASLLGDIEKRGNHLNTGALGTSVLLRALTAEGHADVAHAIATQRTYPSWGYWFDNGADTMWEMWQLDSRSRDHYFQGTVVQWLYENVAGLRPGDAGYRTFAVRPDARTGVDWARTELHTVRGPAAVSWSRIDQTVRLAVRVPVGSTAEVHVPSGSRGDVREPEGAEFVRTEPGFAVYRVPHGSWTFTGKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NG26</accession>
    <name>A0A0F7NG26_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Molecular chaperone GroES</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_29570</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018926.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_29570"/>
    <dbReference type="EnsemblBacteria" id="AKH85697">
        <property type="protein sequence ID" value="AKH85697"/>
        <property type="gene ID" value="AA958_29570"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_29570"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6240"/>
    <dbReference type="OrthoDB" id="787596at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027399">
        <property type="entry name" value="ADH_N_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13823">
        <property type="entry name" value="ADH_N_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ADH_N_assoc" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="domain" description="ADH_N" evidence="4">
        <location>
            <begin position="26"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="ADH_zinc_N" evidence="3">
        <location>
            <begin position="189"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH85697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="393" mass="42230" checksum="9C71AD97FADDA29A" modified="2015-07-22" version="1">MRAAVWHGKRDVRVEEVPDPSLKHPTDAVVRITSSGLCGSDLHLYEILTPFMTPGDILGHEPMGVVEEVGGEVTNLSPGDRVVVPFQIACGDCHMCRQGLQTQCETTQVREHGMGARLFGYTKLYGAVPGAQAEYLRVPQAHYGPVKVPEGPADDRYLFLSDVLPTAWQAVEYAGIPEGGSVAVIGLGPIGDMCCRIALHRGAGQVIGVDLVDERLRRVRERGAEAIDLRDEKDVAAAVRDRTRGRGPDAVIDAVGAEAHGSPAGKLMQTIGGLLPGKLAEQVAGKVGVDRMAALYTAFDMVRRGGTVSVIGVYGGAADPLPLLTVFDKQLQLRFGQANVRRWVPDILPLLEGEDVLGVDSFATHHLPLERTPDAYEMFQKKADGAVKVVLEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NGI5</accession>
    <name>A0A0F7NGI5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptide ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_33920</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019625.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_33920"/>
    <dbReference type="EnsemblBacteria" id="AKH86403">
        <property type="protein sequence ID" value="AKH86403"/>
        <property type="gene ID" value="AA958_33920"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_33920"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.7162"/>
    <dbReference type="OrthoDB" id="1303270at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="30"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="62"/>
            <end position="69"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH86403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="365" mass="39233" checksum="813A9DB41DF5ACC1" modified="2015-07-22" version="1">MTGTALPDAAAAARTAPALEVRGLRTHFPVKRGFLGRTVGHVRAVDGVDLSVRPGETLGLVGESGCGKTTLGRSVARILRPTSGRISYRPEAGAEPVDVAALSGRGLRAYQRQVRVVFQDPFSSLNPRMTLLQIVGEPLRSYGIATGAELEDRVAAMLTRVGLSPKYLHRYPHAFSGGERQRVSIARALIVDPKLVVADEPVSALDVSVRAQILNLLRDLQEEFALTYLFISHDLSVVESVCDRVAVMYLGRIVELAGTDELYARPRHPYTEALLSAVPRPDPRLRGGARRIRLSDDLPDPAHPPAGCPFRTRCRFARPGLCDVPEKPPALVPATGGTDPGHRVACHLAGELTLTGVHETPGATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NGI7</accession>
    <name>A0A0F7NGI7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glucoamylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_04960</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019790.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_04960"/>
    <dbReference type="EnsemblBacteria" id="AKH86554">
        <property type="protein sequence ID" value="AKH86554"/>
        <property type="gene ID" value="AA958_04960"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_04960"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1043"/>
    <dbReference type="OrthoDB" id="318658at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011613">
        <property type="entry name" value="GH15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045582">
        <property type="entry name" value="Trehalase-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19291">
        <property type="entry name" value="DUF5911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00723">
        <property type="entry name" value="Glyco_hydro_15"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5911" evidence="2">
        <location>
            <begin position="2"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_15" evidence="1">
        <location>
            <begin position="209"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_15" evidence="1">
        <location>
            <begin position="530"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH86554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="588" mass="66184" checksum="309626FE5553689F" modified="2015-07-22" version="1">MQTAALVRRDGTADWLCLPRFDSHAVFASLLGTEEHGFWRLGPAYAPESTPPPATRRRYRGDSLVLESEWDTPRGTVRLIDFMPPRDSASPQLIRIVEGVTGRVPMRSALRMRFSYGRIVPWVHQTEDGRTVGVAGPDSVWLDAPVPTYGRDLTTYSDFTVGPGDRLAFTISWQPSHREPPQPADPEASLTATEDFWQEWTEHCTYHGPYRHAVIRSLITLKALTYEPTGGIVAAPTTSLPEDVGGVRNWDYRFTWLRDAAITLSSLLRTGYHEEARAWREWLLRAVAGDPENLQIMYGIAGERELGESELDWLPGYEGSRPVRAGNGAAGQLQLDVYGEVVEALHLAHMTGLTRNDYAALLQLKMIRWVEDNWDRPDEGLWEVRGPRRHFVHSKVMTWVAVDRTIKLIESGEADGPLERWQRLRDDIHRDVCEKGYDRQRNTFTQSYGSQELDASLLLIPQVGFLPPDDKRVIGTIEAIQRELGTPDGFIRRYPTAGDETGSDGLPGDEGAFLACSFWMADDLAMIGRVQEARQLFEKLLALRNDLGLLAEEWDPRLQRQVGNFPQAFSHVPLIDTALRLSASGAYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NGN6</accession>
    <name>A0A0F7NGN6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Calcium-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_00265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019668.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_00265"/>
    <dbReference type="EnsemblBacteria" id="AKH86458">
        <property type="protein sequence ID" value="AKH86458"/>
        <property type="gene ID" value="AA958_00265"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_00265"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.63"/>
    <dbReference type="OrthoDB" id="1913389at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="SSF47473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="1">
        <location>
            <begin position="4"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="177" mass="19004" checksum="EE6DACBD6C603C2D" modified="2015-07-22" version="1">MRDEAAKRVELVFSLFDANGDGVIDSHDFDLMTGRVLQAAAASDDDAKAAIRAAFRRYWTTLASELDANGDGVITLDEFRPFVLDPERFGPTIAEFAEALSSLGDPDGDGLIERPLFVSLMTAIGFEEANIHALFDAFGPDAEDRITVATWAAGIKDYYAPDMAGIPGDELVAARAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NGP3</accession>
    <name>A0A0F7NGP3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AA958_30935</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019125.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH85897">
        <property type="protein sequence ID" value="AKH85897"/>
        <property type="gene ID" value="AA958_30935"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_30935"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6538"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028081">
        <property type="entry name" value="Leu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13458">
        <property type="entry name" value="Peripla_BP_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="15"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="300"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH85897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="730" mass="75674" checksum="1FA330973D8C4173" modified="2015-07-22" version="1">MERLLPSDPAHLGGNRLLGRLGAGGMGVVYLARTRAGSPAAVKVIQPEYAERPEFRARFRREAASARRVASPWVVPVLDADTEADAPWLATAFVPGPSLAEAVEACGPLPGHGVRVLGKVLARAVAAVHDAGLVHRDLKPGNVLLALDGPRLIDFGIARPTAAEETELTSDSMVVGTPGFLSPEQARAQRVGPASDVFSLGCVLAYAATGRPPFGTGAADALLYRTVHDEPDLDGLADEGLRALLVRCLSKEAEGRPTAAGLDAELVADAPEGDIDWLPDAVVRMVAERSAEMLRLPGVEPTEVSGTRAGDAGDVDTTAAPAAPARPGRRRILALAGGGALLAAGGGAALWAVLRDDGEAPAEARGPRRTLGLHADLTGPQREAGAAQERAARLAVEQFNARENAPFTLELTVADDGGDPARALTVARRLVGDRDVLAVLGPTGYGSAQASLDAYNGAGMPLLTVSEGSYSAAQAALVNGEPKAYFHATALSLRPALTTVYVLLGQGAANIGLLSDRAGGIRAFEHSTIAHNAATGAELGLYLRVVPAAADAGALGPVVADIVDHGVDGFFYTGTPERAAAVARELAKRGFDGPRFLDEPAAGGAFTAAAADAAEGWQTLTPYVGADADAVRDFAAAYRKRFGGAPGPWAAEAYDVTRLIADRLAALARKSRRRPTREALAASLTAARFKGLTATYSFDESREIEQGKIHHYRVEDGRFGYVGPVALPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NH70</accession>
    <name>A0A0F7NH70_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ARMT1-like_dom domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_15595</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>beta-D-fructose 1-phosphate + H2O = D-fructose + phosphate</text>
            <dbReference type="Rhea" id="RHEA:35603"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:37721"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:138881"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>beta-D-fructose 6-phosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone</text>
            <dbReference type="Rhea" id="RHEA:28002"/>
            <dbReference type="ChEBI" id="CHEBI:16016"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the damage-control phosphatase family. Sugar phosphate phosphatase III subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020100.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_15595"/>
    <dbReference type="EnsemblBacteria" id="AKH86799">
        <property type="protein sequence ID" value="AKH86799"/>
        <property type="gene ID" value="AA958_15595"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_15595"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3283"/>
    <dbReference type="OrthoDB" id="435730at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036075">
        <property type="entry name" value="ARMT-1-like_metal-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039763">
        <property type="entry name" value="ARMT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002791">
        <property type="entry name" value="ARMT1-like_metal-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12260">
        <property type="entry name" value="PTHR12260"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01937">
        <property type="entry name" value="ARMT1-like_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111321">
        <property type="entry name" value="SSF111321"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ARMT1-like_dom" evidence="6">
        <location>
            <begin position="41"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH86799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="408" mass="44127" checksum="ACE008F8E704D0B0" modified="2015-07-22" version="1">MTETTSGSAGDEAGRGTGTAAGNGAPVILSNEPGSFARDVLAERHPALIEQVRDAFPYGRRQHDALDALLDEITNGVVEPLPRSEHDHAAWSEWGQGHFGRSWFDVPFLWAESYFYRRLLGAIEYFGSGPWQGIDPFAPFKEAELRGTAVDNELRALDALAGAPAGERAAALLHAALWGNRADLGFRVTAAEPAAGDTDGGLVADDSAVLWRLLPAGALAPVAVVADNAGRELIPDLVLVDHLLEHGHAEQVALHVKPAPYYVSDATLPDVVDCLRRLTEAPGEAGTIGGRLWKAMATGRMEVRAHPFFCAPLPYEEMPGDLRKEFEAVSLTIFKGDLNYRRLVGDRKWHATVPFAERTAHFPRAVAALRTLKSDVVVGLEQGTVETLERSGAAWRTDGTHALTQVRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NJJ3</accession>
    <name>A0A0F7NJJ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Carboxyvinyl-carboxyphosphonate phosphorylmutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_21770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020307.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_21770"/>
    <dbReference type="EnsemblBacteria" id="AKH86952">
        <property type="protein sequence ID" value="AKH86952"/>
        <property type="gene ID" value="AA958_21770"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_21770"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4585"/>
    <dbReference type="OrthoDB" id="1485205at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00377">
        <property type="entry name" value="ICL_PEPM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039556">
        <property type="entry name" value="ICL/PEPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH86952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="245" mass="25217" checksum="211D35B9AD88DF49" modified="2015-07-22" version="1">MAGRAEEFRALHHGREAGDPLVLPGPWDAASARVFADAGFAALATPSAGIARALGYGDGEATPVAEMFAAITRITRAVDVPVTADVEAGYGLPPRELVERLLEAGAVGCNLEDTVHPGRTLRDAAEQAEFLAEVKAEAGDGLFINARVDTFVRGVEDPGAAVERGRLYAAAGADGVYPIGAPPRHLGLLAQETGLPVNALAAAEGRGPGPAELGRLGASRITFGGGLLERTLRGVEELARELGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NK36</accession>
    <name>A0A0F7NK36_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Maleylpyruvate isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_30845</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020583.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_30845"/>
    <dbReference type="EnsemblBacteria" id="AKH87157">
        <property type="protein sequence ID" value="AKH87157"/>
        <property type="gene ID" value="AA958_30845"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_30845"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6519"/>
    <dbReference type="OrthoDB" id="1760896at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024344">
        <property type="entry name" value="MDMPI_metal-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11716">
        <property type="entry name" value="MDMPI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MDMPI_N" evidence="1">
        <location>
            <begin position="7"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH87157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="218" mass="22979" checksum="A35AFB3DDAFDCEF2" modified="2015-07-22" version="1">MEQFVPSWAALRAAVAGLRDEDFAQPSGCTGWLVRDLASHLVIDAQDVLITLVTPADGEPTVDAARYWHVSDEPPTGADPLDALTVRLAAAYEDPALLKFHLDDVGSAAGRAAQLADPALRVSTQDMVLTAGDYLAAYVLEWTLHHLDLTAHLPHVPGPPAAGLADTRALLERIAGAAFPASFTDTDALLIATGRRTPTEAERTALGPLAAKLPLILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MXN8</accession>
    <name>A0A0F7MXN8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Elongation factor Tu</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_01195</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014375.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_01195"/>
    <dbReference type="EnsemblBacteria" id="AKH81010">
        <property type="protein sequence ID" value="AKH81010"/>
        <property type="gene ID" value="AA958_01195"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_01195"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.262"/>
    <dbReference type="OrthoDB" id="621774at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01884">
        <property type="entry name" value="EF_Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041709">
        <property type="entry name" value="EF-Tu_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004541">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_bac/org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004160">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03143">
        <property type="entry name" value="GTP_EFTU_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="SSF50465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00485">
        <property type="entry name" value="EF-Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="6">
        <location>
            <begin position="10"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH81010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="389" mass="41224" checksum="3C094F796AF14E7A" modified="2015-07-22" version="1">MPKQAYVRTKPHVNIGTMGHVDHGKTTLTAAITKVLSDRGTGTFVPFERIDRAPEESVRGITINIAHVEYETATRHYAHVDMPGHADYVKNMVTGAAQLDGAILVISAADGVMPQTAEHVLLARQVGVRHVVVALNKADAGDPELTDLVELEVRELLTKHGYPGEEVPVVRVSGLRALEGDPAWTQAIADLLDAVDTYVPMPERHLDAPFLLPVENVLTITGRGTVVTGAVERGTVRVGDRVQVLGADAETVVTGLETFGRPMDSAQAGDNVALLLRGVARDAVRRGHVVAAPGTVVPRRRFTAEVYVLSAAEGGRRTAVSTGYRPQFYIRTGDVVGDVDLGAAGVARPGDTVAMTVELGREVPLEVGLGFAIREGGRTVGAGTVTGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MXQ9</accession>
    <name>A0A0F7MXQ9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glyco_hydro_35 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_01330</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 35 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014395.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_01330"/>
    <dbReference type="EnsemblBacteria" id="AKH81030">
        <property type="protein sequence ID" value="AKH81030"/>
        <property type="gene ID" value="AA958_01330"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_01330"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.294"/>
    <dbReference type="OrthoDB" id="831762at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031330">
        <property type="entry name" value="Gly_Hdrlase_35_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001944">
        <property type="entry name" value="Glycoside_Hdrlase_35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23421">
        <property type="entry name" value="PTHR23421"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01301">
        <property type="entry name" value="Glyco_hydro_35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519566" description="Glyco_hydro_35 domain-containing protein" evidence="4">
        <location>
            <begin position="38"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_35" evidence="5">
        <location>
            <begin position="64"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH81030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="586" mass="61815" checksum="D8CE53662A5A18DB" modified="2015-07-22" version="1">MSTPPAITPSRRTVLGGLGAAAVTTPGVLGGAPEASAAASSPAPAAAAGTRRAAGPVTYRNKQIHIDGGPALVLGGEIPHFRLKCGDWRSRLDKAKTAGLNAIATYIPWMWHETPDGRIDVTGRTRPERDLGAFPDLCIENGFDAVVRPGPFTMAELKGGGVPERVRREHPEINPKGWHGADATTPAVDHLAPAFLEEARRWYDAVMPVIARRLRADGRPGIIACQLDNEIGMRAEYDDLALGFVPDHYLTEYHPDTDAVRAVVSDVEPVRGSGPRGAPIRGMLLGGYRYRSVDLQAGDLDPARTPVPGPATGEYLDTVVQRRLVRYLRAGGKLLLSGLLPGKDMSGRPSTGLRAALGLTPGRTLTDANRFSPSVTAHGRAAPRAEIRVPKAQLCTASPGSGADAVLRELSTGQGCGFDIPVGAGRAVVVTSTYRCDLGFWTAALRRLGAEPRFTHDAKLPGVFLLTTADGDRGRLLHAFSISPGYGQDVTAAERGKPLFGGERLHLPGRGAAMLPLGVRAGGLRIAYATAEISEIADGRVASRALGDEAVVAVDGPARCTGAKVSVEGGRTLLRVGRREFTVHRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MZ63</accession>
    <name>A0A0F7MZ63_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptide-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_01240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014381.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_01240"/>
    <dbReference type="EnsemblBacteria" id="AKH81016">
        <property type="protein sequence ID" value="AKH81016"/>
        <property type="gene ID" value="AA958_01240"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_01240"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.271"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519066" evidence="1">
        <location>
            <begin position="29"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="2">
        <location>
            <begin position="77"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH81016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="526" mass="58117" checksum="B6E67069A3D3114E" modified="2015-07-22" version="1">MFFRSGPRRVAAALIPVSMLAGCGTLSASGDDERHIDVGTTSAPSTLDPAAAWDGSWELYRNVYQTLMHYAGTSTVPQPDAAKSCGFTGADSRTYRCKLREDLTFSNGNPLDAAAVKHSFDRVLAINAETGPAGLLDSLEKVETEGDRTVTFHLKRPDATFPFILAAPATSLVDPEEYPADKLAEPGTLVGSGPYTLASYKKGSVAELERNSSYTGDAELRNDSVSIRYFDDSDAMTDALKKGDIDVTYRGLPPDRVPELEKTADEKGSIALSRVVMPEIHYLVFNPEHEYADSLAVRQAVAQVIDRDALVRKVYGRTAEPLYSMIPRGITGHTTPFFDRYGEPDPEAAADTLETAGVTEPVPLTFWYTTDRYGSVTAREFEELERQLEDSGLFDVTVKGRKWEKFAAAYNKGEYPVFGRGWSPDFPDPDNYIAPFTGARNALGTPYENAEITEELLPESRRKADRAGVNEQFSRAQDILAEDARLLPLWQARQYIAADDDVAGVEWSLDASTIMRMWELYKKTSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MZ83</accession>
    <name>A0A0F7MZ83_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_01375</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_01375"/>
    <dbReference type="EnsemblBacteria" id="AKH81036">
        <property type="protein sequence ID" value="AKH81036"/>
        <property type="gene ID" value="AA958_01375"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_01375"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.302"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH81036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="130" mass="13007" checksum="B72935A11F80E531" modified="2015-07-22" version="1">MNPTYDFTGQVAFVTGAGSGMGLAAARASPPPGPHSCKHGVIGLTTSAALAYAPRGIRINAVCPRTIGTPMVSDMIAKGELDRAGAEADQPVNRLGTAGEIAQAVLWLCSPGAGFVVGVALPVDGGYTAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N079</accession>
    <name>A0A0F7N079_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dihydroorotase</fullName>
            <shortName evidence="5">DHOase</shortName>
            <ecNumber evidence="5">3.5.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">pyrC</name>
        <name evidence="7" type="ORF">AA958_03125</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 5">Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(S)-dihydroorotate + H2O = H(+) + N-carbamoyl-L-aspartate</text>
            <dbReference type="Rhea" id="RHEA:24296"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30864"/>
            <dbReference type="ChEBI" id="CHEBI:32814"/>
            <dbReference type="EC" id="3.5.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.3" evidence="5"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014696.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_03125"/>
    <dbReference type="EnsemblBacteria" id="AKH81336">
        <property type="protein sequence ID" value="AKH81336"/>
        <property type="gene ID" value="AA958_03125"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_03125"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.666"/>
    <dbReference type="OrthoDB" id="1319925at2"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00117"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004151">
        <property type="term" value="F:dihydroorotase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01317">
        <property type="entry name" value="DHOase_IIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00220_B">
        <property type="entry name" value="PyrC_classI_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004722">
        <property type="entry name" value="DHOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002195">
        <property type="entry name" value="Dihydroorotase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00483">
        <property type="entry name" value="DIHYDROOROTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="6">
        <location>
            <begin position="50"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="61"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="306"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH81336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="431" mass="45560" checksum="ADD669A37C40341B" modified="2015-07-22" version="1">MSKTLIRGAKILGGEARDVLIDGETVAEVAGPGVALPAGGAEVVEAAGRILLPGLVDLHTHLREPGREDSETVLTGTRAAAKGGFTAVHAMANTFPVADTAGVVEQVWRLGRESGYCDVQPVGAVTVGLEGKQLAELGAMHESAAGVVVFSDDGKCVDDAVIMRRALEYVKAFDGVVAQHAQEPRLTEGAQMNEGVVSAELGLGGWPAAAEESVIARDVLLAAHVDSRVHVCHLSTAGSVEIVRWAKSKGWRVTAEVTPHHLLLTDELVRSYDPVYKVNPPLRTETDVRALREALADGTIDCVATDHAPHPQEDKDCEWAAAAMGMVGLETALSVVQQTMVDTGLLDWPGVADRMSFRPAAIGRLDGHGRPVAPGEPANLTLLDPAYRGRVDPHSFVSRSRNTPYAGRELPGRVTHTFLRGRATLAGGEPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N088</accession>
    <name>A0A0F7N088_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Glutamine synthetase</fullName>
            <ecNumber evidence="6">6.3.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_07130</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + L-glutamate + NH4(+) = ADP + H(+) + L-glutamine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:16169"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the glutamine synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.2" evidence="6"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015380.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_07130"/>
    <dbReference type="EnsemblBacteria" id="AKH82030">
        <property type="protein sequence ID" value="AKH82030"/>
        <property type="gene ID" value="AA958_07130"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_07130"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1494"/>
    <dbReference type="OrthoDB" id="416474at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamate-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008147">
        <property type="entry name" value="Gln_synt_b-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027303">
        <property type="entry name" value="Gln_synth_gly_rich_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027302">
        <property type="entry name" value="Gln_synth_N_conserv_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03951">
        <property type="entry name" value="Gln-synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="SSF54368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00180">
        <property type="entry name" value="GLNA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00181">
        <property type="entry name" value="GLNA_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gln-synt_C" evidence="7">
        <location>
            <begin position="85"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH82030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="339" mass="36743" checksum="FF2322B86FEC5BE5" modified="2015-07-22" version="1">MSYKAEYIWIDGTLPTAKLRSKTKIVETGAEPPLWGFDGSSTNQAEGSSSDCVLKPVFTCPDPLRGGADVLVLCEVLDTDLSPHASNTRAELREVAGRFAGQEPVFGIEQEYTFFRGSRPLGFPENGFPAPQGGYYCGVGADEIFGREVVEAHLDNCLKAGLGLSGINAEVMPGQWEFQVGPLGPLEVADQLWVARWLLYRTAEDFGVSATLDPKPAKGDWNGAGAHTNFSTRRMREGYEAVVAACEALGEGDKPLAHVRAYGAGVETRLTGAHETAPWDEYSYGVSDRGASVRIPWQVEKDGKGYIEDRRPNANVDPYVVTRLMVDTCCTALEKAGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0B7</accession>
    <name>A0A0F7N0B7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_03520</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014764.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_03520"/>
    <dbReference type="EnsemblBacteria" id="AKH81406">
        <property type="protein sequence ID" value="AKH81406"/>
        <property type="gene ID" value="AA958_03520"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_03520"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.743"/>
    <dbReference type="OrthoDB" id="2063146at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002518934" evidence="2">
        <location>
            <begin position="24"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH81406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="122" mass="12468" checksum="C0A7D851D16CFF8B" modified="2015-07-22" version="1">MFLPLTIAVAVAALALAAWCGYAAVKDEPTKDWHFAGMAVVTVLALAQVAVGLVQLGRGEEADEGTAVFVAYLLAAGFAVPATGLLSLSERSRWGSATVAVGGFVLAVLQVRLHDIWAGSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0E0</accession>
    <name>A0A0F7N0E0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CRISPR-associated protein Cas5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_03705</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014799.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_03705"/>
    <dbReference type="EnsemblBacteria" id="AKH81441">
        <property type="protein sequence ID" value="AKH81441"/>
        <property type="gene ID" value="AA958_03705"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_03705"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.780"/>
    <dbReference type="OrthoDB" id="1706297at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043571">
        <property type="term" value="P:maintenance of CRISPR repeat elements"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021124">
        <property type="entry name" value="CRISPR-assoc_prot_Cas5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013422">
        <property type="entry name" value="CRISPR-assoc_prot_Cas5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010147">
        <property type="entry name" value="CRISPR-assoc_prot_CasD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09704">
        <property type="entry name" value="Cas_Cas5d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01868">
        <property type="entry name" value="casD_Cas5e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02593">
        <property type="entry name" value="CRISPR_cas5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH81441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="231" mass="25435" checksum="9BE9A9DC55DCB9B2" modified="2015-07-22" version="1">MSVLLLQLAGPLQSWGAASRFPRRSTESAPTKSGVIGLLAAAQGRPRTADLSDLAALRFGVRVDQPGTRVRDFHTAHHQVSGKAMPVTERFYLADAVFLAAVEGDRALIEELHAAVRAPHFLPFLGRRACPPARRLDLGVRHDTALETALLEHPWLASAWYREQTARTAPDQLPVLLDSAPDDPPGDVVADQPLSFDPRHRRYARRSVRHDAVARPVEVPEHDPMPLLESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0N6</accession>
    <name>A0A0F7N0N6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GCN5 family acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_00960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH80973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_00960"/>
    <dbReference type="EnsemblBacteria" id="AKH80973">
        <property type="protein sequence ID" value="AKH80973"/>
        <property type="gene ID" value="AA958_00960"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_00960"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.213"/>
    <dbReference type="OrthoDB" id="1390922at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH80973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="145" mass="15612" checksum="D68C6F4ABA1DDDBA" modified="2015-07-22" version="1">MPGMDDLHIRAAEPADVPAVLAFWKTAAEGTSVSDDEAGVAGLLERDPGALLLAERGGELAGTVIAGFDGWRCHLYRLAVHPGHRRRGVGTALLAAAEQRFAAFGGRRADAMVLNRNERAHHAWHAGGYVRQEQWSRWVKPLAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0V0</accession>
    <name>A0A0F7N0V0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_08405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015599.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH82250">
        <property type="protein sequence ID" value="AKH82250"/>
        <property type="gene ID" value="AA958_08405"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_08405"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1775"/>
    <dbReference type="OrthoDB" id="1101378at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="SSF50969"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519013" evidence="1">
        <location>
            <begin position="25"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="323" mass="35341" checksum="1F4F451585C5F28B" modified="2015-07-22" version="1">MRYVRTLGVTALAAALLGTVAASAAPAARPGGGHGTERDAPVVEAVAKLDRNSKWELVEKLPLDFETYHPQGMTRVGDRLFLSSVEVIEPPVRYPEPVDGYDRSPGRGVGHLFVLDLKGRLLEDLTLGEGDMYHPGGIDTDGRSVWVPVAEYRPDSAAVVYRVDVRTLKVTEEFRVDDHIGGVVPEPRTGKVHGVSWGSRTFYTWDRHGRQMQRRPNQSHFVDYQDCAYADSRKMLCTGITGFKNASGADFELGGIAAIDLRTFGIEHEVPVQLWSTGGHVATRNPVHLEALRGEGLRMWAAPDDGASPAGTELLVYETRPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N168</accession>
    <name>A0A0F7N168_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Rieske (2Fe-2S) protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_05580</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015110.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_05580"/>
    <dbReference type="EnsemblBacteria" id="AKH81756">
        <property type="protein sequence ID" value="AKH81756"/>
        <property type="gene ID" value="AA958_05580"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_05580"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1169"/>
    <dbReference type="OrthoDB" id="1681886at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="4">
        <location>
            <begin position="10"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH81756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="111" mass="11970" checksum="86F89B8856AD7770" modified="2015-07-22" version="1">MTDTTNATYVRACALSELEEDLPKRVDLAGTPVSVVLTGDEVFAIYDICSHANVSLSEGEVEDCQIECWLHGSTFDLRTGKPSGLPATRPVPVYPVKIEGDDVLVSVTQES</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-02-10" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N192</accession>
    <name>A0A0F7N192_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_05750</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015139.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH81786">
        <property type="protein sequence ID" value="AKH81786"/>
        <property type="gene ID" value="AA958_05750"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_05750"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1204"/>
    <dbReference type="OrthoDB" id="1195966at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010126">
        <property type="entry name" value="Esterase_phb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10503">
        <property type="entry name" value="Esterase_PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01840">
        <property type="entry name" value="esterase_phb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519021" evidence="2">
        <location>
            <begin position="31"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH81786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="312" mass="32437" checksum="EE5B6DFFB7E96FC5" modified="2015-07-22" version="1">MTRIRAALAAIASGLLITLAGIAAPASATAAQLVEVTDFGDNPGNLRMHIYVPDSAPASPAIVVAMHGCGGSGPGFAGSSEFISLADQHGFVVIYPTATKQTAMGNCFDVWSPESKTHGGGSDPASIVSMVGYAERQYGGDPARVFATGSSSGGMETQALLAVYPDVFKAGASFMGVPFTCFANEADFPPWTSQCVSGNLDRSPQQWGDAVRAAYPGYTGDRPRVQLWHGTADPLVPYQLHGEAVDQWTNVFGLSRTPTSTDQPQPGWTRDRFADSGGTVRVEAIGVQGAGHSLPMSGMARAAVSFFGIDGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N1C5</accession>
    <name>A0A0F7N1C5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">4-hydroxythreonine-4-phosphate dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.262</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pdxA</name>
        <name evidence="3" type="ORF">AA958_02460</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.1.262" evidence="3"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014586.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_02460"/>
    <dbReference type="EnsemblBacteria" id="AKH81223">
        <property type="protein sequence ID" value="AKH81223"/>
        <property type="gene ID" value="AA958_02460"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_02460"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.526"/>
    <dbReference type="OrthoDB" id="1414545at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050570">
        <property type="term" value="F:4-hydroxythreonine-4-phosphate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005255">
        <property type="entry name" value="PdxA_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30004">
        <property type="entry name" value="PTHR30004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04166">
        <property type="entry name" value="PdxA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00557">
        <property type="entry name" value="pdxA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH81223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="345" mass="36077" checksum="6D828A65067C2EFB" modified="2015-07-22" version="1">MTRPVLAVTLGDPVGIGPEITARTLAEVAGQTGHHGIAVGDAEALRRGARAAGLDTEVRAVSGFDAEPAGPGVIDVFDTGELGTDVPEWGKVDARAGRAAVTAIEVATRAALDGKVSGIVTGPINKEAIWKAGSKHLGHTEMLGELTGVTRQDTMFVVRNTAAEGHHLRIFFTTRHVALRTALDQITAERVGRSIREAVTALQVFGTEAPRLAVAAINPHGGENGAFGDEEIVHIAPAVEAARAEGLDVSGPVPADSVFHQGLVGRYDGVLSHFHDQGHIPAKTYDFDGTISVTVGLPILRTSVDHGTAFDIAGTGRADHGTMLSAYLAGVDYSPFAERIRRTYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N1P4</accession>
    <name>A0A0F7N1P4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Energy-dependent translational throttle protein EttA</fullName>
            <ecNumber evidence="7">3.6.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Translational regulatory factor EttA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ettA</name>
        <name evidence="10" type="ORF">AA958_09975</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">A translation factor that gates the progression of the 70S ribosomal initiation complex (IC, containing tRNA(fMet) in the P-site) into the translation elongation cycle by using a mechanism sensitive to the ATP/ADP ratio. Binds to the 70S ribosome E-site where it modulates the state of the translating ribosome during subunit translocation. ATP hydrolysis probably frees it from the ribosome, which can enter the elongation phase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer. Probably contacts ribosomal proteins L1, L5, L33 and S7, the 16S and 23S rRNA and the P-site containing tRNA(fMet).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="7">Associates with ribosomes and polysomes.</text>
    </comment>
    <comment type="domain">
        <text evidence="7">The P-site tRNA interaction motif (PtIM domain) probably interacts with the P-site tRNA(fMet) as well as the 23S rRNA.</text>
    </comment>
    <comment type="domain">
        <text evidence="7">The arm domain is inserted in the first ABC transporter domain. Probably contacts ribosomal protein L1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the ABC transporter superfamily. ABCF family. Translational throttle EttA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="7"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015847.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_09975"/>
    <dbReference type="EnsemblBacteria" id="AKH82505">
        <property type="protein sequence ID" value="AKH82505"/>
        <property type="gene ID" value="AA958_09975"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_09975"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2100"/>
    <dbReference type="OrthoDB" id="1112046at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045900">
        <property type="term" value="P:negative regulation of translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00847">
        <property type="entry name" value="EttA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022374">
        <property type="entry name" value="EttA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43858">
        <property type="entry name" value="PTHR43858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03719">
        <property type="entry name" value="ABC_ABC_ChvD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="2 7" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="6"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="322"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 8">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 8">
        <location>
            <begin position="354"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AKH82505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="554" mass="61544" checksum="F9CB96EEE90A8D95" modified="2015-07-22" version="1">MAEFIYTMRKARKAHGDKVILDNVTLNFLPGAKIGVVGPNGAGKSTVLKIMAGLEQPSNGDAFLSPGYSVGILLQEPPLNEEKTVLENVQEGVADTKGKLDRFNEIAEQMATDYTDELMEEMGKLQEELDHENAWDLDAQLEQAMDALGCPPGDWPVTNLSGGERRRVALCKLLLEAPDLLLLDEPTNHLDAESVAWLEQHLAQYAGTVVAITHDRYFLDNVAGWILELDRGRAFPYEGNYSTYLETKAARLKVEGQKDAKRQKRLKEELEWVRSNAKGRQAKSKARLARYEEMAAEAEKMRKLDFEEIQIPPGPRLGNVVVEVEKLSKGFGDKLLIDDLSFTLPRNGIVGVIGPNGAGKTTLFKMILGQEKPDSGSIRVGDTVNVSYVDQTRGNIDAKKTLWEVVSDGLDYINVGQVEMPSRAYVSAFGFKGPDQQKPAGVLSGGERNRLNLALTLKQGGNLLLLDEPTNDLDVETLSSLENALLEFPGCAVVITHDRWFLDRIATHILAYEGDSKWFWFEGNFESYEKNKIERLGPDAARPHRATYKKLTRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N1X0</accession>
    <name>A0A0F7N1X0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_00190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH80847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014214.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH80847">
        <property type="protein sequence ID" value="AKH80847"/>
        <property type="gene ID" value="AA958_00190"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_00190"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.43"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH80847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="117" mass="13075" checksum="2FB2F6E156284D24" modified="2015-07-22" version="1">MTLSWDIPRRRRDAYGGRGSAGEDPFGYGRERSEQYTVSARFVVARFGLPAEEEPRQIIGILLGAPDASDRLRATLTLKTLCRWHVATCEAIEAARVRFIEAARQHLGTAWSTSTSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N235</accession>
    <name>A0A0F7N235_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Activator protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_00715</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AfsR/DnrI/RedD regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH80932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014298.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_00715"/>
    <dbReference type="EnsemblBacteria" id="AKH80932">
        <property type="protein sequence ID" value="AKH80932"/>
        <property type="gene ID" value="AA958_00715"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_00715"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.163"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15831">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03704">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH80932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="256" mass="29242" checksum="E288686AB09F7369" modified="2015-07-22" version="1">MQYEILGPVRVVDSRGSRFVSAKKMQVLLVLLLIRARQVVSIDEAIAEIWGQNPPRRATAGIHVYISQLRKFLGEPGSRDNPILTRPPGYLLHLEDDEFDVDRFQELLHRGRLHLKEGRPEQAVTAFEDGLSLWRGPVLGDLCDGPIIAGFATWLEETRLEYLEWLIEAQLSLGLHRELIGRLSALTAEYPLRETFYRQLMLALCRSERQADALRTYQQARTRLNEELGLEPCRALRNLQQAILVADERLELPAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2D1</accession>
    <name>A0A0F7N2D1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cystathionine beta-synthase</fullName>
            <ecNumber evidence="4">4.2.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Beta-thionase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Serine sulfhydrase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">AA958_11655</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-homocysteine + L-serine = H2O + L,L-cystathionine</text>
            <dbReference type="Rhea" id="RHEA:10112"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:58161"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="4.2.1.22"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-homocysteine and L-serine: step 1/2.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.22" evidence="4"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016116.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_11655"/>
    <dbReference type="EnsemblBacteria" id="AKH82780">
        <property type="protein sequence ID" value="AKH82780"/>
        <property type="gene ID" value="AA958_11655"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_11655"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2451"/>
    <dbReference type="OrthoDB" id="1677960at2"/>
    <dbReference type="UniPathway" id="UPA00136">
        <property type="reaction ID" value="UER00201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004122">
        <property type="term" value="F:cystathionine beta-synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019343">
        <property type="term" value="P:cysteine biosynthetic process via cystathionine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005857">
        <property type="entry name" value="Cysta_beta_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001216">
        <property type="entry name" value="P-phosphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01137">
        <property type="entry name" value="cysta_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00901">
        <property type="entry name" value="CYS_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 11" id="KW-0129">CBS domain</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="13">
        <location>
            <begin position="335"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="149"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AKH82780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="462" mass="49239" checksum="48906A8750ECE074" modified="2015-07-22" version="1">MQYHESITDLVGNTPLVRLGRVTQGIRATVLAKVEYFNPGGSVKDRIALRMIEAAERSGALRPGGTIVEPTSGNTGVGLAMVAQQKGYKCIFVCPDKVSTDKINVLRAYGAEVVVCPTAVDPEHPDSYYNVSDRLVRETPGAWKPDQYSNPDNPASHYHSTGPELWTQTEGRITHFVAGIGTGGTISGTGRYLKEVSDGAVQIVGADPEGSVYSGGSGRPYLVEGVGEDFWPDAYDRGVADEIVAVSDKDSFRMTRRLAREEGLLVGGSCGMAVVAALRVAERLDENGVVVVLLPDSGRGYLSKIFNDDWMADYGFMEEAGAASVADVLRDKEGSMPSLVHMHPEETVGEAIEVLREYGVSQMPVVKPGAGHPDVMAAEVVGSIVERELLDALFTHKAELDHPLEQHMCPPLPQVGSGEPVADLVAVLERADAAVVLVEGKPTGVVSRTDLLAYLAKGAGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2F3</accession>
    <name>A0A0F7N2F3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_04425</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014914.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH81559">
        <property type="protein sequence ID" value="AKH81559"/>
        <property type="gene ID" value="AA958_04425"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_04425"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.932"/>
    <dbReference type="OrthoDB" id="1437290at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="4"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH81559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="195" mass="21878" checksum="40AED194F07ABE67" modified="2015-07-22" version="1">MGTEERRRQLLRIGAELFAERPFDDVWIEAVAERAGVSRGLLYHYFPTKRQFYAAVIRHEGEHLLRMTEPDPDTPVGRQVQQGLEAYLRYAEEHARGLRAFHRASATGDREIHEIHEQLLAEQERRIVAVLDAQAAAGLIDGPAPAALRLAVHGWLAFVTAAVLDWLERGEPSRAEVREVCTRALLGALEGARGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2P9</accession>
    <name>A0A0F7N2P9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3-oxoacyl-[acyl-carrier-protein] reductase</fullName>
            <ecNumber evidence="3">1.1.1.100</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_05125</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3R)-hydroxyacyl-[ACP] + NADP(+) = a 3-oxoacyl-[ACP] + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:17397"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="1.1.1.100"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.100" evidence="3"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015034.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_05125"/>
    <dbReference type="EnsemblBacteria" id="AKH81679">
        <property type="protein sequence ID" value="AKH81679"/>
        <property type="gene ID" value="AA958_05125"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_05125"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1077"/>
    <dbReference type="OrthoDB" id="1601931at2"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011284">
        <property type="entry name" value="3oxo_ACP_reduc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="2 3" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="145"/>
        </location>
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        <location>
            <begin position="9"/>
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        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
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        <location>
            <begin position="145"/>
            <end position="149"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
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        <source>
            <dbReference type="PIRSR" id="PIRSR611284-1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR611284-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU366074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH81679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="239" mass="25374" checksum="C0A4202E4073F5C7" modified="2015-07-22" version="1">MSRSVLVTGGNRGIGLDITRAFAEAGDKVAFTYRSGEPPAALVELGCLPVKCDITDTEQVDRAYKEVEEAHGNVEVLVANAGITKDQLLMRMSEEDFVSVLDTNLTGTFRVVKRANRGMLRARKGRVVLISSVVGLMGSPGQSNYAASKAALVGFARSLARELGSRNITFNVVAPGFVETDMTRVLSAERQAEIAAQVPLGRYARPEDVAAAVRFLASDDASYITGAVLPVDGGLGMGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2R1</accession>
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    </gene>
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        <name type="scientific">Streptomyces sp. CNQ-509</name>
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            <taxon>Actinobacteria</taxon>
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        </lineage>
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        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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    <dbReference type="Proteomes" id="UP000034283">
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SSF56784"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
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        <location>
            <begin position="309"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="364" mass="36699" checksum="26E0D92DE803D928" modified="2015-07-22" version="1">MIEPWISPVRGAAAVTSQPVRTRTDVCAEPLCTAYDTALLDLDGVVYIGGVAVEHAAGALSGAGERGMRLAYVTNNASRPAAVVAGQLTAMGVPAEPADVITSAQAVARLVAEEVPPGARVLAVGGEGLYGPLREHGLLVVESADDDPAAVVQGHGGPAMPWGRLMEAAFAVQRGVPWFASNADLTIPTPRGIAPGNGAALEVVRLATGAEPRVAGKPLPPMHRETIIRTGARRPLVVGDRLDTDIEGAYNGGVDALLVLTGVTGAAGLLAAEPRHRPAYVAADLRGLAAAQPEVAVAGGDGEGVVARCGGWSASAGGTEPGLRLDGEGQPLDGLRALCAAAWTYAGEGSCGLDPGKALARLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2V6</accession>
    <name>A0A0F7N2V6_9ACTN</name>
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            <fullName evidence="5 7">L-ectoine synthase</fullName>
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        </alternativeName>
    </protein>
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        <name evidence="7 8" type="primary">ectC</name>
        <name evidence="8" type="ORF">AA958_05310</name>
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    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the circularization of gamma-N-acetyl-alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6-tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>(2S)-4-acetamido-2-aminobutanoate = H2O + L-ectoine</text>
            <dbReference type="Rhea" id="RHEA:17281"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58515"/>
            <dbReference type="ChEBI" id="CHEBI:58929"/>
            <dbReference type="EC" id="4.2.1.108"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Amine and polyamine biosynthesis; ectoine biosynthesis; L-ectoine from L-aspartate 4-semialdehyde: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the ectoine synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.108" evidence="4 7"/>
    <dbReference type="EMBL" id="CP011492">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015067.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AKH81713">
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        <property type="gene ID" value="AA958_05310"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_05310"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1114"/>
    <dbReference type="OrthoDB" id="1928636at2"/>
    <dbReference type="UniPathway" id="UPA00067">
        <property type="reaction ID" value="UER00123"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033990">
        <property type="term" value="F:ectoine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019491">
        <property type="term" value="P:ectoine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06978">
        <property type="entry name" value="cupin_EctC"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01255">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
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        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SSF51182"/>
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    </dbReference>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH81713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="132" mass="15024" checksum="2C22C8C39664CB77" modified="2015-07-22" version="1">MIVRSFKELEGTDRHIKSASGTWESKRIVLAKERVGFSLHETVLYAGTETSMWYANHIEAVVCVEGEAELTNDETGEKHAITPGTMYLLDGHERHTMRIKQDFRCICVFNPPVTGREDHDENGVYPLLTEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2W3</accession>
    <name>A0A0F7N2W3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_05385</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_05385"/>
    <dbReference type="EnsemblBacteria" id="AKH81723">
        <property type="protein sequence ID" value="AKH81723"/>
        <property type="gene ID" value="AA958_05385"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_05385"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1129"/>
    <dbReference type="OrthoDB" id="1873445at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13187">
        <property type="entry name" value="Fer4_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="34"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="64"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH81723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="96" mass="9895" checksum="46E0DDAED72E85AD" modified="2015-07-22" version="1">MNARTRTGAPPSAAEHTAARAADGLPEPRPAEVPALTLTVSDRCTGCGACLLTCPVHAVRPRGGALFVRADLCTGCLECVEVCPADAIDEAPEERP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2Z5</accession>
    <name>A0A0F7N2Z5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_02515</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014595.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_02515"/>
    <dbReference type="EnsemblBacteria" id="AKH81232">
        <property type="protein sequence ID" value="AKH81232"/>
        <property type="gene ID" value="AA958_02515"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_02515"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.538"/>
    <dbReference type="OrthoDB" id="1584669at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="69"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="184"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="238"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="65"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH81232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="270" mass="29555" checksum="968B8BAEBC6EB4A6" modified="2015-07-22" version="1">MGRHMRNLFVAGCVLLWLLPLYLLIVNALTPAEEYTGSVDWTPQGFAIFDNLKTAWVDAGIGDGFASSMLYAVVCGAVAVVVAAMAAFAVIVLPIPRPALWFWAIFSGTLFPLQMFLAPLFGMYADANLYDTRLGLMLVYAAWAIPFAFFLIRNQMTTMPPEITEAAMLDGASMRRIFWRIHVPLMRSGLGAAFIFQFTAVWNDLLFGITLSRSPEIQPVMAALNSLNQAYSSAGPPVILAGAFIVSLPTLLVFLVFRGLFLRGITASAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3M6</accession>
    <name>A0A0F7N3M6_9ACTN</name>
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        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_03525</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014765.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_03525"/>
    <dbReference type="EnsemblBacteria" id="AKH81407">
        <property type="protein sequence ID" value="AKH81407"/>
        <property type="gene ID" value="AA958_03525"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_03525"/>
    <dbReference type="OrthoDB" id="1956639at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="122"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH81407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="153" mass="16433" checksum="961D842522055BB8" modified="2015-07-22" version="1">MAEQRQAAGEPRESGHTGLSSGPGRLILALYGVFAVGATSRAVYQLSTEFGKAPLAYVLSALAAVVYVFITVALARGGETARRLALVCITAELIGVLAIGTWTEVQPSEFPDQTVWSDYGRGYLFLPVILPVIGLWWLRKQSSRARPEGPSPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N405</accession>
    <name>A0A0F7N405_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_07485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015449.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH82099">
        <property type="protein sequence ID" value="AKH82099"/>
        <property type="gene ID" value="AA958_07485"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_07485"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1569"/>
    <dbReference type="OrthoDB" id="1450979at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="354"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="398" mass="43668" checksum="83968C3C676007D6" modified="2015-07-22" version="1">MQEERCTVPTPPGTRLLHIGPHKTGTTALQAAFHQARDTLREHGVVYAGPGRQAKDPAVAIARKDPTAAEREPWEAFCREAAEAGDLRFFASSEFFATASADAARRAVKELAGAGGVSGVHVVVTLRPLRKIMPSHWQQYVKHGLCESYETWLDAMLRKPPYEEPTPDFWHLQRHDELIERWAAAAGPENVTAVVVDEARPLWQFRVFEQLLDLPEEVLQPQESGGNSSLTQSEAELLLQLNRKLRDRNWSTWRQGKVIREGVVPRLQAYEPAPDEPRITTPPWAEEAVAEVADRVVAGIAASGTRVVGDLDALTRRPSSPAEPVTAREIPTEAATEAVLGGILASAELAAKTAAPPASAPPEAPTARTALEDRPVRNVPVKDLVRVVCRRAVRRMRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N435</accession>
    <name>A0A0F7N435_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glutathione S-transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_04690</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014962.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_04690"/>
    <dbReference type="EnsemblBacteria" id="AKH81607">
        <property type="protein sequence ID" value="AKH81607"/>
        <property type="gene ID" value="AA958_04690"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_04690"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.988"/>
    <dbReference type="OrthoDB" id="1997747at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009297">
        <property type="entry name" value="DUF952"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34129">
        <property type="entry name" value="PTHR34129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06108">
        <property type="entry name" value="DUF952"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH81607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="110" mass="12213" checksum="24DD7444E4006419" modified="2015-07-22" version="1">MTTELWHITERARWEAARRTGVYEQSTRGRTLAEEGYIHCSLPHQLAPVAQALYGTRPEEDPVVLVIDAGRLSAPVRFEAAEPGGEEFPHVYGPIPADAVVRADPWPAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N455</accession>
    <name>A0A0F7N455_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cell division protein SepF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">sepF</name>
        <name evidence="7" type="ORF">AA958_04815</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer. Interacts with FtsZ.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="5">Localizes to the division site, in a FtsZ-dependent manner.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SepF family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014982.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_04815"/>
    <dbReference type="EnsemblBacteria" id="AKH81627">
        <property type="protein sequence ID" value="AKH81627"/>
        <property type="gene ID" value="AA958_04815"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_04815"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1014"/>
    <dbReference type="OrthoDB" id="2064885at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043093">
        <property type="term" value="P:FtsZ-dependent cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cell_div_SepF"/>
    </dbReference>
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        <property type="entry name" value="Cell_div_SepF/SepF-rel"/>
    </dbReference>
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        <property type="entry name" value="SepF-like_sf"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SepF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 5 7" id="KW-0132">Cell division</keyword>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0717">Septation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH81627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="148" mass="16143" checksum="1A627865F5700CF8" modified="2015-07-22" version="1">MGSVRRASAWLGLVDDNEDERYYDGYEDDSSDTPQGDAAWTTDPRVRVASQVAQEKGRRIATVSPDGFRDARGIGELFREGVPVIVNLTMLEAADAKRVVDFAAGLTFGLRGSIERVATRVFLLTPAEYAIVPGEVPRSTQGGFFNQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N470</accession>
    <name>A0A0F7N470_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4240 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_15865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_15865"/>
    <dbReference type="EnsemblBacteria" id="AKH83440">
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        <property type="gene ID" value="AA958_15865"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_15865"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3342"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025334">
        <property type="entry name" value="DUF4240"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14024">
        <property type="entry name" value="DUF4240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4240" evidence="1">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="191" mass="20941" checksum="FDBD44CB08D90C6E" modified="2015-07-22" version="1">MDIDRFWHLVESARSSAAADGVPFDEALVGLLAGLPRQEILAYAERFGEVHGALYRWDVWAAAYLIGGGCSDDSFMAFRAGVISLGREWYERAVAAPDSLAEHPAVAEAARDGHDEVLFHEEVNYAAGAAFERLTGSRDAFHEAWAEYRPADGEAGTAPDMGEDFDFDDDGEMQKRLPRLARLYLGAADRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N487</accession>
    <name>A0A0F7N487_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD superfamily hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_08100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015548.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_08100"/>
    <dbReference type="EnsemblBacteria" id="AKH82198">
        <property type="protein sequence ID" value="AKH82198"/>
        <property type="gene ID" value="AA958_08100"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_08100"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1707"/>
    <dbReference type="OrthoDB" id="1501962at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024197">
        <property type="entry name" value="UCP030802"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF030802">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH82198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="269" mass="28856" checksum="E31909E595C39A08" modified="2015-07-22" version="1">MTIIASDLDRTLIYSPAALALAVPDAAAPRLLCVEVYEGRPLSFLTETAATLLADLAGRVHFVPVTTRTREQYGRVRLPGPPPRYAICANGGHLLVDGEADAGWRARVGRELAVGSAPLAEVRAHLERAADPAWLRKLRTAEDLFAYLVVERAAVPEEWLKELGEWAEGRGWSVSAQGRKVYAVPRPLTKSAAVAEVVRRVGEPAADGVLAAGDSLLDTDLLLAADRAWRPGHGELATRGWTAPHVTALDERGVAAGEEILRQMAGCLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4A6</accession>
    <name>A0A0F7N4A6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Peptidase S8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_05165</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_05165"/>
    <dbReference type="EnsemblBacteria" id="AKH81687">
        <property type="protein sequence ID" value="AKH81687"/>
        <property type="gene ID" value="AA958_05165"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_05165"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1085"/>
    <dbReference type="OrthoDB" id="923655at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519034" evidence="6">
        <location>
            <begin position="34"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S8" evidence="7">
        <location>
            <begin position="171"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH81687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="507" mass="52594" checksum="D069CCCFAFF2D218" modified="2015-07-22" version="1">MTHLRPRGRRLLAVPLGLTLAAALGLLPGAASAASAPEPGGSAGAAAGEKLSYVVNTETDDKTIARVKDAIADADGSVVVTHKKIGVVVAHSTNPDFAAELRGVRGVRSAGASRTAPLTPSGTLETSAPEVYKGAAKARSQDPGVEPLEKEQWDLPAIGADKAHKVSTGSRDVTVGVIDTGVDDTHPDLKANFSAKQSANCVGGVADTTEGAWRPYDPAGDYHGTHVAGEIAAARNGVGVAGVAPGVQVASLKVSEPDTALFYAEAVVCAFVFAGDNGIEITNNSYYVDPWLYNCLDDPDQRAIVEAVNRASLYAMGKGTLHLAAAGNSNDDLASDEIVDDSSPNDTTPLERTIDPSECWDVPTQLPGIVTVAATGVNDDKSYYSSYGQKVVDVAAPGGDGYQIPDTPSKNGRILSTLPENKYGWLQGTSMATPHAAGVAALIKSKHPRVSPTALHMLMKSQADNPGCPEFYDPDGNGVEDSTCTGDKRTNAFYGAGIVDAYDAVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4G8</accession>
    <name>A0A0F7N4G8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alkylhydroperoxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_08605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015631.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_08605"/>
    <dbReference type="EnsemblBacteria" id="AKH82283">
        <property type="protein sequence ID" value="AKH82283"/>
        <property type="gene ID" value="AA958_08605"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_08605"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1815"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004675">
        <property type="entry name" value="AhpD_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00778">
        <property type="entry name" value="ahpD_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMD" evidence="1">
        <location>
            <begin position="20"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="151" mass="16438" checksum="03CC3B8E9654A2AB" modified="2015-07-22" version="1">MQPRMQNPAMILDAMQPVGDIYKAAFSGGVPKTTLDLVHLRASQINGCSSCVDSGARNARKSGETDERLASVAAWRDAPYFTDEERAALALTEATTRMADRSDPVPDAIWDEAAKHYDEKGLAALVLTIAVTNLFNRLNATTKQVPQDWSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4I8</accession>
    <name>A0A0F7N4I8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GSDH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_08615</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015632.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_08615"/>
    <dbReference type="EnsemblBacteria" id="AKH82284">
        <property type="protein sequence ID" value="AKH82284"/>
        <property type="gene ID" value="AA958_08615"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_08615"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1817"/>
    <dbReference type="OrthoDB" id="567019at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012938">
        <property type="entry name" value="Glc/Sorbosone_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011041">
        <property type="entry name" value="Quinoprot_gluc/sorb_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07995">
        <property type="entry name" value="GSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50952">
        <property type="entry name" value="SSF50952"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519116" description="GSDH domain-containing protein" evidence="1">
        <location>
            <begin position="30"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="GSDH" evidence="2">
        <location>
            <begin position="55"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH82284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="485" mass="52053" checksum="7CE83B2DFC0AC70D" modified="2015-07-22" version="1">MSRTIKPLSLVAALTVLPALLVATPSAVAAPEPTGTSAPNAAGFTRTALVDSDLADPFELAVTPDGRVLYAQRTGELKIIDQETREVTTAYDFDYPLEFTTQSDGLIGLTLDPAFAQNHRLYVMHSDKAEKKVNISRFTLKGDRLDPASQEVLLSIPTWRGEGRANVHMGGSLAFDSKGNLYAATGDNTDPFESDGFTPTDERAGRHAWDAQATAANTNDLRGKVLRIKPTKGGTYTVPKGNLFRKGEKKTRPEIYAMGFRNPFRISVDPATDALMVGDYGPDSGTANENRGPAGIVEYNLISQAGNMGWPYCVGNNIPFNDYDFATGTSGGKFDCAAPVNNSPNNTGRTQLPPATAAQVWYSYAASAEFPQLGSGGGGPMGGPAYDFDPDLDSATKFPEAYDGKWFNYELTRKWFKTFSYADGKLESIDPVFEGMSWIQPFDAEFGPDGSLYVIDFGAGSGVGRGSTNTDAGIYRIDYAAGAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4K1</accession>
    <name>A0A0F7N4K1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_12485</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016251.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_12485"/>
    <dbReference type="EnsemblBacteria" id="AKH82916">
        <property type="protein sequence ID" value="AKH82916"/>
        <property type="gene ID" value="AA958_12485"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_12485"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2623"/>
    <dbReference type="OrthoDB" id="336531at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005693">
        <property type="entry name" value="Mce"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024516">
        <property type="entry name" value="Mce_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11887">
        <property type="entry name" value="Mce4_CUP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00996">
        <property type="entry name" value="Mtu_fam_mce"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="MlaD" evidence="2">
        <location>
            <begin position="38"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Mce4_CUP1" evidence="3">
        <location>
            <begin position="126"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH82916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="431" mass="45891" checksum="BC1070D570976A06" modified="2015-07-22" version="1">MSRLETTGRRTAGLVFLLVMALLVWLSVAVYQKEFTDTATVTVETGSVGNEMHPYAEVKMRGVVVGEVREISAENGGRTARLTLALDPGQLDRIPADVSAQMLPTTLFGERFVSLVPPADGGTAGETLAAGGVIPQDRSENAIELEQVLDNVMPLLTAVKPAKLSATLTAMADALDGRGKKLGDTLVELDEHLRKLNPHLPTLNRDIRELVEFGHLYADTVPDLTKALRDATTTSGTIAEKAQDLGGLYGTLTTTSQDLDTFLEQNRENIIRLSADSRPTVEKMAEYAPSFPCTLRTLADFVPVMDKALGKGTAEPGLHVDVEVLPARGKYVPGRDAPRFDAGGGPRCYGVPYTGAPARSGTAAGRPQSAKTLTTAPATDEQALGLPNSPAENQLVNELLAAGMESPPDDLPDWSSVLAGPVFRGTEVRLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4L4</accession>
    <name>A0A0F7N4L4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycerophosphodiester phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_05785</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015145.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_05785"/>
    <dbReference type="EnsemblBacteria" id="AKH81792">
        <property type="protein sequence ID" value="AKH81792"/>
        <property type="gene ID" value="AA958_05785"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_05785"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1211"/>
    <dbReference type="OrthoDB" id="1542724at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="SSF51695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519120" evidence="1">
        <location>
            <begin position="33"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="GP-PDE" evidence="2">
        <location>
            <begin position="45"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH81792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="308" mass="33065" checksum="3AE59B4F5C243E88" modified="2015-07-22" version="1">MPSRTLTRASGALTALAGLVLTAAATSATATAAEPAADSDSAAPVVTVAHRGASAYAPENTLAAVDAARDMGIDWVENDVQRSKDGELVIMHDDTLARTTNVEELFPDRAPWKVSDFTWKEISTLDAGSWKGEEWAGTRVPTLDQYMKRVTQNRQKLVLEIKKPELYPGIEKEILAELRKSGWLSRAAVKHKLVVQSFGADSIKTVHELRPDVKTGFLGAPAVADLPEYATFSDQINSNHGTMSAEYYAAVHALKGPHGKQLESYTWTVDDPARAVQLAEWGADGIITNKPDLIAEALAGAGFGVAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4R8</accession>
    <name>A0A0F7N4R8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_09105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015706.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_09105"/>
    <dbReference type="EnsemblBacteria" id="AKH82359">
        <property type="protein sequence ID" value="AKH82359"/>
        <property type="gene ID" value="AA958_09105"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_09105"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1918"/>
    <dbReference type="OrthoDB" id="1693430at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="28"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="283" mass="31851" checksum="22153ED3CF647B90" modified="2015-07-22" version="1">MSHYLRSHETDTTAGSYDSPRTFYGAELRRLREDAGLSQERLSERVFCSPAYIAHFESCVRLPQEEISKLLDDLFGTGEHLQRLCLLARRSSYPDYFTDAADLETVATHLYDHAPQLVPGLLQTREYARAIYVATAPWMPDDVIEKHVQARLERQQLLRAPEAPKIWAVLHEAVLRTAFGGPEVAAKQLRHIADLARARRIVVQVLPFEAAAQGFMSGMARIMKFAEGPSMVYEEGTHRGNLIDDPALVARYQASYDLIRATALSPMASLEMLESVAEGYERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4S8</accession>
    <name>A0A0F7N4S8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_09365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015749.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_09365"/>
    <dbReference type="EnsemblBacteria" id="AKH82403">
        <property type="protein sequence ID" value="AKH82403"/>
        <property type="gene ID" value="AA958_09365"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_09365"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1976"/>
    <dbReference type="OrthoDB" id="954654at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021447">
        <property type="entry name" value="DUF3097"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11296">
        <property type="entry name" value="DUF3097"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="274" mass="30118" checksum="D3D3200181BF0914" modified="2015-07-22" version="1">MRRYDTDLTPPWKKPQQPAPEVPAEPDLVVEEVATGFCGAVIRTEKTAEGPTVTLEDRFGKHRVFPLTPRGFMIDGRVVTLVRPGRTRPAGPLLSASGSIAVRDHTARVARAGRIYVEGRHDAELVERVWGHDLRVEGVVVEYLEGVDDLPSVVSAFAPGPDTRLGVLVDHLVPGTKEWRIAESVTSTHALVVGHPYVDVWEAVKPASVGIAAWPRIPRGEDWKTGVCRELGWPPDTGAAWRRILDSVRTYRDLEPALLGRVEELIDFVTAPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N501</accession>
    <name>A0A0F7N501_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Chaperone protein ClpB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">clpB</name>
        <name evidence="13" type="ORF">AA958_17635</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homohexamer. The oligomerization is ATP-dependent.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homohexamer; The oligomerization is ATP-dependent.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the ClpA/ClpB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017029.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_17635"/>
    <dbReference type="EnsemblBacteria" id="AKH83725">
        <property type="protein sequence ID" value="AKH83725"/>
        <property type="gene ID" value="AA958_17635"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_17635"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3714"/>
    <dbReference type="OrthoDB" id="44062at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017730">
        <property type="entry name" value="Chaperonin_ClpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028299">
        <property type="entry name" value="ClpA/B_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
        <property type="entry name" value="SSF81923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03346">
        <property type="entry name" value="chaperone_ClpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51903">
        <property type="entry name" value="CLP_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00871">
        <property type="entry name" value="CLPAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 10" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 11" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="Clp R" evidence="12">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="414"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AKH83725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="868" mass="94971" checksum="DB1771A40F399A5E" modified="2015-07-22" version="1">MDAELTNKSQEAIAGANSRAVSGGNPDITPVHLLLALLDVADNENLQDLLAAVDADQAAVRSGAEALLGGLPSVQGATVSPPRADRELLAVVADAAERARKLGDQYVSTEHLLIGVAAEGGAAKELLKKQGASAKALVQAFEKIRGDRRVTTKNPEGTYQALGKFGTDLTAAARDGKLDPVIGRDQEIRRVVQVLSRRTKNNPVLIGEPGVGKTAVVEGLAQRIVKGDVPESLKNKRLVALDLGAMVAGAKYRGEFEERLKTVLAEIRESEGQVITFIDELHTVVGAGAGGESAMDAGNMLKPMLARGELRMVGATTLDEYRERIEKDAALERRFQQVLVAEPTVEDTIAILRGLKGRYEAHHKVVIADSALVAAATLSDRYITSRFLPDKAIDLVDEAASRLRMEIDSSPTEIDELQRAVDRLRMEELALKNESDVASRERLERLQRDLADKEEELRGLTARWEKEKQGLNRVGELKERLDELRGTAERAQRDGDFDTASKLLYGELPALERELEEASAAEEEVKRDTMVKEEVGSDDIADVISSWTGIPAGRLLEGETQKLLRMEEELGRRLIGQDVAVRAVSDAVRRTRAGIADPNRPTGSFLFLGPTGVGKTELAKALADFLFDDERAMVRIDMSEYGEKHSVSRLVGAPPGYVGYEEGGQLTEAVRRRPYSVILLDEMEKAHTEVFDILLQVLDDGRLTDGQGRTVDFRNTILILTSNLGSTFLVDPMIKDEQKREGVLETVRKVFRPEFLNRLDDLVVFNALGGDQLKRIAAIQLAHLQERLSERRLTLEVSDAALAWLARLGVPEDEPEPDLSYGARPLRRLVQTAIGDQLAKEILAGEVRDGDTVWVDVLGDQLLVGAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N539</accession>
    <name>A0A0F7N539_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase</fullName>
            <ecNumber evidence="7">6.3.2.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Meso-A2pm-adding enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Meso-diaminopimelate-adding enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">UDP-MurNAc-L-Ala-D-Glu:meso-diaminopimelate ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">UDP-MurNAc-tripeptide synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">UDP-N-acetylmuramyl-tripeptide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">murE</name>
        <name evidence="13" type="ORF">AA958_06555</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + meso-2,6-diaminoheptanedioate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate</text>
            <dbReference type="Rhea" id="RHEA:23676"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
            <dbReference type="ChEBI" id="CHEBI:83905"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="7 8">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="7">Carboxylation is probably crucial for Mg(2+) binding and, consequently, for the gamma-phosphate positioning of ATP.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the MurCDEF family. MurE subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.13" evidence="7"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015279.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_06555"/>
    <dbReference type="EnsemblBacteria" id="AKH81927">
        <property type="protein sequence ID" value="AKH81927"/>
        <property type="gene ID" value="AA958_06555"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_06555"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1368"/>
    <dbReference type="OrthoDB" id="1861122at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008765">
        <property type="term" value="F:UDP-N-acetylmuramoylalanyl-D-glutamate-2,6-diaminopimelate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="P:regulation of cell shape"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Mur_ligase_N"/>
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        <property type="entry name" value="MurE/MurF_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005761">
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    </dbReference>
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        <property type="entry name" value="Mur_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63418">
        <property type="entry name" value="SSF63418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01085">
        <property type="entry name" value="murE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 7 8" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 7 8" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6 7 8" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 7 8" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase" evidence="10">
        <location>
            <begin position="52"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_M" evidence="12">
        <location>
            <begin position="140"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_C" evidence="11">
        <location>
            <begin position="374"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="UDP-MurNAc-L-Ala-D-Glu binding" evidence="7">
        <location>
            <begin position="189"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Meso-diaminopimelate binding" evidence="7">
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            <begin position="449"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="531"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Meso-diaminopimelate recognition motif" evidence="7">
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            <begin position="449"/>
            <end position="452"/>
        </location>
    </feature>
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        <location>
            <position position="59"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:83900"/>
        </ligand>
    </feature>
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        <location>
            <begin position="142"/>
            <end position="148"/>
        </location>
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        </ligand>
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        <location>
            <position position="216"/>
        </location>
        <ligand>
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        </ligand>
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        <location>
            <position position="224"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:83900"/>
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        <location>
            <position position="425"/>
        </location>
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            <dbReference type="ChEBI" id="CHEBI:57791"/>
        </ligand>
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        <location>
            <position position="505"/>
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        <ligand>
            <name>meso-2,6-diaminoheptanedioate</name>
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        </ligand>
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        <location>
            <position position="509"/>
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        <ligand>
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        <location>
            <position position="256"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
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        <source>
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        </source>
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        </source>
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        </source>
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        </source>
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            <dbReference type="Pfam" id="PF08245"/>
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        <source>
            <dbReference type="EMBL" id="AKH81927.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="555" mass="56654" checksum="7E3E55F2AA796497" modified="2015-07-22" version="1">MPHPDQSPQEASGAPAKHPGAPRPAEVDPVPLTELADRLGTGVTGEAGGVTVTGITHDSRAVRPGDVYAALPGARLHGADFAAQAADLGAAAVLTDPAGLERAAGTGLPVLVVGDPRGRMGELAAAVYGEPGRDLLQLGVTGTSGKTTTAYLVEGGLRAAAEKDGAGLTGLIGTVEMRIGDERLKSERTTPEATDLQALFAVMRQRGVASVAMEVSSHALVLGRVDGVLFDVAVFTNLSPEHLDFHTDMEDYYRAKAQLFTPARSRAGVVNIDDEYGMRLAEEAAAPEGGGSYPVTTYSAEGHPDADWRAEDVEIGVLGSTFTAVGPGGIAIPAEAPLPGTFNVSNTLAAIAALVTAGIDPATAAGGVAAVPGVPGRLERVDAGQGYLAVVDYAHKPDALESVLWALRKVTENRLHVVVGCGGDRDPHKRGPMGAAAARLADTAVLTSDNPRSEDPLAILAAMLAGAAEVPVYERGDVLVEADRAGAIAIAVARAGAGDTVLIAGKGHEQGQDTAGVVRPFDDRDELRRAIRERAGAGSADPGHPDSAEPAGGVR</sequence>
</entry>
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    <accession>A0A0F7N5A2</accession>
    <name>A0A0F7N5A2_9ACTN</name>
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            <fullName evidence="1">DUF397 domain-containing protein</fullName>
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        <name evidence="2" type="ORF">AA958_14160</name>
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    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="14"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="90" mass="9608" checksum="09B4B96A6A188849" modified="2015-07-22" version="1">MPDYVIPDASILNGWRKSSYSGNEGGSCLEVLAGYPVGVPVRDSKDPRGPALIFQADAWSSFIAALRSGEFVAEYRLSPALTEQSAIASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5K6</accession>
    <name>A0A0F7N5K6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">1,3-beta-glucanase</fullName>
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    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_07500</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
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        <property type="gene ID" value="AA958_07500"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_07500"/>
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    <dbReference type="OrthoDB" id="1046649at2"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="GH16"/>
    </dbReference>
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        <property type="entry name" value="TAT_signal"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519283" evidence="2">
        <location>
            <begin position="33"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="3">
        <location>
            <begin position="37"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH82102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="322" mass="33713" checksum="E6ABE8F04857B64D" modified="2015-07-22" version="1">MHATRIRWRRSLLGAVAAIAAVSALTLPSATAGEDAGDKAAASGPAPLAEVFRDDFDGAAGSPPSAANWIVDTGTSYPGGPANWGTGEIQTYTDSPENLQKDGNGNLTITPRRNGSGGWTSARIETQRTDFQAPAGGLMRIEARIQMPNVTGAEALGYWPAFWTLGDAYRGNYWNWPGIGEFDIMENVNGVDSVWGVLHCGTAPGGPCNENNGLGASRACPGGSCQSGFHEYALELDRSGPVEELRWYVDGQQYHSVNADQVGAETWANLAHHGHFLLLNVAMGGAFPDGVAGHATPTDATRPGVPMTVDYVSVEQSGGAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5L2</accession>
    <name>A0A0F7N5L2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP-dependent helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_18490</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017162.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_18490"/>
    <dbReference type="EnsemblBacteria" id="AKH83865">
        <property type="protein sequence ID" value="AKH83865"/>
        <property type="gene ID" value="AA958_18490"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_18490"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3881"/>
    <dbReference type="OrthoDB" id="58588at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024590">
        <property type="entry name" value="HrpA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010222">
        <property type="entry name" value="RNA_helicase_HrpA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11898">
        <property type="entry name" value="DUF3418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01967">
        <property type="entry name" value="DEAH_box_HrpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="87"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="2">
        <location>
            <begin position="278"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH83865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="1337" mass="150132" checksum="78FD4D30B02217B3" modified="2015-07-22" version="1">MSTSATPSLADLGARLSALTLRDEQRLGRRLDGARRVRKPEARAAVLAEIAAAVDAAELTAERRRAAVPPVSYPQELPVSQKKDDILAAIRDHQVVIVAGETGSGKTTQIPKICLELGRGVRGLIGHTQPRRIAARTVAERVAEELRTPLGEAVGWKVRFTDQVGGDTLVKLMTDGILLAEIQTDRELRQYDTIIIDEAHERSLNIDFLLGYLARLLPRRPDLKVVITSATIDPERFSRHFGDAPIVEVSGRTYPVEVRYRPLLDEGAEDSDRDQISAICDAVDELQAEGDGSGDILVFLSGEREIRDTADALAKQRLRNTEVLPLYARLSHAEQHRVFQRHGSRRVVLATNVAETSLTVPGIRYVIDTGFARISRYSHRTKVQRLPIEPISQASANQRKGRCGRLADGICIRLYAEEDFLARPEFTDAEILRTNLASVILQMTAAGLGDIEKFPFIDPPDSRNIKAGVQLLEELHALDTAQKDPKKRLTQTGRKLAQLPVDPRLARMVLEAERNGCVREVMVIASALSIQDPRERPADKQQQADQHHARFRDESSDFVTFLNLWTYVREQQKALSSSAFRRMCKREFLNYLRIREWQDIYSQLRTIARGMGIHPADQDAAPDLVHQSLLAGLLSHIGLKNAGGEGGREGAAKNEYLGARSAKFAVFPGSALFKKPPRWIMSAELVETSRLWARVNAKVEPDWIEPLAQHLVKRTYSEPHWEKDQAAVMAYERVTLYGVPLVARRSVNYGRIDPETCRDLFIRHALVEGDWRTHHKFFAANRRLLTEVEELEHRARRRDILVDDETLFDFYDQRVPADVVSGAHFDSWWKKKQREEPELLNFEKSMLINEQAEGVTKDDYPDSWRQGKLKLRVTYQFEPGTDADGVTVHVPLQILNQVVPEGFDWQIPGLREDVVTELIRSLPKPIRRNYVPAPNYAKAFLERAVPVQEPLTTALARELQRMVGVPVAAEDFDWGKVPDHLKVTFRVTDERRRQLAESKDLEELRLKLKPKTQAAITRAFDEAAGAGRGARGAEAESGAGAPALDRRTGLTSWTVGALPRTFETRRQGHTVKAYPALVDEGETVAVRLYDTEAEQAAAMWTGTRRLILLQLPSNPAKFANSTLSNQAKLALSRTPHGGVQALFEDCVTASADRLIAAHGGPAWDEEGFRKLFDSVRADIVDATMQTIRQVQEVLAAWHACEGRLRAVKSPVLAESAADVREQLAWLVKPGFVTEHGAGRLPDLLRYLVAADRRLQQLPTHAERDRARMAKVKEMQDEYAWLLEQQPRGRPVPKAVRDVRWMIEELRVSYFAHALGTAYPVSDKRIVKAVDALVPPTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5R5</accession>
    <name>A0A0F7N5R5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_11645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016114.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_11645"/>
    <dbReference type="EnsemblBacteria" id="AKH82778">
        <property type="protein sequence ID" value="AKH82778"/>
        <property type="gene ID" value="AA958_11645"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_11645"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2449"/>
    <dbReference type="OrthoDB" id="1540164at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000281">
        <property type="entry name" value="HTH_RpiR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01418">
        <property type="entry name" value="HTH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51071">
        <property type="entry name" value="HTH_RPIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH rpiR-type" evidence="1">
        <location>
            <begin position="6"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="278" mass="29499" checksum="D1770715DCB60E87" modified="2015-07-22" version="1">MVSADAGARLQKLFEGRRLTPTQRRIAHCMVRRAADAPFLSSVELAELAGVSQPSVTRFAVALGFDGYPALRRALREAGLGEPSGRTERNEYQQAVQAEIENLRNLAALLADPAPVEDAGRLLAASRPLPVLGLRAAAAQARGFAYFAAKVHPDIRVLDEAGSMLDDRVDAAARAGATALLCFALPRHPRELSDALRTARATGLTVVTVADSSFTPVAQDSDVLLPAAVGTGLSFDTACGPMLLGRVLLEAMCDALPEAQARLEEFDARAAERGLFLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5R7</accession>
    <name>A0A0F7N5R7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_11710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016124.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH82788">
        <property type="protein sequence ID" value="AKH82788"/>
        <property type="gene ID" value="AA958_11710"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_11710"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2462"/>
    <dbReference type="OrthoDB" id="1789270at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007374">
        <property type="entry name" value="ASCH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04266">
        <property type="entry name" value="ASCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01022">
        <property type="entry name" value="ASCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ASCH" evidence="1">
        <location>
            <begin position="11"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="125" mass="13705" checksum="E509E15A1A2051BE" modified="2015-07-22" version="1">MTGITARVHELDLYRQYFDLVAAGRKSVEVRVKYPHLADLAAGDVIRFRIKGTAETVDVRVTRVNEYPTFEALLDGEGPENVNPTAPRAQQLANIRSIYGPEKEALGALALSITRVMAGQRPPSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5V2</accession>
    <name>A0A0F7N5V2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GDSL family lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_11650</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016115.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_11650"/>
    <dbReference type="EnsemblBacteria" id="AKH82779">
        <property type="protein sequence ID" value="AKH82779"/>
        <property type="gene ID" value="AA958_11650"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_11650"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2450"/>
    <dbReference type="OrthoDB" id="1247435at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH_hydro" evidence="3">
        <location>
            <begin position="76"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH82779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="344" mass="35938" checksum="77C71F141416E6C8" modified="2015-07-22" version="1">MSMTRARAARRIAAAAAYGGGGIGLLGGATLGVLVAEVHLARRRVGGSDEEPPRADGRYGASFGRRRGVRPVLLAFLGDSTAAGQGVYRPRQTPGALLASGLAAVAERPVDLRNVALSGAQSDDLDRQVTLLLDEEGLRPDVAVIMVGANDVTHRVPPAVSVRCLSDAVARLRDAGTEVVVGTCPDLGTIEPVQQPLRWLARRLSRQLAAAQTIAVLDRGGRTVSLGTLLGPEFAANPRELFGPDNYHPSAEGYATAAMALLPTLSAALGLWPAEEERPDVRRDEGYLPVAKAAAQAAGESGTEVAPAGPAGGRGPWALLKHRRRRRVAESETDAEQTAVGERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5W3</accession>
    <name>A0A0F7N5W3_9ACTN</name>
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        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_19235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_19235"/>
    <dbReference type="EnsemblBacteria" id="AKH83965">
        <property type="protein sequence ID" value="AKH83965"/>
        <property type="gene ID" value="AA958_19235"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_19235"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4045"/>
    <dbReference type="OrthoDB" id="922937at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041413">
        <property type="entry name" value="MLTR_LBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17765">
        <property type="entry name" value="MLTR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="33"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="270" mass="30056" checksum="8F21353A94273E0C" modified="2015-07-22" version="1">MSDDSRVSQPGLGELLKEWRKRTQYRLGRSRPLSQMAVAARVGIATRTYQGLELGEPRRRLSPDTADALARVFDLEADERDLLFLLGARVRPGPAHAAGPDAAVLADLRLVLDSADPTPAILLDAMGNVHMHNHAMSTWIPYVREPHANLVRWCLSHPDARTQIVDWSQYVRMWFAILRNYQAVYGSDGLGVQEILAIIDADPVLKPIWEESRDVRQDLGGERSALRLPCYGGKRVEVILHVLHPTAAPHYRVGVLTPITPVPAMEESSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N614</accession>
    <name>A0A0F7N614_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Lantibiotic protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_19630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018840305.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_19630"/>
    <dbReference type="EnsemblBacteria" id="AKH84020">
        <property type="protein sequence ID" value="AKH84020"/>
        <property type="gene ID" value="AA958_19630"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_19630"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4136"/>
    <dbReference type="OrthoDB" id="2095147at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023895">
        <property type="entry name" value="Thiopep_bacteriocin_prcur"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03892">
        <property type="entry name" value="thiopep_precurs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH84020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="57" mass="5863" checksum="7FB5E5793C8914F0" modified="2015-07-22" version="1">MADKALSTLADEILELESETFEISDYSDQAEVVLAGSTSCSSTSTCSSTTSTTSCSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6E8</accession>
    <name>A0A0F7N6E8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SBP_bac_5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_17050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016940.1">
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_17050"/>
    <dbReference type="EnsemblBacteria" id="AKH83636">
        <property type="protein sequence ID" value="AKH83636"/>
        <property type="gene ID" value="AA958_17050"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_17050"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3585"/>
    <dbReference type="OrthoDB" id="162819at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519251" description="SBP_bac_5 domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="2">
        <location>
            <begin position="91"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH83636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="529" mass="58623" checksum="6E3DAE6B8068E9A8" modified="2015-07-22" version="1">MAPFSRRHLLAAGGGALGSAVLAACGSPVNLPSSMEEVTPRPGGPSRGGVLHFGLSTDPANLDPHVTTGAASDLLRQLTYNALLQYDGDGEIIGDLAAEFGWADDTTYEVKLRPGVRFHDGSRLTTKDVAFSFRRMRDEKTAATTGPLLDLIEEVEAKDDTTVLFHLRQADSTIPFVLANPTANIVSQRWIESGVDPKTQVMGTGPFRFVERIPGVSTTYERFDEYFEPELPYLNAMVFQPMSDDYARVTALRTATVDMIDYVPATHVDVISENPRLRFASDRSFGFGFVGFVTSKPPFDDVRVRRAVAMAINRDSVLETALLGHGQPIDGALMPPAFARYSGSLDNTMDYDPEQARFLLKQAGQENLTLPTVTTSTYSVIARPAQAMLPGIRAAGVDVRLTQQEWLTFRASVEAKSYPVHSWGTAPKFGDPASLSDFLGSTGTFTKNTDFKDERLDQLLAEGRRTRDRALRDEIYRDVEQRALELVPMTWTVRRQQGEAHYDYVKGYRHPPKGSWTGVTLRRIWMDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6I3</accession>
    <name>A0A0F7N6I3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Addiction module toxin RelE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_17365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016990.1">
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_17365"/>
    <dbReference type="EnsemblBacteria" id="AKH83686">
        <property type="protein sequence ID" value="AKH83686"/>
        <property type="gene ID" value="AA958_17365"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_17365"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3652"/>
    <dbReference type="OrthoDB" id="2036672at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007712">
        <property type="entry name" value="RelE/ParE_toxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035093">
        <property type="entry name" value="RelE/ParE_toxin_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05016">
        <property type="entry name" value="ParE_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143011">
        <property type="entry name" value="SSF143011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="95" mass="10757" checksum="9C7C157BCFF1BC02" modified="2015-07-22" version="1">MTDGVSSTKLTQAAQRQMRAVPLREARRILIRLGEFQRAMDKGDTSAFDIKPQTGQEGMSRLRVGDYRVVYTVDNGELVIWVVAVGDRRDVYRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6R4</accession>
    <name>A0A0F7N6R4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_13270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016370.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_13270"/>
    <dbReference type="EnsemblBacteria" id="AKH83039">
        <property type="protein sequence ID" value="AKH83039"/>
        <property type="gene ID" value="AA958_13270"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_13270"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2792"/>
    <dbReference type="OrthoDB" id="1932679at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519312" evidence="1">
        <location>
            <begin position="37"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="174" mass="18892" checksum="73698AFC26F55DE7" modified="2015-07-22" version="1">MTKAPATTVFSRARGLRSRRGAVALGAVVVSAFALSACEKPTPVAQITVDDRTASAEAQCYDDGKDISNEELESCISERAEKSITVDSGDRVRIGVEPEIADNGWVLFVDGRPVTSQPSKHTYVTYSGDQFFEAQSQPGQPPVQSDKAKVGIVEIDDEGNYKGAWSFDLKRKQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6U2</accession>
    <name>A0A0F7N6U2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GTP cyclohydrolase 1</fullName>
            <ecNumber evidence="5">3.5.4.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">GTP cyclohydrolase I</fullName>
            <shortName evidence="5">GTP-CH-I</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">folE</name>
        <name evidence="8" type="ORF">AA958_18095</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>GTP + H2O = 7,8-dihydroneopterin 3'-triphosphate + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17473"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58462"/>
            <dbReference type="EC" id="3.5.4.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homopolymer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the GTP cyclohydrolase I family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.16" evidence="5"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017101.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_18095"/>
    <dbReference type="EnsemblBacteria" id="AKH83801">
        <property type="protein sequence ID" value="AKH83801"/>
        <property type="gene ID" value="AA958_18095"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_18095"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3805"/>
    <dbReference type="OrthoDB" id="1632367at2"/>
    <dbReference type="UniPathway" id="UPA00848">
        <property type="reaction ID" value="UER00151"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003934">
        <property type="term" value="F:GTP cyclohydrolase I activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035998">
        <property type="term" value="P:7,8-dihydroneopterin 3'-triphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.286.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00223">
        <property type="entry name" value="FolE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043133">
        <property type="entry name" value="GTP-CH-I_C/QueF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043134">
        <property type="entry name" value="GTP-CH-I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001474">
        <property type="entry name" value="GTP_CycHdrlase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018234">
        <property type="entry name" value="GTP_CycHdrlase_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020602">
        <property type="entry name" value="GTP_CycHdrlase_I_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11109">
        <property type="entry name" value="PTHR11109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01227">
        <property type="entry name" value="GTP_cyclohydroI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00063">
        <property type="entry name" value="folE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00859">
        <property type="entry name" value="GTP_CYCLOHYDROL_1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00860">
        <property type="entry name" value="GTP_CYCLOHYDROL_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 5" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="GTP_cyclohydroI" evidence="7">
        <location>
            <begin position="28"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH83801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="207" mass="22913" checksum="427FC6FDC5CBD144" modified="2015-07-22" version="1">MTDAAVRTGHGPEHDDGAYGDFDEKRAEDAVRELLIAVGEDPDREGLLDTPARVARAYKEIFAGLRQRPEDVLTTTFDLGHDEMVLVKDIEVLSTCEHHLVPFVGSAHVGYIPSHDGKITGLSKLARLVDVYARRPQVQERLTTQIADSLMEILEPRGVIVVIECEHLCMTMRGVRKPGAKTLTSAVRGQLRHPATRAEAMSLIRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6X1</accession>
    <name>A0A0F7N6X1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AA958_13790</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016457.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_13790"/>
    <dbReference type="EnsemblBacteria" id="AKH83128">
        <property type="protein sequence ID" value="AKH83128"/>
        <property type="gene ID" value="AA958_13790"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_13790"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2904"/>
    <dbReference type="OrthoDB" id="1425894at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010619">
        <property type="entry name" value="ThrE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024528">
        <property type="entry name" value="ThrE_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06738">
        <property type="entry name" value="ThrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12821">
        <property type="entry name" value="ThrE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="244"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="293"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="358"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="396"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="420"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="445"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="471"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="504"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="ThrE" evidence="7">
        <location>
            <begin position="132"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="ThrE_2" evidence="8">
        <location>
            <begin position="399"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="74"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH83128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="552" mass="57715" checksum="49177260F9725757" modified="2015-07-22" version="1">MGQEPEPDNGEEKPQSDEAHSAFTPPFGVPLPPPPEDGQTTSEFALPAGVGEHAAEDHGNGHSGFRPPRGGPAAAAGVAPPPPPATGPLSRSTPWQDRMRVMLRTPMTERPTPERTLSPTEETALPVPRVLDLTLRIGELLLAGGEGAEDVEAAMFAIAHAFGLDRCEPTVTFTLLTVTYQPSLVDDPVTLSRTVRRRGTDYNRLSAVYRLVDAIVDEEAAVSLEEAYRGLAEIRRNRHPYSKWALTVASGGLSGAAATLVGGGPLVFCAAAIGAMLGDRLAWLAAGRGLPEFYQFVAAAMAPAAVGVTLNIAAVEAQSSAVITGGLFALIPGRALVAAVQDGLTGYYITASARLLEVLYLVVGIVVGVLIVLYVGVQLGAELSPDAALHRQERPIVSLLAAMLLTLAFAVLLQQERSTVIVVTLNGGVAWLIYAVIAHQANKSAVLATALAAGLVGLFGQLLSRYRFISALPYVTAAIGPLLPGSATYFGLLGFAQDNLNAGARSLLTAAALALAIAIGVNLGGEMARLFMKRPGEKTAPARRGVKRTRGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7C3</accession>
    <name>A0A0F7N7C3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Beta-ketoacyl synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_14840</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016599.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_14840"/>
    <dbReference type="EnsemblBacteria" id="AKH83284">
        <property type="protein sequence ID" value="AKH83284"/>
        <property type="gene ID" value="AA958_14840"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_14840"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3128"/>
    <dbReference type="OrthoDB" id="606297at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
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    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000794">
        <property type="entry name" value="Beta-ketoacyl_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712">
        <property type="entry name" value="PTHR11712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_KS" evidence="4">
        <location>
            <begin position="29"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH83284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="439" mass="44767" checksum="2809C59BD5396BFA" modified="2015-07-22" version="1">MTATAGAATTAAGQTTTRETSTAPTSALVTGIGIVAPNGTGTDDYWTATLTSTSGIGPIQRFDTRPYPVHIGGEVTHFDADALLPQRILPQTDRMTRYALAAADWALADAGLTPGNPGPSDPGAAGLGEYDLGVLTAGACGGFEFGQRELQKLWGTGPERVSTYQSFAWFYAVNTGQISIRHGLRGHSSVFVSEQAGALDAAAQTARLLRTGTLGAALTGGFDAPLCPWGLAVQLPTGLLSTATEPERAYLPFDTDAAGYAVGEGGALLVVEREDTALRRNAAGIYGRIAGHASTFDPRPGSGRPPALAAAITGALDEARLDPADVDVVFADALGVPAADRAEAEALVRVFGPSAVPVTAPKTLTGRLYAGGAALDVATALLSIRDSVIPPTAGTRSPAPGLGIDLVLDGPRETAVRHALVVARGAGGFNSALVLSRYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7E5</accession>
    <name>A0A0F7N7E5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ArsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_14995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016624.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_14995"/>
    <dbReference type="EnsemblBacteria" id="AKH83309">
        <property type="protein sequence ID" value="AKH83309"/>
        <property type="gene ID" value="AA958_14995"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_14995"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3160"/>
    <dbReference type="OrthoDB" id="1617768at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="114" mass="12244" checksum="30B7F0077887D7FE" modified="2015-07-22" version="1">MTAAAGPAVVCAALGEPTRWTILTRLGEGPMSASALAKVMPVSRQAIGKHLDVLREVGLVESEQRGREVVYVAVGARLHALARELDRVGRAWESRLLRIKELAELPDSGPPPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7F1</accession>
    <name>A0A0F7N7F1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MerR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_19125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017246.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH83951">
        <property type="protein sequence ID" value="AKH83951"/>
        <property type="gene ID" value="AA958_19125"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_19125"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4021"/>
    <dbReference type="OrthoDB" id="1748559at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="127" mass="14305" checksum="C16E98F166115AE1" modified="2015-07-22" version="1">MTVGELSRRTGVPIKSLRAYTDLGLICSQGRSPANYRLYDDHALWCVHRIGTLRGLGLTVAEIRDLTTASREDDNVTASPASPRFTQFLARSRARLEQRIAAQQRMLRRIEEYQAAHQEETAACDIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7L8</accession>
    <name>A0A0F7N7L8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Mobile element transfer</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_15365</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016672.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_15365"/>
    <dbReference type="EnsemblBacteria" id="AKH83359">
        <property type="protein sequence ID" value="AKH83359"/>
        <property type="gene ID" value="AA958_15365"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_15365"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3232"/>
    <dbReference type="OrthoDB" id="1973243at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007806">
        <property type="entry name" value="SpdB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05122">
        <property type="entry name" value="SpdB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH83359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="63" mass="7005" checksum="8C8760CDB72FE134" modified="2015-07-22" version="1">MPLNRRFRRVIRIGPVQVGTAPDERGRDKHTAACTAPRCGFSADYNSRAAAELAARTHRCPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7T0</accession>
    <name>A0A0F7N7T0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_16160</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the thioredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016796.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_16160"/>
    <dbReference type="EnsemblBacteria" id="AKH83488">
        <property type="protein sequence ID" value="AKH83488"/>
        <property type="gene ID" value="AA958_16160"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_16160"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3405"/>
    <dbReference type="OrthoDB" id="1630944at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000077">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01068">
        <property type="entry name" value="thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 4" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="5">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="4">
        <location>
            <begin position="33"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000077-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH83488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="109" mass="11681" checksum="6C898A9E5EB41986" modified="2015-07-22" version="1">MAGATVTATDADFEEKVLKSDKPVLVDFWAAWCGPCRQIAPSLEAIAAENPEKITIVKLNIDENPATAAKYGIMSIPTMNVYQGGEVVKTIVGAKPKTALERDLSEFIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7Y6</accession>
    <name>A0A0F7N7Y6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_23655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017960.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_23655"/>
    <dbReference type="EnsemblBacteria" id="AKH84705">
        <property type="protein sequence ID" value="AKH84705"/>
        <property type="gene ID" value="AA958_23655"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_23655"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4986"/>
    <dbReference type="OrthoDB" id="2037786at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007423">
        <property type="entry name" value="Sel_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04328">
        <property type="entry name" value="Sel_put"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="67" mass="7743" checksum="07A704BA8B92D23C" modified="2015-07-22" version="1">MTGTAALAAAGRKVWWYVREVIGDTAYERYVEHLRGHDPDAKVPTRREFERMRTDAGDDPRKGFRCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8H3</accession>
    <name>A0A0F7N8H3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tryptophan 2,3-dioxygenase</fullName>
            <shortName evidence="1">TDO</shortName>
            <ecNumber evidence="1">1.13.11.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Tryptamin 2,3-dioxygenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Tryptophan oxygenase</fullName>
            <shortName evidence="1">TO</shortName>
            <shortName evidence="1">TRPO</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Tryptophan pyrrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Tryptophanase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">kynA</name>
        <name evidence="3" type="ORF">AA958_17655</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-tryptophan + O2 = N-formyl-L-kynurenine</text>
            <dbReference type="Rhea" id="RHEA:24536"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58629"/>
            <dbReference type="EC" id="1.13.11.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
        <text evidence="1">Binds 1 heme group per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the tryptophan 2,3-dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.11" evidence="1"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017033.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_17655"/>
    <dbReference type="EnsemblBacteria" id="AKH83729">
        <property type="protein sequence ID" value="AKH83729"/>
        <property type="gene ID" value="AA958_17655"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_17655"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3718"/>
    <dbReference type="OrthoDB" id="1660023at2"/>
    <dbReference type="UniPathway" id="UPA00333">
        <property type="reaction ID" value="UER00453"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004833">
        <property type="term" value="F:tryptophan 2,3-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01972">
        <property type="entry name" value="T23O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037217">
        <property type="entry name" value="Trp/Indoleamine_2_3_dOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004981">
        <property type="entry name" value="Trp_2_3_dOase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10138">
        <property type="entry name" value="PTHR10138"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03301">
        <property type="entry name" value="Trp_dioxygenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140959">
        <property type="entry name" value="SSF140959"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0823">Tryptophan catabolism</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="1">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH83729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="296" mass="33364" checksum="E597EF377A6BCF13" modified="2015-07-22" version="1">MDSRAHDPLPAETDGRQTPEDRQTPDGHQPPNLDFRGTTPYEDYVQADVLTHLQHPLSDDPGELVFLVTTQVMELWFTVIVHEWETAAEALRRDDLPVALAALRRSTYELRSLNASWEPLARLTPRQFNSYRAALGEGSGFQSAMYRRMEFLLGEKSASMLVPHRGAPRVHDELEKQLGEPSLYDEVLRYLDAKGHRLSADVLDRDPARRYEPHPEVEAAWAAVYAGPQDSGLIQLGEVLTDIAELVWRWRNDHLVATRRAMGGKVGTGGSAGVSWLEKRAAKQVFPELWTARSHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8I8</accession>
    <name>A0A0F7N8I8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_24500</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018097.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_24500"/>
    <dbReference type="EnsemblBacteria" id="AKH84845">
        <property type="protein sequence ID" value="AKH84845"/>
        <property type="gene ID" value="AA958_24500"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_24500"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5162"/>
    <dbReference type="OrthoDB" id="2047542at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039538">
        <property type="entry name" value="BetI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13977">
        <property type="entry name" value="TetR_C_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="10"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="2">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH84845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="204" mass="22748" checksum="6D871EB2FFE901B3" modified="2015-07-22" version="1">MARVSQAHLDARRRQILDGARRCFTRNGFHATSMQDVFQETGLSSGAVYRYFRGKNDLITAVAEEAFERMRLAFESASHEAPLRPLADVIDGVLTHVLEEQARTSGVDRPGAFAELIVQVWSETLRDEGLAATLNAGYDRMRAMWGKVVRTYQEAGHLRADVPTDHLVRALMALVQGFILQQAVFKDVEAELRSGLRALLSPHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8U9</accession>
    <name>A0A0F7N8U9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_18985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017228.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_18985"/>
    <dbReference type="EnsemblBacteria" id="AKH83933">
        <property type="protein sequence ID" value="AKH83933"/>
        <property type="gene ID" value="AA958_18985"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_18985"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3985"/>
    <dbReference type="OrthoDB" id="1538566at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="233" mass="24289" checksum="C8AF4D8CFB35640B" modified="2015-07-22" version="1">MRQKRFPSHALSSPRTGYPGSRRAAIAAAAVAALVALTVAVALLAGGQDVDSGPERAAPALASSPPRAERAPQPAPPSQSGAVPGPPRIGEPVAFAKAAAKMLWSYDTRTTSRTEQLAGMRAWMTTESRYADWASVAGQVPDPLLWSRMADQDQRATASVVEGHLPAAFTQALAEDPTAITEAYVYAVTVTGKQKIAWNKRGGGAEERAVTLAVQCRPGHTCSLAAIAPNVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8X1</accession>
    <name>A0A0F7N8X1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_18480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017161.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH83864">
        <property type="protein sequence ID" value="AKH83864"/>
        <property type="gene ID" value="AA958_18480"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_18480"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3880"/>
    <dbReference type="OrthoDB" id="2085682at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046241">
        <property type="entry name" value="DUF6274"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19790">
        <property type="entry name" value="DUF6274"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="74" mass="7684" checksum="DA0318E7757F0F36" modified="2015-07-22" version="1">MTTTVRHETKALLRAHLSAASSYGHLTPHCAVCSRLLRLAMESGQPPEIADANDGARASDAAETAARDGATLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N971</accession>
    <name>A0A0F7N971_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Integrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_19320</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017274.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_19320"/>
    <dbReference type="EnsemblBacteria" id="AKH83979">
        <property type="protein sequence ID" value="AKH83979"/>
        <property type="gene ID" value="AA958_19320"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_19320"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4062"/>
    <dbReference type="OrthoDB" id="745068at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="5">
        <location>
            <begin position="71"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="4">
        <location>
            <begin position="148"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH83979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="366" mass="41601" checksum="5BF385949E9AE384" modified="2015-07-22" version="1">MRRPGVELAGSAKLELVSGVVQLHPEDAVWEAMLRGWQSQQQARNLKPGTVDPRVQLVRGFQGFINEYPWNWTPAHMDEWSAALTTEKHLAPSTVRGYQGTLRLFSEYLIDPRYGWAALCEAEFGSHPVAICHEWNTIPHLQDYEGGPEARPFTREELQRFLDYADDQVERAIRSGRKGALAAYRDATLFKVVYGWGLRRTETSKLDLVDFGRNPKAPRFGRYGTLNVRYGKAKNGQPPRRRNVLSVMDWAVEAVDDYVGNVWPRFGFPDLPALWITERGGRLRPGSINDRFEEYRDALGLPKELSPHSLRHSYVTHLTEDGVDRFFIQKQVGHECDSSLAVYTHVSDDFMNTSLQNALAPAFAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9T6</accession>
    <name>A0A0F7N9T6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5 7">30S ribosomal protein S12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpsL</name>
        <name evidence="9" type="ORF">AA958_21070</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 7">Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="1 5 7">With S4 and S5 plays an important role in translational accuracy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 5 7">Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5 6">Belongs to the universal ribosomal protein uS12 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003948652.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A0F7N9T6"/>
    <dbReference type="STRING" id="444103.AA958_21070"/>
    <dbReference type="EnsemblBacteria" id="AKH84268">
        <property type="protein sequence ID" value="AKH84268"/>
        <property type="gene ID" value="AA958_21070"/>
    </dbReference>
    <dbReference type="GeneID" id="58470329"/>
    <dbReference type="GeneID" id="63982115"/>
    <dbReference type="GeneID" id="67401280"/>
    <dbReference type="KEGG" id="strc:AA958_21070"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4437"/>
    <dbReference type="OrthoDB" id="1707228at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03368">
        <property type="entry name" value="Ribosomal_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00403_B">
        <property type="entry name" value="Ribosomal_S12_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006032">
        <property type="entry name" value="Ribosomal_S12/S23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005679">
        <property type="entry name" value="Ribosomal_S12_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11652">
        <property type="entry name" value="PTHR11652"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00164">
        <property type="entry name" value="Ribosom_S12_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002133">
        <property type="entry name" value="Ribosomal_S12/S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01034">
        <property type="entry name" value="RIBOSOMALS12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00981">
        <property type="entry name" value="rpsL_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00055">
        <property type="entry name" value="RIBOSOMAL_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 6 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0820">tRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH84268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="123" mass="13771" checksum="9F9C1621AD40D5A0" modified="2015-07-22" version="1">MPTIQQLVRKGRQDKVEKNKTPALEGSPQRRGVCTRVFTTTPKKPNSALRKVARVRLTSGIEVTAYIPGEGHNLQEHSIVLVRGGRVKDLPGVRYKIIRGSLDTQGVKNRKQARSRYGAKKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9U1</accession>
    <name>A0A0F7N9U1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine/threonine protein phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_15930</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_15930"/>
    <dbReference type="EnsemblBacteria" id="AKH83452">
        <property type="protein sequence ID" value="AKH83452"/>
        <property type="gene ID" value="AA958_15930"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_15930"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3356"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="2">
        <location>
            <begin position="62"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH83452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="334" mass="35749" checksum="DD1028800FC5C977" modified="2015-07-22" version="1">MQQGAGQTPGLRTTAGVPAGAAPPVPAAPAAGDAFGHADDGYTPTQADLPVIRRGESGGYGPLYVVGDVHGYLDELRAALRAQGIVDEADRWIAGNTRVWFLGDFTDRGPDGIGVIDLVMRLSAEAAAAGGYCKALMGNHELLLLGAKRFGDTPVNSGAGTASFQAAWLLNGGQRTDMERLEDVHLQWMARLDAIHEEDDHLLVHSDTTAYLDYGDSIEGVNDTIHDILARSEADEVWDLFRKFTKRFAFRDEETGPSAVRELLGRYGGERLVHGHSPIPYLLGEVPSEDTDPEERGASVQGPHIYADDLAIAMDGGVTMAGKLLVVRLPLVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAK5</accession>
    <name>A0A0F7NAK5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Orotate phosphoribosyltransferase</fullName>
            <shortName evidence="4">OPRT</shortName>
            <shortName evidence="4">OPRTase</shortName>
            <ecNumber evidence="2 4">2.4.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">pyrE</name>
        <name evidence="6" type="ORF">AA958_17675</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>diphosphate + orotidine 5'-phosphate = 5-phospho-alpha-D-ribose 1-diphosphate + orotate</text>
            <dbReference type="Rhea" id="RHEA:10380"/>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57538"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 4">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.10" evidence="2 4"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017035.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_17675"/>
    <dbReference type="EnsemblBacteria" id="AKH83732">
        <property type="protein sequence ID" value="AKH83732"/>
        <property type="gene ID" value="AA958_17675"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_17675"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3722"/>
    <dbReference type="OrthoDB" id="1280396at2"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00119"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004588">
        <property type="term" value="F:orotate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01208">
        <property type="entry name" value="PyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023031">
        <property type="entry name" value="OPRT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004467">
        <property type="entry name" value="Or_phspho_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00336">
        <property type="entry name" value="pyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 4" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="5">
        <location>
            <begin position="112"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="5-phosphoribose 1-diphosphate binding" evidence="4">
        <location>
            <begin position="125"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>orotate</name>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>orotate</name>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH83732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="185" mass="19205" checksum="A83CD836532AB472" modified="2015-07-22" version="1">MSDAHADLLGQIKDKAVVHGKVTLSSGIEADYYLDLRRITLDGSAAPLVGRVMLDLAKDFAYDAVGGLTLGADPIADAMLHASAAAGDRARPLDAFVVRKASKTHGMQRRIEGPDVAGRRVLVVEDTSTTGGSALTAVEAVREAGAEVVAVATIVDRDTGAAERVRDTAGVPYLYAYGLSDLGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAN0</accession>
    <name>A0A0F7NAN0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_22530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017773.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH84514">
        <property type="protein sequence ID" value="AKH84514"/>
        <property type="gene ID" value="AA958_22530"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_22530"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4741"/>
    <dbReference type="OrthoDB" id="2073172at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="68" mass="7441" checksum="70829DFB143380D5" modified="2015-07-22" version="1">MWKPNDVLLRSLAATQRLHHGRKRDRGQTAVEYLGIIAVAVVIVLVLIQSGLGELILGKIQDQIGKIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAR4</accession>
    <name>A0A0F7NAR4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase P60</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_18010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_18010"/>
    <dbReference type="EnsemblBacteria" id="AKH83787">
        <property type="protein sequence ID" value="AKH83787"/>
        <property type="gene ID" value="AA958_18010"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_18010"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3788"/>
    <dbReference type="OrthoDB" id="1891666at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008258">
        <property type="entry name" value="Transglycosylase_SLT_dom_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01464">
        <property type="entry name" value="SLT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NlpC/P60" evidence="2">
        <location>
            <begin position="193"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH83787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="328" mass="34928" checksum="886E6299AD3FF8F9" modified="2015-07-22" version="1">MRKLWLFVALGSGMVLSFLALLVVGTYTAASGLAGRGVGLAKGAVPATYQSLVQEWGNLCPALNPALLAAQLYQESGWDPNAVSPADARGIAQFMPGTWATHGIDANGDGERDINDPEDAIPSAATYDCKLAGYVEDVPGDQTENMLAAYNAGPYAVIKYNGVPPYRETQNYVQIIQALEESFAAPTSRLSPSKQAAGAIHYAQDKLGTPYLWGGDGTPEEGGRFDCSGLTKAAYASVDIELPRVANDQWNAGPHPSRDELLPGDLVFFAYDMNDSRSIHHVGLYVGGGYMIDAPYTGAVIRFDPIDSPDYFGATRVTEAGAEALPKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAU8</accession>
    <name>A0A0F7NAU8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_29145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_29145"/>
    <dbReference type="EnsemblBacteria" id="AKH85635">
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        <property type="gene ID" value="AA958_29145"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_29145"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6142"/>
    <dbReference type="OrthoDB" id="2040681at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="1">
        <location>
            <begin position="5"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Usp" evidence="1">
        <location>
            <begin position="139"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="271" mass="28046" checksum="8F0A16EEAF5290AF" modified="2015-07-22" version="1">MSGCVVAVIDGSESSAAAVDWAAGEAVTLGAELRLVHVAAAKPEPPADTPAPGIGLLLERAARHLAGRHPALQVTTRLRHGDPGVEPAPAGAEAEAGLLVLGAPGPESSGGVVSALVARASCAVALVPAGEREPDSGEVVLGIDAHHADQPAVDLAFATAQRRGAVLRAVHAWGLPPAAERLSYAVPEEDRGEWEDQEVQRLSDTLRGWRERYPAVHVHDDLRLLPPDEALVAASARAERIVVGRGGTRLSPTTEAVLQRARCPVVVVPAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NB33</accession>
    <name>A0A0F7NB33_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_23380</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017914.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_23380"/>
    <dbReference type="EnsemblBacteria" id="AKH84659">
        <property type="protein sequence ID" value="AKH84659"/>
        <property type="gene ID" value="AA958_23380"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_23380"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4929"/>
    <dbReference type="OrthoDB" id="1437290at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045823">
        <property type="entry name" value="TetR_C_32"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19344">
        <property type="entry name" value="TetR_C_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="19"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH84659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="213" mass="23248" checksum="89FE1F36FBC66E61" modified="2015-07-22" version="1">MTAMEQAETRPRSTRLPRRARRNQLLGAAQEVFVAQGYHSAAMDDIADRAGVSKPVLYQHFPGKLELYLALLDQHCDALLQAVRAALASTSDNKQRVAATMDAYYAFVEDEGGAFRLVFESDLTNEPAVRERVDRVSLDCAQAVSEVIAEDTDLPVEQAMLLAVGLCGMAQITARYWLGAGRSIPRDDAARLIASLSWRGIAGFPMHGGPEQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NB39</accession>
    <name>A0A0F7NB39_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">RNA helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AA958_18690</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017189.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_18690"/>
    <dbReference type="EnsemblBacteria" id="AKH83892">
        <property type="protein sequence ID" value="AKH83892"/>
        <property type="gene ID" value="AA958_18690"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_18690"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3920"/>
    <dbReference type="OrthoDB" id="643629at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Q_MOTIF" evidence="9">
        <location>
            <begin position="58"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="89"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="288"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="488"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="5">
        <location>
            <begin position="58"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="522"/>
            <end position="714"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AKH83892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="714" mass="78253" checksum="7DE855E4B9A35259" modified="2015-07-22" version="1">MLAPALDEAETPEVTEITEAPETAAADGTGDTTVTGETGDSTDTGGTVTGDAPEAAAPTFGDLGLPRGVVAKLADYGVTTPFPIQAATIPDALAGRDVLGRGRTGSGKTLSFGLPLLATLAGGHTDPKRPRGLILTPTRELAMQVADALQPYGDVLRLSMKVVCGGTSMGRQIGALERGVDVLVATPGRLRDVIDRGACSLDRVQIAVLDEADQMADLGFLPEVTELLDQVRPGGQRMLFSATLDKGVGTLVERYLVDPVSHEVDPSAGAVTTMTHHVFVVKPRDKAPVTAAIAARKGRTIVFVRTQLGADRVADQLRETGVRAAALHGGMTQGARTHTLADFKDGRVHALVATDVAARGIHVDGIDLVLNVDPAGDHKDYLHRAGRTARAGESGTVVSLALPHQRRTVFRLLEDAAVDASRHIISGRGAFDPDVARITGARSIDEVQAESAAQAATAAERDVTQLEAQLERARKHAADLRAEATRLATRAGVTPEQPAPEASTAEQAGADAGAETAPAEPRSEARSYDARADRGYDRTDRNGTRQDRREQRFREFDRSADSRRTDREYPRRDNRDGRETRDYRNDRRDDRSYDRRDDRPSYDRRDDRSYGTREPRSYDRRDTRRDDRGTRPYDRGTRSYPRRDDRGAARPYDRDNRRPYERRDSADRSRFGGDRPAGRDRRDGRPYSHDSRTTDDRRTDKPRWKRQDRNNRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBJ5</accession>
    <name>A0A0F7NBJ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_19910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017362.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH84072">
        <property type="protein sequence ID" value="AKH84072"/>
        <property type="gene ID" value="AA958_19910"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_19910"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4195"/>
    <dbReference type="OrthoDB" id="1704351at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="216" mass="22989" checksum="F9DCCCE698B0D265" modified="2015-07-22" version="1">MKARSAGASAVAAALGAVLLLAGCGGDDGGPSSGDRIEGAKTGNKEPSGDPSEKEPGAPEFDLPDDVKVEIAEDATGDEEKDAILRDHGYALMAQQEAYAATEATPNFEQYWDGEAAATFEADFAAYRKDGITITGLDTFYFREVTSLKGDRAVVAYCEDQSEAYVKDAETGKVDKTPADLDSYIDARATMEKSGDIWKVVDYQATRGSKECRDEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBJ8</accession>
    <name>A0A0F7NBJ8_9ACTN</name>
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        <submittedName>
            <fullName evidence="2">5,10-methylene tetrahydromethanopterin reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_28565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018775.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_28565"/>
    <dbReference type="EnsemblBacteria" id="AKH85541">
        <property type="protein sequence ID" value="AKH85541"/>
        <property type="gene ID" value="AA958_28565"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_28565"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6018"/>
    <dbReference type="OrthoDB" id="1434838at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022315">
        <property type="entry name" value="F420_OxRdatse_CPS4043_pred"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03842">
        <property type="entry name" value="F420_CPS_4043"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="339" mass="37325" checksum="D59E0965F12E5ACC" modified="2015-07-22" version="1">MDFGLVLQTDPPASAVVGLMRRAENNGFRYGWTFDSTVLWQEPYVIYSRILEHTDRLTVGPMVTNPGTRTWEVTASAFATLNEMYGNRTVCGIGRGDSAMRVAGRPPNTLARLGDAIRVIRDLAEGREAVVDRESGTTLRLPWVENGRLPVWMAAYGPKALALAGQVADGFILQLSDIYLTEFMVKAVRTAAAQAGRDPDDLTICVAAPAYVTDGTPEALAHAREQCRWFGGMVGNHVADLVDRYGEHSDVVPEALTAYVKQRQGYDYSHHGRAGNPSTDFVPDDIVDRFCILGPVEAHLEKLRRLRELGVHQFAIYAMHDAKESTIDAYGKYVIPALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NC30</accession>
    <name>A0A0F7NC30_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA-directed RNA polymerase subunit beta'</fullName>
            <shortName evidence="7">RNAP subunit beta'</shortName>
            <ecNumber evidence="7">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">RNA polymerase subunit beta'</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Transcriptase subunit beta'</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rpoC</name>
        <name evidence="12" type="ORF">AA958_21060</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7 8">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="7">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="7"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017550.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_21060"/>
    <dbReference type="EnsemblBacteria" id="AKH84267">
        <property type="protein sequence ID" value="AKH84267"/>
        <property type="gene ID" value="AA958_21060"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_21060"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4435"/>
    <dbReference type="OrthoDB" id="4421at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01322">
        <property type="entry name" value="RNApol_bact_RpoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045867">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012754">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007083">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376">
        <property type="entry name" value="PTHR19376"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05000">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02386">
        <property type="entry name" value="rpoC_TIGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 7 8" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 7 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RPOLA_N" evidence="11">
        <location>
            <begin position="310"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="385"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="167"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="535"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="537"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="539"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="895"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="971"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="978"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="981"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AKH84267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="1308" mass="145233" checksum="60EA18559B988E98" modified="2015-07-22" version="1">MLDVNFFDELRIGLATADDIRTWSHGEVKKPETINYRTLKPEKDGLFCEKIFGPTRDWECYCGKYKRVRFKGIICERCGVEVTRAKVRRERMGHIELAAPVTHIWYFKGVPSRLGYLLDLAPKDLEKVIYFAAYMITWVDDERRQRDLSSLEAQISVERQQIEQRRDGDLEARAKKQEADLAELEAEGAKADVRRKVREGGEREMKQLRDRAQRELDRLDEVWNRFKNLKVQDLEGDELLYRELRDRFGTYFQGGMGAAALQKRLESFDLDEEAEKLREIIRTGKGQKKTRALKRLKVVSAFQHTRNSPNGMVLDCVPVIPPDLRPMVQLDGGRFATSDLNDLYRRVINRNNRLKRLLDLGAPEIIVNNEKRMLQEAVDALFDNGRRGRPVTGPGNRPLKSLSDMLKGKQGRFRQNLLGKRVDYSARSVIVVGPQLKLHQCGLPKAMALELFKPFVMKRLVDLNHAQNIKSAKRMVERGRTVVYDVLEEVIAEHPVLLNRAPTLHRLGIQAFEPQLVEGKAIQIHPLVCTAFNADFDGDQMAVHLPLSAEAQAEARILMLSSNNILKPADGRPVTMPTQDMVLGLFFLTTDEIEGEKKGEDRSFASVAEAIMAFDAGELSLQANVDIRFPVGSVPPRGWTPPVAEADDGVGGGAAADSDWQPGDPFRLRTTLGRALFNELLPEDYPFIHYTVGKKQLSEIVNDLAERYPKVLVAQTLDNLKSSGFYWATHSGVTIAISDVVVPEAKKEIIAGYEAQDEKVQKQYERGLITKDERTQELIAIWTKATNEVAEAMNENFPKTNPIFMMVNSGARGNMMQMRQIAGMRGLVSNAKNETIPRPIKSSFREGLSVLEYFISTHGARKGLADTALRTADSGYLTRRLVDVSQDVIIREEDCGTDRGLKLEIASVGADGVLRKAEDAETSVYARCLAEDIVVDGKVLAPAGTDLGDVLIDELIRHGVATVKTRSVLTCESAVGTCAMCYGRSLATGKLVDIGEAVGIIAAQSIGEPGTQLTMRTFHTGGVAGEDITQGLPRVVELFEARTPKGVAPISEAAGRVRIEETEKTKKVVVTPDDGSEEVAYGVSKRARLTAGEGDHVEVGQKLTVGTENPHDVLRILGQRAVQVHLVGEVQKVYNSQGVSIHDKHIEIIIRQMLRRVTIIESGDAELLPGELVERSKFEQENRRVVAEGGQPASGRPQLMGITKASLATESWLSAASFQETTRVLTDAAINAKSDSLIGLKENVIIGKLIPAGTGLSRYRNIRVEPTEEAKAAMYSTVGYDDIDYSPFGTGSGQAVPLEDYDYGPYNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NC41</accession>
    <name>A0A0F7NC41_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AA958_31890</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019283.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_31890"/>
    <dbReference type="EnsemblBacteria" id="AKH86055">
        <property type="protein sequence ID" value="AKH86055"/>
        <property type="gene ID" value="AA958_31890"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_31890"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6735"/>
    <dbReference type="OrthoDB" id="692375at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="9">
        <location>
            <begin position="138"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="199"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AKH86055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="433" mass="46579" checksum="CF429DB7B7C41F60" modified="2015-07-22" version="1">MGLSRPHLAVLKRVGALSAQLTPRRVRVRLTLLYGSLFVLSGAVLLAITYLLVARPSGGLVTFKDVQYGSAQSSAQADTRTYRLDEDLGSQESGIVEGMRQQAWHQREAMLDRLLMQSGLALAIMSVIAIGLGWVVAGRVLRPLRTMTSTIRHISARNLHERLVTGGPPDELKDLADTVNGLLGRLETALESQKRFVANAAHELRTPLTLEHALLEETLIDRGATLESFRANFERLLTISKQQATLLESLLTLSSSDRGLESQEPLDLAALTHEVLPAFRPEIGRRELAVRSAVEPARISGDSALIHRLVANLLDNAIDYNVPGGSVEIATGVRDGGAYLSVRNTGAAVPPDQVERLFHPFQRLRRTAGDGHHGLGLSIVRSIATAHGATLTAEARAGGGLAVTVAFPLRDDGPGENVRVAKLAEPGTAPAHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCM2</accession>
    <name>A0A0F7NCM2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_26145</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018369.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_26145"/>
    <dbReference type="EnsemblBacteria" id="AKH85128">
        <property type="protein sequence ID" value="AKH85128"/>
        <property type="gene ID" value="AA958_26145"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_26145"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5504"/>
    <dbReference type="OrthoDB" id="1006830at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032095">
        <property type="entry name" value="Sacchrp_dh-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005097">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16653">
        <property type="entry name" value="Sacchrp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03435">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sacchrp_dh_NADP" evidence="1">
        <location>
            <begin position="3"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Sacchrp_dh_C" evidence="2">
        <location>
            <begin position="151"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH85128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="408" mass="43899" checksum="E7A3786C2B95349E" modified="2015-07-22" version="1">MRILLVGAGGVGTAITRIAARRDFFEAMVVADHDPGRAEAAVAHVRAAHPGPSGARFTAARVDAGDRTAVAALLRTHRCDALLNATDPRFVMPLFEAAYDTAATYVDMAMSLSRPHPVRPYEECGVKLGDEQFAAADRWATSGRLALVGMGVEPGLSDVFARYAADELFDTVEEIGVRDGANLTVDGYDFAPSFSIWTTIEECLNPPVIWDAGRGWHTTEPFSEPEVFDFPAGIGPVECVNVEHEEVLLVPRWIDAQRVTFKYGLGEEFIDVLKTLHKLGLDRTAPVAVGDAKVSPRDVVAACLPDPATLGSRMRGKTCAGTWVRGTKDGGPREVYLHHVADNEETMALDGVQAVVWQTGINPVIALELLATGEWTAAGVLGPEALPPRPFLDLLTSYGSPWSLREGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCS0</accession>
    <name>A0A0F7NCS0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Inositol-1-monophosphatase</fullName>
            <ecNumber evidence="5">3.1.3.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_26930</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>a myo-inositol phosphate + H2O = myo-inositol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:24056"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:84139"/>
            <dbReference type="EC" id="3.1.3.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the inositol monophosphatase superfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.25" evidence="5"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018506.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_26930"/>
    <dbReference type="EnsemblBacteria" id="AKH85269">
        <property type="protein sequence ID" value="AKH85269"/>
        <property type="gene ID" value="AA958_26930"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_26930"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5664"/>
    <dbReference type="OrthoDB" id="1741160at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008934">
        <property type="term" value="F:inositol monophosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052832">
        <property type="term" value="F:inositol monophosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052833">
        <property type="term" value="F:inositol monophosphate 4-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046855">
        <property type="term" value="P:inositol phosphate dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01639">
        <property type="entry name" value="IMPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033942">
        <property type="entry name" value="IMPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020583">
        <property type="entry name" value="Inositol_monoP_metal-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020550">
        <property type="entry name" value="Inositol_monophosphatase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00377">
        <property type="entry name" value="IMPHPHTASES"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00629">
        <property type="entry name" value="IMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00630">
        <property type="entry name" value="IMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH85269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="274" mass="29010" checksum="027E3A87A2920031" modified="2015-07-22" version="1">MTDEPRPEPAAAPQDELLALALEAARRAGELLRDRRPADLGVAATKSSAIDVVTEMDFAAEKLITGFLTEHRPEDGILGEEGASRPGSSGVRWVVDPVDGTVNYLYGRPDWSVSIAAEYAGEAVVGVVAAPMRGETYHAVRGGGAFVNGAPAHCRPAPPMDQALVSTGFNYVLDVRAHQAEVARLLIPRVRDIRRGGSAAIDLCDVACGRLDGYYERGLNPWDLAAGDLIAREGGALTGSRPGGRPDGDLTVAAVPGLFEPLQRLLDELGAWHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCV5</accession>
    <name>A0A0F7NCV5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_31770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86036">
        <property type="protein sequence ID" value="AKH86036"/>
        <property type="gene ID" value="AA958_31770"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_31770"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6708"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH86036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="100" mass="10725" checksum="E0F802377BDFB50A" modified="2015-07-22" version="1">MTADEPAPTVAEMLRANEANWDARVPVHTRSDFYGLDVVTAPAGAGLAVDLLRETDLLPWPRFAAMERDPASGWRRLPATLPAVPLLLALRATPAPVQGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7ND09</accession>
    <name>A0A0F7ND09_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Gluconate 5-dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_33565</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019562.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_33565"/>
    <dbReference type="EnsemblBacteria" id="AKH86340">
        <property type="protein sequence ID" value="AKH86340"/>
        <property type="gene ID" value="AA958_33565"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_33565"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.7088"/>
    <dbReference type="OrthoDB" id="1356861at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH86340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="294" mass="30711" checksum="6C7B939364CAFC30" modified="2015-07-22" version="1">MTGTGERRPGAGDRAAGRFDLTGRTAVVTGAARGLGRAFATGLAEAGADLVLVDLPDAPGLAETAAAVRAHGRRVRTYGQDLARTGELAGLADRIRAAAGPVHILVNNAGTAALERFNEITPESWSHVMRVNADAVFFLSQRLAEHMAADRVPGRIVTVTSKNALVAEAGLAHYNAAKAAAQLLTETLAVELAPHGITANTLAPGMVDTPIDGEFPLEREGFEAAYRERIPLGRYARPEECVGALLLLASDAGAYLTGARIVVDGGVLADQMPRMRFMPPYRSSLPPDDGAGDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDF5</accession>
    <name>A0A0F7NDF5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Putative pre-16S rRNA nuclease</fullName>
            <ecNumber evidence="2">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_03210</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YqgF HJR family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="2"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_03210"/>
    <dbReference type="EnsemblBacteria" id="AKH86525">
        <property type="protein sequence ID" value="AKH86525"/>
        <property type="gene ID" value="AA958_03210"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_03210"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.684"/>
    <dbReference type="OrthoDB" id="2075502at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000967">
        <property type="term" value="P:rRNA 5'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16964">
        <property type="entry name" value="YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00651">
        <property type="entry name" value="Nuclease_YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005227">
        <property type="entry name" value="YqgF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006641">
        <property type="entry name" value="YqgF/RNaseH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037027">
        <property type="entry name" value="YqgF/RNaseH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33317">
        <property type="entry name" value="PTHR33317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03652">
        <property type="entry name" value="RuvX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00732">
        <property type="entry name" value="YqgFc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00250">
        <property type="entry name" value="RNAse_H_YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="YqgFc" evidence="3">
        <location>
            <begin position="4"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH86525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="154" mass="16177" checksum="E8CC7D35C360548A" modified="2015-07-22" version="1">MRRGRRLAVDVGDARIGVASCDPDGILATPVETVPGRDLPAAFRRLAALTEEYEPLEVLVGLPRSLHGGEGPAAAKVRGFAEKLARRVHPVPVRLVDERMSTVTAAQNLRAAGRSSRKGRSVVDQVAAVVILQSALEAERASGVAPGESVEAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDL4</accession>
    <name>A0A0F7NDL4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">5-hydroxyisourate hydrolase</fullName>
            <shortName evidence="6">HIU hydrolase</shortName>
            <shortName evidence="6">HIUHase</shortName>
            <ecNumber evidence="6">3.5.2.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_28420</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>5-hydroxyisourate + H2O = 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23736"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
            <dbReference type="ChEBI" id="CHEBI:58639"/>
            <dbReference type="EC" id="3.5.2.17"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.17" evidence="6"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018748.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_28420"/>
    <dbReference type="EnsemblBacteria" id="AKH85514">
        <property type="protein sequence ID" value="AKH85514"/>
        <property type="gene ID" value="AA958_28420"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_28420"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5989"/>
    <dbReference type="OrthoDB" id="1955791at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033971">
        <property type="term" value="F:hydroxyisourate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014306">
        <property type="entry name" value="Hydroxyisourate_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023418">
        <property type="entry name" value="Thyroxine_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023416">
        <property type="entry name" value="Transthyretin/HIU_hydrolase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036817">
        <property type="entry name" value="Transthyretin/HIU_hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023419">
        <property type="entry name" value="Transthyretin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10395">
        <property type="entry name" value="PTHR10395"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00576">
        <property type="entry name" value="Transthyretin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49472">
        <property type="entry name" value="SSF49472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02962">
        <property type="entry name" value="hdxy_isourate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00768">
        <property type="entry name" value="TRANSTHYRETIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00769">
        <property type="entry name" value="TRANSTHYRETIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TR_THY" evidence="7">
        <location>
            <begin position="8"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH85514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="133" mass="13486" checksum="EBC0773BE433B4AB" modified="2015-07-22" version="1">MSVGAASVSTHILDTSVGRPAAGVAVELSVRTGGTGDGGTGGWTAHAASATDADGRVRDLPALPAGTTHVRLVFATGPYLSEPAAEDRQDAPAHRDGGAFFPEVAVVFAVASGEHYHVPLLLTPFGYSVYRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDV6</accession>
    <name>A0A0F7NDV6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_33990</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the polysaccharide lyase 8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019638.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_33990"/>
    <dbReference type="EnsemblBacteria" id="AKH86416">
        <property type="protein sequence ID" value="AKH86416"/>
        <property type="gene ID" value="AA958_33990"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_33990"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.7178"/>
    <dbReference type="OrthoDB" id="941406at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008929">
        <property type="entry name" value="Chondroitin_lyas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038970">
        <property type="entry name" value="Lyase_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011071">
        <property type="entry name" value="Lyase_8-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012970">
        <property type="entry name" value="Lyase_8_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004103">
        <property type="entry name" value="Lyase_8_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003159">
        <property type="entry name" value="Lyase_8_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38481">
        <property type="entry name" value="PTHR38481"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02278">
        <property type="entry name" value="Lyase_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02884">
        <property type="entry name" value="Lyase_8_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08124">
        <property type="entry name" value="Lyase_8_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48230">
        <property type="entry name" value="SSF48230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49863">
        <property type="entry name" value="SSF49863"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519539" evidence="2">
        <location>
            <begin position="40"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="domain" description="Lyase_8_N" evidence="5">
        <location>
            <begin position="93"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="Lyase_8" evidence="3">
        <location>
            <begin position="376"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="domain" description="Lyase_8_C" evidence="4">
        <location>
            <begin position="629"/>
            <end position="693"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH86416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="729" mass="78439" checksum="1C71C8CBE2B27A07" modified="2015-07-22" version="1">MPENGAAPLLDRRRVLLGGLGLAAGVAGLTLSAPAIARAAEAAGNRAAADDIQLIIERIQQRFLAQGDQIKLANFIYLARTSEALTYAEWLRADGSWPNVDYADTTSSANGRVWSPYHALYRMMAMAHAYRDPDAPGYGKPEIVEALNRALLYWDSVKPTSTNWWEVEIGKSMAMGRVSIFVGDELSAEAREVAYAHNTGRLDPVGANGSWRTENYLYEAVAKRSTADIEQGYDTMAQTIAVDGSGGVKEAVQVDSSFWAHGAQLYSEGYGMALFTIVAAWADVSRGTSFALSDEEVDAIAFYILDGTRWLIRGEIGMMYLGYRPANTIDGVTSYAADFLEPLDRMVRADEGNSAAYRKLADNIRGKTRENGVTGHKYFWRSEFSSHLRAGYGIFTRINSPRMVGSEYRSTFRPEVGNEIDWNAQGATSIQVTNREYDDLVPAFDWFHYPGVTAPYAKVTSTAGKRNAGSFTGGVSDGRYGAVAFTLDRSSTTGRKSYFYFDDEMVALGAGITSTSEHAVHTTVNQGAARGNATVGGKTVRPGTDSAATGASWAYNDEIGYVFPEGGPLRVSNKGQSGSWIDRDPVARNAFTLYFDHGRAPEGAGYAYIVLPGASPAKVRAYAAGPAVRILRNDEQVQAVRHPGLRLTMATFHAAGSLDLGAGRTLRVDQPAVVMLEESGGSAVVSVANPDQPGLTVSVALAAPGRTRRAGFELGSGANLGKTVTQPLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NE06</accession>
    <name>A0A0F7NE06_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GDSL family lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_00975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_00975"/>
    <dbReference type="EnsemblBacteria" id="AKH86471">
        <property type="protein sequence ID" value="AKH86471"/>
        <property type="gene ID" value="AA958_00975"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_00975"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.216"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH_hydro" evidence="1">
        <location>
            <begin position="7"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="237" mass="26480" checksum="2E857425126EA5CD" modified="2015-07-22" version="1">MSDLRPDGSYRGWADLLAARFAAAQPGFRYANLAVRGKLIRQILDEQVDRAAAMEADVITLVGGLNDAIRPRCDMDRVCGVLEEAVAKLAPSCKQLVLMRSPGRDGRVLERVRPRMEQLFAHVDDLAARHGALVVDLYGAGVLRDVRLWDEDRLHLTPEGHRRVGEAVWQTLGGTPAYDWTGPLPPPAPRPPWFTRRTADARFARTHLLPWVRRRLTGRSSGDGRAPKRPELLPYDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NE16</accession>
    <name>A0A0F7NE16_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Salicylaldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_29200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018872.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_29200"/>
    <dbReference type="EnsemblBacteria" id="AKH85643">
        <property type="protein sequence ID" value="AKH85643"/>
        <property type="gene ID" value="AA958_29200"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_29200"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6156"/>
    <dbReference type="OrthoDB" id="384611at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="2">
        <location>
            <begin position="19"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH85643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="486" mass="49704" checksum="80C11F70B09A9C25" modified="2015-07-22" version="1">MAITRELLIDGKDSPAASGRTAEDLNPYTGEVYATVAAAGPEDVARAVAAADAAFPEWAAVSPFARRTLFLRAADLLDTKGDQVAEVMAHEAGGTRPWAYFNVALAANMLREAAAAVTAPRGEVLSAQEEGALGMAVREPMGVVAAFAPWNAPVILGVRAVAAPLAAGNTVVVKPSEDAPIACGLLVADVLREAGLPDGVLNVVTNAPADAAGIAAALISDPRVRAVNFTGSTGVGRIIGTHAATHLKPALLELGGKNSIIVLDDADVGHAVDAASFGVFMNSGQICMSGDRVLVHESLADEFTERFTAKVATLRAGDPRLPDTVVGPLVSEGSARRVAGLVQDAVAKGATVLAGGGEPAGAVYPPTVLTGVTEDAELYHAESFGPVCAVGTFADDDAAVALANDTENGLTCGVITENATHGLAVARRVRTGIVHVGDQSVADEPQAPFGGVGASGYGRFGGRWGIESFSHTRWVTVATQHPRYPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NE53</accession>
    <name>A0A0F7NE53_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_02570</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019735.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_02570"/>
    <dbReference type="EnsemblBacteria" id="AKH86511">
        <property type="protein sequence ID" value="AKH86511"/>
        <property type="gene ID" value="AA958_02570"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_02570"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.550"/>
    <dbReference type="OrthoDB" id="1479518at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519542" evidence="6">
        <location>
            <begin position="28"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="98"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="98"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH86511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="321" mass="33500" checksum="4354421D89820F69" modified="2015-07-22" version="1">MARMAGRRLLYAVPVLLAVTFGVFAIAAASPFDPVKAYAGTAGFSASGEALDQLRDSLGADDPFVTRWWDWLTAVVTGDLGQSTSMRQPVADVIGERIGWTVLLCAVAFAVAIVAGTLLGALAARRRGGLLDRAVTSVAYALEAAPPFWLGLLAVWLFALRLDALPAGGLTDTGTDVVTFGQVAEHVLLPASVLAVSQMPWFVLYVRQGVGDALDEDPVRGARSRGLAERTVLLGHALRSGLLPVLTLIGTRVPELITGALLIETVFSWPGIAAATVEAATSVDFPLLAALTVLATAAVLLGNLLSDLLYGLADPRVGFDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NE74</accession>
    <name>A0A0F7NE74_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutamyl-tRNA(Gln) amidotransferase subunit A</fullName>
            <shortName evidence="5">Glu-ADT subunit A</shortName>
            <ecNumber evidence="5">6.3.5.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">gatA</name>
        <name evidence="7" type="ORF">AA958_25485</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.7"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterotrimer of A, B and C subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the amidase family. GatA subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.7" evidence="5"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018263.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_25485"/>
    <dbReference type="EnsemblBacteria" id="AKH85012">
        <property type="protein sequence ID" value="AKH85012"/>
        <property type="gene ID" value="AA958_25485"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_25485"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5371"/>
    <dbReference type="OrthoDB" id="1239251at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030956">
        <property type="term" value="C:glutamyl-tRNA(Gln) amidotransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00120">
        <property type="entry name" value="GatA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004412">
        <property type="entry name" value="GatA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="PTHR11895"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="SSF75304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00132">
        <property type="entry name" value="gatA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Amidase" evidence="6">
        <location>
            <begin position="28"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="5">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH85012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="500" mass="52392" checksum="C423AA8BA07C9C7B" modified="2015-07-22" version="1">MADSSGIIRQTAAETAAQIAAGDVSAVEVAEAHLARIEAVDEKVHAFLHVDREGALAQARAVDARRERGEQLGPLAGVPLALKDIFTTEGVPTTAGSKMLQGWVPPYDATVTRRLKEAGVVILGKTNMDEFAMGSSTENSAYGHTGNPWDLTRIPGGSGGGSSAAITAYMAALAIGTDTGGSIRQPASVTGTVGVKPTYGGVSRYGMIAFSSSLDQGGPCARTVLDAALLHEVLAGHDPMDSTSIDAPVPAVVEAARHGSVAGTRVGVVKEFRGEGYQPGVMQRFDEAVELLRELGAEVVEVSCPAFDRALAAYYLIAPAEVSSNLARYDGLRYGLRAGDDGTHSAEEVTSLTRAAGFGPEVKRRIMLGTYALSSGYYDAYYGSAQKVRTLITRDFERAYEEVDVLVSPTTPTTAFPIGERVDDPMAMYLADLCTIPSNLAGNAAMSLPCGLAPEDGLPVGLQIIAPAMADDRLYKVGAAVEAAFTDRWGHPLLEEAPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NEQ7</accession>
    <name>A0A0F7NEQ7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">tRNA dimethylallyltransferase</fullName>
            <ecNumber evidence="5">2.5.1.75</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Dimethylallyl diphosphate:tRNA dimethylallyltransferase</fullName>
            <shortName evidence="5">DMAPP:tRNA dimethylallyltransferase</shortName>
            <shortName evidence="5">DMATase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Isopentenyl-diphosphate:tRNA isopentenyltransferase</fullName>
            <shortName evidence="5">IPP transferase</shortName>
            <shortName evidence="5">IPPT</shortName>
            <shortName evidence="5">IPTase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">miaA</name>
        <name evidence="9" type="ORF">AA958_26590</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 5 7">Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5 6">
            <text>adenosine(37) in tRNA + dimethylallyl diphosphate = diphosphate + N(6)-dimethylallyladenosine(37) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:26482"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10375"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74415"/>
            <dbReference type="EC" id="2.5.1.75"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 5 8">Belongs to the IPP transferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.75" evidence="5"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018444.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_26590"/>
    <dbReference type="EnsemblBacteria" id="AKH85207">
        <property type="protein sequence ID" value="AKH85207"/>
        <property type="gene ID" value="AA958_26590"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_26590"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5595"/>
    <dbReference type="OrthoDB" id="1069591at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052381">
        <property type="term" value="F:tRNA dimethylallyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00185">
        <property type="entry name" value="IPP_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039657">
        <property type="entry name" value="Dimethylallyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018022">
        <property type="entry name" value="IPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11088">
        <property type="entry name" value="PTHR11088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00174">
        <property type="entry name" value="miaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 6" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="17"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with substrate tRNA" evidence="5">
        <location>
            <begin position="40"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="15"/>
            <end position="22"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with substrate tRNA" evidence="5">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with substrate tRNA" evidence="5">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH85207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="312" mass="33715" checksum="55D2CF11855E3F54" modified="2015-07-22" version="1">MTETTPRPQVVAVVGATATGKSELGIALARRLGGEIVNADSMQLYRGMNIGTAKLTPAERQGVPHHLLDVWDVTETASVAAYQRLARAEIDRLGALGRTAVLVGGSGLYVRGAVDAMDFPGTDPAVRARLEAELAAAGPAPLHARLAAADPDAAAAILPGNGRRIVRALEVIELTGRPFTANLPAHESVYDTVQIGIAVPRPELADRIERRVHRMWRAGLVDEVRRLEAEGLREGRTAARALGYQQVLAFLAGECTEAEARDETVGATRRFARRQETWFRRDARVHWISGSEADRDRLPDTACDLLERSVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NF11</accession>
    <name>A0A0F7NF11_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_26705</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_26705"/>
    <dbReference type="EnsemblBacteria" id="AKH87050">
        <property type="protein sequence ID" value="AKH87050"/>
        <property type="gene ID" value="AA958_26705"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_26705"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5619"/>
    <dbReference type="OrthoDB" id="1108236at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="241"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="279"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="313"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="343"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="477"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="24"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH87050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="515" mass="53659" checksum="112BD0D9ED9D84D8" modified="2015-07-22" version="1">MTASQLANERGKGKAPRADQRNMALLIIAACQLMVVLDVSVVNIALPHIQNSLDFSTTGLTWVVSAYTLTFGGLLLLGGRAGDILGRRRVLVFGVALFIAASLLGGFAQEPWHLLVARAVQGAGAAIASPTSLALVTTTFPEGPERNRAFGVFAAVSAAGGAIGLLAGGMLTEWLNWRWVLFVNVPIGLLIILTVPLYINESERRPGRFDISGALTSTAGMAALVYGFIRAAEEGWRDSLSIGSFAAAAILLVTFVLVERGAKDPITPLKMFADRNRSGSYVIMLSLAAALFGIFFYLVLFVQNVLEYSPIKAGVAFLPISVAIVASAGLVQKFLPVLGPKPFVIGGSSITAVALAWMVLLDTDSSFLGGVFGPEVVFGFGMGMNFVTLTITSVSGVAQDQAGAASGLLNATQQVGGSLGLSILTTVYGTASRDEAEKQIPAFMDKGSPEQIAGFEKSGELPPPWSKEVLTVGMSQAFVAATAMVVFAVLIAAVAIKVRKADIEALSGMTGPGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NF82</accession>
    <name>A0A0F7NF82_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Proline racemase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_27440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proline racemase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018581.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_27440"/>
    <dbReference type="EnsemblBacteria" id="AKH85347">
        <property type="protein sequence ID" value="AKH85347"/>
        <property type="gene ID" value="AA958_27440"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_27440"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5782"/>
    <dbReference type="OrthoDB" id="559014at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008794">
        <property type="entry name" value="Pro_racemase_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33442">
        <property type="entry name" value="PTHR33442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05544">
        <property type="entry name" value="Pro_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029792">
        <property type="entry name" value="Pro_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00028">
        <property type="entry name" value="Proline_Racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="334" mass="35414" checksum="54408955312B30DE" modified="2015-07-22" version="1">MRASRYFTAVDSHTEGMPTRVITGGVGVVPGATMAERRAYFAEHLDDIRQLLVNEPRGHAAMSGAILQPPTRPDADYGVLYIEVSGLLPMCGHGTIGVASVLVETGMVTVTEPVTEVRLDTPAGLVTARVTVSGGKAESVSFRNVPSFALELDAAVEVPGLGRVTYDMAFGGNFYAILPIERLGIPFAKAEKERMLTAGLAIMDAVNERNRPVHPADPRISGCKHVQLTAPPAGGPADARNAMVIHPGWFDRSPCGTGTSARMAQLYARGELELGADYVNESLLGTLFTGRLEAGTEIAGLPAQIPTVTGRAWITGMSQYLLDPDDPFPAGFTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFM3</accession>
    <name>A0A0F7NFM3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hydroxypyruvate isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_28365</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the hyi family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018741.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_28365"/>
    <dbReference type="EnsemblBacteria" id="AKH85507">
        <property type="protein sequence ID" value="AKH85507"/>
        <property type="gene ID" value="AA958_28365"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_28365"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5978"/>
    <dbReference type="OrthoDB" id="1007505at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026040">
        <property type="entry name" value="HyI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006241">
        <property type="entry name" value="HyI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="3">
        <location>
            <begin position="26"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="2">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="2">
        <location>
            <position position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR006241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR006241-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH85507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="273" mass="28383" checksum="D0D14B0379057C9F" modified="2015-07-22" version="1">MGFGDQRFTVNISLLFTELPLLERPAAAAAAGFDAVELWWPWPDAPVPDPAELDALRTALDAAGTRLTGLNFYAGRLPGPDRGALSVPGAESERFRANLDVAAGFAAATGCTALNALYGNRVEGVTAAEQDLLALENLVLAARAADRAGAVLLIEALNEPESPHYPLLDAAAAVAVADKVDAASGLGNARFLMDLYHLSMNGADLEQVIDAHAGRTGHVQIADDPGRGAPGTGTLPLAALLDRLAAAGYDGHVGLEYKPGDRPSAESFGWLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NG30</accession>
    <name>A0A0F7NG30_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">AA958_33810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="AKH86384"/>
        <property type="gene ID" value="AA958_33810"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_33810"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.7140"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH86384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="81" mass="7895" checksum="871064BB0405909F" modified="2015-07-22" version="1">MADDTAEVTAAQAYRRLVRSVQAAMAEPGGSGPAAAVLAGPLADADRALAAAGLAGNEPRFFAVVRSVTAIPAPASGTAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NGD1</accession>
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    <organism evidence="7 8">
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            <taxon>Bacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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    <dbReference type="EnsemblBacteria" id="AKH86363">
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
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        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
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        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
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            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
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            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="168"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="233"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="307"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="360"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="405"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="464"/>
            <end position="492"/>
        </location>
    </feature>
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        <location>
            <begin position="16"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH86363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="505" mass="51191" checksum="86D182BC9E6AB711" modified="2015-07-22" version="1">MTTTTATKAGPRAWLGLSVLALPMLLASVDNSVLYLALPHLTADLEPSPTQVLWIMDVYGFMMAGFLITMGTLGDRIGRRRLLTVGAGAFGAASVLAAYAVSAEMLIAARILLGISASALAPSALALVGTMFTDARQRALAIGVFTACFMGGAALGPVVGGVMLENFWWGSVFLLGLPVALLLVLTARPLLPESGGEDGEGGGRLDPASVGLSLLAVIPLVYGLKELADEPDVRAAVAIAAGLAFGYAFARRQLRLAEPLLDLRLFRNRSFSAALVVLLFTMLVQGGCYFFFSQHLQLIEGFSPLKAGFWMAPPALALVAGSLLAPVMARTVRPAVVVGAGLAFSAAGFLYVAVSDDLVPLVIGFTVGFLGAAPVGALGLNLIVGSAPREKAGSASATAESSGEMGISLGIAVFGSLGAAVYTAGFDGPAGAPERAGESLADAEAAAAGLSGRLRGELLDAAHAAFGSGMTAVAVAAALVCAGLAVLAAVLLRHLRPIGSEDDGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NH55</accession>
    <name>A0A0F7NH55_9ACTN</name>
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        <submittedName>
            <fullName evidence="8">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomyces</taxon>
        </lineage>
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    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="AKH86779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020077.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_14990"/>
    <dbReference type="EnsemblBacteria" id="AKH86779">
        <property type="protein sequence ID" value="AKH86779"/>
        <property type="gene ID" value="AA958_14990"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_14990"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3159"/>
    <dbReference type="OrthoDB" id="1283908at2"/>
    <dbReference type="Proteomes" id="UP000034283">
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    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="FecCD"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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        </location>
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        </location>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="531"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="571"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="668"/>
            <end position="687"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH86779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NHA3</accession>
    <name>A0A0F7NHA3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_17060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020149.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_17060"/>
    <dbReference type="EnsemblBacteria" id="AKH86834">
        <property type="protein sequence ID" value="AKH86834"/>
        <property type="gene ID" value="AA958_17060"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_17060"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3587"/>
    <dbReference type="OrthoDB" id="1983082at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="147" mass="16524" checksum="37AAFCC1C5E2DBE1" modified="2015-07-22" version="1">MSDLRFTPPADDEALRDWRRVHNATIPTHHLSLDDVRDRAWRHRLELAYAGGVLVGCSTVRPPEDGTRTATVIARVLAEHRGRGIGEELYARGLFRAWELGAEQIATVVLSSNDSGLRFAHKHGFVETERYVLPGETIPWIDMKLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NHF5</accession>
    <name>A0A0F7NHF5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_17805</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020178.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_17805"/>
    <dbReference type="EnsemblBacteria" id="AKH86854">
        <property type="protein sequence ID" value="AKH86854"/>
        <property type="gene ID" value="AA958_17805"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_17805"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3748"/>
    <dbReference type="OrthoDB" id="1876612at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH86854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="125" mass="13060" checksum="4020123CF865AF60" modified="2015-07-22" version="1">MAGAAEAAARVLCDVRALADEPPVPSGVLWKLAEPGRQLDANLIRLPAHARIDTHAELDLDVLVLVVTGTGVLDTPEGPQPLAAGALLWLPHGSARSLSAGPEGLAYVTVHRRRPGMQIGRRADG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NHG3</accession>
    <name>A0A0F7NHG3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_32630</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for the transposition of the insertion element.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase mutator family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86182">
        <property type="protein sequence ID" value="AKH86182"/>
        <property type="gene ID" value="AA958_32630"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_32630"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6892"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001207">
        <property type="entry name" value="Transposase_mutator"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00872">
        <property type="entry name" value="Transposase_mut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0814">Transposable element</keyword>
    <keyword evidence="4" id="KW-0815">Transposition</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH86182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="56" mass="5936" checksum="1EFF75759E07E4F5" modified="2015-07-22" version="1">MLFVDAIHVKIRDGQVANRPVYVVMAVTVEGHRDILGIWAGDGGEARSSGGRSSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NHH6</accession>
    <name>A0A0F7NHH6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pilus assembly protein CpaF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_14360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GSP E family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020048.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_14360"/>
    <dbReference type="EnsemblBacteria" id="AKH86758">
        <property type="protein sequence ID" value="AKH86758"/>
        <property type="gene ID" value="AA958_14360"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_14360"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3022"/>
    <dbReference type="OrthoDB" id="473670at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022399">
        <property type="entry name" value="HlxAse/secretion_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03819">
        <property type="entry name" value="heli_sec_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T2SP_E" evidence="2">
        <location>
            <begin position="52"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH86758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="381" mass="39917" checksum="F286B5513BA09BDB" modified="2015-07-22" version="1">MVGAVRRRLAESGGEPTPAGVAAALRREGRLLGDTEVLAIAGALRSEMVGSGPLEPLLAQPDVTDVLVTAPDEVWVDRGCGLERVDVRFADADAVRRLAQRLAAVAGRRLDDARPWVDARLPDGTRLHAVLPPVAVGSACLSLRVVRRRAFSLAELAAAGTVPPGGEGLLRGLLDARLSFLVSGGTGSGKTTLLSALLSLVRRDERIVLAEESAELRPDHPHVVRLEARPANQEGAGEVTLQDLVRQALRMRPDRLVVGEVRGREVVDLLAALNTGHEGGSGTVHANAAGDVPARLEALGAVAGLDRPALHSQLAAGVSVLLHLVRDRRGRRRIAEVHVLERGAAGLVAAVPAAVWAAGGFARRAGWPRLERLLARGGGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NI04</accession>
    <name>A0A0F7NI04_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SpoU_sub_bind domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_33825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019609.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86387">
        <property type="protein sequence ID" value="AKH86387"/>
        <property type="gene ID" value="AA958_33825"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_33825"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.7143"/>
    <dbReference type="OrthoDB" id="1697536at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013123">
        <property type="entry name" value="SpoU_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08032">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00967">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="SSF55315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SpoU_sub_bind" evidence="1">
        <location>
            <begin position="32"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="268" mass="28167" checksum="742224A7E4D0E938" modified="2015-07-22" version="1">MTDTISSAANPLAKRVKLLAGRKHRRREGAFVVEGLQPVWSAVEAGWEVETLLVAPGLLTHQGALRMVEEQERAGVAVARLDAELFRRLVDRDGPSGIAAVLRSRDGGLDSLSTRPGSVFVALDRIANPGNLGTIIRTADAVGGAGVILIGDTVDPYAPAAVKASMGSLFAVDVVHAPDAGEFFSWAEEQGVAVVATSGSADEDHWSAAYDPPLAFLLGSEREGLPEDLLARASRRVRIPMVGTVDSLNIGVAASIMLYEARRHGGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NI10</accession>
    <name>A0A0F7NI10_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_19415</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020246.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_19415"/>
    <dbReference type="EnsemblBacteria" id="AKH86903">
        <property type="protein sequence ID" value="AKH86903"/>
        <property type="gene ID" value="AA958_19415"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_19415"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4082"/>
    <dbReference type="OrthoDB" id="1337662at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006764">
        <property type="entry name" value="SAM_dep_MeTrfase_SAV2177_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04672">
        <property type="entry name" value="Methyltransf_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017393">
        <property type="entry name" value="MTase_SAV2177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH86903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="284" mass="30784" checksum="DBF4A5B7A52AD54B" modified="2015-07-22" version="1">MSSEFDAATVTAPSAPRVYDFLLGGKDHYECDRLAAEKVRAVLPHAGVVAQQNRSFMHRAAGFLAEQGVTQYLDIGTGIPTSPNLHEVVQAQQPGARVVYVDNDQVVMRHAEALMQSTTEQGYVTCLEADLRDPHTILGVLRSRGDLDFREPIGLSLNAVLHFLPDADDPHGIVRTLMEALTESSWLTISHVTPDLAPKDVDAAVKYYRAAGIPAKARTRTEMARFFTGLAMAEPGITLVHRWRPQQPVPVPAATAGAAGAEDVRDEWVSCYGAVARKPAGYGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NI51</accession>
    <name>A0A0F7NI51_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_29865</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_29865"/>
    <dbReference type="EnsemblBacteria" id="AKH87129">
        <property type="protein sequence ID" value="AKH87129"/>
        <property type="gene ID" value="AA958_29865"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_29865"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6307"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH87129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="224" mass="24685" checksum="CD4CB7C9BCC29F09" modified="2015-07-22" version="1">MGRIVRGEHPPGTPLPPEPALCETFAVSRTVVREAVKVLQEKGLVQVRQGSGTTVTAPALWNMLDEQVLAASIAQDESMAILDDLVVTRRLLESDMANVAARLATPEVVGQLRTLVDRMDELVDDHVTYAEHDRAFHDVIMQSSGNRIARGVVRALESQVVNTARYMGHPERAMCVASNRGHRRIYERIAAHDPGGAAEAMFTHITEAWLVRRSAPGDPVRLER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NI82</accession>
    <name>A0A0F7NI82_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA alkylation repair protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_01200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019698.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86477">
        <property type="protein sequence ID" value="AKH86477"/>
        <property type="gene ID" value="AA958_01200"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_01200"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.264"/>
    <dbReference type="OrthoDB" id="1933111at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014825">
        <property type="entry name" value="DNA_alkylation"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08713">
        <property type="entry name" value="DNA_alkylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="256" mass="28002" checksum="10A505347D4C3EF2" modified="2015-07-22" version="1">MPQQHPGAAAAPDVPAAPEATAGAGAPAVPGSPLADTVLDRLTAAYPGAADPERAARSAAYLRGVAPFLGIPAPRRRELSRAVLAGTARPAEADCVAIALRCWRLPEREYHYFAVDYLRRHVRRCSSWSLPAVRHLIVTTSWWDTVDALAAHVVGGLVAADPALACAMDEWIEDGDLWVARTALLHQLRFKNATDTGRLFGYCLRRAGHRDFFVRKAIGWCLREYAKTDPRAVRAFVDAHRADLSPLSVREALRHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MXH6</accession>
    <name>A0A0F7MXH6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AMP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_00730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH80935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014301.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_00730"/>
    <dbReference type="EnsemblBacteria" id="AKH80935">
        <property type="protein sequence ID" value="AKH80935"/>
        <property type="gene ID" value="AA958_00730"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_00730"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.166"/>
    <dbReference type="OrthoDB" id="572620at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05931">
        <property type="entry name" value="FAAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040097">
        <property type="entry name" value="FAAL/FAAC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="16"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH80935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="557" mass="59054" checksum="63C4F4B790F75B1B" modified="2015-07-22" version="1">MTPAATIGAALLDLADSDPDRPLAYVEGSGDPVRLTAAELAERAGAAATTLAEHGVRRGDRVGVCMDTSADAYATLHGCFLLGAIPFVSEPPLATMRRQRWADRLRLLISRAEPRAVVVAPEFLDAVTEPCKEAGVAIVEPPFEGGLDLAAAQAKPDDIALLQFTSGTTGDSRGVTLTHESIFANAAAIGEHAYRAGDLIVSWLPMHHDMGLIGLNLAPLLHGLPVASMPPLSFAVRPERWLWAMHRYRGTFTSAPNFAYRMCASNIPDAKLAGLDLSAWRVAGNGAEVVQANTLRLFAERMAPYGYGERSMMPCYGMAEITLAATMCVPGEPLTTLTVSRDRLAADGEVVEAEPGAADAQELVSSGTPLTGMELRVVDDAGADLPDRKQGTILLRTASMMSGYYRQPEETAKVLGDDGWLNTGDQGFTDAGQTYVTGRIKDVVIIAGSNYHPYAFESAAAAVEGLRANSIAAVGCPDEERSTEALVLVVESKSHADAEAVAQIREGVIQAVSAETGLRPDRVEVVPRGTLPKTPSGKLQRRHVVDALVNGTLPTSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MYP8</accession>
    <name>A0A0F7MYP8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AA958_03175</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
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            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
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            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
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    <dbReference type="EMBL" id="CP011492">
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        <property type="gene ID" value="AA958_03175"/>
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    <dbReference type="PATRIC" id="fig|444103.5.peg.677"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="project" value="InterPro"/>
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        <location>
            <begin position="21"/>
            <end position="290"/>
        </location>
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            <begin position="273"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="364"/>
            <end position="415"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="7">
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            <begin position="449"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
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            <begin position="279"/>
            <end position="298"/>
        </location>
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    <feature type="binding site" evidence="6">
        <location>
            <position position="49"/>
        </location>
        <ligand>
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        </source>
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        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
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    <sequence length="799" mass="81437" checksum="A1DD9106690F296C" modified="2015-07-22" version="1">MSTPRGAEPDGRAAGARVGPYRLVRLLGAGGMGEVHLARAEDGRHVALKLVHEDLAADPEFRARFRQEVDAARRVLSFFTVPLVAAGPDDPAPWLATQYVPGPSLAQAVAADGPLPPRRLCSLAAALGEALVVVHAAGIVHRDLKPSNVLLADDGPRVIDFGIARAADATGLTGTGMAIGTLGYASPEQLVDDGPVGPAGDVYSLGAVLLYAATGRPPYGDAPAATLAYWTVHGTPDVTGVPAELADLVRACLAREPADRPTPTEVIAAARAAEAPDPEAPDPGSPHPPTPRSPAAGGAPAPPGGGATTSYPLAPPRSPAPTAAAGRGGLRRLAARPVALAATAAVTTAALLAGAFLLLPGDDGGPESAGMGTTSPRTPGDKDGDGDKGKGGGRTAAPEPSGPAADSPAGVTAAGDRVRDWRAPVSGTENQTALVGGWLTEHAAARTDSRGTLGLDPADGSRLWSVPPPKGSAVACRTSQGRTATHDGIGAVVYGDRADGLDDCGVVGAVDTAAGKLLWQRETGGSSTRSPAVGMSGGRLVIAAEKGVLGLDPRTGDERWQRTEGIDGCQLSDALTGPRTTVLMETCGRATNPNTVVELDSATGKERWRLELPDNAIESWPLTAEPVSVQLGRGGDGSKNALLVIDRTGKYHHEIPVHTPFGELNLNGAEDIALPWIGAYGDSVVVAAEAPSVVSPDRLAAIDAATGEIRWHKGLTFGAPSILAMDGESVTVRAEFGTEDEVHLVEYALDDGEVLGDGTLPAAFEDPTDRRVAAAGDRVVSFIGRRATGAEGYTVRDGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0B8</accession>
    <name>A0A0F7N0B8_9ACTN</name>
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        <recommendedName>
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        </recommendedName>
    </protein>
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        <name evidence="5" type="ORF">AA958_07330</name>
    </gene>
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        <name type="scientific">Streptomyces sp. CNQ-509</name>
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            <taxon>Bacteria</taxon>
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        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5 6">CNQ-509</strain>
        </source>
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    </dbReference>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="chain" id="PRO_5002519009" description="Fibronectin type-III domain-containing protein" evidence="3">
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            <begin position="39"/>
            <end position="707"/>
        </location>
    </feature>
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            <end position="541"/>
        </location>
    </feature>
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        </source>
    </evidence>
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    </evidence>
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        </source>
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        <source>
            <dbReference type="EMBL" id="AKH82070.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="707" mass="74140" checksum="1A0FB5DAE19CCCF1" modified="2015-07-22" version="1">MHKHRRTRKWGALGVALAVVTGTLVTVGVTYSSPEAEAVTPPVAMTADDLSTWQTNGVVWSMAESNGVVFAGGTFSAIRPPGAAAGTSETKAANFAAFNAATGEPTDCKLNFTIGSGTATVRALTVSPDGKTLYAGGEFGTVNGVSRSRVAAIDIASCTVKTGFNAGAVSARVYGLDAAASGRLYLAGDFKTVRGKSRVKFAAVNATTGALNSWKANAGPDRAGRVIEETPNGQHVVVGGDFNGLNGDASVHGLAVVRADTGATVRAFKGVSNNQNNPYELHWNSLVKGIHIDGSGIYTAHEGHGGGVFDGRLAMNLNSTFTQRWRDTCLGATQDVTVYKDVLYSVSHAHNCSSMGQFPELNERQHLLAESVDNPKPLLSWFPDTDDGPSGTEQIGPRVMVTSSSGGKDYMWVGGEFTRIQSNGNKLQQGLVRFANTPDSRKPVAGATGVTAANVDGGVRLRWKAGWDRDDSKLTYTIYRNGEALETKPTLDSNFWTLPQGSFTDSTVKPGTSYSYQITASDAVGNTTAKSAAVTVTTPGTPSETTVERTTTADAYVNGSATSTNYGAHNQLLVRKTSPYLSYLRFSLPQAPSGMTLKSAKLTLRTTNDASAGTPDTVSVQPVTGAWSESEVTYATRPALSSTVLGTFTGATELDTDYTASLSAAQLSGSLGDTLDVALTSDGTDAWWVRARETSYAPKLTLTFGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0S5</accession>
    <name>A0A0F7N0S5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_04620</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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    </dbReference>
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH81596">
        <property type="protein sequence ID" value="AKH81596"/>
        <property type="gene ID" value="AA958_04620"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_04620"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.974"/>
    <dbReference type="OrthoDB" id="1926714at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043215">
        <property type="term" value="P:daunorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900753">
        <property type="term" value="P:doxorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005894">
        <property type="entry name" value="DrrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01188">
        <property type="entry name" value="drrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="11"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="43"/>
            <end position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH81596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="336" mass="35026" checksum="78C23F9B04150B6B" modified="2015-07-22" version="1">MLGRMTTTYAVLSKALQKRYGDVHALRGLDLGIPEGTVCGLLGPNGAGKTTAIRVLTTLVAPDGGTARVAGYDVAAEPAAVRRAIGVTGQATSVDDDLSGRENLRLFARLLRLRGPAGRERADELLERFGLAEAAGRPARTYSGGMRRRLDLAASLLSRPRVLFLDEPTTGLDPASRGQIWAAVRELAAAGTTVLLTTQYLEEADRLADSVVVVDHGRAAVTGTPDELKQRVGAYAEVVVADDAALAAAAVVLGPLTGGEPRLDAERRAVGAAAYDPELTLPRVVRELDAAGVPVVDATLRRPTLDEVFLRLTGADAAGTAKDGSGTARHAKEAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N107</accession>
    <name>A0A0F7N107_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_01650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014447.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_01650"/>
    <dbReference type="EnsemblBacteria" id="AKH81083">
        <property type="protein sequence ID" value="AKH81083"/>
        <property type="gene ID" value="AA958_01650"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_01650"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.362"/>
    <dbReference type="OrthoDB" id="184508at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="863"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="974"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1218"/>
            <end position="1243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1005"/>
            <end position="1024"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="1583" mass="167965" checksum="DCA2464F28DB6C24" modified="2015-07-22" version="1">MYELSRIRLYSIGPAGARYADTVLDLRGVGAEVPQPAPAQGDFFAAEPTGPPRRPAPAGVLFLENGGGKSVLLKLIFSVMLPGHRNTLGGASSGVLRKFLLADDTGHVALEWQHTVTGEQIVVGKVSEWRGRQVSGDPRKFAEAWYSFRPGPGMGLDALPVAESAAVRPAAEGASGARGRRRTMKGFRDVLTEAGKAYPHLDVVWEEIHERWNEHLTRLGLDPELFRYQREMNADEGEAAGLFAVKNDSDFTHLLLRAVTDTRDTDGLADLVHGFAHKLGRRAELTAERDFTAGSLDLLEHIVTGAEQRARARDILGGAERRARALAARLTARAGAERARAAELAGQERTAAERVTAAESSRRDSELIAAELAYRHASLALAAAEKSAAGKRRELTDARTLHAAWQAAEAVLRHRAAADRAARVSAAIREAERDAAPALAARATAATGLVRALHAAARDGETLAAEQEERSAVLQQESETAHADAVAAATRAQRARSETDHLRQRLAEVEQETAEAVRAGRLDTDPAAPDTDPARAALVAGDAEKAAVAAWDEAREAARTAADHARETAAALARAELAAARAADAAEAAEAAYGTERRAAESLAGERRLVELLGLPEAEGEGGEQRALSAVEFDRAADELRTLLDARVTDDERRLFDLRTAAGDDARILAALGDGGLLPPGPDVLAVVDCLGEHGIPALPGWRYLAQAVDPADHAAVLDARPELVDGVVITDPDTHARAREVLREAALLPRSALAVGTAAALLAPPPTGERDGGVFLVPPNPAMHDERAADDERHALRARAADRDAQIRVLAARLAADRTLAARLASWRTGCPAGRLAELAAAAESARTASAAADETLTRARVEAEDAAAAAEETARAREERQDQAQRARRSADALAGLAHRLRERSGWQARLRELADEALEYEARAADCTARARAADEDRRDAQRAADDARRTARALRAERAEIAGVAEELEAEAADEAAEAGGGPSPGTLQEPDPAADGDTDPAEGDASRAEGGARRRARHAQAVAADAARASLPALREAYRAASQVYEKVGVGADLRAEQARAESEESAALAELNRLSNKVRTRAATLLAGPDGADAPSRQAAAVRAESVVHLLESRSAAASETLGRLRGDAERLAPAAGEAHTELPEDLVPAGAEQAQALLRSAAATAAERADELAAATEAHAGLRRACAAAEDAAGAFAETAAMLRDLLRGPAAGEEQDDAGEAEPFPGGLDGARQAAAESRRSLRGCAADLATAESALRDACDILVRHANSTRYEQVRTPARQQIRELPAAALPEHAAAWAAAFAPRLRVLTDELAQLERNRDGIVDRLRGLVESGLATLRAAQRLSRLPEGLGEWSGQEFLRIRFEDPDQATLSERLGEVIDEATRAAVRKNSDLRRDGTTLLLRGVDAAMAPKGVAVEILKPDAVLRAERVPVGQMGDVFSGGQLLTAAIALYCTMAALRGNDRGDDRHHHAGTLFLDNPIGRANATYLLELQRAVADALGVQLLYTTGLFDTTALAEFPLVIRLRNDADLRAGLKYITVEEHLRPGLPAQRDGEEPSVGEVTATRIFRRPPAVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N1G0</accession>
    <name>A0A0F7N1G0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PhoH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_09285</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015736.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_09285"/>
    <dbReference type="EnsemblBacteria" id="AKH82390">
        <property type="protein sequence ID" value="AKH82390"/>
        <property type="gene ID" value="AA958_09285"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_09285"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1959"/>
    <dbReference type="OrthoDB" id="445854at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036844">
        <property type="entry name" value="Hint_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027434">
        <property type="entry name" value="Homing_endonucl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004042">
        <property type="entry name" value="Intein_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004860">
        <property type="entry name" value="LAGLIDADG_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003714">
        <property type="entry name" value="PhoH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14528">
        <property type="entry name" value="LAGLIDADG_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02562">
        <property type="entry name" value="PhoH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51294">
        <property type="entry name" value="SSF51294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55608">
        <property type="entry name" value="SSF55608"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50819">
        <property type="entry name" value="INTEIN_ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DOD-type homing endonuclease" evidence="3">
        <location>
            <begin position="364"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH82390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="707" mass="77656" checksum="A543D64141469DAF" modified="2015-07-22" version="1">MTQTPVSRTPEEGQARAHITIPAKHPMVTVLGSGDSLLRVIEKAFPSTDIHVRGNEVSAVGASEEVTLVQRLFDEMLLVLRTGAPMTEDAVERTIAMLKSDRDDEAGGHHAPSEVLTQNILSNRGKTIRPKTLNQKRYVDAIDKHTIVFGIGPAGTGKTYLAMAKAVQALQSKQVNRIILTRPAVEAGERLGFLPGTLYEKIDPYLRPLYDALHDMLDPDSIPRLMAAGTIEVAPLAYMRGRAMPLFTKVLTPDGWRPIGDLEVGDLVIGSNGEPTPVLGVYPQGERDIYRVTAQDGSWTLCCGEHLWTVRTAADKRRNKPWRVLETQEMIGNLRAAHARRYELPLLTGPAQFPAREVPMDPYALGLLLGDGCITGKGTPSFTTSDPELATALEAALPGTRVRSRGGYNYLVNRVATPADSPGSVLTHPLKQALRALGLIGSKSYSKFVPDDYLYNTPEVRLALLQGLLDSDGGPVTQSDRTCRVQYTTASILLRDNVISLVQSLGGVAYTRRRAAEGRKPGRARGRDVHHRRDAHIVDIRLPEGIEPFRLARKREKYHAAGGGGRPMRFIDSIEPAGREETVCIQVAAEDSLYVTQDYLLTHNTLNDAFIILDEAQNTNPEQMKMFLTRLGFNSKIVVTGDVTQVDLPGGTKSGLRQVQGILDGVQDVHFSTLTSKDVVRHKLVSRIVEAYDKFDVKSRDDRNGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N1U2</accession>
    <name>A0A0F7N1U2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">30S ribosomal protein S4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rpsD</name>
        <name evidence="10" type="ORF">AA958_03230</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="6">With S5 and S12 plays an important role in translational accuracy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014713.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_03230"/>
    <dbReference type="EnsemblBacteria" id="AKH81354">
        <property type="protein sequence ID" value="AKH81354"/>
        <property type="gene ID" value="AA958_03230"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_03230"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.688"/>
    <dbReference type="OrthoDB" id="1211060at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01306_B">
        <property type="entry name" value="Ribosomal_S4_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_S4/S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001912">
        <property type="entry name" value="Ribosomal_S4/S9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005709">
        <property type="entry name" value="Ribosomal_S4_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018079">
        <property type="entry name" value="Ribosomal_S4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="PTHR11831"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831:SF4">
        <property type="entry name" value="PTHR11831:SF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00163">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01390">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01017">
        <property type="entry name" value="rpsD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00632">
        <property type="entry name" value="RIBOSOMAL_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_S4" evidence="9">
        <location>
            <begin position="2"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="S4" evidence="8">
        <location>
            <begin position="91"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AKH81354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="203" mass="23643" checksum="D37F3D7AFA2A1EDC" modified="2015-07-22" version="1">MNQPRPKVRKSRALGIPLTPKAAKYFESRPYPPGMHGRGRKQTSDYKVRLLEKQRLRAQYDISERQLVRAYERASKVQAKTGEALIVELERRLDALVLRAGLARTVYQSRQMVVHGHIEVNGRKVDKPSFRVRPDDVVKVRERSREKYPFQVAREGGYATDGETPRYLEVNLPALAFRLDREPNRREIPVICDEQLVVEYYAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N1Z0</accession>
    <name>A0A0F7N1Z0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Urease subunit beta</fullName>
            <ecNumber evidence="2">3.5.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Urea amidohydrolase subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ureB</name>
        <name evidence="3" type="ORF">AA958_00315</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>2 H(+) + H2O + urea = CO2 + 2 NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:20557"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.1.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nitrogen metabolism; urea degradation; CO(2) and NH(3) from urea (urease route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the urease beta subunit family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.5" evidence="2"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH80867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014233.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_00315"/>
    <dbReference type="EnsemblBacteria" id="AKH80867">
        <property type="protein sequence ID" value="AKH80867"/>
        <property type="gene ID" value="AA958_00315"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_00315"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.75"/>
    <dbReference type="OrthoDB" id="1755809at2"/>
    <dbReference type="UniPathway" id="UPA00258">
        <property type="reaction ID" value="UER00370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035550">
        <property type="term" value="C:urease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009039">
        <property type="term" value="F:urease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043419">
        <property type="term" value="P:urea catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00407">
        <property type="entry name" value="Urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01954">
        <property type="entry name" value="Urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002019">
        <property type="entry name" value="Urease_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036461">
        <property type="entry name" value="Urease_betasu_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00699">
        <property type="entry name" value="Urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51278">
        <property type="entry name" value="SSF51278"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00192">
        <property type="entry name" value="urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH80867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="103" mass="10755" checksum="E8191F94FFB524E8" modified="2015-07-22" version="1">MIPGEIRYGDGAVRLNEGADVVRLTVLNAADRPVQVGSHYHFAEANPGLEFDRAVARGRRLGIAAGTSVRFEPGVPVEVALVPIAGRRVVPGLRGETGGALDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N202</accession>
    <name>A0A0F7N202_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_03740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_03740"/>
    <dbReference type="EnsemblBacteria" id="AKH81448">
        <property type="protein sequence ID" value="AKH81448"/>
        <property type="gene ID" value="AA958_03740"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_03740"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.787"/>
    <dbReference type="OrthoDB" id="1271862at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019117">
        <property type="entry name" value="CRISPR-assoc_protein_Cmr3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09700">
        <property type="entry name" value="Cas_Cmr3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH81448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="465" mass="49730" checksum="3A107DF8385B1758" modified="2015-07-22" version="1">MPATPAASGMLDVTVTAHQPLALGVRPAGTAPAETRSHIPGSVLRGALATVWIRDHGLPMEVSPRLREEFVALFEGDVRYGPLFGSGSGIVPLSVKRCKYRCSSDAYVDTAFADGDEPSHCGLCDEAAPLTGGRGEVEFFGSRAGKLHVERTHLEIDDDSQVARDKELFTRRALSHRESDGTHRRFHGRIVPRGLPEAAADWLVRPRKLRMGGGRSTGGGVSFATAPAHPELPETATIVVLRLLSPAALTCPSGLPLDLGDRDAVRDALNDELADLLGTPITEVSRLWARREHVGGWHAASALPKATELALIPGSVLRLAFAEPPSPEALQALTARGIGLRRNEGFGAVEVAVSGWRAPGAAGPGDAASGGQEAVPDEAESHARVLHRTGHGRWFADQLRPYAAGRMAGEPPSTAVLGRSRLRDLPDGDRDDIERMLLDALPQVLDRTLAVLRFLNTLDEEKRQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N277</accession>
    <name>A0A0F7N277_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_04045</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014853.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_04045"/>
    <dbReference type="EnsemblBacteria" id="AKH81498">
        <property type="protein sequence ID" value="AKH81498"/>
        <property type="gene ID" value="AA958_04045"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_04045"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.848"/>
    <dbReference type="OrthoDB" id="162819at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519172" evidence="1">
        <location>
            <begin position="23"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="2">
        <location>
            <begin position="80"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH81498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="533" mass="57218" checksum="204DB49DCAE30A8B" modified="2015-07-22" version="1">MKKAVQRFAPPLGAAMATVLLAAGCGSDSGSGAGSGDAVVMGMTDEVSAIDPAAGYDVGSWLVFNNVFQSLLSFPKGSTEPEPEAAEECTFEDADSRVYTCKLQDGLKFSNGSELTSEDVKFSFERTIGIDDPAGPAVMLDSVGSIETPDELTVTFRLDYPDATFPMKIASGAGSIVDSESYPKDKLRDDGKAVGSGPYKLDSYQEGKEAKFSVSSGYKGTAKVQNSGMTLKLYGGTGGDEKLKADLESGDIDLAYRGLAMKDIAELQDQAGAGQKIQLVEGTSAEVQHLVFNMDDPVAGDPAVRKAFAYLIDRNALVREVYEGTAEELYSIVPAGITGHNTAFYDTYGDRPDPSRAEQVLREAGIDEKVRVTLFATPERYGPGTVPSFELIAKQLNDSGLFQADVESVPLDEFEKGVEKGSYGVYVKGWVPDYPDPDNFTAPFFGEGNVLANNYNPGRITSELIPATAAQSERTATVDDYGELQDIVADQLPVIPLWQGKQYAAARENILGLEWTLDASTVFRFWEISKGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2L7</accession>
    <name>A0A0F7N2L7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_08410</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015600.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH82251">
        <property type="protein sequence ID" value="AKH82251"/>
        <property type="gene ID" value="AA958_08410"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_08410"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1776"/>
    <dbReference type="OrthoDB" id="2216261at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH82251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="97" mass="10169" checksum="46B3B3549A6CAB51" modified="2015-07-22" version="1">MRSRPAFLRPVRRTRAGDVAGYTAAVIALVAGGAIFTRSILTWTRGPVVAIAAILLTGWAVDKVRARRHPGDDEPDDGRDGDGGGGDRGDGGEGEDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2M1</accession>
    <name>A0A0F7N2M1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Calcium-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_08435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015605.1">
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_08435"/>
    <dbReference type="EnsemblBacteria" id="AKH82256">
        <property type="protein sequence ID" value="AKH82256"/>
        <property type="gene ID" value="AA958_08435"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_08435"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1781"/>
    <dbReference type="OrthoDB" id="1913389at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13405">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="1">
        <location>
            <begin position="6"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="1">
        <location>
            <begin position="57"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="1">
        <location>
            <begin position="135"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="187" mass="20561" checksum="F2476F467E59A9EC" modified="2015-07-22" version="1">MEVSTFLARKLARRFRTYDTDGDGYVDRADFERAARQLGEEFGHGPDSPARRRVEELCLGVWERLVRAADTDGDGRVDQAEYAAAFAAGLLETPEDFAAGYGEFLEAIMAIADVDGDGALGQEEHVRWTGALMNLPAHDAREVFRRLDTDGDGRVTTADLLAAIRDYYFDDDPASAGSWLLGPLDPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-08-12" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2R4</accession>
    <name>A0A0F7N2R4_9ACTN</name>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_05230</name>
    </gene>
    <organism evidence="3 4">
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        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asp23 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH81699">
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        <property type="gene ID" value="AA958_05230"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_05230"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1098"/>
    <dbReference type="OrthoDB" id="2035639at2"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005531">
        <property type="entry name" value="Asp23"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03780">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH81699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="161" mass="16811" checksum="316E5A08CB1082E1" modified="2015-07-22" version="1">METVSSESTVSEVPREPAAAPPKVLGTRRGTGDPATRGRTTIADGVVEKIAGLAARDVVGVHAMGSGLARAAGAVRDRAPGSTRSVTGVRAEVGEVQTALDLEIVVDYGVSITELARAVRENVISAVERMTGLEVVEVNIAVTDVKLPDDEEEEAEQPRLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2Z1</accession>
    <name>A0A0F7N2Z1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_13075</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016338.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH83005">
        <property type="protein sequence ID" value="AKH83005"/>
        <property type="gene ID" value="AA958_13075"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_13075"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2751"/>
    <dbReference type="OrthoDB" id="1660161at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH83005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="233" mass="24861" checksum="6F9A7B7941A8D3A8" modified="2015-07-22" version="1">MTAADGARKIPYAFSYRVPDEFVRLPEAGTLAGWDEALGRLMPDADEDRLAAAGLQMRRFLPLLSEGGETTVLTAMCAGTEEVDGDERLSMGLLAVSAQASDHDDQLMAAEGIYRAKEQKFFAGEREPRELDYELGKGLQGTQDMLLAVKLPGGPGVMSASLRSLTLPGGDAETPAPVIPFASLQLIMPAPRGYCAYVTIATPSVFLLDSYCMRLAHVGRTFGFDVPAGGDLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3A4</accession>
    <name>A0A0F7N3A4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chorismate mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_06050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015192.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_06050"/>
    <dbReference type="EnsemblBacteria" id="AKH81839">
        <property type="protein sequence ID" value="AKH81839"/>
        <property type="gene ID" value="AA958_06050"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_06050"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1264"/>
    <dbReference type="OrthoDB" id="1980002at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004106">
        <property type="term" value="F:chorismate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046417">
        <property type="term" value="P:chorismate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Chorismate_II_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010951">
        <property type="entry name" value="CM_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036979">
        <property type="entry name" value="CM_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="CM_II_prokaryot"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00830">
        <property type="entry name" value="CM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48600">
        <property type="entry name" value="SSF48600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01795">
        <property type="entry name" value="CM_mono_cladeE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51168">
        <property type="entry name" value="CHORISMATE_MUT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chorismate mutase" evidence="1">
        <location>
            <begin position="17"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="119" mass="13056" checksum="43C507E82DD728B1" modified="2015-07-22" version="1">MTDHSTSPSAMDGLSDSDVRAELDRLRDSIDNIDAAVVHMLAERFKCTQQVGRLKAAHHLPPADPAREARQIIRLRELAESAKLDPAFAEKLLNFIIAEVIRHHETIANSAAPESPSAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3T2</accession>
    <name>A0A0F7N3T2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_07150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_07150"/>
    <dbReference type="EnsemblBacteria" id="AKH82034">
        <property type="protein sequence ID" value="AKH82034"/>
        <property type="gene ID" value="AA958_07150"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_07150"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1498"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="278"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="472"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH82034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="766" mass="78187" checksum="26EB992993B30377" modified="2015-07-22" version="1">MDQQAVTARGAAKPPPPADTVPPPVDVEQAEAAVVEHYAHLTRLAYLLLPAEEDRGRRVLAAHGLVQRSLPRGRTAPGAPDCGVHDGVPPGAVPGQRADGSGGAARGPGAADAAHGAEVRFGPGAPWRNDGDAGAGYAYVRLRIVRAALDAGRPRRPLRLPRPGGLPSPLPRLWGLRLHPRPGGSDELALDRALAALPAPARAAYVLRGLEALPDPAVRRLLAAAGAEDPGAALAAADRVAEPPGSAERRLLLSPEFDPCALQARPTDLLRRRQHTRAALAAAAALVAVVALLGVPGTGGGADDAAAAPYARNAFAEQALDPARLALAGRDDWQRTGRADFAAWPARGARTRDAALLRRALAVWARPGESVRVSATPGTAAGPPAGPPRLLYAGDVDRATVVLFHDGLRLVRYAEVRGEPGAAVLDFARADAADAASALAVVVGRTDGKVRYLTAPWVSGVSLRELLDPAAEAERVDRDTDGVTAPVPSPPLPTTAPAEPGAATPGDEPDTGGAQHGTRAPGGAADGAADDTATTDAPAAQSPPDGTPGGSRDTAEQPCTTWPGLELRTRPSAGAGAPAQLTTDLGELVPARLTYGPPAAATDVAGAAARDRWARTACHLAALRAHGVRSVNSWTFAGQPLPEAGGTAAWVCTRADTWRGTGGVTLAQFQPPATDPLQQGAVAARARDTTACGVRAPHALAGVLWKARSGRWYVLAAGSRDVTSVTASGGVSGVAEGRFLATAADRGARARLTATLPDGTTLRPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3Y9</accession>
    <name>A0A0F7N3Y9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_15240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016659.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_15240"/>
    <dbReference type="EnsemblBacteria" id="AKH83345">
        <property type="protein sequence ID" value="AKH83345"/>
        <property type="gene ID" value="AA958_15240"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_15240"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3210"/>
    <dbReference type="OrthoDB" id="1918376at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005325">
        <property type="entry name" value="DUF308_memb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03729">
        <property type="entry name" value="DUF308"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="220"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="243"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH83345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="279" mass="28731" checksum="431F0DCD8B5B4444" modified="2015-07-22" version="1">MSTDPAPHRGRPDRPGPSPDADADADADASGERIRPVGDRTRRVEEPGGAATAPGEHAPRERRLSVVAGDEDTGPPPGGDPARTAHHDRGAVPEGPLGILARGAWQAVLLAGVAALVLGALTLAWPGETLRVVGILFGLYLLVIGVMQLVAAFGTHASTALRVMAFISGALCILLGLLCFRSALQSVLLLALWIGIGWLFRGITQAVAAGSDEAMPARGWQIGLGVISALAGIVLIASPLTSIAILTYLAGVWLLAVGVIEIATAVRIRHRAKQLPAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N415</accession>
    <name>A0A0F7N415_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_07625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015473.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_07625"/>
    <dbReference type="EnsemblBacteria" id="AKH82123">
        <property type="protein sequence ID" value="AKH82123"/>
        <property type="gene ID" value="AA958_07625"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_07625"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1603"/>
    <dbReference type="OrthoDB" id="1757088at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="149"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="236" mass="25456" checksum="D04CE77096B3D777" modified="2015-07-22" version="1">MELRFETRRSDSPWVDTVWSCTSEQVTAMTSVAGVHWGLVFWRQDGRAYAGVTGPGTRTGTAPVPEGAAFTGIEFALGTSLRALPTPALVDGGVELPDTTRRTFRLDGARWETPRADDAEALVGRLVRAGIVVCDPLVAEVLRGHRPAVSERTVERRFRAATGLTRGAVRQIARARTAAELLALGAPAAFVVAKLDYFDEPHLARALRSYVGRTARQLREGAGGAIALHPDQRVTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N465</accession>
    <name>A0A0F7N465_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_04870</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014992.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_04870"/>
    <dbReference type="EnsemblBacteria" id="AKH81637">
        <property type="protein sequence ID" value="AKH81637"/>
        <property type="gene ID" value="AA958_04870"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_04870"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1025"/>
    <dbReference type="OrthoDB" id="1833499at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH81637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="223" mass="23149" checksum="C6EA245E4D7B8330" modified="2015-07-22" version="1">MTVEIALHRARVRYGPLEALHGIDLPVPAGRLTVLLGRNGSGRTTALRALAGTVPLAAGRVVWRGEDVTRMPAYARARRGLSLTPEVRAVFGSLTVTENLRLAVPGGDTGPALAAYPELARLLPRRAGTLSGGEQRMLAVARALLSPARLVLLDEPGQGMSAAVAARTHELLGGLAATVVVAEQSLPPGLAAAATVVHELRRGNVVFSGEPAEAGAPWHTAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4H4</accession>
    <name>A0A0F7N4H4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_16565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016860.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH83555">
        <property type="protein sequence ID" value="AKH83555"/>
        <property type="gene ID" value="AA958_16565"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_16565"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3486"/>
    <dbReference type="OrthoDB" id="2104335at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="4"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="98" mass="11048" checksum="2655B52A15FB25DA" modified="2015-07-22" version="1">MSESDELRRRVETLEARVDAVHDQMSQTHAMVAINDRDVAELKLEMRAHRKVLEALRETQLEQSRRIDALDGKVTEGFATVLAAVQALADRLPEEPAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4K9</accession>
    <name>A0A0F7N4K9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6351 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_12565</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016261.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_12565"/>
    <dbReference type="EnsemblBacteria" id="AKH82926">
        <property type="protein sequence ID" value="AKH82926"/>
        <property type="gene ID" value="AA958_12565"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_12565"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2640"/>
    <dbReference type="OrthoDB" id="168485at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045556">
        <property type="entry name" value="DUF6351"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19878">
        <property type="entry name" value="DUF6351"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519776" description="DUF6351 domain-containing protein" evidence="1">
        <location>
            <begin position="28"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6351" evidence="2">
        <location>
            <begin position="39"/>
            <end position="709"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH82926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="718" mass="76879" checksum="1D1C10E48F28233F" modified="2015-07-22" version="1">MRPRRALLVPLSAALAALLALPLTAQAAAPQASQRIDLDVLSGRPGSVTGGDALLRVAAADPAAVEIRLNGEDVTPLFAPDGPGAVSGVVDGIRDGRNTVTATAPGHRAARLTLTGHPAQGPVFSGPHQQPFVCETGTFRLPVVGGTLGDPLDDDCAARTRVDYFYRNTAGVYTAWPAGAADYPADLGRTTTSTGRAVPFIVRMETGTANRGIYQSTILHDPLAEPDPDPRSRPAGWNGRAVYTLGGGCIGGWYRQGNTTGGVTDTHMLGRGYAVMSSSLNVFGANCHDLTAAETAMMVKERFTEAYGPVDHTIGFGCSGGSYQAYQIVDNYPGILDGILPACSFPDVGFAMTNRVTDTRLLTEYFAGDTDLAWTEEQKRAVTGFASYAVATGTQGDAARIDPTGNCGVLPEELRYDPETNPRGARCDLYDHAINVYGPDPRTGFARRPLDNVGVQYGLGALAAGTIGKEQFLELNERVGGYDHDARIVDARTTADPIATRTAYRTGRLTNGGGGLADVPVIEYRAYVDDAPRGDTHLRYYSLSMRKRLVKANGTAANMVSLMEDNRYGGQSTASPLVRHSLAMMDRWLTNLGTDTSAAPRIDKIVAAKPAELREGCNTRDAEPRFVAEALDRDPDSTCEKLYPSNSFPREVAGEDIATDVIKCRTEPPRRDTYAKEYGVTWTDAEWRRLRAVFDRGVCDYSGTGVGQQGLAGTWLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4L7</accession>
    <name>A0A0F7N4L7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_12655</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016271.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH82936">
        <property type="protein sequence ID" value="AKH82936"/>
        <property type="gene ID" value="AA958_12655"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_12655"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2659"/>
    <dbReference type="OrthoDB" id="1826886at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="7"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH82936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="194" mass="21525" checksum="DF7BDEC738D5E91A" modified="2015-07-22" version="1">MDDAENEAARERVLEAADRLFYAHGIRAVGMDRIRDTAGVSLKRLYRCFASKDELVEAYLRRRDRWVRGELADFVAKEATGLPRERVLAVFDWLEWWFGRPDFRGCPFTNAFNEIGADSARAAAAVRDHQLAVSAYLRGLIAATGVPDPDAVTNRFVILYAGSLTFAAISRSTEPARYARETAAAILRPDAAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5G9</accession>
    <name>A0A0F7N5G9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_10775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015968.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH82628">
        <property type="protein sequence ID" value="AKH82628"/>
        <property type="gene ID" value="AA958_10775"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_10775"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2266"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="72" mass="7124" checksum="07741D5A20B834B0" modified="2015-07-22" version="1">MLLLSQAGAAIALVAICVTALALGVLVALTAPVPRSRRAPALTAEHVVAARPDGIAAPAADRRPVGAQSAPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5M6</accession>
    <name>A0A0F7N5M6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_11270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016052.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_11270"/>
    <dbReference type="EnsemblBacteria" id="AKH82714">
        <property type="protein sequence ID" value="AKH82714"/>
        <property type="gene ID" value="AA958_11270"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_11270"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2375"/>
    <dbReference type="OrthoDB" id="1538300at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="11"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="200" mass="21674" checksum="31117D2E0899B3F9" modified="2015-07-22" version="1">MDPITLVTERLLLRPAEPGDVDAVLAACQDPGIQRWLPVPSPYEREHAEEYVLKIIPAGWREDRQYDLVLTDLESGALVGSAGVGRTAGPEERVRSVGFWTAPGHRGHGYAGEAVAALARWAFTELGADRLEWLAQVGNEGSRSVARKAGFTMEGVLRSRIIHQGVRRDAWVASLLPSDLGLAPQVPYGAPATYPARTAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5Q3</accession>
    <name>A0A0F7N5Q3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MDMPI_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_07810</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015507.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_07810"/>
    <dbReference type="EnsemblBacteria" id="AKH82157">
        <property type="protein sequence ID" value="AKH82157"/>
        <property type="gene ID" value="AA958_07810"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_07810"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1643"/>
    <dbReference type="OrthoDB" id="2055578at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017517">
        <property type="entry name" value="CHP03083_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017520">
        <property type="entry name" value="CHP03086"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024344">
        <property type="entry name" value="MDMPI_metal-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11716">
        <property type="entry name" value="MDMPI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03083">
        <property type="entry name" value="TIGR03083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03086">
        <property type="entry name" value="TIGR03086"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MDMPI_N" evidence="2">
        <location>
            <begin position="17"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH82157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="205" mass="21418" checksum="2043F0F5AEA14D20" modified="2015-07-22" version="1">MTDANPAAPAAHPDLGPQTRVVARLAAGVPDDRLEDPTPCEGMAVRHLLGHLAGLTVAFRDAGRKDLGPTTGTDPNSAPRPDIGPGWREELARRLPELAEAWHDPAAWEGDTQAGGVALPAAVAGRVALNELVLHGWDLARATGRPYEPDDEALRVSYDLLAATPGGPAREGMFGPVVAVPEDAPLLDRVAGLSGRDPGWTPPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5Z7</accession>
    <name>A0A0F7N5Z7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MFS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_19550</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017298.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH84005">
        <property type="protein sequence ID" value="AKH84005"/>
        <property type="gene ID" value="AA958_19550"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_19550"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4120"/>
    <dbReference type="OrthoDB" id="1345431at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="307"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="346"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="369"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="21"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH84005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="408" mass="40504" checksum="F36EAB13FFBCFBB4" modified="2015-07-22" version="1">MITTPACEPAPPPQRSRHWPAITAAALTATVTVMPGFAIGALAPAIETSLDISRTTLGLALSSFYAATAVGSPIAKRIAARLPVHAVLSAAALIAAAVLLAAAQAHGPTLLTAALVVGGLGNALVQPAAGRLIAARTPTHRRSLAAGIVGAALAAATLIPGLLVALVLPDYGWRSALVTAGLLALMPAALTARMRTPATPLPPPPAPAPRRQARATLMMWSLAAALSATGNNAVATYFVRLGTDSGLPARTAGNLLALSALLAIAVRITAGILTDRAPRRNPAVIASMMLAGGLGLALISTGTPATFVLGAMLAFSAGWGWTGLLLATALHLVPNRTENAGHTVQVGIYTGAAVAPFAFAALSDTVGHTAATLACAAAAVAAAGAVVTGSLLFAGARRGGRSGYLGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6D0</accession>
    <name>A0A0F7N6D0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_12475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016249.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_12475"/>
    <dbReference type="EnsemblBacteria" id="AKH82914">
        <property type="protein sequence ID" value="AKH82914"/>
        <property type="gene ID" value="AA958_12475"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_12475"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2621"/>
    <dbReference type="OrthoDB" id="807474at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005693">
        <property type="entry name" value="Mce"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01782">
        <property type="entry name" value="MCEVIRFACTOR"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00996">
        <property type="entry name" value="Mtu_fam_mce"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MlaD" evidence="1">
        <location>
            <begin position="44"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="341" mass="36401" checksum="740ABF1ACBEB2A4D" modified="2015-07-22" version="1">MRVPRLKPVRERSPVAVGLVGLLVLALGGFAAYRADALPGVGGGTSYTAHFSEAAGLRSGDEVRVAGVKVGEVDGVGLDGPRVAVDFTVRDAWIGDRSTAAIAIETLLGEKYLAVDPLGSVRQDAGQPIPVERTTSPYDVTQAFQDLSSTVGELDTTALAESFEVISETFEDTPPNVRKAANGLADLSQTISSRDAELARLLSGSAEITRTLKEQNDTFETLLKDGNDLLAEVRARRDAIHALFTGTRDLAKELDGLVEENEEQIGPVLDALDRVTGVLRANEKNLDKALATAGPYYRLVGNTLGSGRWFDSYLCGLVPREYAPDVVPDRGCRPPEPKGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6S9</accession>
    <name>A0A0F7N6S9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_17980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_17980"/>
    <dbReference type="EnsemblBacteria" id="AKH83781">
        <property type="protein sequence ID" value="AKH83781"/>
        <property type="gene ID" value="AA958_17980"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_17980"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3782"/>
    <dbReference type="OrthoDB" id="827116at2"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="511" mass="56621" checksum="F47E71C5F3B123CA" modified="2015-07-22" version="1">MTTHDTPPITPRRTYLIGKARPNAIVGRNRETGEIGMIIGGAFLGMMCGLLVPVLTLRIVLLMGFPLLALAAVYVPYRGRTFYRWFEISRSHRRLLRSGAAVYRSGAQEAGTRLNGEEVAVGTPPGIGRISWMVAPFGPDEIAVLLHADRRTVTAVIEIEGPGVGLRDSEDQEALVDRFGTLLKHAANGDGFVRRLQMLARTLPADPDAHAKDVSQRGDPRAPQWIKGSYDQLQSMVSTSSEQHRAYLVACMPYTRDLGQEATVMGRATKQSRDECIAVIMARELGDICARLAEADIRVRQPLGIARLSALVHSMYDPDHPIDHIQAMTQRNAWPAELDAVNPQYLRAKTRESATRDPWCHSTAWVKEWPMTPVGVNFLAPLLVHTPDVIRTVAVCMDLEPTEVAIERMLTEKTNDDAEASRQAKMNRVVDPRDIAHHERIDQRGEDLASGAAGVNIVGYLTVSARSPEALARDKRTIRASAGKSYLKLEWCDREHHRAFVNTLPFATGIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N725</accession>
    <name>A0A0F7N725_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_14235</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_027773295.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_14235"/>
    <dbReference type="EnsemblBacteria" id="AKH83198">
        <property type="protein sequence ID" value="AKH83198"/>
        <property type="gene ID" value="AA958_14235"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_14235"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2996"/>
    <dbReference type="OrthoDB" id="1832232at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="4"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="257"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="42"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH83198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="279" mass="30252" checksum="998EBA02B6BBD43A" modified="2015-07-22" version="1">MTALEITGLQKNYVDAYSGEEVTAIGDVSFSVDEGEFVSVLGPSGCGKTTVLNIVAGFVTLTEGEVVVDGQAVSGPGPDRGVVFQSHALFPWKTVLGNVVFGLRMKGVPRPERDAKGKEFLELVGLGGFEHKYPHELSGGMQQRLGVARVLANEPAVMLMDEPFASIDAQTRRKLQEDLTRIFEKRRPTVFFVTHDVDEAVFLSDRIVVLSKRPSRVREIVTVDLPRPREWRTALEMPEFREIANRVNELLVDDEGAAAGTDEGPGGATDAEGTAVAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N790</accession>
    <name>A0A0F7N790_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_11050</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016015.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_11050"/>
    <dbReference type="EnsemblBacteria" id="AKH82677">
        <property type="protein sequence ID" value="AKH82677"/>
        <property type="gene ID" value="AA958_11050"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_11050"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2327"/>
    <dbReference type="OrthoDB" id="1688736at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="101"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="298"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="97"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH82677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="329" mass="35853" checksum="5F00A0A6ECD534B6" modified="2015-07-22" version="1">MTAVVSKDAARPAGGSGTPSRRRWRTRRGRTHRTSTEGSYALYLLPGGLAFLIVIIVPFVMNTGISFTDWSGVGTPEFTGLENYDRLLGDDDFWESFRHSLAMVAAMALVPTAIGLVLASALFDFVGKHAGSRWVAAVRACFYLPQVLPIAVAGIVWSWILAPESGSLNELLGAVGLDALQQDWLGDPDWALYSVMTVMVWVQIGFPLVIFMSGLQRVDPALHEAAELDGAGWWRRFWHVTLPQLRPEIAVVLLWCTIAALKVFGMVYVLTGGGPGGATNVPSYFAYQNFFENFQAGYGAAISTVLTALILVLAVVALKLQTRAEDENR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7A8</accession>
    <name>A0A0F7N7A8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosome hibernation promoting factor</fullName>
            <shortName evidence="2">HPF</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">hpf</name>
        <name evidence="5" type="ORF">AA958_11285</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Interacts with 100S ribosomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HPF/YfiA ribosome-associated protein family. Long HPF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016054.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_11285"/>
    <dbReference type="EnsemblBacteria" id="AKH82717">
        <property type="protein sequence ID" value="AKH82717"/>
        <property type="gene ID" value="AA958_11285"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_11285"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2378"/>
    <dbReference type="OrthoDB" id="1766263at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044238">
        <property type="term" value="P:primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00552">
        <property type="entry name" value="RaiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00839">
        <property type="entry name" value="HPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034694">
        <property type="entry name" value="HPF_long/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036567">
        <property type="entry name" value="RHF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003489">
        <property type="entry name" value="RHF/RaiA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032528">
        <property type="entry name" value="Ribosom_S30AE_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038416">
        <property type="entry name" value="Ribosom_S30AE_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16321">
        <property type="entry name" value="Ribosom_S30AE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02482">
        <property type="entry name" value="Ribosomal_S30AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69754">
        <property type="entry name" value="SSF69754"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00741">
        <property type="entry name" value="yfiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="Ribosom_S30AE_C" evidence="4">
        <location>
            <begin position="164"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH82717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="239" mass="26627" checksum="5854C58C406531A9" modified="2015-07-22" version="1">MDIVVKGRKTEVPERFRRHVAEKLKLDKIQKFDGKVISLDVEVSKEHNPRLADRCDRVEITVHSRGPVVRAEAAAADPYAALDLATAKLEARLRKQHDKRKTRRPGKDRRTAAEVGEVVAHAAQLTDDGELMTPSMETIAEGEPLESGSRRHRRGPLEVDGDGPLVVREKTHAAPPMTLDQALYEMELVGHDFYLFVDSDKKLPSVVYRRHAYDYGVIHLDPYLIEESLPDGAGGALGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7B8</accession>
    <name>A0A0F7N7B8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_14805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BlaI transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_14805"/>
    <dbReference type="EnsemblBacteria" id="AKH83279">
        <property type="protein sequence ID" value="AKH83279"/>
        <property type="gene ID" value="AA958_14805"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_14805"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3120"/>
    <dbReference type="OrthoDB" id="2027769at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005650">
        <property type="entry name" value="BlaI_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34134">
        <property type="entry name" value="PTHR34134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03965">
        <property type="entry name" value="Penicillinase_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="130" mass="14527" checksum="8E174301AAB9460D" modified="2015-07-22" version="1">MRRSGELERAVMDVLWDAGRPRTAKDVLDALPDRALAYTTVITVLDRLAQKGTARRERIGRSWHYTPAASRESYVTSLMMDVLAQAGDRDAVLAHFARSVSGPEADVLRDALAREADEHHGSDDKGKRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7D7</accession>
    <name>A0A0F7N7D7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Urocanate hydratase</fullName>
            <shortName evidence="9">Urocanase</shortName>
            <ecNumber evidence="4 9">4.2.1.49</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Imidazolonepropionate hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">hutU</name>
        <name evidence="13" type="ORF">AA958_11550</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the conversion of urocanate to 4-imidazolone-5-propionate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>4-imidazolone-5-propanoate = H2O + trans-urocanate</text>
            <dbReference type="Rhea" id="RHEA:13101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17771"/>
            <dbReference type="ChEBI" id="CHEBI:77893"/>
            <dbReference type="EC" id="4.2.1.49"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
        <text evidence="9">Binds 1 NAD(+) per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Amino-acid degradation; L-histidine degradation into L-glutamate; N-formimidoyl-L-glutamate from L-histidine: step 2/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the urocanase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.49" evidence="4 9"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016098.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_11550"/>
    <dbReference type="EnsemblBacteria" id="AKH82762">
        <property type="protein sequence ID" value="AKH82762"/>
        <property type="gene ID" value="AA958_11550"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_11550"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2430"/>
    <dbReference type="OrthoDB" id="100619at2"/>
    <dbReference type="UniPathway" id="UPA00379">
        <property type="reaction ID" value="UER00550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016153">
        <property type="term" value="F:urocanate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019556">
        <property type="term" value="P:histidine catabolic process to glutamate and formamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019557">
        <property type="term" value="P:histidine catabolic process to glutamate and formate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00577">
        <property type="entry name" value="HutU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023637">
        <property type="entry name" value="Urocanase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035401">
        <property type="entry name" value="Urocanase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038364">
        <property type="entry name" value="Urocanase_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023636">
        <property type="entry name" value="Urocanase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035400">
        <property type="entry name" value="Urocanase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035085">
        <property type="entry name" value="Urocanase_Rossmann-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036190">
        <property type="entry name" value="Urocanase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12216">
        <property type="entry name" value="PTHR12216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01175">
        <property type="entry name" value="Urocanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17392">
        <property type="entry name" value="Urocanase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17391">
        <property type="entry name" value="Urocanase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001423">
        <property type="entry name" value="Urocanate_hydrat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111326">
        <property type="entry name" value="SSF111326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01228">
        <property type="entry name" value="hutU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01233">
        <property type="entry name" value="UROCANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0369">Histidine metabolism</keyword>
    <keyword evidence="7 9 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 9" id="KW-0520">NAD</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Urocanase_N" evidence="11">
        <location>
            <begin position="7"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Urocanase" evidence="10">
        <location>
            <begin position="136"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="Urocanase_C" evidence="12">
        <location>
            <begin position="352"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="411"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="48"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="178"/>
            <end position="180"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="244"/>
            <end position="245"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="265"/>
            <end position="269"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="274"/>
            <end position="275"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="323"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="493"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AKH82762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="563" mass="60494" checksum="81229365854AD7CB" modified="2015-07-22" version="1">MAGPRPVRAPRGNQPSARGWQQEAALRMLQNNLDPEVAEHPDKLVVYGGTGKAARDWDSFDAMVRTLTTLGPDETMLVQSGRPVGVMQTHEWAPRVLIANSNLVGDWATWEEFRRLEALGLTMYGQMTAGSWIYIGTQGILQGTYETFAAVAEKLSRENKHSGGTLAGTLTLTAGLGGMGGAQPLAVTMNDGVALCVECDPSRIERRLEHGYLDVKADSLEHALRLATEARDARRPLSVGVLGNAAEVVPRLLAEGAPIDIVTDQTSAHDPLAYLPLGVDFADMAAYAAEKPADFTARARESMARHVEAMVGFQDAGAEVFDYGNSLRGEARLAGYARAFDFPGFVPAYIRPLFSEGKGPFRWAALSGDPKDIAATDRAILDLFPGNESLARWIRLAGERVRFQGLPARICWLGYGERDRAGERFNDMVASGELAAPLVIGRDHLDCGSVASPYRETEAMRDGSDAIADWPLLNAMVNVASGASWVSLHHGGGVGMGRSLHAGQVTVADGTALAGEKIRRVLTNDPGMGVIRHVDAGYERAEEIAAERGVRVPMRENAESGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7F2</accession>
    <name>A0A0F7N7F2_9ACTN</name>
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        <submittedName>
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        </submittedName>
    </protein>
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    </gene>
    <organism evidence="2 3">
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
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        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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    <dbReference type="EnsemblBacteria" id="AKH82777">
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    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_11640"/>
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    <dbReference type="OrthoDB" id="2093976at2"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="138" mass="15162" checksum="D21B1DF177C2CB0D" modified="2015-07-22" version="1">MSARDPEIKSELDATLQTRRDLGPEYEEELIEGFLEKVQQRMDGTFDTRLRRQLAEQQMQVARGTQPGASSPEGTFGERFGFAAVSMVLAVPLSAIGVVNEGLAGLLVTWGGIVGVNAVHAAGLFRRRRAEKDKSDWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7I9</accession>
    <name>A0A0F7N7I9_9ACTN</name>
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        <submittedName>
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        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">AA958_19555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
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        <lineage>
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            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomyces</taxon>
        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <end position="36"/>
        </location>
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        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
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        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="339" mass="35254" checksum="D4FAE603DBE344A1" modified="2015-07-22" version="1">MSTDTRTTTAGEGGTPPGDTSAGGSPAPAAGTSPPASSTLRAALLVARVRTATRAGDLDEALRLLRAAEARDARTVGERPEVLDLFARVHAQRGELDAAATYWRRLQARDPADPAARAGLTRITRLTADGPRASLARHRTRTAVVAAVCALAAVATGAVALTGDEEPGHPGGTERAGATEQQIEERVRNELEAAREADRTGEETRREEAAEALAATLRSPGIRPQVRGGSVEVVFTEGVFSEGAELTPEGAARLATLGEHLARLDARIAVHGHAATVPDAPRSGGSVLALWRALIAARELSAASGEPLTAFTTSSADQRDAPYTEDARNRTVTVVITPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7K6</accession>
    <name>A0A0F7N7K6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_23025</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017852.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_23025"/>
    <dbReference type="EnsemblBacteria" id="AKH84595">
        <property type="protein sequence ID" value="AKH84595"/>
        <property type="gene ID" value="AA958_23025"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_23025"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4852"/>
    <dbReference type="OrthoDB" id="1617952at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="50"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH84595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="179" mass="19001" checksum="2B224DB41467E1CE" modified="2015-07-22" version="1">MPVVVAIVVVIGAVAVVNLTFTMAVVRRLREHEERLGRLVGSGAAAPAVLETGDSPDAFATADVDDTPLDEGFLRDVDGALVGFFAPWCKPCKEWMPRFVEAAAAEPGTPALAVLLSDDGWEEMAQQLSPVTRVVAERNDGAVHTAFQARNYPTLYRLDASGAVALNQNSEVVQAPSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7N6</accession>
    <name>A0A0F7N7N6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_15795</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016740.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_15795"/>
    <dbReference type="EnsemblBacteria" id="AKH83428">
        <property type="protein sequence ID" value="AKH83428"/>
        <property type="gene ID" value="AA958_15795"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_15795"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3329"/>
    <dbReference type="OrthoDB" id="990666at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="2"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH83428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="315" mass="33161" checksum="B8F4473A5C6881B0" modified="2015-07-22" version="1">MFSLERLRALDAVAVHGTIARAAESLHVTASGVSQQLAKLERESGQRLLEPYGRSVRLTHAGQVLAAHAARVCAQVAEAEADLADLQDEILGPLRLGGVGSSLRALLPEVLTALTASHPRLTPTVVDGEVVELVPRLVGGELDLLLIESWSSRPIRLPQGLAVRTLVVEDVQLAVPDAHPLAGRERVGLAELGGLAHPTGAAVWASCPVGTEPYEGLTQALREVGLEPEVRYQVTEYATLLALVRGGLCVSLVPEMAQRPCPPGVRFLPVRPAVRRTVQAAWRSRGESPAVRACVAALAEAGQAEAARTEPAAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7N9</accession>
    <name>A0A0F7N7N9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SBP_bac_5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_23130</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017872.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_23130"/>
    <dbReference type="EnsemblBacteria" id="AKH84615">
        <property type="protein sequence ID" value="AKH84615"/>
        <property type="gene ID" value="AA958_23130"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_23130"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4876"/>
    <dbReference type="OrthoDB" id="162819at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519149" description="SBP_bac_5 domain-containing protein" evidence="2">
        <location>
            <begin position="36"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="3">
        <location>
            <begin position="112"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="461"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="465"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH84615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="742" mass="80418" checksum="3B9836DF5F968462" modified="2015-07-22" version="1">MSLHSRRRYTAVLIAAGVTLPLAGCDTSPNDAAGAAHDVTAVSREQLRPGGTVRWAVDEAPETFNVFQADASEATDRVAGAVLPRLFTLDQHGKPTADPDYLESAEIEDRSPKQRVVYRLNPRAVWSDGRPIGAEDFEAQWLALNGEDTAFWTARNAGYDRIESVEAGDEPGEVRVVFDEPYADWEALFSPLYPMSVTKTPEAFNDGSRTGLAEVAGPFTIKDVEGKKKEKKKDGKKKDGKKKDGKKKDEKDKDGKKKDEKKKDEKKKGKRDESDASEPTSVTLVRNPRWWGDRALLDRLVFQELPRGAGREKALDAGRLNIAEVERDEALGAARAERAAKAAVQVTKNDRAQDGKPLDLVTLPKAGPRPYTVHRALEPAYTQLALNGSSGPLADGRVRRAVARAVDRGTLARSVLGPHGLPSKPLGSHLLMPGQPGYSDQSAALGPQDVIAAQKMLAEAGWKGGPRSEEAEAKGAGARDRADGAGSGDDKPAGAVLPTYDVPLSVTQPAQAQYVALARQADLWAAAAKHGKSSKAYKKAVKAARLARTALAERETSVAQPPRQRPFVKNGKPLTLRFVVPQGPGTEQLRSVASRVVRMMDNIGVRTEVVEAGEQGYFKDYIASGEYDMALYSWPGTPYPATDARPIYAKPVPSPDGSLVVEQNYTRVGTDEIDQLFDQAASELDDEVAQELLTRADARIWAAAGSIPLYQRPQLVATTRNLANAGAFGFTTPRYQDIGYRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7Y2</accession>
    <name>A0A0F7N7Y2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Molybdopterin molybdenumtransferase</fullName>
            <ecNumber evidence="7">2.10.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AA958_16475</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 7">Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenylyl-molybdopterin + H(+) + molybdate = AMP + H2O + Mo-molybdopterin</text>
            <dbReference type="Rhea" id="RHEA:35047"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
            <dbReference type="ChEBI" id="CHEBI:62727"/>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.10.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 7">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 7">Belongs to the MoeA family.</text>
    </comment>
    <dbReference type="EC" id="2.10.1.1" evidence="7"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016843.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_16475"/>
    <dbReference type="EnsemblBacteria" id="AKH83538">
        <property type="protein sequence ID" value="AKH83538"/>
        <property type="gene ID" value="AA958_16475"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_16475"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3467"/>
    <dbReference type="OrthoDB" id="651103at2"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061599">
        <property type="term" value="F:molybdopterin molybdotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032324">
        <property type="term" value="P:molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00887">
        <property type="entry name" value="MoeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038987">
        <property type="entry name" value="MoeA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005111">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PTHR10192"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SSF63882"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MoCF_biosynth" evidence="9">
        <location>
            <begin position="391"/>
            <end position="527"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="53"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="564"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="137"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AKH83538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="674" mass="67621" checksum="5D81DAA82F9FA5F3" modified="2015-07-22" version="1">MTSGRRGERRTPGAGAGGGSGNGSDGETGARGDEFADALALANDRRDLAAAYGDAFTLADPPPPEAPAGRVRPGTSREGARTDEFGDALAFTDRNGTEGAAARGAGARADRGARGRGDAFAAPSARTGPGPRAEGRSSGRGARDGSDRDPRERAGGSAPTPPRTGPGRRPDGRAGSDGAGAPAARTGSGRGGDPLDVALGLAGRARREPGDPRGLSWDAARRVAVRSGRRLGAVAVPVAGAYGQVLAEPLRALADLPPFDTSAMDGYAVAGPGPWRLDASGQGILAGHAAHPALPDGHAVRIATGARVPPGATGVLRSEHAELRDDGSLYATGATAAQDVRTGQDIRPRGQECRAGAELLPAGARVTPAVLGLAAAAGHDELRVVRSPRVEILVLGAELLHRGLPREGRIRDALGPMLEPWLRACGAEPFVTRRLGDDAELLYEAVATSTADVVVTTGGTAAGPVDHVHGTLRRLKADLVVDGVAVRPGHPMLLAVLPTGAHVVGLPGNPLAAVSGLLTLAEPLVRVLGGAPVPESPEAVLIADVKGHPTDTRLVPVALEHGAHAPAAHRPARTERPAPTAPAAQIPPPGAQRPARTPAGGAHAAPVRAAASGAPYPAARPLHFTGPAMLRGLAVADALAVVPPGGAPAGTPVRVLRLPWAAAPPAATTPAGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7Y3</accession>
    <name>A0A0F7N7Y3_9ACTN</name>
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        <submittedName>
            <fullName evidence="8">Cell division protein FtsW</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_16350</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_16350"/>
    <dbReference type="EnsemblBacteria" id="AKH83519">
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        <property type="gene ID" value="AA958_16350"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_16350"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3443"/>
    <dbReference type="OrthoDB" id="423699at2"/>
    <dbReference type="Proteomes" id="UP000034283">
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    </dbReference>
    <dbReference type="GO" id="GO:0016021">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001182">
        <property type="entry name" value="FtsW/RodA"/>
    </dbReference>
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        <property type="entry name" value="PTHR30474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01098">
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="203"/>
        </location>
    </feature>
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            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="291"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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        <location>
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            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="423"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="449"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AKH83519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="469" mass="49473" checksum="D7980AEF3B8576E8" modified="2015-07-22" version="1">MSSSHTSTISSVAAPSRRNTELAMLVFAVLIPVFAYVNVGLAKEDTVPAGVLGYAAGLGCLAAVAHLVVRKFAPYSDPLLLPIATLLNGLGLVLIWRLDQEPSLTTPALGGPMAPGQLMWSAVGVGLFVVVLLFLKDHRVLQRYTYISMAAALILLIMPMVPGLGANVNGARIWIRIPGLGSLQPGEFAKIVIAVFFAGYLMVKRDALALASRRFMGLYLPRGRDLGPILVIWGLSLMILVFETDLGTSLLFFGLFVIMLYVATERTSWIVFGLLLSALGAVSVASFNSHIGDRVDNWLNPLARSPVNDGVTETAQAMYSFGSGGLFGSGLGQGFSRLIGGIATKSDYILATVGEELGLTGLMAIVVLYGLLIERGMRTALAARDPFGKLLAVGLSGAFALQCFVVAGGVTALIPLTGMTMPFLAQGGSSVIANWALIAILLRISDTARRPAPAPAPSPDAEMTQVVRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N829</accession>
    <name>A0A0F7N829_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_23890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017997.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_23890"/>
    <dbReference type="EnsemblBacteria" id="AKH84745">
        <property type="protein sequence ID" value="AKH84745"/>
        <property type="gene ID" value="AA958_23890"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_23890"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5034"/>
    <dbReference type="OrthoDB" id="2052863at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046086">
        <property type="entry name" value="DUF6104"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19599">
        <property type="entry name" value="DUF6104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH84745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="59" mass="7206" checksum="CC8E27743DA358BA" modified="2015-07-22" version="1">MYFTDRGIEELEKRRGEEEVTFEWLAEQLRTFVDLNPEFEIPVERLATWLARLDDEDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N833</accession>
    <name>A0A0F7N833_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_12795</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016291.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_12795"/>
    <dbReference type="EnsemblBacteria" id="AKH82957">
        <property type="protein sequence ID" value="AKH82957"/>
        <property type="gene ID" value="AA958_12795"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_12795"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2688"/>
    <dbReference type="OrthoDB" id="129011at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013105">
        <property type="entry name" value="TPR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07719">
        <property type="entry name" value="TPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="568"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="602"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="636"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="704"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="738"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="772"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="806"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="840"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="942"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH82957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="1124" mass="122993" checksum="E8182AB87DBCBB32" modified="2015-07-22" version="1">MQDLIRDRRRSGFVGRQREITAYRDNFRCPPEDPAHRFLFHFHGVAGVGKTSLLRRLLQLAGEHGALTAQVDESAASVPEAMEAISTQLARQGHPLKGFDRLLQRYRQRRHEADSVVATLDGAPGQPGTGAPGVPHPAGPVDAAGPVPAAQAPPAASPAAGIAAQAGLAGLGLVPGLGAVAGAMDPQQVAQSLDRWRAALSTRLRSHDDVQLVLSPLQALTPAFLEDLRGVATAVPWLALFFDTYERTGPVLDAWLCDVMTSDRYGALPANVVVTRAGQQRLDPARWPAGDFAAELELELFTEEEARALIAARGIADARVVDEILHLSGRLPVLTSMLAETPPVRPGGADPSGTAVERFLKWVADPVQKAAAQAAALPPSLDEDVFRVAVAPAAAGLYGWLRALPFVSDEAGRVQYHGVVRSAMLRVQRAQSPQRWREQHRALAAAHAGWCAELEASLPAGNDVREERWLDERWFGHRRYETYHLLCADPQGALPRARRDALQAADVGPAETRRWAQTMEQAGTDADSEPVRDWGRRLLAVLGEGPRGVVEVCTFLLREAELTEPERVLAYTLRGRERRNADELDASVADFDRALALDPAFTRAYAGRGQAYVLLDRYAEADADFTRCVEADSDRAWSLTHRGRARLYLERYDDAKADLDQAVELDPSPMSWAMRGEVRRVAGDPERAIPDFDRAVEAAEGDYAYAYASRAQCHAALGRPEEALADLDRALAVDPQWEWCWVERGRLHQDAERFGAAAADYTRALELSPDYAWAYANRGESYRRLNRLDEALTDVDRALELKPEWSWCWGERGEVHRLAGRIEEALACFDRAVELEHDYAWAIAGRGQCLAAQRQVDAAIAEFTRALEIDPQLTWVLETRGAFHRMADRFDDSLADYARALEIDATRRWARIGRARTLGHLGRTAEAYAEVEAVLAEWPDHADGLSLKGRLLSLEGRHEEALAALDAALAADPDDHSLHGDKAETLMELGRYEEARPHVAAALAAGPEDGYARFDDLLLARLTGASPTAGRWAEAEAAMLADGVTDADRVQARLMCRAAGGDWAAADAALAELASAQTYWLLLKDVRALFSMLAATPATAAADLPRIEGYLRTTDDLLRELPGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N893</accession>
    <name>A0A0F7N893_9ACTN</name>
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        <recommendedName>
            <fullName evidence="3">PALP domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="4" type="ORF">AA958_17295</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP011492">
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    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_17295"/>
    <dbReference type="EnsemblBacteria" id="AKH83673">
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        <property type="gene ID" value="AA958_17295"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_17295"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3637"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="P:alpha-amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
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    </dbReference>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="19"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH83673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="318" mass="33148" checksum="56A4BDFFBA01E3D9" modified="2015-07-22" version="1">MVKPLKVENIEEAASLIDPVFRDSPYVEDAALARRVGRDLALKLETLNPIRSFKGRGADYFMHELAEGQRVVCASAGNFGQAVAYAGRARGIAVTVYCARNANPVKVARMRDLGAEVVLAGADFDAAKDAARAYADGAADRLFVEDGEEPRISEGAGTIAVELAPFPGTLLVPVGNGALIGGIACWAKARAPRTRIVGVCAAGAPAMAESWRRNAPVSTPEARTIADGVAVRVPVPAAVDRMRGLVDDVVLVDDDQIREALRAVRDTVGLILEPAAALGVAAALHHRFAPGALATVVTGSNFSPELLAELAELPAGTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N897</accession>
    <name>A0A0F7N897_9ACTN</name>
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        <submittedName>
            <fullName evidence="8">Type II secretion system protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="8" type="ORF">AA958_13030</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP011492">
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_13030"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2742"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="225"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="7">
        <location>
            <begin position="115"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH82997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="306" mass="32602" checksum="F397303D5CF25E19" modified="2015-07-22" version="1">MNGSIFSATMGYGLLAGAVIGGGIALLIVALRGLPAKPEHEKEQQGERAAELVRFASQRATLAAVAGLLVLLLTRWPVAGLATGVLVAFWDKLFGGAAAERTAMKRVEALAQWTESLRDTIAGAVGLEQAIPASARAAAPALRPHLDAMVDRLRSRTPLPDALQHLADDLDDASADLIIAALILNARLRGPGLREVLGALAKSAREEVDMRQRVMAQRASTRRSVQIVVSVSVAFVLGLSVFNRGFVEPYGSPVGQAVLACVCGLFAAGFWWLRKLSTIETPERFLAGAKQQPQQVAFVRPREEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8J9</accession>
    <name>A0A0F7N8J9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_17865</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_17865"/>
    <dbReference type="EnsemblBacteria" id="AKH83764">
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        <property type="gene ID" value="AA958_17865"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_17865"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3763"/>
    <dbReference type="OrthoDB" id="1708231at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH83764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="290" mass="28283" checksum="44654A5FE2C09068" modified="2015-07-22" version="1">MGSFRRPVGPLPSAIYWRRRAVLLGLLAVLAIFAILVINLGGDSENAANEGKNPAESITPGPTDDSSVIDNPPGGRDEDGGGSGDSEGSGGSGDEDGGGSGDSEGSGGSDGSGDGGGSGDGEDGGSAGGGSGAGGAGSAGGGFDAGSDGVPAGSSMAACAAGDVELTLRSQERSYAPGERPVFEVTAVNSGDRDCKLDFSPTSTVLTISAAGGGASRWWASDDCPWTTDPILLAVPAGSGVSRTYEWDMRASEPRCATPKAGTAGAGSYEAEVSADGLATARAPFVLEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8S0</accession>
    <name>A0A0F7N8S0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4007 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_18740</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017195.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_18740"/>
    <dbReference type="EnsemblBacteria" id="AKH83898">
        <property type="protein sequence ID" value="AKH83898"/>
        <property type="gene ID" value="AA958_18740"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_18740"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3930"/>
    <dbReference type="OrthoDB" id="1476027at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025248">
        <property type="entry name" value="DUF4007"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13182">
        <property type="entry name" value="DUF4007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4007" evidence="2">
        <location>
            <begin position="14"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="344"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH83898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="370" mass="41838" checksum="D993AC76A8F6354D" modified="2015-07-22" version="1">MSDSRLGEAALFSFARHETFAPRFGWLHKAYMQVKRDQGAFLAVDAPVRFGVGKNMVYSMRYWARAFKLTREHSPTKGTQAKFSYPTWEARWLLDEDGADPYLEENGSLWLLHWWLVSSRPGAKSHAPAWYTAFHLAPFSRFTVADMTQVVTRHVNFSYDKSPEEASIVKDIECLTKMYARSAPEKAGSPGSYEDLLACPFRDLDLLTFVGTRGNAEWQFTSGHRTSLPARILAYACLDYAAKFSRQANSISVARLANEPGSPGRAFRVRENEIVIALQKVTADHPQLDLTEALGQRSLAFMADPFDLAWEVLDEQYDFVTRRPHFPTREEWAAEFPKLAKAEQKELATKATDATDPDATTDTLFAKETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8V6</accession>
    <name>A0A0F7N8V6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Beta_helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_25235</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018216.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_25235"/>
    <dbReference type="EnsemblBacteria" id="AKH84965">
        <property type="protein sequence ID" value="AKH84965"/>
        <property type="gene ID" value="AA958_25235"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_25235"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5318"/>
    <dbReference type="OrthoDB" id="311309at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039448">
        <property type="entry name" value="Beta_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13229">
        <property type="entry name" value="Beta_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519369" description="Beta_helix domain-containing protein" evidence="3">
        <location>
            <begin position="30"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="532"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="558"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="585"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="616"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="648"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="domain" description="Beta_helix" evidence="4">
        <location>
            <begin position="190"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="463"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="672"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="673"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="716"/>
            <end position="730"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH84965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="730" mass="78413" checksum="15232508CCAF7BD0" modified="2015-07-22" version="1">MSWTRKVRTALLPLVALGALLVTAAPAAAHEERPVEFPDGTGSVPSYRDEEPDLLVCKPGRADFEARIADFPAALRERNLRLYERCRDRGYEHLQEAVDAVDAPGMTIAILPGVYLEEPSRPKPTGSCARLKAPRSDFGYQILSYAQQERCPHNQNLVAIMGKRDLQIEGTGADRGDVVIDGQYRKLNVIRADSADGVYFRNFTAQRSTFNSLYVLAADGFVIDDVLTRWNDEYGFLTFASDHGLYRDCESYGNGDSGIYPGSASDINDGRGYDVPRYAIEITGCRSHHNMVGYSGTAGDSVWVHDNEFDHNMGGASMDSAFPGHPGLPQNHARFERNLIHDNNQNYYPYVADGTCAEPPAERGYEQGVVCPQISMPPGTGIITAGGNWNIYRDNWIYGHQRAAFYLNAVPAFIRGEGSPGKQLDTSHHNRYAANHLGVDRAGNERPNKTDVWWDGQGEGNCWQGDAGASNPRTLPECGSRPGDVSGGSDRIVGEPVKLAQLLVCAEYDVRARKLPAGCDWYGARGIERIEVQIALAVAVVLGLVGGVLWWRLLRRDAVAGGAAVAGAAGLALDVVGAASSYAHTWVPVVALVLLGAWWTATGLRLRARLPGGRPGFTGATVAMGVLTLLDAFDKSVLLIPWIPLSPAWLRTLLGLVWVIWAVIAVARRVPAPDPAPDREADPAADPAAEKAAEPAGPGSEHATPAADPGSGRPAAGPRPAGPAPEAGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N969</accession>
    <name>A0A0F7N969_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Signal recognition particle receptor FtsY</fullName>
            <shortName evidence="5">SRP receptor</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ftsY</name>
        <name evidence="9" type="ORF">AA958_25875</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the GTP-binding SRP family. FtsY subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018323.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_25875"/>
    <dbReference type="EnsemblBacteria" id="AKH85080">
        <property type="protein sequence ID" value="AKH85080"/>
        <property type="gene ID" value="AA958_25875"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_25875"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5449"/>
    <dbReference type="OrthoDB" id="656414at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031226">
        <property type="term" value="C:intrinsic component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00920">
        <property type="entry name" value="FtsY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004390">
        <property type="entry name" value="SR_rcpt_FtsY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036225">
        <property type="entry name" value="SRP/SRP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43134:SF7">
        <property type="entry name" value="PTHR43134:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47364">
        <property type="entry name" value="SSF47364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00064">
        <property type="entry name" value="ftsY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="9" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 5" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="SRP54" evidence="8">
        <location>
            <begin position="375"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="26"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="210"/>
            <end position="217"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="292"/>
            <end position="296"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="354"/>
            <end position="357"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH85080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="403" mass="41846" checksum="6998434E3FAE052E" modified="2015-07-22" version="1">MDIILIVIAIAVVAVLVAGGLVVGSRRRKQVPPPPSPGTTTPAEPQVGEEAGEPGDEQRRTIEEVGLPGEAAATGTVVAEPPAPAPELEVPAPSAGRLVRLRARLARSQNSLGKGLLGLLSREHLDEDTWEEIEDTLLTADVGVQPTQELVERLRERVRVLGTRTPEELRALLREELLALVGTEADRSLDTAESVGPEGGEVPGVVLVVGVNGTGKTTTTGKLARVLVADGKSVVLGAADTFRAAAADQLQTWGERVGARTVRGPEGGDPASVAYDAVKEAIDEGADVALIDTAGRLHTKTGLMDELGKVKRVVEKHGPVGEVLLVLDATTGQNGLVQARVFAEVVDITGLVLTKLDGTAKGGIVIAVQRELGVPVKLVGLGEGADDLAPFEPEAFVDALIGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N973</accession>
    <name>A0A0F7N973_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Signal recognition particle protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Fifty-four homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ffh</name>
        <name evidence="12" type="ORF">AA958_25905</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="7">The SRP-RNC complex is targeted to the cytoplasmic membrane.</text>
    </comment>
    <comment type="domain">
        <text evidence="7">Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the GTP-binding SRP family. SRP54 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018327.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_25905"/>
    <dbReference type="EnsemblBacteria" id="AKH85085">
        <property type="protein sequence ID" value="AKH85085"/>
        <property type="gene ID" value="AA958_25905"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_25905"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5455"/>
    <dbReference type="OrthoDB" id="656414at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048500">
        <property type="term" value="C:signal recognition particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00306">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036891">
        <property type="entry name" value="Signal_recog_part_SRP54_M_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004125">
        <property type="entry name" value="Signal_recog_particle_SRP54_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004780">
        <property type="entry name" value="SRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022941">
        <property type="entry name" value="SRP54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564">
        <property type="entry name" value="PTHR11564"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564:SF7">
        <property type="entry name" value="PTHR11564:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02978">
        <property type="entry name" value="SRP_SPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47446">
        <property type="entry name" value="SSF47446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00959">
        <property type="entry name" value="ffh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0733">Signal recognition particle</keyword>
    <feature type="domain" description="SRP54_N" evidence="11">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="9">
        <location>
            <begin position="99"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="SRP54" evidence="10">
        <location>
            <begin position="100"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="432"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="456"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="107"/>
            <end position="114"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="192"/>
            <end position="196"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="250"/>
            <end position="253"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AKH85085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="515" mass="55129" checksum="D6E854B415F76490" modified="2015-07-22" version="1">MFDTLSDRLAATFKTLRGKGRLSEADIDATAREIRVALLEADVALPVVRAFIKQVKERALGAEVSQALNPAQQVIKIVNEELVGILGGETRRLRFAKTPPTVIMLAGLQGAGKTTLAGKLGKWLAGQGHTPLLVAADLQRPNAVNQLQVVGERASVAVYAPEPGNGVGDPVRVAKDSITHARDKQYDVVIVDTAGRLGVDAEMMQQAADIRDAVGPDEILFVVDAMIGQDAVSTAESFRDGVGFDGVVLSKLDGDARGGAALSIAQVTGKQIMFASNGEKLDDFDAFHPDRMASRILGMGDMLSLIEKAEQTFSQQEAEKMAAKLAKGPKEFTLDDFLAQMEQVRKMGSISKLLGMMPGMGQMKEQINNLDERDVDRTAAIIKSMTPGERHDPMIINGSRRARIARGSGVEVSAVKNLVERFFEARKMMSKMAQGGGMPGMPGMPGMPGAGGGGKRKGKQQKKAKGRQRSGNPMKRKADEQAAAERRAASGSPFGGGAEQPPQDFELPEEFKKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N976</accession>
    <name>A0A0F7N976_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_14895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="444103.AA958_14895"/>
    <dbReference type="EnsemblBacteria" id="AKH83292">
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    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_14895"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3139"/>
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    </dbReference>
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        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="13"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="135" mass="14473" checksum="28885DCFA72020E4" modified="2015-07-22" version="1">MTAESNKTLVGQALAALVETGSTDGLAPLLHDDFVHHRPDATTSDKTAWLAAVRAALIPLAGMRVEIHHLLADGDHVVMHSRRWLPGGGPEITVADVWRIEDGLIAEAWEIIEPAAQAAAHLSWWETPAGEPGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9E9</accession>
    <name>A0A0F7N9E9_9ACTN</name>
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        <submittedName>
            <fullName evidence="2">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_23390</name>
    </gene>
    <organism evidence="2 3">
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        <lineage>
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            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84661.1"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_23390"/>
    <dbReference type="EnsemblBacteria" id="AKH84661">
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        <property type="gene ID" value="AA958_23390"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_23390"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4931"/>
    <dbReference type="OrthoDB" id="1119700at2"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0016787">
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="24"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="297" mass="31763" checksum="4C8BD88204F38563" modified="2015-07-22" version="1">MTLPGLTLAVRGHPPARPGLPPAVYVHGLGGSALNWAGLGPLLAARVDGDAVDLPGFGDSPPPDDGDYSLSGHARAVIRYLDAADRGPVHLFGNSLGGTIVTRVAALRPDLVRTLTLVSPALPELPPQRTAMPTALLAVPGVTALFARLTRDWTAERRTRAVLGLCYGDPGRVSPEGFAEHAREYARRMRLPYHWDALERSARGVVGAYTLGGQHSLWRLAERVLAPTLLIYGGRDQLVSFRMARRAKAAFRNSRLLALPAAGHVAMMEYPEVVARAFTEMLDEYETGIADASPGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-10-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9G9</accession>
    <name>A0A0F7N9G9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_20500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH84173">
        <property type="protein sequence ID" value="AKH84173"/>
        <property type="gene ID" value="AA958_20500"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_20500"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4320"/>
    <dbReference type="OrthoDB" id="1217672at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="95" mass="10743" checksum="BD1C43479DBEF1F8" modified="2015-07-22" version="1">MLEALARQHDLWANINATPVEDRLGADLIYYHEATQSFVLVQVKRLPSAAGDRWMYVDQRLLGQLDRLDRVAAMSRTPQVPDQCGRPCSARPDGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-08-12" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9L1</accession>
    <name>A0A0F7N9L1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DGPF domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_23770</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the YciI family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017978.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH84726">
        <property type="protein sequence ID" value="AKH84726"/>
        <property type="gene ID" value="AA958_23770"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_23770"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5009"/>
    <dbReference type="OrthoDB" id="2051456at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005545">
        <property type="entry name" value="YCII"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03795">
        <property type="entry name" value="YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YCII" evidence="2">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH84726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="137" mass="14895" checksum="9FF426D5A0E3A2E8" modified="2015-07-22" version="1">MKYLVMIYGSQADYDAMNGKGSEGHPAWTEKDLQAMFEHMGSINNDLAESGELVDGQGLTAPKQAILVTRGPDGAAVVSDGPFGETKEVLAGYWVLDCAGDERVTEIAKRVHECPLPEGFPSSDIVIRRIQEEPQDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9V4</accession>
    <name>A0A0F7N9V4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">50S ribosomal protein L23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rplW</name>
        <name evidence="6" type="ORF">AA958_21185</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL23 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017565.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_21185"/>
    <dbReference type="EnsemblBacteria" id="AKH84288">
        <property type="protein sequence ID" value="AKH84288"/>
        <property type="gene ID" value="AA958_21185"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_21185"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4462"/>
    <dbReference type="OrthoDB" id="1978865at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01369_B">
        <property type="entry name" value="Ribosomal_L23_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_L23/L15e_core_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013025">
        <property type="entry name" value="Ribosomal_L25/23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11620">
        <property type="entry name" value="PTHR11620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00276">
        <property type="entry name" value="Ribosomal_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="SSF54189"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH84288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="122" mass="13595" checksum="5989D770338E73B1" modified="2015-07-22" version="1">MVDMDKTGAEAADETAAEFTVTSKTYDDPRDVLLKPVVSEKSYALLDENKYTFIVDPRANKTQIRQAVEKVFQVKVIGVNTINRQGKRKRTRTGYGKRADTKRAIVTVAEGERIDIFGGPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NA39</accession>
    <name>A0A0F7NA39_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_27785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018639.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_27785"/>
    <dbReference type="EnsemblBacteria" id="AKH85405">
        <property type="protein sequence ID" value="AKH85405"/>
        <property type="gene ID" value="AA958_27785"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_27785"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5857"/>
    <dbReference type="OrthoDB" id="1746871at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022386">
        <property type="entry name" value="Chitin_NgcE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03851">
        <property type="entry name" value="chitin_NgcE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519232" evidence="1">
        <location>
            <begin position="35"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="472" mass="50828" checksum="08369AF4B1F7F254" modified="2015-07-22" version="1">MGSTSEVGRRDLVKQAMALGLISVPTIGALTACASGGDDDNGGGAKGEKTEKNPLGVDKNAPLELLIFDGGFGTQYVEDDAAAYQKKYAKVTTGSTVKIQSKVQGRMAAGDPPDVINNSGDEAMDVPALIGQGQLADMTPLLNAPSIDAPSKTVAETLRPGTVEMGQYGDEKCYRMNIAYSVFGIWYSQKMLDDHGWEYPKTWDDMLAVCAEAKKAGIAGWTYTGVYPQYLGFSMLPMIGKVGGAEVLDAIDNFEPNAWKHDSVKSVLEAHYELYAKGYVLKGSGGWKHTESQTKWTEGKALFIPNGSWVENEAKDTTPDDFQMTVSPSPNLDSSDAMPFETIWAQAGEPYIVPAKAKNVNGGLEFLRHMLTKESAAGFTKLVSSLASVQGSEEGLELGTGLTSAIGLMDAAGENFLNPRFPDWYPTTWREHVVFVLGDMMKGDASPGEAVNKIQQIADDAAKDDSIKKYKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-12-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NA80</accession>
    <name>A0A0F7NA80_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AA958_28095</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018689.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH85455">
        <property type="protein sequence ID" value="AKH85455"/>
        <property type="gene ID" value="AA958_28095"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_28095"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5921"/>
    <dbReference type="OrthoDB" id="149255at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004869">
        <property type="entry name" value="MMPL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03176">
        <property type="entry name" value="MMPL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="204"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="252"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="291"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="320"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="391"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="546"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="579"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="613"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="659"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="693"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="8">
        <location>
            <begin position="217"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="738"/>
            <end position="764"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH85455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="764" mass="80282" checksum="DA35425A5210E534" modified="2015-07-22" version="1">MGAPRAPRHTKRRQGVAAAVGGWSVTHRWAAVGIWVLFVVLATVAGSAAGRAEVSDSEEVPGETGRSAKILEDAGVDEPVGESVLVQSRQGGPKASASEFRTAVEDVVRAVEGTGEVTDVVSPYESDTISADGRSALVQFRMKGDPETAADRVEPVTDAVAEVQDAHGPRGLLIEEIGGASMEKTFDDAFGEDFKKAEYSAVPIAFGILLIVFGAFVAALLPMVLAITAIVATMGLMGVVSHVQPMSDVADSVMLLVGLAVGVDYCLFYLRREREERARGRDARTALEIAAATSGRAVLVSGITVIVAMCGMLFTGLADFAAMGVASLMVVAVAMVGSVTVLPAMLSLLGERVEKGRVPFLARLKRGRTNAGGESRVWRAVLTRVLRRPKAAVIVATGALAAIALPAVGMNTANLTLDQEFGDSLPIVQTYDRINEAFPGGSDPAEVVVRADDINAPEVREAIVDFEEQALDTGASKGPIDIQVYDEKNVAIIEVPLVGGSDQDKAEKSLALLRDEIRPVTLEAVDGVEAPVGGQVAGSKDFNDQLVGAVVPVFLFVVAFAFLLMLMAFRSLTIAVTSILLNLLSVGAAYGVLTMVFQHGWGAGLVGAEGVGAIVAWLPLFLFVILFGLSMDYHVFVVSRIKEARAQGRSTADAISHGVITTAGVVTSAAVIMVAVFSIFGTLSMQSMKQMGVGLATAVLIDATIIRGVLLPAVMALLGERNWYFPKALRRLPDLEHAEPQPVPMGSVPPPVPADSPLAEGSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NA94</accession>
    <name>A0A0F7NA94_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_25265</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018222.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_25265"/>
    <dbReference type="EnsemblBacteria" id="AKH84971">
        <property type="protein sequence ID" value="AKH84971"/>
        <property type="gene ID" value="AA958_25265"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_25265"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5325"/>
    <dbReference type="OrthoDB" id="1832160at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HATPase_c" evidence="2">
        <location>
            <begin position="71"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH84971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="191" mass="21121" checksum="8BF4B652521B316E" modified="2015-07-22" version="1">MAGLEDIQQLHRDEPAHPEAPAGRRSRRKLLRPLPSPAYRRFPAAAPAGGAAGPDPMERWGNPAVGEVRLPSRPESAGTARRLAEAVVVRHWGMSPGFAEHAVLLVSELVGNAVRHTGARTFGLRMSRPRGRIRIEVRDPSRALPCLMPVRDMDTSGRGLFLIDQVADRWGVDLLPRGKCTWVELREPERD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAD9</accession>
    <name>A0A0F7NAD9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptide ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_22265</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017729.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_22265"/>
    <dbReference type="EnsemblBacteria" id="AKH84468">
        <property type="protein sequence ID" value="AKH84468"/>
        <property type="gene ID" value="AA958_22265"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_22265"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4689"/>
    <dbReference type="OrthoDB" id="1181903at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH84468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="227" mass="24043" checksum="59DBC9B843CABBBC" modified="2015-07-22" version="1">MYQLTGVTKRYQRGKEAIDALAGVDLTIADGDQLVVRGPTGGGKSTLLQLLGGLDRATSGTVSLDGTDLGGLSEAALTRVRAATIGFVFQSFNLIPTLSAQENVETALVPLGVKATERAKRAAEALESVGLAERLTHLPGELSGGQQQRVAIARALVKQPKVLLADEPTGNLDEDTRDDIVALLEGLWKELGLTYVLVTHDSAIARRAPRLAVIKKGRLKVTEREAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAH5</accession>
    <name>A0A0F7NAH5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nucleoside triphosphate pyrophosphatase</fullName>
            <ecNumber evidence="2">3.6.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Nucleotide pyrophosphatase</fullName>
            <shortName evidence="2">Nucleotide PPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_22215</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Nucleoside triphosphate pyrophosphatase. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + H2O = a 2'-deoxyribonucleoside 5'-phosphate + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:44644"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:65317"/>
            <dbReference type="EC" id="3.6.1.9"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-phosphate + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23996"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="EC" id="3.6.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Maf family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.9" evidence="2"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017720.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_22215"/>
    <dbReference type="EnsemblBacteria" id="AKH84459">
        <property type="protein sequence ID" value="AKH84459"/>
        <property type="gene ID" value="AA958_22215"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_22215"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4678"/>
    <dbReference type="OrthoDB" id="1469203at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036218">
        <property type="term" value="F:dTTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035529">
        <property type="term" value="F:NADH pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00555">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00528">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003697">
        <property type="entry name" value="Maf-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43213">
        <property type="entry name" value="PTHR43213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02545">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006305">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="SSF52972"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00172">
        <property type="entry name" value="maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH84459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="202" mass="20583" checksum="CF0DC5B9FD0BF937" modified="2015-07-22" version="1">MTHHPARTLVLASQSPARLALLRQAGLAPEVVVSGVDEDAVTAATPAELALVLAEAKAGAVAARPEAAGALVVGCDSVLELDGRALGKPVDAEDATARWKAMRGRSGVLQTGHCVIDTASGRRASATAGTVVRFGEPSDAEIAAYVATGEPLYVAGAFTIDGRSSAFIDGIDGDHGNVVGISLPLLRRLLAEVGVQITDLWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAJ2</accession>
    <name>A0A0F7NAJ2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Proline--tRNA ligase</fullName>
            <ecNumber evidence="7">6.1.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Prolyl-tRNA synthetase</fullName>
            <shortName evidence="7">ProRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">proS</name>
        <name evidence="9" type="ORF">AA958_25910</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro)</text>
            <dbReference type="Rhea" id="RHEA:14305"/>
            <dbReference type="Rhea" id="RHEA-COMP:9700"/>
            <dbReference type="Rhea" id="RHEA-COMP:9702"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78532"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.15"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.15" evidence="7"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018328.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_25910"/>
    <dbReference type="EnsemblBacteria" id="AKH85086">
        <property type="protein sequence ID" value="AKH85086"/>
        <property type="gene ID" value="AA958_25910"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_25910"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5456"/>
    <dbReference type="OrthoDB" id="665824at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004827">
        <property type="term" value="F:proline-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006433">
        <property type="term" value="P:prolyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00778">
        <property type="entry name" value="ProRS_core_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01571">
        <property type="entry name" value="Pro_tRNA_synth_type3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002316">
        <property type="entry name" value="Pro-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004499">
        <property type="entry name" value="Pro-tRNA-ligase_IIa_arc-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016061">
        <property type="entry name" value="Pro-tRNA_ligase_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033721">
        <property type="entry name" value="ProRS_core_arch_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43382">
        <property type="entry name" value="PTHR43382"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01046">
        <property type="entry name" value="TRNASYNTHPRO"/>
    </dbReference>
    <dbReference type="SMART" id="SM00946">
        <property type="entry name" value="ProRS-C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00408">
        <property type="entry name" value="proS_fam_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="8">
        <location>
            <begin position="34"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH85086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="475" mass="52152" checksum="55A825B868F98843" modified="2015-07-22" version="1">MAKAPVLTPQADDFPRWYQDVITKAELADNGPVRGTMVIRPYGYGLWERTQREMDDRIKAAGAQNAYFPLFIPESYLAREADHVEGFAPELAVVTHGGGKELEEPVVVRPTSETIVNDYFAKWVQSYRDLPLLINQWANVVRWELRPRMFLRTTEFLWQEGHTAHATYEEARDYAARIQRDVYADFMVNVLAIDVLPGRKTAAERFAGALNTLTLEAMMRDGKALQMGTSHELGQNFAKAFGTRYLTADGAREHVWQTSWGSTTRMVGGMIMVHGDDDGLRVPPRLASVQAVVLAVKGDEAVLAKVREAGDRLAAAGVRVRVDDRVDVPFGRRAVDWELKGVPVRVEIGPRDLAAGTATLVRRVPGTKEPVALDALLDDGAGMLPKILEDDQERLLAESRRMREEGTTDVRTVAEAAEAAAAGGWARIPWADLGPAGEARLAEQAVSVRCLIAADGSVPGADDEPGTLAVVARAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAN7</accession>
    <name>A0A0F7NAN7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BACON domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_17855</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017064.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_17855"/>
    <dbReference type="EnsemblBacteria" id="AKH83762">
        <property type="protein sequence ID" value="AKH83762"/>
        <property type="gene ID" value="AA958_17855"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_17855"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3761"/>
    <dbReference type="OrthoDB" id="1388765at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd14948">
        <property type="entry name" value="BACON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024361">
        <property type="entry name" value="BACON"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19190">
        <property type="entry name" value="BACON_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BACON" evidence="2">
        <location>
            <begin position="446"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="377"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="527"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="541"/>
            <end position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH83762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="623" mass="64852" checksum="6BCDE99E5A557F27" modified="2015-07-22" version="1">MTSSPDPEPARQPPPLRPPEQYEPYLDGLFTYCMSVLCDHDDAVAALGDVLAIAERQLRRRPATPAEWRPWLYSLARWACLRRLDQKPGQRAAQRMLPRPGHRPAQRRPAPAAEEKRSASAAEAGAAPAPGAASAAGAEAAPEPGSAAASAAAPEAAGESASAAAARLRRRELAALAWPEAAGTTPEQREALELAVRHRLPSEEVATVLGQHPDAARVLLSTAAAEVERTRAALAVVDQHGCPAIARLAGDSRLFLSAALSRELVRHVDDCAECRRAAERAGAGWAWPGTLRAARPDGPLPVLEAPRAAAYAAMRRAQRTRFVHAPRFDRRGYPRDPRHRAARRGRLRSRAVTSTVVATVIAAPVLALWAANRGAPAAGEAESGWPPPSADAEEPESLDGRPVEKAGSAHDDSVPASRDGNHPDVSVEVHDRGGPTPGGPGVGPGRLTVEAWPAGETTYLRLRASGGTPVDWRVGTDAGWLRFSATYGTLRPGQATTVAVTVAEVSEPRTGWQTRVYVSPGGAAILITGAGSGRTSPGGAPAPTHPEPPPHSPPGTPRPSDPAPSPSDPDPGPSDPDPSPSDPDPSPSDPDPSPSDPDPTPTASEPDPSPPDSSPAQAPSGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAT1</accession>
    <name>A0A0F7NAT1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_18150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017112.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_18150"/>
    <dbReference type="EnsemblBacteria" id="AKH83812">
        <property type="protein sequence ID" value="AKH83812"/>
        <property type="gene ID" value="AA958_18150"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_18150"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3816"/>
    <dbReference type="OrthoDB" id="1499826at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="445" mass="47093" checksum="280C9386AAB0588F" modified="2015-07-22" version="1">MADKDYPALGFDPAPGDAHSTKYLARSIGRLAGELGTTAKELERLDQGVWKGKAANAFSDHVADKVTPDIKRAHTSFEKAATALRRWSEKMDRFQDEARALEREARRKQEALGDAQRLLDAGKAAPFPGASDDEKASDAQKKQQDKREKAAEEAGDALDEVRRRAEELKDRYFTEAWSISRELDSAGDIAPDEPGLFDRIASGVSDVLGDTLDWVQDHADLIKAIGDVLSYVTAALAVLAIVTAPFGIGAAFATAALITGGLTLATHGIAKAAGADVSWTTIGLDVLGVLPGIGAFSKGAKVADATAAQTRAAQLGANYAGDAVKVRNFVSFGDEAGRVIGGVQRSPFGKNVALWGRKEVGIVTSRAGGLQNRMLGIAEAATWKGQWLGTRTLSYGPDRLAVDPLSVGGRMLDSGLKMSPKLVTIPQHLGVDVNIGDRFEAAFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAV1</accession>
    <name>A0A0F7NAV1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_23265</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017894.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_23265"/>
    <dbReference type="EnsemblBacteria" id="AKH84638">
        <property type="protein sequence ID" value="AKH84638"/>
        <property type="gene ID" value="AA958_23265"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_23265"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4904"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019933">
        <property type="entry name" value="DivIVA_domain"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03544">
        <property type="entry name" value="DivI1A_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519916" evidence="2">
        <location>
            <begin position="22"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH84638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="202" mass="20294" checksum="3C810C6D16C76A6C" modified="2015-07-22" version="1">MFWFMLIAMVVVVAAVTLVLAGNGEEELTEPQPDRLHDPLPPDRPLGRADIDALRLPVALRGYRMDDVDDALDRVAAELAERDARIAELEAALAGAHAAAYRGGGTGGQGYEDAPPGPGFGGAGGVADPGGQSNGGTDLGTWDLGGRGNGGTDLGARDPGGQDPGGRGNGGTDLAGRDAGGREAHGRGPGGADPREGLDGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAW9</accession>
    <name>A0A0F7NAW9_9ACTN</name>
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        <submittedName>
            <fullName evidence="1">Sucrase ferredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_26835</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018488.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_26835"/>
    <dbReference type="EnsemblBacteria" id="AKH85251">
        <property type="protein sequence ID" value="AKH85251"/>
        <property type="gene ID" value="AA958_26835"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_26835"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5645"/>
    <dbReference type="OrthoDB" id="1095432at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd03062">
        <property type="entry name" value="TRX_Fd_Sucrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009737">
        <property type="entry name" value="Aim32/Apd1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010350">
        <property type="entry name" value="Aim32/Apd1-like_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030108">
        <property type="entry name" value="Apd1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31902">
        <property type="entry name" value="PTHR31902"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31902:SF10">
        <property type="entry name" value="PTHR31902:SF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06999">
        <property type="entry name" value="Suc_Fer-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF035042">
        <property type="entry name" value="UCP035042_thirdx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH85251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="324" mass="33695" checksum="8CEFFCC0F3201A6D" modified="2015-07-22" version="1">MSTCATASGELAEPLAGTAAVAATWLLVEQTGPWGKEALTQSHLDPGIGRALEEHAEGTGVRVALIRRPGRHADVRRPASRRVLAAHTAPGGTWIRATDVRDPADLVGLDLAALGRGEHAGFDAALGAGAYRGDPSPRPGRPGQTPGSLPLVFVCTNGRRDRCCALLGRRLAADLHAAGSTETWEITHIGGHRFSPTLLLLPHGYAYGRMTPHAVKEVVESLASGLVVPEGCRGRSTWERQGQAAELAVRRLAGAYGADDLSVVRTEGGGDAEGDGWLVTVAHRDGRAWDVPIAPRAAAVATPASCGAAPVAQTRMAAGPPRLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-10-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NB00</accession>
    <name>A0A0F7NB00_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_29435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018909.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH85680">
        <property type="protein sequence ID" value="AKH85680"/>
        <property type="gene ID" value="AA958_29435"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_29435"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6211"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="135" mass="13457" checksum="A82A741BCE741595" modified="2015-07-22" version="1">MTSSANSQADTASPACCGAPAAAPAPQNTAAQQQPREVLIITDSCCNPAAAPAEERAVKTVTEAITATGSPARARLVSATEALAGALSPEILAEIQSQLVRGTARPPMVMIAGQIVASGNFTQQEVEAALAGTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NB75</accession>
    <name>A0A0F7NB75_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AA958_27430</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018580.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_27430"/>
    <dbReference type="EnsemblBacteria" id="AKH85346">
        <property type="protein sequence ID" value="AKH85346"/>
        <property type="gene ID" value="AA958_27430"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_27430"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5780"/>
    <dbReference type="OrthoDB" id="54580at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004589">
        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006293">
        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002121">
        <property type="entry name" value="HRDC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044876">
        <property type="entry name" value="HRDC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032284">
        <property type="entry name" value="RecQ_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018982">
        <property type="entry name" value="RQC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00570">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16124">
        <property type="entry name" value="RecQ_Zn_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09382">
        <property type="entry name" value="RQC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00341">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00956">
        <property type="entry name" value="RQC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="SSF47819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01389">
        <property type="entry name" value="recQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00614">
        <property type="entry name" value="recQ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50967">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="27"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="216"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="HRDC" evidence="9">
        <location>
            <begin position="533"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AKH85346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="609" mass="66522" checksum="0D9744EA5D2E44AA" modified="2015-07-22" version="1">MSSTEALQVLSKVFGYESFREGQQEIIDHVVGGGDALVLMPTGGGKSLCYQIPALVRPGTGVVISPLIALMQDQVDALRALGVRAGFLNSTQDPDERRMVEAEFLAGEIDLLYLAPERLRVESTMRLLDRGTVALFAIDEAHCVAQWGHDFRPDYLALSALSERWPDVPRIALTATATKATHAEIASRLQLEQARHFVASFDRPNIQYRIVPKREPKKQLLELLRTEHAGDAGIVYCLSRKSVEDTAAFLVENGIDALPYHAGLPAATRAEHQSRFLREEGMAIVATIAFGMGIDKPDVRYVAHLDLPKSVEGYYQETGRAGRDGQPSTAWLAYGLQDVVQQRKLIDGSEGDDAHRRRASAHLDAMLALCESVDCRRSQLLAYFGQSGSPCGNCDTCLTPPESWDGTVAAQKLLSTVVRLRRERRQKFGAGQIVDILMGRKTAKVIQHDHDTLSVFGVGDDLAEHEWRGVVRQLLAKGLLAVEGDYGTLVLTEEADEVLYRGRKVPLRTEPKRAAKAAKAKSGSKRAEAVDLPAEAASLFERLRAWRGATAKEQGVPAYVIFHDATLRQIATERPGSLASLGSVSGVGENKLAKYGEQILAVVAEDDAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBI9</accession>
    <name>A0A0F7NBI9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AA958_28395</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018745.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_28395"/>
    <dbReference type="EnsemblBacteria" id="AKH85511">
        <property type="protein sequence ID" value="AKH85511"/>
        <property type="gene ID" value="AA958_28395"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_28395"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5984"/>
    <dbReference type="OrthoDB" id="692375at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="57"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="9">
        <location>
            <begin position="86"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="147"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AKH85511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="364" mass="38960" checksum="696DCDDAEA22C9A3" modified="2015-07-22" version="1">MNRRPGLSVRVKLTLSYAGFLMLAGALLLAAIGLFLVREGWLQTNAEGAWRATPGTHFVRGFAPTAAAVMLFLLGFGLLGGWILSGRMLAPLTRITDATRMATNGSLSHRIRLPGRSDEFRELADAFDTMLARLEAHVAEQRRFAANASHELRTPLAISKSLLDVARSDPAHEPGKLVDRLSTVNARAIDLTEALLVLSRAEQRSFSREHVDLSLLAEEATEALLPLAEKRGVTIETSGDITPAFGSTALLLQLTTNLVHNAIVHNLPEHGVVRVRTGAHGTGAVLIVENTGEHISPELAPTLTEPFQRGTERVHSDRAGVGLGLAIVETLTHAHDGTLTLTPRSSGGLRVTVVLPPAPPPARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBK2</accession>
    <name>A0A0F7NBK2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_19975</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017372.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH84082">
        <property type="protein sequence ID" value="AKH84082"/>
        <property type="gene ID" value="AA958_19975"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_19975"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4208"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH84082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="67" mass="6829" checksum="2536552F9198B56B" modified="2015-07-22" version="1">MSSASIAPPRGAADTGRAADAPQPDSPHIATVAARATRHHLHTAWRAVTAFGGAVVAVVVLGEYADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBS8</accession>
    <name>A0A0F7NBS8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_24750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018131.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_24750"/>
    <dbReference type="EnsemblBacteria" id="AKH84879">
        <property type="protein sequence ID" value="AKH84879"/>
        <property type="gene ID" value="AA958_24750"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_24750"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5220"/>
    <dbReference type="OrthoDB" id="1670369at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH84879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="137" mass="14416" checksum="A2F05270ECAACBFE" modified="2015-07-22" version="1">MTRSPAVPGGTLVLDSEGLAKAVLRDRAVTTWLALARADDLRVITSAATLVEVIHPRINRPALEWTLSRLVVEPVTEPIARHAAVLLADAGLHGHKHAIDAMLSATALAAPAPVTVLTSDTEDLIPLCGTRATVIKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBZ6</accession>
    <name>A0A0F7NBZ6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lar_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_29850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018959.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_29850"/>
    <dbReference type="EnsemblBacteria" id="AKH85731">
        <property type="protein sequence ID" value="AKH85731"/>
        <property type="gene ID" value="AA958_29850"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_29850"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6304"/>
    <dbReference type="OrthoDB" id="313921at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050043">
        <property type="term" value="F:lactate racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043166">
        <property type="entry name" value="LarA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018657">
        <property type="entry name" value="LarA-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09861">
        <property type="entry name" value="Lar_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lar_N" evidence="1">
        <location>
            <begin position="7"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="426" mass="44693" checksum="28D6157CEFFD9A3C" modified="2015-07-22" version="1">MRVQLAYGEHGLGIEVPETATVVAPVHRSGARDPSAVLRTALREPVAGPPLRERVRPGQTVAISACDGTRPQPRHLMIPALLAELDGIVRPEDVVILVATGTHRGNTDAELRRMFGDAVVDTVRVVNHDASDRAGLTWMGTHGAGVPVWLNSEWAAADVRITTGFVEPHFFAGFSGGPKLVAPGLAALETVLVLHDAARIADERATWGITHGNPVHDDVRAIAAGTGVTFALDVVLNRGQEIVAAFGGDLPAMHAAATAEAARTAMRPVGTRYDVVVTTNSGFPLDQNLYQAVKGMSAGYQVVRPGGTIICAAECRDGFPDHGSYREVLSSAPSPQALLDAIGARTETVPDQWQVQIQAAILARCRVVMHTDGLSAADLAAAHLEQTGDVTAAVAEALAAAGPAARLCVLPEGPQTIPYLRETIAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCC6</accession>
    <name>A0A0F7NCC6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FMN_red domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_26155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018370.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_26155"/>
    <dbReference type="EnsemblBacteria" id="AKH85129">
        <property type="protein sequence ID" value="AKH85129"/>
        <property type="gene ID" value="AA958_26155"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_26155"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5506"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN_red" evidence="1">
        <location>
            <begin position="11"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="183" mass="19230" checksum="2F64B94862A28B50" modified="2015-07-22" version="1">MSTDVTLRLTVLGGLGPGRAAGAEARRLAGLAGRRARLEVDLIDLAAACLPEPCPGVLPGDAPEPPAVRELRPWLDAADGFVVVAPAAAGQQPAGQSPAGQHSAGPLQRALVWCAEAFKARPVALHVRAGEGTARALRTLRADLAEAHALTVHETDCPDHALDELIWWARALRTARARTPYPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCF9</accession>
    <name>A0A0F7NCF9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosome-binding factor A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rbfA</name>
        <name evidence="3" type="ORF">AA958_26315</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RbfA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018400.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_26315"/>
    <dbReference type="EnsemblBacteria" id="AKH85159">
        <property type="protein sequence ID" value="AKH85159"/>
        <property type="gene ID" value="AA958_26315"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_26315"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5540"/>
    <dbReference type="OrthoDB" id="1971380at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00003">
        <property type="entry name" value="RbfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000238">
        <property type="entry name" value="RbfA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023799">
        <property type="entry name" value="RbfA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020053">
        <property type="entry name" value="Ribosome-bd_factorA_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33515">
        <property type="entry name" value="PTHR33515"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02033">
        <property type="entry name" value="RBFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89919">
        <property type="entry name" value="SSF89919"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00082">
        <property type="entry name" value="rbfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01319">
        <property type="entry name" value="RBFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="121"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH85159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="175" mass="18295" checksum="DB9536304C921BE1" modified="2015-07-22" version="1">MADNARAKRLADLIREVVAEKLQRGIKDPRLGSRVTITDTRVTGDLREATVFYTVYGDDEERAQAAKGLESAKGVLRSAVGAAAGVKFTPTLAFVPDALPENAKNIDDVLERARLQDEQVRSAAAGAEYAAGADPYKRDRDEDGADDGADDGEADPGEPGPGAARGDKDGGPAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCN2</accession>
    <name>A0A0F7NCN2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_33035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019472.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86245">
        <property type="protein sequence ID" value="AKH86245"/>
        <property type="gene ID" value="AA958_33035"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_33035"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="72" mass="7398" checksum="B251C7E632093482" modified="2015-07-22" version="1">MEWWWVAAAVLLGGAGVVAAGFRQAADSPRRLSGRSQRAARGLSVVLIGVAVFFGLLVAVGKFLLTTGNGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCR5</accession>
    <name>A0A0F7NCR5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Chitinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AA958_22485</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_22485"/>
    <dbReference type="EnsemblBacteria" id="AKH84507">
        <property type="protein sequence ID" value="AKH84507"/>
        <property type="gene ID" value="AA958_22485"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_22485"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4732"/>
    <dbReference type="OrthoDB" id="1081028at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003305">
        <property type="entry name" value="CenC_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02018">
        <property type="entry name" value="CBM_4_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519367" evidence="6">
        <location>
            <begin position="45"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="7">
        <location>
            <begin position="188"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="8">
        <location>
            <begin position="278"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH84507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="568" mass="57897" checksum="DBE5A6CB9847EEA1" modified="2015-07-22" version="1">MFRARRPRTPRTARTARGSFRRLAVAAAGGLLATLLGAPLAASAEPNLVQNPGFESGLSGWTCSGTAGTTVASPVHSGTAALRATPAGQDNARCTQSVAVRPNSAYELSAWVQGSYIYLGAGGTGTTDVSAWTSGASSYTQLKTSFTTGPNTTSVTVYTHGWYGQPAYHADDVSLTGPGGDPGTVPATPTGLQVTGTAARSVSLGWSPVTGATGYNVYRDGTKVLSTGGASATVTGLTPSTAYRFQVTATNAAGESPKSAAATGTTTPDGGGPGVPKHAVTGYWQNFNNGAAVQKIRDVSSQYDIIAVAFADATAAPGAVTFNLDSAGLGGYTVAEFKQDIAAKQQAGKSVIISVGGEKGTVAVNSSTAAANFANSLYSLMTEYGFDGVDIDLENGLNSTYMTQALRSLSQKAGPDLVITMAPQTIDMQSTAGEYFKTALNIKDILTVVNMQYYNSGTMLGCDGGVYAQGTINFLTALACIQLEGGLAPSQVGLGLPASTRAAGGGYTAPSVVNAALDCLTRGTNCGSFKPPRTYPDLRGAMTWSTNWDATAGNSWSGAVGPHVHALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCS7</accession>
    <name>A0A0F7NCS7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Acyl-CoA transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_33280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019515.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_33280"/>
    <dbReference type="EnsemblBacteria" id="AKH86290">
        <property type="protein sequence ID" value="AKH86290"/>
        <property type="gene ID" value="AA958_33280"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_33280"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.7029"/>
    <dbReference type="OrthoDB" id="969868at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="SSF89796"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH86290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="414" mass="43457" checksum="316D145606EB19C0" modified="2015-07-22" version="1">MTDTPASAASDAAATDAPAPQAPLAGLRVLDLATLFAGPLAATMLGDFGAEVVKVEHPARPDPSRGHGPAKDGVGLWWKLLGRNKKNLTLDLSTPGGRDVLLRLAAGSDVIVENFRPGTLEKWGLGWAELSAANPRLVLARVTGFGQFGPYARRPGFGTLAEAMSGFAAVTGEPDGPPTLPPFGLADSVAALSTAYAVMTALAGRERTGRGQVVDMAIIEPMLTVLGPQPLWYDQLGYVQPRTGNRSTNNAPRNTYRTADGRWLAVSTSAQSIAERVMRLVGRPELIDEPWFGTGAGRAAHAGELDEAVGGWIARHDAATVVAAFEKAQAAVAPVYDIRDVMADEQYRALGSITEVEDEELGTVKMQNVLFRLSETPGAIRWAGRPHGADTDAVLAGLGLTGAEIAGLRDEGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCY7</accession>
    <name>A0A0F7NCY7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA ligase (ATP)</fullName>
            <ecNumber evidence="1">6.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_31995</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.5.1.1" evidence="1"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019304.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_31995"/>
    <dbReference type="EnsemblBacteria" id="AKH86076">
        <property type="protein sequence ID" value="AKH86076"/>
        <property type="gene ID" value="AA958_31995"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_31995"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6756"/>
    <dbReference type="OrthoDB" id="1073940at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07905">
        <property type="entry name" value="Adenylation_DNA_ligase_LigC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07970">
        <property type="entry name" value="OBF_DNA_ligase_LigC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044119">
        <property type="entry name" value="Adenylation_LigC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012309">
        <property type="entry name" value="DNA_ligase_ATP-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016059">
        <property type="entry name" value="DNA_ligase_ATP-dep_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044117">
        <property type="entry name" value="OBF_LigC-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04679">
        <property type="entry name" value="DNA_ligase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00697">
        <property type="entry name" value="DNA_LIGASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_LIGASE_A3" evidence="3">
        <location>
            <begin position="11"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="DNA_ligase_A_C" evidence="4">
        <location>
            <begin position="215"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH86076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="361" mass="40402" checksum="E876159BC18A06B7" modified="2015-07-22" version="1">MDLPVMPPVKPMLAKPQKKLPPGMLYEAKWDGFRAIVFRDGAEVEIGSRTGKPLTRYFPELVEALQANLPERCVLDGEIVIVRGDRLDFDALTERIHPADSRVRMLAEQTPASFVAFDLLALGDDSLLDTAQSERRAALLRALAGARAPVHIAPATTDLAVAGEWFEQYEGAGLDGIIAKPADLPYRQNERVLVKVKHERTADVVLAGFRWHKSGPVVGSLLLGINDDKGVLQHVGVCAAFSMTRRAELVEELAPLRMETPEEQAAHPWADWAKEEAHESARLPGAPSRWSGQKDLSWVPLRPERVLEVAYDHMENGARFRHTAQFRRWRPDRTPESCTYEQLEEPVTYDLNEVLATPKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7ND17</accession>
    <name>A0A0F7ND17_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_26980</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018514.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_26980"/>
    <dbReference type="EnsemblBacteria" id="AKH85278">
        <property type="protein sequence ID" value="AKH85278"/>
        <property type="gene ID" value="AA958_26980"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_26980"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5677"/>
    <dbReference type="OrthoDB" id="1181903at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="24"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="60"/>
            <end position="67"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH85278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="256" mass="26783" checksum="63C8D1F57701E665" modified="2015-07-22" version="1">MSEETGREGTAVRERAAAGAGAMVVVEDLHRTYGGGATAVHALRGVSLRVPRGELVALKGRSGSGKTTLLNLVAGLDVADSGRIELDGVALSGLGEAELLELRRDRIGLVFQSFGLIPILSAAENVGVPMRLRKVPPREREERVELLLALVGLADHAAQRPGELSGGQQQRVAIARALANRPALIIADEPTGQLDAETGHAVMELLRAVVRSEGVTVLVATHDAALLDLADRVLELRDGTITDHPQAGTAGEPPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7ND81</accession>
    <name>A0A0F7ND81_9ACTN</name>
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        <submittedName>
            <fullName evidence="2">Sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_23670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017962.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_23670"/>
    <dbReference type="EnsemblBacteria" id="AKH84707">
        <property type="protein sequence ID" value="AKH84707"/>
        <property type="gene ID" value="AA958_23670"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_23670"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4989"/>
    <dbReference type="OrthoDB" id="447734at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519519" evidence="1">
        <location>
            <begin position="23"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="428" mass="45904" checksum="AB4D8D004024D90C" modified="2015-07-22" version="1">MKRTAVAVLAAAGLVASLAACGSDDGDEAGDKGGGAKSFKGETLTFWAMDGSTPDDWLKDVEAEFEKKTGAKLEYKVQQWNGIQQKLTTALSEESPPDVVEVGNTQTPAYAATGGLADLTELKEEIGTEWTESLNESSVYEGAQYAVPWFFANRVVMYNKSIFKEAGITEIPKTRDDLFAAFDKIEKNTDAEPIYMPGQNWYFFDGLLIGQDAELVKQDGDKWVSNLSDPKVGAAMEIYKQYADYSTAPKDKDEATPQQGEVFGKGKTGAIIGMGWESGIAVEASKDKNFEKEIGYFTIPGETADTPESVFLGGSNLAVAAGSEKQELAQEFLRIVLSDKHEGALAAANGVIPNKDSLLSKLEGNEAAEAAAPAAAVGGTTPLIPEWGAVENTPNPIKSYMTAYLNGDSHEEAAKSVEDDLNERLAQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDB1</accession>
    <name>A0A0F7NDB1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_01180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019696.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_01180"/>
    <dbReference type="EnsemblBacteria" id="AKH86475">
        <property type="protein sequence ID" value="AKH86475"/>
        <property type="gene ID" value="AA958_01180"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_01180"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.260"/>
    <dbReference type="OrthoDB" id="1779320at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH86475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="315" mass="32670" checksum="9C91FC50863D8127" modified="2015-07-22" version="1">MWPGQQPGGEQHQQPNPYQQQPAPHGPQGYDGQQQHQQQEQWGQSTPPGAPVPGKSGTTPRVAVAIIGAVAVIAAAAVTGVVLLNEDDGGGGKASPGGGGGSPSASASPSPSEKPVLQDDPDNPRGVAADQKIEPVVSGWKAVYNAKRHNVYDVPPEWEVQSPTMTIGFEDDSGPLVSMTGAALYKDGICKYASRAGAGTKGGIGAKNTKEAVENEAGAWAEAAFNTSKKATVKQTEPVAFSSKHGLKGHMATATVTGVPRETKCSADGKVVAFTYTDVNGEFATWVLYTDTGVDDEVPEDTIAKIMDSLRPLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDH0</accession>
    <name>A0A0F7NDH0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dynein regulation protein LC7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_24005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018019.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_24005"/>
    <dbReference type="EnsemblBacteria" id="AKH84767">
        <property type="protein sequence ID" value="AKH84767"/>
        <property type="gene ID" value="AA958_24005"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_24005"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5059"/>
    <dbReference type="OrthoDB" id="1635683at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004942">
        <property type="entry name" value="Roadblock/LAMTOR2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03259">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00960">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Robl_LC7" evidence="1">
        <location>
            <begin position="15"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="139" mass="14350" checksum="B0F4EB86EA983FC3" modified="2015-07-22" version="1">MNSTQEHRDTISSLRWMLDNFTAEVPGVRSVVVVSVDGLPLLAAPPQSASAGEQLATVVSGIGGLTNGAADVMDGGRVKQTMVAMEDGCLVVMEAGDGSLLGVLTEPDCDLSVAAYHMELFVGRVGHVLTPGLRGELTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDQ5</accession>
    <name>A0A0F7NDQ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_28735</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018802.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH85569">
        <property type="protein sequence ID" value="AKH85569"/>
        <property type="gene ID" value="AA958_28735"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_28735"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6056"/>
    <dbReference type="OrthoDB" id="767622at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="2">
        <location>
            <begin position="94"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH85569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="343" mass="37933" checksum="258B9AA5DF61188F" modified="2015-07-22" version="1">MTSQSQRTGAAGPAAPTGRSGTEPRPLGEIRRWPRSFTDRLNAPLPGIGMLARLARTGQFRPSARTLEEIPELPYEPGPLPAAGPATVAVTWAGHASWVLRIGGLTVLTDPLWSRRILGTPARVTPVGVRWEDLPPVDAVVVSHNHYDHLDRPTLKRLPRTTPLFVPAGLARWCRRRGFTRVTELDWWEAAELPAPGGPVRFDFVPAHHWSKRTLTDTCRSLWGGWVLTDGAGRRIYFAGDTGYGHFFEEIGRRLPGIALALLPIGAYSPRWMLGPVHMDPEQAVRACGDVGARRMAPMHFGTFLLSAEPPLEPLRRVRAAWERTGRPRAELWDLPVGASRVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NE08</accession>
    <name>A0A0F7NE08_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_29550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018923.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_29550"/>
    <dbReference type="EnsemblBacteria" id="AKH85694">
        <property type="protein sequence ID" value="AKH85694"/>
        <property type="gene ID" value="AA958_29550"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_29550"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6236"/>
    <dbReference type="OrthoDB" id="453021at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amino_oxidase" evidence="1">
        <location>
            <begin position="13"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="546" mass="57707" checksum="2C3F67BAC3AC53C4" modified="2015-07-22" version="1">MSDAVVVGAGPNGLVAANVLADAGWSVTVLEEQPVPGGAVRHDRGVHPDYVSDVFSSFYPLAAASPVLRRLRLEEYGLRWSHAPAVVAHPLTDGRCAVLDRRAEVTADSLEAFGPGDGAAWRRLYALWEDVRADVLDALFTPFPPVRPAVRLGRRLGVAGGLRLARSLTLPVRRLGEEEFAGEGGRILLAGNALHADLPPEAAGSGGFGWLMTMLGQSYGFPVPVGGSGELARALVARLEARGGTVLCGRRVTEVVVRGGRAVGVRTVDGESVAASGAVLADVSVPVLYGELVAAEHVPRQVLADVRRFQWDFGTFKVDWTLDEPAPWQCAGAAGAGTVHLADGMDELTRFAAQLAMDQVPDRPFLLFGQMTTADATRSPIGTESAWAYTHLPQRIRSDAGEEGIRGTWSRHEQEVMADRVEQQVERFAPGFRSLVCARRVLAPPTLQSLDRNLHGGAVNGGTAAMHQQLFFRPGPGTGRPETAVPGLFLASAGAHPGGGVHGAPGANAARAALRCRTPAALTAVQRCLAGRDGTRGKRRGGRRAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NEB2</accession>
    <name>A0A0F7NEB2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNA polymerase sigma 70</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_30300</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Interacts transiently with the RNA polymerase catalytic core formed by RpoA, RpoB, RpoC and RpoZ (2 alpha, 1 beta, 1 beta' and 1 omega subunit) to form the RNA polymerase holoenzyme that can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019027.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH85799">
        <property type="protein sequence ID" value="AKH85799"/>
        <property type="gene ID" value="AA958_30300"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_30300"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6401"/>
    <dbReference type="OrthoDB" id="1914729at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="13"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="7">
        <location>
            <begin position="108"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH85799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="284" mass="31061" checksum="B4F76EE75BFEE939" modified="2015-07-22" version="1">MDEHEALLAEQFEEARDHLRAVAFRMLGSVTEADDAVQEAWLRLSRSREDGIRNLHGWLTTVVSRVCLDMLRARRRRREDLVESSVLAVGGGSDPVEQVLLADSVGLALLVVLESLEPAERLAFVLHDLFNVPFDEIAPIVERTPAAARKLASRARRRVRGGHLLSEPDLARRREVVEAFLSAARTGDFDSLISVLDPDVESRNNGVPRARGALAVAKGASSFAQIARFAQPALINASPGVIAAHAGQGVRVITFEMRDRMITVIDVITDPARLLALDMALLDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NEC3</accession>
    <name>A0A0F7NEC3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase_M23 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_08315</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019864.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_08315"/>
    <dbReference type="EnsemblBacteria" id="AKH86611">
        <property type="protein sequence ID" value="AKH86611"/>
        <property type="gene ID" value="AA958_08315"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_08315"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1754"/>
    <dbReference type="OrthoDB" id="1891666at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M23" evidence="2">
        <location>
            <begin position="211"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="89"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH86611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="325" mass="35615" checksum="D82A0C6333256C70" modified="2015-07-22" version="1">MRGTVDRLFRDAAAATERYEAARRASAAQRVKIAKLQRAVRAQHRRLVVLRGRIGQLAAHHYRSGGLGPTAALMSARTPEDLLDRVFLLDKGEQAAAGLYHRAEQAERRLADERERQAVALADLRAELHTQARVKRFIERKLERAQGRLDGLQTAQAARSRSSACPRGERSRAVTLSADGKALAGRKWTAPVGRYTLSSRFGQAGGMWSSRHTGLDFAVKEGKPVGSVGYGVVYEIGCDDAFGNSVTVRHDDGYYTFYAHLSEVRAKPGERVFPGQPLGRAGTTGNSTGPHLHFEARVTPQFGSGIDPEPWLRGKGVRLREAPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NED5</accession>
    <name>A0A0F7NED5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH tetR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_08845</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019884.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86626">
        <property type="protein sequence ID" value="AKH86626"/>
        <property type="gene ID" value="AA958_08845"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_08845"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1863"/>
    <dbReference type="OrthoDB" id="1437290at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011075">
        <property type="entry name" value="TetR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16859">
        <property type="entry name" value="TetR_C_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="10"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH86626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="192" mass="21104" checksum="E8E5BB930707781F" modified="2015-07-22" version="1">MERGPDPRAVRSRAAALDAARALLVEQGWAAVTHVSVAARSGVGRTTLYRHWPDPAEMIRDAITEGLTIAHVRRTGELRRDLLGELNVVRRWLHDPTAERALRAVIERVSVDPAYGELKTSLYTAASEGLCAIVDTARERCELPAGLDTDLAVDQLSGPLMFRRLVAERTFDGGFVESVVDFFLSAYDDTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NEE1</accession>
    <name>A0A0F7NEE1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">D-alanine--D-alanine ligase</fullName>
            <ecNumber evidence="7">6.3.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">D-Ala-D-Ala ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">D-alanylalanine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ddl</name>
        <name evidence="11" type="ORF">AA958_25770</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Cell wall formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + 2 D-alanine = ADP + D-alanyl-D-alanine + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:11224"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57416"/>
            <dbReference type="ChEBI" id="CHEBI:57822"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="8">Binds 2 magnesium or manganese ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the D-alanine--D-alanine ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.4" evidence="7"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018308.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_25770"/>
    <dbReference type="EnsemblBacteria" id="AKH85062">
        <property type="protein sequence ID" value="AKH85062"/>
        <property type="gene ID" value="AA958_25770"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_25770"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5428"/>
    <dbReference type="OrthoDB" id="764798at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008716">
        <property type="term" value="F:D-alanine-D-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00047">
        <property type="entry name" value="Dala_Dala_lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000291">
        <property type="entry name" value="D-Ala_lig_Van_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005905">
        <property type="entry name" value="D_ala_D_ala"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011095">
        <property type="entry name" value="Dala_Dala_lig_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011127">
        <property type="entry name" value="Dala_Dala_lig_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07478">
        <property type="entry name" value="Dala_Dala_lig_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01820">
        <property type="entry name" value="Dala_Dala_lig_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039102">
        <property type="entry name" value="Ddl/VanB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01205">
        <property type="entry name" value="D_ala_D_alaTIGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00843">
        <property type="entry name" value="DALA_DALA_LIGASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 7 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="10">
        <location>
            <begin position="164"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR039102-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AKH85062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="389" mass="41692" checksum="9D158D75B28B9236" modified="2015-07-22" version="1">MSSEHSYESQGRKPRVAVVFGGRSSEHGISVVTAGAVMAAIDRDKYEVLPIGITADGRWALTADDPARMAIADRQVPRVEELVDDEAEDGAVVLSADPGSREVVYAEPGQVPKALGEVDVVFPMLHGPYGEDGTLQGMLDLSGVPYVGSGVLASAVGMDKEYMKRVFVSYGLPVGPYVVIRPREWDQGAPGQEGAAARKKIVDFAADHGWPVFVKPARAGSSIGITKVGELGALEDALAEARRHDPKIIVEAAVEGREIECGVLEFEDGPRASVPAEIPPTTSHDFYDFEAKYIDSAAGIVPAPLTAEETAEVQRLAVAAFEACSCEGLVRADFFRTADGGFVINEINTMPGFTPISMYPRMWQESGVSYPELVDRLIQAALRRSTGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NEE3</accession>
    <name>A0A0F7NEE3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fe/B12 periplasmic-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_09130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_09130"/>
    <dbReference type="EnsemblBacteria" id="AKH86636">
        <property type="protein sequence ID" value="AKH86636"/>
        <property type="gene ID" value="AA958_09130"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_09130"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1924"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519412" description="Fe/B12 periplasmic-binding domain-containing protein" evidence="1">
        <location>
            <begin position="34"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="2">
        <location>
            <begin position="65"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH86636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="349" mass="36630" checksum="1FE302CF8D5B7E7C" modified="2015-07-22" version="1">MRVPAAAVAAVVVAVVAVVSAVVLWPNGGDGEAAPEKPAEAAADVFPVKVKHDYGETVVPSKPQRVAAWGWGAAEVAIALGEYPVGIVEEESESGKGMMPWVAQAYEDEGLDDPVLFTEGGSTSWGLPEEQIAATEPDLILAPYSGLTEAQYEQLTDIAPVVARPVGASVEPWEGVIATTAQALGVPAEGKELLAESDARLAELGERHGLTGSSFAAVVNDPPRRRVHVFSDASPVVRVLEGLGLRPADSVAELDSDGNGMMYSLDYEDLDRLESDVVVLYSTTSDWAERDLASEELNALPAFAAGRIAQLSGTDEFASATSPTVLSIRWPGGMPVLAESLEKAEAVRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NER9</accession>
    <name>A0A0F7NER9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcriptional repressor NrdR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">nrdR</name>
        <name evidence="11" type="ORF">AA958_26675</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the NrdR family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018459.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_26675"/>
    <dbReference type="EnsemblBacteria" id="AKH85222">
        <property type="protein sequence ID" value="AKH85222"/>
        <property type="gene ID" value="AA958_26675"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_26675"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5613"/>
    <dbReference type="OrthoDB" id="1551627at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00440">
        <property type="entry name" value="NrdR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005144">
        <property type="entry name" value="ATP-cone_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003796">
        <property type="entry name" value="RNR_NrdR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30455">
        <property type="entry name" value="PTHR30455"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03477">
        <property type="entry name" value="ATP-cone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00244">
        <property type="entry name" value="TIGR00244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51161">
        <property type="entry name" value="ATP_CONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0678">Repressor</keyword>
    <keyword evidence="6 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ATP-cone" evidence="10">
        <location>
            <begin position="46"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="zinc finger region" evidence="7">
        <location>
            <begin position="3"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="146"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="162"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AKH85222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="197" mass="20843" checksum="3337BFAA1CF1607E" modified="2015-07-22" version="1">MHCPFCRHPDSRVVDSRTTDDGAAIRRRRQCPDCSRRFTTVETASLMVIKRSGVTEPFSRAKVITGVRKACQGRPVTEDALAQLGQRVEEAIRATGSAEVSSHDVGLAILGPLQDLDLVAYLRFASVYRAFDSLEDFDDAITQLRTADRPPADSGGPDGQDDQAPPPAPGDPGAPGPGRSPGRGEAPGVPSPGRAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NET9</accession>
    <name>A0A0F7NET9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Penicillin-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_15970</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020113.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_15970"/>
    <dbReference type="EnsemblBacteria" id="AKH86811">
        <property type="protein sequence ID" value="AKH86811"/>
        <property type="gene ID" value="AA958_15970"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_15970"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3364"/>
    <dbReference type="OrthoDB" id="423699at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007887">
        <property type="entry name" value="MecA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
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        <property type="entry name" value="MecA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519376" evidence="2">
        <location>
            <begin position="33"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="MecA_N" evidence="4">
        <location>
            <begin position="52"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="3">
        <location>
            <begin position="261"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH86811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="531" mass="55394" checksum="5C9DDDE2EBF22897" modified="2015-07-22" version="1">MPEHRPRARRRRRRGPVLAAVAVVLAGGGYWAATAGPLDSGADGGGPADPEARRTAERFLGGWSAGEMKAAARLTDSPAEAERILSSFTEGLEIAKPKLTAGRARADGDNGAEVAYTAKMPVRGLGTWTYEATLPLVREDGGQWRVRWELGAVHPKLTETEKFRLVREESEELDAVDRDGGAVSAADHPSLAGVLGLGGGQPQGAVQVVDRHSGDVRSTEARFGPRRDPGDGTLRTTVDPELQGAAEAAMERHAGGRNAGLVALDMDSGEVLAAANSPAAGFNRAFQGTYAPGSTWKVLTTAALLNKGAVTPETTVDCPKYLTVGKQFHNVETSEIPGATFREDFIHSCNTAFVALRGSLGDEEMTDFAERYFGIGEEWSTGVPSFDGEVPVPGDETEKAASLFGQGRLRANPLVMASVTATAATGTFRQPVIVAGQEPSASAEELPEGVVEQLRALMRDTVTEGSAQVLAGLPGDVGAKTGTAEVTATGPNNGWLVAYRDGVAVACVVEDAESGSGDAGPVVRDVLEAVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NEW0</accession>
    <name>A0A0F7NEW0_9ACTN</name>
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        <submittedName>
            <fullName evidence="2">NmrA family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_16900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86831">
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        <property type="gene ID" value="AA958_16900"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_16900"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3556"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA" evidence="1">
        <location>
            <begin position="3"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="236" mass="25218" checksum="8982E13EA6BFD6A4" modified="2015-07-22" version="1">MPAALEGAAALFAVPPVAFGPDGSGVEQEFARGRALIDAATAVGVEHVVFTGIASTPGRLGGSEGKKRIEDYLRERIRSVTVLRPVRFMSNYLAAPPVGVDGIVHGVHRHIFPPDEPVQIIAVEDIAEFASLAFDRPDRFAGRTLELAGDAPTPAEAVAAISEATGTAVRYEQITHAEAVALNPEIAQVRERWAAGSRWHADIEALRVIHPGLRTLADWLAESGTALLRKRLLETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NEZ9</accession>
    <name>A0A0F7NEZ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Serine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AA958_27205</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the four-carbon acid sugar kinase family.</text>
    </comment>
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        <property type="protein sequence ID" value="AKH85307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_27205"/>
    <dbReference type="EnsemblBacteria" id="AKH85307">
        <property type="protein sequence ID" value="AKH85307"/>
        <property type="gene ID" value="AA958_27205"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_27205"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5732"/>
    <dbReference type="OrthoDB" id="771666at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037051">
        <property type="entry name" value="4-carb_acid_sugar_kinase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010737">
        <property type="entry name" value="DUF1537"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031475">
        <property type="entry name" value="NBD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042213">
        <property type="entry name" value="NBD_C_sf"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SBD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SBD_N" evidence="7">
        <location>
            <begin position="6"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="NBD_C" evidence="8">
        <location>
            <begin position="255"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH85307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="420" mass="42417" checksum="D335E31E2E304BF7" modified="2015-07-22" version="1">MTYEVAIVADDLTGAGDTAVQFAGAGWPTLLRLGGDRPGDTESGGDVAVVAITTDSRARPPAGAADLVREATTGLLRRGVTHLFKKVDSTVRGPVRAEIDAMLDVLSPGTVALVCPAFPAVGRTVVDGVLLVGGRPVGETAVGRDPVTPVTVSHLPTLLDAPLVRLDPRGAPAAWAAEVRAAGSRIVVLDAADDADLDRIARTIADLGERALAVGSAGLAGPLAARWRREARAPGAAPEDRAGSVPARDPAGTALVVVTSLHDASRAQAEALAAHSAEHLRPTARDLTEDDAWAGFLDRVRTAAAGRPDTLLLSTPDRGATAVDPELVARRVSDAAAHAVAAGSVAGLVATGGDGARAVLARLGGTGIRLYDTVEPGVPVGVVVGGPAAGLPVATKAGGFGSPDVLIKAAQAVRTERSHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NF35</accession>
    <name>A0A0F7NF35_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_32010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019307.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_32010"/>
    <dbReference type="EnsemblBacteria" id="AKH86079">
        <property type="protein sequence ID" value="AKH86079"/>
        <property type="gene ID" value="AA958_32010"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_32010"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6759"/>
    <dbReference type="OrthoDB" id="969875at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08298">
        <property type="entry name" value="CAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014187">
        <property type="entry name" value="ADH_Zn_typ-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02822">
        <property type="entry name" value="adh_fam_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADH_N" evidence="2">
        <location>
            <begin position="32"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH86079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="337" mass="35707" checksum="228E043D2CBBA2C6" modified="2015-07-22" version="1">MGATPPTSMRAWVVTAKGRLEPVELPVPEPGPDELLVRVEACGVCRTDLHVRDHDLPPHKTPVVPGHEAVGEVVAAGAAAERRIGSRVGIPWLRHTCGQCRWCERGQENLCPFSRYTGWDADGGYAEYAVVPAPYAYALPKEPAAEDLAPLLCAGIIGYRALRLAHLPPGGRLGLYGFGGSAHLTAQLALAEGAEVHVRTRSRAAQRLALELGAATAAGADEPALEPFDSAVLFAPAGELVPVALEALDAGGTLSVAGIHLTTIPELDYERHLFRERVLRSVTANTRADGREFLAAAAAHGVRPTVTPYPFDRADEALDDLAADRVRGAAVLRMDAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFC9</accession>
    <name>A0A0F7NFC9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">2-hydroxy-acid oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_31845</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
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        <property type="protein sequence ID" value="AKH86048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019276.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_31845"/>
    <dbReference type="EnsemblBacteria" id="AKH86048">
        <property type="protein sequence ID" value="AKH86048"/>
        <property type="gene ID" value="AA958_31845"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_31845"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6725"/>
    <dbReference type="OrthoDB" id="1186741at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02809">
        <property type="entry name" value="alpha_hydroxyacid_oxid_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012133">
        <property type="entry name" value="Alpha-hydoxy_acid_DH_FMN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008259">
        <property type="entry name" value="FMN_hydac_DH_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000138">
        <property type="entry name" value="Al-hdrx_acd_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00557">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0288">FMN</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="6">
        <location>
            <begin position="8"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="264"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="87"/>
            <end position="89"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="295"/>
            <end position="299"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="318"/>
            <end position="319"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH86048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="377" mass="38663" checksum="5055E9F5580FE198" modified="2015-07-22" version="1">MGPPGADSRGRTVHTLADVERAAAAVLPPGVRDFVAGGSGAETTLAANRAALNRVCVVPRALRDVSVCSTESTLLGRPVAMPVAVAPVAYHRLVCAEGETAAARAAKAAGVPFTASTLSSVPIEEITGAGGRIWFQLYWLRDTARTLDLVLRAEAAGCTAIMLTVDVPWMGRRLRDVRNGFALPGGVRAVHLAAADSTAHRRRSSASAVAAHTAEAFSPAVTWESVAALRARTRLPLILKGVLDARDARRAVDSGVDAIVVSNHGGRQLDGAVPSIDALPEVAAAVGSGCEVLMDSGVRGGTDVLRALALGASAVLVGRPVIWGLAAAGETGARRVLELLGDELRDALGLSGCTDVTDARELRTVRGAMSGCCGSAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFK1</accession>
    <name>A0A0F7NFK1_9ACTN</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_26850</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_26850"/>
    <dbReference type="EnsemblBacteria" id="AKH87051">
        <property type="protein sequence ID" value="AKH87051"/>
        <property type="gene ID" value="AA958_26850"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_26850"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5648"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007436">
        <property type="entry name" value="DUF485"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04341">
        <property type="entry name" value="DUF485"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH87051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="164" mass="17652" checksum="FE5A8A81F82A0A1C" modified="2015-07-22" version="1">MPASPAPGWGWDGWEPEPAPVPPPPRAAVGAGSGARGGDGEADDAVYLAVHATPEFQRVRSRYRRFVVPAALAFLVWYLSYVVAATAVPELMGRRVAGPLNVALLAGLGQFATTFLLTWAYARHARLRRDPAALDLRWDIAMRTRRPEGGPGPAPAHPEQEPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFN5</accession>
    <name>A0A0F7NFN5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_28540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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    </dbReference>
    <dbReference type="RefSeq" id="WP_047018771.1">
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH85537">
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        <property type="gene ID" value="AA958_28540"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_28540"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6013"/>
    <dbReference type="OrthoDB" id="1318943at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="247" mass="26654" checksum="108A45D0E7676F86" modified="2015-07-22" version="1">MSEPILVLVSAAAGLVVGAALGWYARGSLVGRRHRRRERFFGLPRNSEALVVVNRDAGGGDWSVAKHDALALLELSAVIKSCGAHVQVVAQDTAQQTFGDRTEFCVGTPISNRRMAAHMQSLLPGVRINTDPEPGPDRGAFAVGTERYRLENGVSEHVLLARLSAGQEARPVFLSCGQRSITNQAAMRYLVKNESRLNRKYGSNSFVLLLKVVNSQSYGPDVVELVGDVTKQAQTPLAQPNGKHGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NGD8</accession>
    <name>A0A0F7NGD8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_30430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_30430"/>
    <dbReference type="EnsemblBacteria" id="AKH85817">
        <property type="protein sequence ID" value="AKH85817"/>
        <property type="gene ID" value="AA958_30430"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_30430"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6431"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="62" mass="6574" checksum="C160DF79D95D997F" modified="2015-07-22" version="1">MPGGSIPGRSGDGSDGHGFLGRWQEEWVPRADGQEDYQEDEEQDEGGGGAGFAVGGPGRRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NGU4</accession>
    <name>A0A0F7NGU4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Methylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_02825</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019743.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_02825"/>
    <dbReference type="EnsemblBacteria" id="AKH86518">
        <property type="protein sequence ID" value="AKH86518"/>
        <property type="gene ID" value="AA958_02825"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_02825"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.604"/>
    <dbReference type="OrthoDB" id="1816476at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022446">
        <property type="entry name" value="CHP03704_MeTrfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004556">
        <property type="entry name" value="HemK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007848">
        <property type="entry name" value="Small_mtfrase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05175">
        <property type="entry name" value="MTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00536">
        <property type="entry name" value="hemK_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03704">
        <property type="entry name" value="PrmC_rel_meth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MTS" evidence="5">
        <location>
            <begin position="58"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="250"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH86518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="272" mass="27538" checksum="FEE287BF0606AEEA" modified="2015-07-22" version="1">MVARLRAAGCVFAEDEARLLRAAASTPAELDALVARRVAGWPLEQVLGRAEFCGLHIAVEPGVFVPRRRSEFLVRHAAEAAATAACPVVLDLCCGSGAIGAAIAAAVPGAELHAADVDPAAVRCARLNVGPGGTVYEGDLYAPLPGHLRGRVDVLVANAPYVPTAEVPFLPPEARDHEPLTALDGGADGLDVQRRVIAAAPEWLAPGGLLLVETSGRQEPRTRAAVAAAGLTAHTAVCADLAATVVTGRAPRAGGARPGAGPATRTPAPGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NH19</accession>
    <name>A0A0F7NH19_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_07520</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019840.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_07520"/>
    <dbReference type="EnsemblBacteria" id="AKH86593">
        <property type="protein sequence ID" value="AKH86593"/>
        <property type="gene ID" value="AA958_07520"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_07520"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1576"/>
    <dbReference type="OrthoDB" id="272464at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039535">
        <property type="entry name" value="ASST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14269">
        <property type="entry name" value="Arylsulfotran_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519490" evidence="2">
        <location>
            <begin position="23"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH86593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="510" mass="54704" checksum="BDE98A94218C35D4" modified="2015-07-22" version="1">MSRTCTAIVLGALAATLPPAAAAEETAEQAVAPAVAPDAVRGAAVPAAEEPSEPPPPPLDVLERRPGTGEGLLFVGPQKNPGRVGPPGEEPPPEAGRGPQILDDRGRPVWYHRIPQNEYVADFRVQEYRGRKVLTWWQGRSDSAGLGEGVGYIADENYDIIATVRSPDPEQSIDLHEFRLTPQGTALVVSYQQRPYDLTPVGGPADGDVLESVVWELDLATGEPLLEWRSLDHVPLQESDERPTGRAGTRPFDYLHTNSVSLDTDGDLLVSAVGTSTVYKLDRETGEIVWRLGGKNSDFRLGAGARTIAQHDVVAVGDGTYRMFDNQNLHSDGYESRVAWLRIDPRRGTAELERQLVHPDRVSTAVTGGSQGLPSGNTLVGWGSAGRISEFDAAGRLVFDAVFPEEYGSYRTYRDEWEGEPGTAPEVRIDGASGDAHAVWNGATEVAAWRVLAGDARDGLRPVAREPWDGLDTDVDLPADAADAAYVQAEALDADGEVIGASAVTETRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NHM3</accession>
    <name>A0A0F7NHM3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Long-chain fatty acid--CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_20535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_20535"/>
    <dbReference type="EnsemblBacteria" id="AKH86929">
        <property type="protein sequence ID" value="AKH86929"/>
        <property type="gene ID" value="AA958_20535"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_20535"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4332"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="49"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="636" mass="68206" checksum="5B2EC683A2A96EBF" modified="2015-07-22" version="1">MNSRLLPGTAVPPLLPPAVRADARGVREAEVPPAAPHAQHGSLADIPFDNAAHAPGEPALARPRADGTWADVTAAEFAEHVLAVAKGLIVHGLRPGDRLAIMSRTTYEWTLLDFAAWAAGLITVPVYPTSSAIQARHILHDSGALACAVESVEQARLISGRRQDLPHLAHLWQLDTGILGQLAAAGRDVPDTLVRQRRAGLGPASVATVIYTSGTTGLPKGCVLTHGNFLAEVDNAIELLYPLFTAVSEDPPATLLFLPLSHVLGRMTAIGCLRARVKLGHAPSIKTEDLLRDLAAFRPTFFVGIPYVLEKVFNTGRATAEGIGRAASFDRAAKVAVRYAEALEAELHGEGPGPGARLRALRKLYDALVYRRIRAALGGRVKYAICGGSPLGRRLAAFYAGADVMVFEGYGLTETTAAATVTPPLKPRFGTVGWPLPGTAIRIAHDGEVLVRGGHLFSGYWDAEAGVTRLDTDDGWFATGDLGELDADGYLTITGRKKDLIVTASGKNLAPAPLEDRLRAHPLVSQCLVVGDDRPYVAALLTLDPEGLQHWRMMRKRDYVPVTELVRDPLLRADLQRAVDGANELVSRAESIRRFAVLPADFTEEAGYVTPSMKLKRAAIVRDFGHVIDELYAAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NK48</accession>
    <name>A0A0F7NK48_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NIT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_31545</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020604.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_31545"/>
    <dbReference type="EnsemblBacteria" id="AKH87172">
        <property type="protein sequence ID" value="AKH87172"/>
        <property type="gene ID" value="AA958_31545"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_31545"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6663"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013587">
        <property type="entry name" value="Nitrate/nitrite_sensing"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08376">
        <property type="entry name" value="NIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519618" description="NIT domain-containing protein" evidence="3">
        <location>
            <begin position="23"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="303"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="NIT" evidence="4">
        <location>
            <begin position="53"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="627"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="731"/>
            <end position="747"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH87172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="846" mass="90253" checksum="76ABC43F12AA0585" modified="2015-07-22" version="1">MRLRTHLRILAAVVTAALAALAAVGAVRELNRAGAVQDYADTLERLQQPSFALVTELQAERRMTALHWARGPVNAAQLGNQQALTDEAAFALRELADEAPDSAVRPPLEAALRGVSGLTGVRERAAERSGDRDEALEAYTRAIEQTIAVHIRVRAHNGSLAQGSRPLTALLQAGESLALQDTLLAGAKDGRLTAADHARFVQAVGVQRFAYGTLAGPLLPDGEKDRYDAVTDSKEWAEKTRIEDAVLGVSRASGSPVTLPAATAGWQETYEHLGPGLTGLATARIQALADDAEDRAGELRMTAYAIAAGGVLLVAIVLGTVLWISRAIVRRAEEVRSSALAVARRQLPQMIVRLQRGEDVDLSALPAQVAAADEFGEISNVVARLAEEVVEAARVVHEERYGFEKFAEGVTMRSVTLIFAVLRTLDELQHRYADTDPALLSELYELDHLTVRVRRQLENLLVLSGGAVTNPHTEPVHIANLIVDAAGESRGFAQVTKEFQAEAWVVPEVAGELTHLIAELIENATTYSPSGYEVFVRATHTATGVAIEVEDKGRAPENWYFEALNGRLLDVPPYAVLAKSSDQLGLFVVGQLAQRHGVRVTLQQGRFGGVLAVVLVPSALLTGAPEQLADRTPVRKPLPGRSGPRPAKRREPTAAGLVRREPARGGGPTGPVRPIDPAPGLAPARPADDGVPDPERRRPPAPATPAGPAAEPQPATAAVPAAPAAPEHVRPEEPLPVRVKKPHPEPAPRPAPRSLPDPTEELPVTATPQIATEPTPEAEPAPAPARPAARAGGLPQRVPGTSMAGQLRDGRRRPATAMDRRPLDSIESAFTQLQEALTDPEEDSDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A097H0Y6</accession>
    <name>A0A097H0Y6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cellulose-binding protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Putative cellulose-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cnq743</name>
        <name evidence="4" type="ORF">AA958_30715</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="ChemBioChem" volume="15" first="2385" last="2392">
            <title>A Membrane-Bound Prenyltransferase Catalyzes the O-Prenylation of 1,6-Dihydroxyphenazine in the Marine Bacterium Streptomyces sp. CNQ-509.</title>
            <authorList>
                <person name="Zeyhle P."/>
                <person name="Bauer J.S."/>
                <person name="Steimle M."/>
                <person name="Leipoldt F."/>
                <person name="Rosch M."/>
                <person name="Kalinowski J."/>
                <person name="Gross H."/>
                <person name="Heide L."/>
            </authorList>
            <dbReference type="PubMed" id="25224759"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CNQ-509</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KJ451627">
        <property type="protein sequence ID" value="AIT42131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019091.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_30715"/>
    <dbReference type="EnsemblBacteria" id="AKH85863">
        <property type="protein sequence ID" value="AKH85863"/>
        <property type="gene ID" value="AA958_30715"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_30715"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6491"/>
    <dbReference type="OrthoDB" id="1005693at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004302">
        <property type="entry name" value="Cellulose/chitin-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03067">
        <property type="entry name" value="LPMO_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007384451" evidence="1">
        <location>
            <begin position="41"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-4" evidence="2">
        <location>
            <begin position="41"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIT42131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH85863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="225" mass="24915" checksum="68DF29A991299673" modified="2015-01-07" version="1">MSPPSNDRTDARSLPVRALLAVLAAAALLLTPWTGGTAQAHGSAADPVSRNYGCWQRWGSDFQNPDMQQQDPMCWQAWQHDTNGMWNWNGLYREGTGGNFQAHIPDNQLCSAGRTQDGRYDSMDTPGPWKTDSLGTNFTVDVLDQAYHGADYLYVYVTRQGYDAKTDALDWADLERVATAGPYGPANHYTANASAPGRSGHHIVYTIWKASHADQIYFFCSDVTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MXG0</accession>
    <name>A0A0F7MXG0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FAD_binding_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_00645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH80920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014286.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_00645"/>
    <dbReference type="EnsemblBacteria" id="AKH80920">
        <property type="protein sequence ID" value="AKH80920"/>
        <property type="gene ID" value="AA958_00645"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_00645"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.149"/>
    <dbReference type="OrthoDB" id="867226at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="4"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH80920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="500" mass="54466" checksum="7114D39D0605E9FE" modified="2015-07-22" version="1">MSEPVVVVGAGPAGLMLASELAMREVPAVLVDVHPAQRAEAPAMAINAGTLEMLDQRGLAAGLREGTVTFPEVRFADLRLAFEKVQGPREPTHMVLQSRLEKVLIDRAVELGVDLRWATRLTGFEEAADGSGVTVTLASDAGEETLRCRYLVGCDGRDSVVREGAGIDYVGDDWVIVRGIVGDVAINREDVAREQYGLSYTENGDQFLGAPLSPDVMRVFSAEFSTEPPEFEDGPATLEQLGDAVERLTGKELKATEAHWLRHYSIVTRNAEQYRKGRVFLAGDAAHVHYPYNGQGIGTAIGDAVNLGWKIAAEVHGWAPEGLLDSYHDERHLAGRLACMNIQAQLALLYPRPLARYMREMMAEFLKFDEVNVFLAELVTNLGPAVPIAYDGVPKSNEEDRLLGRRLPQVRIKTAAGDMGVAETLQSGRGVLLDLSGDASAQEESGWADRVEVVRAQPVPELPRTLLLRPDGCVAWHDGDGWGQDELRIALRAWFGAPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MY71</accession>
    <name>A0A0F7MY71_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">L-rhamnose mutarotase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_02190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014539.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_02190"/>
    <dbReference type="EnsemblBacteria" id="AKH81175">
        <property type="protein sequence ID" value="AKH81175"/>
        <property type="gene ID" value="AA958_02190"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_02190"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.471"/>
    <dbReference type="OrthoDB" id="1694303at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016857">
        <property type="term" value="F:racemase and epimerase activity, acting on carbohydrates and derivatives"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008000">
        <property type="entry name" value="Rham/fucose_mutarotase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05336">
        <property type="entry name" value="rhaM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH81175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="111" mass="12293" checksum="317A1139D08D8092" modified="2015-07-22" version="1">MAGAEQRRVCFLLKVRADRLAEYRERHAAVWPDMLAALSAAGWRNYSLFLRDDGLLVGYLETPDFAAAHAAMAASEVNARWQAEMAPFFEALDGAAPDAAVRPLTEVFHLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MYQ5</accession>
    <name>A0A0F7MYQ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATPase AAA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_03235</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014714.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_03235"/>
    <dbReference type="EnsemblBacteria" id="AKH81355">
        <property type="protein sequence ID" value="AKH81355"/>
        <property type="gene ID" value="AA958_03235"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_03235"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.689"/>
    <dbReference type="OrthoDB" id="977094at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032423">
        <property type="entry name" value="AAA_assoc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021886">
        <property type="entry name" value="MgsA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16193">
        <property type="entry name" value="AAA_assoc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12002">
        <property type="entry name" value="MgsA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="SSF48019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="3">
        <location>
            <begin position="61"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH81355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="462" mass="48584" checksum="7880FE81F14BF747" modified="2015-07-22" version="1">MEPDLFTAAAEERQEKDPGSSPLAVRMRPRSLDEVVGQQHLLKPGAPLRRLVGEGAGGPAGPASVLLWGPPGTGKTTLAYVVSQATQKRFVELSAITAGVKEVRAVIEGARRAAGGYGKETVLFLDEIHRFSKAQQDSLLPAVENRWVTLIAATTENPYFSVISPLLSRSLLLTLEPLTDDDVRGLLRRAVAAERGLGGAVTLPEESEEHLLRIAGGDARRALTALEAAAGAALAQGEAEVSLPTLEAAVDRAAVAYDRDGDQHYDVASALIKSVRGSDVDAALHYLARMIEAGEDPRFIARRLMISASEDIGLADSSALQTAVAAAQAVAMIGFPEAALTLAHATVALALAPKSNAVTKAIGAAMDDVRAGKAGPVPAHLRDGHYKGAEKLGHAQGYVYPHDIPGAIAAQQYAPDALAGRRYYEPTRYGAEARYAEVVERVRERLAGGGQDAPGRGGDGRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MZI4</accession>
    <name>A0A0F7MZI4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NUDIX hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_01860</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_01860"/>
    <dbReference type="EnsemblBacteria" id="AKH81121">
        <property type="protein sequence ID" value="AKH81121"/>
        <property type="gene ID" value="AA958_01860"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_01860"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.404"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="4">
        <location>
            <begin position="28"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH81121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="167" mass="18865" checksum="AF8400EED124BCA8" modified="2015-07-22" version="1">MYENRWFRVNLADVELPDGRHLDHYLIRLRPVAVATAVNEANEVLLLWRHRFITDVYGWELAAGVVEDGEDPETAAAREMEEETGWRPGPLTHLMTVEPSNGLTDARHLIYYATEAVQIGDPEDDFESDRREWVPLKGVPDMVGRGEVPAANMAAALLMLHHLRLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MZJ3</accession>
    <name>A0A0F7MZJ3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Hydrogenobyrinate a,c-diamide synthase</fullName>
            <ecNumber evidence="3">6.3.5.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Hydrogenobyrinic acid a,c-diamide synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cobB</name>
        <name evidence="7" type="ORF">AA958_05355</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L-glutamine or ammonia as the nitrogen source.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>2 ATP + 2 H2O + hydrogenobyrinate + 2 L-glutamine = 2 ADP + 2 H(+) + hydrogenobyrinate a,c-diamide + 2 L-glutamate + 2 phosphate</text>
            <dbReference type="Rhea" id="RHEA:12544"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:77873"/>
            <dbReference type="ChEBI" id="CHEBI:77874"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; adenosylcobalamin biosynthesis; cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route): step 9/10.</text>
    </comment>
    <comment type="domain">
        <text evidence="3">Comprises of two domains. The C-terminal domain contains the binding site for glutamine and catalyzes the hydrolysis of this substrate to glutamate and ammonia. The N-terminal domain is anticipated to bind ATP and hydrogenobyrinate and catalyzes the ultimate synthesis of the diamide product. The ammonia produced via the glutaminase domain is probably translocated to the adjacent domain via a molecular tunnel, where it reacts with an activated intermediate.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="3">The a and c carboxylates of hydrogenobyrinate are activated for nucleophilic attack via formation of a phosphorylated intermediate by ATP. CobB catalyzes first the amidation of the c-carboxylate, and then that of the a-carboxylate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CobB/CbiA family.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.9" evidence="3"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015074.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_05355"/>
    <dbReference type="EnsemblBacteria" id="AKH81720">
        <property type="protein sequence ID" value="AKH81720"/>
        <property type="gene ID" value="AA958_05355"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_05355"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1123"/>
    <dbReference type="OrthoDB" id="692368at2"/>
    <dbReference type="UniPathway" id="UPA00148">
        <property type="reaction ID" value="UER00220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042242">
        <property type="term" value="F:cobyrinic acid a,c-diamide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043802">
        <property type="term" value="F:hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolysing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00027">
        <property type="entry name" value="CobB_CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004484">
        <property type="entry name" value="CbiA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002586">
        <property type="entry name" value="CobQ/CobB/MinD/ParA_Nub-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011698">
        <property type="entry name" value="GATase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43873">
        <property type="entry name" value="PTHR43873"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01656">
        <property type="entry name" value="CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07685">
        <property type="entry name" value="GATase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="2 3" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CbiA" evidence="5">
        <location>
            <begin position="7"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="GATase_3" evidence="6">
        <location>
            <begin position="318"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="252"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="400"/>
        </location>
    </feature>
    <feature type="site" description="Increases nucleophilicity of active site Cys" evidence="3">
        <location>
            <position position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH81720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="514" mass="51640" checksum="7BD74B24EF1A1C78" modified="2015-07-22" version="1">MIDIPRLVVAAPASGSGKTTVATGLMAAFAAAGLTVSPHKAGPDYIDPGYHALAVAGSPGGGRPGRNLDAHMCGPGLIAPLFAHGAAGADVAVVEGVMGLYDGASGAGESGSTAELAKLLRAPVVLVVDASGQSRSVAALVHGFASWDPEVRIGGVVLNKVASDRHESLLRESLDAAGVPVLGALRRDPELAAPSRHLGLIPAAERRPAAVAAVRALAARVRESCDVPELLRLARTAPLLPADPWSAADAVAAAGQQGGPGAGGDRAAGAAPGARGRSPRSAPRAAGAGDAEGPGAGPRFREGAGSGNSPRPAGRPVVAMAAGPAFTFSYAEHAELLAAAGADVVPFDPLHDEALPPRTRALVIGGGFPEVYGAELAANEPLRRDVARRAAGGAPVAAECAGLVYLARDLDGAPMCGVLDARARMTGLLTLGYRDAVAVADSALAAAGTRVRGHEFHRTALDPPAGETPAWGMTQPVRRVEGFVRGGVHASYLHVHWAAAPAMARRLVEGCETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MZQ1</accession>
    <name>A0A0F7MZQ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Rhamnose isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_02220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014545.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_02220"/>
    <dbReference type="EnsemblBacteria" id="AKH81181">
        <property type="protein sequence ID" value="AKH81181"/>
        <property type="gene ID" value="AA958_02220"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_02220"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.477"/>
    <dbReference type="OrthoDB" id="283831at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013457">
        <property type="entry name" value="Rhamnose_iso-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02635">
        <property type="entry name" value="RhaI_grampos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="70"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="385" mass="42225" checksum="1BB294EEE9D61519" modified="2015-07-22" version="1">MTVKAALKSQAVETPSWAYGNSGTRFKVFAQPGVPRTPQEKLDDAARVHEHTGVAPSVALHIPWDRVEGADGYAALAAYAKERGLRLGAINANVFQDDDYKLGSVTHPDPAVRRKALAHLMECVDIMDATGSRDLKLWFSDGTNYPGQDDLRERQDRLAEALAAVYERLGEGQRMLLEYKLFEPAFYHMDVPDWGTAYAHCLRLGDRAQVVVDTGHHAPGTNIEFIVAVLLREGKLGGFDFNSRFYADDDLMVGAADPFQLFRLMYEVVRGGGLGPGVAFMLDQCHNIEPKIPAIIRSVMNVQEATAKALLVDREALAAAQREGDVLAANAVLMDAYNTDVRPLLAEVREEMGLDPDPMAAYRRSGWAERIAAERVGGTQAGWGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-10-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0I5</accession>
    <name>A0A0F7N0I5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_00235</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH80854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH80854">
        <property type="protein sequence ID" value="AKH80854"/>
        <property type="gene ID" value="AA958_00235"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_00235"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.54"/>
    <dbReference type="OrthoDB" id="1180333at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="3">
        <location>
            <begin position="106"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH80854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="268" mass="29265" checksum="3A3E37A0C2AB3B26" modified="2015-07-22" version="1">MVPYAAMLDVPRHVVEYTARLLGAHRRRIGTRKGSRVLGPFRQAVFVLRWFREAACVHCLARDAGISQATGYRYLHEAIGVLAERAPNLHEVLADCRARGMSHVILDGTLISCDRVAGTTENGNDLWYSGKAKHFAGNIQFLAAPDGTPLWVSEVEPGSVHDLRAARLHALPALYPAARDGLPTLADIGYTGAGIGVHTPFRPHPDIPSPLAADTRTHNRLLRGIRALGERAAAELKQRWRALQHITLSPSRIGAIAKAALTLNNAWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0Q5</accession>
    <name>A0A0F7N0Q5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">[Acyl-carrier-protein] S-malonyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AA958_00725</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>holo-[ACP] + malonyl-CoA = CoA + malonyl-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:41792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="EC" id="2.3.1.39"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.1.39" evidence="2"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH80934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_00725"/>
    <dbReference type="EnsemblBacteria" id="AKH80934">
        <property type="protein sequence ID" value="AKH80934"/>
        <property type="gene ID" value="AA958_00725"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_00725"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.165"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004314">
        <property type="term" value="F:[acyl-carrier-protein] S-malonyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901362">
        <property type="term" value="P:organic cyclic compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004410">
        <property type="entry name" value="Malonyl_CoA-ACP_transAc_FabD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00128">
        <property type="entry name" value="fabD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="3 8" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="10">
        <location>
            <begin position="314"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="10">
        <location>
            <begin position="1853"/>
            <end position="1928"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="398"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1727"/>
            <end position="1751"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="2420"/>
            <end position="2449"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="8">
        <location>
            <position position="351"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="8">
        <location>
            <position position="1888"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AKH80934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="2463" mass="259656" checksum="E107773807117179" modified="2015-07-22" version="1">MGAQLFGRFPEEVARADEILGYSIEELCRDDVEGRLQNTEYTQPALFVVNALSHLAHRADGGAEPDYLAGHSLGEYNALHAAGAFDFATGLRLVAKRGELMSRVADGGMAAVVGLTAEQVAELLARPGLENLSIANYNNPTQIVVAGPRDDVAGARAVFEEAGAGLFTVLRVSGAFHSPYMSAIQGEFAEFLNKFTLAPPAVPVISNVTALPYEDDVAAALVRQLDHPVRWTDTVRYLIARGVADIKPIGPGRAMRGLIKATRRDEERRAEEAREAAAAEDAARIAVAPASGGELRLRRPERDRARPEGTPAVQLHQALLKDLRTTVAQVLKVEPAVVRSETELSELGFDSIRLIEFADLLRRDLGVDLTPSVFFEHFTLEAFARHLLTEHHDLVSARYPDAGDDAPRTGPRGAGRAQDDAPLPDPYPVAVVGLSAVLPGSADLEGFWQRLLAGDELVTKVPEDRWRDWAGAERAARAHGAFLDEVDSFDCSFFGISPHEAELMDPHQRLFLQTVWKAVEDSGRRPDTLAGSRTGLFVGLSSMDYAEVLGHSAAGPQAHTATGLSHAVLPNRVSYQLDLRGPSEAIDTACSSSLVAVHRAVRSLRTGECGLAIAGGVNLMLSPTPFECFELAGMLAPDGRCKTFDQSADGYVRGEGVVAVVLKPLAAAEADGDHIHAVIRGSAVGHSGRAASLTAPSPEAQADVIVDAWRAAGLDPATATHVETHGTGTSLGDPIEIEGLKQAFARLYAAWGHDAPAEPHITLGSVKTAIGHLEAAAGLAGLVTMVKALRYGKLPALRHFEKLNPYIRLDGSPFRIGDRAGDWPRRTAPEGPVPRRCGVSSFGFGGSNAHVVLEEYEREPAGGEAPSAPLLIPLSARTPDALRDYARELVRHLDLHAPAGGTADFALTALADTLQLGREPMAARLAVVAEDADELYDALVHFLRGEDQGDTWWSGQATGAADLSRALLAGPEGNTYLDALAAAGKAAALARLWAAGADFDWALLRGGRPVRRTSLPTYPFERRPIRPQDLVPHVLLTPGQARPALAAAPAPAALAAAPAPAALPSGAGAAQEAVLGHLVGLFAEELKWRPEEIDPRAGFDDLGLSSLLVEKLRRRLEEHYGPVDSATLFTYKNLDALARHMAGRVRTPPAATPAPAAVQPAAVQPAAVQPGAVQPAPVPPAAAGAGTADIAIVGISGRYPKAPTLADFWDRLLAGDDCVDEIPLDRPGYRRYAELAREKFGDQWPRWGGFLDDVDAFDPQFFHISPRDARLLDPQERLFLTTAWETLEDAGYTPASLADPELGDERGSVGVFAGVTYNNYQMFAGGDLDEGVWRIVGSQTFSVANRISHLLNLGGPSLTLDTACSSSLYAIHLAVAAIRRGECAMALAGGVNLSLHPSKYVMLAEAGFLAEDGRCRAFAEGGTGYVPAEAVGAVLLKPLGRALADGDRIHAVIKGSAVNSDGRTYGYGVPNPVAQAELVRAALADAGVDAGSIGYVEAHGTGTSLGDPIEVRGLTEAYADAAAPHRRDGRPACAIGSVKATMGHAEAAAGIAQVTKVVLQLRHGTLVPSLLHTPELNPNLDLDSTPFAVQRETAPWEPPVLPGTGGPVTGPRRAGVSSFGAGGVNVHLILEEAPARPAPAAAGAGRPLVFPLSARTPENLRAYAARMAAFLRTLPAEPGAGDPEVPRAADVAYTLQHGREPMEYRAAFAARTLAEAAERFARVAAGDDGDERISTGRRPGRSGAAPAVPADAAPEQAAALWAAGGDADWAARPTGGRRVSLPTYPFSQERYWLEPSATNPARPTAPAVPIPVPAPRTAPEAEDSAAAPAAREAAAAADLLASLAAAPASERHTALATRMQQTLGELLEFPPGSPPDRQRGFFELGMDSVMAVRLGNLLEEALGLVLYAGVVFDYPSIDELAAYLLDELSLDDAPAPAAPEPAAEAPESAPDSALQVVHYTAGWEPAAAPEGPASWLTGPVLVFDDDGALTERVRDRHSGAAPVVGVRPGEAYEVAGDGRTVRAGSAQDHAALLAGLDAPPVTVLHAWSDPRTALTSVFHLSQALLRQGLRAPVRLLRVAAHADGGPDPLAEAFGGFARSVDHENPRLVQQAVAVRADAGEEPAAALLRACEAELAADARADAEVRHDADGRRVRRLRELPAVAPDAPGGVAVRPGGTYVITGGGGGLGLLFAEHLARQARVNLLLVGRSPLTGERQEALERIRALGADVRYERADVSDRGDVEWILAAARNRWGSVHGVIHSAGVLRDGLLPNKTADEIDLVLAGKVDGAVHFDAETAADDLDFFMVFSSLAALAGNPGQVDYAFASRFLNAFSRRREELRAAGERSGASIALVWPFWREGGMRVDESTEGFVRRRLGLTPLENAVGVEAFDAALRHAAPEFGVVHAERDKLQRVLRIEPPAAESAARRPGAAAKAGGGKPATGKGDSTVEIELKGVLAELGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0Y9</accession>
    <name>A0A0F7N0Y9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_01565</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sbp family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_027744874.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_01565"/>
    <dbReference type="EnsemblBacteria" id="AKH81068">
        <property type="protein sequence ID" value="AKH81068"/>
        <property type="gene ID" value="AA958_01565"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_01565"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.344"/>
    <dbReference type="OrthoDB" id="1930757at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009709">
        <property type="entry name" value="DUF1290"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06947">
        <property type="entry name" value="DUF1290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018579">
        <property type="entry name" value="Sbp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1 2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR018579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH81068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="110" mass="11313" checksum="FDF2D77776AB955F" modified="2015-07-22" version="1">MIAVLGLVAGIVMGLVVQPVVPAGLEPYLPIAVVAALDAVFGALRAMLDGIFDDKVFVVSFLSNVVVAALIVFLGDKLGVGAQLSTGVVVVLGIRIFSNAAAIRRHVFQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N102</accession>
    <name>A0A0F7N102_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SpoU_methylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_01620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014442.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH81078">
        <property type="protein sequence ID" value="AKH81078"/>
        <property type="gene ID" value="AA958_01620"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_01620"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.356"/>
    <dbReference type="OrthoDB" id="1422015at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016423">
        <property type="term" value="F:tRNA (guanine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18091">
        <property type="entry name" value="SpoU-like_TRM3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045330">
        <property type="entry name" value="Trm3/TARBP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044748">
        <property type="entry name" value="Trm3/TARBP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12029">
        <property type="entry name" value="PTHR12029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SpoU_methylase" evidence="1">
        <location>
            <begin position="19"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="164" mass="18236" checksum="5DC9FD9481341E7B" modified="2015-07-22" version="1">MFDHIRHRPPATLAREREIVVACAPLRTRANLSSIVRTAGCCGITRVIACGNAKVDPDVTRDSTDHVTIEVRRTLPPVLKDLRTAGYRVVGLEQTTNSHNLHSFSFPRKTALAVGNERLGLTEEELKFVDDCVEIPVWGMPHSYNVATATAMALYEYCKQYPEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N119</accession>
    <name>A0A0F7N119_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_05215</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_05215"/>
    <dbReference type="EnsemblBacteria" id="AKH81696">
        <property type="protein sequence ID" value="AKH81696"/>
        <property type="gene ID" value="AA958_05215"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_05215"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1095"/>
    <dbReference type="OrthoDB" id="1975303at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046253">
        <property type="entry name" value="DUF6286"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19803">
        <property type="entry name" value="DUF6286"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6286" evidence="3">
        <location>
            <begin position="115"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH81696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="225" mass="23975" checksum="2A917BA178C10C92" modified="2015-07-22" version="1">MSGNDTKSWPDAGSAGTAAEPRPDEWRQSTSASGYAAGPDGGSADAAARFWSVRRVPAALTAAAATVGIGLLLYDVVAVRAERPAMRWRRRVADELAARPLDDAWVLAAAALAVLLGAWLLLLAVTPGLRGVLPMRHSAPDLRAGLDRRAASVVLRDRAMQISGVRSVRVSVGRRRVSARAESHFRELDDVRADLAAVLGDGIRELGLARRPELSVHVRRPTVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N175</accession>
    <name>A0A0F7N175_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8 10">Uracil-DNA glycosylase</fullName>
            <shortName evidence="8">UDG</shortName>
            <ecNumber evidence="4 8 10">3.2.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ung</name>
        <name evidence="12" type="ORF">AA958_02115</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 8 10">Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 10">
            <text>Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.</text>
            <dbReference type="EC" id="3.2.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8 10">Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.27" evidence="4 8 10"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014527.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_02115"/>
    <dbReference type="EnsemblBacteria" id="AKH81163">
        <property type="protein sequence ID" value="AKH81163"/>
        <property type="gene ID" value="AA958_02115"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_02115"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.455"/>
    <dbReference type="OrthoDB" id="1260295at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004844">
        <property type="term" value="F:uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd10027">
        <property type="entry name" value="UDG-F1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00148">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002043">
        <property type="entry name" value="UDG_fam1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018085">
        <property type="entry name" value="Ura-DNA_Glyclase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11264">
        <property type="entry name" value="PTHR11264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="SSF52141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00628">
        <property type="entry name" value="ung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00130">
        <property type="entry name" value="U_DNA_GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 8 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 8 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDG" evidence="11">
        <location>
            <begin position="53"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8 9">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AKH81163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="228" mass="24721" checksum="CB3813EA5E231987" modified="2015-07-22" version="1">MAGRPLPDIVEAGWAKALEPVAQQIAAMGDFLRAEVAAGRTYLPAGPNVLRAFQQPFDDVRVLIVGQDPYPTPGHAVGLSFSVAPDVRPLPGSLENIFRELHNDLGHPRPANGDLTPWTTQGVLLLNRALTTAPRRPAAHRGKGWEQVTEQAIQALAARGRPLVAILWGRDARNLRPMLSDYPAIESAHPSPMSADRGFFGSRPFSRANELLQKQGAEPVDWTLPTNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N1A4</accession>
    <name>A0A0F7N1A4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Methionine aminopeptidase</fullName>
            <shortName evidence="2">MAP</shortName>
            <shortName evidence="2">MetAP</shortName>
            <ecNumber evidence="2 3">3.4.11.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Peptidase M</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">map</name>
        <name evidence="5" type="ORF">AA958_05835</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 2">Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 3">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="2 3">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="2 3"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015154.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_05835"/>
    <dbReference type="EnsemblBacteria" id="AKH81801">
        <property type="protein sequence ID" value="AKH81801"/>
        <property type="gene ID" value="AA958_05835"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_05835"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1221"/>
    <dbReference type="OrthoDB" id="1285136at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070084">
        <property type="term" value="P:protein initiator methionine removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01086">
        <property type="entry name" value="MetAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01974">
        <property type="entry name" value="MetAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002467">
        <property type="entry name" value="Pept_M24A_MAP1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00500">
        <property type="entry name" value="met_pdase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M24" evidence="4">
        <location>
            <begin position="12"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH81801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="255" mass="26268" checksum="3B498F7C50F54CAC" modified="2015-07-22" version="1">MVEIKNDAALDAMREAGRVVAQALAAARDAAGVGVSLLELDEVAREVLDKAGAGSPFLGYRPSFASTPFPAVLCTSVNDAIVHGIPTAYRLRDGDLVSLDFGAELDGWTGDAAISFTVGTPRPQDTALIAATQRAIDAGVAAAVAGGRLGDISAAVGHVAAEAGCGMPADFGGHGIGRRMHEDPHVPNRGRAGRGFRLRHGLTLAIEPMLLSGGSDDYEVDGDGWTLRTTDGSRAAHIEHTIAVTDDGPRVLTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N1G1</accession>
    <name>A0A0F7N1G1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ROK family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_02765</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ROK (NagC/XylR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014636.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_02765"/>
    <dbReference type="EnsemblBacteria" id="AKH81273">
        <property type="protein sequence ID" value="AKH81273"/>
        <property type="gene ID" value="AA958_02765"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_02765"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.592"/>
    <dbReference type="OrthoDB" id="1130699at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="416" mass="42708" checksum="40A58B8799B25051" modified="2015-07-22" version="1">MARNNGRTVRDLRRSNRSAVLRHLYFEGPLSRQELGPVTGLSSGSISNVAAELIAEGVLEEAGAVDSDGGRPRTLLRVAPRCGHIAGVDVGETRVRVELFDLARTELARAERPLADGGRDAGRVVAHIAEGLAAVLADAGVAAGELLGVGLGVPGIVDREPARGGAVVYAQTIGWDAVPLEAMLRTAATGAPGLADVPYTVANGAKTLGQAEMWFGAGRGARNAVIALIGSGVGACVVTDGTAYGGSSSGAGEWGHTTMRIRGRRCRCGARGCLEAYVGAEGMLRRWREAGGEPVATDEESALAELIAADDPAARAVLDETAEYLGAGIADLVNLFNPERIVLSGWAGLLAGPRLLPAVRGATAMYALRYPAARAAIEMGELGTDAVTVGAATLPLSHFLDAGGTSHRDTAATPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N1H9</accession>
    <name>A0A0F7N1H9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Multidrug ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_06060</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015194.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_06060"/>
    <dbReference type="EnsemblBacteria" id="AKH81841">
        <property type="protein sequence ID" value="AKH81841"/>
        <property type="gene ID" value="AA958_06060"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_06060"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1266"/>
    <dbReference type="OrthoDB" id="1833499at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="3"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH81841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="311" mass="32729" checksum="CCB769E0320300E8" modified="2015-07-22" version="1">MTIEVRGLTKRYGEKTAVDDLTFTVRPGTVTGFLGPNGAGKSTTMRLIVGLDAPTSGSVTVNGRPYARHPAPLSEVGALLEARSVHTGRSAYKHLLALALTHGIPRARVEEVIEAVGLAGVARRRAGGFSLGMGQRLGIAAALLADPAAVVLDEPVNGLDPEGVLWIRNLLKELAAEGRTVFVSSHLMSEMALTAEHLVIVGRGRLLADTTVTEFVRAAGRDEVSLRSPQAGRLRELLAGPGVEVASDGPDELRVRGVGAEDIGLTAAAHGVPLFGLTPHRVSLEEAFMELTRDAVEYHAPTAGRKEEIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N1L1</accession>
    <name>A0A0F7N1L1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AA958_09720</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015803.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_09720"/>
    <dbReference type="EnsemblBacteria" id="AKH82460">
        <property type="protein sequence ID" value="AKH82460"/>
        <property type="gene ID" value="AA958_09720"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_09720"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2046"/>
    <dbReference type="OrthoDB" id="430372at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amoino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="194"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="237"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="276"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="315"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="370"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="395"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="435"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="462"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="AA_permease" evidence="8">
        <location>
            <begin position="52"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH82460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="492" mass="51034" checksum="7315544379DC61E0" modified="2015-07-22" version="1">MSTSPHPDGTAGAPVGAAADPAGIPAPATADAAAPAAGPVPSALGTGLKQRHLTMIALGGVIGAGLFVGSGAGIAAAGPGIVLAYAVSGLLVMLVMRMLGEMSAAHPASGSFSVHAERALGPWAGLTSGWMYWTLLGVAIAAEAIGASQIVTGWLPGTESWMWVLLFMAVFCVTNLAAVGNFGEAEFWFAGLKVAAITAFLALGLLAVLGLLPGTDSPGTANLTGGGDGFLPNGSEGLLVGLLASVFAYGGLENVTIAAAESEHPRRGVARAVRTAMYRIAIFYVGSMLVVVALLPWDDPAVKSGPYAAALDHLGIPAAGQVMNVVVLVALLSAMNANIYGASRMAYSLVARGQGPRFLGRLTHRVPRRATVATCSFGFAAVLLSYRWPDTLFQWLLNMVGAAILVVWAFTAVAQLRTRRRLEREAPELLTVRMWAYPYLTWAALAAMAGILVLMLREPDSRTQLLTTAGLTAALSLVGLVRQHRRRGTRMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N1T9</accession>
    <name>A0A0F7N1T9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">XRE family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_03140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018836716.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_03140"/>
    <dbReference type="EnsemblBacteria" id="AKH81339">
        <property type="protein sequence ID" value="AKH81339"/>
        <property type="gene ID" value="AA958_03140"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_03140"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.669"/>
    <dbReference type="OrthoDB" id="1933795at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16837">
        <property type="entry name" value="BldD_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038099">
        <property type="entry name" value="BldD-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037664">
        <property type="entry name" value="BldD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="13"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="167" mass="18130" checksum="A4B3A27981207670" modified="2015-07-22" version="1">MSSEYAKQLGAKLRGIRTQQGLSLHGVEEKSQGRWKAVVVGSYERGDRAVTVQRLAELADFYGVPVQELLPGSAPGGAAEPPPKLVLDLERLAQIPAEKAGPLQRYAATIQSQRGDYNGKVLSIRQDDLRTLAVIYDQSPSVLTEQLIGWGVLDADARRAVVVHEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N269</accession>
    <name>A0A0F7N269_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">LacI family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_03990</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014844.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_03990"/>
    <dbReference type="EnsemblBacteria" id="AKH81488">
        <property type="protein sequence ID" value="AKH81488"/>
        <property type="gene ID" value="AA958_03990"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_03990"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.837"/>
    <dbReference type="OrthoDB" id="664909at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="5">
        <location>
            <begin position="35"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH81488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="366" mass="36679" checksum="FCC9401048BAA55E" modified="2015-07-22" version="1">MRGAHEDGRRAAARTGPPAAGEPAPRPAAGRGGGVTSRDVARAAGVSQAAVSLVLGGKWRGRVSAAKADAVRAAARELDYRPNAAARTLRTGGTRTALLVVPALTNEFFAGVHAGAARAAAAHDFGVVLYPSPEGIGPARDPFAAAHTAVDGVIASSMATDAVRNLRGGGLPLVMLDSDPAGTGAVATVNADVADGMRQVARHLLELGHRRITRLAAAIDSWTFTARGRALAEALGAVPAVRLCTEPAELSVAGGLAAAQRALTAPAADRPTALVCDDDLLAAGALKAVRRLGLRVPYDVSVTGFDDLALATAVEPELTTVRLPADSVGAAGMTALLDALAGRGAGSTTVPARLTVRASTAPAPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N279</accession>
    <name>A0A0F7N279_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_07555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015461.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_07555"/>
    <dbReference type="EnsemblBacteria" id="AKH82111">
        <property type="protein sequence ID" value="AKH82111"/>
        <property type="gene ID" value="AA958_07555"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_07555"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1583"/>
    <dbReference type="OrthoDB" id="13828at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045725">
        <property type="entry name" value="DUF6079"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19557">
        <property type="entry name" value="DUF6079"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1210"/>
            <end position="1259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="1287" mass="141542" checksum="65125639295CF5B2" modified="2015-07-22" version="1">MAANPANGNTGTPLLRELINIKPEVSSSDYVLQLADATTPDGAAKALAEYVVTDDLVKHFNEALGIIKAAVDSHSSKAAYLHASFGAGKSHFMAVLHALLNKAPAARGRTDFDPVFAKNRWLQDGDRRFLMVPVHMLDAKSMEQRILGGYVKRIKELEPGAPTPRVYRTDAMFRDLQSMRERLGDEDVIKFLAGAASAEAEADGDGGEWGEFGAAFAWTTELLDQAMAAEELEVGQEFNPADPSTPGELRARLAQDTAKVLPGYEERAVEQDGGFISLDRGLSVIAQHAKSLNYDGIVLFLDELILWFASRISESEFVSRETAKITNLVESGDERRAIPVVSFIARQRDLRDLVGSAEDGGRYQRAIVDNLELASGRFDRISLEDRNLPQIAHARLLKPDTTEKAAVIEEAFKKAKSTNAKFWDELLGGDGNNVGATETAFRFTYPFSPAFMDTLVHLSSALQRSRTGLKLMGELLAHRRNLLRVGELVPLGDIYALISGGGDKPFTDELRAVFEEADRLYRNRMRPYLLDQHRVTEEQVATYQQDPAAVEDGDLSRRLKQFTDDDRLMSTLVLSALAPAAPAFQNMTVKRLLALNAGTIKALLPGGEIPALINKLKEWAGRIPEIKLAGDGVAMTVRLELSGVDIDSVVRNGREAFDKPRYRHDAAVELLRSEFALTAAKGQGGFDAYDTLDFTWRGSKRRTEVVFANIADREETPYSTLTPTDTETWRLVIDLPWDEGAYGPREDVNRMNGFWERHPEVQHSLAWVPTHMTTTMYGDFNRYVVIKRILNSGGDFDSRFAAHLGPDDRVRARGLLSTQADTLRDRVVAAFRQAYGLAKKQEGDVLDDFSDHIATKPGVTTPALALGAAPRDAIREIAGRVLAWQYPGHPDLGAEAVTPAQARTVLGYVSEAARAKEGKAEVVPRGERELMETVAQPLKLGTMGESYFTLGTYWREHFNRLAKNDPDADIGYGMLTAWMDEPQRMGLATHVQQLVAAAYGEMEDRVWVIGGAPVADLKLGEIKDGWALRRQPLPSAPDWETARARYEKIFGKKAPVQLRGRIVNSFADLVRTHVDKLLPANRELVAELERRADFLGLDDTAVNGRLHTARRGLALLEELLAEKGRGAKRVVEALAAFGLGELTPERLGSSVTTADVVAPALQNASWDVLELGTGMDALTTLQEDAREDQFSRKLQDSLPRAQRAITQALAVQRQQQRTEPPADTADTPASPSPDQVPLTTDTSHPKVDTTARTGSLQGSAAEVEQALHQVAAAHPGKGIEITWKVVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N292</accession>
    <name>A0A0F7N292_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycerol kinase</fullName>
            <ecNumber evidence="5">2.7.1.30</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ATP:glycerol 3-phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Glycerokinase</fullName>
            <shortName evidence="5">GK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">glpK</name>
        <name evidence="9" type="ORF">AA958_04075</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + glycerol = ADP + H(+) + sn-glycerol 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:21644"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.30"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="5">Inhibited by fructose 1,6-bisphosphate (FBP).</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the FGGY kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.30" evidence="5"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014859.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_04075"/>
    <dbReference type="EnsemblBacteria" id="AKH81504">
        <property type="protein sequence ID" value="AKH81504"/>
        <property type="gene ID" value="AA958_04075"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_04075"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.856"/>
    <dbReference type="OrthoDB" id="233605at2"/>
    <dbReference type="UniPathway" id="UPA00618">
        <property type="reaction ID" value="UER00672"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004370">
        <property type="term" value="F:glycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006072">
        <property type="term" value="P:glycerol-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00186">
        <property type="entry name" value="Glycerol_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018483">
        <property type="entry name" value="Carb_kinase_FGGY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005999">
        <property type="entry name" value="Glycerol_kin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01311">
        <property type="entry name" value="glycerol_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00445">
        <property type="entry name" value="FGGY_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="5 6 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FGGY_N" evidence="7">
        <location>
            <begin position="11"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="FGGY_C" evidence="8">
        <location>
            <begin position="267"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="88"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="251"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="18"/>
            <end position="20"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="321"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="418"/>
            <end position="422"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH81504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="508" mass="54979" checksum="1AABEB555D3F3A0B" modified="2015-07-22" version="1">MTDAHTAGPFIAAIDQGTTSSRCIVFDTDGRIVSVDQKEHEQIFPKPGWVEHNATEIWRNVQQVVDGAVAKAGITRTDVKAIGITNQRETTLLWDKHTGEPVANAIVWQDTRTAELCRQLGGTQGQDRFRAATGLPLASYFAGPKIRWLLDNTPGLLARAEAGDILFGTMDSWVIWNLTGGPGRGVHVTDVTNASRTMLMNLETLDWDPAICEAMGVPLAVLPQIRSSAEVYGHAASGTLTGIPVASALGDQQAALFGQTCFDQGEAKSTYGTGTFLLMNTAGEPVHSENGLITTVGYRIGDQSAVYALEGSIAITGALVQWMRDQMGIISTAAEIETLALSVEDNGGAYFVPAFSGLFAPYWRDDARGVIAGLTRYVTKAHLARAVLEATAWQTREIVDAMTKDSGVELTSLKVDGGMTANNLLMQTLADVLDAPVVRPLVAETTCLGAAYAAGLAVGYWPDTDALRANWRRAAEWTPRMDETTREREYKDWLKAVQRTMGWIEDKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2A2</accession>
    <name>A0A0F7N2A2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_07705</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GTP cyclohydrolase I type 2/NIF3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015486.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_07705"/>
    <dbReference type="EnsemblBacteria" id="AKH82136">
        <property type="protein sequence ID" value="AKH82136"/>
        <property type="gene ID" value="AA958_07705"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_07705"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1619"/>
    <dbReference type="OrthoDB" id="502462at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002678">
        <property type="entry name" value="DUF34/NIF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036069">
        <property type="entry name" value="DUF34/NIF3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13799">
        <property type="entry name" value="PTHR13799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01784">
        <property type="entry name" value="NIF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102705">
        <property type="entry name" value="SSF102705"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00486">
        <property type="entry name" value="YbgI_SA1388"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="276"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="287"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH82136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="313" mass="32393" checksum="9261769EBCFC2990" modified="2015-07-22" version="1">MPALADVVAALEALWPAGRAEPWDAVGTVCGDPDARVERVLFAVDPVREVVDEAVEWSADLLVTHHPLYLRGTSTVSAGTFKGRVVHTLIKNDVALHVAHTNADRADPGVSDALAGALGLRVTGPLVPDADDPAGRRGLGRLGELDAPVPLREFADRAAAALPRTATGLRVAGDPEGEVRTAAVCGGSGDGLFDAVRAAGVDVYVTADLRHHPVSEAQQHAALAAGGRPYLIDAGHWASEWPWCEQAAAQLDAISDRNAWGLRTRVSRIVTDPWTTHAPAPAARSTSAAPSAGTAGSPASHASLAPTSPEQPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2N2</accession>
    <name>A0A0F7N2N2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NB-ARC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_04945</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015004.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_04945"/>
    <dbReference type="EnsemblBacteria" id="AKH81649">
        <property type="protein sequence ID" value="AKH81649"/>
        <property type="gene ID" value="AA958_04945"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_04945"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1040"/>
    <dbReference type="OrthoDB" id="622851at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="NB-ARC" evidence="3">
        <location>
            <begin position="40"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="509"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="679"/>
            <end position="768"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH81649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="768" mass="79418" checksum="E1472A0EB91E912D" modified="2015-07-22" version="1">MTEQAAPHRFVGRTRELDSLRADIARAGLDTLAGRPAPRGRVLLIAGRPGSGRSALAAELARGVAGDYPGGVHTARLSGPGGVAVPLERAVRDLLDALGVPPVAGAGPDHLAAELRAALAERSTVLVLDDVTAPEQLLALVPESRDCLVVAVAEGPLKGVPDVRPCTLGGLEPTAALALIATYAGETRIACDPEATHVLAEECAGHPAALVLAGGWLAGHPQACVADAVRELRRKGDSTEGSAGRPSGPKALARAFRLVYESLPPSVAQLLRLLPLAPVGVVDAHSASALAGCTVAAARTTLADCAGQGLLREVPEPDRANLTQYEVPGCLQPLLRGVLEAGVGREEMLFARARMLERYVRLLQSCRAVTEPPGSAVHTRLGGLPRALRFPSPEAAAAWLGSRLPSLLAAARIAVADGELDTLARRLVAALSRALAAHRGEAEAAPEQYRLHELVLGVAERRGLVWEKAAALLNLGDLDLRAERPHEALGRYRGALAAAREVRDPQPVGRALESVGAAYQELRDWGRAADWFGRALALRQTRGELADEARLRARLGAVHTYAGAWGWALREWRAAAAAHRRLGDVGGHARALGEVARVQQYAGYPREAIRTCTRAVDVARLSGDTALRTAVQLRLADLVDGAGDPEAAELHRAAAGRLAEQVPEAAAVRAAAVAVAEAEAERADDPGPAPVAGSAAEPVPEPAAGPQHGDAPGDGERGTGSAAVPEDPAEPVPQPVEAAAGTVPAEGSEPAGEGPKAGPAPRPAAADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-08-12" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N346</accession>
    <name>A0A0F7N346_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative_PNPOx domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_02815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014645.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH81282">
        <property type="protein sequence ID" value="AKH81282"/>
        <property type="gene ID" value="AA958_02815"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_02815"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.602"/>
    <dbReference type="OrthoDB" id="1804797at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="1">
        <location>
            <begin position="29"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="184" mass="19527" checksum="9D328BAA80B0E31F" modified="2015-07-22" version="1">MTEATAHQPETTLDAAFSGAGAAATPWPDARRELETAATFWLTSVRPEGRPHVTPLIGVWLDGAVYFGTGAEERKARNLAANPHCIVSTGGSALDEGLDVVVEGDAAQVRDRALLGRVADAYTAKYGRHVTSPEGTFHGLPEAIRRGEGPLVFEVTPRVAFAFAKGEPFGQTRYRFPARAPGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3A2</accession>
    <name>A0A0F7N3A2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 2">Virginiamycin B lyase</fullName>
            <ecNumber evidence="1 2">4.2.99.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1 2">Streptogramin B lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">vgb</name>
        <name evidence="3" type="ORF">AA958_09940</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 2">Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1 2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the Vgb family.</text>
    </comment>
    <dbReference type="EC" id="4.2.99.-" evidence="1 2"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015843.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_09940"/>
    <dbReference type="EnsemblBacteria" id="AKH82501">
        <property type="protein sequence ID" value="AKH82501"/>
        <property type="gene ID" value="AA958_09940"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_09940"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2093"/>
    <dbReference type="OrthoDB" id="966287at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016835">
        <property type="term" value="F:carbon-oxygen lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017001">
        <property type="term" value="P:antibiotic catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01282">
        <property type="entry name" value="VirginiamycinB_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011217">
        <property type="entry name" value="Streptogrm_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026412">
        <property type="entry name" value="Streptogrm_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="1 2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="1 2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1 2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="273"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR026412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH82501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="297" mass="31147" checksum="E7F7E4872D1FA266" modified="2015-07-22" version="1">MHPSAAPAIREIPVADRDAGPYGIATGPDGALWLTFAHSGRIARLTLDGELDEYALDSSECRPAVITPGPDEALWFTRSRDHRIGRITVDGETESFPVPTPDSGPFGIAAGPDGAMWFTEMNTDRIGRITCEGEITEFALPRTGAYPSAISAGPDGALWFTLNQANAIGRITVDGDFATHPLPTPGAAPVGIASDGAALWFVEIAAGQIGRIPVDGEIEEFPLPDRTAKPHAIVAAATGDCWFTEWGANRIGRITDGGEIAEYALPSPSSEPHGITVGSDGALWVALETGGVARLEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3B0</accession>
    <name>A0A0F7N3B0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_06105</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015202.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_06105"/>
    <dbReference type="EnsemblBacteria" id="AKH81849">
        <property type="protein sequence ID" value="AKH81849"/>
        <property type="gene ID" value="AA958_06105"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_06105"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1275"/>
    <dbReference type="OrthoDB" id="1619224at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="133"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="189"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="237"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="297"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="101"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH81849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="330" mass="36107" checksum="C880FA97EFD5FEF1" modified="2015-07-22" version="1">MKDSLAAEVALAPPTEPSRPGRASADAARRRKRLVTVTRPWLLLAPSLVVLAGLLLWPLIEVGKLSLQDYEVKFGGGVGTWTGFDNYSALLSNELLWRTVLPNTAFFAFGCVILTVAFGTFVALLLNRLGTVWRVVCSTAIMAAWAMPAVTGTYVWVWLFAAEDGLMSRLAGGLGLIDPETTNWFTERLGFYAIATLNVVHHGFPFVAITVLAGLMTVPKELYEAGMIDGASAWQRFWRITVPALRPIFLVVTILSTIWDFKVFTQIFLMPGGSGSNEDVMNLGVYSYIEAFAKNDYGAGAAAAVMLTLLLIAITLVYIRTLFRQGEEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3D1</accession>
    <name>A0A0F7N3D1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Xylose isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_10255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015888.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_10255"/>
    <dbReference type="EnsemblBacteria" id="AKH82546">
        <property type="protein sequence ID" value="AKH82546"/>
        <property type="gene ID" value="AA958_10255"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_10255"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2161"/>
    <dbReference type="OrthoDB" id="1007505at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="22"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="265" mass="28265" checksum="B6DA68A66DB3549A" modified="2015-07-22" version="1">MRLAFSTLGMPQLPVAEVARCARDGGYQGVELRCHPEEPVHTGLGIGERADVVEEFAAAGVEILTVAGYAGVAAAGDDEPVVTEMRELLALARDLGAAHVRVFPRGGEQPAVEADPTAARRLAAVAPYAADLGVRVLLETHDSHRTGADVARILDGVGHKSTGALWDVMQTWLGGEEPQESFAALSPYLGYVQVKDTASREELAPLALGEGTVPLAECLAVLTEAGWDGWLCWEYEKRWFPEARELAPLLAGGREHLLQLLADVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3G1</accession>
    <name>A0A0F7N3G1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pyridoxal phosphate homeostasis protein</fullName>
            <shortName evidence="1">PLP homeostasis protein</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_06510</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015271.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_06510"/>
    <dbReference type="EnsemblBacteria" id="AKH81919">
        <property type="protein sequence ID" value="AKH81919"/>
        <property type="gene ID" value="AA958_06510"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_06510"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1359"/>
    <dbReference type="OrthoDB" id="1423012at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02087">
        <property type="entry name" value="PLP_homeostasis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011078">
        <property type="entry name" value="PyrdxlP_homeostasis"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10146">
        <property type="entry name" value="PTHR10146"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004848">
        <property type="entry name" value="YBL036c_PLPDEIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00044">
        <property type="entry name" value="TIGR00044"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01211">
        <property type="entry name" value="UPF0001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ala_racemase_N" evidence="4">
        <location>
            <begin position="25"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="1 2">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR004848-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH81919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="265" mass="27270" checksum="28B1D75C9882B7CB" modified="2015-07-22" version="1">MADFTGDGGVQEAADRERRGELAANLAAVEERIAGACAAAGRKREEVTLVVVTKTYPASDVLLLADLGVRHVAENRDQEAAGKAAWCAERGADAPLTWHFVGQLQTNKARSVARYADYVHSVDRPRLVTALAAAAEREGRELGCLLQVALDKDAAPGTDSGGGATADRGGVAPGDVPALADAVAAAQGLRLCGLMTVAPLAGAYAGRQRAAFERLMEISSGLRVAHPAATMVSAGMSGDLEEAIAAGATHVRVGTAVLGVRPQLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3I2</accession>
    <name>A0A0F7N3I2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Histidine--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Histidyl-tRNA synthetase</fullName>
            <shortName evidence="8">HisRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">hisS</name>
        <name evidence="10" type="ORF">AA958_03245</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-histidine + tRNA(His) = AMP + diphosphate + H(+) + L-histidyl-tRNA(His)</text>
            <dbReference type="Rhea" id="RHEA:17313"/>
            <dbReference type="Rhea" id="RHEA-COMP:9665"/>
            <dbReference type="Rhea" id="RHEA-COMP:9689"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78527"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.21"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.21" evidence="8"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014716.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_03245"/>
    <dbReference type="EnsemblBacteria" id="AKH81357">
        <property type="protein sequence ID" value="AKH81357"/>
        <property type="gene ID" value="AA958_03245"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_03245"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.691"/>
    <dbReference type="OrthoDB" id="277998at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004821">
        <property type="term" value="F:histidine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006427">
        <property type="term" value="P:histidyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00773">
        <property type="entry name" value="HisRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00859">
        <property type="entry name" value="HisRS_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00127">
        <property type="entry name" value="His_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015807">
        <property type="entry name" value="His-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041715">
        <property type="entry name" value="HisRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004516">
        <property type="entry name" value="HisRS/HisZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033656">
        <property type="entry name" value="HisRS_anticodon"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43707">
        <property type="entry name" value="PTHR43707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13393">
        <property type="entry name" value="tRNA-synt_His"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001549">
        <property type="entry name" value="His-tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00442">
        <property type="entry name" value="hisS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="9">
        <location>
            <begin position="31"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AKH81357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="428" mass="46357" checksum="42A4A38F89DF07C1" modified="2015-07-22" version="1">MTTPSVSTSPAFKAPKGTYDLIPPRSAAYLAVREAFAAPVRRAGYGYVETPGFEDVRLFARGVGESTDIVTKEMYTLTTKGGDELALRPEGTASVLRAALESNLHKQGNLPVKLWYSGSYYRYERPQKGRYRHFSQVGAEAIGAEDPALDAELIVLAVDGYRALGLTGFRLLLNSLGDQECRPAYRTALQDFLRGLDLDEPTRERIEINPLRVLDDKRPEVRTQLDAAPLMRDHLCEACKAYHEQVRELLTAAGVAYEDDPRLVRGLDYYTRTTFEFVHDGLGAQSAIGGGGRYDGLSEMIGGPALPSVGWALGVDRTVLALEAEGVALDLPATTDVYAAALGEQARRTLFGVVTELRRAGIAADFAFGGKGLKNAMKSADRSGARFALVAGERDLDEGVVQLKDLGSGEQRAVGLAEVVGELRKLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3J9</accession>
    <name>A0A0F7N3J9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cell division protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_06560</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015280.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_06560"/>
    <dbReference type="EnsemblBacteria" id="AKH81928">
        <property type="protein sequence ID" value="AKH81928"/>
        <property type="gene ID" value="AA958_06560"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_06560"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1369"/>
    <dbReference type="OrthoDB" id="213680at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005311">
        <property type="entry name" value="PBP_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036138">
        <property type="entry name" value="PBP_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03717">
        <property type="entry name" value="PBP_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56519">
        <property type="entry name" value="SSF56519"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PBP_dimer" evidence="4">
        <location>
            <begin position="113"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="3">
        <location>
            <begin position="323"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="516"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="648"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="10"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH81928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="683" mass="71803" checksum="A9D29D1566FFF27B" modified="2015-07-22" version="1">MTTRDSGGSSRDGGDGRDARRRVPRPASGGRGGAARPRSRTRASTPGPRPPRPAGGGPRIRLASPRPRLRLVSVGLTLLLLVFTARLLQVQAVDAGEYAEKAQVNRYVPMTLSAERGVITDRNGVELATTVDAYDITADPYLFTPEQADVKDAPRRAAEALAPVLKADAKDLEAKLATPGSRYVKLASKQTPQVWDEIKKLKSESAGREAAGGRQDVLGGVFAEEQNKRVYPNGDLAAGILGFVNAEGEGGGGVERQHDKLLAGKDGRLVYAQSAGRRIPTADAEENPAEPGSDVELTIDRDIQWAAQTAIEKQVDASEADRGYVIVQDTRSGEILAMANAPGFDPNDLSGATPGTLGNPALEDAYEPGSVNKVISMAAVLEEEAATPDTRVTVPNVLPRGGHAFHDDVEHPTWYLTLNGVLAKSSNIGTILAVEQLGKNQRQANKVLHSYLSDFGLGRRSGLGVAGETPGLLKPAAEWDAAQQYTIPFGQGLSVNALQAASVYSTVANGGVRIEPSLVRGSRGPDGRFDPAPEPEKNRVVSQKTARTLSRMLESVVDDEEGTGVKARIPGYRAAGKTGTSNRVDPQTGRYNGYTASFAGFAPADAPRVTVYCAIQNPTEGSYFGGQICGPVYKKVMEFALKTLQVPPTGVEPPPMPVTFGAGTDGTGGDGEGTDAGGVADGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-10-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3M2</accession>
    <name>A0A0F7N3M2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_14715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH83270">
        <property type="protein sequence ID" value="AKH83270"/>
        <property type="gene ID" value="AA958_14715"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_14715"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3098"/>
    <dbReference type="OrthoDB" id="1002931at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="308" mass="35020" checksum="2C07099B6126DC3F" modified="2015-07-22" version="1">MGLGPKFNKTVPGQVVDRFTGMNKTLGFPAVPTPDLGDDDDGPSDATRLLCAAAHLRPEWDKQIKSKLRQGWRGIVRQIAPRWIKELLQERDEKAKLSQAETLADGTKKDPQKIVPLGLDYARWVHCRVLAKELRPVPSHGFDLAEVALSCAQAIRLGRQRRVLMLMAWIVAGLCWWRIGVDWALLTLLVGIWAVCLSDRLVSQRLLRDVMAREADGGRSPQRLSAAHDGAVQRMHGMEGQPVIPYEQQIRPGQVRYHFLGAGKPWYERNIGIDVMAPTRQWDSLHRSSHCLRSCNRRRCQFVEERFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-08-12" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3Q2</accession>
    <name>A0A0F7N3Q2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_06990</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015355.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH82004">
        <property type="protein sequence ID" value="AKH82004"/>
        <property type="gene ID" value="AA958_06990"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_06990"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1462"/>
    <dbReference type="OrthoDB" id="1654295at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013196">
        <property type="entry name" value="HTH_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028349">
        <property type="entry name" value="PafC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026881">
        <property type="entry name" value="WYL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08279">
        <property type="entry name" value="HTH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13280">
        <property type="entry name" value="WYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016838">
        <property type="entry name" value="PafC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519210" evidence="3">
        <location>
            <begin position="22"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="HTH deoR-type" evidence="4">
        <location>
            <begin position="2"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH82004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="331" mass="35798" checksum="45F034297A317EB3" modified="2015-07-22" version="1">MRAARLIHLVLLLQSRPSMTAAELAERLEVSERTVARDVQALGEAGVPVYADRGRTGGYRLVGGYRTRLTGLGRTEAEALFLSGVPGALRDMGLADAASAARLKVSAALLPELRGAPESAAQRFHLDAPGWWREPDVPELLPAVAEAVWADRTLAVTYRRRPAAEAVEREVEPYGLVLKAGVWYLVARVPGAGGAYRVYRVERFERAAAVGGGAGFERDEEFDLPGFWTERAAAFARSILRDEVTLRLSPDGLRRLPHVTDRLAAEDAVAGAGEPDEQGWRAVRLRVESADVAYTQLLALGPDAELLGPPELRARFAAAAARSAALYGRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3V6</accession>
    <name>A0A0F7N3V6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alpha-N-acetylglucosaminidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_07145</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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    </dbReference>
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    <dbReference type="PATRIC" id="fig|444103.5.peg.1497"/>
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            <end position="1039"/>
        </location>
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        <location>
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            <end position="127"/>
        </location>
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        <location>
            <begin position="141"/>
            <end position="462"/>
        </location>
    </feature>
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        <location>
            <begin position="470"/>
            <end position="736"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH82033.1"/>
        </source>
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        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
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</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N477</accession>
    <name>A0A0F7N477_9ACTN</name>
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    <organism evidence="1 2">
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        <lineage>
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            <taxon>Actinobacteria</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH82174">
        <property type="protein sequence ID" value="AKH82174"/>
        <property type="gene ID" value="AA958_07940"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_07940"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1672"/>
    <dbReference type="OrthoDB" id="1742102at2"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH82174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="170" mass="17700" checksum="407980D73FBFDC32" modified="2015-07-22" version="1">MMDTTPLRDAYRALLNAATTVAESGDTSPAPPAGEWNADQILAHVALVNAATITAVSSAATGATTTYDNRTAQDTWTLDRVITLAGGNAGLRDRIRLQADALCALGGPMLSETELDTLVPALLLSNGKVLVDQPVPLRDLITGLAEVELPGHTQQLLALLPEDCGTQATT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4T5</accession>
    <name>A0A0F7N4T5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_09430</name>
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    <organism evidence="2 3">
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        <lineage>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015758.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_09430"/>
    <dbReference type="EnsemblBacteria" id="AKH82413">
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        <property type="gene ID" value="AA958_09430"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_09430"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1991"/>
    <dbReference type="OrthoDB" id="1458856at2"/>
    <dbReference type="Proteomes" id="UP000034283">
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="253" mass="27244" checksum="53D0298B4B8DAAE2" modified="2015-07-22" version="1">MDVVVALLALFFVLCVAAGVVLTVKATRAVKRGVERTVADTRRTVQETTLRARRAVQPGAAGDIAGLRLSLRNSIDATRRELEHAVQGDPGLRESIGLLDRLHEYARQVDGELRHLEREPDKSRIAERLPELRGRAERIAQSANSLRWAAQDRARHTAQDEDGLDALTTQIDLETGALRHWTPADGQETTAPGAASSEGPSKAAPGETARPADGAGRSPKQQPALSSGGTTEGQDAFQALLSKIEKMRKPESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4U9</accession>
    <name>A0A0F7N4U9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-nitropropane dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_09345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_09345"/>
    <dbReference type="EnsemblBacteria" id="AKH82399">
        <property type="protein sequence ID" value="AKH82399"/>
        <property type="gene ID" value="AA958_09345"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_09345"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1972"/>
    <dbReference type="OrthoDB" id="275153at2"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
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        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NMO" evidence="1">
        <location>
            <begin position="5"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="364" mass="37541" checksum="D487A036656B7F6D" modified="2015-07-22" version="1">MPTELNDLFTFPIVQAPMAGGASCPQLAAGVLEGGGLAFLAAGYKTPEAMYEEIRQLRAVTDRPFGVNLFMPQPPSPPDPAQIEAYAEQLAGEVEWYDTALGDAEAGTDDAFDAKVAILLDEPVALVSFTFGCPEAAVLDAFARAGTYTVVTVTNVVEARRAQAAGAGAVCVQGVEAGGHQGGFRNDPRDDDVGRGLLTLLAEVLEAVDVPVIAAGGLMRGGQIAAVLSAGAAAAQLGTAFLVCPESGANALHKRAVTGGVFTRTELTRAFSGRPARGLVNRFVREHGPYAPAAYPQVHHLTSPLRAAAARVGDPQGMALWAGQGYRLARELPAAELVEVLARELADALSGTTKPAGDASGGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-08-12" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4V6</accession>
    <name>A0A0F7N4V6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F420-dependent protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_17400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016994.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH83690">
        <property type="protein sequence ID" value="AKH83690"/>
        <property type="gene ID" value="AA958_17400"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_17400"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3660"/>
    <dbReference type="OrthoDB" id="1804797at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019967">
        <property type="entry name" value="F420-dep_enz_PPOX_Rv0121"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03668">
        <property type="entry name" value="Rv0121_F420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="1">
        <location>
            <begin position="9"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="146" mass="16007" checksum="35EDB44A2370E1D7" modified="2015-07-22" version="1">MNLSAVEARDRFIGSPVARLATADGAGVPHVVPITFAVDGDVIVFAVDHKPKRTTGLRRLRNIAENPAVSVIADHYADDWASLWWARADGRAEIRQDDAGRLPAVELLQQKYRQYEEAPPPGAVVVIHVVTWTGWAFTDDTKGPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4W2</accession>
    <name>A0A0F7N4W2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_13310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016377.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH83046">
        <property type="protein sequence ID" value="AKH83046"/>
        <property type="gene ID" value="AA958_13310"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_13310"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2800"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="128" mass="13243" checksum="DA878EFD4DE79420" modified="2015-07-22" version="1">MSLGEPPLLSRPPWVGVTTTLGQMAYALGALPAALMALMIPLFRGEREYCGPPDHTGPCDRIQEMSAASAAGLGLGVLTLLVAGAVAQSVGRRLAETGRERRGVALVLGMLAVPAVTYAMLAYGYTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4X1</accession>
    <name>A0A0F7N4X1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">6-phospho-beta-glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_13380</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
        <text evidence="6">Binds 1 NAD(+) per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyl hydrolase 4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016387.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_13380"/>
    <dbReference type="EnsemblBacteria" id="AKH83056">
        <property type="protein sequence ID" value="AKH83056"/>
        <property type="gene ID" value="AA958_13380"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_13380"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2814"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019802">
        <property type="entry name" value="GlycHydrolase_4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001088">
        <property type="entry name" value="Glyco_hydro_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022616">
        <property type="entry name" value="Glyco_hydro_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32092">
        <property type="entry name" value="PTHR32092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02056">
        <property type="entry name" value="Glyco_hydro_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11975">
        <property type="entry name" value="Glyco_hydro_4C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00732">
        <property type="entry name" value="GLHYDRLASE4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="SSF56327"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01324">
        <property type="entry name" value="GLYCOSYL_HYDROL_F4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_4C" evidence="7">
        <location>
            <begin position="196"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF11975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH83056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="443" mass="47612" checksum="B40C0F57AF83633E" modified="2015-07-22" version="1">MRLTVLGGGGFRVPLVFRALLEDSGDESGRCTEFVLYDTEPRRLEAIGAVLAQHAADGEARGARPPAVRTTTDLDDALRDTDFVFSAIRAGGLEGRSRDERAALTEGLLGQETVGAGGVLYGLRSVPAAMHIAERVAAVAPNAWVINFTNPAGMVTEAMQRLLGDRVIGICDSPVGMARRAARALGVDPDRTELDYVGLNHLGWLRRILVDGEDRLPALLADPATLESFEEGKLFGAEWLQALGSLPNEYLHYYYFNREAIAALRDAPATRGEFLREQQAAFYAAAAADPGEAAAVWECTRKEREATYMAESRESTGGWQRDTCDLDGGGYDRVALALMRAISRDEHATLILNVPNRTTIPGLDAEAVIEVPCRVDAQGAHPFPTRPAAADQLGLMLTLKDVERATIAAADTGSRAKALRAVALHPLVDSVNAADRILASRGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4Y6</accession>
    <name>A0A0F7N4Y6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Penicillin-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_09595</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015783.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_09595"/>
    <dbReference type="EnsemblBacteria" id="AKH82439">
        <property type="protein sequence ID" value="AKH82439"/>
        <property type="gene ID" value="AA958_09595"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_09595"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2022"/>
    <dbReference type="OrthoDB" id="423699at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009002">
        <property type="term" value="F:serine-type D-Ala-D-Ala carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005311">
        <property type="entry name" value="PBP_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036138">
        <property type="entry name" value="PBP_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017790">
        <property type="entry name" value="Penicillin-binding_protein_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03717">
        <property type="entry name" value="PBP_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56519">
        <property type="entry name" value="SSF56519"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03423">
        <property type="entry name" value="pbp2_mrdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="PBP_dimer" evidence="4">
        <location>
            <begin position="60"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="3">
        <location>
            <begin position="298"/>
            <end position="658"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH82439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="690" mass="74967" checksum="754B3E51D1A35932" modified="2015-07-22" version="1">MTNIPETGKSTRVTVRLVGIQVLVLSLLLTLGGRLWYLQIRNGDEYEAEAAGNHVQQVIEPAVRGSILDSRGEPLADNETRLVVSASRTDLMKMDDDGEAILTKLADVLGMDPKTVMERVRLCDAKTPKPCWNGSPYQPIPITDEATARQALQIRERAEEFPGITAEPSAVRRYGSPNDANTAQVLGYLSPVTDEEIADAEDSDNPLLRTDQIGRSGLERSYDSELRGQAGVTSYRVDKLGRVIGEADKQPGVPGSNLVTSIDSRVQALAEAELEKAMEKARTEFDDNTGTNYKADSGAMVVMEAATGRIVAMASNPSYDPNDWVGGIDSGTYKRLTGKKANYPLLNRAIQGQSAPGSIFKPIPTAAAVNAGYDFDGSYECSSDYSIGGQVFKNFESQSYGAIGLGRALEVSCDTVYYRLAHQEWQNDGGIKPKKKPDDWFYKTAHQFGLGAETGVDLPNEVPGRVPDRQWKKDYWRANKDAWCKQGKKDGDYAQRIAYENCREGMQMRAGDSVNYSIGQGDTLVTPIQMATMYAALANGGTLYKPTVGKAIVSADGKKVDMIEPEEHGKLPMDKETRAAMDNALAGVATRGTAAWRFGGWPQEKIPMHAKTGTAEVYGKQTTSWFATYTDEYAIVMTMSQGGTGSGASAPAVRAVYDALYGVGGKKKALLPEPEKKLPKISPDGRIEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N581</accession>
    <name>A0A0F7N581_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Anthranilate phosphoribosyltransferase</fullName>
            <ecNumber evidence="3">2.4.2.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">trpD</name>
        <name evidence="6" type="ORF">AA958_06815</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>diphosphate + N-(5-phospho-beta-D-ribosyl)anthranilate = 5-phospho-alpha-D-ribose 1-diphosphate + anthranilate</text>
            <dbReference type="Rhea" id="RHEA:11768"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:18277"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="3">Binds 2 magnesium ions per monomer.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the anthranilate phosphoribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.18" evidence="3"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015324.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_06815"/>
    <dbReference type="EnsemblBacteria" id="AKH81972">
        <property type="protein sequence ID" value="AKH81972"/>
        <property type="gene ID" value="AA958_06815"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_06815"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1425"/>
    <dbReference type="OrthoDB" id="1238435at2"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00041"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004048">
        <property type="term" value="F:anthranilate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1030.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00211">
        <property type="entry name" value="TrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005940">
        <property type="entry name" value="Anthranilate_Pribosyl_Tfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000312">
        <property type="entry name" value="Glycosyl_Trfase_fam3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017459">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036320">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035902">
        <property type="entry name" value="Nuc_phospho_transferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43285">
        <property type="entry name" value="PTHR43285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02885">
        <property type="entry name" value="Glycos_trans_3N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00591">
        <property type="entry name" value="Glycos_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47648">
        <property type="entry name" value="SSF47648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52418">
        <property type="entry name" value="SSF52418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01245">
        <property type="entry name" value="trpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="1 3 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Glycos_trans_3N" evidence="5">
        <location>
            <begin position="19"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_3" evidence="4">
        <location>
            <begin position="88"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoribosylpyrophosphate binding" evidence="3">
        <location>
            <begin position="97"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoribosylpyrophosphate binding" evidence="3">
        <location>
            <begin position="104"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoribosylpyrophosphate binding" evidence="3">
        <location>
            <begin position="122"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>anthranilate</name>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>anthranilate</name>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH81972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="355" mass="36443" checksum="8003A2AD42E6C52D" modified="2015-07-22" version="1">MSVQTAAGGDSTAARSWPDVISALIAGQDLSAEDTAWAMDQIMSGTASNAQIAGFAVALRAKGETVAEISGLVRTMYEHAHTIAVPGPTVDVVGTGGDRARTVNISTMSAIVVAGTGARVVKHGNRAASSASGASDVLEKLGVNLDLAPGRVAEVAEEAGITFCFAVKFHPAMRHVAQTRKELGVSTPFNFLGPLTNPARVGAQATGVADARMAPIMAGVLAERGTSALVFRGDDGLDELTTTATSQVWTVRGGAVRQERFDPRDVGIELVPVEALRGADASYNADVARRLLAGETGPVRDAVLLNAAAALTALDADADGPLPDRIAAGIVRAAESIDSGSALRALERWVAASNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5D3</accession>
    <name>A0A0F7N5D3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_10660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015950.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_10660"/>
    <dbReference type="EnsemblBacteria" id="AKH82609">
        <property type="protein sequence ID" value="AKH82609"/>
        <property type="gene ID" value="AA958_10660"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_10660"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2242"/>
    <dbReference type="OrthoDB" id="1552415at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010390">
        <property type="entry name" value="DUF990"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06182">
        <property type="entry name" value="ABC2_membrane_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="281" mass="29692" checksum="E93EBE22BE63D5DE" modified="2015-07-22" version="1">MRGSGALRDAPAVQALRLYGLVAAGGFRRFSTYRAATAAGVFTNTVFGFILAYTFIALWHERPQLGGYDEAQALTFVWIGQALLAPAALLGYGFQEDLQERIRSGDVAVDLYRPADLQLWWLAHDLGRAAFQLLGRGIVPMAVGALAFELALPTAAHTWLLFLLSVTLGCLVSFAIRYLVGLAAFWLLDGQGINLMNSLVAMLLSGTLLPLTVFPGAAGDLAQALPWAAMLQVPADVLLGRHTGAGLAGALAFQAAWAAALLAAGRAMQALATRKVVVQGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5J4</accession>
    <name>A0A0F7N5J4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LuxR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_18325</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017139.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_18325"/>
    <dbReference type="EnsemblBacteria" id="AKH83840">
        <property type="protein sequence ID" value="AKH83840"/>
        <property type="gene ID" value="AA958_18325"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_18325"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3850"/>
    <dbReference type="OrthoDB" id="930905at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="3"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="134"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH83840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="201" mass="20852" checksum="D016E4DFD02F5FA3" modified="2015-07-22" version="1">MIRVLLADDEHLIRGALAALLALEDDLTVVAEAAGGDEALAMARAHRPDVAVLDLQMPGLDGVAVAASLRTAAPGCSAMIVTSHGRPGALKQALSAGVRGFVPKTVSAQRLAEVIRTVHAGGRYVDPELAADAIAAGDSPLTPREAEVLELAADGAPVSDIARRASLTPGTVRNYLSSAMTKLDAENRHAAVRMARERGWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5Y9</accession>
    <name>A0A0F7N5Y9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_19470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH83995">
        <property type="protein sequence ID" value="AKH83995"/>
        <property type="gene ID" value="AA958_19470"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_19470"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="143" mass="15746" checksum="8E87B2BCF76D8AEE" modified="2015-07-22" version="1">MVPTPSVQPEPTTTHPGAGPKREPTTLRDEPAHTRGDHRRGRGGGQQAHRARPHRPHLRSHDRTGHRPAPPRDLRPRTPRRGRTGPPRGPPRCSGSAEPRRHPEQRGHHPLRTVHGHTLRGPPSTAVGPRSGRRILGGRGSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N696</accession>
    <name>A0A0F7N696_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleoside-diphosphate sugar epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_20290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017424.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_20290"/>
    <dbReference type="EnsemblBacteria" id="AKH84135">
        <property type="protein sequence ID" value="AKH84135"/>
        <property type="gene ID" value="AA958_20290"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_20290"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4273"/>
    <dbReference type="OrthoDB" id="1616572at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="6"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="277" mass="29037" checksum="EF0565ED20D57E9C" modified="2015-07-22" version="1">MYLVAGAGGNVGSEVVRALAEQGAEVRALSRGGELSGLPPRTTAVVGDLDDPASLAGPLTGVDGVFLLPGYRDMPGLLAQVVRAGVTRVVLLSGRSAASGDMGNAVTAYMVRSEEAVRAAGIPWTVVRPSALTANALRWLPQLRSGDLVRGPFADVPVACIDPYDVGEVVADTLLGDGHEGKVYELSGPEPLLPGEQVALLGDVLDRPLRFEGLDDATARAEMAAAMPEEYVDAFFDFYRGGALDESPVLSTVYDITGREPRTFEQWAQAHADAFAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N794</accession>
    <name>A0A0F7N794_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nucleoid-associated protein AA958_14690</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_14690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Nucleoid</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the YbaB/EbfC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_14690"/>
    <dbReference type="EnsemblBacteria" id="AKH83268">
        <property type="protein sequence ID" value="AKH83268"/>
        <property type="gene ID" value="AA958_14690"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_14690"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3094"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043590">
        <property type="term" value="C:bacterial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1310.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00274">
        <property type="entry name" value="DNA_YbaB_EbfC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036894">
        <property type="entry name" value="YbaB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004401">
        <property type="entry name" value="YbaB/EbfC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33449">
        <property type="entry name" value="PTHR33449"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02575">
        <property type="entry name" value="YbaB_DNA_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004555">
        <property type="entry name" value="UCP004555"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82607">
        <property type="entry name" value="SSF82607"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00103">
        <property type="entry name" value="DNA_YbaB_EbfC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="102" mass="10577" checksum="32524BAB9A9C9989" modified="2015-07-22" version="1">MQQLLQQAQKMQQELASVQQELAETPVEGTAGGGLVKATVTGSGELTGLVIDPRAVDPEDTETLADLVVAAVRDANNAAQQLQQERLGPLAQGLGGMPGLPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7K0</accession>
    <name>A0A0F7N7K0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_15195</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016653.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_15195"/>
    <dbReference type="EnsemblBacteria" id="AKH83339">
        <property type="protein sequence ID" value="AKH83339"/>
        <property type="gene ID" value="AA958_15195"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_15195"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3201"/>
    <dbReference type="OrthoDB" id="1681222at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50939">
        <property type="entry name" value="SSF50939"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH83339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="426" mass="45303" checksum="652B50B8E2411D1D" modified="2015-07-22" version="1">MGAMASVRQPIDVDIQTITVLPGEDNVIEEEIRVRPLHRAITTVTVGAALVASLFTAAAPAHAAAHPKHWNAPGCDRVVSDGSLSHTRDGGATFAPTTTAERPPYYQLVTGLETLSTPDRLLATDINGRVTRSTDAGCGWHTIAKLGAGHWFVAPGRNGSAYVWELRGDRVYRVDGDELIRMPAFDGEELGGLYGLTANPRRAGHLRAVTDGGRVLESTDHGRSFRPIGTPVPLADVGPHTMFYDAKVSSADFDRIVVGVSDAGGFTSDDAGRTWRRAGLGAAGDKVNGFSLAISPVDPRVVYAKALNVTELEAGDSGRHLYRSTDGGRTFRPVVDQFQDGEDVVIYNGGWMRPDPTDADVVYFEYGDPWSGTNLYRHDADDDELTIRHSGHHGIGALSVSPADPDVLYAGLTSVPGGAPVTGDGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-12-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7K4</accession>
    <name>A0A0F7N7K4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_15385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016675.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH83363">
        <property type="protein sequence ID" value="AKH83363"/>
        <property type="gene ID" value="AA958_15385"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_15385"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3236"/>
    <dbReference type="OrthoDB" id="1775418at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028978">
        <property type="entry name" value="Chorismate_lyase_/UTRA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011663">
        <property type="entry name" value="UTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SSF64288"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="18"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="262" mass="28777" checksum="486FA9CEC85E5951" modified="2015-07-22" version="1">MAPVPSGVLGAVDPTSDRAVFRQIADQLREAIDRGRFKEGSKLPSEAELVEHFGVSRMTVRNSIGVLQSEGLISAEHGKGVFVRPRPPVRRLASDRFARRHRDQGKSAFIVEADAAGSRPEVDSLEVKEEKPSRDISARLGSPRKVLARRRRYLLDGRPVEFAVSYLPLDLARGTRIAEPNPGPGGIYARLEEAGHRLDHFDEEVRARMPSPGEAKLLRLASGVPVIHLVRTAYDTEGRAVEVCDTVMAADAYVLAYQLPAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7N2</accession>
    <name>A0A0F7N7N2_9ACTN</name>
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        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_15765</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_15765"/>
    <dbReference type="EnsemblBacteria" id="AKH83423">
        <property type="protein sequence ID" value="AKH83423"/>
        <property type="gene ID" value="AA958_15765"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="1489522at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032688">
        <property type="entry name" value="ABC2_membrane_2"/>
    </dbReference>
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        <property type="entry name" value="ABC2_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="296"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="340"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="390"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="422"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="484"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="253"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH83423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="510" mass="51813" checksum="9951700B064D720D" modified="2015-07-22" version="1">MAPYRSKLPPVRAGFWQLLRAEFTKLRSVDRWLLTLLAGVVVTVLVSLVSAGGSGTATSDDGGGSGTEAAARVADSFRFVHRPLAGDGSVTARVTDLTLGEGTDAPWAKAGVIVKAGTEPGSPYVALMRTAGHGVRLQYGFEHDVAGGAVAGDAPVWLRLVREGDRLTGYESADGERWREVGSVPAAGLPDTARAGLFVAAPETVRVERSFGSLSIGAGPSAATGVFDNVRLEGGGSGGAGSIEGRTDWRDEAVGPASGPAAGNGPAGGTERAGGTFTVTGSGDIGPLPPAGDLTWMSLAGAQVGLIAFAALGVLFITAEYKRGMIRTTFTAGPRRGRVLAAKGAVLAAVAFAAGLVAAVASFLVGQRALRAGGHRPPQFPEVSLADGPALRAVVGTGLLLALVALFALGLGALLRHTAAAVTIVVVLFVLPLVLGGGLPLGAVEWLFRVTPVAGFGVQSTTPRYEQVGTVCLPEDGCMPQGPWAGLGVLAAWAAVALALAAWRLRRRDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
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    <name>A0A0F7N7P6_9ACTN</name>
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        <submittedName>
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        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="2 3">
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        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_19775"/>
    <dbReference type="EnsemblBacteria" id="AKH84046">
        <property type="protein sequence ID" value="AKH84046"/>
        <property type="gene ID" value="AA958_19775"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_19775"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4167"/>
    <dbReference type="OrthoDB" id="1064289at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="38"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="320" mass="34617" checksum="E5A5D28624F42CB2" modified="2015-07-22" version="1">MLDDVEQWLRTRSWSAADRPDARLLAAKRALGARGTVSVVLPALDEEATVGSIVAAIRAELMAPDGGLVDELVVMDSGSTDRTAEVAAAAGARVVHRDEVLPRMPAVPGKGEVLWRSLLVTRGEIVCFVDADLRDFDTAFVSGIVGPLLTDPGVEFVKAVYDRPLGTGAATGQGGRVTELVARPLLNLHWPLLAGFVQPLGGEYAARRSLLERLPFPVGYGVELGLLVDALHTVGLDALAQVDVGVRRHRHQDDRALGRMAAAIYRTAQVRLARGHLVRPRLTQFDRGAEGAFEPRTYGVDTEERPPMGEIREYVERRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7U4</accession>
    <name>A0A0F7N7U4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cysteine methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_23440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84670.1"/>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_23440"/>
    <dbReference type="EnsemblBacteria" id="AKH84670">
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        <property type="gene ID" value="AA958_23440"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_23440"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4941"/>
    <dbReference type="OrthoDB" id="1928537at2"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA_binding_1" evidence="1">
        <location>
            <begin position="21"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="125" mass="13615" checksum="DADE9A7C9B611779" modified="2015-07-22" version="1">MDDATPSAGPPGPDAGLLDEYADRVLSVAERIPPGRVMTYGDVAEFIDRGGPRQVGRVMALYGSAVPWWRVVRADGRPLPGHEREALEHYRVEGTPLRATTAGDQRIDLRRARWDGSGDGVEGHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7W8</accession>
    <name>A0A0F7N7W8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_12310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_12310"/>
    <dbReference type="EnsemblBacteria" id="AKH82887">
        <property type="protein sequence ID" value="AKH82887"/>
        <property type="gene ID" value="AA958_12310"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_12310"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2588"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH82887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="281" mass="30333" checksum="F720554A0D91E7F0" modified="2015-07-22" version="1">MIVDTLSEPAESGRRNEDHTRVCMSAGNDGIAVVVDGVTPAGPSVCRHGVAWFAARIADEMARAAESQREGSLADCLAQAVTRTAAAHGDGCAPTAPGAPEATMVALRWDANRVDYLVISDATLLFENADGAVEAVLESSLDRVLSRPEVSRLRAEYEAWPVGSVERERAVRAYSDLVDGFRNTPSGFHTVSGDPAVADYTLCGSRPRGELRSAAALTDGMARWRDLFGFGGWEDLLALLRTRGTSELVRQVRSAEDADPQGIRFPRRKARDDASAVYLRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N813</accession>
    <name>A0A0F7N813_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_23800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017982.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_23800"/>
    <dbReference type="EnsemblBacteria" id="AKH84730">
        <property type="protein sequence ID" value="AKH84730"/>
        <property type="gene ID" value="AA958_23800"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_23800"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5016"/>
    <dbReference type="OrthoDB" id="1739932at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="54"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="265" mass="28779" checksum="FC296BD593D04489" modified="2015-07-22" version="1">MAGTTAAATPVGADWQGWQASWDRQQEWYMPDREDRFRVMLDAVEALVGPEPRVLDLACGTGSISARVLRRFPGARTTGVDLDPALLTIARGTFAEDARAEFVTADLAKPDWAARLPHGSYDAVLTSTALHWLFSDQLATLYGQIAGVVREGGIFVNADHMPDPATPAINEAVRNWSKVRQDRERAEGVLDWADWWRVVAADPVLGGPAAERFAIFGDPNDPNEGHADGDVQAPAWHAETLRAAGFAEARTVWAAARDAAVLALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N868</accession>
    <name>A0A0F7N868_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_20835</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_20835"/>
    <dbReference type="EnsemblBacteria" id="AKH84231">
        <property type="protein sequence ID" value="AKH84231"/>
        <property type="gene ID" value="AA958_20835"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_20835"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4392"/>
    <dbReference type="OrthoDB" id="1456605at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH84231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="463" mass="44422" checksum="8CD6CDE27F6A67FA" modified="2015-07-22" version="1">MPPSSPPHQPRHGSAEEEGTAVLCGARLADGRTVDVRLGGGRILAVGPAGSLAGPTGGCGPRVDLGGYVLLPAPVEAHAHLDVALTGAAGAGSGAGAGSGSGSGEGAGAGAGAGVGAPGAGGGAGAAGACVQRRAVEAALLQLGHGATALRTHVRIGGGAGLDDLRAVLAARAALRGLADVAVVAVAPVLTGVAGARGRALLHDAVAMGATAVGGCPDLDPDPAGYAEAVLRVAAEHGCAVDLHCDGADPARLDRVAAVAGELRCGVAVGPCGGLARMPYETAAGVAERLAGAGVAVVCLPQGDCGAVRGVEGGGAARGGPARGARPFAYAPVRLLRAAGVCVAAGTGAVRDEVNPVGGGDPLQSAYLLASAGDADPAAAYATVAGQARAVLGLPEVRVEAGFPAELLAVRGDSVAGALSLGYSRIVIHRGRVVARTSAVREYCDSGAADLDLPRQGLRRTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8G3</accession>
    <name>A0A0F7N8G3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cold-shock protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_13255</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018836124.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_13255"/>
    <dbReference type="EnsemblBacteria" id="AKH83037">
        <property type="protein sequence ID" value="AKH83037"/>
        <property type="gene ID" value="AA958_13255"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_13255"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2789"/>
    <dbReference type="OrthoDB" id="2034748at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019844">
        <property type="entry name" value="CSD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00050">
        <property type="entry name" value="COLDSHOCK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00352">
        <property type="entry name" value="CSD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="2">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH83037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="127" mass="13773" checksum="4377EFF16E012A63" modified="2015-07-22" version="1">MPTGKVKWFNSEKGFGFLSRDDGGDVFVHSSVLPDGVETLRPGQRVEFGVVAGQRGDQALSVTLLDPTPSVAAAQRRKPDELASIVQDLTTLLESVTQQLERGRYPDKAHGRKIAGMLRAVADQLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8L5</accession>
    <name>A0A0F7N8L5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SWIM zinc finger domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_21680</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017638.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_21680"/>
    <dbReference type="EnsemblBacteria" id="AKH84376">
        <property type="protein sequence ID" value="AKH84376"/>
        <property type="gene ID" value="AA958_21680"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_21680"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4567"/>
    <dbReference type="OrthoDB" id="1040546at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04434">
        <property type="entry name" value="SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="3">
        <location>
            <begin position="59"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="119"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH84376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="485" mass="50272" checksum="E24F361C578009A5" modified="2015-07-22" version="1">MGMEGLSERWSVDQVWGLAPDASSRTAGGKLAAAGPWAESGAAGEAVWGLCRGSGSRPYQTVVDLQGPAYKCSCPSRKFPCKHALGLLLRWAQGDVPETPADAPVPEWAAEWLASRREKAERKAAAAPAAERAPDPAAAAEARRRAEQRRQRIAAGAAELEQRLADLLRDGLATAPRGAAWEETAARMVDAQAPGLAARVRELGTLPASGPGWPARLLAECSLLHLLDQGFLRLDELPEPLAATVRSRVGLTVDAAGLLRGGTLRDDWLVLAQEDADDGKLVTRRIWLRGAGTERMALLLAYGAAGRAPQQSLPTGLVLDAELAYYPGAYPLRAALGTVHAGPRTPAAGGGREVRPVPPGSGVAAVAAAYGAALAADPWLEGIPAVLTDVVPVPEEGDEGWQLAERTGDRALPLHPAAERGPGVWQLLAVSGGGPVTVFGEFGHAGFRPLTTWSAGTAVPLTGAVPAAVDAGVTIAAAKGAGAWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8M4</accession>
    <name>A0A0F7N8M4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_24665</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
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    <sequence length="119" mass="13365" checksum="139FDA9B015F7AC6" modified="2015-07-22" version="1">MRIGELAAASGVSTRSLRYYEEQGLIRSRRTPGGWRDFDGSMVERVVMIQHLFAAGLSSTTVHEVLPCLEAPPEERTGVMERLLSQEVERLEAKRRDIDRELDTLRALRAETALVGEAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N925</accession>
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        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <text evidence="2 8">Belongs to the ABC-2 integral membrane protein family.</text>
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    </dbReference>
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    </dbReference>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="251" mass="26631" checksum="92B718C6384EB725" modified="2015-07-22" version="1">MSAYSALAEAGYRAYTRDKTTLFFTFAFPLLFLVVFGLIFHGQDVEESGRPYIAYIAPGVLSWGVGNAAVFGVGFVLMQWRRDDILRVIRMTPTPLSAVLGSRYVLAVGIGLVQAVLFVAVALLPVMGLELAAGWPLAIPVLVLGITAFLALGAIVGSYARTPEAVAAVANFLMVPMAFLSGSFYPLDAMPSWMQAMSWVLPLRHLNDGVSAALTDAGGGADIAVACGGLVAFAAVFGAVAFRVFRWSDRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N946</accession>
    <name>A0A0F7N946_9ACTN</name>
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        <submittedName>
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        </lineage>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Leipoldt F."/>
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                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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        <property type="gene ID" value="AA958_25760"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_25760"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5426"/>
    <dbReference type="OrthoDB" id="1756450at2"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PlsC" evidence="2">
        <location>
            <begin position="41"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH85060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="248" mass="27847" checksum="42086996E5841011" modified="2015-07-22" version="1">MSRRRIGFWYRLVAAICKPPLRLLVKRDWRGAEHIPADGGFITAVNHNSYLDPFFYAHFQYNTGRVPRFLAKDGLFKKGVVGTVMRGTGQIPVYRESTDASKAFRAAVKAVEDGECVAFYPEGTLTRDPGLWPMKGKTGAARVALVTRAPVIPVAHWGANELLPPYGKPRPFPRKTFHLLAGEPVDLSEFYGKEPTPQVLAEVTEVIMDAVTRLLEELRGEQAPAERFDPKTVRAEQRRRSADRKENS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9D6</accession>
    <name>A0A0F7N9D6_9ACTN</name>
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        <submittedName>
            <fullName evidence="4">Cold-shock protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_19790</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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        </subcellularLocation>
    </comment>
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_19790"/>
    <dbReference type="EnsemblBacteria" id="AKH84049">
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        <property type="gene ID" value="AA958_19790"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_19790"/>
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    <dbReference type="OrthoDB" id="2034748at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012156">
        <property type="entry name" value="Cold_shock_CspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019844">
        <property type="entry name" value="CSD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002599">
        <property type="entry name" value="Cold_shock_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00050">
        <property type="entry name" value="COLDSHOCK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00352">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="3">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH84049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="67" mass="7359" checksum="77C90434540F8A68" modified="2015-07-22" version="1">MAQGTVKWFNAEKGYGFIAVDGGADVFVHYSAIQMDGYRTLEEGQRVEFEISQGQKGPQADMVRVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9F2</accession>
    <name>A0A0F7N9F2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_19895</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017359.1">
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_19895"/>
    <dbReference type="EnsemblBacteria" id="AKH84069">
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        <property type="gene ID" value="AA958_19895"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_19895"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4192"/>
    <dbReference type="OrthoDB" id="1254678at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
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    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="112"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="203"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="242"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="363"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="379"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH84069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="395" mass="40658" checksum="C5BE8FFDFF381B25" modified="2015-07-22" version="1">MTKTQPDAATAGDGGPDGAVSRARRILPVLGSLQAYIGLILIVALGVITKGDVFLNQTNLTNAVGAFATRGILAVGVTLVILAAGIDLSVGSLMGFASMSAAIMVAHHDMPVWLIVPACMLIGAGFGLANGIGTAWLKIQSFVMTLAMMSIARGLDRKMSDNESVGTLVAGPDGELTENSESFQKLGTPDNNVLEGILGPDGIYFPVLAFLMVCVVFHLLLSRTTFGRHVYAVGGNPTAARLSGINVTFVIIAVFTLSGMLAGFAGPIDAAYSVSADPQAGYTYELDAIAAAVIGGASLAGGKGTIIGTFVGALILTLLDNVLGLNAVDDNWQLVIKGSIVVLAVVLQRPDLLQSIRNGIDRLRGGRSRTGPDRTPAKAQVPGPAPAPASEETPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9H1</accession>
    <name>A0A0F7N9H1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dynein regulation protein LC7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_20010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_20010"/>
    <dbReference type="EnsemblBacteria" id="AKH84089">
        <property type="protein sequence ID" value="AKH84089"/>
        <property type="gene ID" value="AA958_20010"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_20010"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4215"/>
    <dbReference type="OrthoDB" id="1689828at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004942">
        <property type="entry name" value="Roadblock/LAMTOR2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03259">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Robl_LC7" evidence="1">
        <location>
            <begin position="12"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="145" mass="14862" checksum="66EC45CA69FF0B5B" modified="2015-07-22" version="1">MTQSPAEATGLTWLLEGLLERTPGARHALVLSRDGLKLCHTPELSEDRADQLAAISAGIQSLSHGASVEFGDGSGGVRQSMTEFYGGILFIAEAGSGSHVAVIAAETADPGLVGHNMLELVEQLGEHLSAPPRGPVPAAEGVAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9I5</accession>
    <name>A0A0F7N9I5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_15380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_026276764.1">
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_15380"/>
    <dbReference type="EnsemblBacteria" id="AKH83362">
        <property type="protein sequence ID" value="AKH83362"/>
        <property type="gene ID" value="AA958_15380"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_15380"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3235"/>
    <dbReference type="OrthoDB" id="1687192at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH83362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="116" mass="12005" checksum="6FCB259C922376CB" modified="2015-07-22" version="1">MRTIRVETSAATILLTEAPEPKVRDRQTGEIAKDATSGETLMKVGVVYIDEGESSLIHVTVPESGVSEGLALGAPVALPGLVARPWESVFNGQQRHGIAYRAAAVTLGVVPAGAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9K9</accession>
    <name>A0A0F7N9K9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_26725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018467.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_26725"/>
    <dbReference type="EnsemblBacteria" id="AKH85230">
        <property type="protein sequence ID" value="AKH85230"/>
        <property type="gene ID" value="AA958_26725"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_26725"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5623"/>
    <dbReference type="OrthoDB" id="1444443at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="211" mass="22717" checksum="0E435D9C950171AB" modified="2015-07-22" version="1">MVFGPATGDTGPSGRILEPAEWAAAGIPLLRNPREIVTGLHARHRPTPQTAVIAVLDPDERLRASASLARSEAGRPEVAPDGWDLRNALLARLRRIIPHDLRRRFPVRTAVLLYCRTGDAGWTEEDGAWMWGLRDACTLHGLRCGAYITLTGGGWQVLGEGRGGRRPYADGPPADGEFAEDAPAREVGAAPGPRALQPPEAEAEQTISWAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9M3</accession>
    <name>A0A0F7N9M3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MDMPI_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_20310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017428.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_20310"/>
    <dbReference type="EnsemblBacteria" id="AKH84139">
        <property type="protein sequence ID" value="AKH84139"/>
        <property type="gene ID" value="AA958_20310"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_20310"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4277"/>
    <dbReference type="OrthoDB" id="2055578at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017517">
        <property type="entry name" value="CHP03083_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017520">
        <property type="entry name" value="CHP03086"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024344">
        <property type="entry name" value="MDMPI_metal-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11716">
        <property type="entry name" value="MDMPI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03083">
        <property type="entry name" value="TIGR03083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03086">
        <property type="entry name" value="TIGR03086"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MDMPI_N" evidence="1">
        <location>
            <begin position="20"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="204" mass="21957" checksum="B5A6E804F207F74A" modified="2015-07-22" version="1">MSSENSRTAGENADVHALMEECAAEAARVARGVRPEQLAEPTPCADWDVRALVNHWVCFTSHGLEHRARRTPLPEELPKRDFAAEPGWAEAYAAQLDRAVAAWAAPAAWEGDVDLGFLSMPAPEVAAVIVKEMAVHGWDVARATGQEFRASAGVAALVLRVAEDHGEMYRQYDGFADAVPVPPDAPAFDRALAATGRDPRHPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9X2</accession>
    <name>A0A0F7N9X2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Membrane protein insertase YidC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Foldase YidC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Membrane integrase YidC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Membrane protein YidC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">AA958_16190</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016800.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_16190"/>
    <dbReference type="EnsemblBacteria" id="AKH83492">
        <property type="protein sequence ID" value="AKH83492"/>
        <property type="gene ID" value="AA958_16190"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_16190"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3411"/>
    <dbReference type="OrthoDB" id="524437at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032977">
        <property type="term" value="F:membrane insertase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028055">
        <property type="entry name" value="Membr_insert_YidC/Oxa1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001708">
        <property type="entry name" value="YidC/ALB3/OXA1/COX18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428">
        <property type="entry name" value="PTHR12428"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02096">
        <property type="entry name" value="60KD_IMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03592">
        <property type="entry name" value="yidC_oxa1_cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="214"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="318"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="370"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00033342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AKH83492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="423" mass="46772" checksum="ED54112ABC220FB8" modified="2015-07-22" version="1">MDTVLKPLYIAVSWIIVQFHSLFSLVFDPASGWAWGLSIVALVVVIRIALIPLFVKQIKATRNMQVLQPKMKAIQERYKSDKQRQSEEMMKLYRETGTNPLSSCLPILAQSPFFLALFQVLNKIAGNHEVGVLNATQVAEARQAHVFGAPIAAKFMDSAGKVESLGATLADVRVVTVIMIVLMSGSQFYTQRQLMTKNVDLTVKTPFMQQQKMLMYIFPVMFAVFGINFPVGVLIYWLTTNVWSMGQQMYVIKRNPTPGSKSYAHLLERMQKHVIDRGGVRGRRDRYVVKQMVAKGKDRNEDERKFVSALAKHDLLPQADGTIVKSETPLADAKPGSGDPSRRQQPKRQSKSQRRSHAQSGGSGQRQEDADGAAEPEDKKPASSAAKKKAGGSSGRGGAGGNARNAKSGQRKGPQRPKHPSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9Y9</accession>
    <name>A0A0F7N9Y9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aryldialkylphosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_27395</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="2">Binds 2 divalent metal cations per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily. Phosphotriesterase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018574.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_27395"/>
    <dbReference type="EnsemblBacteria" id="AKH85340">
        <property type="protein sequence ID" value="AKH85340"/>
        <property type="gene ID" value="AA958_27395"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_27395"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5773"/>
    <dbReference type="OrthoDB" id="915852at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009056">
        <property type="term" value="P:catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001559">
        <property type="entry name" value="Phosphotriesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10819">
        <property type="entry name" value="PTHR10819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02126">
        <property type="entry name" value="PTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016839">
        <property type="entry name" value="PhP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51347">
        <property type="entry name" value="PHOSPHOTRIESTERASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="via carbamate group" evidence="2">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="1 3">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR601559-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601559-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH85340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="311" mass="32795" checksum="45B89BE99BECF3AC" modified="2015-07-22" version="1">MSVRTVLGDLPADRLGRTDYHEHLFQVSPLLPGDELDDEARSGQEAAYLRAAGFTAMIEATPVGLGRDPAGVARIARATGLHVVHTTGAHREPHYAPGHPLLALTEAGLAGLFTTELTDGMYADADLTVRTGPAVRAGIVKAGAGYWSLTPFEHRVLAAAGAAHRATGAPVMVHLEYGSAAFEVLAELAGHGVPAHRVVLAHADRNPDPGLHAELCAAGAYLGYDGMARHRSHPDSTVLACLLATAERAGPDRLVVGGDVARRSRYRAYGGMPGLDYLPRRFLPRVAAEGGEELLRAVTVTNPARLLDWAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NA84</accession>
    <name>A0A0F7NA84_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AA958_21545</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017616.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH84354">
        <property type="protein sequence ID" value="AKH84354"/>
        <property type="gene ID" value="AA958_21545"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_21545"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4537"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="468"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="17"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="278"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="368"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="493"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="374"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="513"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AKH84354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="731" mass="74182" checksum="F92F873B302667D3" modified="2015-07-22" version="1">MGREGDGATGRLLAGRYRLGEVLGRGGMGTVWRATDEVLGRAVAVKELRLPTSVDEDEKRRLVTRTLREAKAIARIRNTGAVTVYDVVDEDDRPWIVMELIEGRSLSDLTRDDGPLTPRRAAEVGLAVLDVLRAAHSEGILHRDVKPSNVLISDDGRVVLSDFGIAQVEGDPSITTTGMLVGAPSYISPERARGQKPGPPADLWSLGGLLYAAVEGHPPYDLGSAIATLTAVMTKPIDPPENAGPLEDAIYGLLRKDPGERLDDAGARALLRAVVDAPEDVPGEPSAATAPTTMVPLPVVPDAGGGAGAGQGTAAPARRKTERKKTSRRLTSGAQGSRRTAGRAGTAAGASGAGAAAAGAGSAAAAEAAAPADAPAPPQTPPRSDAAPGTPDRPTAPPRSGAAAAGTSGAAAAGPGTAGAGGREAGAYGAEGPAARTAVTGAAPPAARARAGAGDLAARVAALPRRTLAVIAAVVALAILGTVLAVALGGDDSDSGTSGDGGGQSAGAGTQDGKEAKQDKDQGGSGENDAQEDKRKQDDDGAAGDEDDDSSGPGSGKNEDGGDDGSGSGSGKDPTNVPGGYATLTEPEFKFSVALPDGWKRTATSPGGGGAILSGSSSFPRVQIDFTSQPNNTEGGALSNWQKIEGAVSSSSSGYRKISMKEIEWRGYPTVADWQFSRVQDGQRIRVLDRGFAVDDNHGYAIMISCPENEWNGAECRGLRDTAFETFKPVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAS2</accession>
    <name>A0A0F7NAS2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphate-binding protein PstS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_18070</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Part of the ABC transporter complex PstSACB involved in phosphate import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">The complex is composed of two ATP-binding proteins (PstB), two transmembrane proteins (PstC and PstA) and a solute-binding protein (PstS).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the PstS family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017097.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_18070"/>
    <dbReference type="EnsemblBacteria" id="AKH83797">
        <property type="protein sequence ID" value="AKH83797"/>
        <property type="gene ID" value="AA958_18070"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_18070"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3800"/>
    <dbReference type="OrthoDB" id="1222928at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042301">
        <property type="term" value="F:phosphate ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005673">
        <property type="entry name" value="ABC_phos-bd_PstS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024370">
        <property type="entry name" value="PBP_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12849">
        <property type="entry name" value="PBP_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002756">
        <property type="entry name" value="PstS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00975">
        <property type="entry name" value="3a0107s03"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519370" description="Phosphate-binding protein PstS" evidence="6">
        <location>
            <begin position="28"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="PBP_domain" evidence="7">
        <location>
            <begin position="55"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphate binding" evidence="4">
        <location>
            <begin position="64"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphate binding" evidence="4">
        <location>
            <begin position="200"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="217"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR002756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR002756-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH83797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="377" mass="38580" checksum="A6333D0575211636" modified="2015-07-22" version="1">MKLPPTAPLRAAAAGSLALAGALVLGACGSDDNTGGSGSAGGGAQAAADDVKCAGSGELLASGSSAQKNAMDQWVSDFQGVCPDITVNYKATGSGAGIQEFLQGKTGFAGSDSVLKPEEVQASKKVCRNGEAINIPMLGGPIAIGYNVEGVDDLVLNADVVGRIFSGALTTWNDPAIADLNPDADLPDTKIQPVHRSDESGTTDNFTQYLAAAAENTWPHQPGKKWPVQGGQAADGSSGVSAQVKQTDGAISYFELSFATASDINTVKLDTGAKERVEATSQNASKAIAAAKVTGSGKDLAMQLDFTTDTEGAYPLTLLTYEIACDKGNHKDNLDKVKSFLGYTASEAGQSKLSQLGYAPLPAEVVGKVRTTVESLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NB36</accession>
    <name>A0A0F7NB36_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Branched-chain amino acid ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AA958_18660</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AzlC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017184.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
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            <begin position="12"/>
            <end position="35"/>
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            <end position="155"/>
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    </feature>
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            <begin position="206"/>
            <end position="223"/>
        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010735"/>
        </source>
    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH83887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="233" mass="24576" checksum="47EFC2769D019118" modified="2015-07-22" version="1">MPHQLRADLSRALADSGSVGLGAFPMGVAFGVLVVHSGLDWWWASVFSGLIYAGSLEFLFLGLVLAAAPLGQIALTAFTVNFRHVFYALSFPLHRVRGRAARAYSTFALSDEAYAVTAHPAAQSYPGRRVLWLQVFIHLYWAGGATTGALLGAAVPAGVEGLDFAVTALFTVLALDALRDRPGLAVPALALCCALTARFAVPGGQLFAAFVLFAAALLARYAAVRRREAGARA</sequence>
</entry>
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            <authorList>
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:branched-chain amino acid transmembrane transporter activity"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR043428">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
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            <end position="685"/>
        </location>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
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        </submittedName>
    </protein>
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    </gene>
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        <lineage>
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        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
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    </dbReference>
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            <end position="27"/>
        </location>
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        </location>
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            <end position="139"/>
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            <end position="172"/>
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            <begin position="178"/>
            <end position="216"/>
        </location>
    </feature>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH84913.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBV4</accession>
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                <person name="Winkler A."/>
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                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AKH85671">
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    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_29380"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6200"/>
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    </dbReference>
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    </dbReference>
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            <begin position="1"/>
            <end position="26"/>
        </location>
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            <end position="290"/>
        </location>
    </feature>
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            <begin position="29"/>
            <end position="271"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF12849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH85671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="290" mass="29803" checksum="4C27AC40B18017D6" modified="2015-07-22" version="1">MGSRRRGYGRLASASLVLASLVTACADEAGGTGAMQASGSTTVAPVAADAAEALKAKGLDITVATQGGSAGGIAQLGAGQIDIALSSKPLSDADRSAHAGTDFVTTQIGSDAVGVIVTKKVADAGVTNLTKDQVRGLFEGKITNWSEVGGPDLRVFVYDKEPGRGTREVLDKYIYGDGKPPPPPESGNFAIVGGNLETRNKLKSTPGAVAPLSTGFIEGHNDLAAVTLDGIAPSSENVASGKYPMSRPLYMITNGEPKGTAKEFIDYILTDKGQTLLPKHGYLTLKQIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-10-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NC58</accession>
    <name>A0A0F7NC58_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_30390</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the neocarzinostatin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019039.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH85811">
        <property type="protein sequence ID" value="AKH85811"/>
        <property type="gene ID" value="AA958_30390"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_30390"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6421"/>
    <dbReference type="OrthoDB" id="2087702at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042742">
        <property type="term" value="P:defense response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027273">
        <property type="entry name" value="Neocarzinostatin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002186">
        <property type="entry name" value="Neocarzinostatin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00960">
        <property type="entry name" value="Neocarzinostat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01885">
        <property type="entry name" value="MACROMOMYCIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49319">
        <property type="entry name" value="SSF49319"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0044">Antibiotic</keyword>
    <keyword evidence="2" id="KW-0929">Antimicrobial</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519948" evidence="5">
        <location>
            <begin position="31"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH85811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="137" mass="13595" checksum="C994A3D525014885" modified="2015-07-22" version="1">MPARRIRLATAGVLGAAAASGALAAGPAAAAALAVTVTPSTGLADGQTVSVSGSGYVAGSAIGVSECVRDTVCAEDTVHTTAAADGTLSARYVARRQFQATDRSTGQTITVDCAVEQCQIVAWEQETGPIAQPISFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NC92</accession>
    <name>A0A0F7NC92_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA threonylcarbamoyladenosine biosynthesis protein TsaE</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaE</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_21415</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaD and TsaB. TsaE seems to play an indirect role in the t(6)A biosynthesis pathway, possibly in regulating the core enzymatic function of TsaD.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TsaE family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017595.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_21415"/>
    <dbReference type="EnsemblBacteria" id="AKH84332">
        <property type="protein sequence ID" value="AKH84332"/>
        <property type="gene ID" value="AA958_21415"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_21415"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4508"/>
    <dbReference type="OrthoDB" id="1827295at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003442">
        <property type="entry name" value="T6A_TsaE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02367">
        <property type="entry name" value="TsaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00150">
        <property type="entry name" value="T6A_YjeE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH84332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="176" mass="18294" checksum="255E34AC6775AB5C" modified="2015-07-22" version="1">MSAAMTTTAVQLTVESPEQMQELGRRLAAVLRAGDLVLLTGALGAGKTTLARGLGAGLGVRGAVTSPTFVIARVHPSVSGGPPLVHVDAYRLGGGLEEMEDLDLDVSLPESVVVVEWGEGKVEELAEDRLHVVIERRTGGAPEEEADAAEADVRRVTVTGVGERWAHGALAALART</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCD2</accession>
    <name>A0A0F7NCD2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_26180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018375.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_26180"/>
    <dbReference type="EnsemblBacteria" id="AKH85134">
        <property type="protein sequence ID" value="AKH85134"/>
        <property type="gene ID" value="AA958_26180"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_26180"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5511"/>
    <dbReference type="OrthoDB" id="2006690at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="156"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="209"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH85134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="365" mass="36649" checksum="18D3C69774682A49" modified="2015-07-22" version="1">MDTDRRDDAAGRGALRVETGREAADPAGVPAAAGTEAGGDAAAPADAGADGSAGAGADLGAPAQQDPEGDRGAGVTDGQAAGPADPAAGGGKDLPAAPGADLLPSPDGGPPVPLAPGWQRPRPGPGPGPYGPKPYLPGPYAWVPPAGPRNGSGVAAMILGVVGAVLSFTLLLSPLAVILGGLAIGFGIVTLRRVRRGEARNRGSGLSGIWLGGVAAVVGIGMSILLVVLAVDWFAPVSPETDSAVEAGETVTYDDGLEVTLDARRTGGDLLQVRVRIDNRTGEMVALASSEVNAYPIGSDGGNLEQAFGDALPLTLGEDRSVTAVYHFVLEDGPDDIEFEVSPGGPYEYAYWWTDFDGTGDEQSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-10-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCM1</accession>
    <name>A0A0F7NCM1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_26685</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018461.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH85224">
        <property type="protein sequence ID" value="AKH85224"/>
        <property type="gene ID" value="AA958_26685"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_26685"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5615"/>
    <dbReference type="OrthoDB" id="990666at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH85224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="299" mass="31247" checksum="45AE7ACDBE473FF5" modified="2015-07-22" version="1">MDTAWLEVFRAVARHGSFTAAGAELGFTQSAVSRQIAALEAEFGAPLFDRLPRGVRLTEQGRHALGHAGAALDRLADARRDLAALDRLAAGRLRLGSFATADASLVPRALAAFAADHPGVCVTHVEGYSRDHVAALAAGGLDLALVSGYPEQVAAYDGVELAHLLDDPVLVALPAGHRLAGSTRPLRLADLAGESWVAGSQTPEETLISACLRQGFRPRIDYVAREWTAKFGFVAAGLGLTLVPALAAGALPAGVTLAPLHPEDAPTRTVHTATPHTAHPPSVRGFLPYLHRAASATED</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCT1</accession>
    <name>A0A0F7NCT1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_26460</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018838062.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_26460"/>
    <dbReference type="EnsemblBacteria" id="AKH85183">
        <property type="protein sequence ID" value="AKH85183"/>
        <property type="gene ID" value="AA958_26460"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_26460"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5569"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="6"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="160"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH85183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="220" mass="23820" checksum="891E89B06B94C598" modified="2015-07-22" version="1">MVQKAKILLVDDRPENLLALEAILSALDQHLVRASSGEEALKALLTEDFAVILLDVQMPGMDGFETAAHIKRRERTRDIPIIFLTAINHGPHHTFRGYAAGAVDYISKPFDPWVLRAKVSVFVELYMKNLQLREQAGLLRLQLEGAQKGNGDGAAQTGLLAELSARLAAAEEQAEALSKQLSGANAESAVVATAAHLERKLTGLRKAIDALEPGSRPDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCX8</accession>
    <name>A0A0F7NCX8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_22895</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017834.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_22895"/>
    <dbReference type="EnsemblBacteria" id="AKH84577">
        <property type="protein sequence ID" value="AKH84577"/>
        <property type="gene ID" value="AA958_22895"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_22895"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4822"/>
    <dbReference type="OrthoDB" id="1891666at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="SSF54106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519310" evidence="1">
        <location>
            <begin position="44"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="2">
        <location>
            <begin position="47"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH84577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="254" mass="26026" checksum="84A36CFE9892EE13" modified="2015-07-22" version="1">MSSPHGRHRAARRPGSARTLATRASAAGATLALPVIGASTAFAEEDTTYTVASGDTLSVIAAEQDVDGGWQTLYENNRSVIGEDPNLIAPGMELSLDGPADGTGTNADNASYGTGTAAAEPTAVMPVDGSTPTAGYEASGANWQNGHTGQDWSVPVGTTVKAAAKGTVVEAGWDDSFGYQIVIRHGDGDYTHYAHLSQTDVSAGDTVGMGDRIAQSGATGNVTGPHLHFEVRTTPEYGSAKDPITWLANHGVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7ND28</accession>
    <name>A0A0F7ND28_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Iron-sulfur cluster carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_23310</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the Mrp/NBP35 ATP-binding proteins family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the Mrp/NBP35 ATP-binding proteins family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the MIP18 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017903.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_23310"/>
    <dbReference type="EnsemblBacteria" id="AKH84647">
        <property type="protein sequence ID" value="AKH84647"/>
        <property type="gene ID" value="AA958_23310"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_23310"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4914"/>
    <dbReference type="OrthoDB" id="1413173at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02040">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002744">
        <property type="entry name" value="MIP18-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000808">
        <property type="entry name" value="Mrp_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044304">
        <property type="entry name" value="NUBPL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42961">
        <property type="entry name" value="PTHR42961"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01883">
        <property type="entry name" value="FeS_assembly_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="SSF117916"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01215">
        <property type="entry name" value="MRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FeS_assembly_P" evidence="6">
        <location>
            <begin position="5"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="120"/>
            <end position="127"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH84647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="378" mass="39068" checksum="3A4BEC287F41C3E7" modified="2015-07-22" version="1">MAVTEEAVRAALATVNDPEIHRPITDLGMVKSVEIGTDGSVAVGVFLTIAGCPMRDTITSRVTDAVEKVAGVTSVTVELDVMSDEQRKALAASLRDGKAEREIPFAQPGSLTRVYAVASGKGGVGKSSVTVNLAAAMAADGLKVGVVDADIYGHSVPRMLGTDARPTQVEDMIMPPTAHDVKVISIGMFTPGNAPVVWRGPMLHRALQQFLADVFWGDLDVLLLDLPPGTGDIAISVAQLMPNAEILVVTTPQQAAAEVAERAGAIAVQTHQKIVGVVENMSGLPCPHCGEMVDVFGTGGGKQVAEGLTRTTGAEVPVLGAIPIDVTLRSGGDEGKPVVLTDPESPAGAALRDIAARLGGRPRGLAGMSLGVTPRNKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NE69</accession>
    <name>A0A0F7NE69_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_25460</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018258.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH85007">
        <property type="protein sequence ID" value="AKH85007"/>
        <property type="gene ID" value="AA958_25460"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_25460"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5366"/>
    <dbReference type="OrthoDB" id="1261526at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH85007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="236" mass="24446" checksum="B7B3A7525E82306F" modified="2015-07-22" version="1">MSEITPATTHLITGAGSGIGEALARRLAARGSAGLWFLVRGEARAAELAERFPGAHTVVADLGAPGGLADALAGQELPARLDSLVHVAGVVELGPVAETTPKVWDETLAVNLTGPAELTRLLLPRLRAARGHVVFVNSGAGLNAGPGWGAYGASKHGLKALADALRAEEAGSGVRVTTVYPGRTATPMQAKVHRQEGREYEPGRWIDPESVATTLLTALDLPRDAQLTDVSVRPGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NE76</accession>
    <name>A0A0F7NE76_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_29500</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphate/phosphite/phosphonate binding protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018917.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_29500"/>
    <dbReference type="EnsemblBacteria" id="AKH85688">
        <property type="protein sequence ID" value="AKH85688"/>
        <property type="gene ID" value="AA958_29500"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_29500"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6225"/>
    <dbReference type="OrthoDB" id="988224at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005770">
        <property type="entry name" value="PhnD"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01098">
        <property type="entry name" value="3A0109s03R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519446" evidence="3">
        <location>
            <begin position="28"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH85688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="315" mass="33197" checksum="E89A05E9F98CD152" modified="2015-07-22" version="1">MSTRTRQILSAATVLSALVLTACGSSAADKGGKAEGGARNPDSLVFATIPTEDSTTLEQSFAGVIAMLEKETGKKITFQKATDYAAIIEGQRTGKIDIAVYGPFTYVLALNSGVKIEPAAALVTEKGAKPGYRSYGFVKTGSDIKSLADAKDKKVCFVEPNSTSGYLYPSAGFIEAGVDPEKDIKPVMAGGHDASVLSVVSGQCDLGFAYDVMVEHQLIDKKQIKPGAVETIWKSEIVPGSPAAVSDELDSGLKNKIVTALQTKANADYLKDNGFCTTVCSVGDQGNWGFTKVSDAMYDGVRKVCATTKDEQCQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NEH1</accession>
    <name>A0A0F7NEH1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_26030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018348.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_26030"/>
    <dbReference type="EnsemblBacteria" id="AKH85107">
        <property type="protein sequence ID" value="AKH85107"/>
        <property type="gene ID" value="AA958_26030"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_26030"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5481"/>
    <dbReference type="OrthoDB" id="1567509at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030975">
        <property type="term" value="F:thiamine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015888">
        <property type="term" value="P:thiamine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13545">
        <property type="entry name" value="PBP2_TbpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005948">
        <property type="entry name" value="ThiB-like"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01254">
        <property type="entry name" value="sfuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002520002" evidence="1">
        <location>
            <begin position="25"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="352" mass="38131" checksum="DF9C19EEEFA0BD96" modified="2015-07-22" version="1">MKRIVTTALAASLALGLAACGSDSGDGSGSGAGDKSVTLVTHDSFAVSDGVLKAFEKQSGYTVDILKGKDAGSAVNQAVLSKDNPQGDVFFGIDNTLLSRGLDNGIFTPYEAKGLDRIPGELQLDADEHRVTPVDYGDVCVNYDRAYFEEKNLDPPQTFDDLADPRYKDLLVTENAATSSPGLAFLLATADEYGEEGWEDYWGKLRENGVEVVDGWEQAYYERFSGAGKGDKPLVVSYASSPPVLDMESRPEEATTGVSTGTCFRQIEFAGLLANAGNAEGGKALIDFLIGERFQQDMPLNMFVHPVREDTALPEVFTRYGEEIADPHTLDPATVDDNREQWIKTWTSLVVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NEN4</accession>
    <name>A0A0F7NEN4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH-quinone oxidoreductase subunit K</fullName>
            <ecNumber evidence="5">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">NADH dehydrogenase I subunit K</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">NDH-1 subunit K</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nuoK</name>
        <name evidence="6" type="ORF">AA958_30460</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the complex I subunit 4L family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019051.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_30460"/>
    <dbReference type="EnsemblBacteria" id="AKH85823">
        <property type="protein sequence ID" value="AKH85823"/>
        <property type="gene ID" value="AA958_30460"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_30460"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6437"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050136">
        <property type="term" value="F:NADH dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01456">
        <property type="entry name" value="NDH1_NuoK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001133">
        <property type="entry name" value="NADH_UbQ_OxRdtase_chain4L/K"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039428">
        <property type="entry name" value="NUOK/Mnh_C1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00420">
        <property type="entry name" value="Oxidored_q2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0874">Quinone</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="62"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH85823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="101" mass="10467" checksum="F281CCE8BAF69FB7" modified="2015-07-22" version="1">MTLEPLLLVAAALFSVGLFGALSQQSVVMLMMGLELMLGGVILAAAAVWHFVAPAATDGQVLVVLAVTVMAVEMAVGFAVVTALFRCREVDMTDDAAELKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NF15</accession>
    <name>A0A0F7NF15_9ACTN</name>
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        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_27085</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020441.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_27085"/>
    <dbReference type="EnsemblBacteria" id="AKH87055">
        <property type="protein sequence ID" value="AKH87055"/>
        <property type="gene ID" value="AA958_27085"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_27085"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5705"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="116"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH87055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="336" mass="35489" checksum="4EC5F58DC498C992" modified="2015-07-22" version="1">MAVVVAVDTSAGPEIGYLPLVSLGPAFAGLVGGWRRTVLIGVLALLLCTALAQYNRLLGDPRGYTAMFSVVGVTAAALAAVRMRQAREAELASVRSIAEVAQRVLLRPVPLVAGKLRIALSYTSAVAEARIGGDLYEVVTSPVGVRVIIGDVQGKGLEAVETAAVVLGAFREAAYDEPNLQAVGERVERALDRHLPSEKFVTAIMAEIGDEPTVTLLNYGHPAPLAVKIDGDTHLLEPPARALPLGLGVHGTAPPQPHVHPFSPGDQILFYTDGVTEACNAQGVFYPLTTCAPLLTDTDAESALTAVRQDLIDHVRGPLQDDAAMLLLRYRQDDTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NF67</accession>
    <name>A0A0F7NF67_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_19825</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_19825"/>
    <dbReference type="EnsemblBacteria" id="AKH86916">
        <property type="protein sequence ID" value="AKH86916"/>
        <property type="gene ID" value="AA958_19825"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_19825"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4178"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH86916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="95" mass="10783" checksum="AAC08F8E2A8937C3" modified="2015-07-22" version="1">MTDPRRVRGRRYRPARLATLIRGHWSVEALHHLRDVTFAEDSSRIRTGAAPRVMATLRNLTIGLIRQAGWANIAAAADHYRSRPEHALDLRHLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NF76</accession>
    <name>A0A0F7NF76_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phytase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_20425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_20425"/>
    <dbReference type="EnsemblBacteria" id="AKH86926">
        <property type="protein sequence ID" value="AKH86926"/>
        <property type="gene ID" value="AA958_20425"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_20425"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4304"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027372">
        <property type="entry name" value="Phytase-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13449">
        <property type="entry name" value="Phytase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phytase-like" evidence="1">
        <location>
            <begin position="49"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="345" mass="36901" checksum="7ADF4BDA11230B2F" modified="2015-07-22" version="1">MTAAAVTLAVITGVGVWKGSAGTGTTGPCSEKVGLLGYSDALDTVADSTPVQGLSALAVTGDRSILALGDNRPPRLHSLTLDDARLVPAVGDPTILHPRDDSLAAADIDGEGMAVDGENVLISSEAGPSIRSYRLSDGMQNDEIELPEVLRESSPARRLESLSLSEDRTQLYAGMEGPLHVDGESAGQNHVRILRYTRSPGGEFGEKPQQYAYKTEYGLFLTELIALGGDRLLALERGYMPEGNSVHLYLLSLAKTPDISGRKSISGITDDSWVEKDLLANLVHCPTAGAPRKQAQLNPLLDNIEGMALGEHLPDGRRALYLVSDNNANTKYQTTRFYKMSVDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFF5</accession>
    <name>A0A0F7NFF5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Diaminohydroxyphosphoribosylaminopyrimidine reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_27915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018661.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_27915"/>
    <dbReference type="EnsemblBacteria" id="AKH85427">
        <property type="protein sequence ID" value="AKH85427"/>
        <property type="gene ID" value="AA958_27915"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_27915"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5884"/>
    <dbReference type="OrthoDB" id="900513at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RibD_C" evidence="1">
        <location>
            <begin position="37"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="255" mass="26577" checksum="1F0E6AE9D835E7FF" modified="2015-07-22" version="1">MRRLLPVPADPSALADREWSLDELADAYAYPPGDGVWLRANMVSSVDGAAAFDGRSQPLSSPADMRLFGVLRALADVVVVGAETVRLEGYRPARVREAFAARRAVAGQTPAPPVAVLTASFDLDFSLPLFTAPAVPTLLLTGAQAPAERVAAARAAGVEVVVAGEGRGADPAAAVAALAERGHRRLLTEGGPSALGRFARAGVLDELCLTLAPRVALGDGPRIMHGTASAAEPLGLGLESVMEEAGFLFTRYRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFM5</accession>
    <name>A0A0F7NFM5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_28410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018746.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_28410"/>
    <dbReference type="EnsemblBacteria" id="AKH85512">
        <property type="protein sequence ID" value="AKH85512"/>
        <property type="gene ID" value="AA958_28410"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_28410"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5987"/>
    <dbReference type="OrthoDB" id="1474443at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039446">
        <property type="entry name" value="DauR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039445">
        <property type="entry name" value="DauR-like_HTH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35568">
        <property type="entry name" value="PTHR35568"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13309">
        <property type="entry name" value="HTH_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_22" evidence="1">
        <location>
            <begin position="56"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="129" mass="13814" checksum="81DBC9B3CE9B55D2" modified="2015-07-22" version="1">MTESADHPFVAAVKPLVDAMGGEMVPPEAAAGDDVVLSWEGRPAVAVRLPHLADSLDHMLAELERRHGVPLAQLDRKAKQQVVRVLEARGAFSVRHGVETVAGALGVSRFTIYNYLNREAGQGPPREGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFW0</accession>
    <name>A0A0F7NFW0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_29050</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
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                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <begin position="89"/>
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        </location>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH85622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="404" mass="44607" checksum="21A03584F4F509DD" modified="2015-07-22" version="1">MTEPAGEDGEPNVRLRDLESLLDAITDYAIVRYDAEGRVAGWSRGALLLHGYGEDEVLGRSAAVLYPADDRAAGRPEQALAAAGESGRYESEGWRERKNGERYWASSVLTAIRDVNGDVFGFAEVVKDASEQRRADALFHGLLESAPDAMVIIGPDGRIRLANRQTDLLFGYDRQELIGQEIEVLVPPRFRRQHYAHRSGYLADPRMRPMGLGLELYGLRRDGTEFPVEISLSPLESDEGVLVSAAIRDVTERRETEQRLMRQRDEILELSTPVIQVWDRVLALPLIGTLDTGRAARLTEGLLQRIAETQAEVAILDISGVPTIDTQVAQHLLRTVQAAALMGTESIMSGVRPETAQSMVHLGIDMGRLRSRNTLRDALQLALAILDERDGSAPPARDSLRDAL</sequence>
</entry>
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        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a quinol + 2 Fe(III)-[cytochrome c](out) = a quinone + 2 Fe(II)-[cytochrome c](out) + 2 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:11484"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="7.1.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
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    <dbReference type="EMBL" id="CP011492">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_33580"/>
    <dbReference type="EnsemblBacteria" id="AKH86343">
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        <property type="gene ID" value="AA958_33580"/>
    </dbReference>
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    <dbReference type="PATRIC" id="fig|444103.5.peg.7091"/>
    <dbReference type="OrthoDB" id="262439at2"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008121">
        <property type="term" value="F:ubiquinol-cytochrome-c reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cyt_b/b6_N"/>
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        <property type="entry name" value="Cytb/b6-like_sf"/>
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    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="8">
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        </location>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="AKH86343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="564" mass="62651" checksum="FEC5485918CC90ED" modified="2015-07-22" version="1">MGTRPPTRAKSGERLADWADGRLGIHGAGRKYARKVFPDHWSFLLGEICLYSFIVILLTGVYLTLFFNPSMTEVVYDGSYAPLNGVRMSEAYASTLDISFDVRGGLLVRQIHHWAALIFVVGMLVHMMRHFFTGSFRKPREINWVFGWTMLFIGLFEGLLGYSLPDDLLSGTGLRFVEGATISTPVIGTYLSFFLFGGEFPGHDIIPRFYALHILVLPGLMLALLVAHLILVFYHKHTQWGGPGKTEKNVVGAPFLPVYVAKAGGFFFLVFGLVTIIAAVASINPIWNVGPYRPDQVSTGAQPDWYLGFAEGMVRIMPGWEINAWGHTLSLGVFIPIALFPLMLVVIGAYPFIEAWVTGDKREHHLLQRPRNVPVRTALGTSWLSLYALFLIGGGNDIFATHFHVSVNNVTWALRIAVFVVPVLTFILTKRICLALQRRDRDKVLHGRETGMIKRLPHGEYIEVHEPLSQAELHKLTSHEQPQPYELGPETDANGVRRPPAGITNRVRAKLAHAMFGPHTRVPKPTIEEYRAVAHDHEHAELPAGSGSRELESADESPGGPSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NH60</accession>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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    </gene>
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        <lineage>
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            <authorList>
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
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                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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    </dbReference>
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86789">
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        <property type="gene ID" value="AA958_15270"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_15270"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3216"/>
    <dbReference type="Proteomes" id="UP000034283">
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
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        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="61" mass="7380" checksum="51AE14221D22A5EA" modified="2015-07-22" version="1">MPDRDLRSGDPLAETTDDRGRRRAAFLRDLHEAEALRARVQPRRARAARRRQVHRMRTFRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NHD2</accession>
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    <protein>
        <submittedName>
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        </submittedName>
    </protein>
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    </gene>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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                <person name="Winkler A."/>
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                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AKH86708">
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        <property type="gene ID" value="AA958_12295"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_12295"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2585"/>
    <dbReference type="Proteomes" id="UP000034283">
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH86708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="237" mass="27395" checksum="D2D9D164E58EF8BA" modified="2015-07-22" version="1">MWSGPRSLSTAMLRSWENRRDTTVSDEPFYGYYLRTTGADRPGREHSLATMPTEWRTVVRDLEGPIPNDRAIWFQKHHALHILPDVSREWIPMAANFFLIRNPRHVVASYARIRPIFTAGDLGYDAMVDIFRWIGDRTDQEPLVVDASDVLADPEGQLRALCRALGVDFQMSMLSWPAGRRTTDPEPGDPWYAHVQRTTGFGRPTEAPRALPDQYLEIVKACERSYRFLHERRLRLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NI13</accession>
    <name>A0A0F7NI13_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_19530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_19530"/>
    <dbReference type="EnsemblBacteria" id="AKH86908">
        <property type="protein sequence ID" value="AKH86908"/>
        <property type="gene ID" value="AA958_19530"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_19530"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4116"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="14"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="338" mass="36512" checksum="DFE840CA30F0532C" modified="2015-07-22" version="1">MTYQKIVVERFGAGHVLRPVTASLPQPPPGHARLRVLAAGVGFTDLMARSGDYLLQRTVPFTPGYELTAEVVDFTPGGLQPSWLRAGVRVAAALTKMAAYTEYLTLPLWQLVPLPGGLDPHVAAAIPLDHLTALSLLETHGRLQSGDSVLIHGAGGGVGQAVSRLGALRGLRMYGTASAPGSAELLARHGVTLIDYRREDFETVLRQREPDGIQAVFDHIGGANLRKGYRVLAPGGVLVSYAFSGRPGRMAGDTVRGAVRIQLMNLRPRRRTALSMVPREIRADHDWYHSALTRILGLAQRGEITPRIAGTYPLLRAADAHTALERREITGKVVLTTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NIA7</accession>
    <name>A0A0F7NIA7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hyaluronate lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_01930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_01930"/>
    <dbReference type="EnsemblBacteria" id="AKH86497">
        <property type="protein sequence ID" value="AKH86497"/>
        <property type="gene ID" value="AA958_01930"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_01930"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.417"/>
    <dbReference type="OrthoDB" id="1770293at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011777">
        <property type="entry name" value="Geranylgeranyl_Rdtase_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02032">
        <property type="entry name" value="GG-red-SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="23"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="416" mass="43940" checksum="FEE78C023AF7C4F0" modified="2015-07-22" version="1">MAPGSETGAGAGGAVGGEPEVWDVVVIGAGPAGASAAYAAAGQGRSVLLLERSELPRYKTCGGGIIGLSREALPDGVELPLRDRVNAVTFTMRGRLGRTRRSRRTLFGLVNRAELDARLAEAAQGAGARLRTGVTVARVEQHGPDVPDRRTVAVHLSGGEKVLARAVVGADGSAGRTSSHVGVELEQVDLGLEAEIPVPPEVADDWRGRVLIDWGPLPGSYGWVFPKGDTLTVGVISARGDGAATKRYLEEFTARLGLAGFEPSLSSGHLTRCRAHNSPLSRGRVVVCGDAAGLLEPWTREGISYALRSGRLAGEWAVRIAEAQDAVDARRQALNYAFAVKAGLGVEMAVGRRMLAAFERHPGVFHAALTGFRPAWHMFTKVTQGSTTLGEIVRTHPVAHRALWLLDRKSAVNGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NIE5</accession>
    <name>A0A0F7NIE5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_33680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020660.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH87214">
        <property type="protein sequence ID" value="AKH87214"/>
        <property type="gene ID" value="AA958_33680"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_33680"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.7111"/>
    <dbReference type="OrthoDB" id="1261526at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH87214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="226" mass="22830" checksum="425D3913E6EF5D70" modified="2015-07-22" version="1">MVIGAGPGIGAAVARRFAREGLPVALLARSERTLAHVAEGVAAAGTGIAPGSGVLPLVADVTDEAALRSALDAATGRFGVPDAVVYNAALVRADALGELAPSALLDAWAVNVGGALTAAAHLAPAMARRGGGSFLLTGGMPEPKPAYVSLSLGKAGVHTLARLLDLEYGPGGVHVATVTVDGAVAPGTDFDPDLIAEHYWRLHTQPRSRWEHDVAYTGAKATAPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NIL2</accession>
    <name>A0A0F7NIL2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_00360</name>
        <name evidence="7" type="ORF">AA958_08320</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019671.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_00360"/>
    <dbReference type="EnsemblBacteria" id="AKH86461">
        <property type="protein sequence ID" value="AKH86461"/>
        <property type="gene ID" value="AA958_00360"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86612">
        <property type="protein sequence ID" value="AKH86612"/>
        <property type="gene ID" value="AA958_08320"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_00360"/>
    <dbReference type="KEGG" id="strc:AA958_08320"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1755"/>
    <dbReference type="OrthoDB" id="1510342at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="164"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="52"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH86461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH86612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="257" mass="28548" checksum="0017952638628E8A" modified="2015-07-22" version="1">MLAVIFIAPYLEMIITALRPADELRDRTYLPTSFEWNNLTDVWKESTLGDNLQVTLLIAGGATLLVLLVSLPAAYYTARVRYRGRKAFLLLVLVTQMFQPTALLIGLYREFHQLDMLNSTWTLILANGAFNLAFAIWILTAYISSIPAELEEAAMVDGTGRFGALFRVTLPLAMPGVVTALIFTFISTWNEFVMGLTLMTEPEKQPLTVGINNFIGNYTVEWNYLFAASVVAIIPVVVLFAFIERHVVSGLTAGSVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NIU2</accession>
    <name>A0A0F7NIU2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_12815</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020008.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_12815"/>
    <dbReference type="EnsemblBacteria" id="AKH86727">
        <property type="protein sequence ID" value="AKH86727"/>
        <property type="gene ID" value="AA958_12815"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_12815"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2692"/>
    <dbReference type="OrthoDB" id="1309717at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH86727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="492" mass="52235" checksum="36DD0271FB9AE9B4" modified="2015-07-22" version="1">MTLAPVSFARAADGADAGAAGAEDSRTVTGHLEPGAPDFVYLPVDVPRGVREIHVAYRYDRPQVPAGTTGNALDIGIFDERGTRDGGRGFRGWSGGFRTEFAISADRAATTPAYLPGPVRAGRWHVVLGPYTIAPQGLGYEVTITLRYGPAGETAPPRFPPERAKGRGRAWYRGDCHLHTVHSDGARTPAETAAAARAAKLDFLTTTEHNTSSGHAAWDGLWGDDLLVLCGEEVTTRNGHYLAVGTDPGVFVDWRYRARDDAYPRYVRQIHAAGGLVVPAHPNCPFVGCQWKFGYEGADAVEVWNGPWTTDDELAVAAWDNALTAGREGGGPMDWLPAVGNSDAHRDGQVVGLPQTVVLADDLSRQALLAGLRAGRSWLAESADVDVEFTASGPRGEHAGIGERLRAAPDGRVTVRLKVTGGPAKAQVRFMTDEGQLYATTLADGAGTVEWQTTPSYAAFVRAEVRHPAADGGASGLPGAMAAMTNPIWLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NIU3</accession>
    <name>A0A0F7NIU3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dynein regulation protein LC7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_32265</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020624.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_32265"/>
    <dbReference type="EnsemblBacteria" id="AKH87188">
        <property type="protein sequence ID" value="AKH87188"/>
        <property type="gene ID" value="AA958_32265"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_32265"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6812"/>
    <dbReference type="OrthoDB" id="1785176at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004942">
        <property type="entry name" value="Roadblock/LAMTOR2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03259">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00960">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="Robl_LC7" evidence="2">
        <location>
            <begin position="2"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH87188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="128" mass="13429" checksum="3315715FEF488B82" modified="2015-07-22" version="1">MDWMLRDLAESVPETRHVVVLSSDGLRMAQHGTEPDTADRLAAACAGLQSLAKSIAGVFPNSNGKMRMLVIEVSGGFFYLMAAGAGAYLAVAADEGVDAGLMGQRMRDLVARIGAHLTSPPRSDGQAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A097H0X2</accession>
    <name>A0A097H0X2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Anthranilate synthase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Putative 2-amino-2-desoxy-isochorismate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">cnq728</name>
        <name evidence="5" type="ORF">AA958_30775</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="ChemBioChem" volume="15" first="2385" last="2392">
            <title>A Membrane-Bound Prenyltransferase Catalyzes the O-Prenylation of 1,6-Dihydroxyphenazine in the Marine Bacterium Streptomyces sp. CNQ-509.</title>
            <authorList>
                <person name="Zeyhle P."/>
                <person name="Bauer J.S."/>
                <person name="Steimle M."/>
                <person name="Leipoldt F."/>
                <person name="Rosch M."/>
                <person name="Kalinowski J."/>
                <person name="Gross H."/>
                <person name="Heide L."/>
            </authorList>
            <dbReference type="PubMed" id="25224759"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CNQ-509</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KJ451627">
        <property type="protein sequence ID" value="AIT42118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019099.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_30775"/>
    <dbReference type="EnsemblBacteria" id="AKH85871">
        <property type="protein sequence ID" value="AKH85871"/>
        <property type="gene ID" value="AA958_30775"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_30775"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6505"/>
    <dbReference type="OrthoDB" id="1786019at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071704">
        <property type="term" value="P:organic substance metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd01743">
        <property type="entry name" value="GATase1_Anthranilate_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019999">
        <property type="entry name" value="Anth_synth_I-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006221">
        <property type="entry name" value="TrpG/PapA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236">
        <property type="entry name" value="PTHR11236"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="SSF56322"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chorismate_bind" evidence="3">
        <location>
            <begin position="136"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="GATase" evidence="2">
        <location>
            <begin position="486"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="408"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIT42118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH85871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="671" mass="70780" checksum="A3E5704C2E54AB1F" modified="2015-01-07" version="1">MTTAPGSRRSAAAGAALLDRLLAGPLPPAYALLHRPESGTPGTVDVLLGDVTHPATLAGLPLPDQGAEPPAATAHRTLLVVPYRQLTERGFAAPDDGAPLIAMNVTEQAAVPLDDTLARLPDTPAALTGHRFDLSDEEYADVVRRVVTGEIGTGEGANFVIKRTLLADVGDDPARAALTVFRRLIALEPSAYWTFAIHADGRTFVGATPERHLSVHEGRAVMNPISGTYRYPAGGPTLDGLTAFLRDRKETDELYMVLDEELKMMSRICPAGGRVTGPALKEMARLAHTEYFIEGHTTRDIRDVLRETLFAPTVTGSPLESAARVIARHEPHGRGYYSGIAALVSDEPTGSRNLDSAILIRTADIADDGRLALSVGATLVRHSSPEGEAAETRAKAAALLDALGADGTADTAADPARTPATAAADAAPAAEPGAAGTAPRPPGFADHPAVRDVLRGRNTGIADFWLAATAARPLTVPALEGMKVLVVDAEDTFTAMMVQQLEALGPTAEVRRFDEPYAVDGFDLVVMGPGPGDPRATADPKIAALDTAVAGLLRDRTPFLAVCLSHQVLSLRLGLDLVRRDRPNQGVQRAIDLFGRREHVGYYNTFAAVSPADALDVPGVGRVRVSRDPATGQIDALRGPHFASYQFHAESVLTVEGPRLIGDALLGAIGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MX56</accession>
    <name>A0A0F7MX56_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_00050</name>
        <name evidence="8" type="ORF">AA958_34210</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH80830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014197.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH80830">
        <property type="protein sequence ID" value="AKH80830"/>
        <property type="gene ID" value="AA958_00050"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86441">
        <property type="protein sequence ID" value="AKH86441"/>
        <property type="gene ID" value="AA958_34210"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_00050"/>
    <dbReference type="KEGG" id="strc:AA958_34210"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.11"/>
    <dbReference type="OrthoDB" id="1495174at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="5">
        <location>
            <begin position="25"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="6">
        <location>
            <begin position="112"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH80830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH86441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="175" mass="19721" checksum="082CEF73E96B9358" modified="2015-07-22" version="1">MTEPDRGTDFEAFVLETSAAFSRVARAEASGDLHSAEDAVQVAYMRMFTSWEKIVARPGDRAAYGRTAVRHAVIDQFRRNQRMAPTPLQELPEQESRIGIPDAAYEMIKEGIDELVAKLPDRQRQVITLCILQDVSPEDAGKRLRLKEESVKRNIRMAIKNLKKYVNESGEEGTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MY26</accession>
    <name>A0A0F7MY26_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Electron transfer flavoprotein subunit beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_02015</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">The electron transfer flavoprotein serves as a specific electron acceptor for other dehydrogenases. It transfers the electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014509.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_02015"/>
    <dbReference type="EnsemblBacteria" id="AKH81145">
        <property type="protein sequence ID" value="AKH81145"/>
        <property type="gene ID" value="AA958_02015"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_02015"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.435"/>
    <dbReference type="OrthoDB" id="1027643at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01714">
        <property type="entry name" value="ETF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012255">
        <property type="entry name" value="ETF_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033948">
        <property type="entry name" value="ETF_beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21294">
        <property type="entry name" value="PTHR21294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000090">
        <property type="entry name" value="Beta-ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ETF" evidence="3">
        <location>
            <begin position="24"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH81145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="261" mass="27366" checksum="96A1AA6AD1A43BA1" modified="2015-07-22" version="1">MSLRIVVCVKYVPDATGDRHFSDDLTTDREAVDGLLSELDEYAVEQALQISEAADDAEITVLTVGPEDARDALRKGLSMGADKAVHVEDDELHGTDVMGTSLVLAKAVEHVGYDLVVCGMASTDGTMGVLPAILAERLGVPQVTQLSAVAVADGKVTGRRDGDAASEQLEAALPAVVSVTDQSGEARYPSFKGIMAAKKKPVETLDLDDLGIDAGDVGLAGAWTKVEDATKRPERTAGTVVKDEGEGGKQLAEFLAGQKFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MYW5</accession>
    <name>A0A0F7MYW5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_03755</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_03755"/>
    <dbReference type="EnsemblBacteria" id="AKH81450">
        <property type="protein sequence ID" value="AKH81450"/>
        <property type="gene ID" value="AA958_03755"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_03755"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.790"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023825">
        <property type="entry name" value="CRISPR-assoc_RAMP_BGP1436"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005537">
        <property type="entry name" value="RAMP_III_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03787">
        <property type="entry name" value="RAMPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03986">
        <property type="entry name" value="TIGR03986"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="326"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="335"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH81450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="659" mass="72147" checksum="E1EB6564E6A15F48" modified="2015-07-22" version="1">MEITARSPLLLRNVYDEGGGGVGTFPRRRVPGYEEPQPYIPGSSLAGTIRSLHETIAGGCLRVFNDSFRPGYRNPVKKQDAGWRLALITEVDEKGAPARLRLCRERTVWVDSEILHRGLGGPGELRSGLRVELAGEVEKSGLGRWELRSRGAVVCKAADGDVVVLVTHAGTRKKTRKNPDADGPGKIRGRYFCATGELVGPVRDAVVDDETWRNYLAAVNGTRDVQEARQNPGSAAKGQVSVTHPHDDDVLLGHRDRAAQELREGQVVWVRAELTGEKVLLKEVSLAAVWRHQGTGEARERVPEHLRDAACSDFRALCPSCRLFGSADTGDGSDKDGQSAARQDAYRGHVRFSDAVPRSALSPEVRHLPPMGSPRPGAGQFYLARNETKLENRTAETENDPPLREWGARDENGRRQLRGRKHYWLTGRSEDRPYFHAEREREGTFRKLYGADNKLVSTAESVPQGSVFTSRVFFENLTPAELGGLLSALDPSLLLGTDEGRDASEPVHYGWAVGGGRPLGFGTCTARVTVTSLDSAESRYLGADPPEEADAVALVGAFRRSVSKELGEVWKRLAPVLRLDWAPADRVWYPPAGWLPGPQEHFGDPRVLKASFAFWKESAGAYGKKRGTPYKQLPAPNSPKLGMKVVVDSKALNGNGDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0G3</accession>
    <name>A0A0F7N0G3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_07635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015475.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH82125">
        <property type="protein sequence ID" value="AKH82125"/>
        <property type="gene ID" value="AA958_07635"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_07635"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1605"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002518994" evidence="1">
        <location>
            <begin position="31"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="73" mass="7064" checksum="E2478FD6A9B4EC40" modified="2015-07-22" version="1">MEDAVRRLTLSLAAAAPGLGAVLGASTAAAAQQPPIPAGLCVEGGGKVVHDGTTPPVVYPCEGGSFDGLPVIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0S3</accession>
    <name>A0A0F7N0S3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CoA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_01145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014368.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_01145"/>
    <dbReference type="EnsemblBacteria" id="AKH81003">
        <property type="protein sequence ID" value="AKH81003"/>
        <property type="gene ID" value="AA958_01145"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_01145"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.252"/>
    <dbReference type="OrthoDB" id="1910664at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13380">
        <property type="entry name" value="CoA_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA_binding" evidence="1">
        <location>
            <begin position="12"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="135" mass="14513" checksum="FB4FA38B0E7E38C2" modified="2015-07-22" version="1">MYADQETIRRILTSTGDTWAVVGLSDNPSRAAYGVSRVLQRFGKRIVPVHPKAETVHGEQGYASLADIPFPVDVVDVFVNSDLAGGVADEAVAVGAKAVWFQLDVIDEGAYERVRAAGLDMVMNRCPAIEIPLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0X8</accession>
    <name>A0A0F7N0X8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_01255</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014384.1">
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH81019">
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        <property type="gene ID" value="AA958_01255"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_01255"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.274"/>
    <dbReference type="OrthoDB" id="1779307at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021398">
        <property type="entry name" value="DUF3037"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11236">
        <property type="entry name" value="DUF3037"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH81019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="130" mass="14188" checksum="5D50DF5385B86470" modified="2015-07-22" version="1">MSGREVFEYALLRVVPRVERGEQINAGVLVYCRAHSYLCARTDLDERRLLALDPEVDLAGVRAALRAVEEVGCGGERAGQAAGDDAGRRFRWLVAPRSTVVQPGPVHSGLTEDPEAEVERLLGLLVRVPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N1A8</accession>
    <name>A0A0F7N1A8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nitroreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_05870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015159.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH81806">
        <property type="protein sequence ID" value="AKH81806"/>
        <property type="gene ID" value="AA958_05870"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_05870"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1228"/>
    <dbReference type="OrthoDB" id="1847197at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="1">
        <location>
            <begin position="38"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="224" mass="25047" checksum="3D42DC05DB2E296F" modified="2015-07-22" version="1">MTTSQPYPAPYPTVPYEPLGVPASDAEVRSRAFHEAMTRRRTVRDFSPRPIPDGVLEWAIRTAATAPSGANVQPWRFVVVTDQDRKRRLREAAEQAEREFYARRASPEWLAALAPLGTDWHKPFLESAPAVIVVFEVHKGPQSPRPYYTKESVGIAVGFLLASLHQAGLATLTHTPSPMRFLGEVCERPPEERAAYVIPVGYPADGARVPDIRRKELDDVLIRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N1I9</accession>
    <name>A0A0F7N1I9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glucose/sorbosone dehydrogenase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_06115</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015204.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_06115"/>
    <dbReference type="EnsemblBacteria" id="AKH81851">
        <property type="protein sequence ID" value="AKH81851"/>
        <property type="gene ID" value="AA958_06115"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_06115"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1277"/>
    <dbReference type="OrthoDB" id="567019at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030247">
        <property type="term" value="F:polysaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001919">
        <property type="entry name" value="CBD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008965">
        <property type="entry name" value="CBM2/CBM3_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012291">
        <property type="entry name" value="CBM2_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012938">
        <property type="entry name" value="Glc/Sorbosone_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011041">
        <property type="entry name" value="Quinoprot_gluc/sorb_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00553">
        <property type="entry name" value="CBM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07995">
        <property type="entry name" value="GSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00637">
        <property type="entry name" value="CBD_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49384">
        <property type="entry name" value="SSF49384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50952">
        <property type="entry name" value="SSF50952"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51173">
        <property type="entry name" value="CBM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519687" evidence="1">
        <location>
            <begin position="27"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="CBM2" evidence="2">
        <location>
            <begin position="399"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH81851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="515" mass="54552" checksum="BB315DE6F98F03C2" modified="2015-07-22" version="1">MLRRRSTAPLFLALVLALFAPLTAAAAPEPTVTGSGPAADVPLEELAVTTTQVASGLRRPIDIAAPDDGSGRLFIAEKRGTVRAYHPDTGLAPEPVADLTDVVDESGNERGLLAIVPDPAFPEVRDLYVVYSALPDGAITLARYGLDDGGLEVLLAQEHAEYSNHNGGTLAFGPDGYLYWTIGDGGGAGDPFDSGQRLDTLLGKLLRIDVNRTCGDLPYCVPEDNPFTRTAGARPEIWAYGLRNPWRFSFDPADGSLWLGDVGQGRWEEIDHVARPEQPGANFGWSCREGFQVFDEAQCAGDADYTDPVFTYSPQTGGCAVVGGRVYRGERYAGLLGGTYIGTDYCSSAVWALRPDGRGGYEQAEIGQFPTQITDVGETVDGEFYVVNDLPGGLHKVAFERQRPTCALDVASTTWGGGLSADLTLTNTGSTPIDGWTLKFPLAIGQTVISDWNTDLFQGSDMITAANAAHNAVIEPGESVSLGYLASHTGDVSPPKRATLNGDACTLTASARAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N1Q7</accession>
    <name>A0A0F7N1Q7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LuxR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_10105</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015862.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_10105"/>
    <dbReference type="EnsemblBacteria" id="AKH82520">
        <property type="protein sequence ID" value="AKH82520"/>
        <property type="gene ID" value="AA958_10105"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_10105"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2128"/>
    <dbReference type="OrthoDB" id="930905at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="11"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="146"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH82520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="216" mass="22688" checksum="9455D9A7DB528FB3" modified="2015-07-22" version="1">MTTPVHATPLRVVLADDHIVMRAGLVALLAAEPSIEVVGEAGDGREAVALVARLDPDVALLDLRMPQLDGVGATAAIVAAAARTRVLILTTYDTDSEIERAVEAGATGYLLKDATRAQLVDAIHAASRGETVLAPRVAQRLVAKMRSPAPVTLTPRESEVLAGVAEGLSNAEIGKRLFIGEATVKTHLLRIFAKLDVSDRTRAVVVALESGLLPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N1V7</accession>
    <name>A0A0F7N1V7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">AA958_10475</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="444103.AA958_10475"/>
    <dbReference type="EnsemblBacteria" id="AKH82580">
        <property type="protein sequence ID" value="AKH82580"/>
        <property type="gene ID" value="AA958_10475"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_10475"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2207"/>
    <dbReference type="OrthoDB" id="692375at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 13" id="KW-0418">Kinase</keyword>
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    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519039" description="Histidine kinase" evidence="10">
        <location>
            <begin position="22"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="12">
        <location>
            <begin position="176"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="11">
        <location>
            <begin position="236"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="445"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="261"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AKH82580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="494" mass="50434" checksum="969C9131CFDFDCC5" modified="2015-07-22" version="1">MRWALVKVCLAVTVMVVVAFAVPLGLVVKEMARDRALTNAERIAAGIGPALAITTDAEQLERAVGSTEAGAGGRIAVHVPRGSAEGMPAVRIGEPRAGAADVERASGAGTSLLVAVAGGHALLQPIAVEGDRVAVVEVFVPAGELTEGVALAWLVLAGVGLALIAGSVAVADRLGTRMVRPARRLAGAAHDLGEGKLGVRVEESGPSELRSAAVAFNSMADQVALLLANERELAADLSHRLRTPLTVLRLNAASLGESGAAEQTRQAVAQLEREIDQIIATVREQRGRPAGPQAAAVAGCDVSAVIRERMEFWSALAEDERRSARLAGVDRPAQVPVARAELVAAIDALIGNVFRHTPEGTDFSVDVHHAGDAVIVLASDAGPGIRDPEAALARGQGQGGPGSTGLGLDIVRRVAESTGGDVRIGRSVLGGAEIRLWLALSAGPAAADGERRRQRHRVVRRRRGRAAEGPAAGGAGDGDGTAAAAGAGAGARRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N241</accession>
    <name>A0A0F7N241_9ACTN</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_07335</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82071.1"/>
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    </dbReference>
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    <dbReference type="STRING" id="444103.AA958_07335"/>
    <dbReference type="EnsemblBacteria" id="AKH82071">
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        <property type="gene ID" value="AA958_07335"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_07335"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1536"/>
    <dbReference type="OrthoDB" id="1964047at2"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002518975" evidence="2">
        <location>
            <begin position="33"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH82071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="152" mass="15963" checksum="0E36E318F2E60DFD" modified="2015-07-22" version="1">MPARTTRRSRAALATVAAAAAAVLALAGCSGGDDEDGAAAKPPVSQQEDDRATKDPGPADEERADDTEKVPEEDLEPAEGEFSEKEKTYLKDRVPEGVDPAAILEAGEEACAKIESAAATDDELAREAIRSGDIAHAEDAIRTLCPQYEDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N243</accession>
    <name>A0A0F7N243_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alanine racemase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_03835</name>
    </gene>
    <organism evidence="2 3">
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        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
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            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AKH81463">
        <property type="protein sequence ID" value="AKH81463"/>
        <property type="gene ID" value="AA958_03835"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_03835"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.806"/>
    <dbReference type="OrthoDB" id="1512472at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ala_racemase_N" evidence="1">
        <location>
            <begin position="32"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="406" mass="43128" checksum="3C7D461AB78B1D71" modified="2015-07-22" version="1">MPAHTAPVPDHAALRARYDRATAHLDAPFAAVDTEAFDANAADLVRRAAGKPVRVASKSVRCRALLERVLAAPGFAGIMSFTLAESLWLARSGFADVLLAYPSADRAGFAELTGDPKLAAAVTVMVDDPAQLDLVDAARGRGREEVRVCLELDTSLRLLGGRLRVGARRSPLSDAAALAAVAREVVRRPGFRLVGLMAYEGHVAGVGDDIPGWPLTSRGIRLMQAVARRQLAERRAEAVAAVRRLADLEFVNGGGTGSVQHTAAEDAVTEIAAGSGLYQPRLFDNYTAFTGRPAAVFALPVVRRPGVGVVTVLGGGYPASGPAGPDRPPVPYLPQGLRYDKQEGAGEVQTPLLGPPADDLLVGDRVWFRHAKAGELCERFDALHLIEGERVTETVPTYRGEGRTFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N294</accession>
    <name>A0A0F7N294_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">L-cysteine:1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside ligase</fullName>
            <shortName evidence="8">L-Cys:GlcN-Ins ligase</shortName>
            <ecNumber evidence="8">6.3.1.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Mycothiol ligase</fullName>
            <shortName evidence="8">MSH ligase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">mshC</name>
        <name evidence="11" type="ORF">AA958_04125</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 8">Catalyzes the ATP-dependent condensation of GlcN-Ins and L-cysteine to form L-Cys-GlcN-Ins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside + ATP + L-cysteine = 1D-myo-inositol 2-(L-cysteinylamino)-2-deoxy-alpha-D-glucopyranoside + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:26176"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:58886"/>
            <dbReference type="ChEBI" id="CHEBI:58887"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.1.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 8">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the class-I aminoacyl-tRNA synthetase family. MshC subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.13" evidence="8"/>
    <dbReference type="EMBL" id="CP011492">
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        <property type="term" value="F:cysteine-glucosaminylinositol ligase activity"/>
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        <property type="match status" value="1"/>
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    <keyword evidence="8" id="KW-0862">Zinc</keyword>
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        <location>
            <begin position="38"/>
            <end position="333"/>
        </location>
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        <location>
            <begin position="43"/>
            <end position="46"/>
        </location>
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        <location>
            <begin position="81"/>
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            <begin position="180"/>
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            <begin position="246"/>
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        <location>
            <begin position="286"/>
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        <location>
            <begin position="180"/>
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        </location>
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        <location>
            <position position="43"/>
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        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
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        <location>
            <position position="58"/>
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        </ligand>
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        </source>
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        </source>
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        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
            <dbReference type="Pfam" id="PF01406"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AKH81513.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="409" mass="44252" checksum="9991112B04DC13FD" modified="2015-07-22" version="1">MHAWPAPEVPVLPGTGRDLRLHDTATGGLVTLDPGPEARIYVCGITPYDATHMGHAATYTAFDLVQRVWLDNKREVHYVQNVTDVDDPLLVRAAETGEDWTLLADRETDLFRDDMTALRNLPPREFVGAVEAIPRIVPLVEQLRDAGAAYELDGDIYFSVESDPRFGAVSGLDAATMRELSAERGGDPDRPGKKNPLDPLLWSAAREGEPSWDGGSLGRGRPGWHIECVAISLDHLGMTFDVQGGGSDLIFPHHEMGASHAQVLTGEFPFAKAYVHSGLVALDGEKMSKSKGNLVFVSQVRRDGVDPVAVRLALLAHHYRTDWEWTAHGLEEAERRLARWRDAVSRPEGPPAEGLVEEVRAALAEDLDSPAALAAVDRWAALQRAGGGTDTGAPGVVSRAVDALLGVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2H4</accession>
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        <recommendedName>
            <fullName evidence="2">TerD domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">AA958_08115</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
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            <taxon>Bacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
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        </lineage>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
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            <begin position="1"/>
            <end position="177"/>
        </location>
    </feature>
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            <begin position="181"/>
            <end position="257"/>
        </location>
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            <begin position="226"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH82201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="257" mass="26518" checksum="0CCA4AAC066ADCC5" modified="2015-07-22" version="1">MTHAMAQGSDMSVSVPAVRAVLRWTPGAGVPDVDACVILLDDGGRVRSDADFVFYNQPRHPSGLARKLPKKRQGEGLTDSVEAQLTRQDPSVDRMVLIASADGGTLGRVRNLRVELHDAGSGDAAGGEPFAYVDIQPDGGASSALICGELRRAGGGWQFRAVTKGYATGLVGVAGEFGISVDETDTGHHPTPDSGNDPASEGRPAPGAAQAAQAQQAAQAPQSPQPAAAQPQPAPPIAYGYPPAFTLPPQGPQFIGR</sequence>
</entry>
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    <accession>A0A0F7N2M9</accession>
    <name>A0A0F7N2M9_9ACTN</name>
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            <fullName evidence="2">Pseudouridine synthase</fullName>
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        </recommendedName>
    </protein>
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        <name evidence="5" type="ORF">AA958_04915</name>
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    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
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            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
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    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the pseudouridine synthase RsuA family.</text>
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    </dbReference>
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AKH81644">
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        <property type="gene ID" value="AA958_04915"/>
    </dbReference>
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    <dbReference type="PATRIC" id="fig|444103.5.peg.1034"/>
    <dbReference type="OrthoDB" id="1037615at2"/>
    <dbReference type="Proteomes" id="UP000034283">
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:rRNA pseudouridine synthase activity"/>
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        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
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        <property type="project" value="UniProt"/>
    </dbReference>
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        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000748">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluB/E/F"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018496">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00093">
        <property type="entry name" value="TIGR00093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01149">
        <property type="entry name" value="PSI_RSU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S4" evidence="4">
        <location>
            <begin position="112"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="22"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH81644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="348" mass="38830" checksum="EB2DB82BCACE304E" modified="2015-07-22" version="1">MRSSGGRNSRKPSGSDPRGAGGKRDAQQRRQGRPRSEERGRPRPEERRYEKSGVPQGERPGGPGKGGRGRGGAPARPARSREYDAQLEERARARHTKPQRALPKTFGEPEGERLQKVLARAGMGSRRACEELIDQARVEVNGRIVTEQGLRVDPEKDEIKVDGLTVATQSYLFFALNKPVGVVSSMDDPEGRQNLGDYVDNRETRLFHVGRLDTETEGIILLTNHGELAHRLTHPRYGVKKTYLAAIQGPLPRDLGKRLKNGIRLDDGYAKADDFRVVENTGKNYLVEVVLHEGRKHIVRRMLAESGFPVDKLVRTRFGPIALGDQKSGWLRRLTNTEVGMLMKEVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2Q1</accession>
    <name>A0A0F7N2Q1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_12300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_12300"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2586"/>
    <dbReference type="Proteomes" id="UP000034283">
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    </dbReference>
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        <property type="entry name" value="ACP-like_sf"/>
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        <property type="entry name" value="AMP-bd_C"/>
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        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
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        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="129"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="510"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH82885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="590" mass="64047" checksum="027D7BB28AB30DFD" modified="2015-07-22" version="1">MERAWLAALDMPPTDFLPEDAKFYDQGGTSLRVIMLHTLLEEGLDVSVDIVELFDSLATLRFGDWAKQLMESTSQVTGSKSGVSLPTPSAGRVGAGDELAVALPSGSHVAGVPDRSGLVSIGDRIAVLAREFPDRTALIEVRPDGTEIVLTWSEALDRINAAARALEKRGVGEESTVIVGLPNGIDHVVTTLATWMLGARVIPVNPALPEREYTELIGKVPGAFAVGTRPSEIQVTELDGEDRSYVPARGVPRSAALTGGSTGTSRIVCRRHPWLYDPEQSTPAGYELPGFRFGQVQLVALPMYHGGFLELHNGLAMGHTVVIMVSFAPTLLLRLVERHRVNFFLLVPTQMRAVAAVHDVPRYDLSSVEAMYHQSAKCPEAVKRRWLEILPPERVYEDYGSVENVGYLRIRGDEWLEHPGSVGRPGNGVEVRVVGDDGQDVPPGTVGAIYLKSPGAVQPTYLGGGPDLPENDGFLTVGDLGYLDEEGYLHLVDRRSNVINVGGLNIHPSEIEDVLLELDSVADAAVTGRRHAILGERVHALVVRGSSGLTEEQLMAHCRARLALSKVPHAYEFVDQLPRDSSGKLRRHEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-10-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2Q5</accession>
    <name>A0A0F7N2Q5_9ACTN</name>
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        <submittedName>
            <fullName evidence="3">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_05175</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
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            <taxon>Streptomyces</taxon>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
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        <property type="protein sequence ID" value="AKH81689.1"/>
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        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH81689">
        <property type="protein sequence ID" value="AKH81689"/>
        <property type="gene ID" value="AA958_05175"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_05175"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1087"/>
    <dbReference type="OrthoDB" id="990666at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH81689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="311" mass="32768" checksum="7197890FBA9F01D7" modified="2015-07-22" version="1">MDSRYLRAFVTVAETGGISAAAERLGYAQSSLSAQLRRLEQELGVTVVVRTSTGASLTDAGRRLLPYAREALEIDERMRSAAAAFRPRLRIGAPETLAGEWLPDIVTALDYGAGGPDADAEISVVVGPRERLAEQLAAGELDLAFHFDDGSRTAGPSAVVGHEDVVLVTGPAHPLAGAAEVTEADVLAAEFLVAEPGCSSAVLYDRLSRDLPARTRAATAAGSLPALRRLAAHGRGVALLPRLAVVRDLEDGGLVDLPMATPAGPVAIEARWRRDPGQAEPTLRAVLRLARRHTTQLPPPAALRRTPARTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2W2</accession>
    <name>A0A0F7N2W2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Toxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_12785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016289.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_12785"/>
    <dbReference type="EnsemblBacteria" id="AKH82955">
        <property type="protein sequence ID" value="AKH82955"/>
        <property type="gene ID" value="AA958_12785"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_12785"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2686"/>
    <dbReference type="OrthoDB" id="1996962at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="10"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="69" mass="7075" checksum="1ED40F2E58A23B48" modified="2015-07-22" version="1">MAIELGATGAWTKSTYSAGNGECIEVRSTAPGLVSVRDSKVPDGPVLDFTPESWAAFVAEAAGGAFRTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N318</accession>
    <name>A0A0F7N318_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_13275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016371.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_13275"/>
    <dbReference type="EnsemblBacteria" id="AKH83040">
        <property type="protein sequence ID" value="AKH83040"/>
        <property type="gene ID" value="AA958_13275"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_13275"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2793"/>
    <dbReference type="OrthoDB" id="498436at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="274"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="334"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="422"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="454" mass="46748" checksum="9BDEB7AF75F76862" modified="2015-07-22" version="1">MVEDRTAPVAGPLQQAGRAVGRAVRRPVVGAGRRIRRATDAQGAGESGLGRLMELHMVNAAGDMMITIALASTVFFSVPTDEARGRVALYLAITMAPFAVLAPVVGPLLDRIPHGRRAAMAGTMLARLLLALVLSGAVKTGDLSLYPAALGVLVCSKSYGVVRSAVVPRLLPRRISLVKANSRVTLAGLLATGIAAPVGGLLHFIGPGFPLYGAMVIFGFGVFLAFRMPHAVDSARGEGKARLASGEEGRLRTPQKPGLRSVGPSVLHALQANSALRVLSGLMTLFLAFLLRDNPPGGLRPELALGMAAVAAGTGNALGSVIGSWLRSRGPEKLIALLLTLALTTTVLAAVFYSLPLLICVAAMAGFAQSLAKLSLDALIQRDVPEYVRTSAFARSETVIQLSWVAGGAIGILLPLNGVGGMAAGAAVVAVGLAATVRGLLTAARHGTPHPRVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N334</accession>
    <name>A0A0F7N334_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_05825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015152.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH81799">
        <property type="protein sequence ID" value="AKH81799"/>
        <property type="gene ID" value="AA958_05825"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_05825"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1219"/>
    <dbReference type="OrthoDB" id="2222902at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="276" mass="29953" checksum="FB4E983E92AA50E4" modified="2015-07-22" version="1">MTYANGTRGASGGWEARYRAALERGAGRGEALLTGVAALALYGFRSVPAAADVRVVDVLVPPRRRFTAPPGIRVHHALRRLPPPVRLPPGLPAAPPVRAAADALRDVLDHDRTAALIRELLDTRATPPATAATALRAAGLHTRPDVAAVLATLGPAARPPAETRARTLLRTAELPPPLWHIPLHLDGYWLTTPHAHWPRTGVLLHLTEPPYRHDDGTVEHHNALESLGLHLVHTTPRQLFREPDAFTAAVRDALAAGPHGPARDRLRARPWRRRVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N394</accession>
    <name>A0A0F7N394_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycoside hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_13775</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016454.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_13775"/>
    <dbReference type="EnsemblBacteria" id="AKH83125">
        <property type="protein sequence ID" value="AKH83125"/>
        <property type="gene ID" value="AA958_13775"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_13775"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2901"/>
    <dbReference type="OrthoDB" id="682655at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519074" evidence="4">
        <location>
            <begin position="40"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="NlpC/P60" evidence="5">
        <location>
            <begin position="236"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="168"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH83125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="352" mass="38714" checksum="CA45D46B1081B4C7" modified="2015-07-22" version="1">MRGIGEAQAAGARRRRSIVLPLTGLLALFVPLTGPVAEAEPKPTVEEVHARVQRLYREAEAATDAYNDAEEKAKKQRKEVERLDEAVADASERLAGLKDEAGALARAQYRGGGVPMEAQLLLSDDPEEFVDDLRLARKGQHAQRRLITEVTGTQQRLDGYAKKAAGTYERLERSREAKAGAKERIEERLAEAKELEKKLKAEERERLRRLERQRAREAQARWLDSGILDEIDAEATPAGRKAVAYATDQLGKDYVWGAEGPDTFDCSGLTMRAWEAAGVRIPRTSQTQLAGLARIDVSEMRPGDLIIYHSDASHVGIYVGDRAIVHAPRPGRQVTVAGAGSMPIKAVVRPDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3D3</accession>
    <name>A0A0F7N3D3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">5,10-methylene tetrahydromethanopterin reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_06320</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015237.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_06320"/>
    <dbReference type="EnsemblBacteria" id="AKH81884">
        <property type="protein sequence ID" value="AKH81884"/>
        <property type="gene ID" value="AA958_06320"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_06320"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1320"/>
    <dbReference type="OrthoDB" id="1434838at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023934">
        <property type="entry name" value="LLM_FMN-dep_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04036">
        <property type="entry name" value="LLM_CE1758_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH81884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="367" mass="40879" checksum="A59B1A7526E0FD38" modified="2015-07-22" version="1">MQFGIFSVGDVTQDPTTGRVPSEHERIKAMTAVALKAEEVGLDVFATGEHHNPPFVPSSPTTMLGWIAARTERLILSTSTTLITTNDPVKIAEDFAMLQHLADGRVDVMMGRGNTGPVYPWFGQDIRQGIPLAVENYALLHRLWREDVVDWEGRFRTPLQGFTSTPRPLDGVPPFVWHGSIRSPEIAEQAAYYGDGFFANNIFWPKEHFQRLIELYRTRYAHYGHGTPEQAIVGLGGQVFMRRNSQDAVREFRPFFDNAPVYGHGPSLEEFTEQTPLTVGSPQEVIDKTLTFRESFGDYQRQLFLLDHAGLPLKTVLEQLDLLGEEVVPVLRAEFAKNRPASVPEAPTHAARVAAAAAGQGDEEEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3E3</accession>
    <name>A0A0F7N3E3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_10350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_10350"/>
    <dbReference type="EnsemblBacteria" id="AKH82561">
        <property type="protein sequence ID" value="AKH82561"/>
        <property type="gene ID" value="AA958_10350"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_10350"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2181"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH82561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="227" mass="24745" checksum="44397B549D71CED2" modified="2015-07-22" version="1">MGQGWEGRSRRDRVVTEYAGAALRRRFRPAFLRLTYPTPVDEQQPVTLVLGPRGRGKSTLLRHLRTAWDDVPASLQDIAVHRQRGATCAQGLRIRYPAYAHPEAGDPAALADSADRYCADFRPGARRGACAAGDGPLQSGQAIMGHDAMLALVKAVEFATGPDGGDPVDAGAVRQMPLQLGTTKEVRGLSGPLGFDAYGNPKGRPMAYVELRWRSGFRYVHKARLWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-10-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3R9</accession>
    <name>A0A0F7N3R9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_11020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016009.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH82671">
        <property type="protein sequence ID" value="AKH82671"/>
        <property type="gene ID" value="AA958_11020"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_11020"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2321"/>
    <dbReference type="OrthoDB" id="1439189at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="8"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH82671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="322" mass="34573" checksum="6F761F9D70AB0DA5" modified="2015-07-22" version="1">MPTAPGDVEPRLLRAFAAVAETLHFTRAAGRLYVAQQALSRDIRRLERELGAELFSRTTRQVRLTAEGERLLPYARRVLAAYDALAAAADPRTRPLLVDVGARYSTGQRVLDAARAAAPELELVARFHSGLTGAAAEIAAGRLDVSFGRVAGLAPPTRAGLRHELVRLEPMAVLLPSAHPLAAGPEVPLAALAGETLYAADGNAATAEWTDLARELFAAHDIRLAAPFPEIDGEAEFVRLVHRHGWSVLATTEFAPIPAMTLRPLTTPVPLSPVSLAWRSGLTHPGLTALRTAARTLAREHDWLHLPPDAWLATADQALHAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3V8</accession>
    <name>A0A0F7N3V8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Methionine aminopeptidase</fullName>
            <shortName evidence="2">MAP</shortName>
            <shortName evidence="2">MetAP</shortName>
            <ecNumber evidence="2 3">3.4.11.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Peptidase M</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">map</name>
        <name evidence="6" type="ORF">AA958_07275</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 2">Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 3">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="2 3">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="2 3"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015409.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_07275"/>
    <dbReference type="EnsemblBacteria" id="AKH82059">
        <property type="protein sequence ID" value="AKH82059"/>
        <property type="gene ID" value="AA958_07275"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_07275"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1524"/>
    <dbReference type="OrthoDB" id="1285136at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070084">
        <property type="term" value="P:protein initiator methionine removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01086">
        <property type="entry name" value="MetAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01974">
        <property type="entry name" value="MetAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002467">
        <property type="entry name" value="Pept_M24A_MAP1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00500">
        <property type="entry name" value="met_pdase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00680">
        <property type="entry name" value="MAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 6" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M24" evidence="5">
        <location>
            <begin position="49"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH82059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="286" mass="31081" checksum="9D7A7792D788D715" modified="2015-07-22" version="1">MSGQSSLLAPGTLSPPRAVPAAIPRPEYVGKKGPAPYTGPEVQDAETVERMRTAGRIAARAMAAAAEHIAPGVTTDELDRVAHEYLCDHGAYPSTLGYRGFPKSLCTSVNEVICHGIPDSTVLRDGDIVNLDVTAFIGGVHGDNNATYLVGEVDETSRLLVERTRESLNRAIKAVRPGRQVNVIGRVIESYAKRFGYGVVRDFTGHGVNTAFHSGLIIPHFDDPRATTVMRPGMTFTIEPMLTLGTHEYDMWDDGWTVVTKDRRRTAQFEHTLVVTESGAEVLTLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3X9</accession>
    <name>A0A0F7N3X9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_07295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015413.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_07295"/>
    <dbReference type="EnsemblBacteria" id="AKH82063">
        <property type="protein sequence ID" value="AKH82063"/>
        <property type="gene ID" value="AA958_07295"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_07295"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1528"/>
    <dbReference type="OrthoDB" id="447734at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="467" mass="49662" checksum="E58AA8DF50AF68D8" modified="2015-07-22" version="1">MLRRLDSPGRPAPDPARGTPAAPYAPSRRALLRGGAGLAAGAAATAALTGCGTTIAQGFTGGEPPADRLNFWNPFTGGDGERMVAMQDLYEKDHPDSTLRATTFVWGNPYYTKLSLATIGERPPHVAIAHLSKLPVLAQAGLLSELPADALAKQGMTPEKFDAKPWRKSHVDDRLYGIPIDTHPFALYFRTDVAEKAGLLDGGELVDIDGADKFADALRAAKEVTGVWGGSVASIKDTATQFRMFLSFYTQLGGRPLVGDAGATVTVDLDAAEEALAYIQRLGKEKLIPTGANGQAAITLLTTGEAGFLMDGVWQIVAVLDSGAKFDMRPLPRIFDDAPYACFADSHALVLPRQPKQDDGRLDLSLEFTASLLAKSKLWAEGGHVPAWLPTQRSAAYRELTPQSHYTEAAEGAVYDPVAWYGGAGSNLQNRVGDAVSAALAGRSTPRAAAARVREELRTLADVESPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N451</accession>
    <name>A0A0F7N451_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_04775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014977.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_04775"/>
    <dbReference type="EnsemblBacteria" id="AKH81622">
        <property type="protein sequence ID" value="AKH81622"/>
        <property type="gene ID" value="AA958_04775"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_04775"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1006"/>
    <dbReference type="OrthoDB" id="948454at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="8"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="216" mass="22189" checksum="24F5081C736B5995" modified="2015-07-22" version="1">MGRIVVYGAGGRAGRRAVAEARRRGHEVVAVVRDPAKHAGVAGEGIRLVAGDAADAEAVAATAAGCTAAIAAAAVYGEGTDPDAFFRASAKALVAGLGRAEVPRLVLVGLASLLPDATGRRMLDDPAFPAEFRPFCEAHAAGLDLLRTAPPGLDWLYVSPAGDFDHDAGRTEGGYRVHPHGDAGARISYPDFAVALLDEAESPRHSRTHLAVTGAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4G4</accession>
    <name>A0A0F7N4G4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF1996 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_08580</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015626.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_08580"/>
    <dbReference type="EnsemblBacteria" id="AKH82278">
        <property type="protein sequence ID" value="AKH82278"/>
        <property type="gene ID" value="AA958_08580"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_08580"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1810"/>
    <dbReference type="OrthoDB" id="811477at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018535">
        <property type="entry name" value="DUF1996"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09362">
        <property type="entry name" value="DUF1996"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519177" description="DUF1996 domain-containing protein" evidence="2">
        <location>
            <begin position="28"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1996" evidence="3">
        <location>
            <begin position="113"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH82278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="370" mass="39693" checksum="BA29AC75DBEF76E9" modified="2015-07-22" version="1">MRRSRLYAVLLPALALALCVTALGAIAATGEKARARTATADGSTGDPAQAAHAVHAAHAQPRPVASGDDPDGDGYIPAEPPVTGVVPSDKEPPHRYFHEFQANCSVTHTKPDDPIVYPGQPGKSHDHTFMGNDTTDAHSTTASLDAGGTECKAPGDKSGYWMPTVLDGGQPVLPVGEQVIYYKAGVTDYTSVRPFPKGLRFVVGSPLQSAEEFRDHPGFVEGWECGESYFNVDFPATCPGTRDTQLNIRMQAPSCWDGRYLDTPDHKSHMAYPVVKAGTNNNVCPQSHPVALPVIEFKMAFPVNGDMSRIALSSGRGYSFHYDFINVWDDATLGALVDHCVVGALQCNARGYDETHPEAGAALDENYELP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4H8</accession>
    <name>A0A0F7N4H8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Cyclic pyranopterin monophosphate synthase</fullName>
            <ecNumber evidence="3 5">4.6.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Molybdenum cofactor biosynthesis protein C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">moaC</name>
        <name evidence="7" type="ORF">AA958_12340</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>(8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate = cyclic pyranopterin phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:49580"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:59648"/>
            <dbReference type="ChEBI" id="CHEBI:131766"/>
            <dbReference type="EC" id="4.6.1.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homohexamer; trimer of dimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the MoaC family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.17" evidence="3 5"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016226.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_12340"/>
    <dbReference type="EnsemblBacteria" id="AKH82891">
        <property type="protein sequence ID" value="AKH82891"/>
        <property type="gene ID" value="AA958_12340"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_12340"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2593"/>
    <dbReference type="OrthoDB" id="1595361at2"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061799">
        <property type="term" value="F:cyclic pyranopterin monophosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01420">
        <property type="entry name" value="MoaC_PE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01224_B">
        <property type="entry name" value="MoaC_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023045">
        <property type="entry name" value="Mo_CF_biosynth-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036522">
        <property type="entry name" value="MoaC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002820">
        <property type="entry name" value="Mopterin_CF_biosynth-C_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01967">
        <property type="entry name" value="MoaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55040">
        <property type="entry name" value="SSF55040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00581">
        <property type="entry name" value="moaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 5" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MoaC" evidence="6">
        <location>
            <begin position="18"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="82"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="118"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH82891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="163" mass="16842" checksum="038BDA5E880F7B39" modified="2015-07-22" version="1">MSQPSRLTHLDDTGAARMVDVSAKDVTARTARASGRVLVSPRVVDLLRGTAPGETLPKGDALATARLAGIMGAKRTPELIPLCHPLALSGVTVDLAVADDAVEIAATVRTTDRTGVEMEALTAVSVAALTVVDMVKAVDKAAVITDVRVETKTGGKSGDWSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4P5</accession>
    <name>A0A0F7N4P5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_12850</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016300.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_12850"/>
    <dbReference type="EnsemblBacteria" id="AKH82966">
        <property type="protein sequence ID" value="AKH82966"/>
        <property type="gene ID" value="AA958_12850"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_12850"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2703"/>
    <dbReference type="OrthoDB" id="1864858at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041581">
        <property type="entry name" value="Glyoxalase_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18029">
        <property type="entry name" value="Glyoxalase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="2">
        <location>
            <begin position="8"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="2">
        <location>
            <begin position="141"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH82966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="289" mass="29958" checksum="03EDCACC0A63D6E4" modified="2015-07-22" version="1">MAAFAEGSPCWADATLPDLRAGERFYGELFGWTFTEGGEGTDVGPGFPRHSRAYLDGRPIAALVAKRDGRMPTEWGIHLATPDLAATVEKVRGAGGTVLTGPVAASDAGRSATVADPDGAVFSVWQAGERPGFGVTDVPGSFCWTEVYVRNADAADAFYPAVFGYELQAPPFDAGDFKAWTLPESGRQVAGRAIVGDVLPPEMPPHFLVYFRVGDVGDALRTVRRGGGRVLVDRQEIPGATFAVVVDNQGAAFAVMDGASAVDGEPAGAGSARGEAEPPSAPATSADGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4Q3</accession>
    <name>A0A0F7N4Q3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AA958_09195</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ABC-3 integral membrane protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015719.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_09195"/>
    <dbReference type="EnsemblBacteria" id="AKH82373">
        <property type="protein sequence ID" value="AKH82373"/>
        <property type="gene ID" value="AA958_09195"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_09195"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1940"/>
    <dbReference type="OrthoDB" id="1421296at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001626">
        <property type="entry name" value="ABC_TroCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30477">
        <property type="entry name" value="PTHR30477"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00950">
        <property type="entry name" value="ABC-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="216"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="282"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH82373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="304" mass="30807" checksum="87892906E07A203B" modified="2015-07-22" version="1">MMLEFLEPPFMQRALLAALLVGIAAPAVGIYLVQRRQAIMGDGIGHVALTGVALGFLLNTSPVWTAVLVAAAGAVAMELIRSYGHTRGDLALAMLFYGGMAGGVLLINLAPNGSTANLTTYLFGSVTTVSDSDVTAILWLSVFVLLVTLGLRRQFFAICQDEEFAKVTGLPVRSLNLLLAVTAAVTVTVAMRVVGLLLVSALMVIPVAAAQQATRAFAATLALAVAMGVVTTLSGTVFSYYVDVPPGATIVLFALGLFLLVTALAVPLARVRSRSGGAAVAGAGGPVAAGPGAGAGARAGGGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5F1</accession>
    <name>A0A0F7N5F1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HATPase_c domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_10835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015979.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_10835"/>
    <dbReference type="EnsemblBacteria" id="AKH82639">
        <property type="protein sequence ID" value="AKH82639"/>
        <property type="gene ID" value="AA958_10835"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_10835"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2279"/>
    <dbReference type="OrthoDB" id="1832160at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HATPase_c" evidence="1">
        <location>
            <begin position="14"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="140" mass="15111" checksum="31A68210AE473C97" modified="2015-07-22" version="1">MHAPTAAPTLAALFSPTPRGARRARLLAVHQLAAWGIPRTTATAEAVAVVTAELAANAAVHGRHPGRCFRLRLRLMEHVVRIEISDARPERPLPTAAPPGPVHPESDRGRGLVLVAAFAERWGCFQADAVVKTVWAEVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5F5</accession>
    <name>A0A0F7N5F5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Silent information regulator protein Sir2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_14650</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the polysaccharide lyase 8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016576.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_14650"/>
    <dbReference type="EnsemblBacteria" id="AKH83261">
        <property type="protein sequence ID" value="AKH83261"/>
        <property type="gene ID" value="AA958_14650"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_14650"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3086"/>
    <dbReference type="OrthoDB" id="941406at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008929">
        <property type="entry name" value="Chondroitin_lyas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038970">
        <property type="entry name" value="Lyase_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011071">
        <property type="entry name" value="Lyase_8-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012970">
        <property type="entry name" value="Lyase_8_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004103">
        <property type="entry name" value="Lyase_8_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003159">
        <property type="entry name" value="Lyase_8_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38481">
        <property type="entry name" value="PTHR38481"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02278">
        <property type="entry name" value="Lyase_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02884">
        <property type="entry name" value="Lyase_8_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08124">
        <property type="entry name" value="Lyase_8_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48230">
        <property type="entry name" value="SSF48230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49863">
        <property type="entry name" value="SSF49863"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519223" evidence="2">
        <location>
            <begin position="29"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="domain" description="Lyase_8_N" evidence="5">
        <location>
            <begin position="62"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="Lyase_8" evidence="3">
        <location>
            <begin position="426"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="domain" description="Lyase_8_C" evidence="4">
        <location>
            <begin position="741"/>
            <end position="808"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH83261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="854" mass="91030" checksum="86BF56E2CA616584" modified="2015-07-22" version="1">MEFTRRRLLSTLPAAGLLAVLPARTGFAAGSAAAADPALLLANTRAVFAGTAESNARPEAAAKVAALHATARANLAAMAGTGTATTELFTGVPLGTSDVNLATSYRMLYEIALATRAPGGGLHGDTAAQQRAVDGLVWLHERYYGDQARGYYGNWHNWEIAISTHVGKTFALLADVPGAVPAGLLTTYVASMDAYLRNGKEGDVDLDSRFHTGANLADITTNRILQGALLAAAQEPGGEARIAKALEDQLTVFATIDPYDIRHGNTDGYYADGSFIQHHSVAYTGSYGKGLLTRVVQTLKILDGTGFANTGALVPVVQRWVRDGFAPLIFEGWMMEIVKGRAVVRTTSGYTDVAAVVEAVVDLADYATGAEAAALKSYVKHIRATSRAALDPAGFISPVSVVRYADIVGDDAVPPADLNPAARSVAYNAMDKHVHRRPGFAFALARSSDRISKYEYMSGENLMPWFQGDGAYYLYLSGQDQTRAYGVDYYTVVSPYGLAGATAPVERRGTVPELYDGKLWYDNPGHPLNFTSSSESQNTYVYFPRGTNRHSGGAVLGAYGTSAMVQSDDVAYAQRERLPDDFVVYRNATATKSWFMLDDEIVVLAAGVGDPAGRTVTTTVDARTADPSADVAVTGVRRDGRAWEGPGTAQLSWLRYADAAEGTAVGYVFLAAPRVRVGLEDVTRSRRVVRTGNPDTAVTRTVFSATVDHEPRHGLARLAYALVPHASAAQLDAYRRGGPLTVTANSPRLQAVRHSGLRLTAANAFTPGRHDTAELSIDGPASVLVRTGDDGRVEVAVADPTMDRDTVTVVLRGRPLRKADGDDAVRVSRVAGGTKLVVDTHHAYGRSLTVSLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5P5</accession>
    <name>A0A0F7N5P5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Adenosylhomocysteinase</fullName>
            <ecNumber evidence="4">3.3.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">S-adenosyl-L-homocysteine hydrolase</fullName>
            <shortName evidence="4">AdoHcyase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ahcY</name>
        <name evidence="9" type="ORF">AA958_11335</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 6">
            <text>H2O + S-adenosyl-L-homocysteine = adenosine + L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:21708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="3.3.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4 6">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
        <text evidence="4 6">Binds 1 NAD(+) per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 6">Amino-acid biosynthesis; L-homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 7">Belongs to the adenosylhomocysteinase family.</text>
    </comment>
    <dbReference type="EC" id="3.3.1.1" evidence="4"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016060.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_11335"/>
    <dbReference type="EnsemblBacteria" id="AKH82723">
        <property type="protein sequence ID" value="AKH82723"/>
        <property type="gene ID" value="AA958_11335"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_11335"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2385"/>
    <dbReference type="OrthoDB" id="522981at2"/>
    <dbReference type="UniPathway" id="UPA00314">
        <property type="reaction ID" value="UER00076"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004013">
        <property type="term" value="F:adenosylhomocysteinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00401">
        <property type="entry name" value="SAHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00563">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042172">
        <property type="entry name" value="Adenosylhomocyst_ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000043">
        <property type="entry name" value="Adenosylhomocysteinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015878">
        <property type="entry name" value="Ado_hCys_hydrolase_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020082">
        <property type="entry name" value="S-Ado-L-homoCys_hydrolase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23420">
        <property type="entry name" value="PTHR23420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05221">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00670">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001109">
        <property type="entry name" value="Ad_hcy_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00996">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00997">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00936">
        <property type="entry name" value="ahcY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00738">
        <property type="entry name" value="ADOHCYASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00739">
        <property type="entry name" value="ADOHCYASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 4 6" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4 6" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AdoHcyase_NAD" evidence="8">
        <location>
            <begin position="245"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="211"/>
            <end position="213"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
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        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
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    <feature type="binding site" evidence="4">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="274"/>
            <end position="279"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="332"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="353"/>
            <end position="355"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="401"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007122"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00563"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR001109-1"/>
        </source>
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        <source>
            <dbReference type="RuleBase" id="RU000548"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU004166"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH82723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="487" mass="53019" checksum="E9B19655134E55B9" modified="2015-07-22" version="1">MTSTTTATSPDFKVADLSLAAFGRKEIQLAEHEMPGLMAIRKEYAEARPLAGARVTGSLHMTVQTAVLIETLTALGAEVRWASCNIFSTQDHAAAAVAVGPDGTPDDPRGVPVFAWKGETLEEYWWCTEQALTWPGTDTGGPNMILDDGGDATLLVHKGVEFEKDGKVPSPDTAESDEERVILQLLTRTVAETPQKWTQLASEIRGVTEETTTGVHRLYEMHQAGTLLFPAINVNDSVTKSKFDNKYGCRHSLVDGINRATDVLIGGKTAVICGYGDVGKGCAESLRGQGARVIITEIDPICALQAAMDGYQVARLEDVVETADIFVTATGNKDIILAEHMQRMKHQAIVGNIGHFDNEIDMAGLAKLPGIVKDEVKPQVHTWTFPDGRVLIVLSEGRLLNLGNATGHPSFVMSNSFANQTIAQIELFTKTSEYPTGVYVLPKHLDEKVARLHLDALGVRLTELRPEQASYIGVQVEGPYKPDHYRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5Y3</accession>
    <name>A0A0F7N5Y3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GCN5 family acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_08265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
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            <taxon>Streptomycetaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
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        <location>
            <begin position="1"/>
            <end position="162"/>
        </location>
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    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="162" mass="18068" checksum="73F42FEDDBEE9A5D" modified="2015-07-22" version="1">MLIRDATADDWPAIWPFFHRIVAAGETYPYPLDMSAEQGREVWLLPPPDRTTVAIDDEGLIVGSAKMNANRQGNGDHVASASYMVDPDRHARGVGRALCEDSLRWARARGFLSMEFNAVVETNLYAVKLYESLGFRITGTQPRAFRHPSEGLVGLHCMHVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N606</accession>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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    <dbReference type="PATRIC" id="fig|444103.5.peg.4131"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    <feature type="domain" description="Lant_dehydr_C" evidence="1">
        <location>
            <begin position="23"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="362" mass="40691" checksum="D7B7199A8A5CA191" modified="2015-07-22" version="1">MTDQPAPEAPQAPAAGTTPPGEWQALHVYYAANPVPLLLQCVRPLVRELYDDGLLDGWFFLNYWLEGPHVRLRLRPSSPGREAEVRARAERAVDAFLAERPALYQVDSGFLNEFYNQLFDIEFRPEDRVAYTDADGRMNLRPNNSRAWLPYEPEYGKYGGPAGVALAEWHFARSSELVCDALRGKNLHLRTVLLGTSAQLMLIMSTAFLPEDDRLADFLDRYYTFWHRAFPDTGFIGSAEYERKADEVAPGLLTWHGRIRAAAAGEGTLPGLLDRWAGHCHELRARVVELAGRGELVFRSWDGTQDEPVDDPDEALERLLSPYMHMTNNRLHVTIQDEAYLSHVLARALHARAAAPATGGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N684</accession>
    <name>A0A0F7N684_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Porphobilinogen deaminase</fullName>
            <shortName evidence="6">PBG</shortName>
            <ecNumber evidence="6">2.5.1.61</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Hydroxymethylbilane synthase</fullName>
            <shortName evidence="6">HMBS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Pre-uroporphyrinogen synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">hemC</name>
        <name evidence="10" type="ORF">AA958_20200</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 6">Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + 4 porphobilinogen = hydroxymethylbilane + 4 NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57845"/>
            <dbReference type="ChEBI" id="CHEBI:58126"/>
            <dbReference type="EC" id="2.5.1.61"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>dipyrromethane</name>
            <dbReference type="ChEBI" id="CHEBI:60342"/>
        </cofactor>
        <text evidence="6">Binds 1 dipyrromethane group covalently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="6">The porphobilinogen subunits are added to the dipyrromethane group.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the HMBS family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.61" evidence="6"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_20200"/>
    <dbReference type="EnsemblBacteria" id="AKH84120">
        <property type="protein sequence ID" value="AKH84120"/>
        <property type="gene ID" value="AA958_20200"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_20200"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4254"/>
    <dbReference type="OrthoDB" id="1450400at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004418">
        <property type="term" value="F:hydroxymethylbilane synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018160">
        <property type="term" value="P:peptidyl-pyrromethane cofactor linkage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006779">
        <property type="term" value="P:porphyrin-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00260">
        <property type="entry name" value="Porphobil_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000860">
        <property type="entry name" value="HemC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022419">
        <property type="entry name" value="Porphobilin_deaminase_cofac_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022417">
        <property type="entry name" value="Porphobilin_deaminase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022418">
        <property type="entry name" value="Porphobilinogen_deaminase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036803">
        <property type="entry name" value="Porphobilinogen_deaminase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11557">
        <property type="entry name" value="PTHR11557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01379">
        <property type="entry name" value="Porphobil_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03900">
        <property type="entry name" value="Porphobil_deamC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001438">
        <property type="entry name" value="4pyrrol_synth_OHMeBilane_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00151">
        <property type="entry name" value="PORPHBDMNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54782">
        <property type="entry name" value="SSF54782"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00212">
        <property type="entry name" value="hemC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00533">
        <property type="entry name" value="PORPHOBILINOGEN_DEAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Porphobil_deam" evidence="8">
        <location>
            <begin position="24"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Porphobil_deamC" evidence="9">
        <location>
            <begin position="250"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="modified residue" description="S-(dipyrrolylmethanemethyl)cysteine" evidence="6">
        <location>
            <position position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AKH84120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="348" mass="35887" checksum="6D705D3E44F54D30" modified="2015-07-22" version="1">MTAAKPTQAKGAGAQEAPRFQRPLRLGTRRSKLALAQSEQVAESVRRLTGRPVELVEITTYGDVSRQHLSEIGGQGVFVAALREAVVHGEVDLAVHSLKDLPTTQPEELVIAAVPPREDPRDVLVARDGLGFEDLLAAGARPRIGTGSARRACQLHAWARSLGGAIETVPVRGNVDTRIGYVQKGEFDAVALAAAGLSRLGRLAEVTELIPLDAVLPAPGQGALAVECASSSAHLAAQLAELDDPQTRVAVTAERTLLAALEAGCSAPVGALADLHAEGPSGAALGTASTVTEMRLRGVVGTPDGSALVQMSATGPVPASYDDAVALGRELAEEMLAKGAAGLMGERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6C1</accession>
    <name>A0A0F7N6C1_9ACTN</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">AA958_09090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015704.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH82357">
        <property type="protein sequence ID" value="AKH82357"/>
        <property type="gene ID" value="AA958_09090"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_09090"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1915"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="97"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH82357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="163" mass="16940" checksum="899C059D07C59861" modified="2015-07-22" version="1">MVFLPRRTTPSARGRADGPLLVAARAAVLVPLAAGAVLVALAALLDGTADAMAWAERGLLCAAVAVLVRSVVTAAVRNVGDGELEVTAVFGSVLLMIAAYFTGPVALVAVPGVALVTGVVSAVRTDRAERRRTRERRERDARVRAHHAEKKRRKRESGGAGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6C5</accession>
    <name>A0A0F7N6C5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_09135</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH82362">
        <property type="protein sequence ID" value="AKH82362"/>
        <property type="gene ID" value="AA958_09135"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_09135"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1925"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519828" evidence="2">
        <location>
            <begin position="26"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH82362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="162" mass="17343" checksum="1ABA400E7DA7C828" modified="2015-07-22" version="1">MLRPRAALAAGIVSLALLTACSDKQEEPPAKDEGKANSSAPAGKPSEEAIEKQDEVPDEWPPEVPLPVGYEIKAASEPTQAEFHSAQVVGVPQEAVSATLKEFEANGFKQTLGDAMSERGIFNYESKKWSISLTVAPMDSKGEMTTEDTGVYTMTYLVGPVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6P1</accession>
    <name>A0A0F7N6P1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_17720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017043.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_17720"/>
    <dbReference type="EnsemblBacteria" id="AKH83741">
        <property type="protein sequence ID" value="AKH83741"/>
        <property type="gene ID" value="AA958_17720"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_17720"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3731"/>
    <dbReference type="OrthoDB" id="1515497at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="43"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="243" mass="26981" checksum="157CA20AC86E889C" modified="2015-07-22" version="1">MTVFHDPAFFDRYAHEYDTADLYEPTPTVDFLAGLVPPGARTLELAIGTGRVALPLAARGVAVEGVDGSTAMVEQLRAKPGGADIPVTIGDMADVPVDGPFHTAYLVFNTLFNLPDQDRQVDCFRNVAAVLEPGGLFVVECFVQDLKEFDRNQRVATRSLTEDTVKMEFLVHDPVAQAVTYQRVTFDANGTALRPLRLRYCWPSELDLMARLAGMRLRERYAGWDRRPFGAASRSHVSVYEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6T4</accession>
    <name>A0A0F7N6T4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pyridoxamine 5'-phosphate oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_13450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016400.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_13450"/>
    <dbReference type="EnsemblBacteria" id="AKH83069">
        <property type="protein sequence ID" value="AKH83069"/>
        <property type="gene ID" value="AA958_13450"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_13450"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2828"/>
    <dbReference type="OrthoDB" id="1804797at2"/>
    <dbReference type="Proteomes" id="UP000034283">
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR019920">
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    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03618">
        <property type="entry name" value="Rv1155_F420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="1">
        <location>
            <begin position="7"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="137" mass="14643" checksum="E9DAACC2DF80FC2B" modified="2015-07-22" version="1">MSVALPASLKQVLDGQVFITVATVQPDGAPQASPVWVKRDGDDLLFSTTAERVKARNLSRDPRVSVVVIDPAAPYNYAQVRGTASVTTEGGRELIDELSVKYTGKDYDTFSGGRAGEGTRVVVRVTPEKISGQGNLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6T8</accession>
    <name>A0A0F7N6T8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_10170</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015874.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH82532">
        <property type="protein sequence ID" value="AKH82532"/>
        <property type="gene ID" value="AA958_10170"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_10170"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2141"/>
    <dbReference type="OrthoDB" id="100199at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="216"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="260"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="329"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="375"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="401"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="446"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="470"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="648"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="674"/>
            <end position="690"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH82532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="690" mass="74939" checksum="913DD5AC529007FD" modified="2015-07-22" version="1">MPKLTELSKRILIGRALRSDRLGETLLPKRVALPVFASDPLSSVAYAPGEVLIVLSIAGVGAYSYSPWITAAIVVLMVVVVASYRKTVHAYPSGGGDYEVATTNLGRRAGQVVASALLVDYVLTVAVSVSAGVENLGSAWGFVADNKVLCALIVIGLLTTMNLRGVKESGTLFAIPTYVFVGSVLIMIAWGVFRALVLDDTMRAPTADLEVHSEHAGGLAGFALVFLLLRAFSSGCAALTGVEAISNGVPAFRKPKSRNAATTLAMMGLLAIVMFVGIIILALHTDVRMAERPAEELLRNGEAVGSGFIQNPVIAQVGAAVFGDGSLPFVILAAATALVLFLAANTAYNGFPVLGSILAHDRFLPRQLHTRGDRLAFSNGILFVALLSGALVYAFKADSTRLIQLYIVGVFVSFTFSQTGMVRHWNRALTAEHRPDERRRILRSRAMNGFGAVFCALVLVVVLITKFSHGAWIALAGMLFFYVVMAAIRRHYDRVAQEVAVAEGEEDDAMPRPGHMHSIVLVSQLHRPTMRALAYAKLVRSDKLEALTIGVDAEETRQLQQQWVDSELDVPLTVIESPYREITRPLIAYVKRLRQEKPDTVISVYIPEYVVGHWYEHLLHNQSALRLKARLLFTPGVMVTSVPYQLGSSERAKRRARRSAEWQAPGAVRGPAPAAARKRREPSGRESADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N745</accession>
    <name>A0A0F7N745_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">IclR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_10800</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_10800"/>
    <dbReference type="EnsemblBacteria" id="AKH82632">
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        <property type="gene ID" value="AA958_10800"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_10800"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2271"/>
    <dbReference type="OrthoDB" id="370329at2"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
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        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
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    <dbReference type="Pfam" id="PF09339">
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
            <begin position="6"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH82632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="219" mass="22825" checksum="E72FFF800A4E73BA" modified="2015-07-22" version="1">MPAETSQTLDRGLRVLKLLADTDHGLTVTELSHKLGVNRTVVYRLLATLEQHALVRRDLGGRARVGLGVLRLGRQVHPLVREAALPALRALAEDVGATAHLTLVDGSEALAVAVVEPSWTDYHVAYRAGFRHALDQGAAGRAILKGRGLGPGARETDAELALALTHGELEAGASGAAAPLLGVSGIEGSVGVVMLHEIVPGEVGPRVVSAAREVAQALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N772</accession>
    <name>A0A0F7N772_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">VanZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_22105</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017702.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_22105"/>
    <dbReference type="EnsemblBacteria" id="AKH84440">
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        <property type="gene ID" value="AA958_22105"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_22105"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4656"/>
    <dbReference type="OrthoDB" id="1917609at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006976">
        <property type="entry name" value="VanZ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04892">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="VanZ" evidence="3">
        <location>
            <begin position="23"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH84440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="195" mass="20509" checksum="EFE212479900FD0E" modified="2015-07-22" version="1">MQRHATGGTAALRFRVAGVVLLVLHLTAVWWLTLRPNAVPWVDAANLRPLTTIRAEFGNDPRAALRYTVESLFVLAPAGVLLPLIGGRVDASPVGSFVRTVFAGLMLALVVELLKTTVPGQVANVDTMLLYILGVALAHLAVVPAARARLRRHPAGRAAGAAHAEEAAGAEAAERTADGKAQGTTPRITRVEIAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7M6</accession>
    <name>A0A0F7N7M6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_15500</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1C family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016691.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_15500"/>
    <dbReference type="EnsemblBacteria" id="AKH83379">
        <property type="protein sequence ID" value="AKH83379"/>
        <property type="gene ID" value="AA958_15500"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_15500"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3262"/>
    <dbReference type="OrthoDB" id="741829at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="3">
        <location>
            <begin position="443"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="191"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="455"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="520"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="105"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="455"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH83379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="540" mass="52010" checksum="092271DF5B2B8C43" modified="2015-07-22" version="1">MSTENDGATPRRPDFPPPDAGARSPVESPERASGGAGGAWPTGPERPGGSDAAGPPGGPGAGGHGGARTEQFAAVGAAGGTGSGGHTGPAGGQAGSSGAAGPPGGAGPQWPPPPLSADASPAGPGPAGSPPPTQPGWGSAPPPGGTGWDAAPRPSGNGGRRVGTVVTATLVAALLGGGIGGGIGYWAAEGDDSGSTSTTVSGTQDGQKIENPPGSVAGIAGNALPSVVTIEASGGGGDGASGEEGAATGTGFVYDKQGHILTNNHVVAGAEGSGSLTATFSNGKTYDAEVVGQASGYDVAVIKLTDASDAKLTPLPLGDSDKVDVGDQTIAIGSPFGLSGTVTTGIVSAKNRPVASGDASGQQESYMNALQTDASINPGNSGGPLLDHDGNVIGINSAIRPADSGSPFGGGQGGSIGLGFAIPINQADRVAQNLIETGEPVYAIIGVSVDNSYQGKGAKVSESGSDSTGDPVTPGGPAADAGLQPGDVITKLDDTIVDSGPTLIAQLWAHEPGDKVEITYERGGDQKTTQLTLGEREGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7R1</accession>
    <name>A0A0F7N7R1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_19880</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017356.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_19880"/>
    <dbReference type="EnsemblBacteria" id="AKH84066">
        <property type="protein sequence ID" value="AKH84066"/>
        <property type="gene ID" value="AA958_19880"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_19880"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4189"/>
    <dbReference type="OrthoDB" id="1074175at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="87"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="198"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="256"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="88"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH84066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="291" mass="32417" checksum="F8A2EEC68A04B4C7" modified="2015-07-22" version="1">MSIDTPAGGTTTAARPTPLRGPGRRRARAGLTVLAIVLSVLSVFPVLWLITSAIKPREAVTDGKLLPEDVTWENFRYVLTEVAFDRWLWNSFFTAAIITILALFFHSMAAYALARLRFPGRDGIFVVIFSTLLITPPVILIPLFIVVREMGMLDSYAALIIPPLFNAFGIFLLRQFYLGIPRELEEAAIADGAGYWRIYWSIILPLSRPILAALSVFFFLANWNAFAWPLVATSSENLTVTQVGIASFTTQYGSNWNYILAAAVVAVIPMLMLFLFFQRQMVESIKTSGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N852</accession>
    <name>A0A0F7N852_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_16830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016903.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_16830"/>
    <dbReference type="EnsemblBacteria" id="AKH83599">
        <property type="protein sequence ID" value="AKH83599"/>
        <property type="gene ID" value="AA958_16830"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_16830"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3541"/>
    <dbReference type="OrthoDB" id="1194694at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015815">
        <property type="entry name" value="HIBADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000103">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_binding_2" evidence="1">
        <location>
            <begin position="7"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="298" mass="30212" checksum="CAB4B342961580E6" modified="2015-07-22" version="1">MSAESAVTVLGLGPMGRALAGAFVAAGVRTTVWNRTQGRDTELVGRGALPAASAAEAVAASDLTVVCVVDYDASDAVLRREDVAAALKGRTVANLSADTPTRARDAAAWAADQGIRYLDGAIMTPTSTIGTPHGVFIYSGPKDLYGEHQPVLAALGGAHTHLGEDFGRAAAYDVALLDIFWTTMAGCAHALAVARAEGVGPAELAPFAKGIGAILPEAIEGMAAGVAAEDYSGETNPITSSASSMKHIIATSESHGIDAGVMRAAAGQAQRVIGLGYGTDGFVRLTELVAGRLNRAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8E6</accession>
    <name>A0A0F7N8E6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_17540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017013.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH83709">
        <property type="protein sequence ID" value="AKH83709"/>
        <property type="gene ID" value="AA958_17540"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_17540"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3691"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH83709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="75" mass="8106" checksum="4868FF588F8AABBC" modified="2015-07-22" version="1">MHRGTDRTIAPATRFRLDGPLLQGGTQRLHLLRGEAAGDELIVIEAVDGRQRLGQHRGLEALIALLGAGERCVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8G7</accession>
    <name>A0A0F7N8G7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_13285</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016373.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_13285"/>
    <dbReference type="EnsemblBacteria" id="AKH83042">
        <property type="protein sequence ID" value="AKH83042"/>
        <property type="gene ID" value="AA958_13285"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_13285"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2795"/>
    <dbReference type="OrthoDB" id="1388804at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032830">
        <property type="entry name" value="XPB/Ssl2_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13625">
        <property type="entry name" value="Helicase_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase_C_3" evidence="4">
        <location>
            <begin position="590"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="434"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="487"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="752"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="787"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="491"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="756"/>
            <end position="770"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH83042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="900" mass="93448" checksum="2FD57F6DC2144020" modified="2015-07-22" version="1">MTTGNPARTLAEELRGRPDTALAGLLRARPDLLTPVPGDLTQLATRAGTRASVVRALERLDRFTQQTAQALAVAPDPCPYDVLAGLMGDEHDTVAALPRAVAELRAQALVWGDEQRLRLVRTARELLTPQASGSATGLGPAAAEVATGMSPGRLQQVLANAGLPATHDPVSAAESLTALFSDPRRMADLLDQAPPEAVTVLGRLTWGPPYGTVSAQPPAHVRWLLDRGLLLPTAPGSVLLPREVALHLRDGRAHRSVAAVPPEPVAAGTYGMRVVDATAAGQAAVAVETVEELLGQWATASPPVLRAGGLAVRDLKRTATALDVAEPQAAFWVELAYGAGLLASDGETDERYAPTPAYDEWQALPAAERWAELAAAWLAATRTPGLVGGRDGKGRALSALGEGLDRGAAPEVRRAVLGLLAGLPEGTAATPDSVVARLRWERPPRGGGAAEGEEEDLRTRLARWTLEEAELLGVTGRGALATHGRALLSPPEEEGPPPAAPEADTADAAPPPPPRTRPRVGRPSDNHPAPPLATSTDAPATPATGATPATGLPTEAPRHPAPATPAEARAAALRAARALAPLLPPPVDHVLLQADLTAIAPGPLKRELAAVLGVLAEVESKGGATVYRFTQSSVRRALDAGRSAAELHDFLTAHSRTPVPQPLSYLVDDVARKHGRLRIGAAGAYLRCDDDALLAEIVADRRAAELRLRHLAPTVLVSPTPPDVLLARLREMGYAPAAESPDGAVLVARAAAHRTPPRTPPAPVPDGPPAPDTALLAAAVRAVRAGDRAATAPLRAPQTPQDPRAAETPRAPDAPQTQAPGGLPRTPSAETLAVLQAAVLGNAAVWIGYVNADGAASQRVIAPVRVEGGYVTAYDHTADEVRSYPLHRITGAAELADDPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8N3</accession>
    <name>A0A0F7N8N3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_21880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017663.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_21880"/>
    <dbReference type="EnsemblBacteria" id="AKH84401">
        <property type="protein sequence ID" value="AKH84401"/>
        <property type="gene ID" value="AA958_21880"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_21880"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4608"/>
    <dbReference type="OrthoDB" id="1869451at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH84401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="89" mass="9487" checksum="9655F8670CAC52C9" modified="2015-07-22" version="1">MDTRWEADPAAAFARRLGKSSHELGQTSGDASCPDVWELENGDVAVIGTDLTTDYHGRLPEGVSVDPGERLVVIPRATVIAAKADIPDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8N8</accession>
    <name>A0A0F7N8N8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 10">Threonine synthase</fullName>
            <ecNumber evidence="6 10">4.2.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">AA958_24785</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 10">Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>H2O + O-phospho-L-homoserine = L-threonine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10840"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57590"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="EC" id="4.2.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 10 11">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 10">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 10">Belongs to the threonine synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.1" evidence="6 10"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018137.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_24785"/>
    <dbReference type="EnsemblBacteria" id="AKH84885">
        <property type="protein sequence ID" value="AKH84885"/>
        <property type="gene ID" value="AA958_24785"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_24785"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5226"/>
    <dbReference type="OrthoDB" id="428821at2"/>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004795">
        <property type="term" value="F:threonine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004450">
        <property type="entry name" value="Thr_synthase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026260">
        <property type="entry name" value="Thr_Synthase_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038945">
        <property type="entry name" value="Thr_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00260">
        <property type="entry name" value="thrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 10 11" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="PALP" evidence="13">
        <location>
            <begin position="28"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="11">
        <location>
            <begin position="190"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="12">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00018679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR038945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR038945-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR038945-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AKH84885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="359" mass="37363" checksum="6F2A6DE3B4E97981" modified="2015-07-22" version="1">MSGTRQWRGVIEEYRDRLPVTAGTPVVTLREGGTPLVPAQVLSARTGCDVHLKVEGANPTGSFKDRGMTMAISVAKESGAQAVICASTGNTSASAAAYAVRAGLTCAVLVPQGKIALGKMGQALVHGARILQVDGNFDDCLTLARALSEQYPVALVNSVNPVRIEGQKTAAFEVVDALGDAPDIHVLPVGNAGNITSYWKGYREYHDASSPQGALATHTPRMWGYQAAGAAPIVHGEPVKDPSTLATAIRIGNPASWELAERARDESGGHIEAVTDRQILRAYKLLAAQEGVFVEPASAASVAGLLQAAEQGRVDPGQRIVCTVTGNGLKDPDWAVAGAPQPVAVPVDADRAAERLGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8T9</accession>
    <name>A0A0F7N8T9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_22255</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017727.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_22255"/>
    <dbReference type="EnsemblBacteria" id="AKH84466">
        <property type="protein sequence ID" value="AKH84466"/>
        <property type="gene ID" value="AA958_22255"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_22255"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4687"/>
    <dbReference type="OrthoDB" id="975147at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16913">
        <property type="entry name" value="YkuD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041280">
        <property type="entry name" value="Big_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005490">
        <property type="entry name" value="LD_TPept_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038063">
        <property type="entry name" value="Transpep_catalytic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17964">
        <property type="entry name" value="Big_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03734">
        <property type="entry name" value="YkuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141523">
        <property type="entry name" value="SSF141523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519318" evidence="5">
        <location>
            <begin position="43"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="Big_10" evidence="7">
        <location>
            <begin position="73"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="YkuD" evidence="6">
        <location>
            <begin position="258"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="43"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH84466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="422" mass="44586" checksum="873FE0F8C61E4FCE" modified="2015-07-22" version="1">MAPFAVKGSYDVRVYGRGGVALTALAMSAVLGLTACGGDSSAEGSDDQKDSASEQKKNVPDARITIAPKDGTENVGINSDTKVTVKGGKLTEVVLTAAGSTDQVAGTIADDGSSWTPDAALERGTEYRLTAKAKDSDGQVSTSNANFSTVSAENSVIGYFTPEDGTEVGVGMPVSLNFDKPVEDKAAVESKIAVETSSGQEVVGHWFNDTRLDFRPEDYWEAGSTVTMDMNLDGVEASPGVFGVQDREMSFTVGRSQVTTVDVKAMTMEVVRDGKKIKTIPISAGSPENPTYNGQMVISEKHKETRMDGSTVGFTDDEGESEYDIPDVPHAMRLSTSGTFIHGNYWGGRGVFGSANTSHGCVGLFDKQGANDSGTDGAWFYDQSLVGDVVIVKNSPDETIAPDNGLNGWNMDWAAWQEGSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8Y1</accession>
    <name>A0A0F7N8Y1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_18590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017176.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_18590"/>
    <dbReference type="EnsemblBacteria" id="AKH83879">
        <property type="protein sequence ID" value="AKH83879"/>
        <property type="gene ID" value="AA958_18590"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_18590"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3900"/>
    <dbReference type="OrthoDB" id="1186918at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006764">
        <property type="entry name" value="SAM_dep_MeTrfase_SAV2177_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04672">
        <property type="entry name" value="Methyltransf_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017393">
        <property type="entry name" value="MTase_SAV2177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH83879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="264" mass="29078" checksum="14C913648FE10A93" modified="2015-07-22" version="1">MATEGFRFEEIDVSRPHPARIYDYLLGGKDNYEVDRQAGEQLVAAAPEARIGLRANRAFLQRAVRHVVADGIRQILDIGTGLPTAPNVHETAQETAPETRVVYVDNDPIVRAHADALLSQAGATSIVQADVRDVRSILDHPDVRRVLDFDEPVAVFLVAVLHFLTDADRPREIVAALRDALPSGSFLVLSHATGDFADRTDAQAVYDKATAGLNLRTYAEIEPFFDGFGLVEPGLVQVPFWRPDMPPPERYQEIGIYAGVGRKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N927</accession>
    <name>A0A0F7N927_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Purine phosphorylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_14540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016562.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_14540"/>
    <dbReference type="EnsemblBacteria" id="AKH83247">
        <property type="protein sequence ID" value="AKH83247"/>
        <property type="gene ID" value="AA958_14540"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_14540"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3061"/>
    <dbReference type="OrthoDB" id="1860206at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNP_UDP_1" evidence="1">
        <location>
            <begin position="6"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="387" mass="41112" checksum="2DD57B1B89F032E4" modified="2015-07-22" version="1">MPKDLVVILTALNLEYQAVRRKLTDPQAHRHERGTRFEVGTVQGTSCRVALGLTNKGNHSAAVIAERAIQEFSPVAVLFVGVAGALGDAARLGDVVMATHVYAYHGGTSEDDGLKARPRVWEAAHGISQLGSHLARVDDWADDRSGHGRTPQVRFGAIAAGEVVQNSTISAEARWIRQHYNDALAIEMEAAGVAQAGHLNGAPVAVIRGISDRADGTKNSAKDRNWQPRAAANAAAFAARLAVELMGEQEQIAMSQADGAHTADRLKEHVSNTAHNSTVGIMAGSVKESSVYLNADPKVTSPADLVEELDGFGEQLKRHHSEGVLDDDTYRAGVAELGLARRAARENTPESSKRATMALKRLRGLIAEFPELVTGLAPLVAAAGDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N944</accession>
    <name>A0A0F7N944_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">N-acetylglucosamine-6-phosphate deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AA958_19730</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="6">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the metallo-dependent hydrolases superfamily. NagA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017330.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_19730"/>
    <dbReference type="EnsemblBacteria" id="AKH84038">
        <property type="protein sequence ID" value="AKH84038"/>
        <property type="gene ID" value="AA958_19730"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_19730"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4158"/>
    <dbReference type="OrthoDB" id="1026967at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008448">
        <property type="term" value="F:N-acetylglucosamine-6-phosphate deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006044">
        <property type="term" value="P:N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00854">
        <property type="entry name" value="NagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003764">
        <property type="entry name" value="GlcNAc_6-P_deAcase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038994">
        <property type="entry name" value="NagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00221">
        <property type="entry name" value="nagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="8">
        <location>
            <begin position="74"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="238"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="327"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="4">
        <location>
            <position position="293"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR038994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR038994-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR038994-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR038994-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH84038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="405" mass="41499" checksum="6CD85851774532EB" modified="2015-07-22" version="1">MRDSMREGGTVLTGARVVQPAGTVEDARLTVADGRIASVAPQAGTARDGTAPQASGAVRDDGGPAALDLSGHWIVPGFVDIHVHGAGGASFSGGTHEQARTVIDTHRGHGTTTMLASTVTGDLDDLARQAGVLAELAEDGELAGIHFEGPFISPHRCGAHQPTLLRDPAPADVRKLVEAGRGQTRMLTLAPELPGGLDSVRLLADSGVIAAVGHTDSSYDAVQRAVAAGATVATHLFNAMPALGHRSPGPVAALLEDERVTVELINDGVHLHPAVLQLAFRTAGAGRVAFITDAMGAAGMGDGRYPLGPMEVDVRDGVARLVDGGSIAGSTLTLDTAFRRAVTVDRLPVGDAVAALSATPAKVLGAYDRIGSLEPGKDADLVVLDDRFTLVGIMRKGAWIVEPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N964</accession>
    <name>A0A0F7N964_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L32</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpmF</name>
        <name evidence="6" type="ORF">AA958_25840</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL32 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018844671.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_25840"/>
    <dbReference type="EnsemblBacteria" id="AKH85075">
        <property type="protein sequence ID" value="AKH85075"/>
        <property type="gene ID" value="AA958_25840"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_25840"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5442"/>
    <dbReference type="OrthoDB" id="2092354at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
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        <property type="evidence" value="ECO:0007669"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00008560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH85075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="57" mass="6695" checksum="E87E0332088A18F2" modified="2015-07-22" version="1">MAVPKRKMSRSNTRHRRSQWKAAVPHLVACERCHEPKQQHIACPNCGTYNRRQVLEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9D2</accession>
    <name>A0A0F7N9D2_9ACTN</name>
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        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">AA958_20250</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">CNQ-509</strain>
        </source>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
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            <end position="31"/>
        </location>
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        <location>
            <begin position="43"/>
            <end position="67"/>
        </location>
    </feature>
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            <begin position="255"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH84128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="447" mass="48374" checksum="122ED03B4B490ADE" modified="2015-07-22" version="1">MNRTHRILITVVVLGAVVIAAIGFAGSYAAVRDLAEEKGFGDFAVFFPIGIDAGIVVLLALDLLLTWIRIPFPLLRQTAWLLTAATIAFNGAAAWPDPLGVGMHAIIPVLFVVAVEAARHAIGRIADITADKYMEGVRVSRWLLAFPSTFRLWRRMKLWELRSYEEVIRLEQDRMVYRARLRARYGRAWRRKAPVEAVMPLKLARYGVPLAETAQAGLAAAGIDAPLRPAGSAARTAHALEPAQDVQTDQIAQNAQTAQAVPPVQTAPPAQVAYRPAAAAPQAQPAPPATATSPVPVPEPEPLPAPEPVATIPGPAPRRDLRAPAAVNGHQRAAAQRAPAAVPPPREPEPEPEPEPAPEPVAPPVPADDSAEVVGLPDGVPYDDALFGFYRQYVVDEGRFPSARVFARYLRDVHGVQYADGRTLGERYLRTYTHELKARYNQGMGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9K1</accession>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_20695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AKH84208">
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        <property type="gene ID" value="AA958_20695"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_20695"/>
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    <dbReference type="OrthoDB" id="1616572at2"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="7"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="292" mass="30162" checksum="072D9CE570239009" modified="2015-07-22" version="1">MKITVTGATGHLGRHVIAALLEQVPAERVAAVVRGREKAADLAARGVEVRVADYDEPATLADAFRAGERVLFVSGNAVGRRVPQHRAVVDAAAAARVGLLAYTGILGGPKADFLLGDEHKATEQLVLDSGLPYVFLRNGWYHEVHTDQLATVLDHGAVLGSAGAGRIASAARADYAAAAAAVLTGEGHEGRAYELSGDTAWSFPEYAAEVARQSGARVGYRDLPPAEHRQVLLGAGLPEAMADMLVDVDAAVSRGLLAGTSGELSRLIGRPTTPLADAVAAGLATVSATGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAF9</accession>
    <name>A0A0F7NAF9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DSBA oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_25635</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018291.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_25635"/>
    <dbReference type="EnsemblBacteria" id="AKH85041">
        <property type="protein sequence ID" value="AKH85041"/>
        <property type="gene ID" value="AA958_25635"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_25635"/>
    <dbReference type="OrthoDB" id="1108236at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="271"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="307"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="337"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="367"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="411"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="448"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="15"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="474"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH85041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="543" mass="54022" checksum="949D2074F2FEF236" modified="2015-07-22" version="1">MNATDAPQDRSRWFALAILCTGALMIVLDGSIVTVALPAIQEDLGFSPADLTWTVNAYMIAFGGLLLLAGRLGDLLGRKRVFVAGIALFTAASLLCGVATEPWALIAARFLQGVGGALASAVGLGMIVTLFTDAKERAKAIGAFAFTGAVGASLGQVLGGLLTDALSWHWIFFINVPIGLATAALALRVLPGDRGIGLAAGADVAGALLVTSGLMLGVYTIVETESHGWASGRTLGSAALAAALLAGFVLRQARAAAPLLPLRVFRSRTVAGANAVQLLVISGMFAFQIIVALYMQQVLGYGAAETGLAMLPAALTIGVTSLLVSARLVARFGERSVLLAGLVLLAAGLALLVRLPRDPAEVSYAAHLLPTMLLLSGGGLVLPAMTALGMSGAREDDAGVVSGLFNTGQQMGGALGVAVLTTLAAGRTESLAAAGEGRDAALTGGFQLAFGIGAVLVAAAAVLTVAVLRPRTAGGPGQPGAGAGAAGAEGPAADAAGAESPGATGAGAGSGAAPAPGATPAARLRLAADRRRTRRPAPATTPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAQ3</accession>
    <name>A0A0F7NAQ3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Fumarate hydratase class I</fullName>
            <ecNumber evidence="10">4.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">AA958_22665</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the reversible hydration of fumarate to (S)-malate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>(S)-malate = fumarate + H2O</text>
            <dbReference type="Rhea" id="RHEA:12460"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="EC" id="4.2.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 10">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4 10">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the class-I fumarase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.2" evidence="10"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017797.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_22665"/>
    <dbReference type="EnsemblBacteria" id="AKH84539">
        <property type="protein sequence ID" value="AKH84539"/>
        <property type="gene ID" value="AA958_22665"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_22665"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4768"/>
    <dbReference type="OrthoDB" id="1627779at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004333">
        <property type="term" value="F:fumarate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006091">
        <property type="term" value="P:generation of precursor metabolites and energy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004646">
        <property type="entry name" value="Fe-S_hydro-lyase_TtdA-typ_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004647">
        <property type="entry name" value="Fe-S_hydro-lyase_TtdB-typ_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036660">
        <property type="entry name" value="Fe-S_hydroAse_TtdB_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011167">
        <property type="entry name" value="Fe_dep_fumarate_hydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05681">
        <property type="entry name" value="Fumerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05683">
        <property type="entry name" value="Fumerase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001394">
        <property type="entry name" value="Fe_dep_fumar_hy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117457">
        <property type="entry name" value="SSF117457"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00722">
        <property type="entry name" value="ttdA_fumA_fumB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00723">
        <property type="entry name" value="ttdB_fumA_fumB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 10" id="KW-0408">Iron</keyword>
    <keyword evidence="8 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumerase" evidence="11">
        <location>
            <begin position="57"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="Fumerase_C" evidence="12">
        <location>
            <begin position="338"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR001394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF05683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AKH84539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="569" mass="61131" checksum="0A52B8552D541150" modified="2015-07-22" version="1">MTATARPASPAFQYTDLLPLGADTTAYRLLTKEGVRTVEAGGRTFLEVDPEALRLLAAEAMHDISHYLRPAHLAQLRAICDDPEASANDKFVALDLLKNANISAAGVLPMCQDTGTAIVMGKRGQQVLTAGGDEEALSRGVYDAYTKLNLRYSQMAPLTMWDEKNTGNNLPAQVELYATDGDAYKFLFMAKGGGSANKSFLYQETKAVLNEASMLRFLEEKIRSLGTAACPPYHLAIVVGGTSAEYALKTAKYASAHYLDSLPTEGSPAGHGFRDTELEAKVFELTQTLGIGAQFGGKYFCHDVRVVRLPRHGASCPVAIAVSCSADRQALAKITAEGVFLEQLEHDPARFLPDTTAAELTAGSAAAMDEAVRIDLARPMAEVRAELTKYPVKTRLSLTGPLVVARDIAHAKIKERLDAGEEMPQYLKDHPVYYAGPAKTPEGYASGSFGPTTAGRMDAYVEQFQAAGGSMVMLAKGNRSQQVTDACAAHGGFYLGSIGGPAARLAQDCIKKVEVLEYEELGMEAVWKIEVEDFPAFIVVDDKGNDFFTDPGPVKPFVTSIPVRGAAQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NB90</accession>
    <name>A0A0F7NB90_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_30120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018998.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH85770">
        <property type="protein sequence ID" value="AKH85770"/>
        <property type="gene ID" value="AA958_30120"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_30120"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6360"/>
    <dbReference type="OrthoDB" id="1874901at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015057">
        <property type="entry name" value="Rv2632c-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038070">
        <property type="entry name" value="Rv2632c-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08962">
        <property type="entry name" value="DUF1876"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143212">
        <property type="entry name" value="SSF143212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="98" mass="10383" checksum="A4843B1EEEA53ADA" modified="2015-07-22" version="1">MTHTVKWNVSLQLFEEAGTTTARVVLDTAAGRFTGHGDARRNPADPDVPEIGDELAAGRALDDLGRQLVDVARRDVEAIEATGPSAGSGDGWPSPDRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBG6</accession>
    <name>A0A0F7NBG6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Threonine synthase</fullName>
            <ecNumber evidence="7">4.2.3.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_19780</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the threonine synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.1" evidence="7"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017339.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_19780"/>
    <dbReference type="EnsemblBacteria" id="AKH84047">
        <property type="protein sequence ID" value="AKH84047"/>
        <property type="gene ID" value="AA958_19780"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_19780"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4168"/>
    <dbReference type="OrthoDB" id="428821at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004795">
        <property type="term" value="F:threonine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901607">
        <property type="term" value="P:alpha-amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004450">
        <property type="entry name" value="Thr_synthase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00260">
        <property type="entry name" value="thrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PALP" evidence="6">
        <location>
            <begin position="98"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="5">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR604450-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH84047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="434" mass="44965" checksum="558F3AE18B3FD255" modified="2015-07-22" version="1">MAVDTAPTPTAVDGGPDLGPAVALSCRECGERVPLGPVFACQSCFGPLEAAYELPGGDAGSAARLRARIEAGPRSIWRYAPLLPVPADVAGKPNLNPGFTRLHRADRLAAELGVTGALHVKDDSGNPTHSFKDRVVAIAVEAARAFGFTTLSCSSTGNLAGAVGAAAARAGLRSCVFIPYDLEHAKVVMAAVYGGDVVGIEGTYDDVNRFCSELIGDPIGEGWGFTNVNLRPYYAEGSKTLAYEICEQLGWRLPDNIVIPVASGSQLTKIDKGLKELIATGLVEERPYKIFGAQAAGCSPVSRAFKDGHDVVRPVRPDTIAKSLAIGNPADGPYVLDIARRTGGAVEDVTDAEVVDAVKLLARTEGVFAETAGGVTFGVLAKLVTDGRIDPAGTTVAINTGDGLKTLDAVAPTTGPSAIIRPTLDSFREAGLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBY5</accession>
    <name>A0A0F7NBY5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fe-ADH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_29780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018949.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_29780"/>
    <dbReference type="EnsemblBacteria" id="AKH85721">
        <property type="protein sequence ID" value="AKH85721"/>
        <property type="gene ID" value="AA958_29780"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_29780"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6287"/>
    <dbReference type="OrthoDB" id="1456634at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001670">
        <property type="entry name" value="ADH_Fe/GldA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018211">
        <property type="entry name" value="ADH_Fe_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039697">
        <property type="entry name" value="Alcohol_dehydrogenase_Fe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496">
        <property type="entry name" value="PTHR11496"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00465">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00913">
        <property type="entry name" value="ADH_IRON_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe-ADH" evidence="2">
        <location>
            <begin position="10"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH85721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="400" mass="40927" checksum="6C3777F5DB1E939B" modified="2015-07-22" version="1">MDDFAILRTPAQVIFGTGMASATGSLAAEYGDRALVVTDPNIAGSPGFNSVRTSLHEAGVDVRVFSEAVVDVPESTITEAVGYAAEYRPDVVVAVGGGSTIDLAKVTALLARHPGPLSTYYPVGSVPGPVLPLIAVPTTAGTGSEVTPVSVITDATTRMKVGIASRHLIPRHALCDPLLTVGAPRTVTAHSGMDALAHAVESFMAIRRPAAPSSVLSRPQVGKNPLSDTLALAAAGGICANLARAVDDGDDLEARSAMLYGSLLAGIAFGNAGVTAGHALQFAVGAATHTSHGLGTGLLLPYVMEFNRPARLAEMAALAEAMACTDPVAAVHELGLRVGLPASLAEIGVEAGEVRGLAEASIGIRRLIDNNPVRLDVDALEQILTAAWHGEPDRISAARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NC20</accession>
    <name>A0A0F7NC20_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Extracellular small neutral protease</fullName>
            <ecNumber evidence="4 6">3.4.24.77</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AA958_25335</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>Hydrolyzes proteins with a preference for Tyr or Phe in the P1' position. Has no action on amino-acid p-nitroanilides.</text>
            <dbReference type="EC" id="3.4.24.77"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 6">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the peptidase M7 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.77" evidence="4 6"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018235.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH84984">
        <property type="protein sequence ID" value="AKH84984"/>
        <property type="gene ID" value="AA958_25335"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_25335"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5339"/>
    <dbReference type="OrthoDB" id="1649119at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000013">
        <property type="entry name" value="Peptidase_M7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02031">
        <property type="entry name" value="Peptidase_M7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016573">
        <property type="entry name" value="Peptidase_M7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00787">
        <property type="entry name" value="NEUTRALPTASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="6 8" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014495126" description="Extracellular small neutral protease" evidence="6">
        <location>
            <begin position="29"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="26"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="178"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR016573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR016573-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR016573-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR016573-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AKH84984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="209" mass="22457" checksum="B68CE3C793FF46A8" modified="2015-07-22" version="1">MKLSGRLVSTALGLGLALTGLAASPAPAADHHDRQTTQATASAAYVGQDKEQQKENRAFFEMIREKAREKQAAEPGYQAITITYNDAGAPNYQGDIAQSTQIWNNATNNITLAETSGSGDFTYRQGNDPRGSHAVTDGRGHGYVFLDLRQTQQYYSLRVVTHETGHILGLPDNYSGPCSELMSGGGPGTSCRNAYPNADEAARVDRNFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NC47</accession>
    <name>A0A0F7NC47_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Luciferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_21150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017561.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_21150"/>
    <dbReference type="EnsemblBacteria" id="AKH84282">
        <property type="protein sequence ID" value="AKH84282"/>
        <property type="gene ID" value="AA958_21150"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_21150"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4454"/>
    <dbReference type="OrthoDB" id="1434838at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="14"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="289" mass="31937" checksum="4F95322B5B857219" modified="2015-07-22" version="1">MRFSANIPNFGDFADPRNVVAVATAAEQAGWDGLFVWDHVLHRRHLGRPFGDPWMLLTAAALATDRIRLGTLLTPVPRYLPQQLARQVATLDQLSGGRVIFGAGLGGPIEDEYRSFGDTAEPRVLGERLDEGLELLQSFWSGEPVTHRGRHFEAQDVTLLPATAQQPRPPVWIGGFWPRRPPMRRAARWDGAVPLFESARHGYVPDLAEVRDLFAYVREHRAAAGAEGPFEYVLGGATPPDPAKARDIVGPLRDEGATWWDERQVQTGPELDSLPAVLRRVEAGPPVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCB5</accession>
    <name>A0A0F7NCB5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">IclR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_25725</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018299.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_25725"/>
    <dbReference type="EnsemblBacteria" id="AKH85053">
        <property type="protein sequence ID" value="AKH85053"/>
        <property type="gene ID" value="AA958_25725"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_25725"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5419"/>
    <dbReference type="OrthoDB" id="370329at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
            <begin position="7"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="4">
        <location>
            <begin position="67"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH85053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="238" mass="24882" checksum="48326B47311BE838" modified="2015-07-22" version="1">MDNSSGVGVLDKAAVVLSALESGPATLAGLVSATGLARPTAHRLAVALEHHRMVARDMQGRFILGPRLAELAAAAGEDRLLAAAGPVLTHLRDVTGESAQLYRRQGDMRICVAAAERLSGLRDTVPVGSTLPMKAGSAAQVLLAWEEPERLHRGLQGARFTATALSGVRRRAWAQSVGEREPGVASVSAPVRGPSNRVVAAVSVSGPIERLTRHPGRMHAQAVVDAAARLTDALRRTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCG8</accession>
    <name>A0A0F7NCG8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Uridylate kinase</fullName>
            <shortName evidence="6">UK</shortName>
            <ecNumber evidence="6">2.7.4.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Uridine monophosphate kinase</fullName>
            <shortName evidence="6">UMP kinase</shortName>
            <shortName evidence="6">UMPK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">pyrH</name>
        <name evidence="9" type="ORF">AA958_26010</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible phosphorylation of UMP to UDP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>ATP + UMP = ADP + UDP</text>
            <dbReference type="Rhea" id="RHEA:24400"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.22"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="6">Inhibited by UTP.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; UDP from UMP (UMPK route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the UMP kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.22" evidence="6"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018344.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_26010"/>
    <dbReference type="EnsemblBacteria" id="AKH85103">
        <property type="protein sequence ID" value="AKH85103"/>
        <property type="gene ID" value="AA958_26010"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_26010"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5477"/>
    <dbReference type="OrthoDB" id="1043239at2"/>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033862">
        <property type="term" value="F:UMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044210">
        <property type="term" value="P:'de novo' CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04254">
        <property type="entry name" value="AAK_UMPK-PyrH-Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01220_B">
        <property type="entry name" value="PyrH_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011817">
        <property type="entry name" value="Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015963">
        <property type="entry name" value="Uridylate_kinase_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005650">
        <property type="entry name" value="Uridylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02075">
        <property type="entry name" value="pyrH_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 6" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AA_kinase" evidence="8">
        <location>
            <begin position="27"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="31"/>
            <end position="34"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>UMP</name>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>UMP</name>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="154"/>
            <end position="161"/>
        </location>
        <ligand>
            <name>UMP</name>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH85103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="263" mass="28432" checksum="69013038F4BFE6C8" modified="2015-07-22" version="1">MNEDADADHGHREKADNGHHTKRDSSRFLLKLSGEAFSGGGDLGVDPDVVRAIAREVAAVVRDGYEIAVVIGGGNFFRGAELQQRGMDRARSDYMGMLGTVMNCLALQDFLEKEGIDSRVQTAITMGQVAEPYIPLRAIRHMQKGRVVIFGAGMGMPYFSTDTTAAQRALEIHAEALLMGKNGVDGVYDSDPKKNPDAVKFDALGYGEVITRDLKVADATAVTLCRDNELPILVFELLKEGNIARAVRGEKIGTLVSAHGSRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCP5</accession>
    <name>A0A0F7NCP5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin)</fullName>
            <ecNumber evidence="4">1.17.7.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ispG</name>
        <name evidence="5" type="ORF">AA958_26255</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + H2O + oxidized [flavodoxin] = 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + reduced [flavodoxin]</text>
            <dbReference type="Rhea" id="RHEA:43604"/>
            <dbReference type="Rhea" id="RHEA-COMP:10622"/>
            <dbReference type="Rhea" id="RHEA-COMP:10623"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:58483"/>
            <dbReference type="ChEBI" id="CHEBI:128753"/>
            <dbReference type="EC" id="1.17.7.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="4">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 5/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the IspG family.</text>
    </comment>
    <dbReference type="EC" id="1.17.7.3" evidence="4"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018389.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_26255"/>
    <dbReference type="EnsemblBacteria" id="AKH85148">
        <property type="protein sequence ID" value="AKH85148"/>
        <property type="gene ID" value="AA958_26255"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_26255"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5527"/>
    <dbReference type="OrthoDB" id="665306at2"/>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00096"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046429">
        <property type="term" value="F:4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00159">
        <property type="entry name" value="IspG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016425">
        <property type="entry name" value="IspG_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004588">
        <property type="entry name" value="IspG_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30454">
        <property type="entry name" value="PTHR30454"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04551">
        <property type="entry name" value="GcpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004640">
        <property type="entry name" value="IspG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="SSF51717"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56014">
        <property type="entry name" value="SSF56014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00612">
        <property type="entry name" value="ispG_gcpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 4" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH85148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="384" mass="40206" checksum="26F3C42F67A3D89A" modified="2015-07-22" version="1">MTAVSLGMPSVPLKMAERRASRTLHVGSVAVGGDAPVSVQSMTTTRTSDIGATLQQIAELTASGCQIVRVACPTQDDADALPVIAGKSQIPVIADIHFQPKYVYAAIDAGCAAVRVNPGNIKKFDDQVKQIARAASAAGTPIRIGVNAGSLDRRLLAKYGKATPEALVESALWECSLFEEYGFTDIKISVKHNDPVVMVNAYRQLAAQCDYPLHLGVTEAGPAFQGTIKSAVAFGALLGEGIGDTIRVSLSAPPVEEVKVGIQILESLGLRERRLEIVSCPSCGRAQVDVYKLADEVTAGLDGMEVPLRVAVMGCVVNGPGEAREADLGVASGNGKGQIFVKGEVIKTVPESKIVETLIEEAMKIADRMEADGTAAGEPEVTVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCP6</accession>
    <name>A0A0F7NCP6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_22365</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017748.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH84487">
        <property type="protein sequence ID" value="AKH84487"/>
        <property type="gene ID" value="AA958_22365"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_22365"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4709"/>
    <dbReference type="OrthoDB" id="1926714at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043215">
        <property type="term" value="P:daunorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900753">
        <property type="term" value="P:doxorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005894">
        <property type="entry name" value="DrrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025302">
        <property type="entry name" value="DUF4162"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13732">
        <property type="entry name" value="DUF4162"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01188">
        <property type="entry name" value="drrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="5"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="316"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH84487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="339" mass="36133" checksum="75B96B0FD77B3085" modified="2015-07-22" version="1">MPGAIHAEGLVKHFGDVRALDGVDLDVPEGSVLGLLGPNGAGKTTAVRVLTTLLRPDAGRAEVAGIDVLKHPNEVRRSIGLSGQFAAVDEYLTGRENLQMVGQLYQLSSRDAKARAGVLLERFNLADAADRTAKTYSGGMRRRLDLAAALVVEPPVMFMDEPTTGLDPRNRQQLWDVIQELVKGGTTLLLTTQYLEEADHLAHDICVIDHGRVIARGTSDELKARTGGERVEVVVHQRDQIFAASEVLGALGQGEVTVADHTRKLTVPVSGGARLLADVIRDLDERGIAIDDIGLRRPTLDDVFISLTGHVAEAEDGDGKAIEDGGPGAAADAAKETDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-12-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCT3</accession>
    <name>A0A0F7NCT3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Alkyl hydroperoxide reductase AhpD</fullName>
            <ecNumber evidence="6">1.11.1.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Alkylhydroperoxidase AhpD</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ahpD</name>
        <name evidence="8" type="ORF">AA958_22605</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(R)-N(6)-dihydrolipoyl-L-lysyl-[lipoyl-carrier protein] + a hydroperoxide = (R)-N(6)-lipoyl-L-lysyl-[lipoyl-carrier protein] + an alcohol + H2O</text>
            <dbReference type="Rhea" id="RHEA:62636"/>
            <dbReference type="Rhea" id="RHEA-COMP:10502"/>
            <dbReference type="Rhea" id="RHEA-COMP:16355"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="1.11.1.28"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the AhpD family.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.28" evidence="6"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017785.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH84527">
        <property type="protein sequence ID" value="AKH84527"/>
        <property type="gene ID" value="AA958_22605"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_22605"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4756"/>
    <dbReference type="OrthoDB" id="1427837at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008785">
        <property type="term" value="F:alkyl hydroperoxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032843">
        <property type="term" value="F:hydroperoxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01676">
        <property type="entry name" value="AhpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004674">
        <property type="entry name" value="AhpD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004675">
        <property type="entry name" value="AhpD_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00777">
        <property type="entry name" value="ahpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00778">
        <property type="entry name" value="ahpD_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="4 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1 6" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="5 6" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMD" evidence="7">
        <location>
            <begin position="94"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="6">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="131"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Interchain (with AhpC); in linked form" evidence="6">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH84527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="177" mass="18407" checksum="6FC4D856393187EE" modified="2015-07-22" version="1">MALDALKSALPGYAGDLRRNLTSVVDDGRLPERQLWGALLACAIAVRSAPLLRAVAPEARRRLTPEAYGAAGAAAAAMAANNVFFRARHLLSDPGYGHLRTGLRTNVLGARGVPKADYELWCVAVSAVGGCGACLDEHEAALRRTGADRETVQEALKVAALVHAAGTVLDAQEALGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDA3</accession>
    <name>A0A0F7NDA3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_00590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019679.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86465">
        <property type="protein sequence ID" value="AKH86465"/>
        <property type="gene ID" value="AA958_00590"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_00590"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.138"/>
    <dbReference type="OrthoDB" id="1278667at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH86465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="151" mass="16280" checksum="AAF0D05ECA047C42" modified="2015-07-22" version="1">MGTSETGGAYEGFSAEERAAMKEYAQERKKAARRGSKADKAAEAVRDVLAKIAEMDDSDRVMAERIHAVVTATAPELAPKTWYGMPAYARDGKVVCFFQSAGKFNARYATLGFSDLANLDEGTMWAAGFALTEVTDEVEARIAALVKQAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDY7</accession>
    <name>A0A0F7NDY7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nitrate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
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        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">CNQ-509</strain>
        </source>
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            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
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</entry>
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                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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</entry>
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                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">CNQ-509</strain>
        </source>
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    </dbReference>
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            <dbReference type="EMBL" id="AKH84977.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="145" mass="15259" checksum="9A88D2A48D596ECC" modified="2015-07-22" version="1">MLRDLALTAPERLLAAALDGSLDAELRALWRQAGAGLPPGEQSDDRPVGRLVRHDSVLVTLPPAVAPPEAHFVLVTAPPGAPVRYATLEASPGPAGRPAAMLCMWAMTAEGPAHASTLQFLPPREDRFLDAAMELPSVPPTFALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NE67</accession>
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    <reference evidence="3 4" key="1">
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                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
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    <dbReference type="EnsemblBacteria" id="AKH86760">
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    </dbReference>
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            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH86760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="168" mass="17368" checksum="021D19E8C8B93B56" modified="2015-07-22" version="1">MTAKGGTAQDGAGPEPGADAHLDTQQSLGQLVSTATTNLSALLHDEIALLKAETREDIKRAGAGGAALGVAAVLVLFGIPVLSFAAAYGLHALGLHLAWSFLIVFGVHLVLGALAALWGIAKMRQMRKPERAMNSTKETATVISDSLRGRGHPADRRKPAAGVARSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NEF3</accession>
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                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="OrthoDB" id="710201at2"/>
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        <location>
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            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="507" mass="55065" checksum="7911497CCE9C3334" modified="2015-07-22" version="1">MGALELDGTGGSRTGATGAGKGPNGELTSWFLRSGWSKGELARQVNRRARQLGAHHISTDTSRVRRWLDGEQPREPIPRILSDLFSERFGRVVGVDQLGLHAARPRPAVSGIDLPWNATETVEHISEFSRSDLMLARRGFLGTSLNVAAGPVLVEPMQRWLAHPPGPGGPAAPVPASAAASAAPAGVPPYALSGPELALLETTTAKFRQWDAQCGGGLRRKAVVGQLHEITDLLQEPYAPAVAERLFRITAELSQLAGWMSYDVGLQPTAQKYFVLALHAAKEAGDRPLGAYVLSSMARQMIHLGRADDALELIHLAQYGSRDSATARTQSMLYAMEARAYANLGRPDRCHRAVRMAQDCFEEIDPDGSEPDWIRFFSEAELNSENAHSYRDLAYVAGRSPTYAALARPVMARAVELFAADAERRRSYALNLVGLATVHLLEEDPRQCALCAGEALTVARQVRSERVNTRLRKTVDTAVRRYGAVGEVADLADRLARELPETVEAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NEG4</accession>
    <name>A0A0F7NEG4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UPF0102 protein AA958_25970</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_25970</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the UPF0102 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018338.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_25970"/>
    <dbReference type="EnsemblBacteria" id="AKH85097">
        <property type="protein sequence ID" value="AKH85097"/>
        <property type="gene ID" value="AA958_25970"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_25970"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5468"/>
    <dbReference type="OrthoDB" id="2044249at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00048">
        <property type="entry name" value="UPF0102"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003509">
        <property type="entry name" value="UPF0102"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34039">
        <property type="entry name" value="PTHR34039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02021">
        <property type="entry name" value="UPF0102"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH85097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="120" mass="13035" checksum="804FA85A408F4A6C" modified="2015-07-22" version="1">MPKQRQALGQYGERIAERRLVQAGMTVLARNWRCSDGEIDIVALDGEALVVCEVKTRREGGWEHPMAGVPPAKADRLRRLAEAWALRHGGVPPGGMRIDVVGVVLPDRGAPVVEHVRGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NEG9</accession>
    <name>A0A0F7NEG9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_30560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019067.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH85839">
        <property type="protein sequence ID" value="AKH85839"/>
        <property type="gene ID" value="AA958_30560"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_30560"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6458"/>
    <dbReference type="OrthoDB" id="1302474at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519559" evidence="1">
        <location>
            <begin position="32"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="188" mass="20849" checksum="B464CC78C03F7D4D" modified="2015-07-22" version="1">MRPLTRILTALAATAVLAFTAAACTDDSSQAQESRTKQSGYDRLVQRQPADAMRYSPTRETINKWVDNWEKPGKLSYVYLQNANGEYGYFVLEGLPVSYCAMLTPPEDVDSSQNGMVTKTAPGMDGVYYSGGQCSAYYGFDATTGAYMEFTIGSNQSFFLYDQPMTLPEFRDATPLGQTRIEDGKLQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NEM3</accession>
    <name>A0A0F7NEM3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_13055</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020014.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_13055"/>
    <dbReference type="EnsemblBacteria" id="AKH86731">
        <property type="protein sequence ID" value="AKH86731"/>
        <property type="gene ID" value="AA958_13055"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_13055"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2747"/>
    <dbReference type="OrthoDB" id="1571751at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519365" evidence="3">
        <location>
            <begin position="37"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH86731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="451" mass="47233" checksum="3656757C1B60664F" modified="2015-07-22" version="1">MPAGSARGPARFVRVVRLAALAALLLVLFPIPAAWAAPSPGEEIADRLRDSPVYVHDAYTGAVDEARQRAIAARIEETGLPVKVVLVPLAKGDDFAGDPGTLAEVVRGRLGDGDLILVTTSEQADWLQGFEWPGGTHQARDAVGAVGHLDEMNEAGLAARVEKAVELIDAGNGTEVYEEAVADLGTDSPPGTGADAGDGDAGDAEEKESGGGSAVPLALAAAAAVAVLAGLLWYVRRGRTGSRIGFSTGSRVATAPFATPQAVFAAARAADEAELRRRAEEEVVALGEAVREVATDTPDRATHLHAALDAYAAAGTVLDGAGSRADLAGVLALVAEGRDALEAARTTRPRRTTPLPLCFFNPLHGRATHRTRWRPLGSRRQLPVATCDTCTKALRERRAPEVLTDTTEGREVPYFEVPAESSIWAATGYGSLTRDPLAPRVARGDFTRTRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFB3</accession>
    <name>A0A0F7NFB3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_22080</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_22080"/>
    <dbReference type="EnsemblBacteria" id="AKH86961">
        <property type="protein sequence ID" value="AKH86961"/>
        <property type="gene ID" value="AA958_22080"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_22080"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4651"/>
    <dbReference type="OrthoDB" id="990666at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH86961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="295" mass="32164" checksum="CB74DD8421B62A35" modified="2015-07-22" version="1">MLAPRLAQFAAVAREEHVTRAARALGVPQPTLSRAMVRLEADLGVALFARRGRTLSLTTAGRDFLAYAERALAEVARGAEAVRADAHPETGKVAFGFLHTLGSETVPGLLREFRKDHPRVRFSLVQNYGEWMLQRLRAGELDLCLTSPVPDAPDLEGRRLDDQRLRIVVPDDHRLAGRRRIRLAEVAEDPFVTLEPGYGMRRMLEALCAEAGFVPRVAFEGEEAETIRGLVAAGLGVALLPPPAVPRPGVVELDVTAPRAVREIGVAWVAGQQETAPVGAFRRFLLGRRGQLLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFD8</accession>
    <name>A0A0F7NFD8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF3152 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_23395</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020352.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_23395"/>
    <dbReference type="EnsemblBacteria" id="AKH86986">
        <property type="protein sequence ID" value="AKH86986"/>
        <property type="gene ID" value="AA958_23395"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_23395"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4932"/>
    <dbReference type="OrthoDB" id="1478995at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022603">
        <property type="entry name" value="DUF3152"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11350">
        <property type="entry name" value="DUF3152"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3152" evidence="2">
        <location>
            <begin position="285"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH86986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="468" mass="48896" checksum="2D78B7119466AEF1" modified="2015-07-22" version="1">MPRFGDTGPVPRVSDTGPIPRAGGTGPIPRVSDTGPTPRVGDTGPTPRVAGPGGPPPVHGMPRPSRGPRTVPMDDTGERLPGHPEHREPGGGWGMPPYEQPGRGLGAATVAATPTPVRQDYLDAFDGPGPGQTADPAARRRPGDVPGPSPAADDLGRLPGDEEPPDDTAAALHSTGGGGRRRKQRPANRGRVVTGVAAAVVTCALAAAIAGQVSDGRAKRADAAASDERKQRAGADDDAASRSGDRDDPAGPDEPDGADAGEDARAVPATYTEKMAATYPLSRNLTGSGKLTTVPGHDKAPGRGEVVTYRVDVEDGLPLDGELFAAAVHKTLNDERSWGGRGDRTFERVGRDRESVFVITLASPGTTDEWCAKSGLDTSDEDVSCDSAATERVMINAFRWAQGSKTYGDDIHAYRQMLINHEVGHRLGNGHVGCERDGALAPVMMQQTKYLSTDGATCKPNPWPFPRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFF1</accession>
    <name>A0A0F7NFF1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoacyl-tRNA hydrolase</fullName>
            <ecNumber evidence="1">3.1.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_27890</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>an N-acyl-L-alpha-aminoacyl-tRNA + H2O = a tRNA + an N-acyl-L-amino acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54448"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:13883"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59874"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:138191"/>
            <dbReference type="EC" id="3.1.1.29"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.1.1.29" evidence="1"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018656.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_27890"/>
    <dbReference type="EnsemblBacteria" id="AKH85422">
        <property type="protein sequence ID" value="AKH85422"/>
        <property type="gene ID" value="AA958_27890"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_27890"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5879"/>
    <dbReference type="OrthoDB" id="2018338at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:aminoacyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023476">
        <property type="entry name" value="Pep_tRNA_hydro_II_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002833">
        <property type="entry name" value="PTH2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01981">
        <property type="entry name" value="PTH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102462">
        <property type="entry name" value="SSF102462"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00033690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH85422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="250" mass="26265" checksum="88B44DC72C334EA8" modified="2015-07-22" version="1">MTGTETSPFQHEAVSRDDLPQFVLPLVVRIERTGPPTRTDALQTAARAVLVLLADERSTGEGPWARAVRDWQDARIRKVVRRARGAEWRRAEALPGITVTSAAGGGAADGPAPGPGAAEVRVFPPVPLDGWPKDLARLQVSGTDLDDPEPPSPPPAGVPVLWLATGLGMTAGKAMAQAGHGAQLAWWELGDEERAAWRAAGFPLAVRTAAPEHWAELVASGLPVVRDAGYTEIAAGSCTVVADHPALRTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFI6</accession>
    <name>A0A0F7NFI6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_28135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018696.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_28135"/>
    <dbReference type="EnsemblBacteria" id="AKH85462">
        <property type="protein sequence ID" value="AKH85462"/>
        <property type="gene ID" value="AA958_28135"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_28135"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5930"/>
    <dbReference type="OrthoDB" id="1526822at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="34"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="186" mass="20479" checksum="E2E10BAFC67F8E51" modified="2015-07-22" version="1">MESSALTTWSLEQTAADDLTPAAAPATVAAGELTVVRAAVPSPGFSRYLYGAVGADVSWTDRLVWDEERWRAFVEQPGTETWVAYERGTPAGYLELEGQSDGVVEITYFGLLPAFRGRRVGGHLLSVGTARAWDLAERWPGRSPTRRVWVHTCSDDGPYALDNYRRRGFRVFGVRTEDRAAGGPQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFS4</accession>
    <name>A0A0F7NFS4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AMP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_32555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019395.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86168">
        <property type="protein sequence ID" value="AKH86168"/>
        <property type="gene ID" value="AA958_32555"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_32555"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6871"/>
    <dbReference type="OrthoDB" id="961884at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="40"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="519" mass="56541" checksum="CCE45B9688BD4391" modified="2015-07-22" version="1">MRLPQSADLLYGQLVALSGKAKRTWAADHTSAAVPVRDGEIDVGELAEATRRFARGVQAAGIAAEDWCVVRLEKPLDVLVAVCGLTAVGAVPVLLSPGLEADAAHTALKTVPHSMHLLVARARAEEFPDALAVDAARLVWEDIWEQDGEAGTATDALPQHGVERSPDSPYLVTHTSGTTGVPKLAVHTRASFYQQSVIQTRMLRLLRLRGYAAFATSPVHIRTLSALLTGITAGVSLLILGSEQRDSVREQLERWRPEYLETHPNTFVTWEDLADAGVMSSVRVFLATFDATHPRTVDRLLAGSRRRLAVFMEVYAQSEVGPIAFHVRTRRRRRAGVETELAGHRVGHAIPGYAAIRVVDENGTAVPRGQAGRIQVRAKGRFAGYLNFPEKFTQNLFEERWWDTGDWGSLGRGGTLRLLDRQVERLEGAPSGIALEDVLLSRIPDLAEVVVLETEEGLLPVIAGQPGAEPVGPEEWSAATGDMPALAAPLSVAWEEIPRTATGKVRREVLRGRLADMER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NG27</accession>
    <name>A0A0F7NG27_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_33785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019601.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_33785"/>
    <dbReference type="EnsemblBacteria" id="AKH86379">
        <property type="protein sequence ID" value="AKH86379"/>
        <property type="gene ID" value="AA958_33785"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_33785"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.7135"/>
    <dbReference type="OrthoDB" id="1582456at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="242" mass="24461" checksum="FFD9929B5DDE08CA" modified="2015-07-22" version="1">MTATARTGRVWFVTTAGHGAGRAVTATALARGDRVAAVVPDEAARDRLLARHEEHRRRLFVRALDVADNWSVNATVCAAADRFGRLDAIVNDARPPRPSPGGTAAGDAAAPVGWIPEPAARARMESAFFGPLWVAQAVLPLLYAQRSGHLLQLCGSVAPPGAPGTALDRAATCAVVALSRAAAGEAARAGVDISVVGGRPDAGALLRLVDGAAARRRDATAPAPDPASPSASASAAGHGAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NG44</accession>
    <name>A0A0F7NG44_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carbon-nitrogen hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_33325</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
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        <text evidence="1">Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.</text>
    </comment>
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AKH86298">
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    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_33325"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.7038"/>
    <dbReference type="OrthoDB" id="1583074at2"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="RamA-like"/>
    </dbReference>
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        <property type="entry name" value="UPF0012_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01227">
        <property type="entry name" value="UPF0012"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="4"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH86298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="262" mass="27732" checksum="03290BB1A4E97B20" modified="2015-07-22" version="1">MAPLRTALLQGPAGVPPSRREALAALEAAARTAAAGGARLLVASELFLSGYATDPAGRAEPADGPGACAVAGIAADHGLSIAYGYPERDGSDVYNAVQLVSPYGYPLANYRKTHLFGDFERKFFTAGDTPVVQADVDGIRVGILICYDVEFPEPVRAHALAGTELLLVPTALMRPYEFVPRALIPVRAYESQLYVAYVNRVGAEGEHHFAGLSCLAAPDGTVRARAGHDGEDLLLADADPARIAAARRDNTYLADLRPELYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NG97</accession>
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        <submittedName>
            <fullName evidence="3">Superoxide dismutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_00560</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000034283">
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        <property type="project" value="InterPro"/>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519472" evidence="1">
        <location>
            <begin position="24"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="Sod_Cu" evidence="2">
        <location>
            <begin position="74"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH86464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="189" mass="19596" checksum="E0E5BAF04D555865" modified="2015-07-22" version="1">MSAVPAAVALLVSGAAGPAPASAAQGEAPDVVAREAYFLPPENAEPDDGLTYDPALVPAGAGIGVAGVGRHGTTHLRLTLTGLIPDRTYGAHVHTRPCGSTPDEAGPHYQNEPDPVQPSVDPAYANPDNEVWLDFTTDLRGNAEATARQDWRFRPGEARSVVVHEHATTHPGEAGKTGARLACLSVPFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NGL7</accession>
    <name>A0A0F7NGL7_9ACTN</name>
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        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="4" type="ORF">AA958_34185</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
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            <taxon>Bacteria</taxon>
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    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH80833">
        <property type="protein sequence ID" value="AKH80833"/>
        <property type="gene ID" value="AA958_00075"/>
    </dbReference>
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        <property type="gene ID" value="AA958_34185"/>
    </dbReference>
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    <dbReference type="KEGG" id="strc:AA958_34185"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="613"/>
            <end position="643"/>
        </location>
    </feature>
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            <end position="245"/>
        </location>
    </feature>
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            <end position="398"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="434"/>
            <end position="468"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH80833.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AKH86438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="643" mass="71752" checksum="68C11ADF983779F7" modified="2015-07-22" version="1">MRLRIEELTLVGTSRTVRFEPGMNAIVGSMSGGKTATVSCLRALLGAEVNVVPELRGRTTSGTVLIGTRRFRIVRQLVSTSTAKVDIAEIGGEQEVWRLPASQLQAGYDQTFRDWWLSMLGLPRIRVPRALTDETSPLIPVTISDYLMYCVLRQKEIDTSVFGTPDNAQKNIKRKYVFEILYGLYDPEAAGMRERLRAVTTELNALTADATTLERILETTAFASRAQLEVQRQETEQQLIQARQADQVMARQLTHPATVSLREQIGEVEAELARISNAAAAEAVSVSRLEELRDQLIAQSRRLTRALVAERLLNDFEFHTCPRCGAGVPERGDEGTCRLCLQTPPQEPAPSTLAAEQDRVIEQVTETEELIKRSQDRLDELEAARSAQTRRRTELGEKLDRATATYVTDHTDRIRAIAAEQARLEEHLARIDDSLDLHNRLQGQIERVAELEREQEDLNNRIAASRHSNPEVHARLDQLDGAFENALRSFDAPRFDNQPGSRINRETYMPVVDGRSFVDLQSQGVEVLVNVAHVLAHQHVALHEEAVPLPNLLVIDGISSNVGHEGINLQRLRKMYATLLETATEHVDRLQIIVTDNDSPPIDGIHRALELSDTDRLVPTGESNDQCSEGEEAEPEADPSGPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NGT6</accession>
    <name>A0A0F7NGT6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_09960</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019915.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_09960"/>
    <dbReference type="EnsemblBacteria" id="AKH86649">
        <property type="protein sequence ID" value="AKH86649"/>
        <property type="gene ID" value="AA958_09960"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_09960"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2097"/>
    <dbReference type="OrthoDB" id="1181903at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042953">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
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        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015854">
        <property type="entry name" value="ABC_transpr_LolD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007159">
        <property type="entry name" value="SpoVT-AbrB_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24220:SF654">
        <property type="entry name" value="PTHR24220:SF654"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51740">
        <property type="entry name" value="SPOVT_ABRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="32"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="SpoVT-AbrB" evidence="6">
        <location>
            <begin position="274"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="65"/>
            <end position="72"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH86649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="320" mass="34766" checksum="5D378B742C95D3B0" modified="2015-07-22" version="1">MRSGTTLEDLERRAAEQRARPAYGHDALISCDQLVRIFRTDGVEVQALQGLDLLVAEGELLALVGASGSGKSTLLGILAGLDVPTAGTATVAGFDLLAMDARARLRYRREVVGFVWQQTARNLLPYLTAVQNVVLPMQLSEGGGGRHARRRRVAFAEDLLGLLGLAHCRDRRPQQMSGGEQQRAAIAVALANSPAVILADEPTGELDSATAEQIFAAFRTANEELGTTIVIVTHDQAVATQVRRTVAIRDGRMASEVVRRTEVDASGAERVVAREYAAVDRTGRLQLPQQYTEALDIRDRVVLDLEEDHIRVSPDREDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NGU2</accession>
    <name>A0A0F7NGU2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_10030</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019921.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_10030"/>
    <dbReference type="EnsemblBacteria" id="AKH86654">
        <property type="protein sequence ID" value="AKH86654"/>
        <property type="gene ID" value="AA958_10030"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_10030"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2112"/>
    <dbReference type="OrthoDB" id="1831905at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022791">
        <property type="entry name" value="L-PG_synthase/AglD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03706">
        <property type="entry name" value="LPG_synthase_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00374">
        <property type="entry name" value="TIGR00374"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="269"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH86654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="322" mass="33741" checksum="7A4CC0B7D6D6394C" modified="2015-07-22" version="1">MGRLWWVLAAGLITVGLLLAVSQRGELRRALELLTHVSPAKALVALVCQAGCLACLAGLQQWLLAVGGVRVSLAAMGRLVLAANAMAGALPGGAAFGTAWLYREFRRRGADRALTAGVLAASGVFSALALVVVIVLGVLLAGTRGPGMTLLWALAILALLALAGLIVLRSPAVRKALGRRWERIAARHEGLGSAGRATRDLIAHARTVRPGLRPWLTPAALALLNWLLDAACLLASLWALGLPVPWSGLLLAFALVQIPVSARITPGGLGIAEASLTGLLVVYGLHPGQAFAATLLYRIFSYWLLEPIGGACWLVTALERKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NH76</accession>
    <name>A0A0F7NH76_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PG_binding_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_31950</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019295.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_31950"/>
    <dbReference type="EnsemblBacteria" id="AKH86067">
        <property type="protein sequence ID" value="AKH86067"/>
        <property type="gene ID" value="AA958_31950"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_31950"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6747"/>
    <dbReference type="OrthoDB" id="1968187at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.101.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036366">
        <property type="entry name" value="PGBDSf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="SSF47090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="PG_binding_1" evidence="3">
        <location>
            <begin position="231"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH86067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="469" mass="46716" checksum="F3260BBECB794A35" modified="2015-07-22" version="1">MTSREETEELNLRERPPGALEVRPPGPLTAGGDPEGGGPGGEVAGAAPPAEGDGAAPPAEGDGAPSGPEPARRSRKLRMALIVVIAIGVAAAAGLAATGALGGEDSEEPAAGPSGPAATAEVKRTTLTSSETVDGTLGYGDVSTVEAIAPAAGGADPGADTGTGQPAGGGGTAAGSGGDAADAGAGIVTWTPNEGSTIKRGDTVYSVDGEKVPLFYGDTPLYRTLSDGSEGGDVELLERNLDKLGYTGFTVDETYSPDTADAVSAWQEDMGREQTGVVEAGDAVTAESARRVAALQTWPGAKAEGAVLDWTGTERVVSVELDAQFEDLVRVGTKAEVELPNGTTVDGKVTDIGTPPAASGSGSGDAGGQGEEDQESTLPLQLTVGEQDKLGRYQAAPVDVVLKADTREDVLAVPVNALVARQGGGYAVQKVTAGGSTESVPVELGMFANGLVEITGDGIEEGMSVGVPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NHU8</accession>
    <name>A0A0F7NHU8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_25220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_25220"/>
    <dbReference type="EnsemblBacteria" id="AKH87029">
        <property type="protein sequence ID" value="AKH87029"/>
        <property type="gene ID" value="AA958_25220"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_25220"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5315"/>
    <dbReference type="OrthoDB" id="1309950at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041674">
        <property type="entry name" value="TetR_C_22"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17928">
        <property type="entry name" value="TetR_C_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="19"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH87029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="194" mass="21160" checksum="ADA4F5B19A4BD3A9" modified="2015-07-22" version="1">MDGVSTPSLRRTPVQQRSAERLARILDACAELLDETGYEELTTSAVADRAGVPIGSVYRFFPNKRALADALAARNLDDFTGRVTRRLAAEPAQAGWRRILDSMLAEYVAMMRTVPGFAQVDFEANDPVAARLCDILAERLSLPVTPSLQRSCLVAVEAADALLQLAFRADPEGDAALLAETRTLLHAYLSRTLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NI19</accession>
    <name>A0A0F7NI19_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Anti-anti-sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_29055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_037780523.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_29055"/>
    <dbReference type="EnsemblBacteria" id="AKH87099">
        <property type="protein sequence ID" value="AKH87099"/>
        <property type="gene ID" value="AA958_29055"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_29055"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6122"/>
    <dbReference type="OrthoDB" id="1864829at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="1">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH87099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="119" mass="12620" checksum="AB13FFB8004DA192" modified="2015-07-22" version="1">MQIGDTLLVSLQGDLDDIAVVEVEEHLTREVARTGAGGMLIDVSGLSVVDTFIARVLARMVAMVRLLGAEVAVVGIQPAVAITLVELGVPMGDLDTALNAEKGLALLARLRRDGRRRAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NI21</accession>
    <name>A0A0F7NI21_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_33970</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019634.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_33970"/>
    <dbReference type="EnsemblBacteria" id="AKH86412">
        <property type="protein sequence ID" value="AKH86412"/>
        <property type="gene ID" value="AA958_33970"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_33970"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.7173"/>
    <dbReference type="OrthoDB" id="1074175at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="73"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="69"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH86412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="278" mass="30061" checksum="35D31B3660976482" modified="2015-07-22" version="1">MARTLLRLLRYGALGLGAVAALLPFYYMLIGALQKKRDTSLGGLLPDPSNLTLANLSGIDDSFSLTTALLNSLIMTAGVVACTLVFGLLAGYALAILHFRGRGLVFALVLLVQAIPFQLLMIPLYVMVVRYFHLADSYAGMILPFAVNSVAVLIFRQYFLQIPREIFDAARMDGAGELRILRSVAVPLVRPAILTAMLVTFIGPWNEFLWPFLITKNPDMQPLAVSLANFSQANSTFQANPMGAVLAGACVLAVPAVVLFLLFQRHFTSANLGSAIKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NI41</accession>
    <name>A0A0F7NI41_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP/GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_29620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_29620"/>
    <dbReference type="EnsemblBacteria" id="AKH87119">
        <property type="protein sequence ID" value="AKH87119"/>
        <property type="gene ID" value="AA958_29620"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_29620"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6252"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NB-ARC" evidence="1">
        <location>
            <begin position="494"/>
            <end position="679"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH87119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="1283" mass="142457" checksum="6542E89FC1149AE0" modified="2015-07-22" version="1">MALANVAWILAANGKRVLAVDWDLEAPGLHRFFHPFLDSNTLASTTGVIDIITEYSWAATTGPPRVGEWHREYARTEDHAVSLNPGRLRWSFPENGCLDFLSAGRQSREYSATVTSFEWDNFYERLGGGLFLDALRDDMKSLYDYVLIDSRTGLSDNADICTIHMPDVLVDCFTLSDQSLDGAALVAHSVAGGYRGREIRVLPVPMRIDEGEKDKMDAGRALARLRFDGLPAGLGGEELTAYWGAVEIPYRPYYAYEETLATVSDEPGLASSLLSAFERLTDVITEGDVDALPTMPEPVRLRCKDAFTRRRPSATRTDVVLVYVAENRMWADWVESLLTRSGCQVTPVDLSVRAMEQPDGPARTVVLLSKSFFKARGREATWRALAETDLGSPQGGLVALRLDDVYAPGAYPDRNLVSLRVDEEADTASVLGALDLPALPADTGPSACRYPGSTPRIWNAPQRNAAFTGRNVVLERMRDQLSSGMSVVLPRSQALFGLGGVGKTQVAIEYVHRFMAEYDLVWWISAENTDNVIASLAELAARLGTHSGENMAMASREAVRMLSRGEPTSRWILVFDNAAEPEALTDYFPSEGSGHIVITSRNQAWAQHGDSLPIDVFLREESVDHLMSHDARLTAEEADRVATAVGDLPLAVVQAAAWLAETATPIEDYLQQLADQTTAALSLNQPADYPHPVAATWNISIARLKERSPASVRLLELCAFLAPEPISAQLLYSREMIDALKPYDPALQEKLVLGRVIREIGRFALAKIDQVSNSLQVHRLVQAVVRSQLTEEEQREARHLVHTVLAGARPDGEEPIDDPETWPQFGIIWPHLLPSDTPHCVTHETRRLLIDRVRYLWKRGDFPRAQQLAEEVLDHWRPTLGETDVQYLYLRNQLANVLRSQGRYVEARDIDTELLEQQRQALGPDHPHTYVTMSSLASDLAALSSYGRAAELAREAHEGFSRIFHSSHRRTLSAANNLALALRLDGRYRDALKLDQDVLDMRKEVLGPDHPYTLASAERLGRDLREVGRYAEAVSLLQRTYEAHTRVLGKDFPGTLRCAKSLAVSLRRSGQFENARRLTAATRAQYRAQYEEATPDSLACDLNMAADLFAADERQAAREVAREAIAEYTKVPGEAHPYTLAALNNLAIFHWGCGDDDEAETVFRAVLPRMTEVLGDAHPHTMFCAINYANVLAGQRRWEDARKLEARAVEVLGTSLGRHHPETLAIVTNAALTLKALGHTDEAQVMRDEAMAELRRQLGEDNGITKVAGDSRRIYRDLEPLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NI48</accession>
    <name>A0A0F7NI48_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Copper oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_21480</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020294.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_21480"/>
    <dbReference type="EnsemblBacteria" id="AKH86943">
        <property type="protein sequence ID" value="AKH86943"/>
        <property type="gene ID" value="AA958_21480"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_21480"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4522"/>
    <dbReference type="OrthoDB" id="971126at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="PTHR11709"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Plastocyanin-like" evidence="5">
        <location>
            <begin position="87"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="3">
        <location>
            <begin position="239"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="4">
        <location>
            <begin position="370"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH86943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="502" mass="54995" checksum="C91A0FEB2A2D9ACD" modified="2015-07-22" version="1">MAVAIVTVAVGAGAWFYATADVSTVGKVDFADELRIPPLEEGEVEADGTRVFRLGMRAGETEFGPGRTTPTWGFTSPATAADTRWPGTYLGPTLRAERGEKVRVEVDNGLDEPSTVHWHGMHLPAAMDGGPHQTVEAGGEWRPHWTVDQPAATLWYHPHPHGRTERHVQRGLAGMFLVDDAKARKLGLPDEYGVNDVPVVVQDVRFDGDRFDHGHRMMRNTGFLGDETMVNGTLAPYQEVRDAVVRLRLLNASTARVYDFGFADDRAFELVGTDGGLLGAPYRTDRVLLSPGERAEILVRMRPGERTVLRSSPPGGGDFWQSRFAGGDDSFDVLELRAAGTLRPAPAVPARFGDVELPDPADASRERHFDLRTSGINGQPMAMDRIDATVERGATEIWTVRNRDGITHNFHVHDVQFRVLEVDGEPPPPELRGRKDTVYVPNGREVKLVLRFDGPPDPDVPYMYHCHLLSHEDGGMMGQFAVVNPGEKAGRPPGGGEGHGGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NIJ9</accession>
    <name>A0A0F7NIJ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_28740</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the DedA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020488.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_28740"/>
    <dbReference type="EnsemblBacteria" id="AKH87093">
        <property type="protein sequence ID" value="AKH87093"/>
        <property type="gene ID" value="AA958_28740"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_28740"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6057"/>
    <dbReference type="OrthoDB" id="1928533at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032818">
        <property type="entry name" value="DedA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="SNARE_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30353">
        <property type="entry name" value="PTHR30353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="SNARE_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="27"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH87093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="214" mass="22722" checksum="DFA6491D6F3165BC" modified="2015-07-22" version="1">MPNAPPELLAAARDVAPAQQAVGYPSLFLLVLVGSLVPVVPTGAVVSSAAVVAFHHEAAYALLLVFGTAAIAAFLGDVALYWLGGRGVRSRNGSRWLDRLRDRVAPEQLAHAQRRLEQHRISVLVLSRLLPAGRIPVMLACLLARMPLRTFVRGNFPACLAWAATYQLIGILGGSLFPEPWQGVAAAVALTVLISVAPPVWRRLRGHGGPGRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NIN1</accession>
    <name>A0A0F7NIN1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Probable nicotinate-nucleotide adenylyltransferase</fullName>
            <ecNumber evidence="6">2.7.7.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Deamido-NAD(+) diphosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Deamido-NAD(+) pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Nicotinate mononucleotide adenylyltransferase</fullName>
            <shortName evidence="6">NaMN adenylyltransferase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">nadD</name>
        <name evidence="8" type="ORF">AA958_09480</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 6">Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>ATP + H(+) + nicotinate beta-D-ribonucleotide = deamido-NAD(+) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22860"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="EC" id="2.7.7.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 6">Cofactor biosynthesis; NAD(+) biosynthesis; deamido-NAD(+) from nicotinate D-ribonucleotide: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the NadD family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.18" evidence="6"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_09480"/>
    <dbReference type="EnsemblBacteria" id="AKH86642">
        <property type="protein sequence ID" value="AKH86642"/>
        <property type="gene ID" value="AA958_09480"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_09480"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1999"/>
    <dbReference type="OrthoDB" id="1433958at2"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00332"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004515">
        <property type="term" value="F:nicotinate-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02165">
        <property type="entry name" value="NMNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00244">
        <property type="entry name" value="NaMN_adenylyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005248">
        <property type="entry name" value="NadD/NMNAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00482">
        <property type="entry name" value="TIGR00482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4 6" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CTP_transf_like" evidence="7">
        <location>
            <begin position="10"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH86642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="199" mass="22326" checksum="89779FD427B6CE0F" modified="2015-07-22" version="1">MRAVRRRLGVMGGTFDPIHHGHLVAASEVAARFHLDEVIFVPTGEPWQKSDKAVSPREDRYLMTVIATASNPQFSVSRIDIDREGPTFTIDTLRELHGLEPDAELFFITGADALSQIFTWRGAEELFSLAHFIGVTRPGHRLHDPGLPEGRVSLVEVPALAISSTDCRERVARDEPVWYLVPDGVVRYINKRRLYRDGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NJU9</accession>
    <name>A0A0F7NJU9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cellulase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_27115</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020444.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_27115"/>
    <dbReference type="EnsemblBacteria" id="AKH87057">
        <property type="protein sequence ID" value="AKH87057"/>
        <property type="gene ID" value="AA958_27115"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_27115"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5714"/>
    <dbReference type="OrthoDB" id="1395441at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071704">
        <property type="term" value="P:organic substance metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002520177" evidence="3">
        <location>
            <begin position="26"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="Cellulase" evidence="4">
        <location>
            <begin position="60"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH87057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="398" mass="43802" checksum="E7E4EBDA28364E0D" modified="2015-07-22" version="1">MKIKAVLVAIILAVAASVYGVSAHAASAGTTARSDASRIVADMGAGWNLGNQLEANIDGYPGETSWGNPKVSQALIDKVHGAGFKTIRIPVSYLRNIGPGPDYAIDSSWLNRVQEVVDYAYRRGMYVVINMHGDGYKTINGSWLICDAASQTEIKDKYRKVWQQIASRFQGYDQHLILESMNEEFDGQYGQPTQPCYSNINDYNQIFVDTVRRTGGNNTSRWLLVPGWNTNIDYTAGDYGFAIPTDEYRSPSIPGDEQRIMISVHYYDPWDFAGEENGNITQWGPAATDPSKTSTWGQEDHLDAQLKKMHDGFVTKGYPVVVGEYGAIDKSSFDSANNSYRADFAHTLAATAKKYGAVSVYWDNGVNGRYGFGLFDRNSYTVTQQGILSAIMSGVDGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MXH1</accession>
    <name>A0A0F7MXH1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methoxymalonyl-ACP biosynthesis protein FkbH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_00705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH80930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AKH80930">
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        <property type="gene ID" value="AA958_00705"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_00705"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.161"/>
    <dbReference type="OrthoDB" id="1310135at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HAD_SF_ppase_IIIC"/>
    </dbReference>
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        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
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        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01681">
        <property type="entry name" value="HAD-SF-IIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="463"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH80930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="633" mass="68995" checksum="93FA2682F6829CB4" modified="2015-07-22" version="1">MSAAPAPPPSAPDPVAELHRSGSLVAEYPRLPALLHGLGEDERQRAGRLLSRLSPDEVLAVHPGVPTVSVAVTGHGTVAGLVPPLTMELARHGMLLRSHVADYDSWLFDLADPAGEVYAAGTDLVVCLLAAGIVFDEVPRPWRPEDVERVLTEKVHLLGKLAATHGTSGSGTLVYTTMPLPREFTAQLVDHRSRARLGAVWREGNARLLGLMDEHPGLVVLDLDPLLTGPAALAEDRLATYVGTPFAAELTAAVAREVAHLARGRSGRAKKVLAVDLDNTLWGGVLGDDGREGIEVADGRTGRAFQRMQRVVKQLASRGVLVAAVSKNDVEPVREVLRDHPEMTLREDDFVRVVANWSPKHDNLRALAEDLNLGLDSFVFADDSPYECGLVARELPEVTVLHLDGDPALHAGRLLADGWFDVRDLTDDDVRRPERYREELVRKDFLDSFSSLDDYLRELDVRVELTAAAEADVPRVAQLTQRTNQFNLTTRRLQQDEVASLAGSPGNLVLAIRSGDRFGDNGLVGAVFVRTDGPVWHVDNFLLSCRVFARGIEQGCLSALLEHARAEGAEAVAAQYVPSPKNGKVRDFYSRNGFDAHGHAEDGTADFRHELRQIDAVPAHLALTVRWAREGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MYX9</accession>
    <name>A0A0F7MYX9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FAD-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_03905</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81475.1"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_03905"/>
    <dbReference type="EnsemblBacteria" id="AKH81475">
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        <property type="gene ID" value="AA958_03905"/>
    </dbReference>
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    <dbReference type="PATRIC" id="fig|444103.5.peg.820"/>
    <dbReference type="OrthoDB" id="1630289at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
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        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
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        <property type="entry name" value="SIP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039374">
        <property type="entry name" value="SIP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30157">
        <property type="entry name" value="PTHR30157"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08021">
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FAD_FR"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="2">
        <location>
            <begin position="10"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH81475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="286" mass="31336" checksum="51AFA98B037AA82C" modified="2015-07-22" version="1">MADRPAGRKRQVHTARVVRTEQLTPHMVRVVLGGDELAGFTAGEWTDHYVKLLFPAPGAEYPEPYDLDAIRRDLPRDRWPLMRTYTVRDWDAKARELTLDFVVHGAAGVAGPWALRAGPGEVVRFLGPGGAYAPSPAADWHLLAGDESALPAIAASLERVPDGAVTHVLIEVADAAERQPLAAPEGAVTWLCRDGRPVGRALVEAVRALEFPPGRAQVFVHGEAGMVKELRRHLRLERGVPREQLSISGYWRLGHDEDGWQSSKKQWNEAVEREQEGAEPAAGSAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MZ33</accession>
    <name>A0A0F7MZ33_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polysaccharide deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_01035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH80986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014352.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_01035"/>
    <dbReference type="EnsemblBacteria" id="AKH80986">
        <property type="protein sequence ID" value="AKH80986"/>
        <property type="gene ID" value="AA958_01035"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_01035"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.228"/>
    <dbReference type="OrthoDB" id="1701876at2"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
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        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="1">
        <location>
            <begin position="33"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH80986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="287" mass="31567" checksum="3F2D41FECE686D9C" modified="2015-07-22" version="1">MTTTGSPRPGGDTVAALTIDVDAHSPVLARSRRYAAHTGTMSHQQYGVDVGVPRLLRLLDEEAVPATFFVPGWVAEHHPGLTAAILEQGHEVAHHTYAHRPPVEMTDDEQRADFTRALEVFAAQDVPVEGFRAANWQSNETTCRLVAEHGLYDSSLMGHDRPYRVTTTDGGRFVELPPHWSLDDWEQYAFLPDPHVGSVIQAPHTVLAMWRDELDAHARHQALFMLTLHPELTGRPARAEALRSLLAYARGRGIRFAHCADIARAAAADPHLTTHSTAPPTADAYPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MZ88</accession>
    <name>A0A0F7MZ88_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Histidinol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_01405</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014406.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_01405"/>
    <dbReference type="EnsemblBacteria" id="AKH81041">
        <property type="protein sequence ID" value="AKH81041"/>
        <property type="gene ID" value="AA958_01405"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_01405"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.310"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH81041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="230" mass="25029" checksum="19585D225CC5972B" modified="2015-07-22" version="1">MLEVQGVTAHYDEAEVLREVSLTVGAGEVVTLVGRNGAGKTTLLRCVMGLHRRTTGTIRLAGRDLGAVPPHRRARRGLGYVPDDRGIYAGLSVEENLTLPPAKADSAWPLARVYEEFPALAERRRSAGGKLSGGEQQMLALARVLRTGAGVLLCDEPTEGLAPIVVERIGEILREAKRHGTAVLLVEQNLRFATTVADRHYLLDRGRIAESLANDDVREREHELLGYLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MZH0</accession>
    <name>A0A0F7MZH0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_05180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015045.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH81690">
        <property type="protein sequence ID" value="AKH81690"/>
        <property type="gene ID" value="AA958_05180"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_05180"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1088"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH81690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="107" mass="11401" checksum="E285F929B5CA950C" modified="2015-07-22" version="1">MPLNGTDGDHRVRIPQPAARHALRHGGGPWAAAVRPARHLLLRLAEPARRAEARRLLALVLDVPPLPGAEPAVLIAEVPDGRRAVDVLIELAWAGIELDGFALDAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0D0</accession>
    <name>A0A0F7N0D0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Multidrug transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_03620</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014784.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_03620"/>
    <dbReference type="EnsemblBacteria" id="AKH81426">
        <property type="protein sequence ID" value="AKH81426"/>
        <property type="gene ID" value="AA958_03620"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_03620"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.762"/>
    <dbReference type="OrthoDB" id="1921902at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000390">
        <property type="entry name" value="Small_drug/metabolite_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045324">
        <property type="entry name" value="Small_multidrug_res"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30561">
        <property type="entry name" value="PTHR30561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00893">
        <property type="entry name" value="Multi_Drug_Res"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH81426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="107" mass="10640" checksum="8F3201B34BC2B06A" modified="2015-07-22" version="1">MTYVLLIGAILSEVTATVSLRLSEGFSKILPSLVVVVGYITAFTLLSLVLKRGMSIGIAYGIWAAAGVALVALIGAAFLGDGLTGVQIGGLVLVAAGVVALEAGGAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-10-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0D2</accession>
    <name>A0A0F7N0D2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_00085</name>
        <name evidence="2" type="ORF">AA958_34175</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH80834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH80834">
        <property type="protein sequence ID" value="AKH80834"/>
        <property type="gene ID" value="AA958_00085"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86437">
        <property type="protein sequence ID" value="AKH86437"/>
        <property type="gene ID" value="AA958_34175"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_00085"/>
    <dbReference type="KEGG" id="strc:AA958_34175"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.18"/>
    <dbReference type="OrthoDB" id="2024044at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH80834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="232" mass="25778" checksum="D7B74510A96A5787" modified="2015-07-22" version="1">MGLVRVRSFVRRESIEAHNTRVLADLGPGLPMATIDALYTELLRRTREAMQGRPVARWTELLAVDDPPAAVLNKRVSAEVIADVRQRLTRPDHVLLQDLSQQLTGSETSLVRKLRQGAASKGVIQDAQMMRANADHHRLREAALGTWPDDPAVEADLDQRLLFLARRVGRTHEENSRPANAIFAALQVELQNNPGAYDRAPLYAQDGVLLMGRACAVSDECRFDWGDARDAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0N7</accession>
    <name>A0A0F7N0N7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oleoyl-ACP hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_00615</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioesterase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH80914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_00615"/>
    <dbReference type="EnsemblBacteria" id="AKH80914">
        <property type="protein sequence ID" value="AKH80914"/>
        <property type="gene ID" value="AA958_00615"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_00615"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.143"/>
    <dbReference type="OrthoDB" id="1119700at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012223">
        <property type="entry name" value="TEII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11487">
        <property type="entry name" value="PTHR11487"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="2">
        <location>
            <begin position="24"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH80914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="260" mass="28740" checksum="4D258DBDE4CA5C2A" modified="2015-07-22" version="1">MPTEIPFDETWLRRFGTARQPDVRLVCLPHAGGAATTFFPLQRELPPSVEFVAVQYPGRHDRRHEQPLRDVRTLADRVAAALRPLTDLPLVLFGHSMGAVVGFETAARLERDGANPPLGLVASGRHSPATPRVETVHQRDDDGLIDEITKLSGTDPQILADPDMRAMILPALRADYTAVETYRYDRSFLLRCPVSVFTGTADPKVTEHEAAAWEPLTSGAFRIERFPGGHFYLDGAERAVATALLRDIRAFTNAPATQPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0T1</accession>
    <name>A0A0F7N0T1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">XRE family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_00915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH80964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014330.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_00915"/>
    <dbReference type="EnsemblBacteria" id="AKH80964">
        <property type="protein sequence ID" value="AKH80964"/>
        <property type="gene ID" value="AA958_00915"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_00915"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.203"/>
    <dbReference type="OrthoDB" id="1746185at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="16"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH80964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="290" mass="31708" checksum="E284CF5DF3B851ED" modified="2015-07-22" version="1">MRDEPAVRRAKLGAELRRLRGSAGLTSGKAAELVGWHQSKISRIETGRSAAKAADVARLLDAYGVTEPELRTLLETPATAPHECREDRWWSEYRELLPAAYRDFISLEAEATTVRTLETSVVPGLLQTRRYALAVTRAAVANAAPREVESLVEVRIARQAVLRATHPPHLHAVLDEAVLRRHVGGPGVMAEQLHHLGRMGALPYVHVQILPFSAGEHVGLTGPFVIFSYSRSSDLDVVVVDHLMSSLHLERKEDLRAYETTFASLQASALSHEESLSFIAALGAGAKEAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0U3</accession>
    <name>A0A0F7N0U3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LuxR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_04740</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014971.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH81616">
        <property type="protein sequence ID" value="AKH81616"/>
        <property type="gene ID" value="AA958_04740"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_04740"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.999"/>
    <dbReference type="OrthoDB" id="1687028at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="5"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="151"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH81616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="223" mass="24017" checksum="5CB63218E7F397F7" modified="2015-07-22" version="1">MTNIRVLIADDQVMVRQGFTVLLDAEPGIEVVGQAVDGADAVAKTAELRPDVVLMDIRMPGLGGIEATRRLTEPPSAAVRVLILTTFDLDEYVYEALRAGASGFLLKDASAAELAHAVRVVATGDALLAPAVTRRLITEFARLTRTPRTPLKDRVGGLTERETEVLSLIAQGLSNAEIAERLVVAEQTVKTHVGRILTKLSLRDRTQAAVFAYETGLIRPTGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0W8</accession>
    <name>A0A0F7N0W8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Bacteriocin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_08485</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Encapsulin nanocompartment</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the encapsulin family. Family 1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015613.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_08485"/>
    <dbReference type="EnsemblBacteria" id="AKH82265">
        <property type="protein sequence ID" value="AKH82265"/>
        <property type="gene ID" value="AA958_08485"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_08485"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1791"/>
    <dbReference type="OrthoDB" id="1252793at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007544">
        <property type="entry name" value="Linocin_M18"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04454">
        <property type="entry name" value="Linocin_M18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019254">
        <property type="entry name" value="CFP29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1284">Encapsulin nanocompartment</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00033738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00033743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00033787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH82265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="265" mass="28565" checksum="75752FCB12FA0D85" modified="2015-07-22" version="1">MNNLHRELAPITQAAWAEIEEEARRTFRRHVAGRRVVDVTGPEGPELAAVGTGHLEEIAPPAPGATARLRAAQSLIELRVPFTVSRDAVDDVERGSRDSDWQPVKDAARTAAFAEDRMIADGYAAAGVEGLRTRSSLPELSLPAEVRDYPDTVSRALSALRLAGVDGPYSLLLGADAYTAVSETADHGYPVAQHISRLLDGELIWAPAMTGGLALSTRGGDFELRLGEDLAIGYTAHDAKTVQLYLHETLTFLTYTDEAIVVLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N152</accession>
    <name>A0A0F7N152_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_05465</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015090.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_05465"/>
    <dbReference type="EnsemblBacteria" id="AKH81736">
        <property type="protein sequence ID" value="AKH81736"/>
        <property type="gene ID" value="AA958_05465"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_05465"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1146"/>
    <dbReference type="OrthoDB" id="1465613at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029475">
        <property type="entry name" value="PmoA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14100">
        <property type="entry name" value="PmoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH81736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="288" mass="30570" checksum="14506180BDE980FD" modified="2015-07-22" version="1">MTVPSRNRTGTDAATLLSCAGRRVGRYVHRPRLDARLSPRPYLHPLTTLAGVPVTELMPGDHPHHLGVSIAVPDVSGANFWGGRTFVRGRGPVEPADHGEQRHAGWLLRDPDGFVEELGWYAGGAEVLRERRAVAVAPAGDGAWALGVSFALTNVSGAPVSFGSPATNGRPGAGYGGYFWRAPRTERPPRVFTAAAEGEEAVHGRPARWLALASDAWTLVFAGATDATRRDPWFVRARDYPGVGSALAWSARVPLAPGASLTRRVVTAVADGRLDRTAAAALARRAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N174</accession>
    <name>A0A0F7N174_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C4-dicarboxylate ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_01905</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0065 (bug) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014493.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_01905"/>
    <dbReference type="EnsemblBacteria" id="AKH81129">
        <property type="protein sequence ID" value="AKH81129"/>
        <property type="gene ID" value="AA958_01905"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_01905"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.412"/>
    <dbReference type="OrthoDB" id="988124at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005064">
        <property type="entry name" value="BUG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042100">
        <property type="entry name" value="Bug_dom1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42928">
        <property type="entry name" value="PTHR42928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03401">
        <property type="entry name" value="TctC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017082">
        <property type="entry name" value="YflP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519673" evidence="2">
        <location>
            <begin position="34"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH81129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="331" mass="34469" checksum="7252CE84A39109DE" modified="2015-07-22" version="1">MRLPTTLRTPFALAAAALLVLLGPPLITEGDGAASGSRIPGLELMVPNTPGGGYDITARTIARNIEEAGLGSNVEVFNLPGAGGTVGLSRLVNEHGNGKLAMSMGLGVSGAVRTNSTGHTLADTTPIARVTEEPDIVVVPADSPYTTFEDLLADWKASPGKTPVGGGSSPGGPDHLAPMLMARAAGIVPKEVNYVPYDGGGELLASILGGKVAFGVSGVGEYLDQIDAGDLRVLAVTSGERHPGLDAPTLRETGIDVAFTNWRGFVAPPGLSGTERKNLIHLFEKLHDTGEWRQSLKTNGWTDAFLTGEKFGDYLDAQDRRVVSVLKELGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N1P5</accession>
    <name>A0A0F7N1P5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Bifunctional protein PyrR</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="4">Pyrimidine operon regulatory protein</fullName>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="4">Uracil phosphoribosyltransferase</fullName>
                <shortName evidence="4">UPRTase</shortName>
                <ecNumber evidence="4">2.4.2.9</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="4" type="primary">pyrR</name>
        <name evidence="6" type="ORF">AA958_03135</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.</text>
    </comment>
    <comment type="function">
        <text evidence="4">Regulates the transcription of the pyrimidine nucleotide (pyr) operon in response to exogenous pyrimidines.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>diphosphate + UMP = 5-phospho-alpha-D-ribose 1-diphosphate + uracil</text>
            <dbReference type="Rhea" id="RHEA:13017"/>
            <dbReference type="ChEBI" id="CHEBI:17568"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.9" evidence="4"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014698.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_03135"/>
    <dbReference type="EnsemblBacteria" id="AKH81338">
        <property type="protein sequence ID" value="AKH81338"/>
        <property type="gene ID" value="AA958_03135"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_03135"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.668"/>
    <dbReference type="OrthoDB" id="1725260at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004845">
        <property type="term" value="F:uracil phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01219">
        <property type="entry name" value="PyrR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023050">
        <property type="entry name" value="PyrR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="5">
        <location>
            <begin position="13"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="PRPP-binding" evidence="4">
        <location>
            <begin position="107"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH81338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="186" mass="20356" checksum="4E97FE2E240DBAB2" modified="2015-07-22" version="1">MDTHSPEPARPVLEAPDIQRVLTRIAHEIVERTKGAHDVVLLGIPTRGVWLGHRLAAKLEEITGSKFGQSGVGSLDITMYRDDLRMGPPRALARTDIPAEGIDGRLVVLVDDVLFSGRTIRAALDALNDIGRPRAVQLAVLVDRGHRELPIRADYVGKNLPTSLRETVRVQLTEEDGRDAVLLGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N1P6</accession>
    <name>A0A0F7N1P6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Mechanosensitive ion channel protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_02950</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MscS (TC 1.A.23) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014667.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_02950"/>
    <dbReference type="EnsemblBacteria" id="AKH81304">
        <property type="protein sequence ID" value="AKH81304"/>
        <property type="gene ID" value="AA958_02950"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_02950"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.630"/>
    <dbReference type="OrthoDB" id="1597438at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011066">
        <property type="entry name" value="MscS_channel_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011014">
        <property type="entry name" value="MscS_channel_TM-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82689">
        <property type="entry name" value="SSF82689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82861">
        <property type="entry name" value="SSF82861"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH81304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="362" mass="38479" checksum="A986DC598E623ED9" modified="2015-07-22" version="1">MNRALTLHDLVVAGSAILGGIGAGLLLRVLLGWLGKGATRTSWAGDDILVGALRTMAPWGALAGGVSIAAAALPLKRPVEHTVEQIVVAVLILTVTVAAARVVAQLMGVRSQGVGSATILVNITRIAVLAIGLLILLETLGISIAPLLTALGVGGLAVALALQDTLANLFAGVHILASKTVQVGDYIRLSSGEEGYVTDINWRNTVIRTQSDNLVVIPNDQLASTIMTNYHRPEQELSIVVQAGVALSSDLDLVERVTVEVAHEVMAAVEGGVPDHDPVVRFHTFGDSRAGFSVVLRALEFSDQFRIKHEFIKRLQLRYREEGIEIAHPVRNIVLQHQDTPVLLLPRQRKESDVPVGGPSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N1R2</accession>
    <name>A0A0F7N1R2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_03225</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_03225"/>
    <dbReference type="EnsemblBacteria" id="AKH81353">
        <property type="protein sequence ID" value="AKH81353"/>
        <property type="gene ID" value="AA958_03225"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_03225"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.687"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009293">
        <property type="entry name" value="UPF0478"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06103">
        <property type="entry name" value="DUF948"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH81353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="146" mass="14913" checksum="FAB6686ED6F11D1D" modified="2015-07-22" version="1">MAGILVAVFWAILVSFLAVALFRLARTLRAAGELVTRVTEEAVPLLTEAGATVRSANTQLARVDAIASDVQEVTANASALSSTVSTAFGGPLVKVAAFGYGVRRALGRNRGPAGDDGDVIVGRPVGGPAGARVPAARGFSARRRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2G3</accession>
    <name>A0A0F7N2G3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_11910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH82820">
        <property type="protein sequence ID" value="AKH82820"/>
        <property type="gene ID" value="AA958_11910"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_11910"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH82820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="88" mass="9340" checksum="311BE9454AC8399C" modified="2015-07-22" version="1">MTGAVRRCGATVTASAGSGELRPGVMLVRLTRKLDILRLTTRGLERLRRVGSRRTVISRSPSGSAAARCSGGMVHIRAGYRPGALDHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2G5</accession>
    <name>A0A0F7N2G5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_08045</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015541.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH82191">
        <property type="protein sequence ID" value="AKH82191"/>
        <property type="gene ID" value="AA958_08045"/>
    </dbReference>
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        </location>
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    </evidence>
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            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH82191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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        </source>
    </evidence>
    <sequence length="332" mass="35918" checksum="27E7879BD9B7D924" modified="2015-07-22" version="1">MSTQSTDKAPDMTSGGGSETGHITEDLTFRIRTSADPENEWELSAQLVIPEGGADTVQVLLPGLTYDRRYWQVPGEYDYCDHMLRAGYAVLLLDRVGTGASSRPPATQLHADSHVETIHHVIQQLRSGTPSGHSFGKIVSVGHSYGAGIAIMEAAAHADIDALVVTGMLHTTSPLYDEVINFFHPGSQDPVLNDASLPQWYMTQRPGLRARMLEHADGMDPELSAHNEKIKSTATIGEGESLPKTYLPEHSRAVKVPVLLVVGEHDALFSSADVDFAATGEAVLAFEADFYAAESELEAHVIPGAGHSLNVHRNATDSYAIVRDWVDRKLSG</sequence>
</entry>
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                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="472" mass="50564" checksum="0A5D3A984AF2EA18" modified="2015-07-22" version="1">MFEPAIAPSGTLLGLLQRGRGDGTLHALAAPRAEALQALYECVIDDPRHDWQVENRSLYYARLCLELDAPVDALADHLFAPDDVLRPDEQRTGLTLSVLGHLASYGRDDALKLLRRYAAAGGCWQWALDELALRDDDAGLRALAPHVLARFPRTPEGERELAAEMRGAFEPRPWRLWAEDPELGARVRAAQEQESFDRWQRQLRSRGPRPGWSVAEILQWAQDGLEQYPAQPRHAAAARCLAAVAGPEDRPELFAAARAGGDGARAAAVAHLAATGDPETYDLIEAAVCGPSEILADAALATFGRMCSTAALGAARSWAGREDALGTAAGVMLARRGAARDARAVRAVLLRRVRDGGPDAPELCDLVAGAGRLAIASAAPVLRHIYRETGSSQLRGVTARALAATDPSFPASFAVECLWDCEDTTREIGARHAETADARVVARLRSLAADPAEDGDVQSTVRTRITPDGAAG</sequence>
</entry>
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    <accession>A0A0F7N2T6</accession>
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    <organism evidence="1 2">
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                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">CNQ-509</strain>
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    </dbReference>
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    <dbReference type="OrthoDB" id="1414748at2"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH81157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="165" mass="18395" checksum="1BA3BA54E9D5917A" modified="2015-07-22" version="1">MAVYICSLIVDEPQVIPADGEYHIVRFPYGARESFDAHGMHQAAQPDGKRSSYPDRRSGLIWPSREGWGSLTAMVYWEKGDYTEVRDRFVRDPLGLAGGYDATATEDHAGTPGGEYRHKHHEIFVRPRTPLAFLVRHNGARSARIIHAQFKLAIHPAAEMPAAGS</sequence>
</entry>
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    <accession>A0A0F7N2U9</accession>
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        <name evidence="2" type="ORF">AA958_05255</name>
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    <organism evidence="2 3">
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        <lineage>
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        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="PATRIC" id="fig|444103.5.peg.1103"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="8"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="135" mass="14457" checksum="E7D9786FD8F18F58" modified="2015-07-22" version="1">MPGSHDAPTVYPTLLYDDAKAAVRLLTEGLGFREVAVFEGEDGRVVHAELAQGNGMVMLGSKGTGSEFDRAVGAGGPSGVYVVVDDPDAHHRQAVEHGVEILMPPTDQDYGARDYMARDHEGNVWSFGTYAPTPR</sequence>
</entry>
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    <accession>A0A0F7N2V0</accession>
    <name>A0A0F7N2V0_9ACTN</name>
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    </protein>
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        <name evidence="5" type="ORF">AA958_02175</name>
    </gene>
    <organism evidence="5 6">
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        <lineage>
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        </lineage>
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    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="2"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH81172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="337" mass="35624" checksum="42086AC3BD35364A" modified="2015-07-22" version="1">MVGIKDVARHAGVSVGTVSNVINRPDSVAAATRERVQAAIDRLGYVRSESARQLRAGRSRIIALLVLDMTNPFFVDVATGAERAAREAGLGVMLCNSAQSPAEEAEYLGLFAEQRVRGVLVTPADTSGRTLESFGRHGIPYVFVDRTVASADACSVSLDDVQGGVLAARHLIGAGHGSLVYVSGPMQLPQCQDRHTGALAALAEEGLGPEALIHVETEQMDVAAGRDAGARLLGMSPRPSAVFCANDLLALGVLQTLFAAGVSVPGDIALVGYDDIEFAAAAAVPLTSVRQPAHRMGREAAELLIEETERGVEDHDHQRIVLQPELVVRSSSLRQQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N319</accession>
    <name>A0A0F7N319_9ACTN</name>
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        <submittedName>
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        <name evidence="3" type="ORF">AA958_05740</name>
    </gene>
    <organism evidence="3 4">
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        <lineage>
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            <taxon>Actinobacteria</taxon>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015137.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_05740"/>
    <dbReference type="EnsemblBacteria" id="AKH81784">
        <property type="protein sequence ID" value="AKH81784"/>
        <property type="gene ID" value="AA958_05740"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_05740"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1201"/>
    <dbReference type="OrthoDB" id="1548598at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017517">
        <property type="entry name" value="CHP03083_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024344">
        <property type="entry name" value="MDMPI_metal-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036527">
        <property type="entry name" value="SCP2_sterol-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11716">
        <property type="entry name" value="MDMPI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55718">
        <property type="entry name" value="SSF55718"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03083">
        <property type="entry name" value="TIGR03083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MDMPI_N" evidence="2">
        <location>
            <begin position="4"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH81784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="226" mass="23968" checksum="23C0E1FE2D6B2964" modified="2015-07-22" version="1">MATLRAATDRLLDNAARLGDDAVRAPSALPGWTRGHVLSHLARNADALVNVLSGRPMYASAEARDADIEAGAPRPLAEQLDDVRATADRLAGTAADIPADGWSARCELRNGVTDVMARIPFRRLVEVELHHVDLDAGYTLDRLPEEFVTREIDFLTARFAGDERVTPLSLSAPDGSTWTTGAPPSGGDPVRVTGAPYALMGWLAGRTTGTGVRTENGAALPTLPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N342</accession>
    <name>A0A0F7N342_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Guanyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_13430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_13430"/>
    <dbReference type="EnsemblBacteria" id="AKH83065">
        <property type="protein sequence ID" value="AKH83065"/>
        <property type="gene ID" value="AA958_13430"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_13430"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2824"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="207" mass="22713" checksum="AC9C4E2F6B9445BA" modified="2015-07-22" version="1">MVEIPGTGVPIIGHQLAWLAAEGVTDAVVSCGHLAEVLMDWLDASELPLKVTCVVEKEPLGRGGGLKFAAESLPRPDEPWYATNGDIWTRFSLAAMAAFHQERGADATLALARPHMPWGAVETDQFGHVIDFIEAPPSPYLINAGVYVFSAAFRDLLPERGDHERTTFPRLARERRLAGFPLPQGAYWRAIDTAKDLTEAARELRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3B8</accession>
    <name>A0A0F7N3B8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ROK family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_14005</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ROK (NagC/XylR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016493.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_14005"/>
    <dbReference type="EnsemblBacteria" id="AKH83165">
        <property type="protein sequence ID" value="AKH83165"/>
        <property type="gene ID" value="AA958_14005"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_14005"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2948"/>
    <dbReference type="OrthoDB" id="1130699at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01125">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="3">
        <location>
            <begin position="38"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH83165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="417" mass="43306" checksum="276683E0610F5780" modified="2015-07-22" version="1">MPPPPRPSASGTPPPGTPGTPPGAPPYSPPAGQSPGEVLALISSGAAATRAEIARLTGLARSTVSQRVDALIAHGFVDEDAEAGSTGGRPPRRLSLRTREHAVAGVDLGASHCRVALLDIGGTLLAVREDPLTIADGPEAVLGHVERTMQRLLEEAGRDPKTLRSIGAGVPGPVEFSTGRPVDPPIMPGWHQFPIPEFFDERFGVRALVDNDVNVMALAEQRRAFPDTSYLLYLKVGTGIGCGIIADGRLHRGAQGSAGDIGHIRVGEREELCRCGNSGCLEAIAGGAALAVRLRELGLEASAGLDVVRLVKEGNREAVRMVREAGRAVGEVLAGLVNFFNPETVVVGGALAAVHDQLLAGVREAVYRRSHPLATHVLRIEPSRTGENAAAIGAGILAIEHALSPRQVDMALAGVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3I6</accession>
    <name>A0A0F7N3I6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Adenine phosphoribosyltransferase</fullName>
            <shortName evidence="10">APRT</shortName>
            <ecNumber evidence="5 10">2.4.2.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">apt</name>
        <name evidence="12" type="ORF">AA958_03270</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>AMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + adenine</text>
            <dbReference type="Rhea" id="RHEA:16609"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.4.2.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.7" evidence="5 10"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014721.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_03270"/>
    <dbReference type="EnsemblBacteria" id="AKH81362">
        <property type="protein sequence ID" value="AKH81362"/>
        <property type="gene ID" value="AA958_03270"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_03270"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.696"/>
    <dbReference type="OrthoDB" id="1532478at2"/>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00646"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003999">
        <property type="term" value="F:adenine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006168">
        <property type="term" value="P:adenine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00004">
        <property type="entry name" value="Aden_phosphoribosyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005764">
        <property type="entry name" value="Ade_phspho_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01090">
        <property type="entry name" value="apt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 10" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="11">
        <location>
            <begin position="49"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AKH81362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="182" mass="18972" checksum="94D1C9FF3BA5CF29" modified="2015-07-22" version="1">MSVPEGTRELLLSRIQDVPDYPQPGVMFKDITPLLADAKAFAVLTDALTEVCREQGAQKVVGLEARGFILGAPVAVRAGIGFVPIRKVGKLPGATFGQAYDLEYGTAEIEIHADAVRPGDRVLIIDDVLATGGTAEASVQLIRRAGGTVTGVAVLLELGFLAGRARVEQALAGAPLDALVTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3U7</accession>
    <name>A0A0F7N3U7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_04210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014882.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_04210"/>
    <dbReference type="EnsemblBacteria" id="AKH81527">
        <property type="protein sequence ID" value="AKH81527"/>
        <property type="gene ID" value="AA958_04210"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_04210"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.883"/>
    <dbReference type="OrthoDB" id="816674at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH81527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="411" mass="44925" checksum="290F69225974F096" modified="2015-07-22" version="1">MTACPHAADALFTPEFVANPYPAYAGLREEGRAHRVTLPGGVEAWLLTSYDDCRRAFLDNDSYSKDMAGTWTAFQEQRVPITGDVVIGMGDHMLVSDPPRHTRLKALISKAFTPRRIEALAPSIEATATGLLDGLLRRRGEDSGRADLTTEFAALLPMEVIRQLLDVPAEDGERLRHAVEAVMSNDEDSRDAAMAAFQEVHDTLRTLVARKRTEAGDDLTSALVSARDEDDRLSEDELVSMLALLLSAGHETTVNLLGSTVLALLRHPRQLALLQREPDRWAEAVEEVLRWDGPIQNAIWRFTRKPVTVGDVTIPAGEAVALSVAAADRDPDRYPDGELFDVTRGERSHLAFGHGIHHCLGAPLARLEARIAVPLVFAKLPGLALDGEPSYRPSTVSRALSSLPVTFRNAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N475</accession>
    <name>A0A0F7N475_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_04930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015002.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_04930"/>
    <dbReference type="EnsemblBacteria" id="AKH81647">
        <property type="protein sequence ID" value="AKH81647"/>
        <property type="gene ID" value="AA958_04930"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_04930"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1037"/>
    <dbReference type="OrthoDB" id="1955392at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="240" mass="24640" checksum="D577FE947E975C4A" modified="2015-07-22" version="1">MSLPGADELFRTTGGTALQSSTPQPDRQRANGEAPGGSPRVPAPSREGDAEAAGQEAEAGADGEEAGPDDAGHSGGTGEDPRARTGTGGKAGPAAPGPKRTTAPAARRDPEATEHGGREAGTEAAPGGRARQGEREPAAQARAKSARQSGGSAAAAQPRRGRGRGAARRPSGRERHDEKITVYVSAEELMDLEHARLVLRGDHGLAVDRGRIVREAVAVVLADLESRGDASILVRRLRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4D8</accession>
    <name>A0A0F7N4D8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_08420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH82253">
        <property type="protein sequence ID" value="AKH82253"/>
        <property type="gene ID" value="AA958_08420"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_08420"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1778"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="238" mass="24016" checksum="C597404114E84E07" modified="2015-07-22" version="1">MLAQHGAFGRLAGLGVERLPGRVAQHDDPAVHGVEVRQGLPQRGQAAVGHLVRDGLVPPHRALPAEAPEPQDERGGREDEGHGGHAAARTPDGFGEGGGGRAVARGLRVGGGGEAAALDGGDGGLRREEGQDSPESGGHPFTGQPPLDGPIDSVGVKGGPGTRGVAGSRRRIRPQDRCSGSRTRGACCGTSRARRRTATRPGAPVTPPRATGSCGGGHPAHTAAPAEGGPRTDSSRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4Z5</accession>
    <name>A0A0F7N4Z5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Biotin transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_09715</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the BioY family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015802.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_09715"/>
    <dbReference type="EnsemblBacteria" id="AKH82459">
        <property type="protein sequence ID" value="AKH82459"/>
        <property type="gene ID" value="AA958_09715"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_09715"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2044"/>
    <dbReference type="OrthoDB" id="1691691at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015225">
        <property type="term" value="F:biotin transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003784">
        <property type="entry name" value="BioY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34295">
        <property type="entry name" value="PTHR34295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02632">
        <property type="entry name" value="BioY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016661">
        <property type="entry name" value="BioY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="182"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR016661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH82459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="205" mass="20329" checksum="ED4D0FA31C1641B9" modified="2015-07-22" version="1">MSTAAVSSPHRARPGAVLADVLPASTAARARLRDIALVAGGAALTGAAAQFSVPVPGSPVPVTGQTFAALLVGASLGTGRAFLSLLLYAVAGVAGMPWFAEGSSGWGMPSFGYVLGMLLAAAAVGALARRGGDRDVWRTAGTMVLGSVVIYAVGVPYLALSLNVSPGEAVSLGLTPYLLGDALKAALAMGALPAAWHIAGRAHRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N586</accession>
    <name>A0A0F7N586_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chemotaxis protein CheY</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_06840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AKH81977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AKH81977">
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        <property type="gene ID" value="AA958_06840"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_06840"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1430"/>
    <dbReference type="OrthoDB" id="1950078at2"/>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
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        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
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        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="10"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH81977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="137" mass="14501" checksum="4139B8E70D07B865" modified="2015-07-22" version="1">MESTAAGPVNVLVYSDDANTREQVRLAAGRRPAADLPPVEYVECATFPAVLAELERGGIDACVLDGEAVPAGGMGVCRQIKDEIFQCPPVLLIIGRPQDAWLATWSRAEATVAHPVDPAALADGLAEVLRLRQAVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5A1</accession>
    <name>A0A0F7N5A1_9ACTN</name>
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        <submittedName>
            <fullName evidence="3">Peptidase M6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_10540</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015929.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_10540"/>
    <dbReference type="EnsemblBacteria" id="AKH82588">
        <property type="protein sequence ID" value="AKH82588"/>
        <property type="gene ID" value="AA958_10540"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_10540"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2219"/>
    <dbReference type="OrthoDB" id="461923at2"/>
    <dbReference type="Proteomes" id="UP000034283">
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Peptidase_M6-like_domain"/>
    </dbReference>
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        <property type="entry name" value="M6dom_TIGR03296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519798" evidence="2">
        <location>
            <begin position="35"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH82588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="441" mass="47776" checksum="31494DEC80313151" modified="2015-07-22" version="1">MEQDQSRALHRAAAVATSLSAVMATSLIADPVGAQPGHPCALERTAAHHSEGIAGWDPAYPRPKKTLDAVMVYLSFPDSEPLTSPDELTGDHFPATAEFFERASYGQFRLRVDARERWIRMPSDSLSYGIARDWDPTARSRFLNDAVSAADRKVDFRDYDVVYLVADPDAPGVDSDATKVVNFETPMRADGTDLHRIVTVFEQHPPDRNVLAHETGHVFDLPDLYHRPLDGRADWDTHVGDWDLMGSQFGLAPDPFGWHKWKLGWLGDDQVGCAANPGSDRFTLHALSAPTSPRTPPRGTTETQAENGAGELREQGGNGKGAAVLRRDTRLVVVPTGATTAVAVEARGRYANDRHACTEGVLVYRVHTGTDSGGGPVEVVDGHPRTAACHDTSVYPPLADAPLGEGESLELKREGVRVEVTGRMADGGWGVRVVRGAAKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5E9</accession>
    <name>A0A0F7N5E9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PAP2_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_07190</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
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            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP011492">
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    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_07190"/>
    <dbReference type="EnsemblBacteria" id="AKH82042">
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    </dbReference>
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    <dbReference type="PATRIC" id="fig|444103.5.peg.1506"/>
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    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026841">
        <property type="entry name" value="Aur1/Ipt1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14378">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="9"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="212"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="PAP2_3" evidence="6">
        <location>
            <begin position="44"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH82042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="244" mass="27520" checksum="D90F756FDCD5233C" modified="2015-07-22" version="1">MRSPRPPRLWFEIMLVALVYWTYSLIRNAVPEQETQALKNADRIWSFQESLGMAFERSLNHAVDGVTWLVVSMNYYYGTLHYVVTLGVLVWLYRWQPGRYAAVRLALAITTCFALVGYYSFPLAPPRLMEGMDFVDTVRVHETWGSMSSGNLANVSNQYAAMPSMHVGWSVWAGITIAVLAKPLWVKLLGVLYPTLTLLVIMATANHFWMDAVGGVICLTFGFAVSYAWYGTIAYRLPQKVASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5G5</accession>
    <name>A0A0F7N5G5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_15005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83311.1"/>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
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        <property type="protein sequence ID" value="AKH83311"/>
        <property type="gene ID" value="AA958_15005"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_15005"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3162"/>
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    <dbReference type="Proteomes" id="UP000034283">
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    </dbReference>
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        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
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        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="41"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="289" mass="30019" checksum="D243746F5938E70F" modified="2015-07-22" version="1">MDTHTLNLPGADLVYDVRGPLPTADGRPPLLLIGQPMDAGGFRALAAQFTDRTVVTYDPRGLGRSTRKDGRHDHNPQTQAEDVHALIAALGAGPVELFGSSGGAVTALALVTAYPEDVTTLVAHEPPIIPALPDAEAAERARQGVTDAYNAKGWGTGMAAFMGLGAWQGEFTDAYFAQPAPDPAAFGMPADDDGNRDDPLLSDASWAVSGYRPDPAALAAAPTRVVIAVGEESGDTFTARTARGTAALLGQEATVFPSHHGGFLDAEYGYAGRPEAFGAKLREVLDASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5Y4</accession>
    <name>A0A0F7N5Y4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Phosphomethylpyrimidine synthase</fullName>
            <ecNumber evidence="10">4.1.99.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Hydroxymethylpyrimidine phosphate synthase</fullName>
            <shortName evidence="10">HMP-P synthase</shortName>
            <shortName evidence="10">HMP-phosphate synthase</shortName>
            <shortName evidence="10">HMPP synthase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Thiamine biosynthesis protein ThiC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">thiC</name>
        <name evidence="13" type="ORF">AA958_15870</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + S-adenosyl-L-methionine = 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + 5'-deoxyadenosine + CO + formate + 3 H(+) + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:24840"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:17245"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58354"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="EC" id="4.1.99.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="10">Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Cofactor biosynthesis; thiamine diphosphate biosynthesis.</text>
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        <text evidence="10">Belongs to the ThiC family.</text>
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</entry>
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                <person name="Kalinowski J."/>
                <person name="Heide L."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
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</entry>
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        <lineage>
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                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
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                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045190">
        <property type="entry name" value="MCCB/AccD1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22855">
        <property type="entry name" value="PTHR22855"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="2">
        <location>
            <begin position="28"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="3">
        <location>
            <begin position="284"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH82557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="546" mass="57616" checksum="E3C786B0A7F7947F" modified="2015-07-22" version="1">MDHAPALTTAADPSGPAGAAWRTNEAAHRALAGELYDKLAAARAGGGEKARARHTARGKLLPRDRVDGLLDPGSPFLELAPLAADGMYGGGAPAAGVIAGIGRVSGRACVVIANDATVKGGTYYPMTVKKHLRAQEIALENRLPCVYLVDSGGAFLPMQDEVFPDREHFGRIFYNQARMSGAGIPQIAAVLGSCTAGGAYVPAMSDEAVIVRGQGTIFLGGPPLVKAATGEVVTAEELGGGEVHARTSGVTDHLAEDDPHALRIVRGIVDTLPEPGPPPWSVRAPEEPKHDPAGLYGVVPVDSRTPYDVREVIARVVDGSRFQEFKAEYGTTLVTGFARIHGHAVGIVANNGILFSESAQKGAHFIELCDQRGIPLLFLQNISGFMVGRSYEAGGIAKHGAKMVTAVACTRVPKLTVVIGGSYGAGNYSMCGRAYSPRFLWMWPNAKISVMGGEQAASVLATVKRDQLEARGEEWSAAAETEFKAPIREQYETQGNAYYATARLWDDGVIDPLDTRRVLGLALTACAHAPLPARDGAAQGFGVFRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6X4</accession>
    <name>A0A0F7N6X4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_13815</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016462.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_13815"/>
    <dbReference type="EnsemblBacteria" id="AKH83133">
        <property type="protein sequence ID" value="AKH83133"/>
        <property type="gene ID" value="AA958_13815"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_13815"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2909"/>
    <dbReference type="OrthoDB" id="384611at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="5">
        <location>
            <begin position="27"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="253"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH83133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="485" mass="51835" checksum="D7CF2ECF45216429" modified="2015-07-22" version="1">MSLFSDLALQYIDGKWCPGAGSWDVIDLDPYTGEQLAAVTVATAAEVDAAYRAAERAQRPWAERSPYERRLVFERALRLVEEREEEITRAIVAELGGTRLKAAFEIALTRDVLRESVSYALRAEGRVLPSPTPGKENRVYRLPVGVVGVIGSYDFPLFLAAKSVAPALALGNAVVLKPHDYSPVVGGTLLAWLLQDAGLPPGLLNVVITDTSEIGDAFLEHPVPRVLSFTGSTETGRHVAGVAARHFKRTVLEMSGNAALVVLDDADVDYAVDAAVFSRFAHQGQVCMAANRVLVDRAVLPEFAAKFVAKAAALKTGDPSDPATQLGPLIGAREAADLAARVDAALAAGATALLRGRTEGTLVEPTVLTGLPADSELLRREFYGPVAFLLPFTGEDEAVRIVNDTPFGLSGAVHTRDLERGVRLAGRIDSGMVHVNDGTIHDEPLVPFGGEKCSGLGRLNGESTVDAFTTLKWISVQHGRTPFPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N714</accession>
    <name>A0A0F7N714_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_14145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016511.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH83183">
        <property type="protein sequence ID" value="AKH83183"/>
        <property type="gene ID" value="AA958_14145"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_14145"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2977"/>
    <dbReference type="OrthoDB" id="1819226at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="115" mass="12805" checksum="0D6B70B8E617F179" modified="2015-07-22" version="1">MIGRPDVPVRLLPWTSLEGKPCYLLGGGSGYVSRIADDMERVQLKMAVELLGHATCMLDDDTTTLPQFRYLVARMAESLSDLHRVAESRGARIPALGDEDDEIDENNEIDDEEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7E3</accession>
    <name>A0A0F7N7E3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_22540</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017774.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_22540"/>
    <dbReference type="EnsemblBacteria" id="AKH84515">
        <property type="protein sequence ID" value="AKH84515"/>
        <property type="gene ID" value="AA958_22540"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_22540"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4743"/>
    <dbReference type="OrthoDB" id="1762196at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519139" evidence="2">
        <location>
            <begin position="20"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH84515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="201" mass="21073" checksum="0C42B05CC4692587" modified="2015-07-22" version="1">MSMRGTSRARRAAATVALAAALALTAAGCGSGGDDVDGGAKSSDTSETSGGGDSDAKGEGQQDAGDEEVPSEPIAEVKNKEGIVLRILELKRDGGGFVTLNGELENTGTEDFLHIQDWSGREQGADKSSLMGATFVDSEGKKRYYALRDTEMRCLCTSGIASLDAGETLTVYIQFPAPPDETTEVEFQLPTFPPSNLEISE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7G4</accession>
    <name>A0A0F7N7G4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Potassium-transporting ATPase KdpC subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">ATP phosphohydrolase [potassium-transporting] C chain</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Potassium-binding and translocating subunit C</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Potassium-translocating ATPase C chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">kdpC</name>
        <name evidence="12" type="ORF">AA958_15130</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP-binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB/KdpC/ATP ternary complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">The system is composed of three essential subunits: KdpA, KdpB and KdpC.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell membrane</location>
            <topology evidence="11">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the KdpC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016643.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_15130"/>
    <dbReference type="EnsemblBacteria" id="AKH83329">
        <property type="protein sequence ID" value="AKH83329"/>
        <property type="gene ID" value="AA958_15130"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_15130"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3188"/>
    <dbReference type="OrthoDB" id="1912405at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008556">
        <property type="term" value="F:P-type potassium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00276">
        <property type="entry name" value="KdpC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003820">
        <property type="entry name" value="KdpC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30042">
        <property type="entry name" value="PTHR30042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02669">
        <property type="entry name" value="KdpC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001296">
        <property type="entry name" value="K_ATPase_KdpC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00681">
        <property type="entry name" value="kdpC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 11" id="KW-0630">Potassium</keyword>
    <keyword evidence="3 11" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 11" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AKH83329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="203" mass="21330" checksum="2FA6561C2C4661FD" modified="2015-07-22" version="1">MNTSARSTARLLVSALRALLVLTVVTGVIYPLVITGIAQGAFAGKANGSKAEFEGREAGSKLIGQNWNLKGTETPDPRWFQPRPSNSAYDPLATGPSNLGASDATLVKTVKEAKQQVASFNDVPVSEVPKDAVTGSGSAIDPHISPAYAEIQVNRVAQENGLGAAQVENLVNAHKEGRDLGFLGNEKVNVLELNLALSRLADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7G7</accession>
    <name>A0A0F7N7G7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF2154 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_22670</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017798.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_22670"/>
    <dbReference type="EnsemblBacteria" id="AKH84540">
        <property type="protein sequence ID" value="AKH84540"/>
        <property type="gene ID" value="AA958_22670"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_22670"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4769"/>
    <dbReference type="OrthoDB" id="1687355at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012551">
        <property type="entry name" value="DUF1707"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024425">
        <property type="entry name" value="DUF2154"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08044">
        <property type="entry name" value="DUF1707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09922">
        <property type="entry name" value="DUF2154"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2154" evidence="2">
        <location>
            <begin position="115"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH84540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="229" mass="24354" checksum="61DD7C13F65931F1" modified="2015-07-22" version="1">MDETPRDNAPVPAAQPSLSKKPVAEGELRASDADRDRVADILREALAEGRLDPEEHAERIDGVYTAKTVGELEPLVRDLPAGRRAPGPAAPPPPSPYPQPQPQTLVAIFSGSTRKGRWSVGRRTSAFALFGGVDIDLTEAVFHQQEIVINATAIFGGVDIKVPANVSLRGSGTAIFGGFDVHAQEADDPRAPVVVVTGFALFGGVDAKGKKGKFLKNLTDRMRKHGLGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7J3</accession>
    <name>A0A0F7N7J3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_15255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018836497.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_15255"/>
    <dbReference type="EnsemblBacteria" id="AKH83348">
        <property type="protein sequence ID" value="AKH83348"/>
        <property type="gene ID" value="AA958_15255"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_15255"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3213"/>
    <dbReference type="OrthoDB" id="1893426at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014447">
        <property type="entry name" value="UCP006909"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006909">
        <property type="entry name" value="UCP006909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="98" mass="11401" checksum="E5F3B0328E98B6A4" modified="2015-07-22" version="1">MIFKRIGNGRPYPHHGRESTRQWADVAPRPVRLDQLVTTKQQLDLETLLAEDSTFYGDLFAHVVKWRGDLYLEDGLHRAVRAALQQRQVLHARVLELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8G9</accession>
    <name>A0A0F7N8G9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Coenzyme F420 biosynthesis-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_18075</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017098.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_18075"/>
    <dbReference type="EnsemblBacteria" id="AKH83798">
        <property type="protein sequence ID" value="AKH83798"/>
        <property type="gene ID" value="AA958_18075"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_18075"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3801"/>
    <dbReference type="OrthoDB" id="1070352at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.150.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022454">
        <property type="entry name" value="CHP03883_F420-assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018766">
        <property type="entry name" value="Zinicin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042271">
        <property type="entry name" value="Zinicin_2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39420">
        <property type="entry name" value="PTHR39420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10103">
        <property type="entry name" value="Zincin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03883">
        <property type="entry name" value="DUF2342_F420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03624">
        <property type="entry name" value="TIGR03624"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH83798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="384" mass="41982" checksum="7D88AD7A5AE8CE6B" modified="2015-07-22" version="1">MTSIGGAEMVDWNLAVATATRLVRPGPEVSRDEARAIVGELRAHARSAEEHVREFSRMYPEGADPRHDTPILVVDRPGWIKANVAGFRAVLAPLLEKMDKRRSGLPGGAVLGAVGGKITGVELGMLLSFLSSRVLGQYETFAPATRDLPGGPAAHAGSGSGGAGQGRLLLIAPNIVHVERELEVAPHDFRLWVCIHEETHRTQFTAVPWLRDHLQGEIQSFLGETEIDPATLLDRVREALQSLSGSREEGGEERSIVEVVQTPAQREILGRLTAVMSLLEGHADYVMDGVGPQVVPSVSEIREKFTKRRQAGAGRLDQALRKLLGLDAKLRQYRDGERFVRHVVDQVGMDGFNRVWTSPNTLPTKAEIAKPADWIARVHSRAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8I7</accession>
    <name>A0A0F7N8I7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">L-aspartate oxidase</fullName>
            <ecNumber evidence="4 11">1.4.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">AA958_18225</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the oxidation of L-aspartate to iminoaspartate, the first step in the de novo biosynthesis of NAD(+).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-aspartate + O2 = H2O2 + iminosuccinate</text>
            <dbReference type="Rhea" id="RHEA:25876"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
            <dbReference type="EC" id="1.4.3.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:25877"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Cofactor biosynthesis; NAD(+) biosynthesis; iminoaspartate from L-aspartate (oxidase route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.16" evidence="4 11"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017123.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_18225"/>
    <dbReference type="EnsemblBacteria" id="AKH83823">
        <property type="protein sequence ID" value="AKH83823"/>
        <property type="gene ID" value="AA958_18225"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_18225"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3832"/>
    <dbReference type="OrthoDB" id="153138at2"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00326"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008734">
        <property type="term" value="F:L-aspartate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044318">
        <property type="term" value="F:L-aspartate:fumarate oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033765">
        <property type="term" value="F:steroid dehydrogenase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037099">
        <property type="entry name" value="Fum_R/Succ_DH_flav-like_C_sf"/>
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    <dbReference type="InterPro" id="IPR015939">
        <property type="entry name" value="Fum_Rdtase/Succ_DH_flav-like_C"/>
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    <dbReference type="InterPro" id="IPR005288">
        <property type="entry name" value="NadB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42716">
        <property type="entry name" value="PTHR42716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02910">
        <property type="entry name" value="Succ_DH_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46977">
        <property type="entry name" value="SSF46977"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="SSF56425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00551">
        <property type="entry name" value="nadB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0274">FAD</keyword>
    <keyword evidence="5 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6 11" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="13">
        <location>
            <begin position="18"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="Succ_DH_flav_C" evidence="14">
        <location>
            <begin position="441"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="537"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AKH83823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="576" mass="59935" checksum="FBCB7CCFE9DE3D00" modified="2015-07-22" version="1">MTAIRLGAPAPGWVLDTDVVVVGSGVAGLTAALRCAEAGLRVAVVTKANFDDGSTRWAQGGIAAALGDGDSPEQHLADTLVAGAGLCDEDAVRTLVTEGPAAVRRLIATGAAFDTDPATGAIELTREGGHHRRRIAHAGGDATGAEVSRALVQAVREAGIETVEHALVLDLIKDAEGRAAGVTLHVMGEGARDGVGAVHAPAVVLATGGMGQVFSATTNPAVSTGDGVALALRAGAEVSDLEFVQFHPTVMFLGPDAEGQQPLVSEAVRGEGAHLVDAGGVRFMVGQHELAELAPRDIVAKGITRRMREQGADHMYLDGRHFGAEMWKQRFPTIFAACRAHGFDPVHDLVPVAPAAHYASGGVVTDLRGRTSVPGLYACGEVACTGVHGANRLASNSLLEGLVFAERIAADVAAAPVRAEPAAPEEKRPPLEIPLLPQDARADIQRVMTAGAGVLRSAASLDGAASALGAIRDTARPAPAAPCVETWEATNLLLVAQVLVECARRRAETRGSHWREDHADRDDARWARHFLVTLTYDPVRPESPESPESPESPEDPAHPALAVRTTAGTAFHRETP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8J8</accession>
    <name>A0A0F7N8J8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">D-inositol-3-phosphate glycosyltransferase</fullName>
            <ecNumber evidence="7">2.4.1.250</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">N-acetylglucosamine-inositol-phosphate N-acetylglucosaminyltransferase</fullName>
            <shortName evidence="7">GlcNAc-Ins-P N-acetylglucosaminyltransferase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mshA</name>
        <name evidence="10" type="ORF">AA958_13520</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2-acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>1D-myo-inositol 3-phosphate + UDP-N-acetyl-alpha-D-glucosamine = 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside 3-phosphate + H(+) + UDP</text>
            <dbReference type="Rhea" id="RHEA:26188"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58401"/>
            <dbReference type="ChEBI" id="CHEBI:58892"/>
            <dbReference type="EC" id="2.4.1.250"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyltransferase group 1 family. MshA subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.250" evidence="7"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016412.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_13520"/>
    <dbReference type="EnsemblBacteria" id="AKH83082">
        <property type="protein sequence ID" value="AKH83082"/>
        <property type="gene ID" value="AA958_13520"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_13520"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2845"/>
    <dbReference type="OrthoDB" id="694191at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008375">
        <property type="term" value="F:acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102710">
        <property type="term" value="F:D-inositol-3-phosphate glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010125">
        <property type="term" value="P:mycothiol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01695">
        <property type="entry name" value="MshA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017814">
        <property type="entry name" value="Mycothiol_biosynthesis_MshA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03449">
        <property type="entry name" value="mycothiol_MshA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="9">
        <location>
            <begin position="38"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="8">
        <location>
            <begin position="234"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="UDP-GlcNAc binding" evidence="7">
        <location>
            <begin position="32"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="1D-inositol 3-phosphate binding" evidence="7">
        <location>
            <begin position="37"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>1D-myo-inositol 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58401"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>1D-myo-inositol 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58401"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>1D-myo-inositol 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58401"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>1D-myo-inositol 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58401"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>1D-myo-inositol 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58401"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="328"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="329"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="331"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="349"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="355"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AKH83082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="447" mass="46529" checksum="A2F51BE783709957" modified="2015-07-22" version="1">MSHHLSRLRALARHRRPRRVAMLSVHTSPLHQPGTGDAGGMNVYIVELARRLAEIGVEVEVFTRAASAGLPPAVELAPGVLVRHVAAGPYEGLAKEDLPAQLCAFTHGVMQAEAGHRPGYYDLVHSHYWLSGQVGWLAAERWGVPLVHAMHTMAKVKNAALATGDSAEPPARVIGESQVVRAADRLIANTDDEAHDLVRHYDADPARVAIVRPGVNLDVFRPGGPEGPAGSRARARAALGLPQDAFVPLFAGRIQPLKAPDVLLRAVALLLERDPALRERLVVPVVGGPSGTGLARPAALQKLAAKLGISDVVRFTPPVAQQALARWFRAASVLVMPSYSESFGLVALEAQACGTPVVAAAVGGLPVAVRDGVTGLLVDGHDPADFADALGRLAADAALAGRMGAAAAGHAAGFGWDAAARATADVYAAAIAGYSHAVAPRLPSPHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8Q3</accession>
    <name>A0A0F7N8Q3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_21995</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017683.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH84421">
        <property type="protein sequence ID" value="AKH84421"/>
        <property type="gene ID" value="AA958_21995"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_21995"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4632"/>
    <dbReference type="OrthoDB" id="1914729at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="30"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="7">
        <location>
            <begin position="131"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="185"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH84421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="214" mass="23101" checksum="2408ADC5369671DE" modified="2015-07-22" version="1">MQGEYAEDAALSGAVHAAQRGDEAAFRIVFRTVHPRLLGYVRSLVGDGDAEDVTSEAWLQIARDLGSFSGDADRFRGWAARIARNRALDHVRMRSRRPVSGGDETQLADRPADSDTAEEAIEALGTGRTMAFIARLPRDYAEVVVLRVIMGLDAKRTAEVLGKSPGAVRTAAHRGLKQLTALIERPQEEGDVPPGEGQQPGGVTQSAARTLKEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N965</accession>
    <name>A0A0F7N965_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ArsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_14825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016597.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_14825"/>
    <dbReference type="EnsemblBacteria" id="AKH83282">
        <property type="protein sequence ID" value="AKH83282"/>
        <property type="gene ID" value="AA958_14825"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_14825"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3124"/>
    <dbReference type="OrthoDB" id="1617768at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="102" mass="11253" checksum="6E934D22D67F17AF" modified="2015-07-22" version="1">MGDPTRRAIMTCLAERERAVGELADELPISRPAVSQHLKVLKNAGLVTERTAGTRRIYRLNPAGVAALRDQLETFWSRALAGYREAAEDHDNGKEAHGEEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9F1</accession>
    <name>A0A0F7N9F1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_26375</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018411.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_26375"/>
    <dbReference type="EnsemblBacteria" id="AKH85170">
        <property type="protein sequence ID" value="AKH85170"/>
        <property type="gene ID" value="AA958_26375"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_26375"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5552"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018391">
        <property type="entry name" value="PQQ_beta_propeller_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002372">
        <property type="entry name" value="PQQ_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13360">
        <property type="entry name" value="PQQ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00564">
        <property type="entry name" value="PQQ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="SSF50969"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="35"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH85170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="754" mass="77095" checksum="48643266F475D09F" modified="2015-07-22" version="1">MQTLTGSGGHTGGATGTTVGGQERVGPHRIVAPLGTSGPEAGSGAGGPRFHLAYSEPLGRVVVLMTPPEALAADPGFRVRFASEAGTSARLAGPAAAPVAGVAPQDEEPWVAYDCAPALPLPAALAAQGGPLPVPYVCQLGVSLAAAVLQAHAQGLVYAGLTPAAVLLTAAGPRLVAYGAVRAAAPGDGPRTAVPGLPPAWLPPEQHAGGVPRPLGDVYALGVVLAYAATGAHSPDPAALPEPLASVLAGCLARDPAQRPRADALLQQLQQAQQALSAEPGQQQVPGAVAAALTAQLPSLPAQGPLAPPPGPGEPGGPGGPPAPGQTPETSAGAGAGETSVPPPRPGRRALLRGLAFGAAGLAAGGGGVYAYRRATKEDPPVYRTTPAKGAAPTPLWHYSLQGQEADSISLLGKIAVVETMGALTAVNVRTGKKAWDSDVFADGGLFDLGRGQVLLIPMFGPMEVVDIAGGKSKGAIEDYAVDGKLSFQEAVGAVDGIVYFLATRGSDMEEFSMVAYDTRKGEEVWNKPLPEGYGDLNDNPLSDGERMKIRGRELLIPSAPTSGFDFSYLALDRRSGDKAWEQKFAGIEDYDGPSTFATGAGILVSPKNEGDTLRGFEMRGAKKLWEHPMKEHFSGELTDTRSRVLYGTQGAEVTALSVKNGKRVWRTPVYSGGRFDVTDVVLSGTGGTLFYSNDAEVQAFDTRDGAPLWRFATVSEGGGSSGDGTGVSGRVLAADDGIALVLSKDALYALPVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9G6</accession>
    <name>A0A0F7N9G6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_19985</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017374.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_19985"/>
    <dbReference type="EnsemblBacteria" id="AKH84084">
        <property type="protein sequence ID" value="AKH84084"/>
        <property type="gene ID" value="AA958_19985"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_19985"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4210"/>
    <dbReference type="OrthoDB" id="1358015at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH84084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="174" mass="18654" checksum="A05396FEDB72FC59" modified="2015-07-22" version="1">MADVTGRGYRYVGPVELKAAVRPGGGGRRIGSAADFDGWIMEQSAVELAEPFTFVVGRDGVLRLAPRRSEHVACAGGDMVLSAGEISFVREADRWAVSEVSNQSTGYCPDVDSWAEVARALDAAGLRRPSGFTHEVVFRRCPGCQERTIVREDDFVCVFCGTDLPAEGNVGPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9M8</accession>
    <name>A0A0F7N9M8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_20335</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017433.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH84144">
        <property type="protein sequence ID" value="AKH84144"/>
        <property type="gene ID" value="AA958_20335"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_20335"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4283"/>
    <dbReference type="OrthoDB" id="1908941at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH84144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="97" mass="11412" checksum="1C5B46C47390214F" modified="2015-07-22" version="1">MTFVQLIEYESDHPEELGRAMDEWMTATEGKRTMSREIHGRDRESSRHFVDIVEFPSYEQAMVNNDLPETQRVAAQFRELCTSEPRFVDLDVVDDRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9Y1</accession>
    <name>A0A0F7N9Y1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_16280</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016813.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_16280"/>
    <dbReference type="EnsemblBacteria" id="AKH83507">
        <property type="protein sequence ID" value="AKH83507"/>
        <property type="gene ID" value="AA958_16280"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_16280"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3430"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="446"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="9"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="279"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="362"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="404"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH83507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="468" mass="47875" checksum="410ED7967F4D3F5A" modified="2015-07-22" version="1">MGEVFAGRYELIDPIGRGGVGAVWRAWDHRRRRYVAAKVLQQSDAHTLLRFVREQAVRIDHPHVLAPASWAADDDKVLFTMDLVGGGSLAHLIGDYGPLPPRFVCLLLDQLLAGLAAVHGENVVHRDIKPANVLLEATGTGRPHLRLSDFGISMRKGEPRLTDTNFVVGTPGYFAPEQMLGAEPDFPADLFAVGLLALYLLTGERPDSQALVEMYLKNGVPPAPKDVPEPLWQVLASLLQPDPEMRFRTATGTRKALAEAAELLPELDPAEEPVEVFDQLGPLPVGFGPRGPERAQERAAEAAPGPGPGLGAGAGLGPGAGAGPGPGAGFGPGTGTGPAGDAGAAGPAGPAYAPPGGAGYVPPPAAAAPEPGTAGPGTAHPPAAGPPGPGDPAEATSYGIAPPAASQPPTPTAPYTTARPQPRSQPPQPRPGAAVPQRRPGPPAKVAIPVAVLAVLLMAAGVWALVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NA08</accession>
    <name>A0A0F7NA08_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_24610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018113.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_24610"/>
    <dbReference type="EnsemblBacteria" id="AKH84861">
        <property type="protein sequence ID" value="AKH84861"/>
        <property type="gene ID" value="AA958_24610"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_24610"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5190"/>
    <dbReference type="OrthoDB" id="1688794at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="227" mass="23997" checksum="C794ACACFAA39A37" modified="2015-07-22" version="1">MTDHDAAQNAGPAPLDRFVRLCVPLTGFTAYELRSTGMAQLYFDTARREIGHRSLDAFLGVWEEAHKGGLGPSRLPALERELARALIYLWYTGAFPRIAPAAHAELRRDRPNQEFVASPESYPEGLVWRAFGGHPAGAKPPGFGTWGDEPPELPTEAELAARIAAEDAGHGGAVPYDAGSYGSAGEAGGSTPAHLLPGPRSSRAVSPSAVPPASSHPVRETSPEAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NA26</accession>
    <name>A0A0F7NA26_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">Ornithine carbamoyltransferase</fullName>
            <shortName evidence="6">OTCase</shortName>
            <ecNumber evidence="3 6">2.1.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AA958_27695</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>carbamoyl phosphate + L-ornithine = H(+) + L-citrulline + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19513"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="EC" id="2.1.3.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.3" evidence="3 6"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018624.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_27695"/>
    <dbReference type="EnsemblBacteria" id="AKH85390">
        <property type="protein sequence ID" value="AKH85390"/>
        <property type="gene ID" value="AA958_27695"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_27695"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5836"/>
    <dbReference type="OrthoDB" id="988597at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004585">
        <property type="term" value="F:ornithine carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1370">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01109">
        <property type="entry name" value="OTCase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006132">
        <property type="entry name" value="Asp/Orn_carbamoyltranf_P-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006130">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036901">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006131">
        <property type="entry name" value="Asp_carbamoyltransf_Asp/Orn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002292">
        <property type="entry name" value="Orn/put_carbamltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024904">
        <property type="entry name" value="OTCase_ArgI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00185">
        <property type="entry name" value="OTCace"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02729">
        <property type="entry name" value="OTCace_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00100">
        <property type="entry name" value="AOTCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00102">
        <property type="entry name" value="OTCASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53671">
        <property type="entry name" value="SSF53671"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00658">
        <property type="entry name" value="orni_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00097">
        <property type="entry name" value="CARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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</entry>
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</entry>
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    <accession>A0A0F7NAA4</accession>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="11 12">CNQ-509</strain>
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</entry>
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    <reference evidence="4 5" key="1">
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            <authorList>
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
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                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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            <end position="32"/>
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            <begin position="33"/>
            <end position="438"/>
        </location>
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            <end position="132"/>
        </location>
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            <end position="166"/>
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            <begin position="210"/>
            <end position="228"/>
        </location>
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            <end position="251"/>
        </location>
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            <begin position="263"/>
            <end position="284"/>
        </location>
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        <location>
            <begin position="296"/>
            <end position="320"/>
        </location>
    </feature>
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            <begin position="49"/>
            <end position="73"/>
        </location>
    </feature>
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        <location>
            <begin position="356"/>
            <end position="438"/>
        </location>
    </feature>
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        <location>
            <begin position="358"/>
            <end position="373"/>
        </location>
    </feature>
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        <location>
            <begin position="392"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH83782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="438" mass="44630" checksum="0F3130BA594E2E9F" modified="2015-07-22" version="1">MPADRRRPALRLGALLGGAQFVALLAAGRAAAQDGDSCDLIRGPARDYCEGEGDRQGSAPDAPSDPTESVDPLSSLAKGCAEAAAWTIDKLSDAVNSTTTVDFTNATFLRQYAVVFAASTILTLTLWLLAVAKRAIRGVPLGEALGEAIGFLWLTVLASAFTPLVLYTLVTATDSVTEAIASGTSSNTDTFFGGFSEALKKGEDIGGGPIMLIVVSLVSVLAAGVLWLELVIRAALLYVGALLGTAVYAGLVDKNMWHHVRRWAGIMIAVILVKPVIVIVLGLAGALSAEEGPDAFSAVVSGLAIILLAIFASAMIYRFVPGFGDEIMTAKQGRRATSANPASAVMATPAALVTAGMKTHGSRTSSSGPAGGATGESRSAAKPANPVAGGVSAHSTRPQQSAPPKPSTANHSTGGSGSGSQGGRSVPPQSAQQPGNRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAR7</accession>
    <name>A0A0F7NAR7_9ACTN</name>
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        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
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            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
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    <dbReference type="EnsemblBacteria" id="AKH84554">
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
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        </location>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AKH84554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="472" mass="47925" checksum="ED7E0B1AB6460D50" modified="2015-07-22" version="1">MTTTRRHPGWTLTLLAFAQLIISIDYNIVYVALPEIGSALGFSAHSLQWVISGYAVAFGGFLLLGGRASDLFGPRRMFVLGLSLYAASSLAGGLAWDPWVLIAARAVQGIGGAFLFPATLTLVGTSFAEGRERNRAFAVWGTAGGSGMILGSLLGGVLTDAFGWAAVFYVNVPLATIAALCALPLLALDAVRRAAGRRFDAAGALTATAGTTLVVFALVQGPEAGWTATPVVLAAFVGIALLTAFAVVEKRGADPLTPPRLLRHRNLTTAMAVTFGFMATLGTLLYFLTVYFQTVHGYSALRTGLAFLVPMLAIAAGSQTAGRLATRYGLRPTMITALAVAAAGTALTALPMATDASYISLIPGLVVLGLGQGAGYSLMFGAAGNGVPAQQQGIAAGLASTTQQIGGAVGLAVLVAIAGPAGSVDGLRDAMFAAAAAATATALVALRFSRPARQPAAEAAPATRGRDAVGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAS1</accession>
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        <recommendedName>
            <fullName evidence="2">BTAD domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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    <dbReference type="EnsemblBacteria" id="AKH84593">
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        <property type="gene ID" value="AA958_23005"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_23005"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4848"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
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    </dbReference>
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        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-0902">Two-component regulatory system</keyword>
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        <location>
            <begin position="99"/>
            <end position="240"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM01043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH84593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="249" mass="27536" checksum="045FE3EA072C37E3" modified="2015-07-22" version="1">MYRNRFTIRLLGTFEVARDGSAPIRLWPKPRALLAQLLVADAPVPMRRIVAELWPREAPESATVNVRGYVHLIRRALGTDAVQTLHDGVYAVRLPGAQVDYRMFLDLLDRSRTTDVPPERIIHLKRALALCGGPVLSDVPHGPMLGNWVASVQDHRRRALLELAALLIHGGRCDDAQRLLRSHLLEQAADETAYMLLMQALYAAGDGGAALAVYRQAYRELARIGMLPGPRLSALQDAVLHHHPLPAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NB09</accession>
    <name>A0A0F7NB09_9ACTN</name>
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        <submittedName>
            <fullName evidence="2">Iron ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">AA958_29525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_29525"/>
    <dbReference type="EnsemblBacteria" id="AKH85690">
        <property type="protein sequence ID" value="AKH85690"/>
        <property type="gene ID" value="AA958_29525"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_29525"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6230"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="1">
        <location>
            <begin position="26"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="279" mass="30170" checksum="D044D04153720D4C" modified="2015-07-22" version="1">MKPVAQADRVTDVRGVEVAPARVPKRIVCLVALCDDMLTELGMVPAATNSEILAHPDFLGGEKAAKVPVIPGGFIAPEVEAILSHEPDLVIGLEDTHGKLAPALKGATTFWPVQPQDWQDSVSYLRDLAALTGRGERAVAAEKRFRGKLERAQESRSEKTALVIFGSDANFGVAAPGRDIAAGLFPQIAEYPWRDRGVEGTYSLEEILAREVDVLFVETIAFGDAEVKLSEKMAENPLWAQIPAVRDNKVIEVDPEVWAKGRGTRSLGIVLDEATAALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NB24</accession>
    <name>A0A0F7NB24_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_23320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017905.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_23320"/>
    <dbReference type="EnsemblBacteria" id="AKH84649">
        <property type="protein sequence ID" value="AKH84649"/>
        <property type="gene ID" value="AA958_23320"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_23320"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4916"/>
    <dbReference type="OrthoDB" id="1804797at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="172" mass="18152" checksum="8CD9745F5AF8EC43" modified="2015-07-22" version="1">MEPIAAALAEEAARKSGLVWIEGPDGTQRALWHVWHDGAVVLVGDGPAEQPLDGLGLADGAVVTVHARSKDKGGRLVAWPARVTELVPEGEAWRAAVEELKGKRLNAVDADHVAARWARECRVLRLARDGAAVAGDGLPSGSLAAPPPATPATTRRPAPAALPRLLFRRRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NB27</accession>
    <name>A0A0F7NB27_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Gluconokinase</fullName>
            <ecNumber evidence="4 9">2.7.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AA958_18570</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + D-gluconate = 6-phospho-D-gluconate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19433"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18391"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate acid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the gluconokinase GntK/GntV family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.12" evidence="4 9"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017174.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_18570"/>
    <dbReference type="EnsemblBacteria" id="AKH83877">
        <property type="protein sequence ID" value="AKH83877"/>
        <property type="gene ID" value="AA958_18570"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_18570"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3897"/>
    <dbReference type="OrthoDB" id="1843451at2"/>
    <dbReference type="UniPathway" id="UPA00145">
        <property type="reaction ID" value="UER00565"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046316">
        <property type="term" value="F:gluconokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02021">
        <property type="entry name" value="GntK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031322">
        <property type="entry name" value="Shikimate/glucono_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006001">
        <property type="entry name" value="Therm_gnt_kin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43442">
        <property type="entry name" value="PTHR43442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01202">
        <property type="entry name" value="SKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01313">
        <property type="entry name" value="therm_gnt_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AKH83877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="186" mass="19760" checksum="E72B5597D90EF5C8" modified="2015-07-22" version="1">MSPPSTHRRATPGTHTGLVVMGVSGAGKSTVARLLADRLGWALAEADDFHPRTNIAKMRAGTPLTDADREPWLRAIAAWLAGWADAGENAVVTCSALKRAYRDILREAGPRVRFVHLHGDNDTLARRLGGRSGHFMPPALLDSQLADLEPLAGDEDGVAVDIGGTPEEVAEESLRRLGLPQPPPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBQ7</accession>
    <name>A0A0F7NBQ7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ferritin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_24600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018111.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_24600"/>
    <dbReference type="EnsemblBacteria" id="AKH84859">
        <property type="protein sequence ID" value="AKH84859"/>
        <property type="gene ID" value="AA958_24600"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_24600"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5188"/>
    <dbReference type="OrthoDB" id="935353at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026820">
        <property type="entry name" value="VioB/RebD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12902">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ferritin-like" evidence="2">
        <location>
            <begin position="25"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="365"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH84859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="391" mass="43596" checksum="C4D72A93F8EB0054" modified="2015-07-22" version="1">MTTMYDLAAKEYRPPKDLPELKTYLQAAVEIEHLTIPVYMSGLYSIVPGTNAYACEVIRSVLLEEMLHMTLAGNLLNAVGGTPDMGKLTPGYPARLPFGDASLPPIALQHFSPDALETFLLIERPHSFVPSNPDETGWTSIGQFYDAIRRGIIALEETARSAEQTIFTGDPAEQVGPEDFYNSGGETFRITDLKSALLAIEVISEQGEGAQDSIWDSDDKIFGEQRQVAHYFRFNEIVTGRSYGPHDLPRTQPSGPLIDVTWQDAYPIDPEAKSAHFAPYPEIHRAVEDFNDTYARLLVLFERVFDGKPREMEKAVPLMLELRDLAQRIYRNPHPDTADKPGLHASPTFELDDSRLRRAREHLTELLAAPPEIPAQTATGPVGAQKEEQHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBQ9</accession>
    <name>A0A0F7NBQ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_29045</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_29045"/>
    <dbReference type="EnsemblBacteria" id="AKH85621">
        <property type="protein sequence ID" value="AKH85621"/>
        <property type="gene ID" value="AA958_29045"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_29045"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6120"/>
    <dbReference type="OrthoDB" id="403436at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH85621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="144" mass="15788" checksum="0452392C1882409B" modified="2015-07-22" version="1">MAGRLRRSCPWHEAEITVVDRDDDHVHRSGLLFVPSGRTAARISVHPRAQYLPPGIGLRCPEATYVDPTARTVYLADGTLLPYVLLVVADGAPPPARLPGEAHRVRGQGRGLPVRALAEFSGTPVKEFRLIVPRTRRRTSTLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBV6</accession>
    <name>A0A0F7NBV6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Multidrug ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_24975</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018170.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_24975"/>
    <dbReference type="EnsemblBacteria" id="AKH84919">
        <property type="protein sequence ID" value="AKH84919"/>
        <property type="gene ID" value="AA958_24975"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_24975"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5263"/>
    <dbReference type="OrthoDB" id="1833499at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="2"/>
            <end position="227"/>
        </location>
    </feature>
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        <location>
            <begin position="299"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="313"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH84919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="336" mass="35950" checksum="3823A8BE8E7721B9" modified="2015-07-22" version="1">MIELEGLTKRYGDKLAVDHLTFQVRPGMITGFLGPNGAGKSTTMRMMLDLDNPTSGSVRIDGKHYRELQEPLKYIGALLDAKNMHGGRSAYNNLLCLAQSNRIPAARVSEVLETVGLTAVAKKKSKGFSLGMGQRLGIAYALLGDPEILMFDEPVNGLDPEGIHWIRNLMKSLAAQGRTVFVSSHLMSEMALTADHLVVIGQGKLLADTSMAGFIRENSRSYVRVRTPQPEQFKDAASAAGMTVSLREDGAFEVEGADMAEPVGELAAQHRVTLHELSPQQASLEEAFMQMTAQAVEYHAHDLSDPDAAAAAGAAPPGPPAPNAPPAPGPQWGKGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NC73</accession>
    <name>A0A0F7NC73_9ACTN</name>
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        <submittedName>
            <fullName evidence="5">Glutamate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_25600</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
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    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glutamate synthase family.</text>
    </comment>
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        <property type="protein sequence ID" value="AKH85034.1"/>
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_25600"/>
    <dbReference type="EnsemblBacteria" id="AKH85034">
        <property type="protein sequence ID" value="AKH85034"/>
        <property type="gene ID" value="AA958_25600"/>
    </dbReference>
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    <dbReference type="PATRIC" id="fig|444103.5.peg.5397"/>
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    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="F:glutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:glutamate biosynthetic process"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Aldolase_TIM"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR002932">
        <property type="entry name" value="Glu_synthdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027283">
        <property type="entry name" value="YerD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01645">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006429">
        <property type="entry name" value="GOGAT_lg_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500060">
        <property type="entry name" value="UCP500060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519483" evidence="3">
        <location>
            <begin position="27"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="Glu_synthase" evidence="4">
        <location>
            <begin position="155"/>
            <end position="470"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00009716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR006429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH85034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="527" mass="56581" checksum="A85FA74FCC13BF43" modified="2015-07-22" version="1">MKRNSFFAAVVVAAIGCTLAATLVSGAWWPAAGVFLALAALGVWDVLQRHHSVLRNYPLVGHLRFLLERLRPEMQQYFIERNFDGRPFDRNVRSIVYERAKGTDAEEPFGTELDVEAPGHRFLVHSIAPVAMPTTPPRVRVGGPDCTRPYDMALLNVSAMSFGALSSHAILALNGGAARGGFAHDTGEGGISEFHLRPGGDLVWEIGTGYFGCRTPDGDFDARQFAGKAADDRVRCVSLKLSQGAKPGIGGLLPGAKVDARIARARGVPQGETVVSPPYHRVFSTPRELVRFVARMRELAGGKPAGIKLCVGSRVQLLAVCKAMLAEGTAPDFILVDGSEGGTGAGPLEFADNIGAPLTQGLAAVHGALIGTGLRDRIRIGAAGKVATGSDIVKRLIQGADYTNSARAMMFALGCLQTQRCHTNTCPVGVTTQDPRRVHALDVADKTVRVERFQRATVQSALEIMSAMGVEDPAQLRRHQLRVRIEPRAVRRDDRPLPPPAPGQLLAEPPRAWAADWAAADPDRFTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCF2</accession>
    <name>A0A0F7NCF2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_21685</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_21685"/>
    <dbReference type="EnsemblBacteria" id="AKH84377">
        <property type="protein sequence ID" value="AKH84377"/>
        <property type="gene ID" value="AA958_21685"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_21685"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4568"/>
    <dbReference type="OrthoDB" id="489714at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_5" evidence="2">
        <location>
            <begin position="112"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH84377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="394" mass="41173" checksum="A17D0D4E6F80B269" modified="2015-07-22" version="1">MTTTTGAGAAIGGSGEAGRAPESAGSAGAGGSAAADAALRPHAEDAFAHELAALAAADDRPRPPRWRLSPWAVSTYLLGGTLPDGTAVTPKYVGPRRIVEVAVATLATDRALLLLGVPGTAKTWVSEHLAAAVSGDSTLLVQGTAGTPEEAIRYGWNYAQLLAAGPSREALVPSPVMRAMAEGMTARVEELTRIPADVQDSLITILSEKTLPIAELGEEVQAVRGFNVIATANDRDRGINELSSALRRRFNTVVLPLPASPEDEVGIVTQRVAQIGASLQLPPVPEAVDEIRRVVTVFRELRDGETSDGRTKVKSPSGTLSTAEAISVVTGGLALAAHFGDGVLRASDVAVGIQSAVVRDPAADGVVWQEYLETVVREREGWKDLYRACRELTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCI0</accession>
    <name>A0A0F7NCI0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_32690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86190">
        <property type="protein sequence ID" value="AKH86190"/>
        <property type="gene ID" value="AA958_32690"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_32690"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6907"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519295" evidence="2">
        <location>
            <begin position="21"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH86190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="185" mass="18888" checksum="80194CA46426D2D2" modified="2015-07-22" version="1">MLAASRRAASRLFGPCTAITARRLCATLVRTPTVTPCRGTSVRSEKPGKVFMLSARVVSASAVIRLPESAAVPGGLNATCPSDAPEASRNRSTPPASASLASYAAGSCGDGNHTASAGIERPWPAAALSGPAISSAAKRWQLKCAAWSTSRKPPPGAGSTYSSIIAIATWRRSGPRAAVSRASAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCK2</accession>
    <name>A0A0F7NCK2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AA958_32850</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019442.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86215">
        <property type="protein sequence ID" value="AKH86215"/>
        <property type="gene ID" value="AA958_32850"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_32850"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6940"/>
    <dbReference type="OrthoDB" id="1857862at2"/>
    <dbReference type="Proteomes" id="UP000034283">
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        <property type="entry name" value="RNA_pol_sigma-B/F/G"/>
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        <property type="entry name" value="sigma70-ECF"/>
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        <location>
            <begin position="43"/>
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        </location>
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        <location>
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        </location>
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        <location>
            <begin position="210"/>
            <end position="256"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
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        </source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH86215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="267" mass="30113" checksum="B923D058447E91F6" modified="2015-07-22" version="1">MAHVRARSGKHPHDDAPDTSAQFRRLSGMPEGPEKKALRQDVVRAWMPMAQRLARQFRNRGEALEDLEQVAHLGLVKAVRRYDPARGNAFESYAVPTIVGELKRHFRDHMWGVHVPRRVQELRNRVRSASMALATTADDRFPPAADIAEEAGLTEDEVRTGLQALESYATLSLDATLTDAEDGYSLADTVATTEPGFDRAVDRAAARPHLSRLPEREREILYLRFFRDMTQSSIAEHLGISQMHVSRLISNTCERVYARVEMDRTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCW3</accession>
    <name>A0A0F7NCW3_9ACTN</name>
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        <submittedName>
            <fullName evidence="5">IucA/IucC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_26630</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
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        <text evidence="1">Belongs to the IucA/IucC family.</text>
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    </dbReference>
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        <property type="project" value="UniProt"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="IucA_IucC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IucA_IucC" evidence="3">
        <location>
            <begin position="142"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="FhuF" evidence="4">
        <location>
            <begin position="417"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06276"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AKH85213.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="599" mass="66107" checksum="16D0C5B6FC0CAF61" modified="2015-07-22" version="1">MSDAANTTRRTDWDLAARRLLAKMLGEFAYEGIVTPEPDPGPGPRPGPAGHGRYSYRLPVTDEVTYRFTARRGPYGHWRVDPGSLTPDGDPLRFLAQAHDGLLRLAGDTTGHLIRELTATLAADVRLACGAPSAARLADLGYAELEGHQTGHPWLVANKGRIGFSAADAAAYAPEARLPRRLPWLAVHRSLAEYRGVPALARPGDLYAQELDDATRAGFAAAVAAAGRDPDAYLWLPVHPWQWDETVATLYAPQVAAGLVIPLPPDADPADMWLPQQSVRTFLNLSRPQARSVKLPLSVLNTLVWRGLPTERTLAAPMVTRWVHGMRDADPFLAEETRVLLLGETASVTVRHPLYDSLPGVPYQYRELLGCIWREPVGPLLDPGERARTLAALLWTDAGGRSLTAELVRRSGLAPRAWLARLFGALLPPLLHFLYRYGTVFSPHGENAVVVFDGADVPVRLAVKDFVDDVNVSSKPLPEHAGMPGDVRRTLLTEPPEFLPQFIHSGLFVGVFRFLAPLCADELGVPEAEFFGLVRAEILRYQRRFPELKERFALFDLLAPRIDRLCLNRNRLYLDGYRDRARRPHAAVDGTVPNPLHST</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7ND61</accession>
    <name>A0A0F7ND61_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_27305</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018558.1">
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_27305"/>
    <dbReference type="EnsemblBacteria" id="AKH85323">
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        <property type="gene ID" value="AA958_27305"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_27305"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5754"/>
    <dbReference type="OrthoDB" id="1911275at2"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
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        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="14"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH85323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="236" mass="25686" checksum="C569DE67C967E5A5" modified="2015-07-22" version="1">MAEAKRGKLISVQKHLRDQVANALRAALIAGELRPGAIYSAPALATEFGVSATPVREAMLDLAREGLVEAVRNKGFRVTEMTEGDLDNYTEIRELIEVPTVGRVTEVATEEQLEALRPLAEDIVKATRDHDLIGYLEADRRFHLSLLALAGNDHLVTVVAELRNRSRLYGLTDLDRAGVLVDSAQEHLTLLDLMIAGNATAAQELMASHLGHIRTLWAAGRRSAAKRASALRLGEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7ND92</accession>
    <name>A0A0F7ND92_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Nucleotide pyrophosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_27660</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018618.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_27660"/>
    <dbReference type="EnsemblBacteria" id="AKH85384">
        <property type="protein sequence ID" value="AKH85384"/>
        <property type="gene ID" value="AA958_27660"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_27660"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5827"/>
    <dbReference type="OrthoDB" id="1760741at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047429">
        <property type="term" value="F:nucleoside-triphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009143">
        <property type="term" value="P:nucleoside triphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11537">
        <property type="entry name" value="NTP-PPase_RS21-C6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025984">
        <property type="entry name" value="DCTPP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12643">
        <property type="entry name" value="MazG-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029826">
        <property type="entry name" value="UCP029826_pph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH85384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="115" mass="12673" checksum="269E753D4E6D8525" modified="2015-07-22" version="1">MSDDVQALQKRLVAFAAARDWEQYHTPKNLAAALSVEAAELVEVFQWLTPEESARIMADPDAAHRVADEVADVLSYLLQFCSVVGVDPLAALAAKIERNEERFPAPRDPEPGEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDP2</accession>
    <name>A0A0F7NDP2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_28650</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018788.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_28650"/>
    <dbReference type="EnsemblBacteria" id="AKH85554">
        <property type="protein sequence ID" value="AKH85554"/>
        <property type="gene ID" value="AA958_28650"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_28650"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6036"/>
    <dbReference type="OrthoDB" id="1437290at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="17"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH85554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="265" mass="28732" checksum="D84840CEC9462935" modified="2015-07-22" version="1">MSQPAKPSRSNSSTQRLKMRRDIAAAAMELFATKGYEATTVDEIAAAAGVARRTFFRHFRSKEEAIFPDHDDTLERVKAVLDAAPPHEYPLDTVCRGIREVMRMYAAQPAVSVERYRLTREVPTLREREIASVSRYERLFTRYLLGHFDEGAHQDGDDGPLLAEVAASAVVTAHNHVLRRWLRAGAEGDVEGQLDRAFAVVRARFTGVGQPHGPATLGSAEAGAAGAPAVVAGGGEGSDVLVAVARTDAPLSEVMRTIEKALKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDS1</accession>
    <name>A0A0F7NDS1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_33710</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019588.1">
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86366">
        <property type="protein sequence ID" value="AKH86366"/>
        <property type="gene ID" value="AA958_33710"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_33710"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.7117"/>
    <dbReference type="OrthoDB" id="1757088at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="3">
        <location>
            <begin position="155"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH86366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="252" mass="26930" checksum="8D7D00C06FE24A6F" modified="2015-07-22" version="1">MPDIRHTPEAPTRATTLAAGARIDAHRHDDHQLVYAGAGVLAVTTDAGTWFAPGTRALWVPAGCVHAHRAYGHLDLHLVGVPAATDPLGLDAPGVLAVSPLLRELILACTREPHDGTPERQRLHTVLLDRLRAAAAAGAAGQPVPLPAPADPRLAAVCDLLYADPADQRTLAVLGRAAGAGERTLSRLFRRETGMTFPQWRTQVRLYHALRLLADDVPVTTVAHRCGWSSASAFIDVYRRAYGTTPGSSRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDS2</accession>
    <name>A0A0F7NDS2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_10050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019922.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86655">
        <property type="protein sequence ID" value="AKH86655"/>
        <property type="gene ID" value="AA958_10050"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_10050"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2116"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="156" mass="17124" checksum="7F6B69C609E614F4" modified="2015-07-22" version="1">MDLCAYSLTDGSPGRPFLRVSDETGSANNFEVHDVAAAAFMLQQMAGAVRNLAGFLEMLSARQEAEEAQWQAVRLDGEVRQAEQQRARAEAGLRQAQEYIAVLEREMEAASAARDTANWQVEAARERLADAERTARESRRVAEAAAARSARLEGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDS3</accession>
    <name>A0A0F7NDS3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycosyl hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_28870</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018827.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_28870"/>
    <dbReference type="EnsemblBacteria" id="AKH85594">
        <property type="protein sequence ID" value="AKH85594"/>
        <property type="gene ID" value="AA958_28870"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_28870"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6083"/>
    <dbReference type="OrthoDB" id="1046649at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006584">
        <property type="entry name" value="Cellulose-bd_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005084">
        <property type="entry name" value="CMB_fam6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012938">
        <property type="entry name" value="Glc/Sorbosone_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022409">
        <property type="entry name" value="PKD/Chitinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000601">
        <property type="entry name" value="PKD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035986">
        <property type="entry name" value="PKD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011041">
        <property type="entry name" value="Quinoprot_gluc/sorb_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03422">
        <property type="entry name" value="CBM_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07995">
        <property type="entry name" value="GSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00606">
        <property type="entry name" value="CBD_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00089">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49299">
        <property type="entry name" value="SSF49299"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50952">
        <property type="entry name" value="SSF50952"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51175">
        <property type="entry name" value="CBM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50093">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519433" evidence="3">
        <location>
            <begin position="33"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="4">
        <location>
            <begin position="498"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="domain" description="CBM6" evidence="5">
        <location>
            <begin position="691"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="694"/>
            <end position="714"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH85594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="819" mass="85329" checksum="F3F9101603A3BF8A" modified="2015-07-22" version="1">MHTRRIRRTLTRTVTALLAAPALVLGTSATGAAHPGEDHEAPAAAEFQQVTLAKGEPEMGEPMTMAVLPDRSVLHTSRDGTVRLTDAAGTTKIAGKLAVYNHDEEGLQGVGVDPGFAQNRFVYLYYAPPLDTPAGDAPSDGSAADFAPFDGVNRLSRFVLKGDGTLDTGSEKAVLDVPASRGLCCHTGGDIDFDAQGNLYLSTGDDTNPFASDGYTPIDERATRNPAFDAQRSAGNTNDLRGKVLRIKVNADGSYDIPDGNLFAPGTEKTRPEIYAMGFRNPFRLSVDKPTGTVYVGDYGPDAGTAGDTRGPAGQVEFARITEAGNFGWPYCTGDNDAYKDYDFGSGASGAAFDCGAPVNDSPHNTGLTELPPAQPAWIPYDGNSVPEFGNGSESPMGGPVYRRDEVDDGSAVAFPAEYEGNFFAGEFGRKWIKRIEQGGDGTVAAINDFPWSGTQVMDMDFGPDGALYVLDYGTGYFGGDENSALYRIENMTGGASPVAEASADKTSGQAPLAVQFSSAGTTDPDSTELTYSWDFGDGATSDQADPAHTYAENGTYNVTLTATDPDGLTGSANVQITVGNTAPTVTLDLPRDGQSFSFGDDVPFEVTVADPEDESVDCGKVRVAYILGHDSHGHEMTSANGCSGTLKTAADGEHDPNANLYGGLTATYTDGGGGGQGALTGTDQAKLQPKHRQAEHYDGSQGVAPQSKPAANGGKTVGDIHAGDWIAFEPWVLSDVTGLTARISSAGAGGTLEVRAGAPDGTLLGSTEVPVTGGWDTFQDVTATLSGAPDGTTKLYLVFAGSSTDPLFDVDDFTLTTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NE26</accession>
    <name>A0A0F7NE26_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_29710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018942.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_29710"/>
    <dbReference type="EnsemblBacteria" id="AKH85714">
        <property type="protein sequence ID" value="AKH85714"/>
        <property type="gene ID" value="AA958_29710"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_29710"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6272"/>
    <dbReference type="OrthoDB" id="194265at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012878">
        <property type="entry name" value="Glyco_hydro_127"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07944">
        <property type="entry name" value="Glyco_hydro_127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="389"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="603"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="608"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="662" mass="71310" checksum="6FFB10535D648C2D" modified="2015-07-22" version="1">MKENAQVARVPGGTDPRGGRPVVPSRGERRPLGLAEVTPTGGGFWQDLQRTNAAATLAHCERWMERLGWLANFDRVADGTTGPDRAGWSFADSEVYKLVEALAWEYGSTGDPVHGAAVRRLTARIARAQDPDGYLNTCYGHPGRPPRYSDLEFGHELYCTGHLLQAAVARLRTTGEDELVAVARRAADHVCATFGPDGLKGVCGHPGIETALTELGRALGEPAYTDQAQLFLDRRGHRTLAVPFGIGGAGYFQDDVPVREAGGWRGHAVRQLYLAAGAVDVAVERDDRKLIAAVERQWAHAVARRTHLTGGMGSRHRDEGFGDDWELAPDRAYCETCAGVASVMVSWRLHLATGDMRYADLMERTFFNVVATSPSADGRAFFYANPLQQRTRGEGPGRSADGEVSPRAEGGTRAAWFDVSCCPTNVARTLASWHTYLATAGPRELTLLQYASGRIAAELGDGRTVAVEVETAYPVAGLVTVRVVDAPAGAMALRLRVPGWARGAVLHEGGRQRPAAPGPVVVDRVLVPGEEIRLNLPVTSRFTWPDRRIDALRGSVAVERGPLVYCAESTDLPDGLSLDDVLLDTTAPPVERDGTVLARAVPAPRHAPEAEPAWPYAPEPGPAASSGPARELPLTPYHRWAERGPATMRVWLPAAPRDPGPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NE38</accession>
    <name>A0A0F7NE38_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chitin-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_25130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018198.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_25130"/>
    <dbReference type="EnsemblBacteria" id="AKH84947">
        <property type="protein sequence ID" value="AKH84947"/>
        <property type="gene ID" value="AA958_25130"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_25130"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5296"/>
    <dbReference type="OrthoDB" id="1005693at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004302">
        <property type="entry name" value="Cellulose/chitin-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03067">
        <property type="entry name" value="LPMO_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519442" evidence="1">
        <location>
            <begin position="41"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-4" evidence="2">
        <location>
            <begin position="41"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH84947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="182" mass="19139" checksum="9C3878C49A73873B" modified="2015-07-22" version="1">MHRSTKPARKRAAGATRAAFVGAGVAPLLLLALPTQQANAHGWITNPPSRQEQCAKGVVECGAIKYEPQSVEGPKGLTSCSGGNQGFAELDDDGKGWKVTDVGSTTTFNWKITARHSTSTWQYFVGGQKVAEFDDGGAQPPAEFSHSVNFGGITGKQKVLAVWNVADTGNAFYACIDVNIGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NEM0</accession>
    <name>A0A0F7NEM0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_19435</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020249.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_19435"/>
    <dbReference type="EnsemblBacteria" id="AKH86905">
        <property type="protein sequence ID" value="AKH86905"/>
        <property type="gene ID" value="AA958_19435"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_19435"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4086"/>
    <dbReference type="OrthoDB" id="1438064at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH86905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="175" mass="19266" checksum="DEB35D24E2D932D2" modified="2015-07-22" version="1">MVGAISEIPPLTTEEQLTTASTSVDDLNGLEHKSHTTVAMDFGRITLTTPQHLVIYLFGTPGQERFLYMWDDLAHGAVGAIVLVDTRRLHVSFTAVSYFERTTLPFVVAVNEFDTPERHHYSPDEIRLALEIPQAVPVVTCDARDLHSAVAVLRTLVEHALTTARSHPTAVGARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NF43</accession>
    <name>A0A0F7NF43_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-hydroxyacyl-CoA dehydrogenase</fullName>
            <ecNumber evidence="2">1.1.1.35</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AA958_32065</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:22432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57318"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="1.1.1.35"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.35" evidence="2"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019317.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_32065"/>
    <dbReference type="EnsemblBacteria" id="AKH86089">
        <property type="protein sequence ID" value="AKH86089"/>
        <property type="gene ID" value="AA958_32065"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_32065"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6770"/>
    <dbReference type="OrthoDB" id="977512at2"/>
    <dbReference type="UniPathway" id="UPA00659"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003857">
        <property type="term" value="F:3-hydroxyacyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3HCDH_N" evidence="9">
        <location>
            <begin position="322"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="3HCDH" evidence="8">
        <location>
            <begin position="503"/>
            <end position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AKH86089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="725" mass="77785" checksum="4A74964F89ADE9AC" modified="2015-07-22" version="1">MSHTNTIRWEQDDTGVVTLVLDDPNQSANTMNADFIQSLTVVADRLEAERDGVRGVVFASAKKTFFAGGDLHDLIRIDREHAREAFDAGMAVKHALRRIETLGKPVVAALNGAALGGGYEIALACHHRVALDAPGSKIGLPEVTLGLLPAGGGVTRTVRLMGITDALLKVLLQGTQYRPRRALENGLVHEVVETEEELRAAARAFVDAHPESRQPWDEPGYRIPGGTPQNPKFAANLPAFPANLKKQLGGAPFPAPRSIMAAAVEGSQVDFETAQVIEARYFVDLAVGQTAKNMIQAFFFDLQAVNAGRSRPSGVPERRVAKVAVLGAGMMGAGIAYACARAGIEVVLKDVSPEAAEKGKAYSAGLLDKQLAKGRTTQEKRDALLARITPAADPAELAGCDAVIEAVFEDPALKHKVFQEIQDVVAPDALLCSNTSTLPITLLAEGVARPQDFVGLHFFSPVDKMPLVEIIKGERTGDEALARAFDLVRQLAKTPIVVNDSRGFFTSRVIGHFINEGVAMVGEGIEPATVEQAAAQAGYPAKVLSLLDELTLTLPRKIRNETRAAVEAAGGSYPVHPAEAVIDRMVDEFGRTGRAGGAGFYDYEDGKRTRLWPGLREHFTKADREPPPLRDLQERMLFAEALDTVRLVEEGVLTSVADANIGSVFGIGFPAWTGGVLQYINGYDGGLSGFVARARELAEAYGERFEPPALLLAKAERGEPFMDAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NF88</accession>
    <name>A0A0F7NF88_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_30285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_30285"/>
    <dbReference type="EnsemblBacteria" id="AKH87140">
        <property type="protein sequence ID" value="AKH87140"/>
        <property type="gene ID" value="AA958_30285"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_30285"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6398"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="1"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH87140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="502" mass="52895" checksum="0EE382B9DE3721E1" modified="2015-07-22" version="1">MLAGELRLGGARVVVLERLARPTGQSRGLGFTARAMETFDQRGLLPRFGQGETLEISPMGHFGGVQFDYTVLADGHFGARGIPQNQTEAVLEEWAAELGADIRRGAELVEIADGFLDGDHVEVAVATAGGVERLRAAYLVGCDGGQSRTRKLAGFDFPGLPATRTMFLADVLGCNLKPRFLGERLPNGMVMAAPLREGVDRIIVCPHGAPARDRDDDVTFAEVARAWQHITGEDISGGSADWVSSFSDATRQVREYRRGRVLLAGDAAHIHLPAGGQGLSTGVQDAANLGWKLAAEIRGTAPAGLLDSYHAERHAVGRRLLMNTRAQGIVFLGGEQSDPLRELFAELIGGYDDVKRHLAGIVSHLDIRYDLTAADGADGTEGAGGPDSAAAPVHPLLGRRIGKRPLTGAGGDTDTVRLLRAGRGVLLDLADDAALRTAAAPWADRVDVVTAVAKPPEDGDDLLAGAGAVLVRPDGYVAWVGADTEKDPAAALGRWFGAGRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFA4</accession>
    <name>A0A0F7NFA4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_32425</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019376.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_32425"/>
    <dbReference type="EnsemblBacteria" id="AKH86149">
        <property type="protein sequence ID" value="AKH86149"/>
        <property type="gene ID" value="AA958_32425"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_32425"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6844"/>
    <dbReference type="OrthoDB" id="1293876at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519405" evidence="2">
        <location>
            <begin position="28"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH86149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="369" mass="38421" checksum="A3B18C22E4D03B1A" modified="2015-07-22" version="1">MTLRGTLRHRAATCLGVCVLAAGPVYATDTAAGADTGTDREPVARHLPGWELKETGSKARLRGLSAVSRDTAWVSGSGGTVLRTTDGGRSWRDVSPPGTEALEFRDIEALGRRSAVALSIGPGEDSRIYRTDDAGATWTETFRNDHPGAFYDCVTFFAGGREGLALSDPVDGRFRILSTSDGGRSWKVLPDDGMPPAQPGDAAFAASGQCLVSAGRSDAWFATGGGATARVLHSADRGRTWTEAESGIPAGDPARGVFALAFRDARHGLAVGGDFQPGNPSPDAAARTGDGGASWTDARKPPPEYRSGVAWLPHSRGAALAVGPTGSDVTFDAGRTWHGFDSGSYDTVDCSADLGCWAAGEQGRVARLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFD6</accession>
    <name>A0A0F7NFD6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_32320</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH87190">
        <property type="protein sequence ID" value="AKH87190"/>
        <property type="gene ID" value="AA958_32320"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_32320"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6823"/>
    <dbReference type="OrthoDB" id="2049098at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="2">
        <location>
            <begin position="14"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH87190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="182" mass="19810" checksum="39DFF866C70C2483" modified="2015-07-22" version="1">MAREVAEITPARALDLAAGEGRNALWLAARGWRVTAVDFSQVALERGRRRAAELPQEAAERIRWVRADLLEYAPEEGSYELVVVAYLHLPGAQRRRVLRRAAAALAGGGELLVVGHDSANLTEGTGGPQEPAVLFTAEDVLSDLADDPLRTVRAERVRRPVAQEEGPPKEAIDALARLRRAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFJ8</accession>
    <name>A0A0F7NFJ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phytoene synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_32200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Carotenoid biosynthesis; phytoene biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019341.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_32200"/>
    <dbReference type="EnsemblBacteria" id="AKH86113">
        <property type="protein sequence ID" value="AKH86113"/>
        <property type="gene ID" value="AA958_32200"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_32200"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6799"/>
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        <property type="term" value="P:carotenoid biosynthetic process"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="CDD" id="cd00683">
        <property type="entry name" value="Trans_IPPS_HH"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
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        <property type="entry name" value="SQ_synth_HpnD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002060">
        <property type="entry name" value="Squ/phyt_synthse"/>
    </dbReference>
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        <property type="entry name" value="Squalene/phytoene_synthase_CS"/>
    </dbReference>
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        <property type="entry name" value="Trans_IPPS_bact-type"/>
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        <property type="entry name" value="Trans_IPPS_HH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00494">
        <property type="entry name" value="SQS_PSY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01212">
        <property type="entry name" value="Phytoene_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01018">
        <property type="entry name" value="Squalene/Phytoene_Synthase_Lik"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS01044">
        <property type="entry name" value="SQUALEN_PHYTOEN_SYN_1"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS01045">
        <property type="entry name" value="SQUALEN_PHYTOEN_SYN_2"/>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH86113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="311" mass="33774" checksum="EE44228DF6C80ACF" modified="2015-07-22" version="1">MTTPSRAAYASAQVLTAYRYCEAVTGRQARNFAYGIRLLPYDKRLAMSALYAFSRRVDDIGDGELPPEAKRARLEETRGQLDRIRAGQVAEDDTDPVAVALAHAARRFPIPLGGLDELIDGVLADVRGQEYETWEDLKDYCRCVAGAIGRLSLGVFGTVPGTRHSERAPGHADTLGLALQLTNILRDLREDAAEGRSYLPAVDLAKFGCSAGFHGDTAPAGSDFPGLVQFEVRRARALFADGYRLLPMLDRRSGACVAAMAGIYHRLLERIAAAPEAVLRGRVSLTGREKAYVAVRGLAGVDARQASRRSR</sequence>
</entry>
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    <accession>A0A0F7NFX4</accession>
    <name>A0A0F7NFX4_9ACTN</name>
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        </submittedName>
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    <gene>
        <name evidence="2" type="ORF">AA958_33840</name>
    </gene>
    <organism evidence="2 3">
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_33840"/>
    <dbReference type="EnsemblBacteria" id="AKH87216">
        <property type="protein sequence ID" value="AKH87216"/>
        <property type="gene ID" value="AA958_33840"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_33840"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.7146"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH87216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="539" mass="58302" checksum="F2E46B14772C2190" modified="2015-07-22" version="1">MAVLDGAGLAHLADGRTAPCPAGSVAELVDWALRAGLGAERLHRHGQDADPLVVLTEAAAERLGLPPRLDNRAFDDGMRLAEDHPVVREILAAGWKLTRRGFGPWPRIYRPAEHGRRRCVQLAVLGWDALEDRAWPGAGQVPPGELARMLGTYAARVLTPRGSTAVTGLELMTALRPPTRPVRDGAAWTPGPVPGSLTAPVDPAPPEAPEEHPVAEGRPAGQELDEEAYDWVRPCGFTDAECALPYVLGLDVNMAFAAAANRLTVGLGAPVHTDGPRFDKKVPGAWYVDLSHVELDPRLPSPFTPSGDRPSGPAWYATPTVAYAVELGHDVAPLEAWLRPEAGAYLDPWYERLRDAYLATMADLGVTKDLTEAGYLAAMAGHKDVDPAAAAVLSAIKATVKGGIGKLRERAQGKARFRTNQRWPALERPTWRPDIRAAVIATARVNMHRKMLKMATHGRYPVAVLSDCVVYPAPTPSPLDLLPRTPDGRPAPGVFRLGVSPGMTKLEGVRDLWWAAEVIEEHYNPARHIKDDPTRDGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-06-17" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFX5</accession>
    <name>A0A0F7NFX5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_32925</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019455.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86228">
        <property type="protein sequence ID" value="AKH86228"/>
        <property type="gene ID" value="AA958_32925"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_32925"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6957"/>
    <dbReference type="OrthoDB" id="1335734at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="5"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="163"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="311" mass="33796" checksum="0DE99B6C70567D0C" modified="2015-07-22" version="1">MRIYRIDHIGQVAPELEPQVALLEGLFGFRSTRSWENPEEGCRGVRLELPGNPGHTWEVLAPAGERSAVQEFLDGQGGRPGLHHVAAEVPDLAAVRAELEALGVKPAAGGDGGWLEASLSPPERGPGVLFRLRGPGGLDLCGDGPAVPVTAEPPDAPSLGIVALDHVCQAFPDRDELARWYERLAGFVQVWRTPGDEHPDMADLVLNIPGSTICWEVIMPRGEDSFIERFWDRNGAAAHHVTFEVADWDRAAAACAYHGVPTFGENEGSTDGAAWRDTFIHPKHTGGVLVQLFWEERPGVWVRSDKIPPVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NGK7</accession>
    <name>A0A0F7NGK7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Succinate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_06230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_06230"/>
    <dbReference type="EnsemblBacteria" id="AKH86574">
        <property type="protein sequence ID" value="AKH86574"/>
        <property type="gene ID" value="AA958_06230"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_06230"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1303"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011138">
        <property type="entry name" value="Cytochrome_b-558"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81343">
        <property type="entry name" value="SSF81343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02046">
        <property type="entry name" value="sdhC_b558_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="219" mass="24379" checksum="9E79B5218A29BF6A" modified="2015-07-22" version="1">MLWRSTVGKKTVLAVTGLIMLAYLVAHLIGNLKIFYGAEEFNDYGHWLRTLGGPVLHYEWALWMIRVVLVVAVVLHGVTAYQLSRRDIAARPVAYVHKRRRAGYATRTMRWGGVILGLFIVWHILDLTTLTVNENAQTGRPYENTVATFSTWYGNVVYITAMLALGLHLRHGFWSAVQTLGVASPARERALKTVTNTLALVLTCGFISLPVAVMTGVVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NGR5</accession>
    <name>A0A0F7NGR5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_01555</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_01555"/>
    <dbReference type="EnsemblBacteria" id="AKH86488">
        <property type="protein sequence ID" value="AKH86488"/>
        <property type="gene ID" value="AA958_01555"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_01555"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.342"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026870">
        <property type="entry name" value="Zinc_ribbon_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13240">
        <property type="entry name" value="zinc_ribbon_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SSF49879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="99"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH86488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="176" mass="18910" checksum="C54C2CEA9D0A79B0" modified="2015-07-22" version="1">MPVCNRCGARNAQASRFCSNCGAPLRAGVAERPSETTTTISISGIEAYEAEVASGGQTLPPLSPEAQAAVDALPPGSALLVVRRGPNSGARFLLDSELTTVGRHPQSDIFLDDVTVSRRHVEFRRTPDGRFSVADVGSLNGTYVNRERIDEFELTSGDEVQIGKFRLVFFASRRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NGR9</accession>
    <name>A0A0F7NGR9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AA958_31085</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019150.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_31085"/>
    <dbReference type="EnsemblBacteria" id="AKH85922">
        <property type="protein sequence ID" value="AKH85922"/>
        <property type="gene ID" value="AA958_31085"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_31085"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6569"/>
    <dbReference type="OrthoDB" id="1552415at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="103"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="237"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="8">
        <location>
            <begin position="28"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH85922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="279" mass="29646" checksum="19E41DD019FB8994" modified="2015-07-22" version="1">MNACVLRAGLRRGAIELRQSFINGAELFSHLFWPLLMLGVLWFLRGREFGSTGFMLGALTLPGILGMNVSFGMVTMSQLLTAEREDGTLLRAKATPHGMGGYLVGKVVSVAGGLLADLALFLVPALFLVGGLHLDPGAWLHLAGIVALGMVATLPAGAVLGSVFGDARAQGLIQLPVLALIGISGIFYPITALPEWLQWTAQVFPLYWLGLGMRAAMLPDAAAAVELGDSWRQAETVGVLGAWAVLGLAVAPVVLRRMARRESGSKVAARRERALQRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NGX0</accession>
    <name>A0A0F7NGX0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Gluconokinase</fullName>
            <ecNumber evidence="4">2.7.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AA958_04520</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + D-gluconate = 6-phospho-D-gluconate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19433"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18391"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate acid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the gluconokinase GntK/GntV family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.12" evidence="4"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019777.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_04520"/>
    <dbReference type="EnsemblBacteria" id="AKH86543">
        <property type="protein sequence ID" value="AKH86543"/>
        <property type="gene ID" value="AA958_04520"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_04520"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.953"/>
    <dbReference type="OrthoDB" id="775108at2"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046316">
        <property type="term" value="F:gluconokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02021">
        <property type="entry name" value="GntK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006001">
        <property type="entry name" value="Therm_gnt_kin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Lactamase_B" evidence="9">
        <location>
            <begin position="180"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AKH86543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="455" mass="47760" checksum="704EA6F565DCDEE1" modified="2015-07-22" version="1">MGVTVPLIVVMGVSGCGKTTVGRELAERLNVPYADGADIGREAGLSPALGEPSDEAVAGWLRRRAASGGVVSRPALRRRDRDRLAAAVPGLYFLHLDGSRHLVGARLAERKELFVPHDVLDAQFAALEPLAPDEHGAAVGIDGTPAQIVDRAVDAARTPYSVQLATGVHAYIQPDGGWCLSNAGFVSDGTTTLLVDTAATEPRAKLLREAVLASGAPDPALVVNTHHHGDHTYGNSVFAPATVVGHAACRQQVLAAGRHLELLWPEVEYGDVRLTAPGMTYTESMTLTAGGTEVRLLHPGPAHTVGDTVVWLPEQRVVFAGDIALCGGTPFVAFGSLGGSLRALEHLRSLGAETVVPGHGPVTDAGVFDAVERYLRYVGELAAQGRAAGRTPLETARAADPEAFAELREPERLVANLHRAYSELAGEPEGRPLDAAAYFADMAALNGGKMMPCHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NH06</accession>
    <name>A0A0F7NH06_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_12560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_12560"/>
    <dbReference type="EnsemblBacteria" id="AKH86719">
        <property type="protein sequence ID" value="AKH86719"/>
        <property type="gene ID" value="AA958_12560"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_12560"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2639"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="287" mass="28116" checksum="B9CB00209306CF5C" modified="2015-07-22" version="1">MAAAALVGGGIAGGYAMWGGDDGDEAGGGGPVVYGPDGEPRSPGPGEGPGGGGPDGGSGGSGGGPGESPGPQDPEGGEQDPRNPDGGQPPMEIPSEDGFATDLASGIKIPVPDGWKGQSGQIGASVSVGEYKCPTSPKDTCVRGGVNSAPALALGIDATSPKSIAEKDIEPNAEASYGDEAYGGITSHDEVESGEVEVAGEEGYLVRWKVVTKEGDDGYVQSLAFPSPANPDTLVLVRAGFDIGDEAPALDELDEITDGIKESEGGAGLPGGGGRPAGFTPAATARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NH91</accession>
    <name>A0A0F7NH91_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Single-stranded DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_16185</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020123.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_16185"/>
    <dbReference type="EnsemblBacteria" id="AKH86819">
        <property type="protein sequence ID" value="AKH86819"/>
        <property type="gene ID" value="AA958_16185"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_16185"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3410"/>
    <dbReference type="OrthoDB" id="1304273at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02414">
        <property type="entry name" value="jag_KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02644">
        <property type="entry name" value="R3H_jag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038008">
        <property type="entry name" value="Jag_KH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039247">
        <property type="entry name" value="KhpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001374">
        <property type="entry name" value="R3H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034079">
        <property type="entry name" value="R3H_KhpB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35800">
        <property type="entry name" value="PTHR35800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01424">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00393">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="SSF82708"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS51061">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0133">Cell shape</keyword>
    <keyword evidence="2" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="R3H" evidence="4">
        <location>
            <begin position="92"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="136"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH86819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="156" mass="17287" checksum="CBBA0D6A3C66B6BE" modified="2015-07-22" version="1">MTRLEQEGEIAADYLEELLDIADLDGDIDMDVEGGRASVSIIGEGSSDRHLQKLVGREGEVLEALQELTRLAVHRETGDRSRLMLDIAGFRARKRAELTELGTEAVERVKESGEPEKLRPMSPFERKVVHDAVKAAGLRSESEGEEPERRVVVLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NHD0</accession>
    <name>A0A0F7NHD0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Enoyl-CoA hydratase</fullName>
            <ecNumber evidence="3">4.2.1.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_32390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.17" evidence="3"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019369.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_32390"/>
    <dbReference type="EnsemblBacteria" id="AKH86142">
        <property type="protein sequence ID" value="AKH86142"/>
        <property type="gene ID" value="AA958_32390"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_32390"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6837"/>
    <dbReference type="OrthoDB" id="1498685at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH86142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="253" mass="26018" checksum="DE7C20D1DCFD7F3E" modified="2015-07-22" version="1">MSGHVRIERTGHVTTVVLARPGVRNAVDGPTAAELAAAFRDFDADPGARAAVLWGEGGTFCAGADLKAVGSPSGNRVAPDGDGPMGPTRMRLTKPVIAAVSGHAVAGGLELALWCDLRVAEEDAVFGVFCRRWGVPLIDGGTVRLPRLVGTGRALDLILTGRPVPAPEAYEMGLANRLVPPGQARAAAEELAAEIARFPQTCLRADRASVLEQHGLPEAEAMAAELRHGTAALGEAAAGAGRFAAGEGRHGAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NHL5</accession>
    <name>A0A0F7NHL5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_32985</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019464.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86237">
        <property type="protein sequence ID" value="AKH86237"/>
        <property type="gene ID" value="AA958_32985"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_32985"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6969"/>
    <dbReference type="OrthoDB" id="1452500at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="27"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="150"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="227"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="263"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="293"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="317"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="351"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="379"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="26"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH86237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="405" mass="41335" checksum="E94FA2DC9908A7EA" modified="2015-07-22" version="1">MTAAPRGLPDAAEQRFRDALRGLPGRVWIVSLGILVNRVGNFLPVFLVLYLTGRGHSAGAAGLVLGVSGLGNVLGNTLGGYLADTLGRRWTIVLSGVTTAGLTAAVPYLGPLSAIVAVVGLIGVTSHVYRPAAAAALLDSVTTNRQRLAAFGVFRAAMNTGAALGGVAGGVLAGVSYTQLFLANAAASLLFGVVAAVLLRDAPRPRAAEEEQAERAAGYRRALADRLLLRFLLMTAVAEFVYIQSTVGLPLHVTDAGLDARDFGLLIGLNGLLVLALELPATGAVARYRPEHVLGAGNLLVGAGLALTGLMTDMTLLAATVVVWTCGEMITSSVSYAYLGSLTPPHLTGRYQGLHGAAYTVGTGAGPLLGGAAYAVGPWALWSLVAAAGVLSAYLCLPPRPAPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NI15</accession>
    <name>A0A0F7NI15_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_33940</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019629.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86407">
        <property type="protein sequence ID" value="AKH86407"/>
        <property type="gene ID" value="AA958_33940"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_33940"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.7167"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002520110" evidence="2">
        <location>
            <begin position="34"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH86407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="128" mass="12650" checksum="5E5FE929C17A117C" modified="2015-07-22" version="1">MTTPHRRRPRRLILAATAAGVLTVGGLGALAHATTGAEKPAGGSGPQESATPSEVPGEPTPVPSESGPPSEPTAVPSAPGTPSEPQDEPTPVPSVPGTPGEEPGEPTPVPEETGTPTPLAPGEPSPQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NIU6</accession>
    <name>A0A0F7NIU6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Uma2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_13200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86732">
        <property type="protein sequence ID" value="AKH86732"/>
        <property type="gene ID" value="AA958_13200"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_13200"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2778"/>
    <dbReference type="OrthoDB" id="2040599at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd06260">
        <property type="entry name" value="DUF820"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1570.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012296">
        <property type="entry name" value="Nuclease_put_TT1808"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008538">
        <property type="entry name" value="Uma2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05685">
        <property type="entry name" value="Uma2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uma2" evidence="1">
        <location>
            <begin position="15"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="186" mass="21061" checksum="C73F3B2CF8CCDD57" modified="2015-07-22" version="1">MADESDELTLDKLFERVERMPVPEGYKVEIVEGAVYMSPQRDTHWDTIYDILDQLRARYPRRRLKSDVRIDYPGDLNGFASDVIALTTGAAKDDKGRWRPQDVELVGEVISKSTASNDYGPKKAVYATAEVPVYLIVDPYTGKCHLHLMPKDGEYRVETTLDFGMDIDLTETPVGLKLTTGDFPRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NJW8</accession>
    <name>A0A0F7NJW8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_28000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020472.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_28000"/>
    <dbReference type="EnsemblBacteria" id="AKH87077">
        <property type="protein sequence ID" value="AKH87077"/>
        <property type="gene ID" value="AA958_28000"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_28000"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5901"/>
    <dbReference type="OrthoDB" id="404877at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH87077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="405" mass="42154" checksum="56C42995F1BDCF48" modified="2015-07-22" version="1">MAGLTAEEDAAAPPPAGVGPGPARTALVAALGELLGTAPPPRREPVGAELFETLLRAGDRAVETGGERELLLAVALADTGVSLRAKSRAAWRLRARALDALGHAAAATEAYERTLALGSTHPETPVLLSMAREKRTCLATAVGLFPADTAGGRETGAGQETGGPEAGAASAAAGPAFASAVGAEAMPGVVREAFTAYVTEQMGRYGAGDARVRELAGAYGTYCRILDQGRMADPLLAGARPVSVADFRGLVAGKTACVVVGPGRFEEAGDYELVVRCDDFRGGERADVHAVADPASASWHRPAGVRLLFADPGETWRETVRRAVPGAQDGLGDASLRRPLQDPALLGDGGWGPETSAAFTVLRLLDHLDVSPRLDVHGAGRLRPEERRWITSRAKDRTKTRTALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NK32</accession>
    <name>A0A0F7NK32_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_30725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020578.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_30725"/>
    <dbReference type="EnsemblBacteria" id="AKH87152">
        <property type="protein sequence ID" value="AKH87152"/>
        <property type="gene ID" value="AA958_30725"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_30725"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6494"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="8"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH87152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="380" mass="40320" checksum="60689915EDF0AE6C" modified="2015-07-22" version="1">MLSVLAACGDGDDDGGDDGKNSASPAAEAGGATDLSKECPETIVVQTAWWPDITSAGAMYQLLGDDMDVDANAKKVTAPLVASGGKDTGVKLELRSGGPAIGFNPTSSQMYTDDSIHLGIPQGFDEAIQNSGRQPTLAVMSLLAKNPQVIMWDPEKHPDVKSIEDIGRTDTTVVYVPTPYMDYLTSKGILKKDQVDSSGDGSPARFVAAGGTIATSGYATEDPYIYEEELPDWGKPVASQLAYEYYPNPGPSPVIRPADKAELAPCLKKLVPVIQQGAVDLMENPDPVIDKVIELRDTFKADQPFSKGVGKYSVEQMRALDLVADPGKPVGEFDTGRVQELIDLAGPVFEAQKKPIKDGLAPGDLVTNEFIDTSITLGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NK52</accession>
    <name>A0A0F7NK52_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Beta-glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_31710</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_31710"/>
    <dbReference type="EnsemblBacteria" id="AKH87177">
        <property type="protein sequence ID" value="AKH87177"/>
        <property type="gene ID" value="AA958_31710"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_31710"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6696"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="SSF52279"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fn3_like" evidence="3">
        <location>
            <begin position="691"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="787"/>
            <end position="808"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH87177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="808" mass="83923" checksum="DE4717DCF8509283" modified="2015-07-22" version="1">MAVETPRADAPDTATPVWNDPAHDIGTRVSALIDAMTVEEKVAQLFGVWVGASAEGGEVAPYQHEMEEAVDLGALLPAGLGQLTRPFGTAPVDPALGALSLQRTQERVVAAGRFGIPALAHEECLAGFATWGATAYPVPLSWGATFDPALVRRMAAAIGRDMRAVGVHQGLAPVLDVVRDVRWGRVEETIGEDPYLVGTVATAYIQGLQSAGVLATLKHFVGYSASRAGRNLAPVAVGERERADVLLPPFEMALRESGVGSVMSSYTDTDGVPSAADASLLTGLLRDTWGFDGTVVADYFGISFLRTLHGVAGDWAGAAGAALAAGVDVELPTVKTFGPPLLAALADGRVDEGLVDRALRRVLTQKVRLGLLDAGWSPVPEALADAGAEAEPGAVRGTVDLDSAGNRELAREVAEQSVVLLANDGTLPLRGPRRIALVGPNADEPHAVLGCYSFPVHVGVKHPGTPVGIGLPTLHEALRREFPEATVTVAAGCSVDGPETDGIAGAVRAAREADVVIAALGDRAGLFGRGTSGEGCDAESLALPGVQQDLLDALLESGTPVVPVLLAGRPYALGRAADEAAAIVQSFFPGEEGTTAVAGVLAGRTNPSGRLPVSVPRGPGAQPTTYLAPRLGQANEVSNVDPTAAFAFGHGLSYTTFAWSGLEVAAYECATDGEFALSFTLRNTGERDGTEVVQLYLHDPVASVVQPVQRLVGYARVALHAGEERRVRAVVPADVASFTGRDGRRVVEPGALELRLSASSAAPRLTAEVTLTGPPRYVDHTRRMHAEFDPHRDPDTPAAVPDGEPHGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MY21</accession>
    <name>A0A0F7MY21_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ROK family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_01975</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014504.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_01975"/>
    <dbReference type="EnsemblBacteria" id="AKH81140">
        <property type="protein sequence ID" value="AKH81140"/>
        <property type="gene ID" value="AA958_01975"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_01975"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.426"/>
    <dbReference type="OrthoDB" id="1130699at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
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        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01125">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH81140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="324" mass="31231" checksum="6A575EF7E7521DED" modified="2015-07-22" version="1">MVAAQPTELVAALDIGGTKTAAALVDVGGRLVARAQRPTPAAADGATIAAAVTGVLRELAAADPAGWARATAVGIGSAGPVDASVGTVSPVNIPGWRDYPLVAAVSEAAGGLPVVLVGDGVAMAAAEHWQGAARGRSAALCMVVSTGVGGGLVLDGRPYPGPTGNSGHIGHISVDLDGDPCPCGGRGCVERIASGPNIARRALAAGWTPGPEGDDTAAGVAAAARAGDPVALASFDRAAKALAAGIAATATLVEIEAAVIGGGVAAAGELLFAPVRQHLKAYAALSYAAEVAVVPAHLGTDAGLIGAAAVAAQTLGLRRFTAPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-10-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MYP5</accession>
    <name>A0A0F7MYP5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_00220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH80851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH80851">
        <property type="protein sequence ID" value="AKH80851"/>
        <property type="gene ID" value="AA958_00220"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_00220"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH80851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="64" mass="6782" checksum="2CA759735E315F66" modified="2015-07-22" version="1">MPPGLGAQQVRDGVRVAGAEREQHVYGTPEAHGPRRSCAMCTTVHQSPVSTVARGGLRRSLIST</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MZT1</accession>
    <name>A0A0F7MZT1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_06000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015183.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH81830">
        <property type="protein sequence ID" value="AKH81830"/>
        <property type="gene ID" value="AA958_06000"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_06000"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1254"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002518976" evidence="2">
        <location>
            <begin position="29"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH81830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="100" mass="10374" checksum="AE832ABB039D7935" modified="2015-07-22" version="1">MNVTMKRAAVTAVAALAVLLGTAGAASAAEGHAAPQRPCATQGKHVSHGPAGPAGQTGKRVHVKDVPRGHCKKTKRTHARGERKPVKKVVVRDGLRGPRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N019</accession>
    <name>A0A0F7N019_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Mechanosensitive ion channel protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_06465</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_06465"/>
    <dbReference type="EnsemblBacteria" id="AKH81910">
        <property type="protein sequence ID" value="AKH81910"/>
        <property type="gene ID" value="AA958_06465"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_06465"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1350"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="85"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH81910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="359" mass="39675" checksum="55A53375482B21CE" modified="2015-07-22" version="1">MSTEDVLRPVLVIGGAVAVTAIAGVVVDLLLRRADARHPETPIWGLLRSCRAPLQFALLTSILLGTYKRADLAHGDDSRTIVTRVLTLLLIASLAWLLTKVLAAAVELTYHRYKARARDSARRRRVRTQLTLIQRVVVFVICTVAVASMLLTFPQMRAVGTSMLASAGVIGIIAGIAAQSTLGNLFAGLQIAFGDLVRIGDTVVVEEEWGTVEEITLTFLTVKTWDERRITIPVSYFTSQPFENWSRGGPELTGTVFFHLDHSTPVRELRERLHEVLLGCAHWDGRGWSLVVTDTTPTTMQVRALATARDADALWDLRCMVREELITWLREKHPYALPKVMTAQAPLDGARKGPDVEVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N058</accession>
    <name>A0A0F7N058_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytochrome-c oxidase</fullName>
            <ecNumber evidence="3">7.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Cytochrome aa3 subunit 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">AA958_06860</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome c oxidase subunit 2 family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.9" evidence="3"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015332.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_06860"/>
    <dbReference type="EnsemblBacteria" id="AKH81980">
        <property type="protein sequence ID" value="AKH81980"/>
        <property type="gene ID" value="AA958_06860"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_06860"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1434"/>
    <dbReference type="OrthoDB" id="1654242at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070469">
        <property type="term" value="C:respirasome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045187">
        <property type="entry name" value="CcO_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002429">
        <property type="entry name" value="CcO_II-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001505">
        <property type="entry name" value="Copper_CuA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014222">
        <property type="entry name" value="Cyt_c_oxidase_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036257">
        <property type="entry name" value="Cyt_c_oxidase_su2_TM_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22888">
        <property type="entry name" value="PTHR22888"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00116">
        <property type="entry name" value="COX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81464">
        <property type="entry name" value="SSF81464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02866">
        <property type="entry name" value="CoxB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00078">
        <property type="entry name" value="COX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50857">
        <property type="entry name" value="COX2_CUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0186">Copper</keyword>
    <keyword evidence="9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <keyword evidence="6 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="COX2_CUA" evidence="17">
        <location>
            <begin position="147"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00031399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="AKH81980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="332" mass="36666" checksum="681DCA72F2651330" modified="2015-07-22" version="1">MSHNGSDLPRGHTAAAGGTRSPRRTMRRRLPQALAAGLVLVTLSGCTYKDFPRLGMPTPATEEAPRILSLWQGSWAAALAVGVLVWGLILWSVIFHRRSRTKVEVPAQVRYNLPIEALYTVVPLIVVAVFFYFTARDESKLLETSEKPDHVINVVGYQWSWGFNYLENLDGDAATPAKRPKELDAIPDRDFEAVPKGAEGVYDYGVPATENEQTGNPGPTLVLPKGETVQFVLTSRDVIHSFWVVPFLMKQDVIPGHTNVFEVTPNKEGTFLGKCAELCGTDHSRMLFNVKVVSPEKYQEHLQKLADKGQTGYIPAGIPQTDAARNAETNNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0C5</accession>
    <name>A0A0F7N0C5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Amidinotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_07380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_07380"/>
    <dbReference type="EnsemblBacteria" id="AKH82080">
        <property type="protein sequence ID" value="AKH82080"/>
        <property type="gene ID" value="AA958_07380"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_07380"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1546"/>
    <dbReference type="OrthoDB" id="592329at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH82080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="271" mass="29695" checksum="78CE94F4C8635613" modified="2015-07-22" version="1">MRTASARRYLMCPPAHFAVTYSINPWMDPAKPVDLRLALAQWEDLVTRQRSLGHTVELLEPDPSLPDMVFAANGALVVDGRVLGARFAYPQRSGEAAAQRRWFRAHGFADYHLPEHVNEGEGDFAVTRSWILAGRGFRSSPESHAEAQEYLGRPVIGLDLVDPRFYHLDTALCVLDDSTDTDVMYYPAAFSPGSRDVLARLFPDALLAAEEDALALGLNAVSDGRHVLLPQAAAGLVAPLRARGFEPVPMDLTELLKGGGSVKCCTLELRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0K4</accession>
    <name>A0A0F7N0K4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Beta-N-acetylhexosaminidase</fullName>
            <ecNumber evidence="3">3.2.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_00365</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="3"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH80874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014240.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_00365"/>
    <dbReference type="EnsemblBacteria" id="AKH80874">
        <property type="protein sequence ID" value="AKH80874"/>
        <property type="gene ID" value="AA958_00365"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_00365"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.88"/>
    <dbReference type="OrthoDB" id="727559at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004563">
        <property type="term" value="F:beta-N-acetylhexosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102148">
        <property type="term" value="F:N-acetyl-beta-D-galactosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025705">
        <property type="entry name" value="Beta_hexosaminidase_sua/sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015882">
        <property type="entry name" value="HEX_bac_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600">
        <property type="entry name" value="PTHR22600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02838">
        <property type="entry name" value="Glyco_hydro_20b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00738">
        <property type="entry name" value="GLHYDRLASE20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="SSF55545"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_20b" evidence="7">
        <location>
            <begin position="2"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_20" evidence="6">
        <location>
            <begin position="150"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="477"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH80874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="700" mass="76848" checksum="199FC176315D2BF7" modified="2015-07-22" version="1">MVPRPSLWEDLGGTVDLTSRSRILLDPGSRARTTTEAGRQELPGPARQTGQSLAEQVQADIRSVTGLRLTISSGHVKPRPGDIHLRLTDDAELGAEGYRLDSSSAISIEAASTHGLFYGTRTLLQTLRADSSHRAVPRARSTDVPTQQVRMVQLDAGRKYWEMDYLENLIRRMGDMKLNTLFLQLSDSEGFRLYSPKFPGLAERKYSYSRADIERLKALAARQHVQIMPGIDVPGHATVISEAFGIGFGSGANPCTGAHTHSHLTPDWIIDITDRDAVEVTKRLVAEFTDWFDAPLFSIGADELPGQLAECPRVKRHLAEDPDVSTLGDLLNGYINTLDDVVTAHGKRTAIYNGTEHLAAPQQQVHSPVVFLTWEGTGTDPVIPGHDEIAIGPFYVTPNNYHNLYPDERWMYERWVPNTADDMLGSGLMNWADYNFWAEDRYFEQVMAAPRALLADRAWNGSAVPDTLAGFRARTAALGDPPGITTEPQPPRTDDGHPSHHWTFDAASYPAGWTYASSPPHTIMAEDVAGDLPGTTYIINNPTLVEDGVRGQAFRFDHNRDGVGFGGTDIAAPWTASAWVKLTATTSDQVLLSSRTGALKLQQYGSGKVGFTRFGDADHSFGYTVPLNRWVHLTWVAEPDRTTLYADGEPVGAVNASIPLPLRSIGTPSASLRGDLDELVTWDEALTPAQVQQRYAAYGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0P7</accession>
    <name>A0A0F7N0P7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_04460</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014921.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH81566">
        <property type="protein sequence ID" value="AKH81566"/>
        <property type="gene ID" value="AA958_04460"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_04460"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.940"/>
    <dbReference type="OrthoDB" id="2066190at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH81566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="139" mass="15113" checksum="AAA10706338C907F" modified="2015-07-22" version="1">MTVVYRAPEGDDGLEFTVRLTPEETRVLTREVRLLAEIVDSCLWALGMLRTGVNSRDAGRPAPIPGDWYSALRDLEHIAPRVEGTRDAVIRALAESGEGTGRLAHALHTDEEAASRRRAAVLGNPPSGWETWAAKGVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N1C3</accession>
    <name>A0A0F7N1C3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sulfate adenylyltransferase subunit 2</fullName>
            <ecNumber evidence="2">2.7.7.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">ATP-sulfurylase small subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Sulfate adenylate transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_05980</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PAPS reductase family. CysD subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.4" evidence="2"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015179.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_05980"/>
    <dbReference type="EnsemblBacteria" id="AKH81826">
        <property type="protein sequence ID" value="AKH81826"/>
        <property type="gene ID" value="AA958_05980"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_05980"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1250"/>
    <dbReference type="OrthoDB" id="499077at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004781">
        <property type="term" value="F:sulfate adenylyltransferase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019419">
        <property type="term" value="P:sulfate reduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01713">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002500">
        <property type="entry name" value="PAPS_reduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011784">
        <property type="entry name" value="SO4_adenylTrfase_ssu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01507">
        <property type="entry name" value="PAPS_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002936">
        <property type="entry name" value="CysDAde_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02039">
        <property type="entry name" value="CysD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAPS_reduct" evidence="7">
        <location>
            <begin position="38"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="286"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH81826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="308" mass="35204" checksum="1F289ACDB893EFF7" modified="2015-07-22" version="1">MSRFEQAAAQDFQLPHLDVLESEAVHIFREVAGEFERPVILFSGGKDSIVMLHLALKAFAPAPPPFALLHVDTGHNFPEVLEYRDRVAAQHNLRLHVASVQEFIDRGELKERADGTRNPLQTVPLLRAIEEARYDAVFGGGRRDEEKARAKERIFSLRDEFGGWDPRRQRPELWQLYNGKHAVGEHVRVFPLSNFTELDVWQYIAREKIVLPEIYYAHRREVFLRSGMWLAPGEWGGAKQGERVETRTVRYRTVGDMSCTGAVDSDADTIEKVIAEIAATRLTERGATRADDKMSEAAMEDRKREGYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N221</accession>
    <name>A0A0F7N221_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_07185</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015391.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_07185"/>
    <dbReference type="EnsemblBacteria" id="AKH82041">
        <property type="protein sequence ID" value="AKH82041"/>
        <property type="gene ID" value="AA958_07185"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_07185"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1505"/>
    <dbReference type="OrthoDB" id="1437290at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="17"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH82041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="208" mass="22607" checksum="7FA590D5F5B5EF93" modified="2015-07-22" version="1">MADPGTPVPGLRERKKQRTRRLLSETAVRLFLERGYDAVSVAEVAAAAEVSKPTLFRYFPSKEDLVLHRFADHQDEAARVVTARAEGESPLAALRRNFLDGLERRDPVTGLCDDPAVIAYQRLLYGTPSLVARLAGWQERSERVLADALGGPAVRARLAAGQIAAVQRILAEENVRRIADGESADAVAPDAKEAAELAFRQLAKGIGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2H6</accession>
    <name>A0A0F7N2H6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycine dehydrogenase (decarboxylating)</fullName>
            <ecNumber evidence="7">1.4.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Glycine cleavage system P-protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Glycine decarboxylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Glycine dehydrogenase (aminomethyl-transferring)</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">gcvP</name>
        <name evidence="9" type="ORF">AA958_01525</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 7">The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>(R)-N(6)-lipoyl-L-lysyl-[glycine-cleavage complex H protein] + glycine + H(+) = (R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysyl-[glycine-cleavage complex H protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:24304"/>
            <dbReference type="Rhea" id="RHEA-COMP:10494"/>
            <dbReference type="Rhea" id="RHEA-COMP:10495"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="1.4.4.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4 7">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the GcvP family.</text>
    </comment>
    <dbReference type="EC" id="1.4.4.2" evidence="7"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014427.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_01525"/>
    <dbReference type="EnsemblBacteria" id="AKH81062">
        <property type="protein sequence ID" value="AKH81062"/>
        <property type="gene ID" value="AA958_01525"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_01525"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.335"/>
    <dbReference type="OrthoDB" id="70707at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004375">
        <property type="term" value="F:glycine dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00613">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00711">
        <property type="entry name" value="GcvP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003437">
        <property type="entry name" value="GcvP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020581">
        <property type="entry name" value="GDC_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11773">
        <property type="entry name" value="PTHR11773"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02347">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00461">
        <property type="entry name" value="gcvP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7 8">
        <location>
            <position position="713"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR603437-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH81062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="965" mass="102190" checksum="79499B182419DA21" modified="2015-07-22" version="1">MSETNAHRIPLSALERGTPFEQRHIGPDAGDRAKMLAQVGYGSLDELTEAAVPGSIKGTGAFTLPAARSEAEVLAELRGLAARNEVLTSMIGLGYHGTHTPPVILRNVMENPAWYTAYTPYQPEISQGRLEALLNFQTVVSDLTGLPTAGASLLDEGTAAAEAMALSRRVGKVKDGVFLVDADTLPQTVAVLRTRAEPTGVEVVVADLARGIPAEAAERGVFGVLLQYPGASGAVRDLTPVIERAHELGAVVTVAADLLALTLLTSPGSLGADIAVGSSQRFGVPMGFGGPHAGYMSVREKFARSLPGRLVGVSRDTDGAQAYRLALQTREQHIRREKATSNICTAQVLLAVMASMYAVYHGPEGLAAIARRTHRFAAVLAAGLRAGGADVVHDAFFDTVTVRVPGRAAEVTARARNAGVNLRLADADHVGISCDETTVREHLAVVWDAFGVPGRDVGELDAATADALPAGLLRTDEYLTHPVFHRHRSETALLRYLRTLADRDYALDRGMIPLGSCTMKLNATAEMEAVTWPEFAGLHPFAPADQAAGYLTLIRELEEGLAAVTGYDKVSLQPNAGSQGELAGLLAVRAYHRANGDERRTVCLIPSSAHGTNAASAVMAGMKVVVVKTAENGEVDVDDLRAKIGQYGDELAVLMVTYPSTHGVFEEHITEICDAVHAAGGQVYVDGANLNALVGLAGPGKFGGDVSHLNLHKTFCIPHGGGGPGVGPVAVREHLAPYLPNHPLQPAAGPETGVGPVSAAPWGSAGILPISWAYMKLMGEDGLRRASQVAVLGANYVAKRLEPHFPVLYTGPGGLVAHECIVDVRPLTKATGVSIDDVAKRLIDYGFHAPTMSFPVAGTLMIEPTESENLSELDRFCEAMIAIRREIERVGTGEWDKDDNPLVGAPHTAAQLAGEWKHPYGRAEAVFPAGVTPADKYWPPVRRIDGAYGDRNLVCSCPPLDEYDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2J1</accession>
    <name>A0A0F7N2J1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_01645</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014446.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_01645"/>
    <dbReference type="EnsemblBacteria" id="AKH81082">
        <property type="protein sequence ID" value="AKH81082"/>
        <property type="gene ID" value="AA958_01645"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_01645"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.361"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH81082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="129" mass="14109" checksum="E230CB482DD2E425" modified="2015-07-22" version="1">MAAEEELRRPESPLWVEEPVGTPRLPDPVRTAAVRAVIIVAVTLSQAMAALLFTVSGSWPAFPLLLSTVVSTVVATWGVLDVWVTRQVWKQRYGVESRPSSAARRARRERRGGRRTQRGRPPGAVAAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2K3</accession>
    <name>A0A0F7N2K3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_04780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014978.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH81623">
        <property type="protein sequence ID" value="AKH81623"/>
        <property type="gene ID" value="AA958_04780"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_04780"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1007"/>
    <dbReference type="OrthoDB" id="1459004at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="228"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH81623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="332" mass="35734" checksum="41179B4A1DBBAEBA" modified="2015-07-22" version="1">MSPPPKPPVPRHVVGVAVTDGTPAYELAVPCEVFGLDRSDLVDPWYELRLCAAQPGPLATAPGLLLQSPYGLADLAEADTVLIPGLTRSLQLDPPPGLVAAVRKAYEAGKRIVTLCAGAYVPAAAGVLDGRRATTHWMNAADFTHRFPGVRVEADALYCEDGPVFTSAGTGAAVDLCLHLVRRDHGAAVANEVARRMVVPPHREGGQAQYARLPPAPARPAAPGHGLAPVLDWARARLHEPLTVAALARTAHLAERTFARRFRDTLGVTPLQWLLQERVRLAQELLETTDVPVEAVARRAGLGSAANLRHQFARQTGVSPRTYRHVFRDRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2M0</accession>
    <name>A0A0F7N2M0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Prephenate dehydrogenase</fullName>
            <ecNumber evidence="4">1.3.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AA958_04910</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>NAD(+) + prephenate = 3-(4-hydroxyphenyl)pyruvate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:13869"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
            <dbReference type="ChEBI" id="CHEBI:36242"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.3.1.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-tyrosine biosynthesis; (4-hydroxyphenyl)pyruvate from prephenate (NAD(+) route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the prephenate/arogenate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.12" evidence="4"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014998.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_04910"/>
    <dbReference type="EnsemblBacteria" id="AKH81643">
        <property type="protein sequence ID" value="AKH81643"/>
        <property type="gene ID" value="AA958_04910"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_04910"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1033"/>
    <dbReference type="OrthoDB" id="533829at2"/>
    <dbReference type="UniPathway" id="UPA00122">
        <property type="reaction ID" value="UER00961"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008977">
        <property type="term" value="F:prephenate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004665">
        <property type="term" value="F:prephenate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006571">
        <property type="term" value="P:tyrosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003099">
        <property type="entry name" value="Prephen_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02153">
        <property type="entry name" value="PDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51176">
        <property type="entry name" value="PDH_ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0827">Tyrosine biosynthesis</keyword>
    <feature type="domain" description="Prephenate/arogenate dehydrogenase" evidence="7">
        <location>
            <begin position="2"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="8">
        <location>
            <begin position="294"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH81643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="361" mass="37511" checksum="0D96D034C8315D15" modified="2015-07-22" version="1">MRTALVIGTGLIGTSAALALSRRGVTVHLQDEDADQARTAASLGAGTDQPPAAPVDLAVVAVPPALTGRTLADAQRRGAARGYLDVASVKSGPRRTLEELGGDLTSYIGSHPMAGSERSGPLAASAELFEGRPWVLSPAESTDTEVLNLALELVALCRAVPVVMDADAHDRAVALVSHTPQLVSSMVAARLRDAEEAAVRLCGQGIRDVTRIAASDPAMWIDILSANPGPVAEVLAEVAADLDETVRALRALQAADDAKRRTGAAGIEDVLRRGSAGRERVPGKHGAAPADYETVTVLIGDRPGELARIFADAGAAGVNIEDVRIEHATGQQAGRVQLMVEPPAAHALTAALRERGWPLRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2X0</accession>
    <name>A0A0F7N2X0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ArsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_05595</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015113.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_05595"/>
    <dbReference type="EnsemblBacteria" id="AKH81759">
        <property type="protein sequence ID" value="AKH81759"/>
        <property type="gene ID" value="AA958_05595"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_05595"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1172"/>
    <dbReference type="OrthoDB" id="1288973at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="2">
        <location>
            <begin position="25"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH81759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="253" mass="26769" checksum="D4313793C67EF302" modified="2015-07-22" version="1">MDPGGSTAKEQAAGPAAGAVVPGDGTRNRVARSILDHGPSTAADLAHRLELTPAAVRRHLDVLVAEGIVEPRDQRVYGTRGRGRPAKVFALTDCGRDAFDHAYDQLAADALRWIAQSAGGGVRGEAAVAAFARDRVAEQAERYAAELAGMPPESRVEALARLLSEDGYAATARSAPGAPGEQLCQHHCPVAHTAEQYPQLCEAETEVFSRLLGTHVQRLATIAHGDGVCTTFVPEIREPHARRQPPTSGRNPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N307</accession>
    <name>A0A0F7N307_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Triosephosphate isomerase</fullName>
            <shortName evidence="3">TIM</shortName>
            <shortName evidence="3">TPI</shortName>
            <ecNumber evidence="3 4">5.3.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Triose-phosphate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">tpiA</name>
        <name evidence="5" type="ORF">AA958_05685</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:18585"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="5.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the triosephosphate isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.1" evidence="3 4"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015127.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_05685"/>
    <dbReference type="EnsemblBacteria" id="AKH81774">
        <property type="protein sequence ID" value="AKH81774"/>
        <property type="gene ID" value="AA958_05685"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_05685"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1190"/>
    <dbReference type="OrthoDB" id="1266295at2"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00189"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004807">
        <property type="term" value="F:triose-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00311">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00147_B">
        <property type="entry name" value="TIM_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035990">
        <property type="entry name" value="TIM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022896">
        <property type="entry name" value="TrioseP_Isoase_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000652">
        <property type="entry name" value="Triosephosphate_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020861">
        <property type="entry name" value="Triosephosphate_isomerase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139">
        <property type="entry name" value="PTHR21139"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00121">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51351">
        <property type="entry name" value="SSF51351"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00419">
        <property type="entry name" value="tim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00171">
        <property type="entry name" value="TIM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51440">
        <property type="entry name" value="TIM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 3 4" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="3 4" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="2 3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="14"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="243"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="active site" description="Electrophile" evidence="3">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH81774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="261" mass="28082" checksum="E11AA1701124DF78" modified="2015-07-22" version="1">MNDKPTRIPFMAGNWKMNLNHLEGIAHVQKLAFALHDKDYEAVEVAVLPPYTDLRSVQTLVDGDKLKIKYGAQDISPHDAGAYTGDVSGPMLAKLHCTYVVVGHSERRQYHGEDDALVNAKVKAAFKYGITPILCIGEGLEVRKAGEQVAYTLAQLDGALKDVNAADAESIVVAYEPVWAIGTGEVATPDDAQEVCGAIRQRLAELYSEEVAAAVRIQYGGSVKSGNVAAIMAQPDVDGALIGGASLDADEFVKIVRFRDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N344</accession>
    <name>A0A0F7N344_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_09495</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015765.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_09495"/>
    <dbReference type="EnsemblBacteria" id="AKH82421">
        <property type="protein sequence ID" value="AKH82421"/>
        <property type="gene ID" value="AA958_09495"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_09495"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2002"/>
    <dbReference type="OrthoDB" id="1087123at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH82421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="360" mass="38318" checksum="6541AE0448F48B0A" modified="2015-07-22" version="1">MAGHEGPPDGTPERAPGGGDDEYRSIVFDEAFVKAARLEEYSASERVGDHAPAVRSRRPQRPGASRQALVLVLLIALAFGTAIYMGVRMPYRQPGAPAAAPLRSTVVPLTPDGPVPGGEPDELIAGSPAADFGTGADGIDLPDPDATRNFTEEQVVQALTASKDYLVTSAVDARTLTGGNVRDVRIQLDPQQHGQFDQSLARPADDGRHAATGWMVRLDPEHVRLADRKVRVDGAVTFAEVSDEELEVSADHVFVYVLRPAKASGGAPEAKASLFTVRRQVRIRFDHDDLRDRQLELAETALTAGPLACTADASVYLRPLLAGERDPRKTPHGTNPFATPGQLSGSLCGVLDTGQAAKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N381</accession>
    <name>A0A0F7N381_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aminopeptidase N</fullName>
            <ecNumber evidence="4">3.4.11.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Alanine aminopeptidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Lysyl aminopeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">AA958_09750</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal amino acid, Xaa-|-Yaa- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide.</text>
            <dbReference type="EC" id="3.4.11.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.2" evidence="4"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015809.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_09750"/>
    <dbReference type="EnsemblBacteria" id="AKH82466">
        <property type="protein sequence ID" value="AKH82466"/>
        <property type="gene ID" value="AA958_09750"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_09750"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2055"/>
    <dbReference type="OrthoDB" id="771837at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012778">
        <property type="entry name" value="Pept_M1_aminopeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="SSF63737"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02412">
        <property type="entry name" value="pepN_strep_liv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase_M1_N" evidence="15">
        <location>
            <begin position="109"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M1" evidence="13">
        <location>
            <begin position="233"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="ERAP1_C" evidence="14">
        <location>
            <begin position="537"/>
            <end position="846"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AKH82466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="860" mass="94681" checksum="69D79040F849F5F3" modified="2015-07-22" version="1">MPGTNLTREEAQERARLLKVDAYEIDLDISGAKEAAEGGTFRSVTTVRFSAAEEGAETFADLIAPEVHEVVLNGTALDAAEVFADSRIALRGLRAGENELRVVADCAYTNTGEGLHRFVDPVDGETYLYTQFEVPDARRVFATFEQPDLKATFAFTVTAPEGWQVISNSPSPEPAAGVWRFTPTPRMSTYITALIAGPYTSVHGTWEGDGRTVPLGVYCRPSLAEFLDAEAIFDVTRQGFDWFQKRFDYPYPFEKYDQLFVPEFNAGAMENAGAVTFRDQYVFRSKVTDAAYEMRADTILHELAHMWFGDLVTMEWWNDLWLNESFATYSSTACLAQAPGSRWPHAWTSFANQMKTWAYRQDQLPSTHPIMAEITDLDDVLVNFDGITYAKGASVLKQLVAYVGEDEFFRGVQAYFKRHAFGNTRLSDLLGALEETSGRDLAAWSKAWLETAGINVLRPELETGADGVVTSFAIRQEAPALPAGAKGEPVLRPHRIAVGLYDLKDGRLVRTDRLELDIDGELTDVPQLAGRPRPAVVLLNDDDLTYAKVRLDPASLDVVTRHLGDFETTLPRALCWASAWDMTRDGELATRDYLDLVLSGIRKESDIGVVQSLHRQVKLALDLYAAPDWRETGLARWSAEAETRLHAAEPGGDHQLAWARALAATARTDGQLDLLAGLLDGSRTIEGLDVDTELRWALLHRLAATGRAGEDAIAAELERDKTAAGERHAASARAAQPTAAAKSRAWTEVVEEGNLANAVQEAVIAGFVQTDQRELLAPFTAKYFDAVKDVFDSRSHEIAQQIVVGLYPALQVSQATLDATDAWLTETQPSPALRRMVTESRAGVERALRAQQADAAAATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3K8</accession>
    <name>A0A0F7N3K8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_10760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015966.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_10760"/>
    <dbReference type="EnsemblBacteria" id="AKH82626">
        <property type="protein sequence ID" value="AKH82626"/>
        <property type="gene ID" value="AA958_10760"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_10760"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2263"/>
    <dbReference type="OrthoDB" id="1442962at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="SSF52499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="195" mass="20190" checksum="2816D2109592B606" modified="2015-07-22" version="1">MHRALIVVDVQNDFCEGGSMGVTGGADVAAAITDLIGRSTAGYQHVVATRDHHIEPGDHFSAHPDFVHSWPRHCVAGTEGVGFHPNFAPTVASGAISAVFDKGAYAAAYSGFQGADENGVPLADWLRAREVTEVDVVGIATDHCVKATALDAAAEGFRTQVLLDLTAGVAEDSTQRALGELSEAGVELTGKPVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3X7</accession>
    <name>A0A0F7N3X7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Family 2 glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_11380</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016068.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_11380"/>
    <dbReference type="EnsemblBacteria" id="AKH82731">
        <property type="protein sequence ID" value="AKH82731"/>
        <property type="gene ID" value="AA958_11380"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_11380"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2394"/>
    <dbReference type="OrthoDB" id="1502976at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="468"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="576"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="629"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="727"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="751"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="781"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="814"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="422"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1083"/>
            <end position="1269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1129"/>
            <end position="1147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH82731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="1269" mass="131109" checksum="1EC0E1114296F039" modified="2015-07-22" version="1">MSEHSNADFAAGYPAAADAAGRPGTTAAAPGGGTPAFPRHVVTAVLVSHDGERWLPDALAALTAQERPVQSVIAADTGSADGSARILTEALGAERVLHLARRTGFGTAAAEAARTAGVLTPDQLPYLRRPSGWDPVSRSWRDDAYDMPEFPHGEPVQWLWLLHDDCAAEPDALAAMLRLADDMPSAAIIGPKLRSWYDRRQLLEAGVSIAHSGRRWTGIDRREQDQGQHDGVRDVLSVSTAGMLIRRDVFDQLGGFDARLPLMRDDVDLCWRAHKAGHRVVVQPDAVMRHAEAAARERRSIDCMGRSGQTAKGASPHRVDKAGAAYTLLVNSSAAALPYIAFRLVLGTLLRTLAYLVGKVPRQALDEVAGLGAVLLRPHRIAAARRRRGKPAVPPGDLKPLFPGRGATVRVTVEQVLSNFSGRSEPELSGGGRHGGAVETGPGDDDADFLEVEQFARLKRVARKPGPVLFAVLLLVALIACRELIGGGTLIGGALLPAPADAGDLWSSYADSWHPVGTGGTQDAPPYLAFLAGLGTVLFGSTNAALTLLLVCSVPLAGFTAYFASRPLVSSRLLRAWGSVAYAFLPAATGALAAGRIGTAVLAVLLPLLARAAVAASGLRGRASWRGAWAYALLLTVTTAFTPVVWPLAALLAAAPAAWAVVRGRSPVGPGLRQLAVLVTPVVLLAPWSLDLLTEPSRFFTEAGLDTTTDDVSPLGLLLASPGGPNAGGSVLLAGIVLAALAALFRSDRRLPVGAAWAVAAVAGLLAAAGAGDGWTGPQTLVYGLALLAAAVIGADGARHRVAEQSFGWRQPAAVLVAVACAVGPLVLAVGWMWRGADGPLERGGADQVPAFVAEESRTSDQPRTLVVGGSAAQVEYMLVRGAGARLGDAELAAAGGGNSRLSGTVSGLVAGSGADQSAELGAYAVRYVLVRNDAPRTFGRVLDATPGLTRLSQQDGGALWRVDARVSRATVVAGDGEGQGAAEPVPVPAGPVEVHTDIEDGPEGRVLRLADAASAGWRATLDGEPLEATTVDGWAQGFELPAGGGRLDVTYDTAVTHTAWTWARGAALLVVLVLALPGRRRDVDDDLPEAGTPAIPAQALEGDGRRARRLRAQAAAAEAEGAGAPGGAPEAPPMPPAPPGSPAVPGAPDEQPAWAAAPVPGAGQAEQGYGDTSVADPYAAPPQGYEWDGTGYGGQYGGTSYEAPYEPQYDAGAYESEQRPGAPAVPQQGGQGYGDGEQDPYGAGQYSGPYYDQRNYGAGAERDGSDNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3Y0</accession>
    <name>A0A0F7N3Y0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F420-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_04465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014922.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_04465"/>
    <dbReference type="EnsemblBacteria" id="AKH81567">
        <property type="protein sequence ID" value="AKH81567"/>
        <property type="gene ID" value="AA958_04465"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_04465"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.941"/>
    <dbReference type="OrthoDB" id="1434838at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019952">
        <property type="entry name" value="F420_OxRdatse_Rv1855c_pred"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03560">
        <property type="entry name" value="F420_Rv1855c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="307" mass="33039" checksum="F9839DE4FC3D1DF6" modified="2015-07-22" version="1">MDLRIFTEPQQGASYDTLLTVARATEDLGFDAFFRSDHYLKMGDVSGLPGPTDAWVTLAGLARETRRIRLGTLMTAATFRLPGPLAIQVAQVDQMSGGRVEMGIGAGWFEDEHAAYGIPFPKEKFARLEEQLAIVTGLWGTPTGETFSYSGTHYELRDSPALPKPVQAPLPVLIGGMGPKRTPALAARYAAEFNVPFSSAADTERQFARVREAAEAAGRSPSDLVYSNALVACVGKDDAEVARRAAAIGREVPELKENGLAGTPAEVVEKLGRYAAAGSQRFYLQILDLSDLDHLELIAAEVLAQVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3Y7</accession>
    <name>A0A0F7N3Y7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_15200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016654.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_15200"/>
    <dbReference type="EnsemblBacteria" id="AKH83340">
        <property type="protein sequence ID" value="AKH83340"/>
        <property type="gene ID" value="AA958_15200"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_15200"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3202"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="5"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="268"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="307"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="338"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="363"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="394"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="427"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH83340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="453" mass="44947" checksum="C5E46A5196741C31" modified="2015-07-22" version="1">MAACFYAYSFLDDFVLLYPVYALLFADHGLSLWQVSSLFVIWSLTSLLLEVPSGAWADAFSRRLLLCAGPLLSGAGFALWILAPSYWAFAAGFVLWGAKGAFASGALEALLYEELGRAGAAETYARTLGRGRAAGTVGVMASMAAAAPVFAAGGYAAVGAASVASCLLGAAVATRFPEHRAAAAGAETVRGAGPAGGEAAPDGEPPPGGNAGGSGSARRGDGPGASSGADAGPPADADAGPEPDGSDDPELGWAGTLRAGFAELRAEPSVRGALLLVPAVVAVWGSLDEYTPYLVREAGVADPAVPLYLLLIWAGAAAGGLLAGRVEERGRAARTPAGVLAALLAGSAVALAAGGLLGTAVGIALVGVAFGGFQVATVLAEARLQERITGPARATLTSLAGVGTDLGTIAVYGAYGLLGSAAGLGHGAAFAVCALPYLVVAPLLLRGRGRQRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N400</accession>
    <name>A0A0F7N400_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_07535</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5 6">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the group II decarboxylase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015458.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_07535"/>
    <dbReference type="EnsemblBacteria" id="AKH82108">
        <property type="protein sequence ID" value="AKH82108"/>
        <property type="gene ID" value="AA958_07535"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_07535"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1579"/>
    <dbReference type="OrthoDB" id="1478871at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010977">
        <property type="entry name" value="Aromatic_deC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021115">
        <property type="entry name" value="Pyridoxal-P_BS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00800">
        <property type="entry name" value="YHDCRBOXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00392">
        <property type="entry name" value="DDC_GAD_HDC_YDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="4 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="5">
        <location>
            <position position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH82108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="499" mass="52849" checksum="3FACF8FAF8FEE3C7" modified="2015-07-22" version="1">MSQRDLSPEEFRELGHAYVDWIADYRARVGDLPVLPGVEPGWVRERLPAKLPEEGEPLTEVLADMDRVVVPGSTHWQHPGFFAYFPANASLASLLGDMLSTGLGSQGMLWSTSPACTELEQHLLDQLADATGLPAEFTFAGGGGGVIQDSASSSSLVALLAALHRTSGGAWRTAGRDGREVLYVSAHTHSSLEKAAIAAGLGADAVRIVPPGGDGGQTMAPDALAAAVREDLGAGRRPVMVCATIGTTGTGAVDPVREIAAVCAEYGIWLHVDAAWAGAAAFCPEHRGLFDGAGLADSYSTDGHKWLLTAFDCNLFWTRDTATLVGALTVLPEYLRNAASESGAVVDYRDWHLPLGRRFRALKLWTVLRRFGLAGIRDHVRRHVGLAAELESWAAADPRFALGVPRSLALVCLYAVTGRGMDADNAATKAVLERINAGGRSYVTHTVVDGRYLLRVAVGGLETEERHVRVLWDDLCAAADAVTGADAAAAVEAGESRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N498</accession>
    <name>A0A0F7N498_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_08155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015558.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH82208">
        <property type="protein sequence ID" value="AKH82208"/>
        <property type="gene ID" value="AA958_08155"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_08155"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1718"/>
    <dbReference type="OrthoDB" id="1661714at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00552">
        <property type="entry name" value="HTH_MERR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="16"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="137" mass="15479" checksum="46A0A92F164F9523" modified="2015-07-22" version="1">MSLTTAARVRPVGQDHYSISEVASYTGLSAHTLRWYERIGLLNGVHRSHTGQRLYTDGDLDWLDLIGKLRLTGMPVADMVRYAELVRAGDQTMPERTQLFREHREVVRQQIANLQTTLAVLDFKIEFYEGAASGCTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4A0</accession>
    <name>A0A0F7N4A0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Multidrug transporter MatE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_16060</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_16060"/>
    <dbReference type="EnsemblBacteria" id="AKH83470">
        <property type="protein sequence ID" value="AKH83470"/>
        <property type="gene ID" value="AA958_16060"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_16060"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3384"/>
    <dbReference type="OrthoDB" id="1415498at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13136">
        <property type="entry name" value="MATE_DinF_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044644">
        <property type="entry name" value="DinF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42893">
        <property type="entry name" value="PTHR42893"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="62"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="288"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="331"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="363"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="396"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="424"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH83470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="457" mass="46798" checksum="92603F8D78738E50" modified="2015-07-22" version="1">MHDVPATTAAGQGTPGEQRRRIRRRHDREIVALAVPAFGALVAEPLFVLADSAIVGHLGTPHLAGLGVAAALLTTAVSVFVFLAYATTAAVARRVGAGDLRSAIQQGVDGIWLAALLGAVLVAVTVPAAPRLVGLFGASDTAAPYAVTYLRISAFGIPAMLIVFAATGVLRGLQDTRTPLYVAIGGFTANAVLNIALVYGAGLGIAGSAWGTVLAQWGMAAVYLVVVVRGARKHGAALRPQPAGIRASARAGVPLLIRTLSLRAIGLIATAVAAGLGDESVAAHQVVLSIWSLLAFALDAIAIAGQAIIGRYLGAGDVDGAREACRRMVQWGVATGAVLGALVVAARPLILPLFTDDARVHDVLLPALLVVAVTQPLAGVVFVLDGVLMGAGDGPYLAWAMLLTLAVFAPVALAVPSLGGGLTAVWWSMGLMMLTRLVTLWLRARSGRWLVTGAVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4D1</accession>
    <name>A0A0F7N4D1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_08275</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015579.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_08275"/>
    <dbReference type="EnsemblBacteria" id="AKH82229">
        <property type="protein sequence ID" value="AKH82229"/>
        <property type="gene ID" value="AA958_08275"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_08275"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1746"/>
    <dbReference type="OrthoDB" id="1593423at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021424">
        <property type="entry name" value="PorA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11271">
        <property type="entry name" value="PorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH82229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="336" mass="37094" checksum="B77CD76EF66B2303" modified="2015-07-22" version="1">MSRRTASPLSLILLGLGVFLLVLAPMLAFYVEPRAKLNPVDIESTTRYEGTGTFYDTETQKERNNQELTIVRRVLGDVAASDDDTAVWDAATTIDTPLTREIDDPRRAFQFTTERWVMNRETNAPEHCCDEDTGVDGNRFGGDAYLKFPFDVEKRTYRWWDSTAQDTVALKYDGTREIQGYTGLAFTGEIEPVKTGTRQVPGVMVGLPDKEQVFADEWYANEKIELVADERTGRIIYASIAPKKTLRQPGGGTDEVTLLQSDGIAFTEETQKEQVDLADEDSSRLKLVGETLPVVALVAGFVLAGAGAVLLARGGRRDEPDRGREPDGVPPQPVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4J0</accession>
    <name>A0A0F7N4J0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Carbamoyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_08740</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NodU/CmcH family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015650.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_08740"/>
    <dbReference type="EnsemblBacteria" id="AKH82303">
        <property type="protein sequence ID" value="AKH82303"/>
        <property type="gene ID" value="AA958_08740"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_08740"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1844"/>
    <dbReference type="OrthoDB" id="509293at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.870.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031730">
        <property type="entry name" value="Carbam_trans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038152">
        <property type="entry name" value="Carbam_trans_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003696">
        <property type="entry name" value="Carbtransf_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16861">
        <property type="entry name" value="Carbam_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02543">
        <property type="entry name" value="Carbam_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbam_trans_N" evidence="2">
        <location>
            <begin position="33"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="Carbam_trans_C" evidence="3">
        <location>
            <begin position="419"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH82303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="594" mass="64504" checksum="CC569516477BB4A0" modified="2015-07-22" version="1">MIVLGYNGFTRAAGLFRRHYGATGVDRHLLIGHDAAAALVVDGELIAAVEEERLSRTKKTADFPARAIAWCLRKAGISLEQVDVFAFPWSFSRPVMEGMIEEVLRARMPLSGTFDHLHRLGELYTGMLSAEAIHADFVARTGYDVDPNRLVPVSHHLAHAMCGYHVSGVRHAAFLVSDGRAEHASAITGEIHDGVIRQRDLGTVAMRDSLALFYGKVTRYLGFVPNCDEYKVMGLAGYGRPPARNVLLDRLVELHEGGGYSISAPADTQACGALFDMLFDGSPHAREGFDYRVKVASTVQHLVETVTAHQVRALAAATGLDTLIVEGGLALNCVANTKMLNQSPFRDMHVSFGASDPGVAIGAALCVAGARRGGEAVAEHSPYLGPSYDEDDVLAALTARRDEVSWRVVPGGAVADEAAKLLVEKNVVGWFQGPVEYGPRALGNRSILANPQHADIKDIINLRVKRREPFRPFAPVVLEEDAPSVFEMGKKTRSPYMTFVFPVREEWRERIPGACHVDGTARIQTVSPRQNAELAGLLRSFTALTGVPCLLNTSFNVAGEPIVASPEDALSCFLRTEIDYLVLGDVIVEKSSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4X7</accession>
    <name>A0A0F7N4X7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PLD phosphodiesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_09540</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015773.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_09540"/>
    <dbReference type="EnsemblBacteria" id="AKH82429">
        <property type="protein sequence ID" value="AKH82429"/>
        <property type="gene ID" value="AA958_09540"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_09540"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2011"/>
    <dbReference type="OrthoDB" id="1881748at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519250" description="PLD phosphodiesterase domain-containing protein" evidence="1">
        <location>
            <begin position="37"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="2">
        <location>
            <begin position="358"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH82429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="449" mass="48668" checksum="33327BCF6FCCBC75" modified="2015-07-22" version="1">MSVFKPTGRHRAVSPRKGARQAVALATVLSAAGAHAVSSAGGAAAEPRVWIEGPIFNDPLGTVDEQHAIRTRLIELTDAAVPGSVIKVAVYHIWEQPVVDALVRARARGVNVQVLLDESSRSDRPDNTMYASLKAALGTSTTAGSFVKLCPVDKSCLGDPKFGASIMHNKFWLFSEVEGARNVVVQTTSNSTPSAHTKFFNDALLLPDNPAMYGAYAEYFRDMVGAQWSTWRYRAVTASNGLYKAYFFPRSGTTNSTDTIHAVLDNVRCTYRDSAGVTRRTLVRVAIFKITRKAIADKLVALKKAGCGVSLVYAESDSARSQGGTPGTWEVLHASGGPSLRCYNDDRDPQNPGQKLTTPYIVHNKYVLIDGMYAGSRDKLVFTGSQNFTGPALRENDEAVVKIDSDPVHDTYLGHYTSVRAVAWPGTADRTNLCQGVKSLPQDGERALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N592</accession>
    <name>A0A0F7N592_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Agmatinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_10305</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arginase family. Agmatinase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015896.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_10305"/>
    <dbReference type="EnsemblBacteria" id="AKH82554">
        <property type="protein sequence ID" value="AKH82554"/>
        <property type="gene ID" value="AA958_10305"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_10305"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2172"/>
    <dbReference type="OrthoDB" id="1598732at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016813">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901564">
        <property type="term" value="P:organonitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005925">
        <property type="entry name" value="Agmatinase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020855">
        <property type="entry name" value="Ureohydrolase_Mn_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358">
        <property type="entry name" value="PTHR11358"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036979">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00116">
        <property type="entry name" value="ARGINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="SSF52768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01230">
        <property type="entry name" value="agmatinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01053">
        <property type="entry name" value="ARGINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH82554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="323" mass="34171" checksum="4D927FBDA7662B5A" modified="2015-07-22" version="1">MSSTGTPRGPVDSSRVPRYAGPATFARLPRLDEVGRTDVAVVGVPFDSGVSYRPGARFGGNAIREASRLLRPYNPAQDAAPFALAQVADAGDIAVNPFDIGEAVATVEGAADELLATGARLMTLGGDHTIALPLLRAVARRHGPVALLHFDAHLDTWDTYFGAAYTHGTPFRRAVEEGVVDTAALSHVGIRGPLYGRKDLDDDEKMGFGIVTSADVMRRGVDEVTDQLRQRIGDRPLYVSIDIDVLDPAHAPGTGTPEAGGLTSRELLEILRGLAGCRLVSADLVEVAPAYDHAEITSVAASHTAYELTTLMARQIAGERDAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5B0</accession>
    <name>A0A0F7N5B0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mandelate racemase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_14225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_027773297.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_14225"/>
    <dbReference type="EnsemblBacteria" id="AKH83196">
        <property type="protein sequence ID" value="AKH83196"/>
        <property type="gene ID" value="AA958_14225"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_14225"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2994"/>
    <dbReference type="OrthoDB" id="1825548at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034593">
        <property type="entry name" value="Mandelate_racemase_DgoD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013341">
        <property type="entry name" value="Mandelate_racemase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48080">
        <property type="entry name" value="PTHR48080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02746">
        <property type="entry name" value="MR_MLE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="SSF54826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MR_MLE" evidence="1">
        <location>
            <begin position="179"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="470" mass="51589" checksum="073F88C0A6A1C0D3" modified="2015-07-22" version="1">MQESENGSSLRSRRTALGLGAAAAAGGLGLGALAFRPAEEQVEFLTQKVSRASKPSKLKITDLRVAVLAGVPFTSPIVRIDTNQGISGWGEVRDDADKRYALELKGRLLGENPCNVEMLFKRLKQFGNHGRRGGGVSGVEMALWDLAGKAYGVPVFQMLGGAYRRKIRLYTDTTESEDPKVYAQRMKERVDMGFTFLKMDLGLEIVQDLPGAVVGKSLWDGNLQQYDGAPGGYGMTEHGLTMVQITDKGLDAMAEYVEAVRDAVGYDVPLGMDHFGHFDVNTAIRLANRFERYNLAWLEDLVPWFRTDDWKEITKAVNVPTMTGEDMYGLEAFRTLVDEGAVDLVQPDPATAGGILETKRIGDYAREQGMAMPLHYAGSPIGAMASAHIAAATENFVCLEYHASDVKFWNDLIAGGEPLLKDGFYHLTDAPGLGVELDEKVMAEHLAKGEKLFAPTKEWNNSPAWDRTWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5E0</accession>
    <name>A0A0F7N5E0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">MmcQ-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_07110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015377.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_07110"/>
    <dbReference type="EnsemblBacteria" id="AKH82027">
        <property type="protein sequence ID" value="AKH82027"/>
        <property type="gene ID" value="AA958_07110"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_07110"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1490"/>
    <dbReference type="OrthoDB" id="1817663at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007351">
        <property type="entry name" value="YjbR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038056">
        <property type="entry name" value="YjbR-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35145">
        <property type="entry name" value="PTHR35145"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04237">
        <property type="entry name" value="YjbR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142906">
        <property type="entry name" value="SSF142906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH82027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="130" mass="14436" checksum="A63B6E7E4B76AE59" modified="2015-07-22" version="1">MTPDQLRAACLEPNGAVEEWPFDRHQAISVFKVGGKMFALSELDATPLSVSLKCEPDLAVQLRAAHPEIVGGYHLNKRHWNTVRLDGAVPEGLVLEMIEDSYDLVVAKLPRAHRLTLDWPGERHRPPPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N648</accession>
    <name>A0A0F7N648_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Metallophos domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_08785</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015654.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH82307">
        <property type="protein sequence ID" value="AKH82307"/>
        <property type="gene ID" value="AA958_08785"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_08785"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1851"/>
    <dbReference type="OrthoDB" id="979842at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="2">
        <location>
            <begin position="311"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH82307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="678" mass="72879" checksum="8C7B86F78F987046" modified="2015-07-22" version="1">MSRFRPSRAYQPELDVRFPGDHVPGWARPLVEGQLPNSAAWLVELPRRAGKTWLAHAVERARAERLSLRVDLRSTAGAVRRSGLGCLTGGKQAPRVAPGCVVLVDEPAVARGAEDGARARTRNAPAAPGAPTRPAGGGVDPAALAAGLEQVREAGAVPVVFATPAEQLLLAPHLGADAPKDVLRPPRLADGECARMAGRAPEWAPVVVELLRAAEPAWLQTPFLLELALQTAEEHPALRTDAARLATAAYEEACGRHQYVPQWFHDGLAAEHRAALRARRWHDAGVEIAVRAAHTPPADDPVLARHLPDVLRIHHVTDLHHGGGLRANVDAKDTSQAGQRLAELAGAGSPLDAYLDHVRQLADQGRAPHLVIATGDLVNRPVDADGETALAWLRALEDLLAGHPDLRPGDPRVLLTGGNHDVSWELCLDDDPQARHRWFARIFAAYPHPDLHEPDTAARRVYVTYPDAGLRVALLGTAESGGEPAHDRDRERLERFRETYVAAADAADEDAVRRVVLEFERHDPGVIARGVLDRLTREPGYVTLAALHHPLSPVPAVEIAPYSGVVNAGQAKWTMAEAATSLVLHGHTHLGFTAAERLLGTARPWTTRIAGAPALGSRESDERNGYNEVFVAREGGDHALALRTVRYEAGTWTPGPTVGFTPGAPDETPLTLLCGDRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6B0</accession>
    <name>A0A0F7N6B0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GCN5 family acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_12330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_12330"/>
    <dbReference type="EnsemblBacteria" id="AKH82889">
        <property type="protein sequence ID" value="AKH82889"/>
        <property type="gene ID" value="AA958_12330"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_12330"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2591"/>
    <dbReference type="OrthoDB" id="1501005at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="192" mass="22352" checksum="2A80C7771D3A5BA3" modified="2015-07-22" version="1">MTLRPIRVRDQRAWREINQRNRDWLRPWEATLPPPPSGTPHTRRPTFRQMVRHLRSEASAGRMLPFVIEYEGTLCGQLTVAGITWGSMRSGHVGYWIDRDYAGRGVMPTSVALAVDHCFRTVGLHRIEVCIRPENMPSRRVVEKLGFREEGVRPRYLHIDGAWRDHLVFVLTAEEVPEGLVNRWRGLRHSEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6E1</accession>
    <name>A0A0F7N6E1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Neuraminidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_09215</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 33 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015723.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_09215"/>
    <dbReference type="EnsemblBacteria" id="AKH82377">
        <property type="protein sequence ID" value="AKH82377"/>
        <property type="gene ID" value="AA958_09215"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_09215"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1944"/>
    <dbReference type="OrthoDB" id="1293876at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004308">
        <property type="term" value="F:exo-alpha-sialidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00110">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006558">
        <property type="entry name" value="LamG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011040">
        <property type="entry name" value="Sialidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026856">
        <property type="entry name" value="Sialidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10628">
        <property type="entry name" value="PTHR10628"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13088">
        <property type="entry name" value="BNR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00282">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00560">
        <property type="entry name" value="LamGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50939">
        <property type="entry name" value="SSF50939"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="LamGL" evidence="5">
        <location>
            <begin position="412"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="LAM_G_DOMAIN" evidence="4">
        <location>
            <begin position="412"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="339"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="558"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH82377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="577" mass="61709" checksum="43BDD6D78D508D9F" modified="2015-07-22" version="1">MLFQAGTGGYFCYRIPAVVEAADGTLLAFAEGRVDSCADKGDIDIVLRRSTDGGATWSAPQVVLAGDGDTRGNPAPVVDRETGRISLLSTHNPGADDTVRTPYLQHSTDNGRTWSAARNMGAELSKPEWDRWYATGPGHGLQLTTGDHAGRLLVGGNHQGLDGRQGAHLLYSDDGGLTWQLGADDTRAVQPPDVKPQELSLFERRDGSVYAAARDERGTDPGNRAAAVSSDGGTTFDAPFATTPDLVSPVVQGATLRHGDQILASLPAHPADRKVMSVRASRDDGATWEPWQQGRVIHWGPTAYSDMAGLDGDRVGLLYEAGTAGPYETIRWARFNDAFLDQPNDDPPQPPAPAPGATTPDVSGSGNTAYVRGSSHLRPGRFGQSLYLDNAAPHIDARVEVPWNDSLDVGDGDFTWTGWFKYGRTNGAHAIMWAYGVGGNAPSVWLRAEPEQNRIIARMQMEQAAVSVQTTGAYNDNAFHFVTLQRAGGKLTLSVDGTSYAADAPPGSPTAGSEFGIGGIDVGQRLDGANRFHGYLDDMRVYDRALTRGELTAVRKDNAPVPRGQQLRLPLDTVTPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6N6</accession>
    <name>A0A0F7N6N6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_13095</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016341.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_13095"/>
    <dbReference type="EnsemblBacteria" id="AKH83009">
        <property type="protein sequence ID" value="AKH83009"/>
        <property type="gene ID" value="AA958_13095"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_13095"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2755"/>
    <dbReference type="OrthoDB" id="1692726at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH83009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="214" mass="23517" checksum="01F421F69C6935D8" modified="2015-07-22" version="1">MSRWMEALTIERGGFRIRVPESWWEFDVRPESRDDGIRQMVNDRVRRNPELAEQRGVLEAFLRKAAKDAWASGALYCGCMAESFGGDVPVTGSITVSLIGARTESGELLPTDPALIVGQIKQIRPKKEGDAWRKVSTVEIEGIGTAARTQGVEDVKIPGDDRTIRAVLMQTFIPVPGQEGKVALVAGSSQVLDLADSFFDVFDAITSTFRFVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6P4</accession>
    <name>A0A0F7N6P4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cysteine--tRNA ligase</fullName>
            <ecNumber evidence="11">6.1.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Cysteinyl-tRNA synthetase</fullName>
            <shortName evidence="11">CysRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">cysS</name>
        <name evidence="13" type="ORF">AA958_13445</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys)</text>
            <dbReference type="Rhea" id="RHEA:17773"/>
            <dbReference type="Rhea" id="RHEA-COMP:9661"/>
            <dbReference type="Rhea" id="RHEA-COMP:9679"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78517"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 11">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.16" evidence="11"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016399.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_13445"/>
    <dbReference type="EnsemblBacteria" id="AKH83068">
        <property type="protein sequence ID" value="AKH83068"/>
        <property type="gene ID" value="AA958_13445"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_13445"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2827"/>
    <dbReference type="OrthoDB" id="952207at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004817">
        <property type="term" value="F:cysteine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006423">
        <property type="term" value="P:cysteinyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00672">
        <property type="entry name" value="CysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00041">
        <property type="entry name" value="Cys_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015803">
        <property type="entry name" value="Cys-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015273">
        <property type="entry name" value="Cys-tRNA-synt_Ia_DALR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024909">
        <property type="entry name" value="Cys-tRNA/MSH_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032678">
        <property type="entry name" value="tRNA-synt_1_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890">
        <property type="entry name" value="PTHR10890"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09190">
        <property type="entry name" value="DALR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01406">
        <property type="entry name" value="tRNA-synt_1e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00983">
        <property type="entry name" value="TRNASYNTHCYS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00840">
        <property type="entry name" value="DALR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00435">
        <property type="entry name" value="cysS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11 13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="DALR_2" evidence="12">
        <location>
            <begin position="341"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="11">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="11">
        <location>
            <begin position="264"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AKH83068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="466" mass="51650" checksum="FBF8A7551E8BF6E8" modified="2015-07-22" version="1">MTIRLYDTSARQIRDFTPIVPGCVSIYLCGATVQAAPHIGHIRSGLDFDILRRWLLHRGYDVTFIRNVTDIDDKIISKSADQGRPWWAIGYENERAFNDGYEALGCLPPTYEPRATGHVPEMIEMMRALIDSGHAYAADGNVYFDVRSYPGYLALSNQELDNLRQPEGEGETGKRDQRDFAMWKAAKPGEPSWETPWGRGRPGWHLECSAMAHKYLGSRFDIHGGGIDLVFPHHENEIAQSKTFGDEFADYWLHNAWVTMSGEKMSKSLGNSVLISEMVKRWRPIVLRYYLGTPHYRSTIEYSEEALREAESAFARIEGFVQRVVEKAGGPVAPAADVPPAFAEAMDDDLGVPQALAVVHTTVRQGNAALSADDKEAAVARLAEVRAMLGVLGLDPLDPQWTGAGDAGRGADLHGAVDTLVRLVLEQREAARARKDYAAADAIRDQLQQSGLAIEDTPDGPRWTLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N719</accession>
    <name>A0A0F7N719_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA polymerase III subunit delta</fullName>
            <ecNumber evidence="5">2.7.7.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_14210</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.7.7" evidence="5"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_027773300.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_14210"/>
    <dbReference type="EnsemblBacteria" id="AKH83193">
        <property type="protein sequence ID" value="AKH83193"/>
        <property type="gene ID" value="AA958_14210"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_14210"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2991"/>
    <dbReference type="OrthoDB" id="1971388at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004622">
        <property type="entry name" value="DNA_pol_HolB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00678">
        <property type="entry name" value="holB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="1 5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="265"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH83193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="416" mass="43859" checksum="AE60C1FB2B07AFF3" modified="2015-07-22" version="1">MAVWDELIGQQRVAEQLAAAARAADARVTAEAGTAAAAAPGAHPADAAEPASASAMTHAWLFTGPPGAGRTTAARAFAAALQCVSPDRAAAGPGCGFCDGCHTALVGTHADVTVIATDLLTIGVKETRELVRRAQLAPSGGRWQVIVVEDADRLTEGAGNVLLKAIEEPAPRTVWLLCAPSVEDVLPTIRSRCRHLSLSTPAVEAVAAVLVRRDGITPAVAESAARAAGGHLDRARRLATDDRARERRSAVLRIPLRIDDIGGCLRSAQELVEVAADAAKEQAQELDEQETEEMRTALGAQPGGRMPRGTAGVMKDLQERQKRRSTRSQRDSLDLALTDLAGFYRDVLALQLGAVADVSLLPCADVGEGLRRIAESSTAETTLRRIDAIMECRDALERNVAPLLALEAMAVTLRKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N734</accession>
    <name>A0A0F7N734_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_14300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016525.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_14300"/>
    <dbReference type="EnsemblBacteria" id="AKH83208">
        <property type="protein sequence ID" value="AKH83208"/>
        <property type="gene ID" value="AA958_14300"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_14300"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3010"/>
    <dbReference type="OrthoDB" id="626968at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044260">
        <property type="term" value="P:cellular macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043412">
        <property type="term" value="P:macromolecule modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044238">
        <property type="term" value="P:primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007848">
        <property type="entry name" value="Small_mtfrase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05175">
        <property type="entry name" value="MTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MTS" evidence="1">
        <location>
            <begin position="188"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="527" mass="55474" checksum="0647E2C452EDE190" modified="2015-07-22" version="1">MVPVSATDDLSLPGPPLPDVPFPDSAAELRAALLAAGFTADGLLDLLGAPAYAALARSETVPAERATRWPPGRTPPALATLTRLFLLQHAVPREHAEAVLPLSACLTDGWVREDGEAVRAVVDVRPYSGPEGQDWWIVSDLGCAVGGAAGARRAGAYGTGAPGSSRADLVLGVGGASTTLAGLTVPLDGGRVLDVGTGSGIQALHAGARAGAVTATDVNPRALDCARLTLALSGAPAADLRAGSLFEPVAGERYDLIVSNPPFVISPAARLTYRDGGMAGDELCRTLVAGAAEHLAEGGYCQLLANWQHVEDEDWRERVAGWVPPGCDAWIVQREVQDVTQYAELWLRDAGDHADPAAYAARYDDWLDAFAASRTRAVGFGWITLRRTDAADPVVTVEDWPHAVEQPLGAAVVEHFARQDFLRRTDDAALLATVFRLADDVVQEQVGRPGEEDPEHVVFRRELGMRRATRVDTVSAGFAGACDGTLSAGVILDAIAQVLAADPAALRERTPEMIRLLVEQGFLAPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N799</accession>
    <name>A0A0F7N799_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_14745</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016588.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH83273">
        <property type="protein sequence ID" value="AKH83273"/>
        <property type="gene ID" value="AA958_14745"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_14745"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3105"/>
    <dbReference type="OrthoDB" id="1880721at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH83273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="90" mass="9758" checksum="5FBFB5B6EE45153D" modified="2015-07-22" version="1">MYSQDAISGRRSGRSAPTDEMIWGLACVICGTDYRHAPAANARVVSHRDDKQLLACQGVCARMASGSVTGVDETPVPLAERMRRYGTDRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7A3</accession>
    <name>A0A0F7N7A3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PPM-type phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_11130</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016030.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_11130"/>
    <dbReference type="EnsemblBacteria" id="AKH82692">
        <property type="protein sequence ID" value="AKH82692"/>
        <property type="gene ID" value="AA958_11130"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_11130"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2344"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="PPM-type phosphatase" evidence="3">
        <location>
            <begin position="152"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH82692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="382" mass="40223" checksum="F98D611DD80C90D2" modified="2015-07-22" version="1">MRLPLRGGHRRDVGGAEDPAAPGASTMPRVLFPLLIIAITIVIDIATPSTAQVAPLLVAAPVVAAATLSVRTTAAFSAVVLGLTVALNVYHDVWGQLSSDMTLASACAVGIASIVGAAIRQQRETELRQVRSVAGAAQRALLRPLPPRIDRLALHSVYLAAEAEAQIGGDLYEALPTPYGARVLIGDVRGKGLPAVGVSAVLTGCFREAAYREPTIGEVAGRLEETALREIARDDPSEAYSERFTTALLVEIPPDEPVARIVHLGHPEPLLIDGATVTSHMPDRPGLPIGLGGLVGTLPVPQTIAFRPGERLLLYTDGFIEARNENGVYFPLAASVARHAEGALADLVTALRRDLLRHAGRQLADDAALVVIERLPSTPPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7I2</accession>
    <name>A0A0F7N7I2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD-dependent epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_22835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017822.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH84565">
        <property type="protein sequence ID" value="AKH84565"/>
        <property type="gene ID" value="AA958_22835"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_22835"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4809"/>
    <dbReference type="OrthoDB" id="1928091at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="304" mass="32285" checksum="B109428924DCD9A8" modified="2015-07-22" version="1">MSLAVVVGAGGTGVATARLLADAGHRVRLVTRGGGGPEHPAIERVAADAADADRLSEVARGAATLFNCAAPPYHTWPKALPPLAEGLLTAAERTGADYVMLDNLYAYGPVEGPMTEDLPLAPSSVKGRVRAEVWRQADAAHEAGRVRVTTVRASDFIGAGAYSVITVTVAPKVLAGKPAPVPADLDAPHSWTATRDAARALVAVAQDERAWGRVWHAPTAAPLSVRELAARLARLAEVREPRLRAMPAWLLRAGGLFSPVVRELPEMQYQFQQPFVLDSSRIEETFGLHPTPLDDVLREMIAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7L9</accession>
    <name>A0A0F7N7L9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA primase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_15545</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016700.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH83388">
        <property type="protein sequence ID" value="AKH83388"/>
        <property type="gene ID" value="AA958_15545"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_15545"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3272"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025711">
        <property type="entry name" value="PepSY"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03413">
        <property type="entry name" value="PepSY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519211" evidence="2">
        <location>
            <begin position="26"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="PepSY" evidence="3">
        <location>
            <begin position="83"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH83388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="177" mass="18085" checksum="95D189959CE1E8E0" modified="2015-07-22" version="1">MKRNIVIAAVASAALITGGTVTAVAASDGGDSGADAASVPADVQVAGDDRDDGQDDRDDRDDRDDDGRDDDRAEAEALAAASVSVDDAIAAALREHAGTVGSAEFDAADDEGKNEASKWEIDVLGEDGKWYEVNVDAASGDVVADRGDDDGQSDDGDDDSDDRGDDSGDDDSDDSDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7Q7</accession>
    <name>A0A0F7N7Q7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-lactamase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_15805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016741.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_15805"/>
    <dbReference type="EnsemblBacteria" id="AKH83429">
        <property type="protein sequence ID" value="AKH83429"/>
        <property type="gene ID" value="AA958_15805"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_15805"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3331"/>
    <dbReference type="OrthoDB" id="537440at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase" evidence="1">
        <location>
            <begin position="21"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="456" mass="49057" checksum="33B24CC3D7014352" modified="2015-07-22" version="1">MPPYDDALLPATARALRHRLAVAQREGRTPSLVAAVVRDGETVWSGARSMVDGHEPTTDTQYRVGSLTKTFVAVLVLRLRDEGLLDLADPLGKHVPGTQAPAVTIAQLLSHSSGIGAEPRGPWWERTPGTLRPELGALFDGDPTRHPAGRRYHYSNPGFAYLGAVVEALRGAPWDDVLRRELLEPLDLRRTTPLPEAPHAGGFAVHPWADVMQPEPLHDTGRMAPAGQLWSTAGDLARFAAFLVRGDDRVLCAGTLAEMRTPAVAPEAASWDSGYGLGMQLIRRDGTVLAGHTGSMPGFLACLLSDVDEDVSAVVLTNVTSGVSVSGLAADLIGTVLRHEPRIPEPWRPLAADAVDPELLALTGPWYWGANPHVLRLKEDRWLDLGPLTGNGYASRLRPEADGTWTAVDGYCAGETLRVERAADGEVSHLDLGTFVFTREPYDPDAPVPGGTRGWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7U3</accession>
    <name>A0A0F7N7U3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADPH:quinone oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_16260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016809.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_16260"/>
    <dbReference type="EnsemblBacteria" id="AKH83503">
        <property type="protein sequence ID" value="AKH83503"/>
        <property type="gene ID" value="AA958_16260"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_16260"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3425"/>
    <dbReference type="OrthoDB" id="1752728at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="15"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="342" mass="35806" checksum="EA7AD0799E79C1AD" modified="2015-07-22" version="1">MSTSMRVMELVRFGGADTAFATRELPRPTPGPGQVLVRVMATSVNPLDLQTRRGDYRDQVALPAVIGNDVSGVVAGTGPGADDFRQGDEVWYLAPVFAGQGTYAEFHVVDQALVARKPARLSHVEAAGLALVGVTVWEALVERAGLRAGERVLVHGGAGGAGSVAVQVASALGAEVVTTARARDHEFVTELGADLAIDFSTGDYVPQVRAMGGVDVVLDTVGGDTLTRSPEVLADRGRVVSIVDNSEPQNLLAAWGVNATYHFVFVSPGRAKLEALGRLVDQGELRPVIGAVLPLADIAQAHTLLEGGSTSEGRRRPRGKIAIAVRPLDQPPHGTGPLARKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7X3</accession>
    <name>A0A0F7N7X3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">5-formyltetrahydrofolate cyclo-ligase</fullName>
            <ecNumber evidence="3">6.3.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_12355</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>(6S)-5-formyl-5,6,7,8-tetrahydrofolate + ATP = 5,10-methenyltetrahydrofolate + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10488"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="ChEBI" id="CHEBI:57457"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.</text>
    </comment>
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    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
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    <dbReference type="EnsemblBacteria" id="AKH82892">
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        <property type="entry name" value="FTHF_cligase-like_sf"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
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    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="156"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="8"/>
            <end position="12"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
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    <feature type="binding site" evidence="2">
        <location>
            <position position="54"/>
        </location>
        <ligand>
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        <location>
            <position position="59"/>
        </location>
        <ligand>
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        <location>
            <begin position="137"/>
            <end position="145"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010638"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR006806-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH82892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="225" mass="22724" checksum="03345DF15D922412" modified="2015-07-22" version="1">MGSDQARKAALRRTLLAARAAVPPGEAEVAARRLARRALELPELAGARTVAAYVSVGREPGTRELLEALRARGTAVLLPVLLADDDLDWAEYGGPGALRPAGRGLLEPAGPRLGTEAVRAADAVLLPGLAVDGRGLRLGRGGGSYDRVLARLAGGAGGGGAGGVSPRRTGAETGAPPADAPSAAGPALVVLLYDGEVLDHVPAEPHDRPVTAAVTPSAVHRFPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8B9</accession>
    <name>A0A0F7N8B9_9ACTN</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_17300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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    </dbReference>
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    </dbReference>
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            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
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            <begin position="30"/>
            <end position="372"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="372" mass="40099" checksum="9F561639CA9868E0" modified="2015-07-22" version="1">MRPRLRAISTVVVPGVAIALALLGGSAAAASDQDGQGQNGRPGAAGRTVEVRVGTYNVCGHGCLPTKAECERVIGRDCATKLRPWAEGRAADVAADIDAAGLGVVATQEIGNNATPSQPAVDVESFRAPLTAALQEYGYAEAPADYAGTRHPEKGYPLKSGAGRYTYYDASRYSHLDKRGRELPHDLLWLPDSTEIYGKTMTWNVLREKSSGARFVVVDMHLEYRKNGATDPNGWTKNWDEVRYADARRTAEELTLRNKHTRNLPIVFAGDMNSGSAAEGASAIDAFSDVGFTDALAVADRVTGDAYASYNGGKIPLPLGEKIDHLFVRNGTKVSEWVQIPQTTATEGPQAELLRSDHNLSYATVRLMKGHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8H0</accession>
    <name>A0A0F7N8H0_9ACTN</name>
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            <fullName evidence="2">HTH luxR-type domain-containing protein</fullName>
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        </lineage>
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        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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    <dbReference type="EnsemblBacteria" id="AKH83724">
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        <property type="gene ID" value="AA958_17625"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_17625"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3710"/>
    <dbReference type="OrthoDB" id="1036370at2"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="260"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH83724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="326" mass="35745" checksum="755DE343D93F4B01" modified="2015-07-22" version="1">MHAGHDHEHGHSLQEPCPAAREAYTVAVRDGRIAAADARSAPCLSDLALLSPDPDDPDWLLPVPAADAMMGLLVSREREIRERQQHAADLAKSFSRFIDIGIEVASDNSPITVLEGLGTINTALDLAVGECSYELLTIQPEAATRGARALGEALQRVRPLAERGVRMRTLYQHAAREAPMTLAYLRFVGPQQVEVRTLEEIIERLIIVDRQAAFLPARPDRQVALELRHPGLVSYLVGVFEQFWQLATPLEEAAYTDATHEGITGVQRSIARLLVEGHLDQNIARRLGMNVRTCRAHIAKLASALGSNSRAQLGYLIARSGILDET</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8P1</accession>
    <name>A0A0F7N8P1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Sulfurtransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_13640</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>hydrogen cyanide + thiosulfate = 2 H(+) + sulfite + thiocyanate</text>
            <dbReference type="Rhea" id="RHEA:16881"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:18022"/>
            <dbReference type="ChEBI" id="CHEBI:18407"/>
            <dbReference type="ChEBI" id="CHEBI:33542"/>
            <dbReference type="EC" id="2.8.1.1"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016432.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_13640"/>
    <dbReference type="EnsemblBacteria" id="AKH83102">
        <property type="protein sequence ID" value="AKH83102"/>
        <property type="gene ID" value="AA958_13640"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_13640"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2871"/>
    <dbReference type="OrthoDB" id="1385159at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001307">
        <property type="entry name" value="Thiosulphate_STrfase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00683">
        <property type="entry name" value="RHODANESE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rhodanese" evidence="4">
        <location>
            <begin position="19"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="4">
        <location>
            <begin position="155"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="181"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH83102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="280" mass="31572" checksum="370F8EE1DB54CA5D" modified="2015-07-22" version="1">MSRRSDVLVDADWVEANLDNPKVVLVEVDEDTAAYDKNHIKNAVRIDWKTDLQDPVRRDFVDQAGFEKLLSERGIANDDTVVLYGGNNNWFAAYAYWYFKLYGHEDVKLLDGGRKKWELDSRDLVAEVPQRAATAYRAKPQDTAIRAFRDDVVAAIGTLNLVDVRSPDEFSGKLLAPAHLPQEQSQRPGHVPSARNIPWSKSANDDGTFRSDEELKELYEGEGVDLSKDTIAYCRIGERSAHTWFVLHELLGQENVKNYDGSWTEYGSLVGVPIELGAND</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8R7</accession>
    <name>A0A0F7N8R7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_22110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017703.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_22110"/>
    <dbReference type="EnsemblBacteria" id="AKH84441">
        <property type="protein sequence ID" value="AKH84441"/>
        <property type="gene ID" value="AA958_22110"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_22110"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4657"/>
    <dbReference type="OrthoDB" id="931964at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH84441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="304" mass="32068" checksum="2D2B7C376C4BB09B" modified="2015-07-22" version="1">MLGIVVKTERGERHVRVSAAELAGLVGRIGGAGDHFLMLQRIPDLPGVFAQVWHDAGGGYEVEHGDGGADRHFAATAEGPGAVIAALTGWAREEAGWAEGLSWSRADTTPAPAVPPLDLGEEERQELERRVREVLAAGYATRAELAECAEEFLVTGDRRPVSGPQAGALADRLWLERVAEQSGRRGETDPERLTRAFATLREAGITAREHFACCRSCGNAEIGGAGEPDARGFVYSSHQSSESAADGGLTLYCGGFDGSSGTTAAIGHEVVAALGDAGLRTEWDGDPGRSITVTGLDWRRRLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8S5</accession>
    <name>A0A0F7N8S5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Phosphomannomutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AA958_22170</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNQ-509</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017712.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_22170"/>
    <dbReference type="EnsemblBacteria" id="AKH84451">
        <property type="protein sequence ID" value="AKH84451"/>
        <property type="gene ID" value="AA958_22170"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_22170"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4669"/>
    <dbReference type="OrthoDB" id="637615at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016868">
        <property type="term" value="F:intramolecular transferase activity, phosphotransferases"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="SSF55957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGM_PMM_I" evidence="8">
        <location>
            <begin position="56"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_II" evidence="9">
        <location>
            <begin position="215"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_III" evidence="10">
        <location>
            <begin position="334"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_IV" evidence="7">
        <location>
            <begin position="517"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AKH84451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="571" mass="58130" checksum="36FEE62B16198B74" modified="2015-07-22" version="1">MTTNPTADAAGDAAALTARAGAWLAEDPDPDTRAELAALLRDGDTAALADRFAGTLQFGTAGLRGELGAGPMRMNRAVVIRAAAGLAAYLDEQGAGGGLVIVGYDARHKSHAFAEDTAAVMTGAGFRAAVLPRPLPTPVLAFAIRHLGAVAGVTVTASHNPPRDNGYKVYLGGGSQIVPPADAGIAEAIAAVGPLADVPRPAGGWEVLGEEVVEAYLDRAAAVVTPGGPRAVRTVHTALHGVGGTVLAAAFTRAGFPAPVPVAAQAEPDPDFPTVAFPNPEEPGAMDLAFATARAAADGDVDVIIANDPDADRCAVAVPDAAADGGAGWRMLRGDEVGALLATHLVRKGAAGTFAASIVSSSLMGRIARAAGLPYEETLTGFKWLARVDGLRYAYEEALGYCVDPAGVRDKDGITAALLVAELTAELKAAGRTLRDLLDDIAVEHGLHATDQLSVRVDDLDVIATAMRRLRTAPPRSAAGLRVTRAEDLSKGTPALPPTDGLRYTLGGDEARGVAAARVIVRPSGTEPKLKCYLEAVIPVPAGLPGLPAARATAAEVLADLKADLSTAAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8T0</accession>
    <name>A0A0F7N8T0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_18810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017205.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH83908">
        <property type="protein sequence ID" value="AKH83908"/>
        <property type="gene ID" value="AA958_18810"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_18810"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3950"/>
    <dbReference type="OrthoDB" id="792957at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="336" mass="36439" checksum="B8777894466CDEAF" modified="2015-07-22" version="1">MLPHTAGFIDQARTALDMMPPANHLDDWRLLLDDLEHAATECRRILDIEPVASDEKARRAQDAALWPYVTTWAEHGYLVDSLINQLHPVAPAPVPSDTEQRRLTQQVHDARSHGRLDIVRTWWDTAGRLISLVRIEGRNPLLALAGDLDSPGLEILGRFDDEDEAIGACPPAAPAGVLRPDVSSADTIPPIQTTVPGLTRWVIEARVGVDVGIALLAVTHPEDAALPAVRTLLDTAREYAAATQTRQGAHLAARLEGLSSRLHALGRELHQVGHEMMNANAVLPPHRTPQPRHLPPQRDDDRPHPGPANAHHLSAPAAPPGPVSDAGPAPGTRRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8U0</accession>
    <name>A0A0F7N8U0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_13955</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016485.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_13955"/>
    <dbReference type="EnsemblBacteria" id="AKH83157">
        <property type="protein sequence ID" value="AKH83157"/>
        <property type="gene ID" value="AA958_13955"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_13955"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2937"/>
    <dbReference type="OrthoDB" id="1108236at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="23"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="177"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="212"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="241"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="279"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="309"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="344"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="368"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="404"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="451"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="24"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH83157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="486" mass="48811" checksum="CBC8FB0A7E7952BC" modified="2015-07-22" version="1">MSVLDKAAAPPAPALRMTGRQKLVLTLLLGAQFMVAVDFSILNVALPVIGAGLGFPLAHLQWIATAFALAAAGFTLLFGRIADLFGRKRLFLGGMALLGLSSVLGGLATSPGMLLVARVLQGLATAAVTPAGLSLLTTAFPEGPLRQRALGLNGALMSAGFTAGAVLGGFLTDLLSWRWAFLVNVPVTAAILAVAPAVIADSRPAGRPRLDLPGAVTVTGGLLAVVYGLTHAGEAGWTEPVTLAALGAGAALLTAFWFVEKRAEKPLVPVRILRRPTVVWGNAAGLVAFLTETSLVFLLTLYLQEVLGYTPLATGLAFGVLGLGTVLGGTLGGRVVGRVGSRAAIVYGGAAQAAATAALLALGTSGGWIWLLLAATFAGGVGNMLMIVGFMVTATSGLPDSEQGLATGLATMTQQVGITMGIPVMSAIATARITAADGTGPEAVLDGVRTAVGVNAALVLAGALAAGALLGRRRRAAPGTPGTPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N951</accession>
    <name>A0A0F7N951_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_22770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017813.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH84556">
        <property type="protein sequence ID" value="AKH84556"/>
        <property type="gene ID" value="AA958_22770"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_22770"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4793"/>
    <dbReference type="OrthoDB" id="1795334at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH84556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="123" mass="13322" checksum="7BC58D5CEFCE4364" modified="2015-07-22" version="1">MERVIDLDEAVAAVADRWPAWLAAGLIAEPQTWRDEADAWPQQLKTDRSRVNDPDSVGIHLHGPDEAELLVVLYRGGWADVDYCTDADDAGVIPAPEVGSAQAFASLLDACITRVFGISYDVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9D9</accession>
    <name>A0A0F7N9D9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribosome maturation factor RimP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rimP</name>
        <name evidence="6" type="ORF">AA958_26290</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for maturation of 30S ribosomal subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RimP family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018396.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_26290"/>
    <dbReference type="EnsemblBacteria" id="AKH85155">
        <property type="protein sequence ID" value="AKH85155"/>
        <property type="gene ID" value="AA958_26290"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_26290"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5535"/>
    <dbReference type="OrthoDB" id="1595498at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01734">
        <property type="entry name" value="YlxS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01077">
        <property type="entry name" value="RimP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003728">
        <property type="entry name" value="Ribosome_maturation_RimP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028998">
        <property type="entry name" value="RimP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036847">
        <property type="entry name" value="RimP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028989">
        <property type="entry name" value="RimP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035956">
        <property type="entry name" value="RimP_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33867">
        <property type="entry name" value="PTHR33867"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02576">
        <property type="entry name" value="DUF150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17384">
        <property type="entry name" value="DUF150_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74942">
        <property type="entry name" value="SSF74942"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75420">
        <property type="entry name" value="SSF75420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="DUF150" evidence="4">
        <location>
            <begin position="12"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="DUF150_C" evidence="5">
        <location>
            <begin position="88"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH85155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="166" mass="18371" checksum="E044735FCA3E65D7" modified="2015-07-22" version="1">MSTTQNERLRDLLEPLVKERDLDLEEIALTPAGRRRVLRVVVDADGGVGLDTCADLSRRIAEELDAADAMGDRPYVLEVTSPGTDRPLTLPRHYRRAADRLVKVQLREGGEVVGRITAVDDAGLDLEVPGVKGRKPTARRLEFGEIATARVEIEFNRKVTKDEEGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9H4</accession>
    <name>A0A0F7N9H4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UPF0182 protein AA958_23535</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_23535</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the UPF0182 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_23535"/>
    <dbReference type="EnsemblBacteria" id="AKH84686">
        <property type="protein sequence ID" value="AKH84686"/>
        <property type="gene ID" value="AA958_23535"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_23535"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4963"/>
    <dbReference type="OrthoDB" id="170146at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01600">
        <property type="entry name" value="UPF0182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005372">
        <property type="entry name" value="UPF0182"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39344">
        <property type="entry name" value="PTHR39344"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03699">
        <property type="entry name" value="UPF0182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="150"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="185"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="435"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="857"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="436"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="904"/>
            <end position="920"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH84686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="969" mass="106268" checksum="3597FA1849BFCD61" modified="2015-07-22" version="1">MTLGALAILGIIFVMFAGFWTDWLWYRSVGYSSVFTTRLWTKVGLFFVFGLLMAFAVGFNIWLAHRLRPPLSAMSLEQESLDRYRMNLAPYKKWVLLGIATLVGLIAGASATGQWRTWLLWVNGQSFGEKDPQFHKDISFFAFDLPWYRFLLGFGFATVVLCTIAAALTHYLYGGLRISSPGARATSAATGHLAVLLGTFVALKAVAYWFDRYSLATKTSGLKTTDGWTGLRYVDANAYLPAKTILFVIAIICAVLFFATLWRRTWQLPLIGLGLMVLSAILIGGLYPAIVQKFQVQPNEQAKETPFIKKNIDATRKAYDIDGSQVTEYSGQAPKDITNEQLRSAVDSTASVRLLDPSVVSPTYQQQQQVRGYYQFPGTLDVDRYEDEDGDSQDTVVGLREINVNGIPEKGWINSHFRYTHGYGVVAAKGTEVTEDGDPAYTEKDLPPEGELGDYEPRIYYGEQTRDYSIVGGPQDEVDYADESGEKTYRYKGDSGVDLSNPINRAAYALTFSEPQIMYSGAIGDGSQIIYNRTPKERVEAVAPWLTIDGDPYPAVVDGRITWIVDAYTTSNGYPYSTRTTLGDTTADSLTDDQRSVVAQQNQVNYIRNSVKATVDAYDGSVDLYEWDTEDPVLKTWMKAFPDTVKPRGEISDALMDHLRYPQDLFKVQRELLTQYHVTGSKQFYSGSEQWEIPDDPTTKVESSVPPYYLSMKMPDQDSRSFSLTTTFTPRNRNNLGAYMAVGADARSDDFGQIRILKLPPNSPVPGPKLVQSRFNSNATIADQINILQRGDSEVIYGNLLTVPLEGGLIYIEPVYVQGTGTGYPLLRKVLVTYGDQTAFEDTLPKALNVVFGVEEATPPEDTGEEPPPEEPPPAGGSLQDAVEDAQKAYEDGQQALQDQDWEAYGKAQDDLEEALQRIEDAEQQAGANGDGAGEGAGKGAGDGGADGAGDGGGGSDAGDAGDGGGSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9I3</accession>
    <name>A0A0F7N9I3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Diaminopimelate epimerase</fullName>
            <shortName evidence="8">DAP epimerase</shortName>
            <ecNumber evidence="4 8">5.1.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">PLP-independent amino acid racemase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">dapF</name>
        <name evidence="10" type="ORF">AA958_26580</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>(2S,6S)-2,6-diaminoheptanedioate = meso-2,6-diaminoheptanedioate</text>
            <dbReference type="Rhea" id="RHEA:15393"/>
            <dbReference type="ChEBI" id="CHEBI:57609"/>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
            <dbReference type="EC" id="5.1.1.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; DL-2,6-diaminopimelate from LL-2,6-diaminopimelate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the diaminopimelate epimerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="5.1.1.7" evidence="4 8"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018442.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_26580"/>
    <dbReference type="EnsemblBacteria" id="AKH85205">
        <property type="protein sequence ID" value="AKH85205"/>
        <property type="gene ID" value="AA958_26580"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_26580"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5593"/>
    <dbReference type="OrthoDB" id="1921631at2"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008837">
        <property type="term" value="F:diaminopimelate epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00197">
        <property type="entry name" value="DAP_epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018510">
        <property type="entry name" value="DAP_epimerase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001653">
        <property type="entry name" value="DAP_epimerase_DapF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31689">
        <property type="entry name" value="PTHR31689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01678">
        <property type="entry name" value="DAP_epimerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00652">
        <property type="entry name" value="DapF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01326">
        <property type="entry name" value="DAP_EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 8" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="87"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="213"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="223"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="222"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Could be important to modulate the pK values of the two catalytic cysteine residues" evidence="8">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <feature type="site" description="Could be important to modulate the pK values of the two catalytic cysteine residues" evidence="8">
        <location>
            <position position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AKH85205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="288" mass="29939" checksum="E3393CE2102FD58F" modified="2015-07-22" version="1">MSTARLHFLKGHGTENDFVIVPDPAGLIDLSPAAVARLCDRRAGIGGDGLLRVVRSDAHPEGRRMAADAEWFMDYRNADGSVAEMCGNGVRVFARYLQHAGLVESGDLAVGTRAGVRRVHLAKDGDITVGMGRAALAAGPDAEVTVTVGERSWPARNVGMGNPHAVAFVADLADAGRLYEAPGVAPASAYPQGVNVEFVVDRGPRHVAMRVHERGSGETRSCGTGACAVAVAAARRDGVDPAATGRPETYTVDVPGGRLVVTEQPDGEVEMTGPALIVAEGDTAAGWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NA22</accession>
    <name>A0A0F7NA22_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_16575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016862.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_16575"/>
    <dbReference type="EnsemblBacteria" id="AKH83557">
        <property type="protein sequence ID" value="AKH83557"/>
        <property type="gene ID" value="AA958_16575"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_16575"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3488"/>
    <dbReference type="OrthoDB" id="1354855at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519231" evidence="1">
        <location>
            <begin position="37"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="251" mass="25807" checksum="099EB91DFC5ED42B" modified="2015-07-22" version="1">MKKNWNRRSYGTGAARVAATALAALLAALTTGAAPAAADPAAEATAAEAAPPGAAFDFGACPAADELPAGADPGTWRCEVMHATGRLRVGGVDEPVERPMTLTFAEGRVDGAYAQVFGEMTAEPIRVGGTPLTLTPRYGGYSDFEADDVRRGELDLTLAVGGPLLPKGCSIGPAASEPIHLVLKDTRPTEVISEDPLVVSFAAADREFTAPRTEGCGRPGGRILDRVLGLPAPAGENSLELDATVAIKPYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAB6</accession>
    <name>A0A0F7NAB6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulatory protein AfsQ1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_22125</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_22125"/>
    <dbReference type="EnsemblBacteria" id="AKH84443">
        <property type="protein sequence ID" value="AKH84443"/>
        <property type="gene ID" value="AA958_22125"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_22125"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4660"/>
    <dbReference type="OrthoDB" id="817710at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="6"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="127"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="127"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH84443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="228" mass="25435" checksum="1CB538EF0E44A220" modified="2015-07-22" version="1">MTRVPSLLLIEDDDAIRTALEMSLSRQGHRVTTAATGEDGLKLLREQRPDLIVLDVMLPGIDGFEVCRRIRRTDQLPIILLTARSDDIDVVVGLESGADDYVVKPVQGRVLDARIRAVLRRGERETTDSATFGNVVIDRSAMTVTKDGEHLQLTPTELRLLLELSRRPGQALSRQQLLQLVWEHDYLGDSRLVDACVQRLRAKVEDVPSAPTLIKTVRGVGYRLDPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAF3</accession>
    <name>A0A0F7NAF3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-dehydro-3-deoxyphosphogluconate aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_28475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the KHG/KDPG aldolase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018759.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_28475"/>
    <dbReference type="EnsemblBacteria" id="AKH85525">
        <property type="protein sequence ID" value="AKH85525"/>
        <property type="gene ID" value="AA958_28475"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_28475"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6000"/>
    <dbReference type="OrthoDB" id="1497385at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00452">
        <property type="entry name" value="KDPG_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000887">
        <property type="entry name" value="Aldlse_KDPG_KHG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30246">
        <property type="entry name" value="PTHR30246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01081">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="206" mass="21149" checksum="99AF420856BF5EEF" modified="2015-07-22" version="1">MYRWEITRAALEQRVVAIVRSDTYDGAAATADSLLSAGISSLEISLTTPFALELVSSLRREAGTEAVIGAGTVLDAASARLAVDAGARYLVAPNLDAGVVATAHRYGIPVFAGVATPTEMVRALELGVDVMKLFPASAHEPGWVKDVRAALPQAAVLPTGGISIAEAPDWIAAGAVAVGMGSALSGGDREEVAKRATDLLSRLTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAK3</accession>
    <name>A0A0F7NAK3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7 8">Transcription elongation factor GreA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Transcript cleavage factor GreA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">greA</name>
        <name evidence="12" type="ORF">AA958_22375</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7 8">Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the GreA/GreB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_027771611.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_22375"/>
    <dbReference type="EnsemblBacteria" id="AKH84489">
        <property type="protein sequence ID" value="AKH84489"/>
        <property type="gene ID" value="AA958_22375"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_22375"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4711"/>
    <dbReference type="OrthoDB" id="1536415at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070063">
        <property type="term" value="F:RNA polymerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032784">
        <property type="term" value="P:regulation of DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00105">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036953">
        <property type="entry name" value="GreA/GreB_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018151">
        <property type="entry name" value="TF_GreA/GreB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006359">
        <property type="entry name" value="Tscrpt_elong_fac_GreA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028624">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001437">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023459">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022691">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036805">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30437">
        <property type="entry name" value="PTHR30437"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01272">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03449">
        <property type="entry name" value="GreA_GreB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006092">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46557">
        <property type="entry name" value="SSF46557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01462">
        <property type="entry name" value="greA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00829">
        <property type="entry name" value="GREAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="12" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="GreA_GreB_N" evidence="11">
        <location>
            <begin position="10"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="GreA_GreB" evidence="10">
        <location>
            <begin position="86"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AKH84489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="165" mass="17900" checksum="C2DBEE3912DC7EAC" modified="2015-07-22" version="1">MTQTSDNVTWLTQAAYDQLKAELEHLSGPARTEIAKKIEAAREEGDLRENGGYHAAKEEQGKQELRVRQLQQLLENAKVGEAPPDDGVVEPGMVVTIAFDGDESDTLTFLMASREYASGDVETYSPQSPLGMGVNGKKVGEEASYELPNGKKAMVTILNAKPYAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAN9</accession>
    <name>A0A0F7NAN9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_22590</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017782.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_22590"/>
    <dbReference type="EnsemblBacteria" id="AKH84524">
        <property type="protein sequence ID" value="AKH84524"/>
        <property type="gene ID" value="AA958_22590"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_22590"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4753"/>
    <dbReference type="OrthoDB" id="445854at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003714">
        <property type="entry name" value="PhoH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02562">
        <property type="entry name" value="PhoH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13638">
        <property type="entry name" value="PIN_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1277">Toxin-antitoxin system</keyword>
    <feature type="domain" description="PINc" evidence="6">
        <location>
            <begin position="10"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH84524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="437" mass="47890" checksum="88BBCF154B690919" modified="2015-07-22" version="1">MVNSKKPDRRTYVLDTSVLLADPMAMARFDEHEVVLPVVVVTELEAKRHHPELGYFARQALRQLDEFRIRYGRLDAPIPLGDLGGTLRVELNHTDIGVLPAGFRLGDNDSRILAVARNLQAEGQDVTVVSKDLPLRIKASSVGLAAEEYRAELAITDSGWTGMAELMLSGEQVDELFAAEVVSVPEADDLPVHTGLVLQSERGRALGRVTPDGRVRLVRGDREVFGIHGRSAEQRIALDLLVDEDVGIVSMGGRAGTGKSALALCAGLESVLERRQHQKVMVFRPLYAVGGQELGYLPGTEAEKMSPWAQAVFDTLSAVTSREVIEEVIARGMLEVLPLTHIRGRSLHDAFVIVDEAQSLERNVLLTVLSRIGTNSRVVLTHDVAQRDNLRVGRYDGVVAVVEKLKGHPLFAHVTLNRSERSPIAALVTEMLEEGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAR3</accession>
    <name>A0A0F7NAR3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcriptional regulator, SARP family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_22930</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AfsR/DnrI/RedD regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017840.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_22930"/>
    <dbReference type="EnsemblBacteria" id="AKH84583">
        <property type="protein sequence ID" value="AKH84583"/>
        <property type="gene ID" value="AA958_22930"/>
    </dbReference>
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        <property type="term" value="P:phosphorelay signal transduction system"/>
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        <property type="term" value="P:regulation of transcription, DNA-templated"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="Gene3D" id="3.40.50.300">
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        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
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    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
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    <dbReference type="InterPro" id="IPR041617">
        <property type="entry name" value="TPR_MalT"/>
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        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00486">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="OMPR_PHOB"/>
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    </dbReference>
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    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="92"/>
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    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
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            <begin position="1"/>
            <end position="92"/>
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        <location>
            <begin position="1027"/>
            <end position="1055"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH84583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="1055" mass="112885" checksum="E46689BF7E983252" modified="2015-07-22" version="1">MEFHLLGPIEAAAADGRPVDLGPARQRSVLAALLLDGGRAVPTAQLVHRVWGHAAPQRATETLYSYLSRLRRTLAGSQATLHRSPDGYELAVGPAGSVDVHRFRLLLTRARAATTTTDAAAAGLFREALALWRGLPFPGVDTPWFNGVRDALAKELFAAELDSADVRLRLGDHAALLTGLAARSAAHPLDERLAAQYMTALYRCGRPADALDHYRRIRRLLAEELGIDPGRPLQQVHQAVLGGDPELSVPEPAGAAPVRRPESAPPAWLAQCQLPPDVRGFAGRTDLVARLAELLECRDAAPVVVSGSPGVGKSALAVHLGHRLRRAFPDGQWYVRLQGTRERPRDPADVLAALLRASGEDAAAIPESLEDRAGAFRGRAADRRVLLVLDDAADAEQVRPLLPGTAGVAVLVTSRSDLRGLTASHAAHPVPLDVLRPGEAGDLLAGILGERRVAAEPAAAARLAELCARLPLALRIAAANLAARPGRSLEAYADELAGDGRLAKLSIAGDREAAVRTAFDHSYAALEPAAARLFGLLGLHPGPDFTAASAAALLGCPPAAAEEPLDRLATAGLVQHTGADRFQFHDLLRLYAAERAAADPGHEAAWRRLCDWYLTSTDAATAVDFSGLAQLPRPRQPSGRFRAGPQALTWLDAERANLVAVVNRAATAGPYAIAWQLADQLRMFFFYRRHQPEWQATVTAALRAAEEHGDVLARGAMYHGLGLLRQSTGDSGAALAALHRALDDYRATGHQRGEAAILSNLAVHAGQHGEMRRALHWQEQGMEVLRSLDMPVQLANSLNTLGLIHVYLGQLGSGLACTTESIKVCLHHRQPPRAISPLINRSLVHHHLGRYEEALADATEALRLCREHRERHNKADAYEAVARAHLGRRRPDLAGPHAERALRTAREGGDPTEEADALITLARLHRMRGDLTRAADHLTAALALTRRCAFRHQEAEAHAALALLRLDTGDAATATDHAELALATARELDLPLTAHHALTALAAIAHATHTPGKAALHTAEAHRIEERTGYHPPPNPSPGTGGSAVLVRGGVITRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAR9</accession>
    <name>A0A0F7NAR9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_18040</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
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            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CsoR family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017093.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
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    <dbReference type="STRING" id="444103.AA958_18040"/>
    <dbReference type="EnsemblBacteria" id="AKH83792">
        <property type="protein sequence ID" value="AKH83792"/>
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    </dbReference>
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    <dbReference type="PATRIC" id="fig|444103.5.peg.3794"/>
    <dbReference type="OrthoDB" id="1868412at2"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="F:DNA binding"/>
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    </dbReference>
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        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
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        <property type="project" value="UniProt"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Trns_repr_metal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0186">Copper</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH83792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="111" mass="11934" checksum="C4E12DD98D427246" modified="2015-07-22" version="1">MTDTTATTAAAGTAPGSGPHGYSKDKEAHLKRLRRIEGQVRGLQRMVEEDVYCIDILTQVSASTKALQSFALQLLEEHLRHCVADAAARGGDEIDAKVEEATAAIARMLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAZ2</accession>
    <name>A0A0F7NAZ2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">YCII domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_23430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the YciI family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_23430"/>
    <dbReference type="EnsemblBacteria" id="AKH84668">
        <property type="protein sequence ID" value="AKH84668"/>
        <property type="gene ID" value="AA958_23430"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_23430"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4939"/>
    <dbReference type="OrthoDB" id="1780176at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005545">
        <property type="entry name" value="YCII"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03795">
        <property type="entry name" value="YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YCII" evidence="2">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH84668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="91" mass="10620" checksum="EB30918387931F02" modified="2015-07-22" version="1">MSYYVLDYSYVDDYLARRDAYREAHLDLIRECHRRGDLFMAGAMTEAPPRGLLVWRTEGPGPAEEFVRRDPYVANGLVDKWSIRPWNVVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NB31</accession>
    <name>A0A0F7NB31_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alpha-L-arabinofuranosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_29675</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 51 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018938.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_29675"/>
    <dbReference type="EnsemblBacteria" id="AKH85710">
        <property type="protein sequence ID" value="AKH85710"/>
        <property type="gene ID" value="AA958_29675"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_29675"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6265"/>
    <dbReference type="OrthoDB" id="620389at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046373">
        <property type="term" value="P:L-arabinose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010720">
        <property type="entry name" value="Alpha-L-AF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06964">
        <property type="entry name" value="Alpha-L-AF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00813">
        <property type="entry name" value="Alpha-L-AF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-L-AF_C" evidence="4">
        <location>
            <begin position="292"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="455"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH85710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="503" mass="54793" checksum="01F22C49AAB5E59A" modified="2015-07-22" version="1">MSATARFTLDPAFTVGEAGPRLFGSFVEHLGRCVYTGIYEPGHPAADPAGLRTDVLDLVRELGVTAVRYPGGNFVSGYKWEDGVGPRQDRPRRLDPAWQTTESNHFGLGEYADFLRKTGCEPVLALNLGTRGVAEAVELQEYANHPQGTALADLRIAHGSKEPYGIRLWCLGNEMDGPWQTGHKTAAEYGRLAAETARAMRQIDPGLELVACGSSNQAMPTFAEWERTVLTECYDLVDYISLHAYYEEVDGDRGSFLASAVDMESFIDNVVATCDHVGARLKSEKRINLSFDEWNVWYQSRFHAEFDRNPPGWAEVPRLLEDSYSVTDAVVVGSLLIALLRHADRVKLACLAQLVNVIAPIMTEPGGTAWRQTTFHPFAQAARHGRGTVLEVRADSPTYDTARYGRVPLLHATAVRDEASGAVTVFAVNRAQQAVLPVEIAVHGTGVTGIAGHSVLSDTDPEARNTAADPDRVTPHGAEGTALSGGVLRAVLEPMSWNVIRLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NB56</accession>
    <name>A0A0F7NB56_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_18875</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017214.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH83917">
        <property type="protein sequence ID" value="AKH83917"/>
        <property type="gene ID" value="AA958_18875"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_18875"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3962"/>
    <dbReference type="OrthoDB" id="911732at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005523">
        <property type="entry name" value="DUF317"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03771">
        <property type="entry name" value="SPDY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SPDY" evidence="2">
        <location>
            <begin position="63"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="SPDY" evidence="2">
        <location>
            <begin position="147"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH83917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="273" mass="29971" checksum="9476B350C89794E6" modified="2015-07-22" version="1">MKRKNGPGQGTTPGWGAGEQAEQHYLVQPRALAGGGDIRHVSHALYACGWQDKSKAGGPLALESPDRTVRIVYNPHVLPGGWAIHADANGRDDAWWAHLGRQTPVEIVAGLTDALTRPRDAHAPDVWAPLEQQGWNARPEGRHYSATSPDNTAWMQYHHKSDGEAMWWTGAKDAQGNGWSAQFSISTPMHLVQAFTTELASPEPVMRPRGRVPFSAQIRTWSVSVLPSQLRAWQQTRITAARAAAWAPSSAQRVRPRTTPARPYAPAGARTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBE8</accession>
    <name>A0A0F7NBE8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_30500</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019058.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_30500"/>
    <dbReference type="EnsemblBacteria" id="AKH85830">
        <property type="protein sequence ID" value="AKH85830"/>
        <property type="gene ID" value="AA958_30500"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_30500"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6445"/>
    <dbReference type="OrthoDB" id="1456605at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="PD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519464" evidence="2">
        <location>
            <begin position="36"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="domain" description="Amidohydro-rel" evidence="3">
        <location>
            <begin position="911"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="566"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH85830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="1054" mass="111317" checksum="2AB39CAFB5AFA928" modified="2015-07-22" version="1">MDAELFDLSRRRFLQATAAATAATAGAVLDTPAAAAPRAAAGTLSFTAATNGSATLAPAGDRLVAEVQNVLWSIPRKGGKATALTTAGLEPNRPQFAPDGSRLVVCAYRGGGFHLWTLRPDGSGLTQLTDGPHDDRAPAWSPDGGRLAFCSERGGDPVAGSPYRIWILTVATGELTQVTGLPDQQGPHQGGAWEDFDPAWSPDGARVFFVRAAVGDGGTLAARTVASVAADGTGEVRTEHTESTGAQVMTPAVGPGGRLAYLRTTAAPSASCTLVVDGAPVDLGDADVSPVPPRWISGDALLLTAGGQFRIVNPAAPAGPETIPFAAALPVDRPRYRTKAYDFADGGVRRVRAVHLPALSPDGRRLAFCALGALWTADVTCGGRPRKVLQAEKTRYVLAPAWTPDGRGLVYADDRDGLFAVRRRDLDSGEETVLAEGGRVFPALSPDGTRLACIDMTGNLVVTDLASGTEKVLAAPLGAGGLPGRPSWSPDGRSLALCDRNRLNQRFREGYNLIRLVDAATGAARLHPVSPHTSISDRYDSGPVWSPDGRWLAVVAESALWLLPVRPDGTPDGDPRQLTDEAADHPSFSGDGRQVAYLSAGRVRIADVASGSARTVRIPLDYRRPVAPDTVVHAGRLWDGTSDAVRDDADLVIRRGRVTAVEPHRAGRPAERRVDASARTVIPGLWDAHIHPWQSTYGGRQTALQLAYGITTAVSLGGFAYEQARIREAADAGELAGPRLLATGELLDGARVAYSMGRAHGTRAGLRRSLARAEGLDWDFVKTYVRAPGWVMAEAAAFAHERLGVRSGSHLCSPGIQLGQDLTTHLQATQRLEFGHATTASGRAYADLVDIYAATGDFHLIATPFTALPLLGADPALAEDPRVTVLMPPWDTAAVTQRAGQPPSEAELRTLATETDVYRRILAADGTVALGTDQPLVPVGLHLHLALRALHRAGLSAAGALRTATVLPARAFGAAKDLGTLEPGKYADVTVIDGDPFTDFATLVRTESVLRGGRQFAQEDLVRSFEPRATPRAGVDWLDVGRLMRRDGCCDTDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NC57</accession>
    <name>A0A0F7NC57_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH luxR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_25525</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018270.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_25525"/>
    <dbReference type="EnsemblBacteria" id="AKH85019">
        <property type="protein sequence ID" value="AKH85019"/>
        <property type="gene ID" value="AA958_25525"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_25525"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5380"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="943"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH85019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="1013" mass="108924" checksum="66087DF481A36509" modified="2015-07-22" version="1">MAAPPAPVAGAEAHDILGGVRAVRLSPVLAGRTEELETLDAALARASAGEPQAFVVAGEAGVGKTRLVEEFLTAARAAGAVTAAGGCVELGADGLPFAPFTTALRALQRELGDEAIAAAVGGREEELSRLLPDSSYAPPAGAPPHERDGRTRLFELTAQSLERLAADRTVVLALEDLHWSDRSTRELLSFLFRTMQATRLLVLATYRSDDIHRRHPLRPFLAELDRLRSVRRIELARLSRDEVAAQLTGIHGTVPAPTHADDIFRRSEGNPFFVEELSANPDCSLSESLRDLLLVRVERLTEPAQRVVRVAAEAGSHAEHALLAAVSGEGEDALLESLREAVAHNVLVPDEDGESYRFRHALLREAVRDDLLPGERSRLNRRYAEVLQADPTLVRAEQRLTRIARHWHHGRDSTRALPAVLAAAVEARCRHAFAEQYELLKRAMELWDDVPREIRARLRPADRIEDFETGAADTPLTELDLLAETVVAARLADERERALALTRRALEAIDEDAEPLRAAWFWVQRHWLVEDLARGDGRAELDHALLLVRDLPPSRVPALVLTAAASWEMLHRPGRPEGLAAAELAVRTAAAAGEENLELNAQVTLGIHLEDSGREEVGVGILREARDRARRSGDYTAAARAELNLAAALENLGRSREAAEVAADAARAAASRGRRDKVAFSLGNQVDSLVAMGRWDEAERVADRAERDAVVALTYGNLVQARARLALFRGDVARAEALLATARDRLGPQQTQPQMAIPLSTLTASVAAARGDLTGAREEAARTVDAGLAPGVHRYAWLLLEVAAEAEGDGRRVPAFARGTAAALARIRTAAAGLSCSAPVWAAHALLLRAQLARAAGDPDPAPWAAAAAAFEPLDRPYELARVRHRWAEALLATGDREGAAPLLADAHAAAGALGAVPLRTAVTALASRARVSLGGPDPAPADPVRALGLTSREQEVLRLVTAGRSNRQIAEELFISPKTASVHVSNLMAKLGVSARGEAAATAHRLRLFEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCG0</accession>
    <name>A0A0F7NCG0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">4-hydroxybenzoate 3-monooxygenase</fullName>
            <ecNumber evidence="2">1.14.13.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_32565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.14.13.2" evidence="2"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019397.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_32565"/>
    <dbReference type="EnsemblBacteria" id="AKH86170">
        <property type="protein sequence ID" value="AKH86170"/>
        <property type="gene ID" value="AA958_32565"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_32565"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6874"/>
    <dbReference type="OrthoDB" id="1770293at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018659">
        <property type="term" value="F:4-hydroxybenzoate 3-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="5"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="408" mass="45132" checksum="4CECB8B39C4EF765" modified="2015-07-22" version="1">MKQLRTQVAIVGAGPAGLLLSHLLHRQGVESVVLERRTREYVERRVRAGLLEHTTVELLRQCGLADRLDREGMRHGGFELRVAGHRNRLDIAALTGHSTYVYGQQELVKDMIRAREEADGQLRFSVADVALDLAEDEGPSTVRCSMDGRPTEITCDFVAGCDGFHGISRQCLPPALLTAHERRYPSAWLGILAATPPTSGELVYAVHERGFALASMRTPEISRLYLQVGPGESLSDWPDERIWKELHARLAVDGETSLTEGRVLERSLVALRSYVAEPMQHGPLFLAGDAAHIVPPTAAKGLNLAVEDVHVLNEAFRSWYATGDRAALDGYSATRLPAVWEAEEFSDWMADLLHRPPDDDPYAARLQQARLDAVVNSHTVARQLAERYVGLSRQTSGREGGAWSWNQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7ND07</accession>
    <name>A0A0F7ND07_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">AA958_32160</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CNQ-509</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10">Binds 1 zinc ion per subunit.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019334.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_32160"/>
    <dbReference type="EnsemblBacteria" id="AKH86106">
        <property type="protein sequence ID" value="AKH86106"/>
        <property type="gene ID" value="AA958_32160"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_32160"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6791"/>
    <dbReference type="OrthoDB" id="717704at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032837">
        <property type="entry name" value="G1PDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016205">
        <property type="entry name" value="Glycerol_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43616">
        <property type="entry name" value="PTHR43616"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13685">
        <property type="entry name" value="Fe-ADH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000112">
        <property type="entry name" value="Glycerol_dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 12" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="97"/>
            <end position="101"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 11">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10 11">
        <location>
            <position position="249"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10 11">
        <location>
            <position position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000112-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000112-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000112-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AKH86106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="354" mass="37169" checksum="C6F4C97E3CA4D269" modified="2015-07-22" version="1">MPVLTRLIPSPLTVDIRAGALDDLADLLSDQRVAPSGRLAFAISPRSGQALRDRFAPALPGADWFADADGTIDGAVRLADSIKRTGRYDAVVGLGGGKVIDSAKYAAARVGLPMVAVATNLANDGLCSPVSTLDNDAGRGSYGVPNPIAIVIDLDVIREAPARFVRAGIGDVTCKLSAVADWELSHRETGEPIDGLAAAMARSAGDSVLRHPGGIGDDDFLVILAEALVLCGIAMSVAGDSRPASGACHEISHAFDLLYPKRCALHGEQCGIGGTFATFLRGDRETALLMAQVLRRHGLPVLADDIGFADDEFVKAIEFAPQTRPGRYTILEHLDLSTDEIRDAYADYAKAIGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7ND08</accession>
    <name>A0A0F7ND08_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Coproporphyrin III ferrochelatase</fullName>
            <ecNumber evidence="7">4.99.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">cpfC</name>
        <name evidence="9" type="ORF">AA958_26925</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in coproporphyrin-dependent heme b biosynthesis. Catalyzes the insertion of ferrous iron into coproporphyrin III to form Fe-coproporphyrin III.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Fe-coproporphyrin III + 2 H(+) = coproporphyrin III + Fe(2+)</text>
            <dbReference type="Rhea" id="RHEA:49572"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:68438"/>
            <dbReference type="ChEBI" id="CHEBI:131725"/>
            <dbReference type="EC" id="4.99.1.9"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="6">
            <dbReference type="Rhea" id="RHEA:49574"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Porphyrin-containing compound metabolism; protoheme biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the ferrochelatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.99.1.9" evidence="7"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018505.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_26925"/>
    <dbReference type="EnsemblBacteria" id="AKH85268">
        <property type="protein sequence ID" value="AKH85268"/>
        <property type="gene ID" value="AA958_26925"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_26925"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5663"/>
    <dbReference type="OrthoDB" id="780534at2"/>
    <dbReference type="UniPathway" id="UPA00252"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004325">
        <property type="term" value="F:ferrochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006783">
        <property type="term" value="P:heme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00419">
        <property type="entry name" value="Ferrochelatase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03411">
        <property type="entry name" value="Ferrochelatase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00323">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001015">
        <property type="entry name" value="Ferrochelatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033644">
        <property type="entry name" value="Ferrochelatase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033659">
        <property type="entry name" value="Ferrochelatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11108">
        <property type="entry name" value="PTHR11108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00762">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="2 7" id="KW-0408">Iron</keyword>
    <keyword evidence="4 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>Fe-coproporphyrin III</name>
            <dbReference type="ChEBI" id="CHEBI:68438"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>Fe-coproporphyrin III</name>
            <dbReference type="ChEBI" id="CHEBI:68438"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH85268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="371" mass="39941" checksum="90698BBAB6181162" modified="2015-07-22" version="1">MPDVPSPQPYDALLLLSFGGPEGPDDVVPFLANVTRGRGIPRERLEEVGKHYYLFDGVSPINAQNRTLLAALRKDFAEAGLDLPVYWGNRNWAPYLTDTLREMTEAGHRRVLALVTSAYASYSGCRQYRENLAESLAELTAEGLEPPRVDKLRHYFNAPGFVRDMVAGVQDALARLPEDVRDGAHLAFTTHSIPTAAADTSGPPADHGDGGAYVAQHMDAAKLVADTVAVLTGVQRPWRLVYQSRSGAPHIPWLEPDVCDHLEELHAAGAPAVVMVPIGFVSDHMEVMYDLDTEAAAKAAELGLPAVRSATVGARPAFVETLRKLVLERAAAERGEPVERPALGRLGPSHDVCPAGCCPARDPRPATAGAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7ND13</accession>
    <name>A0A0F7ND13_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_26950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018509.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_26950"/>
    <dbReference type="EnsemblBacteria" id="AKH85273">
        <property type="protein sequence ID" value="AKH85273"/>
        <property type="gene ID" value="AA958_26950"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_26950"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5671"/>
    <dbReference type="OrthoDB" id="1550026at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="262" mass="27076" checksum="02DC545092EECC77" modified="2015-07-22" version="1">MAPTAGSGPAGPKTGILQRTRPDRRVRAALERVADAIVQTAPRVPVRDLATLRRQFPGLGPEEIADRLVAGAVKGSATVGAGIGAAAMMPAPPAMPAELAAEIVAVASIELKLIAELHEVYGVRAAGPARQRAMAYLGAWTDERGIDAAVLKGGISFDAVLGGPMRRRLRQQVLRRTVRNLPTLAPFLMGAAAGALMNRRDTGKLAERVRDDLRARQVPWDALTPAGGELAAPGNPGGRSGAGSTGTGLPKGDPRALPPGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7ND20</accession>
    <name>A0A0F7ND20_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dihydropteroate synthase</fullName>
            <shortName evidence="1">DHPS</shortName>
            <ecNumber evidence="1">2.5.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Dihydropteroate pyrophosphorylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_23260</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DHPS family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.15" evidence="1"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017893.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_23260"/>
    <dbReference type="EnsemblBacteria" id="AKH84637">
        <property type="protein sequence ID" value="AKH84637"/>
        <property type="gene ID" value="AA958_23260"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_23260"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4903"/>
    <dbReference type="OrthoDB" id="1275854at2"/>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00156"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004156">
        <property type="term" value="F:dihydropteroate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045031">
        <property type="entry name" value="DHP_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006390">
        <property type="entry name" value="DHP_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000489">
        <property type="entry name" value="Pterin-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20941">
        <property type="entry name" value="PTHR20941"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00809">
        <property type="entry name" value="Pterin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="SSF51717"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01496">
        <property type="entry name" value="DHPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00792">
        <property type="entry name" value="DHPS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00793">
        <property type="entry name" value="DHPS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50972">
        <property type="entry name" value="PTERIN_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pterin-binding" evidence="2">
        <location>
            <begin position="14"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU361205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH84637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="286" mass="30511" checksum="CB2F2EF3BAF69BA2" modified="2015-07-22" version="1">MLRLGSRTFAAHEPVIMAIVNRTPDSFYDQGATFRDEPALARVEQAVAEGAAIIDVGGVKAGPGEEVSAAEEVRRTAGFIAEVRRRHPSVVISVDTWRHEVAEAACAAGADLLNDAWGGVDPLVAEVAARHGAGLVCTHAGGVQPRTRPHRVAYDDVMADILRVTLGLAERAVELGVRRDGILIDPGHDFGKNTRHSLEATRRLGEMTAAGWPVLVSLSNKDFVGETLAKPVKERLIGTLATTAVSAWLGAQVYRVHEVAETRQVLDMVAAIAGHRPPAVARRGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7ND38</accession>
    <name>A0A0F7ND38_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Immediate-early protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_33760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019597.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_33760"/>
    <dbReference type="EnsemblBacteria" id="AKH86375">
        <property type="protein sequence ID" value="AKH86375"/>
        <property type="gene ID" value="AA958_33760"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_33760"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.7129"/>
    <dbReference type="OrthoDB" id="1719670at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH86375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="152" mass="16535" checksum="13B7B72E817DBDC1" modified="2015-07-22" version="1">MALFEVERTVRAPAVAVWERLTDWPAHGGRVPLTRITGVSVPAEGAGARFTARTGVGRVGFDDPMEVVEWSPPEAGRAVGRYRLVKRGQVVLGWAEIEVYGPEAGDGTAGPVRVVWREELGVRGVPRALDPLVAWTARRVFCRVLDGLLRAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7ND84</accession>
    <name>A0A0F7ND84_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_23695</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017967.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_23695"/>
    <dbReference type="EnsemblBacteria" id="AKH84712">
        <property type="protein sequence ID" value="AKH84712"/>
        <property type="gene ID" value="AA958_23695"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_23695"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4994"/>
    <dbReference type="OrthoDB" id="1821409at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH84712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="250" mass="25763" checksum="C79931A6809F332C" modified="2015-07-22" version="1">MGALTGKTALVTGASRGIGRAIAERLGRDGARVAVHYGSNEAAAKETVAAIEAAGGEAFAIRAELGVPGDAAALWAEFDRHADGLDILVNNAGVALQALIEDTDEAEFDRLFAVNTKAPFFVTKLGLSRLRDGGRIVNVSTVATHAALMPTLLAYTMTKSAVDAFTKFLSKSVGERGITVNAVAPGALDTDMNAAWLRDNDDAKAGMAAMSPLGRIPDVSEVADTVAYLVSGDAKVLTGTYVDVSGGVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDK8</accession>
    <name>A0A0F7NDK8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sulfate ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_28110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018692.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_28110"/>
    <dbReference type="EnsemblBacteria" id="AKH85458">
        <property type="protein sequence ID" value="AKH85458"/>
        <property type="gene ID" value="AA958_28110"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_28110"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5924"/>
    <dbReference type="OrthoDB" id="785019at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042626">
        <property type="term" value="F:ATPase-coupled transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13553">
        <property type="entry name" value="PBP2_NrtA_CpmA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010067">
        <property type="entry name" value="ABC_SsuA_sub-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044527">
        <property type="entry name" value="NrtA/CpmA_ABC-bd_dom"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01728">
        <property type="entry name" value="SsuA_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519393" evidence="1">
        <location>
            <begin position="30"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="372" mass="38992" checksum="BDA2A33319C8EED7" modified="2015-07-22" version="1">MSAPRRRRAAIRLLAGTAALPLLALTACGYGSDNDGKGDDAAPAAQGEKIGGLDEINIGFFGNVTHATPLVGLGDDGLITEELGGTAVKRQIFNAGPSAIEALNAGSVDMTWIGPSPAINGYTQADGRNLRIVAGATSGGASLVVNPDKIKTLDDLEGKRIATPQIGNTQDVALLNYLAGEGLEVEPESGKGDVLVIRQDNKEIPTTFQQGGLDGAWVPEPTASNLVAKGGEVLLNEKELWDDGTFVTTHLIVSQTFLKDHPDVVEAVVRGSVKTNAWIKENPDEAKTLVNEGIEEYSGKPLPDDVLDRAFGDIEVTDDPLASTLGDQADHSVRSGLLDEARTDGIYDLSILNKVLKSEGRPAVDDAGLGVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NEC2</accession>
    <name>A0A0F7NEC2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Hydroxyneurosporene methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_30405</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_30405"/>
    <dbReference type="EnsemblBacteria" id="AKH85814">
        <property type="protein sequence ID" value="AKH85814"/>
        <property type="gene ID" value="AA958_30405"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_30405"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6424"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031725">
        <property type="entry name" value="ASMT_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="O_MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16864">
        <property type="entry name" value="Dimerisation2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005739">
        <property type="entry name" value="O-mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Dimerisation2" evidence="5">
        <location>
            <begin position="8"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransf_2" evidence="4">
        <location>
            <begin position="108"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2 3">
        <location>
            <position position="244"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR005739-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH85814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="335" mass="36282" checksum="1D4ABDB32211E909" modified="2015-07-22" version="1">MAPPPFALLELAQGAMVSQAIYAAAELRVAEALTDGPLPVARLAEKTETDPESLRRLLRLLATYGIFTERKDGRFALTPMARALLPDAPMSMNGIALLMGHPTHWEDWAHFAEAVRTGEPSLPKLRGMGAFEYLEENPEYGGVFIRGMGSMSATETEPLLAAYDFSRFRTVVDFCGGRGDFLAGVLRKSPKARGVLSDPRVGENGAAAFLEKEGVADRCTIADGGLFDPVPEGGDAYVLKHIVHDWPEPQAVEILTNVRKAMNPGGRVLIMEMVLPDKRNAPHAGKLVDLWLMLLVGGRERTGALYGELLAQAGLKVERVVRTPAAISVVEASRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NEG2</accession>
    <name>A0A0F7NEG2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_17065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86835">
        <property type="protein sequence ID" value="AKH86835"/>
        <property type="gene ID" value="AA958_17065"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_17065"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3588"/>
    <dbReference type="OrthoDB" id="2004472at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="183" mass="19130" checksum="4E254CDB26300D54" modified="2015-07-22" version="1">MLLAGCGEESGSATGTGTPSSGGSPSTAEEYAEATRKEHDRAWPGIARKCRDVRPEPTAGAEGEEGVPENPKYGENNAYKQTTDVTPDELCRGEAHAARIAAALEDAAPADLRDEERTRRLFEDLGYGPDTVSARQNDAALVWWDVMVAGAGPCISGNTDPAAGIDVHGVYMEGGCTEPVGGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NEG6</accession>
    <name>A0A0F7NEG6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_30065</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018991.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH85763">
        <property type="protein sequence ID" value="AKH85763"/>
        <property type="gene ID" value="AA958_30065"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_30065"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6348"/>
    <dbReference type="OrthoDB" id="2002313at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH85763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="185" mass="20850" checksum="36165E4F97CB7FC7" modified="2015-07-22" version="1">MRIVQQRYPRDRVADWWRQWKHPREFRVAPERLDAGQREQVASHLTSLDAALADLAAARTAAREAAAAPSPAAEFDTGRLAEAATGVWKAQRKLDQQDGAPQKTSRQISKSVRTAREALQEGIELKIKDHDGEDYDPGLPLKVLSFEDDPSLTREVVLETFKPTIHFRGDRIQMGEVVVGRPPRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NER1</accession>
    <name>A0A0F7NER1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_26620</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RelA/SpoT family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018449.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_26620"/>
    <dbReference type="EnsemblBacteria" id="AKH85212">
        <property type="protein sequence ID" value="AKH85212"/>
        <property type="gene ID" value="AA958_26620"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_26620"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5601"/>
    <dbReference type="OrthoDB" id="204079at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015969">
        <property type="term" value="P:guanosine tetraphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05399">
        <property type="entry name" value="NT_Rel-Spo_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007685">
        <property type="entry name" value="RelA_SpoT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13291">
        <property type="entry name" value="ACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04607">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00954">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="SSF81271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HD" evidence="4">
        <location>
            <begin position="88"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="3">
        <location>
            <begin position="660"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="731"/>
            <end position="750"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH85212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="750" mass="80003" checksum="E5F8CDAC3D138B0D" modified="2015-07-22" version="1">MSAEVRSPGNPAGGPRRRGMARLDLRRLGRVALLGGASSRDGLPHALEHVAKAHRGFYPDADIRTLRTAYLLAEDAHRGQMRKSGDPYITHPLAVTLILAELGAETTTLTASLLHDTVEDTEVTLDQVRSGFGEEVAYLVDGVTKLEKVDYGAAAEPETFRKMLVATGSDVRVMSIKLADRLHNMRTLGVMRREKQVRIARVTHDVLIPLAERLGVQAIKTELEDLAFAVLHPEDYARSRELLLANAGRPDPLEETAAEMREVLHAAGITAEVAIRPRHIVSVHRVLQKRGELRGTDFGRLLVLVPEAADCYAVLGELHTCFKPVPAEFKDFIAVPKFNLYQSLHTAVADQRGYVVETLVRSRQMHRVAEAGVVALTSPLARPAAGQVGDWLKRLLEWQRATPDPDAFWSALREDLAPDQEITVFCDPGGPLVLPAGASCVDAAYARHGETAHTLVGARVNGRLAGLGTRLRDGDALTLLLAPEASGPAPEWLDHAQTPAARIAITRWLGDHPAAQPADAAIPLPADYVPAAPAAPGSRAHDEAAAPVGVPAADAPADDVAADDVAADDVPAGDAPADGIPRAAEPAVAELPGATPRLARCCTPVPPDAVTGFVIRGGAVVAVHRAQCATVARMAAAGRRELRVHWRTGEGAPPADLRVTLKAEAFVRAHLLADLTEAIAAEGVAIVAADVEPPHEQRVRHTYTLQLPDPAGLPGLMRAMRKVPGVYDVSRAQHPAGADGQAPGLRARTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NF37</accession>
    <name>A0A0F7NF37_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_18860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86881">
        <property type="protein sequence ID" value="AKH86881"/>
        <property type="gene ID" value="AA958_18860"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_18860"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3959"/>
    <dbReference type="OrthoDB" id="1981280at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="189" mass="21113" checksum="AFA4EF461199FB4A" modified="2015-07-22" version="1">MSTDHRHRALLRRLDDYLRDSEKILAGWDIYSEEHTDLDGWPHDEHAYGIRAGQRDADAAAAFEALHTGARHLLATAEAQLARLPADTVQSRWRWQTDVLRSALDQLDELHDQWLGTRDGLPANASPGTAAFDDAQAEYHAEAWSHLDTWATHGYALREINTAARNARLRRSAPPTTAPAPGARNPART</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NF94</accession>
    <name>A0A0F7NF94_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_21595</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020298.1">
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86946">
        <property type="protein sequence ID" value="AKH86946"/>
        <property type="gene ID" value="AA958_21595"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_21595"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4547"/>
    <dbReference type="OrthoDB" id="1693713at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH86946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="119" mass="13648" checksum="34F5A9EBF76A2871" modified="2015-07-22" version="1">MEEGRIFREAWIAGVKKHFPGEPKPGYVTPWEETPDWEREAAAAVCRQVREFIEVSGGSTGRLSREQRGRFVAICWIAQIHHRIEDPKPGYVADWSELPGWQQETDADIFDAIEHASSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFD1</accession>
    <name>A0A0F7NFD1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_32585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86174">
        <property type="protein sequence ID" value="AKH86174"/>
        <property type="gene ID" value="AA958_32585"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_32585"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6880"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519488" evidence="1">
        <location>
            <begin position="25"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="64" mass="6923" checksum="80C2370C2437CB4B" modified="2015-07-22" version="1">MCFCLSQMTAQRSTVWACSTGASASETISPGRMKLSSVATPAAAWTARSFYSKDRTMRARAARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFD3</accession>
    <name>A0A0F7NFD3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Methionine ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_23155</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020346.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_23155"/>
    <dbReference type="EnsemblBacteria" id="AKH86981">
        <property type="protein sequence ID" value="AKH86981"/>
        <property type="gene ID" value="AA958_23155"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_23155"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4881"/>
    <dbReference type="OrthoDB" id="1101128at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="7"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH86981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="335" mass="36447" checksum="EB42B901C381C142" modified="2015-07-22" version="1">MTALLDVRDLHVEFRTREGVAKAVNGVSYSVAPGETLAVLGESGSGKSVTAQAVMGILDSPPGFVTGGQVLFQGEDLLKLGREARRKVRGERMAMIFQDALSSLNPVLTVGFQLGEMFRVHRGASRAEAKARSIELMERVRIPAARERVNDYPHQFSGGMRQRIMIAMALALGPELIIADEPTTALDVTVQAQVMDLLAELREETGMGLILITHDLGVVADVADKIAVMYAGRIMETAPVHDLYKAPAHPYTRGLLDSIPRLDQKGRELSAIRGTPPSLLAIPPGCPFHPRCPRAQDVCVTDRPPLYEVTDDAGHPLPGRGSACHFWKDQLHDRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFJ6</accession>
    <name>A0A0F7NFJ6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribosomal protein S12 methylthiotransferase RimO</fullName>
            <shortName evidence="7">S12 MTTase</shortName>
            <shortName evidence="7">S12 methylthiotransferase</shortName>
            <ecNumber evidence="7">2.8.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Ribosomal protein S12 (aspartate-C(3))-methylthiotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Ribosome maturation factor RimO</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rimO</name>
        <name evidence="12" type="ORF">AA958_26475</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[sulfur carrier]-SH + AH2 + L-aspartate(89)-[ribosomal protein uS12]-hydrogen + 2 S-adenosyl-L-methionine = 3-methylsulfanyl-L-aspartate(89)-[ribosomal protein uS12]-hydrogen + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:37087"/>
            <dbReference type="Rhea" id="RHEA-COMP:10460"/>
            <dbReference type="Rhea" id="RHEA-COMP:10461"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:29961"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="ChEBI" id="CHEBI:73599"/>
            <dbReference type="EC" id="2.8.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="7">Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the methylthiotransferase family. RimO subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.8.4.4" evidence="7"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_26475"/>
    <dbReference type="EnsemblBacteria" id="AKH87046">
        <property type="protein sequence ID" value="AKH87046"/>
        <property type="gene ID" value="AA958_26475"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_26475"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5572"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103039">
        <property type="term" value="F:protein methylthiotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018339">
        <property type="term" value="P:peptidyl-L-beta-methylthioaspartic acid biosynthetic process from peptidyl-aspartic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01865">
        <property type="entry name" value="MTTase_RimO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005839">
        <property type="entry name" value="Methylthiotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020612">
        <property type="entry name" value="Methylthiotransferase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013848">
        <property type="entry name" value="Methylthiotransferase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038135">
        <property type="entry name" value="Methylthiotransferase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005840">
        <property type="entry name" value="Ribosomal_S12_MeSTrfase_RimO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041582">
        <property type="entry name" value="RimO_TRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43837">
        <property type="entry name" value="PTHR43837"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18693">
        <property type="entry name" value="TRAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00919">
        <property type="entry name" value="UPF0004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01061">
        <property type="entry name" value="methylthiotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00089">
        <property type="entry name" value="TIGR00089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51449">
        <property type="entry name" value="MTTASE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01278">
        <property type="entry name" value="MTTASE_RADICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="6 7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="12" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 7 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MTTase N-terminal" evidence="10">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="11">
        <location>
            <begin position="177"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="TRAM" evidence="9">
        <location>
            <begin position="410"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="129"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="484"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AKH87046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="503" mass="52862" checksum="B9B883130E804603" modified="2015-07-22" version="1">MDSEELAGRLAADGWDLVTDAAAADVAVVNTCGFVEAAKKDSVDALLEANDLKDTGRTQAVVAVGCMAERYGKELADALPEADGVLGFDDYADISARLQTILSGGGHAAHTPRDRRKLLPISPAERQDAAARGAAALPGHGDPGAADPADAATAAPADLPAGVAPASGPRPPLRRRLGSGPVASVKLASGCDRRCTFCAIPSFRGSFVSRRPSDVLGETRWLAGQGVREIMLVSENNTSYGKDLGDVRLLETLLPELAAVDGIERIRVSYLQPAEMRPGLIDVLTSTEKVAPYFDLSFQHAAPEVLRAMRRFGDTERFLQLLAEIRSRAPEAGARSNFIVGFPGETERDVEELERFLTAARLDAVGIFGYSDEEGTEAATYGSKVAPEAVAERLAHMTRLAEELTAQRAEERVGETVRVLVDAVEEPGADPVADAGEVAGRAAHQAPETDGVTLLAGGTARQAAPGALVTAKVVASEGVDLVAEPIGEPDRRRPGEPAEEAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFV6</accession>
    <name>A0A0F7NFV6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nitrate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_29020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_027752283.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_29020"/>
    <dbReference type="EnsemblBacteria" id="AKH85617">
        <property type="protein sequence ID" value="AKH85617"/>
        <property type="gene ID" value="AA958_29020"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_29020"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6114"/>
    <dbReference type="OrthoDB" id="1975985at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051131">
        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020945">
        <property type="entry name" value="DMSO/NO3_reduct_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003765">
        <property type="entry name" value="NO3_reductase_chaperone_NarJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036411">
        <property type="entry name" value="TorD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43680">
        <property type="entry name" value="PTHR43680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02613">
        <property type="entry name" value="Nitrate_red_del"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89155">
        <property type="entry name" value="SSF89155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00684">
        <property type="entry name" value="narJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="193"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH85617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="221" mass="24599" checksum="0F27D9B6D8C4EA25" modified="2015-07-22" version="1">MRRKKQTAVQPHTEAWHPNAWQTHSLLLAYPGEQFPEHLTLARRVATTLPDQVAEPLLRFADHAEDTAATDLATDYVATFDHRKRCCPYLTYYAHGDTRKRGVALVRLKHTYATAGWRLNDDELPDHLAVVLEFASAEPAAGHRLLTEHRAGLELLRLALREDRSPWAHLLRSISATLPALAGDERAAVARLAAEGPPEEQVGLAPYTPESYVPARPGGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NG49</accession>
    <name>A0A0F7NG49_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Riboflavin biosynthesis protein RibBA</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="13">3,4-dihydroxy-2-butanone 4-phosphate synthase</fullName>
                <shortName evidence="13">DHBP synthase</shortName>
                <ecNumber evidence="13">4.1.99.12</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="13">GTP cyclohydrolase-2</fullName>
                <ecNumber evidence="13">3.5.4.25</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="13">GTP cyclohydrolase II</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="13" type="primary">ribBA</name>
        <name evidence="16" type="ORF">AA958_33355</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 13">Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.</text>
    </comment>
    <comment type="function">
        <text evidence="13">Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>D-ribulose 5-phosphate = (2S)-2-hydroxy-3-oxobutyl phosphate + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18457"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
            <dbReference type="EC" id="4.1.99.12"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>GTP + 4 H2O = 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + formate + 3 H(+) + 2 phosphate</text>
            <dbReference type="Rhea" id="RHEA:23704"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58614"/>
            <dbReference type="EC" id="3.5.4.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="13">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="13">Binds 2 divalent metal cations per subunit. Magnesium or manganese.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="13">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 13">Cofactor biosynthesis; riboflavin biosynthesis; 2-hydroxy-3-oxobutyl phosphate from D-ribulose 5-phosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 13">Cofactor biosynthesis; riboflavin biosynthesis; 5-amino-6-(D-ribitylamino)uracil from GTP: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">In the C-terminal section; belongs to the GTP cyclohydrolase II family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 13">In the N-terminal section; belongs to the DHBP synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.12" evidence="13"/>
    <dbReference type="EC" id="3.5.4.25" evidence="13"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019528.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_33355"/>
    <dbReference type="EnsemblBacteria" id="AKH86303">
        <property type="protein sequence ID" value="AKH86303"/>
        <property type="gene ID" value="AA958_33355"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_33355"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.7044"/>
    <dbReference type="OrthoDB" id="900513at2"/>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00399"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008686">
        <property type="term" value="F:3,4-dihydroxy-2-butanone-4-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003935">
        <property type="term" value="F:GTP cyclohydrolase II activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00641">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00179">
        <property type="entry name" value="RibA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00180">
        <property type="entry name" value="RibB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01283">
        <property type="entry name" value="RibBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000422">
        <property type="entry name" value="DHBP_synthase_RibB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032677">
        <property type="entry name" value="GTP_cyclohydro_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000926">
        <property type="entry name" value="RibA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036144">
        <property type="entry name" value="RibA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016299">
        <property type="entry name" value="Riboflavin_synth_RibBA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00926">
        <property type="entry name" value="DHBP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00925">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142695">
        <property type="entry name" value="SSF142695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="SSF55821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00505">
        <property type="entry name" value="ribA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00506">
        <property type="entry name" value="ribB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 13 16" id="KW-0456">Lyase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13" id="KW-0464">Manganese</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="8 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0686">Riboflavin biosynthesis</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="GTP_cyclohydro2" evidence="15">
        <location>
            <begin position="253"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="DHBP synthase" evidence="13">
        <location>
            <begin position="1"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="D-ribulose 5-phosphate binding" evidence="13">
        <location>
            <begin position="42"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="D-ribulose 5-phosphate binding" evidence="13">
        <location>
            <begin position="157"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="GTP cyclohydrolase II" evidence="13">
        <location>
            <begin position="219"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="219"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for GTP cyclohydrolase activity" evidence="13">
        <location>
            <position position="379"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; for GTP cyclohydrolase activity" evidence="13">
        <location>
            <position position="381"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="43"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="301"/>
            <end position="305"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="345"/>
            <end position="347"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="367"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="402"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="407"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="site" description="Essential for DHBP synthase activity" evidence="13">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <feature type="site" description="Essential for DHBP synthase activity" evidence="13">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AKH86303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="461" mass="49181" checksum="EA4BA7ED40249C90" modified="2015-07-22" version="1">MTALTTWPPAGEAEDLRLDPVERAIEEIAAGRPVVVVDDEDRENEGDLVVAAELITPATVAFMMRECSGMICMPMTGAELDRLGIPQMVRRNTESLRTAFTVTVDASAAHGVTTGISASDRAATIRLLADPAAVAADFVRPGHIFPLRAREGGVLVRDGHTEAGVDLARLAGLRPAAAIVEIAGEDGEMLRLPQLVPFARRHGFAIISIADLIEYRRTTERAPADPEPPAAPAAAGRAAVPTDAPADAPAVRREAETRLPTAYGDFTAYGYRSAADGVEHIALVMGDVGGVDDLGQGVLVRLHSECLTGDVFGSQRCDCGPQLHASLRRVAAEGRGVVIYLRGHEGRGIGLLSKLRAYELQERGRDTLDANLELGLPADARDYAAGARMLADLGVTSVRLMTNNPEKVDALLRHGLAVTGREPTPVEAGEHNLRYLRTKRDRMGHHLPWLDGAPVAVCSNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NGP5</accession>
    <name>A0A0F7NGP5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_08230</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_08230"/>
    <dbReference type="EnsemblBacteria" id="AKH86609">
        <property type="protein sequence ID" value="AKH86609"/>
        <property type="gene ID" value="AA958_08230"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_08230"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1736"/>
    <dbReference type="OrthoDB" id="551294at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="1"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="267"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="31"/>
            <end position="38"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH86609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="517" mass="56865" checksum="F54972D00C068FA9" modified="2015-07-22" version="1">MRAITKTFPGVTALADVSLTVAPGEIHAVCGENGAGKSTLMKVLSGVHPHGSYEGEIFFEGAPCAFKDIAASEERGIVIIHQELALVPYLSIAENIFLGNEQAKRGVISWNETLRAAAALLKRVGLGAEKPQTRIADIGVGKQQLVEIAKALSKKVKLLILDEPTAALNDEDSRKLLDLIREFRDQGIACILISHKLNEIRQVADRVTILRDGRTIETLAVRDAESGGEGPALSEDRIIRAMVGRDLDHRFPERSHYRGDDEGTVALAVEGWTVRHPIDHERKVVDDVSIEVRRGEIVGIAGLMGAGRTELAMSVFGRSYGRYESGTVRVDGREVDTRTVPDAVRHGIAYVTEDRKTYGLNLIDNVMRNITLSALPKLVRRGAVDEHEERRVAEGYRTSMNIKTPTVFEPVNRLSGGNQQKVVLSRWIHADPEVLLLDEPTRGIDVGAKYEIYTVIDRLAARGKAVVFISSELPELLGMCDRIYTMAAGRVTGEVPRSQATQEVLMRHMTTHVRDEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NGQ6</accession>
    <name>A0A0F7NGQ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Haloacid dehalogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_08625</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_08625"/>
    <dbReference type="EnsemblBacteria" id="AKH86619">
        <property type="protein sequence ID" value="AKH86619"/>
        <property type="gene ID" value="AA958_08625"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_08625"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1819"/>
    <dbReference type="OrthoDB" id="1167152at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH86619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="208" mass="22401" checksum="E1D24029A4F4448E" modified="2015-07-22" version="1">MIFDCDGVLVDGERICVKVDAVVMADLGCAFTEAEMAELFVGSSVEVYTAVVEERLGRRLEKGWHRQYDHLYRAALEEQLTAVDGIPEVLDGLTTGFCVASNGDHAAIRRSLTTTGLLRHFENRIFSAADVPRGKPAPDLFRHAARAMGVPPDRCAVVEDSAYGVRAARAAGMRAFGYCGGLTPAARLAGPGTVVFDEMRDLPALLAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NGW9</accession>
    <name>A0A0F7NGW9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_31410</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019205.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_31410"/>
    <dbReference type="EnsemblBacteria" id="AKH85977">
        <property type="protein sequence ID" value="AKH85977"/>
        <property type="gene ID" value="AA958_31410"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_31410"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6637"/>
    <dbReference type="OrthoDB" id="1619224at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="39"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="308"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="101"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH85977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="338" mass="36920" checksum="D1AE14424F86CFDA" modified="2015-07-22" version="1">MTTIDSRPAANSADPRPPAGGRPRARRPMTASRRENRAGLAFVSPTFLVVLVVVIVPILWTVLLAFQDAKLVDIQGMGLFGNWSLENFSDVFASAGFWSSLGTTLVYTVGATAGSVLLGLVAALALRRPFRGRGLLRGSMLLPYVAPVVAVAFVWEVALSPQYGVVNEWGRDAFGWDDPIAFLSTRQYEVNLLGWHVDIPLALLTVIAFEIWRYFPFAFLFLLARLQAVPDTLEEAATVDGATVSQRFRHVLLPQLMPVIALLCVLRFIMTFNKFDDVYLLTGGGAGTDVAAVRVYDFLTSRFDVGAAAAQALVLAAVLTVLLGIYFTFFAKRVQEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NH03</accession>
    <name>A0A0F7NH03_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carbon monoxide dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_31615</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019240.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_31615"/>
    <dbReference type="EnsemblBacteria" id="AKH86012">
        <property type="protein sequence ID" value="AKH86012"/>
        <property type="gene ID" value="AA958_31615"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_31615"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6677"/>
    <dbReference type="OrthoDB" id="117507at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000674">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036856">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016208">
        <property type="entry name" value="Ald_Oxase/xanthine_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008274">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037165">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11908">
        <property type="entry name" value="PTHR11908"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01315">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02738">
        <property type="entry name" value="Ald_Xan_dh_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01008">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54665">
        <property type="entry name" value="SSF54665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56003">
        <property type="entry name" value="SSF56003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ald_Xan_dh_C" evidence="2">
        <location>
            <begin position="25"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH86012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="792" mass="84339" checksum="88E8E9E25883EDCE" modified="2015-07-22" version="1">MTTAEQAAPAIGRSHPRKEDARLVTGRTSWTDNITLPGMLHMTVLRSPMAHARIDRLDLTAVRERPGVVAAFSAADLDGELGSLPCAWPVTEDIVHPDHPPLAVGEVRHAGDPVAVVVARDRYTAADALEAVEVDYTPLPPVLDMEAALAGGAPLVHADKGTNRCFDWPLASGDYAAARARADVVVTRRYVQQRLIPNAMEPRAVVAAPAATGADEYTLYSATQIPHILRVMLAVVTGIPEQKIRVIAPDVGGGFGSKLQVYAEEALALVVAKRLGRPVKWTESRSEGYLATHHGRDQIQDVEVAATRDGRLLGMKVDLLADMGAYLMLVTPGIPILGAFMYPGIYKMDAYAFHCTGVFTTKTPTDAYRGAGRPEATYAVERVMDELAAELGLDPVELRRRNWIGHGEFPYTSVAGLTYDSGNYEAATDKALAHFGYAALRAEQRERHEHGDTVRLGIGVSTYTEMCGLAPSRVLRDLRYAAGGWEAASIRMLPTGKVEVITGTSPHGQGHATTWSQIAADVLGVPVEDVDVLHGDTRIAPQGMDTYGSRSLVVGGVAVHGAAVKVVGKARRVAAHLMEASEEDLEFTAGTFAVRGSPEATKTIQEVAFATFTGHDLPDGMEPTINAGHVVEPDNFSYPHGTHLCAVEVDTETGAVRIRSYVAVDDVGKVVNPLIVEGQVHGGLAQGIAQALYEEAVYDDDGNLVSGTLADYHVPAAPDLPDFVTDRTETPATSNPLGVKGVGEAGTIASTPAVVGAIVDALRPLGVTDVRMPCSPERVWRAIQDARKGGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NHF0</accession>
    <name>A0A0F7NHF0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_12830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020009.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_12830"/>
    <dbReference type="EnsemblBacteria" id="AKH86728">
        <property type="protein sequence ID" value="AKH86728"/>
        <property type="gene ID" value="AA958_12830"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_12830"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2698"/>
    <dbReference type="OrthoDB" id="1036370at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH86728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="66" mass="6966" checksum="8CDEF95B930A2A43" modified="2015-07-22" version="1">MLAELSRGTPGTVACRNLRMSPRTYSRRVAELLECLGAQSRFQGGAQAVRRGWLVGACLAGTAEGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NHN3</accession>
    <name>A0A0F7NHN3_9ACTN</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_21375</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020290.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86939">
        <property type="protein sequence ID" value="AKH86939"/>
        <property type="gene ID" value="AA958_21375"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_21375"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4500"/>
    <dbReference type="OrthoDB" id="2043895at2"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH86939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="88" mass="10237" checksum="2005B75A931B5956" modified="2015-07-22" version="1">MSVMQTVWHERRRRFAAADARRRRARGAREAFAGRVRGDLAAELPDEDLGEDLVESLDLYRMGSKPRCEEVEYLDLVQEAVERMAWGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NHP8</accession>
    <name>A0A0F7NHP8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_22035</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86959">
        <property type="protein sequence ID" value="AKH86959"/>
        <property type="gene ID" value="AA958_22035"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_22035"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4641"/>
    <dbReference type="OrthoDB" id="2056469at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH86959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="68" mass="7094" checksum="372D4F0E5AE71C65" modified="2015-07-22" version="1">MMIDETRGAPDTVVTVPINSPVQGAAVAVDCTALTARRIRAGTCLGTVEDATMTRVSAALRVVLDLHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NHR5</accession>
    <name>A0A0F7NHR5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_23490</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020355.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_23490"/>
    <dbReference type="EnsemblBacteria" id="AKH86989">
        <property type="protein sequence ID" value="AKH86989"/>
        <property type="gene ID" value="AA958_23490"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_23490"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4952"/>
    <dbReference type="OrthoDB" id="678616at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13970">
        <property type="entry name" value="ABC1_ADCK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034646">
        <property type="entry name" value="ADCK3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC1" evidence="2">
        <location>
            <begin position="93"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="442"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH86989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="466" mass="50842" checksum="5603FFA7D71E0D44" modified="2015-07-22" version="1">MSDLPRKAITRTARLASLPVGFAGRATWGLGKRLGGRPAELVARELQQRTAEQLFKTLGELKGGAMKFGQALSVFESALPEEIAGPYRAALTKLQEAAPPMPVRTVHGALAERLGPDWRDLFLEFEDTPAAAASIGQVHRAVWHDGREVAVKVQYPGAGKALLSDLAQLGRFARLLGPLVPGLDIKPLIQELRDRVSEELDYGLEARAQSAYAEEFADDPDVLVPDVVHQADQVLVTEWLDGVPVSELIANGSRAERDRVGQLLARFLFAGTARTGLLHADPHPGNFRLVKEGEPEEWRLGVMDFGTVDRLPGGLPEEIGIALGMTLEGEADEVYELLREQGFVKPDVALDPEAVIDYLLPIIEPAAVAEFAFSREWMRTQAARIADPRNPAHQLGRQLNLPPSYLLIHRVTLSTIGVLCQLGAQVRMREELTEWLPGFAEYAEGGRPEDDPHEGSATEDPATATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NI02</accession>
    <name>A0A0F7NI02_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_33775</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
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            <taxon>Streptomyces</taxon>
        </lineage>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019599.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_33775"/>
    <dbReference type="EnsemblBacteria" id="AKH86377">
        <property type="protein sequence ID" value="AKH86377"/>
        <property type="gene ID" value="AA958_33775"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_33775"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.7133"/>
    <dbReference type="OrthoDB" id="1001343at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="SSF48239"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH86377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="295" mass="30983" checksum="68A43C0B7B338ED7" modified="2015-07-22" version="1">MTADLSAASSFMAAHARLLDRRRFELLLGGTDPAAVLAAVDGYRNPDGGYGWGLEPDLRAPESQPGGALHAFEAFVDAAPATTPHAARLCDWLLSVTLPDGGLPFALPVADPTGCAPFWTRADPAVSALQSTAFAAGTALRLAAHDPAVAAHPWLERATRYCLDAIENIGDQPHAIELSFAIRFLDAAADTRPRATALLERLRALIPGDGVLPVAGGSEGEAIRPLDVAPEPGRPARTLYAPEAVDADLRRLAAGQQEDGGWLVDFGSFSPAAALEWRGYRTVGAVAVLKQNSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NI20</accession>
    <name>A0A0F7NI20_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH luxR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_19645</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_19645"/>
    <dbReference type="EnsemblBacteria" id="AKH86913">
        <property type="protein sequence ID" value="AKH86913"/>
        <property type="gene ID" value="AA958_19645"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_19645"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4139"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="272"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH86913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="335" mass="37679" checksum="D5B55C5504AB896F" modified="2015-07-22" version="1">MGVFGVSPAEEQLYRHFLRNPDSPSEGVHVKLGLDRRETEEAMDRLIRLRLLRPGDRPGWFVPVDPEQAVARLTEMRLREMYQEIQRLTQSRHVLTTLRAETAAPADGGGQAGAYGGEHGVEEIDDREALSNRMEELVFFAREEIASVEPGFHLMSEAVLKRRAVEWRALKRGVRRRLVLPADTLRHPRVAGHVRELLARGGEVRVVEEISDQLAVYDGRVALMPKDPKNLEEGALLVRGRGLVSTLSGLFEKVWEQAGDVSVELREPVEPEPELSEAELRVLRMMCEVGKDETGARDLGVSVRTYRRHIADVLRVLGASTRAQAALLARERGWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NI30</accession>
    <name>A0A0F7NI30_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thioredoxin reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_20220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_20220"/>
    <dbReference type="EnsemblBacteria" id="AKH86923">
        <property type="protein sequence ID" value="AKH86923"/>
        <property type="gene ID" value="AA958_20220"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_20220"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4258"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="1">
        <location>
            <begin position="10"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="332" mass="33805" checksum="63D8C435DD691477" modified="2015-07-22" version="1">MADEPAESYEAVVVGGGAAGLTGALMLARSRRSVAVIDAGAPRNAPADGVHGLLGREGMPPGELLARGRAEVRGYGGHVVPGEVTGVAREPADGARDGAAGEGEGGFVVTLAGGRTVRARRLLVTTGLVDELPAVPGVRERWGRDVLHCPYCHGWEVRDQAIGVLATGPMALHQALLFRQLSADVTYFAHTTEPPAGEDAEQLDALGVRVVTGEVAGLEIAADRLTGVRLADGTVVPRQALAVAPRMVARSGLLTALGLTPVAHPSGMGEHVPADATGRTDVPGVWVAGNVTDMTAQVHAASSAGAMAGAQINADLAAEDARRAVAARRVGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NJT0</accession>
    <name>A0A0F7NJT0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Rossmann fold nucleotide-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_26075</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020419.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_26075"/>
    <dbReference type="EnsemblBacteria" id="AKH87042">
        <property type="protein sequence ID" value="AKH87042"/>
        <property type="gene ID" value="AA958_26075"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_26075"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5490"/>
    <dbReference type="OrthoDB" id="902542at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031100">
        <property type="entry name" value="LOG_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03641">
        <property type="entry name" value="Lysine_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH87042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="367" mass="39295" checksum="6C6D8D780D20FB06" modified="2015-07-22" version="1">MPHSPFEIESLAEFDAAVASGSISGFRVQSVDLTDRTRLLLTADVHGAVFLGCPMAEEAAHRVQRDGALVFPVVPDLPFDPYRGALYTPDELFAGLARGYEQTPDARSYAWFQRTRAEHDIFAAVIRGMHDESMSNALDERLRACRPVVGVMGGHALERGGEDYAGAARLGRALVRAGFDVATGGGPGAMEAANLGAYAVEFDDAMLDEAVRMLGKAPSFTPSVAQWAEAAFAVRERWPGGGDSIGIPTWFYGHEPPNAFAGHIAKYFANALREDGLLARSTAGVVFLPGAAGTVQEIFDAATPNYYESRGEPRPMVLVGRDHWSARLPAWQLLSALADGRPMAPRIALVDGVEEAPEALLKLGAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NJX7</accession>
    <name>A0A0F7NJX7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Exodeoxyribonuclease III</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_28520</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA repair enzymes AP/ExoA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020482.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_28520"/>
    <dbReference type="EnsemblBacteria" id="AKH87087">
        <property type="protein sequence ID" value="AKH87087"/>
        <property type="gene ID" value="AA958_28520"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_28520"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6009"/>
    <dbReference type="OrthoDB" id="1893707at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008853">
        <property type="term" value="F:exodeoxyribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09086">
        <property type="entry name" value="ExoIII-like_AP-endo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004808">
        <property type="entry name" value="AP_endonuc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037493">
        <property type="entry name" value="ExoIII-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43250">
        <property type="entry name" value="PTHR43250"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00633">
        <property type="entry name" value="xth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51435">
        <property type="entry name" value="AP_NUCLEASE_F1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="3">
        <location>
            <begin position="4"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="241"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="241"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH87087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="263" mass="29229" checksum="814A16F7D92893B8" modified="2015-07-22" version="1">MRIATWNVNGINPRLPRILQWLEETAPDVVCFQELKCTEEAFPGAALAGLGYEAAIRADGRWNGVAVVSRVGLADVTVDLPDQPQYEGVTEPRALGATCGPARVWSLYVPNGRDVGHAHYAYKLRWLEALREMAAQEAAGERPYALLGDYNVAPKDEDVWDISLFGGHTHVSKAERTALDELQKFAGLGEVYPRALKYDIPFTFWDYRQLGFQKNKGMRIDHVYGNAAFTAAVTDAYVDREARRPGKDKNPSDHAPVVVDLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-10-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MYE8</accession>
    <name>A0A0F7MYE8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_02630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH81250">
        <property type="protein sequence ID" value="AKH81250"/>
        <property type="gene ID" value="AA958_02630"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_02630"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.562"/>
    <dbReference type="OrthoDB" id="2201740at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH81250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="127" mass="13930" checksum="BE83B729057CBC2B" modified="2015-07-22" version="1">MSVKQLRNLVTVYDWVGFNDSGPTTAVASTDYAVCTDSTGDIDWARQTLYGKQFVMRNPDGVSENDAYSSVQTFNGCDIRLSDWVNNNVDGGRSAWINSCSNLNGSGEGDCPTVNNWNNRASSWQLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MYR7</accession>
    <name>A0A0F7MYR7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Elongation factor G</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_03340</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_03340"/>
    <dbReference type="EnsemblBacteria" id="AKH81375">
        <property type="protein sequence ID" value="AKH81375"/>
        <property type="gene ID" value="AA958_03340"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_03340"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.710"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16262">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01434">
        <property type="entry name" value="EFG_mtEFG1_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03713">
        <property type="entry name" value="EFG_mtEFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009022">
        <property type="entry name" value="EFG_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035649">
        <property type="entry name" value="EFG_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="4">
        <location>
            <begin position="1"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH81375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="692" mass="74472" checksum="FC0BFF64A0C6B8CA" modified="2015-07-22" version="1">MEALAFTTKALTRAGRVEDGGCVSDYDEIEQRQQRSVQLSLVPVEWDGIKINLLDTPGYADFVGELRAGLRAADAALFVVSAADGVDGATRMLWDECAAVGMPRAIVVTHLDAARADFDQMTETCREAFGGDDPDAVLPLYLPLLGEQAADGHAPVRGLIGLLTQRVFDYTSGAREDRPPREEELPLIEEARNRLIEGIISESEDESLMERYLGGEDVEVKTLVQDLEKAVARGVFHPVLAAAPAADGGTQGLGTVELLELITGGFPTPLERRIPDVTTVRGEKRPGLACDPAGPLAAEVVRTSSDPYIGRLSLLRVFSGTLRPDQTVHVSGHGMEDRGHEDHDTDERIGSLTAPFGKLQRPLDAAIAGDIACVGKLNGAETGDTVSAKDEPLLMAPWVMPDPLLPVAIEAHTKQDEDKLSQGLARLCAEDPTMRLEQNASTRQLVLWCLGEAHRDVALERLRTRYGVQVDSVDHKVSLRETFSGRSAARGRHVKQSGGHGQYAICEIEVEPLPEGSGIEFVDKVVGGAVPRQFIPSVEKGVRGQAVKGVATGYPLVDVRITLVDGKAHSVDSSDAAFQTAGALALREAAAQVQIHLLEPVAEIGVLVADEYVGPVMSDLSGRRGRVVGTEQAGGGRTLVRAEVPEFEIGRYAVDLRSLSHGTGRFDRSYARHEPMPQQLAAKIRDRQARDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MYW4</accession>
    <name>A0A0F7MYW4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Extracellular small neutral protease</fullName>
            <ecNumber evidence="4 6">3.4.24.77</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AA958_00775</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>Hydrolyzes proteins with a preference for Tyr or Phe in the P1' position. Has no action on amino-acid p-nitroanilides.</text>
            <dbReference type="EC" id="3.4.24.77"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="8">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 6">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the peptidase M7 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.77" evidence="4 6"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH80941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014307.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH80941">
        <property type="protein sequence ID" value="AKH80941"/>
        <property type="gene ID" value="AA958_00775"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_00775"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.175"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000013">
        <property type="entry name" value="Peptidase_M7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02031">
        <property type="entry name" value="Peptidase_M7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016573">
        <property type="entry name" value="Peptidase_M7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00787">
        <property type="entry name" value="NEUTRALPTASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="6 8" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014495520" description="Extracellular small neutral protease" evidence="6">
        <location>
            <begin position="27"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="141"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR016573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR016573-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR016573-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR016573-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AKH80941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="190" mass="19355" checksum="8CF19A4BC2BF62DD" modified="2015-07-22" version="1">MLRKLGIGVMAAAAIVTLSSAPGATAAPAPAPERTAVATTLYYDDSQAGEFKGAVAAGAEQWNSTVQNVKLAKAPAGTRAEITVIADDGWPRATLGPVRPGGRATVWFGRQAVNEGYNTTRIAAHELGHSLGLPDRKPGPCSSLMSGSTAGVSCTNPVPNATERAQVEANYGGGFASLVPMDGRIVVDAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MZH9</accession>
    <name>A0A0F7MZH9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_01835</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014480.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_01835"/>
    <dbReference type="EnsemblBacteria" id="AKH81116">
        <property type="protein sequence ID" value="AKH81116"/>
        <property type="gene ID" value="AA958_01835"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_01835"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.399"/>
    <dbReference type="OrthoDB" id="1970151at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH81116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="109" mass="12077" checksum="33F9EE8F8D84E3D6" modified="2015-07-22" version="1">MAETEYTARGVRIGRWLRSLTRAGQVHIKDGRLELLTSYGTQIDSAPVEEVRAARPWFGRGDRAVASVNGRQYVLTLTGEQGWQEESGEKAAGRFLEAVRAARGRPDFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MZZ5</accession>
    <name>A0A0F7MZZ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_06280</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015233.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH81880">
        <property type="protein sequence ID" value="AKH81880"/>
        <property type="gene ID" value="AA958_06280"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_06280"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1313"/>
    <dbReference type="OrthoDB" id="1833499at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="1"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="26"/>
            <end position="33"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH81880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="231" mass="24633" checksum="00959583F0D6186C" modified="2015-07-22" version="1">MRRISCSANFEGIDYELNPGVTILLGPNGAGKSTLLRLAAGVAQPTKGAIALDGIPSGDRSYRRTVAWMPQNIPVMAGLTAREQVAYVGWLKGMSKSSAWESASDALAQVELSAQENVKMNRLSGGQVRRIGIASAMVHGAKVLLLDEPTAGLDPTQRRQFRTHLTDLRPDVRVMMSTHDVTDLAEESDHVAVLSTGRLVFEGPTNAFLAHAPSDVAPGRRAEAAYSALTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N007</accession>
    <name>A0A0F7N007_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zinc-binding alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_02845</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014649.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_02845"/>
    <dbReference type="EnsemblBacteria" id="AKH81286">
        <property type="protein sequence ID" value="AKH81286"/>
        <property type="gene ID" value="AA958_02845"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_02845"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.608"/>
    <dbReference type="OrthoDB" id="972769at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADH_N" evidence="2">
        <location>
            <begin position="58"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="ADH_zinc_N" evidence="1">
        <location>
            <begin position="216"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH81286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="412" mass="43355" checksum="75D6C0B3E5D82805" modified="2015-07-22" version="1">MSLALQYHRSPARFLAARGLSRTRSRAAGSLAGSLAPLRLTRDRRELPKGDGWTRLAPSLSGICGSDLGMLNGTVSPYLAALTSTPFVPGHEVVGTTVDDLPTIPRGTRVVLDPVLSCAVRGLPECDACRAGHTNRCDHITSGHLSPGMQTGYCADTGGGWAQRMVAHEHQLRPVPDDLPDERAVLVEPLACAIHSVRRVPIEPGASVLVIGAGTVGLFTVLALRQLTEAGTIHVVAKHGHQRERALALGADEAVEPDRALRAVRRMTSALAQRPEMGSEFLLGGADIAFECTGGGAGLDTALRTVRAGGTVVVSGIPGGADLTPLWYRELSLVGAYTTRRREDVTPDDPDAGPDGRAGTDFDKAVQLAATAPLDGYVERYALQQWRPALEHAFAAGSAGSVKIAFDPTLDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0T7</accession>
    <name>A0A0F7N0T7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-oxoacyl-ACP reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_01250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014383.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_01250"/>
    <dbReference type="EnsemblBacteria" id="AKH81018">
        <property type="protein sequence ID" value="AKH81018"/>
        <property type="gene ID" value="AA958_01250"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_01250"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.273"/>
    <dbReference type="OrthoDB" id="1601931at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH81018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="252" mass="25512" checksum="09D87C5C0FBCC375" modified="2015-07-22" version="1">MSTTGRVAIVTGAARGIGAATAVRLAHEGRAVAVLDLDEGACAETVGKITEAGGTALAVGCDVSDAAVVEAGVARAAAELGPPVILVNNAGVTRDNLLFKMAEEDWDTVMNVHLRGAFLMSRACQKHMVDAGFGRIVNLSSSSALGNRGQVNYSAAKAGLQGFTKTLAKELGKFGVTANAVAPGFIATEMTAQTAARVGMDFADFQAAAAAQIPVQRVGQPDDIAGAIAFFTGEDAGFVSGQVLYVAGGPLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N125</accession>
    <name>A0A0F7N125_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_01570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0749 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014433.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_01570"/>
    <dbReference type="EnsemblBacteria" id="AKH81069">
        <property type="protein sequence ID" value="AKH81069"/>
        <property type="gene ID" value="AA958_01570"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_01570"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.345"/>
    <dbReference type="OrthoDB" id="1883872at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010273">
        <property type="entry name" value="DUF881"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37313">
        <property type="entry name" value="PTHR37313"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05949">
        <property type="entry name" value="DUF881"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="277" mass="29562" checksum="778D13AED175C34F" modified="2015-07-22" version="1">MSLLTRLMDHSLDDGYAEAAARHGARPRGERLPQRLRGRAWLAAGLVLTALVLTVGAAEARIEAPDLAREREELIERVEDRTAAADDLDRAVERLHGEVADRQREALEENGSDQAALLALLAGAAEARGPGVRLVVDDAADAGTGATGGPRSSTSFADDGRVRDRDLQRIVNGLWLAGAEAVSVNGRRLTALSAIRAAGDAILVDNRPLAPPYTVLAIGDGEALLERFRENADGHYLDVLRDNYGIRAGVSARDDLRLPAATGLSLRHAEPKENNPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N194</accession>
    <name>A0A0F7N194_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Carbohydrate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_02230</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014547.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_02230"/>
    <dbReference type="EnsemblBacteria" id="AKH81183">
        <property type="protein sequence ID" value="AKH81183"/>
        <property type="gene ID" value="AA958_02230"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_02230"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.479"/>
    <dbReference type="OrthoDB" id="1619686at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008993">
        <property type="term" value="F:rhamnulokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019301">
        <property type="term" value="P:rhamnose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07771">
        <property type="entry name" value="FGGY_RhuK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013449">
        <property type="entry name" value="Rhamnulokinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0684">Rhamnose metabolism</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FGGY_N" evidence="2">
        <location>
            <begin position="23"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="FGGY_C" evidence="3">
        <location>
            <begin position="271"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH81183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="504" mass="52200" checksum="450F8CFB288B00D3" modified="2015-07-22" version="1">MSRAYGPGTGGGGADGNSLPFAAVDLGAASGRVMLGRAGGGELHIEEVHRFPNRPVRLAGTLHWDVLALYAGVLEGLRAAGRRSGGGLAGVGVDSWAVDYGLLDASGALIGNPVHYRDARTEGMAAKLAAVLPAAELYRATGLQHLPFNTVYQLLAARGTPALAAARRLLLIPDLVAYWLTGEAGTELTNASTTALVDPRTGAFSRRVAEAAGVDLGLFPPLRRPGDPAGELLPAVLEETGLTGPVPVTAVGSHDTASAVVGVPARDADFAYIATGTWSLAGVELPAPVLTEESRAANFTNELGVDGTVRYLRNIMGLWLLQECLRAWDAEGHTYELDALLAGAAAAPPLRSYVDAGDPAFLAPGRMPERIAAACRRAGRPEPRSAAETVRCVLDSLALAHRRAVADAQRLSGRTVRVVHVVGGGARNGLLCRLTADACGLPVVAGPVEAAALGNVLVQARAAGVIDGTLPDLRSLLHRTQPLREYEPGGGSAWEEAECALRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N1S6</accession>
    <name>A0A0F7N1S6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Lipid A biosynthesis acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_03330</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014732.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_03330"/>
    <dbReference type="EnsemblBacteria" id="AKH81373">
        <property type="protein sequence ID" value="AKH81373"/>
        <property type="gene ID" value="AA958_03330"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_03330"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.708"/>
    <dbReference type="OrthoDB" id="1106624at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009247">
        <property type="term" value="P:glycolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd07984">
        <property type="entry name" value="LPLAT_LABLAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004960">
        <property type="entry name" value="LipA_acyltrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30606">
        <property type="entry name" value="PTHR30606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03279">
        <property type="entry name" value="Lip_A_acyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH81373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="296" mass="32452" checksum="C946F4BB4EA0F587" modified="2015-07-22" version="1">MRERLTDGVYGLGWAAVKRLPEPAAAALGRRIADTAWRRDGKGVRRLTSNLARVVPDAGPERLAELSRAGMRSYMRYWMESFRLPAWSKQRIRDGFDPQDVHWLEDGLAGDTGVILALPHMGNWDLAGAWVTTKLGVPFTTVQERLKPESLYDRFVVYRESLGMEVLAHGGASAFGTLARRLRGGGLVCLVADRDLSATGVEVDFFGSAARMPAGPALLAQQTGALLLPVTLWYDDSPVLQGKVHAPVEVPSTGTRAEKTAAMTQAMADDFAAGIAGHPEDWHMLQRFWLADLESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N1X8</accession>
    <name>A0A0F7N1X8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_10605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015941.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_10605"/>
    <dbReference type="EnsemblBacteria" id="AKH82600">
        <property type="protein sequence ID" value="AKH82600"/>
        <property type="gene ID" value="AA958_10605"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_10605"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2231"/>
    <dbReference type="OrthoDB" id="1793376at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="18"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="226"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="403" mass="42118" checksum="A1F8911B30DBBF80" modified="2015-07-22" version="1">MRSELLADDAWALLRGGRRAVLGLAGAPGAGKSTLARALVAALRARHGAGAAAYVPLDGFHLSNAQLDRLGLRDRKGSEPSFDAAGYAALLRRLAEEPGAEVYVPDFDRALDEPVAARHHVPPGTRLIVTEGNYLACDLPGWRAARELMAEVWYVDAPDAVRDARLMARHVGFGRTAAASRAWIDANDAPNAELVKASRGRCDRVVAADDPAAGPAEAADAPGHPPGDVLVVSGPPGAGKTTVARLLAREAEPSVHLHTDDFWAFIARGGIAPYLPAARRQNETVVAVAAGAAARYAAGGYRVVLDGVVGPWFVDAYRAAARAAGVPLHYVVLRPDEPTALARATARTGPDALTDPGPVRAMHREFADLGPYETHALDTGGQPPEATAAAVRDAVAAGTYRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N1Y8</accession>
    <name>A0A0F7N1Y8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_10665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015951.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_10665"/>
    <dbReference type="EnsemblBacteria" id="AKH82610">
        <property type="protein sequence ID" value="AKH82610"/>
        <property type="gene ID" value="AA958_10665"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_10665"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2243"/>
    <dbReference type="OrthoDB" id="1552415at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010390">
        <property type="entry name" value="DUF990"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06182">
        <property type="entry name" value="ABC2_membrane_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="271" mass="28773" checksum="D3E417B3FA809018" modified="2015-07-22" version="1">MADLAAGVRGYGLIVAMWVRTTMTYRMSFAMTALGNLLMTAADFAAIAIMFSHTDVLGGFTFAEVGLLYGTTSTSLGLADLLLGNLDRIGSRIRDGTMDTLLVRPVPVFAQIAADRFALRRIGRVLQGLIVLVWSLTALEGVAWTPVAVLLVPVMVLSGAAIFGAVFACGAAFQFWATDAAEVQNSFTYGGNTLTQYPPTIFSKELVRGVTFAVPLAFVNWLPALHILGRDDPLGLPGWVDFASPLVAAACCALAGLAWRTGLRGYRSTGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N207</accession>
    <name>A0A0F7N207_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_07055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015366.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH82016">
        <property type="protein sequence ID" value="AKH82016"/>
        <property type="gene ID" value="AA958_07055"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_07055"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1477"/>
    <dbReference type="OrthoDB" id="2200654at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="225" mass="24439" checksum="68B84E5E0B472249" modified="2015-07-22" version="1">MAAVVLGVSGCEDVREPDSSVLRESPTPCASWSPEHTPEPPHITRLAYRAEEFEDGSLAMTVGDVDAAPEDPSAVRTVDYRQPAAVTECETVRIETVSGWWCTTTVEPIAVEGEIVVGGAAPRAEIGGEGFATECHGELPGRMRQVYALERDSWSGWRDYGDSRHTSWTRSRSQQGPRVTELCPQGRTGTYNYRLAVRVEVDSVTVGESWAASPHIRTDCGTGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N228</accession>
    <name>A0A0F7N228_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AA958_00665</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNQ-509</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH80922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014288.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_00665"/>
    <dbReference type="EnsemblBacteria" id="AKH80922">
        <property type="protein sequence ID" value="AKH80922"/>
        <property type="gene ID" value="AA958_00665"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_00665"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.153"/>
    <dbReference type="OrthoDB" id="1123553at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033068">
        <property type="term" value="P:macrolide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041618">
        <property type="entry name" value="PKS_DE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015083">
        <property type="entry name" value="Polyketide_synth_docking"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08990">
        <property type="entry name" value="Docking"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18369">
        <property type="entry name" value="PKS_DE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="2 7" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="1492"/>
            <end position="1567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1616"/>
            <end position="1661"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="7">
        <location>
            <position position="1527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AKH80922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="1661" mass="173255" checksum="A0ECC288D39F956D" modified="2015-07-22" version="1">MASSNEEKLRDYLKAVTADLRQTRQRLQSLEERDHEPIAVVGMACRYPGGAVSPDALWELVSAGGDAIGEFPADRGWDLEAVFDADPDKAGTSYARRGGFLYDLPEFDAGLFGVSPREAAAMDPQQRLLLELAWEALERAGIAADGLRGSATGVFAGTSAADYGPRLHEATAGAEGYMLTGTTPSVASGRIAYTLGLEGPALTVDTACSSSLVAVHLATRALRARECTMALAGGATVMSTPGMFVEFSRQRGLASDGRCKSFSDDADGTGWSEGAGMLVLERLSDARAAGHPVLAVIRGSAVNQDGASNGLTAPNGPAQQRVIAQALADARLTARQVDAVEAHGTGTSLGDPIEAQALLATYGREHSAEQPLWLGSVKSNIGHTQTAAGVAGIIKMVQAMRHGRLPRTLHSETPSRHVEWAGGGVALLAEEVDWPESDRPRRAAVSAFGISGTNAHVILEEGPPPAEPAERSGEGGPRTALWTLSARTGEALRARAAELAEAVRTEEPPAAGDVGWSLATTRAAFDERAVVLGGDTAELAEGLAALAADRGSPRVVRGSAVSGAARPVFVFSGQGAQWPGMAVGLWDSEPVFAASMERCAAALAPYTGYTLREKLTAPADDAAWERDDVVQPLMWAVMVSLAELWRHHGVTPAAVVGHSQGEFAAAVAAGALSLEDGARLVAVRSRVVHALSGHGSMASVSLPVAEVEKRLAETGGDVGVAAVNGPSATVVAGVDADVRAFMRDCEEQGVRTRTVPIAYASHSPLVEPVREEMLRELAAITPRAGEVPFYSTVTGEPMPTESLDAAYWYRNLRSPVLFAQTVERLMDAGHTVFLEMGPHPVLVPAIEQVLDATETDGRALGTLRRDEDGEPRFKQALAEAYAAGVVPDWQVLFPDARTVPLPTYPFQRRRYWLADRDDRAPRAAQTRAGGSDEAFWALVEQADTEALRRELPEVGEDALRAVVPALHRWRSRTRTDAALAGQRYEIGWRPAAERRTPGPDGHWLLVTRTGAAGRLADWADAAGAALSARGAGVTVVELDERADDERAGIARRLSAALAGEAVDGVLSLLPLDERPHPGHAALPSGVGGLLGLVQALAGLGVAAPVWSLTCAAVKALDDDVLAHPEQAETWGLGRVVALEQPQLWGGLVDLPERPGDEDWLRLCAVLAGGAGDEDQVAIRPGGPRVRRLLPAPAPADSPVWQPGGTVVVTGGSGSLAPHLARWLADGGAEHIVLASRRGPDAPGHEALAAELAGRGVGVTALSCDLTDRDSVRALLRRAAELGGPVRAVVHAATSTRLEPLADATAAGVAEVLAAKALGAVHLAESMDPDGPAELVFFSSIAAVWGSGEHGAYAAANAFLDAYAQQLRGRGRKVTSVAFGAWRSEVLPEGLDEAQLERQGLPLLDPELALAGLGREVAGAGGGRPVTLVDVDWETFAPVFASARPRPLLDEIPAVRGALRRSAEAGGTGAADGGDTGERLRKLAGLPEAARGREVLDVVTAEVAAVLGHSPADRPAPMRTFKELGFDSLTAVALRNRLRAATGLSLPVTLVFDHPSPQALARFLTGQLGTAGEQAAPGSVHEELDRLAAALDAAPVEGAERAAVRDRLQALAAALAGGGTAASGRGEDDDADLDDASTDDLLKIIDDEFGPAEPGPTASTTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N234</accession>
    <name>A0A0F7N234_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CRISPR-associated protein Cas2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_03720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014802.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_03720"/>
    <dbReference type="EnsemblBacteria" id="AKH81444">
        <property type="protein sequence ID" value="AKH81444"/>
        <property type="gene ID" value="AA958_03720"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_03720"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.783"/>
    <dbReference type="OrthoDB" id="1761252at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010152">
        <property type="entry name" value="CRISPR-assoc_prot_Cas2_sub"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09707">
        <property type="entry name" value="Cas_Cas2CT1978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01873">
        <property type="entry name" value="cas_CT1978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="115" mass="13039" checksum="37D48F4BE6CBA26C" modified="2015-07-22" version="1">MTVIVLSNCPVGLRGFLTRWLLEVSPGVFVGRPSARIRSALWAAVEEHAHEGRALLTYTTDTEQGYTFESLDHQWQPEDHEGITLIRRPTAQPTAADRPPRQGWSTAAKRRRYAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N242</accession>
    <name>A0A0F7N242_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-lactamase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_11010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016008.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_11010"/>
    <dbReference type="EnsemblBacteria" id="AKH82670">
        <property type="protein sequence ID" value="AKH82670"/>
        <property type="gene ID" value="AA958_11010"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_11010"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2319"/>
    <dbReference type="OrthoDB" id="1439085at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="361" mass="38181" checksum="64B70660306164D2" modified="2015-07-22" version="1">MTLRQRVQDVLDELVAGGAETGVQVAVHHRGRRVVDAVAGVADGTTGRPVTPETLFFSFSTAKGVTALLAHLLVRDGLIGYDTPVAEVWPEFGTHGKETATLRQVLTHTVGVPAMPGGIGPADLADWPRICAALAGAEPRWRPGTRTGYHSFTFGFLVGEIARRVTGQPVRRLLHDWIASPLGIAGELYFGVPPAEFARLARLEDAEPQPAEPAEHDGLLAPWERQPRASMGNDPGFLQADVPSVGTFTARGIATVYAAVLDGRLIAAEQLEELTAVAFEGTDQVFGNPARLALGYPLGRLGAPADEAPTTFGWPGGGGSYAYADPATETSFAVTKNRLTPDFATAQRLSAVVTAEFGLLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2B6</accession>
    <name>A0A0F7N2B6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Polyketide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_04220</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014884.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_04220"/>
    <dbReference type="EnsemblBacteria" id="AKH81529">
        <property type="protein sequence ID" value="AKH81529"/>
        <property type="gene ID" value="AA958_04220"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_04220"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.885"/>
    <dbReference type="OrthoDB" id="1943389at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901362">
        <property type="term" value="P:organic cyclic compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="11"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="3">
        <location>
            <position position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH81529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="91" mass="9908" checksum="DEFDF894AC2D8A4C" modified="2015-07-22" version="1">MSELTTETSQSAVAEVIDWLRDRVAAQTGRPAAEIDPDVPLNDYGLDSVYLFGLSAEIEDHYGIEVEATIMWDNTSLAPLADALMPLIAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2C1</accession>
    <name>A0A0F7N2C1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-ketoacyl-ACP reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_01245</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014382.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_01245"/>
    <dbReference type="EnsemblBacteria" id="AKH81017">
        <property type="protein sequence ID" value="AKH81017"/>
        <property type="gene ID" value="AA958_01245"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_01245"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.272"/>
    <dbReference type="OrthoDB" id="1294334at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH81017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="260" mass="26901" checksum="7551753A8FACB7B5" modified="2015-07-22" version="1">MTQQERAGVPQAAESGRVALVTGASRGIGYGIAEALVARGHRVCVTGRGEEALQEAVARLGAGRAIGVPGKAHDEAHQAEAVARTMEAFGRVDYLVNNAGTNPVFGPIADVDLNAVRKVYETNVLSALGFAQQTYKAWQREHGGAIVNVSSVAGLSASPFVGAYGMSKAAMINMTLQLAHEFAPAVRVNAIAPGVVKTKFAVALYEGREEEAAAGYPLGRLGVPEDIGGAAAFLLSDEAGWITGQTLAIEGGIFLNAGWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-08-12" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2G1</accession>
    <name>A0A0F7N2G1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH araC/xylS-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_01445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014412.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH81047">
        <property type="protein sequence ID" value="AKH81047"/>
        <property type="gene ID" value="AA958_01445"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_01445"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.318"/>
    <dbReference type="OrthoDB" id="1268974at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="167"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="277" mass="29024" checksum="862C76ADFD8159D9" modified="2015-07-22" version="1">MAVIRHPLLTADDLCVADVRCDDPPAGWTPLRAADVFGLVLVRDGVVRARVDGVEQTMDPASVYVERLGSEQQFAHPRGADRYTELVPSEPLLASLLGGDPAVPEGLVFTTPAMALRHRLLCASAGRGPRDAFGAAESAVALTAAALAQLDARRVASGAPATAAARRRLADSAREALAADPRLGLLTLAAELGCSPHHLSRVFRAVTGATLSRYRNRLRAARALECLAAGERDLGGLAAALGFADQAHMTHVVRAESGLPPGRLRTLLAPAAPPRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2K2</accession>
    <name>A0A0F7N2K2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Error-prone DNA polymerase</fullName>
            <ecNumber evidence="2">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">AA958_04730</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase type-C family. DnaE2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="2"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014969.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_04730"/>
    <dbReference type="EnsemblBacteria" id="AKH81614">
        <property type="protein sequence ID" value="AKH81614"/>
        <property type="gene ID" value="AA958_04730"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_04730"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.997"/>
    <dbReference type="OrthoDB" id="561611at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011708">
        <property type="entry name" value="DNA_pol3_alpha_NTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041931">
        <property type="entry name" value="DNA_pol3_alpha_thumb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040982">
        <property type="entry name" value="DNA_pol3_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023073">
        <property type="entry name" value="DNA_pol_error_prone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029460">
        <property type="entry name" value="DNAPol_HHH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004805">
        <property type="entry name" value="PolC_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32294">
        <property type="entry name" value="PTHR32294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32294:SF4">
        <property type="entry name" value="PTHR32294:SF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07733">
        <property type="entry name" value="DNA_pol3_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17657">
        <property type="entry name" value="DNA_pol3_finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14579">
        <property type="entry name" value="HHH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00594">
        <property type="entry name" value="polc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="POLIIIAc" evidence="12">
        <location>
            <begin position="5"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1102"/>
            <end position="1153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AKH81614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="1153" mass="124021" checksum="49C4F13C40F248AB" modified="2015-07-22" version="1">MVGFAHVHVASGYSARYGAAHPEHLVRRAAERGMGALALTDRDTVTGAVRFVRACAGAGVRPVLGVDLAVAGVAPPPPALRRRTPARGGGHVVEPPLRFVLLARDGAGWARLCRIVSAAHAGATGGSPPVVPWQALREHGGPGLVALLGPLSEPVRALAVGREDVAARLLAPWREVFGAGLRLEAVAHKRAGLGPGSLRLAARTLALGDRTGTTVVLSNAVRYADPGQHRLADVLDAARLLRPIDWRRLDSGQRWLKDERAMAAVARLVAECAGADVRRARRLMADTAATAAACTIDPGADLGLGRPHFPEPALFGAGPGADGAARLLRRRCEAGMARRGLDRDPEARTRLDEELKAISTLRYDSYFLAVGQVVADIRAKGIRVAARGSGAGSLVCHVLDIATANPLDHRLLFERFLSVRRTSLPDIDIDVESARRLECYDVIFDRFGKERVAVTAMPETYRARRALRDAGLALGIAPADVDRIAKSFPHLRAADITGALAELPELRQLAAEAHRYGPLWELAEGLDALVHGMAMHPCGVVISDATLLDRLPVQPTPQGDYPMAMAAKEEIEDLGNIKLDVLGVRMQSAMAHAVAEIAQATGDHIDLDDPGQVPLDDVFAFKLIQDSETLGLFQLESPGQQDLLSRLKPRDPQDVIADISLFRPGPVAGGMPERYVAARHGGAPEYAHPDLEPVLSDTYGVTIWHEQIIETFRVMTGCDRALGEIARRALGDEDRLPRIRDWFHRRARARGYTTAVRDEVWKTVAAFGAYGFCRAHAVAFAVPALQSAWLKAHYPAFLLAGLLEHDPGMWPKRVLVSDARRRGVPLLPVDVNRSKVKHTVEKTDTDRWGVRLALAAVHGISEDEGVRIEEGQPYASLSDFWQRARPSRPVAERLARIGALDGLGGPDDGRSTRRDLLLQIDELHRQSRARFAADGQLPLGTDAVGGTEPSGLPEMTGRETLSAELDTLGIDVSKHLMEHHHRLLREIGATDAAHLAGLRPGQQVLVAGVRASTQTPPIASGKRIIFVTLEDGSGLVDLAFFEDSHPACAHTVFHSGLLLVRGTVQVRGTRRTVVGTMAWDLDRIAAARRDDGPEAALALLGEDRPHPTPAQPGRALTDGTAGARLHPYADLQPAGSRSADLKKLGHRSPGSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2U1</accession>
    <name>A0A0F7N2U1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycosyl hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_02110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014526.1">
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH81162">
        <property type="protein sequence ID" value="AKH81162"/>
        <property type="gene ID" value="AA958_02110"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_02110"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.454"/>
    <dbReference type="OrthoDB" id="1293876at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH81162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="360" mass="38528" checksum="E4B96860FD7F7950" modified="2015-07-22" version="1">MQDVVLAVGTRKGLFLGRRRGGAWELDGPHFRAQAIYSVGIDTRGAAPRVLAGGDSSHWGPSVFHSDDLGATWEEPGRQPVKYPKDTGTSLERVWQLQPAGAEAPGVVYAGTEPGGLFRSQDGGETFELMRSLWDHPTREKWEPGGGGLAVHTVVTDPRDARSVTVAVSAGGVYRTVDGGASWAPSNSGVQVVFQPERFPEFGQCVHKVARDAVDPDRLYLQNHWGVYRSDDAGATWTDIGAGLPSDFGFAVAAHPSRGNTAYLFPITADADRVPAGNRCRVYRTSDAGATWEPLSAGLPAEDHYGTVLRDALCTDDADPAGVYFGNRNGEVFASADEGERWTQLAAHLPDVLCVRAAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3E8</accession>
    <name>A0A0F7N3E8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_06205</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_06205"/>
    <dbReference type="EnsemblBacteria" id="AKH81868">
        <property type="protein sequence ID" value="AKH81868"/>
        <property type="gene ID" value="AA958_06205"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_06205"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1298"/>
    <dbReference type="OrthoDB" id="1020672at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="2"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="124"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="124"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH81868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="234" mass="25540" checksum="5270B377224F2F2B" modified="2015-07-22" version="1">MRVLIVEDEPFMAEAIRDGLRLEAIAGDIAGDGDTALELLGVNSYDIAVLDRDIPGPSGDEIARRIVDSGSGMPILMLTAADRLDDKATGFGLGADDYLTKPFDIRELVLRLRALDRRRAHIRPPVREIAGLRLDPFRREVYRDGRYVALTRKQFAVLDVLVAAEGGVISAEELLERAWDANADPFTNAVRITVSALRKRLGEPWLIATVPGVGYRIDTGSGGEDEESGTADRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3H1</accession>
    <name>A0A0F7N3H1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Acetyl-coenzyme A synthetase</fullName>
            <shortName evidence="5">AcCoA synthetase</shortName>
            <shortName evidence="5">Acs</shortName>
            <ecNumber evidence="5">6.2.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Acetate--CoA ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Acyl-activating enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">acsA</name>
        <name evidence="9" type="ORF">AA958_14395</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>acetate + ATP + CoA = acetyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23176"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="PTM">
        <text evidence="5">Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.1" evidence="5"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016541.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_14395"/>
    <dbReference type="EnsemblBacteria" id="AKH83225">
        <property type="protein sequence ID" value="AKH83225"/>
        <property type="gene ID" value="AA958_14395"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_14395"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3029"/>
    <dbReference type="OrthoDB" id="141801at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003987">
        <property type="term" value="F:acetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019427">
        <property type="term" value="P:acetyl-CoA biosynthetic process from acetate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01123">
        <property type="entry name" value="Ac_CoA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011904">
        <property type="entry name" value="Ac_CoA_lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02188">
        <property type="entry name" value="Ac_CoA_lig_AcsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACAS_N" evidence="8">
        <location>
            <begin position="31"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding" evidence="6">
        <location>
            <begin position="91"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="7">
        <location>
            <begin position="532"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Coenzyme A binding" evidence="5">
        <location>
            <begin position="193"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="312"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="388"/>
            <end position="390"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="412"/>
            <end position="417"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="501"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="516"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="524"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="538"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="540"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="543"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-acetyllysine" evidence="5">
        <location>
            <position position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH83225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="651" mass="71264" checksum="5F6B1C924B5BACC1" modified="2015-07-22" version="1">MSNESLANLLKEERRFEPPAELAAHANVTAEAYEQARADRLGFWAEQARRLSWATEPTKTLDWSDPPFAKWFEDGSLNVAYNCVDRHVEAGLGDRVAIHFEGEPGDSRSITYAELQRDVAKAANALTELGVQTGDRVAVYMPMIPETVVAMLACARIGAPHSVVFGGFSADALATRIADADARVVITADGGYRRGKPSALKPAVDDAVGRTDRVRNVLVVRRTGQDVAWTEGRDVWWHDVVDRQEDTHTPEAFPAEHPLFILYTSGTTGKPKGILHTTGGYLTQVSYTHHAVFDLKPETDVFWCTADVGWVTGHSYIVYGPLSNGATQVLYEGTPDTPHQGRWWEVIQKYKVSIFYTAPTAIRACMKWGDAIPAKFDLSSLRLLGSVGEPINPEAWIWYRDHIGAGRTPVVDTWWQTETGGIMISPLPGVTSTKPGSAQVPLPGIAATVVDDEAREVPDGSGGYLVLTEPWPSMLRTIWGDDQRYKDTYWSRFEGRYFAGDGAKKDDDGDIWLLGRVDDVMLVSGHNISTTEVESALVSHPKVAEAAVVGATDPQTTQAIVAFVILRGGAEEAEGLVEELRAHVAKALGPIAKPKRILPVAELPKTRSGKIMRRLLRDVAENREMGDVTTLTDSTVMDLIQAKLPSAASED</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-08-12" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3L3</accession>
    <name>A0A0F7N3L3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_10795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015971.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH82631">
        <property type="protein sequence ID" value="AKH82631"/>
        <property type="gene ID" value="AA958_10795"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_10795"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2270"/>
    <dbReference type="OrthoDB" id="1459004at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="248"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="359" mass="37671" checksum="26AB79E91CAE5915" modified="2015-07-22" version="1">MTGSAETSPTGPHRVAVLVRDGVMPLELGLVHQMFGSAEAGGRRLYEVVTCALRPGPVRTDADFPVLVERGPEALDGAATVVVPASHAADAVESAVGSAVGSAGDAGEGPAGGAGYGEPSAALRAALGRVRPDARVASVCTGAFVLAAVGLLDGRRATTHWKSAELFRRRFPAVRLQPDVLYTEDRGVLTSAGEAAGIDLCLHMIRADHGAAVANDVARRTVVPPHRDGGQAQYVPRPVAEPELGTTGRARAWALAHLDRPVALRELAAQESMSVRTFSRRFREETGVTPLQWLTRQRVERARHLLEETDRSVDRVAADAGFGTAASLRQHMQAALGVSPTAYRGTFRGPGQLPAGTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3T0</accession>
    <name>A0A0F7N3T0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_15000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AHA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016625.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_15000"/>
    <dbReference type="EnsemblBacteria" id="AKH83310">
        <property type="protein sequence ID" value="AKH83310"/>
        <property type="gene ID" value="AA958_15000"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_15000"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3161"/>
    <dbReference type="OrthoDB" id="1914312at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013538">
        <property type="entry name" value="Activator_of_Hsp90_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08327">
        <property type="entry name" value="AHSA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="163" mass="18334" checksum="DA1B0083D13A9AB3" modified="2015-07-22" version="1">MNDIAYTDAELAELDRVARRIDIDAPADRVWDLVVRPGWYINEGEVDPEPDLSYDGDVAVVRGDRLGEFRFSTVELDKPRYAAFRWLTGRSQPGAKGSTLVEFWIDERPGGVTLRVVESGFSRLFDERSAWLKEREGNDVGWAEELAAGKRYVEKAAAAAPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3X6</accession>
    <name>A0A0F7N3X6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Molecular chaperone DnaJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_04440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014917.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH81562">
        <property type="protein sequence ID" value="AKH81562"/>
        <property type="gene ID" value="AA958_04440"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_04440"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.935"/>
    <dbReference type="OrthoDB" id="1950808at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018961">
        <property type="entry name" value="DnaJ_homolog_subfam-C_membr-28"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09350">
        <property type="entry name" value="DUF1992"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1992" evidence="1">
        <location>
            <begin position="14"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="135" mass="15273" checksum="4624F84E3125C437" modified="2015-07-22" version="1">MTERKPPGVSFESWIDRQIREAAERGEFDDLPGKGKPLADLDRPYDELWWVKAKMAREQLSALPPSLAVRKEAEAALAAVTRARSEREVREIVAEVNEKIRAAHRAPAVGPPLRLAPLDADTLVREWREGREGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3Z5</accession>
    <name>A0A0F7N3Z5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SpdA protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_15370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016673.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_15370"/>
    <dbReference type="EnsemblBacteria" id="AKH83360">
        <property type="protein sequence ID" value="AKH83360"/>
        <property type="gene ID" value="AA958_15370"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_15370"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3233"/>
    <dbReference type="OrthoDB" id="1461964at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021235">
        <property type="entry name" value="DUF2637"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10935">
        <property type="entry name" value="DUF2637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519019" evidence="2">
        <location>
            <begin position="33"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH83360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="197" mass="20645" checksum="B12891FB7807F467" modified="2015-07-22" version="1">MRDRLARVDPVLVQAVIAAALSFAHLHDVASAAGQDGWKAWAYPVSVDLLLVAAWRRLRSGRDKAAAWCWFLIALAASLGANIATAGVLDLNDVPDWLRILVAGWPALAFLGGTLLAHSPAPKPVLDEAAPEPAPVAEAPATSELPAAPVPAALIEHARKVAAAHESRTGTRIDPDTLRARLGVPAPLADRIAAQLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4F4</accession>
    <name>A0A0F7N4F4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_08425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AHA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015603.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_08425"/>
    <dbReference type="EnsemblBacteria" id="AKH82254">
        <property type="protein sequence ID" value="AKH82254"/>
        <property type="gene ID" value="AA958_08425"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_08425"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1779"/>
    <dbReference type="OrthoDB" id="1914312at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013538">
        <property type="entry name" value="Activator_of_Hsp90_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08327">
        <property type="entry name" value="AHSA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="160" mass="17676" checksum="7FF7B7E6A198F002" modified="2015-07-22" version="1">MTASPADTTVPLVVRDLPAPPPLVHRAWTEADLLARWIGPRGYTVPRDTVTVEPYVGGHFDYCMVDAADDTEGDTTDRGRHWLRNHITELAAPHLLVLTSAPMPEYGTPAPVSTRIHLAPALPGTRLTFTRTYPPERRPTARATWTTSFDNLEALLLTLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4G1</accession>
    <name>A0A0F7N4G1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MerR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_12195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_12195"/>
    <dbReference type="EnsemblBacteria" id="AKH82871">
        <property type="protein sequence ID" value="AKH82871"/>
        <property type="gene ID" value="AA958_12195"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_12195"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2565"/>
    <dbReference type="OrthoDB" id="1467120at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="4"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="256" mass="28498" checksum="4F2BE13280CDBF77" modified="2015-07-22" version="1">MGREYRTEELAERAGITVRTLRFYRERKLLQPPRREGRIAWYGEGHLSRLRTIAALLDRGHTLGGIAELISAFESGRDVRGAAELLGLEETLTKPWSEETPVRITPEELADRFAGEVSPENLATSIDMGYVAVEGEEFIHVSRRLLDASSKLVARGVPLAAVLAAAREVRAHADDLAELFTALIRAHVLADVMETPAGELTGEQVERLTDALEQLRPVSMDVLEAEVAMAMDRRVRKEFEEWKRTRAGSTAEEPEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4W1</accession>
    <name>A0A0F7N4W1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_06065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015195.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_06065"/>
    <dbReference type="EnsemblBacteria" id="AKH81842">
        <property type="protein sequence ID" value="AKH81842"/>
        <property type="gene ID" value="AA958_06065"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_06065"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1267"/>
    <dbReference type="OrthoDB" id="1828250at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="274" mass="27685" checksum="F943EF7DF8072772" modified="2015-07-22" version="1">MSTPSLTAPGTGRTRVAAGGGYRVTYPRVLRAEWSKLWSLRSTWYSLAAVAVLAAGIGLAIGASYTDGGGDGPQDPVEVSLLGLNFGLLILAVLGILTTAGEWSTGMVRATMSAVPRRLPVLWAKAVVFGTVSFVLTLATALVTFPLAQAFLAGTPIAAGLGDPGVGRALVTTAAGAALIAVLGVAVGALLRGVPASIGAFVAVLMVVPSVAPLLPYDWVEDAVAYTPLAAMEPLMAAHPAPDLPSIGAALVTMAVWAAAGLAGAALRLRRHDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N538</accession>
    <name>A0A0F7N538_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_10095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015860.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_10095"/>
    <dbReference type="EnsemblBacteria" id="AKH82518">
        <property type="protein sequence ID" value="AKH82518"/>
        <property type="gene ID" value="AA958_10095"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_10095"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2126"/>
    <dbReference type="OrthoDB" id="1439833at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="33"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="305" mass="32012" checksum="E48030B06C9E13B5" modified="2015-07-22" version="1">MSPRIPGFDYRRVPVADGVALSAAVGGNPGGSAVVLLHGFPQTHLMWRHVASRLAADHTVICPDLRGYGASDKPAEAAGGPGGGTYAKRTMAEDVVALTRALGHERFALAGHDRGALVAFRAGLDHPDAVTHLACLDVLPTLDMWDVMHGVSAAVGFHLYLMAQPPGLPEEMIAAAPDAFFGHFLDVWSGGGDTFPADVRAAYLAASREAVPSIVADYRASAGVDVEHDTADRDAGNLLRMPVAVLQQDWGAALGFDAAARWRAWAPDLRHATVSCGHFMAEEAPDEVAAALRDLLARTSAATTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N596</accession>
    <name>A0A0F7N596_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hydroxymethylglutaryl-CoA lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_10340</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HMG-CoA lyase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015901.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_10340"/>
    <dbReference type="EnsemblBacteria" id="AKH82559">
        <property type="protein sequence ID" value="AKH82559"/>
        <property type="gene ID" value="AA958_10340"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_10340"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2179"/>
    <dbReference type="OrthoDB" id="1111394at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016833">
        <property type="term" value="F:oxo-acid-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043594">
        <property type="entry name" value="HMGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42738">
        <property type="entry name" value="PTHR42738"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="3">
        <location>
            <begin position="19"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH82559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="316" mass="33145" checksum="06F5B66C9805A6E3" modified="2015-07-22" version="1">MTPQPLPMRVPAAGLPARVRIHEVGPRDGLQNEKATVPTDVKAAFVHRLAAAGLTTVEATSFVHPKWVPQLADAEDLYPRLADLTATGAVDLPVLVPNIRGLERATALGARRVAVFASATETFARRNLNRTVDESLAMFAPVVAEAKNDGLHVRGYLSMCFGDPWEGPVPLPQVVRTARALADMGCDELSLGDTVGVATPGHVAALLGALAQDGIPVERLGVHFHDTYGQALANTLAALQHGVTTVDASAGGLGGCPFARSATGNLATEDLVWMLQGLGVETGVDLDALVATSVWMADRLGRPSPSRTVTALSHKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5B4</accession>
    <name>A0A0F7N5B4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GCN5 family acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_06895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015338.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_06895"/>
    <dbReference type="EnsemblBacteria" id="AKH81987">
        <property type="protein sequence ID" value="AKH81987"/>
        <property type="gene ID" value="AA958_06895"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_06895"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1441"/>
    <dbReference type="OrthoDB" id="942650at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="291" mass="30595" checksum="6D8CF45237E7A7D8" modified="2015-07-22" version="1">MILRQVRDSKDDAEAVRATAYAAFAASHAAKGDPPEEADESDAILLRSVVRHLARTDPSGCWLALDDTGKTLGAALSTRREGTWGLSLLVVTPEAQGKGIGKALLARTLAYGRGCLRGLICGSRHPHAARAYRAAGFTLHPAMRLRGTVDHAGLEPPTGAVVEGGPGQRDLMDSVDRRLRGGAHGPDHTELLRHYQCIVSDDLAGSGYAYLRDGEVGMLAATSRRIAARLLTAALLSLAPGAAARVAHLTADQEWAVDVGLAAGLELTTAGYVCVRGMRPPAPYIPSGMLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5M4</accession>
    <name>A0A0F7N5M4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_11195</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016041.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_11195"/>
    <dbReference type="EnsemblBacteria" id="AKH82703">
        <property type="protein sequence ID" value="AKH82703"/>
        <property type="gene ID" value="AA958_11195"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_11195"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2359"/>
    <dbReference type="OrthoDB" id="1510342at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="107"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="138"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="168"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="215"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="103"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH82703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="307" mass="33320" checksum="B32E2D2DDCD55AFC" modified="2015-07-22" version="1">MTTAAAAETAPKPEPQKAEAEAPVKESLAARIGRYAGGGAVRAFLVIVAFLWLTPTVGLLISSFRDPADIATTGWWKVFGDPGQLTTETYDTLFGNEDVMGALPTTIWITVPSTLLVVVIGALAGYAFAWMEFPGRDWVFLAVVGLLVVPVQVALIPIASLYRDLNLFHTITGVVLFHTAFGLPFAIFLLRNFFAEIPRELLEAARIDGASELRLFFRVVMPLGGPAIAALSIFQFLWVWNDMLVALVFADPGKPPLTVAVQQQTRQFDSNIELIASGAFISMIIPLVVFFAFQRQFVSGVMAGAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5N6</accession>
    <name>A0A0F7N5N6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome c oxidase subunit 1</fullName>
            <ecNumber evidence="9">7.1.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AA958_15215</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 9">Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 9">
            <text>4 Fe(II)-[cytochrome c] + 8 H(+)(in) + O2 = 4 Fe(III)-[cytochrome c] + 4 H(+)(out) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11436"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="7.1.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the heme-copper respiratory oxidase family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.9" evidence="9"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_15215"/>
    <dbReference type="EnsemblBacteria" id="AKH83341">
        <property type="protein sequence ID" value="AKH83341"/>
        <property type="gene ID" value="AA958_15215"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_15215"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3205"/>
    <dbReference type="OrthoDB" id="316745at2"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070469">
        <property type="term" value="C:respirasome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015990">
        <property type="term" value="P:electron transport coupled proton transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006119">
        <property type="term" value="P:oxidative phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.210.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023616">
        <property type="entry name" value="Cyt_c_oxase-like_su1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036927">
        <property type="entry name" value="Cyt_c_oxase-like_su1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000883">
        <property type="entry name" value="Cyt_C_Oxase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023615">
        <property type="entry name" value="Cyt_c_Oxase_su1_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014241">
        <property type="entry name" value="Cyt_c_oxidase_su1_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10422">
        <property type="entry name" value="PTHR10422"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00115">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01165">
        <property type="entry name" value="CYCOXIDASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81442">
        <property type="entry name" value="SSF81442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02891">
        <property type="entry name" value="CtaD_CoxA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50855">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00077">
        <property type="entry name" value="COX1_CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0186">Copper</keyword>
    <keyword evidence="8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="175"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="213"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="259"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="295"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="322"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="365"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="405"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="438"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="477"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="COX1" evidence="11">
        <location>
            <begin position="36"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00025218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AKH83341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="573" mass="63305" checksum="7971EEC565971676" modified="2015-07-22" version="1">MSAPEGSHTGTATAETGYENELPVRRRKPGNVVVKWITSTDHKTIGTLYLSTSFAFFLAGGVMALAIRAELARPGTQILSHEQFNQAFTMHGTVMLLMFATPLFAGFANWIMPLQIGAPDVAFPRLNMLAYWLYLFGSLIVISAFLTPQGAADFGWFAYSPLSDAVRTPTVGADLWIMGLALSGFGTILGSVNFITTIVCMRAPGMTMFRMPIFTWNILLTSVLVLLAFPVLAAALLALEADRQFGAHVFDAANGGAILWQHLFWFFGHPEVYIIALPFFGIVSEILPVFSRKPIFGYMGLVVATITIAGLSITVWAHHMFVTGAVLLPFFAFMSFLIAVPTGVKFFNWIGTMWTGSLSFETPMLWSIGFLVTFLFGGLTGVLLASPPLDFHVSDSYFVVAHFHYTVFGTVVFAMFAGFSFWWPKFTGKLLDERLGKIQFWTLFIGFHTTFLVQHWLGAEGMPRRYADYLAADGFTTLNTVSSIGSFLLGLSVLPFLYNVWKTAKYGKKTEVDDPWGFGRSLEWATSCPPPRHNFVTLPRIRSESPAFDLRHSDLAALGKAASGPHARSGRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5N7</accession>
    <name>A0A0F7N5N7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoadenosine phosphosulfate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_18710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="STRING" id="444103.AA958_18710"/>
    <dbReference type="EnsemblBacteria" id="AKH83895">
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        <property type="gene ID" value="AA958_18710"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_18710"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3923"/>
    <dbReference type="OrthoDB" id="674332at2"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="266" mass="29724" checksum="E6A7DFD9C3023C56" modified="2015-07-22" version="1">MKVVSYGGGVQSTALLVLAARGEIDFRTFLFANVGDDSEHPATLAYVREIAIPYAARAGLDVHELKRRRRDGATETLMQRLNRPGTRSIPIPVRMVNGAPGRRNCTADFKIKVVGRWLREHGATAEEPAAVGIGISVDEIHRANRRRREAHEVIEYPLLDLRLRRDDCERIIAEAGLPVPPKSSCFFCPFRTVGAWRHQRRHEPELFAQSVRLEETINRQRAALGRDAVYLTRYGIPLTQAIPDESPGEGDADEDEGACDSGWCMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5Z5</accession>
    <name>A0A0F7N5Z5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AA958_15955</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNQ-509</strain>
        </source>
    </reference>
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    <dbReference type="EnsemblBacteria" id="AKH83456">
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        <property type="gene ID" value="AA958_15955"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_15955"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3361"/>
    <dbReference type="OrthoDB" id="643917at2"/>
    <dbReference type="Proteomes" id="UP000034283">
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    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042883">
        <property type="term" value="P:cysteine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034775">
        <property type="term" value="P:glutathione transmembrane transport"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014223">
        <property type="entry name" value="ABC_CydC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014216">
        <property type="entry name" value="ABC_transptr_CydD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02868">
        <property type="entry name" value="CydC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02857">
        <property type="entry name" value="CydD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="275"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="309"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="676"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="711"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="791"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="818"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="895"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="931"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="20"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="413"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="677"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="992"/>
            <end position="1256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="107"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="354"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="635"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1056"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1258"/>
            <end position="1297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1057"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="447"/>
            <end position="454"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="1026"/>
            <end position="1033"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AKH83456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="1297" mass="134632" checksum="08FCF7B3EA15CB04" modified="2015-07-22" version="1">MKPVDPRLARYARATRLFLLATVALGAAGAGLVIAQAVLMAEIVVGAFEDGLPAAALRTPLLLLAAVAAGRAVVSWLTELAAHRSSAAVKSELRMRLLTEAVRIGGSRAPARPGAAGPEKQDTDGPEKQGTDRPETQAADGAAGGELRTGELAALATRGIDALDAYFARYLPQLGLAVVVPAAVLARIVTDDWVSAAIIAGTLPLIPVFMTLIGWATQAATDRQWRTLSRLSAHFLDVVSGLPTLKVFGRAKAQADNIRTITADYRRATMRTLRIAFLSSFALELLATISVALVAVTIGMRLVHGELDLYTGLVVLILAPEAYLPLRQVGTHYHAAAEGLAAADRVFAILERGEPREAEARPTAPATGTVPVPAPADSTTAAATATAAPAPHARPRVGAPTDNACPDARHADLVLDGLVVRHEGRTEDSLPRTDLTLRPGETVALTGPSGGGKSTLLAALLGLVPPASGRVLIGGRDLAGLDLPSWHAQVAWVPQRPALFAGTIADNVRLPRPDATDAEVVRALRDAAAGDLDPAAVLGEGGAGLSAGQRQRVALARAFLADRPVVLLDEPTAALDGDTEAAVTAAIARLARGRTVLLVAHRPALLGVADRVVRLGEGRPPAAAGTHAVRAGAEVPAARSVPERAGEGTYGSGSYEPEEAPRGGSALRTTTARGRLALAALLGALALASAVGLMGVSGWLISRASEQPPVLYLMVAVTATRAFGIGRAVFRYAERLVSHDAVLRILADLRVAVYTRLERLAPAGLAPHRRGDLLTRLVADTDTLQDRYLRWLLPVSAAALVGAGSVGMAAVLLPEAGAVLAAGLLAAGVGVPLLAVATARRTETRLAPARAALATEVVDVLTGTAELAVAGALPRRLAALRDADRRLTRIAARSAAALALGAGLSALICGLTVVGAAAAGAQAVYEGRLPGVWLGVVVLGTLAAFEAVNGMPLALQQRARVRRSAARVDEILEAPPPAAEGTGRPPSDPFPVTLTGVVARHPGQAGLALDGVDLALTRGRRVAVVGASGSGKTTLAHVLLRFLDPVAGAYRLGEEGEGTALDPERRSPEHRSPASALLSHESTADALVCDPDAVRRLVGLCAQDAHLFDSTLRENLRLACIDATDDDLREALAAARLLDWVETLPLGLGTPVGEHGARLSGGQRQRLALARALLADFPVLVLDEPAEHLDLPTADALTADLLAATEGRTTVLITHRLTGLEAVDEIVVLERGRVVQRGTYAELAEANGPFRRTLLRERAHPSPYPYETADGRGAPGEPHVTDNPDFPHREPLITLGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N620</accession>
    <name>A0A0F7N620_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_12250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
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        <location>
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            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="205" mass="21536" checksum="61D307C5446F5AF1" modified="2015-07-22" version="1">MEENKGLKVTPVNAAAMDPAALPGLVPSPPDEKEKEQDEAETTDEKTESEDSAAAADTEDAADDDSDEDEADKAGSAGKDAEGDADDADEDKATASGDSEAGASDDPGSDGDGPVFEAADRRGSVTIDSTGVRFQLDDTEAEFTWPEIGAVEYKTSRFGRRLVLSVHDDRGICPAEVEAPDKATLKTWAADLESALDAYFEETSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N622</accession>
    <name>A0A0F7N622_9ACTN</name>
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        <submittedName>
            <fullName evidence="3">Inositol-3-phosphate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_16115</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
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        <text evidence="1">Belongs to the myo-inositol 1-phosphate synthase family.</text>
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_16115"/>
    <dbReference type="EnsemblBacteria" id="AKH83481">
        <property type="protein sequence ID" value="AKH83481"/>
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    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_16115"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3396"/>
    <dbReference type="OrthoDB" id="669352at2"/>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Myo-inos-1-P_Synthase"/>
    </dbReference>
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        <property type="entry name" value="Myo-inos-1-P_Synthase_actino"/>
    </dbReference>
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        <property type="entry name" value="Myo-inos-1-P_Synthase_GAPDH"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015578">
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    </dbReference>
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    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03450">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="191"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH83481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="360" mass="39471" checksum="9437CF6117586B62" modified="2015-07-22" version="1">MGSVRVAIVGVGNCAASLVQGVEFYKDAAPGSRVPGLMHVQFGDYHIRDVEFVAAFDVDSKKVGLDLADAIGASENNTIKICDVPNSGVTVQRGHTLDGLGRYYRETIEESAEEPVDVVQVLRDRQVDVLVCYLPVGSEDAAKFYAQCAIDAGVGFVNALPVFIAGTKEWADKFTAAGVPIVGDDIKSQVGATITHRVMAKLFEDRGVILDRTMQLNVGGNMDFKNMLERDRLESKKISKTQAVTSQIPDRDLGEHNVHIGPSDYVAWLDDRKWAYVRLEGRAFGEVPLNLEYKLEVWDSPNSAGIIIDALRAAKIAKDRGIGGPVLSASSYFMKSPPVQYFDDEARENVEKFIRGEVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N628</accession>
    <name>A0A0F7N628_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_19715</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_19715"/>
    <dbReference type="EnsemblBacteria" id="AKH84035">
        <property type="protein sequence ID" value="AKH84035"/>
        <property type="gene ID" value="AA958_19715"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_19715"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4155"/>
    <dbReference type="OrthoDB" id="1512052at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH84035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="325" mass="33095" checksum="23F94B1DFB0C9B8B" modified="2015-07-22" version="1">MTAGNHGAGTPPEDDDPFAHLYRPEGGAAPVPGPGEGTAPAPGVPRTSYTQVRAVGERTYGGQQAAHQVPPQQAYPYGQSSPSPHYAAPETYGGPPPQPPSSPPGDPGDGPRRGRGGGRNGLMLGAVAVVATVVIAIVAAVLFSGDGEDSDVGGGDSESVAPSPGGKGDDGPKNGDDKPEKDPTAPPSEDGAKLALAGGAVVGSDANVSEDGPYVHGLENEGASATWKPEVGEAGEYTLFVDYSVPGKDAELTLTINGEAESRPLNLENFAKAKKDDWLAGWTRTYSWISLDEGANEITLSCESGNKECQSAIGKVELKKGQVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N642</accession>
    <name>A0A0F7N642_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Endoribonuclease L-PSP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_08690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015645.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_08690"/>
    <dbReference type="EnsemblBacteria" id="AKH82297">
        <property type="protein sequence ID" value="AKH82297"/>
        <property type="gene ID" value="AA958_08690"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_08690"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="SSF55298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519175" evidence="1">
        <location>
            <begin position="29"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="216" mass="22367" checksum="39ABCD9415C3CAD5" modified="2015-07-22" version="1">MNAPKRRAVMLTAAGAGGALLTSATAFAAARGWRPGPRQVKVMLPSGQSNPAIATGVATGESVALYASSGLGPDALNPAAPAGTPEHWTDPSMTEGAEGVTVTEAQALVVLRKISDNLAVAGLAPADVITMKCYLMKPPRAELADYAGWNRAYRQFYANVDLASGETVPAPMGTSAPKPPILVNRARPARATMEVASLAVPGWLVEVEVTAAYRMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6K4</accession>
    <name>A0A0F7N6K4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_17520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017010.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_17520"/>
    <dbReference type="EnsemblBacteria" id="AKH83706">
        <property type="protein sequence ID" value="AKH83706"/>
        <property type="gene ID" value="AA958_17520"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_17520"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3687"/>
    <dbReference type="OrthoDB" id="447734at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027020">
        <property type="entry name" value="YnjB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029172">
        <property type="entry name" value="UCP029172_ABC_sbc_YnjB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519833" evidence="1">
        <location>
            <begin position="22"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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    </evidence>
    <evidence type="ECO:0000313" key="3">
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    </evidence>
    <sequence length="421" mass="45642" checksum="515DE7EC106171F7" modified="2015-07-22" version="1">MRIRTRRPALRRSRSGTGAAAWTGAAAMLLAACSGGGDQEALPKNWSELRAAARGQTVNLFMYGGDQGANAYVDDEVVPAAEKLGIGVKRVPVADTQDALQKVLGDIRAGKDSGGAVDLVWVNGENFRTGKEAGLWLCGYTGLMPNQKYVDDSDPTLTHDFGTPVDDCETPWSRAQFAFVYDSARIPDPPRTTAGLIEWAEKNPGRFTYPAPPDFTGSAFVRQMLYTTAQNGAAVPQTYSESAYEKVTPALWEQLAGLRPHLWRDGTTYPKDAAAQGDLFANGEVDMTMTYNPAEVPGLVARGHYPKSTRVFVPEDGTLGNTSYLAVPENAAHREAALVLSDLMLSPAQQHAKAQPGGWGAYTVLDHERLPERWRKKFAALDTPATTLPIDELSRNARPELSGDWVAPLDKGWKQHVPTGS</sequence>
</entry>
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                <person name="Kaysser L."/>
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    <evidence type="ECO:0000259" key="1">
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    </evidence>
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            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="64" mass="6839" checksum="06D0D1FC61142A32" modified="2015-07-22" version="1">MSSRSEWFKSSYSGQNGECVEIRRGATAISVRDSKDPGSGVLAVSAAAWADFVAAVRRGEFPQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N706</accession>
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                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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    <dbReference type="EnsemblBacteria" id="AKH84365">
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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</entry>
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                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </evidence>
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            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="388" mass="38175" checksum="58D31B8C4C387395" modified="2015-07-22" version="1">MPFPLYLLALVVFAMSTSEFMLAGLLPDIASDLGVSVGTAGTLTSAFAVGMVAGAPLVAALARNWPGQSTLLVFVLAFAAAHVVGAVTGSFAVLFATRILAALANAGFLAVALTTAAGLVPPDRKGRALAVLLSGTTVATVAGVPGGSLLGAAFGWRATFWAVAALCLPAALGILAGVPRRRARQDAVGGPALRSEIARLRSPRLILVMLLGALVNAATFGSFTFLAPLVTDTAGLATPWISVALVLFGAGSFAGVTFAGRLADVRPGAVVAVGGPLLLAGWPVLGLLAAYPVALLALVCVLGALSFAVGSTLITRVLYEAAGAPTMAGAYATAALNVGAVAGPLVAAGAIGAAGNRGPLWASGVLVLAALLVAAPFRGVVAGARNGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7F7</accession>
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        <lineage>
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                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH82782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="222" mass="24032" checksum="70C01201A0F2FB99" modified="2015-07-22" version="1">MTHEHPTYILNDSVTAPDREAWFALPAGFTTLPLDALTASSDSADASRMREVVGDLLAGVPDGVGRQRVIGQLAGAQRMMLALREEGVVHCSLGLHRDDDGDGRLLTSFFTFRWQEISRAPRHLTAARAVAAGHDRIEVLDLPCGPAALGEVARSVAPGLGIAVERLLQIHAYLPHPDGSRIAVLTLTTPAPQRRAHYRAMLHDVAAHVSFDDPLVHLRTNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7U7</accession>
    <name>A0A0F7N7U7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_12200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EnsemblBacteria" id="AKH82872">
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    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_12200"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2566"/>
    <dbReference type="OrthoDB" id="1681721at2"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519220" evidence="1">
        <location>
            <begin position="31"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="334" mass="35847" checksum="4347C2D599B377E8" modified="2015-07-22" version="1">MTGRPTRRTALLTALGAGAAATLPAAAAHAAGSRPTPPVAVTDQKSRRVLILDSRLPWDSPDAVRWAFSPEGDERYADLVPQASWTYVDEAKARRHKGRTYLLTSASFGFAAVVEVPTGRRYWAGALAGGTDSVNPHSVELLPDGNVAVAGSTGDTIRLYAASQGPATATYFEYRFDDAHGLQWDTRNGLLWAIGYDELIALRVGGTPAAPTLTRVDSAALPHPDGVRAGGHDLSLVASRPGRLWLTTNYGVYQYDIARREFSQDFAGAAQISRRSVKAVSDVPGSGRVATTVPEPGLGKTWWTTTVSAHNPEGAFKLPDSGIYKARWWLPEPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7W3</accession>
    <name>A0A0F7N7W3_9ACTN</name>
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        </submittedName>
    </protein>
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    </gene>
    <organism evidence="2 3">
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_16165"/>
    <dbReference type="EnsemblBacteria" id="AKH83489">
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        <property type="gene ID" value="AA958_16165"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_16165"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3406"/>
    <dbReference type="OrthoDB" id="1526822at2"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0008080">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="205" mass="22698" checksum="8819898FF594F601" modified="2015-07-22" version="1">MGRRLVPLTLDNLPDFPRRCRSCVFWELDPVSGEAAVKSGHPEREKEAWISSVLLEWGSCGRVLYVDDVPAGFVMYAPPAYVPRSLAFPTSPVSADAVQLMTAWLNPGYQGQGLGRTLVQTVAKDLLRRGVKAVEAFGDAAWKEPACVLPADHLVAVGFKTVRPHHRHPRMRLELRSAISWKEDVELALDKLLGGARKDPVLRPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-10-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N866</accession>
    <name>A0A0F7N866_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_16945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH83619">
        <property type="protein sequence ID" value="AKH83619"/>
        <property type="gene ID" value="AA958_16945"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_16945"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3565"/>
    <dbReference type="OrthoDB" id="1744037at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
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        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
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    </dbReference>
    <dbReference type="SMART" id="SM00347">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="16"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="160" mass="17795" checksum="2B35A862C64F11AC" modified="2015-07-22" version="1">METADETRFDRGDETPERLKRQLSRLVGMTAVQTRRVAGDALRAVGARKDHFVVLATLAEAGPASQAALSGRTRIYKSDLVSVLNDLADGGWVRRTPDPADKRRNVITITEDGERRLDELDRVLDGVNEHIMAPLGRDERTQLFALLGRVNAHLDDVPDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N888</accession>
    <name>A0A0F7N888_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_17260</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_17260"/>
    <dbReference type="EnsemblBacteria" id="AKH83668">
        <property type="protein sequence ID" value="AKH83668"/>
        <property type="gene ID" value="AA958_17260"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_17260"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3629"/>
    <dbReference type="OrthoDB" id="2047542at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
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        <property type="entry name" value="BetI_C"/>
    </dbReference>
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        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13977">
        <property type="entry name" value="TetR_C_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="6"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="2">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH83668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="190" mass="20317" checksum="C0155344CE9E7C99" modified="2015-07-22" version="1">MAVKGAQTRARLVEAARTLVEARGYHGTGLNDVIAAGSAPRGSLYHHFPGGKDQLTAEALTVSGREITIVFADLADSAPDTRSLMESALSLLADRMEEAAYAKGCPVATVALEVSARNDALRQVCAEIYDRWQRVLADRLIADGRSPADAEDLACSLLALTEGALILSRTRRSRAPMEQARRTARALLDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-12-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8B2</accession>
    <name>A0A0F7N8B2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AA958_24190</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018052.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH84800">
        <property type="protein sequence ID" value="AKH84800"/>
        <property type="gene ID" value="AA958_24190"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_24190"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5097"/>
    <dbReference type="OrthoDB" id="149255at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004869">
        <property type="entry name" value="MMPL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03176">
        <property type="entry name" value="MMPL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
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            <end position="199"/>
        </location>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="7">
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="7">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="414"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="570"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="617"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="637"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="679"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="713"/>
            <end position="738"/>
        </location>
    </feature>
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            <begin position="196"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
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            <begin position="339"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="763"/>
            <end position="785"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AKH84800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="785" mass="79292" checksum="ADED2D241967BC4A" modified="2015-07-22" version="1">MATFLYRLGRFAFRRRLPVALLWAAVLGAAFLGATSAGDPPDDSSSMPGIEAQHAYDLIDERFPGAAADGADARVVFVAPGGEKITGGTGRAAVGAFVADVTGAPQVAAVASPFDGQGVSDDGTTAYATVTYEVAEDDVSEAARAALDDAVEEARDAGLTVEAGGSAVGSEEAAGLGEVVGIAVAAVVLLVTFGSLAAAGLPLITAVVGIGVSMCAILALGSALGLSSTVGELAMMLGIAVGIDYSLFVVSRYREERAAGHEPREAAGRATGTAGSAVVFAGLTVVIALAGLSVVGVPMLTKMGLGAAGAVLVGVLVALTLVPALLGWWPNAVLARGARGPGTGGGSGAGRRGRWRLGGRGSAERTSPPGRTTAPGRMSAPDGTGSPYGAGPAGSAAPATPAVRWARFVLRRPVPVLLATVAGLGLLAVPAADLRLGMPGDEAKPASTTERRAYDALAAGFGPGFNGPLTVVVDARGAADPRAAVAGVAAALDATDGVVSVSPPRFDEPGETAVLSATPATAPTSERTRDLVHDIRGQRAATEAATGATYEVTGATALNIDVGQKLQDALIPYLATIIGLAFFLLLLVFRSVLVPLKAALGFLLSVLAALGAVVTVFQQGHLAGLFGIEQTGPIMSMMPIFLVGIVFGLAMDYQVFLVSRMREAYVHGEDARAAVVSGFGHSARVVAVAAVIMMAVFAGFMTGGEQVIRMIGFGLAVAVLFDAVVVRMAFVPAVLALLGKRAWWLPGWLDRLLPRVDVEGEALGRGAPGPRPVPDDEAGHGLTRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8H9</accession>
    <name>A0A0F7N8H9_9ACTN</name>
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        </submittedName>
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    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
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        <lineage>
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            <taxon>Actinobacteria</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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    </dbReference>
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH83813">
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        <property type="gene ID" value="AA958_18160"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_18160"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3818"/>
    <dbReference type="OrthoDB" id="1374150at2"/>
    <dbReference type="Proteomes" id="UP000034283">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH83813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="209" mass="22298" checksum="189AB3A03F8427F7" modified="2015-07-22" version="1">MPTTPPASDGIPPVWFTVPDGFHPLPIAATAEERADLAGEFVRELLPNGDDTLWASTAPYYAGMGELMGSCGLAYSALGLFARDEGGIAHCAFHVGAWESGHPSVEAAANGVREVLVRDPANDVRWVDLPCGPAVSCMTLREFTLPAELAADSQESKLRAGQIQVHVPFPTGPYISVFTVDTVAMDYWGEFCDMTAAVLQTVSFSPPQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8I5</accession>
    <name>A0A0F7N8I5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ArsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_24455</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="3"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH84840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="129" mass="14765" checksum="1551C4A04B75AB19" modified="2015-07-22" version="1">MTSVPEPDERLSLVFSALADPTRRDIVARLTAGDATVNELAEPYDVSVQAVSKHIRVLEEAGLVSRSRDAQRRPCHLQAEVFDLMTKWIERYRRAAEDRYRRLDAVLERMDAQEGPPVEKTRTEREEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8V8</accession>
    <name>A0A0F7N8V8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PfkB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_14090</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH83177">
        <property type="protein sequence ID" value="AKH83177"/>
        <property type="gene ID" value="AA958_14090"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_14090"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2965"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
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        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF53613"/>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="3">
        <location>
            <begin position="38"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH83177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="309" mass="33403" checksum="FE3243137C7ACBC4" modified="2015-07-22" version="1">MMPRFVIVGMTRLAMTAPVEEFPLQYSAYRSASWMRCTVVGGAYNVAGALRKLGSEAHVCTLVGTDEAGAVIREAMERRGLKGRGVVDVAETAKTMILTDPSGRVARNAWAVGGSGDYPMERFIEQGVDADLAVITNRPFGEPFLRPAKELLGLPVAVDLHVSADLDDESHRPWLEVADVLFCSHERLPGTCAEWIGEVFRRYPGCRIAAVGRGEDGCVMGLQDGRLVEIGAVTPRPVRDTDGAGDALFASFLHGWLTSGKPVEALESAVLFAGWKVGAGSAAEGFLTDRELAALRRVYPLRTRVGTWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N908</accession>
    <name>A0A0F7N908_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_18850</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017211.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_18850"/>
    <dbReference type="EnsemblBacteria" id="AKH83914">
        <property type="protein sequence ID" value="AKH83914"/>
        <property type="gene ID" value="AA958_18850"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_18850"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3957"/>
    <dbReference type="OrthoDB" id="246216at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032689">
        <property type="entry name" value="TraG-D_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12696">
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="598" mass="63301" checksum="3D5DFD3E435B33C5" modified="2015-07-22" version="1">MPPSSFPNGSTDGYDLVLRLILGVVAVVVPLSHLAWLSGNITAHLTGNDWAPYQPTDALLHPEQVWPDVGETSLLIGARIAPATLLLAVGAAGIALWIRHRNRRGAGKKKAPVLAQARDIEPLMAKAITAKARSLRPSLKTSKHIDAHDTGVLLGNLQGTRREVRMGYEDVAVAIMAPRSGKTTALAIPAILAAPGPVMLTSNKAAGDAYTATLNARAAVGRVWSMDPQQIAHAERAMWWNPLADATTLEGAGRLAGHFLAASVDASQQGDFWSKAGSNILAQLFLAAALDERPVTDVMQWLAFPADRTPLDILRDHGHTAVAAQLKGTVEGPPETRDGIYETARQYAAALLDTKIAAWVTPQKDVPEFEPAEFVTATDSLYLLSKDGGGGASALIAACADSVMRAATTQAERAGGRLDPPLLAILDEAANVCKISDLPDLYSHLGSRGIIPITILQSYRQGQKVWGDAGMDALWSAATIKIIGSGIDDPDFADKLSRLIGDHDVETTSTSHSESGRSMSVSMRQERILPADAIRALPKGMAICFATGMRAAMLTLRPWYLEPGAADLSAASDRASKAITTRAVAKHAPTQADFGPAA</sequence>
</entry>
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="151" mass="15930" checksum="144AECFE42E47E32" modified="2015-07-22" version="1">MTFVGRVLRVAAAVAGAAVVLGGVLWLADDVLRGLPADSAQLRPAAGRSAGASAYAPAEYAEHVTGVETEWEGDTAVRTVISTDLADDAAGRRIAVGIKVAHMQQLLADCVEKLPVVVVNDREGDEIRHRDVLSFSRERGDDCPARAPRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N984</accession>
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        </submittedName>
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    <gene>
        <name evidence="2" type="ORF">AA958_14955</name>
    </gene>
    <organism evidence="2 3">
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        <lineage>
            <taxon>Bacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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    </dbReference>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519196" evidence="1">
        <location>
            <begin position="29"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="150" mass="16287" checksum="28289D3DA60810D7" modified="2015-07-22" version="1">MRPTAKKGLVAAGVTAAALLATVAPAEAAPADKPQVLASFTQTSATSYNSWAAAEANRGAWSAYAFNWSTDYCSSSPDNPFGFPFQKACQRHDFGYRNYKEIGGFDANKSRLDSAFYEDLKRVCNRYSGATKTSCNSTAWVYYQAVRAFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9K6</accession>
    <name>A0A0F7N9K6_9ACTN</name>
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        <submittedName>
            <fullName evidence="5">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_20725</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
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        <lineage>
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        </lineage>
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    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH84213">
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        <property type="gene ID" value="AA958_20725"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_20725"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4371"/>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
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        <location>
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            <end position="79"/>
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    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="37"/>
            <end position="154"/>
        </location>
    </feature>
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        <location>
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    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AKH84213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="402" mass="42987" checksum="D8EDECF81924757E" modified="2015-07-22" version="1">MSHSRPGAEPPVKPGGDKPLPPPRPPLSGTTWREIVHLLVNLPMAIFAFAYVSIWLYAGALLSITVIGLPLLAAGLAGARGIGAWERARARALLGVHVESPTPIRRSTYGGFLPWLWATLKDPVGWRTTLYSVMRLPWGVLTFALMSVSLFVLWPLLPWLARGLSDVDRAMVRGLLSPSDPLERRIKELEENRGVVVDTAAADLRRIERDLHDGAQARLVALAMGLGLAKEKLLEDPEAAAEMVGEAHGEVKLALEELRDLARGIHPAILTDRGLGPALSAVAARCTVPVSVTVDLKDRPAQAIEGIAYYTVSELLQNISKHSGAKTASADVWRAEGRIMVQVTDDGKGGARLDGGTGLSGLAERLGSVDGLLVVESPGGGPTVVTAELPWRNRESQTPAHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9S3</accession>
    <name>A0A0F7N9S3_9ACTN</name>
    <protein>
        <submittedName>
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        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="4 5">
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        <lineage>
            <taxon>Bacteria</taxon>
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    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_20995"/>
    <dbReference type="EnsemblBacteria" id="AKH84258">
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        <property type="gene ID" value="AA958_20995"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_20995"/>
    <dbReference type="OrthoDB" id="1437290at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
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        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039536">
        <property type="entry name" value="TetR_C_Proteobacteria"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14246">
        <property type="entry name" value="TetR_C_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="7"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH84258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="228" mass="24319" checksum="B7B9FC8C94846249" modified="2015-07-22" version="1">MPTSPSRPAPERIVDAAERLIRTAGFVHATTKEIAREAGCSEALLYKHFVNKEDIFLRVLIERLPRLTTLFTELTDDDQDAEDTEDADGPGARGVEERLTAVARKAADFYEEMLPMVGALLAEPGLLTRFAEGLAAVGRKGPYEAGDALTDYLVRERERGRIRADADPRAAAGMLIGACFQRAFFVAFGGPAAVQPADDFAAALSRTLWAALAPPSAAAAPPAAPPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9T3</accession>
    <name>A0A0F7N9T3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">50S ribosomal protein L1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">rplA</name>
        <name evidence="11" type="ORF">AA958_21030</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9 10">Belongs to the universal ribosomal protein uL1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017546.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_21030"/>
    <dbReference type="EnsemblBacteria" id="AKH84263">
        <property type="protein sequence ID" value="AKH84263"/>
        <property type="gene ID" value="AA958_21030"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_21030"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4429"/>
    <dbReference type="OrthoDB" id="1671455at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00403">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01318_B">
        <property type="entry name" value="Ribosomal_L1_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005878">
        <property type="entry name" value="Ribosom_L1_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002143">
        <property type="entry name" value="Ribosomal_L1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_L1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_L1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_L1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023673">
        <property type="entry name" value="Ribosomal_L1_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002155">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="SSF56808"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01169">
        <property type="entry name" value="rplA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01199">
        <property type="entry name" value="RIBOSOMAL_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0678">Repressor</keyword>
    <keyword evidence="8 9 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7 9 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="5 9" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="3 9" id="KW-0820">tRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AKH84263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="238" mass="25573" checksum="A241DCA4258999F0" modified="2015-07-22" version="1">MKRSKALRSGDAKVDRTRQYAPLEAVRLAKETSTTKFDGTVEVAMRLGIDPRKADQMVRGTVNLPHGTGKTARVLVFATGDRAAAAEAAGADIVGADELIEEVQKGRLDFDAVVATPDLMGKVGRLGRFLGPRGLMPNPKTGTVTPDVAKAVTEIKGGKIEFRTDKHSNLHFIIGKTSFDEQKLVENYGAALEEVLRLKPSAAKGRYIKKATITTTMGPGIPVDPARVRNLLSEEPAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NA10</accession>
    <name>A0A0F7NA10_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_21340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017583.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_21340"/>
    <dbReference type="EnsemblBacteria" id="AKH84319">
        <property type="protein sequence ID" value="AKH84319"/>
        <property type="gene ID" value="AA958_21340"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_21340"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4493"/>
    <dbReference type="OrthoDB" id="1861956at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH84319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="289" mass="29544" checksum="3EC00933F221B578" modified="2015-07-22" version="1">MSFGQGGGYGGPGGQGQGSGFGPPGSGGPAPDWSALADSAAAERRRKRRLWTIVGGALATVVIAGAVAAAVVTTSGGDDDPSSSASEDRISGAGSESGKGDPSFSSVAPPPDPKEFIASADKDTAPLTVDSFFPNAEITVSGHTYERRATHHTRDCASGASSKLGKILTANGCDRLLRATYTREGTAVTVGVAAFADEGPAARTAEQAKGNLESLPGQGVPEFCRATACRLTSNTLGRYAYFTIAGYADGKAVTADDAPTSEAVRDTGAYVYRRIMDRGREQALQSTEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NA41</accession>
    <name>A0A0F7NA41_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chitinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_24895</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 18 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018157.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_24895"/>
    <dbReference type="EnsemblBacteria" id="AKH84906">
        <property type="protein sequence ID" value="AKH84906"/>
        <property type="gene ID" value="AA958_24895"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_24895"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5248"/>
    <dbReference type="OrthoDB" id="1081028at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="SSF54556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519423" evidence="5">
        <location>
            <begin position="40"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="6">
        <location>
            <begin position="50"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH84906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="417" mass="44523" checksum="0181FACE2FC6ADFF" modified="2015-07-22" version="1">MRSPHVRTRTRVIGILLTLALSIPLTVLATLAPSSSAGAATTPAGPRAAGVKMGYFTEWGVYDRNYHVKNMDTSGTAEKINTINYAFGNVQGGRCTMGDSFAATEKSYTADQSVDGVADTWDQPLRGNFNQLLKLKKKHPHIKILWSFGGWTWSGGFTQAMENPAAFAQSCYDLVNDPRWQGLFDGIDLDWEYPNACGLSCDSSGPAVMKDMMQAFRAKFGDQLVTAAVTADASEGGKIEAADYAGAAQYVDWYNVMTYDFFGAWDAQGPTAPHSPLTSYDGVPKQGFDSTAAIEKFRAAGVPANKLLLGIGFYGRGWTGVTQAEPGGTATGPAPGRYEQGIDDYKELKGKCPATGTVAGTAYAHCGNQWWSYDTPQTIGGKMSYAKEQGLGGAFIWELSGDTANGELMSAVNSGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NA59</accession>
    <name>A0A0F7NA59_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_16820</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016901.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH83597">
        <property type="protein sequence ID" value="AKH83597"/>
        <property type="gene ID" value="AA958_16820"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_16820"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3539"/>
    <dbReference type="OrthoDB" id="1725987at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519237" evidence="2">
        <location>
            <begin position="29"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH83597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="213" mass="21519" checksum="0008CE77B1934C95" modified="2015-07-22" version="1">MRSKVLLRSVLVAVAALAAAVVGPGAQAAPAPEARGAAAVEASAHDHAGHAAEGKPGEGHGITAKEFEALAAEGPQGRDFGANAWPVPTDRSYYLTSSCNAYAGAIAQGAAAWANLDRTSGSGTPVECRNSYITDCGGGGNIVGCNWGAGQRIALFMGGVNDDALLAAHEFGHDWYGHSTYQCAGWSSPAHVMAPSICNFGGNGAKSGPVRID</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAH8</accession>
    <name>A0A0F7NAH8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_17525</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_17525"/>
    <dbReference type="EnsemblBacteria" id="AKH83707">
        <property type="protein sequence ID" value="AKH83707"/>
        <property type="gene ID" value="AA958_17525"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_17525"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3688"/>
    <dbReference type="OrthoDB" id="1488093at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="68"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="106"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="208"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="69"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH83707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="297" mass="30310" checksum="5DA961669E87F380" modified="2015-07-22" version="1">MEAARADGLMTTHRARGLLLVLPALTVVALACCGLALAVRGSLADGLGAGWSPAAYAGLLDDPVLVGSLLLSLKIAAAGTAGSAVLALAVVGAVSTARRSRGVVEAVARATLAVPHALAAAAFALLLAGSGLLSRLARAAGWTDEPADFPALVAGEGQIAIVLSYVWKEAPFIVLMLLAAHTPAVRDLETAVRTLGAGRWQRLRHVTWPLLAAALLEACLLVFAFTFAAYEIPALLGATAPRALPVEAVELYRSVALEDRPRALALAVVIGAVVALAALAAAVISRRLLRARVGAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAN8</accession>
    <name>A0A0F7NAN8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Polyphosphate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_22795</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the polyphosphate kinase 2 (PPK2) family. Class I subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017815.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_22795"/>
    <dbReference type="EnsemblBacteria" id="AKH84558">
        <property type="protein sequence ID" value="AKH84558"/>
        <property type="gene ID" value="AA958_22795"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_22795"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4799"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008976">
        <property type="term" value="F:polyphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016898">
        <property type="entry name" value="Polyphosphate_phosphotransfera"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022488">
        <property type="entry name" value="PPK2-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022486">
        <property type="entry name" value="PPK2_PA0141"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03976">
        <property type="entry name" value="PPK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028756">
        <property type="entry name" value="PPK2_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03707">
        <property type="entry name" value="PPK2_P_aer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PPK2" evidence="5">
        <location>
            <begin position="3"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH84558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="258" mass="30184" checksum="64AE1A2BFF061C1E" modified="2015-07-22" version="1">MLRLQTELVTLQEWVRAEGERLVVIFEGRDAAGKGGAIKRVTALLNPRVVRIAALPVPTERERTQWYFQRYVARLPAAGEIVLFDRSWYNRAGVEHVMGFCTQKEYERFLHQCPGFERMLIEDGILLRKYWFSVSDAEQERRFRQRLSDPARRWKLSAMDLESITRWEAYSRAKDEMFVHTDLPEAPWFVVESDDKRAARINMIAHLLSTVPYREIRQPELRLPPRPPPSGYERPPKHLQTYVPDHAAALLGSSRRTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAX3</accession>
    <name>A0A0F7NAX3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AA958_26940</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018508.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_26940"/>
    <dbReference type="EnsemblBacteria" id="AKH85271">
        <property type="protein sequence ID" value="AKH85271"/>
        <property type="gene ID" value="AA958_26940"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_26940"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5668"/>
    <dbReference type="OrthoDB" id="692375at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="43"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="127"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="10">
        <location>
            <begin position="146"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="207"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AKH85271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="422" mass="45819" checksum="38CDE6CB7EE9FED2" modified="2015-07-22" version="1">MDDNRRSASDELPAGTPPKPTWDPREGAAPYWLRPTIRIRLTLIYGGMFLMAGMVLLAIIYLLAATALDSFATPFKLLESSGTVQVASGPCPEVSDAKTYDQFNGILEACIERRRQLALDSLLRKSLLALLGMTVLAFAFGYVVAGRVLSPLGRITRTARSVAGSDLHKRIELDGPDDELKELADTFDDMLDRLDRAFNAQQRFVANASHELRTPLAINRTLLEVQLSDPQASPELQQLGKTLLATNERSELLVEGLLLLARSENEIVDRKPVDLAEVASQALDQTRGEAQGKGVELRGVRKPAYVQGNGVLLERVGLNLVQNAVRYNVPEGGWVEVATEAQPGVAVLTVANTGPVVPAYEVDNLFEPFRRLRTERTGSDKGVGLGLSIVRSVIRAHGGTVTAQPREGGGLVIRVALPMQTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NB03</accession>
    <name>A0A0F7NB03_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">3-phosphoshikimate 1-carboxyvinyltransferase</fullName>
            <ecNumber evidence="7">2.5.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">5-enolpyruvylshikimate-3-phosphate synthase</fullName>
            <shortName evidence="7">EPSP synthase</shortName>
            <shortName evidence="7">EPSPS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">aroA</name>
        <name evidence="9" type="ORF">AA958_29475</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>3-phosphoshikimate + phosphoenolpyruvate = 5-O-(1-carboxyvinyl)-3-phosphoshikimate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21256"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57701"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="EC" id="2.5.1.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the EPSP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.19" evidence="7"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018914.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_29475"/>
    <dbReference type="EnsemblBacteria" id="AKH85685">
        <property type="protein sequence ID" value="AKH85685"/>
        <property type="gene ID" value="AA958_29475"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_29475"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6220"/>
    <dbReference type="OrthoDB" id="533829at2"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00089"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003866">
        <property type="term" value="F:3-phosphoshikimate 1-carboxyvinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01556">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00210">
        <property type="entry name" value="EPSP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001986">
        <property type="entry name" value="Enolpyruvate_Tfrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036968">
        <property type="entry name" value="Enolpyruvate_Tfrase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006264">
        <property type="entry name" value="EPSP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023193">
        <property type="entry name" value="EPSP_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00275">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000505">
        <property type="entry name" value="EPSPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="SSF55205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01356">
        <property type="entry name" value="aroA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00885">
        <property type="entry name" value="EPSP_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="EPSP_synthase" evidence="8">
        <location>
            <begin position="18"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Shikimate-3-phosphate binding" evidence="7">
        <location>
            <begin position="33"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoenolpyruvate" evidence="7">
        <location>
            <begin position="105"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Shikimate-3-phosphate binding" evidence="7">
        <location>
            <begin position="181"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="325"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="353"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>3-phosphoshikimate</name>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>3-phosphoshikimate</name>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="348"/>
        </location>
        <ligand>
            <name>3-phosphoshikimate</name>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="352"/>
        </location>
        <ligand>
            <name>3-phosphoshikimate</name>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="356"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="397"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="422"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH85685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="439" mass="46190" checksum="5D48F1165A4D4B92" modified="2015-07-22" version="1">MTGLPKNPILDLAEYEVTPVKSVDATVPVLGSKSYTNRHLAMAGLSSEPTTLHNALLSQDTLLLADALRAFGHVTVGIDEATNTVTVTPNGKQMTAPADEINMGNAGTPIRLLITMAGLAHGTTVLTGSERMQERPMGHLLDALDPLGVPALDLRGNGCPPISVEGPSLVGGPAYMHGTVSSQFTSSLLISAPYAREDVEVSLISELLSKPYVDMTVAAMAARGVQVERQGYRSFTVRAGQRYTGGDVTVEPDASGMSYFLAAAAILDGRVTIPGISGDSVQGDVDLVRALVSMGCKADVTGDSITFEGSDNLTGIEIDMVNMPDVVPTLAIVAAYAQGTTHITGIGNLRFKECDRIDAVATELTKMGVTVRTTKDTMTVEGGRPHGAVIDTYDDHRIAMAFAICGLRTPGVIIRDPGCVTKSFPTFWDRLAGLDQDAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NB35</accession>
    <name>A0A0F7NB35_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_29715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018943.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH85715">
        <property type="protein sequence ID" value="AKH85715"/>
        <property type="gene ID" value="AA958_29715"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_29715"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6273"/>
    <dbReference type="OrthoDB" id="1785082at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="281"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="392" mass="44055" checksum="69B469A58B3954D4" modified="2015-07-22" version="1">MPAHRTRHVALLVETSNAYARGVLVGVKKYVEAHPGWSMYLAEHSRHETDFSWLEDWQGHGVLARIESAETASFIRRLGLPTVDLSAARLVPELPGVETDDGTIARWALRHFEERGLRHFAFCGDERFGWSLKRGAWFAEHVRERGSVPREFRMKSTGMRAADRELLAEWLRGLPKPVGVFACYDIAGQEVLEACKTADLAVPDSVAVIGVDNDELIGNLTTPPLSSIEPDTTRTGYLAAELLDLMMQGRVLEPGLRLIEPTRLVTRQSSDILAVDDPLVAEALRFIRDRSDQNLAVTAVLRHIGLSRRALDHRFLRSLGRTVHGEIVRVRVAHVAELLSSTDWTLQQIAQRLRFSHSEYMSVVFKKHTGKSPGQYRRSVNGSVARQAFWSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NB37</accession>
    <name>A0A0F7NB37_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_23410</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017919.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_23410"/>
    <dbReference type="EnsemblBacteria" id="AKH84664">
        <property type="protein sequence ID" value="AKH84664"/>
        <property type="gene ID" value="AA958_23410"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_23410"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4935"/>
    <dbReference type="OrthoDB" id="955232at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="2">
        <location>
            <begin position="3"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH84664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="348" mass="35417" checksum="4E155BCA5D89E17A" modified="2015-07-22" version="1">MRVLLIGGTGFVGRYVADRLLADPAVQLTALGRGDDADVRFDLSSGSPGALTRFLDAVHPGVVVNCAGTTRGSARDLTRHNTVAVATLCEAMRRSSCSARLVHVGCASEYGPSPAGSSTAEDALPRPGGPYGVSKLAATELVLGSGLDAIVLRVFSPAGPGTPAGSPLGRLAEALRRAMQQGDGELKLGGLGAQRDFVDVRDVARAVHAASLSAAQGVVNIGGGRAVRLRDAAAALARIAGYSGQLHEFDTTLTGRIPQPAGAGHGPGHGMGHPLGHGHGPGHGPGHGTNGGPGAEPAGVAAAYPYPDGCGAWQQADIRTARDRLGWRPRIGIEESLADIWMEAACRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NB94</accession>
    <name>A0A0F7NB94_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_30155</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019003.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH85775">
        <property type="protein sequence ID" value="AKH85775"/>
        <property type="gene ID" value="AA958_30155"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_30155"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6368"/>
    <dbReference type="OrthoDB" id="2040681at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="4"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="151"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH85775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="290" mass="30750" checksum="D271614893675DF1" modified="2015-07-22" version="1">MTTRHVVVGVDGSDPSMAAVRWAAAEAAARRISLRIVHAEAASTSSPQAAPGGSLHEEWVRDRIATACRETAERYPEVEINGGATSETAVKALLDEAQDGELLVLGSRGIGAASGFFTGSVALPVVAHATGPTVLVRQDWHPDTADGGLPVVAGVDLDHGFDPVLEFAFAAAHRTGSLLRVVHMWRRSAIYAYPSALPDPKVGSDLKAVARENLDSALAGWRARYPEVEAERVLLDGEVAPRLLEQAAGAQLLVGGRRTHRHRMFPTLIGPVTHALMHHATAPVAVVPHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBC4</accession>
    <name>A0A0F7NBC4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_19510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_19510"/>
    <dbReference type="EnsemblBacteria" id="AKH84002">
        <property type="protein sequence ID" value="AKH84002"/>
        <property type="gene ID" value="AA958_19510"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_19510"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4110"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="22"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="163" mass="17123" checksum="8168754F80DC6F25" modified="2015-07-22" version="1">MLPSSASLEETSKGGPVTFIRRFDHVGITVADLDAVTAFFVGLGLEADRKMAVEGEFLDTVIGMTGARTEIVMLRPPGGGTTLELSSFTRPDHLPGSPAAPANELGLRNVAFEVHDLQAAVDHAAAGGYGLVGGIGEYEGEWRMAYVRGPEGIIVSLAERIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBF4</accession>
    <name>A0A0F7NBF4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">6-phosphogluconate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_24180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018050.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_24180"/>
    <dbReference type="EnsemblBacteria" id="AKH84798">
        <property type="protein sequence ID" value="AKH84798"/>
        <property type="gene ID" value="AA958_24180"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_24180"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5095"/>
    <dbReference type="OrthoDB" id="1194694at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015815">
        <property type="entry name" value="HIBADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000103">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_binding_2" evidence="1">
        <location>
            <begin position="15"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="304" mass="31078" checksum="43964ABA8FF55F4E" modified="2015-07-22" version="1">MTTDTHAGTAAPAPVAVLGLGLMGHALAAALLRAGHPTTVWNRTAAKADDLVAAGAVRAETPAAAVAAAPLVIACVTDYDALHAFLDPVYPDALRGRTLVNLTSGSSAQARDTAAWAGGRGLTYLDGAIMANPSAIGTGEATIVVSGPRAEFDRYAPALRALAGDIPYLGADRGLTALHEMAVVSLMWSLLNGWLHGAALVGTAGVSAVEYAAVAEKGMRAVLGWLPGYAEQIDTGTFPTDDATLDTHRAAMAHLVQESESLGVNAEFPALIKSLADRAAAAGHGGEGYPVMIEEFRRPAARPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBK1</accession>
    <name>A0A0F7NBK1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DNA-3-methyladenine glycosylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AA958_28590</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNQ-509</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018780.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_28590"/>
    <dbReference type="EnsemblBacteria" id="AKH85546">
        <property type="protein sequence ID" value="AKH85546"/>
        <property type="gene ID" value="AA958_28590"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_28590"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6023"/>
    <dbReference type="OrthoDB" id="1781735at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035451">
        <property type="entry name" value="Ada-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004026">
        <property type="entry name" value="Ada_DNA_repair_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010316">
        <property type="entry name" value="AlkA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037046">
        <property type="entry name" value="AlkA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02805">
        <property type="entry name" value="Ada_Zn_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06029">
        <property type="entry name" value="AlkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01009">
        <property type="entry name" value="AlkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57884">
        <property type="entry name" value="SSF57884"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="9">
        <location>
            <begin position="87"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AKH85546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="507" mass="53809" checksum="91E015CD7A0658E1" modified="2015-07-22" version="1">MFTDTERCVRAVQSKDARFDGWFFTGVLTTGIYCRPSCPVVPPKPQNMRFYASAAAAQQAGFRACKRCRPDTSPGSPEWNHRADLTARAMRLIADGVVDRDGVEGLAARLGYSTRQIERQLRAELGAGPLALARAQRAQTARVLIETSPLPMGDIAFAAGFSSIRTFNDTVQEVFALAPTELRRRAARSRAGAGTGGTAGATGTGGGAPGVIGLRLPFRQPLTPDNLFGHLVATAVPGVEEWRGGAYRRTLRLPYGHGIASLTPRPDHIAARLALTDQRDLAIAISRCRRLLDLDADPAAVDEQLARDPQLAELIAKAPGRRVPRTTDGAEFAVRAVLGQQVSTAAARTHAGRLVTAYGTEIEDAEGGLTHLFPEPGALAGLDPAALAMPRSRRTTLTALVAALAAGDLDLGGGSDWEQARHRLAELPGIGPWTVEVVAMRALGDPDAFPATDLGVRKAAAGLGLPGSPAALVRHSAAWRPWRAYAVQYLWAAPPAGDHPINLMPTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBK3</accession>
    <name>A0A0F7NBK3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DAO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_30605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019073.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_30605"/>
    <dbReference type="EnsemblBacteria" id="AKH85845">
        <property type="protein sequence ID" value="AKH85845"/>
        <property type="gene ID" value="AA958_30605"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_30605"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6468"/>
    <dbReference type="OrthoDB" id="912110at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="1">
        <location>
            <begin position="13"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="357" mass="36819" checksum="008B100D916A3F26" modified="2015-07-22" version="1">MVSGSPSPPRDGVVVVGAGVVGASVAYHLARLGVRVTLLDREAAPAAGVTGASFAWIGGTAGDWPGGAEDMRASVLADHRRLEAEVPDYAVRWTGSLTWTGEQSTDGTPAVPGRHRVVRDGIAALEPHLRDPPAHALHTPGDGGLDPEAMTRALIAAARARGATVLLGTPVTALETEAGRVTGARSATGFHPAATVVLAAGTGVAALSAALPAEVPVPESPAFRVRVAAPPGLVRTIVSTPEFEVREVRDGELLMTLPRVDGTSPPALARAAENALRHLRNTFRGAEACRLLDHRLGRRPMPPRGPLIGYAAPGRSAYVAVMHAAVTLAPTAGRLIAAELTTGEPPPELRRCRPPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBK9</accession>
    <name>A0A0F7NBK9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_30675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019083.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH85855">
        <property type="protein sequence ID" value="AKH85855"/>
        <property type="gene ID" value="AA958_30675"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_30675"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6483"/>
    <dbReference type="OrthoDB" id="2182419at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="299" mass="30508" checksum="6E6E6D5797ABD9A4" modified="2015-07-22" version="1">MTGARTGVRPRGGTWLITAAIVVGALLAGCVWWAVAGRDGAPVSGPGGADGAVVPGAKTVHFEQGHGLAAVRTLLRTPADVRAFAGWYPQEGIGGELRGKLLARDLDAEVLVATGWSSGCTSAGGAVLTYDENTGYAARLTDTRTYETCDSPWDVLAVFAVPEKDAGTDPRIGGAPPGPPGPAELLAFAPLGGAAAGRAPRAAEVSQPDQFGAFARPLPAAATAALESRLGSLYDSVLPGPARRFAFTGRGCGEDLLLEITSRRLRPVRAGGACRDPRPYVAVFSVPADRVPSSAVIGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBQ5</accession>
    <name>A0A0F7NBQ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Nitrate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">AA958_29015</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018849.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_29015"/>
    <dbReference type="EnsemblBacteria" id="AKH85616">
        <property type="protein sequence ID" value="AKH85616"/>
        <property type="gene ID" value="AA958_29015"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_29015"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6113"/>
    <dbReference type="OrthoDB" id="1873056at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009325">
        <property type="term" value="C:nitrate reductase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008940">
        <property type="term" value="F:nitrate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023234">
        <property type="entry name" value="NarG-like_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036197">
        <property type="entry name" value="NarG-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003816">
        <property type="entry name" value="Nitrate_red_gam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02665">
        <property type="entry name" value="Nitrate_red_gam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103501">
        <property type="entry name" value="SSF103501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00351">
        <property type="entry name" value="narI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="100"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Nitrate_red_gam" evidence="14">
        <location>
            <begin position="20"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AKH85616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="256" mass="28308" checksum="409188FB75BC3D2C" modified="2015-07-22" version="1">MTWTTALATAGEETGTGGALLWIALPYLALTVFVLGHVWRYRYDKFGWTTRSSQLYENRLLRIGSPLFHFGILVVLLGHIGGLLIPKSWTEAAGISEHAYHVTAVALGTIAGIATLGGMTILIYRRRTVGPVFSATTRNDKAMYFALAAAITLGLAATVAANVLDDGYDYRETISPWFRSVFYLQPDPALMADAPLLFQLHALSALLLFAVWPFTRLVHMLTAPVGYLTRPYIVYRSRDVQLGAHAPHRGWERTID</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBY2</accession>
    <name>A0A0F7NBY2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Acetate kinase</fullName>
            <ecNumber evidence="6">2.7.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Acetokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ackA</name>
        <name evidence="8" type="ORF">AA958_25100</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>acetate + ATP = acetyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:11352"/>
            <dbReference type="ChEBI" id="CHEBI:22191"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="6">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="6">Mg(2+). Can also accept Mn(2+).</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Metabolic intermediate biosynthesis; acetyl-CoA biosynthesis; acetyl-CoA from acetate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the acetokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.1" evidence="6"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018194.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_25100"/>
    <dbReference type="EnsemblBacteria" id="AKH84943">
        <property type="protein sequence ID" value="AKH84943"/>
        <property type="gene ID" value="AA958_25100"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_25100"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5290"/>
    <dbReference type="OrthoDB" id="537106at2"/>
    <dbReference type="UniPathway" id="UPA00340">
        <property type="reaction ID" value="UER00458"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008776">
        <property type="term" value="F:acetate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006085">
        <property type="term" value="P:acetyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00020">
        <property type="entry name" value="Acetate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004372">
        <property type="entry name" value="Ac/propionate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000890">
        <property type="entry name" value="Aliphatic_acid_kin_short-chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023865">
        <property type="entry name" value="Aliphatic_acid_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21060">
        <property type="entry name" value="PTHR21060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00871">
        <property type="entry name" value="Acetate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000722">
        <property type="entry name" value="Acetate_prop_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00471">
        <property type="entry name" value="ACETATEKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00016">
        <property type="entry name" value="ackA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01075">
        <property type="entry name" value="ACETATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01076">
        <property type="entry name" value="ACETATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="6">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="203"/>
            <end position="207"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="277"/>
            <end position="279"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="325"/>
            <end position="329"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="379"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="6">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="6">
        <location>
            <position position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH84943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="402" mass="42039" checksum="422033074941A022" modified="2015-07-22" version="1">MTGPTRILVLNSGSSSLKYQLIDMAGPAPGADRPARGIVERIGEPQARGGVPDHAAALRAVGEELAAAGHGLDAPGLLAIGHRAVHGGTRFTEPVLVDDGVLEEMEKLVPLAPLHNPANIAGIRVARELRPDLPQVAVFDTAFHATLPEHAWRYALDTATADAHAIRRYGFHGTSHAYVSRATARLLGRDPADPGDFNVIVLHLGNGASVSAVAGGRCVETSMGMTPLEGLVMGTRSGDLDPAVIFHLAREAGMDTDAIDTLLNKRSGLVGLCGDNDMREIGRRIAEGDERARLAFDVYVHRIRKYVGAYAAVLGRVDAVAFTAGVGENSAAVREASLRGLGGLGIELDSVRNAVRGSAPRVVSAPGSKVTVAVVPTDEELEIATQTRDLVRGGGPALPPPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBY6</accession>
    <name>A0A0F7NBY6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_25255</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018220.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_25255"/>
    <dbReference type="EnsemblBacteria" id="AKH84969">
        <property type="protein sequence ID" value="AKH84969"/>
        <property type="gene ID" value="AA958_25255"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_25255"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5323"/>
    <dbReference type="OrthoDB" id="975147at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16913">
        <property type="entry name" value="YkuD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041280">
        <property type="entry name" value="Big_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005490">
        <property type="entry name" value="LD_TPept_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038063">
        <property type="entry name" value="Transpep_catalytic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17964">
        <property type="entry name" value="Big_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03734">
        <property type="entry name" value="YkuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141523">
        <property type="entry name" value="SSF141523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519391" evidence="5">
        <location>
            <begin position="30"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="Big_10" evidence="7">
        <location>
            <begin position="72"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="YkuD" evidence="6">
        <location>
            <begin position="255"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="33"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH84969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="412" mass="43858" checksum="71C38326FE0EB369" modified="2015-07-22" version="1">MKVERIRRGRTRHSLAALLTGAVLVVVTACGGSGGGDGDGGKGGSGGPGSGGEEQKVSQAVVEITPKDGADAVGTQGDLKVTADKGKLVSVTVADEKGTEVEGEISENGAEWKPSGHLRTQTKYKVHAVAKDSEGLESAKDTTFTTVVPENTFIGHFTPEDGSTVGVGMPVSLNFNQPISNMEEVEEAIEVTADPDVEIEGHWFGNQRLDFRPEEYWEPGTEVTLSLRLDGVEGADGVYGEQHKDVGFEIGRRQVSTVDADSKKMKVERNGKTIKTIPVTTGAPSTPTWNGKMVITEQLEVTRMDGDTVGFGGEYDIKDVPHAQRLSTSGTFIHGNYWSGQATFGSANASHGCIGLYDARGGGDKSTPGSWFFRNSLIGDVVEVKNAKDEVIAPDNGLNGWNMSWEEWTAPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NC69</accession>
    <name>A0A0F7NC69_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">50S ribosomal protein L24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rplX</name>
        <name evidence="6" type="ORF">AA958_21230</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="3">One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the universal ribosomal protein uL24 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017571.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_21230"/>
    <dbReference type="EnsemblBacteria" id="AKH84297">
        <property type="protein sequence ID" value="AKH84297"/>
        <property type="gene ID" value="AA958_21230"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_21230"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4471"/>
    <dbReference type="OrthoDB" id="2040741at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06089">
        <property type="entry name" value="KOW_RPL26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01326_B">
        <property type="entry name" value="Ribosomal_L24_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041988">
        <property type="entry name" value="KOW_RPL26/RPL24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003256">
        <property type="entry name" value="Ribosomal_L24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005825">
        <property type="entry name" value="Ribosomal_L24/26_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12903">
        <property type="entry name" value="PTHR12903"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17136">
        <property type="entry name" value="ribosomal_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01079">
        <property type="entry name" value="rplX_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01108">
        <property type="entry name" value="RIBOSOMAL_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 4 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="KOW" evidence="5">
        <location>
            <begin position="2"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH84297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="107" mass="11708" checksum="9B95D4ACF1CBE914" modified="2015-07-22" version="1">MKIKKGDLVQVITGKDRGKQGKVIAAFPREDRVLVEGVNRVKKHTKAGQTARGSKTGGIITTEAPVHVSNVQLVVEKDGQKVVTRVGYRFDDEGNKIRVAKRTGEDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCF1</accession>
    <name>A0A0F7NCF1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_32510</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_32510"/>
    <dbReference type="EnsemblBacteria" id="AKH86160">
        <property type="protein sequence ID" value="AKH86160"/>
        <property type="gene ID" value="AA958_32510"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_32510"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6861"/>
    <dbReference type="OrthoDB" id="1020672at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="2"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="129"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="129"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH86160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="230" mass="25880" checksum="E636AD375448FA4B" modified="2015-07-22" version="1">MRIMIADDEAAIRESLERVLQVEGYDTSTVANGFAVLDGVVGADGDTLDLLILDVMMPRLGGLETCRRLRAAGRDLPVLMLTARDQVSDRVTGLDAGADDYLPKPFATEELLARVRALLRRRTPTDGESQILSFADVRLDPDRFEAWRGERPLRLTRTEFSLLHLFMSNATRVLTRDALFEAIWGFDMSATANNLQVYVSYLRRKMEAEGEPRLIYTLRGLGYTLRETPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-08-12" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCH1</accession>
    <name>A0A0F7NCH1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mutator family transposase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_32620</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Required for the transposition of the insertion element.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the transposase mutator family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86180">
        <property type="protein sequence ID" value="AKH86180"/>
        <property type="gene ID" value="AA958_32620"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_32620"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6890"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001207">
        <property type="entry name" value="Transposase_mutator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33217">
        <property type="entry name" value="PTHR33217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00872">
        <property type="entry name" value="Transposase_mut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0814">Transposable element</keyword>
    <keyword evidence="4 6" id="KW-0815">Transposition</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH86180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="130" mass="14679" checksum="51DB82FDAF555AAD" modified="2015-07-22" version="1">MKPVCTAPSEDAATSRFLEFSGDLGQEVSGDHRLWENGWAEFVPFLSFDVEIRKVICSTNAIESVNARIRRTVRARGHFPNEQAALKYVYMALMSLDPTASNCQDLWMGWGCRVGLRRARPEAKLLYSAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCR3</accession>
    <name>A0A0F7NCR3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptidase_S8 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_31480</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019219.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_31480"/>
    <dbReference type="EnsemblBacteria" id="AKH85991">
        <property type="protein sequence ID" value="AKH85991"/>
        <property type="gene ID" value="AA958_31480"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_31480"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6651"/>
    <dbReference type="OrthoDB" id="923655at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase_S8" evidence="7">
        <location>
            <begin position="209"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="978"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH85991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="1107" mass="115202" checksum="5FE0443143F1F7A1" modified="2015-07-22" version="1">MSHPAAFATATTAAPGTSTATPSGPDAGGAAAAGPGTEITLVTGDTVTLGPVADGRPTVSVTPAEGAGGSTSFTTLHEGADVYVIPDAVARLVPGVLDIELFNVTALAAMDYDDAVTDTLPLIVRGPRPLAALDEAADSRRLPSIDATAVDVPKDAAAGFAGRLTATAGPRAAAGVTKVWLDREVRAAELDWNLGMIGAPGAWESGLSGAGVDVAVLDTGIDADHPDLRGQIAAARDFTGSGSTGDPDGHGTHVASIVAGTGAAADGARRGVAHGARLLNARVLDDEGRGQSSWVIAGMEWATEQGAEVANLSLGAQPGEGDDPVALALEALTADTGTLFVAAAGNLGPFGGSIQSPGIARSALTVGAAVESGRTAFYSSVGPTRATFRAKPDLIAPGSGITAARSGGGTADPYTMMNGTSQAAPHVAGAAALLLEKHPDWSRERVKTALMTTADGEAERTQSQYAGAGMLDVPGAVSDTLAFDRGNVDFGYLRYPGGSEPRTVEFSVTNNGTEPERLDLSDNSRDVYGDDAPDDLLTVSPARVTVAPGETETITARLDPGAAPPRVYAGGVVVERDGRDTVTLPFNAYLEAPRHDIRLTVLDRNGDPWAGGTVWLANMDDYRPVSGGGSQSVHLDENGQGTARLLPGSLSVMAKVETPARDGSPATVAFAGSPEVMLDRDMEYTIDARKAKQLRPARVAGAQTEVEHVSIHYQRGDAKRGSGIGDGIYAGGEEVAEGRVFLQPTGGVESGTVAFETRWRLKATGPAHGRQADAYELVLGGEKIADPPVYDVSRAEARDLARMTSDYRSLRGGADTYAETRFAYTDRIHAAYGMSEPLDVPRRRTELVTAGPEVRWQHCLRAPSAGGLSMCGPTAPYERGEQGAPVWFRGLAPAVVAGNHYDGSLNVSVDLSDGEHNGQEPTGVFGEQSLRLYRDGTEVRPRQPGSAYFDVPSGPATYRLEHTSRPDTVRLPLGSRTETRWTFPSRGPAPGGSAVKPRLLTVDHRPPTRDDGTLRAGVPLMMGARLVSSESRSDLREEKGTLRMWVSTDSGGRWHRMLVAPTPDGSVLATAPGVRPRAGDFVSVRVEGSAAEGRTVDQTIVDAYPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCU5</accession>
    <name>A0A0F7NCU5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_31700</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019254.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_31700"/>
    <dbReference type="EnsemblBacteria" id="AKH86026">
        <property type="protein sequence ID" value="AKH86026"/>
        <property type="gene ID" value="AA958_31700"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_31700"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6694"/>
    <dbReference type="OrthoDB" id="1688736at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="89"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="278"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="89"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH86026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="315" mass="34160" checksum="CE2975E6C126E616" modified="2015-07-22" version="1">MTTQMTRVRPAAPVKERRRTRTANVADVGRPGFLWAAPATLFFAAFAVVPLIMVVVLSFMSWDGIGDPEFAGLDNWRRVLDDPVMIKSIWLSLLLTGLGVAIQTPLSILLGVWAAGNQKNRAVLSAIYFLPLLLSATAVAVVWGALLDPNFGVPAEATWLFGDGNLYGEQASAIGVLAFVSTWQFTPFHTLIYQGAARAIPPVLYQAAEVDGAGRYRQFFHITLPQLRNAMITSMILMVVGGLTTFETVLILTQGGPGTDTTISAYYMYERAFKSFDYGVGAAIALVLVLAATLISLVMVRLSGYDKMRSTTEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7ND01</accession>
    <name>A0A0F7ND01_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_26875</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018495.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_26875"/>
    <dbReference type="EnsemblBacteria" id="AKH85258">
        <property type="protein sequence ID" value="AKH85258"/>
        <property type="gene ID" value="AA958_26875"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_26875"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5653"/>
    <dbReference type="OrthoDB" id="1911275at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="6"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH85258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="229" mass="24793" checksum="230BE6F89E7CBD3D" modified="2015-07-22" version="1">MCAVNGGISQAVCSAIRDDIVSGFFAQGARLAEEHLARRYGVSRVPVREALRTLESEGFVTTKRHAGACVAEPTARDAADLLEIRALLEPLGAARAAQRRTEAHLKVLHGLVRLGRERAQRGHVAELPSLSTWFHETLAQATGSRNLTALLVQVRRKVAWLYGASPAVRTVEAWDEHGAIADAVARGDAERARSLATAHVERSAGAYELRRTVRVSSRKHAVNTGSDQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDF6</accession>
    <name>A0A0F7NDF6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_27735</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018632.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH85398">
        <property type="protein sequence ID" value="AKH85398"/>
        <property type="gene ID" value="AA958_27735"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_27735"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5845"/>
    <dbReference type="OrthoDB" id="2137426at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH85398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="297" mass="32660" checksum="F753F1E1190125AF" modified="2015-07-22" version="1">MAHGRTELGRYEARLLLWLLRESGHRPDVPVRTAAFGLEQNKPPLGVSAVIAALADRGLVDVHRWPEHTPADTSLRPEGHRRALRLERERRDPGARQEYAENAVLRWAFEHRGDEALLLRDFFVADHVFFHGDALRAGEVLAAARSLRAAGLLGLTGDGVDGDVVTGRAELTERGLDCGHAGTGLAEFLRQERERQSTYRIDTIQGPVTFISNSTVTYVGTLADELAGLGPGLGLDEERLRHLLRQGDELRRAAEEGGPGRLRALVDRIREELTSAPDTTGRQLLLDMARQVGGMLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-10-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDX2</accession>
    <name>A0A0F7NDX2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_29270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH85654">
        <property type="protein sequence ID" value="AKH85654"/>
        <property type="gene ID" value="AA958_29270"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_29270"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6171"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH85654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="113" mass="11547" checksum="A329FB3D2494FC0E" modified="2015-07-22" version="1">MDIHATQMAVQGETITTGFGKRPTGGAVPVEAVPAPSVAAPGWSSGLPSPPAGRLHARTHPGVDELILRDAGTGIAPASAAPRCCARIWRDAGIGTEAHQPKAGDVLRARAWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NE12</accession>
    <name>A0A0F7NE12_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_29585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018928.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_29585"/>
    <dbReference type="EnsemblBacteria" id="AKH85699">
        <property type="protein sequence ID" value="AKH85699"/>
        <property type="gene ID" value="AA958_29585"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_29585"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6244"/>
    <dbReference type="OrthoDB" id="1135906at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="296" mass="31651" checksum="342FF02B7C00F1A4" modified="2015-07-22" version="1">MSEAKRETPHPAEQHPRPELPAQDQPHPGWTGPMDPPPDHGEDTYRGARRLQGLKAVITGGDSGIGRAVAIAYAREGADVLLTHLPEEEDEAHETAGWVKEAGRKAVTVPCDIREESACADLIGRAAEEFGRIDLLVNNAAYQMSQPDGIEAITTEQFDRVMRTNLYGMFWLSKKALAHMGPGGGIINSASVQGYKPSPHLLDYAMTKAAIVAFTQGLAQMLTDRGIRVNAVAPGPVWTPLIPATLPDTVHFGKQSPLGRPAQPAEMAPAYVFLASPESGFITAEIVNATGGTPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NEA9</accession>
    <name>A0A0F7NEA9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GDP-mannose-dependent alpha-(1-6)-phosphatidylinositol monomannoside mannosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_06760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019833.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_06760"/>
    <dbReference type="EnsemblBacteria" id="AKH86586">
        <property type="protein sequence ID" value="AKH86586"/>
        <property type="gene ID" value="AA958_06760"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_06760"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1412"/>
    <dbReference type="OrthoDB" id="694191at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="180"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="366" mass="39127" checksum="9E33DE2E132AE583" modified="2015-07-22" version="1">MQNFLHSMCLRLDPEQVVVYASTWKRDAEGRAATRDFDARQPFEVIRDGTTMLLPTPRVTRRAAGLLRAHGCRSVWFGAAAPLGLMAPALRRAGAERIVATTHGHEAGWAQLPVARQLLRRIGESADTLTYLGEYTRARIARALTPEAAARMARLPPGVDETAFHPGSGGDAVRARLGLADRPVVVCVSRLVPRKGQDTLIRALPRILAAQPEAVLLIVGGGPYRGDLEKLAAATGVAGSVRFTGAVPWEELPAHFGAGDVFAMPCRTRRGGLDVEGLGIVYLEASATGLPVVAGDSGGAPDAVLDGETGWVVRGGAERQAAQAAEHIVTLLGDADLRARMGARGRAWVAERWRWDLLAERLTSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NED9</accession>
    <name>A0A0F7NED9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Translocation protein TolB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_09020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019890.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86631">
        <property type="protein sequence ID" value="AKH86631"/>
        <property type="gene ID" value="AA958_09020"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_09020"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1901"/>
    <dbReference type="OrthoDB" id="796397at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="PD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008557">
        <property type="entry name" value="PhoX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05787">
        <property type="entry name" value="DUF839"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH86631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="387" mass="40293" checksum="57749FEE1DA29E24" modified="2015-07-22" version="1">MERRSFLRGAVVGGSSAAFGGSLWRGSAAADPAQPGAGPYGAPGQADGNGIRLPQGFTSRVVARSGQQVAGTSYTWHPAPDGGACFADGDGWIYVSNSEVTPSGGAGSIRFTAAGEVAGAYRILSGTRQNCAGGKTPWDTWLSCEEVDRGYVYETDPWGAKAAVRRDAMGRFTHEAAAADPERRVVYLTEDVSDGCFYRFRPTTWGSLSAGTLEVLRMGSGTSGPVTWAQVPDPSGASTATRNQVAGAKRFDGGEGCHYASDSGICWFTTKGDGRVWQYDAAAQTLELAYDDSLVPGAAPLTGVDNVTGSRSGDLYVAEDGGTMEICLITPDDVVAPFLRVEGQGGSEITGPAFTPDGTRLYFSSQRGTTGSSSGGLTYEISGPFRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NEP3</accession>
    <name>A0A0F7NEP3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Alpha-L-fucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_30515</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019061.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_30515"/>
    <dbReference type="EnsemblBacteria" id="AKH85833">
        <property type="protein sequence ID" value="AKH85833"/>
        <property type="gene ID" value="AA958_30515"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_30515"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6449"/>
    <dbReference type="OrthoDB" id="439010at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004560">
        <property type="term" value="F:alpha-L-fucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006004">
        <property type="term" value="P:fucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016286">
        <property type="entry name" value="FUC_metazoa-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000933">
        <property type="entry name" value="Glyco_hydro_29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037524">
        <property type="entry name" value="PA14/GLEYA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011658">
        <property type="entry name" value="PA14_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10030">
        <property type="entry name" value="PTHR10030"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01120">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07691">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00741">
        <property type="entry name" value="GLHYDRLASE29"/>
    </dbReference>
    <dbReference type="SMART" id="SM00812">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00758">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51820">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519368" evidence="6">
        <location>
            <begin position="35"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="domain" description="PA14" evidence="7">
        <location>
            <begin position="474"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="466"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH85833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="617" mass="67789" checksum="0ACF84694A8B3B72" modified="2015-07-22" version="1">MHPPRPRITRRVTALPLLVAAALAAAALPAGAAAAPSAAPAAAPPASGPGTDHAVDDPFTSERTSWFRQDRFGMFIHFGAYSNLEGEYTRPDGSVCRDAEWIKRQCSIPNEEYEKQAATFDPADFDAEAVVGAAKDAGMRYIVITSKHHDGYAMWPTKVNSWNLRDHSAFDKRRDIMAELKKAAKEAGIKLGFYYSIWDWHDPDFADPATFPRYEKRMYAQLKELVDNYDPALLWFDGEWETDRPHNPWTAQDGERLETYLRGLDPDLVVNNRVGKRRVTDGDYGTPEQEIPGAPVDGQLWESCMTLNGHWGYARYDENWKSSASLVRNLLSTASRSGNYLLNVGPDARGRVPEPSVQRLGEMGDWLRTAGQGDAVYGAGFGGLVEQPDWGYVSRKGDKLYASVTTWPAGGGALHLKARTDIDVKSARVLGSGQQVTVTEAGDGYDLTPAGSATNEAATVIELTVDPGPTAAPGRGTGLKQEVYDNPALTGTPKVTRTDADINHSWKYTGSPAKNIPADGFGVRWTGSVEPRRSETYTLTTVSDDNVRVWLDGKLVIDNWTPHGVSVDKAQVDLKAGTRHSLRVEYAEQTGDAHMKLLWSSPGQDQQIIPRQQLYPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NEQ6</accession>
    <name>A0A0F7NEQ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">XRE family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_14890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020074.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86776">
        <property type="protein sequence ID" value="AKH86776"/>
        <property type="gene ID" value="AA958_14890"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_14890"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3138"/>
    <dbReference type="OrthoDB" id="705269at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041413">
        <property type="entry name" value="MLTR_LBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17765">
        <property type="entry name" value="MLTR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="8"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="274" mass="29645" checksum="3560399143C18D4E" modified="2015-07-22" version="1">MPTIGDLLRQWRHRRRLSQLDLALAAGVSARHVSLIETGKTNPSAAMVLRLAGHLTVPLRERNRLLLAAGFAPRYPERPLDDEALAAAGAAVARVLRAHEPYPAVAFDRRWNILRTNRAVEPFFAGVDPALLRPPVNLVRLGLDPRGFAPLVVNLDDVRTVFRARIRRQLALAPDPELTALYDELLAPGAADPPDADPVGPGPAGASDVVIPMVLRVAGRELRLFSTITTFGTPVDITLAEVAIESYYPADAETAAHFEESGGRPRPSAPDPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFG1</accession>
    <name>A0A0F7NFG1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin)</fullName>
            <ecNumber evidence="4">1.17.7.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ispG</name>
        <name evidence="5" type="ORF">AA958_24310</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + H2O + oxidized [flavodoxin] = 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + reduced [flavodoxin]</text>
            <dbReference type="Rhea" id="RHEA:43604"/>
            <dbReference type="Rhea" id="RHEA-COMP:10622"/>
            <dbReference type="Rhea" id="RHEA-COMP:10623"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:58483"/>
            <dbReference type="ChEBI" id="CHEBI:128753"/>
            <dbReference type="EC" id="1.17.7.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="4">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 5/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the IspG family.</text>
    </comment>
    <dbReference type="EC" id="1.17.7.3" evidence="4"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020377.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_24310"/>
    <dbReference type="EnsemblBacteria" id="AKH87011">
        <property type="protein sequence ID" value="AKH87011"/>
        <property type="gene ID" value="AA958_24310"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_24310"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5123"/>
    <dbReference type="OrthoDB" id="665306at2"/>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00096"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046429">
        <property type="term" value="F:4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00159">
        <property type="entry name" value="IspG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016425">
        <property type="entry name" value="IspG_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004588">
        <property type="entry name" value="IspG_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30454">
        <property type="entry name" value="PTHR30454"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04551">
        <property type="entry name" value="GcpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004640">
        <property type="entry name" value="IspG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="SSF51717"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56014">
        <property type="entry name" value="SSF56014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00612">
        <property type="entry name" value="ispG_gcpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 4" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="312"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH87011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="382" mass="40258" checksum="695D66CA88801A00" modified="2015-07-22" version="1">MPKVPQQVSPRRKSRQLRLGHDDRAVLVGGDAPVSVQSMCTTVTADVNATLQQIAELTASGCQIVRVAVPSADDADALPEIARKSQIPVIADIHFQPRYVFAAIDAGCAAVRVNPGNIKAFDDKVGEIAKAAADAQVPIRIGVNAGSLDKRLMEKYGSATPDALVESALWECSLFEEHGFRDIKISVKHHDPVVMINAYRKLAAACDYPLHLGVTEAGPEFQGTVKSAVAFGALLAEGIGDTIRVSLSAPPAEEVKVGAAILESLGLKERRLEIVSCPSCGRAQVDVYKLANEVTAGLDGMEVPLRVAVMGCVVNGPGEARDADLGVASGNGKGQIFVKGKVVATVPESKIVETLIDEAMRIAEEMEADEDTPAGTPQVITP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFN7</accession>
    <name>A0A0F7NFN7_9ACTN</name>
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        <submittedName>
            <fullName evidence="7">Nitrate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_28570</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018776.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_28570"/>
    <dbReference type="EnsemblBacteria" id="AKH85542">
        <property type="protein sequence ID" value="AKH85542"/>
        <property type="gene ID" value="AA958_28570"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_28570"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6019"/>
    <dbReference type="OrthoDB" id="326558at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012681">
        <property type="entry name" value="NCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045225">
        <property type="entry name" value="Uracil/uridine/allantoin_perm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618">
        <property type="entry name" value="PTHR30618"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00800">
        <property type="entry name" value="ncs1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="205"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="329"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="393"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="434"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="485"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH85542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="521" mass="55149" checksum="084BCC0FF111C9F0" modified="2015-07-22" version="1">MVADAASPPYPQEPADGRVELAPSDDLAGSRYANGDLLPVPAARRTWTTYNFAALWIGMAVNVPTWTLAAGLIALGMDWKQAVLTIALANVIVLLPMLLTGHAGPKYGIPFPVLARSSFGVVGANLPALLRGVVACAWFGIQTWIGGQAIYFLGGKISGAGSWWAEAGSWGGYPWPQWLCFVLFWLVEVGIILFGMEGVKKLENWAAPLMLAGAVALLIWIADQAGGFGPLLDEPSELGWGTEFWKVFFPALMGMIGFWSTLSLNIPDFTRFGAGQRAQIWGQSLGLPTTMAAFALLSVLVTSGSQAVYGKPIWEPAELAARMDTKLGVAFALFVILLATLTTNVAANLVSPAYDLSNLAPKAISFRTGSLIACAAGMLMFPWELIANPDIYIFVWLGTYGGLLGAVAGVLIADYWLVRRTALALPDLYRRDGAYWYAGGWNWRGVLAFAVGGLLAVGGSHTDAGASGPYPEDGLIPFLKPLADYGWAVGLGTSLILYTALMAGTRGKAVTAGPAGAAGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFT5</accession>
    <name>A0A0F7NFT5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_28860</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018825.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_28860"/>
    <dbReference type="EnsemblBacteria" id="AKH85592">
        <property type="protein sequence ID" value="AKH85592"/>
        <property type="gene ID" value="AA958_28860"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_28860"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6081"/>
    <dbReference type="OrthoDB" id="1339160at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="11"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="151"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH85592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="401" mass="42723" checksum="A6738E91B2E6FADA" modified="2015-07-22" version="1">MSHDTTAPALGVGMVGYAFMGAAHSQGWRTAARVFDLPLTPVMAAICGRDEDKVATAARKMGWAAAETDWRRLITRDDVQLVDVCTPGDSHAEIAIAALEAGKHVLCEKPLANTVAEAEAMVDAAARARERGQLAMVGFNYRRVPALAYARELIARGRLGALRHVRVTYLQDWLVDPEFPLAWRMQKEKAGSGALGDLGAHIVDLAQFLTGEPLVGVSAQTETFVKERPLPSAAAGLSGAAAGGGERGPVTVDDAALFTGRLASGALASFEVSRMAAGRKNALSVELNGEHGSLSFDLERLNELQLHDHAEPAETAGFRRVLVTEPEHPYLEAWWPPGHGLGYEHTFVHQVRDLVHAVATGAQPAPSFADGLQVQRVLAAVEESAEKNAVFTPVVQAGQAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFV9</accession>
    <name>A0A0F7NFV9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sugar ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_33530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019556.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_33530"/>
    <dbReference type="EnsemblBacteria" id="AKH86334">
        <property type="protein sequence ID" value="AKH86334"/>
        <property type="gene ID" value="AA958_33530"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_33530"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.7081"/>
    <dbReference type="OrthoDB" id="447734at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519462" evidence="1">
        <location>
            <begin position="30"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="421" mass="44963" checksum="C8786F8A62556544" modified="2015-07-22" version="1">MTLIHHRRSRTRAVAVPLLATALAGVALAGCGGSDGAGGGKGSVTMWTYPVIFDEAKNKAYWDGMVEKFEKENKDISVKVETYPWADRDTALGTAIASGKGPDVVYLVPDQLPKYAPNIVPAADYMPADAESDYTDFALKSVTVGEDVLGTPILTSANPLICDKRVFDAVGEDSYPETWDDLKALGPKMKDEGYYALSYTGDTAQTLNMTFYPLLWQAGGEVFAEDGESVAFDDAAGVEALTYLTEFAEEGWTPKDLLTTTPNLEQTPVAKGKVACTWTNVPADVEPFWGRENIVVQPPLTGEESVGYGTVGALSMLKGADTEAAGKWINFVARPENAADLEKGAGYFPARTSADDLYPDDELQQAVADTLPAMNAGPLEEKAREVMGVLAPELQAALLGRKSPEDALKSAAEAADAQIAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NG01</accession>
    <name>A0A0F7NG01_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_33105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="143" mass="15472" checksum="F85538BD132F894A" modified="2015-07-22" version="1">MQTPVETAARPAAQQGHGWWHFARHYVEMVVAMAAGMLVFGALVRGGLALAGLGLSAERHPELASLEMAFSMSAGMALWMRHRGHGARSTAEMCGAMFLPAAVLFPLLWLGAVSPDSLTVLEHLAMLPLMLLVMFRRRAEYGA</sequence>
</entry>
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    <accession>A0A0F7NGR6</accession>
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        <name evidence="2" type="ORF">AA958_09005</name>
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        <name type="scientific">Streptomyces sp. CNQ-509</name>
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        <lineage>
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        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CutA family.</text>
    </comment>
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_09005"/>
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        <property type="protein sequence ID" value="AKH86629"/>
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    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_09005"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03091">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="SSF54913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="106" mass="11694" checksum="9271249694022AF4" modified="2015-07-22" version="1">MTDFLTVLTTTDAREKADALARGAVEARLAACAQVSAAVTSVYRWQGAVEETREWQVLLKTTTARYAELEAHLREAHDYDEPEIIATPVTHGSAGYLAWVERQTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NGX6</accession>
    <name>A0A0F7NGX6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_11330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
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            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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    </dbReference>
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AKH86689">
        <property type="protein sequence ID" value="AKH86689"/>
        <property type="gene ID" value="AA958_11330"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_11330"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2384"/>
    <dbReference type="OrthoDB" id="1621653at2"/>
    <dbReference type="Proteomes" id="UP000034283">
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH86689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="205" mass="21993" checksum="5C8D104F87704D60" modified="2015-07-22" version="1">MPRGRYSLHDPYDGTPLGDEHFQCAPGASGWRYTARTTAPDGTATGSVDLTIDHRGRPVRLELHAAGWQVRGAALDGITWVRSDPTGEQAREGNARAQGFTGTSPAFLIATTRLLGPPSTDAPQRLRLVALTRPVLAPRTLDQAWRRTGEDTHGTDTGPLRVVNYQVSDLETGEQGEVHIAGDVVLAAPGVELEELDTPPNSLDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NIJ0</accession>
    <name>A0A0F7NIJ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_28300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020478.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH87083">
        <property type="protein sequence ID" value="AKH87083"/>
        <property type="gene ID" value="AA958_28300"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_28300"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5965"/>
    <dbReference type="OrthoDB" id="2052421at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH87083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="94" mass="10226" checksum="18E1239B60F474CA" modified="2015-07-22" version="1">MFRTPLGTRTAVAFTSQAALVRALGPEQKWVRLGEPALRALATPVGAERITVDPLLTARRPYAHFTPPRSQGEPRPQQRPAPPSSPTPQQPATH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NK60</accession>
    <name>A0A0F7NK60_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HTH tetR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_32190</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH87187">
        <property type="protein sequence ID" value="AKH87187"/>
        <property type="gene ID" value="AA958_32190"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_32190"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6797"/>
    <dbReference type="OrthoDB" id="1570162at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
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        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025996">
        <property type="entry name" value="TetR_C_WHG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13305">
        <property type="entry name" value="TetR_C_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="14"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="4">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH87187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="219" mass="23258" checksum="7FD410EC297BC6EC" modified="2015-07-22" version="1">MSEVRSGKAGYHHGDLRNALVDAASELARGGGPEAVVLREAARRVGVSPTAAYRHFANQADLLQAVKDEGQRRLADSMEKVIAETEGPPGGDPAEAAKGRLMALGLGYVRFAVTEPGMYRVAFCRVEQDRQPWNHGEGVGDLHPGDVRSFRLLIGAMDALDAAGVMRPGVRTGAEFAAWSSVHGLAMLLLDGPLSGLPPPQRDAIVTRTLTMILDGLTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MXJ0</accession>
    <name>A0A0F7MXJ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_00855</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH80955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014321.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_00855"/>
    <dbReference type="EnsemblBacteria" id="AKH80955">
        <property type="protein sequence ID" value="AKH80955"/>
        <property type="gene ID" value="AA958_00855"/>
    </dbReference>
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        </location>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="432" mass="45626" checksum="E61CFAD44412A3CD" modified="2015-07-22" version="1">MTNPGDGGRRPRRTWWRDAAVTATAFTLCLLGGVVQVDDTLTAPPAAAYLIAVASCAVLPVRHRAPMAALAATTAAGLLVPPLGLLLSPAITAPAVIAAYAYALHARTERRAAIVVSLVSAALLLATTPWFEELSWQDASRMGSVAAFPMVAGVLGHSARNRRAYLAAVEERARRAEKSRESEARRRVAEERLRIARELHDLVAHQITLAHAQATVAAHLFDSRPEQTRKSLTELVRTTSDALDDLRATVGLLRQAGDAAEPAEPAPGLSRLPTLLDSFGRAGLEVSLEQEGTARPLPPGVDLTAYRIVQEALTNVTKHAGTGSARVHLVWNRDRLNLTVADDGHGARTALDAAAPERQPGYGLIGMRERATAVGGHLSAGSRPEGGFLVSTELPLPAVRDTAGGTGADEEGDETDDAAVDAEETEETGEAQ</sequence>
</entry>
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    <accession>A0A0F7N0E4</accession>
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    <organism evidence="1 2">
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    <reference evidence="1 2" key="1">
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            <authorList>
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="AKH81446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="145" mass="15653" checksum="259057FBF10E0D76" modified="2015-07-22" version="1">MNPTTANVVTPAPARLERRGRLPWPDARALLAGTTCAWADLDGFHVAPAADLPGPAPLATHLWAWDDGGARCSRLRFDGAQALVAVLHVGDTDGGLQVRVRPGRPWDEHDHRVGPLRPEAYGLDFELLELTGPTPATFVRAVTRI</sequence>
</entry>
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    </gene>
    <organism evidence="3 4">
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="OrthoDB" id="1996962at2"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
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            <dbReference type="EMBL" id="AKH81451.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="69" mass="7227" checksum="B0F1EB382E304965" modified="2015-07-22" version="1">MSSTDLSAARWRKSSYSNGGDANCVEVSDTFPGIMPVRDSKDPDGPALVFSADGWVSFVAALKGGEFPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N191</accession>
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    <organism evidence="2 3">
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                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
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    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_02035"/>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="74"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="191" mass="20977" checksum="EAA71C4578653FDC" modified="2015-07-22" version="1">MELQQERPDLSAYLAADAVVDHEHPLVAGTAYRLREVAEAPEAYAKGAYEFIRDTIPHSNDAGDLRVTCRASDVLKARTGICYAKAHALVALLRAQGIPAGFCYQHLGVLHGLVAVRLPGRDWIRQDPRGNKPGVDAQFRLDREQLAFVPDPSAGEHDDQLVRATPHPATLEALRAATDRRHLDRILPAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N1H6</accession>
    <name>A0A0F7N1H6_9ACTN</name>
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        <submittedName>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_02500</name>
    </gene>
    <organism evidence="2 3">
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        <lineage>
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            <taxon>Actinobacteria</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AKH81229">
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    </dbReference>
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    <dbReference type="PATRIC" id="fig|444103.5.peg.535"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <end position="246"/>
        </location>
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        <location>
            <begin position="324"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="417" mass="40502" checksum="C0469A0A6AD8C1E3" modified="2015-07-22" version="1">MIPVLEIGGTHVTAALVSPRAAAVATRVRRPLDARARAGDILGAVLRCARALPAAPAGARWGVAVPGPFDYATGVALFAGVGKFESLYGVDVRAALLDGLPGSPSGVAFRNDAHAFLAGEWAAGAARGHTRAVGITLGTGVGSAFLADGTLHTTGPGLPPEGRMDLARIDGRPLEEVVSRRAILARYSVAAGAGGGTVCGGTGSGGGPGFASGSGSAGEYGGPPGEPGGEAAGASGRPRRPEGADGAFASAGAEAAVDVREIAERARAGEERARRVLDAAFGALGAELGPRLAAFGATALVVGGSMAESWDLVAPPLTTGLTAGGWRPAAGTGVHGVRAAGDPGRPEPARSPRSGGPAGGPLPPGGPGGTGEPGRTPAETRPQSPAEPPPGSRRLVRALLGEDAGLIGAAAAVGGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N1U9</accession>
    <name>A0A0F7N1U9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 10">Phosphatidylinositol phosphate synthase</fullName>
            <shortName evidence="10">PIP synthase</shortName>
            <ecNumber evidence="10">2.7.8.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 10">CDP-diacylglycerol--D-myo-inositol-3-phosphate 3-phosphatidyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">AA958_03335</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the conjugation of the 1'-hydroxyl group of D-myo-inositol-3-phosphate (also named L-myo-inositol-1-phosphate) with a lipid tail of cytidine diphosphate diacylglycerol (CDP-DAG), forming phosphatidylinositol phosphate (PIP) and CMP. PIP is a precursor of phosphatidylinositol (PI) which is an essential lipid required for cell wall formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 10">
            <text>1,2-di-(9Z-octadecenoyl)-sn-glycero-3-cytidine-5'-diphosphate + 1D-myo-inositol 3-phosphate = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:61216"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58401"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:85356"/>
            <dbReference type="ChEBI" id="CHEBI:144472"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 10">
            <text>1D-myo-inositol 3-phosphate + a CDP-1,2-diacyl-sn-glycerol = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60504"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58088"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:58401"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Contains a di-nuclear catalytic Mg(2+) center.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Phospholipid metabolism; phosphatidylinositol phosphate biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 10">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10 11">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.-" evidence="10"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014733.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_03335"/>
    <dbReference type="EnsemblBacteria" id="AKH81374">
        <property type="protein sequence ID" value="AKH81374"/>
        <property type="gene ID" value="AA958_03335"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_03335"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.709"/>
    <dbReference type="OrthoDB" id="1232102at2"/>
    <dbReference type="UniPathway" id="UPA00132"/>
    <dbReference type="UniPathway" id="UPA00220"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016780">
        <property type="term" value="F:phosphotransferase activity, for other substituted phosphate groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02241">
        <property type="entry name" value="PIP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044268">
        <property type="entry name" value="PIP_synthase_PgsA1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="10" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 11 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="30"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="52"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="179"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="CDP-DAG binding" evidence="10">
        <location>
            <begin position="29"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="206"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>a CDP-1,2-diacyl-sn-glycerol</name>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>a CDP-1,2-diacyl-sn-glycerol</name>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>a CDP-1,2-diacyl-sn-glycerol</name>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AKH81374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="238" mass="25253" checksum="18EF7591929B581A" modified="2015-07-22" version="1">MLNKYARAIFTRVFAPIAAMLLRRGVSPDTVTFVGTLGVMAGALAFFPRGEFFWGTVIITLFVFSDLIDGTMARQSGRSSRWGAFLDSTLDRAADSAVFGGIALWYAGDGDDLMMCAVAIFCLAGGQVVSYTKARGESIGLPVKVNGLMERADRLVITLVLAGFAGMESTFGIPHIDLLLPIALWAVAAGSAVTLFQRMVTVHREAAEKDAEDPLPPPAPRGGPRPDAEAAPADQESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N1X1</accession>
    <name>A0A0F7N1X1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytochrome aa3 subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AA958_06835</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cytochrome c oxidase subunit 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015328.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_06835"/>
    <dbReference type="EnsemblBacteria" id="AKH81976">
        <property type="protein sequence ID" value="AKH81976"/>
        <property type="gene ID" value="AA958_06835"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_06835"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1429"/>
    <dbReference type="OrthoDB" id="1502742at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019646">
        <property type="term" value="P:aerobic electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024791">
        <property type="entry name" value="Cyt_c/ubiquinol_Oxase_su3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000298">
        <property type="entry name" value="Cyt_c_oxidase-like_su3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035973">
        <property type="entry name" value="Cyt_c_oxidase_su3-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013833">
        <property type="entry name" value="Cyt_c_oxidase_su3_a-hlx"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11403">
        <property type="entry name" value="PTHR11403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00510">
        <property type="entry name" value="COX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81452">
        <property type="entry name" value="SSF81452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50253">
        <property type="entry name" value="COX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="141"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="COX3" evidence="9">
        <location>
            <begin position="1"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AKH81976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="206" mass="22647" checksum="E482B88498A02B74" modified="2015-07-22" version="1">MSDVATATAAVETGHAHPSVNRPNLTSVGTIIWLSSELMFFAALFAMYFTLRSVMGADFWKDQAETLNVPFALGNTTILVLSSLTCQLGVFAAERGDVKKLRMWFTVTFIMGAVFIAGQVTEYVELVHEGITLSSGPYGSVFYLTTGFHGLHVTGGLIAFLLVLGRTYAARRFTHQQATAAIVVSYYWHFVDVVWIGLFATIYLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N1Y3</accession>
    <name>A0A0F7N1Y3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peroxiredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_10635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015946.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_10635"/>
    <dbReference type="EnsemblBacteria" id="AKH82605">
        <property type="protein sequence ID" value="AKH82605"/>
        <property type="gene ID" value="AA958_10635"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_10635"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2237"/>
    <dbReference type="OrthoDB" id="1996723at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016209">
        <property type="term" value="F:antioxidant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="1">
        <location>
            <begin position="5"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="159" mass="17054" checksum="309B788857568151" modified="2015-07-22" version="1">MSERLQPGDTAPDFTLPDADGKDVSLADRRGRKVIVYFYPAALTPGCTKQACDFTDNLDVLAAAGYDVIGVSPDKPAKLAKFREKESLKVTLVGDPDKAVLEAYGAFGEKKLYGKTVTGVIRSTVVVDEHGKVERALYNVKATGHVAKLLKDLDVTAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N272</accession>
    <name>A0A0F7N272_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_03965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014841.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_03965"/>
    <dbReference type="EnsemblBacteria" id="AKH81484">
        <property type="protein sequence ID" value="AKH81484"/>
        <property type="gene ID" value="AA958_03965"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_03965"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.832"/>
    <dbReference type="OrthoDB" id="1654295at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026881">
        <property type="entry name" value="WYL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13280">
        <property type="entry name" value="WYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WYL" evidence="1">
        <location>
            <begin position="168"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="338" mass="37343" checksum="3A9729B5F90055F5" modified="2015-07-22" version="1">MAIAKAERLMCLALCLLGTGRPLSKRELRTSIEAYVEAFGPGRGTAFGSDTSGEDAFNRMFERDKDDLRELGMVIDTVEGLDGEPGYLARRDNNRLPPVTLDAEEAAALGVAAKVWQQARLAGAASGALQKLRAAGMPLAGEGDDPEAGAVEQVSALEPRIPVREAAFEPLMLACRDRRPVVFPYRKANAARPEERHVEPWQLECWRGHWYLVGHDRGRDAERVFRLSRITGRVRNRGRGFTAEVPDRVTVRETVERWAGESADRSALIRLRTGAGYPLRARAYGIREAVLPGWDELEIPYGHGLDAWLVEFGPDVVVLEPAELRADVIDRLRAVAKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2D3</accession>
    <name>A0A0F7N2D3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ppx/GppA phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_11720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016126.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_11720"/>
    <dbReference type="EnsemblBacteria" id="AKH82790">
        <property type="protein sequence ID" value="AKH82790"/>
        <property type="gene ID" value="AA958_11720"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_11720"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2464"/>
    <dbReference type="OrthoDB" id="1922611at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007511">
        <property type="entry name" value="DUF501"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37163">
        <property type="entry name" value="PTHR37163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04417">
        <property type="entry name" value="DUF501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH82790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="178" mass="18572" checksum="3F687371F9D2B0E5" modified="2015-07-22" version="1">MDKPPPPTEHTPATAADAAAVAAQLGRAPRGLRAVAHRCPCGNPDVVETSPRLPDGTPFPTLYYLTCPRANSAIGTLEADGVMKEMTARLAADPELAAAYRAAHEDYLARRDAIAELAGFPSAGGMPDRVKCLHVLVAHALAAGPGVNPLGDEALAMLPEWWAKGPCVTSEESGEDEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2F5</accession>
    <name>A0A0F7N2F5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Tat pathway signal sequence domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_04445</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="PTM">
        <text evidence="3">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014918.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_04445"/>
    <dbReference type="EnsemblBacteria" id="AKH81563">
        <property type="protein sequence ID" value="AKH81563"/>
        <property type="gene ID" value="AA958_04445"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_04445"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.937"/>
    <dbReference type="OrthoDB" id="1067869at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018905">
        <property type="entry name" value="A-galactase_NEW3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10633">
        <property type="entry name" value="NPCBM_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002518985" evidence="4">
        <location>
            <begin position="28"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase" evidence="5">
        <location>
            <begin position="37"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="NPCBM_assoc" evidence="6">
        <location>
            <begin position="486"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="3">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600917-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH81563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="595" mass="65795" checksum="5F05A70BB479DCB3" modified="2015-07-22" version="1">MTTRRQFLAAAAGGVGGAALTPAPLAAAPGSPRGDRPNIVLIVADDLGYGELGSYGQRLIRTPHLDRLADEGLRFTAAYASAPVCAPSRASLLTGLHSGRARVRENPMRGIQPSIGDADTTVAELLQARGYRTACIGKWGFGPEEPDQHSHPNYRGFEEFYGYLTHRHAHYYFPQYLWHNSRRVPLAGNGEGGRGTYAPEQFSRRALQFIRSHAEEPFFLYLSPNVPHAPSTVPDTGEYSDTDWKPEDKGHAAQVANFDRMVGQVIEELYARRIAEDTVVIVTSDNGRHEEGGVTPALFQREQGLRGYKRNLYEGGIRVPFIAWSPYRIRRGVVNRPTPHIDLLPTLAELGGAPAPRDVDGLSLAPLLTGTGPAPRHEFLYWYRNERASTPLARAADHDRIGRISEAVRAGDWKAVRFAPGKDRRAPADRWQVELYNLADDPAESVDRVADRPDIAARLVQVMRREWRDTYDREPFGVRIAAPPYAEPGRVLTVTATLHNGSGSPWTEPRVQLQVPEGWKVRAATRRPRGRLAPGAEVVTRWRVTPPKGAPAGRWELRARAAARCAGAPLTYRTRQALLTPPAKGGYFGDLPWLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2H3</accession>
    <name>A0A0F7N2H3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_04555</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">TetR is the repressor of the tetracycline resistance element; its N-terminal region forms a helix-turn-helix structure and binds DNA. Binding of tetracycline to TetR reduces the repressor affinity for the tetracycline resistance gene (tetA) promoter operator sites.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014938.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH81583">
        <property type="protein sequence ID" value="AKH81583"/>
        <property type="gene ID" value="AA958_04555"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_04555"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.960"/>
    <dbReference type="OrthoDB" id="1570162at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004111">
        <property type="entry name" value="Repressor_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003012">
        <property type="entry name" value="Tet_transcr_reg_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02909">
        <property type="entry name" value="TetR_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00400">
        <property type="entry name" value="TETREPRESSOR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="6">
        <location>
            <begin position="8"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="5">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH81583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="215" mass="22677" checksum="915D0C3CF550DB50" modified="2015-07-22" version="1">MARPRKPLLSRERIVTAALALVDAEGLQAVSTRRLAAELGVSGPSLYNHFTTKDELLDAAVDAVVAEVDLSMFADGLPWPEALLAWARSYRAALAAHPNIVPVLAQGPGRRPAALRLADAVFGGMVDAGWPPAQATRVGALMRYYVAGSALGSFAGGFVADPAAYDPADYPHLGRAHLLAEHRQEVDEGAFETGLRALVDGLKLQFAQLSGEPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2K8</accession>
    <name>A0A0F7N2K8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_01755</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014466.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_01755"/>
    <dbReference type="EnsemblBacteria" id="AKH81102">
        <property type="protein sequence ID" value="AKH81102"/>
        <property type="gene ID" value="AA958_01755"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_01755"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.383"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="11"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="270"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="305"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="481"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH81102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="886" mass="94030" checksum="9F258F3EB381EE32" modified="2015-07-22" version="1">MAETRLIHGRYRLLELLGRGGMGEVWQARDESLGRRVAVKCLKPAGQHRQGHPLATAIQERFRREARVAALLQHRGVTVVHDFGEDEGVMYLVMELLQGRNLSQLLEAGGHRPLPVGEIIDIAEQVAAALAYTHDQGVVHRDLKPANIMRLGDGTVKILDFGIARLAHDIGFTSRLTGAGGMAMGTPHYMSPEQISGGGGIDHRSDLYSLGCVLYELATGGPPFDMDDAWAILVGHRDTPPEPLRTHRPEIPEPLERVVLDLLAKAPEDRPANAGELSARLRGSRAAAEAAGRGNGAGQGSGEHGSRRESGEEGQAREKGATPGESRGSGEAGSPAWTAGLTAGARSVRAPRATPAHGRPEDALLRTWPPTNGTSPPTWPERGTGPGIPTNGTYGPGPGGAYGGPAAGAGPSSDPAHGSAAAHHPGGAPGAGHGPGAPAPGSGGAHGPGGRYGSGGAVSVHGPLPDGSGAPTGHHPFSHAPPSFHTPPHSTHPPHPYAPPTAQPGRPSTPQHVLDAFAGRHDAAVSLARLGRWEEAAAAHRALAAERAAALGGDHPDTLSSRHQTGLCLARLGRTAEALEEFRTAAAGRERRLGREHVDTLAVRQETAYALGQLNRHAEALEVYGGVLADRERTMGYEHPDTLRCRHNLAYTLSRLGRYEESYRVASEVTAVRTRVLGADHPDTLVTRYEVGHALGSLGHWEQALATYREVAAARATTLGRDHPDTQAARYEAGICLGRLGRHEEALGHYETLIADRTQTLGTRHPETLRARHIRCVTLGRLGRWQEALTEAREVTAVRERALGPEHADTLAGRREIAVALGWLNRWAEALTVHREVARARERTLGAAHSETLSSRHDEAHCLEQLGRTAEAAGVYRLAASRRASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2Y3</accession>
    <name>A0A0F7N2Y3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA primase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_12990</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016324.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_12990"/>
    <dbReference type="EnsemblBacteria" id="AKH82990">
        <property type="protein sequence ID" value="AKH82990"/>
        <property type="gene ID" value="AA958_12990"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_12990"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2734"/>
    <dbReference type="OrthoDB" id="1601056at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015330">
        <property type="entry name" value="DNA_primase/pol_bifunc_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09250">
        <property type="entry name" value="Prim-Pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00943">
        <property type="entry name" value="Prim-Pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prim-Pol" evidence="2">
        <location>
            <begin position="29"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH82990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="231" mass="24838" checksum="BD733D7588FFAB03" modified="2015-07-22" version="1">MKETPGAEATHVPRQENPREQSEELLSAALQYAEDRHWDVVPGTWMETDDGAGAPRCSCGDTACHAPGAHPARRDWKAAATASATTLRRMWSKHPRAAVLLPTGRAFDVVDVAESAGCLALARLERGRTELGPVAATPDRRMYFFVLPGATPKVIDGLHELGYASSVALDLAVRAEGDWAAAPPTRFATSGPVQWIRRPTVSNAYLPDVAELISTLAYACGRERVGARRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N345</accession>
    <name>A0A0F7N345_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Proteasome protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_05885</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015162.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_05885"/>
    <dbReference type="EnsemblBacteria" id="AKH81809">
        <property type="protein sequence ID" value="AKH81809"/>
        <property type="gene ID" value="AA958_05885"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_05885"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1231"/>
    <dbReference type="OrthoDB" id="605198at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008492">
        <property type="entry name" value="DUF774"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019151">
        <property type="entry name" value="Proteasome_assmbl_chaperone_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038389">
        <property type="entry name" value="PSMG2_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09754">
        <property type="entry name" value="PAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028754">
        <property type="entry name" value="UCP028754"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0647">Proteasome</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH81809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="308" mass="34063" checksum="F5D67FED895AEA2C" modified="2015-07-22" version="1">MSMYEWDPSGLAAVDAVLEHDSAGLTLLYHLEGFMDAGETGAQINERLLDDLPHEVVARFDHDRLVDYRARRPLMTFRRDHWAAYEVPKLELHLVRDATASPFLLMTGPEPDVEWERFAEAVREIVERLNVRLAVNFHGVPMGVPHTRPVGLTPHGNRVDLVPGHRGVFDEAQVPGSADALLEYRLGEAGHDVLGVAAHVPHYLARTPYPDAALTVLESITSATGLVLPGVAHALRSEALKVQNEIERQVDEGDEELVGMVRGLEHQYDALAGGDDRENLMAEPAELPSADELGNAFERFLAEREEGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N367</accession>
    <name>A0A0F7N367_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_05845</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015156.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH81803">
        <property type="protein sequence ID" value="AKH81803"/>
        <property type="gene ID" value="AA958_05845"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_05845"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1223"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH81803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="104" mass="10837" checksum="31DD3180E73B1ADB" modified="2015-07-22" version="1">MDYHDVVDELESAEQELGLAACDVDETEGAGLDLAGMAAELAERAEPTGAGRPGAAPAEAWDGADAAVWSARRADGLADAERAEGLPEADWQQGRRISLARCAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-10-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3C6</accession>
    <name>A0A0F7N3C6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_06250</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015227.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH81874">
        <property type="protein sequence ID" value="AKH81874"/>
        <property type="gene ID" value="AA958_06250"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_06250"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1307"/>
    <dbReference type="OrthoDB" id="990666at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH81874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="295" mass="31784" checksum="D3CEF612299578AD" modified="2015-07-22" version="1">MELQQMRYVLAVAETKSFTRAAERCLVVQSALSHQIARLEQELGTRLFERTTRRVRLTPAGEAFLPAARQCLAAAERASVEVAAAIGEVRGQLSVGVIPSVAAVDIPGTLRDFRRQYPKVRISLRVGASDELVEQVREGDIEIAFLGLPTTARPKGVEAREVGRDRLVAVVSPDHPLAGAGSVDLRRLSSEEFVDLPAKTAGRTQSDLAFSAAGLTRDVTFEVTNADFLARLVGQGLGVAMLPSAYVPQLSGVTTIQVTDAPARVEYVVWTSDSRTPAATAFLRLLNLPDAREAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3E2</accession>
    <name>A0A0F7N3E2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Mannonate dehydratase</fullName>
            <ecNumber evidence="7">4.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AA958_14220</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the dehydration of D-mannonate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-mannonate = 2-dehydro-3-deoxy-D-gluconate + H2O</text>
            <dbReference type="Rhea" id="RHEA:20097"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17767"/>
            <dbReference type="ChEBI" id="CHEBI:57990"/>
            <dbReference type="EC" id="4.2.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Carbohydrate metabolism; pentose and glucuronate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the mannonate dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.8" evidence="7"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_027773298.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_14220"/>
    <dbReference type="EnsemblBacteria" id="AKH83195">
        <property type="protein sequence ID" value="AKH83195"/>
        <property type="gene ID" value="AA958_14220"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_14220"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2993"/>
    <dbReference type="OrthoDB" id="907794at2"/>
    <dbReference type="UniPathway" id="UPA00246"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008927">
        <property type="term" value="F:mannonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006064">
        <property type="term" value="P:glucuronate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004628">
        <property type="entry name" value="Man_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30387">
        <property type="entry name" value="PTHR30387"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03786">
        <property type="entry name" value="UxuA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519738" description="Mannonate dehydratase" evidence="9">
        <location>
            <begin position="39"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="364"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00002713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00007389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AKH83195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="418" mass="45982" checksum="C4810AB9FBB6EE35" modified="2015-07-22" version="1">MESPAQDGSSRRSFLKRGSTAAAAAAIGASAGAAPAFAAPGGGGPGGGPGGNAPFPQLNWPDDVREGPDTPKLCQWMSRRPSEETVRRWRQAGITGALVTDVPAAPWDAAELRADRERVEDMGMHVTAYLISAPDSVVRGEDGRDQAIEDIKTSLRAAGEAGIGVVEYNWYVHRLKEGYYEEIDETDRIGAGYTAFDLDHEVDGVKVRDLPRPDGVPAFTREELWDHYEHFLREVMPVAEEAGVRMAVHPNDPPAAISRGNPQIMGSVADWRRMVETVDSPSNGMTVHAGVTAEVGFDSVDFLRWMCRKDRVNHIHYRNVRVDEPQVKYAEVFPDNGETDMFGFMRQLVRAGYARGILAEHPRANDFDRENGSDQSNQYKDVGGGGHGMELYDTGYARAMMQAALLMERGRYGRDDEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3J6</accession>
    <name>A0A0F7N3J6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GDP-mannose-dependent alpha-(1-2)-phosphatidylinositol mannosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_03325</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014731.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_03325"/>
    <dbReference type="EnsemblBacteria" id="AKH81372">
        <property type="protein sequence ID" value="AKH81372"/>
        <property type="gene ID" value="AA958_03325"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_03325"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.707"/>
    <dbReference type="OrthoDB" id="948440at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="3">
        <location>
            <begin position="15"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH81372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="390" mass="41847" checksum="29C77391E8759423" modified="2015-07-22" version="1">MRVGIVCPYSWEAPGGVQFHVRDLAEHLRAAGHEVSVLAPADDDTPLPEYVVWAGRAVPVPYNGSVARINFGFLSAARVRRWVRDGDFDVLHIHEPAAPSLALLACWAAKGPIVATFHMSSPRSRGMIAAYPILQSALEKISARIAVSEYARRTLVEHLGGDAVVIPNGVDVSFFAGAGPKAEWQGRTLGFIGRIDEPRKGLPVLMEAFPRILERVPDARLLVAGRGDPAEVAGHLAPGVRERVQFLGMVSDEDKARLLRSVDLYVAPNTGGESFGIILVEAMSAGAPVLAADLDAFVQVLDGGTAGEVFARGDAGDLAERAAGLLLDDARRAELRERGSRHVQRFDWSTVGADILAVYETVTQGAASVAEDERAGRWAARFGPARDREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3P8</accession>
    <name>A0A0F7N3P8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Helicase ATP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_10900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015991.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_10900"/>
    <dbReference type="EnsemblBacteria" id="AKH82651">
        <property type="protein sequence ID" value="AKH82651"/>
        <property type="gene ID" value="AA958_10900"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_10900"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2293"/>
    <dbReference type="OrthoDB" id="458022at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="34"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="407"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="407"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH82651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="593" mass="65582" checksum="CC5D0A7F9683DC75" modified="2015-07-22" version="1">MSTTSHHLSPAFPGRAPWGTAGKLRAWQEAAMDRYLQSQPRDFLAVATPGAGKTTFALTLASWLLHHHVVQQITVVAPTEHLKTQWAEAAARIGIRLDPEYSAGPVGKSYQGVAVTYAGVGVRPMLHRNRCEQRKTLVILDEIHHAGDSRSWGEACLEAFEPATRRLALTGTPFRSDTNPIPFVVYEEGNDGIRRSSADYTYGYGNALGDGVVRPVIFLSYSGNMRWRTKAGDEIAARLGEPMTKDATAQAWRTALDPRGDWMPNVLSAADRRLTEIRRGIPDAGGLVIAADQDSARAYAKLIKEITGHRATVVLSDDAGASKRIDEFTDSGDRWMVAVRMVSEGVDVPRLAVGVYATTISTPLFFAQAVGRFVRSRRRGETASVFLPTIPALLGFAHEMEVERDHVLDKPKRDGEEDPYAESEKELAEAEKQQDEETGDQDELPFEALESDAVFDRVVYEGAEFGMQAHPGSEEEQDYLGIPGLLEPDQVQLLLQKRQARQIAHSRKKPAEDADLLELPADRRPVVTHRELMELRKELNSLVGAYVHQSGKPHGVIHTELRRVCGGPPSAEATPGQIRQRIAKVREWATRMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-10-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3R8</accession>
    <name>A0A0F7N3R8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_07070</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015369.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH82019">
        <property type="protein sequence ID" value="AKH82019"/>
        <property type="gene ID" value="AA958_07070"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_07070"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1482"/>
    <dbReference type="OrthoDB" id="1439189at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="2"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH82019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="309" mass="33599" checksum="08B205DFA1BC0BA5" modified="2015-07-22" version="1">MVDLRQMRYFIAVAEELHFGRAAARLHMAQPPLSRQIRLLEGAVGARLLDRSRRSVALTAAGRVFLAEARATVRQADRAVELTLRAARGETGQLAVAFIDAAIYSVIPPVVRRFSQVRPGVELSVTELRIPDQIREVAEGRLHAGFVHPPVPDPRLAVETVFTEELAVALPAGHPLAVRDRVDVAELAGTPLIQFPREINPPLFDDIVALCRAAGYTPPSLREASPKQTVIGLVAAGLGASLLPASLENLRRDGVVYRPLAGPGLTVDTSVIWRRTDRDPVLHAFLRVVREVCRAEDAGPADPVPVPDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3T5</accession>
    <name>A0A0F7N3T5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_07010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD(P)-dependent epimerase/dehydratase family. SDR39U1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015359.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_07010"/>
    <dbReference type="EnsemblBacteria" id="AKH82008">
        <property type="protein sequence ID" value="AKH82008"/>
        <property type="gene ID" value="AA958_07010"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_07010"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1466"/>
    <dbReference type="OrthoDB" id="1566711at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013549">
        <property type="entry name" value="DUF1731"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010099">
        <property type="entry name" value="SDR39U1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08338">
        <property type="entry name" value="DUF1731"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01777">
        <property type="entry name" value="yfcH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="2">
        <location>
            <begin position="3"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1731" evidence="3">
        <location>
            <begin position="248"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH82008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="297" mass="31914" checksum="64B9E1B987AFCCFE" modified="2015-07-22" version="1">MRIAVSGSSGLIGSALVGSLRTDRHDVLRLVRREATAPDEVRWDPGKGYVDAGRLDGCDAVVHLAGAGIADRRWTENYKRVLRDSRVLGTAAVADAVASLDRPPSVFVCGSAIGYYGDTGDRRVDETAPPGRGFLADLCQEWEAATRAAEEAGIRTVHARTGLVVSRRGGTWGRLFPLFRAGLGGRLGNGRQYWSFVSLHDHIAALRHLIDTEALAGPVNLTAPEPVTNREVTAAMGRVLHRPTPFPVPAAALRVALGELAEDVIGSQRVVPRKLLDSGFAFTFPGIDETLRAALRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3W7</accession>
    <name>A0A0F7N3W7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_07220</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015398.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH82048">
        <property type="protein sequence ID" value="AKH82048"/>
        <property type="gene ID" value="AA958_07220"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_07220"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1513"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519018" evidence="3">
        <location>
            <begin position="31"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH82048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="107" mass="10710" checksum="17B23B54D1DBE2FC" modified="2015-07-22" version="1">MPPGQSGRRLLLAGLAAPLLWAAVTAPAEALSLPAAPRAAASVPVQEDAPHTTGDGKNPGRAPAMGSPGAPAVRGDDAWPAITASGVFAVSLGAAVYFFGWGRRRTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N429</accession>
    <name>A0A0F7N429_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Deaminase/reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_07630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015474.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_07630"/>
    <dbReference type="EnsemblBacteria" id="AKH82124">
        <property type="protein sequence ID" value="AKH82124"/>
        <property type="gene ID" value="AA958_07630"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_07630"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1604"/>
    <dbReference type="OrthoDB" id="1920912at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
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        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RibD_C" evidence="1">
        <location>
            <begin position="4"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="192" mass="20967" checksum="4743D6C0B6EB5414" modified="2015-07-22" version="1">MRDLVYTAFVSLDGVVDSPGGGPGEEHRSGGWVVKDLEFVPEAWSLKGEELADTTALMFGRRSYEAFAPVWPGSEDHAAYKELPKYVVSTTLSDDDLVDGWGPTSILRSTEDVAALKEGDGGAIFIHGSAELARRMSDAGLIDQYNLLVFPVLLGAGKSLFGRADRDKQMLTLRESETYSNGIMKLIYDVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N466</accession>
    <name>A0A0F7N466_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_15840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016747.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_15840"/>
    <dbReference type="EnsemblBacteria" id="AKH83435">
        <property type="protein sequence ID" value="AKH83435"/>
        <property type="gene ID" value="AA958_15840"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_15840"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3337"/>
    <dbReference type="OrthoDB" id="1919329at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029229">
        <property type="entry name" value="Alkyl_sulf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036527">
        <property type="entry name" value="SCP2_sterol-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14864">
        <property type="entry name" value="Alkyl_sulf_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55718">
        <property type="entry name" value="SSF55718"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="1">
        <location>
            <begin position="16"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="222" mass="24526" checksum="3BB5AA5B0B98E756" modified="2015-07-22" version="1">MARDGGDERRTYGQACPIAHALDMIGERWALLVVRELRLGPRRYADLQAALPGIGPSVLSQRLRDLERFGVLARRALPPPASAKVYELTEWGSELEPVFAALRTWGLRSPVIPLEGVLTSDTVLLGLRAFFQPQPHAAWSASYRIELEREVYRVEVADGELTAVRRGEEPPSPDVAVTTDHDTLQSVLSHERPLSEAVEAGELTVEGDGDVMERLVEAVQRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N484</accession>
    <name>A0A0F7N484_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome C oxidase assembly protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_15950</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome ubiquinol oxidase subunit 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016767.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_15950"/>
    <dbReference type="EnsemblBacteria" id="AKH83455">
        <property type="protein sequence ID" value="AKH83455"/>
        <property type="gene ID" value="AA958_15950"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_15950"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3360"/>
    <dbReference type="OrthoDB" id="761975at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003317">
        <property type="entry name" value="Cyt-d_oxidase_su2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43141">
        <property type="entry name" value="PTHR43141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02322">
        <property type="entry name" value="Cyt_bd_oxida_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000267">
        <property type="entry name" value="Cyt_oxidse_sub2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00203">
        <property type="entry name" value="cydB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="82"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="297"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH83455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="354" mass="38520" checksum="E75A3110D67A0D1F" modified="2015-07-22" version="1">MELHVVWFVLIAVLWTGYFFLEGFDFGVGVLTRVLARDRAERRVLINTIGPVWDGNEVWLLTAGGATFAAFPDWYATLFSGFYLPLLLILVCLIVRGVAFEYRAKRPEEHWQRNWELAIFWASLLPAFLWGVAFANIVRGVQIGPDKEYVGDVFDLLNPFALLGGLVTLFLFTFHGAVFTALKTVGDIRMRARRLAAVLGTATAALALGFLLWLQADTGDGRSLVTLIVAVAALFCAIGTVAAGREGWSFLYSGVTIVATVATLFLALYPDVMPSSLNPAWSLTAENASSTPYTLKIMTWCAGIATPVVLMYQGWTYWVFRKRIGTQHIAPEAHAAVAAGGAGADGAETGGTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-10-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4H5</accession>
    <name>A0A0F7N4H5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_08640</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015636.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH82288">
        <property type="protein sequence ID" value="AKH82288"/>
        <property type="gene ID" value="AA958_08640"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_08640"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1822"/>
    <dbReference type="OrthoDB" id="1538300at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="3">
        <location>
            <begin position="7"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="17"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH82288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="142" mass="15230" checksum="3B967C87426FB06E" modified="2015-07-22" version="1">MYAARVRTAARVIRRRPGGPELPVFDHRDHPEAGTQVPAGGVEGGELLTEAVLREIDEETGMAGVTLGAAPAVQQSPHPHTGQPQITVCFQAETAETRDDWMHAAVSGDEDRGMVFRCFFVPLERAGGLLAGDQGEFVGLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4S9</accession>
    <name>A0A0F7N4S9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fur family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_09200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Fur family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015720.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_09200"/>
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        <property type="gene ID" value="AA958_09200"/>
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    <dbReference type="KEGG" id="strc:AA958_09200"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1941"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07153">
        <property type="entry name" value="Fur_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
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        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33202">
        <property type="entry name" value="PTHR33202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01475">
        <property type="entry name" value="FUR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH82374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="141" mass="15267" checksum="9E5C6B2B3A4A4D5B" modified="2015-07-22" version="1">MTTAGPPVRGRSTRQRAAVAAALAEVDEFRSAQELHDMLRHRGESVGLTTVYRTLQSLADAGDVDVLRTTEGEAVYRRCSTGEHHHHLVCRVCGKAVEVDGPAVERWAESIASEHGFVDVAHTVEVFGTCAECAAQARARD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N561</accession>
    <name>A0A0F7N561_9ACTN</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_10235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="444103.AA958_10235"/>
    <dbReference type="EnsemblBacteria" id="AKH82543">
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        <property type="gene ID" value="AA958_10235"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_10235"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2157"/>
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        <property type="entry name" value="Aldolase_TIM"/>
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    <dbReference type="InterPro" id="IPR009334">
        <property type="entry name" value="DUF993"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06187">
        <property type="entry name" value="DUF993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="391" mass="41718" checksum="D454A59CE17A7B06" modified="2015-07-22" version="1">MTTIRLPRPGGVLEAYEPRAEPAPALATGGPRPSSRTVFAAAHVVADPYADSSPGDPDSPAAVDWDATLAFRRHLWSHGLAVAEAMDTAQRGMGLDWTRAAELMSRSAAEARAHGGRVACGAGTDQLAPQGATLAGVRAAYEEQLALVEDAGAQAVLMASRALAACARGPEDYVETYGALLRQAREPVILHWLGDMFDPALAGYWGSSDLDAATGTFLDVIAQHPDKVDGVKVSLLDASREVDLRRRLPRGVRCYTGDDFHYPELIEGDEHGFSHALLGVFDPLAPLAAEAVRTLDTGDAAGFRKIMDPTVPLARHLFQAPTRFYKTGVVFLAWLGGHQSHFTMVGGQQSARSLPHLARAYEQADALGLFPDPQLAAQRMTSFLAVHGVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N573</accession>
    <name>A0A0F7N573_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_10180</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CdaR family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015876.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_10180"/>
    <dbReference type="EnsemblBacteria" id="AKH82534">
        <property type="protein sequence ID" value="AKH82534"/>
        <property type="gene ID" value="AA958_10180"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_10180"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2143"/>
    <dbReference type="OrthoDB" id="1439158at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041522">
        <property type="entry name" value="CdaR_GGDEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17853">
        <property type="entry name" value="GGDEF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGDEF_2" evidence="3">
        <location>
            <begin position="131"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_30" evidence="2">
        <location>
            <begin position="303"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH82534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="372" mass="39757" checksum="310753DAF4EE430D" modified="2015-07-22" version="1">MVARTRVAGSLPEILVGYADLLADVSATGRLLRRPELDALRELGEQAAESGRSLRELVAGHLAETRRTWAALPGVARAASAAERARSSDAVLAAVEAAVTALGEGHERAQRLAVRQEEAERREFVDDLLYGRSDLGRLAERAERFGLRLARAHAVAVAAGDEPFADVHPLVRRIERELLGRFVERDVLLTTKEGRLVCVAGSSERALLDAFAKVALEPGSGYAVATRVAMGREHAGPGGVVRSYEEALGALDMAAALGLTQPVLHAAELLVFPVLLRDRAAMADLVRTVLGPLTQARGGAEPLLATLQTCAAAGYVNAEAARRLGVSVRTLSYRLDRICTLTGYDVADSLHRYTLETAAMGARLLGWPEEPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N599</accession>
    <name>A0A0F7N599_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_18175</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017115.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_18175"/>
    <dbReference type="EnsemblBacteria" id="AKH83815">
        <property type="protein sequence ID" value="AKH83815"/>
        <property type="gene ID" value="AA958_18175"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_18175"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3821"/>
    <dbReference type="OrthoDB" id="1531811at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="190"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="27"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="219"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="219"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH83815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="259" mass="26703" checksum="95316EDA5820330B" modified="2015-07-22" version="1">MGTIADAWTWLTTGSNWSGPTGIGVRLGEHLYLTGMSLAIACAIALPIAFWLGHVGKGGTLAINISNVGRAVPTLAVLGLLMLTPLRMHGDWPTVIALVLFAVPPLLTNAYVGIREADRDVVEAARGMGMSAPQLLGRVELPLGYPLVMTGLRSATVQVVATATLAAIAGGGGLGRIITAGFRTYNTPMVVAGAFLVAVLALVLEVVLAVAGRLLDPMRGRHDGRRGRGRRTPGDDLAAPGTEGADVPPGEQKPAPASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5F6</accession>
    <name>A0A0F7N5F6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_14680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016581.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_14680"/>
    <dbReference type="EnsemblBacteria" id="AKH83266">
        <property type="protein sequence ID" value="AKH83266"/>
        <property type="gene ID" value="AA958_14680"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_14680"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3092"/>
    <dbReference type="OrthoDB" id="1943434at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1550">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032025">
        <property type="entry name" value="DUF5063"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038312">
        <property type="entry name" value="DUF5063_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16702">
        <property type="entry name" value="DUF5063"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH83266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="220" mass="24104" checksum="BF9C1D4B86D4D96C" modified="2015-07-22" version="1">MSDATTHQATQDPDSFAVQIADSIESFIVAVTEVAKGDEPNSAVPFLLLEVSQLLLAGGRLGAHEDFVPDERYEPDTGPEPDVDELRERFAELLDPVDVYSEVFDPYVPRSTPVASRISDDLADVITDLRHGRAHYAAGRVNEALWWWQFSYLSNWGPTASACLRALQSLVAHVRLDTPLGELDGLDTDSDAALDDGRLEEEAGRVMAAEIAEPLGLRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5F9</accession>
    <name>A0A0F7N5F9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_14820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AHA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016596.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_14820"/>
    <dbReference type="EnsemblBacteria" id="AKH83281">
        <property type="protein sequence ID" value="AKH83281"/>
        <property type="gene ID" value="AA958_14820"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_14820"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3123"/>
    <dbReference type="OrthoDB" id="1914312at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013538">
        <property type="entry name" value="Activator_of_Hsp90_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08327">
        <property type="entry name" value="AHSA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="157" mass="17826" checksum="60892D7DDC080E9F" modified="2015-07-22" version="1">MTEAATRVVRRQTVVAAPLEKAFAVFTERFGDFKPREHNLLGAPIADTVFERRVGGHIYDRAEDGSECRWARVLAYEPPERVVFSWDIGPTWTLETDPENTSEVEVRFIAETPDRTRVELEHRNIDRHGPGWPSVADGVGAGEGWPLYLDRYAALFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5L5</accession>
    <name>A0A0F7N5L5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sugar phosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AA958_11205</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the stealth family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016042.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_11205"/>
    <dbReference type="EnsemblBacteria" id="AKH82704">
        <property type="protein sequence ID" value="AKH82704"/>
        <property type="gene ID" value="AA958_11205"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_11205"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2361"/>
    <dbReference type="OrthoDB" id="623081at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016772">
        <property type="term" value="F:transferase activity, transferring phosphorus-containing groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031358">
        <property type="entry name" value="Stealth_CR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021520">
        <property type="entry name" value="Stealth_CR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031357">
        <property type="entry name" value="Stealth_CR3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031356">
        <property type="entry name" value="Stealth_CR4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17101">
        <property type="entry name" value="Stealth_CR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11380">
        <property type="entry name" value="Stealth_CR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17102">
        <property type="entry name" value="Stealth_CR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17103">
        <property type="entry name" value="Stealth_CR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0270">Exopolysaccharide synthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Stealth_CR1" evidence="6">
        <location>
            <begin position="327"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="Stealth_CR2" evidence="5">
        <location>
            <begin position="364"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="Stealth_CR3" evidence="7">
        <location>
            <begin position="514"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="Stealth_CR4" evidence="8">
        <location>
            <begin position="590"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="19"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF11380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH82704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="647" mass="71436" checksum="083753F2569E8FD8" modified="2015-07-22" version="1">MTQTRSERPAAPSTAPPATGVGRPRPGPARPGPRPAYAADANGAKPGQPWLVRRYRRAVPRRVRRLVVAVASPATRHRVQRALGAVSRRVPEPGQRSVLRALRATGQLGRPGRRVVHYRGQTRLAVVADSPTPLHARNENLRLVTGALDAAGIEHFAVRGYGSVSTAVAVPASARARAVAALTALCTAHPGYVCLPDRRKRPERRVRPASDPASWEALAGAAVVRFACYYADRGGHTLLGAGYGCDVEFWAEEPYEESDPGGGSPGCGRLVAPRFNRVVESVPHDGTHVTAPGHLFTRFVLPGSLGTVPDVRTRPEMTVPLPDDLRFPIDAVYTWVDGDDPAWRRRRAEAGGVPYHAEAANDARYLNRDELRYSLRSLHLYAPWIRHVYLVTDDQAPDWLDTAHPHLTVVDHRAIFTDPGVLPTFNSHAIESQLHHIDGLAEHFLYFNDDVFLGAPLLPDRFFLPSGITRYFPSRALLPSGPPDAGDVPVSVAGKNNRALLQQRFGTYITQKMKHTPHALRRSTLAEIEERFPERHRQTAASRFRSATDLSIPSAFHHYYAAFTGRAVPGQIPYDYFDLAHPDLAARLRRLLRRRDRNVFCLNDTLSGAGDLDRQVELIRPFLEAYFPGPSPFEIPFTGPGPSPLER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5Q2</accession>
    <name>A0A0F7N5Q2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_15345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016669.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_15345"/>
    <dbReference type="EnsemblBacteria" id="AKH83356">
        <property type="protein sequence ID" value="AKH83356"/>
        <property type="gene ID" value="AA958_15345"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_15345"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3228"/>
    <dbReference type="OrthoDB" id="2076478at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010093">
        <property type="entry name" value="SinI_DNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01764">
        <property type="entry name" value="excise"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_17" evidence="1">
        <location>
            <begin position="12"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="68" mass="7677" checksum="F02403A0381FA236" modified="2015-07-22" version="1">MSTATIKPKWHTTAEVAAMLGFGLSKTKMLVLTGEIRSVKVGRNRRILPAWVDEYVNRCAEEAERWTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5V4</accession>
    <name>A0A0F7N5V4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_15625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016713.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_15625"/>
    <dbReference type="EnsemblBacteria" id="AKH83401">
        <property type="protein sequence ID" value="AKH83401"/>
        <property type="gene ID" value="AA958_15625"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_15625"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3291"/>
    <dbReference type="OrthoDB" id="1983082at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="11"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="185" mass="20883" checksum="F658B395F22094CA" modified="2015-07-22" version="1">MTVEFQRYDQSRIEEVRQTMCDIHVEVRAGDLGLTGPFYSRERFNERLSGHSTAPGWEAAIGYEDDTPVGFAYCVPLAPNTRWWKTMTTPLPDGYTTEDGHRTLALNEIVVRKPWRGTGTAQALHEHLLAPRAEQRVTLLVNPKAGGGKVQAVYERWGYDKIGEQQPFPDSPVFAAMMRAPLHRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5W4</accession>
    <name>A0A0F7N5W4_9ACTN</name>
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        <submittedName>
            <fullName evidence="2">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_08150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_08150"/>
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        <property type="protein sequence ID" value="AKH82207"/>
        <property type="gene ID" value="AA958_08150"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_08150"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1717"/>
    <dbReference type="OrthoDB" id="1054546at2"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="24"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="340" mass="36709" checksum="78FD1EB978959218" modified="2015-07-22" version="1">MHSMNTPVATVPLGTDGPRVGVQGLGCMGMSFAYGPTDADAARATLDRALELGITLYDTADMYGDGENEKFIAPFIRANRDAVTLASKFSISIDPEEPQKRVIRNDRPYLRSCIEGSLRRLGVETIDLYYMHRRDLRVPIEDTVGFMAELVQEGKVRHLGLSEVTGAELRAAHAVHPIAAVQSEWSVFSRDVERTAVPAAQELGVAFVPYSPLGRGFLTGAFVNAEKDLTADDFRRTMPRFTGGNGAKNAELLAPLRQIAEAHGATPAQIALAWVHGQAALRGMTVVPIPGTRKPSRVEENAAATVIELTEAERALLEPLAGQVAGPRYADVTFTSAGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5Z2</accession>
    <name>A0A0F7N5Z2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_15925</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016763.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_15925"/>
    <dbReference type="EnsemblBacteria" id="AKH83451">
        <property type="protein sequence ID" value="AKH83451"/>
        <property type="gene ID" value="AA958_15925"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_15925"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3355"/>
    <dbReference type="OrthoDB" id="1814511at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="104"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH83451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="293" mass="30109" checksum="26A0D6E5B11A1CB5" modified="2015-07-22" version="1">MTRASHLLTEDRPEFERLLDTALHNAEFTVGAGGGRPLNPEQLRTRALGATAEISATASAEYERYVGLRTELRRPSAGGGTLGGPDGIRFSGARGGAQGDNSSAGVAAAAAVLVPVLAGTAAVIFLLVGYLLHLMNPEPSVASSMRQAGWIFAILAAAAIVISMVALLLTAVRNGSTSIRAAASRDLTEQVDRAREEWRAALLERGIQPFIEQALAGGTEGGGPDAGPEGGGAGGGGAYPAVRTDPTATRTPRLGYSRPAFSSPDDGQSKDGPSYSSPDFTSPDYGGPEHDPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6A0</accession>
    <name>A0A0F7N6A0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nitrite reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_08960</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015684.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_08960"/>
    <dbReference type="EnsemblBacteria" id="AKH82337">
        <property type="protein sequence ID" value="AKH82337"/>
        <property type="gene ID" value="AA958_08960"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_08960"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1887"/>
    <dbReference type="OrthoDB" id="1149616at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041575">
        <property type="entry name" value="Rubredoxin_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18267">
        <property type="entry name" value="Rubredoxin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="5">
        <location>
            <begin position="22"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_2" evidence="5">
        <location>
            <begin position="308"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="Rubredoxin_C" evidence="6">
        <location>
            <begin position="421"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="239"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF18267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH82337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="502" mass="50727" checksum="B5194F7D5EFF0F51" modified="2015-07-22" version="1">MNLPVPEAAAPAGPAAPAGGRRVVIVGGGMAGTRLARQLAGAGAGVTVVGEEPHAPYNRVLLADVLAGHYAPDVIRLPDLAAGPAVRVLRGVRAVRVDRAARRVECDDGRAVPYDVLVLATGAWPVLPPLRGLFDDDGDDAGGAGVALPAGVHAFRTMDDCLALAAAATPDAAAVVVGGGLLGVSAARALARRGARVVLAQQGERLMERHLDPAAAGLLRTHLEELGVEVHTECRVRGVRTRAAAPGRPRRTARPPARRADGDGPAAPADGSAFAPAGSARVAGPGDGPAAPLTGSAATPRPAPATRAVTGVELADGYVLDARLVVLACGVRPRVGLARAAGLDVSAGVVVDDALRTSDPAVHAIGDCAQHAGVLYGLAAPALDQADLLARILTGSGPREPRYTGTRALTRLTLSAADTPLDLAAFGETEPAPGDDVVHLADATRRVYRKVVVRADRLVGGILLGDLAAVGALARAWEGDAPLPAGTPLHHLLTDHLGGSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6C4</accession>
    <name>A0A0F7N6C4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_20485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017458.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_20485"/>
    <dbReference type="EnsemblBacteria" id="AKH84170">
        <property type="protein sequence ID" value="AKH84170"/>
        <property type="gene ID" value="AA958_20485"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_20485"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4317"/>
    <dbReference type="OrthoDB" id="1809950at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="174" mass="18767" checksum="8F42BE25C4C321BB" modified="2015-07-22" version="1">MTLRYELDPAVTPALRDGICTLWADVSNAGGAVGFVPPVTPADIRPELVKHLAAMAEGRTHLIAGLDGAGRPAATAFLTLNTHRLMRHWCWLYTVMVHPGRQGTGEGRRLMAAAADAAHGLGMRGIRLTCRGGTGADTFYASCGYKEVGRVPDAIRVADDDYRDDITMWLPLHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6P2</accession>
    <name>A0A0F7N6P2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_09755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015810.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_09755"/>
    <dbReference type="EnsemblBacteria" id="AKH82467">
        <property type="protein sequence ID" value="AKH82467"/>
        <property type="gene ID" value="AA958_09755"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_09755"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2056"/>
    <dbReference type="OrthoDB" id="1756326at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="199" mass="22262" checksum="E4FFA859597B09B0" modified="2015-07-22" version="1">MRQARLIVNRLLLGACGLVLLGFGGTALLGGLDLLRRWRFPDAWPWDRPQQVLLSNADRTRWRDEGWWWPVVIAALAVILLLTLWWLLAQVRRRQLSQVLVDTESGETAQVRARALEDALSAEAGSFPGVDRASTRLVGRRTHPRTWLSLRLAPHADPAGTLVRLADEALAHARDAVGTDRLPTEVRLRATSHRAGRVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6S5</accession>
    <name>A0A0F7N6S5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Carbohydrate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_13365</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016385.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_13365"/>
    <dbReference type="EnsemblBacteria" id="AKH83054">
        <property type="protein sequence ID" value="AKH83054"/>
        <property type="gene ID" value="AA958_13365"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_13365"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2811"/>
    <dbReference type="OrthoDB" id="1604782at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="3">
        <location>
            <begin position="27"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH83054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="366" mass="38764" checksum="74022054EAF9B8F4" modified="2015-07-22" version="1">MSTPSAVRTAIDPLAGTRAPGDPEHDVLLTGTVFMDIVFTGLEGAPVRGSENWARGMGSSPGGIANMATALARLGLRTTLSASFGTDLYGDYCWESLSESEGVDLSPSRRLAGWHSPVTVSMAYEGERTMVTHEHPAPPPVCATLPRARSVVASLEAGRDEEWVRQAHAQGSRVFSDVGWDETGRWDLNALTGLRYSHAFLPNAAEAMQYTRTESPEQAVRALAELVPIAVVTKGPDGAVAVDGVSGETADVPGLLVDALDPTGAGDVFVAGFMTGTLAGWPLADRLAFANLTAALSVQHFGGSLSAPDWTEVAAWWIEAAARAKAGDADAAEVARRYDFLDGLVPALVRQRPRRRAIPTIGFRDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N723</accession>
    <name>A0A0F7N723_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Valine dehydrogenase</fullName>
            <ecNumber evidence="6">1.4.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">AA958_18465</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + L-valine + NAD(+) = 3-methyl-2-oxobutanoate + H(+) + NADH + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:30763"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.4.1.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid degradation; L-valine degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the Glu/Leu/Phe/Val dehydrogenases family.</text>
    </comment>
    <dbReference type="EC" id="1.4.1.23" evidence="6"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017159.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_18465"/>
    <dbReference type="EnsemblBacteria" id="AKH83861">
        <property type="protein sequence ID" value="AKH83861"/>
        <property type="gene ID" value="AA958_18465"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_18465"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3876"/>
    <dbReference type="OrthoDB" id="1184827at2"/>
    <dbReference type="UniPathway" id="UPA00362"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043837">
        <property type="term" value="F:valine dehydrogenase (NAD) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006095">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033524">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006096">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006097">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016211">
        <property type="entry name" value="Glu/Phe/Leu/Val_DH_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42722">
        <property type="entry name" value="PTHR42722"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00208">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02812">
        <property type="entry name" value="ELFV_dehydrog_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000188">
        <property type="entry name" value="Phe_leu_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00082">
        <property type="entry name" value="GLFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00839">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00074">
        <property type="entry name" value="GLFV_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0101">Branched-chain amino acid catabolism</keyword>
    <keyword evidence="11" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ELFV_dehydrog" evidence="13">
        <location>
            <begin position="152"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="10">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="188"/>
            <end position="193"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00017332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000188-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000188-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AKH83861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="360" mass="37860" checksum="29391EA55DA25112" modified="2015-07-22" version="1">MTDVLSTLFRSDQGGHEQVVLCQDRETGLKAVIALHSTALGPALGGTRFHDYASSDDPEQAAVLDALNLSRGMSYKNAMAGLDHGGGKAVIIGDPDQAKTEDLLLAYGRFVASLGGRYVTACDVGTYVEDMDVVARTNRWTTGRSPENGGCGDSSVLTAFGVFQGMRAVAEHLWGTPSLRGRRVGIAGVGKVGHILVDHLVADGAEVVVTDVREESVARVRAAHPGVAVVADTDALIRQPLDVYAPCALGGALSDETVRVLAAKAVCGAANNQLAHPGVEKDLADRGILYAPDYVVNAGGVIQVADELHGFDMDRARAKAARIFDTTVEIFHRAASDGVPPAVAADRIAEQRMAEARRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N763</accession>
    <name>A0A0F7N763_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytidine deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_22050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017692.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_22050"/>
    <dbReference type="EnsemblBacteria" id="AKH84430">
        <property type="protein sequence ID" value="AKH84430"/>
        <property type="gene ID" value="AA958_22050"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_22050"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4645"/>
    <dbReference type="OrthoDB" id="1895660at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="147" mass="15538" checksum="ACDFB3508149AF41" modified="2015-07-22" version="1">MTSQDDERWEALRRAARDAMSRAYAPYSRYPVGAAALVDDGRTVVGCNVENASYGVGLCAECGLVSALHATGGGRLTHFTCVNGEGQLILPCGRCRQLLSEHGGPDLLLDTPAGIRPLAELLPDAFGPFELSRLHGSQHSESGGSQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N782</accession>
    <name>A0A0F7N782_9ACTN</name>
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        <recommendedName>
            <fullName evidence="4">Putative mRNA interferase YoeB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_22165</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the YoeB family.</text>
    </comment>
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        <property type="protein sequence ID" value="AKH84450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_22165"/>
    <dbReference type="EnsemblBacteria" id="AKH84450">
        <property type="protein sequence ID" value="AKH84450"/>
        <property type="gene ID" value="AA958_22165"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_22165"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4668"/>
    <dbReference type="OrthoDB" id="2036672at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035093">
        <property type="entry name" value="RelE/ParE_toxin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009614">
        <property type="entry name" value="YoeB_toxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38039">
        <property type="entry name" value="PTHR38039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06769">
        <property type="entry name" value="YoeB_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143011">
        <property type="entry name" value="SSF143011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02116">
        <property type="entry name" value="toxin_Txe_YoeB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH84450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="87" mass="10507" checksum="FBCC732FD8325E72" modified="2015-07-22" version="1">MRSVHFDPDGWEDFLFWLASDRKKARRITRLIAEIQRTPFEGIGKPEPLKADLSGYWSRRIDDEHRLVYRADDKEVRILKARYHYSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-12-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7C4</accession>
    <name>A0A0F7N7C4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_14900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016608.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH83293">
        <property type="protein sequence ID" value="AKH83293"/>
        <property type="gene ID" value="AA958_14900"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_14900"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3140"/>
    <dbReference type="OrthoDB" id="1329591at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043740">
        <property type="entry name" value="DUF5685"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18937">
        <property type="entry name" value="DUF5685"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH83293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="356" mass="36827" checksum="859C97A4446732DE" modified="2015-07-22" version="1">MFGIIRPCRCRLPKGLAKEWLGHLCGLCLALRGQGGQVARAATNHDGLLISVLYDAQAAPAEGKAGGGWRTAGPCPLRRMRRAEVAHGDGAQLAAVVSLLLASAKIRDHVADGDGALARPVLAAPARRVAGGWEAAGARGGAGLGFDTGVLVEAVERQREVEALAGPGTSVLVVTEPTELATAAAFAHTAKLAGRPGNEAALAEAGRLFGRVAHLLDAVQDAEDDRRTGAWNPITATATPPARVRQLCDDATRGVALALADAEFTDDRLVRALLVGELERAVRRTFAHAGGGFGPPPPEFVPLGQGEEETERHTDRSGCCEGCGEMCNWCQCCGGDDDGDDGGCCDCDCGCCDCSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7C6</accession>
    <name>A0A0F7N7C6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_22405</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017755.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_22405"/>
    <dbReference type="EnsemblBacteria" id="AKH84495">
        <property type="protein sequence ID" value="AKH84495"/>
        <property type="gene ID" value="AA958_22405"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_22405"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4717"/>
    <dbReference type="OrthoDB" id="1659567at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004254">
        <property type="entry name" value="AdipoR/HlyIII-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855">
        <property type="entry name" value="PTHR20855"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03006">
        <property type="entry name" value="HlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="93"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="142"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH84495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="229" mass="24950" checksum="1867999B1DEE0664" modified="2015-07-22" version="1">MSATGEGELQRVANAAAAVLKPRLRGWLHAVMFPAALFAGVLLTAMAESPRGRLACAVYTLTACLLFGVSALYHRGDWGPRATAVLRRLDHANIFLIIAGTYTPFTILLLEGGRQQALLWFIWAAALAGIAFRVLWVGAPRWLYTPCYIAMGWAAVFFLPDFMRAGGIEVLVLVVVGGVLYSAGGVIYGIKRPNPSPRWFGFHEVFHSFTLAAFAVHYVGISLVAYRHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-10-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7M3</accession>
    <name>A0A0F7N7M3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_15610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH83398">
        <property type="protein sequence ID" value="AKH83398"/>
        <property type="gene ID" value="AA958_15610"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_15610"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH83398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="232" mass="25436" checksum="A94295BBA480B6FE" modified="2015-07-22" version="1">MMPVGANGCDCESRFAVESRSVVRRNIHSDSPHAAAWTPTFTEAPSSRSALWVEFGCSPNTRLQRSVFEVGSSQEHDPVLSAGTCLGQRLLQKIRPEQDFVPDRLEFLVALVSRLRRLPVRNFLQGPADSLRLDTLEALGNLDCILRTDAVGEEICEDPGARIGWSGGAENATRGALVRILLQPGRVLGSPKSMDKMFVRNIERSGAHGIDHVADLILPTVWSAQHDEERSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7V0</accession>
    <name>A0A0F7N7V0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AA958_23470</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. UvrD subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017930.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_23470"/>
    <dbReference type="EnsemblBacteria" id="AKH84675">
        <property type="protein sequence ID" value="AKH84675"/>
        <property type="gene ID" value="AA958_23470"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_23470"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4948"/>
    <dbReference type="OrthoDB" id="137860at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013986">
        <property type="entry name" value="DExx_box_DNA_helicase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002121">
        <property type="entry name" value="HRDC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044876">
        <property type="entry name" value="HRDC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00570">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00580">
        <property type="entry name" value="UvrD-helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00341">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="SSF47819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50967">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51217">
        <property type="entry name" value="UVRD_HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="9">
        <location>
            <begin position="3"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="UvrD-like helicase C-terminal" evidence="10">
        <location>
            <begin position="284"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="domain" description="HRDC" evidence="8">
        <location>
            <begin position="631"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="556"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="24"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AKH84675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="714" mass="77500" checksum="90973A3EB2F9FB23" modified="2015-07-22" version="1">MLAGLDPEQREVATALRGPVCVLAGAGTGKTRAITHRIAYGVRAGVLHPASVLAVTFTNRAAGEMRGRLRQLGAPGVQARTFHSAALRQLQYFWPRAVGGELPRLLERKVQLVAEAAARTRVRLDRNELRDVTGELEWAKVTQTAPEDYAAALAKTGRDAPRDPAEITGIYRGYEQLKRDRGVIDFEDVLLLTVGVLQDRPDIAEQVHRQYQHFVVDEYQDVSPLQQRLLELWLGGRDNLCVVGDASQTIYSFTGATPDHLLDFRTRHPDATVVKLVRDYRSTPQVVHLANGVLSQSTGRAAAARLELVAQRDAGPEPAFAEYADEPAEAEGTARHVRRLIDAGVAPSSIAVLYRINAQSEVYEQALADRSVPYQMRGAERFFERPEVREAGVKLRGAAVAGKNDAMLDEAGRDGDLAAQVRAVLGTMGWSPEAPAGSGAARDRWESLAALVRLAEDFARARPGAALGDLVEELAERAAAQHAPTVEGVTLASLHAAKGLEWDAVFLVGLTEGMLPITYAKTPEQIEEERRLLYVGITRARVHLSLSWALSRSPGGRASRGPSRFLTGLRPGSGRGGAAGTVSQGGVERGGAERGAAARRRRRGPVRCRVCGRTLTDAGEIKLMRCEDCPSDMDEGLYERLRDWRAVQAQRLGQPAYCVFTDKTLIAIAEAAPVNEQELSVISGVGKRKLDRYGTDVLDLCAGREPSGEPAEEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8D1</accession>
    <name>A0A0F7N8D1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_24250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018062.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_24250"/>
    <dbReference type="EnsemblBacteria" id="AKH84810">
        <property type="protein sequence ID" value="AKH84810"/>
        <property type="gene ID" value="AA958_24250"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_24250"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5110"/>
    <dbReference type="OrthoDB" id="1383554at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001441">
        <property type="entry name" value="UPP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018520">
        <property type="entry name" value="UPP_synth-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036424">
        <property type="entry name" value="UPP_synth-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291">
        <property type="entry name" value="PTHR10291"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01255">
        <property type="entry name" value="Prenyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64005">
        <property type="entry name" value="SSF64005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01066">
        <property type="entry name" value="UPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="217" mass="24722" checksum="1BA81A5401ECADA1" modified="2015-07-22" version="1">MTNLMLLPDGMRRWSKANGVSLDDGYKAMADKLVEFMDWARNDGITTLYITTSSAANFSRPEPAVTTFLVAFNDVARRTHDNCRFDFTGSLDLVPKKYLTELENLRDESNKEAGFTLHYIMGMSLTEEVIQLFNRLNGKVPELTEKILAENAYVPKQVDFLIRTGGAIRMSSFFPLMSPYAELHFSPVLFPDMTRADFDTAMTDLRGRERRYGNYPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8D9</accession>
    <name>A0A0F7N8D9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_24365</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018077.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_24365"/>
    <dbReference type="EnsemblBacteria" id="AKH84825">
        <property type="protein sequence ID" value="AKH84825"/>
        <property type="gene ID" value="AA958_24365"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_24365"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5135"/>
    <dbReference type="OrthoDB" id="872193at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013751">
        <property type="entry name" value="ACP_syn_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013747">
        <property type="entry name" value="ACP_syn_III_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08545">
        <property type="entry name" value="ACP_syn_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08541">
        <property type="entry name" value="ACP_syn_III_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACP_syn_III" evidence="3">
        <location>
            <begin position="132"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="ACP_syn_III_C" evidence="2">
        <location>
            <begin position="260"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH84825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="352" mass="36052" checksum="B4C34177045F9E4E" modified="2015-07-22" version="1">MTTPVSAPPPFPPLTPSALDFTAGGDLRLASAAVEAPPALPLAEAVRDGLISAADAELTGYRSVTVAEETSSLYDLAAGAAVSAVGRAPVPAAALGTVLFANVFPQPRPPLHNLATAVAEAVSAPAVFAAEISGGCVAGLNALVIAAQRMLATRERAALVVAGDLWSRPHIDRFNCEQGYVFADGAAAVVLARDAGFARLLSAATLTDPLLSGLHAEAPSDRTPVDITARARAFLTTRMGTEVVIGRLRSGLTATIGAALSRAGAGLADVAHVLVPAIGAPFLKRNYLDALDIPVSRTTWDYAAVTGHVGAADPFGALAHLVDHDRCRSGDLVLLVSEGLGFQWTVVLLKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8G6</accession>
    <name>A0A0F7N8G6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Protein GrpE</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">HSP-70 cofactor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">grpE</name>
        <name evidence="8" type="ORF">AA958_17595</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 5">Belongs to the GrpE family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017023.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_17595"/>
    <dbReference type="EnsemblBacteria" id="AKH83719">
        <property type="protein sequence ID" value="AKH83719"/>
        <property type="gene ID" value="AA958_17595"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_17595"/>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU004478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH83719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="263" mass="27339" checksum="4FED2660799FD6A5" modified="2015-07-22" version="1">MTEETPGFEEKPDVPTDAKTAEAQQGGPDGAGNAPAGARRADGAGPGATAGNGDANSPLAARLDETRKALDERTKDLQRLQAEYQNYRRRVERDRVAVKEVANANLLTELLPVLDDIGRARDHEELVGGFKSVAESLETVVAKMGLMQFGKEGEPFDPLIHEALMHSYSPDVSETTCVQILQPGYRIGERTIRPARVAVAEPQPGATPGSQGKEGEKPDEKQADADDGGPESAGAADGGGSDASGPAKPGSGGETDSGGPDEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8L3</accession>
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            <fullName evidence="2">Glyoxalase</fullName>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
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        <lineage>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="4"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="146" mass="16325" checksum="A3FBBA40A46C231F" modified="2015-07-22" version="1">MITNLAITTVWTTDQERSRDFFADKLGFEIRDDIEMGEGMRWITVGVPGQPDVMLALMRTTGPGLDPESAEALTTLVSKGVLGAGAFHTDDCRATYEKLRARGVDFVQEPQERPYGIEAIFRDDSGNWYSLTQRREGGLDHSKPWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8P7</accession>
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    </gene>
    <organism evidence="8 9">
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        <lineage>
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        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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        </subcellularLocation>
    </comment>
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_24835"/>
    <dbReference type="EnsemblBacteria" id="AKH84895">
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    </dbReference>
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    <dbReference type="PATRIC" id="fig|444103.5.peg.5236"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Glycosyl_transferase_4"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
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            <end position="160"/>
        </location>
    </feature>
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            <end position="187"/>
        </location>
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        </location>
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            <end position="246"/>
        </location>
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            <end position="291"/>
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            <end position="342"/>
        </location>
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            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="377"/>
            <end position="466"/>
        </location>
    </feature>
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        <location>
            <begin position="412"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH84895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="466" mass="48412" checksum="50CEC6EF0448AAEA" modified="2015-07-22" version="1">MREYLLTLCIAAAVTYLLTGPVRKFAIAAGAMPEIRDRDVHSEPTPRLGGIAMFGGMCAALLVASQLQAFERVFELNEPKALLSGAALIWLIGVLDDKWGVDALLKLGAQMIAAGVMVLQGLTILWIPVPGVGTVVLTPMQGTLLTVALVVISINAVNFVDGLDGLAAGMVGIASAAFFIYAYRIWFGYGIEAAAPAALFSAVLLGMCVGFLPHNVHPARIFMGDSGSMLLGLVLAAGAISITGQVDPDALKVFAGSEKEAVRSTVPVFIPLVLPLTILAIPMLDLVLAVVRRTWRGQSPFAADRGHLHHRLLEMGHSHMRAVLLMYFWSALVAFGMVAFSVQADNVWVVLGAVGLSAAGLVLLLMPRFAPKTPSWANRLVPPRYRRPGDAGDAPGGEGPGGDPAPAGGTAVNGANATSTASAADAASGANGAQGAPGSQGHELIPAGISGSTAVGERSRWRRTGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8U5</accession>
    <name>A0A0F7N8U5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_18955</name>
    </gene>
    <organism evidence="2 3">
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        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017223.1">
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH83928">
        <property type="protein sequence ID" value="AKH83928"/>
        <property type="gene ID" value="AA958_18955"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_18955"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3979"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="183" mass="19642" checksum="00D242126F11BD60" modified="2015-07-22" version="1">MPAEYPPADVRNAVHQLRTLAERTHHTADEVPFPDPYHPPRLCDLHDSAFAIARLLTYLVHDADTTRITGAGGRRTALDRFMITELTRAAASTGRALAALSEVIAPAGARAIDDTAPFDAVGNRTKRATPVELDWIQAAHAHLAATSRRLHQAADHLRTLQAPPVPAAAAPPAPHRPGPARSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9C2</accession>
    <name>A0A0F7N9C2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Redox-sensing transcriptional repressor Rex</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rex</name>
        <name evidence="9" type="ORF">AA958_20190</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Modulates transcription in response to changes in cellular NADH/NAD(+) redox state.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the transcriptional regulatory Rex family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_20190"/>
    <dbReference type="EnsemblBacteria" id="AKH84118">
        <property type="protein sequence ID" value="AKH84118"/>
        <property type="gene ID" value="AA958_20190"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_20190"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4252"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051775">
        <property type="term" value="P:response to redox state"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01131">
        <property type="entry name" value="Rex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009718">
        <property type="entry name" value="Rex_DNA-bd_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022876">
        <property type="entry name" value="Tscrpt_rep_Rex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35786">
        <property type="entry name" value="PTHR35786"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02629">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06971">
        <property type="entry name" value="Put_DNA-bind_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0678">Repressor</keyword>
    <keyword evidence="5 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="CoA_binding" evidence="8">
        <location>
            <begin position="51"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="190"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="62"/>
            <end position="67"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH84118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="232" mass="23787" checksum="D326FE0492975B72" modified="2015-07-22" version="1">MPTVSSEELAAAAGVNSAKLRKDFSYLGSYGTRGVGYDVEYLVYQISRELGLTQDWPVVIVGIGNLGAALAGYGGFASRGFRVAGLIDADRAMTGKQVAGLTVRHTDELEPLIKESGVSIGVIATPAGAAQAVCNRLVGAGVTSILNFAPTVLNVPEGVDVRKVDLSIELQILAFHEQRKAGEEAELREAEAAAAAARGGTPEADAVAGPSAAAKKRTGQGPDGDVPAVMPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9D7</accession>
    <name>A0A0F7N9D7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_23305</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017902.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_23305"/>
    <dbReference type="EnsemblBacteria" id="AKH84646">
        <property type="protein sequence ID" value="AKH84646"/>
        <property type="gene ID" value="AA958_23305"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_23305"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4913"/>
    <dbReference type="OrthoDB" id="1553009at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH84646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="215" mass="23356" checksum="9C2DADB76BDF3E99" modified="2015-07-22" version="1">MEMTSEAEPGGMVQESEPRLVDSFLRASFPWYGLDDAFVGPRWLQSTGGGDGAVEHGTVGHGDMPSYLAEAGMREHRFAVVVTVASRPVRRSADGTGVLEATSVSSAAWLAGSGLLSCTWPTQMERQIREEWLDQQTSVAWELADDLEGSGWSALSLPVDGEGTQFHYRESEFGWVLAGTTQNQVHLGAYGRGMSAYGLAFSVIKDITTYEDRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9E4</accession>
    <name>A0A0F7N9E4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_19845</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017349.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_19845"/>
    <dbReference type="EnsemblBacteria" id="AKH84059">
        <property type="protein sequence ID" value="AKH84059"/>
        <property type="gene ID" value="AA958_19845"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_19845"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4182"/>
    <dbReference type="OrthoDB" id="1984437at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="6"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="133" mass="14100" checksum="C9233FE08FF1D007" modified="2015-07-22" version="1">MTAPEQHASVRYVVDDVASAVDFYTTHLGFSVRTDAIPAFADVIRGPLRLLLSGPASSGARATPADTATAGRNRIHLVVDDLDTEIDRLRAAGLPFRSELVSGPGGRQILLADPSGNLVELFQPARQPPPKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9J9</accession>
    <name>A0A0F7N9J9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Regulatory protein RecX</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">recX</name>
        <name evidence="6" type="ORF">AA958_26665</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Modulates RecA activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the RecX family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018457.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_26665"/>
    <dbReference type="EnsemblBacteria" id="AKH85220">
        <property type="protein sequence ID" value="AKH85220"/>
        <property type="gene ID" value="AA958_26665"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_26665"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5611"/>
    <dbReference type="OrthoDB" id="2025178at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006282">
        <property type="term" value="P:regulation of DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01114">
        <property type="entry name" value="RecX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003783">
        <property type="entry name" value="Regulatory_RecX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33602">
        <property type="entry name" value="PTHR33602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02631">
        <property type="entry name" value="RecX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH85220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="236" mass="25508" checksum="7C2F83BF499487E9" modified="2015-07-22" version="1">MVRRTDWPLPPPDDGRPPFGGGPEDGGYGPAGDPDGSGGPGHPRRSGRGGASRRGRSRGRGEPSEDRAREMSLSPEERARAICLRLLTGSPRTRKQLADALAKRDVDAEVAEAVLDRLEAAGLIDDAAFAGAWVESRHHGRGLARRALARELRTRGVAAPVVDEAVGRLDVHTEEETARELVARKLRATRGLDRDKRIRRLAGMLARRGYGEGLAIRVVREALEAEGEEAEDLLAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9N0</accession>
    <name>A0A0F7N9N0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Trypco1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_23895</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017998.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_23895"/>
    <dbReference type="EnsemblBacteria" id="AKH84746">
        <property type="protein sequence ID" value="AKH84746"/>
        <property type="gene ID" value="AA958_23895"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_23895"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5035"/>
    <dbReference type="OrthoDB" id="2018524at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045794">
        <property type="entry name" value="Trypco1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19493">
        <property type="entry name" value="Trypco1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trypco1" evidence="2">
        <location>
            <begin position="9"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH84746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="184" mass="17263" checksum="01C8844B6D9EF3FD" modified="2015-07-22" version="1">MSSNLPQRVTLPDGTEVWVRATPLDERVAAGTRAGVPAPAGAGRGAGPDGGPGAGGGAGGGIADGDDDADLEPVADWGRLASRVAGLTPLVGGVAASVRAAAAAAAPDEVSVTFGVEISAGTGKAIALLADANTTAQLSVTLTWQPGSRPAGPSGAEPPAASTASSDTAASGASGTSSSASAPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-08-12" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9S4</accession>
    <name>A0A0F7N9S4_9ACTN</name>
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        <submittedName>
            <fullName evidence="3">NUDIX hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_20675</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017490.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH84204">
        <property type="protein sequence ID" value="AKH84204"/>
        <property type="gene ID" value="AA958_20675"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_20675"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4361"/>
    <dbReference type="OrthoDB" id="1846332at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="27"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH84204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="151" mass="17007" checksum="2C5C2FE68C1666C0" modified="2015-07-22" version="1">MKRVVARAWKLLRGPVQWRILWLTQATFMIGVTGVVRNEQGQVLLLKHRMWPDSRPWGLPTGFAVKGEEFPQTVVREVREETGLDVVPGRLVQVTSGYRLRAEIAYEARHVGGTLKLDGFEILAAEWFSPDALPEGLQEAHVRLIRAGTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NA47</accession>
    <name>A0A0F7NA47_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Growth inhibitor PemK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_16730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83582.1"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH83582">
        <property type="protein sequence ID" value="AKH83582"/>
        <property type="gene ID" value="AA958_16730"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_16730"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3520"/>
    <dbReference type="OrthoDB" id="1754531at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003477">
        <property type="entry name" value="PemK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011067">
        <property type="entry name" value="Plasmid_toxin/cell-grow_inhib"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33988">
        <property type="entry name" value="PTHR33988"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02452">
        <property type="entry name" value="PemK_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH83582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="111" mass="12329" checksum="E7CC9769F95D8D66" modified="2015-07-22" version="1">MVIRGAMYRVDLGDAKRGHEQRGRRYGLVLSPSAMPWSVATIIPTSTSAQSAAFRPELEVAGTRTRLLVDQIRTVDVAYVRGDPVHYLDHAELAEVEHAVARYLGLSSWHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NA69</accession>
    <name>A0A0F7NA69_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_16880</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH83607">
        <property type="protein sequence ID" value="AKH83607"/>
        <property type="gene ID" value="AA958_16880"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_16880"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3552"/>
    <dbReference type="OrthoDB" id="1926714at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="8"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH83607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="316" mass="32774" checksum="CCDD6B0236861CF6" modified="2015-07-22" version="1">MTTRAPAVEAAGLRKAYGGREVLAGVDLTVPAGTVYALLGPNGAGKTTTVRILTTLLPADAGTAQVAGHDIRRAPARVRAAIGVTGQFSAVDGLLTGRENLRLMADLGHLARPRAAAVTAGLLARFGLADAADRRAATYSGGMKRRLDLAMTLVSGPRLIFLDEPTTGLDPRSRRALWDVVRELVADGTTVFLTTQYLEEADRLADRIGVLDGGRLVAEGTAAELKRRVTGGHVELHVADAARAAELARRLPGAVADPAAPAVTVPYDGSLGTLRRLLAGLDDDGSVTGLAVHTPDLDDVFLALTGHAVPAGEVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NA76</accession>
    <name>A0A0F7NA76_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transcriptional regulatory protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_25150</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018202.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_25150"/>
    <dbReference type="EnsemblBacteria" id="AKH84951">
        <property type="protein sequence ID" value="AKH84951"/>
        <property type="gene ID" value="AA958_25150"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_25150"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5300"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024187">
        <property type="entry name" value="Sig_transdc_resp-reg_cit/mal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45526">
        <property type="entry name" value="PTHR45526"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006171">
        <property type="entry name" value="RR_citrat_malat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0010">Activator</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="11"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR006171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH84951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="233" mass="24592" checksum="38F2F8971B832EAC" modified="2015-07-22" version="1">MTAPGRSAPIRVLVVEDDPVAADAHRLYVERVPGFAVAGAARSRAEAVRVLDQVPVDLILLDLYLPDGHGLALLRSLRTAGHAADVIAVTSARDLAVVREGVSLGVVQYVLKPFAFATLRDRLVRYAEFHAAVGEAGGQDEVDRALAALRAPAQAALPKGLSGPTLAAVTDALRRAGDDGLTATAAGEATGTSRITARRYLEHLAEAGHAVRAPQYGQVGRPELRYRWSGSRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAC1</accession>
    <name>A0A0F7NAC1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_28305</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018729.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_28305"/>
    <dbReference type="EnsemblBacteria" id="AKH85495">
        <property type="protein sequence ID" value="AKH85495"/>
        <property type="gene ID" value="AA958_28305"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_28305"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5966"/>
    <dbReference type="OrthoDB" id="487944at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044260">
        <property type="term" value="P:cellular macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043412">
        <property type="term" value="P:macromolecule modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044238">
        <property type="term" value="P:primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007848">
        <property type="entry name" value="Small_mtfrase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05175">
        <property type="entry name" value="MTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MTS" evidence="2">
        <location>
            <begin position="207"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH85495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="388" mass="41259" checksum="BEFC8014BD90B522" modified="2015-07-22" version="1">MADHPILSWNADGRAQTARWYAAGGTPPPRRVVPADDRMCADIAYRLVCEGTAVLWQGDYHGGRQLLAALGRRIDRRATRRGRRPAAPAGGRATGPADVFHRHRQAKGHRARVLGMLLVPLEPGPRGPAVPLRRAPDVGEAAVEAYGPVTEPGAVALRELLGALGAHEWRRKGVDIPALGARVHPHYGVFSPVRGEYVDLVAEAPLPAKSLAFDVGTGTGVLAAVLARRGVERVVATDTDPRALACARDNVDRLGLADQVEVVEGNLFPPGRAPLVVCNPPWLPAKPTSALEHAVYDPGGGMLHGFLAGLTAHLEPGGEGWLVLSDLAEHLGLRGRGELHAAIEAAGLRVAARHDTRPRHRKAADPSDPLHAARAAEVTSLWRLTAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAV3</accession>
    <name>A0A0F7NAV3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">IclR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_29170</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018869.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_29170"/>
    <dbReference type="EnsemblBacteria" id="AKH85640">
        <property type="protein sequence ID" value="AKH85640"/>
        <property type="gene ID" value="AA958_29170"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_29170"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6150"/>
    <dbReference type="OrthoDB" id="370329at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="4">
        <location>
            <begin position="25"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="5">
        <location>
            <begin position="87"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH85640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="273" mass="28446" checksum="31538A6B7A46DE06" modified="2015-07-22" version="1">MPAPAGQPPPGRSPGTARTPSRSSRSAADRLLAVLGAFDHAHPALSLTEIAQRADLSLATAHRLAGALAAWGALERDERGGYHIGLRLWELAALAPRGPALREAALPYLEDLYESTHENVHLAVRDGLDVVYLERISGRAAVGVRSRVGARWPLHATGVGLVLLAHSPAAVQEQVCARPLAAFTPYTLSDSDSLRRALAEVRRTGCAVSDRQITDDALSVAAPVRGPRGAVVASVSLVVHAAGAQPPALIPAVRLAGRGISRALGWRPGAAPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAY6</accession>
    <name>A0A0F7NAY6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AA958_18335</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017141.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_18335"/>
    <dbReference type="EnsemblBacteria" id="AKH83842">
        <property type="protein sequence ID" value="AKH83842"/>
        <property type="gene ID" value="AA958_18335"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_18335"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3852"/>
    <dbReference type="OrthoDB" id="1552415at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="122"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="8">
        <location>
            <begin position="29"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH83842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="273" mass="28354" checksum="DBA5BA2FAEF12892" modified="2015-07-22" version="1">MTATTAATPPAHPDDRAADVPGPLARLAAIGRAELTLMWRSKLILFGALVTPAGFAFATRSAVEEMDLSDTGLTAATVVLPSAVVFALIFVVYANLVIVYVARREELVLKRLRTGLLTDRELLAGAALPALCVALGQCLVLAVAVSLAMDSPAPEAPHLAVLGVLLGMAMLTVLAAATAAVTKSAESAQLTSMPLLLVSMFGSGLFVPFEVLPDSVAEVAQRLPLSPVVELVRGGWTGELGGGAVVQALAVAAAWIAAGAWAVRRWFRWEPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NB06</accession>
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        <recommendedName>
            <fullName evidence="2">Transglut_core2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_23220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0162 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_23220"/>
    <dbReference type="EnsemblBacteria" id="AKH84629">
        <property type="protein sequence ID" value="AKH84629"/>
        <property type="gene ID" value="AA958_23220"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_23220"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4895"/>
    <dbReference type="OrthoDB" id="1023028at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032698">
        <property type="entry name" value="SirB1_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13369">
        <property type="entry name" value="Transglut_core2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transglut_core2" evidence="2">
        <location>
            <begin position="45"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH84629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="289" mass="30707" checksum="000815CE6B1AC0DE" modified="2015-07-22" version="1">MSTSGVGHRARFAEEARVPRPDLALLCLLVGAETDPGLDEGGIDAVQIELDELAGQLPYAPGGPRAWAQAAAELLGERYGFHGTPGDYRRLESSQLHEVLRRRRGLPIMLSVIWMEVARRAGAPVYGVALPGHFVVGFGPSPAGQPLADHPAGGGPVLADPFDGGRLLSTADAELLVAEATGGEPLSPAMLVPADPLAIVLRVLNNIRAWAARRPEQSDVQLTAVELALLLPSHPARLRHERARLLIARGDFATGAAELEEYAAVIAAMEPQAAETLRREARAARARLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBA0</accession>
    <name>A0A0F7NBA0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_19285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017267.1">
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH83972">
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        <property type="gene ID" value="AA958_19285"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_19285"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4056"/>
    <dbReference type="OrthoDB" id="2020336at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519458" evidence="1">
        <location>
            <begin position="35"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="189" mass="19971" checksum="129FCE1543F020C5" modified="2015-07-22" version="1">MRKAALLVSSIALIGGSALASTSASATATQPAPAQSKYAAQAEGAGLTTAQAAKLQNKMDRYVARTGGTQVAINKIDLNGKGVVLVPLPGQDRAREISADGDVGALYTCNYYHFCAYSGTYYTGSVIDMYYCRSYSIPWAGNGSWDNNQSTGTRARMYGSSGNLIYTTPGAHSWDAVGNWTPVFTVRPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBB5</accession>
    <name>A0A0F7NBB5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_19450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017287.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_19450"/>
    <dbReference type="EnsemblBacteria" id="AKH83992">
        <property type="protein sequence ID" value="AKH83992"/>
        <property type="gene ID" value="AA958_19450"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_19450"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4089"/>
    <dbReference type="OrthoDB" id="1275854at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH83992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="226" mass="24105" checksum="413D78CE6E3CDB70" modified="2015-07-22" version="1">MALLAGPYGPPVQPPAPLLALEGVPGAGAGEVAYQIAHQLTDPNKEKTAKYTVVNLVPDSVRSWPAMATANTRPLPHLARHAAGLLHASDTIRGHLDISAAVIANRWTNTLLACHAAASGATIQQAQTVLDPVRGYLAKPTRTFYLITSAETLRKRLAAKHDVTPFAQGLLHARGRLEHVQDHFKALAATDPTSVVLHADGRTPEELAEEIIRTAQIEAAEMALQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBB8</accession>
    <name>A0A0F7NBB8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TIR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_27760</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018635.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_27760"/>
    <dbReference type="EnsemblBacteria" id="AKH85401">
        <property type="protein sequence ID" value="AKH85401"/>
        <property type="gene ID" value="AA958_27760"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_27760"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5851"/>
    <dbReference type="OrthoDB" id="45379at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003953">
        <property type="term" value="F:NAD+ nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019677">
        <property type="term" value="P:NAD catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
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        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13676">
        <property type="entry name" value="TIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00255">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="SSF52200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50104">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TIR" evidence="2">
        <location>
            <begin position="59"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH85401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="199" mass="21601" checksum="5966E61332C77B33" modified="2015-07-22" version="1">MNVAGLVLTIVGTLATLAGTYVAVREYLRRRPRITAPSPEPAPAPAPAPAAAADPAADPPYDVFIAYADTDAPWVRDFAAFLTARGVRVAYDELLAQPGGVRVHTLERAIRDAAHGLLVFGPGMRDDGWVRREYAALMRRSLENEAQRFVPVLIGDPGESLDLPEFAEVLYPADFRGADEAAYDRLCEQISRAVLTNRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBN7</accession>
    <name>A0A0F7NBN7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Crystallin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_24595</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018110.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH84858">
        <property type="protein sequence ID" value="AKH84858"/>
        <property type="gene ID" value="AA958_24595"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_24595"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5187"/>
    <dbReference type="OrthoDB" id="1661477at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4080.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005502">
        <property type="entry name" value="Ribosyl_crysJ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036705">
        <property type="entry name" value="Ribosyl_crysJ1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03747">
        <property type="entry name" value="ADP_ribosyl_GH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101478">
        <property type="entry name" value="SSF101478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH84858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="335" mass="35372" checksum="BFB1BF2C69A71CE8" modified="2015-07-22" version="1">MTRATGALLGLAIGDAMGFPTEFNTFARIEAEFGEWRSLPLPVSSGTAYVTDDTQMTLALGEALHTVLAGGPLTAGRMEPPVRAHFLSWYHSPENNRAPGGTCLRACEALERGGPWQRASVVGSKGCGANVRVAPIGLVPGMSAEQRSGAAQLQSGLTHGHPTALAAGDVTAHTVHLLVQGTDPQDLLPLLRAYAEANRTVYRADWLGDLAEHAQDVDRVSFISRGWQECLAVLDRVEAALPDADPDADPCLATGEGWIAEEAFATALFCFLQHPDDPPAAVRRGAYSGGDSDSIAALAGAFAGACHGAAAWPPEWVEVIEYRERLLALGAAWDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBP2</accession>
    <name>A0A0F7NBP2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Potassium transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_30955</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_30955"/>
    <dbReference type="EnsemblBacteria" id="AKH85900">
        <property type="protein sequence ID" value="AKH85900"/>
        <property type="gene ID" value="AA958_30955"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_30955"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6541"/>
    <dbReference type="OrthoDB" id="941006at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015299">
        <property type="term" value="F:solute:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006812">
        <property type="term" value="P:cation transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="150"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="215"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="286"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="328"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="353"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="Na_H_Exchanger" evidence="6">
        <location>
            <begin position="17"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="391"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH85900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="453" mass="46430" checksum="A068EE1567F62F63" modified="2015-07-22" version="1">MHSYAVFLIEFGAIILGLGLLGRFAGRFQFSPIPLYLLAGLAFGEGGLLPLGASEDFVAIGAEIGVILLLLMLGLEYTASDLVSNLKTQYPAGLVDFTFNALPGAIMALLLGWGGVAAVVLAGVTWISSSGVIAKVLGDLGRLGNRETPVILSVLVLEDLAMAVYLPIVTALVAGVGIAQGSATLAIALGAAGAVLFIAVRYGRLISRFVSSDDPEKLLLVVLGLTLLVAGFAQQLQVSAAVGAFLVGIALSGEVAEGAHNLLSPLRDLFAAVFFVFFGLHTDPQSIPPVILPALALAVVTALTKIATGHWAAKRAGISEKGRWRAGGTLVARGEFSIVIAGIAVTAGVEPELGPLATAYVLVLVIVGPLAARYTEPVALRVTAWREERQAERAAPAAEHAAAPVEAADARAGSPGDEEGHAEAGAAEVPRLPAQRGETAPVEDERSPGSGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBV8</accession>
    <name>A0A0F7NBV8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_25000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018175.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_25000"/>
    <dbReference type="EnsemblBacteria" id="AKH84924">
        <property type="protein sequence ID" value="AKH84924"/>
        <property type="gene ID" value="AA958_25000"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_25000"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5268"/>
    <dbReference type="OrthoDB" id="1134430at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005129">
        <property type="entry name" value="GTPase_ArgK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00750">
        <property type="entry name" value="lao"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="320" mass="33040" checksum="D3FD9B5B97FBBFA2" modified="2015-07-22" version="1">MPAADVAALVAAAREGGPRAVARLITLVEGASPHLREVMAALAPLAGRAYVVGLTGAPGVGKSTSTSALVTAYRRRGKRVGVLAVDPSSPFSGGALLGDRVRMGVHASDPGVYIRSMATRGHLGGLAWSAPQAIRVLDAAGCDVVLVETVGVGQSEVDIAGQADTCVVLLAPGMGDGIQAAKAGILEIGDVYVVNKADRDGADATARELNHMLGLGEARAPGDWRPPIVKTVAARDEGTDEVVEALEKHRAWMEEHGVLAARRLRRAAGEVETIAVTALRERIADLHGDRRLSALAERITAGELDPYAAADELLEGLTGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBX5</accession>
    <name>A0A0F7NBX5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_29685</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018939.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_29685"/>
    <dbReference type="EnsemblBacteria" id="AKH85711">
        <property type="protein sequence ID" value="AKH85711"/>
        <property type="gene ID" value="AA958_29685"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_29685"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6267"/>
    <dbReference type="OrthoDB" id="1796334at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="5">
        <location>
            <begin position="2"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="326"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH85711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="351" mass="37432" checksum="11879B0E70231DB6" modified="2015-07-22" version="1">MVTIGDIAHAAGVSRSTASYALSGKRSISAEVRQRVADAARELGYTPNAGARALATAETMVLGLLAQFHEDEFAPAMLQYMLGVSDTARELGYDTLLVTEADGARALRRITDSRMVDGVVLLNVAQDDARLPLLRDAPQPGALVGLPGDPTGVDVFDLDFEAAGRAMVDHMHRLHHRELILVSQPEHVIERGGAYVWRLQDAVVQQARFRGIRLHAAFGFSRQPGVGRHLSALLDAHPAATGLLLNNEAAAAALPSVLHARGLRVSRDLSVIGRYSDEFARTFSLPFSSIESAPDLLGALAVRQLVSRLVSPAARDEPHVLRLVPPELVDRGSTGAPPADPSTARAQGGTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NC67</accession>
    <name>A0A0F7NC67_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP-dependent DNA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_31990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
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        <property type="entry name" value="LigD_pol_dom"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0436">Ligase</keyword>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="336" mass="37997" checksum="31AA30B4003EB544" modified="2015-07-22" version="1">MGAAIQLQAGDRTVRLSSPDRVFFPAKGYTKLDLARYYVAVGDGIVRALRDRPTTLERYPEGIGGESFFQKRAPKNTPDWIPTARITFPSGRYADEMCPTEPAAVVWAAQYGTLTFHPWPVRRGDTEHPDELRIDLDPQPGTDYADAVRAAYEMRAVLGEHGLTCWPKTSGGRGMHLFVPIAPRWTFVQVRRAVIAAGRELERRMPEQVTTAWWKEERGEKVFVDYNQMARDRTIASAYSVRPHPHAPVSAPLRWEEVDAAEPDDFDLVTMVKRFAEVGDVHADMDEHAFDITSLLELSARQERDHGHGDMPYPPDHPKMAGEPKRVQPSRARPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NC95</accession>
    <name>A0A0F7NC95_9ACTN</name>
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        <submittedName>
            <fullName evidence="4">Nitrogen regulatory protein P-II 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_25895</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_25895"/>
    <dbReference type="EnsemblBacteria" id="AKH85084">
        <property type="protein sequence ID" value="AKH85084"/>
        <property type="gene ID" value="AA958_25895"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_25895"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5453"/>
    <dbReference type="OrthoDB" id="2021322at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006808">
        <property type="term" value="P:regulation of nitrogen utilization"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002187">
        <property type="entry name" value="N-reg_PII"/>
    </dbReference>
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        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
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        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002332">
        <property type="entry name" value="N-reg_PII_urydylation_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30115">
        <property type="entry name" value="PTHR30115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00543">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039144">
        <property type="entry name" value="GlnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00340">
        <property type="entry name" value="PIIGLNB"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00496">
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    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="O-UMP-tyrosine" evidence="2">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR039144-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR602187-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH85084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="112" mass="12225" checksum="5F16920CF397E105" modified="2015-07-22" version="1">MKLITAVIKPHRLDEVKEALQAFGVQGLTVTEASGYGRQRGHTEVYRGAEYTVDLVPKVRIEVLVEDDDAEQLVEVVVKAARTGKIGDGKVWSVPVDTAVRVRTGERGPDAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCF3</accession>
    <name>A0A0F7NCF3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">30S ribosomal protein S16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rpsP</name>
        <name evidence="5" type="ORF">AA958_25920</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the bacterial ribosomal protein bS16 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_25920"/>
    <dbReference type="EnsemblBacteria" id="AKH85088">
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        <property type="gene ID" value="AA958_25920"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_25920"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5458"/>
    <dbReference type="OrthoDB" id="1937072at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00385">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000307">
        <property type="entry name" value="Ribosomal_S16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020592">
        <property type="entry name" value="Ribosomal_S16_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023803">
        <property type="entry name" value="Ribosomal_S16_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12919">
        <property type="entry name" value="PTHR12919"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00886">
        <property type="entry name" value="Ribosomal_S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54565">
        <property type="entry name" value="SSF54565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00002">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00732">
        <property type="entry name" value="RIBOSOMAL_S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="85"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="120"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH85088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="162" mass="17584" checksum="2CF322DEDDE56F73" modified="2015-07-22" version="1">MAVKIKLKRLGKIRSPHYRIVVADSRTRRDGRAIEEIGLYHPVQNPSRIEVDSERAQYWLGVGAQPTEPVLAILKVTGDWQKFKGLPAPEPMKVPEPKADKRALFEAAAKDAADEPKGGAVTPKAKKADKAEKSEKAEKAEKKAEKKADAEPGEAAAEAPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCJ3</accession>
    <name>A0A0F7NCJ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_31055</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019144.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_31055"/>
    <dbReference type="EnsemblBacteria" id="AKH85916">
        <property type="protein sequence ID" value="AKH85916"/>
        <property type="gene ID" value="AA958_31055"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_31055"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6563"/>
    <dbReference type="OrthoDB" id="1812408at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="277"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="86"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="295"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="346"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH85916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="375" mass="41629" checksum="6C729C89A5815000" modified="2015-07-22" version="1">MGEMMQPGDFMMATRSRGYSPQQVDRVVGDLLAEREAAVRHARDLEARVEASGRHLAQLLEQAAALGPQTYESLGETARKLFLDAKAEADRVLARAAEECRELKEAARAAATERAKESERHAERIRADAEQRARQRIKQAHETAGQIVADAQRQADATREDARQRAQQVTLEAAAHIGAQQAAQAEREGKLAGETGSRLQELEDALGAAERQAEAVRSEYLRRRDGNAKYATGLLREAELEAADLRDRAWQAAERIEIRAAVEQERYAKRIEEARTRLAEAQQSVVAIADPAGRRLGRPQDRQPQHRQPQDREPQHREPQDRQPQQAAQARQSAPGQEAREPQPPAQAVPQQPQHRPPPVPPQPAQQPATGQPGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7ND04</accession>
    <name>A0A0F7ND04_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase/bleomycin resistance protein/dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_26900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018500.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_26900"/>
    <dbReference type="EnsemblBacteria" id="AKH85263">
        <property type="protein sequence ID" value="AKH85263"/>
        <property type="gene ID" value="AA958_26900"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_26900"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5658"/>
    <dbReference type="OrthoDB" id="1864858at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041581">
        <property type="entry name" value="Glyoxalase_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18029">
        <property type="entry name" value="Glyoxalase_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="125"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="238" mass="25685" checksum="ADA998F9AC4C59DF" modified="2015-07-22" version="1">MSLMVHGLDTTEAFYRGLFGWTFEEGPRTLGAYRLARLDGGQVAGIGAMAPERRLPVAWTPYLATDDADAAAELVRCCGGTVGVGPLDADAAGRKAICSDPAGAVFGVWQPRRPPEVERRARPGTPVWNDLLVPEPMMVAKFYELVFGYDVRSEGDTATLYVQDRPVASVCAAGEETLRETGPRWTTHFEVADVDASVARAVELGGRLVREPHETAAGRMAEVADIEGARFTLVHTPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDF2</accession>
    <name>A0A0F7NDF2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_23930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_23930"/>
    <dbReference type="EnsemblBacteria" id="AKH84752">
        <property type="protein sequence ID" value="AKH84752"/>
        <property type="gene ID" value="AA958_23930"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_23930"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5043"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH84752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="69" mass="7687" checksum="4B75088AED82A279" modified="2015-07-22" version="1">MADNRAFAVRPPAMPVLAVGAENSLGQTVSDQVRRYATDVRGEVVADSGHWIFEERPGEMTRLLLDFLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDG3</accession>
    <name>A0A0F7NDG3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Peptidylprolyl isomerase</fullName>
            <ecNumber evidence="2 4">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_03975</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2 4"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019763.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_03975"/>
    <dbReference type="EnsemblBacteria" id="AKH86535">
        <property type="protein sequence ID" value="AKH86535"/>
        <property type="gene ID" value="AA958_03975"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_03975"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.834"/>
    <dbReference type="OrthoDB" id="1861282at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="5">
        <location>
            <begin position="241"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH86535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="328" mass="33313" checksum="F7DFE348E75F5EB0" modified="2015-07-22" version="1">MGAALIVPALLFAAACGSEDSSDSDNGGKTGAVTKVTGAFGEEPKFDVPDDAKASDEAVVKVLGKGDGAKVGKGDQVRLDFAGKTMKGDQDLGSTWAQPAAGGGGGQQAGGAVHQQLMGKVGEPNQSLPPDVLDSVEGHTVGSRLLVEGTAGALVGESLNPESGIKKGDGLVWVIDVAGAGKVDAKAELKGESAEPREGMPEIEMPAGKAAKITIPDGADAPKELQEQVLIKGKGAKVEAGQGLVAQYTGYAWEDGKKFDSSWDNAGAATFQIGTGSVVAGWDKALVGKKVGDRVLLVIPPDLGYGKSKGHELEKKTLVFVVDILGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDH5</accession>
    <name>A0A0F7NDH5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Penicillin-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_24030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018024.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_24030"/>
    <dbReference type="EnsemblBacteria" id="AKH84772">
        <property type="protein sequence ID" value="AKH84772"/>
        <property type="gene ID" value="AA958_24030"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_24030"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5065"/>
    <dbReference type="OrthoDB" id="423699at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519428" evidence="1">
        <location>
            <begin position="24"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="2">
        <location>
            <begin position="155"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH84772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="484" mass="50809" checksum="FD3B85E3BD32D8E9" modified="2015-07-22" version="1">MIRNTRIAAACSLLLFLGLLVGAARVQVLNAPEYDANPANRRHALERYAQPRGDIYAAGRRLTGSEDTRQGLRYERSYTDGRLYAPVTGFASQLYGATLLEDTEDGVLAGTDGRLAPLPLWGDLTRSRRPGGQVHTTVVPAVQKAAFRGLRGRKGAVVALEPATGRVLALVSSPGYDPALLSGNSPATALAWDRLTGDPDQPLLNRAIRQTYPPGSTFKVITAVAALESGRVTDIDAPTRTPNPYRLIGSTTLLRNEASGCADAPLREAFAESCNTVFAKLGATVGTRRIVETAEAFGFNDGGLSLPSPVLPSHVDTRMDPAQVALSAIGQYDTRATPLQMARVAATVANGGRSMRPYLVDRLADAGGETVARTRPAYEETVMTPGTAALLRQMMIDAVSDGTGGPAAIDGLTVGGKTGTAQHGVDNSENPYAWFLSWAQRPGTAVPGVAVAVVVEDAEADRADINGGGSAAPVARGVMRAALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDJ1</accession>
    <name>A0A0F7NDJ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA polymerase sigma70 factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_05555</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019804.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86565">
        <property type="protein sequence ID" value="AKH86565"/>
        <property type="gene ID" value="AA958_05555"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_05555"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1164"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="5">
        <location>
            <begin position="15"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="6">
        <location>
            <begin position="117"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH86565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="187" mass="20296" checksum="07D988916C39F3F3" modified="2015-07-22" version="1">MIEESLDRPEAFAELYDRYAPAIHRYATRRLGAGAADDITADTFLAAFRARGRFDPARASARPWLYGIAANLIGRHRRAEVRGLRALARTGLDPVAHSWVDEADDRLIAQAAHAPLAGALAGLAAGDRHVLLLVAWADLSYAEVAEALEIPIGTVRSRLSRARRKVRAVLGTDPHSTYDTPEAATHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDQ8</accession>
    <name>A0A0F7NDQ8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH luxR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_24405</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018084.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH84832">
        <property type="protein sequence ID" value="AKH84832"/>
        <property type="gene ID" value="AA958_24405"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_24405"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5144"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="735"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="387"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="390"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH84832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="799" mass="86423" checksum="43169C29F230112C" modified="2015-07-22" version="1">MNAGAVVAAKEHEDAWGPEDLLTGRATSPAGYLGDTPTPLVGRTRDLDRLATVLSAPDAGLVTVTGPAGVGKSRLVMEYLRRFGPGPGGTVEVFDFGRITDPAMGALMLRRLKEQLHEGPAAVQSALEGLGPGPYTVLFDHYEDVADELAPLLTEFRRSCPQVRVVTVGTTRLGLYGERVVRLRPLPTGHGVEADLPAVSRIPAVELFVQYARAVRPEFKLTAENFRYVLALCRLVGGLPFAIELAAEQVKLAEPDLILERFERGTGDLRRIDQHPYSRHSSISTMVSWVFARLPAEERMLLNQLAIFEGPFTTRAAAGVLTGFDAAGYRTLERLIDASVLIPEERPDGELSLSIPSSVRHAAARSLALLPIHETLRKAHGEYFLALATPHPTPPEPGAPSAGPRAAPGPETRADLLAAFGYWREARDGRFMALIAGALRDQSTGAAQTRQCLRLTEEVLRAGVEDARLHARTLEAAGGLAMRLGSGAARGYLAQARDAYRAVRCDVGLVRCLGLLGDEAYAAGDLERARRRFEEGLAVLASPARAGVTGDTAIGVGRYLSRRLAVVARDAGNLARADELARTALAAELGREDFGGAVTARYVLASVRLLEQDSAEARALFADAAEQLGGLADAPEQPECLEMLAITLYKWRRITDWRLLTATLGLANLLRRRLGYPRPRPLTDLTTAILATASQELTADDYMWAWRSGADLTWEAALRLMPAADARPVAGDDVPTDVADILTKRELEVALLVAEGLTNRVIARRLGIAEWTVVNHLRKVMRKLGCQSRVQVTRRLAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NEJ7</accession>
    <name>A0A0F7NEJ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_18800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_18800"/>
    <dbReference type="EnsemblBacteria" id="AKH86880">
        <property type="protein sequence ID" value="AKH86880"/>
        <property type="gene ID" value="AA958_18800"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_18800"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3947"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH86880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="203" mass="22712" checksum="9C418D5DF5E73AC7" modified="2015-07-22" version="1">MTRRQCTGEYKIKPIKQKVRKLLGYPYPARIPKGVFVEQWVGISTDEFHRAKDADVQYMRNRHPLLDLEWTRADCTRYLTSLGFAGTPKSSCLGCPFHGNAQWRHIRDTSPDEWAGVVEFDAAIRNGNARANATGTHLLGEAFLHRSRMPLDQAPIDHVTAAERAAQRISTEEAEELENGVVDSCSPWACRGDAAQGDFDLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFV1</accession>
    <name>A0A0F7NFV1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_28995</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018845.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH85612">
        <property type="protein sequence ID" value="AKH85612"/>
        <property type="gene ID" value="AA958_28995"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_28995"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6109"/>
    <dbReference type="OrthoDB" id="2160446at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH85612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="626" mass="68456" checksum="EFFB182B9C2696DC" modified="2015-07-22" version="1">MRTRRAHRLAEQANATGNLRERHAWRMLTRAAEAGDPAAVDAVRTAWLRHPAGETWDLVREWVTFADLLTAATDPTRPAEQRAALGRFCAGQGFLPVGDVDRVLFYALTGQHAHHAALDPDGALLAVAYHGASKQTQQAVRDAMVGRGELNLVRALTDRPRRPLTAPEADYLTKQLADAREWAHLWRLIPTMPLANAARAAQLFTDWRPADDHARTFAGLLASVDPSALTTSNWPTTARIKRRLRENAIYFGDVRPYNTSFSPDGSELSIIHAKGITVYETHTGHTVADYLGRRLEKALALGEGMVVCKILRGDWVVGVPGRALAPLAPGEHVHGIRLSSTGFVATTPDHPRFASVDAEALIDAAERINWWGTVPIRELEIDQGTGIIDVADFDLLSGRLALRAYRKNSRGVLVLDGDLNPVAHWWDNYGAYGKADFYGPERVVRWTRYVGGATISTRRLTGDKYEQVACTKNARGSPVIVPTLEQLLIGRPDVSAPVWLDVDTLTETDGPPGFPAMDAHTIHVEFSPGDWVVAIASPDDIRIHDLGLRRVAALLDQPLSEARREDLDFVATQAQRAVPGPVAAAVDVLHACLAYRFGSDIVLGSRARIHLGAHDIALGNPGKDQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NGK2</accession>
    <name>A0A0F7NGK2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_05790</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019810.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86569">
        <property type="protein sequence ID" value="AKH86569"/>
        <property type="gene ID" value="AA958_05790"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_05790"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1212"/>
    <dbReference type="OrthoDB" id="1290978at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005330">
        <property type="entry name" value="MHYT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03707">
        <property type="entry name" value="MHYT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50924">
        <property type="entry name" value="MHYT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="MHYT" evidence="2">
        <location>
            <begin position="8"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH86569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="281" mass="28495" checksum="804968862AD6AC97" modified="2015-07-22" version="1">MPVDGFTHGLLTPATAFVMAAVGSALGLRCTMRALTVEPARRAGWLLLGAVAIGTGIFTMHFIAMMGFTADSVHINYDVPITLASLGVAIVVVGIGVFTVGYLGRTAFALTTGGIVTGLGVAAMHYLGMAGMKMDRGRLVYDGTVVALSVLIAVVAATAALWLSMTVKRFGVAVGAALIMGVAVSGMHYTGMAALEVHAHAATTVADGKSPAEILAPILIGPVLLLVFVGLFVGMDPLENEWRVSVADEGIVGGDAAAPEPAGSGAAAYFERGGGRRPGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NGN0</accession>
    <name>A0A0F7NGN0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_07600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019841.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86594">
        <property type="protein sequence ID" value="AKH86594"/>
        <property type="gene ID" value="AA958_07600"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_07600"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1594"/>
    <dbReference type="OrthoDB" id="2040681at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="154"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH86594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="292" mass="31041" checksum="2B76D0E19CAF0635" modified="2015-07-22" version="1">MSRPVIVGVDGSPEAVAAAGWAARESALRGVDLRIVYADEWPDAETIQHSSPGARRRWAEELLDEAAEAGRREHPALEIETRHLSGRPAGVLADEAAEAGLLVLGSRGLGGVRGFLLGSVGMATISVTERPVVLVRAPGGPYTPERAAPAGPTRDVVVGVDIDQGFAPLLDFAFQEAAPRGDRVVVLYGWSIRPVVRDASALVAAEREVSPDIVWRLAEALRPWRRKFPSVEVAERSPIGSPAQLLLHATGNADLVVVGRRARRGPWGAHIGSVTHAVIHHCPVPVAVIAHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NGS0</accession>
    <name>A0A0F7NGS0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cysteine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_01830</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019715.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_01830"/>
    <dbReference type="EnsemblBacteria" id="AKH86493">
        <property type="protein sequence ID" value="AKH86493"/>
        <property type="gene ID" value="AA958_01830"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_01830"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.398"/>
    <dbReference type="OrthoDB" id="1677960at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901607">
        <property type="term" value="P:alpha-amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PALP" evidence="4">
        <location>
            <begin position="54"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH86493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="380" mass="41305" checksum="B056058A6EFC2983" modified="2015-07-22" version="1">MTASAQPPAAAPGGALPTLDVDRSDPAARAWLKEAVRKVQADANRTADTHLLRFPLPESWGIDLYLKDESTHPTGSLKHRLARSLFLYGLCNGWIRPGKPVIEASSGSTAVSEAYFADLIGVPFIAVMPRTTSSEKARLIEFHGGTCHLVDDPRTVYEVSARLAEETGGHYMDQFTYAERATDWRGNNNIAESIYTQLRLERFPEPAWIVATAGTGGTSATIARYVRYLQYDTRVCVADPENSCFFAGWESGDPGVTVDRGSRIEGIGRPRMEPSFLPAAIDRMMKVPDAATVAAVRALERAIGRRAGGSTGTGLWSALRIVGEMVAAGRNGSVVTLICDPGDRYLDKYYSDDWLAEQGLDIGPYAAHLDAFLATGRWSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NGV4</accession>
    <name>A0A0F7NGV4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GHL10 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_03675</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019755.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_03675"/>
    <dbReference type="EnsemblBacteria" id="AKH86528">
        <property type="protein sequence ID" value="AKH86528"/>
        <property type="gene ID" value="AA958_03675"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_03675"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.773"/>
    <dbReference type="OrthoDB" id="1573900at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003790">
        <property type="entry name" value="GHL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02638">
        <property type="entry name" value="GHL10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="GHL10" evidence="2">
        <location>
            <begin position="31"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH86528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="404" mass="45435" checksum="63A79F9899385506" modified="2015-07-22" version="1">MGALSAVTVAGDAIASPAGAAGRAHGRPAGQMRGSWVATVANIDWPDQQGLSAAEQQRQLLARLDEAADRRMNTVVFQARPTADAMWPSPYEPWSEWLSGTQGADPGWDPLGFAVREAHRRGLELHAWFNPYRVRNDALAEKLVPDHPANRHPEWVVPYGGKIYYDPGVPEVRRFVQRCILDAVRRYDIDAVHFDDYFYPYPVAGQEFADEETYRRYGGAFADKADWRRNNVDLLVAELGRAIKRTKRTVQFGVSPFAVWRNAATDPEGSDTQAGTQTYDNLYADTRTWVRERWIDYIVPQVYWNIGFAVADYAKIVPWWNDVVAGTGVNLYIGEALYKVGAAGQPAAWFDPAELSRHLTFCQDYPEVQGNMYFSAKLLPQDPLGAVSRLVADHYREPARPPRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NGY9</accession>
    <name>A0A0F7NGY9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">S-adenosyl methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_31520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019225.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_31520"/>
    <dbReference type="EnsemblBacteria" id="AKH85997">
        <property type="protein sequence ID" value="AKH85997"/>
        <property type="gene ID" value="AA958_31520"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_31520"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6658"/>
    <dbReference type="OrthoDB" id="1139523at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006764">
        <property type="entry name" value="SAM_dep_MeTrfase_SAV2177_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04672">
        <property type="entry name" value="Methyltransf_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017393">
        <property type="entry name" value="MTase_SAV2177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="269" mass="29549" checksum="F91A4F5A637BB734" modified="2015-07-22" version="1">MAEGQSTPAEGALAKIDTTVPHSARIWNYWMGGKDNYAVDRQAGDEYRQIAPNIETMARASRDYLIRTVTHVAGEAGIRQFLDIGTGLPTYDNTHQVAQRLAPGSRIVYVDNDPLVLRHAQALLTSTREGVTTYVDADLHKPEAILEEAGKTLDFSQPMALMLMGVLGHVQDYEEAKSIVRRLQAALPSGSYFVHYDSTATDKALQEAQQGYDDTGAIPYVLRTPDEISAYYDGLELIEPGMVSCPLWRPEPGTDPEPTDVYGGVAHKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NHX1</accession>
    <name>A0A0F7NHX1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_18620</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aromatic prenyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86873">
        <property type="protein sequence ID" value="AKH86873"/>
        <property type="gene ID" value="AA958_18620"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_18620"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3905"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd13931">
        <property type="entry name" value="PT-CloQ_NphB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033964">
        <property type="entry name" value="Aro_prenylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020965">
        <property type="entry name" value="Prenyltransferase_CloQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036239">
        <property type="entry name" value="PrenylTrfase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11468">
        <property type="entry name" value="PTase_Orf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00036">
        <property type="entry name" value="Aromatic_Prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01163">
        <property type="entry name" value="II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143492">
        <property type="entry name" value="SSF143492"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH86873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="291" mass="31838" checksum="1476E4510B50C736" modified="2015-07-22" version="1">MEEAAGLLGVPVAREKVRPVLTAYQDALADAVVVFSMAGGRRATELDFSISVPTDHGDPFTTALQRGLTEKTGHPVDNLLAELREGFPLGMYAIDGMVSTGFKKTYASFPTNEPQPLDDLLDVPSMPASARANAKLFANYGLDKVQMVSVDYPKRQVNLYFSELNTDYLQPAQVKALAAEMGLIEPSELGLEFAKGSFAVYPTLSYDTDASDRLCLAVISSDPTLAPTTSEPEVTQFSTYANNAPYAYAGENRTLVYGLTLTPKEEYYKLGSYYQITDYQRKLVKAFEALD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NHZ6</accession>
    <name>A0A0F7NHZ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Mannitol ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_33600</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019569.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_33600"/>
    <dbReference type="EnsemblBacteria" id="AKH86347">
        <property type="protein sequence ID" value="AKH86347"/>
        <property type="gene ID" value="AA958_33600"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_33600"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.7095"/>
    <dbReference type="OrthoDB" id="1510342at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="162"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="206"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="262"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="94"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH86347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="298" mass="31548" checksum="0B59CA8B8189757D" modified="2015-07-22" version="1">MTTTVATAEKPARTGRAALPPALRKARRRSAGLGLLAWLVGIAFFLPVAWMVLTSLHAETDAAANPPAVAASLTLDGYRTFFGSGGGPSPWPALLNSLMASVFSTVLVLALALPAAYALSIRRVQRWTDVLFFFLSTKMLPVVAGLLPIYLFAKNTGMLDNIWLLVLLYTSMNLPIAVWMLQSFLADIPVSIVEAAQIDGAKLTTVLTRVIAPVAGPGIAATSLICFIFSWNEMLFARVLTGVTAETAPVFLTRFITSQGLFLAQVCAASVVISLPVLAAGFAAQDKLVQGLSLGAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NI71</accession>
    <name>A0A0F7NI71_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_30620</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_30620"/>
    <dbReference type="EnsemblBacteria" id="AKH87149">
        <property type="protein sequence ID" value="AKH87149"/>
        <property type="gene ID" value="AA958_30620"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_30620"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6471"/>
    <dbReference type="OrthoDB" id="626204at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="171"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="273"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="310"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="339"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="366"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="411"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="464"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="21"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH87149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="501" mass="50753" checksum="AE5792B5D98A467F" modified="2015-07-22" version="1">MAMDVQRTSPPTAPGARAWLGLLVVLGPVLLVAMDGSVLFLAMAAISAELSPSADQALWILDGYGFAVGSLLIAFGGIGDRYGRLRLLLTGAAVFGAASAGAAFAPSAELLIAFRVLMGVAGATLLPSALAVLSELFADARRRAQAIGIFAAAFAAGFAIGPVVGGQLLAHFWWGSVFLINLPVVALFLLLAPRLLREVRAGGQGRVDVPSVALSAAGILLAVYGIKRAAAHGPAAVPLVAAGAGVVLLWWFVRRQLRLALPLIDLRLFRDRVFAIAAVTGLLPLAAWSAVAYLGGIYLQSVRGLGVFDAALVTLPGALVLTVTCVVTPAVVARTGTRAALLACHFVIAGGLLLLLPTGVSGGTGWYVAATVVAGVGYGISFSVVADTAVAAVPPERAGSAGAIAETSNELGNALGIALLGSLAALVFRLRGPDLAGTLTETLQAPGITAAAAGQAESAFVTGLHAAALAAALLHAALGLFTLRHLPRRRHPAPPLPASLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NIF6</accession>
    <name>A0A0F7NIF6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ATP-dependent helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_26625</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020428.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_26625"/>
    <dbReference type="EnsemblBacteria" id="AKH87048">
        <property type="protein sequence ID" value="AKH87048"/>
        <property type="gene ID" value="AA958_26625"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_26625"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5602"/>
    <dbReference type="OrthoDB" id="679382at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="PTHR11472"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="6"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH87048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="658" mass="70332" checksum="3D209332095A0E76" modified="2015-07-22" version="1">MRELLHAAVAAVGGVEREGQVAMAEAVAEAIADGSHLLAQAGTGTGKSLGYLVPALAHGERVVIATATLALQRQLVERDLPRTVEALHPRLRRRPEFATLKGRSNYLCLHRVHEGVPQDDPDLGAGLFDPFESASSQPSSKLGQDLLRLRDWADETESGDRDSLTPGVSDRAWSQVSVSARECLGAARCAYGPECFAEAARERAKLAEVVVTNHALLAIDALEGAPVLPPHEVLIVDEAHELVSRVTGVATGELTPGRVNRAVRLSAKLVNEKAADALQTAAESFERLMELALPGRLEPVPEDLGYALLALRDASRTVISALGTTRDSSVQDEDVVRRLALASVENVQEVAERITQGSEFDVVWFERHDRFGASLRVAPLSVSGLVREKVFSDRSVTLTSATLKLGGDFAGIGASLGLPPEGSSEEGAPVWKGLDVGSPFEYRKQGILYVARHLERPGRDGTRKDMLDELAELVEAAGGRTLGLFSSKRAAEAAATELRGRLDVPVLLQGEETLGELIKRFAADEATCLFGSLSLWQGVDVPGAGCQLVVMDRIPFPRPDDPLATARQEAVEKAGGNGFMAVAATHAALLMAQGAGRLVRATGDRGVVAVLDPRLATARYGSYLRASMPDFWYTTDRNQVRRSLAAIDASARADRSNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NJ12</accession>
    <name>A0A0F7NJ12_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Integrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_15340</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_15340"/>
    <dbReference type="EnsemblBacteria" id="AKH86792">
        <property type="protein sequence ID" value="AKH86792"/>
        <property type="gene ID" value="AA958_15340"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_15340"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3227"/>
    <dbReference type="OrthoDB" id="785253at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14659">
        <property type="entry name" value="Phage_int_SAM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="5">
        <location>
            <begin position="66"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="4">
        <location>
            <begin position="198"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH86792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="408" mass="45761" checksum="C1B71C17E4E40549" modified="2015-07-22" version="1">MSGKRANGEGSIYPYKNGYAAYVWVTKPDGKRARKYVYSKTRALVHEKWLKAHADAKKGPVATRHRTVAAFLDYWLESIVKPSLAPLSYVSYEGYVRLYIAPHLGGKRLDKLTVRDVREWLTKLATICQCCAQDKDARRKPSRRRCCAIGECCESYPSRRVIQASRDALRAALTHAVAEEEIGKNVASLVKVPKPRRRRIKPWSVAEAGRFLTDAAARDDHLFAAWVLVLCLGLRRGEVLGLTWKSVDLDTGELYVDHQIQRAGRLILHRETKTEDSDDFLPLPALCVKALRMRHAQQTGDRKAAGELWQDSHGLIFTTKYGTPIEPGNLTRMFALRARRAGLRVIPLRNTRHTCSSLLVALKVHPKVAQRILRHSQIAMTMEVYAEASDEAVRAAIGQLSDAMGGTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NJ55</accession>
    <name>A0A0F7NJ55_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_16970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_16970"/>
    <dbReference type="EnsemblBacteria" id="AKH86832">
        <property type="protein sequence ID" value="AKH86832"/>
        <property type="gene ID" value="AA958_16970"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_16970"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3570"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH86832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="449" mass="49020" checksum="272BF395801EFE36" modified="2015-07-22" version="1">MRESGLTPTSLAGQVRELGRRRGLELRCTHTYVKRWLRGSFGSSVPPELIAAVFSRRLGRDITPRDLAAPPPTGYATAGGAASLARRRLPPDDLGLRGPSTPLGAVRTAAQLWDADPRYALPPVSATDLRDSVRRWRRATPPAPPQRAIGSYRVGQPDIAKIHALTEHLAMLDNRYGGGAARSIAMTHLRTDVLPMLEGSYSGTVGRNLFRAAALVTHHTGHLLYDTGGHGAARRYLRLALDMAYHGHDRAFAAKILGTLAHQAVHLGDYREAVELAEAGLAEPGLTPAGRAVLHAMAARAHARLRDSRATAISLSHAESALSAGTPAQEPVWLRYFSGAELHDEIAHCLVDLRQARAARPHAEHGIAARTDRYARSIAFTRVVLATAWLQQREVERACQVATGALRATEDIQSERVRGYLAGFRERLRPFRNVPAARDFSYKAARMLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NK73</accession>
    <name>A0A0F7NK73_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Crystallin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_33270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020651.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_33270"/>
    <dbReference type="EnsemblBacteria" id="AKH87207">
        <property type="protein sequence ID" value="AKH87207"/>
        <property type="gene ID" value="AA958_33270"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_33270"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.7027"/>
    <dbReference type="OrthoDB" id="1661477at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4080.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005502">
        <property type="entry name" value="Ribosyl_crysJ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036705">
        <property type="entry name" value="Ribosyl_crysJ1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03747">
        <property type="entry name" value="ADP_ribosyl_GH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101478">
        <property type="entry name" value="SSF101478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="465"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH87207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="495" mass="51561" checksum="E10CD93C15EEFC30" modified="2015-07-22" version="1">MHGAPLRLTWVQPEDLVGHELRQAAEDGRAAGPLLRRWLGAGGHQAPARAGASPGPPKPRLRALALELLDELAALETPLAAVEPTDLDEIRAACPRWPARVPAPGPDTDGAYGDRLCTRLHAAWLGRAAGCVLGKPVEKVTLEGIRAIARSTGNWPVHTWFTAEGLDPAVAAAHPWNRRSAATSLAETLDGAPEDDDLNYPLLALLLLDRHGHAFTTADVGQLWLDELPAGRTFTAERVAYRNLLDGVEPPHTGAYRNPFREWIGAQIRADVHGWTHPGDPAGAAAAAHRDAVLTHTANGVYGAMFAAAALAAAAGGGTDVDEVLRTGLAVVPPRSRLARAVRHGIELARSEPTGTPEGFEAVVDDLHAAHEGRHWVHVVPNAALLAAALTHSGGDFTGAVCRVVSGGWDTDSNGATAGSVAGLLAGSPAALPERWTAPLRNRLATTVGGMDGIGFDELAARTAAHALPPPAPDDAAAAAGTGPVPPHEPRRPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-10-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MZ32</accession>
    <name>A0A0F7MZ32_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_04305</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH81540">
        <property type="protein sequence ID" value="AKH81540"/>
        <property type="gene ID" value="AA958_04305"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_04305"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH81540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="71" mass="7313" checksum="65FEC57DB8CDE7F0" modified="2015-07-22" version="1">MPLNFFSIEGPSAPSSACSAFWAVVSAPSDSPFPITPSSYGSTAFSSRPFHFPGTVSPSTVTAGSHAMAMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MZ90</accession>
    <name>A0A0F7MZ90_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">N(G),N(G)-dimethylarginine dimethylaminohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_04705</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DDAH family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014965.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_04705"/>
    <dbReference type="EnsemblBacteria" id="AKH81610">
        <property type="protein sequence ID" value="AKH81610"/>
        <property type="gene ID" value="AA958_04705"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_04705"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.992"/>
    <dbReference type="OrthoDB" id="592329at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033199">
        <property type="entry name" value="DDAH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12737">
        <property type="entry name" value="PTHR12737"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR633199-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH81610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="258" mass="27472" checksum="966CD864827FF211" modified="2015-07-22" version="1">MRSRKALVRRPGPRLAEGLVTHIDRTPVDADRALAQWRSYVAALELHGWETVEVEPADDCPDAVFVEDTVVMYKNVALVTRPGADSRKPETPGVEAAVSLMRCSVNRVHAPGTLDGGDVLKVGDTLYVGLGGRTNTDGIRQLRACFEPLGARVVTVPVTKVLHLKSGITALPDGTFATHAGLIDTPELFPGRIEVPEAAGAHVILLGGGALLMAASAPQTAALYEELGYTPVPVDISEFEKLEGSVTCLSVRMRGLYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MZP2</accession>
    <name>A0A0F7MZP2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UvrABC system protein C</fullName>
            <shortName evidence="6">Protein UvrC</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Excinuclease ABC subunit C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">uvrC</name>
        <name evidence="11" type="ORF">AA958_05720</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Interacts with UvrB in an incision complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the UvrC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015133.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_05720"/>
    <dbReference type="EnsemblBacteria" id="AKH81780">
        <property type="protein sequence ID" value="AKH81780"/>
        <property type="gene ID" value="AA958_05720"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_05720"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1197"/>
    <dbReference type="OrthoDB" id="1036075at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009380">
        <property type="term" value="C:excinuclease repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009381">
        <property type="term" value="F:excinuclease ABC activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00203">
        <property type="entry name" value="UvrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000305">
        <property type="entry name" value="GIY-YIG_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035901">
        <property type="entry name" value="GIY-YIG_endonuc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001943">
        <property type="entry name" value="UVR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036876">
        <property type="entry name" value="UVR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004791">
        <property type="entry name" value="UvrC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001162">
        <property type="entry name" value="UvrC_RNase_H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038476">
        <property type="entry name" value="UvrC_RNase_H_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01541">
        <property type="entry name" value="GIY-YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08459">
        <property type="entry name" value="UvrC_HhH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00465">
        <property type="entry name" value="GIYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46600">
        <property type="entry name" value="SSF46600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82771">
        <property type="entry name" value="SSF82771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00194">
        <property type="entry name" value="uvrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50164">
        <property type="entry name" value="GIY_YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50165">
        <property type="entry name" value="UVRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3 6" id="KW-0228">DNA excision</keyword>
    <keyword evidence="5 6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 6" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="GIY-YIG" evidence="9">
        <location>
            <begin position="16"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="UVR" evidence="8">
        <location>
            <begin position="208"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="UVRC" evidence="10">
        <location>
            <begin position="259"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="467"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="467"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AKH81780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="677" mass="74955" checksum="D39606D0E61EBCBD" modified="2015-07-22" version="1">MADPSSYRPKPGQIPDSPGVYRFRDEHGRVIYVGKAKSLRQRLSSYFQDLAGLHQRTRTMVTTAASVEWTVVATEVEALQLEYTWIKQYDPRFNVKYRDDKSYPSLAVTLSEEYPRVQVMRGPKRKGVRYFGPYAHAWAIRETVDLMLRAFPVRTCSAGVFKRSAQIGRPCLLGYIGKCSAPCVGRVTAAEHRELAEEFCDFMAGRTGAYLKRLERQMHEAAEEMEYEKAARLRDDIGALRSAMEKNAVVLADATDADLIALAEDELEAAVQIFHVRGGRVRGQRGWVTDRVEAVDTAGLVEHALQQLYGDEQAEAIPREVLVPALPRPAGPVREWLAERRGARVDLRVPQRGDKKDLLATVARNAQQALALHKTKRASDLTTRSRALEEIAEALELDSAPLRIECYDISHLQGDDVVGSMVVFEDGLARKSEYRRFEIKGFTGQDDVRAMHEVITRRFRRYVQEKQKTGEWGDPEAEAAAERGRAGAAGATAGADAAAEVPAGRDPDTGRPRKFAYPPQLVVVDGGQPQVAAAKRALGELGVDDVAVVGLAKRLEEVWLPDSDDPVILPRSSEGLYMLQRVRDEAHRFAIAYQRKKRAKSMKAGPLDDVPGLGESRRRALLRHFGSVKRLRAATIDQICEVPGIGRKTAENIAATLAQAAPAAPAVNTATGEIMDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N024</accession>
    <name>A0A0F7N024_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AP_endonuc_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_02960</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014669.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_02960"/>
    <dbReference type="EnsemblBacteria" id="AKH81306">
        <property type="protein sequence ID" value="AKH81306"/>
        <property type="gene ID" value="AA958_02960"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_02960"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.632"/>
    <dbReference type="OrthoDB" id="1194699at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519000" description="AP_endonuc_2 domain-containing protein" evidence="1">
        <location>
            <begin position="35"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="AP_endonuc_2" evidence="2">
        <location>
            <begin position="66"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH81306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="317" mass="34684" checksum="D5AED2128D215601" modified="2015-07-22" version="1">MSKSSLHRRGFLRAAAGTAAVAAGAGAFASPAAAGHGGLIPRGRIGLQLYSVRDQIQQRGFTPVLTELAAIGYKHIEFAGYTSPAEPDMTVPKLRKLLDDNGLCAGGAHLGLDALLNASTREREFENAAALGMDYVGTASDFPGRTAAEIQAGADRFNESGEVARGYGLKIYQHNHTNEFGPVTDRPGERRHDLFLSGTDPRYVFLELDILWAFGASVRFRDQLGEFDPLDYVNAAPQRYIAFHVKDGVRDPALTNQYRDVVFGQGELDFRRFFSGLRAPGLPLYFWEQDRAPQEPQGSIWAAEASYDAMVALRSRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0K8</accession>
    <name>A0A0F7N0K8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_07910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015520.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_07910"/>
    <dbReference type="EnsemblBacteria" id="AKH82170">
        <property type="protein sequence ID" value="AKH82170"/>
        <property type="gene ID" value="AA958_07910"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_07910"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1665"/>
    <dbReference type="OrthoDB" id="1060221at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="19"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="295" mass="32552" checksum="B0F83D1C03980BAA" modified="2015-07-22" version="1">MAERATGSTVPRRQLGRYLRDLRNQARLTVRSAAHRLEWSEAKMWRIETGQSSLRSFDVETMCKVYGAPADITEALMGLAKETKAKGWWHAYGDVIPEGFDVYIGLQEAASSLTSYQSDLVPGLLQTEGYARAVIRHHNPDETEAEIDRRVRLRIERQSLLTRATAPPSLRLVLNEAVLARPVGGPEVMAGQLTYLAEAAERSNIAIRVAPFATGLHLGMLSGSFVVLRFPVNGDGTETEPPTVYSDGFTGSLYLDKASEVQSYQEVFDDVWESSPDEQVSQRLIADTAGSHGQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0L8</accession>
    <name>A0A0F7N0L8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF2263 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_00840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH80953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_00840"/>
    <dbReference type="EnsemblBacteria" id="AKH80953">
        <property type="protein sequence ID" value="AKH80953"/>
        <property type="gene ID" value="AA958_00840"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_00840"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.188"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012664">
        <property type="entry name" value="CHP02452"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019261">
        <property type="entry name" value="PARG_cat_microbial"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10021">
        <property type="entry name" value="DUF2263"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF014899">
        <property type="entry name" value="UCP014899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02452">
        <property type="entry name" value="TIGR02452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2263" evidence="2">
        <location>
            <begin position="45"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH80953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="332" mass="34849" checksum="B835DCFD7825602A" modified="2015-07-22" version="1">MVAARPRCVPSWHDEDSGPRRPGGLRHGTDRPRRCPVSARLREVARDNERILAAGGYEAAGRWVPLGEAAARAADGTRMHGPGPVEGAGGAPAGGPRDTPAEVTAETSLAAARRLAGEGADRVGVLNFSSARNPGGGYVNGARAQEEELCRASALYPALLRAPEFYAAHRADRSPFYTHRVIHSPAVPVFRDDAGALLPEPYAVDFLTSPAPNAGVIAQRTPEETDRIPAALAGRAERVLEVAAVAGVTALVLGAWGCGVFRNDPAQVAAAFRTHLEPGGRFAGRFPRLVFAVWDRQPRSANRAARSGSTAISATGSPSSPCRTPSGSPARW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0Z4</accession>
    <name>A0A0F7N0Z4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LacI family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_01390</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014404.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_01390"/>
    <dbReference type="EnsemblBacteria" id="AKH81039">
        <property type="protein sequence ID" value="AKH81039"/>
        <property type="gene ID" value="AA958_01390"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_01390"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.307"/>
    <dbReference type="OrthoDB" id="1796334at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001761">
        <property type="entry name" value="Peripla_BP/Lac1_sug-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00532">
        <property type="entry name" value="Peripla_BP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH81039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="331" mass="35575" checksum="0DAF6A6D64383FCE" modified="2015-07-22" version="1">MRDVAEHASVSPMTVSRVLHDDPGVSKATRARVLAAVDSLGYRRNEVARNLRLGRTSGLIGLVVTNLANPFYSQFALGVESGVSRQGLKVVLTNTDEDVERERRLVEELTARRVDGMIVVPAGNDHSHLAAQPGSVPIVLGARPPSGVPLDCVLVDDFGGAREATAGLLAAGHTRLGFLGLPPSVWTSSERFRGFCVALEEAGVALDERYVRLRQRTIPAAEAAARELLELPRPPTALFCANSRNTLGAFRATSRLGRPVSLAGFDDFELADVLGVPLIVAYDPRELGRRAAELLLRRMNESDADPDDAAPLRIVVPTKVVRYGDPGSGQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0Z7</accession>
    <name>A0A0F7N0Z7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zn-dependent hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_08650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015638.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_08650"/>
    <dbReference type="EnsemblBacteria" id="AKH82290">
        <property type="protein sequence ID" value="AKH82290"/>
        <property type="gene ID" value="AA958_08650"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_08650"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1824"/>
    <dbReference type="OrthoDB" id="1581636at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="25"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="205" mass="21248" checksum="AF3A97954E17CBC2" modified="2015-07-22" version="1">MSRARIDHLVTSGTFSLDGGTWDVDNNVWIVGDDTEALVIDAAHDSDAIAAAVGDRRVTAIVCTHAHDDHIDAAPALAARTGAPVLLHPDDRVLWEMTHPDRAPDAALADGQTLAVAGTELTVLHTPGHAPGAVCLYGPELGTVFTGDTLFHGGPGATGRSYSDRPTIEASIRARLLTLPPETVVRTGHGESTTIAAEAAGAGSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N1E5</accession>
    <name>A0A0F7N1E5_9ACTN</name>
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        <submittedName>
            <fullName evidence="2">Dynein regulation protein LC7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_02370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_02370"/>
    <dbReference type="EnsemblBacteria" id="AKH81209">
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        <property type="gene ID" value="AA958_02370"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_02370"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.508"/>
    <dbReference type="OrthoDB" id="1602136at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004942">
        <property type="entry name" value="Roadblock/LAMTOR2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03259">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00960">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Robl_LC7" evidence="1">
        <location>
            <begin position="16"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="145" mass="15198" checksum="FD461C42395A864E" modified="2015-07-22" version="1">MIEPGTVHTQRSGGLDWLLDDLVRRVADVRHAVVLSGDGLAVGNSRTLSREDAEHLAAVASGFHSLAKGAGRHFRAGGVRQTMVEMDDGFLFVAAAGDGSCLAVFSAATADMGLVAYEMARLVARVGEHLYTAPRTAAAKPRNPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N1V6</accession>
    <name>A0A0F7N1V6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA polymerase III subunit epsilon</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_03385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_03385"/>
    <dbReference type="EnsemblBacteria" id="AKH81384">
        <property type="protein sequence ID" value="AKH81384"/>
        <property type="gene ID" value="AA958_03385"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_03385"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.719"/>
    <dbReference type="OrthoDB" id="1985371at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
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        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="1">
        <location>
            <begin position="8"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="242" mass="26282" checksum="80E23FA67A6C9F8F" modified="2015-07-22" version="1">MTLWYEGPLAAFDTETTGVDVERDRILSAAVVVQPHITSPPRCTSWLVSPDVEIPAAATAVHGLTLAHLQRLGRWPAPVMEEVGKALAAQCASHVPLVVMNAPFDLTLLDRELRRHRASSLPKYLGGAPLCVLDPLVLDRHLDRYRKGSRTLTALCEHYGVELAGAHEAGADATAALRLVRAIGQRYADRLGELTAPELHERQAAWHGAQARGLTAWFARTGSDERCDPAWPLRTSGLATVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N1V8</accession>
    <name>A0A0F7N1V8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Long-chain fatty acid--CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_06755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_06755"/>
    <dbReference type="EnsemblBacteria" id="AKH81961">
        <property type="protein sequence ID" value="AKH81961"/>
        <property type="gene ID" value="AA958_06755"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_06755"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1411"/>
    <dbReference type="OrthoDB" id="164380at2"/>
    <dbReference type="Proteomes" id="UP000034283">
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
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        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="23"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="606" mass="64224" checksum="6F1580047EB44A90" modified="2015-07-22" version="1">MREFALPALYEVPADANLSDLVRTNAARTPDLAVVARKTAAGDWRDVSAADFLAEVEAVARGLVAAGLRPGDRIGLMSRTRYEWTLLDFAIWTAGGVTVPVYETSSAEQIHWILSDSGAVACVVETAEHAAAVESVRGRVPLLRQVWQIEGGSGGEGDGKGAVAELTAAGTGVSDATLEEHRSAAGADSPATLVYTSGTTGRPKGCVLTHGHFLAECGNAVEQLRPLFRSGDSSILLFLPLAHVFGRLVEIAAMVAPMKLGHVSDVKNLTGDLAAFKPTLLLGVPRVFEKVYNSARAKAGADGKGKIFDKAAHTAIAYSRALDTGGPALGLRLRHALFDKLVYAKLRAVLGGRATHAISGGAPLGERLGHFYRGIGFTVLEGYGLTETAAAITVNLVQRPKIGTVGQPLPGCTIRIADDGEVLVRGGNVFEEYWADEDATAAALDGEWLRTGDLGSLDEDGYLSITGRKKEILVTAAGKNVAPAVIEDRIRAHALVAECMVVGDARPFVAALITLDEEFLARWAEEHGKQGRTAAELADDAELLAAVQLAVDDGNAQVSRAESVRRFRILPGQFTEESGHLTPSLKLKRGAVAKDFTEEIEALYER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2E1</accession>
    <name>A0A0F7N2E1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF1524 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_11785</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016136.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_11785"/>
    <dbReference type="EnsemblBacteria" id="AKH82800">
        <property type="protein sequence ID" value="AKH82800"/>
        <property type="gene ID" value="AA958_11785"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_11785"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2477"/>
    <dbReference type="OrthoDB" id="1510738at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011089">
        <property type="entry name" value="DUF1524"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07510">
        <property type="entry name" value="DUF1524"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519047" description="DUF1524 domain-containing protein" evidence="2">
        <location>
            <begin position="27"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1524" evidence="3">
        <location>
            <begin position="129"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH82800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="270" mass="28273" checksum="2B46B81871808BBC" modified="2015-07-22" version="1">MIRIRRLLPPLLAAASAVTVTFTAGCDTAEDRVDKPPADNAPASPGSPGGSGSPGAPGRGTSPLDNPDGTAPGLAPLTSAADREAALGVIGRLATESRGSGSGYDRDEFGYAWMDTATGVPLAGNGCDTRNDLLRRDGRDVRMESGDDCVVAAMELADPYAGKDIAFERGPSTSMDVQIDHVVPLSYAWQMGAATWAEEKREQLANDPLNLLAVDGDTNSSKGDSGPEEWLPPAEGIRCAYGVRFAQVAFKYEMPVTAADKETLRQQCGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2F1</accession>
    <name>A0A0F7N2F1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nitroreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_04420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014913.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_04420"/>
    <dbReference type="EnsemblBacteria" id="AKH81558">
        <property type="protein sequence ID" value="AKH81558"/>
        <property type="gene ID" value="AA958_04420"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_04420"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.931"/>
    <dbReference type="OrthoDB" id="1079953at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="1">
        <location>
            <begin position="124"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="329" mass="35539" checksum="7A06BD58F9A98879" modified="2015-07-22" version="1">MAARALDATGAAELVHAATAAPSMHNAQPWHFRCHLGHRTVEMRADMERAMPAADPERRSLHVGCGAALCNLRAAAAAAGWRTRTELLPAEHEPLLLASVRLTGAEPGEETDAALAALAEQIPRRHSSRWPFAERPVPPADLADLVEAARTEGAKLVFPDAWHAASLLELVQDAEVRDAETPDRAEELARWTHPWPDTADEGVPGYAYGPRRRGGTAPMRDFAGRTEPPGRTSAPFESVPNIALLGTAHDSPAEWLRAGQALERVLLTATRAGLAVSLTSEALEWSDLRALVRDPLTDVGQVQMVLRIGYGPRGPTTPRRPLSEVMEVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2J7</accession>
    <name>A0A0F7N2J7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">IclR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_08260</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_08260"/>
    <dbReference type="EnsemblBacteria" id="AKH82226">
        <property type="protein sequence ID" value="AKH82226"/>
        <property type="gene ID" value="AA958_08260"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_08260"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1742"/>
    <dbReference type="OrthoDB" id="370329at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
            <begin position="5"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="4">
        <location>
            <begin position="69"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH82226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="261" mass="28314" checksum="356CBA2C60BBCA05" modified="2015-07-22" version="1">MGRLVPAVTRALDILELFLDRDTTLSAPEITRKLGLPRTTVHELVTTLAARSYLGAVPGQPGRYRLGVRTYQLGSTFGEQLDLAAEGREVAREVAETCDETVHIAILEDTDVIYIAKVDSTRAVRMVSATGRRLPAHCTAVGKMLLASLPEQALDARLPESRPLVAMTDRSLTSVRDLRRHLAGVRERGIAVEERESNPDVSCVAAPVHDSAGRVVAALSISVPMIRWSGERRDELAELAAKGASRLSERLGHRGGRAGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2L1</accession>
    <name>A0A0F7N2L1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DSBA oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_04790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014979.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_04790"/>
    <dbReference type="EnsemblBacteria" id="AKH81624">
        <property type="protein sequence ID" value="AKH81624"/>
        <property type="gene ID" value="AA958_04790"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_04790"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1009"/>
    <dbReference type="OrthoDB" id="996965at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001853">
        <property type="entry name" value="DSBA-like_thioredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01323">
        <property type="entry name" value="DSBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DSBA" evidence="1">
        <location>
            <begin position="10"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="206" mass="23014" checksum="1A2FA3620E7EA228" modified="2015-07-22" version="1">MAAAAGEKPKVDFYFDPACPFAWITSRWIIEVERQRDIDLRFRVMSLSVLNEGRDLPEWYRELLDKAWGPVRVCIAAAQQHGEDVLRDLYTALGTRIHNGGEKDYETVVKDALAEVGLPAELAEAAESDKYDEALRKSHHEGMDPVGEDVGTPTIHIDGVAFFGPVMTAIPRGEEAVRIFDGAVAMASFPNFFELKRTRTGDLNFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2Q6</accession>
    <name>A0A0F7N2Q6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">DNA repair protein RecN</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 7">Recombination protein N</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AA958_04970</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">May be involved in recombinational repair of damaged DNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the RecN family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015008.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_04970"/>
    <dbReference type="EnsemblBacteria" id="AKH81653">
        <property type="protein sequence ID" value="AKH81653"/>
        <property type="gene ID" value="AA958_04970"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_04970"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1045"/>
    <dbReference type="OrthoDB" id="1074831at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004604">
        <property type="entry name" value="DNA_recomb/repair_RecN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11059">
        <property type="entry name" value="PTHR11059"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003128">
        <property type="entry name" value="RecN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00634">
        <property type="entry name" value="recN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC_N" evidence="8">
        <location>
            <begin position="12"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR003128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH81653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="588" mass="60321" checksum="EB9542216B9E46F6" modified="2015-07-22" version="1">MRIQSLGVIDDAVVELSPGFTAVTGETGAGKTMVVTSLGLLLGGRADAALVRIGARSAVVEGRVAVAEGSPAAVRAEDAGAELDDGALLISRTVSAEGRSRAHLGGRGVPVGLLGELAEDLVAVHGQTDQQGLLKPARQRQALDRYAGDAVAVPLAKYAAAYRRLRAVSAELDEITTRARERLQEADLLRFGLDEVAAAEPRAGEDVELAAEAERLGHAEALAAASAAAHAALAGDPADPEAVDAGTLVAGAQRALAAVRAHDPALAGLADRLTEVGILLGDVAQELAAYGDGIDADPLRLAAVEERRSVLTHLSRKYGHEPAGGRGEAGDGSVSAVLAWAEAGAARLAELDGDDERIGELTAERDALRGELALLAEALTEARGDAAERFGAAVTAELTELAMPHARVTVDLRRTEVAADADGLEIGGRNVAYGPTGVDEAELLLAPHPGAPPRPIAKGASGGELSRVMLAVEVVFAGSDPVPTYLFDEVDAGVGGKAAVEVGRRLARLARGAQVVVVTHLPQVAAFADRQLLVEKTSDGSVTRSGVTVLDGEARVRELSRMLAGQEDSETARAHAEELLAAARAGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2W8</accession>
    <name>A0A0F7N2W8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator TrmB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_02285</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014556.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH81192">
        <property type="protein sequence ID" value="AKH81192"/>
        <property type="gene ID" value="AA958_02285"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_02285"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.490"/>
    <dbReference type="OrthoDB" id="1036370at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
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    </dbReference>
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        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
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        <location>
            <begin position="251"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH81192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="324" mass="35402" checksum="48DC84611683421C" modified="2015-07-22" version="1">MLEALGIPPYAESVYRALLAAPGRTVAQLAGELRRSERVTRRSVTELEEVGLVSRLPGRPVRLLATRPDTAVDLLVARRRRELGELQRNARALAATLSTGRQPDELLEILTGRQAIAERFGQLVRGCERELLVFDRPPYAADVTPSEEGVTARLHEQVVVRGIYAPESLEYPGALAAARRAAANGEQSRVHPQVPMKLALADRAVALLPIALDDQVDSALVIRPCALLDALVSLFELLWQQAAPLLPRPAQDRPSCSDLGLLTLLAAGVKDEAIARQLGVSPRTVTRRVAELLDELGARTRFQAGILAQRRGWLPDPEAHGRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2Y5</accession>
    <name>A0A0F7N2Y5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_02420</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the bacterial solute-binding protein 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_02420"/>
    <dbReference type="EnsemblBacteria" id="AKH81217">
        <property type="protein sequence ID" value="AKH81217"/>
        <property type="gene ID" value="AA958_02420"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_02420"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.518"/>
    <dbReference type="OrthoDB" id="847343at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018313">
        <property type="entry name" value="SBP_3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01039">
        <property type="entry name" value="SBP_BACTERIAL_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="PBPb" evidence="4">
        <location>
            <begin position="41"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH81217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="264" mass="28646" checksum="A551F9BB24402695" modified="2015-07-22" version="1">MSYRPPLPLIAIGAAAVLLAGCSSTEKSGQSGEVSLVENGKLLNCTGLPYEPFEYQDKKSGDIVGFDIELIDLVAKELDVKQEVIDTPFEGIESGAVFASNKCDLSAAGMTITDERKKKFAFSDPYFDATQALATKKGSGLDSLEALKGKRLGVQMDTTGQMYAQENAEGVEVKDYEDLGLQLQALEGGQIPAAINDNGVLYDWVKDRPDFEVSTEFDTGEQYGIGVGKDNKELLKVINDVLAKAKDDGTYDKIYQKWFGEAPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N341</accession>
    <name>A0A0F7N341_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_02790</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014640.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH81277">
        <property type="protein sequence ID" value="AKH81277"/>
        <property type="gene ID" value="AA958_02790"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_02790"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.597"/>
    <dbReference type="OrthoDB" id="498436at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="245"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="275"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="298"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="335"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="361"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="393"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH81277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="430" mass="43469" checksum="4917F5E88DDA0E96" modified="2015-07-22" version="1">MRTYRELFRAPEFTPLFAASSLQVAGLTISGLALGTHIYEQTGSPLLSALAMFGPSLAQVLGATLLLSAADRLPPRGAMTALALVYAAATTAQAAPGLPVWGAFAILVCLGLLASVGGGVRYGLLNEILPRDGYLLGRSVVNMSAGAMQITGFAVGGVLVTVLSPRGTLLVAAAAFLTGAAVARAGLGRRAPRAAGRPSVAETWRVNGLLWSSRHRRTLYLALWLPNGLVVGAESQFVPYAPDRAGALLALTALGMLTGDVLTGRVLPARWRPRLGVPLLLLLAVPYLVFALRPPPAVAAVAVTLASAGFAASLVQQERLMALTPDELSGQALGLHTSGMLTMQGVAAALAGGIAELTSPATAMAAMAALSIAVTLTLTPGLRAAGAAGRVSADGGAATAPARDPAPRPPGGGGGTRDRESGAGPRAPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3B5</accession>
    <name>A0A0F7N3B5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycosyl hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_13975</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016488.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_13975"/>
    <dbReference type="EnsemblBacteria" id="AKH83160">
        <property type="protein sequence ID" value="AKH83160"/>
        <property type="gene ID" value="AA958_13975"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_13975"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2941"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006584">
        <property type="entry name" value="Cellulose-bd_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005084">
        <property type="entry name" value="CMB_fam6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012938">
        <property type="entry name" value="Glc/Sorbosone_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022409">
        <property type="entry name" value="PKD/Chitinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000601">
        <property type="entry name" value="PKD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035986">
        <property type="entry name" value="PKD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011041">
        <property type="entry name" value="Quinoprot_gluc/sorb_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029010">
        <property type="entry name" value="ThuA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03422">
        <property type="entry name" value="CBM_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07995">
        <property type="entry name" value="GSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06283">
        <property type="entry name" value="ThuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00606">
        <property type="entry name" value="CBD_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00089">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49299">
        <property type="entry name" value="SSF49299"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50952">
        <property type="entry name" value="SSF50952"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51175">
        <property type="entry name" value="CBM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50093">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519736" evidence="3">
        <location>
            <begin position="31"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="4">
        <location>
            <begin position="714"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="domain" description="CBM6" evidence="5">
        <location>
            <begin position="909"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="391"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH83160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="1034" mass="111941" checksum="1E37208E0A90F861" modified="2015-07-22" version="1">MSCHARDIGRSLVTLLAAVLLALTALPSAAAEKAPAFKALLFTKAVGYVHGSIPAGIQMVKEEAEENGFEVDQTDDSTVFNDAALAEYDVIIMLQNSGMVWDTDEQRAAMQKYVQSGGGVAAIHNTLDMGIENEFPWWDELINGGAHMPSHSPGVLQGTAKVADKVHPSTKGLPERWERPEEWYNFDVNPRGDVHVLVTADETTYNPGGDAMGADHPISWCRNAEGGKVWATAMGHDTPAYSEEEFRDHVIGGVKWAAGAEPGDCGGTVWNGYEKVTLDDDTADPMELDVAKDGRVYYVQRAGEVQVFDPATHQTTTAGKLDVYTGGEDGLVGMELDPDFAKNGWIYLYYAPAGSAEDVNRLSRFTLKNGKLDTASEKKLLDVPAYRDRTFPEPGHTGGAVEFGPDGTLYLGTGDDVPPNLSPDWQGYAPIDWREGQEMLDAARTAGNTNDLRGKILRIKPTQKGTYTIPKGNLFAPGTSKTRPEIYAMGFRNPFRFTVDQETGYVHAADYGPDRGLPTTDRGPEGMVEYNVIKEPGNFGWPFCHGDNQPYAPYNPDTGEVGAKFDCDNLTNPSPNNTGLTELPKVQKPDIWYGYGPSENFPELGQGGSGPMGGPVYNYDPDNPSETKFPEYFDGAGFLYEWTRNYVKEVRWDENEELLKINDFLSSAKFNKPMDMTFGPDGSLYVLEWGSAFGGGNSDSGLYRIDYSQGKRSPVAKATASATNGPVPLAVDFSSEGSRDPDGDSLSFEWDFDGDGTFDSTEADPSHTYENKGDFTAQLKVTDSSGKTGYANIPITAGNTAPEVKIETPVNGKLIEFGDEIPYKVTVTDPEDGQIDCSKVFVNPALGHDDHEHSTTDLPGCEGTVDTGDLGGHPEGADLTYVLNARYQDGGGDGASSLTGYDKSVLQPKHKQAEYYDDQSGTRIVSQAGAENGKRIGDISNGDWIAFEPMSVEGMSQVAYKLSSPYGVGAIELRADGPDGQLLATTPVQNTGGWDNYQATAAVPVEALEGSHKLYLKFTSPQNNSFDVDSVTFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3C7</accession>
    <name>A0A0F7N3C7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent RecD-like DNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">recD2</name>
        <name evidence="5" type="ORF">AA958_10220</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RecD family. RecD-like subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="1"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015883.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_10220"/>
    <dbReference type="EnsemblBacteria" id="AKH82541">
        <property type="protein sequence ID" value="AKH82541"/>
        <property type="gene ID" value="AA958_10220"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_10220"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2153"/>
    <dbReference type="OrthoDB" id="961809at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01488">
        <property type="entry name" value="RecD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006345">
        <property type="entry name" value="DNA_helicase_RecD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029493">
        <property type="entry name" value="RecD-like_HHH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041451">
        <property type="entry name" value="RecD-like_SH13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027785">
        <property type="entry name" value="UvrD-like_helicase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14490">
        <property type="entry name" value="HHH_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18335">
        <property type="entry name" value="SH3_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13538">
        <property type="entry name" value="UvrD_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01448">
        <property type="entry name" value="recD_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 5" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HHH_4" evidence="3">
        <location>
            <begin position="144"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="SH3_13" evidence="4">
        <location>
            <begin position="572"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="domain" description="UvrD_C_2" evidence="2">
        <location>
            <begin position="657"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="359"/>
            <end position="363"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF18335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH82541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="738" mass="79647" checksum="D8F903ACA46CBC56" modified="2015-07-22" version="1">MTQLAVVEGVLERITYANEDNGYTVARVDTGRGGGDLLTVVGALLGAQPGESLRMEGRWGSHPQYGKQFTVENYRTVLPATVQGIRRYLGSGLIKGIGPRIAERIVDHFGVDTLDVIEEDPARLVEVPGLGPKRTKLIGAAWEEQKAIKEVMLFLQGVGVSTSIAVRIYKSYGDASISVVKNEPYRLAADVWGIGFLTADRIARSVGIPHDSPERVKAGLQYALSRSSDQGNCFLPEQQLITEAVKLLQVDTGLVIDCLDELVKEEGVVRETVPGPAGEEAVQGIYLVPFHRAEVSLAAQLLRLLRTERDRMPAFQDVDWDRALSWLGGRTGAELAPEQEQAVRLALTEKVAVLTGGPGCGKSFTVRSIVELARAKRAKVVMAAPTGRAAKRLAELTGAEASTVHRLLELKPGGDAAYDRDRPLDADLVVVDEASMLDLLLANKLAKAVPPGAHLLLVGDVDQLPSVGAGEVLRDLLAEGGPVPAVRLTRIFRQARQSGVVTNAHRINSGVQPLTQGLADFFLFAEDDTEAAGRLTVDVAARRVPARFGLDPRRDVQVLAPMHRGPAGAGVLNGLLQEAVTPGRPGLPEKRFGGRTFRVGDKVTQIRNNYEKGSNGVFNGTVGVVTALDADEQRLTVLTDEDEEVPYDFDELDELTHAYAVTIHRSQGSEYPAVVIPVTTGAWMMLQRNLLYTAVTRAKKLVVLVGSRKALGQAVRTVSAGRRCTALDHRLRGRVGLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3F3</accession>
    <name>A0A0F7N3F3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dienelactone hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_06460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_06460"/>
    <dbReference type="EnsemblBacteria" id="AKH81909">
        <property type="protein sequence ID" value="AKH81909"/>
        <property type="gene ID" value="AA958_06460"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_06460"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1349"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DLH" evidence="1">
        <location>
            <begin position="2"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="182" mass="19401" checksum="E78B1742DBD089C6" modified="2015-07-22" version="1">MHETAERWRAAGHEVVVPDLYDGRTPETEEEGQEVRDEIGTDELLARAVKAAAPYSAGGVLYAGFSLGGALAQNLALADRHARGLLLMHGTSDIADGAAAASGELPVQLHVADPDPYETHDWLTAWYLRMGRAGADVEVFRYPGAGHLFTDPGLADYDAEAAQSARQVADAFVAELDVRSAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3R2</accession>
    <name>A0A0F7N3R2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pup deamidase/depupylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_04010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Pup ligase/Pup deamidase family. Pup deamidase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_04010"/>
    <dbReference type="EnsemblBacteria" id="AKH81492">
        <property type="protein sequence ID" value="AKH81492"/>
        <property type="gene ID" value="AA958_04010"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_04010"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.841"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019941">
        <property type="term" value="P:modification-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022366">
        <property type="entry name" value="Pup_deamidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004347">
        <property type="entry name" value="Pup_ligase/deamidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42307">
        <property type="entry name" value="PTHR42307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03136">
        <property type="entry name" value="Pup_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018077">
        <property type="entry name" value="UCP018077"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03688">
        <property type="entry name" value="pupylate_PafA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR018077-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH81492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="497" mass="56092" checksum="3E0C4E52F74ABA73" modified="2015-07-22" version="1">MGIETEYGISVPGHPNANAMLTSSQVVNAYAAAMHRARRARWDFEEENPLRDARGFDLAREAADSSQLTDEDIGLANVILTNGARLYVDHAHPEYSAPEVTNPRDAVLWDKAGERIMAEAAERAGQLPGAQPILLYKNNTDNKGASYGCHENYLMKRETPFSDIVRHLTPFFVSRQVFTGAGRVGIGQDGNEHGFQISQRADYFEVEVGLETTLKRPIINTRDEPHADAEKYRRLHVIIGDANLSEISTYLKLGTTALVLSMIEDDFIAVDLAVEQPVRTLHQVSHDPTLRHQVVLRSGRTLTAVQLQMEYCELARKYVEERFGADADEQTKDVLTRWEDTLNRLEADPMSLSGELDWLAKRELLEGYRRRDALDWDAARLALVDLQYADVRPEKGLYNRLAARGRLKRLLTEDEVLRAVKNPPEDTRAYFRGRCLEQYADDVAAASWDSVIFDLPGRDSLQRVPTLEPLRGTRNHVKELLDRCRTAEELVRVLSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4B2</accession>
    <name>A0A0F7N4B2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_05220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_05220"/>
    <dbReference type="EnsemblBacteria" id="AKH81697">
        <property type="protein sequence ID" value="AKH81697"/>
        <property type="gene ID" value="AA958_05220"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_05220"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1096"/>
    <dbReference type="OrthoDB" id="1704621at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="141" mass="14502" checksum="5E6BFAAF892CE3D5" modified="2015-07-22" version="1">MTSVASEHAEEHAEGHVAEAAPAEDAGGGEPAVPAGERGATRIEDRVIAKIASQAAREALLGAPGTDAAHAAVVVRGDTARVRVGVHLGFPSDLGAQCCAVSRAVTERVRALVGLEVPEVAVEVERLHATERPNAPRGRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4B9</accession>
    <name>A0A0F7N4B9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9 10">Chromosomal replication initiator protein DnaA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">dnaA</name>
        <name evidence="15" type="ORF">AA958_16210</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 11">Belongs to the DnaA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016801.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_16210"/>
    <dbReference type="EnsemblBacteria" id="AKH83495">
        <property type="protein sequence ID" value="AKH83495"/>
        <property type="gene ID" value="AA958_16210"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_16210"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3415"/>
    <dbReference type="OrthoDB" id="219876at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006275">
        <property type="term" value="P:regulation of DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06571">
        <property type="entry name" value="Bac_DnaA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1750.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00377">
        <property type="entry name" value="DnaA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001957">
        <property type="entry name" value="Chromosome_initiator_DnaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020591">
        <property type="entry name" value="Chromosome_initiator_DnaA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018312">
        <property type="entry name" value="Chromosome_initiator_DnaA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013317">
        <property type="entry name" value="DnaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013159">
        <property type="entry name" value="DnaA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038454">
        <property type="entry name" value="DnaA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010921">
        <property type="entry name" value="Trp_repressor/repl_initiator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30050:SF2">
        <property type="entry name" value="PTHR30050:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00308">
        <property type="entry name" value="Bac_DnaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08299">
        <property type="entry name" value="Bac_DnaA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00051">
        <property type="entry name" value="DNAA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00760">
        <property type="entry name" value="Bac_DnaA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48295">
        <property type="entry name" value="SSF48295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00362">
        <property type="entry name" value="DnaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01008">
        <property type="entry name" value="DNAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 9 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="13">
        <location>
            <begin position="341"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_DnaA_C" evidence="14">
        <location>
            <begin position="555"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="85"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="231"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="349"/>
            <end position="356"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AKH83495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="648" mass="70000" checksum="A7409E54E461F118" modified="2015-07-22" version="1">MADLPADLAAVWPRVLERLLADEQGVEAKDHRWLRDCQPLVLVAGTAVLAVPNEYAKGVFEGRLASKITDALSHACRQPIGLAVTVSPGEPESKPQQGPPAQPGPESGGHGPHVPHSPQAPQPPAHEQAAHPGAPHLPLPHTAAQPTHQSHQPPHQSHGGPLPEPPYDAYSRPAPGDDRLPTAAPTYPEYAQPRPAPAAWPRADHHPGPPGTQPDTSAGPDGTDFYPAHDHLAQRPAHDRYAHPGGHTGGHTGGHTGGHTGGHSPSGAPIPPLVQAMGNVELPAPSGAPGPLAAQPAPATGPGEPTARLNPKYLFDTFVIGASNRFAHAAAVAVAEAPAKAYNPLFIYGESGLGKTHLLHAIGHYARSLYPGTRVRYVSSEEFTNEFINSIRDGKADTFRKRYRDMDILLVDDVQFLASKESTQEEFFHTFNTLHNANKQIVLSSDRPPKQLITLEDRLRNRFEWGLITDVQPPELETRIAILRKKAVQEQLNAPPEVLEFIASRISRNIRELEGALIRVTAFASLNRQPVDLGLTEIVLKDLIPGGEDTAPEITAAAIMAATADYFGLTVEDLCGSSRSRVLVTARQIAMYLCRELTDLSLPKIGAQFGNRDHTTVMHADRKIRALMAERRSIYNQVTELTNRIKNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4M4</accession>
    <name>A0A0F7N4M4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Growth inhibitor PemK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_05840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015155.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_05840"/>
    <dbReference type="EnsemblBacteria" id="AKH81802">
        <property type="protein sequence ID" value="AKH81802"/>
        <property type="gene ID" value="AA958_05840"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_05840"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1222"/>
    <dbReference type="OrthoDB" id="1924690at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003477">
        <property type="entry name" value="PemK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011067">
        <property type="entry name" value="Plasmid_toxin/cell-grow_inhib"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02452">
        <property type="entry name" value="PemK_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="152" mass="17298" checksum="8665E8F34B1EDB03" modified="2015-07-22" version="1">MTTPTDENGHASLPGQHGPTATTEIDPRAAGVVRTSYAPDPDGDPDPGEIVWTWVPYEENDGRGKDRPVLVVARETAGTVLAVQLSSRRRDDDHDWVRIGAGPWDREGRESWVDLDRVLRLHDGGMRREACSLDRRRFHLVEHRLRLRYGWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4N5</accession>
    <name>A0A0F7N4N5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Deoxyguanosinetriphosphate triphosphohydrolase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_08945</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the dGTPase family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015681.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_08945"/>
    <dbReference type="EnsemblBacteria" id="AKH82334">
        <property type="protein sequence ID" value="AKH82334"/>
        <property type="gene ID" value="AA958_08945"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_08945"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1884"/>
    <dbReference type="OrthoDB" id="370035at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008832">
        <property type="term" value="F:dGTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006203">
        <property type="term" value="P:dGTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01212">
        <property type="entry name" value="dGTPase_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006261">
        <property type="entry name" value="dNTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020779">
        <property type="entry name" value="dNTPase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023023">
        <property type="entry name" value="dNTPase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026875">
        <property type="entry name" value="PHydrolase_assoc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11373:SF32">
        <property type="entry name" value="PTHR11373:SF32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13286">
        <property type="entry name" value="HD_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01353">
        <property type="entry name" value="dGTP_triPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="3">
        <location>
            <begin position="71"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH82334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="426" mass="45270" checksum="84E0C140BC184A08" modified="2015-07-22" version="1">MGYTDADLERWAPEPDKRPGRTAFQRDRARVLHSAALRRLAGKTQVVTPGVSDDGVGGQALTFADATPRTRLTHSLECAQVGRELGAALGCDPDLVETACLAHDLGHPPFGHNGEQVLDELAAPCGGFEGNAQSLRLLTRLEPKRFTDDGRSVGLNLTRAALDAATKYPWRRGGHPAGPDAVKFGVYPDDGPVFDWLRAGAPGGPAGRTCFEAQVMDWSDDVAYSVHDVEDGLHAGHLDPAVLLAGPERAEVFAVAAGRYAPGTDAAELAEALDRLLAQEWWPHGYDGTAAAQARLKDATSQLIGRFCLAAEGATRAAYGTGALSRYAAELIVPRAERLECAVLKAVADRFVMQRPDQARLRADQRVVLGELAGALTAGAPAGLDPQFRALYEEAADDAGRLRAVVDQIAALTDAAARRLHARLTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4R3</accession>
    <name>A0A0F7N4R3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Formyltetrahydrofolate deformylase</fullName>
            <ecNumber evidence="3">3.5.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Formyl-FH(4) hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">purU</name>
        <name evidence="5" type="ORF">AA958_12970</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>(6S)-10-formyltetrahydrofolate + H2O = (6S)-5,6,7,8-tetrahydrofolate + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19833"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="EC" id="3.5.1.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Purine metabolism; IMP biosynthesis via de novo pathway; formate from 10-formyl-5,6,7,8-tetrahydrofolate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PurU family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.10" evidence="3"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016320.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_12970"/>
    <dbReference type="EnsemblBacteria" id="AKH82986">
        <property type="protein sequence ID" value="AKH82986"/>
        <property type="gene ID" value="AA958_12970"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_12970"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2730"/>
    <dbReference type="OrthoDB" id="979667at2"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008864">
        <property type="term" value="F:formyltetrahydrofolate deformylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016742">
        <property type="term" value="F:hydroxymethyl-, formyl- and related transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04875">
        <property type="entry name" value="ACT_F4HF-DF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08648">
        <property type="entry name" value="FMT_core_Formyl-FH4-Hydrolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01927">
        <property type="entry name" value="PurU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041729">
        <property type="entry name" value="Formyl-FH4-Hydrolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004810">
        <property type="entry name" value="PurU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044074">
        <property type="entry name" value="PurU_ACT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42706">
        <property type="entry name" value="PTHR42706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01575">
        <property type="entry name" value="FFH4HYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="SSF53328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00655">
        <property type="entry name" value="PurU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="3" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Formyl_trans_N" evidence="4">
        <location>
            <begin position="86"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH82986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="282" mass="31426" checksum="6D36DC523CC5A9E5" modified="2015-07-22" version="1">MSEYVLTLSCPDKKGIVHAVSSYLFMTDCNIEDSQQYGDPTTGLFFMRVHFSAEPQANVDKLRASFAAVAESWAMDWQIHEQGAKMRVLLMVSKFGHCLNDLLFRARIGALPVEIAAVVSNHTDFGELVGSYGIPFHHVPVTKDTKAEAEQKLLELVRAEDVELVVLARYMQVISDDLCKQLEGRIINIHHSFLPSFKGAKPYHQAHARGVKLIGATAHYVTADLDEGPIIEQEVERVGHEVTPEQLVAVGRDVECQALARAVKWHSEHRVLLNGTRTVVFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4S5</accession>
    <name>A0A0F7N4S5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_17175</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016959.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH83655">
        <property type="protein sequence ID" value="AKH83655"/>
        <property type="gene ID" value="AA958_17175"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_17175"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3611"/>
    <dbReference type="OrthoDB" id="1384345at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="116"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="226"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="293"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="357"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="384"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="21"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH83655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="416" mass="41838" checksum="0491EEA3F98DEF51" modified="2015-07-22" version="1">MTTTSSDAQPRTRQAGLPWSALLALGTAVFITSLTETLPAGVLPEMSTSLGTSSGATGQAVTVYAAGTALTAIPLATATASVPRKPLLLGAMAVFLVANTLTAAAQGYIVLLAGRFLAGVAAGLAWAILAGYARRIAPVGLEGRAIAVAMTGIPVALSLGVPAGTLIGEQVGWRAAFGAVSLVTLAVIGWISVSVPGVGQPAIEQADPNRSDPAPESAKSPLRQTLAVPGVAAIMVTVTTFVLGHTIIYAYIAPYLQHAGLRPATDAVLLAFGVACLVSIWYVGRHVDRRPRALMVTGAALFTLATAALAVTTTHTIVWVAAVLWGLGWGGAPTLLQTAAGQAGMRRSTAAADTAQAVLVTLWNTAMALGGIIGGLLLQSSGVTVVAASAAALGAVSLVIVAGARHRAFPHTQATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4Z0</accession>
    <name>A0A0F7N4Z0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphate-specific transport system accessory protein PhoU</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_13485</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Plays a role in the regulation of phosphate uptake.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the PhoU family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016406.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_13485"/>
    <dbReference type="EnsemblBacteria" id="AKH83076">
        <property type="protein sequence ID" value="AKH83076"/>
        <property type="gene ID" value="AA958_13485"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_13485"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2836"/>
    <dbReference type="OrthoDB" id="1648549at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030643">
        <property type="term" value="P:cellular phosphate ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045936">
        <property type="term" value="P:negative regulation of phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028366">
        <property type="entry name" value="P_transport_PhoU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038078">
        <property type="entry name" value="PhoU-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026022">
        <property type="entry name" value="PhoU_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42930">
        <property type="entry name" value="PTHR42930"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01895">
        <property type="entry name" value="PhoU"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003107">
        <property type="entry name" value="PhoU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02135">
        <property type="entry name" value="phoU_full"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PhoU" evidence="4">
        <location>
            <begin position="16"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="PhoU" evidence="4">
        <location>
            <begin position="122"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR003107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH83076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="224" mass="24875" checksum="B1E494BFD12AE06D" modified="2015-07-22" version="1">MRDSYHEELDSIGEGLVDMARLVGSAMGRATAALLDADLQLAESVIAGDEKVDDLQRELETRAIQLLARQQPVATDLRIVVTSLRMSADLERAGDLAKHVAKLARLRYPGRCIPDDLHATVLEMGQLAQRLMAKTAEVVTTKNVDLALELEQDDDRMDYLHRKIFQHLMDDRWKHGIETAVDVTLIGRYYERFADHAVACSGRVVYLVTGEHADELSAAPVEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4Z3</accession>
    <name>A0A0F7N4Z3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_09690</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015797.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_09690"/>
    <dbReference type="EnsemblBacteria" id="AKH82454">
        <property type="protein sequence ID" value="AKH82454"/>
        <property type="gene ID" value="AA958_09690"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_09690"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2039"/>
    <dbReference type="OrthoDB" id="1181903at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="21"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="249"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="57"/>
            <end position="64"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH82454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="268" mass="28193" checksum="ED3CDE4505F16178" modified="2015-07-22" version="1">MRLRTRGERQDHGAPAPGHAVELRGVQRRYGRGAGVVHALRGIDLALPRGTYTAVMGPSGSGKSTLLQCAAGLDRPTAGSVLLGGTELTRLGENKLTELRRSRLGFVFQAFNLLPSLTVSQNVLLPMRLAGFRADHARAAEVLAQVGLAAHGRRRPAELSGGQQQRVAIARALVTRPDVIFADEPTGALDTRTAAEVLALLRHAVDSLGATVVMVTHDPVAASYADVALFLADGALAGSLQRPTAEQVAARMTALDPRDTARGAERAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N529</accession>
    <name>A0A0F7N529_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_06500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the YggT family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018837714.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_06500"/>
    <dbReference type="EnsemblBacteria" id="AKH81917">
        <property type="protein sequence ID" value="AKH81917"/>
        <property type="gene ID" value="AA958_06500"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_06500"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1357"/>
    <dbReference type="OrthoDB" id="2069856at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003425">
        <property type="entry name" value="CCB3/YggT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02325">
        <property type="entry name" value="YGGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH81917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="95" mass="10764" checksum="57D573BB5679CB9D" modified="2015-07-22" version="1">MDVALQVIYIALFVFLIVLIFRLIMDYVFMFARSWEPGKAMVVLLEGAYTVTDPPLKLLRRFIPPLRLGGVALDLSFFVLMIIVYILLTVVGGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5Q4</accession>
    <name>A0A0F7N5Q4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-CoA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_11445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016080.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_11445"/>
    <dbReference type="EnsemblBacteria" id="AKH82744">
        <property type="protein sequence ID" value="AKH82744"/>
        <property type="gene ID" value="AA958_11445"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_11445"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2409"/>
    <dbReference type="OrthoDB" id="1389630at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017523">
        <property type="entry name" value="CHP03089"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03089">
        <property type="entry name" value="TIGR03089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="17"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="247" mass="25739" checksum="570D691663A29F11" modified="2015-07-22" version="1">MNPTAATPAALLDAALAADPARPLVTYYDDTTGERVELSVATFANWVAKTANLLQGDLAAEPGDRLALLLPAHWQTAVWLLACAATGVTAVPADPDPAAADLVVSGPGALEQARACTGERVALSLRPLGARFPQPPDGFLDYAVEVPGQGDRFQPYAPADPDAPALEAPGARFTAAELVARARADAQSRALAPGSRTLSTLGYDTWEGLSAGLYAPLAAGAGVVLCPYLDRLTLEQQEKRRADERIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6I9</accession>
    <name>A0A0F7N6I9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">F420-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_12805</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016293.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH82959">
        <property type="protein sequence ID" value="AKH82959"/>
        <property type="gene ID" value="AA958_12805"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_12805"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2690"/>
    <dbReference type="OrthoDB" id="1434838at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019921">
        <property type="entry name" value="Lucif-like_OxRdtase_Rv2161c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03619">
        <property type="entry name" value="F420_Rv2161c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="2">
        <location>
            <begin position="18"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH82959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="305" mass="32798" checksum="DA0B5431823E10DB" modified="2015-07-22" version="1">MRISVTVFLTDETVRPPALARELEERGFHGLYLPEHTHIPVSRDTPAPMGEPLPREYGRTLDPFVALGQAAAVTERLALGTGITLVAQHDPIVLAKQVATLDFLSGGRLTLGVGFGWNEEEADDHGVDWRGRRELGRRKMGLMNALWAPEPTAYDGEAEAQEAADTAGDEAGGSVPRTAVRASEAHPKPVQAPRPRKGAPPLHGPRTLLGGRPGPKLFAHVAEYADGWMPIGGGGLTDSIPRLRQVWEDAGRDPAALEVVPYAVRPSEGKLAYFAAQGVRETVVQLPPAGETEVLRALDAYAQFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6S0</accession>
    <name>A0A0F7N6S0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">DNA repair protein RadA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">radA</name>
        <name evidence="9" type="ORF">AA958_17875</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.</text>
    </comment>
    <comment type="function">
        <text evidence="5">Plays a role in repairing double-strand DNA breaks, probably involving stabilizing or processing branched DNA or blocked replication forks.</text>
    </comment>
    <comment type="domain">
        <text evidence="5">The middle region has homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the RecA family. RadA subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017068.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_17875"/>
    <dbReference type="EnsemblBacteria" id="AKH83766">
        <property type="protein sequence ID" value="AKH83766"/>
        <property type="gene ID" value="AA958_17875"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_17875"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3765"/>
    <dbReference type="OrthoDB" id="505485at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000725">
        <property type="term" value="P:recombinational repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01498">
        <property type="entry name" value="RadA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004504">
        <property type="entry name" value="DNA_repair_RadA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041166">
        <property type="entry name" value="Rubredoxin_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18073">
        <property type="entry name" value="Rubredoxin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00416">
        <property type="entry name" value="sms"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0346">Stress response</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RECA_2" evidence="8">
        <location>
            <begin position="69"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Lon-protease-like" evidence="5">
        <location>
            <begin position="355"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="451"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="RadA KNRFG motif" evidence="5">
        <location>
            <begin position="255"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="463"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="98"/>
            <end position="105"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH83766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="484" mass="50688" checksum="477F48C189E0F558" modified="2015-07-22" version="1">MASRKSGGRDRPAYRCAECGWSTVKWLGRCPECQAWGTIEEVGAPAVKTTAAGRVTTPALPIAQVDARRVEARSTGVPELDRVLGGGLVPGAVVLMAGEPGVGKSTLLLDVAAKAAVGGERTLYVTGEESAGQVRLRADRIGALSDGLYLAAETDLAAVLAHLDEVRPALLVLDSVQTVASGEIDGAPGGMAQVREVAGALIRASKERGMATILVGHVTKDGAIAGPRLLEHLVDVVLHIEGDRHARLRLVRGMKNRYGATDEVGCFELHDEGIIGLADPSGLFLTRRDEPVPGTCLTVTLEGRRPLVAEVQALTVDSQIPSPRRTTSGLETSRVSMMLAVLEQRGDIRALSKRDIYSATVGGVKLSEPAADLAVALALASAASDTPLPKNLVAIGEVGLAGEVRRVTGVARRLAEAARLGFTQALVPADPGKVPAGMKVREVADIGDALRALPAGRRRTGGGSREPAGEREPRESRQPEEARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6S2</accession>
    <name>A0A0F7N6S2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Methylmalonate-semialdehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_13325</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016380.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_13325"/>
    <dbReference type="EnsemblBacteria" id="AKH83049">
        <property type="protein sequence ID" value="AKH83049"/>
        <property type="gene ID" value="AA958_13325"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_13325"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2803"/>
    <dbReference type="OrthoDB" id="490746at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004491">
        <property type="term" value="F:methylmalonate-semialdehyde dehydrogenase (acylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07085">
        <property type="entry name" value="ALDH_F6_MMSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010061">
        <property type="entry name" value="MeMal-semiAld_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43866">
        <property type="entry name" value="PTHR43866"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01722">
        <property type="entry name" value="MMSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="3">
        <location>
            <begin position="17"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH83049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="502" mass="52408" checksum="7813937E2F3EDA8F" modified="2015-07-22" version="1">MHTIEHWIAGGAAASVSAASRTAPVYDPATGREQARVLLAEAADVDAAVNAAAKAYDTWRDSSLSQRMRVMFAFRELLVRHEDELARVISAQHGKIISDARGEIVRGREVVEYACGIADALKGGYSDQYSRGVDVLSFREPLGVCAGITPFNFPAMVPLWMHPIAIATGNTFVLKPSERDPSASNLIARLYADAGLPDGVFNVVHGDKTAVDALLDHPGIAAVSFVGSTPIATYVHERGTAAGKRVQALGGAKNHAVVLPDADLEYASDQLVAAAYGSAGERCMAISVAVAVGDAADPLVEVLERKARAVRVGPGDDPASEMGPLVTRAAQERVSGAVASAAAQGATVVVDGRDLKVAGHEEGFFTGPTLLDHVSAAMDAYRTEIFGPVLAVIRVATLDEAIALINANPYGNGTALFTGDGGAARRFQRGVHVGMVGINVPVPVPMAAYSFGGWKDSLIGDSPVHGPEGVRFYTRPKVVTTRWPAGGNPAARGAAFAFPTAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7D4</accession>
    <name>A0A0F7N7D4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Carboxypeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_22475</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_22475"/>
    <dbReference type="EnsemblBacteria" id="AKH84505">
        <property type="protein sequence ID" value="AKH84505"/>
        <property type="gene ID" value="AA958_22475"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_22475"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4730"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03859">
        <property type="entry name" value="M14_CPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033810">
        <property type="entry name" value="Carboxypeptidase_T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00765">
        <property type="entry name" value="CRBOXYPTASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00132">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00133">
        <property type="entry name" value="CARBOXYPEPT_ZN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519137" evidence="2">
        <location>
            <begin position="40"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M14" evidence="3">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M14" evidence="4">
        <location>
            <begin position="335"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH84505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="460" mass="50296" checksum="9122F1A71C52A0A9" modified="2015-07-22" version="1">MHHPTPPHPGAGMRLRIRSVTLTAVLALTAAGALSAAGAEPGAQPARASGTGASQAQEREQIRQYEVLGQTGREARTRLAATGVSVDEVRDHSVVVSADGAQARQLRALGYRLEQLPAPPARLADKPPTTLDFPPADSRYHNYAEMTAEIDRLIAAKPDLISKRVIGTSYEGRDIVAVKVSDNVRTDENEPEVLFTHHQHAREHLTVEMALYLLGEFADGYGTDQRITDVVNGREIWIVPDLNPDGGEYDIATGSYRSWRKNRQPNSGSSAVGTDLNRNWNYRWGCCGGSSGSPSSETYRGTAAESAKEVKVVADFARSRVVGGKQQIKAGIDFHTYSELVLWPYGYTYNDTGPGLTQDDRDAFAAVGQKMAASNGYTPQQSSDLYITDGSVNDYLWGEQKIFSYTFEMYPRSASGGGFYPPDEVIDRETSRNRDAVLQLLENADCMYRSIGKEAQYCTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7G0</accession>
    <name>A0A0F7N7G0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Putative fluoride ion transporter CrcB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">crcB</name>
        <name evidence="10" type="ORF">AA958_15105</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Important for reducing fluoride concentration in the cell, thus reducing its toxicity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the CrcB (TC 9.B.71) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016639.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_15105"/>
    <dbReference type="EnsemblBacteria" id="AKH83324">
        <property type="protein sequence ID" value="AKH83324"/>
        <property type="gene ID" value="AA958_15105"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_15105"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3183"/>
    <dbReference type="OrthoDB" id="1942863at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903425">
        <property type="term" value="F:fluoride transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00454">
        <property type="entry name" value="CrcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003691">
        <property type="entry name" value="CrcB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28259">
        <property type="entry name" value="PTHR28259"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02537">
        <property type="entry name" value="CRCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00494">
        <property type="entry name" value="crcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AKH83324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="124" mass="12555" checksum="3E890EEA58EFCA66" modified="2015-07-22" version="1">MNWLLVIAGGMAGAPLRYVTDRAVQLRHGSPFPWGTLAVNVTGCLILGTLAGATLAGAAPESVRLLLGTGLCGALTTYSTFSYEVLRLAEKGRGRYAAAYVGASLAVGLGAAFLGAVAGEAVWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7K3</accession>
    <name>A0A0F7N7K3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_22980</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017847.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_22980"/>
    <dbReference type="EnsemblBacteria" id="AKH84590">
        <property type="protein sequence ID" value="AKH84590"/>
        <property type="gene ID" value="AA958_22980"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_22980"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4841"/>
    <dbReference type="OrthoDB" id="1112046at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="25"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="347"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="284"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="290"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="57"/>
            <end position="64"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="390"/>
            <end position="397"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH84590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="555" mass="59590" checksum="175FA3F811EF663D" modified="2015-07-22" version="1">MLRTDSSSPFSALSRDLPAGAAAHVRAEGIAVRLGERTVLSGADVTVSAGSRLAVVGENGRGKTTLLHVLAGTLTPDAGTVSRTGTLALVEQTLHAEDERTVGDLVKEAVGDSLTALDLLDGATEALAQGSPGADDAYARALEVATALDAWDAERRVDVALEGLGACTDRDRRLATLSVGQRYRVRLAVVLGSATDLLLLDEPTNHLDAAALGFLERSLRERAGGVAVVSHDRALLRAVATTFLDLDPSRDGLPRLYAGGYDGWVEGRRRERERWEQEHAAQQAEHAQLTRAAEEARGRLQTGWRPDKGTGKHQRATRAAGVVQTFNRRVEDLERHRITVPEPPRSLSFPDLRTRAGRPVLHGQDLTVAGRLHQPVEVTISGGDRLLLTGPNGAGKSTLLGVLAGQLHPTGGSLHVHHDARVVLLSQEVPVWNPEHTAYRAYEAHVDRLRSRGLKGSAPSLSGLGLLDATALRTPVGRMSQGQQRRLHLAMCLAEQPDLLMLDELTNHLSASLVDELTRALTTTPCAVVVATHDRQLLADLADWPRLELASAPRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7K7</accession>
    <name>A0A0F7N7K7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">ATP-dependent Clp protease proteolytic subunit</fullName>
            <ecNumber evidence="2">3.4.21.92</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Endopeptidase Clp</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">clpP</name>
        <name evidence="4" type="ORF">AA958_15425</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2 3">Belongs to the peptidase S14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.92" evidence="2"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016680.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_15425"/>
    <dbReference type="EnsemblBacteria" id="AKH83368">
        <property type="protein sequence ID" value="AKH83368"/>
        <property type="gene ID" value="AA958_15425"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_15425"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3246"/>
    <dbReference type="OrthoDB" id="1728970at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07017">
        <property type="entry name" value="S14_ClpP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00444">
        <property type="entry name" value="ClpP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001907">
        <property type="entry name" value="ClpP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023562">
        <property type="entry name" value="ClpP/TepA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381">
        <property type="entry name" value="PTHR10381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00574">
        <property type="entry name" value="CLP_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00127">
        <property type="entry name" value="CLPPROTEASEP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0720">Serine protease</keyword>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH83368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="198" mass="21447" checksum="3414C44CEEA10C59" modified="2015-07-22" version="1">MSQYTIPNVVERTAHGERAYDIYSRLLSERIIFLGTEIDDGVANVVIAQLLHLESASPGSEISIYINSPGGSYTSLMAIYDTMTFVGAPISTYCVGQAASTAAVLLAGGEKGRRFVLEHARVLLGQPASGVRRGTVSDLSLEAKEILRIRAQMEEVLARHTGHEVATLRADTDRDKVFTAQDAVAYGLADQVISKRHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7P1</accession>
    <name>A0A0F7N7P1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_19745</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017333.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_19745"/>
    <dbReference type="EnsemblBacteria" id="AKH84041">
        <property type="protein sequence ID" value="AKH84041"/>
        <property type="gene ID" value="AA958_19745"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_19745"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4161"/>
    <dbReference type="OrthoDB" id="447734at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH84041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="426" mass="46093" checksum="B1C2329DFD774C56" modified="2015-07-22" version="1">MQRRGFLKAAAGAAGAAALPLSACGDGSGGGDVTLKLVAAEYGTGESDTARRYWEQLAAKFSNDTPGISVDIEIIPWEDIDAKVDKMVKDGNPPDIAQMGPYAAYSSRDMLYSTDELLSIPTQANFVPSLAAAGEVNRVQYGMPFVSSSRLLFYNKSLFEDAGLSTDPEDAPQDWGELLDVAQALKDTGVKVPYALPLGPEEAQGETLMWMISGGGAYTDDVGSYTIDSEQNIHTFNWIRDNLVGAGLTYAAPSETNRRTAFADFVKGDVGMIFGHPTLMQDLRREKVDFGIAEKLPGRDGPSESTMGVADWIMAFKANGHRSQIGKFLDVLFDDTNVLKFAQRYDLLPTTVSGVDKLSEGRKDLQPFLDQLQTAVFYPDNKTSWARVNAELKKQIGKAAEAGGEPPERVLTNLQSIAESASTTEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7V8</accession>
    <name>A0A0F7N7V8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_23530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017940.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_23530"/>
    <dbReference type="EnsemblBacteria" id="AKH84685">
        <property type="protein sequence ID" value="AKH84685"/>
        <property type="gene ID" value="AA958_23530"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_23530"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4962"/>
    <dbReference type="OrthoDB" id="1755145at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="199" mass="20871" checksum="BA8DE482D9D36203" modified="2015-07-22" version="1">MSNSPTGGPPLAADPLTRAVLELDEYAAGFGWDRPPRLFALVDTARLRAQEPDLAERLNLDAGQGAGDGTAAESAAGPAAQVSYTPIEQQELPTGQPLDEFLGTIAWPDAVGGCALTVERLMLPPAAEAEVPDDLDEEGLAAWVAGHPRREEVRMTVGVLRDGSREAAVRLRSKDAPTEVLTGPDLVPGLARALAATFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7Y0</accession>
    <name>A0A0F7N7Y0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptide deformylase</fullName>
            <shortName evidence="2">PDF</shortName>
            <ecNumber evidence="2">3.5.1.88</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Polypeptide deformylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">def</name>
        <name evidence="4" type="ORF">AA958_23630</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>H2O + N-terminal N-formyl-L-methionyl-[peptide] = formate + N-terminal L-methionyl-[peptide]</text>
            <dbReference type="Rhea" id="RHEA:24420"/>
            <dbReference type="Rhea" id="RHEA-COMP:10639"/>
            <dbReference type="Rhea" id="RHEA-COMP:10640"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:49298"/>
            <dbReference type="ChEBI" id="CHEBI:64731"/>
            <dbReference type="EC" id="3.5.1.88"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="2">Binds 1 Fe(2+) ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the polypeptide deformylase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.88" evidence="2"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017955.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_23630"/>
    <dbReference type="EnsemblBacteria" id="AKH84700">
        <property type="protein sequence ID" value="AKH84700"/>
        <property type="gene ID" value="AA958_23630"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_23630"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4980"/>
    <dbReference type="OrthoDB" id="1649129at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042586">
        <property type="term" value="F:peptide deformylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00487">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.45.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00163">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023635">
        <property type="entry name" value="Peptide_deformylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036821">
        <property type="entry name" value="Peptide_deformylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10458">
        <property type="entry name" value="PTHR10458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01327">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004749">
        <property type="entry name" value="Pep_def"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01576">
        <property type="entry name" value="PDEFORMYLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56420">
        <property type="entry name" value="SSF56420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00079">
        <property type="entry name" value="pept_deformyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH84700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="215" mass="24009" checksum="6276B99FA69D1014" modified="2015-07-22" version="1">MTQQAEQEQAGREAESPDVFIDDVKDAEARERAARERGTARPITVVGNPVLHRECRDVTEFDDVLRRLVDDMFASQRAAEGVGLAANQIGVDLKVFVYDCPDDDGVRHVGAVCNPVLEELPADRRQLDDGNEGCLSVPGAYMSLARPDYAVVSGRDLDGNPLRVAGTGYFARCLQHETDHLYGRLYIDRLSKRERKDVMEQMAENTPRYETVPND</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N875</accession>
    <name>A0A0F7N875_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_23995</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018017.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_23995"/>
    <dbReference type="EnsemblBacteria" id="AKH84765">
        <property type="protein sequence ID" value="AKH84765"/>
        <property type="gene ID" value="AA958_23995"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_23995"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5057"/>
    <dbReference type="OrthoDB" id="1359757at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH84765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="255" mass="26762" checksum="5C016776252C59C9" modified="2015-07-22" version="1">MRIELASDPAAPPAPNEDYAAVALPASGTGGAVVVLDGVTPPRDGDTGCVHGVPWFVARLGGAFLELAGTRETPLTDCLAAAIRRTAAAHGPACDLTHRRTPQATVAAARWDGERVEHLVLCDAALLLEGPDGAVRPVLDLRLSQVPRSRPAEEMRNVEGGFFTAAADPEVAARAVVGSVPRTEVAALTALTDGVTRWTEVFGFGDWTALLQRVRKAGPRGVVAEVRAAEAADADRSRYRRGKVHDDASAVLVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8F9</accession>
    <name>A0A0F7N8F9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_13185</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016359.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH83027">
        <property type="protein sequence ID" value="AKH83027"/>
        <property type="gene ID" value="AA958_13185"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_13185"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2775"/>
    <dbReference type="OrthoDB" id="1570162at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004111">
        <property type="entry name" value="Repressor_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02909">
        <property type="entry name" value="TetR_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="18"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH83027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="261" mass="28832" checksum="D14AF326F75AA231" modified="2015-07-22" version="1">MALLWGIDERAKRGPKPGISVDRIVFTAIGIADAEGLEAVSMRKIAGHLGVGTMSLYRHVPGKAELLDLMLDGVGSIEPEDAEHLRSQPTWRDRMRELAHSFWEHYLAHPWLLHVDQGRPVLGPNGLDSFELALSVFDGLLLTDQEKVGFITSLDSTAAGLARVHVNAKQAEARTGISDQEFWEAQSPALESAMESGRYPRIASLADDSFSALDEETFTFAMDRMLDGLEVLIEHRRKTGWTPPPAGARVFDEECREGETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8M5</accession>
    <name>A0A0F7N8M5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_21800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017653.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_21800"/>
    <dbReference type="EnsemblBacteria" id="AKH84391">
        <property type="protein sequence ID" value="AKH84391"/>
        <property type="gene ID" value="AA958_21800"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_21800"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4591"/>
    <dbReference type="OrthoDB" id="1497607at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="10"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="184" mass="20466" checksum="922EE9564E8DA742" modified="2015-07-22" version="1">MGVFLETSRLVLRPFGAGDVDLLVALDGDPAVMRFINGGRPTSREAVETRVLPRLLRDYPWGTRGYWAAEEKGGGFLGWFEFRPVEADSPAVVELGYRLNRSAWGRGYATEGSRALIDKGFTDLGVERVTANTMAVNAGSRRVMEKSGLTLVRHFTGDWPEQIEGSEHGEVEYALTRSGWERTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8X2</accession>
    <name>A0A0F7N8X2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Proteinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_14205</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016520.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH83192">
        <property type="protein sequence ID" value="AKH83192"/>
        <property type="gene ID" value="AA958_14205"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_14205"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2990"/>
    <dbReference type="OrthoDB" id="665798at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519870" evidence="1">
        <location>
            <begin position="31"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="119"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH83192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="529" mass="56444" checksum="01415DEB01A033D4" modified="2015-07-22" version="1">MDLRSLFRTAAPVTALAVLMAAAGCESAGSDDGGTGTAGADAERAGSVSKVLEPLPAQTPAELKPYYEQKLRWTECPTPGFDCATLRVPLDYAEPGGEDLELAVARKEAEDPGERLGSLHVNPGGPGASAIEFMQDFASIGYPADVRARYDIVAMDPRGVGSSQPVKCLTDKEFEAHTQVDQTPDDEGEVEALTASFDRFAQGCAKRAGDLLGHVSTEEAARDMDVFRGVLGDRKLTYVGASYGTMLGATYAGLFPQRAGRLVLDGAMDPSLTSRQLNLDQNAGFTTAFDSFAEDCVQRSDCPLGTGSAEEAGTQLRDFLDRLDAKPVPTGEQRALGEPLATMGVLMAMYQEDFWPQLRDSLADAMERKDGSGLLALADMYFEREPDGSYGSMMYGFAAVNCLDQPPPFETPADVEKLVPDFEADSPVFGRDFAWAALNCADWPVTATGEANRIEAAGTDPILVVGTTRDPATPYVWAESLAAQLKEGVLLTYEGDGHTAYARGNGCIDDAVGTYLLEGTPPQDGKRCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N910</accession>
    <name>A0A0F7N910_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_19515</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017296.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH84003">
        <property type="protein sequence ID" value="AKH84003"/>
        <property type="gene ID" value="AA958_19515"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_19515"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4111"/>
    <dbReference type="OrthoDB" id="1750764at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH84003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="112" mass="11786" checksum="B89387923467680C" modified="2015-07-22" version="1">MSTTVTDEQIRDLAATAKPYSVAVLHWGPERTMDGADAIELEHQRRMVSLRAEGVIAVLCPVASDTVAGVAIMTVPAGKASEIMAGDPCVRAGMMRCEVHPCHGFPGDALPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9A3</accession>
    <name>A0A0F7N9A3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_23085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017863.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_23085"/>
    <dbReference type="EnsemblBacteria" id="AKH84606">
        <property type="protein sequence ID" value="AKH84606"/>
        <property type="gene ID" value="AA958_23085"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_23085"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4865"/>
    <dbReference type="OrthoDB" id="1832160at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="195" mass="19614" checksum="DE2E528AF7D5F3B0" modified="2015-07-22" version="1">MSNPPSFRHAAVTPFSPLPDPAALTGFRDPAGTAAAPAGAGLTEPAAPPGPAGPAGAATPSGLADAPGPAEWSFPADPGCVRTARAVVRDTLRTWRLDPVTDLAVLLVSELVTNSLRYASGPVGLRLRPVGGPDACGGVRVEVSDTLPVPPLLRAAAPDEEGGRGLQLVASVAVRWGTRCGGMGKTVWFELGSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9G3</accession>
    <name>A0A0F7N9G3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4115 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_26470</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018424.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_26470"/>
    <dbReference type="EnsemblBacteria" id="AKH85185">
        <property type="protein sequence ID" value="AKH85185"/>
        <property type="gene ID" value="AA958_26470"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_26470"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5571"/>
    <dbReference type="OrthoDB" id="2071222at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025194">
        <property type="entry name" value="DUF4115"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13464">
        <property type="entry name" value="DUF4115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4115" evidence="3">
        <location>
            <begin position="193"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH85185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="270" mass="28407" checksum="F1F83716DEDD6A08" modified="2015-07-22" version="1">MSLGNSPTGDRPSVGRALQQARLDAKLSVEQVSLTTRVRIPIIHAIEQDDFSRCGGDVYARGHVRTLARAVGLEAEGLVAQYDAEHGGRPEPTPAAPMFEAERIRPEPRRPNWTAAMVAAIVAVVGFVGFTVFSGGDEDEPDGSSVAGETQGSEKPKDRDSGKDGAEDKQSPQPSDSAVAGAPPDKVTLRIVAADGQSWISAQGADGRELEEGVLAQGDSVTVTDSEKIYLVLGNAGGVDLFVNGKQIAEDFQPGEVERLTYTKGDPEAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9I6</accession>
    <name>A0A0F7N9I6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Asparagine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_20090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017394.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_20090"/>
    <dbReference type="EnsemblBacteria" id="AKH84104">
        <property type="protein sequence ID" value="AKH84104"/>
        <property type="gene ID" value="AA958_20090"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_20090"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4232"/>
    <dbReference type="OrthoDB" id="610569at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Asparagine synthetase" evidence="2">
        <location>
            <begin position="267"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH84104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="700" mass="72210" checksum="754D8BBD8B30E8D1" modified="2015-07-22" version="1">MRWLVGWSSAAAAPSFLDGAQSADDYDLHPVGAQLVWGGADPLWAVGDWRPDEIRVVDVAPLIRLAIFGTCGASDDQLRVGLLSARGGAVRHLTAWSGGYTAVAQVGRRTTVLGDLAGARPVFHAAWDGGTAYATAALPLADLIEAELDVSHLAAQLACPDVPEALGDGTPYAGVRRVPPGHALILREGAKEITGYEPRASLAVAAPSLDTEPAVAGVRDALVESVRARLAAPRHAPEPGYGGLDPGPVPGMGPADRRASRGPAPGIGADLSGGIASGTLALLAAGLPGVPGTPPGLGPGQGERLVAVTFNDLTARADEGELERARTIAANPRLHHVVVAAGEAALPYADLESMPLTDEPGPSLVAAARHRRRLTAGSADHLVGVGAREVLDAHPARLADLLLDRRRRSLFRPVTALARAEGSVLAPLTVYRAARRLARTTYWEGISEGADALLDDPAGGLGGAPGRSRGALDASLAALSWCRPGPAARWLTGEALAEVSVRLRGSAGTANGDGTGRPGERRAAAALAQLGADYRVFEQAAEVRFQRLHAPFLDNQVVRACRALPEALRVQPGARAAVLGAVLDGAGIRGLPPGWGATTGPAAAAASAERIGLRRASTELADLFHRPLLADAGLVEGRVVRKALRAAADGEPLPLGGLAELVSTELWLQRLLMRRGSCWTGDAAPRQRAVAGGVPPRLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9U9</accession>
    <name>A0A0F7N9U9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_20875</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017524.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH84239">
        <property type="protein sequence ID" value="AKH84239"/>
        <property type="gene ID" value="AA958_20875"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_20875"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4400"/>
    <dbReference type="OrthoDB" id="1926714at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="10"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="42"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH84239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="317" mass="34181" checksum="4B6A5FCDC47AC763" modified="2015-07-22" version="1">MTTTTDSPAIAATGLRKSYGDKTVLDGIDLHVPEGTVFSLLGPNGAGKTTAVKILSTLITADAGAIRVAGHDPATHADAVRAAIGVTGQFSAVDNLITGEENMRLMADLHHLPRAEGRRITAELLERFDLTDAAARPAATYSGGMRRRLDIAMTLVGSPRIIFLDEPTTGLDPRSRHDMWQIIRELLTDGVTVFLTTQYLEEADELADRIAVLHGGRIAAQGTAAELKRLVPGGHVRLRFEDPGAYERAAGELRETVRDDQALTLQIPSDGTQRELRAILDWLEAADVHADTLTVHTPDLDDVFFALTAAPEKEAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9Y2</accession>
    <name>A0A0F7N9Y2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HATPase_c domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_24435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018088.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_24435"/>
    <dbReference type="EnsemblBacteria" id="AKH84836">
        <property type="protein sequence ID" value="AKH84836"/>
        <property type="gene ID" value="AA958_24435"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_24435"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5149"/>
    <dbReference type="OrthoDB" id="1832160at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HATPase_c" evidence="1">
        <location>
            <begin position="29"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="152" mass="15777" checksum="67AAE90F62F81759" modified="2015-07-22" version="1">MASSSHTALGTTADFDVAAHGESFELVARAAAAAEARAHVRRLLGDWRLGGGDVCDAAQLVISELVTNAVLHASGGRIVCRLALRQPWVRLEVRDQGGAYGVPIRTVAGPEDECGRGLGLVAALSEAWGAEPSGPGFSVWATIRVPRPVRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9Z8</accession>
    <name>A0A0F7N9Z8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_16440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016837.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_16440"/>
    <dbReference type="EnsemblBacteria" id="AKH83532">
        <property type="protein sequence ID" value="AKH83532"/>
        <property type="gene ID" value="AA958_16440"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_16440"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3460"/>
    <dbReference type="OrthoDB" id="618655at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011975">
        <property type="entry name" value="PaaN_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02288">
        <property type="entry name" value="PaaN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="2">
        <location>
            <begin position="98"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH83532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="560" mass="59707" checksum="0F36C30740146BC4" modified="2015-07-22" version="1">MPAPLTPDALAEKHRPILDQALDAIRTRAFWSPHPEHPKAYGESAPADGQAAFEALRGTRIDLSQPGTDGWAGDEVSPFGLELGITYPHADPDVLLPVMRAATGAWRQAGPELRALVCLEILARISARTHEFAHAVMHTSGQAFMMAFQAGGPHAQDRGLEAVAYAYAEQSRTPLVAEWSKPQGKRDPLHLRKTFTAVPRGVALLVGCNTFPTWNGYPGLFASLATGNAVLVKPHPRAVLPLALTVQAAREVLAEAGFDPNLVCLTAERDGEGVAKSLALHPEIRIVDYTGSSAFGEWLEENARQAQVYTEKAGVNTVVVDSTNDYRGMLANLAFSLSLYSGQMCTTPQNLLIPRDGIDTDQGRKSYDEVVAGLAAAVDKLLGDDERAAALLGAIVNPGVRERLEAAPGLGEVALATRAVVHPEFPGATVRTPVIVKLDGAKPEAEAAYMEECFGPVSFAVAVDSTGDAVELLRRTIREKGAMTVGAYTTSTEVERQIEEACLEEPAQLSFNLTGGVYVNQTAAFSDFHGSGGNPAASAALTDGAFVANRFRMVEVRRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NA02</accession>
    <name>A0A0F7NA02_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Magnesium transporter CorA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_27520</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018594.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH85360">
        <property type="protein sequence ID" value="AKH85360"/>
        <property type="gene ID" value="AA958_27520"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_27520"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5799"/>
    <dbReference type="OrthoDB" id="822653at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="SSF143865"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="SSF144083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="304"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="335"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH85360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="361" mass="39954" checksum="3DB7E7F99846187B" modified="2015-07-22" version="1">MIKSLRHVVRRAPRRTVDLSHHARSPLGTAVVNCVSYLDGARLQQGNCPAAEALRQVRRRGHGFVWIGLHEPRQEEFAGLADLFGLHPLAVEDAVHAHQRPKVEQYDDTLFAVFKTARYVEHAELTATSEVVDTGELMVFAGPDFVITVRHGPHGSLGPLREALEAAPEQLAQGPAAVLHAIADHVVDDYLAVTDAVQRDIDDVETAVFSEHARSGDAGRIYQLKRELLELRRAVAPLDRPLQRLATRPMPHIAPGIRAYFRDVADHLQRITDQITSYDALLDSILQAHLAQVTVAQNEDMRKITAWAAIIAIPTMVCGVYGMNFDHMPGLESVYGYPATLLVIAVACSVVHRGFRRNGWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NA24</accession>
    <name>A0A0F7NA24_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_21425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017597.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_21425"/>
    <dbReference type="EnsemblBacteria" id="AKH84334">
        <property type="protein sequence ID" value="AKH84334"/>
        <property type="gene ID" value="AA958_21425"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_21425"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4511"/>
    <dbReference type="OrthoDB" id="975147at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="172" mass="18078" checksum="A6C17ED2EC72DB86" modified="2015-07-22" version="1">MAGLTAAALGVVAFLAYQANANAPDSLARSRPGVASPEPTKAKEKKLELPARSGSGLRVVYALKDKRVWLVGEDNSVLRTYKVTPSTVDPPPGMYTVTSRSRQITGSDGVPVEHVVIFTESEGTVIGFSAAVDGSRPEPDATEKTGGVRSSRVDGRALWRFATVGVPVAVVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NA42</accession>
    <name>A0A0F7NA42_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NTP pyrophosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_27825</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018644.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_27825"/>
    <dbReference type="EnsemblBacteria" id="AKH85410">
        <property type="protein sequence ID" value="AKH85410"/>
        <property type="gene ID" value="AA958_27825"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_27825"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5865"/>
    <dbReference type="OrthoDB" id="1469203at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH85410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="130" mass="13444" checksum="B329AD6E89AC9A49" modified="2015-07-22" version="1">MDAPLPLLVVDAANVVGSVPDGWWRDRHGAAERLRDGLVPYASAGVAGLPGPVEVVLVVEGAARGVAAVPGVRVVAADGSGDDRIVEVVAEAAERDPERRVLVVTADRALRDRVHRHGAATAGPRTVRPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAA9</accession>
    <name>A0A0F7NAA9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Methylmalonyl-CoA mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_21670</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017636.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_21670"/>
    <dbReference type="EnsemblBacteria" id="AKH84374">
        <property type="protein sequence ID" value="AKH84374"/>
        <property type="gene ID" value="AA958_21670"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_21670"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4564"/>
    <dbReference type="OrthoDB" id="1335734at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006159">
        <property type="entry name" value="Acid_CoA_mut_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="SSF52242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00640">
        <property type="entry name" value="acid_CoA_mut_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B12-binding" evidence="3">
        <location>
            <begin position="6"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH84374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="137" mass="14444" checksum="0D21848D2F754C45" modified="2015-07-22" version="1">MSGTGPIRVVVAKPGLDGHDRGAKVIARALRDAGMEVIYTGLHQTPEQIVDTAIQEDAEAIGLSILSGAHMTLFGKVVELLRERDALDIKLFGGGIIPEDDIPQLKGLGVAAIFTPGAATTEVVEWVRTHVREPAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAC0</accession>
    <name>A0A0F7NAC0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_22150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017709.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_22150"/>
    <dbReference type="EnsemblBacteria" id="AKH84448">
        <property type="protein sequence ID" value="AKH84448"/>
        <property type="gene ID" value="AA958_22150"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_22150"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4665"/>
    <dbReference type="OrthoDB" id="1505023at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019692">
        <property type="entry name" value="DUF2581"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10756">
        <property type="entry name" value="bPH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH84448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="227" mass="24025" checksum="5B0A030028C7526D" modified="2015-07-22" version="1">MSKDTPDTRPKYADRAYRSVSGIAAGVLLLVLGGWLGADALVRGSGQARAIAVAALVAGVPMVVSLTLRPVVYAGEERLRVRNPFRTIVVPWGRVEEIRAGYSSEVVTEDAKYQMWAIPVSLRARKKANRRRDRAAGGGGLFSPSSRPALSDPAMRRPGGTGAADLDPSGGDLTPTADKSIRELRELAHTYADREGAQGPVTVRWAYEILGPAIAGGLALIIVIAVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAC8</accession>
    <name>A0A0F7NAC8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cytokinin riboside 5'-monophosphate phosphoribohydrolase</fullName>
            <ecNumber evidence="1">3.2.2.n1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_25455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>9-ribosyl-trans-zeatin 5'-phosphate + H2O = D-ribose 5-phosphate + trans-zeatin</text>
            <dbReference type="Rhea" id="RHEA:48564"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16522"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:87947"/>
            <dbReference type="EC" id="3.2.2.n1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + N(6)-(dimethylallyl)adenosine 5'-phosphate = D-ribose 5-phosphate + N(6)-dimethylallyladenine</text>
            <dbReference type="Rhea" id="RHEA:48560"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17660"/>
            <dbReference type="ChEBI" id="CHEBI:57526"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="EC" id="3.2.2.n1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LOG family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.n1" evidence="1"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018257.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_25455"/>
    <dbReference type="EnsemblBacteria" id="AKH85006">
        <property type="protein sequence ID" value="AKH85006"/>
        <property type="gene ID" value="AA958_25455"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_25455"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5365"/>
    <dbReference type="OrthoDB" id="1255127at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102682">
        <property type="term" value="F:N6-(Delta2-isopentenyl)-adenosine 5'-monophosphate phosphoribohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009691">
        <property type="term" value="P:cytokinin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005269">
        <property type="entry name" value="LOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031100">
        <property type="entry name" value="LOG_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03641">
        <property type="entry name" value="Lysine_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00730">
        <property type="entry name" value="TIGR00730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0203">Cytokinin biosynthesis</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="178" mass="19395" checksum="27047AB06222A71B" modified="2015-07-22" version="1">MNICVFLSAADLDERYTAPARHFAELLGKRGHTLVWGGSDVGLMKVVADGVQEYGGRLVGVSVTFLADKARAGADEMVIARDLAERKAELLGRSDAVVIMVGGTGTLDEATEILELKKHGLHAKPVVLLNTAGYYDGLREQFRRMEAEGFLPLPLTELMFFADDPEAAMTYLEARPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAT7</accession>
    <name>A0A0F7NAT7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NADH-ubiquinone oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_18215</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017122.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_18215"/>
    <dbReference type="EnsemblBacteria" id="AKH83822">
        <property type="protein sequence ID" value="AKH83822"/>
        <property type="gene ID" value="AA958_18215"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_18215"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3830"/>
    <dbReference type="OrthoDB" id="1194694at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018931">
        <property type="entry name" value="DUF2520"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019665">
        <property type="entry name" value="OxRdtase/DH_put_Rossmann_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037108">
        <property type="entry name" value="TM1727-like_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10728">
        <property type="entry name" value="DUF2520"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10727">
        <property type="entry name" value="Rossmann-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="Rossmann-like" evidence="1">
        <location>
            <begin position="8"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2520" evidence="2">
        <location>
            <begin position="149"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH83822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="302" mass="30495" checksum="B5864A80DA67F020" modified="2015-07-22" version="1">MNPSPTPEPQEKPARLAVGVVGAGRVGPPLAAALALAGHRPVAVHAVSDGARRRVEELLPDVPVTEPAEVLARADLVLLTVPDDVLPGLVEGLAGTGAVRPGQLLVHTSGRYGAAVLEPATRAGGLPLALHPAMTFTGTAVDVQRLAGCSFGVTAPGELRMAAEALVVEMGGEPEWVEEAARPLYHAALAIGANHLVTLVAQSMELLARAGVGAPDRMLGPLLGAALDNALRSGDAALTGPVARGDAGTVAAHIAELRVHAPQAVPAYVAMARATADRALAGGLLKPELAEDLLGVLSDGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAW6</accession>
    <name>A0A0F7NAW6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_26755</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018473.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_26755"/>
    <dbReference type="EnsemblBacteria" id="AKH85236">
        <property type="protein sequence ID" value="AKH85236"/>
        <property type="gene ID" value="AA958_26755"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_26755"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5629"/>
    <dbReference type="OrthoDB" id="1833499at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="388"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="428"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="469"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="514"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="544"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="603"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="288"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="311"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH85236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="650" mass="66905" checksum="C3D416C1C3A61D35" modified="2015-07-22" version="1">MIQAIGLTSRPRGGRPPAVRDLTFEAEEGTVTALLGEPGAGKTAALRLMLQLDSGRGIALYDGRPLSRLPAPAREVGAVLGDVAGHPARTVLSHLRMLAAAVGVPAARADALLTHVGLDALADDRLDALSLSMDRRLGLATALLGQPHSLLLDDPVRDLPRREAAFYYALLRELAAAGVCVVLATDQPRVAARFADRVLTLRAGRLVADEEADDFARLRLRPCVLIRTPQSERFASYLTRQASTPERRIEVVRRDGGALAVYGTDSAAVGELAYRNGILLHQLTDSSHESVPTAVPEPGAPEAVTPEATAPAATRTATATLEPGTDTETHAGPPRADGDTPPAGTFIPAPVAGPDDAPLAGPLRRRWLPGPAYPLRYELRRATSGSRLPRVAAAGTLAASIAGAALLAHSAGGSAVSDAPAVRMLTGWAPFLPLPPAAIGAGLLGAHAFGQEFSFPSLTPAVGAVPRRLGLLFAKLAVSTAVALLLFVAVLLADATALLVLFGDVVDMPADGGLQLLSWAGVTVGCAWTGVLAAGLFTSASLGLAAVLTVPVAVAPGIHALAGTGAVRRLGELPVQLMRVLHIPRPGGGPNLGGVFGVPAQPFGHALVLSLGALLGAYVLTAGRARSLGRALERSGCPSFVRRVFNSPGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NB82</accession>
    <name>A0A0F7NB82_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Anti-sigma regulatory factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_23730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_027753975.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_23730"/>
    <dbReference type="EnsemblBacteria" id="AKH84719">
        <property type="protein sequence ID" value="AKH84719"/>
        <property type="gene ID" value="AA958_23730"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_23730"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5001"/>
    <dbReference type="OrthoDB" id="1832160at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH84719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="137" mass="14403" checksum="2C674CFAA49AF54C" modified="2015-07-22" version="1">MSQFEGEPSPKDFVEVRLPAAGAYLSVLRTATAGLAARLDFTLDEIEDLRIAVDEACAILLQQAVPGSVLTCVFQLGDDALLVTVSAPTTDGRAPERDTFAWTVLSALAGRVDATVGDDRTVTISLLKERGAAPGLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBA3</accession>
    <name>A0A0F7NBA3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_27645</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018615.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH85381">
        <property type="protein sequence ID" value="AKH85381"/>
        <property type="gene ID" value="AA958_27645"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_27645"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5825"/>
    <dbReference type="OrthoDB" id="827157at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH85381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="71" mass="7777" checksum="D97EA6E0B7A3E2A1" modified="2015-07-22" version="1">MHPESEALIEQETREAFTGVDGKRPAAWQLAWALQDQVRLFQTRASHSDDVTDVALANLRLASRTGAALSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBC1</accession>
    <name>A0A0F7NBC1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_23990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018016.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_23990"/>
    <dbReference type="EnsemblBacteria" id="AKH84764">
        <property type="protein sequence ID" value="AKH84764"/>
        <property type="gene ID" value="AA958_23990"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_23990"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5056"/>
    <dbReference type="OrthoDB" id="1361074at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abhydrolase_3" evidence="1">
        <location>
            <begin position="91"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="328" mass="35119" checksum="75F1D5E640446FE0" modified="2015-07-22" version="1">MSENRKPAAYTPAAPVLEPAAAAFAGATANPPYLFDLGPAEGRKTVDEVQSGEIEKPEVAEEWVTVQGGPTGSVRTRIVRPADAAGALPVILYLHGAGWVFGNAHTHDRLVRELAVGARAAVVFPEYDLSPEARYPVAIEQNYAVARWIVTDGAGSGLDPARIAVAGDSVGGNMSAALTLQAKERGDVPLVQQVLFYPVTDASFDTGSYRRFAEGYFLRRDAMQWFWDQYTTDEAQRAEITASPLRASTEQLAGLPPALVITAEADVLRDEGEAYANKLRQAGVPVTAARYQGVIHDFVMLNALRETHAADAAIGQAVAVLRRAFGTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBD4</accession>
    <name>A0A0F7NBD4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Flavoprotein oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_27885</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018655.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_27885"/>
    <dbReference type="EnsemblBacteria" id="AKH85421">
        <property type="protein sequence ID" value="AKH85421"/>
        <property type="gene ID" value="AA958_27885"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_27885"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5878"/>
    <dbReference type="OrthoDB" id="1149616at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="3">
        <location>
            <begin position="6"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_dim" evidence="2">
        <location>
            <begin position="341"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH85421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="468" mass="49795" checksum="7D6ECDA0B0858A68" modified="2015-07-22" version="1">MGAKQRMVVIGGDAAGMSAASQARRMRTPDELEITAFERGRFTSYSACGIPYWVGGEVPERDQLIARTPEEHRARGIDLRMRTEVTEIDLDRQCVRTRALDEEAGAQERWHGFDHLVIATGARPLRPPLPGIDAPGVHGVQSLDDGQELLDRLEKQQVRHAVVVGAGYIGVEMAEAFCHRGIHVTVLERAEQPMNTLDPDMGGLVHEAMNGNGIGIVTGAEVTEILTGTDGEVRGVATANGEYPADVVVLGLGVRPETGLARDAGLPLGESGGLLTDLAMRVRGQENVWAGGDCVEVLDLVSGRERYIPLGTHANKHGQVIGRNVGGGFGTFPGVVGTAVSKVCDLEIARTGLLEAQAREVGLQYVTVTIRSTSRAGYYPRAALMHVKMLAERRTGRLLGVQIVGREGAGKRVDIAAVALTAGMTVEQMTALDLGYAPPFSPVWDPVLVAARKAAAAVAEDARETDGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBH3</accession>
    <name>A0A0F7NBH3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransf_11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_24335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018071.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH84819">
        <property type="protein sequence ID" value="AKH84819"/>
        <property type="gene ID" value="AA958_24335"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_24335"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5128"/>
    <dbReference type="OrthoDB" id="1099537at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="354"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="510" mass="54776" checksum="3F26286D435AF0A9" modified="2015-07-22" version="1">MSASAAPAKVHELVSAFVDAPDDRLDAEFRQLTGALWRDGAATGLALPAAEELAGRFEALDDRRRGYAAVLLGLLVETEYPATDGPVATAVGTGLDAYADLAGGLDQGDPLFLALCYLLAHFPAARERVLAAARQAGLHEDDYSRLDRALATLDPEHPVLGRVFPSPAAWQRYGAEGDFDKRWIEAMSPEEVVRGWRADTGTAFAGLGAKAYWAVRNWTSPAVPAEIEFPPAEQVVRAAEPAVNLFDAHEPALRCPACGGAFHVAARRARCTECDTAYPVSAGILDLTKTMAGDEADDFDFMVAETPGMTLFYERIARPNFLRLCGSNWDDAVTTGIEDDYLARHVRPVEGPVLDLGCGAGRWTGVLADTVGAERVVALDATGPMLSMLRARLPGVPAIRSGAAPLPFKDASLGAVLCWNALQAFPDPPAAVAEVGRCLRPGGTFTVMTFRNSDDPVYRHFVAAHTPAEYRVGPRPFDPDTLKELLADAGLRIREEWGPGTFVFFTAERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBJ0</accession>
    <name>A0A0F7NBJ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydroxydechloroatrazine ethylaminohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_28430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018750.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_28430"/>
    <dbReference type="EnsemblBacteria" id="AKH85516">
        <property type="protein sequence ID" value="AKH85516"/>
        <property type="gene ID" value="AA958_28430"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_28430"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5991"/>
    <dbReference type="OrthoDB" id="1592010at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="1">
        <location>
            <begin position="61"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="458" mass="47891" checksum="D473CCCB16114D09" modified="2015-07-22" version="1">MAARRTVVENCAIATVDAAGTEYASGHVVVADNRIESVGAGPAPAGLAGVARRIDAAGHLATPGLVNTHHHFYQWLTRGLAQDANLFDWLVALYPTWARIDEPMCHAAAQGSLAVLARGGVTTAMDHHYVYPRGAGDLSGAIIRAARETGLRFTFARGSMDLGETAGGLPPDFAVETLDGALAGTEAVIDAHHDASYDAMVQVAAAPCSPFSISTELLREGAELGRRKGVRLHTHGSETVEEEKFCHERFGMGPTAYFESTGWLGDDVWMAHCVHMTDADIAAFARTRTGVAHCPSSNARLAAGIARVPDMLAAGVPVGLGVDGSASNESGELHTELRNALLINRLGAHREKALTARQALRLATYGGAQVLGREDAIGSLEPGKLADLVLWKLDGLAHASIADPVAALVLGAPAPVTLSLADGKPVVEEGRLVTVDEEAVAAKTREEAGRLARLASGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBM1</accession>
    <name>A0A0F7NBM1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_20155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_20155"/>
    <dbReference type="EnsemblBacteria" id="AKH84112">
        <property type="protein sequence ID" value="AKH84112"/>
        <property type="gene ID" value="AA958_20155"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_20155"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4244"/>
    <dbReference type="OrthoDB" id="2076478at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010093">
        <property type="entry name" value="SinI_DNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01764">
        <property type="entry name" value="excise"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_17" evidence="1">
        <location>
            <begin position="24"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="80" mass="8926" checksum="EB8A6D284A6CC719" modified="2015-07-22" version="1">MSVMCGRFRCVMAASDKPLNEVVFLTVAEVAAVMRVSKMTVYRLVHSGHLPAIRVGRSFRVPEQAVHEYLRESYVGVESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBN4</accession>
    <name>A0A0F7NBN4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_24555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_24555"/>
    <dbReference type="EnsemblBacteria" id="AKH84853">
        <property type="protein sequence ID" value="AKH84853"/>
        <property type="gene ID" value="AA958_24555"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_24555"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5173"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006764">
        <property type="entry name" value="SAM_dep_MeTrfase_SAV2177_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04672">
        <property type="entry name" value="Methyltransf_19"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="163" mass="17413" checksum="DD7C4421FC1DD8AA" modified="2015-07-22" version="1">MRNHLLGGEDDHEADRAAAAALLAVFPGMAGIKRHSRQFTGRAVGHLVRDAGIGQFPDVGSELPTADNTHEIAQRTAPEARIVYADNDPLSPPGRPGLRRSPPPGQPGAAVPYTPRTPHEVERYFEGLHLLPPGVVSCPRWRPESTAEGLPEVAVYGGAARKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBT2</accession>
    <name>A0A0F7NBT2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sodium:proton antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_20495</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017460.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_20495"/>
    <dbReference type="EnsemblBacteria" id="AKH84172">
        <property type="protein sequence ID" value="AKH84172"/>
        <property type="gene ID" value="AA958_20495"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_20495"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4319"/>
    <dbReference type="OrthoDB" id="781228at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001991">
        <property type="entry name" value="Na-dicarboxylate_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036458">
        <property type="entry name" value="Na:dicarbo_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42865">
        <property type="entry name" value="PTHR42865"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00375">
        <property type="entry name" value="SDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118215">
        <property type="entry name" value="SSF118215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="92"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="200"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="343"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="429"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="436"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH84172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="450" mass="47594" checksum="4DB2DAF5928A3B5E" modified="2015-07-22" version="1">MSTPTPAPTAQPRSGFRIPKVPFWAQILAGLVLGVLLGWAARTGDVAWLKDTLDQIGTIFVQLLKLAVAPLVFFAILVSITNLRNVNNAARLATRTLLWFFATSLIAVAIGLAIGLLTNPGAGTDLSPKDGAAPEDSGSWIDFLTGIIPTDVITPFTELNVLQIVFMAAALGVAALKLGEKAQPIIAFSETILELLQKALWWVIRLAPLGTVGLIGFAIADYGWNLISKYATFTADVYIGCALVLFGVYPLLLATVAKVSPLQFFRGAWPAIQLAFVSRSSVGTMPVTKKVTERLGVPKEYTSFAVPFGATTKMDGCAAIYPALAAIFIAEIFDVSLGLQDYILIAFVSVIGSAATAGLTGATIMTTLTLSTLGLPLEGVGLLLAIDPILDMVRTATNVAGQAVIPVLVASQEKILDRDMYEYATSFDLDDPDPVDSQQPAQSPAVTVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBW9</accession>
    <name>A0A0F7NBW9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_25020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_25020"/>
    <dbReference type="EnsemblBacteria" id="AKH84928">
        <property type="protein sequence ID" value="AKH84928"/>
        <property type="gene ID" value="AA958_25020"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_25020"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5273"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002838">
        <property type="entry name" value="AIM24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036983">
        <property type="entry name" value="AIM24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016031">
        <property type="entry name" value="Trp_RNA-bd_attenuator-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01987">
        <property type="entry name" value="AIM24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51219">
        <property type="entry name" value="SSF51219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH84928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="202" mass="20847" checksum="3A1F9DDFA20FC7C7" modified="2015-07-22" version="1">MLAVDMAGDAVKAKNGSMVAYDGQMAFKKLTGGGEGIRGMVTRRLTGESMELMEVKGQGTCYFADRASVINLVGLQADKLYVESSNLLATDGGLKTGTSFTGMRGASTGTGLFTTTVEGTGQAAIMSDGPAVVLRVTPGTPLVVDPGAYVAHTGHVQQHFQSGATFRTLIGEGGGEGFQIRFEGDGLVYVQPSERNTVGGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NC22</accession>
    <name>A0A0F7NC22_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sulfatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_31765</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="PTM">
        <text evidence="3">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019263.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_31765"/>
    <dbReference type="EnsemblBacteria" id="AKH86035">
        <property type="protein sequence ID" value="AKH86035"/>
        <property type="gene ID" value="AA958_31765"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_31765"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6707"/>
    <dbReference type="OrthoDB" id="1067869at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase" evidence="4">
        <location>
            <begin position="8"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="3">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600917-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH86035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="506" mass="56793" checksum="31D5BD1BF59EBF41" modified="2015-07-22" version="1">MTQPARRPHILLITSDQQHWNTLGRGNPEIRTPHLDRLAAQGTAFERAYCPNPTCTPTRASMITGKYPSQHGAWTLGTKLPEDQPTLGQHLGAAGYATSLVGKAHFQPLASTAEHPSIESYPLLQDLGFWRDFHGPYYGFDHVELARNHTAEAHAGQHYALWLEQRGCADWRRYFRPPTGTLDPGVRHTWPIPEELHYNAWIAERTGALLEGYAERDESFFCWASFFDPHPPYLVPEPWDRMYDPDALTVPEAVAGEHDGNPPHFGLTQQDRPDFSPWQESGQYVHGFHSHLLPAAERRRLVATYYGMVSMLDAYVGRILDRLDALGLAEDTLVVFTTDHGHFFGQHGLQAKGAFHYEDLLRVPFLVRLPGRVPAGRASSALVSTVDLAPTFLELAGLPVPREMTGVSQAEVFTGGAPSARDHVICEFRHEPTAVSLRTYVDDRHKLTVYQGRTYGELFDLRADPGETRNLWDDPGSAGLKSELLLRYIWAELGKEPMWMPRVAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCN8</accession>
    <name>A0A0F7NCN8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Diaminopimelate decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_33065</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Orn/Lys/Arg decarboxylase class-II family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019477.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_33065"/>
    <dbReference type="EnsemblBacteria" id="AKH86250">
        <property type="protein sequence ID" value="AKH86250"/>
        <property type="gene ID" value="AA958_33065"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_33065"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6985"/>
    <dbReference type="OrthoDB" id="861683at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006596">
        <property type="term" value="P:polyamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022643">
        <property type="entry name" value="De-COase2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022644">
        <property type="entry name" value="De-COase2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000183">
        <property type="entry name" value="Orn/DAP/Arg_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002433">
        <property type="entry name" value="Orn_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02784">
        <property type="entry name" value="Orn_Arg_deC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00278">
        <property type="entry name" value="Orn_DAP_Arg_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01179">
        <property type="entry name" value="ODADCRBXLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01182">
        <property type="entry name" value="ORNDCRBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="SSF50621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orn_Arg_deC_N" evidence="4">
        <location>
            <begin position="28"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="Orn_DAP_Arg_deC" evidence="3">
        <location>
            <begin position="281"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="311"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH86250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="405" mass="41486" checksum="925DE63098273AD7" modified="2015-07-22" version="1">MTAPTPAVLARLGALAPGELPAYLYDLAALRAHAAAVRAALPASVELYYAAKANPEPAVLAALAPYVDGYEVSSGGELAHVAAVPGRRLAFGAPGKTPGELAAARAAGVHRVHVESLHELRVLGTLTADAPPDAGTDVLLRVNLPVADGSLAGSALAMGGRPSPFGLDPADAEEAARLLAGGAYPGLRLRGVHAHLASGLDAPRLLGVARSVVAGALRLAGRAGLGAQGLEVNVGGGMAVDYADPGGRFDWRAYGDGLAALVAAHPGLTLRVEPGRALTAYCGWYVTEVLDVKRSHGEEFAVVRGGTHHLRTPAAKGHDQPCTVHSSPRPWPHPWPRPAARGAEVTVAGQLCTPKDVLARGVPAAGLRAGDLVVFSLAGAYAWNISHHGFLMHPHPGFHFLDGPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCU2</accession>
    <name>A0A0F7NCU2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fumarate hydratase class II</fullName>
            <shortName evidence="2">Fumarase C</shortName>
            <ecNumber evidence="2">4.2.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Aerobic fumarase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Iron-independent fumarase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">aspA</name>
        <name evidence="2" type="synonym">fumC</name>
        <name evidence="6" type="ORF">AA958_22655</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>(S)-malate = fumarate + H2O</text>
            <dbReference type="Rhea" id="RHEA:12460"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="EC" id="4.2.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; tricarboxylic acid cycle; (S)-malate from fumarate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="2">There are 2 substrate-binding sites: the catalytic A site, and the non-catalytic B site that may play a role in the transfer of substrate or product between the active site and the solvent. Alternatively, the B site may bind allosteric effectors.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.2" evidence="2"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017795.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_22655"/>
    <dbReference type="EnsemblBacteria" id="AKH84537">
        <property type="protein sequence ID" value="AKH84537"/>
        <property type="gene ID" value="AA958_22655"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_22655"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4766"/>
    <dbReference type="OrthoDB" id="734949at2"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER01007"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045239">
        <property type="term" value="C:tricarboxylic acid cycle enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004333">
        <property type="term" value="F:fumarate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006106">
        <property type="term" value="P:fumarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00743">
        <property type="entry name" value="FumaraseC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005677">
        <property type="entry name" value="Fum_hydII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018951">
        <property type="entry name" value="Fumarase_C_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11444">
        <property type="entry name" value="PTHR11444"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10415">
        <property type="entry name" value="FumaraseC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Lyase_1" evidence="4">
        <location>
            <begin position="26"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="FumaraseC_C" evidence="5">
        <location>
            <begin position="419"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="112"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding (B site)" evidence="2">
        <location>
            <begin position="140"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="150"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="335"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="2">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="329"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="2">
        <location>
            <position position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH84537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="478" mass="50016" checksum="686F7832DC4C814E" modified="2015-07-22" version="1">MSQPADRSPAERPASDGFRIEHDSMGEVRVPAAAKWRAQTQRAVENFPVSGLRLESAHIAALARIKAAAAKVNAELGVLDEDVAAAVQAAAEEVAAGRWDDQFPVDVFQTGSGTSSNMNMNEVLATLAQEKLGAGGPVVHPNDHVNASQSSNDTFPSSIHIAATGAVVQDLIPALTHLQAALAGKAGEFAEVVKSGRTHLMDATPVTLGQEFAGYAAQVAFGVERLHASLPRLAELPLGGTAVGTGINTPPGFAAAVIAEVARATGLPLTEARDHFEAQGARDGLVETSGQLRTIAVGLTKICNDLRWMGSGPRTGLAEIALPDLQPGSSIMPGKVNPVVPEAVLMVCAQVVGNDVTVTTAGASGNFELNVMLPVLARNVLESVRLLANAARLLADRTVDGITAHAGRAREYAESSPSVVTPLNRYIGYEEAAKVAKKSLAERKTIREVVLEGGYVERGLLTEEQLDGALDVLRMTRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7ND31</accession>
    <name>A0A0F7ND31_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_27105</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018528.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH85293">
        <property type="protein sequence ID" value="AKH85293"/>
        <property type="gene ID" value="AA958_27105"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_27105"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5710"/>
    <dbReference type="OrthoDB" id="1194802at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015299">
        <property type="term" value="F:solute:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006812">
        <property type="term" value="P:cation transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="221"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="296"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="331"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="359"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="Na_H_Exchanger" evidence="6">
        <location>
            <begin position="10"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="396"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="400"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH85293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="418" mass="43630" checksum="512FFB55E669D228" modified="2015-07-22" version="1">MVLIAVFGVALLVAVLLSGLAARSVLSTSLLFLVGGALVSDGFLGLIHITPDSDLVAVTADLALFAVLFTDGMHVSFPALRSAWKNPARALALGMPLAFVGMALVTHFVVGLDWTTSFLVGAVLAPTDPVFASAIVSRKEVPARLRQLLNVESGINDGLALPVVLILIAAAGPAGHGAEADLGKIGLELAGGLALGVAAPLVVYWLVRFRLLGAEPKLQPLLPLAVGIILYAVCHLTHSNPYLAAFSAGAVLASLSPEAKDAFEPLGESLAELAKFAALLVFGALLTPELFGDLSWGGYVAVVLAIVLIRPASLLLSLLGTRFDRRERLTAAWFGPKGFASVVYGLLVLQAQVPQGEEAFTLIAVCIAFSIVAHSSTDVPIARMFDVEDLVGLPNETDRAAGHDLPKQRQPGPDRARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7ND72</accession>
    <name>A0A0F7ND72_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MIP family channel protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_32595</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019403.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86176">
        <property type="protein sequence ID" value="AKH86176"/>
        <property type="gene ID" value="AA958_32595"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_32595"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6883"/>
    <dbReference type="OrthoDB" id="1744995at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015267">
        <property type="term" value="F:channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00333">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022357">
        <property type="entry name" value="MIP_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="SSF81338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00861">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00221">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="197"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="252"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH86176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="295" mass="31668" checksum="CA6F7ED541983DA0" modified="2015-07-22" version="1">MAERIVRRRGYREGLGGEMAAEFLGTFVLVLLGVGSVAVAVAGLPGSGRQTGDFGPANWLIISWGWGLAVVFGVYVAGGISGAHINPAVTLGFAARRDFPWRKVLPYWLAQIMGAFVAAALIYATYRWAIDAAIEKEGVPRDESLPTFSIFATFPAEYFGDSWWGPLLDQIVGTGILLLLICALIDRRNTAPMSNLHPFLIGLVVVAIGLSFGTNAGYAINPARDLGPRLLTYFEGWGSIALPGTFEWFSGYWWIPLVGPLIGGLVGVGVYDLLISPLIKARGVEPEEGPATEEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDP5</accession>
    <name>A0A0F7NDP5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">M20_dimer domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_28680</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018793.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_28680"/>
    <dbReference type="EnsemblBacteria" id="AKH85559">
        <property type="protein sequence ID" value="AKH85559"/>
        <property type="gene ID" value="AA958_28680"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_28680"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6044"/>
    <dbReference type="OrthoDB" id="906744at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00758">
        <property type="entry name" value="ARGE_DAPE_CPG2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00759">
        <property type="entry name" value="ARGE_DAPE_CPG2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="2">
        <location>
            <begin position="209"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH85559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="455" mass="48009" checksum="FE9D5F1049891816" modified="2015-07-22" version="1">MADATPHAPAAPHPGPDDAALDEVVGFTSDLIRIDTTNHGGGDGVERQAAEYVAERLAGAGIEPALLEKAPDRTNVVARIEGTDPGADALLVHGHLDVVPAEPADWSVHPFSGEIRDGVVWGRGAIDMKNMDAMVLAVVRAWARAGVRPRRDIVLAFTADEEASAEYGSGYLAEEHAALFDGCTEGISESGAFTFHAGNGLRLYPVAAGERGTAWLRLTARGRAGHGSKVNADNAVSRLAAAVGRIGEHRWAVRLTPTVRAALVETAAAYGVEVAPGELDDPAFDVDALLGKLGPAAALVAPTVRNSSNPTVLEAGYKVNVIPGSATAQIDGRMVAGGEEEFARTLDELTGPYVDWEFSHREVPLTAPVDAPLYAAMRASLERFDPGAHVVPYCMSGGTDAKQFSRLGITGYGFSPLKLPAGFDYQELFHGVDERVPVDALHFGVRVLDDFLRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDZ0</accession>
    <name>A0A0F7NDZ0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Homoserine kinase</fullName>
            <shortName evidence="11">HK</shortName>
            <shortName evidence="11">HSK</shortName>
            <ecNumber evidence="4 11">2.7.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">thrB</name>
        <name evidence="14" type="ORF">AA958_24795</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>ATP + L-homoserine = ADP + H(+) + O-phospho-L-homoserine</text>
            <dbReference type="Rhea" id="RHEA:13985"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57590"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.39"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the GHMP kinase family. Homoserine kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.39" evidence="4 11"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018139.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_24795"/>
    <dbReference type="EnsemblBacteria" id="AKH84887">
        <property type="protein sequence ID" value="AKH84887"/>
        <property type="gene ID" value="AA958_24795"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_24795"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5227"/>
    <dbReference type="OrthoDB" id="610857at2"/>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00064"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004413">
        <property type="term" value="F:homoserine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00384">
        <property type="entry name" value="Homoser_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006203">
        <property type="entry name" value="GHMP_knse_ATP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000870">
        <property type="entry name" value="Homoserine_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000676">
        <property type="entry name" value="Homoser_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="SSF55060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00191">
        <property type="entry name" value="thrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00627">
        <property type="entry name" value="GHMP_KINASES_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0791">Threonine biosynthesis</keyword>
    <keyword evidence="6 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP_kinases_N" evidence="12">
        <location>
            <begin position="88"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP_kinases_C" evidence="13">
        <location>
            <begin position="248"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="95"/>
            <end position="105"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AKH84887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="323" mass="32754" checksum="F0B29A2D7C904490" modified="2015-07-22" version="1">MAGPAFRAAPVRVRVPATSANLGPGFDTFGLALGLYDDVVVRVAESGLHVDIAGEGAENLPRDESHLLVRAMRSAFEALGGQPRGLEVVCANRIPHGRGLGSSAAAICAGIIAARAVTIGGAERSGVLDAPERAALLELATELEGHPDNVAACLLGGFTLAWTDDGTGGAGTAPGDAPAAVRAIRLEPAGGVVPVVFVPGNPLSTAEARGLLPRTVPHADAALTAARAALFVEALTRRPELLLTATEDRLHQDYRAPAMPESTALVARLRADGVPAVISGAGPTVLAFAEDGAAEKVARSAGEGWAANRLALDREGASVLPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDZ4</accession>
    <name>A0A0F7NDZ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AA958_29420</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018908.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_29420"/>
    <dbReference type="EnsemblBacteria" id="AKH85679">
        <property type="protein sequence ID" value="AKH85679"/>
        <property type="gene ID" value="AA958_29420"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_29420"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6208"/>
    <dbReference type="OrthoDB" id="760677at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="6"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="119"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="221"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH85679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="387" mass="42113" checksum="A61C8BF1F0CBBBB0" modified="2015-07-22" version="1">MTTTSDILERARAFAHHELVGQEKYLDSFDTAPLPLYKTFHEQDLSNWWIAPQHGGRGLTLEDSVDIVSELAYGDAGAAFTLFISILGTTMVQLYGSEELQARYLGAMARTGGFCATLGSEEAAGSELARITTTIARDGVDLAINGTKYFSTNTGFADFLIVVGRSADDPSDFIAALVPAGTPGVHITKRWEMIGLRSSGTYEVSLIDCRVPAANVLRGPGLRLLEVGLNASRILIATTALGVARRIRDISMDYAEDKTLQDGYLIDHPVFMNRLGKMETQIDVMKNQCRAAAREFDTLMARPDAADALVQRGTLRSALAAKMYCGQAGWEIASAGSEMFGGLGFTTDHIIGKLLRDIRYVSIVEGGDPVLQELMFNRYVLPEPKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NEE5</accession>
    <name>A0A0F7NEE5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dihydroxyacetone kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_25800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018311.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_25800"/>
    <dbReference type="EnsemblBacteria" id="AKH85067">
        <property type="protein sequence ID" value="AKH85067"/>
        <property type="gene ID" value="AA958_25800"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_25800"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5434"/>
    <dbReference type="OrthoDB" id="1554133at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004371">
        <property type="term" value="F:glycerone kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019986">
        <property type="entry name" value="DAK2_dom-cont_prot_YloV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004007">
        <property type="entry name" value="DhaL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036117">
        <property type="entry name" value="DhaL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033470">
        <property type="entry name" value="UPF_DhaK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13684">
        <property type="entry name" value="Dak1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02734">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01121">
        <property type="entry name" value="Dak1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01120">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101473">
        <property type="entry name" value="SSF101473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03599">
        <property type="entry name" value="YloV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51480">
        <property type="entry name" value="DHAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DhaL" evidence="2">
        <location>
            <begin position="5"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH85067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="567" mass="55768" checksum="C3E26D88CDED94B2" modified="2015-07-22" version="1">MLDASSVRAWCALALEALGRGREEIDAVNVFPVADGDTGTNLYLTVESAAQAVDAVYGAFAAETAGSGGGGVEPAVADVLRAMAHGALIGARGNSGTILAELLRGLTGAVVAADAGSGTGSGPGSGALLAGALRRGADAARAAVEHPVEGTMLTVADAAAAAAEGSGAGDAARVARAAYDGAREALAATTGQLDVLRRAGVVDAGGLGLVAVLGTLADALSGAARPTELELEGPAGRGAGSRRTTARHEGGDAACPVPAGGGPGYEVIYLLEAADDAVARLRPRLDALGDSLVVVGGDGLWRVHVHVDDAGAAVEAGVEAGRPYRIRITHLPAGTAAPPRGGAGGGPGGRAVVAVVPGEGLAALCAEAGAGVVTVREGEPPASGELAEAMRRTGAREVVLLPNDAELRHTAAVAVEEARASGVRAALIPTRAAVQGLAALAVHDPGRRFDEDVVAMTAAAGATRHAELAVAEQEAWTTAGICRPGDVLGVMEGDVAVVGADLAGTAEAVLDRMLAGGGELVTLVLGPDLPRGFGARLEAHVRSGHLAVDTVVYEGGSQSAPLLIGVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NEP4</accession>
    <name>A0A0F7NEP4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Damage-inducible protein CinA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_26485</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018426.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_26485"/>
    <dbReference type="EnsemblBacteria" id="AKH85187">
        <property type="protein sequence ID" value="AKH85187"/>
        <property type="gene ID" value="AA958_26485"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_26485"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5574"/>
    <dbReference type="OrthoDB" id="1834406at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036653">
        <property type="entry name" value="CinA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008136">
        <property type="entry name" value="CinA_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02464">
        <property type="entry name" value="CinA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142433">
        <property type="entry name" value="SSF142433"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00199">
        <property type="entry name" value="PncC_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CinA" evidence="2">
        <location>
            <begin position="13"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH85187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="188" mass="19396" checksum="99672C72F11FBF8E" modified="2015-07-22" version="1">MTTQNTDGAAAGLLALCEERGVTLAVAESLTGGLLAAEITAVPGASQAFRGAVIAYATDLKRDVLGVDSSLLAQRGAVDGEVARQMAAGVRWRLGADWAVATTGVAGPDPQDGQQPGTVFVAVAGPEGRTETRSLNLTGSRTEIRTAAVGEALTLLRRHLDAAPKGQDGRKYPENPDQEAPYSSLGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NET0</accession>
    <name>A0A0F7NET0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_30595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019071.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH85843">
        <property type="protein sequence ID" value="AKH85843"/>
        <property type="gene ID" value="AA958_30595"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_30595"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6466"/>
    <dbReference type="OrthoDB" id="226976at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="594"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="602"/>
            <end position="632"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="632" mass="69365" checksum="083D5560619CDD19" modified="2015-07-22" version="1">MSTELRDRFFALSTAAGRAPAEEVDRYRTLVDATDAEPAAVLDGLAVSWHPTARFKAVRFVDAERIDAGVRDLFARPSEAAPYLAAVFADPREMSFRTYENILPLDRLFADAGLEFELTDRTEFAEGAYSFSIGLPAAARARLAGLDGLDLYVPPLNSGSRGGDRFIFHSALLAEALTKAVTEALPRTRLDGFAHVNPVFRCNRFEPDDANFHRHRDTPYYDRSRGHVSRYTVLLYLTGGTGSPALDLTGGAALTDIAPFTCVIFDQRYEHEGAPYLEGRKVFLRTELVFTAPDAAHDPEIGALFAKACYLTGESVFAPELARYADDYYNRVAAAHWSGDLGAGAAGEPFLHKRFRGLDFVANGHDFWFPASGDLSPAACAAITLLDYFNCKVGDEAFRAACETTVVEAEGTDWIPAFLEESGGTSPVAPFDKSMLFPEPEQPATEDMPDCACGICDGGLLGPHFDTSRNADVIGHYVRAQDAAKAEVLPAPVMMLGEDVVLDPDRFVVEGNRIHVLGGKAPEPVNFASCQGGPPVPPAEDFVTTAATVDVAHFLVPPILFTEHDGLFHLKFDFFRNSWTVDHEQSTVAVPMVRPFSEDDIDENWEDHYYEDEDEDEDEEEGEGEEEAEDKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NEX0</accession>
    <name>A0A0F7NEX0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GCN5 family acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_31530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019227.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH85999">
        <property type="protein sequence ID" value="AKH85999"/>
        <property type="gene ID" value="AA958_31530"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_31530"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6660"/>
    <dbReference type="OrthoDB" id="1526822at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="171" mass="18148" checksum="672C018909F2AA8E" modified="2015-07-22" version="1">MTTHDEKPALRPARPGDAAAVARLWESAWRDAHLGHVSEALVAMRTPESFAARAAARVPETAVAEVGGEIAGFVTAAGDEVEQLFVAAEHRGSGVAALLLAEGERRVAARGYDRAWLAVVTGNARARRFYARQGWTDEGPFDYQAEGEDGPVTVPCHRYVKPVMAGGTGGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NEY7</accession>
    <name>A0A0F7NEY7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_31035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019141.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_31035"/>
    <dbReference type="EnsemblBacteria" id="AKH85913">
        <property type="protein sequence ID" value="AKH85913"/>
        <property type="gene ID" value="AA958_31035"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_31035"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6559"/>
    <dbReference type="OrthoDB" id="1513550at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008734">
        <property type="term" value="F:L-aspartate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005288">
        <property type="entry name" value="NadB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42716">
        <property type="entry name" value="PTHR42716"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="532" mass="57805" checksum="2237016D6DB1B282" modified="2015-07-22" version="1">MHADVLVVGGGTGGVAAALGALRAGRSVILTEEYEWLGGQLTSQAVPPDEHTWIEQFGATASYRALRDGIRDYYRRHYPLTAAARAKPDLNPGAGHVSRLCHEPRVAVAVIDELLAPYRGAGRLTVLQPYRPVAAETDGDRVVSVTVERPGGGEPLVLTAPYVLDATETGELLPLTGTEYVTGFESGAETGEPSGPDEAQPLNMQAVSYCFAVDHVDGDHTIDRPASYGFWRDYEPEFWGAPLLSWRAPHPRTLELVEREFTPNPGDDPLAVVADQRRSGGDTNLWTFRRIAARDQFAPGTYASDVTLVNWPMVDYFEAPVIDVPDAAARLEEARGLSLSLLYWMQTEAPRPDGGTGFPGLRLRGDVTGGGADGLAMAPYIRESRRIRAEYTVVEQDLSLDVRGGKGAVSYPDSVGIGMYRIDLHPSTGRDTYIDVPSSPFEIPLGALLPQRTENLVPAGKNIGTTHITNGCYRLHPVEWNIGEAAGLLAAHCLTHGLTPRAVRNTPRLLQDFQRTLTAHGVELRWPDISGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NF10</accession>
    <name>A0A0F7NF10_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH luxR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_17630</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_17630"/>
    <dbReference type="EnsemblBacteria" id="AKH86851">
        <property type="protein sequence ID" value="AKH86851"/>
        <property type="gene ID" value="AA958_17630"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_17630"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3711"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="239"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH86851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="305" mass="34144" checksum="AE91ABC87DBCB8A1" modified="2015-07-22" version="1">MRAGRVSRSEGEEVPCLIDLMLLLPDPDDSRWLRPVPPSTALARLEHPIEREIQERRDQTLALADAFEPFLSITQGRTTVSSAITELSGVTNIDAIVGRATAECEKELLTVQPGGTRPPELLDKAVDRVRPLVDRGVRIRSLYQHTARHNYGLLAYQERVANDLMELRTLEELVDRLIIIDRKVAFVPAHRDRPVKLNRDSAVEVRHPGLVEYFVGVFHHLWQLATPLDEDVHYEHPEPDGITGVQRSIAKLLVEGHVDEVIADRLGMNVRTCRAHIAKLATTLGSNGRAQLGYLIARSGILDQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFA9</accession>
    <name>A0A0F7NFA9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">[Fe-S]-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_32470</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019381.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_32470"/>
    <dbReference type="EnsemblBacteria" id="AKH86154">
        <property type="protein sequence ID" value="AKH86154"/>
        <property type="gene ID" value="AA958_32470"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_32470"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6853"/>
    <dbReference type="OrthoDB" id="1087129at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005805">
        <property type="entry name" value="Rieske_Fe-S_prot_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00162">
        <property type="entry name" value="RIESKE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="5">
        <location>
            <begin position="417"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="488"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH86154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="509" mass="54666" checksum="BAD12667C3EF8C67" modified="2015-07-22" version="1">MTSHWIETAPGEPRPPLREGVAVDLAVVGAGVVGLSTAWEAAAAGLSVVVVEASRIAAGVTGHTTAKLSALHSEAYRNVRRAHGRTAARHFAESQADAVRRVADLSAELGIDCELERAPAFTYAQSNESLPEVREEAEAAAEAGLAVELVDGDGTTGPPFPVRAAVRLDDQIQFHPRKYLLGLADDLAARGGLVFEGSRVTSVSAADPCVLTTADGTRLQARDVVVATHYPILDRALLFARLRPRRELVVTRVIPEADDPGGMYLTQEQRTRSARTAPYGPGRRLLIVTGEKFTPGARDVRARLERLNRWTDEYFPGTEPAAGWAAQDNWTGDHVPFVGRLHPGARHLYVATGFAGWGISGGVMAGRLLTGLLTGDEPPWAGLYDPRRLHPLREGPHLLGNQAHVARRFAGDRLSGATAASADDVPRGGGAVVRHGTGHVAVHRDADGKLHRVRARCTHLGCLVRFNDAETTWECPCHGSRFDVDGHVLQGPATRPLRPTGREESREEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFB0</accession>
    <name>A0A0F7NFB0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_27650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018616.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH85382">
        <property type="protein sequence ID" value="AKH85382"/>
        <property type="gene ID" value="AA958_27650"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_27650"/>
    <dbReference type="OrthoDB" id="2030026at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH85382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="73" mass="8359" checksum="9D0D4E2CDAEE3219" modified="2015-07-22" version="1">MTLLRVELDADRDRARRFDARVRRGEPFPKERQLVIDEAWAHGYTPTGKVTYRGIGQGQPATLKFDVEVDVST</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFC6</accession>
    <name>A0A0F7NFC6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Aminodeoxychorismate synthase</fullName>
            <ecNumber evidence="2">2.6.1.85</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_32560</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the anthranilate synthase component I family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.85" evidence="2"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019396.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_32560"/>
    <dbReference type="EnsemblBacteria" id="AKH86169">
        <property type="protein sequence ID" value="AKH86169"/>
        <property type="gene ID" value="AA958_32560"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_32560"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6873"/>
    <dbReference type="OrthoDB" id="1786019at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046820">
        <property type="term" value="F:4-amino-4-deoxychorismate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009396">
        <property type="term" value="P:folic acid-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01743">
        <property type="entry name" value="GATase1_Anthranilate_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005802">
        <property type="entry name" value="ADC_synth_comp_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019999">
        <property type="entry name" value="Anth_synth_I-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006805">
        <property type="entry name" value="Anth_synth_I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006221">
        <property type="entry name" value="TrpG/PapA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236">
        <property type="entry name" value="PTHR11236"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04715">
        <property type="entry name" value="Anth_synt_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="SSF56322"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00553">
        <property type="entry name" value="pabB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00566">
        <property type="entry name" value="trpG_papA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GATase" evidence="5">
        <location>
            <begin position="5"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Anth_synt_I_N" evidence="7">
        <location>
            <begin position="253"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="Chorismate_bind" evidence="6">
        <location>
            <begin position="430"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="506"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH86169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="709" mass="77500" checksum="E694B5DFD5C9EC30" modified="2015-07-22" version="1">MRTLLVDNYDSFTYNLFHYLAEVNGREPVVLRNDDAGWDPGMLAEFDSVLISPGPGRPERPEDFGICQEIIDNGSLPILGVCLGHQGIAHAFGARVTRAPEPRHGRVSPVFHEGNRLFAGLPEPFDVVRYHSLAVTDLPWELRPTAWTDDGVLMGIEHRDRPLWGVQFHPESISTAHGHRLLRNFRELAEEFGGAGRGTAVVAAPTPAAGGTSRASSRSVAPRSRSPRRLRVLTTALPTRWSDEVAFDRLFGAHEHAFWLDSSAAASEHGRFSIMGDASGPLARVARADTWDGSVTVERSTGVETVRGELFTWLEEDLRSLSVELPELPCDFALGWVGYLGYELKAECGGAASYRSDEPDAAMIFADRALVFDHATSTTHLLALTEDGDEGPGRAWLADTAERLGEIAGQEPHYVPPPAKDATLRLRHDRDRYLELIAHCQEQIAAGETYEICLTNLLQADVAVPPWQSYQFLRRLTPAPFASLLRFGEISVLSTSPERFLRISADGTAESKPIKGTRPRGDSESEDILLRKDLAASEKDRSENLMIVDLVRNDLGRTAEVGSVRVPRIYDVETHPTTHQLVSTVTSQLRPSVSAVECVRAAFPGGSMTGAPKIRTMKIIDSLEAGPRGVYSGAIGYFSLSGACDLSIVIRTLVVTPSRVKYGVGGAIVALSEPDEEFEEIAVKATPLLRLLGAEFPGRLPVDLIRTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFK7</accession>
    <name>A0A0F7NFK7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoribosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_32255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019351.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_32255"/>
    <dbReference type="EnsemblBacteria" id="AKH86123">
        <property type="protein sequence ID" value="AKH86123"/>
        <property type="gene ID" value="AA958_32255"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_32255"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6810"/>
    <dbReference type="OrthoDB" id="1567476at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="1">
        <location>
            <begin position="12"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="214" mass="22262" checksum="C63FA958DCB07D24" modified="2015-07-22" version="1">MRFHDRSEAGRALARRLRDGRPGAGAPRDAVVLALPRGGVPVGYEVARALGAPLDVLLVRKIGHPHHPEYGLGAVAGDAPPLYDPDALAGAGLTERDLAATARREVTELRRRESLYRGGRPAPALAGRWAVVVDDGLATGATARAALRAARAAGPARLTLAVPVASPGGLSAVRGEADDVTCLYAPPDFGAVGLWYDEFEQLTDADVLELLGTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFN4</accession>
    <name>A0A0F7NFN4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Inner-membrane translocator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AA958_29210</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_29210"/>
    <dbReference type="EnsemblBacteria" id="AKH87106">
        <property type="protein sequence ID" value="AKH87106"/>
        <property type="gene ID" value="AA958_29210"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_29210"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6158"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015658">
        <property type="term" value="F:branched-chain amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06581">
        <property type="entry name" value="TM_PBP1_LivM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043428">
        <property type="entry name" value="LivM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30482">
        <property type="entry name" value="PTHR30482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519493" evidence="8">
        <location>
            <begin position="25"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="59"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="206"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="241"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="287"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="321"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH87106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="345" mass="35236" checksum="7897954A0617491E" modified="2015-07-22" version="1">MRRPRALAVLAVCVTALLLPQVLAGSDVPVYVTLLLSAIVVTGLSMLMGYAGQVSLGHAAFYLIGAYTAALIATHDQPTWLGLAAAPFASAVVAAVIGVPLLRLRGHQLAFATLAIQLILLNVVGQQEWTGGDIGLQGVPRLTLAGYEFATAASYAYLALAALAVAVVITRNVVASRPGRGLRALATSEVAAESAGVPVVTYKLAVFSLSAGFAGLAGGIYAFYTGYVAPGSFPVLLSFEFVVMAVIGGLGTIWGALAGATAITLLLQELNELGTAEGMPSSAPSVLSYAVYGLLLVLVVLFLPRGLVPSATAWWERRRARRHTDGDAEGEGGGGDGGDGGDGGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NGI4</accession>
    <name>A0A0F7NGI4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_04795</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_04795"/>
    <dbReference type="EnsemblBacteria" id="AKH86549">
        <property type="protein sequence ID" value="AKH86549"/>
        <property type="gene ID" value="AA958_04795"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_04795"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1010"/>
    <dbReference type="OrthoDB" id="1574819at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH86549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="182" mass="19600" checksum="5658FFE5850C61BD" modified="2015-07-22" version="1">MFPDTPAVLLLTGVQAAGKSTVAQLIAERLPRSAHVRGDVFRRMVVGGRAEMTPEGSPEALRQLQLRYGLMARTADAYAAAGFTAVAQDVVLGAELPRTAALFRTDPLLVVVLAPRPAAVAAREAGRAKTAYGPAWGVRELDCVLRDETPRLGLWLDTSDQTPAETADEILARAWQEARVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NGR1</accession>
    <name>A0A0F7NGR1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_08790</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019882.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_08790"/>
    <dbReference type="EnsemblBacteria" id="AKH86624">
        <property type="protein sequence ID" value="AKH86624"/>
        <property type="gene ID" value="AA958_08790"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_08790"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1852"/>
    <dbReference type="OrthoDB" id="7548at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002543">
        <property type="entry name" value="FtsK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13401">
        <property type="entry name" value="AAA_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01580">
        <property type="entry name" value="FtsK_SpoIIIE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50901">
        <property type="entry name" value="FTSK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FtsK" evidence="3">
        <location>
            <begin position="414"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="domain" description="FtsK" evidence="3">
        <location>
            <begin position="749"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1343"/>
            <end position="1371"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="432"/>
            <end position="439"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="767"/>
            <end position="774"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH86624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="1371" mass="147615" checksum="7049F046058627C5" modified="2015-07-22" version="1">MVTVVLPGGAERDVVLGAPDSARVSVVAQALGVWCGGRPGPERLFLADATELPPGVALADVPVRPGSRLWLGEPPADPRWSLGTPEAMHGELLRKGIAEPRDGGTLLVSHRRRGAAEPGRGGWRRLLTRERRRPGYEPWLVNPRLLLSSPAELWHRAADSVEFLRLALGYTINPREEGLPPITVDLPRTGVLGLAGRHAAGEVGAWLVAQIVATHSPADVDVRVLSTGRDDAAWDFLRFLPGTSSSGPRITHDAGAAARHLGDLLGRRSAHRGGTQPAAAVLVLDGARRLGALPGVKELLRSGPRYGVFSICLENEVQLLPAECRTVAETDGSARLWREGELVNADWYAHRARPAGTDRVGRILAPLRDPASEQPDSPRLLGLLDLPLFDMDAQRQRWARPSHGLSAPIGESQGVPVAIDLVRDGPHALVAGTTGSGKTEFLRTWIASMAACHPPDAVSFVLVDYKGGSAFADCARLPHTVDVIVDFDAYLVERTLTGLAAELRRREELLLRTGVHDIGQYTDLFRAGDMRAAEPLPRMVLVVDEFASLTREFPDFVSGLVEIARRGRSLGVHLVLATQRPGGVVTPDIRANTNLRIALRLVDRNESTDVIDEPDAAWLGKSEPGAAYVRTGAETLVRLRTARVGVRHAPVPEHWSDVRVRDAHGDPEDSGSLRVESEPTGMTDLTSLVHQLAAAAAVLGIPRPPAFLPPPLADVIQLDAPLAETDLPERGRDLVPVPIGLADVPEDQFRTVAVLDLADKLPLLAAGGPRSGRSQLLRTVAGSVARQHSSADVHLYGIDCGTGALQALTELPHCGAVVSRNERDRLTRLLDRLTTTVRVRQSQLAAEAFADAAAQRQAVAAHRRLPYLLVFVDGWEGFVDAMQDVDYGRPVEDFLRLCREGPRVGVCPVVVGGPQVLHGRIRAAAADVLVLRQADETDYVDAGIRPRLVPGRMPPGRALYAEGRDRTVVQIALLPGGAETGRGQAEALARIGAAARQRDAGVPPTRRPFRVDALDLAADRFHVGGGTGRPVGRDAELYWLRDRYATGTSVALLGPRRAGKTWVLGELERRLVADGAGQVRKLTVPHRASPVDSPDQLAALLDPAVRGATSPAEALLNRAADRAARADREAFLLDEVGRLAEYHPAAVSWLRDLGQAGAWLVYTGTEKDWQTVVRSALTAPGSSFGNDVDKRILGPLGEPHALAFLTGTAANLGVDIAPDRAGARILALVGTWPFYLQVMGDSVVRAVQADDRRPLTSGPALEELCRQELLIGRSEQFQSRWAEIGPAGRAALLHTPGAPPPEPAPAQRMELRDVGLLRPGDVWLADRPFFDWIALSQVSLRDESLRGRGRRVPPGEEPRAEGPRTDEEQAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NH22</accession>
    <name>A0A0F7NH22_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F5/8 type C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_31750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_31750"/>
    <dbReference type="EnsemblBacteria" id="AKH86032">
        <property type="protein sequence ID" value="AKH86032"/>
        <property type="gene ID" value="AA958_31750"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_31750"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6704"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F5/8 type C" evidence="1">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="95" mass="10461" checksum="2E27FEAE788ADAA7" modified="2015-07-22" version="1">MSVDTGARQRLAGVRYLPRQDGGINGRVEDYEVLVSADGERWQTVAAGSFPEDRTEFTVPFREVKARHIALKVLSEHGASDTFASVAELDAVRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NHB0</accession>
    <name>A0A0F7NHB0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Squalene synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_32195</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AKH86112">
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        <property type="gene ID" value="AA958_32195"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_32195"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6798"/>
    <dbReference type="OrthoDB" id="1449625at2"/>
    <dbReference type="Proteomes" id="UP000034283">
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017827">
        <property type="entry name" value="HSQ_synthase_HpnC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Squ/phyt_synthse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044843">
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    </dbReference>
    <dbReference type="InterPro" id="IPR033904">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00494">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01212">
        <property type="entry name" value="Phytoene_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01018">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03464">
        <property type="entry name" value="HpnC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH86112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="298" mass="32259" checksum="E26D8F96A3DA7E9C" modified="2015-07-22" version="1">MTPADDAPSRAVLGQAADENFPVAPFFLPRAWRGDLMALYGYARLVDDIGDGDLAPGGADAAALGLGPDEADDTLALLDALEADLERVFTPGATPGHPLMRRLRPTVRRHRLSPQPFHGLLQANRQDQKVRRYETYAELEGYCELSANPVGRLVLAVTGTESPERIRRSDAICTALQIVEHIQDVAEDLGRDRIYLPAEDMRRFGVTEADLARTSAGEPVRALIRYEADRAARLLDEGAPLVASVRGRLRLLLAGFVAGGRAALAAVAAAGHDVLPGPPKPTRRRLLREVGSTLRREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NHP2</accession>
    <name>A0A0F7NHP2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phenylacetic acid degradation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_16400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_16400"/>
    <dbReference type="EnsemblBacteria" id="AKH86823">
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        <property type="gene ID" value="AA958_16400"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_16400"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3452"/>
    <dbReference type="OrthoDB" id="1389523at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010124">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007814">
        <property type="entry name" value="PaaA_PaaC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011882">
        <property type="entry name" value="PaaC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05138">
        <property type="entry name" value="PaaA_PaaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037834">
        <property type="entry name" value="PA_CoA_Oase3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02158">
        <property type="entry name" value="PA_CoA_Oxy3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH86823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="234" mass="25368" checksum="5043A24C0C88E265" modified="2015-07-22" version="1">MGALALGDDALVLSHRLAEWTGHAPVLEEEVALANIALDLLGQARTLLSLVGDEDELAFLREERAFRNVQLVEQPNGDFAHTVARQLYFSVYQELLYGQLAAAGEPSPLAPLAAKAVKEVAYHRDHAEQWTLRLGDGTETSHARMRAGLDALWRFTGELFRPVGGLAVDWAGLEAAWLATVGGVLERATLALPEGPRGTGWSAGAGREGVHTEPFGRMLAEMQHLHRSHPGASW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NHR0</accession>
    <name>A0A0F7NHR0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Multidrug ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AA958_23020</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_23020"/>
    <dbReference type="EnsemblBacteria" id="AKH86979">
        <property type="protein sequence ID" value="AKH86979"/>
        <property type="gene ID" value="AA958_23020"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_23020"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4851"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034194721" evidence="8">
        <location>
            <begin position="26"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="252"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="31"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="347"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="381"/>
            <end position="388"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AKH86979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="613" mass="65750" checksum="AD148335CEA68D4D" modified="2015-07-22" version="1">MRLTPRLAAGHLAAALSLALAAAPAATVVHVVLTLLVGVLPVAVTWLTKVVLDSLADGGAGSLLWPALGLATAAGVLSVSPRVIAYLQAESSRRMRLVAQERIFARLGERLRGLSTLENPWFHDRVRIAVGTGGIAPGKLVAGAAGIGRSATMLTGFFATVLYLSPWLAASLAAAAIPTLAVELSVSRRRARVLWRLSSAERRRIFYESLLTDPHSGKEVRLLGLGRLFRTRMGDELRAANAAERTLDRRELLLQTSLMLLGAVTAGAGLVWAIGRARNGEMSVGDVTVFVAAVAGVQAGLSELIGQLGNVHQSMLEFDHYQVASAVPADLAVPAPAAAVPPLRRGIVLRDVWFRYTDDQPWILRGVDLTIPAGQSLALVGPNGSGKSTIVKLLCRLYDPTRGRITWDGVDLRDTDPDEVRNRISAVFQDYLQLELPAAENIGLGDVPHRDDRARIAGAARAAQVHDDLSRLPHGYDTMLTRMFVDNADRDDPETGVLLSGGQGQRVAIARALFREGRDLLILDEPSSGLDAEAEHTIHTRLREHREGRTSVLISHRLNTTRDADQIAVLREGRISELGDHDALMRAAGSYAELFSLQAAGYAGPVAAAEGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-12-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NJ90</accession>
    <name>A0A0F7NJ90_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_17310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86842">
        <property type="protein sequence ID" value="AKH86842"/>
        <property type="gene ID" value="AA958_17310"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_17310"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3640"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH86842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="122" mass="13531" checksum="9C72358BCE0122AA" modified="2015-07-22" version="1">MRQSFTAVIERNATLTGEFTTEPYEAAWAREARWFVRVLDASGRAPRMLVRTQISPDGLHWCDLDRGAEQSVDPDEGPLHSWPAEGFGGWLRLRGTVVDEPAEATGDTASSLKVLIYLALKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NJQ1</accession>
    <name>A0A0F7NJQ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Polyprenyl synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_24315</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_24315"/>
    <dbReference type="EnsemblBacteria" id="AKH87012">
        <property type="protein sequence ID" value="AKH87012"/>
        <property type="gene ID" value="AA958_24315"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_24315"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5124"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH87012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="366" mass="38581" checksum="F862182ABC3ECDB0" modified="2015-07-22" version="1">MFRPPSGLELPKKNGAAAGKDLPSDDATEELVGRAVARIEDLLSAEIARWRAVDPRAALPVEGIAELIAAGGKRLRPRFCVSGYLAAGGAPDGSAAEDAVIGAAAALELLHASALLHDDILDNAPTRRGAPTLHAKHAAIHADKGWTGEPRRYGEGIGILAGALAYGYATRLAAGLTGTAMEIWTDLGTEMLVGQQLDIALAAEPKPDTDLARWIAVCKSGRYTIHRPLALGASLAGRQDLQEVFEAYGVAAGEAFQLRDDLLDAFGDSETTGKPAGLDVSEHKMNLLLALAATKDARVAELVAGSTWDTEALSAAMLASGVRQEVEEHIDQLVGTARTALEGAPLADGWRERLDLMVDYVAYRDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A097H0W8</accession>
    <name>A0A097H0W8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Phenazine biosynthesis protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">Putative FMN-dependent oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">cnq726</name>
        <name evidence="10" type="ORF">AA958_30785</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="ChemBioChem" volume="15" first="2385" last="2392">
            <title>A Membrane-Bound Prenyltransferase Catalyzes the O-Prenylation of 1,6-Dihydroxyphenazine in the Marine Bacterium Streptomyces sp. CNQ-509.</title>
            <authorList>
                <person name="Zeyhle P."/>
                <person name="Bauer J.S."/>
                <person name="Steimle M."/>
                <person name="Leipoldt F."/>
                <person name="Rosch M."/>
                <person name="Kalinowski J."/>
                <person name="Gross H."/>
                <person name="Heide L."/>
            </authorList>
            <dbReference type="PubMed" id="25224759"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CNQ-509</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNQ-509</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="5">Binds 1 FMN per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the pyridoxamine 5'-phosphate oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="KJ451627">
        <property type="protein sequence ID" value="AIT42116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019101.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_30785"/>
    <dbReference type="EnsemblBacteria" id="AKH85873">
        <property type="protein sequence ID" value="AKH85873"/>
        <property type="gene ID" value="AA958_30785"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_30785"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6507"/>
    <dbReference type="OrthoDB" id="1542844at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004733">
        <property type="term" value="F:pyridoxamine-phosphate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008615">
        <property type="term" value="P:pyridoxine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000659">
        <property type="entry name" value="Pyridox_Oxase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019576">
        <property type="entry name" value="Pyridoxamine_oxidase_dimer_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10851">
        <property type="entry name" value="PTHR10851"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10590">
        <property type="entry name" value="PNP_phzG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000190">
        <property type="entry name" value="Pyd_amn-ph_oxd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00558">
        <property type="entry name" value="pdxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 5" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="7">
        <location>
            <begin position="38"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="PNP_phzG_C" evidence="8">
        <location>
            <begin position="174"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="142"/>
            <end position="143"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000190-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIT42116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AKH85873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="212" mass="23871" checksum="FF230EB427CC08D7" modified="2015-01-07" version="1">MHTSKFESLTVENDADFPEYDDPPADPVGLVQRWLDRAVELQVREPKALALATADKRGRPSSRIVLVSAIDDRGVLFTSHATSRKGREIEENNWAAGLLYWRETGQQIKLSGPVEPVSLAESDSLWQARAVPLHAMSAASRQSEPLADPAALRAEAARLGADGKALDRPERFYGYRLQPHDIEFWAHRPDRLHLRLRYDRDGDGWTSVRLQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MXE6</accession>
    <name>A0A0F7MXE6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF3152 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_00555</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH80905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014271.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_00555"/>
    <dbReference type="EnsemblBacteria" id="AKH80905">
        <property type="protein sequence ID" value="AKH80905"/>
        <property type="gene ID" value="AA958_00555"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_00555"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.130"/>
    <dbReference type="OrthoDB" id="1478995at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022603">
        <property type="entry name" value="DUF3152"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11350">
        <property type="entry name" value="DUF3152"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3152" evidence="2">
        <location>
            <begin position="116"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH80905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="298" mass="31824" checksum="9F3167BA53920BD0" modified="2015-07-22" version="1">MAGRTRRSTRIAAGAVALALLGAAGVVVWLFALPPSLVPDALRSHAPQAVADDAKPPPLRVQQRASAFRVPYRAPASGLPHSSGFAVGGSADMPALGDLLYRRRMSETFPVPAGLDGPGTFETVPGHDPAPGTGRVVRYRVDVEDDVPLDGRMFARAVEETLNDARSWGDDGRLAFERVSTGTADFAVTLASPGTTGEWCAMSGFDTTVDNVSCDSGMTERVLINAFRWAQGSTTYGDDMFGYRQMLINHEVGHRLGHLHASCARDGARAPVMMQQTLSLTADGARCETNPWPYPDRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MXM7</accession>
    <name>A0A0F7MXM7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Exonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_01130</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AKH81000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AKH81000">
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        <property type="gene ID" value="AA958_01130"/>
    </dbReference>
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    <dbReference type="PATRIC" id="fig|444103.5.peg.249"/>
    <dbReference type="OrthoDB" id="1143316at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        </location>
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            <begin position="92"/>
            <end position="112"/>
        </location>
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        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="451"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="620"/>
            <end position="652"/>
        </location>
    </feature>
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        <location>
            <begin position="257"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="551"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH81000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="1004" mass="107009" checksum="29A60D6DF1E0B8E6" modified="2015-07-22" version="1">MRLHRLAVAAFGPFAGTQEVDFDALSGAGIFLLQGATGAGKTSVLDAVCYALYGGVPGVRQGGTLRSHHAEPHTPTEVALDFTLAGRRLEVTRRPAQPRPKRNGTGVTTERATSLLREHDPAAGEWRGLSRSHQEIGEEIGRLLGMTREQFCQVVLLPQGDFARFLRADAEARAKLLGRLFDTGRFAAVEDHLAELRRRSQEAVRDGDERLLHLAHRIRQAGGPATAGDPEGWSPDDAKPGEADLADGVLGYAAVARATARELADAAELRLRTAESAHAAAASHLQDVRELARLQRLHADARQRQQALAERRQERAALGEKLRRARDAAAVAPALELRDRTAAAARQAAAAEEAARAALPGTVAGGGPDQLDAHEARTRQELGALDAARAAAARSAAIARELAALDEESRADEDVLREAAGWLDDWDTLRGGLQRRVDEAQGAATRAEQLAAEHEGARRRLDAAERRDELAGRTDEARRAHLDAGERAGRAHETWLELKERRLDGMAAELAARLADGEPCPVCGSAAHPAPATVDGAHVGEREENEALAAYRAAERVREEAALRLDSLRQARDAAAEAAGEESREALAAAVARVAGELSRARELAAGALAVREQLDQAHEEHARRVRGRQQAESRAASRASRADALTAERAARDAEVRAARGGAAGVEERAEQLTSLAGRLAVAARAAREAAAAAERSKDADARVADAAYRARFATPEEAAAALLDPAALREVEARLEAWQAEEAAVAEALAEPRAAAAAARPPAAVGAAEEAFAAAAARLRSAATAGDNARERCDALAGLSAEAADRVRRLAPLRREHHRVARLAALAAGTSAENERKMRLESYVLAARLEQVAAAATARLARMSSGRFTLVHSDERAHGRGRHGLGLHVVDAWTGTERDTATLSGGESFFASLALALGLSDVVAEEAGGVRLDTLFIDEGFGSLDEQTLDEVLDVLDALRERDRTVGIVSHVPELRRRIPTQLEVVKGRSGSYVRHRTAADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MZ11</accession>
    <name>A0A0F7MZ11_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_00900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH80961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH80961">
        <property type="protein sequence ID" value="AKH80961"/>
        <property type="gene ID" value="AA958_00900"/>
    </dbReference>
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    <dbReference type="PATRIC" id="fig|444103.5.peg.200"/>
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    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046291">
        <property type="entry name" value="DUF6328"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
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            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="125"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH80961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="192" mass="20556" checksum="25E24529CDFB309A" modified="2015-07-22" version="1">MDRDRNDDEHGTAAPAARAPDTAADADAAYARHETALERDDRNFVELLQELRVTQTGVQILFAFLLTLAFTQRFTELDSLQRGTYVTTLLLSVAAAVLLTAPAAVHRGLFRRNVKRRIVDVSSRLAAAGLGVLAFALSGAVLLVVDVVLGRPAGVAAGASVLVFIAGLWAALPWGLSRSIAARRARRDGRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MZ21</accession>
    <name>A0A0F7MZ21_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptide ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_00950</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH80971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014337.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_00950"/>
    <dbReference type="EnsemblBacteria" id="AKH80971">
        <property type="protein sequence ID" value="AKH80971"/>
        <property type="gene ID" value="AA958_00950"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_00950"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.210"/>
    <dbReference type="OrthoDB" id="1181903at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
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        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="20"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="56"/>
            <end position="63"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH80971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="260" mass="28202" checksum="ED7032A66AC62436" modified="2015-07-22" version="1">MSTPAALDRREAERPAGVAARAGGLTKTYGSGETAVVALDAVDVEIHRARFTAVMGPSGSGKSTLMHCLAGLDTVTSGRIWLGDEEITGLGERELTRLRRDRIGFMFQSFNLLPTLNALENITLPMDIAGRKPDPGWLDRVIDTLGLRDRLDHRPSQLSGGQQQRVACARALASRPELIFADEPTGNLDSRSGFEVLGFLREAVDQLAQTVVMVTHDPGAAAHSDLVLFLADGRIVDQMPQPTSEAVLERMKRFDGTRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MZD5</accession>
    <name>A0A0F7MZD5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosyl hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_01605</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014440.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_01605"/>
    <dbReference type="EnsemblBacteria" id="AKH81076">
        <property type="protein sequence ID" value="AKH81076"/>
        <property type="gene ID" value="AA958_01605"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_01605"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.352"/>
    <dbReference type="OrthoDB" id="469334at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030458">
        <property type="entry name" value="Glyco_hydro_31_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025887">
        <property type="entry name" value="Glyco_hydro_31_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13802">
        <property type="entry name" value="Gal_mutarotas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00129">
        <property type="entry name" value="GLYCOSYL_HYDROL_F31_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gal_mutarotas_2" evidence="3">
        <location>
            <begin position="169"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH81076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="777" mass="84261" checksum="A045827ADCC71C8A" modified="2015-07-22" version="1">MDPSALTRRARALRAAVRNRRADATALPRRRAERARVPGLATGAEAVPGGGVIRFARSALELRVTTTGAVFCGWDGAEPEPSYALARAPETDARVELEPDAAGGGWRVVSERVTVAVSRRGAVEVRTPAGVVLRREQPPRWWESPAGAPEEDVREEVRRWVQRAHVAPDARFFGLGGRAAGPSLPDGRYRLWNSDPGGAFAPGDDPLSLTMPVQFVVSDAGCHLLFHDNSWDGSVELHRGAEGGGSGHDRPGRVEMRMAGGPLRYWVMAGTPARVLQSWTALTGAPAVPPAWALGYQHARRDFGGAEGVRRVVRGYRERGLPLAAVHLDIDHYDGHRVFTSDPHRFPDLPRLARELAADGVRIVSVVDPGVKAEPGYPVYDAGVAADAFVRDARGRPVRGVVWPGDAVFPDFTDPRARKWWGGLYAERLQQGFTGFWHDMNEPASFTAFGEKTLPRSARHALEGRGGDHREAHNVYALQMARAAYGALTGLQPDRRPFLFSRSGWAGLQRYGGTWSGDVATGWPGLSASLALVIGLGLCGVPYSGPDIGGFSGRPDPELYLRWLQLGSYLPLFRTHCALGAGRREPWEFGPEVLEHAGAALRERKRLRPYLATLARLAERSGAPFVRPLWWYDPADRALRETEDAFLLGDALLVAPVLAAEARRRAVRLPLGLWYDTATGRALTGPGTVELEAPLARVPVLARAGAVLPVAGADGGTELEVWAPPPGATGGGVVVRDDGDGWEAPRLERYVTRWAGRTTVLREDGTEPDLPVRVRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MZV3</accession>
    <name>A0A0F7MZV3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">L-lysine N6-monooxygenase MbtG</fullName>
            <ecNumber evidence="5">1.14.13.59</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Lysine 6-N-hydroxylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Lysine N6-hydroxylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Lysine-N-oxygenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Mycobactin synthase protein G</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AA958_06030</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-lysine + NADPH + O2 = H2O + N(6)-hydroxy-L-lysine + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:23228"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57820"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.14.13.59"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Siderophore biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the lysine N(6)-hydroxylase/L-ornithine N(5)-oxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.59" evidence="5"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015188.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_06030"/>
    <dbReference type="EnsemblBacteria" id="AKH81835">
        <property type="protein sequence ID" value="AKH81835"/>
        <property type="gene ID" value="AA958_06030"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_06030"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1260"/>
    <dbReference type="OrthoDB" id="324612at2"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047091">
        <property type="term" value="F:L-lysine 6-monooxygenase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901566">
        <property type="term" value="P:organonitrogen compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025700">
        <property type="entry name" value="Lys/Orn_oxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42802">
        <property type="entry name" value="PTHR42802"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13434">
        <property type="entry name" value="K_oxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="451"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AKH81835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="474" mass="51858" checksum="C522FB66CE148CEA" modified="2015-07-22" version="1">MPAEQTGRRRPLDLAGIGIGPFNLSLAALAARVRGLTTAFYERRPEFRWHPGLLIEGTTLQVPFLADLVTLADPTSPFSFLNYLRLRERLYPFYFAERFHAHRAEYDAYCRWVSGQLPGLHFGHQVEDVRWNAESGLFEADFAQLDAAGGAAALGRAHARHLVVGVGTEPYVPEALRPLVGSPTADVVHSADYLPHRARLAAAGHVTVVGAGQSGAEVFLDLLRARPAGAEGLHWLARSPAFAPMEYSKLGLEQFTPDYAHYFHGLPEEVRDDLLPRQWQLYKGIDGETIAAVHDELYRRTLGGGWPDVVLTPGVTVRTAGRLGSDGIELHLEHAAQGARETLRTDAVVLATGYRERPLDGLLAPLEPLLQRDAAGRPKVDERHRLVLDPEVTGRIYVQNAERHTHGVGAPDLGLAAHRSAVILDDVTGAEPYPLPSRTAFTTFGLRQDRRARPGEAAPRIPGPCAPDPGTVRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MZY5</accession>
    <name>A0A0F7MZY5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_02730</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014629.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_02730"/>
    <dbReference type="EnsemblBacteria" id="AKH81266">
        <property type="protein sequence ID" value="AKH81266"/>
        <property type="gene ID" value="AA958_02730"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_02730"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.583"/>
    <dbReference type="OrthoDB" id="1437290at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011075">
        <property type="entry name" value="TetR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16859">
        <property type="entry name" value="TetR_C_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="17"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH81266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="199" mass="22000" checksum="7F45B138FCB1072B" modified="2015-07-22" version="1">MVVQDTSTTGRRSRLSAEREQELFDAVLDQLREVGYEALTMDAVAARTRSSKATLYRQWHSKPHLVATALRHSKPVRSAGIDTGTLRGDLVQFADGVCQNAEKDSALLRAVAFAQQSNEELQQAMRHLLIEPELAAFQELIDRAVARGELPADIPAAKFVPHMMLGAMLARPLIENAPVTSDYLVRYVDAVILPALHMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0I8</accession>
    <name>A0A0F7N0I8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zinc metalloprotease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AA958_04030</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CNQ-509</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8 10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8 10">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the peptidase M50B family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014851.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH81496">
        <property type="protein sequence ID" value="AKH81496"/>
        <property type="gene ID" value="AA958_04030"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_04030"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.845"/>
    <dbReference type="OrthoDB" id="1401629at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008915">
        <property type="entry name" value="Peptidase_M50"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016483">
        <property type="entry name" value="UCP006404_Pept_M50_CBS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02163">
        <property type="entry name" value="Peptidase_M50"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006404">
        <property type="entry name" value="UCP006404_Pept_M50_CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0129">CBS domain</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="8" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8 10" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
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        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="230"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M50" evidence="11">
        <location>
            <begin position="64"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M50" evidence="11">
        <location>
            <begin position="149"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR006404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AKH81496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="389" mass="41770" checksum="9837A4E34256BCC3" modified="2015-07-22" version="1">MSEERRGDRPGRGGGILMGRPFGVPVYVAPSWFLVAALITWVFGGQLERILPELGALRYVIALFFAVAFYASVLVHELAHTRVALHYKLPVRRIQLQFFGGVSEIEKESETPGREFWLAFAGPLLSLVLAGGFYGALQLVEEDTVPAVLLAALTISNLIVAVFNLLPGLPLDGGRMLRAAVWKVSGKPMTGTVVAAWVGRALAVATLIGLPLFTHSRASDPGSVDTVTDALLAAILAAIIWTGAGNSLRMARLRERLPELRARALTRRAAPVTADTPLSEALRRAEAAGARALVVVDGRGFPTGVVRGAAIAQTPAHRRPWVAVSSLSQDLTDEMKVSAELTGEQLLEHLRESPHSEYLVLEETGHIYGVLATADVERAFVAAMARPQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0M8</accession>
    <name>A0A0F7N0M8_9ACTN</name>
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        <recommendedName>
            <fullName evidence="1">Epimerase domain-containing protein</fullName>
        </recommendedName>
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        <name evidence="2" type="ORF">AA958_08035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="8"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
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            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="327" mass="33935" checksum="26A3239338759C6A" modified="2015-07-22" version="1">MSGPPQRILVTGATGFVGGAVTRALLAAGREVTALVRDTSRAEGLAEAGANLHTGDMLRPETYVPLVDGVDAVVHAAQLRVGGRMSKAVLARMHEADRVMSDALAQACLKAGNRLLYAAGTFVYGDHGAEWIDESTPHTPAPLGAGHADGAARLRALTARGLDSVVLYAGFVYGPGGNFKAAFYDQGRAGRLRHPGDGRNHWSCVHLSDLAAGYLAALDRAPAGSGYNLVDDEPLPLAEFTRAIAREMGVSRVSRVPGFAASLALGRPVAASLMTSYRVSNRRARADLGWAPAHPTVAEGLPGTLEALAAGAAAIPPHGSSTKQRGR</sequence>
</entry>
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                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">CNQ-509</strain>
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    </dbReference>
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        <property type="entry name" value="DUF2267"/>
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    </dbReference>
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
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            <dbReference type="EMBL" id="AKH81606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="149" mass="16206" checksum="C2AD46F8E6CD6CFE" modified="2015-07-22" version="1">MISDRHVPPQRPYGTAYEQMLERVRYEGAYPTRERADEAVRLVLAGLGRQLTGEERVDLAGCLPVEAARVLTAQIPDVRPLTGWDFVEDLAAGTGASLATTRWDVGSVFSVVAAYARPDLITRILRQVPAGYALLFGRAELAPAAAANR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0X5</accession>
    <name>A0A0F7N0X5_9ACTN</name>
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        <submittedName>
            <fullName evidence="4">Chitin-binding protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="4" type="ORF">AA958_08515</name>
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    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_08515"/>
    <dbReference type="EnsemblBacteria" id="AKH82270">
        <property type="protein sequence ID" value="AKH82270"/>
        <property type="gene ID" value="AA958_08515"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_08515"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1797"/>
    <dbReference type="OrthoDB" id="1005693at2"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Cellulose/chitin-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03067">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
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    </dbReference>
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    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
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        <location>
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            <end position="338"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="305"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-4" evidence="3">
        <location>
            <begin position="43"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH82270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="338" mass="35394" checksum="0A118BEBED700FDB" modified="2015-07-22" version="1">MTMAVQRLVRAARSLRLRRTLALAGVAGVATAALAVPTPASAHGVAMVPGSRTFLCYKDLIANSSTQMPQNPACKAAVQSAGTTPLYNWFAVLDSNAGGRAQGYVPDGKLCSAGDRSPYNFSPYNAARTDWPLTHLTSGANINLEYSNWAHHPGRFEVYITNNGWSPSKTLAWGDLTHLQTVTNPPQAGGAGSDGGHYYWNLQLPQRSGQHMLFIQWIRSDSQENFFSCSDVVFDGGNGQVTGLTPGAMSADEVKALGAGKENTKADPVKGAHGDHGAAAPQAQAVETLNEGESNLAASSDDSSAVLPAALAGAGAVIFAGGALVYNQRRNGPGRQQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0Z9</accession>
    <name>A0A0F7N0Z9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Branched-chain amino acid ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_01420</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014409.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_01420"/>
    <dbReference type="EnsemblBacteria" id="AKH81044">
        <property type="protein sequence ID" value="AKH81044"/>
        <property type="gene ID" value="AA958_01420"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_01420"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.313"/>
    <dbReference type="OrthoDB" id="1456257at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015658">
        <property type="term" value="F:branched-chain amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06581">
        <property type="entry name" value="TM_PBP1_LivM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043428">
        <property type="entry name" value="LivM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30482">
        <property type="entry name" value="PTHR30482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="117"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="253"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="320"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH81044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="351" mass="37035" checksum="A99A353860EB7AAD" modified="2015-07-22" version="1">MILALLDRLGARRAWLRWGLLAAGLVSVLGLPWVLYPPVAADILCWGLFAVAFDLLLGHAGLLSFGHAAFWGTSAYTTGLIAIHAGVPFPLAVAGGAVAAAVVAVPIGLLAVRRSGIYFAMVTLAFAQMIYFIANQWGDLTGGENGLQGIPRELPGLDLSDSFVYYYAALPLVLAGLAAAWRIVHSPFGRVVAAVRDNPARARALGYSVDRYKVVVFTVSAFLSGLAGGLYAVNHGFASLQEVYWTTSGKVVVMTVLGGIGTLWGSLLGAAAVVRLEDWLSTSGFDEVGIVTGSLFILVVLLFRRGIWGTVSHLLQPRGDTASMQSADSGNGTVRDPAAGDRPERSLVREP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N1A5</accession>
    <name>A0A0F7N1A5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_02315</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_02315"/>
    <dbReference type="EnsemblBacteria" id="AKH81198">
        <property type="protein sequence ID" value="AKH81198"/>
        <property type="gene ID" value="AA958_02315"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_02315"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.496"/>
    <dbReference type="OrthoDB" id="1034540at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
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        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004017">
        <property type="entry name" value="Cys_rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
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        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
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        <property type="entry name" value="FAD-linked_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="SSF55103"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="567"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH81198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="987" mass="104803" checksum="945EA68372DC1883" modified="2015-07-22" version="1">MPLLQPKPSALRPGRGAAAPAPDRVADDLAAGTPEPLRAELTALLGAEKVLTGASDLVRYASDASPYRFVPRAVALAETVADVSALFRFAHEHGRKLVFRAAGTSLNGQAQGEDILVDVRRHWAGVEVLDDAAARARVGPGTTVVRANATLARHGRVLGPDPASAIACTLGGVVANNASGMTAGTTRNSYRTLASLTFVLPSGTVVDTAAPDADERLAAAEPELWSGLLALKAEIEADAELTARIRAKYEIKNTNGYRLDAFLDGATPVQILRGLMVGSEGTLGFIADTVFDTLPLDRHTSTALLFFPTLQAAAAAVPAFNAAGARAVELMDGNTLRASVSVAGVPADWAELPKETAALLVEFRAPDEAAREAYEEAAAGVLAGLDLVAPVGSVAAEGNAFTRDPGRIGGYWKARKAFVTAVGGSRPAGTTLITEDFAVPPGRLAEACEALLELQARHGFDAAVAGHAAHGNLHFLLAFDAAEPADVERYAAFMDDFCRLTVERFDGSLKAEHATGRNIAPFLALEWGERATGLMWRIKELIDPHGILAPRVLLDRDPQAHLRGLKTIPRIEDVADPCIECGFCEPTCPSGDLTTTPRQRIVLRREMLRQPPDAPVTGSLLQAYGYDAVDTCAGDSTCGLDCPVGIDTGQMMKDFRHARHSAREERAAAATARRFRQVERAARLAVAVAHRLGDRVPGAATRLARRAVRPDLVPEWLPEIPAPAARRLPGTVREGAAAVYFPACVNRIFGGPDDARGPNLAEAVVAVSARAGRPVWIPDDVTGTCCATIWHSKGYADGTRVMANRIVEAAWWWTDGARLPVVVDASSCTLGLAHEVVPYLTEASRKLHAQLTVVDSLDWAADELLPHLTVERKTASAVVHPTCSMRHLGNTGRLTALAEAVAEEVVVPDDAACCAFAGDRGLLHKELTASATAREAAEVAAREYDAHLSANRMCEIGMDRATGRSYRSVLLELERATRPAGVRGRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N1I1</accession>
    <name>A0A0F7N1I1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_02525</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial solute-binding protein 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014597.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_02525"/>
    <dbReference type="EnsemblBacteria" id="AKH81234">
        <property type="protein sequence ID" value="AKH81234"/>
        <property type="gene ID" value="AA958_02525"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_02525"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.540"/>
    <dbReference type="OrthoDB" id="1746871at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006061">
        <property type="entry name" value="SBP_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01037">
        <property type="entry name" value="SBP_BACTERIAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH81234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="449" mass="48935" checksum="1EF4882EDAA86B81" modified="2015-07-22" version="1">MSGRHPPIPPPPADPRTTIPRPGRFDRRTLLRVSAAGAAATATGGLAAACGSAAGQGPGKVAIHGDNATWEAPLQAAGKALKATAGLQLVPEVIPSLESFEQIVKSSLRTNKTPDLLKYWSGYRLRDLARTGGIEDLSKQWESAESQGWVDPSLREAFTYGGRVYGLPMNLAYWVIFYNPEVFAEHRLGKPETWDDFLTACTRLKDNGITPLHGTTAGRWPAFIWFQEILSRQDPQFYDDLMNGRERYTDPRAERALRTIAGFFDKNWFTSMDVDHNNAAAAVVHGDIGMVACGTWLGGVFAGAGAKPGKTVDAFVLPMADPAARPCVIFESSAFAVTVKGPDKEEALKAAGGWLHPEVATAFAHGLSDGSPNPKVEPANAVIEGITRQSKDLWLLNRFWEQGPPELVESTVDDLAGMLIDPHSYRSGLRTMQERADEAWKVWREAEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N1M7</accession>
    <name>A0A0F7N1M7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Hyaluronidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_09820</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015822.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_09820"/>
    <dbReference type="EnsemblBacteria" id="AKH82480">
        <property type="protein sequence ID" value="AKH82480"/>
        <property type="gene ID" value="AA958_09820"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_09820"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2069"/>
    <dbReference type="OrthoDB" id="1158117at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016231">
        <property type="term" value="F:beta-N-acetylglucosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011496">
        <property type="entry name" value="Beta-N-acetylglucosaminidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015882">
        <property type="entry name" value="HEX_bac_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02838">
        <property type="entry name" value="Glyco_hydro_20b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07555">
        <property type="entry name" value="NAGidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="SSF55545"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002518962" evidence="4">
        <location>
            <begin position="26"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="5">
        <location>
            <begin position="914"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="21"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="922"/>
            <end position="957"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH82480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="1051" mass="110828" checksum="FD4D2FC611C05320" modified="2015-07-22" version="1">MATATALSAAVIGGLLGGRAPEAAAQPQQPDAGGTESAETPAAEEALRDAVWPRPQQLRARAGEVHAGGQAVLVTPEDADSRALAELHEVLRAVGVREFTQVRPGAALPATGLVVYADQSPAGAAGVAGPAPRRSPADAALRALGAGEQADLPAGGYRLAAGQHEGRDIVALAGTDAEGLFHGVQTLRELARAARTENTLPAVSVRDWPGTAVRGIAENHYGRPWSHEQRLAQLDFMGRTKLNRYLYSPGDDQYRQAGWREAYPAEQRARFRELAERARANHVTLAWAVAPGQDFCFSSARDRKDLLAKADAMWALGVRAFQLQFHDVSYSEWACGEDADEYGSGPEAAARAQAETANALAAHLSRRHPYAAPLSLLPTEYYQDGTTDYRSALAGELDERVEVAWSGVGAVPREISGGQLRDNQAAFGGHPLVTQDNYPVNDYARDRIFLGPYDGRDPAVAAGSAGVLAGAMEQPAASRVPLFTVADYAWNPRAYDPDASWRAAVRDLAADAPDPEKAGAALAALAGNSASSELGARESAYLRPLIADFWRERESAAGGRRDGEKAAARLREAFTVMRRAPEDLAPLADGTFGDEVRPWLTQLARYGAAGERAVDMVTAQAAGRNEEAWQARLELQRLAGDAVPHSAPGRAWAVPPGGGVVGAGVLDAFLSRALTDSDSWLGAGGGAGAAVSGGAEPLEGSSVAAAADGKPATAYEAARPPSPGTHEALVVEFDRRPLRAVTVLTQPGTGTRAEVQIRVRDGGGTAWRPVGELDGGGWTELPAERADADAVRFVWAADTTAPVVHEVVPWSAAEPGARLSLSRDEADVTIGGDPVVVDAELSARRPGDAGGTVTAKAPEGLKARAPGEVRIARGTTARAPVEIRATEDVPPGTYEIPVKLEDGGAAQVRTVTVHAYPAVGGPDLARDGRASSSADETPDFPAAAVADGDPETRWSSPAEDGAWVQMRLAKPVRVGEVALHWESAYAKRYRVQVSADGRRWRTAAAVNDGGGGRESVRMDEREVRYVRVQGVERATEFGYSLYALEVRAVRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2A1</accession>
    <name>A0A0F7N2A1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphatidylinositol kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_04130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014869.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_04130"/>
    <dbReference type="EnsemblBacteria" id="AKH81514">
        <property type="protein sequence ID" value="AKH81514"/>
        <property type="gene ID" value="AA958_04130"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_04130"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.867"/>
    <dbReference type="OrthoDB" id="1421354at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022292">
        <property type="entry name" value="CHP03843"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03843">
        <property type="entry name" value="TIGR03843"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="306" mass="31537" checksum="BA9D6F734771731F" modified="2015-07-22" version="1">MSAPERIPPGGVSPLALASDEARALLTGGELTVAGRIRGASNAVLFCTVAHAGRTAECVYKPVAGERPLWDFPDGTLAQREAAAYEVSEATGWGLVPPTVLRDGPFGEGMCQLWIPAADERHATDAQDGTGGQDGQGGTAGAAPGGTDLLALVEGDEPGPGWKAVGYAETGEGRPALLVHADDVRLRRLAVLDAVINNGDRKGGHLLPAAGGRLYAIDHGVTFHTDDKLRTLLWGWAGEPLPAEAVAVLHRLAAGLAPEGPLAARLAPLITAAEVAALRARIAALLASGRHPEPSGEWPAIPWPPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2G6</accession>
    <name>A0A0F7N2G6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_01470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014417.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_01470"/>
    <dbReference type="EnsemblBacteria" id="AKH81052">
        <property type="protein sequence ID" value="AKH81052"/>
        <property type="gene ID" value="AA958_01470"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_01470"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.323"/>
    <dbReference type="OrthoDB" id="1024978at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="2">
        <location>
            <begin position="9"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH81052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="443" mass="45888" checksum="AF2A89813B4CC1C8" modified="2015-07-22" version="1">MLGEYRIEGRGAAEISASIERGIGAGALQPGAPLPPLRALAAELAVNPNTVAAAYRMLRERGVVETAGRRGTRVRARPATSPREQISVAVPPGARDLSTGNPDPALLPPLAGALAAAAARHAAAPVLYGDEGVAPELARLARADFDADGVPPGPVAVTSGSLDAIERALAAHLRPGDAVAVEDPAWGSLLDLVPALGLRPVPVELDDEGPLPERAAAALASGSRALVVTSRAQNPTGAALTPARADELRAVLARHPDVLLVEDDHGHAIVDLPFQPLAGAARHWLAVRSAAKAYGPDLRLAVLTGDRVTVDRVEGRQRLGPGWVSRLLQDTVVHLRSSGVLDPAAVARSYGERREALLAALRGRGVEATGRSGMNVWLPVPDETSAVTQLLRSGWAAAPGARFRLASPPGIRLTVSPLAGEDVEPLADAVAEAVRPGPGRRWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2G8</accession>
    <name>A0A0F7N2G8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA polymerase subunit sigma24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_11935</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016161.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH82825">
        <property type="protein sequence ID" value="AKH82825"/>
        <property type="gene ID" value="AA958_11935"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_11935"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2510"/>
    <dbReference type="OrthoDB" id="1914729at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r4_2" evidence="6">
        <location>
            <begin position="150"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH82825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="210" mass="22959" checksum="C205AD8D147F849C" modified="2015-07-22" version="1">MKRTRPGARPVPAQSRPSVPPTHAGAGAPADRTDRNPADGAQPLTASADLDREAAIARLFDLHYTPMLRLAALLGADDPENIVAEAYYQIYRKWRKIRATDSAEAYLRSVVCNLTRMRIRHLQAARRHVEVPVGSVASAETSALLHDDQRALVSALQQLPARQREALVLRHWLGLKEGEIAQTMGISSGSVKTHTARGIAALTQALEARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2P3</accession>
    <name>A0A0F7N2P3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cyclohexanone monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_12190</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016205.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_12190"/>
    <dbReference type="EnsemblBacteria" id="AKH82870">
        <property type="protein sequence ID" value="AKH82870"/>
        <property type="gene ID" value="AA958_12190"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_12190"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2564"/>
    <dbReference type="OrthoDB" id="630753at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="490"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH82870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="512" mass="56115" checksum="D5D51474C210C66C" modified="2015-07-22" version="1">MTREHVRVAVIGSGFGGLGAAVRLRREGITDFVVLERASTLGGTWRDNSYPGCACDVPSHLYSFSFAPNAEWPRTFSGQRHIRDYLEQVADVFGIRQHIRFDHEVRAIRWDDDELRWEIDTARGELAADVVVSATGPLSDPKVPDIPGLDTFPGKVFHSARWDHDVPLGGKRVAVVGTGASAIQIVPSIQPEVSRLTVFQRTPPWVLPRVDRAISGPERWLHARVPATAKLRRGILWGIRELQVGAFTKHPHELGFVEGLAKRNLGRAIKDPELRRKLTPGYRIGCKRILLSNDYYPALAQPNVDVVASGLKEVRGSTLVAADGTGTEADAIIFGTGFHVTDMPIADRIKGRDGTTLAEAWSGGMEALRGASAAGFPNLLTIIGPNTGLGNSSMILIIEAQLTYMADFVRQLGRLGKPGGRVALDARPSAVKQWNARVQERMKRTVWNTGGCDSWYLDANGRNTTVWPGTTTEFRRVTRRVHPEEYEVLRTGGGVPGARQSGAARHGEEAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N349</accession>
    <name>A0A0F7N349_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GTPase Obg</fullName>
            <ecNumber evidence="6">3.6.5.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">GTP-binding protein Obg</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">obgE</name>
        <name evidence="11" type="synonym">cgtA</name>
        <name evidence="6 11" type="synonym">obg</name>
        <name evidence="11" type="synonym">yhbZ</name>
        <name evidence="11" type="ORF">AA958_09525</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="6"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015770.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_09525"/>
    <dbReference type="EnsemblBacteria" id="AKH82426">
        <property type="protein sequence ID" value="AKH82426"/>
        <property type="gene ID" value="AA958_09525"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_09525"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2008"/>
    <dbReference type="OrthoDB" id="603226at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01898">
        <property type="entry name" value="Obg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.210.12">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01454">
        <property type="entry name" value="GTPase_Obg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014100">
        <property type="entry name" value="GTP-bd_Obg/CgtA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036346">
        <property type="entry name" value="GTP-bd_prot_GTP1/OBG_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006074">
        <property type="entry name" value="GTP1-OBG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006169">
        <property type="entry name" value="GTP1_OBG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036726">
        <property type="entry name" value="GTP1_OBG_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045086">
        <property type="entry name" value="OBG_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015349">
        <property type="entry name" value="OCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11702">
        <property type="entry name" value="PTHR11702"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09269">
        <property type="entry name" value="DUF1967"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01018">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102741">
        <property type="entry name" value="SSF102741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82051">
        <property type="entry name" value="SSF82051"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02729">
        <property type="entry name" value="Obg_CgtA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03595">
        <property type="entry name" value="Obg_CgtA_exten"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00905">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51883">
        <property type="entry name" value="OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51881">
        <property type="entry name" value="OCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Obg" evidence="10">
        <location>
            <begin position="2"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="OBG-type G" evidence="8">
        <location>
            <begin position="160"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="OCT" evidence="9">
        <location>
            <begin position="348"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="62"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="442"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="443"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="166"/>
            <end position="173"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="191"/>
            <end position="195"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="212"/>
            <end position="215"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="282"/>
            <end position="285"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="311"/>
            <end position="313"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AKH82426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="481" mass="50981" checksum="A76A616757536A76" modified="2015-07-22" version="1">MTTFVDRVTLHVAAGNGGHGCASVHREKFRPLGGPDGGNGGHGGDVILTVDQNVTTLIDYHHTPHRKATSGKPGEGGDRAGANGKDLVLPVPDGTVVLTKDGEVLADLVGHGTTFVAAQGGRGGLGNAALASQRRKAPGFALLGEPGTARDVVLELKTVADVALVGYPSAGKSSLISVVSAAKPKIADYPFTTLVPNLGVVTAGAVTYTIADVPGLIPGASEGRGLGLEFLRHVERCSVLVHVLDTATLESDRDPVSDLDVIEEELRAYGGLDDRPRVVVLNKIDIPDGRDLAEMVRPDLEARGFTVYEVSAVARTGLKELSYGLAGIVGEARAARPKQESTRIVIRPQAVDEAGFSVVREGGDADGALFRITGEKPERWVRQTDFGNDEAVGYLGDRLNRLGVEDRLRKAGAKPGDDVVIGTGEDAVVFDWEPAMASGAEMLGRRGEDHRFDTPRPAAQRRRERDAERAEEEYEDFDPFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N354</accession>
    <name>A0A0F7N354_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Radical SAM protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_09550</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015775.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_09550"/>
    <dbReference type="EnsemblBacteria" id="AKH82431">
        <property type="protein sequence ID" value="AKH82431"/>
        <property type="gene ID" value="AA958_09550"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_09550"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2013"/>
    <dbReference type="OrthoDB" id="1514287at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018768">
        <property type="entry name" value="DUF2344"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10105">
        <property type="entry name" value="DUF2344"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03936">
        <property type="entry name" value="sam_1_link_chp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2344" evidence="2">
        <location>
            <begin position="3"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH82431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="260" mass="27536" checksum="02A3BBD18CEE6F83" modified="2015-07-22" version="1">MQRIRLRYTKRGRLRFNSHRDFQRAFERALRRAEVPMAYSAGFTPHPKVSYANAAPTGTASEAEYLEIALAEARDPELLRALLDESLPDGLDVVDAVEARAPGLADRLGASVWELRLDGVPPATAQEAVRAFLAAETVEVERQTKKGMRTFDTRGAVAALDVLPAGGDRPQAGPCAILRLVVRHLTPAVRPDDVLSGLRVAADLAPPVPAAVTRLAQGPLDAETGMVTDPLAPDRDDAAALAATPQVASGTPPTAGDGTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N396</accession>
    <name>A0A0F7N396_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ROK family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_09850</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ROK (NagC/XylR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015828.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_09850"/>
    <dbReference type="EnsemblBacteria" id="AKH82486">
        <property type="protein sequence ID" value="AKH82486"/>
        <property type="gene ID" value="AA958_09850"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_09850"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2075"/>
    <dbReference type="OrthoDB" id="1130699at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="2">
        <location>
            <begin position="13"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH82486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="401" mass="41102" checksum="C754BC12045A9614" modified="2015-07-22" version="1">MAGGPGTLRAMNDRAALELLLEHGTLSRTRLGKLTGLSKPTASQLLARLEAAGLVLATGTSEGSPGPNAQLYALNPAVAHVVGLDVTAARIRAAVADVTGRTVGSYELATAKRTGGGAAEGTVRRVVRAVDGAAKDAGLTRAELHRAVIGTPGAFDPGTGRLRYASHLPGWHSPTLLEELAAALPMPLACDNDVNLAAVAEQRRGAARGHDDFVLLWNEEGLGAAVVIGGRLHRGGTGGAGEVGFLPVPGATLVRQVTRANSGGFQELAGAQALAPLARELGLTPGRGHYAEVAADLVARAAAEPEEPGHAELLDRYAERLAVGLASVVAVLDPQLIVLSGAVLTAGGDRLRALVQSELAELAAPRPRLVTGEVERHPVLTGALESALATTRDEVFDTTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3K1</accession>
    <name>A0A0F7N3K1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cysteine synthase</fullName>
            <ecNumber evidence="9">2.5.1.47</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">cysM</name>
        <name evidence="9" type="ORF">AA958_10735</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cysteine synthase/cystathionine beta-synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.47" evidence="9"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015962.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_10735"/>
    <dbReference type="EnsemblBacteria" id="AKH82621">
        <property type="protein sequence ID" value="AKH82621"/>
        <property type="gene ID" value="AA958_10735"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_10735"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2258"/>
    <dbReference type="OrthoDB" id="1033353at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004124">
        <property type="term" value="F:cysteine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005856">
        <property type="entry name" value="Cys_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001216">
        <property type="entry name" value="P-phosphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01136">
        <property type="entry name" value="cysKM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00901">
        <property type="entry name" value="CYS_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="4 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PALP" evidence="8">
        <location>
            <begin position="9"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="6">
        <location>
            <begin position="176"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR605856-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR605856-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH82621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="316" mass="33796" checksum="8E0E1065EAD8C3F9" modified="2015-07-22" version="1">MRYESTLAAVGDTPLVHLPRLSPAPDVRIWAKLEDRNPTGSVKDRPALFMVEQAEKDGRLTPGCTILEPTSGNTGISLAMAAKLKGYRIVCVMPENTSAERRQLLAMWGAEIISSPAAGGSNTAVRVAKELAAEHPDWVMLYQYGNPGNAGAHYATTGPEILADLPSITHFVAGLGTTGTLMGAGRFLREHRPGVQIVAAEPRYDDLVYGLRNLDEGFVPELYDESVLTTRYSVGSEDAVTRTRELLREEGIFAGVSTGASLHAAIGVGRKAVRAGESSDIAFLVADGGWKYLSTGIYTAETTEEAVAALHGQLWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3K3</accession>
    <name>A0A0F7N3K3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_06775</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015316.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_06775"/>
    <dbReference type="EnsemblBacteria" id="AKH81964">
        <property type="protein sequence ID" value="AKH81964"/>
        <property type="gene ID" value="AA958_06775"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_06775"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1416"/>
    <dbReference type="OrthoDB" id="1514411at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH81964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="413" mass="43828" checksum="A07F4F69F2C72E88" modified="2015-07-22" version="1">MAGVRRTVVLVLCAGLVAALLGGCGRDGRGGGDGEPRDATRAIADLLRQRSAAVRDGDEAAYLRTVDPHSGPYRQRQRTVFRNLDALPLAAWTLRLDDPARATVPATAERTTADVRLAYRLRGYDTGDATAGQRLEFVRRDSRWYVAGPAPGSRPQPWDQGPLTVVRGTHSLVLGAGQSGARLRGIAAVADRAVPDVSAAWGGAWARRVVVVVPASQAAMGELLGAGPTDYAGVAAVTTGRHRDRTPADRVVVNPEAYGTLGTLGRRIVLTHETVHVATRADTSPATPLWLSEGFADWVAFRGTGRDPRQGAPELARAVAAGRLPDSLPADGDFTRPTGGDGDRVAEAYGEAWLAARMVADEWTPDDLVALYRAVGGAKSRDKAVGPALRAELGASLTEFTARWRTYLDHELG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3S3</accession>
    <name>A0A0F7N3S3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_07095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015374.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH82024">
        <property type="protein sequence ID" value="AKH82024"/>
        <property type="gene ID" value="AA958_07095"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_07095"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1487"/>
    <dbReference type="OrthoDB" id="688156at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="21"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="353" mass="38757" checksum="33887C8D4E0B4E2A" modified="2015-07-22" version="1">MQAAVTVTPARIPELLLGLATVRPVFLWGAPGIGKSSLVRQFADSLGLDCVSLIGTQLAPEDLIGVPQIRDGRSVFCPPEAIARDEAYCLFLDELNAATPDVQKAFYSLILDRRIGTYELPEGSIVIGAGNRATDNALARPMASALVNRLAHVHLEASATDWLVWAGEHGIHPWVTDYLTDRPDHLWAKPPKTEEPFSTPRSWHMLSDALHSFGPALDDVTLKTVAHGTLTPAHAVSFCGYVKIVRHRYGVEAILKGDASWPRRTEDRDLLYYLAEAFRGRLVKELPASKEHASPAVRETAYRAKALLVQLAEISVEVAQTVIAEDADGQPVLPAWFLVEAARDMPRLVEARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3V2</accession>
    <name>A0A0F7N3V2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_15135</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016644.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH83330">
        <property type="protein sequence ID" value="AKH83330"/>
        <property type="gene ID" value="AA958_15135"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_15135"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3189"/>
    <dbReference type="OrthoDB" id="1732721at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH83330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="132" mass="13769" checksum="BD111D845E43D4CB" modified="2015-07-22" version="1">MIILDTGAVKALAAGHKALNLLAGNMANTPGDQLRIPALCLMRAEADEERLHRRVLAFSSVVVDPLDTMAAASVGSMIRDGYGASDTCHALYCALPRAEFTGMSTLLTGGEGHYPPGVVTVDIDSPGMLGFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3Z8</accession>
    <name>A0A0F7N3Z8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glucose dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_04490</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the DapA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014927.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_04490"/>
    <dbReference type="EnsemblBacteria" id="AKH81572">
        <property type="protein sequence ID" value="AKH81572"/>
        <property type="gene ID" value="AA958_04490"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_04490"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.947"/>
    <dbReference type="OrthoDB" id="1438588at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020625">
        <property type="entry name" value="Schiff_base-form_aldolases_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="PTHR12128"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00666">
        <property type="entry name" value="DHDPS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0704">Schiff base</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR001365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH81572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="309" mass="32732" checksum="46BB3FFC7124582E" modified="2015-07-22" version="1">MTRPTHLTGVVPPVCTPLTPDAEVDTASLIRLVDFLVAGGVDGLFVLGSSSEAAYLRDEQRRAVVDTVVRHVGGQLPVLAGAIDMTTPRVLDHARSALDAGADALVVTAPFYTRTHPAEIDRHFREVAGRTGAPVYAYDLPVSVHTKLGHDLVLRLAADGVLAGLKDSSGDETGLRRVIVGVRDKVAGFSALTGSETMVDSALAMGAHGVVPGLGNVDPHGYVRLFRSAREGDWESARTEQERLLALFGMVRSGDPARMGMSSSALGAFKAALHLRGVIDCPATMLPQIPLDTEEVRRVEKHLAAAGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N448</accession>
    <name>A0A0F7N448_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribonuclease VapC</fullName>
            <shortName evidence="6">RNase VapC</shortName>
            <ecNumber evidence="6">3.1.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Toxin VapC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">vapC</name>
        <name evidence="8" type="ORF">AA958_07745</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Toxic component of a toxin-antitoxin (TA) system. An RNase.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the PINc/VapC protein family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="6"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015494.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_07745"/>
    <dbReference type="EnsemblBacteria" id="AKH82144">
        <property type="protein sequence ID" value="AKH82144"/>
        <property type="gene ID" value="AA958_07745"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_07745"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1629"/>
    <dbReference type="OrthoDB" id="1968541at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00265">
        <property type="entry name" value="VapC_Nob1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022907">
        <property type="entry name" value="VapC_family"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0800">Toxin</keyword>
    <keyword evidence="1 6" id="KW-1277">Toxin-antitoxin system</keyword>
    <feature type="domain" description="PINc" evidence="7">
        <location>
            <begin position="6"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH82144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="139" mass="15109" checksum="62B5D88EA3B5E974" modified="2015-07-22" version="1">MTVTHLIDTSAAVRILTDSGVRQRWRDHLAQGVIAMCDITQLELLYSARSLADRLHMHEQIRTLFNGAPTPDATFGRAHAVQLRLTEKGTHRSAGAVDLALAAVAELSGLILLHYDRDFEAVADATDLKAVWVAAPGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4L6</accession>
    <name>A0A0F7N4L6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha-glucosidase</fullName>
        </submittedName>
    </protein>
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    </gene>
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        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_08800"/>
    <dbReference type="EnsemblBacteria" id="AKH82309">
        <property type="protein sequence ID" value="AKH82309"/>
        <property type="gene ID" value="AA958_08800"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_08800"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1854"/>
    <dbReference type="OrthoDB" id="1573900at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DUF3459"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
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    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11941">
        <property type="entry name" value="DUF3459"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="3">
        <location>
            <begin position="27"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH82309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="563" mass="60920" checksum="CD2D00EBD66EC475" modified="2015-07-22" version="1">MTQHLAARTATDSAADLDWWRDAVIYQVYPRSFADGDGDGTGDLPGIRARLPYLAKLGVDAVWLSPFYASPQADGGYDVADYRAIDPVYGTLHDADALIRDAHELGLRIIVDVVPNHSSDRHEWFRRALSEGPGSPLRARYHFRPGKGANGELPPNDWESIFGGPAWTRVPDGEWYLHLFAPEQPDFDWEHPAVADEFRSILRFWLDMGVDGFRVDVAHGLVKAAGLPDVGGTGQLGLLGNAAMPFFDQDGVHDIYRSWRRVLEEYPGRRIAVAEAWTPTVERTANYVRPDELHQAFNFQYLGTYWDAAELRPVIDASLAAMRPVGAPATWVLSNHDVTRHTTRFANPAGLGTQLRSAGDPVRGLRRARAATLLMLALPGSAYLYQGEELGLPDVTDLPDEVRQDPAFARGAGQDGFRDGCRVPIPWTVTGSSYGFGDGGSWLPQPAGWGELSVEAQTGTPGSTLELYRTALAVRRAHPALGAGDAVEWLPAPDGVLLFRRTSGDAAFVCAANTTGAPVRITVPAGRLLLASAEQAGGEPGSPGGGEVELPADTTAWWSAGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-12-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4M3</accession>
    <name>A0A0F7N4M3_9ACTN</name>
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        <submittedName>
            <fullName evidence="9">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AA958_16860</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
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        </lineage>
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    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH83605">
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        <property type="gene ID" value="AA958_16860"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_16860"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3547"/>
    <dbReference type="OrthoDB" id="1677723at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010211">
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    </dbReference>
    <dbReference type="InterPro" id="IPR015358">
        <property type="entry name" value="Tscrpt_reg_MerR_DNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30204:SF0">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00376">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09278">
        <property type="entry name" value="MerR-DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
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        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
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        <location>
            <begin position="10"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="135"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH83605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="170" mass="19291" checksum="0FEC6740DA42E0C5" modified="2015-07-22" version="1">MDKPPFDAKELTVGQLAARSGVAVTALHFYEGKGLIRSRRTPGNQRRYTRDTLRRVAFIRTAQRVGIPLRTVAEALRTLPDERTPTQEDWARLSAAWRDELDIRIDQMVRLRDRLTDCIGCGCLSLERCLLRNRDDRLGDTGPGPRRLLTRRLAQETRVPPAGKEDGEGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4M8</accession>
    <name>A0A0F7N4M8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH82951">
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        <property type="gene ID" value="AA958_12760"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_12760"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2681"/>
    <dbReference type="OrthoDB" id="1950120at2"/>
    <dbReference type="Proteomes" id="UP000034283">
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="EMBL" id="AKH82951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="109" mass="11632" checksum="4A6E5BC85F0F7873" modified="2015-07-22" version="1">MGPMKKIPGQRSPVECARALDQALEAQRARTALVRAIKNGEVDCVQALERAARDALAGDMLAKDFLLALPGVGPAQTAKLMTKLGLSDTRRLRSLAPVQRELIGAAVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4P2</accession>
    <name>A0A0F7N4P2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_16950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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    </dbReference>
    <dbReference type="RefSeq" id="WP_047016924.1">
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    </dbReference>
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        <property type="gene ID" value="AA958_16950"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000034283">
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="234" mass="24999" checksum="9B2969BCE458C721" modified="2015-07-22" version="1">MPGLTEAEEARLRRALGLIAAEAEGAREGGTASGDWGWTEPSPGVRRVRGARRALAAVVSAAAVVAFCLLAYTTISGAGTDRIAKDDAGAGAAEDAGVDAGGDADGKGLSRLQNAACTKRLLEGTVADVQQVPHPPDAFPWVEVTLTDVRWHVPPSTERQVTVRLPDPVEWNAEKPFARGEPLLVEDLGRHDISYFRDGPGKGRGLETVREERLRALDKAQEKGVTCPSFWKNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4Q0</accession>
    <name>A0A0F7N4Q0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_09170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015714.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH82368">
        <property type="protein sequence ID" value="AKH82368"/>
        <property type="gene ID" value="AA958_09170"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_09170"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1934"/>
    <dbReference type="OrthoDB" id="1437290at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041478">
        <property type="entry name" value="TetR_C_27"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17935">
        <property type="entry name" value="TetR_C_27"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="5"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH82368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="234" mass="24335" checksum="AD1C51494A8ADF52" modified="2015-07-22" version="1">MPSETLTPEHILEATEDVLRRYGPAKATVVDVARVLGVSHGSVYRHFPSKAALHAAVAARWLDRTSAALEKVSAAEGPADVRLRRWLAELFDAKRHKAHDDPEMFATYMALIGDGASAGRAGPAAAGAAGAAGSATVAGVVARHVAELTGQLTLILEDGVRQGVLSVPPAVAAGDAEAAAVAQAARRSVEGVARAVFDATRRFHDPAFAADWEEPGVAAEFALVVDVVVRGLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N509</accession>
    <name>A0A0F7N509_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_17690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017037.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_17690"/>
    <dbReference type="EnsemblBacteria" id="AKH83735">
        <property type="protein sequence ID" value="AKH83735"/>
        <property type="gene ID" value="AA958_17690"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_17690"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3725"/>
    <dbReference type="OrthoDB" id="1719670at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010419">
        <property type="entry name" value="CO_DH_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38588">
        <property type="entry name" value="PTHR38588"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH83735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="303" mass="31314" checksum="7060E13270D570C8" modified="2015-07-22" version="1">MHVPQPAETVRRALSDAVRVARSVPGLTLDEDGAEEPGTLRGRLRLRVAGSSITYRGTLRLTPGGPSVAVEAEGEESRGSGTVTVSLALTPREAVEEGTATLLCTGTVASTGRLAAVEAGQAQAAGVRLLERFAESLAADLEAEPLAEEPAGEPEHPDDAVQPGDGTDAGIGDDNERAIPGIPAPEHSGETPPGTGKVFDAEVPPPSLDPLADDVLDALADEEEDADEPVDDLLEEPEAAHARRTMIGRSAEEVDHAPPRGRYAPTPAADAPAQAAGLRWLAPAAALAVATAVILSRALRRRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N511</accession>
    <name>A0A0F7N511_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_09885</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_09885"/>
    <dbReference type="EnsemblBacteria" id="AKH82493">
        <property type="protein sequence ID" value="AKH82493"/>
        <property type="gene ID" value="AA958_09885"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_09885"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2081"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031634">
        <property type="entry name" value="PknG_rubred"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031636">
        <property type="entry name" value="PknG_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16919">
        <property type="entry name" value="PknG_rubred"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16918">
        <property type="entry name" value="PknG_TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="86"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="378"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH82493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="751" mass="80662" checksum="D2DBCAF91497861E" modified="2015-07-22" version="1">MASRGKLGAGLVSVPEVPRPDPRTAVLANPEVPERKRYCSRSECGAPVGRSRGGRPGRTEGFCTKCGQPYSFVPKLQEGDIVHGQYQVAGCLAHGGLGWIYLAIDRAVADRWVVLKGLLNTGDEDAIAAAVSERRFLAEIEHAGIVRIYNFVEHLDQRTGSLDGYIVMEYVGGKSMKEIANERRTPDGKRDPLPVEVACAYGIEALEALGHLHSRNLLYCDFKVDNAIQQGDQLKLIDMGAVRRMDDDESAIFGTVGYQAPEVAEVGPSIASDLYTVARTLAVLTFDFQGYTNVFVDTLPDPDSIDVFNRYESFYRLLVRATDPDPARRFASAAEMSEQLTGVLREVVALQTGKPQPALSTLFGAELRVVDTELFPPATGETSQLGARPVSKRERTARAAGKGVPALPPAQGVPPQLPGGGPGMGTQVALPAQIADTLPLDSPAAALALPVPRVSPSDPNAGFLAGLMASAPAELTAALANAPTDSIELQLRRVRAHLELGDLAATGSALAELGEQHPDDWRIVWYRGLQALATRDFETAALSFDAIYDAFPGEPAPKLALGICAEVLGQLDNATEYYRLVWTTDPAYVSAAFGLARVRLAAADRSGAVRALESVPEASIHYTAARVAAIRARLRQRAPQEPLLTDLQAAGTQVERLQDVGLDAGRRARLATEVLGSALDWVLTGRTGAGQHPAAPAGPPQQPLLGCTLDEDGLRLGLENSFRVLARLAQHGHERIDMVERANRYRPKTWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N569</accession>
    <name>A0A0F7N569_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NodB homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_10155</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015871.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_10155"/>
    <dbReference type="EnsemblBacteria" id="AKH82529">
        <property type="protein sequence ID" value="AKH82529"/>
        <property type="gene ID" value="AA958_10155"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_10155"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2138"/>
    <dbReference type="OrthoDB" id="1701876at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="2">
        <location>
            <begin position="103"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH82529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="286" mass="31491" checksum="97084B86E28CC15A" modified="2015-07-22" version="1">MKYDKYPTRGVSRRTAFCLGLLGAYQLALAPDAHAPRSGTAAVRTGLADGKPLRRPSYGLRPAAGRTGTAPMTTSGGMARIVGPTRPVAVRAAAHTTLRETGKKIALTFDDGPHATQTPEILRILRRHGARATFFVIGENIPWNRDVLRRIAAEGHVVGNHSYTHPQLDLISTPRVRAELEQTCELVARELGAPPRVARAPYGRWHGPSLEICAQLQMEPFQWDIDTLDWDHRDQAFIEKTVLRKAHAGAIVLAHDGGGNRWATVRALEYYLPRLLDEGYTLVHPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5D5</accession>
    <name>A0A0F7N5D5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-hydroxyhepta-2,4-diene-1,7-dioate isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_10695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015955.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_10695"/>
    <dbReference type="EnsemblBacteria" id="AKH82614">
        <property type="protein sequence ID" value="AKH82614"/>
        <property type="gene ID" value="AA958_10695"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_10695"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2250"/>
    <dbReference type="OrthoDB" id="775108at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="SSF56529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAA_hydrolase" evidence="1">
        <location>
            <begin position="75"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="285" mass="30192" checksum="CD87FA4C3FEEF31F" modified="2015-07-22" version="1">MKLLRVGPPGSERPALLDDGGTLRDLSGVVSDVDGALLSDDAALARVRDADAAGDLPALDAEGLRTGPPVAGIGKIVCIGLNYHDHAAETGAAIPAEPILFMKAPDTVVGPEDTVLVPRGSEKTDWEVELAVVIGRTARYLESDADALAAVAGYAVAHDVSEREFQLERGGQWDKGKNCETFNPLGPWLVTADEVPDPQALGLRLWVNGEKRQDGTTADQIFPVAHVVRYLSRFMTLYPGDVINTGTPAGVALGMAEPKPYLRAGDVVELEVDGLGRQRQEIKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5E4</accession>
    <name>A0A0F7N5E4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RDD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_10780</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015969.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_10780"/>
    <dbReference type="EnsemblBacteria" id="AKH82629">
        <property type="protein sequence ID" value="AKH82629"/>
        <property type="gene ID" value="AA958_10780"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_10780"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2267"/>
    <dbReference type="OrthoDB" id="1974702at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010432">
        <property type="entry name" value="RDD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06271">
        <property type="entry name" value="RDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="242"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="RDD" evidence="7">
        <location>
            <begin position="236"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="76"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="119"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="193"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH82629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="384" mass="37947" checksum="B1FE6D8E8E3F1EF3" modified="2015-07-22" version="1">MSSDHGEGADPHRSKPTRSQPPQSGAPPGGTRGQEGQEEEAGPPPGEDHGAREPREAPAAGSGTTRPVGRPTTPEEQGEAPPPPAGPAPGTGEGTPAHGGGGQGPGGAPPPPTGPGAMPSSGSGVTPPTGPGASSSSGSGTAPPTGPDAAPSSGSGVTPPPGPGGSSPSGPGAAPPPGSGTGGEHGYGPPPSGGSPYDQPPGSMPPPPPPPPYGGGPGGSPYGAPDPRLAGMPPLGGLGRRLLARIIDALIVYIPVSLFLTLIGRVDEVADTDNTGSQYAWGIFGILVYLVYEGLMLTRSGQTVGKKLMGIRVGMLENGAVPAGGPGWLRAAVYSLPAIVPCIGTLFWLYNVLSCTWDRPYRQCVHDKAAKTVVVSTEGQRYTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5J5</accession>
    <name>A0A0F7N5J5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha-glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_11060</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016017.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_11060"/>
    <dbReference type="EnsemblBacteria" id="AKH82679">
        <property type="protein sequence ID" value="AKH82679"/>
        <property type="gene ID" value="AA958_11060"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_11060"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2329"/>
    <dbReference type="OrthoDB" id="469334at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025887">
        <property type="entry name" value="Glyco_hydro_31_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13802">
        <property type="entry name" value="Gal_mutarotas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gal_mutarotas_2" evidence="3">
        <location>
            <begin position="165"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH82679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="761" mass="83472" checksum="47052AAD8DF0CD1E" modified="2015-07-22" version="1">MKFTDGYWMLRSGVRAAYPVEVLDVTAGDGTLDVHAPTQPIRHRGDLLKGPVMTVSVHSPLPDVIGVTLTHFDGGTDAGPRFHIAGAESHAQVSYDDEHALLTAGSLALRVARGGPWQLDFLTADGLKPLTSSGPKGMAIMETDAPGGGPARHYLREQLGLGVGTHVYGLGERFGPLVKNGQVVDIWNADGGTATEQAYKNVPFYLTDAGYGVFVDHPGRVSLEVGSEAVSRVQFSVEGQELTYYVIHGPTPKEILRKYTALTGRPALPPAWSFGLWLSTSFTTSYDEETVTSFIDGMAERDLPLSVFHFDCFWMREFHWCDFEWDPRVFPDPAGMLRRLKERGLKICVWINPYIAQRSPLFAEGRDAGYLLRRPDGGVWQWDLWQPGMALVDFTNPDARAWYAGKLAALLDMGVDCFKTDFGERVPTDVAYFDGSDPERMHNYYTYLYNETVFDVLKKHRGEGEAVVFARSATAGSQQFPVHWGGDCESTYEAMAESLRGGLSLGMSGFGYWSHDIGGFEGTPSPALFKRWIAFGLLSSHSRLHGSSSYRVPWLFDEEAVDVLRVFTKLKLRLMPYLDAVAREAHEQGVPMMRPMALEFPDDPACTHLERQYMLGPDLLVAPVFNDEGEVSYYVPEGAWTHLLSGEEVHGPRWVRERHGFASAPVLVRPGAVLPVGSVDDRPDYDYADGVTLRAYGLRPGQRVAVPVGGTTFTVVCEGDTVRASAGGDPAGAGKPWALEVVGGPTVRAEAGRGVVVAELG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5N0</accession>
    <name>A0A0F7N5N0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Puromycin resistance protein pur8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_18640</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017182.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_18640"/>
    <dbReference type="EnsemblBacteria" id="AKH83885">
        <property type="protein sequence ID" value="AKH83885"/>
        <property type="gene ID" value="AA958_18640"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_18640"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3909"/>
    <dbReference type="OrthoDB" id="1108236at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="102"/>
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</entry>
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</entry>
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                <person name="Kalinowski J."/>
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        </source>
    </evidence>
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</entry>
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                <person name="Leipoldt F."/>
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                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
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        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
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        <location>
            <begin position="31"/>
            <end position="220"/>
        </location>
    </feature>
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            <end position="201"/>
        </location>
    </feature>
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            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH83411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="220" mass="23283" checksum="685BFB9471343217" modified="2015-07-22" version="1">MRTTRTTTAYAAAALAAAAALTLTACGSGSDDDGAKPAVEISGGSKPGVVLDTPKEKPELVLTDTEGEEYDLVAETAGKPTLLFFGYTNCPDVCPTTMSDIAIAKQKLPRAEQDKLQVVMVSTDPERDTPKRMGKWLDAQDKDFIGLTGDFAAVKDAARSVGVHLEKPVKEKDGSITVSHGAEVLAYSPKDDKAHVLYLAGVTADQYAKDMPKLVKGQNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N631</accession>
    <name>A0A0F7N631_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sugar isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_19740</name>
    </gene>
    <organism evidence="3 4">
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
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    </evidence>
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    </evidence>
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</entry>
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            <authorList>
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
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    </dbReference>
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            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01402"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="AKH84060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="79" mass="9069" checksum="973E807F2094676D" modified="2015-07-22" version="1">MTVQTISFRPDATTRRELDALASMRDVTVSDAIRQAVHEAYVREQYRQAAAEVQEWRLDPAYAAEAAAVRQEMDDLRAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6A4</accession>
    <name>A0A0F7N6A4_9ACTN</name>
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        <submittedName>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
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    </dbReference>
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        <location>
            <begin position="52"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="119" mass="13207" checksum="16E17F9B3381C8F1" modified="2015-07-22" version="1">MLEVKTIEKPDERRDFPRGHLEAVHMTGLDFAVATFEPGWRWTESVKPLAGTETCMVHHNGYVVQGRMHILMDSGQESEVQAGDVFVCPPGHDAWVVGDEQVVLYDFAGAMATEYAKGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6F9</accession>
    <name>A0A0F7N6F9_9ACTN</name>
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        <name evidence="5" type="ORF">AA958_20820</name>
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    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
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    </dbReference>
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        <source>
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        </source>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AKH84230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
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        </source>
    </evidence>
    <sequence length="54" mass="6407" checksum="0DA4205FFD69A930" modified="2015-07-22" version="1">MAATDVRPKITLACVECKERNYITKKNRRNDPDRLEMKKHCPRCNAHTAHRETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N743</accession>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Albersmeier A."/>
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                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83881.1"/>
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    </dbReference>
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        <property type="protein sequence ID" value="AKH83881"/>
        <property type="gene ID" value="AA958_18600"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_18600"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3902"/>
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    </dbReference>
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        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
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        <property type="entry name" value="DUF664"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH83881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="172" mass="19184" checksum="E5E0904603AF2209" modified="2015-07-22" version="1">MSHVFERPPLLADEHTSLTGWLELQRRILRWKCEGLSEADAHRSVVPTSPLMTMAGLLVHMRWTEHAWLDVIFLGGDSSRNPAFDESAGEDADWSTAGVTLAQAVADYEAQCARSDEIIAAASLDDVARHPGFPRKRANLRWILTHLIEETGRHAGHADIVRELVDGTKGYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-12-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N748</accession>
    <name>A0A0F7N748_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_18650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017183.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH83886">
        <property type="protein sequence ID" value="AKH83886"/>
        <property type="gene ID" value="AA958_18650"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_18650"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3911"/>
    <dbReference type="OrthoDB" id="1928091at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH83886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="337" mass="35780" checksum="A5573B8431009C6A" modified="2015-07-22" version="1">MDILVLGGTAWVGREVSRLALARGHRVTCLARGESGGVADGAELVAADRRDPGAYDALPARTADRPWDAVVEVSWQPGFVRGALAALADVARHWTYVSSGNVYATHHRPGADESAPLMEPTDRDEVDRELYGEAKSACEQATRAAVGGDRLVIARAGLIGGPGDHTGRTGYWVARAARDPESPMLVPAGPHLSTQVVDVRDLVAWLLDNADSGRTGTYDTVGPVVSLDDWIRLSREVGGHTGPVAAAGSAWLRGQGVEQFMGAESLAMWLDEPGWEGFTSRSGAAAVAAGLTHRPRAQLLADTLAWEREQGLHRPRRAGLSPARERELLAALAEAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7H6</accession>
    <name>A0A0F7N7H6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_22765</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017812.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_22765"/>
    <dbReference type="EnsemblBacteria" id="AKH84555">
        <property type="protein sequence ID" value="AKH84555"/>
        <property type="gene ID" value="AA958_22765"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_22765"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4790"/>
    <dbReference type="OrthoDB" id="91172at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="SSF69318"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH84555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="231" mass="24793" checksum="3CD9FFC91E6FF334" modified="2015-07-22" version="1">MWINPNNGFGFACTTCSTTTYERQEMTVLEETNNHWKTGAKQILAVGDVDGPLDTDDDGEIDTPGYPDLLVNDGQHLWLYYGDPGGSAYLDAFRDPVLLAAGDGMSTGTNTLANVTMAAPGDFDADGHADLTVRFDNDGSGLFLYDAINPDASTWPGQIDPTHRILIANNFGPNTVPMLTAAPDANNNGTFDLWTTTPNSGRLRFFADFTPDGPVAITVASEQFANYQALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8M1</accession>
    <name>A0A0F7N8M1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Multidrug ABC transporter ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_18340</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017142.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_18340"/>
    <dbReference type="EnsemblBacteria" id="AKH83843">
        <property type="protein sequence ID" value="AKH83843"/>
        <property type="gene ID" value="AA958_18340"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_18340"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3853"/>
    <dbReference type="OrthoDB" id="1926714at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="9"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="309"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH83843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="334" mass="35644" checksum="AD02F23E0AAE9D24" modified="2015-07-22" version="1">MVSAEEDVISAAGLRRTYGDFEAVRGVDFAVRRGELFALLGTNGAGKTSTVELLEGLAEPSGGRVRVLGRDPYRERGRVRPYTGVMLQEGGMPSQLTVAETVRMWAGCTARPRPTAEALELVGLAGRRDVRVAQLSGGEKRRLDLALALLGRPEVLFLDEPTTGLDAEGRHATWELVRELRAGGTTVLLTTHYLEEAEELADRLAIMAGGRIAAAGTVEEIVGAHPATVSFRLPTGWLPGDLPPLPALGVTGHELAGTSVRLRTSALQRTLTGLLLWAQDNGVELAGLDARSASLEEAFLKIADAAVDDRGRGRSAPSAKRTADTVRTDERNAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8S2</accession>
    <name>A0A0F7N8S2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ser or Arg-related nuclear matrix protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_25005</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018176.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_25005"/>
    <dbReference type="EnsemblBacteria" id="AKH84925">
        <property type="protein sequence ID" value="AKH84925"/>
        <property type="gene ID" value="AA958_25005"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_25005"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5269"/>
    <dbReference type="OrthoDB" id="1063432at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002838">
        <property type="entry name" value="AIM24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036983">
        <property type="entry name" value="AIM24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016031">
        <property type="entry name" value="Trp_RNA-bd_attenuator-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01987">
        <property type="entry name" value="AIM24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51219">
        <property type="entry name" value="SSF51219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH84925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="238" mass="25004" checksum="25A6493D1DCA4A1B" modified="2015-07-22" version="1">MTAGPVVHDMNTLPRNDNVHPYAFSVALDGQWFLQKGKMIAYYGQISFEGVGHGAFDGLVAGSFHSPLHAADWVVARGSGVMVLADRAFDVNSFDLDDGNLTIRSGNLLAFEPGLELKQSIVPGFLTLIGTGKFVAVSNGAVVFVEPPIRVDPQALVGWADCPSPCHHYDHGYMQGLLGGIRAMTGIGGASGEEHQFQFTGAGQVLLQSTETMQAGLATGAVPHQQGVPGGTPAAYGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8V0</accession>
    <name>A0A0F7N8V0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_22335</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017742.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_22335"/>
    <dbReference type="EnsemblBacteria" id="AKH84481">
        <property type="protein sequence ID" value="AKH84481"/>
        <property type="gene ID" value="AA958_22335"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_22335"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4703"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH84481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="363" mass="39778" checksum="66621C4A3CF12005" modified="2015-07-22" version="1">MELLFALLAIALIAWVAVPLLRRARGGREVLQSNARAVDPAGSYGFVPVDELDVRLPGPDPQLAEVLRELREDQDWQAASRLLALTDDEWEQRWQRVQTLAGAAAFELAQAPGEGGAWLRTWRAEKPKDVGGAEVHAEFLVRQAWMAGAGASEFPVILEEAKKICAEAAMLAPGSPMPYIIELAIARGAHYREADFEELWHTVEQRAGDHMGAHLAALQYACEKWHGSREAAYDFAQRAAASAGPGALLPALPLFAVWEHLPEANLVRGLYEGEVVRQAIEGAQYAVHHAPADHPMLPHVRHLLACFLVRAERYEEALEQMRHVDGYVGALPWSLSEQPAAEYAAYRALAVAGYEGGRGAALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8Z3</accession>
    <name>A0A0F7N8Z3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_18705</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017191.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH83894">
        <property type="protein sequence ID" value="AKH83894"/>
        <property type="gene ID" value="AA958_18705"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_18705"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3922"/>
    <dbReference type="OrthoDB" id="864331at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH83894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="283" mass="30999" checksum="6BA979A764DECF0B" modified="2015-07-22" version="1">MTTSRMEGSCLPSYRTLSTLALSEPEEHVRELTDWVEHASAVSSVPGAQNDWDRAYKWLRLAQGLRAVTFDMSYDDGGMCSAGLDFDAVWTEMMEEWQQHQVRLGYLRAALEGFVRLLHPVTTEPGLAVEAAEQRLHHRGDAWLVHARAVADHLRTHAPGRVLGASTPVVAAVTQAIALHETAVRGRAAIPEPDSDADGKVFPAGHGEICAVKEASTVLLLGIQLLMAAAVQEDRVAVFDDKYLLDGMWIPDASGGSRWVDEEMPYGEYLAVLHLQPGEPPDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9M6</accession>
    <name>A0A0F7N9M6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LuxR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_23870</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017993.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_23870"/>
    <dbReference type="EnsemblBacteria" id="AKH84741">
        <property type="protein sequence ID" value="AKH84741"/>
        <property type="gene ID" value="AA958_23870"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_23870"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5030"/>
    <dbReference type="OrthoDB" id="1687028at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="3"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="148"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH84741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="214" mass="22136" checksum="EFA21FEEDBB25509" modified="2015-07-22" version="1">MIRVLVVDDDAFVRGGLRDLIATDEGLELAGEAAEGAAAVAAARGRRADVALVDIRMPGMDGIAATAALCRLPDPPAVIVLTTFDLDEYVYGALAAGAAGFLLKDTPPDAILQAIHVVAAGAAMLSPTVTRTVISRFHHPEATRSLAAREAAARLTPRERQVLSAVADGMTNAEIGAMLGLRESTVKAHVSRILAELGVTNRVQAALAARDLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9P4</accession>
    <name>A0A0F7N9P4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_26910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018502.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_26910"/>
    <dbReference type="EnsemblBacteria" id="AKH85265">
        <property type="protein sequence ID" value="AKH85265"/>
        <property type="gene ID" value="AA958_26910"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_26910"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5660"/>
    <dbReference type="OrthoDB" id="1770401at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021421">
        <property type="entry name" value="DUF3071"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11268">
        <property type="entry name" value="DUF3071"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="361" mass="38797" checksum="433F522F327ABCC8" modified="2015-07-22" version="1">MPELRVVAVSNDGTRLVLKAADSTEYTLPIDERLRAAVRNDRARLGQIEIEVENHLRPRDIQARIRAGASAEEVAALAGIPVDRVRRFEGPVLAERAFMAERARKTPLRRPGESAGPALGEAVAERLMMRGAEKDSARWDSWRRDDGTWEVLLVYRVAGEPHSAGWTYDPPRRLVQPVDDEARALIGETDASPEPSLPFVPKIARLPRSPERPSDGRGDRDGAGEDRDSLTSLLEAVPSFRGDLVVPDQSAPAAASDGPAAAAGSAGSATKPGPVHGPVPGPPPEEEPEPAAVEEEPPAPAASAGSAYADVLMPRSVSAHRERLTGQTDRQAEADGVRPGRRAAVPSWDEIVFGSRRKKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9V7</accession>
    <name>A0A0F7N9V7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cell shape-determining protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_20945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017534.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_20945"/>
    <dbReference type="EnsemblBacteria" id="AKH84249">
        <property type="protein sequence ID" value="AKH84249"/>
        <property type="gene ID" value="AA958_20945"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_20945"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4413"/>
    <dbReference type="OrthoDB" id="1506822at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002909">
        <property type="entry name" value="IPT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01833">
        <property type="entry name" value="TIG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00429">
        <property type="entry name" value="IPT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IPT/TIG" evidence="1">
        <location>
            <begin position="2"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="IPT/TIG" evidence="1">
        <location>
            <begin position="83"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="IPT/TIG" evidence="1">
        <location>
            <begin position="166"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="IPT/TIG" evidence="1">
        <location>
            <begin position="251"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="330" mass="31603" checksum="4D2C17997E57CCF8" modified="2015-07-22" version="1">MAPVISALNPTQGPAAGGNQVTISGSSFIGATAVRFGTNSAAFGVVSNSQITAFPPPGSGAVTVRVTSPSGTSNGVTYTYVPAPVLTSLAPGQGPTSGGNPVILTGTGFTGASTVQFGAASAVFTVNSSTQITATAPAGSGSVAVTVTTPGGTSNSLTYTYVTAAAPVVIDLGSHFGPTAGGNSVTILGAGLTGATAVHFGAQAAGFTVVGDNQITATAPAGTGTVVVTVTTPGGTSSTGIGNPYYTYVAQPALTSLAPDTGPATGGTGVTINGTALTYTDKVFFGATLATFAAISDTIVLATAPPGAGSVPVTVHSPGGTSNPLTYTYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NA11</accession>
    <name>A0A0F7NA11_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Phytoene dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_24645</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1 4">Carotenoid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the carotenoid/retinoid oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018118.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_24645"/>
    <dbReference type="EnsemblBacteria" id="AKH84866">
        <property type="protein sequence ID" value="AKH84866"/>
        <property type="gene ID" value="AA958_24645"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_24645"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5197"/>
    <dbReference type="OrthoDB" id="418913at2"/>
    <dbReference type="UniPathway" id="UPA00556"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016117">
        <property type="term" value="P:carotenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014105">
        <property type="entry name" value="Carotenoid/retinoid_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008150">
        <property type="entry name" value="Phytoene_DH_bac_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02734">
        <property type="entry name" value="crtI_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00982">
        <property type="entry name" value="PHYTOENE_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0125">Carotenoid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amino_oxidase" evidence="6">
        <location>
            <begin position="18"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="489"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="497"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH84866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="523" mass="55543" checksum="9EE4BD706D767CF9" modified="2015-07-22" version="1">MKRVPGPTGHVVVVGAGLSGLACALHLLGAGRRVTVVERDAGPGGRAGRVLQGGYEMDTGPTVLTMPHLADEAFAAVGDSLHRRVELTALHPAYRACFADGSSLDVHTDGEAMEAEVRRFAGPAQAAGYRDLRQWLERLYRAQMSRFIDANFDSPFQLLHPDLARLAALGGFGRLDGRIGRFLSDERLRRIFSFQALYAGVTPARALAAYAVIAYMDTVAGVWFPKGGVHALPRAMADAAAEAGADLRWKAEVRALEHSVGRVRAVRLASGDRIPCDAVVLTCELPAAYGLLGRTPRRPARLCHSPSAVILHAGTDRTWPHLAHHTLSFGAAWEGTFEELTRTGKLMSDPSLLITRPTAHDPALAPPGRHLHYVLAPCPNTAVGPAALAWQELGPRYRDRLVGELERRGLDGFADSVREELLVTPLDWARQGHAAGSPFSVSHTFAQTGPFRPRNLVRGLDNVVLAGCGTTPGVGIPTVLISGKLAAARVTGGGGPRPAPPRRPPAVPGTAPVPVPAGADDPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NA77</accession>
    <name>A0A0F7NA77_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_16935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016921.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH83617">
        <property type="protein sequence ID" value="AKH83617"/>
        <property type="gene ID" value="AA958_16935"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_16935"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3563"/>
    <dbReference type="OrthoDB" id="1196738at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="30"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="281" mass="29244" checksum="61E184A86D2009D8" modified="2015-07-22" version="1">MREIDVELEGGRRLHVYDTGGEGRDDRLAVFWHHGTPNVGAPPGPLLPDAERLGLRWVSYDRPGYGGSSPWPGRDMASAAALASRVADELGIGRFAAVGHSSGGPHALACGALAPDRVAAVVSVAGPAPFGAAGLDWFAGMASSVAESLRAAVAGRAAKEEHEAEAAYEPEMFTAADHAALAGAWSWFDDVVGPAVAGSPDGLVDDDLANVGPWGFDPAAVTAPVLLLHGGRDRVIPRTHGEWLARHCPAAELWIRPEDGHISVLGSGATALEWLREQSAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAA6</accession>
    <name>A0A0F7NAA6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH lacI-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_28225</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018714.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH85480">
        <property type="protein sequence ID" value="AKH85480"/>
        <property type="gene ID" value="AA958_28225"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_28225"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5949"/>
    <dbReference type="OrthoDB" id="664909at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="6"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH85480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="332" mass="34536" checksum="C32C7695ABF3D592" modified="2015-07-22" version="1">MPPEQATLSDIAARAGVSVSTVSKVLHARTDVAPATRERIARLLADHGYRPSRGAGVVDLVIGSLNSPWADALVTGAVEAGAEADCRIVIDSVPDSADVLRHTLERIMARGSDGVLLVHQVPAPETRARLAAKRIPLVAIDPPAEPGAGVRSVGCTNWQGGLAATRHLIELGHRRIATLTGPLTIWSARARFDGYRAALLEAGLPVAEELIRNADFFAPDGRAGALALLDLPEPPTAVVAANDGQAFGVLQALAERGLRAPADMSVTGFDDTPVAAWAAPPLTTVAQPLEAMAATAFRMLRLHGEGGAAQPEQVELATTLTVRASTGPPPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAL7</accession>
    <name>A0A0F7NAL7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidoglycan-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_26055</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018352.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_26055"/>
    <dbReference type="EnsemblBacteria" id="AKH85111">
        <property type="protein sequence ID" value="AKH85111"/>
        <property type="gene ID" value="AA958_26055"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_26055"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5486"/>
    <dbReference type="OrthoDB" id="1968187at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.101.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036366">
        <property type="entry name" value="PGBDSf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="SSF47090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="PG_binding_1" evidence="3">
        <location>
            <begin position="167"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH85111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="400" mass="40566" checksum="258F1B76566786D2" modified="2015-07-22" version="1">MTAQPAASRREPGPGGPAAADEPAADPTATDLPGADPSPPRRGRHRRRRRRMAAGAVFLAATGGAAAAGLGLGGTGGPAGAADGELPPATAEVTRDTLVDTRSADAELGHGPATGAAARTDGTLTELPRAGARVTRGEALYELDDEPVTLLYGDLPAYRTLAPGAEGTDVAQLERNLSALGYTGFTVDDAYSGATAAAVRDWQDDLGAGATGRVEPGQVVFAPGPVVVASVDAQRGDLVVPGADVLTYTGTDVAVTAELDVADRRLARRGAKVGVELPDGRTVRGTVAEVSVRTRPADGEQEARTVVEVVVRLKGAEARKAASAYDEAGVHVDFTAGRRENVLTVPVAALLALAEGGFGVEVVTDGTTRYVPVETGLFAGGRVEVSGEGLTAGTKVGMPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NB18</accession>
    <name>A0A0F7NB18_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MerR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_18505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017164.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH83867">
        <property type="protein sequence ID" value="AKH83867"/>
        <property type="gene ID" value="AA958_18505"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_18505"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3885"/>
    <dbReference type="OrthoDB" id="1515497at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="38"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="247" mass="26733" checksum="A5AE39B1ED2A7E00" modified="2015-07-22" version="1">MAVYDTLGTTYATTRQPDPRIAARIHAALGEAMDVVNVGAGTGSYEPPHTVLAVEPSPVMLAQRPPGSALAVRAVAERLPLRDDAADAVLAVLTVHHWTDLAAGIAELCRVARRRVVILTWDQQVFRDQFWLVREYLPEAAALDDTRATPIDHLATLLGGARQETVAVPHDCTDGFAAAYWRRPHAYLDPRVRAGISLLAQSGEATLAPGLAALAADLTTGRWQRRHADLLTRDTIDVGYRLLVADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBI0</accession>
    <name>A0A0F7NBI0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">1-deoxy-D-xylulose-5-phosphate synthase</fullName>
            <ecNumber evidence="10">2.2.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">1-deoxyxylulose-5-phosphate synthase</fullName>
            <shortName evidence="10">DXP synthase</shortName>
            <shortName evidence="10">DXPS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">dxs</name>
        <name evidence="12" type="ORF">AA958_24380</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>D-glyceraldehyde 3-phosphate + H(+) + pyruvate = 1-deoxy-D-xylulose 5-phosphate + CO2</text>
            <dbReference type="Rhea" id="RHEA:12605"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="10">Binds 1 thiamine pyrophosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Metabolic intermediate biosynthesis; 1-deoxy-D-xylulose 5-phosphate biosynthesis; 1-deoxy-D-xylulose 5-phosphate from D-glyceraldehyde 3-phosphate and pyruvate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 10">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the transketolase family. DXPS subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.7" evidence="10"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018080.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_24380"/>
    <dbReference type="EnsemblBacteria" id="AKH84828">
        <property type="protein sequence ID" value="AKH84828"/>
        <property type="gene ID" value="AA958_24380"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_24380"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5138"/>
    <dbReference type="OrthoDB" id="566385at2"/>
    <dbReference type="UniPathway" id="UPA00064">
        <property type="reaction ID" value="UER00091"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008661">
        <property type="term" value="F:1-deoxy-D-xylulose-5-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052865">
        <property type="term" value="P:1-deoxy-D-xylulose 5-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02007">
        <property type="entry name" value="TPP_DXS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00315">
        <property type="entry name" value="DXP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005477">
        <property type="entry name" value="Dxylulose-5-P_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020826">
        <property type="entry name" value="Transketolase_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43322">
        <property type="entry name" value="PTHR43322"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13292">
        <property type="entry name" value="DXP_synthase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00204">
        <property type="entry name" value="dxs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00801">
        <property type="entry name" value="TRANSKETOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00802">
        <property type="entry name" value="TRANSKETOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TRANSKETOLASE_1" evidence="11">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Thiamine pyrophosphate binding" evidence="10">
        <location>
            <begin position="114"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Thiamine pyrophosphate binding" evidence="10">
        <location>
            <begin position="147"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="369"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS00801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AKH84828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="635" mass="66895" checksum="321C1A09DB9DDFED" modified="2015-07-22" version="1">MTLLDSLRGPKDLKDLGPNELTGLAAEIRDRLISTVSANSGHLGPNLGVVELTIAMHRVFDSPRDPLIFDTGHQSYVHKLLTGRQEEFATLRQPGGMSGYPCQAESPHDHVENSHASTSLSYADGLGKAFKLRGEDDRTVAAVIGDGALTGGMAWEALNNIAAAKSNRVVIIVNDNGRSYSPTHGAIATHLAQVRTSQKYENVLASIKSTLPRTPLVGAPLYETLHGIKKGLKDVLQPQVMFEDLGLKYVGPIDGHDQAGLELALAHAKDFGGPVIVHVLTRKGHGYAPAENNDEDHLHQVGANTDPLTGAPVKKAARTWSHVFADEILKIGGKREDVVAITAAMLHPTGLAPFAKAHPDRVFDVGIAEQHAVTMAAGLAMGGLHPVVALYSTFLNRAFDQMLMDVALHKLPVTFVLDRAGVTGPDGASHNGMWDGSISQMIPGMRVAAPRDAKRLSELLTEALDDATGPTLLRWPKAPAGEEVPGLGKLGGMDVVARPEEGTATDVLLVGAGVMAGVCADAAARLADQGIGALAVDPRWVKPVDPALAAAARDVRLVVTVEDNGISGGFGDAVCRDLRDAGVATPVTSFGLPQEFLDHNTRGGILEQAGLTGQHIARSVTEAVSGRRGEVVGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBK0</accession>
    <name>A0A0F7NBK0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_30565</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019068.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH85840">
        <property type="protein sequence ID" value="AKH85840"/>
        <property type="gene ID" value="AA958_30565"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_30565"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6459"/>
    <dbReference type="OrthoDB" id="1539320at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="14"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH85840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="153" mass="16629" checksum="7B849F11524F88EB" modified="2015-07-22" version="1">MPTDSGVFAEGSRALRYTLAGIVLLALVYVAGVFAWGGAAWSTAPFRGAAEARERTVGSGEFRISTYEEFFDLCAAVQTKEDEIGALRDELDTKPSEYRTDQITTSLTALRAARSELVNDYNAKSRQEHRKAFKDAGLPAELSTDAKETPCAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBN8</accession>
    <name>A0A0F7NBN8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9 10">Endo-1,4-beta-xylanase</fullName>
            <ecNumber evidence="3 9 10">3.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">AA958_30925</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9 10">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-xylosidic linkages in xylans.</text>
            <dbReference type="EC" id="3.2.1.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9 10">Glycan degradation; xylan degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the glycosyl hydrolase 11 (cellulase G) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.8" evidence="3 9 10"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019123.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_30925"/>
    <dbReference type="EnsemblBacteria" id="AKH85895">
        <property type="protein sequence ID" value="AKH85895"/>
        <property type="gene ID" value="AA958_30925"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_30925"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6536"/>
    <dbReference type="OrthoDB" id="1121261at2"/>
    <dbReference type="UniPathway" id="UPA00114"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031176">
        <property type="term" value="F:endo-1,4-beta-xylanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013319">
        <property type="entry name" value="GH11/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018208">
        <property type="entry name" value="GH11_AS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033123">
        <property type="entry name" value="GH11_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001137">
        <property type="entry name" value="Glyco_hydro_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00457">
        <property type="entry name" value="Glyco_hydro_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00911">
        <property type="entry name" value="GLHYDRLASE11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00776">
        <property type="entry name" value="GH11_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51761">
        <property type="entry name" value="GH11_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7 9 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 9 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9 10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9 10" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519342" description="Endo-1,4-beta-xylanase" evidence="11">
        <location>
            <begin position="40"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="GH11" evidence="12">
        <location>
            <begin position="41"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9">
        <location>
            <position position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AKH85895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="228" mass="24640" checksum="34A355672FDF3D04" modified="2015-07-22" version="1">MNTNGTPHGVSRRQFVGRAGAVALGASAATLLPAGVAHAQTITTNQTGNHNGYYYSFWTDAQGTVSMTLGNGGNYSTSWRNTGNFVCGKGWSNGSRRNVNYSGSFSPSGNGYLCLYGWTSNPLVEYYIVDSYGTYRPTGENHGSVSSDGVTYDIYRTMRYNAPSVEGTKTFPQFWSVNRSRRVGGTINTGTHFDAWSRAGMQLGNFSYYMIMATEGFQSSGSSNINVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBT1</accession>
    <name>A0A0F7NBT1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alkane 1-monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_24905</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018159.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_24905"/>
    <dbReference type="EnsemblBacteria" id="AKH84908">
        <property type="protein sequence ID" value="AKH84908"/>
        <property type="gene ID" value="AA958_24905"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_24905"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5250"/>
    <dbReference type="OrthoDB" id="1434838at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="343" mass="36146" checksum="7ED9DEC1DB55D5FE" modified="2015-07-22" version="1">MHIGSFVLGAQFPGQGQGDALHRAVRTGVAAEEAGLDSVWLAEHHFIPYGTCPSAVTLAALLLGRTSRISVGTAVSVLPTQHPVALGEQAALLHHAAQGRFVLGVGRGGPWVDLEVFGTGLAAYESDFPESLDLLLRWLREPRVGAGGDRYAFREVAVVPRPAEALHGAGDVPVLVACTSPGTVRLAAGRGLPMLLGMHCGDEEKAEMVRLWRRTAREAGMSPEAIDAAGHVSAGVAQVDDTPEDAAKLLRTALPGAFRSGVGAMETVDGRRRPMRDPEAYTELLCALHPVGPPRLCADRLAATAERTGITRFALLVEGSGELGATERNVRRIGAEVLPLLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBU6</accession>
    <name>A0A0F7NBU6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MbtH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_29280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018885.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_29280"/>
    <dbReference type="EnsemblBacteria" id="AKH85656">
        <property type="protein sequence ID" value="AKH85656"/>
        <property type="gene ID" value="AA958_29280"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_29280"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6174"/>
    <dbReference type="OrthoDB" id="2067093at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005153">
        <property type="entry name" value="MbtH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038020">
        <property type="entry name" value="MbtH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037407">
        <property type="entry name" value="MLP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38444">
        <property type="entry name" value="PTHR38444"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03621">
        <property type="entry name" value="MbtH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00923">
        <property type="entry name" value="MbtH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160582">
        <property type="entry name" value="SSF160582"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MbtH" evidence="1">
        <location>
            <begin position="6"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="73" mass="8126" checksum="C02AD40337FCD1F6" modified="2015-07-22" version="1">MTDTVNAFDVPDARYHVLVNPEGQYSLWPALTDVPAGWEPVHGPAGRAQCVEYVESNWTDMRPATLRVALDEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCK4</accession>
    <name>A0A0F7NCK4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 9">tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase</fullName>
            <ecNumber evidence="8 9">2.8.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">(Dimethylallyl)adenosine tRNA methylthiotransferase MiaB</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">tRNA-i(6)A37 methylthiotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">miaB</name>
        <name evidence="13" type="ORF">AA958_26605</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>[sulfur carrier]-SH + AH2 + N(6)-dimethylallyladenosine(37) in tRNA + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:37067"/>
            <dbReference type="Rhea" id="RHEA-COMP:10375"/>
            <dbReference type="Rhea" id="RHEA-COMP:10376"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="ChEBI" id="CHEBI:74415"/>
            <dbReference type="ChEBI" id="CHEBI:74417"/>
            <dbReference type="EC" id="2.8.4.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="9">Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the methylthiotransferase family. MiaB subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.4.3" evidence="8 9"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="WP_047018446.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
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    <dbReference type="STRING" id="444103.AA958_26605"/>
    <dbReference type="EnsemblBacteria" id="AKH85209">
        <property type="protein sequence ID" value="AKH85209"/>
        <property type="gene ID" value="AA958_26605"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_26605"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5598"/>
    <dbReference type="OrthoDB" id="397139at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
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    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="F:metal ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:methylthiotransferase activity"/>
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        <property type="term" value="P:tRNA modification"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="tRNA_metthiotr_MiaB"/>
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        <property type="entry name" value="Elp3/MiaB/NifB"/>
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        <property type="entry name" value="Methylthiotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020612">
        <property type="entry name" value="Methylthiotransferase_CS"/>
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        <property type="entry name" value="Methylthiotransferase_N_sf"/>
    </dbReference>
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        <property type="entry name" value="MiaB_methiolase"/>
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        <property type="entry name" value="rSAM"/>
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        <property type="entry name" value="rSAM_horseshoe"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00919">
        <property type="entry name" value="UPF0004"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="(dimethylallyl)adenosine_tRNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00089">
        <property type="entry name" value="TIGR00089"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MTTASE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01278">
        <property type="entry name" value="MTTASE_RADICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="7 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 9 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="MTTase N-terminal" evidence="11">
        <location>
            <begin position="9"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="12">
        <location>
            <begin position="149"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="TRAM" evidence="10">
        <location>
            <begin position="382"/>
            <end position="450"/>
        </location>
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    <feature type="binding site" evidence="9">
        <location>
            <position position="18"/>
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        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
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        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
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    <feature type="binding site" evidence="9">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
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    <feature type="binding site" evidence="9">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
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        <location>
            <position position="170"/>
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        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
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    </feature>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
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    </evidence>
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        </source>
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        </source>
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            <dbReference type="EMBL" id="AKH85209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="498" mass="54237" checksum="93BF9A0ED8765ADB" modified="2015-07-22" version="1">MPEEVAQPRTYEVRTFGCQMNVHDSERMSGLLEEAGYVRAEPDAGTADVVVFNTCAVRENADNRLYGNLGQLAPKKAAKPGMQIAVGGCLAQKDRDTIVSRAPYVDVVFGTHNVGKLPVLLERARVAREAQVEIAESLEAFPSTLPTRRESPYAAWVSVSVGCNNTCTFCIVPALRGKEKDRRSGDILAEVEALVSEGVSEITLLGQNVNAYGSDIGDRQAFGKLLRACGRIEGLERVRFTSPHPRDFTDDVIEAMAETPNVMPQLHMPLQSGSDTVLRAMRRSYRQERYLGIIEKVRAAIPDAAITTDIIVGFPGETEADFEQTLHVVREARFAQAFTFQYSKRPGTPAAEMAGQVPKAVVQERYERLVALQEDISWGENRKQVGRVLEVMVAEGEGRKDGATRRLSGRAPDNRLVHFARPEDPVRPGDMATVEITYAAPHHLLAEAPPRAVRRTRSGDAWAARQAAPDAGGTGVLLGLPKVGVPDPLPAAQGCAAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCW1</accession>
    <name>A0A0F7NCW1_9ACTN</name>
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        <submittedName>
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        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">AA958_27220</name>
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        <name type="scientific">Streptomyces sp. CNQ-509</name>
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            <taxon>Bacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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    <dbReference type="EnsemblBacteria" id="AKH85309">
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    <dbReference type="Proteomes" id="UP000034283">
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    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="67" mass="6692" checksum="DEC42F00A1E69848" modified="2015-07-22" version="1">MTDQADKAELLRSLHIPGVPLMLPNAWDVGSARAVAAAGFPVVATASNASTPPPPRSATAPGSRAGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDC8</accession>
    <name>A0A0F7NDC8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Iron transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_33070</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IucA/IucC family.</text>
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        <property type="protein sequence ID" value="AKH86251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_33070"/>
    <dbReference type="EnsemblBacteria" id="AKH86251">
        <property type="protein sequence ID" value="AKH86251"/>
        <property type="gene ID" value="AA958_33070"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_33070"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6986"/>
    <dbReference type="OrthoDB" id="210513at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016881">
        <property type="term" value="F:acid-amino acid ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019290">
        <property type="term" value="P:siderophore biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007310">
        <property type="entry name" value="Aerobactin_biosyn_IucA/IucC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022770">
        <property type="entry name" value="FhuF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037455">
        <property type="entry name" value="LucA/IucC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34384">
        <property type="entry name" value="PTHR34384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06276">
        <property type="entry name" value="FhuF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04183">
        <property type="entry name" value="IucA_IucC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IucA_IucC" evidence="3">
        <location>
            <begin position="151"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="FhuF" evidence="4">
        <location>
            <begin position="399"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="562"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH86251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="581" mass="61759" checksum="78F83FCB96D8123E" modified="2015-07-22" version="1">MPRTASPATSPASASPAGLPTADEAVAHTLLNCLLREVCGPGRQATVGGGRLLLRLPRRGVLLRVAVRRTSLLGAHRFRGPAAEWRDGDWAEAGWRRLAELVQDELSARTGVRNDEFLEQVAASHRGTADALAAVRERRAPAAGAGPLAAYLDSEQSLPLGHRFHPTPKARDGGTAAWSAYAPEAGAAFPLRHLAVRAHLTAEETARPGAAAPLDRLRPVPDGYRLLPVHPWQHELLAGHPALRAALDRGDVLDLGTGGPPCTPTASVRTLHTGDGFLKFSLNVRITNCVRKNSRYELSGAVALTRLLHPVLDALAARHPAAALLREPAYRGLALPGPGGAPDPALLEGFGVIVRDGLSGVLRPGVTPLLAAAVADEYPTGPAHLSRLPPTAAPQTALDWWSVYLELLVPPVLAAYFDHGVVLEPHLQNVLLCVDGEGMPAQVVFRDLEGTKLLPGRHSGALAALPAEVAGPITYDASRGWHRVVYCLLVNHVADMLAALADLHPRAEAALWARVRAVLLDCARDLGDPPRLRALLGGAPLPAKANLLTRWGRRADREAGYVHLPNPLSAPSPDSPRRSHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDD5</accession>
    <name>A0A0F7NDD5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_23850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017989.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_23850"/>
    <dbReference type="EnsemblBacteria" id="AKH84737">
        <property type="protein sequence ID" value="AKH84737"/>
        <property type="gene ID" value="AA958_23850"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_23850"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5026"/>
    <dbReference type="OrthoDB" id="1850835at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH84737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="69" mass="7604" checksum="A761A8E2B3B24A1F" modified="2015-07-22" version="1">MSEATELAGRAGGTDPREGLRAVAALRRLLEQLEAVQVRSARNQGWSWQEVAAELGVSRQAVHKKHGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDI0</accession>
    <name>A0A0F7NDI0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADPH:quinone reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_24065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018029.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH84777">
        <property type="protein sequence ID" value="AKH84777"/>
        <property type="gene ID" value="AA958_24065"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_24065"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5072"/>
    <dbReference type="OrthoDB" id="1752728at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="10"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="295" mass="28824" checksum="C941C2F676BD6D05" modified="2015-07-22" version="1">MRAAVVTEFGGPEAVTIADVEVVEPGAGQVRIKVAAAAVNPVDAGTRAGVFGAAPGGAYTGLGWDVAGTVDVAGAGFAAGEAVVALVHGVAKPLGSHAEYVVVDGAAAAPAPATADAVHAATLPLNALAADQALGLLDLTPGTSLLVTGAAGALGGYAIQLAAARGVAVTGLARETDEELVRGLGAAFTTAPAAAGYDAVLDAAVLGGERALPWTRDGGAFAAVIPNTAPPPVRGIRTAALDVRADGPRLAELARLVDDGVLTLRVAGTYDLADAPKAHARLAEGGIRGRLVLVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDK6</accession>
    <name>A0A0F7NDK6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA small subunit methyltransferase H</fullName>
            <ecNumber evidence="6">2.1.1.199</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">16S rRNA m(4)C1402 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">rRNA (cytosine-N(4)-)-methyltransferase RsmH</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rsmH</name>
        <name evidence="7" type="ORF">AA958_06570</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>cytidine(1402) in 16S rRNA + S-adenosyl-L-methionine = H(+) + N(4)-methylcytidine(1402) in 16S rRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42928"/>
            <dbReference type="Rhea" id="RHEA-COMP:10286"/>
            <dbReference type="Rhea" id="RHEA-COMP:10287"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74506"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.199"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the methyltransferase superfamily. RsmH family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.199" evidence="6"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019827.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_06570"/>
    <dbReference type="EnsemblBacteria" id="AKH86580">
        <property type="protein sequence ID" value="AKH86580"/>
        <property type="gene ID" value="AA958_06570"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_06570"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1371"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071424">
        <property type="term" value="F:rRNA (cytosine-N4-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01007">
        <property type="entry name" value="16SrRNA_methyltr_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002903">
        <property type="entry name" value="RsmH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023397">
        <property type="entry name" value="SAM-dep_MeTrfase_MraW_recog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11265">
        <property type="entry name" value="PTHR11265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01795">
        <property type="entry name" value="Methyltransf_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004486">
        <property type="entry name" value="MraW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81799">
        <property type="entry name" value="SSF81799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00006">
        <property type="entry name" value="TIGR00006"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6 7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="6">
        <location>
            <begin position="28"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH86580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="308" mass="33128" checksum="BADA92BA82ED94D5" modified="2015-07-22" version="1">MLRRTTELLAPALSAPGAVAVDCTLGLGGHSEALLAAHPGLRLIALDRDPAALELAGRRLAPYTGRVTLVHAVYDELPDVLDKLAVGHVQGILFDLGVSSMQLDEAGRGFAYAQDAPLDMRMDQTRGVSAAEVLNTYPPGELVRILRAYGEEKQARRIVEAVVREREKEPFARSARLVEVIREALPQAAKRTGGNPAKRTFQALRIEVNGELAVLERAVPAAVAALAVGGRIAVLAYQSLEDRLVKRVLAAGAASTAPPGLPVVPEHHQPRLRLLTRGAELPAEEEIAENRRAAPARLRAAERIREDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-10-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDM4</accession>
    <name>A0A0F7NDM4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_28240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018717.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH85483">
        <property type="protein sequence ID" value="AKH85483"/>
        <property type="gene ID" value="AA958_28240"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_28240"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5952"/>
    <dbReference type="OrthoDB" id="1439189at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH85483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="312" mass="33708" checksum="57880AADC407EE97" modified="2015-07-22" version="1">MDLDAVRTFVAAADTGQFQEAAAELMLTQQAVSKRIAGLEKGLGVRLFTRTARGAKLTIDGQAFLPHARTLLQAAERAAASVRPGSRALRVDVVGRRVATAGLLRDFHRAHPEVELDVVTVYGGGPAVEAVRDGTIDATFRTLPPPGRKLPDDIAVGYVMYEPVQLVTGPAHEFAGARSVRPAQLAGHRIWMPGNAPGTEWAAYYEDMAAEFGFVIDAVGPDFGVESLLDTVAESTTVGTFLSERTPLVWPVDYDLCRIPLLDPTPVYPHLLHWHTDNAHPGLALLRDYAAARAPRHTPTDPAGTWAPAWSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDY0</accession>
    <name>A0A0F7NDY0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cation diffusion facilitator family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_11340</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019961.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_11340"/>
    <dbReference type="EnsemblBacteria" id="AKH86690">
        <property type="protein sequence ID" value="AKH86690"/>
        <property type="gene ID" value="AA958_11340"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_11340"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2386"/>
    <dbReference type="OrthoDB" id="381612at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006829">
        <property type="term" value="P:zinc ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040177">
        <property type="entry name" value="SLC30A9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13414">
        <property type="entry name" value="PTHR13414"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="SSF160240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="SSF161111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH86690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="307" mass="32480" checksum="96113A99FC88181A" modified="2015-07-22" version="1">MAAGGGTKAILAALGANLSIAVAKFVAWAFSGSSSMLAEAVHSLADSGNQALLLLGGKRAKRAATKEHPFGYGRERYVYAFLVSIVLFTVGGLFAIYEGYHKIEDPHEIDHWYWPVGVLVFAIIAETISFRTAIKESNEVRGSQGWWQFIRRAKAPELPVVLLEDLGALVGLILALLGVGVALATGDGVWDGIGTVSIGVLLLIIAVILAVETKSLLLGEGASEADVEAISTALVDGDAVTQVIHLKTLYLGPDELLVAAKIAVQHDDTAGEVARAIDAAESRVREAVPVARMIYLEPDIARAQTDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDZ3</accession>
    <name>A0A0F7NDZ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_00195</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019666.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_00195"/>
    <dbReference type="EnsemblBacteria" id="AKH86456">
        <property type="protein sequence ID" value="AKH86456"/>
        <property type="gene ID" value="AA958_00195"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_00195"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.44"/>
    <dbReference type="OrthoDB" id="7548at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002543">
        <property type="entry name" value="FtsK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032030">
        <property type="entry name" value="YscD_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01580">
        <property type="entry name" value="FtsK_SpoIIIE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16697">
        <property type="entry name" value="Yop-YscD_cpl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SSF49879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50901">
        <property type="entry name" value="FTSK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="FHA" evidence="4">
        <location>
            <begin position="100"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="FtsK" evidence="5">
        <location>
            <begin position="625"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="domain" description="FtsK" evidence="5">
        <location>
            <begin position="957"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="644"/>
            <end position="651"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="973"/>
            <end position="980"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH86456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="1401" mass="147775" checksum="310B7E392087DDD1" modified="2015-07-22" version="1">MRVVHSHGRSERELELRIGRPDATLADLAAALGVPVGGLSLDGRVVPPETGMHESGLADGSRLVTGKDHVELRPGQTAVVLRLVGGLEAGRSVSLPADRTVIGRGTGVDVRVAATGVSREHAALEVSPDGRVAVTDLISANGTDLNGRRITETVALAPEDLVSLGGETLLRVLPPDRLGLTQRVNPVREAGLSGTLPFNRPPRGGAPIVRPPLEVPAALAQSGKTPFSVSSMLGPLLMAGAIVALTHDVRYAAIAALSPLMFLANFAEDRLRGRFGLRRGRRAHAARLAAFGKAVEAAHLSEVRACRSAYPDAAEVVYRATAPALTLWERRPGAPDFLRAVAGWGDLPWAPPLRSEGSGTAPEAEAILARYGTLPQVPVVVGLAGGEVVGLEGERRACLAVARSLLCQAVVGSGPADVTVAVFADPERLADWDWTKWLPHGADLRSSSTRLVAAGPEQVDALARNLRSTAAAAASGGQRQDGPVLLVVVDGAALLEGRPCPLRDLLAGASLGCGGIVLTTRLPALCTTVVTASAEGTGRVRDVASDVAVDGVLLQGMPLAEARRTARALARYEDPELPMEGATLPDRITLLPLLDLQDTTGEAIGDRWKSRVPALRVQAVLGVSERDLFAVDLDDDGPHALIAGTTGSGKSELLRTLIAAMAVDADPEHLTFVLVDYKGGGALDECAEFPHTVGLVTDLDEQLGQRALRCLEAEVHHRERLLRPLGLSHIRDYQRLRDTGRHDLEPMPRLVVVIDEFATLVKALPDFVDALVSVAQRGRSLGVHLVMATQRPAGSVSDAIKNNVKMRIALRLESSTDSQDVIDDSASAAIGSRQWGRAYYRLSAREVLPVQTALSTGVTPRAAVTAPVTTVPFVLSGAAPEASGDAEGPTDLQRLVTAAREAFDQQGFAPPRRPWPDVLPAQILAADLAAVAERGLQTQTTSLPAYALADDPDRQCQYPVGWDPAAGNLLVYGASGSGTTTALTALALSQARHHPPDRLHLFALDFGAGGLAPLDALPHTGAHIGAAERERQVRLIRLLRRELDSRKAAGPVPAPDWLVLVDNLGALLSDFDKDVTSLNLVDELARVYADGPAVGIRFAVTADRSGAVPTAWSALTLQKLLMRLADPGEYSYFDVPRAAVPTYVPGRALVAASHQVVQIALPGDDLADTVTQVAELWPDATRSAPGIGLLPPEVPCADLDATASTTSDPWWIPVGLDADSLSSAGLRLHERDHALIAGPQRSGRSTALCTLARQAANAPTAAVLAFAPLRSPLRDLPCLTALVTDYEEVDAMLTAHPGPSLLLVDDADTIDDEQGVLQRWLATVSCGHLVAAGRADGFRRLYGHWTQPARDSRCGVLLAPDHDLDGDLLGTTLPRHDRQTPLPGRGYLVTDGIAGGIQVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NE64</accession>
    <name>A0A0F7NE64_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AA958_25435</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0126 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_25435"/>
    <dbReference type="EnsemblBacteria" id="AKH85002">
        <property type="protein sequence ID" value="AKH85002"/>
        <property type="gene ID" value="AA958_25435"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_25435"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5361"/>
    <dbReference type="OrthoDB" id="1665397at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005115">
        <property type="entry name" value="Gly_transporter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03458">
        <property type="entry name" value="Gly_transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="71"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="160"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="Gly_transporter" evidence="8">
        <location>
            <begin position="14"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Gly_transporter" evidence="8">
        <location>
            <begin position="100"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH85002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="220" mass="22978" checksum="B810B659080F24CB" modified="2015-07-22" version="1">MVSDDLFTPSLQHWLDLAGIFVFGISGALLAVRKNFDVFGIAVLALATGLGGGLLRDLVIGAVPPAAFTEPGYLFTPLVAALLVVFLHPEVERITSAVMVFDAAGLGLFCVTGTLKAYEYGLGLTSAAVLGLTSAAGGGVVRDLLAGEVPSLLRWDREMYAVPALVGAVATALLIRFGQVGPATATAAAAVAFVLRLLALRFRWRAPRAWQRRSRAAGEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NEH8</accession>
    <name>A0A0F7NEH8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Trehalose 6-phosphate phosphorylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_30145</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 65 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019001.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_30145"/>
    <dbReference type="EnsemblBacteria" id="AKH85773">
        <property type="protein sequence ID" value="AKH85773"/>
        <property type="gene ID" value="AA958_30145"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_30145"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6366"/>
    <dbReference type="OrthoDB" id="179460at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005194">
        <property type="entry name" value="Glyco_hydro_65_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005195">
        <property type="entry name" value="Glyco_hydro_65_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005196">
        <property type="entry name" value="Glyco_hydro_65_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037018">
        <property type="entry name" value="Glyco_hydro_65_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017045">
        <property type="entry name" value="Malt_Pase/Glycosyl_Hdrlase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03633">
        <property type="entry name" value="Glyco_hydro_65C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03632">
        <property type="entry name" value="Glyco_hydro_65m"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03636">
        <property type="entry name" value="Glyco_hydro_65N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036289">
        <property type="entry name" value="Glycosyl_hydrolase_malt_phosph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_65N" evidence="6">
        <location>
            <begin position="8"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_65m" evidence="4">
        <location>
            <begin position="319"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_65C" evidence="5">
        <location>
            <begin position="739"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="356"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="615"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR036289-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR036289-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH85773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="801" mass="88946" checksum="D366F687336D6187" modified="2015-07-22" version="1">MSDDWTWTYEGYDPSQERLREALCTLGNGNFATRGAAPESGADETHYPGTYAAGVYDRLTSTVSGRQVENEDMVNLPNWLPLRFRARPPAAAPGRWLATADADPVAYRRRLRLRTGVLERSAVFTDAEGRRIELAETRLVHMGVPHLAALRTTLTPLGWSGELEVEAALDGSVTNSGVARYRAYAGRHLTRVETGADDPDTVWLCCRTRASGVRVALAARTRVAAGDVTGSRPVCHGDSGVARLLSVRAVTGEPVTVEKTVALSTSRDPAHVDPLRAAREHVSRSPDFTALLASHTAAWDHLWQRTGLCVPGKAGGILRLHLFHLLQTLSPHTARLDAGVPARGLHGEAYRGHVFWDELFVLPYLNLHLPEVSRALLDYRHRRLPAARRAAAAAGYRGAMYPWQSGSDGREETQEMHLNPRSGHWLPDHSRLQHHVGLAVAYNVWQYGQATGDTAYLYGRGAETVLEVARFFADLAAWDPAYGRHRIRGVLGPDEYHDAYPDARRPGLDDNAYTNVMAAWVLARARELLAGLPGARRRELAGRMGLGEEETTRWEEVSRTLHVPFHRDVISQFEGYGELADFDWDGYRSRYGDIRRLDRILEAEGDSVNRYQASKQADVLMLGYLFSPAELGDVFGRLGHRMDDELWRRTVDYYLARTSHGSTLSSLVHGWVLARARRSSAWTYCQEALASDVADIQGGTTGEGIHLGAMAGTLDMVQRGLTGLAVREDALWLDPVPMPQMSEYVLRLRYRGHRGIELRLRAGRLHVDVPQSAEPPLTLVLPDRTVTVEPGESRRLRLPDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NEJ9</accession>
    <name>A0A0F7NEJ9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">acidPPc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_26195</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018378.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_26195"/>
    <dbReference type="EnsemblBacteria" id="AKH85137">
        <property type="protein sequence ID" value="AKH85137"/>
        <property type="gene ID" value="AA958_26195"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_26195"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5513"/>
    <dbReference type="OrthoDB" id="1928533at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxi_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="SSF48317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="204"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="239"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="acidPPc" evidence="3">
        <location>
            <begin position="168"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH85137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="306" mass="31956" checksum="96BC8E700530B52F" modified="2015-07-22" version="1">MRQAVRVRRAPRRPAARGAERAQEPAQKQARAQGLEPAQAPPLRRWAVAAWAVLGCAVLYGLLAWQVAVDGPVRELDERTGPALSRHAPPGAELLADLGGVGVALPVLAAAMLYAVWRTPVRAGAAPGGAGCTATAPARHGPLRPLDRLHPLRLLHPLHRRVPAAVQVPLLAGAAAFAVLPAVVLPLKSAQARPGPKGPLADDYAGFFPSGHSTTAAVAYGAVVLLLLPLLRSRTARRLLAAAAGAVVLGVGAGLVWREYHWPLDVVAGWCVAGVLLAGCRYGAARLTAYAAARVVPRPPDHPRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NEK0</accession>
    <name>A0A0F7NEK0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">UTP--glucose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="3 4">2.7.7.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">UDP-glucose pyrophosphorylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_12350</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>alpha-D-glucose 1-phosphate + H(+) + UTP = diphosphate + UDP-alpha-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:19889"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.7.7.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the UDPGP type 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.9" evidence="3 4"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019986.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_12350"/>
    <dbReference type="EnsemblBacteria" id="AKH86711">
        <property type="protein sequence ID" value="AKH86711"/>
        <property type="gene ID" value="AA958_12350"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_12350"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2595"/>
    <dbReference type="OrthoDB" id="1402673at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003983">
        <property type="term" value="F:UTP:glucose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006011">
        <property type="term" value="P:UDP-glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02541">
        <property type="entry name" value="UGPase_prokaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005771">
        <property type="entry name" value="GalU_uridylyltTrfase_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43197">
        <property type="entry name" value="PTHR43197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01099">
        <property type="entry name" value="galU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="5">
        <location>
            <begin position="10"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH86711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="302" mass="32967" checksum="2353EFF92869D1EC" modified="2015-07-22" version="1">MDSSRTRITKAVIPAAGLGTRFLPATKATPKEMLPVVDKPAIQYVVEEAVSAGLTDVLMITGRNKRPLEDHFDRNHELEEALRRKGDDGRLAKVAESNDLANIHYVRQGDPRGLGHAVLCAAEHVGDQPFAVLLGDDLIDPRDPLLARMVRAQADQGGSVIALMEVDPEQIHLYGCAAVETTADSDVVRVTGLIEKPAAADAPSNYAVIGRYVLDPAVFDVLRTTEPGRGNEIQLTDALQRLATDEALDSPVHGVVFKGRRYDTGDRGDYLRAIVRLACEREDLGADLRAWLRKYVAEEMAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NEL2</accession>
    <name>A0A0F7NEL2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_12615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019996.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_12615"/>
    <dbReference type="EnsemblBacteria" id="AKH86721">
        <property type="protein sequence ID" value="AKH86721"/>
        <property type="gene ID" value="AA958_12615"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_12615"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2650"/>
    <dbReference type="OrthoDB" id="1345207at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="260" mass="26356" checksum="9B385D264CB4C681" modified="2015-07-22" version="1">MTAAAVTAFALLGDSGGPTAPRALTSEEANRLAVTRFLNYQAGGRAVTITVPNAAGGLVISASVDYRTHTGYGVVHGTGRDTSSDGLIQWTATTVLVHPMADPPAVAPASPPASGWHRRPLQTSGMALDTSLGIALGLGSDRPENAALLPQNGAAWVGRDEVRGHRTDIMNGPDAGTGSSGKAGSSDKAGGSDKAGGSSGKTGGSDEAGTSPTVRYWIGSDGTMYRVEAGVASQPEPVVFDFDDRTYVPVKPVPGFTPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NET3</accession>
    <name>A0A0F7NET3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_26760</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_26760"/>
    <dbReference type="EnsemblBacteria" id="AKH85237">
        <property type="protein sequence ID" value="AKH85237"/>
        <property type="gene ID" value="AA958_26760"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_26760"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5630"/>
    <dbReference type="OrthoDB" id="1045165at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="5">
        <location>
            <begin position="100"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="33"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="51"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH85237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="334" mass="35179" checksum="A414E811EF5C9963" modified="2015-07-22" version="1">MLFTKALKAAGMPADKGFVSTLAQTMMTARSSESGFAGHGDLDRYPYPDGPAATPAAPVPPAAAPGPAAPPAAPPAPPAWDAGEPEIGRVGRRAASSRGRGLHGQLVQQLGQMIVSGDLGADRPLVPEEIGQRFEVSRTVVRESLRVLEAKGLVSARPNVGTRVRPVSDWNLLDPDIIEWRAFGPQREDQRRELCEMRWTIEPLAARLAAGHGRGAVQQRLTDMAEIMSHALVQGDTVTFARADAEFHGLVLQVAGNRMLEHLAGVVTAALQVSGGPAGGCDRPSEQSVTHHVHIVEALGSGDGAAAESAMRQLLGVHTEIGAGDRVVPAPREH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NF26</accession>
    <name>A0A0F7NF26_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AA958_31960</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019297.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_31960"/>
    <dbReference type="EnsemblBacteria" id="AKH86069">
        <property type="protein sequence ID" value="AKH86069"/>
        <property type="gene ID" value="AA958_31960"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_31960"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6749"/>
    <dbReference type="OrthoDB" id="768211at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="295"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="347"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="381"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="9">
        <location>
            <begin position="50"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="8">
        <location>
            <begin position="323"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="13"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AKH86069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="418" mass="42857" checksum="115FFEE85BDC924C" modified="2015-07-22" version="1">MTAPHAAAELDRAQPPVPPPPTPPKPARMTPADMLRVGGSGLRSRPMRVFLSALGIAIGIAAMIGVVGISTSSTEDLDRRLNALGTNLLTVTPGQSFSGSEASLPAESVGMIGAIPEVGNVSAVGRVDANVFRNDRIPEEQTGGLSVSAARVDLPESVGLQITEGRWLNDANSRYPAVVLGPKAAEQLGIYEAGPDAQVWLGGRWFTVVGLTAYNELVPELDSAALVGWDVAEDELGFAGTPTTIYTRTDESAVADVQSVLGATANPENPNEATVSRPSDALAAKEATDETLSGLLLGLGGVALIVGGVGVANTMVISVLERRSEIGLRRSLGATRGQIRSQFLCEALLLSALGGLGGVVLGIGVTVGYATSQDWATVVPIWAMAGGIGATLLIGGLAGFYPAVRAARLPPTEALATT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NF32</accession>
    <name>A0A0F7NF32_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Carbohydrate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_27950</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020470.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_27950"/>
    <dbReference type="EnsemblBacteria" id="AKH87075">
        <property type="protein sequence ID" value="AKH87075"/>
        <property type="gene ID" value="AA958_27950"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_27950"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5891"/>
    <dbReference type="OrthoDB" id="1619686at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FGGY_N" evidence="2">
        <location>
            <begin position="9"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="FGGY_C" evidence="3">
        <location>
            <begin position="260"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH87075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="514" mass="53231" checksum="67A305E34E060880" modified="2015-07-22" version="1">MTHPAPDAWLGIDLGTQGVRAVAADSAGHLLGTGTAPLTSDRRDGRHEQDPDEWWHAVCAAVGQARAAGADPRRIRAVAVDATSGTVTLTDRRGRAVTPALMYDDGRAAAEAEKVNEAGEAQWTRAGYRRMQRSWGLPKLRWLLDRHPRAAADGWRLAHQNDVVNRRLVGHDVPADTSNALKTGADAATVTWPDEVFADLGIPAGVLPGLVPPGTVLGEVSAAAAAETGLRAGTPVVAGMTDGCAAQLGSGATAVGSWNSVMGTTLVLKGVTADLVHDPAGVMYSHRSPAGTWLPGGASSVGAGLVAREFAGADLDRLTAGAAELLPTGLLRYPLVSPGERFPFVAPEATAFRSREAAGPAEDFAALLQGAAYVERLCFDYADLLGAPATGAVVLTGGATRNPVWNQLRADVLRRPVTLPRHAQPALGMAVLAAAALDGTGTDTDSGGAAGSPAAGGALDRAAAAMVRADRTVEPRDPYRSAHDEGYVRLVDLLARRGWLPEVVAAHARERTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NF50</accession>
    <name>A0A0F7NF50_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mobilization protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_19205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020232.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_19205"/>
    <dbReference type="EnsemblBacteria" id="AKH86896">
        <property type="protein sequence ID" value="AKH86896"/>
        <property type="gene ID" value="AA958_19205"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_19205"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4038"/>
    <dbReference type="OrthoDB" id="2020821at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519586" evidence="1">
        <location>
            <begin position="24"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="102" mass="10852" checksum="1D0A659DDA3E6692" modified="2015-07-22" version="1">MIKSAAARCHLSVAGFLARSALAAARDLDRTSAEIADEREVITALFDCRRRLGWAGSNLNQAAKALNSGADAPYLEAAVTAVRRAADTTHEAAARLIERRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFE6</accession>
    <name>A0A0F7NFE6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cytochrome P450 FAS1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_31930</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019291.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_31930"/>
    <dbReference type="EnsemblBacteria" id="AKH86063">
        <property type="protein sequence ID" value="AKH86063"/>
        <property type="gene ID" value="AA958_31930"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_31930"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6743"/>
    <dbReference type="OrthoDB" id="816674at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH86063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="387" mass="43186" checksum="20769A198D903C88" modified="2015-07-22" version="1">MVKSPEIPVHNRRDGLEPLPELRRMSRETPLLETPRDWVATGQAEVRRILGDADRFSTMPPADTEEDRRRQIQEGNLLQYDPPDHTRLRQMLTPEFTNRRMRRLEPFIEEIVAERLDALERAGRPADFMRHFAWPIPGLVSCALLGVPRDDQAELARNLDISRAGNRSRTQQMTAGKAYVGYMSQLVARKRRDPGDDLLGMLIREHGDDVSDTELTGIGTSLMAAGYENVAGTLGLGTMLLLGHPDQLALLLEKPELTDRAMEELLRYVSVIATSSPRTALADVPVGDAVIKKGDVVVCSLLAVNRAARDGAGHDGFDITREVTSHMAFGHGIHYCLGAPLTRVQLRIALPRLLHRFPGLRLAVPPEELRYRTLAPNYGVEALPVTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFF4</accession>
    <name>A0A0F7NFF4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_24255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020373.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A0F7NFF4"/>
    <dbReference type="STRING" id="444103.AA958_24255"/>
    <dbReference type="EnsemblBacteria" id="AKH87006">
        <property type="protein sequence ID" value="AKH87006"/>
        <property type="gene ID" value="AA958_24255"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_24255"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5111"/>
    <dbReference type="OrthoDB" id="1930882at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.606.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016119">
        <property type="entry name" value="Br/Cl_peroxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxi_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="SSF48317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005437218" evidence="1">
        <location>
            <begin position="23"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH87006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="498" mass="54359" checksum="C293697A01320C52" modified="2015-07-22" version="1">MLLGGGSAAALTALGHAGTAAAEPGPAAEPPPAFDLDKGNFVRDLLTVAGDSSGETQDLGPADVTLIFWIQDVMQTAWFDALAPYHPTAVGVRTRLPRRPAGESETNRNKNIAGLYATYHVVSVAYPERGYILRGLLEAIGLDPDDESEDPATPAGIGNLAGKAAVEARRRDGMNFLGDEGRRYHPQPFEDYTGYEPVNTAYKLVDPSKWQPARTPHRRRVGGGPGDKGIFTVQQFATPQLRLVEGHTFRDPGRFELPPPDHSDHTAPGRYKRAVDEILRASAALTDEQKAKAEFFSNNYQGILLATRAAAIAHDLDLDGWVHLYMTSSVAQLDNLIASWHLKHAYDAVRPFSAVRHVYGRQKVRAWGGPGKGTVELRADEWAGYLPVNDHPEYPSGSTALCAAMAQGARRFLGDDVLEWTYTFKAGSTQTEPGLVPARDIELNYGTWTTFVRDAALSRVWAGVNFTKTAERSVEFGKQFGDLAHEFVQRHVSGEAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFI7</accession>
    <name>A0A0F7NFI7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UDP-glucose 4-epimerase</fullName>
            <ecNumber evidence="5">5.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AA958_32145</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>UDP-alpha-D-glucose = UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:22168"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="5.1.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.2" evidence="5"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019331.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_32145"/>
    <dbReference type="EnsemblBacteria" id="AKH86103">
        <property type="protein sequence ID" value="AKH86103"/>
        <property type="gene ID" value="AA958_32145"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_32145"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6787"/>
    <dbReference type="OrthoDB" id="1597849at2"/>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003978">
        <property type="term" value="F:UDP-glucose 4-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005886">
        <property type="entry name" value="UDP_G4E"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01179">
        <property type="entry name" value="galE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="8">
        <location>
            <begin position="3"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH86103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="328" mass="34872" checksum="525D647100AF61FE" modified="2015-07-22" version="1">MTWLITGGAGYIGAHVVRTMAGAGERVVVLDDVSTGNPARLPADVPLVRGTFLDRLLLDRTIAEYDVTGVLHLAAKKQVGESVEQPLSYYRENVHGLGVLLEAVVAAGVRRFVLSSSAAVYGMPDVDLVTEDTPCLPINPYGETKLAGEWLLRATGRAHGLATACLRYFNVAGSAAPGLADTGVFNVVPMFFARLTAHQPMRIFGDDYPTPDGTCIRDYVHVVDLADAHLAAARRVAAPAVSGDLTVNLGSGTGVSVRELAAIVAEVTGRSGHTPEVLPRRPGDPARVVASYDLAAKELGWLPRLDVRAMVESAWAGWLHSHPEARRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFX6</accession>
    <name>A0A0F7NFX6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Branched-chain amino acid ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_34060</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_34060"/>
    <dbReference type="EnsemblBacteria" id="AKH87221">
        <property type="protein sequence ID" value="AKH87221"/>
        <property type="gene ID" value="AA958_34060"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_34060"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.7197"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015658">
        <property type="term" value="F:branched-chain amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06581">
        <property type="entry name" value="TM_PBP1_LivM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043428">
        <property type="entry name" value="LivM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30482">
        <property type="entry name" value="PTHR30482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="36"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="237"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH87221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="322" mass="33966" checksum="B8369A54CC33C8BE" modified="2015-07-22" version="1">MSGALGSKWLGLVLAVLTVALPFVNSTTYLIQIATGALIFVMLAVGLNIVVGFCGLLDLGYAAFFAIGAYTSGVLATKFGWPMIATIPVVVVVAVLGGIFIGGPTLRLRSDYLAIVTLGFGEIIRITANNIDFTGGPNGLYGIPGFGDFGLRSDIVVYWVSAVVVCAAVLFSSRLGRGRLGRAWRFVREDEDAAEAMGIHTYKVKFAAYIAGAVFGGIAGVLFAAQQTAISPPSFNFLWSALILMAVVLGGMGSTPGVVLGALIISLLPELLRGAENWRYLIFGLLLIVVMIFRPQGLLPARTGEPKRCERRGPTTTQEGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NG71</accession>
    <name>A0A0F7NG71_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_33465</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019546.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_33465"/>
    <dbReference type="EnsemblBacteria" id="AKH86323">
        <property type="protein sequence ID" value="AKH86323"/>
        <property type="gene ID" value="AA958_33465"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_33465"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.7068"/>
    <dbReference type="OrthoDB" id="1024978at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="2">
        <location>
            <begin position="35"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH86323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="503" mass="52937" checksum="EABA06AAA232078E" modified="2015-07-22" version="1">MAEWTSAVGAVQLARLLRSQESAGAVALDRPGRRVPAYRALADGVRLLVLEGRIPVATRLPAERELAAALGVSRTTIAAAYEHLRAAGFLESRRGAGSWTSVPAGHPLPTRGLEPLPPDATGSMIDLGCAALPAPEPWLTRAMHGALEQLPLYAHTHGDYPAGLPGLRAAIAERYTARGVPTMPEQIMITTGAMGAMIALCRLFAGRGERIAVDSPSYANILQLMREDGARLVPVAMGEGLTGWDVETWRQTLRDAAPRLAYVIPDYHNPTGALADDDQRRALVDAARRAGTVVVADETMSELRLDDTGERPRPVAAYDPAGSTVVTVGSASKAFWAGLRIGWVRAAPEVIRSLVSARAYADLGSPVVEQLATTWLLEGGGWAAATGLRRSQARANRDAIVAALRRHLPDWEYTVPHGGLTLWVRTGGLSGSRIAEAGERVGVRIPSGPRFGVGGAFEGYVRLPFTVTGAVAEEAVGRLAAAARAVSEGGGPVAAEPAGAFIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NGC2</accession>
    <name>A0A0F7NGC2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Beta-mannanase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_33630</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019575.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_33630"/>
    <dbReference type="EnsemblBacteria" id="AKH86353">
        <property type="protein sequence ID" value="AKH86353"/>
        <property type="gene ID" value="AA958_33630"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_33630"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.7101"/>
    <dbReference type="OrthoDB" id="1395441at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018087">
        <property type="entry name" value="Glyco_hydro_5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00659">
        <property type="entry name" value="GLYCOSYL_HYDROL_F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519621" evidence="4">
        <location>
            <begin position="47"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="Cellulase" evidence="5">
        <location>
            <begin position="64"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH86353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="352" mass="37793" checksum="EF62C7D4B92B19D2" modified="2015-07-22" version="1">MSAPRTTPPTARGRRRRGGTRTGRALLAALLGLAAAVAGFGPGAQAEPAGAAAGLHTEGGRLLEGNGNDFVLRGVNHPHAWYTGELDSLREIKQLGANSVRVVLATGDRWPRSDTADVDNVVSQCKANRLICVLEVHDTTGYGEEDAAVSLDRAADYWISVRDALVGEEDYVIVNLGNEPHGNQGYERWTADTRGAIARLRAAGLRHTLMADAPNWGQDWTNTMRTNARAVADSDPQGDTLFSIHMYGVYDTAAEIEDYLTSFTEAGLPIAVGEFGHDHSDGNPDEDAIMRLTRELGLGYLGWSYSGNGGGVEYLDMVRNFDPAALTDWGRRFFQGQDGIAATAKEATVYGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NGD0</accession>
    <name>A0A0F7NGD0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Gluconate permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_02470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019733.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_02470"/>
    <dbReference type="EnsemblBacteria" id="AKH86509">
        <property type="protein sequence ID" value="AKH86509"/>
        <property type="gene ID" value="AA958_02470"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_02470"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.528"/>
    <dbReference type="OrthoDB" id="1585405at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015128">
        <property type="term" value="F:gluconate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003474">
        <property type="entry name" value="Glcn_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30354">
        <property type="entry name" value="PTHR30354"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02447">
        <property type="entry name" value="GntP_permease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002746">
        <property type="entry name" value="Gluconate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="266"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="307"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="343"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="384"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="423"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="465"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH86509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="490" mass="49425" checksum="E59584BAAD15C521" modified="2015-07-22" version="1">MAALVLGIATIIVIVLRTRLDAFVALLVASLVTGFVAGAPATETLDSITAGFGSTLGSIGIVIGLGVGLGKILEVSGAADALARAFVRAFGKGREPWAMGTTGAVVSIPVFCDSGYVIMNPLARSIARVKRAGYVTLALALGCGMTLTHHLVPPTPGPLGVAGILGAELGALVLAGLAFSAVLLPIVIAYARWMGPKLESEVSDEVREAVYGKAAVAAGAGPGSAGAPAGLSENDFADEPEPERDPAAALGTPPPGAKPHRMNPGLATLPLLVPLLLIIANTVASAIDQNRQGAVGSDDYEPSALPKALAFIGSPVVALLIGIVLAVYVLLPRWTTRSQVGGWLSEAAASAGLIILITGAGGALGQVLRDTGVGDELAEAISSWSLPGVLVPFLIASLVRVAQGSGTVAMITAASVTAPLIDGLGISALLAALACCAGSMVFSYFNDSYFWVVTRFTGLDGIAAIRGWSGITTAVWLGSLPLLLVASTFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NGI0</accession>
    <name>A0A0F7NGI0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_33895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019620.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_33895"/>
    <dbReference type="EnsemblBacteria" id="AKH86398">
        <property type="protein sequence ID" value="AKH86398"/>
        <property type="gene ID" value="AA958_33895"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_33895"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.7157"/>
    <dbReference type="OrthoDB" id="1513550at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008734">
        <property type="term" value="F:L-aspartate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005288">
        <property type="entry name" value="NadB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42716">
        <property type="entry name" value="PTHR42716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="533" mass="57976" checksum="959BC6DE890284CA" modified="2015-07-22" version="1">MTELRTDIAVVGGGLGGVAAALAAARSGLRVLLTEEYDWVGGQLTVQGTPPDEHPWIEQFGCTASYRRLRDGIRDYYRHWYPLSAAARRRPALNPGAGRVSALCAEPSAAHAVLRAMLAPHRASGLLDLRLGHRPVAATTDGDAVTSVTLRDLDSGEDVTVTAAYFLDATETGELLPLTGTEYVTGFESQADTGEPSAPARRQPLNMQAASWCFAVEHRAGEDHTIDKPDDYGFWRDYRPPYWPDRMFSMVAPKPQTLRPATRVLIPDPAPGEPALQGLAGDLDLWAFRRVLARSSFEDGALAGDVVIVNWPMIDYVEGPLYEVEPAAAARHLAGARQMSLSFLYWMQTEMPRPDGSTGLPGLRLRGDVVGTADGLCMGPYIRESRRIRAVYTVTEQDVSLAIRGDRGAVAYEDSVGIGSYRIDLHPSTGGDNYIDVASSPFRIPLGALLPERMCNLLPAAKNIGTTHLTNGCYRLHPVEWNAGEAAGLLAAYCLRHRTTPHQVRAQPARLADYQSALTGHGVEIAWPDIRGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NHQ3</accession>
    <name>A0A0F7NHQ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_33205</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019502.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86277">
        <property type="protein sequence ID" value="AKH86277"/>
        <property type="gene ID" value="AA958_33205"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_33205"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.7014"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018391">
        <property type="entry name" value="PQQ_beta_propeller_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002372">
        <property type="entry name" value="PQQ_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13360">
        <property type="entry name" value="PQQ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00564">
        <property type="entry name" value="PQQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH86277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="450" mass="46859" checksum="7869C293C67AE196" modified="2015-07-22" version="1">MAAPGMPAQPGQAAPPPYAYPAPPPPGSGGGKKAVGIVLSVLLVLAVLGGGAAVVFLSDDDGGGGTSAQDELPANALEQLWSAPLEGSHVAAGDSSSLPGMWPAGDHVVYGDEDGGMRAYDVRSGKEKWRVKPPKRAGELCAMSRGISPGGIGAVAFDAGGDDCAYLAAVEVDTGTLLWSENLADEYGTTNPVLTVNDSTISTNIGTYVNNWNAKGGGPGLDFTSRGRECDSSLVLGDEHAVGSSECTDVSPRHQLTVLDTRGGEDPWRFPGVDLDVLRVLGENPLTVLLQDDDENRFVQSFTDDGGQGKLVPLTGGLAELQFEEHTTFVTEDGVLVAEYGDNVHFAAVDLKSGELLWKTPKKAWLQMIGYDATDGRLIASAKPGEGFHLELTEYDVRSGKPEVIGALAVKGQSMGSPATATYAWDGSTVYVVAENAKGQAVLRAFRGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NHX5</accession>
    <name>A0A0F7NHX5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cysteine desulfurase</fullName>
            <ecNumber evidence="4">2.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AA958_18735</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[sulfur carrier]-H + L-cysteine = [sulfur carrier]-SH + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:43892"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="EC" id="2.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.7" evidence="4"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020208.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_18735"/>
    <dbReference type="EnsemblBacteria" id="AKH86878">
        <property type="protein sequence ID" value="AKH86878"/>
        <property type="gene ID" value="AA958_18735"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_18735"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3929"/>
    <dbReference type="OrthoDB" id="839689at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044571">
        <property type="term" value="P:[2Fe-2S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010240">
        <property type="entry name" value="Cys_deSase_IscS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016454">
        <property type="entry name" value="Cysteine_dSase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11601:SF34">
        <property type="entry name" value="PTHR11601:SF34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005572">
        <property type="entry name" value="NifS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="9">
        <location>
            <begin position="11"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AKH86878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="391" mass="40135" checksum="8951C535BD67CDAD" modified="2015-07-22" version="1">MSEPHGSDLSYFDYNATAPIRPEARAAVAAAMQSVGNASSMHQPGRQAAHRVDIARRQLADLLGCSPGEIIFTSGATEANNLALRAAFTGGSPLVTSPVEHLAVLETARAVTTGSPEDLVLLPVGGDGLVDLDALEQVSVARSGGVVSLMAANNETGVLTDLRVVAKAVRESGALVHTDATQLIGRVPVEVAELDVDLLSLSAHKFGGPQGVGALYVRRGSPLPHRPLLVGGGQERGWRAGTLNVAGIIGMGAAAEAAARSLGEEAERVAAMRDRLECLVVGALPECRINGRRDQRLPGVTSITFPGVPADAVLAAMPDVAASDGSACASGAPTPSHVLLAMGLSRADADSTIRFSLGYATTDAEIEHAARAVKRAVTQVRAALAEADGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NIT7</accession>
    <name>A0A0F7NIT7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Collagen-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_12620</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_12620"/>
    <dbReference type="EnsemblBacteria" id="AKH86722">
        <property type="protein sequence ID" value="AKH86722"/>
        <property type="gene ID" value="AA958_12620"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_12620"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2651"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033764">
        <property type="entry name" value="Sdr_B"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17210">
        <property type="entry name" value="SdrD_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0176">Collagen</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="793"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="domain" description="SdrD_B" evidence="4">
        <location>
            <begin position="590"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="731"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="733"/>
            <end position="771"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH86722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="819" mass="85076" checksum="64B6C66FEE962B7A" modified="2015-07-22" version="1">MTGAGQAGASASDGSLTVQVLRDFFGTGVINSTMDVPQRGMKVGVTDPAGHRVSGVTDATGKVVVPPSSELTGGRYRVDVTVPAPYSDYLRAAPASTAPNHFDSFTTFVDVSDGKDDSVITGVWDPADYALPDSRYFVPVQSGAGGTETRALVAFGTDARGNCPDQEPCPEVLTTQDQVGTTYGLAYDRHRDQLFQSSFARRYTEYGPDGGDAIYTVPAHGGAPKLFAEVPDATETPHDTGNLIKDAGFTDAPGKESIGSLDLSDDGSTLYAVNLLTRSLVSFDATKPTASAPEATVPIPDPGCASPDDWRPFSVATHNGTLHVGGVCSAESTQDRADLKAVVATYDGEDFTTVLSQPLDFERGAVLTGRSGYDQVNHWNPWNTDLEDWDDRNVDGPMIDPQPELAGLAFTRDGSLILGFRDRFMDVVSWGGLDPRPGNDTPQNGMSGGDITMACATPTGGFEWEGTGNCPDHATDPTLDGAQPGGVVEYFPGDFFPNGGSATQPGPHQESSLGSVAYIPQQQWAVSTQMDPTGQVITSGTGYYDVDTGLGPGNDPAANAYQFVGPNQNGFGKAGGLGDIAYAAANAPIQIGNVVWFDGDHNGVQDAGHVLLPDATVNLLDADGEKVATTTTDAAGEYYFGGAGAEYELTPGAEYTVQFDVCTADTGEVPGRPAADDLRFTLPRAGEDRVHDSNVTPPDNGRLCNGYAPVTAPARPGGVDHTIDAGVYVPKEALPTPAPPTPTPPTPTPPATEPPAPAPEPPTPAAPHTPAPAGDRKPGGSLAGTGSSGLGELLALAALLLGAGAAVVLVSRHRRARHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NJ44</accession>
    <name>A0A0F7NJ44_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phenylacetic acid degradation protein PaaD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_16395</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_16395"/>
    <dbReference type="EnsemblBacteria" id="AKH86822">
        <property type="protein sequence ID" value="AKH86822"/>
        <property type="gene ID" value="AA958_16395"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_16395"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3451"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002744">
        <property type="entry name" value="MIP18-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011883">
        <property type="entry name" value="PA_CoA_Oase4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01883">
        <property type="entry name" value="FeS_assembly_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="SSF117916"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02159">
        <property type="entry name" value="PA_CoA_Oxy4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FeS_assembly_P" evidence="2">
        <location>
            <begin position="19"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH86822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="206" mass="21696" checksum="EB6D106D729F15A4" modified="2015-07-22" version="1">MTDAPGDTPLEERLRELAGSVPDPELPMLTLAELGVVRGVRRTGAAAVEVELTPTYTGCPAVESMAEDIERVLRERGGMAEVRVRRVLAPPWTTDDITPEGRRKLAESGIAPPRTTRPEGPVPVTFRPRRAPATPSPGDGSAPAPGRAGSMTPGTAVPVAPAAGVPCPHCGSAETELLSPFSSTACKALRRCTACLEPFDHFKELT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NJB3</accession>
    <name>A0A0F7NJB3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_18865</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020212.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86882">
        <property type="protein sequence ID" value="AKH86882"/>
        <property type="gene ID" value="AA958_18865"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_18865"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3960"/>
    <dbReference type="OrthoDB" id="1057317at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005523">
        <property type="entry name" value="DUF317"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03771">
        <property type="entry name" value="SPDY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SPDY" evidence="2">
        <location>
            <begin position="61"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="SPDY" evidence="2">
        <location>
            <begin position="144"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH86882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="273" mass="30018" checksum="E176270EBB3177A8" modified="2015-07-22" version="1">MPLTERLTAAFADTHAWQIPYDTSPRHLAGPGDPRHVTHGLAAAGWRTVSDRLGADIVLRSPDYRYRLQHTPAAHSTSRWWYLQADTTDTAFGWHANLSGLAPAEVIASLTDTLVSPTIVDPPGIISTLESAGWRVSDPATAASPDGMCRVELRNQEFHDTPHWHVETREPRSGHYDGPRIWNAWFSDYMPEYLVAAFVTALADPAPLHRAMFDSTVHYGAASTPSALTPEDVVKAHATRITSLHRAARATRRQKKPAADPVKTGTARAAARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NJI9</accession>
    <name>A0A0F7NJI9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_21615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_21615"/>
    <dbReference type="EnsemblBacteria" id="AKH86947">
        <property type="protein sequence ID" value="AKH86947"/>
        <property type="gene ID" value="AA958_21615"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_21615"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4552"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="248"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="381" mass="38459" checksum="161FF5BC52A9535F" modified="2015-07-22" version="1">MPAGVAYSPGASRQWVSDELTRSADTLAARGAAAGGTWPASLWRRSLYVIGAGLLALLLVIGLTALGPGWTRARTAALLAAVLTAGLLAGAAWLNRARGGLLAPVVGEDGRLSTGRVVAGAWTLLAGYALLHLALALALADGSAARDRLLDGLGWSGSGAGPGGAAGLVVTVAAVWAAALGSRAVVAHRLRSGGLTKTRAARPRGADLLTDDAGRAAAVDVQYVVVSAAALLFALVQLGRRPEQLPGLPWGVAALVAVSAAVHLAARLVDGGRPAVLSVVRVREPGDLHTAIRTGDDIEVRGTGFVPPGAESPELLARVVVRIGAVHVHVPLVPVPGGFANPAATRLTVPVPVDVEPGRTELRVVTAGGAESAPYLLDIVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A097H0W5</accession>
    <name>A0A097H0W5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Putative N-acetylmannosamine-6-phosphate 2-epimerase</fullName>
            <ecNumber evidence="5">5.1.3.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ManNAc-6-P epimerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">cnq721</name>
        <name evidence="5" type="synonym">nanE</name>
        <name evidence="7" type="ORF">AA958_30810</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="ChemBioChem" volume="15" first="2385" last="2392">
            <title>A Membrane-Bound Prenyltransferase Catalyzes the O-Prenylation of 1,6-Dihydroxyphenazine in the Marine Bacterium Streptomyces sp. CNQ-509.</title>
            <authorList>
                <person name="Zeyhle P."/>
                <person name="Bauer J.S."/>
                <person name="Steimle M."/>
                <person name="Leipoldt F."/>
                <person name="Rosch M."/>
                <person name="Kalinowski J."/>
                <person name="Gross H."/>
                <person name="Heide L."/>
            </authorList>
            <dbReference type="PubMed" id="25224759"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CNQ-509</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 5">Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>an N-acyl-D-glucosamine 6-phosphate = an N-acyl-D-mannosamine 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23932"/>
            <dbReference type="ChEBI" id="CHEBI:57599"/>
            <dbReference type="ChEBI" id="CHEBI:57666"/>
            <dbReference type="EC" id="5.1.3.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 5">Amino-sugar metabolism; N-acetylneuraminate degradation; D-fructose 6-phosphate from N-acetylneuraminate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the NanE family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.9" evidence="5"/>
    <dbReference type="EMBL" id="KJ451627">
        <property type="protein sequence ID" value="AIT42111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019105.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_30810"/>
    <dbReference type="EnsemblBacteria" id="AKH85877">
        <property type="protein sequence ID" value="AKH85877"/>
        <property type="gene ID" value="AA958_30810"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_30810"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6512"/>
    <dbReference type="OrthoDB" id="1710586at2"/>
    <dbReference type="UniPathway" id="UPA00629">
        <property type="reaction ID" value="UER00682"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047465">
        <property type="term" value="F:N-acylglucosamine-6-phosphate 2-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009385">
        <property type="term" value="F:N-acylmannosamine-6-phosphate 2-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006051">
        <property type="term" value="P:N-acetylmannosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019262">
        <property type="term" value="P:N-acetylneuraminate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04729">
        <property type="entry name" value="NanE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01235">
        <property type="entry name" value="ManNAc6P_epimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007260">
        <property type="entry name" value="NanE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36204">
        <property type="entry name" value="PTHR36204"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04131">
        <property type="entry name" value="NanE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIT42111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH85877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="237" mass="24078" checksum="004D827995CA3EF9" modified="2015-01-07" version="1">MSARSDGGGRDGALLARLRGRLVVSCQAYPGEPLRDPDTMRRMALAVLDGGAAGIRAQGLADLRAIRAATGAPLIGLWKDGDGGVVITPTAAHARAVAEAGADIVAVDATDRPRPDGRDVAESFEAVRRAGRLVMADVSTYEEGLRAADAGADLIGTTLSGYTGRSPAPGTGPDLGLVERLAAAVRVPVLAEGRIGTPAEAAEALAHGAYAVVVGTAITHPTTLTRRFTAALDATRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MXC7</accession>
    <name>A0A0F7MXC7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AA958_00445</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH80885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH80885">
        <property type="protein sequence ID" value="AKH80885"/>
        <property type="gene ID" value="AA958_00445"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_00445"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.105"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
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        <property type="entry name" value="Prot_kinase_dom"/>
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    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
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        <property type="match status" value="1"/>
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        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_ST"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
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        <location>
            <begin position="18"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="277"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="348"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="361"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH80885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="531" mass="57130" checksum="3E63DA935AC9360A" modified="2015-07-22" version="1">MGDGTAADGPGRLVAGRYRLLERIGRGGMGTVWHAEDEVLGRQVALKKLHLPPHLKDGERATLFERTRREARSAARITHPNVVVVHDVVDDEGLPCIVMEYVPAPALDEVLKKDGPLETAEAVRIGIGVIAALRAAHAAGVLHRDVKPGNVLLGADGRVVLTDFGIAVVADTSTLTRTGEMVGSVDFCAPERLKGADPAPSSDLWALGATLYQAVQGRPPFRRATPLETAYAIAVDPLEQPVGGRALGPLIAELLAKDPEARPSAPEVERRLRHLAGAGPATDARPTVPELPATPPPAPPAYGTDAATVRHGRGRGRRTGVWVTAMAVTVPALLAGAYFALPDEDKDAGTAAEKKPSASTTPKPKPKPDPAPAPVPEGYQLVREEEFEISFPVPEGWTRQDLEEEGEGVAYIDPTGMAGLRVVALDYASTDPLQHFKDNETKSIQEGKLPGYRQLRMQSTTYRGMPAAIWEFTWQGRAREWRARDLGFGRPGEKEYAIYLSTPSADWDRHEPVFENVSDGIRLKTGASGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MY14</accession>
    <name>A0A0F7MY14_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP/GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_01950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014499.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_01950"/>
    <dbReference type="EnsemblBacteria" id="AKH81135">
        <property type="protein sequence ID" value="AKH81135"/>
        <property type="gene ID" value="AA958_01950"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_01950"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.421"/>
    <dbReference type="OrthoDB" id="1538300at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="168"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="318" mass="34617" checksum="17044E73600FE58B" modified="2015-07-22" version="1">MIVWLNGAWDTGLRRVAHELVELTPGSILYDPELTGGQLRALLPQKRLDEVGDEQELPAWRRLVVETAAALLAEADGPLVVPAALWREEHRDEIFGRLASRGFEVRHLLVSFDETILHAGPFPHWLTGDAHIVHAAGQSAREAAEEIASCLRAGAGYCDIVQNSEPTGETLAAGVLLFDEDDRVLLVDPTYKPGWEFPGGVVEAGEAPARGGVREVAEELGLRLRRAPRLLVVDWEPPRPPEYGGLRLLYDGGRLGPAEAAGVLLPGPELRAWRFVTEDEAGGLLPSVRFSRLRWALRARRRGAAVYLEGGAPVADGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MYB7</accession>
    <name>A0A0F7MYB7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11 12">Xylose isomerase</fullName>
            <ecNumber evidence="4 11 12">5.3.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">xylA</name>
        <name evidence="15" type="ORF">AA958_02445</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 11 12">
            <text>alpha-D-xylose = alpha-D-xylulofuranose</text>
            <dbReference type="Rhea" id="RHEA:22816"/>
            <dbReference type="ChEBI" id="CHEBI:28518"/>
            <dbReference type="ChEBI" id="CHEBI:188998"/>
            <dbReference type="EC" id="5.3.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 11 13">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11 12">Belongs to the xylose isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.5" evidence="4 11 12"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014583.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_02445"/>
    <dbReference type="EnsemblBacteria" id="AKH81220">
        <property type="protein sequence ID" value="AKH81220"/>
        <property type="gene ID" value="AA958_02445"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_02445"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.523"/>
    <dbReference type="OrthoDB" id="481478at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009045">
        <property type="term" value="F:xylose isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00455">
        <property type="entry name" value="Xylose_isom_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013453">
        <property type="entry name" value="XylA_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001998">
        <property type="entry name" value="Xylose_isomerase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00688">
        <property type="entry name" value="XYLOSISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02631">
        <property type="entry name" value="xylA_Arthro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51415">
        <property type="entry name" value="XYLOSE_ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11 12" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 11 12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 11 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 12" id="KW-0859">Xylose metabolism</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="14">
        <location>
            <begin position="41"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="217"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AKH81220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="387" mass="42712" checksum="4C97CDD5ECDA798C" modified="2015-07-22" version="1">MSYTPTPEDKFSFGLWTVGWQGRDPFGDATREPLDPVESVRRLADLGAYGVTFHDDDLIPFGASETERESHVKRFRQALDATGMAVPAATTNLFTHPVFKDGAFTANDRDVRRYALRKTIRNIDLAVELGAKVYVAWGGREGAESGAAKDVRVALDRMKEAFDLLGEYVTGQGYDLKFAIEPKPNEPRGDILLPTVGHVLAFIERLERPELYGVNPEVGHEQMAGLNFPHGIAQALWAEKLFHIDLNGQNGIKYDQDLRFGAGDVRAAFWLVDLLETAGYAGPKTFDFKPPRTEDKEGVWASAAGCMRNYLILKERAAAFRADPAVQEALRASRLDELAQPTADDSGLAGLLADRGAYEDFDPEAAARRGMAFEHLDQLAMDHLLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MZ22</accession>
    <name>A0A0F7MZ22_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptide synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_04235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014885.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_04235"/>
    <dbReference type="EnsemblBacteria" id="AKH81530">
        <property type="protein sequence ID" value="AKH81530"/>
        <property type="gene ID" value="AA958_04235"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_04235"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.888"/>
    <dbReference type="OrthoDB" id="572620at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05931">
        <property type="entry name" value="FAAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040097">
        <property type="entry name" value="FAAL/FAAC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="17"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="584" mass="63158" checksum="2497A0D221D05D7B" modified="2015-07-22" version="1">MTEPLLPDEPSAVHLLRRHAGERPGRAAVTFVHDHDAADGARTLDYAALDAEARRVASWLQERCAPGDRVLLLHPPGLPFVTAFLGCVYAGTIAVPSPMPGQFQYQQRRVTGIALDAGVSVALTDTGQVDEARRWLEAEGLDFTVAASDGAYFGAADRWRDPAAAHRDLVMLQYTSGSTGDPKGVMVDHGNLLHNADSLRRALGLTEETNFGGWIPLYHDMGLMGQLLPSLFLGSSCALMSPMAFLKRPHQWLNLIDRYDLGYSAAPNFAYELCVRRVTDAQLEQLDLSGWRFAANGSEPIQPSTVRDFADRFAPAGFRAEALAPCYGMAEATVYVSGLAGRPPRITAVDSDALEKHVLQPPLPSGPVRELVGCGDVPDFEVRIVDEGGTVLPDGTTGEIWLRGPSVATGYWGRPDATEETFGARTADGAGPFLRTGDLGALQDGEIYVTGRSKDLLIVHGRNLYPQDVEHALRLRHPALATLAGTAFTVSVPQEEVVVLHEVRGRFTDEQYQALARDMRTTVYQEFGVRTAGLVLLRPGAVRKTTSGKVQRAEMRRLFLDGALTPVHTHLEAAVGALVSGEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0D5</accession>
    <name>A0A0F7N0D5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ATP-dependent DNA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_07440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015440.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_07440"/>
    <dbReference type="EnsemblBacteria" id="AKH82090">
        <property type="protein sequence ID" value="AKH82090"/>
        <property type="gene ID" value="AA958_07440"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_07440"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1559"/>
    <dbReference type="OrthoDB" id="2061599at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014145">
        <property type="entry name" value="LigD_pol_dom"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02778">
        <property type="entry name" value="ligD_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH82090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="307" mass="33875" checksum="F777E91244C27B66" modified="2015-07-22" version="1">MPVTEVEGRRLKLSNLDKVLWPEYGFTKGEALHYYAQVADVLLPHVRDRAASFLRFPDGVDGERFFAKNAPAGTPEWVSVADVELTRSTVHHVLVQDLPTLLWAANLAALELHVPQWKAVDPGAAPAAPVRADERLADRIVFDLDPGAPATVVECCRAALLVREALRADGLDAWPKTSGSKGLHLYVPLAPASAEATSAYAKSLARRLEKEHPELILHRMARKLRPRKVFVDWSQNSRAKTTVAPYVLRAQARPTVSTPLTWDEVEACADPDELVFLPGDVTERIATHGDLLAPLLDDHFDLPDMTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0M5</accession>
    <name>A0A0F7N0M5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_04280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014891.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH81536">
        <property type="protein sequence ID" value="AKH81536"/>
        <property type="gene ID" value="AA958_04280"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_04280"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.898"/>
    <dbReference type="OrthoDB" id="1412431at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="SSF50969"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002518941" evidence="2">
        <location>
            <begin position="23"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH81536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="436" mass="45612" checksum="AD99E12D632C07AF" modified="2015-07-22" version="1">MSTRTAISFRALAAVALLSLIAAGCGGGDGDGHERRNPPQSSDTSGEAEEPPPATAFATEAAFSLETGPVRHPPVALHRQNAWVAGETGLTLVDLATGDETTRLKPRRQPLHEAWPESAGRRDEDRAAELEKQGAQRRLPRPLLTRIGGTPAVVAAVPVKGERQDPAVEILAANAETGERLWGLLVEPGVLAGENAEGLSAPVLHAHDGTAVVQVAKADRVLGSLGIDLDGPELVWEEDEFLAMAGSGDDLAGMSFPDGGGIRLLGAVLTDGAHTWSEDISKYASIAPCGPWLAVEDFDDDRGPLLIEMDSGDVTHTRDDGLVSGMSCWEGEGGTTVVLASNGEGDEGDEERGGAIGLDATSGEVLWRLRHGKWEGRVSASYEDRLYLKAGEGLVVRDARTGRVLGNVPGIAPQQVNGYAGLIAAGDGVDVHPAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0N0</accession>
    <name>A0A0F7N0N0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_00550</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH80904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014270.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_00550"/>
    <dbReference type="EnsemblBacteria" id="AKH80904">
        <property type="protein sequence ID" value="AKH80904"/>
        <property type="gene ID" value="AA958_00550"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_00550"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.129"/>
    <dbReference type="OrthoDB" id="377638at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="2"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="377"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH80904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="462" mass="48314" checksum="0A034A54579BCF56" modified="2015-07-22" version="1">MSYRDLLAMARTAEKSIAALRIPEGNPVAVVAAKSPESIAVVLACMHTARPVLVPAADVTGKPLDGLLAETGALVLPEPRALTTGTAGPAVAGKPAESRVPEGTALILTTSGSTGFPKAVPLPAAAIGAFVEWAAATFRIRVGTCVLSYAPLNFDLSLFDVWTTLSHGGQVALVAQDRAARPGHLRTLLRQCPVHVVQGVPMLFQLLAATERHPGGDEFSSVADVLVTGDSLSSAGLAALPVLFPRARMHNVYGCTETNDTFVHEMEPDGDLGRYGAVPIGRPVEGVAADIVTDDGTVLEGPGHGELIVTSPFQTSGYLDPAQHAKSFVGHPDGVTPGPYYRTGDLVTRHPDGALTLDGRSDFLVKIHGICINTAAVEGALRSHPEVADAVVFALPDERTGRRLHAVVHRAAGSMLNSLRLREHVAAELPRAGIPSGIEFVDAPLPRTATGKIDRRSVANSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0Q6</accession>
    <name>A0A0F7N0Q6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_04510</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014931.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_04510"/>
    <dbReference type="EnsemblBacteria" id="AKH81576">
        <property type="protein sequence ID" value="AKH81576"/>
        <property type="gene ID" value="AA958_04510"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_04510"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.951"/>
    <dbReference type="OrthoDB" id="1848512at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="DUF202" evidence="6">
        <location>
            <begin position="29"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH81576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="132" mass="14317" checksum="BD324294A6EB6124" modified="2015-07-22" version="1">MSDPERPSAVRLWFSPRRLRAEGRTPDYRFSLANERTFLAWVRTALALVGGGIAADQFLTEMSRPFRTAIAAVLLAGGAVCAVRAVNHWIRCERAMRRGEDLPESRFPGLLAVGTAVAAAVLIVVVLVGAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0R8</accession>
    <name>A0A0F7N0R8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lipid II isoglutaminyl synthase (glutamine-hydrolyzing) subunit MurT</fullName>
            <ecNumber evidence="1">6.3.5.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">murT</name>
        <name evidence="4" type="ORF">AA958_00820</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The lipid II isoglutaminyl synthase complex catalyzes the formation of alpha-D-isoglutamine in the cell wall lipid II stem peptide. The MurT subunit catalyzes the ATP-dependent amidation of D-glutamate residue of lipid II, converting it to an isoglutamine residue.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H2O + L-glutamine = ADP + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:57928"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:62233"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = ADP + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-O-P-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate</text>
            <dbReference type="Rhea" id="RHEA:59488"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:143132"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-O-P-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + NH4(+) = beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:57932"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:62233"/>
            <dbReference type="ChEBI" id="CHEBI:143132"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a heterodimer with GatD.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MurCDEF family. MurT subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.13" evidence="1"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH80949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014315.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_00820"/>
    <dbReference type="EnsemblBacteria" id="AKH80949">
        <property type="protein sequence ID" value="AKH80949"/>
        <property type="gene ID" value="AA958_00820"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_00820"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.184"/>
    <dbReference type="OrthoDB" id="1861122at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140282">
        <property type="term" value="F:carbon-nitrogen ligase activity on lipid II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02214">
        <property type="entry name" value="Lipid_II_synth_MurT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043703">
        <property type="entry name" value="Lipid_II_synth_MurT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013564">
        <property type="entry name" value="MurT_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08353">
        <property type="entry name" value="MurT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0133">Cell shape</keyword>
    <keyword evidence="1" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="1 4" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Mur_ligase_M" evidence="2">
        <location>
            <begin position="65"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="MurT_C" evidence="3">
        <location>
            <begin position="304"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="338"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH80949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="412" mass="43602" checksum="2B81A0A127B1600A" modified="2015-07-22" version="1">MAGNTEPLSPRSKLAVTAGRAAAAVSRAAGKGSGSVIGGKVALRLDPDLLGRLAGHLDVVLVSATNGKTTTTRLIAEALRASGPVVSNALGANMPAGITSALAGGSDARYGVIEVDEKYLAGVARDVTPKAIALLNLSRDQLDRAAETRMLAERWREGLAGNKALVVANADDPLVVWAASSSPNVVWVAVGQEWKDDAWSCPSCGGVLQRPGEDWLCAECGFRRPVPSWALSGEHVLDPHGAAWPIRLQLPGRANRANATTAAAVAAAFGVHPQTALERMWEVTAVAGRYDTVQFGGRDLRLLLAKNPAGWLETFSLIDPPPTPVVLSVNARGADGTDTSWLWDVDYTRLTGHPLYVIGDRKLDLAVRLEVANQSFRVCEHVDEAVAAAPPGRIEVIANYTAFQDLRRRVGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0V5</accession>
    <name>A0A0F7N0V5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidoglycan-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_08430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015604.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_08430"/>
    <dbReference type="EnsemblBacteria" id="AKH82255">
        <property type="protein sequence ID" value="AKH82255"/>
        <property type="gene ID" value="AA958_08430"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_08430"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1780"/>
    <dbReference type="OrthoDB" id="1584918at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036505">
        <property type="entry name" value="Amidase/PGRP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002502">
        <property type="entry name" value="Amidase_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01510">
        <property type="entry name" value="Amidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00644">
        <property type="entry name" value="Ami_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55846">
        <property type="entry name" value="SSF55846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetylmuramoyl-L-alanine amidase" evidence="2">
        <location>
            <begin position="27"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH82255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="217" mass="23356" checksum="95C3CD44C7F7DFE6" modified="2015-07-22" version="1">MAEPLSAAVVLRALKREGLTTVEHGEWRTHNRNGVGPWGPVHGVVLHHTATSGTDDSVRLCYRGRSDLPGPLCHGVIDKSGRVHLVGHGRANHAGLGDDEVLRAVIAERYGERPPSPNEQNTDGNARFYGFECINLGDGEDLWPDAQLEAAERAAAALCRAHGWQAKSVIGHKEWTDQKIDPVGFGMPGMRERIAKRLAGKPEGEPPTPPDPSGSAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0W2</accession>
    <name>A0A0F7N0W2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AA958_04865</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_04865"/>
    <dbReference type="EnsemblBacteria" id="AKH81636">
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        <property type="gene ID" value="AA958_04865"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_04865"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1024"/>
    <dbReference type="OrthoDB" id="1179151at2"/>
    <dbReference type="Proteomes" id="UP000034283">
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    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
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        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
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    </feature>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
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            <end position="158"/>
        </location>
    </feature>
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            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="217"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="333"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
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            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="387"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
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            <begin position="413"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
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            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    <evidence type="ECO:0000259" key="11">
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        </source>
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    <evidence type="ECO:0000313" key="12">
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        </source>
    </evidence>
    <sequence length="1018" mass="102358" checksum="E92F86877420E05D" modified="2015-07-22" version="1">MSLTYELTLAGLAVGSAAALSGIGVVVTYRATGVLNLAHGAVAMVTAYVMRQLAVGWNWPLWAAAAVSLLVVAPGIGLLMGRFVFRPLSVLQSGAAGAGGAQALVASLGVFVLLMGAAGLLWGTGARTDAPELLPSDPWVQLGTAVVLASAVAAVTRWTRFGRELRAVVDNRRLAALSGIDADRVADAGWAFGTFTAGVTGVLLAPEYRLDPYGLPLLVMAVIGVAVAAGLRSLPAVVAVALAVGVAQAQLTRLHPPGWGEQLVQALGANLFAVLLLVAALALPRLRAGSGDGFLRVPADTLDSAGDGRTWLVAGVLFLLPLGFAGPDLTTSVQVPALAVVLLSLVVVTGRGGQVSLGQAAYAGLGALFTALLAAGRFPGLPALPELVALGVAVLLVAPVGLLTGYPAIRRRGLALALVTLAVGVAVSRFVFAQPYATSGLTLGRPAGFTGDRAYYVLELLLLAAAVAAAGALRRGRRGRALAAIRDHESGAAAAGVAVPALKVTAFAAGAALAALGGGMLAMGARAFDPNAFDPVRGLLWFAAVVVLGADSMLGALLASALLVGLDAGTRGGMAAAVIGILAVLLGRFPGGLFEALRTAAVRRLRPPRLTPLGLRVRTSLSGAAPAPAGFAGTAPPDPVSAGPPRARTGGRTNSGSRPPRAADAPAAPAPPARGTAGAGAERPGSAGQARTPGERIPPGPAAGEAPTQAEPAPGRADVPRPRTSEAPQSPHPLRQSTAGREPPGPGNRSLTLRRRRQHGRPPPGRHPAVVSGAPAAGEDVLAARGISVSYGDFTVLSGVDLRVEAGRVTALVGPNGAGKSTLFHTLAGTLRPRAGRVVLRGRDVTRRSAHVRSRLGLARTFQQPAVFSSLTVAENVAVGAEQGPVRDPAAADRVLRLLGLDGPLRDMPATDLPTGTLRRVELGRALAGGPRVLLLDEPAAGLDLGETAALVRLLRALAADGMALLVVEHDLGLVGELADTVYAMAAGRIVASGTAAGVLAAAGAGPVPGRDAPAEAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N167</accession>
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    </protein>
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    </gene>
    <organism evidence="2 3">
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
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            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
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        <source>
            <dbReference type="EMBL" id="AKH81153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="186" mass="17933" checksum="F7631F346710914E" modified="2015-07-22" version="1">MHGPPLAGLLLTALCAGVAGLCLLRMRAVAAEERRGAAGDALMGLGMAAMALPAGLPGPAAWTAGALAAVFGAAFVRAVLPLRAAGHHLHHAIGALAMVYMAVAMGAADHGGHGAAAGLPAVTAGLLAYYVLYVLYGGLRPVAAGAGGPRGPVAAGGGGGWTGRPELAGACRVCMGAGMVAMLLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N1X7</accession>
    <name>A0A0F7N1X7_9ACTN</name>
    <protein>
        <submittedName>
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        </submittedName>
    </protein>
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    </gene>
    <organism evidence="4 5">
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        <lineage>
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        </lineage>
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    <reference evidence="4 5" key="1">
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            <authorList>
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
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        <property type="entry name" value="TAT_signal"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519042" evidence="2">
        <location>
            <begin position="38"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="GP-PDE" evidence="3">
        <location>
            <begin position="56"/>
            <end position="382"/>
        </location>
    </feature>
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            <begin position="32"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH81409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="389" mass="41819" checksum="07C050A2B5F7479E" modified="2015-07-22" version="1">MSDGGTERQQPGRRAVLGAAALGGAAAAVGLPGTARAAGGSGGSGGPGPGGRLPNPAVIAHRGASGYRPEHTLGAYQFALDMGADVIEQDLVPTKDGHLVCRHENEIGGTTDVADHPEFAARKTTKTVDGAQITGWFTEDFTLAELKTLRATERIPAVRQRNTLYNGRWEVPTFEEVLQWAERQRRGTGRPVYLHVETKHPSFFRSIGLELEKPLARLLRRYGRDKSNSPIFLQSFEPSSVERLAGLVDSPGVVLLGAASSRPWDFVQAGDPRTVADLVTPEGLAWIAGFAKGLGPTLDLIIPKDSTGKLLEPTALVRDAHDAGLVLHPYTMRNENTFLPADFRRGTDTTHYGDAFGAFQVYFETGIDGIFTDNPDTGLLARNAFLTRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N1Y9</accession>
    <name>A0A0F7N1Y9_9ACTN</name>
    <protein>
        <recommendedName>
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        </recommendedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="16 17">
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        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>(R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + NAD(+) = (R)-N(6)-lipoyl-L-lysyl-[protein] + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:15045"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="1.8.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11 13">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="11 13">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="13">The active site is a redox-active disulfide bond.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.4" evidence="3 13"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015347.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_06950"/>
    <dbReference type="EnsemblBacteria" id="AKH81996">
        <property type="protein sequence ID" value="AKH81996"/>
        <property type="gene ID" value="AA958_06950"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_06950"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1453"/>
    <dbReference type="OrthoDB" id="267896at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004148">
        <property type="term" value="F:dihydrolipoyl dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006258">
        <property type="entry name" value="Lipoamide_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01350">
        <property type="entry name" value="lipoamide_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 11 13" id="KW-0274">FAD</keyword>
    <keyword evidence="4 13" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 11 13" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9 13" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="15">
        <location>
            <begin position="9"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_dim" evidence="14">
        <location>
            <begin position="341"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="439"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="142"/>
            <end position="144"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="179"/>
            <end position="186"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="12">
        <location>
            <begin position="46"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AKH81996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="462" mass="48657" checksum="3C0561463C86E09C" modified="2015-07-22" version="1">MANDASTVFDLVILGGGSGGYAAALRGAQLGLDVALIEKDKVGGTCLHRGCIPTKALLHAGELADQAREGASFGVNTSLDGIDMAGVHKYKDGVVAGLYKGLQGLIASRKVTVVEGEGRLSSPTSVDVNGQRYTGRHVLLATGSYSKSLPGLEIDGNRIIASEHALVLDRVPKSAIVLGGGVIGVEFASAWKSFGTDVTIIEGLKHLVPAEDENSSKLLERAFRKRGIKFNLGTFFEKAEYTQDGVKVTLADGKEFEAELLLVAVGRGPVSQGLGYEEQGVAMDRGFVLTDAYKRTNVPTISAVGDLTPVLQLAHVGFAEGILTAERLAGLDVVPIDYDGVPRVTYCHPEVASVGITEEKAKETYGADKVVALKYNLGGNGKSKILKTSGEIKLVQVKDGPVVGVHMVGDRMGEQVGEAQLIYNWEALPAEVAQLVHAHPTQNEALGEAHLALAGKPLHAHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2A3</accession>
    <name>A0A0F7N2A3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cystathionine gamma-synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_01115</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH80997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014363.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_01115"/>
    <dbReference type="EnsemblBacteria" id="AKH80997">
        <property type="protein sequence ID" value="AKH80997"/>
        <property type="gene ID" value="AA958_01115"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_01115"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.246"/>
    <dbReference type="OrthoDB" id="637281at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808">
        <property type="entry name" value="PTHR11808"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="376"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH80997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="400" mass="41618" checksum="0A1246C95790702C" modified="2015-07-22" version="1">METPTRSLATEAVHAGREDLAALGLHAAPLDLSTTYPSPDSRGEAARIDEFAATGAPLEGPQVYGRLGNPTVARFEEALARLEGTESAVAFASGMAALSACLLVRAGLGLRHVVAVRPLYGCSDHLLDSGLLGTEVTWTDPAGVADALRPDTGLVLVETPANPTLAETDLRAVAYSCGSVPLLVDNTFATPVLQRPAEHGARLVLHSATKYLGGHGDVMGGVIACDEELAGALRRIRFATGGVLHPLAGYLLLRGLSTLPVRVRAQSATAAELARRLAGHPAVTRVRYPRLGGAMVAFEVRGDPHAVIGAVRLITPAVSLGSVDTLIQHPGSISHRIVDPADRRSGGIGERLLRMSVGLEDVDDLWADLGAALDAAGEPDPAAEAGRAAVSAVRRDPPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2E7</accession>
    <name>A0A0F7N2E7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_11815</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016141.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_11815"/>
    <dbReference type="EnsemblBacteria" id="AKH82805">
        <property type="protein sequence ID" value="AKH82805"/>
        <property type="gene ID" value="AA958_11815"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_11815"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2483"/>
    <dbReference type="OrthoDB" id="913949at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
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        <property type="entry name" value="DUF5753"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="28"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH82805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="281" mass="31498" checksum="AD4047AE4007D043" modified="2015-07-22" version="1">MAGDVTGTSGLGSEPEPSDSMRTFGAVVQALREHAGLSREQLGGHVRYSKHTVASIEGGRRMPPPDFVERAEPVLGDTGVLRRSVPHVVRRPGLARWFRAWAHLETDAISLYTYECRLIPGLLQTEVYARSSFMNQLPPMSDDRIEAQWEARAERQRLLRERTDTAFSFILEEHLFLRQIGGVEVTRDLIGHVLEVAELRNVEIQVMPLVREAHAGLHGPIVLLETPDNHWHAYNEGQESGQLISDSKVVSVLQKRYARMCAQALTPEDSVSLLQRIRGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2G7</accession>
    <name>A0A0F7N2G7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_04500</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014929.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH81574">
        <property type="protein sequence ID" value="AKH81574"/>
        <property type="gene ID" value="AA958_04500"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_04500"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.949"/>
    <dbReference type="OrthoDB" id="1809199at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="272"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="300"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="328"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="353"/>
            <end position="377"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="382"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH81574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="403" mass="39979" checksum="C0F585488E0D0434" modified="2015-07-22" version="1">MASTGEIRRARYAVAAVFAAHGAVTGSFATRVPWVQDHAGISAGQLGLALAMPALGAASAMPLAGRISHTFGARRALRGLMVMWCLALVLPALAPGLATLCAGLFVYGATAGMADVAMNALGVDVEQRLGRSIMSGLHGMWSGGALAGSAAGTVAAHTELDGRVHFALAAAVLTAVSAVACRWVLEPVAHADEEPPPHFALPPRSALLIGAVGFCAVFAEGASLDWSAVYLRDEMGSSPGLAAACTTGFALTMAVARLVGDAVVERLGPVRTVRAGGMLATLGGVLIVTSSAAAQAMAGFGLLGLGIAVVVPVVFAAAARSAHAPSQAIAGVATIMYASGLIAPAAIGQVADATSLTVSFGLVTVLATGLIAGAGLLRGQRSKTRAKAPGAVPDPAPAPGTDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N357</accession>
    <name>A0A0F7N357_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Amino acid ABC transporter ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_05945</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015172.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_05945"/>
    <dbReference type="EnsemblBacteria" id="AKH81819">
        <property type="protein sequence ID" value="AKH81819"/>
        <property type="gene ID" value="AA958_05945"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_05945"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1243"/>
    <dbReference type="OrthoDB" id="1475841at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015658">
        <property type="term" value="F:branched-chain amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030660">
        <property type="entry name" value="ABC_branched_ATPase_LivF/BraG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039137">
        <property type="entry name" value="ABC_branched_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH81819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="238" mass="25527" checksum="9C10FBFA73B8FB47" modified="2015-07-22" version="1">MTALLQVEDLKVAYGKIEAVKGISFSVQSGEVVTLIGTNGAGKTTTLRTLSGLLKPAGGKIFFDGTPLNGVGAHKIVAMGLAHSPEGRRLFPRLTITENLQLGAFLRKDAAGIEQDIQMCYELFPILGERRKQAAGTLSGGEQQMLAMGRALMSRPKLLMLDEPSMGLSPIMMQKIMETIRELKAQGTTILLVEQNAQAALSIADHGHVMEVGKVVLSGTGEELLHDESVRKAYLGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3H2</accession>
    <name>A0A0F7N3H2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 10">Histidinol dehydrogenase</fullName>
            <shortName evidence="10">HDH</shortName>
            <ecNumber evidence="5 10">1.1.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">hisD</name>
        <name evidence="17" type="ORF">AA958_06395</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 10">Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>H2O + L-histidinol + 2 NAD(+) = 3 H(+) + L-histidine + 2 NADH</text>
            <dbReference type="Rhea" id="RHEA:20641"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:57699"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 15">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10 15">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 10 11 16">Belongs to the histidinol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.23" evidence="5 10"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015251.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_06395"/>
    <dbReference type="EnsemblBacteria" id="AKH81898">
        <property type="protein sequence ID" value="AKH81898"/>
        <property type="gene ID" value="AA958_06395"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_06395"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1335"/>
    <dbReference type="OrthoDB" id="935289at2"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00014"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004399">
        <property type="term" value="F:histidinol dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06572">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01024">
        <property type="entry name" value="HisD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
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        <property type="entry name" value="Histidinol_DH_CS"/>
    </dbReference>
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        <property type="entry name" value="Histidinol_DH_monofunct"/>
    </dbReference>
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        <property type="entry name" value="Hstdl_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21256">
        <property type="entry name" value="PTHR21256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00815">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000099">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00083">
        <property type="entry name" value="HOLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00069">
        <property type="entry name" value="hisD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00611">
        <property type="entry name" value="HISOL_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="7 10 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13" id="KW-0520">NAD</keyword>
    <keyword evidence="9 10 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10 15" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton acceptor" evidence="10 12">
        <location>
            <position position="339"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10 12">
        <location>
            <position position="340"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 14">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 14 15">
        <location>
            <position position="270"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10 14 15">
        <location>
            <position position="273"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10 14">
        <location>
            <position position="340"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 14 15">
        <location>
            <position position="373"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10 14">
        <location>
            <position position="427"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 14 15">
        <location>
            <position position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003850"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR000099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU004175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AKH81898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="456" mass="47254" checksum="D7EB14D8A1F8101C" modified="2015-07-22" version="1">MISRIDLRGSAAASDAGGGIDRDLLPRAELDVEAALEKVRPLCEDVRHRGTAAVIEITERFDGVTLERLRVPAEALRRALAELDPEVRAALEESIRRARIVHREQRRADTAVRVVPGGTVTERWLPVARVGLYVPGGQAVYPSSVVMNVVPAQEAGVPSLAVSSPPQKDVPNSWGAGLPHPTILAACALLGVDEVYAAGGAQAVAMFAYGTDECAPVDMVTGPGNVYVAAAKRLLKGRIGIDAEAGPTEIAVLADDTADPAHVAADLVSQAEHDELAAAVLVTPSERLAEAVEAELKTQVAATRHGERITAALGGRQSGIVLVDDLEAGLRVVDAYAAEHLEIQTADAAAVAARVRNAGAIFVGAYAPVSLGDYCAGSNHVLPTGGCACHSSGLSVQSFLKGIHVVDYTRDALAEVTAHVVNLAEAEDLPAHGAALKARFAGGEPGGHSGGKVPQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3K7</accession>
    <name>A0A0F7N3K7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_06800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH81969">
        <property type="protein sequence ID" value="AKH81969"/>
        <property type="gene ID" value="AA958_06800"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_06800"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1422"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519133" evidence="2">
        <location>
            <begin position="27"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH81969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="111" mass="10956" checksum="7BE9F4DE9106E62A" modified="2015-07-22" version="1">MAFSKRMAALTAVVAIPLGIAATSYALTDDPEDPAPPARVEMEGGTSSPPGSASPSTGTSPGEETGKETVSPPPVRDGPTTDPSGSASGDDDADDTGDDSGGGNDDDEFDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3P4</accession>
    <name>A0A0F7N3P4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase</fullName>
            <ecNumber evidence="4">2.4.2.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">N(1)-alpha-phosphoribosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AA958_06935</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5,6-dimethylbenzimidazole + nicotinate beta-D-ribonucleotide = alpha-ribazole 5'-phosphate + H(+) + nicotinate</text>
            <dbReference type="Rhea" id="RHEA:11196"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15890"/>
            <dbReference type="ChEBI" id="CHEBI:32544"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:57918"/>
            <dbReference type="EC" id="2.4.2.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nucleoside biosynthesis; alpha-ribazole biosynthesis; alpha-ribazole from 5,6-dimethylbenzimidazole: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CobT family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.21" evidence="4"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015345.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_06935"/>
    <dbReference type="EnsemblBacteria" id="AKH81994">
        <property type="protein sequence ID" value="AKH81994"/>
        <property type="gene ID" value="AA958_06935"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_06935"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1449"/>
    <dbReference type="OrthoDB" id="1765140at2"/>
    <dbReference type="UniPathway" id="UPA00061">
        <property type="reaction ID" value="UER00516"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008939">
        <property type="term" value="F:nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02439">
        <property type="entry name" value="DMB-PRT_CobT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1610.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003200">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023195">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036087">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02277">
        <property type="entry name" value="DBI_PRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52733">
        <property type="entry name" value="SSF52733"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AKH81994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="363" mass="37463" checksum="1DEF2BF8D8B082DF" modified="2015-07-22" version="1">MSGLNLDDFINDIDRPDSAVRRDAEEWRATHGPRPGALGRLDDLGEWLTAAQGGVPAKPVAAPRLVLFAGDHGVAELDVSGRAAGTADALARAALDGRSASAILARRFGAGLRVVDMALDCDPESLPKEVTRHRVRRGSGRIDVEDALTAEEAEEAFRAGMAVADEEADSGTDLLLLGDLSVGGTTAAGAIVAALCGTDASVVTGRGGAGIDDLAWMRKCAAIRDALRRARPVLGDQLQLLATVGGADLTAMTGFLLQAAVRRTPVVLDGVVSAAAALVAQRVAFRAPDWWLAGQASGEPAQEKALDRIAIDPLLDHGVTTGEGAGALLALPFLQAAAELWADLPENTPGKDAAAEEAVDDIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3R0</accession>
    <name>A0A0F7N3R0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Malate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_10960</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="3">Divalent metal cations. Prefers magnesium or manganese.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the malic enzymes family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015999.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_10960"/>
    <dbReference type="EnsemblBacteria" id="AKH82661">
        <property type="protein sequence ID" value="AKH82661"/>
        <property type="gene ID" value="AA958_10960"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_10960"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2306"/>
    <dbReference type="OrthoDB" id="654531at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
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        <property type="term" value="F:metal ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Malic_N_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Malic_NAD-bd"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00072">
        <property type="entry name" value="MALOXRDTASE"/>
    </dbReference>
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        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT" evidence="5">
        <location>
            <begin position="12"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH82661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="477" mass="49533" checksum="15367036B7B48BFA" modified="2015-07-22" version="1">MATAPSVSYSNTVRLEVPAGGNAVSQLTSAVESSGGSVTGLDVTASGHERLRIDVTIAAASTDHARSIVEKLRGIEGVVVGKVSDRTFLMHLGGKIEMQSKHPIRNRDDLSMIYTPGVARVCMQIAENPEDARRLTIKRNSVAVVTDGSAVLGLGNIGPKAALPVMEGKAALFKRFASIDAWPLCLDTQDTDAIVEIVKAIAPGFAGINLEDISAPRCFEIEARLREALDIPVFHDDQHGTAIVVLAALTNALRVVGKELADVRVVMSGAGAAGTAILKLLIDAGAKHAVVADINGVVHSGRADLVDAPPGSALRWIAENTNRDGLTGTLKDAVRGADVFIGVSAPDVIDGGDVAAMASDAIVFALANPDPEVDPAAAREHAAVVATGRSDFPNQINNVLVFPGVFRGLLDAHSRTVNSEMMIAAARAIADVVHGDELNPNYIIPSVFNDRVAPTVADAVRDAAQAAGVTAPPTTGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3Y2</accession>
    <name>A0A0F7N3Y2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA ligase (ATP)</fullName>
            <ecNumber evidence="1">6.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_07435</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_LIGASE_A3" evidence="3">
        <location>
            <begin position="119"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH82089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="334" mass="36200" checksum="89A39589EF36A612" modified="2015-07-22" version="1">MTDPGGLPHVPPMLAVSGSLPTAAADPSWAYELKWDGIRAVAYAPGDGSLTLRTRNDNDVTVRYPELAPLGEALAAAGHACVLDGEIVALGADGRPSFGALQRRMNLTRGAVIARLATEVPVDYMAFDVLYLDGESTLRLPYRARRALLTDLRVEGPHWRTPPHWEGHGTEAWEMTRRYGLEGLLAKRLESPYLPGRRSGLWLKIKNVRTQEVVVGGWTEGAGSRSDAVGGLLMGVWTEAGELAYAGTVGSGFSRHALEVLRERLAGLARDTSPFSGPVADRHVRAGGAVHWVEPELVGEVTYGEWTATGVLRHPVWRGLRPDKGPEEARRPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3Z4</accession>
    <name>A0A0F7N3Z4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_07480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015448.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_07480"/>
    <dbReference type="EnsemblBacteria" id="AKH82098">
        <property type="protein sequence ID" value="AKH82098"/>
        <property type="gene ID" value="AA958_07480"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_07480"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1568"/>
    <dbReference type="OrthoDB" id="1465613at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="22"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="395" mass="41853" checksum="524F6A7C484FA3A5" modified="2015-07-22" version="1">MTEQTSGTEPPFRTVPDDGEPLRILVVGAGRMARLWLRTILASPETMLVGVVDTAPAAAEKALAETGAPDVPTGPDLTAVAAATSPDAVVDVTVPAAHLPVTLEALALGLPVLGEKPLAVTLPEALRLAAAAELAGELFMVSQSRRYHPHLFAFKQQAGRLGRLGILTTEFFRAPRFGGFRDTMDHPLLLDMAIHPFDTARWLLDAEPVSVRCEEYNPGWSWYAGAAATTAVFEMTGNSRYVFTGSWCSPGLETSWNGAWRLSGEHGSITWNGGRPTAVEMTPEPGVDRAAGRAQTTAEPMKGVAGSLAAFVHALRTGTVPMGEVHDNVMSLAMVTGALESALTDRRIRVDDLLDAALADALVSATGPERDLLCSRPRRLLRGPARGPLASGPAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N460</accession>
    <name>A0A0F7N460_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_04845</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014987.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_04845"/>
    <dbReference type="EnsemblBacteria" id="AKH81632">
        <property type="protein sequence ID" value="AKH81632"/>
        <property type="gene ID" value="AA958_04845"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_04845"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1020"/>
    <dbReference type="OrthoDB" id="635734at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="4">
        <location>
            <begin position="13"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="3">
        <location>
            <begin position="199"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH81632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="407" mass="44402" checksum="943FD15F39CB29BF" modified="2015-07-22" version="1">MRISFLISNAYAVGGTVRTTFTLARALAEQHDVEIVSVFRHKDEPVFDAGPHVPVRALVDERPDSPCYAGGHPDYARSARHYPRADGRYHQYSALTDRLLAGHLRHLDADAVIGTRPGLNVVVARHTRRGVLRVGQEHLTFTTHPRELRVALSAAYPRLHAVVTMTEADARAYREHLRLPGVVVTAIPNGVPAPAVAPSDNTARCVMAAGRLAPLKHFNHLVKAFARVVRARPDWQLRIYGDGPRHDALRAQIDRLGLYNHVLLMGTVHPLEPEWPKSSIAAHTSTLESFGLTIAEAMRGGLPVVAADCPLGPREIIEDGEDGLLVPPGEPAAVARGLLRLIGDEDLRQEMGTAALANAARFDPARAAERYDGLFARLHVHRPTLPLTGTVLGGLYARRTREEAVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4H0</accession>
    <name>A0A0F7N4H0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Beta-galactosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_12275</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016216.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_12275"/>
    <dbReference type="EnsemblBacteria" id="AKH82881">
        <property type="protein sequence ID" value="AKH82881"/>
        <property type="gene ID" value="AA958_12275"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_12275"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2581"/>
    <dbReference type="OrthoDB" id="1832114at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006103">
        <property type="entry name" value="Glyco_hydro_2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Glyco_hydro_2_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006104">
        <property type="entry name" value="Glyco_hydro_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02836">
        <property type="entry name" value="Glyco_hydro_2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02837">
        <property type="entry name" value="Glyco_hydro_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="SSF49303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_2_N" evidence="7">
        <location>
            <begin position="31"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_2" evidence="5">
        <location>
            <begin position="190"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_2_C" evidence="6">
        <location>
            <begin position="293"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH82881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="613" mass="67879" checksum="9339A74CC3A8CC23" modified="2015-07-22" version="1">MPDSHAPSAPAGTPRPEYPRPGFVRADWLNLNGTWQFARDPGDSGFERGLAHSELPERIVVPFCPESELSGIGDTDFHHAVWYRRTVRIPEAWAGRRVLLHFGAVDHDATVWVNGREVARHSGGFTPFSADLGGAVRAGEEAVVVVRARDAARGPQARGKQSTAYDNHACFYTRTTGIWQTVWLEPVADTHFRRPRITPDLAAGCFHVEVPLAGSRTGHRVRAELRDGHGVVTEAAVAADFDLAPRLVLPVPDERRRPWSPEDPHLYELALELTGPDGTVIDRAVCTAGLRAVTVDGKRILINGKPVFQRLVLDQGYYPDGLMTAPDDAALVRDIELSLAAGFNGARLHQKVFEERFLHHADRLGYLVWGEFGDWGASTGGPVGPDNQQPTAGFVAQWLEAVERDYSHPALIGWCPLNETRQVLTDRQSVLDDVTRAMFLATKAADTSRPVLDASGYAHRVPETDVYDSHCYEQDPQAFGELMAGLRAGTPFVNPQDEAAGQTWSLPYGGQPYFCSEFGGIWWNPEDAASAGEDRLVSWGYGQRPRDEEAFHERFAGLTGVLLGDPDMFGYCYTQLTDVFQEQNGIYRFDRSEKLDVRRVREAQLRPAAFEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4L2</accession>
    <name>A0A0F7N4L2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peroxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_12605</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DyP-type peroxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016266.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_12605"/>
    <dbReference type="EnsemblBacteria" id="AKH82931">
        <property type="protein sequence ID" value="AKH82931"/>
        <property type="gene ID" value="AA958_12605"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_12605"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2648"/>
    <dbReference type="OrthoDB" id="837319at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006314">
        <property type="entry name" value="Dyp_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04261">
        <property type="entry name" value="Dyp_perox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01413">
        <property type="entry name" value="Dyp_perox_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51404">
        <property type="entry name" value="DYP_PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 5" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="33"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH82931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="385" mass="39970" checksum="0FB1B2FADA281632" modified="2015-07-22" version="1">MDRVDHPPSRRAFLDVTGAAVAAGLVAGCSGDTAEPARSAPSAATGPAPVPATGRHQAGITSPRSAQRNLLAVVADLGAAVPPGPLLAELGETIRTLTAGSDPRLLGLPPGDLTVTVGVGPRLVRTAGASLPGAVDLPRFSRERIAPQARGGDLLMQICADDALLLPAVAAALLDQAGDRLRERWRQSGRRGTDVPVAKGRTAPRNLLGFIDGIVGPHTKAEQERDLWLAGPPAVAGGTLAVLRRMELALTRFAALSVAQQEAVFGRRRASGAPLSGGTVAAAPELGAKTPDGRYLVPVDAHVRRANPTAAGVGHMLRRSYSTDEPAPGLLFISFQNDLRTFTATLTRMETSDALLPFTATTAGATFLILPGFDRQHPLGSTLFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4W6</accession>
    <name>A0A0F7N4W6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dihydroxy-acid dehydratase</fullName>
            <ecNumber evidence="3">4.2.1.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_17475</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IlvD/Edd family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.9" evidence="3"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017004.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_17475"/>
    <dbReference type="EnsemblBacteria" id="AKH83700">
        <property type="protein sequence ID" value="AKH83700"/>
        <property type="gene ID" value="AA958_17475"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_17475"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3675"/>
    <dbReference type="OrthoDB" id="193579at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004160">
        <property type="term" value="F:dihydroxy-acid dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044238">
        <property type="term" value="P:primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042096">
        <property type="entry name" value="Dihydro-acid_dehy_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000581">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020558">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037237">
        <property type="entry name" value="IlvD/EDD_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00920">
        <property type="entry name" value="ILVD_EDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143975">
        <property type="entry name" value="SSF143975"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00886">
        <property type="entry name" value="ILVD_EDD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH83700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="583" mass="62150" checksum="A6DE73EBEE2D8932" modified="2015-07-22" version="1">MTDASVGSKARSDRRSQAWFGAAGRGGMIYRSWMRNQGFGHEVFDGRPVIGIAVSASELAPCNAHLDRVAEAVKRGVWQAGGLPLAFPTMATGETLMRPTAMLFRNLMAMEVEELIRANPLDGVVLLSGCDKTTPAMLMGAASVDLPAVMVTGGPMLNGKYRGRDVGSGTAVWQFEEELKTGRMTQEECFFAEGCMARSNGHCMTMGTASTMACMAESLGMQLPGSATWPAVDARRFEIAQSAGKRIVEMVDEDLRPSKVMTREAFENAIRTNAAIGGSTNAIIHLAAIAGRLGVELSVDDFDRLTREVPTLVNLQPSGAYLMEDFCYAGGLPAVHRELVTGGLLHAQQITVTGRSIAANTEGAERVGDDVITPLATPFLDAGTGTAVLRGNLAPNGAVLKQSAATPELLQHRGRALVFDSPEAYHEVCDDPELDVTADDILVIRGAGPRGYPGMPEVSNVPLPTKLLKAGVTDMVRICDGRMSGTGYGTVVLHVAPEAAVGGPLALVRTGDEIELDVAGRRLSLEVSDEELAERRAAWTAPEPRHTSGYAWLYTEFVTQADEGADLTFLRGSRGHAIPRDSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N534</accession>
    <name>A0A0F7N534_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cell division protein FtsQ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ftsQ</name>
        <name evidence="10" type="ORF">AA958_06525</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Essential cell division protein.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <text evidence="7">Localizes to the division septum.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the FtsQ/DivIB family. FtsQ subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015274.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_06525"/>
    <dbReference type="EnsemblBacteria" id="AKH81922">
        <property type="protein sequence ID" value="AKH81922"/>
        <property type="gene ID" value="AA958_06525"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_06525"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1362"/>
    <dbReference type="OrthoDB" id="1270665at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090529">
        <property type="term" value="P:cell septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043093">
        <property type="term" value="P:FtsZ-dependent cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00911">
        <property type="entry name" value="FtsQ_subfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005548">
        <property type="entry name" value="Cell_div_FtsQ/DivIB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026579">
        <property type="entry name" value="FtsQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034746">
        <property type="entry name" value="POTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013685">
        <property type="entry name" value="POTRA_FtsQ_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03799">
        <property type="entry name" value="FtsQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08478">
        <property type="entry name" value="POTRA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51779">
        <property type="entry name" value="POTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 7 10" id="KW-0132">Cell division</keyword>
    <keyword evidence="1 7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="POTRA" evidence="9">
        <location>
            <begin position="70"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AKH81922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="273" mass="29172" checksum="2081DF7549C87CD7" modified="2015-07-22" version="1">MAGAVREKAAAGREERGGGAGPSGPPAARWPAGGRGRLRPPRRRVVVAVLLAVIVLGGFAVWALYGSNWLRVERVTVSGTDVLSADEVLDAARVSEDVPMATVDTDAVEARLAAELPRIGTVDVDRVWPHRIAVQVTERQPAVLLRKGESFVEVDDEGVRFATVRTAPENVPIVEMQVADSPSLDRFGRQRLRESAVRVAGALSESVRRDTRTILVRSYDSVTLELSGGRTVLWGSAERGAAKSKALAAVMKAERDARYFDVSVPSAPAASSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N535</accession>
    <name>A0A0F7N535_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_09890</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015836.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_09890"/>
    <dbReference type="EnsemblBacteria" id="AKH82494">
        <property type="protein sequence ID" value="AKH82494"/>
        <property type="gene ID" value="AA958_09890"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_09890"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2082"/>
    <dbReference type="OrthoDB" id="1835483at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="190"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH82494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="452" mass="44964" checksum="A8597C46CEE8FCB6" modified="2015-07-22" version="1">MANTPPVSQLNSCPSCEEPLEEGDLFCGACGADLAAPAPAPAAAAPAAGPNGAAPAAAPAGAPPAGQVAAPDSRPSDGQRTGSYRIAGPGTAPQGGGDSGEFLLDTPTEDPEHYPIAEPVAPQGADPRAALGTAAPDAPAAAETPAAGQVPPGRRCIACRTGTIDADGYCERCGHAQPRERDHMEHEVEGVAAVSDRGLRHHRNEDFFAIAGTALPNGAPATVAVVCDGVSSAGRPDEASAAASVAAGASLQATLGRGLHPQQAMHEALLAAAGSVNELAAQHSPLSHQNAPACTIVSAVIAGGILTVGWVGDSRAYWVPDDRAAPSARLTEDDSWAAQMVAAGLMSEADAYADERAHAITGWLGADAHELDPHTASFKPDGPGVVIVCTDGLWNYAEAAAELAAAVPQDAATRPLHAAQVLVGHALDGGGHDNVTVAVLPFPGPAGGAGPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N548</accession>
    <name>A0A0F7N548_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_06615</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015289.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_06615"/>
    <dbReference type="EnsemblBacteria" id="AKH81937">
        <property type="protein sequence ID" value="AKH81937"/>
        <property type="gene ID" value="AA958_06615"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_06615"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1380"/>
    <dbReference type="OrthoDB" id="1635662at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH81937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="377" mass="39858" checksum="6AA68CC98BFD94F5" modified="2015-07-22" version="1">MGDLAWLALYAMFGLVALWLLWEVLMQYKAPLRWRALAFVGFLCVVLGVLMPSVVVIGLGVVVFALGQAKVTLSYRSGYSGGWAVNRRGEDEDYGGGYEAQGYDAQGYDDGPYDGRQAPPPPEHAAPYPAYEPEGAPVAAQEQTSQFSPFGDEQALAGAAPGQQTYAGGYDAYGNGSSGAGYDSGSYATTSAYDSGGYATTSAYDTGSHATASAYDTGSHATTSGYEAGGYATNGAGMDGYGQDQQIYPDTGGYGTEHPYAGYDTAAPAPGGYPDPYGGTEYAAPAPPQYYDSTQGGGQQYDTGGAGYPGYDQQQYGQQYAEGYDTGRQPAYGQENYGTAGDSVWMPQQRDADPLGTEDPYAQQQGYPGYEQQQYRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N587</accession>
    <name>A0A0F7N587_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase</fullName>
            <ecNumber evidence="2">2.7.6.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AA958_18115</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 4/4.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.3" evidence="2"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017105.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_18115"/>
    <dbReference type="EnsemblBacteria" id="AKH83805">
        <property type="protein sequence ID" value="AKH83805"/>
        <property type="gene ID" value="AA958_18115"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_18115"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3809"/>
    <dbReference type="OrthoDB" id="1953248at2"/>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003848">
        <property type="term" value="F:2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00483">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000550">
        <property type="entry name" value="Hppk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035907">
        <property type="entry name" value="Hppk_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01288">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55083">
        <property type="entry name" value="SSF55083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01498">
        <property type="entry name" value="folK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HPPK" evidence="8">
        <location>
            <begin position="33"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH83805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="197" mass="21360" checksum="2E2756377FA49657" modified="2015-07-22" version="1">MNRSDPTVQPVPHSVVEQVDAADSTLQNPKLAVLSIGSNLGNRLETLQGSVDALEDTPGLRVKAVSPVYETDPWGVEPGSQPTFFNAVLIVRTSLPPASLMERAHAVEEAFARVRDEQWGPRTLDVDIVAYQGVVSDDPALTLPHPRAHERAFVLVPWHDVDPAAELPGRGPVAELLAQIGPQGVRPRTDLELRLPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5E8</accession>
    <name>A0A0F7N5E8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FBP_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_10810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015974.1">
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH82634">
        <property type="protein sequence ID" value="AKH82634"/>
        <property type="gene ID" value="AA958_10810"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_10810"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2274"/>
    <dbReference type="OrthoDB" id="1684141at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032330">
        <property type="entry name" value="EF-G-binding_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16571">
        <property type="entry name" value="FBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FBP_C" evidence="1">
        <location>
            <begin position="8"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="170" mass="18300" checksum="9ED74DAC68B5872D" modified="2015-07-22" version="1">MEPLSEKEIRASFVNATKGDAGRLKLPLDFAGLPWPDLDFLGWVDPGAPLRAHLVVPRPDGPLGITLRVPAAGRASAVRSRMCQLCLTAHSASGVRLLAAPLAGPRGRQGNTVGVYVCADLACSLYLRGKRQPKLRTVPQEESLTEAERIARMWGNLEDFVRKVTAPAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5H7</accession>
    <name>A0A0F7N5H7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_15115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_037737371.1">
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH83326">
        <property type="protein sequence ID" value="AKH83326"/>
        <property type="gene ID" value="AA958_15115"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_15115"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3185"/>
    <dbReference type="Proteomes" id="UP000034283">
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    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008556">
        <property type="term" value="F:P-type potassium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043462">
        <property type="term" value="P:regulation of ATP-dependent activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011726">
        <property type="entry name" value="KdpF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09604">
        <property type="entry name" value="Potass_KdpF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02115">
        <property type="entry name" value="potass_kdpF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="29" mass="3135" checksum="23CF289CD83E8B8E" modified="2015-07-22" version="1">MTTDNVVGLIVAVALLGYLVLALVFPERF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5V7</accession>
    <name>A0A0F7N5V7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NADH dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_11685</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NADH dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_11685"/>
    <dbReference type="EnsemblBacteria" id="AKH82784">
        <property type="protein sequence ID" value="AKH82784"/>
        <property type="gene ID" value="AA958_11685"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_11685"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2457"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006116">
        <property type="term" value="P:NADH oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045024">
        <property type="entry name" value="NDH-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706">
        <property type="entry name" value="PTHR43706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="3">
        <location>
            <begin position="5"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="421"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="426"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="449"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH82784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="470" mass="51116" checksum="C29ECD79B7B988EB" modified="2015-07-22" version="1">MRYGEASVTVVDPRSYMTYQPFLPEAAAGSISPRHVVVPLRQVLPGAEVLTGRVTSIDQDRKVAVVAPIVGTPYEVPFDYLIVALGAVSRTFPIPGLAENGIGMKGVEEAIGLRNHVLEQLDKAESTNDADTRRKALTFVFVGGGFAGAETIGEIEDLARDAATYYPSIKREDMRFVLVDAADKILPEVGPALGKWGLKHLQERGIEVYLDTSLESCVDGRVVLKNGLEVDSNTLVWTAGVKPHPVLKEYGLPLGPKGHVDTAATLQVQGTDYIWAAGDNAQIPDLAARAAGAENAWCPPSAQHALRQAKLLGDNVVAELRGFPQRQYRHKNKGAVAGLGLHKGVAMINVLGRSLKFKGRLAWYMHRGYHGLAVPTWNRKIRVFMDWTLGVFLKREVVSLGAMESPRDEFYEAAAPVTAAARAQHDQSVREAEATREKEQARGAVGLPPAEDGRDERGREEHSREAARAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-10-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6L0</accession>
    <name>A0A0F7N6L0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_21110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH84275">
        <property type="protein sequence ID" value="AKH84275"/>
        <property type="gene ID" value="AA958_21110"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_21110"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4445"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="213" mass="24320" checksum="0BC77987987207FA" modified="2015-07-22" version="1">MEVSLRVTKGDHGAVDDREIISYFDGRATFDITISNGRAWDVPKIIDMAYEFGYTFRFVYYGPGIQRLVFERDDGEHGRSRAWWSVAHYRQYGVWGRPQPRVSLPVHMGPRIDPLEAAKARYALGMLRNKAWGLRVSAILAALIAIAVWSFHDRVEVIIPILLVGVPFVLVGALTPWLPSKRLRRHQQTVETFELQQAVERGFIPPPSPHNED</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6M2</accession>
    <name>A0A0F7N6M2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP-dependent Clp protease ATP-binding subunit ClpX</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">clpX</name>
        <name evidence="10" type="ORF">AA958_09645</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the ClpX chaperone family.</text>
    </comment>
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        <property type="protein sequence ID" value="AKH82447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AKH82447">
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        <property type="gene ID" value="AA958_09645"/>
    </dbReference>
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    <dbReference type="PATRIC" id="fig|444103.5.peg.2032"/>
    <dbReference type="OrthoDB" id="718259at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:protein dimerization activity"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ClpX_bact"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF07724">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06689">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00994">
        <property type="entry name" value="zf-C4_ClpX"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF52540"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="CLPX_ZB"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ClpX-type ZB" evidence="9">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="410"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="124"/>
            <end position="131"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="AKH82447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="430" mass="47056" checksum="D7AFAA3515A5FDC1" modified="2015-07-22" version="1">MARIGDGGDLLKCSFCGKSQKQVKKLIAGPGVYICDECIDLCNEIIEEELAESSEVRWEELPKPREIYEFLEGYVVGQEAAKKALSVAVYNHYKRVQAGENGAAAQNREDGIELSKSNILLLGPTGSGKTLLAQTLARMLNVPFAIADATALTEAGYVGEDVENILLKLIQAADYDVKKAETGIIYIDEIDKVARKSENPSITRDVSGEGVQQALLKILEGTTASVPPQGGRKHPHQEFIQIDTTNVLFIVGGAFAGLEKLIESRAGAKGIGFGATIRSKRELANEDPFQEVMPEDLVKYGMIPEFIGRLPVITSVHNLDRAALLKILVEPRNALVKQYQRLFELDGVELDFDRPALEAIADQAILRGTGARGLRAIMEEVLQSVMYEVPSRKDVARVVITEEAVHSNVNPTLVPRSRAAEPEQRHQESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6W5</accession>
    <name>A0A0F7N6W5_9ACTN</name>
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        <submittedName>
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        </submittedName>
    </protein>
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        <name evidence="7" type="ORF">AA958_10385</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
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            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
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    </dbReference>
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        </source>
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        </source>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
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        </source>
    </evidence>
    <sequence length="421" mass="43015" checksum="FAC73AE38AFD6846" modified="2015-07-22" version="1">MGAAGVLESDRLRTGRDAGRRNTAVLVAFTAVTNLADGVLKMALPLLAVRAGGSPAQVTGVALAISLPWLLVALHAGVLVDRVDRRRLLWIVNVLRLLAMVPLLAAAASGDLSVALLAAAGAAIGVADVVASTAATALVPAAVPPAGRDKANAWVAGAETVFSEFAGPFVGGLLIAVGAGWALGATWAAYAAAALVLLLLAGRFRAGAVAYENGDEAPATTVNGQIAEGLRYLWRHRLLRSLSLILTVLSGTWGAWLALIPLYATRDMGLTPGQYGVLLSALGIGGLLGATTVTWLNRLLGRRRVMLADLFGTAAMAAVPALTADARAVAAAAFLGGLGGTLWTVNSRTVVQRAVPDAMLGRFSSASRMFAWGAMPLGAGLVGLLAEFAGPRAAFGFFAVASLLTVPFFLRAAARGADTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-10-07" version="25" xmlns="http://uniprot.org/uniprot">
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    </protein>
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    </gene>
    <organism evidence="5 6">
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        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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    </dbReference>
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    </dbReference>
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        <property type="gene ID" value="AA958_21905"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_21905"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="DeoR_HTH"/>
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        <property type="entry name" value="HTH_11"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026881">
        <property type="entry name" value="WYL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08279">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13280">
        <property type="entry name" value="WYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016838">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF46785"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="4">
        <location>
            <begin position="5"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH84405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="331" mass="36184" checksum="DB195D86B72A8226" modified="2015-07-22" version="1">MTTDTPKRLLHLLSLLQTPREWPGSELAGRLGVTDRTIRRDIERLRDLGYPVESTRGTAGGYRLVAGKAMPPLLLEDDEAVAIAVGLRSSAGHTVAGLAEASVRALAKLEQVLPSRLRRRVTSLGTATTPLTRWQGPQVDAEVLTVLAAGAAGGERLRFGYRAADGTETKRLVEPAGLVAAGRRWYFVAYDNDRDDWRMFRVDRITRPFATGVRPPRRELPAADAAAFVEDRMGGDRPRYRARATLHAPYKELARRLAGTEGLTRLDEGRCAFVTEADGLDWLALRLTALGCEFEVHEPRELAEYLRDLAGRASRAAGAMGEGTGEGTGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7Q4</accession>
    <name>A0A0F7N7Q4_9ACTN</name>
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        <submittedName>
            <fullName evidence="2">Acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_23225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_23225"/>
    <dbReference type="EnsemblBacteria" id="AKH84630">
        <property type="protein sequence ID" value="AKH84630"/>
        <property type="gene ID" value="AA958_23225"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_23225"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4896"/>
    <dbReference type="OrthoDB" id="1389691at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="203"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="337" mass="35552" checksum="264CA4E2AA6401A9" modified="2015-07-22" version="1">MEFTTGARLEIRITPADVGKRVSVRRLTDACEGDARFTDAVGVLTSWDAGELRLTRRNGEVVRIPEAAVVAAKAVPAAPARRRGPAATAAELTRVAARGWPPVESERLGDWTLRASAGFTSRANSVLPLGDPGLPLDAALARVTRWYGERGLPALVQVATGAAGTAEPLAAELDARGWTVRRSALMQVGELAPVADRGEAGRVELSRTTSAAWFSLYNRAAELTPAARTVLEGGPSVWFATVRDPSGADPSGTPAAIGRCVVDGRWAGFAAVEVAPAHRRRGLATAVMAALATRALEEGASAAYLQVEPDNTAALALYNALGFTTHHSYHYRHHPTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8I2</accession>
    <name>A0A0F7N8I2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">XRE family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_24430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018087.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_24430"/>
    <dbReference type="EnsemblBacteria" id="AKH84835">
        <property type="protein sequence ID" value="AKH84835"/>
        <property type="gene ID" value="AA958_24430"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_24430"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5148"/>
    <dbReference type="OrthoDB" id="824224at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="30"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="297" mass="32716" checksum="91AD87338AFAF41E" modified="2015-07-22" version="1">MARAGGEAGATALSGPSAPTAGQLVLGRRLQNLRESAGFTPEQAAKALRVNATSVRRMEKAEVGLKYASVEKLLRTYGLPQDDIESFLDLVEEANKPGWWHRFRDVLPEQFGLYVSLESAATLIRAYEPHCVPGLLQTEDYARALLSAGHLPLAAGERERRVTLRMERQGLLIRQPKPLRLWAIVDEAALRRTVGGPQTMRAQLDRLVEVSRMPNVTLQVLPFDTGPHPAMYGPLHLLRFPAPELGDFGYSESLTGPAYVEDTALVSQCLEALNRISTQAPPAHQTENIIANIRKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8J5</accession>
    <name>A0A0F7N8J5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_17835</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017061.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_17835"/>
    <dbReference type="EnsemblBacteria" id="AKH83759">
        <property type="protein sequence ID" value="AKH83759"/>
        <property type="gene ID" value="AA958_17835"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_17835"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3757"/>
    <dbReference type="OrthoDB" id="2089619at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041678">
        <property type="entry name" value="TetR_C_16"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17920">
        <property type="entry name" value="TetR_C_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="26"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH83759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="227" mass="24610" checksum="E8D184B828470299" modified="2015-07-22" version="1">MTPENAADPPKRGRGRPRRGAAEDGPGTRDRILAKARSEFAARGFEKTSIRGIAKSAGVDPALVHHYFGTKERVFEAALEITFAPAMAIPDIVVDGPAEDAGERMTRFFFGVWENRLSREPLLAVIRSAVSNETAAAIFRKIVTRNLLRRITPSLPQPDAEMRAELAVAQLVGTAMLRYIVRLEPMASAAPEELIRRLSPIVQYHLMDGPPSPPAPSPPAPPPPPGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8K0</accession>
    <name>A0A0F7N8K0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_17890</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017071.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_17890"/>
    <dbReference type="EnsemblBacteria" id="AKH83769">
        <property type="protein sequence ID" value="AKH83769"/>
        <property type="gene ID" value="AA958_17890"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_17890"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3768"/>
    <dbReference type="OrthoDB" id="1437290at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="7"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH83769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="199" mass="21369" checksum="675155BC07838008" modified="2015-07-22" version="1">MPRPADPARKTALLDSVVDYLVDHGLATLSMRPLAKELGQSTRVLTHHFADKADLLAATLARLDERQREWLAGLPGADGEMGMGEVVRATWEYHLTPEHLPLTRLIHEIEGLAAGDRLGGATSRLLADRVEFVAGWFRDRGVPAEAATGYATLLNAAFAGLQIDMLNTGDRERTTAAAHRLADLADGWVAASAGAREGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8Q0</accession>
    <name>A0A0F7N8Q0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_18285</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017133.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH83834">
        <property type="protein sequence ID" value="AKH83834"/>
        <property type="gene ID" value="AA958_18285"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_18285"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3843"/>
    <dbReference type="OrthoDB" id="1785082at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009594">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06719">
        <property type="entry name" value="AraC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="190"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH83834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="301" mass="32630" checksum="A9045B4DBF4E6845" modified="2015-07-22" version="1">MCLEELRTLLARHARPDWTTAIDGVLISKVDRSDPPSPSMSGTVLAVIAQGAKRLALGDRVYEYGPGQYLVASVDLPVTGQFTRADPELPALGFGFVLEPSAVAELLLQAGPGGTPRSGGGTPSGIAVSDASAPLLDAVVRLLRLLDEPRDRAVLAPLVKREILWRLITGEQGATVRQLGLADSSLSHVSRAVRWIREHYAQPFRVEDVARLSGMSVSAFYRNFQAVTAMSPIQFQKQIRLQEARLLLATHPGDVTGVAHRVGYDNPSQFSREYRRQFGAPPSRDAARLRDAVRAPATVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N920</accession>
    <name>A0A0F7N920_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_25605</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018285.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_25605"/>
    <dbReference type="EnsemblBacteria" id="AKH85035">
        <property type="protein sequence ID" value="AKH85035"/>
        <property type="gene ID" value="AA958_25605"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_25605"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5398"/>
    <dbReference type="OrthoDB" id="1204073at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH85035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="237" mass="25674" checksum="27C79667676107CA" modified="2015-07-22" version="1">MRILAVVWDIDDTIFDHSGAERRAALEYLTARGLLGRYASPGAAADHWHAVSEEYVDRYLAGEFTFLVQRRERARVLAGRRLTDAEADVWMAGYLAAYRRHWRVFPDVVPALDGLTPPRRHGLLSNSSAPHQEEKLRAIGVHDRFEALVCSEELGIAKPAAGAFHAACAALGLPPERVAYVGDRPDTDAAGADAAGLTGIWLDRPGAAARVAGKRAPDVRRITSPGQLGPLLGTLDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N921</accession>
    <name>A0A0F7N921_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nitroreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_19595</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017306.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_19595"/>
    <dbReference type="EnsemblBacteria" id="AKH84013">
        <property type="protein sequence ID" value="AKH84013"/>
        <property type="gene ID" value="AA958_19595"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_19595"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4129"/>
    <dbReference type="OrthoDB" id="1847197at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="2">
        <location>
            <begin position="426"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH84013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="542" mass="56977" checksum="8A002FE1824F9EEF" modified="2015-07-22" version="1">MGYAHGYATAIMHRGRVPMEPVDFVPDWADGPRKTKHYPGTDRLPLPAGPAYPAYATVERGLLTPAGGGGPAFDLGLLAGLLRDSYGLVGRRLGVQANTDLGALPFYPLANWSRGTASGGGLYPVSVYWVSGPSAPVPPGVHHYSPRHHALRRLLTGDVSGVVREALGEGAPGPETDQFLVLGVKYWQNSFKYNSFSFHAVSMDVGALLGTWRTWAGARGTALEPALWFDEERLARLLGVAGDEEGIFAVVPLPWAGYGAAARPGDGAPAAPLPAPPPEVSVRHRDRERSRTVLDFEALTAMQRATAADATARPAPGALAAAAAAPVAGRPETPLPRRAPLARDVRGALRARRSSFGRFAAERPLDGAHLTSCLAAAAGGARLGGDAAAAGADGLVTMYALVNHVAGVEPGTYAYVPDGDPGALRCVSAEPPGAFLQENYFLANYNLEQAAAVLVPTVRTHSVLDAVGDRGYRLVNALIGGVAQATYTAAAALDVGCGVALGFDNIAYRERFELLETDEMPLLIMMLGHERRGAADFRFEIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9B8</accession>
    <name>A0A0F7N9B8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Pentapeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_19685</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017321.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_19685"/>
    <dbReference type="EnsemblBacteria" id="AKH84029">
        <property type="protein sequence ID" value="AKH84029"/>
        <property type="gene ID" value="AA958_19685"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_19685"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4148"/>
    <dbReference type="OrthoDB" id="1677662at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001646">
        <property type="entry name" value="5peptide_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13599">
        <property type="entry name" value="Pentapeptide_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH84029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="244" mass="25960" checksum="E5FC96B86E44D47F" modified="2015-07-22" version="1">MGRMTRRKTIKAPRRPAVRLPASLARYGAGEEAAAGTYRAADLEPDGDYDALEFAGLDLTGADGAGARFMDCALRRCVLDAARLPAARLIDSVLEEVRGAGTDLAGATLRDVELTDTRLGGVQLHGATLERVVVRGGKADFLNLRGARLTDVVFEDCVLTEPDFGDARLERVAFEGCAIQRADLSGAHLKDVDLRRASQLTLDRGVDRLAGATISPDQLLALAPAFAAQVGVEVRAAGDVQKRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9I1</accession>
    <name>A0A0F7N9I1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HATPase_c domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_20065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017389.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_20065"/>
    <dbReference type="EnsemblBacteria" id="AKH84099">
        <property type="protein sequence ID" value="AKH84099"/>
        <property type="gene ID" value="AA958_20065"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_20065"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4227"/>
    <dbReference type="OrthoDB" id="1832160at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HATPase_c" evidence="1">
        <location>
            <begin position="25"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="227" mass="25039" checksum="D5DDE9990A4A38AF" modified="2015-07-22" version="1">MHKTDHPDRTVWGKCLVRKRWELDFPAHPEEVVGLRRVLRRHLRLWGLPHVVHAAQLCVTELVTNVICHVGTGVPVTLTTSMRDTRLRLELHDPGTNSVPILAKPTPDDETGRGLLLVAATAADWGVELRDDGKTTWVELATGLDSPTAHAGGDRVTAAEALLILYRQQHHRTLRANSPLSAAILEDAATHLIADVLRWLETHGCDPDTALARAESCLEDEIATTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9K5</accession>
    <name>A0A0F7N9K5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Topoisomerase II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_15515</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016694.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_15515"/>
    <dbReference type="EnsemblBacteria" id="AKH83382">
        <property type="protein sequence ID" value="AKH83382"/>
        <property type="gene ID" value="AA958_15515"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_15515"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3266"/>
    <dbReference type="OrthoDB" id="1424843at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045970">
        <property type="entry name" value="DUF5926"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004027">
        <property type="entry name" value="SEC_C_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19348">
        <property type="entry name" value="DUF5926"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02810">
        <property type="entry name" value="SEC-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5926" evidence="2">
        <location>
            <begin position="58"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH83382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="325" mass="34292" checksum="D72B6DEFED8BA569" modified="2015-07-22" version="1">MAKKRRPRTKASQPAAVPDGDIPVVGAREPCPCGSGRRYKACHGRAAAQAVTELVRRPFEGLPGECDWVALRELVPAGTAELTLAAGLPDDVPSLTLATVLPMAWPALRRDDGTVLLGLQNDTASGDISRDLADVLTRALTATPGSPVEPAAPTGTGEGPRLQDLLDTSAALRPVVHDGFAFWLDDAESASGEVAASLERANAAAIPTARLGGVEAAYWCEAPEKNHLRWVMPHPEEKLLDALARLHAAGHSQLAEDTRLVGSFRAHGLVVPVWDLPSSMTAEDCEKPAAEFGERLAEALAVTEPLTGTERKARGGLANRQVTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9N7</accession>
    <name>A0A0F7N9N7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0234 protein AA958_20905</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_20905</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0234 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017528.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_20905"/>
    <dbReference type="EnsemblBacteria" id="AKH84243">
        <property type="protein sequence ID" value="AKH84243"/>
        <property type="gene ID" value="AA958_20905"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_20905"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4405"/>
    <dbReference type="OrthoDB" id="1612988at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd11740">
        <property type="entry name" value="YajQ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00632">
        <property type="entry name" value="UPF0234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007551">
        <property type="entry name" value="DUF520"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035571">
        <property type="entry name" value="UPF0234-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035570">
        <property type="entry name" value="UPF0234_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036183">
        <property type="entry name" value="YajQ-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30476">
        <property type="entry name" value="PTHR30476"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04461">
        <property type="entry name" value="DUF520"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89963">
        <property type="entry name" value="SSF89963"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="162" mass="17948" checksum="C21137EC4C158892" modified="2015-07-22" version="1">MADSSFDIVSKVDRQEVDNALNQAAKEISQRYDFKGVGAAIAWSGERIEIRANAEERAKAVLDIFQSKLVKRGISLKALESGEPQASGKEYKLYSTVKEGISQDDAKKLAKIVRDEGPKGVKAQVQGDELRVTSKSRDSLQEVINLIKGKDLDFAVQFVNYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NA06</accession>
    <name>A0A0F7NA06_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Arabinan endo-1 5-alpha-L-arabinosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AA958_27555</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018599.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_27555"/>
    <dbReference type="EnsemblBacteria" id="AKH85365">
        <property type="protein sequence ID" value="AKH85365"/>
        <property type="gene ID" value="AA958_27555"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_27555"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5806"/>
    <dbReference type="OrthoDB" id="227867at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041542">
        <property type="entry name" value="GH43_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17851">
        <property type="entry name" value="GH43_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519219" evidence="7">
        <location>
            <begin position="28"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="domain" description="GH43_C2" evidence="8">
        <location>
            <begin position="612"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="27"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="43"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="245"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate" evidence="5">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH85365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="805" mass="85435" checksum="1E912C86FD1EA219" modified="2015-07-22" version="1">MRRTWTRTALLLCALLAGLLPLSSATAADPAPEPGPAQAPASAPASASASASASVSAKESTPGTYTNPVTDGVVDTFPDPVTIRGKDGYWYSYGTQNPVFQTGGEQGERMLPVLRSKDLANWEYAGEVFTPETQPEWHRGSRLWAPDIRYNDGHYTLYYSVPGRDTVGGATAPTPTGPWTDTGPVLPAPSGCPTGGIDQAQFTDRDGRTYLYWGSYDILCVAEMNADRTRITGEVTKVAQGRRMEGAFVVRRGDHYYLFYSDAGCCDGAYSGYQVKAGRSTSPTGPFRDDEGVDLMAPTSKGAIVLGANGNRWIGPGHNGLTTDLAGQDWLVYHGIPADAPDLDRFPELPDRQLTRRPMLIDRLDWIGGWPVVRAGAGPSEGPQRAPVTGWDAGGTFAGGSLDGWRAEGAGTGGWSVADDADSGPYATHGGGDGAAFLVTDRSAPRDLRAEADLRVTSSDGAAGLTVGYRDPRNHTTVWLDRARGALVTDVVVGGRSRGEQVTPLPASYDWDSWHNVTAEIRGGRMSVEVSGDRLRDAVAAQERKLPGAAVGTGAVGTAARGGGAAADNVGAARLHEPVTKRVPEPATGRLLPGYGDEFDTPAVPGTGPGSPWRWLRGPAPGVTADGGELVWPTQNGELHLNNNTASVLLRDAPEGDYTVTAKLDFDPAQPNQQAGLLLYADDDKYVKMTHSALPLNRGGGTVLDVSEFGKEGGRPTTSPPTPVANAPMFGGPTADTMWLRLSYHHDADNGEHEVRAATSRDGRAWVHNGVWTLPGDERLQTGLVSMNKEGAVAKFDYVRTHRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NA62</accession>
    <name>A0A0F7NA62_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Polysaccharide deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_21460</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017602.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_21460"/>
    <dbReference type="EnsemblBacteria" id="AKH84339">
        <property type="protein sequence ID" value="AKH84339"/>
        <property type="gene ID" value="AA958_21460"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_21460"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4518"/>
    <dbReference type="OrthoDB" id="1701876at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519356" evidence="2">
        <location>
            <begin position="31"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="3">
        <location>
            <begin position="129"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH84339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="311" mass="33667" checksum="C5DA982DA0CF6336" modified="2015-07-22" version="1">MRRTRRSGRRSSAAAIAAVCLLALTACADAARPTEEWFPQGAEESAAPGDGRADGKPGARHAGRTPRALPGGDGTARKDVPRATGPGAYRRWGLDRPLAAPPAPPASRPVRPGDSGLPAVAGRVPTRDKVVFLTIDDGWDKDPGFIRMAADLRLPFSMFLSDSAAGGDYGYFEELRRLGNSVHGHTLTHPDLTSLPYAGQRRQICRQQERVAGAFGVRPTLFRPPYGTYDAATLRAAASCGVRAMPLWRADMKASGLEYRSGDRLRPGDIVLAHFRGPEQQGGRTMTDVMAEFVREVQRQGFTVARLEDYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NA65</accession>
    <name>A0A0F7NA65_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Methylmalonyl-CoA mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_25065</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterodimer of an alpha and a beta chain.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018187.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_25065"/>
    <dbReference type="EnsemblBacteria" id="AKH84936">
        <property type="protein sequence ID" value="AKH84936"/>
        <property type="gene ID" value="AA958_25065"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_25065"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5282"/>
    <dbReference type="OrthoDB" id="154460at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004494">
        <property type="term" value="F:methylmalonyl-CoA mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016176">
        <property type="entry name" value="Cbl-dep_enz_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006099">
        <property type="entry name" value="MeMalonylCoA_mutase_a/b_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006098">
        <property type="entry name" value="MMCoA_mutase_a_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01642">
        <property type="entry name" value="MM_CoA_mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51703">
        <property type="entry name" value="SSF51703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00641">
        <property type="entry name" value="acid_CoA_mut_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="METMALONYL_COA_MUTASE" evidence="3">
        <location>
            <begin position="28"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH84936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="566" mass="62439" checksum="62A52BEB01050C2B" modified="2015-07-22" version="1">MDAAAMEEGRRRWQARYDAARKREADFTTLSGDDVEPVYGPRPGDVYEGFERIGWPGEFPYTRGLYATGYRGRTWTIRQFAGFGNAEQTNERYKLILGAGGGGLSVAFDMPTLMGRDSDDPHALGEVGHCGVAIDSAADMEVLFRDIPLGDITTSMTISGPAVPVFCMYLVAAERQGVDPGVLNGTLQTDIFKEYIAQKEWLFQPEPHLRLIGDLMEYCAERIPAYKPLSVSGYHIREAGSTAAQELAYTLADGFGYVELGLSRGLDVDAFAPGLSFFFDAHVDFFEEIAKFRAARRIWARWLRDVYGARSEKAQWLRFHTQTAGVSLTAQQPYNNVVRTAVEALAAVLGGTNSLHTNALDETLALPSERAAEIALRTQQVLMEETGVANVADPLGGSWYVEQLTDRIEADAEKIFEQIRERGRRAHPDGRHPIGPITSGILRGIEDGWFTGEIAESAFRYQRSLEKGDKKIVGVNCHTGSVTGDLEILRVSHEVEREQVRTLAVRRGARDDARVRAALADMLTAARDGGNMIEPMLAAVRAEATLGEICDALRDEWGVYTEPAAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAC4</accession>
    <name>A0A0F7NAC4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptide ABC transporter ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_25425</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018252.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_25425"/>
    <dbReference type="EnsemblBacteria" id="AKH85001">
        <property type="protein sequence ID" value="AKH85001"/>
        <property type="gene ID" value="AA958_25425"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_25425"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5359"/>
    <dbReference type="OrthoDB" id="1101128at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="26"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="60"/>
            <end position="67"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH85001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="365" mass="40179" checksum="2A5FBCD72DDD599A" modified="2015-07-22" version="1">MTGLTKTGAVGEPVPAAADASAFLDIRDLKVHFPTDDGVVKSVDGLSFQLEKGKTLGIVGESGSGKSVTSLAVMGLHTAGQYGKRRRAQISGEIWLNGQELLSAEPDAVRRLRGREMSMIFQDPLSALHPYYKIGYQIVEAYRVHHDVDKKTARKRAIEMLDRVGIPQPDKRVDDYPHQFSGGMRQRAMIAMALVNNPELLIADEPTTALDVTVQAQILDLIRDLQKEFGSAVIIITHDLGVVAELADDIVVMYGGRCVERGSAEQIFDRPQHPYTWGLLGSMPRIDREATDRLIPVKGSPPSLINVPSGCAFHPRCPYADVPADNASRTVRPELREVGTGHFAACHLRQEDRERIYTEEIAPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAS3</accession>
    <name>A0A0F7NAS3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_26380</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018412.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_26380"/>
    <dbReference type="EnsemblBacteria" id="AKH85171">
        <property type="protein sequence ID" value="AKH85171"/>
        <property type="gene ID" value="AA958_26380"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_26380"/>
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        <property type="match status" value="2"/>
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        <property type="entry name" value="PQQ_beta_propeller_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002372">
        <property type="entry name" value="PQQ_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
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        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00564">
        <property type="entry name" value="PQQ"/>
        <property type="match status" value="5"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AKH85171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="802" mass="81764" checksum="24AFBDD347667BCC" modified="2015-07-22" version="1">MEPLRLDDPEQFGAYRPVGRLDTDAGEMRAPAARYIAQAPGGERTVLITAPRTEATAADHGHAGRFHAAAAEAQRLGGTGGPWLAPVSELSATGPPWWAMPYRPALPLPAALDAQQGPLPERTVYAVGAALAETLASLHAAGMAHGGLDPTAVLLTGDGPLLTGYGTVSAAGADGSPRGSLAGLIPEFLPPEQAAGGRPRPLGDVYALAAVLLYAATGLLPGGQAADPQAGAFGDPLTDPLTGDPGYGPDPYAADPYATGAYGTPANPLDLLQPSLRAALEPCLHPDPARRPTAAALLPELLHAAAPGHSAAPGMGAAAPGTVLDAATTRSGAALAPGWLPRRVSAALALQAADVLAAETEPDPAFLAAPAPGPGTPDLIGGTTVIGRPATRRALIAGIAGGAVGVAAGGAAAWAATTEDPPPPPTTAERLAARTTGRKRLNGAPPPVLWGKGLGKVEPVGPPAVAAGTTALVVAKSGVFALDLRTGEELWEQSDVRASAPAVPLADGMVLVPGKDLTVLDAASGSVAWTSEKFRRGGKTPYRALLGVAGDTAAFTVEEGGELTVVGFDLAERRELWRSPGSAASTAALFPGGSVVLVPEADEDARHRDKPAAVSALDLGSGEERWAQEYAGMAGGHWAAAGRDLLVATAGKTMRGYDASGGDEVWSVTAEPWDEDVESTNPQNFGPPAVQGEMVHALDTFRAVHSVARDSGEEQWKRNPQLAYVGVLVQAPPLHVTPDEKVLIAGDDTQVLAYDADGGDLLWRFTDMRPGKPKYAHRRRVAVGKDTAVIASGSSVYALPLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBB9</accession>
    <name>A0A0F7NBB9_9ACTN</name>
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            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_19485</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_19485"/>
    <dbReference type="EnsemblBacteria" id="AKH83997">
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        <property type="gene ID" value="AA958_19485"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_19485"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4099"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH83997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="326" mass="34969" checksum="2BCAC94F5DEFBF39" modified="2015-07-22" version="1">MTSRILVTGVATPPGLALARALVPQADIVAVDADPYAAGLHIPGVTAHQLPAAADKKRYTEELLRLCSLEQPHALIPTTAQELPLLGRLAGRLQSMGVRTWLPSTRTAEACLDRCLLYTLLADRDVPTPRWWPAERTADIPHGVEVEVVSTSDHPKPVFAPIPCHSREQARMLCALLEPAAIQERLHGTEFTADCLVDNHGQASVILRHRHAIHGGVSMVTSTFHDPRAAAVVEQALEAAGIRGPACVRGVIRTAPRPAVVITGIDAHICGFACATAAGADYLGQFMGGLFGRPVDHGRLRYAPHVRLAQHHALLSVHGAPARTWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBE3</accession>
    <name>A0A0F7NBE3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_27935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018665.1">
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH85431">
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        <property type="gene ID" value="AA958_27935"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_27935"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5888"/>
    <dbReference type="OrthoDB" id="519404at2"/>
    <dbReference type="Proteomes" id="UP000034283">
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519934" evidence="1">
        <location>
            <begin position="32"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="396" mass="43313" checksum="3ECDD2E5C5686C44" modified="2015-07-22" version="1">MRGKYRTARAAVVAGIAVPALLLTAAPAGFAAATAPAAAPAAKPLPPDLPTHIEGGAWPTSHVQGVTVDTERNFVYWSFTQMLVKTDLDGNVIGTVEGLTGHLGDIDLSDRDGRVYGSLEYKAEEAFYIAVFDVDKIDRVGMNAETDGVMTAVHLDEVVADFTADMNGDGVFDGDTANTPDHRYGCSGIDGVSFGPEFGKRGGVQKLMVAYGVYSNTTRADNDHQVILEYDVRDWRRYERPLSQAEPHRSGPKRTDGKYFAYTGNTTYGVQNLQYDPYTRNWIMAVYDGVKEGFPNYSFFTVDGSKKPVRGEIKGQAKPEEGKLLTLRDAGLNDPATGVRGWEFHGNYGIDALGDGRYYVAEGRAVTEDGVRKQEGEVYLYRWTGETPTPFARVED</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBK7</accession>
    <name>A0A0F7NBK7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PBS lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_28660</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018790.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_28660"/>
    <dbReference type="EnsemblBacteria" id="AKH85556">
        <property type="protein sequence ID" value="AKH85556"/>
        <property type="gene ID" value="AA958_28660"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_28660"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6039"/>
    <dbReference type="OrthoDB" id="1421365at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004155">
        <property type="entry name" value="PBS_lyase_HEAT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03130">
        <property type="entry name" value="HEAT_PBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00567">
        <property type="entry name" value="EZ_HEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH85556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="203" mass="22269" checksum="B1168535FDC0DDD1" modified="2015-07-22" version="1">MDQEYLALTERIRGRLEDPPARARFEHMTALARQRTTTAHEELARVLEQPGEPLWARELAAFALGTAGDRRAFETLVLLLNYRDPVRAESAACALARLGDPRTARAAAALATNPLRTAYALHAIRLLVRLRAPESAPALISTLQRLVREPQHHWPIATACVEGLGELGDPRAIPALSEALGFPQLWRAATAAITRIGPRTPSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBM7</accession>
    <name>A0A0F7NBM7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HTH tetR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_28830</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018819.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH85586">
        <property type="protein sequence ID" value="AKH85586"/>
        <property type="gene ID" value="AA958_28830"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_28830"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6075"/>
    <dbReference type="OrthoDB" id="1570162at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025996">
        <property type="entry name" value="TetR_C_WHG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13305">
        <property type="entry name" value="TetR_C_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="3"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="4">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH85586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="204" mass="22260" checksum="D0F4E3E56AB8E194" modified="2015-07-22" version="1">MTADTRARLLEAALELLDERGVDALTLRAIARRCGVSHGAPLKHFPHRAALLSAVATQGFRELQDWAGEALAKLPADASPARRLRTGTRAYVEYAVARPEMFALMFRRDLLDPQDRELGRAALGGFENLVRLVEARQAEGWRADADPRLLTGALWSALHGTAELWSWGSLPLATGAATIDDVLDGLCEAFEIGPPTARRKRSTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBM8</accession>
    <name>A0A0F7NBM8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_20215</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017411.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_20215"/>
    <dbReference type="EnsemblBacteria" id="AKH84122">
        <property type="protein sequence ID" value="AKH84122"/>
        <property type="gene ID" value="AA958_20215"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_20215"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4257"/>
    <dbReference type="OrthoDB" id="2049098at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="2">
        <location>
            <begin position="45"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH84122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="216" mass="23240" checksum="8BAF9E6FEC6FE415" modified="2015-07-22" version="1">MTNATEEFGEAYWEEKYRARDAIWSGRPNTQLVTELAGLPPGTALEAGCGEGADAIWLAERGWRVTAVDISATALDRARAHAEARGAEVAGRITWVRADLTGSAPDGAPFDLVTTHYVHTTASRRALFGRLAAMVAPGGTLLVVGHHETDPRAADIAEAHPGVHFTAEDVAADLATDAWDIDVAEVRIRRAPEGHEPHGPDQPAEHHDAVLRARRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NC77</accession>
    <name>A0A0F7NC77_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">VanW family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_30480</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019054.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_30480"/>
    <dbReference type="EnsemblBacteria" id="AKH85826">
        <property type="protein sequence ID" value="AKH85826"/>
        <property type="gene ID" value="AA958_30480"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_30480"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6441"/>
    <dbReference type="OrthoDB" id="967747at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022029">
        <property type="entry name" value="PG-bd_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007391">
        <property type="entry name" value="Vancomycin_resist_VanW"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12229">
        <property type="entry name" value="PG_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04294">
        <property type="entry name" value="VanW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="PG_binding_4" evidence="2">
        <location>
            <begin position="98"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH85826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="578" mass="61052" checksum="99CBF326DF52E394" modified="2015-07-22" version="1">MLPSPGREAPDSPPAGRYRRPLVAGVAAAAVFGFLYVLGLLVGGDDIPSGTRVLDLDIGGMSRAEAAEKLERNWAELVPDRLPVRMGDETGELGSRAAGVTLDAEATVDDAAQSGSGPFTVIGRLFSGGGGDVEPVIRVDGEKSRAALASLAESYDREVRDGSITFHGGEPTAVQPRAGRSLDVDGALAELQAAAPDREDGPLALPVREVEPAVGAEEVDRAMAGFAAPAMSGPVTLTVRGGGEIEIAPEVLGEHLAMEPDGSDRLTPRLDGRGLFRASEVAAQVEQVSGEAENARLRWDGERVVVATEAAEGREITQEALAKAVLELLPGEGADARTGPVATRVDQPQLTGENAGRLGIKEQMSAFTVEFPPAPYRTQNVGQAAKLIDGSVVMPDDTWSFNDTVGERTEANGFVEGIIILDGKYTRATGGGVSAVATTVFNAAFFAGVDFEEYGAHSFYIERYPEGREATVAWGSLDLTFRNDSGNAIYVEASATEDSVTISFLGTRKYDEIESVKGPRTNVVEAGTRKGDADACEPQTPLEGFDVEVERIFKSGGREVDRESFKTTYTPRDSVTCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NC85</accession>
    <name>A0A0F7NC85_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphoenolpyruvate guanylyltransferase</fullName>
            <shortName evidence="1">PEP guanylyltransferase</shortName>
            <ecNumber evidence="1">2.7.7.105</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">fbiD</name>
        <name evidence="3" type="ORF">AA958_25755</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Guanylyltransferase that catalyzes the activation of phosphoenolpyruvate (PEP) as enolpyruvoyl-2-diphospho-5'-guanosine, via the condensation of PEP with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>GTP + H(+) + phosphoenolpyruvate = diphosphate + enolpyruvoyl-2-diphospho-5'-guanosine</text>
            <dbReference type="Rhea" id="RHEA:30519"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:143701"/>
            <dbReference type="EC" id="2.7.7.105"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; coenzyme F420 biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CofC family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.105" evidence="1"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018305.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_25755"/>
    <dbReference type="EnsemblBacteria" id="AKH85059">
        <property type="protein sequence ID" value="AKH85059"/>
        <property type="gene ID" value="AA958_25755"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_25755"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5425"/>
    <dbReference type="OrthoDB" id="1930370at2"/>
    <dbReference type="UniPathway" id="UPA00071"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043814">
        <property type="term" value="F:phospholactate guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052645">
        <property type="term" value="P:F420-0 metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02114">
        <property type="entry name" value="CofC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002835">
        <property type="entry name" value="CofC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40392">
        <property type="entry name" value="PTHR40392"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01983">
        <property type="entry name" value="CofC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03552">
        <property type="entry name" value="F420_cofC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1 3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="234"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH85059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="269" mass="26370" checksum="87D776990926055B" modified="2015-07-22" version="1">MTKRTAPAQTELPGRPDRPLWHVVVPLKPLALAKSRLGPAAGEPGRGRLALAFALDTVGAALGCPAVASVTVVTDDAEAAGQLTAAGARVVPDAPRAGLNAALAHGEQRVRAAAPGAAVAALNADLPALRPAELARVLAAAGGGRAFLADAPGVGTTLLAADAGAALAPGFGVASRARHLASGAREIGLRGVDSVRQDVDTGADLRAAMALGVGRHTAAALDRLAACGREVRDGEGAREGDGVRGRDGAPAGCPGHAPGTRAASDGVCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCA7</accession>
    <name>A0A0F7NCA7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribosome-recycling factor</fullName>
            <shortName evidence="3">RRF</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Ribosome-releasing factor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">frr</name>
        <name evidence="5" type="ORF">AA958_26015</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the RRF family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018345.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_26015"/>
    <dbReference type="EnsemblBacteria" id="AKH85104">
        <property type="protein sequence ID" value="AKH85104"/>
        <property type="gene ID" value="AA958_26015"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_26015"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5478"/>
    <dbReference type="OrthoDB" id="1674344at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006415">
        <property type="term" value="P:translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00520">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00040">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002661">
        <property type="entry name" value="Ribosome_recyc_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023584">
        <property type="entry name" value="Ribosome_recyc_fac_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036191">
        <property type="entry name" value="RRF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20982">
        <property type="entry name" value="PTHR20982"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01765">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55194">
        <property type="entry name" value="SSF55194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00496">
        <property type="entry name" value="frr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRF" evidence="4">
        <location>
            <begin position="21"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH85104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="185" mass="20799" checksum="3B9D68AB4AA65913" modified="2015-07-22" version="1">MIEETLLEAEEKMEKAVVVAKEDLAAIRTGRAHPAMFNKITADYYGAQTPINQLASFSVPEPRMAVVTPFDKSALRNIEQAIRDSDLGVNPSNDGNIIRVVFPQLTEERRKEFIKVARAKGEDARIAIRSVRRKAKETIDKAVKDGEIGEDEGRRGEKELDDTTHKYVAQVDELLKHKEAELLEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCG3</accession>
    <name>A0A0F7NCG3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mg chelatase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_25975</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Mg-chelatase subunits D/I family. ComM subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018339.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_25975"/>
    <dbReference type="EnsemblBacteria" id="AKH85098">
        <property type="protein sequence ID" value="AKH85098"/>
        <property type="gene ID" value="AA958_25975"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_25975"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5469"/>
    <dbReference type="OrthoDB" id="581802at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045006">
        <property type="entry name" value="CHLI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004482">
        <property type="entry name" value="Mg_chelat-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025158">
        <property type="entry name" value="Mg_chelat-rel_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000523">
        <property type="entry name" value="Mg_chelatse_chII-like_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32039">
        <property type="entry name" value="PTHR32039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32039:SF7">
        <property type="entry name" value="PTHR32039:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01078">
        <property type="entry name" value="Mg_chelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13335">
        <property type="entry name" value="Mg_chelatase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00368">
        <property type="entry name" value="TIGR00368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="232"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH85098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="540" mass="55442" checksum="23D1F2F79F192D9B" modified="2015-07-22" version="1">MAFARTCSVALVGVEGVVVEIQADLEPGVATFTLVGLPDKSLTESRDRVRAAVVNSGVDWPQKKLTVGLSPAAVPKSGSGFDLGIACATLGAAGRIAPDALTGLVMVGELSLDGRVRPVPGVLPAVLAAAAAGCCQVVVPEAAASEAALVPDVSVLGVRSLRQLIAILNDEPPPDEPPETGGAPAVPSARLAVPGAGWCAPAALGPGAYRPDLADVAGQHRARFALEVAAAGGHHLYLKGPPGAGKTMLAERLPGLLPPLTETEALEVTAVHSVAGTLPAGQPLVGEAPYAAPHHSATLPALIGGGNALPKPGAVSLAHRGVLFLDEAPEFSGRILDALRQPLESGHVVVARSAGVVQFPARFLMVLAANPCPCGLFARREGGCECPPMAIRRYQGRLTGPLLDRVDLRVAVDAVSRAELSAAGERAESTADAAARVLAARDRAAARYAGTAWRTNGEVPGHELRRRWHPAPGVLAPAERDLERGLLTARGLDRVLRVAWTIADLAGHDRPGPEDVAVALELRTGVPRGTRTQATTEPVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCH2</accession>
    <name>A0A0F7NCH2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Tryptophan--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Tryptophanyl-tRNA synthetase</fullName>
            <shortName evidence="8">TrpRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">trpS</name>
        <name evidence="10" type="ORF">AA958_21830</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the attachment of tryptophan to tRNA(Trp).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + H(+) + L-tryptophanyl-tRNA(Trp)</text>
            <dbReference type="Rhea" id="RHEA:24080"/>
            <dbReference type="Rhea" id="RHEA-COMP:9671"/>
            <dbReference type="Rhea" id="RHEA-COMP:9705"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78535"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8 9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.2" evidence="8"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017659.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_21830"/>
    <dbReference type="EnsemblBacteria" id="AKH84397">
        <property type="protein sequence ID" value="AKH84397"/>
        <property type="gene ID" value="AA958_21830"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_21830"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4597"/>
    <dbReference type="OrthoDB" id="951354at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004830">
        <property type="term" value="F:tryptophan-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006436">
        <property type="term" value="P:tryptophanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00806">
        <property type="entry name" value="TrpRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00140_B">
        <property type="entry name" value="Trp_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002306">
        <property type="entry name" value="Trp-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024109">
        <property type="entry name" value="Trp-tRNA-ligase_bac-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01039">
        <property type="entry name" value="TRNASYNTHTRP"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00233">
        <property type="entry name" value="trpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="8">
        <location>
            <begin position="201"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="15"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="24"/>
            <end position="25"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>L-tryptophan</name>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="153"/>
            <end position="155"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="201"/>
            <end position="205"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AKH84397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="339" mass="37272" checksum="A3A4010F9EB5B310" modified="2015-07-22" version="1">MAAPTRRPRVLSGIQPTAGSFHLGNYLGAVRQWVALQETHDAFYMVVDLHAITVPQDPQELRASTRLAAAQLLAAGLDPERCTLFVQSHVPEHAQLGWVMNCLTGFGEASRMTQFKDKAAKQGTANTTVGLFTYPVLQIADILLYQADAVPVGEDQRQHIELTRDLAERFNTRYGRTFTVPAPYILKETARIYDLQDPTVKMSKSASSPKGLLNLLDEPKSSAKKIKSAVTDTDTEIRYDPEAKPGVSNLLTIYSTLTGATVAELEQKYTGKGYGALKTDLAEVVTEWVTPFRSRTQEYLDDPETLDSLLAKGAEKARTVAAETLAEAYDKVGFLPAKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCP1</accession>
    <name>A0A0F7NCP1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cystathionine gamma-synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_22340</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017743.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_22340"/>
    <dbReference type="EnsemblBacteria" id="AKH84482">
        <property type="protein sequence ID" value="AKH84482"/>
        <property type="gene ID" value="AA958_22340"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_22340"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4704"/>
    <dbReference type="OrthoDB" id="637281at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808">
        <property type="entry name" value="PTHR11808"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00868">
        <property type="entry name" value="CYS_MET_METAB_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH84482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="381" mass="40037" checksum="FF484358CA3D5E6A" modified="2015-07-22" version="1">MSQPSFETVAIHAGQEPDPATGAVVPPIHQVSTYKQDGVGGLRGGYEYSRSANPTRTALEQNLAALEGGARGLAFASGLAAEDCLLRTALTPGDHVVIPDDAYGGSFRLFAKVAARWGVEFSVAHTGDPAAVRAALTDRTKLVWVETPSNPLLGITDIAASAAVAHEAGALLVVDNTFASPYLQQPLALGADVVVHSTTKYMGGHSDVVGGALVVADRELGERLTFHQNAMGAVAGPFDAWLVLRGIKTLAVRMDRHSANAARVAHMLDRHPRVTHVYYPGLEDHPGHETAAKQMRDFGGMVSFRVEGGEEAAVEVCNRARLFILGESLGGVESLIEHPGRMTHASAAGSPLEVPDDLVRLSVGIESVDDLLADLTQALGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCU6</accession>
    <name>A0A0F7NCU6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_27120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018529.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH85294">
        <property type="protein sequence ID" value="AKH85294"/>
        <property type="gene ID" value="AA958_27120"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_27120"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5715"/>
    <dbReference type="OrthoDB" id="1196738at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="22"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="280" mass="28946" checksum="7F6398E3111883FE" modified="2015-07-22" version="1">MTTVHANGVDLGIESFGADDAPLVLLAGGTTMLSWPDALCERLAAGGRRVVRYDLRDSGESTTVDPDAPAYTLRDLAADAAALVEVLGGGPAHLAGIGVGGMVAQVAALDHPRAFSALTLVGTRAVAPGPPDDDLPDHDGATMGRLFGQPMPDWSDREAVAEFTAAGAAILGDDPAAARVNGGRVWDRTPGTAPPVQMANHLGMVFSKLDCTPRWRERLPRIDIPTLVVHGRRDSFFPVGNGEAIAREIPGARLLVLETAATAIPDAAAGEVAEAMLALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCZ7</accession>
    <name>A0A0F7NCZ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PAS/PAC sensor protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_23090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_23090"/>
    <dbReference type="EnsemblBacteria" id="AKH84607">
        <property type="protein sequence ID" value="AKH84607"/>
        <property type="gene ID" value="AA958_23090"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_23090"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4867"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="2">
        <location>
            <begin position="27"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH84607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="849" mass="90705" checksum="86D34C4F45217A98" modified="2015-07-22" version="1">MRTRSRISKGGGRVGAPFWQSSPPGSIYDHIKVASFALDAEGHIEQWSARAEELLGISAAEVLGRDAVEALVPEELRADVGEKVAEILDGREWTGLLPYRRPAGPDGADAGHPAVDGIAELYVMPTTGVGGTRGAVCLTVDAYALRRIETDLAASQAVFGQAPMGFLLFGTDLRLVRVNERVAAAFGGTVASHAGRSPRDYLPRPEAERVTAALRQVLDTGEPVTDMQILGPTPEEPQTGSVPAQREGQPGSLRWSISLYRVHSRTGRPTGVAAIVSDVTHRRRAESEAASTRRNLALLNEAGARIGNSLDLETTARELLGVTVPQFCDMACVDVYQSLLDGDEGRPGLADGSAELRRVAFASAVSDAPVTAVGSTHRFDFHSPHAAALRTAQVRRVPGGDSGLVQTTLAVPLVAGDTVVGLVQFSRARGSEDFGERDAALAAQLASRAAVCIDNARLYRREHSRALILQRSLLPPGDPEAAGLDIACRYLPGNTATEVGGDWFDVIELPGHRTALVVGDVMGRGLRAAVAMGELRSAVRTLAMLDLEPAEVLAALDEIAGGLGGVSDEVYLATCSYVVYDAVTRRCTFANAGHLPPVVVEPGEPPLLLEVPPGMPLGVGGEPFEEVEVELPDGALLALYTDGLVESRDHGLDEGLEEFRKALSDPAQPLEDVCDHVLDTLYTRHGEDDIALLMARIGGLPADTVGDWLLPAEPRSVALAREHARTQLAAWDLEPLIDTTELLVSELVTNALRHGEGGRSGGGEPEIRLRLLLDRTLVCEVWDSNLVQPRRRRARDTDEGGRGLQLVSMLSRNWGSRRTHRGKTVWFELALPGTGPLAEVDEDALLSAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7ND54</accession>
    <name>A0A0F7ND54_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_32490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86156">
        <property type="protein sequence ID" value="AKH86156"/>
        <property type="gene ID" value="AA958_32490"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_32490"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6857"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="304" mass="32587" checksum="C9DC9E1466D062FD" modified="2015-07-22" version="1">MRIGSRSGTPSWSGPDRSPGTGTRPSRHPPAARASRGGPSSGRGTARRRAAAGVELTTRPRARCAGRPRWAPHCCRRATRGRRQGTLSPWWPSRTSTARAALPRTALRRLPSPASCIRVASLIWMPTSYRANLRRTLEPVRNRRDGEAGRMLDDCGGTPVLAGGRRHFSSVQGGGVAPDQALAARDSWRGDLQFVGLTGHSTCDGTSSRSGGAGQPFHSSARTPRPGAPAETSCKVPLWRLPCACQAGDTSPTVIVCLHRLRPRRRQVLRLRTDGSGRGRDGPTGAPCQDLGWTRSHAWASALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDC0</accession>
    <name>A0A0F7NDC0_9ACTN</name>
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        <submittedName>
            <fullName evidence="2">Beta-lactamase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_01440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86485">
        <property type="protein sequence ID" value="AKH86485"/>
        <property type="gene ID" value="AA958_01440"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_01440"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.317"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="57"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="283" mass="29490" checksum="598154FEBD4F9A8C" modified="2015-07-22" version="1">MAVCRAGQFEVVALLDAHGTFPLSRTDAFPGASAGAWADARRVDPRAFGPGDSWELDFRCFAVRRPGGRVVLVDSGIGAAGSPAASWAPVPGLLPGRLAAAGIAPGDVDAVVLSHLHEDHYGWSVTPDGRPAFPRARYVVQAAELAALAPGDSAVRYAVDPLRAAGRLHVVDGGTRLAGGRGGAVTLVPTPGHTPGHQSVVVDGGRRQIVIAGDVLVHAVQLADPAVRYFFEEDPGLAHRTRRLLLERARERGAVLATAHLNLPFVPLGRPGADGRPPAFSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDR1</accession>
    <name>A0A0F7NDR1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_09560</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019909.1">
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86645">
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        <property type="gene ID" value="AA958_09560"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_09560"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2015"/>
    <dbReference type="OrthoDB" id="2033758at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519982" evidence="2">
        <location>
            <begin position="32"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH86645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="153" mass="14634" checksum="A9A67852B560C373" modified="2015-07-22" version="1">MGQHASRFPSRTQRALLRAGLTAAAAGSALAAGGAAGAAAAPADGPASRALDTLDELKVGEDNEIDAEQVAAALAGVSQGVDTTRQTALGPLTALRLNPMAKTGSDPLDNSVGTAVGEGGAPVSTAAVTGPLAEGASLGELPTAGPVVSGLVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-10-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDU7</accession>
    <name>A0A0F7NDU7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_33935</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="PTM">
        <text evidence="1">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019628.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86406">
        <property type="protein sequence ID" value="AKH86406"/>
        <property type="gene ID" value="AA958_33935"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_33935"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.7165"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035398">
        <property type="entry name" value="Bac_rhamnosid_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17390">
        <property type="entry name" value="Bac_rhamnosid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase" evidence="2">
        <location>
            <begin position="96"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_rhamnosid_C" evidence="3">
        <location>
            <begin position="177"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="1">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600917-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH86406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="258" mass="28424" checksum="A0E9AE1472585996" modified="2015-07-22" version="1">MPLAWYEGRKAVVDDADPATAARRLTDAALDFVDDHRDGPFLAVLSHLGPHAPYRVEPRFHGASAAGAYGDLVEQLDHYLGVLLRHLDRRRLTRRTLVIVYCDDLGYGDPGCHGSPLVTTPVIDGMARRGMRLADFYAGAPTCTPSRASLLDRLLRAAREPRDRALPRPHQRAVVARDVAARLETVRGTVASPWRRQADGRTGMEVTVPYHTTAEVCIPVRGTAIRSLRSPLPAARDHPGGERYAVYRATAGTYRFTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NE25</accession>
    <name>A0A0F7NE25_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Septum determining protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_13010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020013.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_13010"/>
    <dbReference type="EnsemblBacteria" id="AKH86730">
        <property type="protein sequence ID" value="AKH86730"/>
        <property type="gene ID" value="AA958_13010"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_13010"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2738"/>
    <dbReference type="OrthoDB" id="1824297at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012495">
        <property type="entry name" value="TadE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07811">
        <property type="entry name" value="TadE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="131" mass="13556" checksum="89A3BA25650DCB65" modified="2015-07-22" version="1">MTTIEVVILAPVMFLFILVLVAFGQLVDGRGGVDGAARDAVRAASLQRTVGEAQRAAQRAAESQLEGDVCTGPVDVDLSGDFSPPEPGAASNIITVEVTCEVKGLGMLGLDIDPRMTGSSSAPLDPYRRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NE34</accession>
    <name>A0A0F7NE34_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ArsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_25045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018183.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH84932">
        <property type="protein sequence ID" value="AKH84932"/>
        <property type="gene ID" value="AA958_25045"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_25045"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5278"/>
    <dbReference type="OrthoDB" id="1617768at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045981">
        <property type="entry name" value="DUF5937"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19361">
        <property type="entry name" value="DUF5937"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="256"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="330" mass="35665" checksum="3D1A1042627D4833" modified="2015-07-22" version="1">MPMYMRFGPEDLLRCRFAISPVFETHEAIRTLRRTERHGYHRPWLRSLGDAAAGLDLAPLWIFMPNPGPGYTPDFLGGPPRDTYTSVADGLARLRATDPALAHAEMTMSFGTIPGAAESPLGRKLLADPAAAISLMADLTERAWHMLVEPFWPRLRDLLEADIDYRARQLASAGLGELFALLHHRLSYADGLLTVSTKSRDRYERDLAGDGLLLMPSAFVWPDVVTGFQPPWQPTVIYPARGVGSLWAEPGPGAGQALAKLLGGGRASVLAALDEPASTSALARRLGLAPSSVSAHLTVLKAAGLLTSHRERHRVLYERTPLGGALAAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NE90</accession>
    <name>A0A0F7NE90_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_15010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_15010"/>
    <dbReference type="EnsemblBacteria" id="AKH86780">
        <property type="protein sequence ID" value="AKH86780"/>
        <property type="gene ID" value="AA958_15010"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_15010"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3163"/>
    <dbReference type="OrthoDB" id="1262421at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006976">
        <property type="entry name" value="VanZ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04892">
        <property type="entry name" value="VanZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519992" evidence="2">
        <location>
            <begin position="26"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="VanZ" evidence="3">
        <location>
            <begin position="7"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH86780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="153" mass="16601" checksum="ECD6C124F9306C4E" modified="2015-07-22" version="1">MLVAFALMVAFAVVLARLTLEGSSASEPVTHTNLRPGDSIRDYLTQPAFVDTVRQLGGNILLGVPFGLLLPVLVPPARGLLRVGLCTAAVMTAVEVVQGTFLTGRAFDIDDVILNTTGAFLGYLFLGRRLGRAVHPPRRRWWHRVFRGPRPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NE98</accession>
    <name>A0A0F7NE98_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_15305</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_15305"/>
    <dbReference type="EnsemblBacteria" id="AKH86790">
        <property type="protein sequence ID" value="AKH86790"/>
        <property type="gene ID" value="AA958_15305"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_15305"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3222"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014322">
        <property type="entry name" value="RNA_pol_sigma-B/F/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02980">
        <property type="entry name" value="SigBFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00715">
        <property type="entry name" value="SIGMA70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519406" evidence="6">
        <location>
            <begin position="29"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_sigma70" evidence="7">
        <location>
            <begin position="135"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="40"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH86790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="331" mass="35355" checksum="B17451600DA5BF47" modified="2015-07-22" version="1">MSARTAPPVPCPPASSPASPPPPGPAPAATTAATAAPGPASAAPGPPAAPADPAAAADPDPAPGGSGASAGSGDPEAPRKPDSRALTRALFAELTALEPGTPEHTRVRTALIEANLPLVRYAAARFRSRNEPMEDVLQVGTIGLIHAIDRFDPARGVQFPTFAMPTVIGEIKRYFRDNVRTVHVPRRLHELWAQVSGATEDLTVRHGRAPTTAEIAAHLKIGEEEVRACREAGRSYYATSLEAAQEGDGMPGLLDRLGYEDPALAGVEHRDLVRHLLVQLPEREQRILMLRYYRNMTQSQISAELGLSQMHVSRLLSRSFARLRSANRIDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NEA8</accession>
    <name>A0A0F7NEA8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ketoacyl reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_30270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019022.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_30270"/>
    <dbReference type="EnsemblBacteria" id="AKH85794">
        <property type="protein sequence ID" value="AKH85794"/>
        <property type="gene ID" value="AA958_30270"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_30270"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6395"/>
    <dbReference type="OrthoDB" id="1094766at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="261" mass="26910" checksum="FB046986ED72BE80" modified="2015-07-22" version="1">MTHQPARVALVTGATSGIGLSVATLLASQGHQVFLGARTEDGVVATVKSLKDKGYDVEGQVLDVRGTDSIESFVRAAVETFGDVAVLVNNAGRSGGGVTADIADELWDDVIDTNLNSVFRMTRAVLTLGGMRNRDSGRIINIASTAGKQGVVLGAPYSASKHGVVGFTKALGNELAPTGITVNAVCPGYVETPMAQRVRQGYAAAYETTEAAILAKFQAKIPLGRYSTPDEVAGMVGYLASDTAASVTSQALNVCGGLGNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NEC0</accession>
    <name>A0A0F7NEC0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex</fullName>
            <ecNumber evidence="3">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_16465</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="3"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020131.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_16465"/>
    <dbReference type="EnsemblBacteria" id="AKH86825">
        <property type="protein sequence ID" value="AKH86825"/>
        <property type="gene ID" value="AA958_16465"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_16465"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3465"/>
    <dbReference type="OrthoDB" id="1626282at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="SSF47005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="5">
        <location>
            <begin position="4"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="6">
        <location>
            <begin position="202"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="154"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH86825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="514" mass="51671" checksum="C566BFED15832D85" modified="2015-07-22" version="1">MPEVREFALPDLGEGLTEAEIVTWLVDVGDVIAVDQPVVEVETAKAMVEVPCPYGGVVTARHGDPGTEVPVGSVLVTVAVEAGTGPGPGPGSGGGYRDRIEDRIRSAGAADGGPAGADDGARADGAVADARAAAEFAGEETGGSGNVLVGYGTSAGGARRRRRSAGAGRTALGGGPVRPGAGAPAPRGAKAPAVPADGPVAVISPLVRRIARESGLDLRAITGSGPHGLILRADVEAAVRAGTPAGRGAAAAAGRTAVDDGAAVAGASTAGPGKAGAVAPGGGLAEGERVPLRGVRGAIADKLSRSRREIPDVTCWVDADATELLDARRAMNAAAGDRPAVSLLALLGRVCTAALARYPELNSTVQGREIVRLPAVHLGFAAQTDRGLVVPVVRDAHALSAERLSAEMARLTEAARAGTLTPAELTGGTFTLNNYGVFGVDGSTPILNHPEAGMLGVGRIAEKPWVYGGELAVRRVVELSFTFDHRVCDGGTAGGFLRYVADCVEHPAVLLRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NEC1</accession>
    <name>A0A0F7NEC1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3-isopropylmalate dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.85</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">3-IPM-DH</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Beta-IPM dehydrogenase</fullName>
            <shortName evidence="3">IMDH</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">leuB</name>
        <name evidence="5" type="ORF">AA958_25615</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>(2R,3S)-3-isopropylmalate + NAD(+) = 4-methyl-2-oxopentanoate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:32271"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.85"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="3">Binds 1 Mg(2+) or Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.85" evidence="3"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018287.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_25615"/>
    <dbReference type="EnsemblBacteria" id="AKH85037">
        <property type="protein sequence ID" value="AKH85037"/>
        <property type="gene ID" value="AA958_25615"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_25615"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5401"/>
    <dbReference type="OrthoDB" id="1551125at2"/>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00072"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003862">
        <property type="term" value="F:3-isopropylmalate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01035">
        <property type="entry name" value="LeuB_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023698">
        <property type="entry name" value="LeuB_actb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 3" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Iso_dh" evidence="4">
        <location>
            <begin position="6"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="219"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="279"/>
            <end position="291"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="3">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="3">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH85037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="346" mass="36531" checksum="85D15BA343D7DC6A" modified="2015-07-22" version="1">MSRSIRLASIPGDGIGPEVVAQGLKVLSAVLPQDVKLETESYDLGARRWHATGETLPDAELTALKDFDAILLGAIGDPSVPSGVLERGLLLKLRFAFDHYVNLRPSKLFPGTETPLAGRPAIDFVVVREGTEGPYTGNGGSLRTGTPAEVATEVSVNTAYGVERVVRDAFERAQARPRRKLTLVHKNNVLVYAGHLWKDTFDRVGAEYPDVTTDYLHVDAATIFLTTRPERFDVIVTDNLFGDILTDLAAAISGGIGLAASGNINPAGAFPSMFEPVHGSAPDIAGTGKADPTATVLSVALLLRHLGYAAQAARVEKAVEADLAARGSAARTTDEIGDALAARVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NEF1</accession>
    <name>A0A0F7NEF1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4 5">Acylphosphatase</fullName>
            <ecNumber evidence="3 4 5">3.6.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_25860</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 4 5">
            <text>an acyl phosphate + H2O = a carboxylate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:59918"/>
            <dbReference type="EC" id="3.6.1.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the acylphosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.7" evidence="3 4 5"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018320.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_25860"/>
    <dbReference type="EnsemblBacteria" id="AKH85077">
        <property type="protein sequence ID" value="AKH85077"/>
        <property type="gene ID" value="AA958_25860"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_25860"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5446"/>
    <dbReference type="OrthoDB" id="2034659at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003998">
        <property type="term" value="F:acylphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020456">
        <property type="entry name" value="Acylphosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001792">
        <property type="entry name" value="Acylphosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036046">
        <property type="entry name" value="Acylphosphatase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017968">
        <property type="entry name" value="Acylphosphatase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47268">
        <property type="entry name" value="PTHR47268"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00708">
        <property type="entry name" value="Acylphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54975">
        <property type="entry name" value="SSF54975"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00150">
        <property type="entry name" value="ACYLPHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00151">
        <property type="entry name" value="ACYLPHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51160">
        <property type="entry name" value="ACYLPHOSPHATASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acylphosphatase-like" evidence="7">
        <location>
            <begin position="6"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="21"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH85077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="93" mass="10249" checksum="5D7125E3839723F3" modified="2015-07-22" version="1">MSTDVRMTAWVRGVVQGVGFRWFTRARALEIGGLSGFAANLADGRVQIVAEGPRAQCQELLEWLRSADTPGRVSGVTEIWDEPRGGYHSFAIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NEQ9</accession>
    <name>A0A0F7NEQ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_15025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_15025"/>
    <dbReference type="EnsemblBacteria" id="AKH86781">
        <property type="protein sequence ID" value="AKH86781"/>
        <property type="gene ID" value="AA958_15025"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_15025"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3166"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxi_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00046">
        <property type="entry name" value="DAGKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="SSF111331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="SSF48317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAGKc" evidence="1">
        <location>
            <begin position="195"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="497" mass="51352" checksum="235335DD4FF6270B" modified="2015-07-22" version="1">MAGTRRLRRADHALFARIAATRWPGAEPVLPRLSRAADHGVLWFGTAAAVAAFGGPRGRRAALRGLGSLALASATANTAGKGAFRRARPVLDAVPVIRHLTRQPITSSFPSGHTASAAAFACGVAMESPRWGLALAPVAWSVAFSRIYTGAHYPSDVLAGAALGLGAALVVRRLAPPRARGTHPAPPPAEAPALPGGAGLYVVVNPASGAQQFGDPVQQLATVLPEARVALADTPAGPGAGPLPELLDTAAREAARHGGALGVCGGDGTVAAAAEAALRHGVPLAVLPGGTFNHFATDLGVESIAEAGEAVTHGSAVAVDVGRLRPREPAGPPALFLNTFSLGVYPELVRRREHFPPPFRGPLGTVAAVLRVIRTAQPVSARINGRRREVWLLFAGSGAYHSVGIAPVRRDNLADGVLDVRIARAGDFARARLLATALAGGLARTRLYAAGRLRRIVVSGLPEGTRMAYDGEVVPAPTAFELDKLERALTVYRPARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NET5</accession>
    <name>A0A0F7NET5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">von Willebrand factor A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_21695</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_21695"/>
    <dbReference type="EnsemblBacteria" id="AKH86950">
        <property type="protein sequence ID" value="AKH86950"/>
        <property type="gene ID" value="AA958_21695"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_21695"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4570"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008912">
        <property type="entry name" value="Uncharacterised_CoxE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05762">
        <property type="entry name" value="VWA_CoxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH86950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="371" mass="39379" checksum="51DD8B4B499F9F22" modified="2015-07-22" version="1">MVLGGEGGGDGTGAALGGDDAGMDQVLAALYGGAEQPGRSGRRRAGLGGSAPQVARWLGDVREYFPTPVVQVMQRDAIDRLGIASLLLEPEMLAAVEPDVHLVGTLLSLAKAMPDEARETARTVVRQVTDDLERKLAARTRATLTGALDRAARVQRPRHRDIDWDRTIRANLKHYVPEHRTVVPERLVGYARAARSVRKEVVLAIDQSGSMAASVVYASVFGAVLASMRSLATRLVAFDTAVVDLTDQLSDPVDVLFGTQLGGGTDINRALAYCQQRITRPADTVVVLISDLYEGGIRQEMLKRVAAMKASGVQFVVLLALSDEGAPAYDRDHAAALAALGAPAFACTPELFPEVMAAALEGRPLPVPAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NF21</accession>
    <name>A0A0F7NF21_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_31935</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019292.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_31935"/>
    <dbReference type="EnsemblBacteria" id="AKH86064">
        <property type="protein sequence ID" value="AKH86064"/>
        <property type="gene ID" value="AA958_31935"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_31935"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6744"/>
    <dbReference type="OrthoDB" id="816674at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH86064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="404" mass="44489" checksum="EB24EF4B0AC46607" modified="2015-07-22" version="1">MPRRPGPAPAHTRRTRFDPAAELRAIAAERPVTRIDVGPGDSEEYVWLVTGYDEVRQVLGDHVRFSTRRRFGRAARADGTYPDDHRPDDMIGQLMDYDPPEHTRLRKMLTPEFTVRRVRRLRPRIEEIVAGRLDAVERAGPPADLVEQFATPVSGAVLCELIGVPRDDRDAFLRRARHHLDQGRGRQARAAAGAAFSRYLAALVAGQRRDPDDGFLGMLVRDHGADVTDKELRGVCVLLMLAGLDNVSGMLSLGTLVLLEHPGRLAEIRADPGAVDRTVDELLRYLTVPHAPTPRTALEDVTVGGQLVRAGEHVVVSLPTANRDPALTADPDRFDPARGPAAHLAFGHGIHHCLGAALARMELGIGYTALLRRFPRLRLAAPAAEVPFRLHTTAYGLERLPVAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-12-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NF57</accession>
    <name>A0A0F7NF57_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_29185</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH87105">
        <property type="protein sequence ID" value="AKH87105"/>
        <property type="gene ID" value="AA958_29185"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_29185"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6153"/>
    <dbReference type="OrthoDB" id="1832218at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="PTHR21240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="2">
        <location>
            <begin position="9"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH87105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="290" mass="31589" checksum="9A2022647EF5D7A7" modified="2015-07-22" version="1">MDVDGLAAIDVHTHAEVSSKGHASLDEGLHEASSAYFKVRGKRRPTLEETAAYYRERNMAAVVFTVDAESATGTAPVPNEEVAEAAAANPDVLIPFASIDPFRGRAGVQQARRLVEEYGVRGFKFHPSIQGFYPDDRLAYGLYEVIEETGAIALFHTGQTGIGAGVPGGGGIRLKYSDPMRVDDVAADFPHLKIILAHPSFPWQDEALAVATHKPGVHIDLSGWSPKYFPPLLVKYANSLLKDKVLFGSDYPVLTPDRWLADFAELPIKDEVRPAILKENAARLLGLTRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NG14</accession>
    <name>A0A0F7NG14_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_33700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019586.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_33700"/>
    <dbReference type="EnsemblBacteria" id="AKH86364">
        <property type="protein sequence ID" value="AKH86364"/>
        <property type="gene ID" value="AA958_33700"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_33700"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.7115"/>
    <dbReference type="OrthoDB" id="1984437at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041581">
        <property type="entry name" value="Glyoxalase_6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18029">
        <property type="entry name" value="Glyoxalase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyoxalase_6" evidence="1">
        <location>
            <begin position="8"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="127" mass="13828" checksum="B8679F88BE3A596D" modified="2015-07-22" version="1">MTSVVQNIAIDCADAYGLSLFWSKVTGSPVHPEDGPGSPETQVLLPEGPVLHFNQVPERKTGKNRIHLCLRPETGREEEVERLLRLGASFVADHRNPDGTGWAVLADPEGNEFCVLRSAAERAATQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NG66</accession>
    <name>A0A0F7NG66_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AsnC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_33435</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018835479.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_33435"/>
    <dbReference type="EnsemblBacteria" id="AKH86318">
        <property type="protein sequence ID" value="AKH86318"/>
        <property type="gene ID" value="AA958_33435"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_33435"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.7061"/>
    <dbReference type="OrthoDB" id="1844486at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019885">
        <property type="entry name" value="Tscrpt_reg_HTH_AsnC-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13404">
        <property type="entry name" value="HTH_AsnC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00519">
        <property type="entry name" value="HTH_ASNC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH86318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="146" mass="16003" checksum="F38CF29A043226F0" modified="2015-07-22" version="1">MEELDRHIVELLVRDGRMSYTDLGKATGLSTSAVHQRVRRLEQRGVIRGYGAIVDPEAIGLPMTAFISVKPFDPSAPDDIADRLAEVPEIEACHSVAGEENYILKVRVAAPAELEDLLARIRSLAGVSTRTTVVLSTPYEARPPRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NGC0</accession>
    <name>A0A0F7NGC0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thioesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_30290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019025.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_30290"/>
    <dbReference type="EnsemblBacteria" id="AKH85797">
        <property type="protein sequence ID" value="AKH85797"/>
        <property type="gene ID" value="AA958_30290"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_30290"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6399"/>
    <dbReference type="OrthoDB" id="1694750at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="34"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="286" mass="30285" checksum="D74DD66C475A32C9" modified="2015-07-22" version="1">MTADPRPVVLEAAGIRLSALLSEPAGDRPPLATVVALHGGGMTASYFDARARPGLSLLELGATLGFAVLAVDRPGYGRSAARLPEGVSLSRQTRLLRAGLADFAERHPTGAGTFLLAHSYGGKLALSLAAAAGTGDRLLGLDVSGCGHRYAALPGATPGAGPSRRDTLRHWGPLRLYPPGTFRAGRGMTTPMPGREAAGLPRWPRLFARLAPRVRVPVRLTFAEHERWWRHGEPDLADLAGRFTASPRVQVDRQPGAGHNISLGWAARAYHLRALAFLTECLTPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NHI4</accession>
    <name>A0A0F7NHI4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Gas vesicle structural protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_32805</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the gas vesicle protein type A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019434.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_32805"/>
    <dbReference type="EnsemblBacteria" id="AKH86207">
        <property type="protein sequence ID" value="AKH86207"/>
        <property type="gene ID" value="AA958_32805"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_32805"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6931"/>
    <dbReference type="OrthoDB" id="1815258at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031411">
        <property type="term" value="C:gas vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012506">
        <property type="term" value="C:vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000638">
        <property type="entry name" value="Gas-vesicle_GvpA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018493">
        <property type="entry name" value="Gas-vesicle_GvpA_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00741">
        <property type="entry name" value="Gas_vesicle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00234">
        <property type="entry name" value="GAS_VESICLE_A_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0304">Gas vesicle</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0926">Vacuole</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH86207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="127" mass="14111" checksum="BB1D6D808627B295" modified="2015-07-22" version="1">MTDHVLDRPLTHLPSTPSGPANLADILERVLDKGIVIAGDIKIDLLDIELLTIRLRLFVASVETAKKAGIDWWETDPALSTRAHRDAVDEENARLRERVAELEASVEGHRPERAGADGWESVRKGHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NHW3</accession>
    <name>A0A0F7NHW3_9ACTN</name>
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            <fullName evidence="4">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_18195</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="AA958_18195"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="76"/>
            <end position="104"/>
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    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
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        <location>
            <begin position="183"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="140"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH86863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="383" mass="40483" checksum="A494613B61DBC5E8" modified="2015-07-22" version="1">MTGAWLIAVDTAPEDNEHAPLTDVAKTIALVIGIGYAVVVALRRRCPERMLLVAGGLGVVQVVVDSSPGPANFAMLVVIFTVAAGDVPWASRLALIGAAVAPVVNQLRWPAASENFVQQTVGLAFLTVPFLLAWVLGDSLRTRRAYYAQLEERAARLERERETQSRIAVAAERARIARELHDVVAHNVSVMVVQADGAAYVLDSAPQQAKEALTTISGTGRQALAEMRRLLGVLRTGDPGAGSEYVPQPGVEQLAELVEQVRGAGLTVSFEVAGSPRELPSSIELAAYRIVQEALTNTRKHGGPEAGAAVRLTYAEGELQVLVEDDGRGSLPELYEEGGADGQGHGLIGMRERVGMTGGELDAGPRPGGGFRVRAVLPLKTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NI26</accession>
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        </submittedName>
    </protein>
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    </gene>
    <organism evidence="3 4">
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        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AKH86417">
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        <property type="gene ID" value="AA958_34000"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_34000"/>
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    <dbReference type="Proteomes" id="UP000034283">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH86417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="185" mass="19974" checksum="C8AA14D9796D759B" modified="2015-07-22" version="1">MPGDRLMRIHSAEFRAMAERVLRVTELTSRLNILPFEDEAGKADLFKQILGKPLPPGVTIYPPFYTDHGLNLDLAERVFINQNCTFLDYAGIRLGERVMIGPKATFITSGHPVDPGERRLYLTGAPINVAENVWIGAGATILPGVTIGRDAVVAAGAVVADDVPPASLVTGSKATVHRTWVSGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NID3</accession>
    <name>A0A0F7NID3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_03035</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019749.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_03035"/>
    <dbReference type="EnsemblBacteria" id="AKH86522">
        <property type="protein sequence ID" value="AKH86522"/>
        <property type="gene ID" value="AA958_03035"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_03035"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.647"/>
    <dbReference type="OrthoDB" id="1221455at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
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        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="300"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl_transf_3" evidence="2">
        <location>
            <begin position="15"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH86522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="394" mass="42422" checksum="FCC36AC34E5F9387" modified="2015-07-22" version="1">MSGNDKGSPGTPRDPYFDNVKFLAVVLVACGHAWEPLVDGSRAVAAAYETVYAFHMPLFVLVSGYFSRGQDGSPRRARGLITGLAVPYLVFETAYTLFGRHAGDNASPFSLLDPWGVTWFLLALFVWRLSVPLWTALRHPLPVALAVAALATATPGIGNDLELQRVLQLLPFFVLGLTCAPEPLRLLRRREARILAAPVLLAAPVAAYLLGPHTDRRWLYRSTAAQEIGYSGTTGLLAVPVLFCCSLLLAAAFLAWVPGRRLWWTVLGTGTLYGYLLHAFATQGVRYGGWYEPAWLSTPAGPVAVTLAAAAGMALLCSPPVRRALRWAVEPRLAPLFRPAGSVPSRAPRSVESRGLAPMPARAPFTVVGCTTAGCTSPAGHRPPGGHDEEPQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NIF7</accession>
    <name>A0A0F7NIF7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_00105</name>
        <name evidence="3" type="ORF">AA958_34150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86453">
        <property type="protein sequence ID" value="AKH86453"/>
        <property type="gene ID" value="AA958_00105"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH87224">
        <property type="protein sequence ID" value="AKH87224"/>
        <property type="gene ID" value="AA958_34150"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_00105"/>
    <dbReference type="KEGG" id="strc:AA958_34150"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.24"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007403251" evidence="1">
        <location>
            <begin position="28"/>
            <end position="650"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH87224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="650" mass="70470" checksum="D31AE7B20732F47A" modified="2015-07-22" version="1">MPGLSRRTLLVGAGAAALLTATGGAIPATFAAQPPADQPTAAEAGLPTIAPLPAGAPDRSLFSHPEQRLAPYLVTLAPMVNEIVTDGSEQHGWMAGGWWRTPTEPFNARIQEHVRTLAWFATTERPWNPYHGDPALLARLDAALGHYLSLQHENGSWPEYAPDEHSRAATAFALGYLSKTLQDLRRTGHLPETQQAIAAALRRAVTWFLDPGNTGVWQHGPIEFVNQPMAGLAGASLALHLDPAPALRAQLHDRIADIVARGQSPAGYFYEPRGMDIAYNLNVTLSEIVEILDHHDKPELVAMVERLADWLGYNLVREPDGAGFIANTAGSARTPMYYLDDVTAEPQQRDLGSWFTPLVPAMAAFYPTAGDRTAQRAAWAADPAPVPQQERGATNPRILVNIPYGERYPSAAAKAAAIATLPYLASRRFTELRRDPGGEDYLFVRRPGYYTMAHYGPQATSLVRSGPSLIWHPDAGTFVHSGHNSNTDCWATVLPNGATDAASDLAVRYFDGDPADGAELTGKEVAGVRDLGLTWRSPQGNVTGAALLSDHSITRRLTIVGEATEQVPLVLRANDQLVWIGSGPVRIGSTVTASGLRLRRGRVTLDIRWEKPLQASVTALDRTYFADARAQAHVLRVAHPPTAVFHYRLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NIH0</accession>
    <name>A0A0F7NIH0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ferredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_27445</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_27445"/>
    <dbReference type="EnsemblBacteria" id="AKH87063">
        <property type="protein sequence ID" value="AKH87063"/>
        <property type="gene ID" value="AA958_27445"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_27445"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5783"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007419">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041854">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017224">
        <property type="entry name" value="Opine_Oxase_asu/HCN_bsu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04324">
        <property type="entry name" value="Fer2_BFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037495">
        <property type="entry name" value="Opine_OX_OoxA/HcnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="2">
        <location>
            <begin position="1"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="Fer2_BFD" evidence="1">
        <location>
            <begin position="350"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH87063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="434" mass="44229" checksum="91BA0088DED455C9" modified="2015-07-22" version="1">MAAARAAARHGVRVLLVDSGAALGGQYHRQNSLAGRDRFALPPGVGHLPHTVVWALEPVPEGGHRVHLHTGPADGPGRTARSVATRALVLATGAYDRALPFPGWDLPGVYTAGAAQALAKGQGVRVGERVLVAGTGPFLLPVAASLTAAGAGVAGVLEAAEPVTAWLRRPADAVAGWRKSGELAGYGALLARHRIPYRRRTAVVAAHGTDRVEAVTTARLTSGWEIVPGSERRVEADAVCVGFGFVPQVETALAAGCALDGGFVAVDAAQATSVPGVFAAGELTGVGGAGPAAAEGEVAGVAAAKLLGARPAPPAAALRRVRAGRGFAAALARAYPVPDGWRTWLADDTLVCRCEEVPYGELRRAVREREALGVRAVKLVSRAGLGQCQGRVCGPNVACLTGLADAAAFARRPIASPVRLGELAEPPADPEPGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NIK4</accession>
    <name>A0A0F7NIK4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nitrate reductase (quinone)</fullName>
            <ecNumber evidence="7">1.7.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">AA958_29030</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a quinol + nitrate = a quinone + H2O + nitrite</text>
            <dbReference type="Rhea" id="RHEA:56144"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16301"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.7.5.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mo-bis(molybdopterin guanine dinucleotide)</name>
            <dbReference type="ChEBI" id="CHEBI:60539"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.7.5.1" evidence="7"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_027752281.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_29030"/>
    <dbReference type="EnsemblBacteria" id="AKH87098">
        <property type="protein sequence ID" value="AKH87098"/>
        <property type="gene ID" value="AA958_29030"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_29030"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6116"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009325">
        <property type="term" value="C:nitrate reductase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008940">
        <property type="term" value="F:nitrate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042126">
        <property type="term" value="P:nitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02776">
        <property type="entry name" value="MopB_CT_Nitrate-R-NarG-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037943">
        <property type="entry name" value="MopB_CT_Nitrate-R-NarG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006657">
        <property type="entry name" value="MoPterin_dinucl-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006655">
        <property type="entry name" value="Mopterin_OxRdtase_prok_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027467">
        <property type="entry name" value="MopterinOxRdtase_cofactor_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006468">
        <property type="entry name" value="NarG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01568">
        <property type="entry name" value="Molydop_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00926">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01580">
        <property type="entry name" value="narG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51669">
        <property type="entry name" value="4FE4S_MOW_BIS_MGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00551">
        <property type="entry name" value="MOLYBDOPTERIN_PROK_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00490">
        <property type="entry name" value="MOLYBDOPTERIN_PROK_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 12" id="KW-0408">Iron</keyword>
    <keyword evidence="11 12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S Mo/W bis-MGD-type" evidence="13">
        <location>
            <begin position="47"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00010312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AKH87098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="1225" mass="134879" checksum="E5285CB6EEA64DA1" modified="2015-07-22" version="1">MDGELAVALVRARRFFTRARVSDDLRVLHKSGGRAADEFYRDRWSHDKVVRSTHGVNCTGSCSWKVYVKDGIITWEAQQTDYPSVGPDRPEYEPRGCPRGAAFSWYTYSPTRVRYPYVRGVLLEMYREARKRLGDPVAAWADIVSDPERARRYKAARGRGGLVRASWDEAVEMVAAAHVHTIKEYGPDRLAGFSPIPAMSMVSHAAGARFYSLLGGVMLSFYDWYADLPVASPQVFGDQTDVPESGDWWDAGYLIMWGSNLPVTRTPDAHWMAEARYRGQKVVAVAPDYADNVKFADEWLAAQPGTDGALAMAMGHVILKEFFADRRTPYFEDYVKRYTDLPFLVTLEEGEADTYAPGKFLTAADLGGRAAAAEHAEFRTVLLDAATGEPVVPNGTLGDRFSESGAGKWNLDLGDVDPLLSSVGGGEEPVAVELPRFDAPDGGAGRLRRGVPVRRVAGRLVTTVFDLLLAQYGVAREGLPGCWPSSYDDASEPCTPAWQAAITGVDAEKAARIAREFAANAEESRGRSMIVMGAGTNHWFHSDTIYRAFLTLTTLTGCQGVNGGGWAHYVGQEKVRPITGYSALATAADWNRPARQMIQTAYWYLHTDQFRYDPFSADTLAAAGAGGPFAGKSTADVIAASARMGWMPSYPTFDRNPLALADEAEQAGRDVGEHVVGELRAGRLRFAAEDPDAPANFPRVLTVWRANLLGSSAKGNEYFLKHLLGTDSSVRACEAPPGARPRDVVWRDEAPAGKLDLLLTLDFRMTSTTVFSDVVLPAATWYEKHDLSSTDMHPFVHAFNPAIAPPWQTRTDWDAFNALAQAFSRLAADRLGTRRDVVAAPLLHDTPDELATPHGRVRDWKAGDCEPVPGRTMPKLITVERDYGAVAEKMTALGPLLDTLGASTKGVTLRLERELEYLRHKNGTVRGGVSDGRPSIARDVHACEAILALSGTTNGHLATQGFRTLEARTGTRLADLAAEHEGKRITFADTQAGPVPVITSPEWSGSETGGRRYSPFTVNVERLKPWHTLTGRQHFYLDHDWIAALGEQLPVYRPPLNMDRLFGEPRIGDVGELGVTVRYLTPHNKWSIHSEYQDNLLMLSLSRGGPVIWMSTTDAAKIEVRDNDWIEAVNRNGVVAARAIVSHRMPEGTVYMHHAQDRLIDVPRTETTGRRGGIHNSLTRLLIKPTHLIGGYAQLSYAFNYLGPTGNQRDEVTVIRRRANQEVTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NIK5</accession>
    <name>A0A0F7NIK5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_08005</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AKH86602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86602">
        <property type="protein sequence ID" value="AKH86602"/>
        <property type="gene ID" value="AA958_08005"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_08005"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1688"/>
    <dbReference type="OrthoDB" id="2217545at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="27"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH86602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="99" mass="10303" checksum="65E409D2AEFC3E4B" modified="2015-07-22" version="1">MVPLFVGWVVTAAGAFGVDAEGTTVTAGVTALVTAVYYAVFRALEEWAAKRDWKPLRLVAGVLLGWARPPEYPARASGARQSAAPVAAVPPPDAEGRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-12-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NIV8</accession>
    <name>A0A0F7NIV8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_13930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86747">
        <property type="protein sequence ID" value="AKH86747"/>
        <property type="gene ID" value="AA958_13930"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_13930"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2932"/>
    <dbReference type="OrthoDB" id="1538300at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="147" mass="16758" checksum="B8E52FDF6603843A" modified="2015-07-22" version="1">MAEEDLEVFFAHEHDPENVRRSHFPPRERERFMTHWRERILGDPTGLVQTVEVDGKVAGGVVAWWDGDRRFLGYVFGREFWGRGIGTRAVAAFLELERNRPLHADPYVGNEGSVRLLKRLGFQQTGSEWNGEDEHVMLVLGEAGAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A097H0Y4</accession>
    <name>A0A097H0Y4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Putative MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">cnq745</name>
        <name evidence="8" type="ORF">AA958_30705</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="ChemBioChem" volume="15" first="2385" last="2392">
            <title>A Membrane-Bound Prenyltransferase Catalyzes the O-Prenylation of 1,6-Dihydroxyphenazine in the Marine Bacterium Streptomyces sp. CNQ-509.</title>
            <authorList>
                <person name="Zeyhle P."/>
                <person name="Bauer J.S."/>
                <person name="Steimle M."/>
                <person name="Leipoldt F."/>
                <person name="Rosch M."/>
                <person name="Kalinowski J."/>
                <person name="Gross H."/>
                <person name="Heide L."/>
            </authorList>
            <dbReference type="PubMed" id="25224759"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CNQ-509</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KJ451627">
        <property type="protein sequence ID" value="AIT42133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019089.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH85861">
        <property type="protein sequence ID" value="AKH85861"/>
        <property type="gene ID" value="AA958_30705"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_30705"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6489"/>
    <dbReference type="OrthoDB" id="961781at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="190"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="303"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="341"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="370"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="393"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="432"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="463"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="53"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIT42133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH85861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="515" mass="54769" checksum="908067B699136B72" modified="2015-01-07" version="1">MDAEAQDNDGSTARDPAARRRHPLLFRVAQAKLRPRWRLSEITVTEEPEIRRAVRAAALGNAMEWFDYGIYAYLAVTLGDVFYSGASEGTRTILSLATFAVSFAVRPLGGAFFGPLGDRVGRKQVLALTMILMASATFSIGLIPSYDTIGLWAPLLLIIARLAQGFSTGGEYGGAATFIAEYAPDKRRGYYGSFLEMGTLAGYIGASGLVLVLTAGIGEDGMASWGWRIPFLIGGPLGAIGLYLRLRLEETPAFVKSEAGRATVAEVTGEAEPALGRKAEGGRAEGKQTPGELRRIMAGQRQTMMLCIALVAAYNVANYMLLTYMPTYLTEILDWPRAEQLAVVIATMVAMISVVTLVGRANDRIGRKPLLMIGMAGFFVVSAPAYILVREGAVLAVFGGMLLLGACLICLQGTMSATLPALFPTEVRYGSLAIGYNLSVAVFGGTTPAVIEGLVHVLDTPMAAAYYTMAFAVVGIVSVSLLTETAGLPLEGSPPAVATAAEAEEVVRTQRRNPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MYU5</accession>
    <name>A0A0F7MYU5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">Argininosuccinate synthase</fullName>
            <ecNumber evidence="2 9">6.3.4.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Citrulline--aspartate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">argG</name>
        <name evidence="10" type="ORF">AA958_03590</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + L-aspartate + L-citrulline = 2-(N(omega)-L-arginino)succinate + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10932"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57472"/>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.4.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 2/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the argininosuccinate synthase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.5" evidence="2 9"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014778.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_03590"/>
    <dbReference type="EnsemblBacteria" id="AKH81420">
        <property type="protein sequence ID" value="AKH81420"/>
        <property type="gene ID" value="AA958_03590"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_03590"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.756"/>
    <dbReference type="OrthoDB" id="357142at2"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00113"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004055">
        <property type="term" value="F:argininosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01999">
        <property type="entry name" value="Argininosuccinate_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00005">
        <property type="entry name" value="Arg_succ_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001518">
        <property type="entry name" value="Arginosuc_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018223">
        <property type="entry name" value="Arginosuc_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023434">
        <property type="entry name" value="Arginosuc_synth_type_1_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024074">
        <property type="entry name" value="AS_cat/multimer_dom_body"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11587">
        <property type="entry name" value="PTHR11587"/>
        <property type="match status" value="1"/>
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            <dbReference type="Proteomes" id="UP000034283"/>
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    <sequence length="398" mass="43163" checksum="AAA42C1A6CB6FC6C" modified="2015-07-22" version="1">MTERVVLAYSGGLDTSVAIGWIAAETGAEVIAVAVDVGQGGEDLDVIRKRALACGAVEAEVADAREEFADEYCLPAIKANALYMDRYPLVSALSRPTIVKHLVAAAQKHGAGTVAHGCTGKGNDQVRFEAGISSLAPGLKCIAPVRDYAMTRDKAIAFCEEKGLPIATTKKSPYSIDQNVFGRAVETGFLEDIWNAPIEDVYEYTQNPAVAREADEVVIAFERGVPVALDGRPVTVLQAVQQLNERAGAQGVGRIDMVEDRLVGIKSREVYEAPGAIALITAHQELENVTVERELARYKRQVEQRWGELVYDGLWFSPLKRALDGFIQEANEHVTGEIRMTLHGGRAVVTGRRSPASLYDFNLATYDTGDTFDQSMSKGFIEIFGLSSKIAAGRDLAR</sequence>
</entry>
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            <authorList>
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                <person name="Kalinowski J."/>
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                <person name="Kaysser L."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4 5">CNQ-509</strain>
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</entry>
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                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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    </evidence>
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        </source>
    </evidence>
    <sequence length="320" mass="31817" checksum="4261FDB115E42144" modified="2015-07-22" version="1">MAAAAVTVVLWASAFVSIRDTGEHFSPGALALGRLLAGSAALALLLLVRREGLPPRGAWPGIAVSGTLWFGVYMVALNWGEQLVDAGTAAMVVNVGPMLVALLSGWLLKEGFPRMLLAGLGVSFAGAVVVGISMSDGGSSSLGGVLLCLLAAATYASGVVSQKPALAHASPLQVTAYGCMTGAVLCLPFAGQLAGQIGDAPLSATANVVYLGIFPTALAFTTWAYALARTTAGKMGATTYAVPALVVLMSWAALGEVPEVPTLLGGALCLAGVAVSRRRGVRRDPRVVASGGTAAGTPAAGAAPAAGEPAGGPAPEEKPC</sequence>
</entry>
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    <accession>A0A0F7N011</accession>
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    </gene>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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        <property type="gene ID" value="AA958_02875"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="project" value="UniProt"/>
    </dbReference>
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        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
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        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
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        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
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        <property type="entry name" value="TetR_C_16"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="11"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH81291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="198" mass="21368" checksum="8786688E05E918F8" modified="2015-07-22" version="1">MRPLGPRPGRPDTRADIIRAAKRMFARGYGACSLRAVAREAGVDPSLLVQFFGSKEGLYLAAIADVMRPDDVLGRIIGDASDGLGGRLAAYYFDLWDDAETRWPFQAILLSAASYQPAAAILRDFITRELVARIASRAVKDRAELRAGLAGSHLVGTALVRYVVRFGPLAELPRPELAEIVGRTIDGYLFGPLPAAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N073</accession>
    <name>A0A0F7N073_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_06995</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015356.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_06995"/>
    <dbReference type="EnsemblBacteria" id="AKH82005">
        <property type="protein sequence ID" value="AKH82005"/>
        <property type="gene ID" value="AA958_06995"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_06995"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1463"/>
    <dbReference type="OrthoDB" id="1261526at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH82005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="321" mass="34961" checksum="B97F0C132DE6AEA8" modified="2015-07-22" version="1">MSEEQNRDKPVPHTADKPLRGKVALVAGATRGAGRAIAVALGTLGATVYATGRTTREHVSEVGRTTETIEETAELATAAGGEGVAVRVDHLEADQVRDLVARIERDHGRLDVLVNDVWGGEHLVEFGKKMWEIDLDRGLRMMELGVKTHLITSHCALPLLLRTGGGLVVEITDGTAEANKPYREMFFYDLTKNAPIRMAFGLSHELKEAGATALSLTPGFLRSEQMLDHFGVTEENWRDAIAKDKHFALSESPVLVGRAVAALAADPDKARWNGASLYSGQVAKEYGFTDTDGTLPDSWPYFQRAMAGEDPGDPESYRLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0Y4</accession>
    <name>A0A0F7N0Y4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Photosystem reaction center subunit H</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_01530</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_01530"/>
    <dbReference type="EnsemblBacteria" id="AKH81063">
        <property type="protein sequence ID" value="AKH81063"/>
        <property type="gene ID" value="AA958_01530"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_01530"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.337"/>
    <dbReference type="OrthoDB" id="1849143at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030077">
        <property type="term" value="C:plasma membrane light-harvesting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045156">
        <property type="term" value="F:electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019684">
        <property type="term" value="P:photosynthesis, light reaction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014747">
        <property type="entry name" value="Bac_photo_RC_H_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027275">
        <property type="entry name" value="PRC-brl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011033">
        <property type="entry name" value="PRC_barrel-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05239">
        <property type="entry name" value="PRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50346">
        <property type="entry name" value="SSF50346"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRC" evidence="2">
        <location>
            <begin position="12"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH81063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="132" mass="14533" checksum="7F41E85DE406634B" modified="2015-07-22" version="1">MGGTVQTDIDPRSLIGVRAYDSNGDKLGTVDEVYLDDATGAPQWAALRTGLFHRDAFVPLGPSELADEGLRVPYERELIKDAPDFGVGRHLSPEQELQLYHHYGMTLPPEVAKTRPQQPQDRDFGEVAGSDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N1I0</accession>
    <name>A0A0F7N1I0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ribonuclease E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_09545</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015774.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_09545"/>
    <dbReference type="EnsemblBacteria" id="AKH82430">
        <property type="protein sequence ID" value="AKH82430"/>
        <property type="gene ID" value="AA958_09545"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_09545"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2012"/>
    <dbReference type="OrthoDB" id="1209444at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019307">
        <property type="entry name" value="RNA-bd_AU-1/RNase_E/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004659">
        <property type="entry name" value="RNase_E/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30001">
        <property type="entry name" value="PTHR30001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10150">
        <property type="entry name" value="RNase_E_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00757">
        <property type="entry name" value="RNaseEG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="S1 motif" evidence="7">
        <location>
            <begin position="834"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1212"/>
            <end position="1412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="34"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="209"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="343"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="393"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="538"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="606"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="672"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="721"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="759"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1218"/>
            <end position="1241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1262"/>
            <end position="1281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1342"/>
            <end position="1370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1398"/>
            <end position="1412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH82430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="1412" mass="147338" checksum="F5031A79B8B87103" modified="2015-07-22" version="1">MLEPIEPSEAQSPSAGITGDGGAAVGGPLDTPSDRLPFRRRRAAEPAGEVPRRATEPTTGEPGPALTYEPAGEPAGTPVPVLAEPAVDVAEAAGSPAAVDREITAGTAAAEPGSGTAAAPPARRSRRRVVRDAGTPEAAAPDTVVVPVGEQPGSAASGHTVPVSGQEPAAEAGPPRRRRFVRSAGTPQAAAAAEPVPQPAAAGDATTTDHHDSTNEGAHTVADNETEAEGADSSADSGTRRRRRRVTRTVATPAAGTEAAVQPAAPEQAGEAAPQAAAEATEAGTGPAAESRPEPDADAAPKGRKRRRVVRSAGTPEAAEPAVAEPAADAAQAAPAETPAADEEPAPRTRRVRRRKTDAESAGTAETADGAAPGDQTPAAPPAAPAAEDAAEPAAGTRRRRSRRVTAPAGEPTHVESAAEAPAPAADSAPAVAETETAAAAGPAAGPAATGRRRTRRATAPAGEPAAEAGAAAEQAADETPADSGTSRRRTRRATGAAAGEAADADAAPRRRTRRAAAAAEEPVTGDRPAPAEAAAEPDSAPRRRTRRAPAATEPAVDDTAGQFSDGGEQPPGFGAAPLALFQAPVFTEPAFQTPQRAAAEAAVGPEEAEEPEDADEIEAGAEAATEAQGEAEEAAAEDRDEQDEDGEDRGRRRRRRGGRRRRRGEGAEDGDRGDEAAEDGEEAREADAEAAEGEAGEGERARGGSSSTSSRRRRRRRRRTEGADGAEGAPDDPERTVVKVREPRAKAEPSDEVQSIKGSTRLEAKKQRRREGREQGRRRVPIITEAEFLARREAVERVMVVRQQGDRTQIGVLEDNVLVEHYVNKEQSASYVGNVYLGKVQNVLPSMEAAFVDIGKGRNAVLYAGEVNFEALGLANSPRRIEHALKSGQSVLVQVTKDPIGHKGARLTSQVSLPGRYLVYVPEGSMTGISRKLPDTERARLKTILKKIVPEDAGVIVRTAAEGASEDELRRDVERLQKQWEDIRKKAKSGNAPTLLYGEPDMTVRVVRDIFNEDFSKVIVSGAKGWDTIHGYVSHVAPDLVERLSKWTSEVDVFATYRIDEQLMKALDRKVWLPSGGSLVIDRTEAMVVVDVNTGKFTGQGGNLEETVTRNNLEAAEEIVRQLRLRDLGGIIVIDFIDMVLESNRDLVLRRLLECLGRDRTKHQVAEVTSLGLVQMTRKRVGQGLLESFSEPCAHCNGRGVIVHMDQATAAGAGGGKRKKKGKEAREGKEAKEAAKDVKEVQAGGEAASVEAAPAEPAAEPAEAERPEAGEPAEAVRPARSRRRVTRKAMSPGGPPQAAEPAGAESEAAPAVEPAEAPVAPAEAPEAAAAETEAAEKPRTRKKTAAKRASAKKATAKKAAAKKTAKTTAKKAATKSAATKTAAKATAKKSVKKTAAAEQGSPPSVSVTTED</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N1J0</accession>
    <name>A0A0F7N1J0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Rod shape-determining protein MreD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AA958_09600</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MreD family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015784.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_09600"/>
    <dbReference type="EnsemblBacteria" id="AKH82440">
        <property type="protein sequence ID" value="AKH82440"/>
        <property type="gene ID" value="AA958_09600"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_09600"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2023"/>
    <dbReference type="OrthoDB" id="2037083at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007227">
        <property type="entry name" value="Cell_shape_determining_MreD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04093">
        <property type="entry name" value="MreD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03426">
        <property type="entry name" value="shape_MreD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0133">Cell shape</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519031" evidence="9">
        <location>
            <begin position="27"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="75"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="104"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AKH82440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="239" mass="24357" checksum="BD11D15B1D698A2E" modified="2015-07-22" version="1">MRHVNRVLLCASLLVTALVFQVTVLARLHLPGAVPDLTLLVVLALAMVYGHVGGALVGFTAGLLADIAPPADHAVGRYALVLAVIGYLAGLIKPETGQVRTAAGPMMVVGCAAVGSTLLYAGVGALVGEGSVRGVGLGSLVFTAAIYDLLLAPFTVPLVMALARKADRDTTAEAAETATGGSAAGDSSYRWLAGGTVSRTAVKRARSYGRGGIGRQRGNLFGPKSKAAKATRIKGVKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N1R7</accession>
    <name>A0A0F7N1R7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Methylmalonate-semialdehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_10190</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015877.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_10190"/>
    <dbReference type="EnsemblBacteria" id="AKH82535">
        <property type="protein sequence ID" value="AKH82535"/>
        <property type="gene ID" value="AA958_10190"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_10190"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2146"/>
    <dbReference type="OrthoDB" id="490746at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004491">
        <property type="term" value="F:methylmalonate-semialdehyde dehydrogenase (acylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07085">
        <property type="entry name" value="ALDH_F6_MMSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010061">
        <property type="entry name" value="MeMal-semiAld_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43866">
        <property type="entry name" value="PTHR43866"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01722">
        <property type="entry name" value="MMSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="3">
        <location>
            <begin position="16"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH82535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="497" mass="52187" checksum="BE6532D1BAC56D28" modified="2015-07-22" version="1">MKTIGHWIGGKAVEGASGRSGPVYDPATGAQAAEVAFASAAEVDAAVAAAREAFAEWGGSSLARRTAVLFRFRELLAARREDVARLITAEHGKVHSDALGEVARGLEIVEVACGIPQLLKGELSTQVSTRIDVASIRQPVGVVAGITPFNFPAMVPMWMFPLAIACGNTFVLKPSEKDPSASGLLAELLAEAGLPEGVFNVVHGDKEAVDRLLEHPDVAALSFVGSTPIARYVFTTGTSHGKRVQALGGAKNHMLVLPDADLDAAADAAVSAAYGSAGERCMAVSAVVAVGDTGDELVTKIAERARKVRIGPGDDPDSEMGPLITREHRDKVAGYVRGAAAQGAEVVVDGTGYTVPGREGGHWIGVSLLDRVPVESDAYRDEIFGPVLCVVRAETYEEGVRLVNGSPWGNGTAIFTRDGGAARRFQLESTAGMVGVNVPIPVPVGYHSFGGWKDSLFGDHHIYGEDGVRFYTRAKVVTTRWPDPADGGVDLGFPTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N1U1</accession>
    <name>A0A0F7N1U1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8 9">Chorismate synthase</fullName>
            <shortName evidence="8">CS</shortName>
            <ecNumber evidence="4 8 9">4.2.3.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">5-enolpyruvylshikimate-3-phosphate phospholyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">aroC</name>
        <name evidence="11" type="ORF">AA958_03195</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 9">
            <text>5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21020"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57701"/>
            <dbReference type="EC" id="4.2.3.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8 9">
            <name>FMNH2</name>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
        </cofactor>
        <text evidence="8 9">Reduced FMN (FMNH(2)).</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8 9">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8 9">Belongs to the chorismate synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.5" evidence="4 8 9"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014708.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_03195"/>
    <dbReference type="EnsemblBacteria" id="AKH81349">
        <property type="protein sequence ID" value="AKH81349"/>
        <property type="gene ID" value="AA958_03195"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_03195"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.681"/>
    <dbReference type="OrthoDB" id="981870at2"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004107">
        <property type="term" value="F:chorismate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07304">
        <property type="entry name" value="Chorismate_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00300">
        <property type="entry name" value="Chorismate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000453">
        <property type="entry name" value="Chorismate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035904">
        <property type="entry name" value="Chorismate_synth_AroC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020541">
        <property type="entry name" value="Chorismate_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21085">
        <property type="entry name" value="PTHR21085"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01264">
        <property type="entry name" value="Chorismate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001456">
        <property type="entry name" value="Chorismate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103263">
        <property type="entry name" value="SSF103263"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00033">
        <property type="entry name" value="aroC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00787">
        <property type="entry name" value="CHORISMATE_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00788">
        <property type="entry name" value="CHORISMATE_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00789">
        <property type="entry name" value="CHORISMATE_SYNTHASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 8 9" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0288">FMN</keyword>
    <keyword evidence="7 8 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0521">NADP</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="282"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="137"/>
            <end position="139"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="258"/>
            <end position="259"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
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        <location>
            <position position="302"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="317"/>
            <end position="321"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="343"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00300"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU000605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AKH81349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="394" mass="41155" checksum="F75FC7BE996CF0D9" modified="2015-07-22" version="1">MSRLRWLTAGESHGPALVATLEGLPAGVPVTTDLVADHLARRRLGYGRGARMKFERDEVTFIGGVRHGLTLGSPVAVMIGNTEWPKWEKVMAADPVDPAELAGIARNAPLTRPRPGHADLAGMQKYGFDEARPVLERASARETAARVALGAVARSYLKETAGIEVVSHVVELGGARAPYGSVPTPADVARLDADPVRCLDADASKAMVEVIDQAHKDGDTLGGVVEVVAYDVPVGLGSHVHWDRRLDSRLAGALMGIQAIKGVELGDGFALARVPGSQAHDEIVGTDDGIRRSSGRSGGTEGGLSTGELLRVRAAMKPIATVPRALATVDVASGAATKAHHQRSDVCAVPAAGIVAEAMVALVLADAVAEKFGGDSVTETARNVRGYLENLAIR</sequence>
</entry>
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        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
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        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="23"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH81604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="141" mass="15741" checksum="0DBF4DE1075E881F" modified="2015-07-22" version="1">MLMRTDPFRELDRLAQQLMGPGTWSRPSPMPMDAYRDGDEYVVAFDVPGVTADAIEIDVERNMLTVKAERRPAAKSGDVQMELSERPLGVFSRQIMLADTLDTEHIQADYDAGVLTLRIPIAERAKPRKITIGSGRKEIPG</sequence>
</entry>
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                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
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    <dbReference type="EnsemblBacteria" id="AKH81187">
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="8"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18029"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="117" mass="13473" checksum="009A7B7F298AC373" modified="2015-07-22" version="1">MPARFKDLALDARDHQALADWWCTALGYARRQESGEEWPAEWPVPIHDPAGRGPLIWINPVPEAKTVKNRIHLDVWGVPEEMEALGATLVRRRDDEIDWTVIADPEGNEFCVFEEER</sequence>
</entry>
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    <accession>A0A0F7N302</accession>
    <name>A0A0F7N302_9ACTN</name>
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        <recommendedName>
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    </protein>
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    </gene>
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        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AKH81769">
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    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_05650"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1183"/>
    <dbReference type="OrthoDB" id="1589192at2"/>
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    </dbReference>
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        <location>
            <begin position="6"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="327" mass="32010" checksum="667151FB1C3E1335" modified="2015-07-22" version="1">MEKLVIGIDVGGTRIRAALARSAGGGVLRTASAGAGNPRSVPPEVLASRLAACVAPLAAAEAPGTGRIAAVVAGVAGAEPRNPDDAGTRVAHAALRTALRRGGVRPVPLQIRGDTEIAFAAGPDAPSEGVVAIAGTGACAARITGRRQTATIDGHGWLLGDEGSGFWIARQALRAALRSLDGRGPATSLAGLLTAATGGGEPGERGAGAEAPGRAAAGPVVRIALVDAGFAGAPVEIARLCPVVVRAAAAGDAVAGAILDEAADHLAETVAVLAPAPGEPLVTTGALLAPAGPLLPRFTARMRPYDVTPAPVPDGLAGAVALARTML</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N304</accession>
    <name>A0A0F7N304_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SBP_bac_5 domain-containing protein</fullName>
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    </gene>
    <organism evidence="3 4">
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        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Leipoldt F."/>
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                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_02575"/>
    <dbReference type="EnsemblBacteria" id="AKH81242">
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        <property type="gene ID" value="AA958_02575"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_02575"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.551"/>
    <dbReference type="OrthoDB" id="162819at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519190" description="SBP_bac_5 domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="2">
        <location>
            <begin position="78"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH81242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="531" mass="56699" checksum="94D1F17A07B7D534" modified="2015-07-22" version="1">MSVRGIRAAVSVTAAAAVLAGAAACSNPDADDGSGGDGATAVIGVANEPDTLSPLLGYGKDGNSKIFDGLLARDGDMELKPALARALPEITDGGTTYTYELRDDVTFSDGEPFTAADVVFTYETILDPGTNNASKGDLEAVESVEAKGDGTVVFTLKYPYAPFAERTVLPIAPEHVAGKGDVNTGAFNTEPIGTGPYVLDDWRKGEKLTFSANPGYWGGRPKVKKLTMAIIADDDIRATRLRSGDLDGAILPPNLAKTFAEDDDKQTLAATTADHRAVTLPTDNPVTGDIAVRRALDVAVDRGAMVDKLLEGRGKAAYGPVPTGSEWFAKGTERPYDTGLAGKILDDAGWRAEDGGIREKDGQRASFTLYYPSGDKVRQEHALAFAGDAKKVGIEARVESGTWEVIEPRMGEDAVLAGGGSPADPDFDLYPMLYSELAGQGFNNMASYENQDVDTALVEGRESPDKAERKRAYDKVQQELTENPGYVFLTHIDHIYVVADTWRGLTTQVEPHEHGFGSGPWWNVESWQPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N315</accession>
    <name>A0A0F7N315_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_13240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016367.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_13240"/>
    <dbReference type="EnsemblBacteria" id="AKH83035">
        <property type="protein sequence ID" value="AKH83035"/>
        <property type="gene ID" value="AA958_13240"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_13240"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2786"/>
    <dbReference type="OrthoDB" id="1587945at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="308"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="346"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="387"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH83035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="413" mass="43383" checksum="BD3C4FC93A2859C1" modified="2015-07-22" version="1">MGIESDQLVYDYLSRVGDIAQQRALPSGQRMRLVNELRASIDKVRAAEGAHSVSAVKQVLARFGSPGDIVEAAKRDPASAVPEVAVQPGEPPGGGGGLASRLPRPRVGGSERWLGRLPRPRAGGGEAGGSPGGREPERAAPEVPGTAPGDFTPPAEPPPTAAAPPHLAGEDELDPTHADPDWWRVEPAPFAGPMPGAGSGADNVPGFTGGIELPELFQRPDQQDGDEEEKGAQKGGGTGAMGRAARAAKAAREANAARAARAAKAKQARREAAEAGEEEAYEDEEPSSPSRRSAATRELLRSAGLMEVLAMGALLGGAALDQWMASVVGWALVYTSRRLSMTEKKWAALGVPGTVGAAGLVWLWGRAQERWGEPLKEGTLGQEFSDMLPTLVRLAAVASTLFLLWRARRRLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-12-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N330</accession>
    <name>A0A0F7N330_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AA958_02735</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014630.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH81267">
        <property type="protein sequence ID" value="AKH81267"/>
        <property type="gene ID" value="AA958_02735"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_02735"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.584"/>
    <dbReference type="OrthoDB" id="149255at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004869">
        <property type="entry name" value="MMPL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03176">
        <property type="entry name" value="MMPL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519118" evidence="8">
        <location>
            <begin position="35"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="271"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="305"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="372"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="528"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="559"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="592"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="643"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="682"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="9">
        <location>
            <begin position="196"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="725"/>
            <end position="747"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AKH81267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="747" mass="77506" checksum="953028E0A1C3439C" modified="2015-07-22" version="1">MATFLYKLGRLAFRRRRITALIWLLLFGLAGAGAATAGTPPEDEFALPGTEAQQAFDLLEERFPGQSADGATARIVFEAPDGQKITATDNREAVDGVLDGIAGDQVESVSDPFADNAGVSKDGSTAYAVVDYKVTSMEIEDKTREALTDLGEKERDDGLTIEAGGDAVMAEPDMGNGEIIGIGIALVVLVITFGSLVAAGLPIITALIGVGIGISSITALATVFDLSATTSTLAMMIGLAVGIDYALFIASRYRAELTDGHSREEAAGRAVGTAGSAVVFAGLTVIIALAGLAVVNIPILTKMGLAAAGTVALAVLIALTLVPAALGIVGKRIYGKKVRKANPETGAPKASDHDAKPNMGTRWARGVLKRPVLVLAATVIGLGALAAPVASMELGLPDEGSQPTDTTQRKAYDMLSEAFGPGFNGPVTGVIDAGEAENPQQAADEAVARISDVDGVVSVTPAAFNEAGDTATVMVTPSTGPSDTDTKDLVHEIRDLASGLQDETGAELYLTGNTAVIIDFSQVLDDALVPYLALVVGLAFVLLMLVFRSVLVPLKAALGFLFSVLAALGAVVAVFQWGWLAGLLGVEETGPIMSMMPIFLIGVVFGLAMDYEVFLVSRMREAYVHGESAGDAVVTGFRYGARVVTAAAVIMISVFAGFIGAGDSMIKMMGFGLAVAVLFDAFLVRMTIVPAVLALIGTSAWWLPKWLDRILPNVDVEGEKLYRQLAAAPAPPPTAGEERAPEPTGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N364</accession>
    <name>A0A0F7N364_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DAGKc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_02910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014660.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_02910"/>
    <dbReference type="EnsemblBacteria" id="AKH81297">
        <property type="protein sequence ID" value="AKH81297"/>
        <property type="gene ID" value="AA958_02910"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_02910"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.622"/>
    <dbReference type="OrthoDB" id="869726at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045540">
        <property type="entry name" value="YegS/DAGK_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19279">
        <property type="entry name" value="YegS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="SSF111331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAGKc" evidence="1">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="263" mass="26361" checksum="EA124D5C2FC2FBB5" modified="2015-07-22" version="1">MRRFTALVNPAAGRAAGAAALIPLARALRGAGAQVEAEYSRGFGHAAELAERAAGAGRTVLAVGGDGMAGTVAGALAESDAVCGLVPGAVGRNAVARALGLPRAAEELAELLLHGEPRPVDVLRVDGETRSFALGAVWIGAGAARTAPGRALASRRSALFRITVDGTPYELRGHTAVLANAPCHGAPAAPGSGPGVLLDDGALDVAVLGGGPGRPTRTRGETLRGRRVRVEADRPMPYAADGIPASGVPLTAQVLPGALRVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N393</accession>
    <name>A0A0F7N393_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Coenzyme A biosynthesis bifunctional protein CoaBC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">DNA/pantothenate metabolism flavoprotein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Phosphopantothenoylcysteine synthetase/decarboxylase</fullName>
            <shortName evidence="3">PPCS-PPCDC</shortName>
        </alternativeName>
        <domain>
            <recommendedName>
                <fullName evidence="3">Phosphopantothenoylcysteine decarboxylase</fullName>
                <shortName evidence="3">PPC decarboxylase</shortName>
                <shortName evidence="3">PPC-DC</shortName>
                <ecNumber evidence="3">4.1.1.36</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="3">CoaC</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="3">Phosphopantothenate--cysteine ligase</fullName>
                <ecNumber evidence="3">6.3.2.5</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="3">CoaB</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="3">Phosphopantothenoylcysteine synthetase</fullName>
                <shortName evidence="3">PPC synthetase</shortName>
                <shortName evidence="3">PPC-S</shortName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="3" type="primary">coaBC</name>
        <name evidence="7" type="ORF">AA958_03080</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.</text>
    </comment>
    <comment type="function">
        <text evidence="4">Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>(R)-4'-phosphopantothenate + CTP + L-cysteine = CMP + diphosphate + H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine</text>
            <dbReference type="Rhea" id="RHEA:19397"/>
            <dbReference type="ChEBI" id="CHEBI:10986"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:59458"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="6.3.2.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine = (R)-4'-phosphopantetheine + CO2</text>
            <dbReference type="Rhea" id="RHEA:16793"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:59458"/>
            <dbReference type="ChEBI" id="CHEBI:61723"/>
            <dbReference type="EC" id="4.1.1.36"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="3">Binds 1 FMN per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 2/5.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">In the C-terminal section; belongs to the PPC synthetase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.36" evidence="3"/>
    <dbReference type="EC" id="6.3.2.5" evidence="3"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014689.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_03080"/>
    <dbReference type="EnsemblBacteria" id="AKH81327">
        <property type="protein sequence ID" value="AKH81327"/>
        <property type="gene ID" value="AA958_03080"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_03080"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.657"/>
    <dbReference type="OrthoDB" id="1346419at2"/>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00353"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004632">
        <property type="term" value="F:phosphopantothenate--cysteine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004633">
        <property type="term" value="F:phosphopantothenoylcysteine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015941">
        <property type="term" value="P:pantothenate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02225">
        <property type="entry name" value="CoaBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035929">
        <property type="entry name" value="CoaB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005252">
        <property type="entry name" value="CoaBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007085">
        <property type="entry name" value="DNA/pantothenate-metab_flavo_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04127">
        <property type="entry name" value="DFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102645">
        <property type="entry name" value="SSF102645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="SSF52507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00521">
        <property type="entry name" value="coaBC_dfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3 4" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="3 4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 4" id="KW-0288">FMN</keyword>
    <keyword evidence="3 4" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 3 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavoprotein" evidence="5">
        <location>
            <begin position="12"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="DFP" evidence="6">
        <location>
            <begin position="194"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphopantothenoylcysteine decarboxylase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphopantothenate--cysteine ligase" evidence="3">
        <location>
            <begin position="199"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="315"/>
            <end position="318"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="335"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="349"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="353"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH81327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="409" mass="42261" checksum="4229B0E3AADB395D" modified="2015-07-22" version="1">MAEAAKEAAPAEVVLGVSGGIAAYKACELLRLLTESGHAVRAVPTAAALHFVGEATWAALSGRPAATQTWTDVHEVPHVRIGRRADLVVVAPATADVLAKAAHGLADDLLTNTLLTASCPVVFAPAMHTEMWEHPATRANVATLRARGAVVIEPAVGRLTGADTGKGRLPEPAEIFEVCRRALARGAGGLAPDLAGRHVVVSAGGTREPLDPVRFLGNRSSGRQGYALARTAVARGARVTLLAANTALPDPAGADIVRVGTTVELQEAVVKAAADADAVVMAAAVADFRPVTYATGKIKKKDDREPDPITLTRNPDILAGISAARPRPGQVVVGFAAETDDVLANGRAKLARKGCDLLVVNEVGETKAFGSDGNEAVVLTADGHEVPVPFGPKEALADVVWDLVAERFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N398</accession>
    <name>A0A0F7N398_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_13800</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016459.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH83130">
        <property type="protein sequence ID" value="AKH83130"/>
        <property type="gene ID" value="AA958_13800"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_13800"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2906"/>
    <dbReference type="OrthoDB" id="1926714at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043215">
        <property type="term" value="P:daunorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900753">
        <property type="term" value="P:doxorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005894">
        <property type="entry name" value="DrrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01188">
        <property type="entry name" value="drrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="4"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="313"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="313"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH83130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="360" mass="38203" checksum="AD0CBA8EB2A43DF0" modified="2015-07-22" version="1">MTAILAEGLRKTYGKKGAAKAALVGLDLAVPAGTVHAVLGPNGAGKTTAVRILATLLRPDGGTVRVAGHDPVREPDEVRYRIGLLGQHAAVDEVLSGRQNLELFGRLYHLGRAGARRRAAELLARFGLDGTGDKPVGQYSGGMRRRLDLAASLLMRPQVLFLDEPTTGLDPRGRTEVWQAVRSLVGDGTTVLLTTQYLEEADQLADRVSVVDHGRAVAEGTADELKARLGGDRIDVVVRDADRLTAAAAVIGMAARAEEDDIEVDADARRISAPVADRMAALAETVRGLGAAGVAAEDVSLRRPTLDEVFLHLTGRRPEQDRKPDKDRDREPGRDREPGRDRADGGAAGPAGTVAEGRTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3D4</accession>
    <name>A0A0F7N3D4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_06100</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015201.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_06100"/>
    <dbReference type="EnsemblBacteria" id="AKH81848">
        <property type="protein sequence ID" value="AKH81848"/>
        <property type="gene ID" value="AA958_06100"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_06100"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="68"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="181"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="238"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="69"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH81848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="275" mass="30238" checksum="EF9FAFD7C6CA4D31" modified="2015-07-22" version="1">MKRTSIGSRIGLPAAVAGLLIFTLFPVYWMMSTALDPRASSRGSDLLPSGVTFEHFSRVWNEGDFDRYLLNSAIVGLGTILAAAALSLFAAVAVARFRFTFRTSVLIMILIVQMVPLEALVIPLFLQMRDYEMLNSLLGLTIVYIALSLPFAIWTLRGFVATVPKEVEEAAYIDGCTWPRMFWSVLLPLVAPGLVATSVFAFITAWNEFVFAYTFMKDSEKYTAAVGIYQFFGENDTAWGPVMASSTLITLPVLIFFVIVQRRLASGLAAGAIKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3J2</accession>
    <name>A0A0F7N3J2_9ACTN</name>
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        <submittedName>
            <fullName evidence="5">Methionine ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_10670</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_10670"/>
    <dbReference type="EnsemblBacteria" id="AKH82611">
        <property type="protein sequence ID" value="AKH82611"/>
        <property type="gene ID" value="AA958_10670"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_10670"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2244"/>
    <dbReference type="OrthoDB" id="1926714at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="47"/>
            <end position="54"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH82611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="312" mass="34921" checksum="CC3EF96AAAEF3A03" modified="2015-07-22" version="1">MIEVEDLEKVFVVRRRAGRLRRTRHEVRAVGGISFSVPRGEMVGYIGPNGAGKSTTIKMLTGILTPSGGRLRVAGIDPARERTKLARRIGVVFGQRTTLWWDLPLLDSYRVMRRMYRIPGDRYRENLERCTELLGLGDLLEVPVRQLSLGQRMRGDIAAALLHDPEVLYLDEPTIGLDVLSKAKVREFLRELNAERGTTVLLTTHDLSDIEQLCKRVMVIDHGRLMYDGGLDGLHAVGESERMLVVDLERELPPIDLAGCRTVKVEGPRQWLAFPAGASAAPLVAEVAARWPLVDLSVREPDIEDVIARMYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3V3</accession>
    <name>A0A0F7N3V3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_07115</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_07115"/>
    <dbReference type="EnsemblBacteria" id="AKH82028">
        <property type="protein sequence ID" value="AKH82028"/>
        <property type="gene ID" value="AA958_07115"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_07115"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1491"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008305">
        <property type="term" value="C:integrin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013519">
        <property type="entry name" value="Int_alpha_beta-p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000413">
        <property type="entry name" value="Integrin_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01839">
        <property type="entry name" value="FG-GAP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01185">
        <property type="entry name" value="INTEGRINA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00191">
        <property type="entry name" value="Int_alpha"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="SSF69318"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51470">
        <property type="entry name" value="FG_GAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519151" evidence="5">
        <location>
            <begin position="29"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="199"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH82028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="479" mass="48314" checksum="89B04EF16019564A" modified="2015-07-22" version="1">MTRQPRRRALVALATSVALAGGGLTAVAAPPAAAAPSGLKGDFDGDGYRDVVIGNPAATVSGKTYAGAVAVLYGSAAGPDGSRRAVYHQGTAGVPGSPEEDDYFGETVAVDDFDRDGYADLLVGASRENVSGDVDRGTLTLLWGGPRGLSGGAAVRVAHVPGTGCNLAEGLYAGDFDGDGAPEISVAARCAAFHLRGPFTREGRPQSQRRDPLFGTTRGGAYGNVDADPQAERIVFVGLIDGRPGGTIYVDDWTGDGYARTLLTGAGGLTGEVGDVDGDGYGDLVTGYPDEPRNSGQPWAVGGTVQVWYGGPDGIDPAQRPQRIHQGTAGIPGGGEPDDRFGASVGVADTDADGRAEVAIGVPGEDFDGKSFAGTVTLLRGTANGLTGAGARLLHRNTAGVPGAAAKGDGFGDEVALGDRNRDGRADLTVGAPWRAAGGFVWHGRGTAGGITTTGSFNVTAARAGFGGEFPGFGEVIAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3Z0</accession>
    <name>A0A0F7N3Z0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Group 1 truncated hemoglobin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_07430</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
        <text evidence="4">Binds 1 heme group per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the truncated hemoglobin family. Group I subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015438.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_07430"/>
    <dbReference type="EnsemblBacteria" id="AKH82088">
        <property type="protein sequence ID" value="AKH82088"/>
        <property type="gene ID" value="AA958_07430"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_07430"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1557"/>
    <dbReference type="OrthoDB" id="1697277at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005344">
        <property type="term" value="F:oxygen carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001486">
        <property type="entry name" value="Hemoglobin_trunc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016339">
        <property type="entry name" value="Hemoglobin_trunc_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01152">
        <property type="entry name" value="Bac_globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002030">
        <property type="entry name" value="Globin_Protozoa/Cyanobacteria"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="SSF46458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="3 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0561">Oxygen transport</keyword>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="binding site" description="proximal binding residue" evidence="4">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR002030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR002030-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH82088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="118" mass="12659" checksum="6E93B43081A61C0C" modified="2015-07-22" version="1">MTIYDSIGGETAVATAVDNFYDRVLDDPELKPFFDGIDVQRLKRHQRAFIGAALGGPGGYNGRGMRKAHEGLGITPAHFERVVDHLTATLVGLGVPDETVKTIGATLEPLRADIAQEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N425</accession>
    <name>A0A0F7N425_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_07595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015469.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_07595"/>
    <dbReference type="EnsemblBacteria" id="AKH82119">
        <property type="protein sequence ID" value="AKH82119"/>
        <property type="gene ID" value="AA958_07595"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_07595"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1593"/>
    <dbReference type="OrthoDB" id="1755236at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="253"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="282" mass="29278" checksum="4B47BE46336BBCF2" modified="2015-07-22" version="1">MNIAVAVPSALLAALCFGIGSVLQHEAARQAPMHKSLRLRLLLDLARRPRWLAGLGLASSSFAFLWIALAFGPLALVLPLAATDLLFALPFLALRRGERLTRSEATGIICTAGGVAVFLTVLPLSPRTTAPGIRDWAPVLVAVVGVVALLAPMGSWRPGRLRAAAYAVCAASVLALLDSLTKSTAARFRTDGLETLVHWEPYGLITVGVAGLVLSQSAFQAGSLAISLPIIDTLEPIGAVAIGIAVFGEQLALTDWALTVQMLGAASAVTGIVLLGRSPLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4F1</accession>
    <name>A0A0F7N4F1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_05440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015086.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_05440"/>
    <dbReference type="EnsemblBacteria" id="AKH81732">
        <property type="protein sequence ID" value="AKH81732"/>
        <property type="gene ID" value="AA958_05440"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_05440"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1141"/>
    <dbReference type="OrthoDB" id="1515497at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="45"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="249" mass="27221" checksum="FFAB41AECCED7CB5" modified="2015-07-22" version="1">MLHSEIWDDQAAQSYDTPGTGMFAPEVLGPTVDRLVELAGGGRALEFAVGTGRVAVPLAERGVPVSGIELSEPMIDRLRAKADEAAIPVVVGDMATARVPGEFQLVYLVFNTISNLLTQAEQVACFRNAARHLAPGGRFVVELWVPELRKLTPGQQAVVWESTTGYIGLDTYDVLRQQVVSHHFRFDAGAGHEARLFRSPHRYVWPAELDLMAELAGMTLESRHADWAGGEFTAESRSHVSVYRTAGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4F5</accession>
    <name>A0A0F7N4F5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pyruvate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_16455</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016840.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_16455"/>
    <dbReference type="EnsemblBacteria" id="AKH83535">
        <property type="protein sequence ID" value="AKH83535"/>
        <property type="gene ID" value="AA958_16455"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_16455"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3463"/>
    <dbReference type="OrthoDB" id="1248201at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016624">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017596">
        <property type="entry name" value="PdhA/BkdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11516:SF41">
        <property type="entry name" value="PTHR11516:SF41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03181">
        <property type="entry name" value="PDH_E1_alph_x"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="E1_dh" evidence="4">
        <location>
            <begin position="64"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH83535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="381" mass="40835" checksum="1BAB86DBA676588C" modified="2015-07-22" version="1">MTVLEQPGRAYQPAPPPAWKPRTEAAPLLPDPEPYRVLGTSAAEKSDAGLLRELYGALVTGRRYNEQATTLTKQGRLAVYPSTTGQEACQVAAARALRPQDWLFPSYRDTLAAVARGLDPMQALTLLRGDWHTGYDPAEHRIAPLCTPLATQLPHAVGLARAAQLKGDDVVALAMVGDGGTSEGDFHEALNFAAVWRAPVVFLVQNNGFAISVPLAKQTAAPSLAHKAVGYGMPGRLVDGNDVVAAYEVLAEAVERARGGGGPTLVEAVTYRMDAHTNADDATRYRTDSEVEPWRAHDPIALLEAELAGRGLLDEAGAAAARAAAEELAAGMRERLHADAELDPMDLFAHVYTEPTPQLRAEESMLRAELEADLQAEEGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4G9</accession>
    <name>A0A0F7N4G9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_16540</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016855.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_16540"/>
    <dbReference type="EnsemblBacteria" id="AKH83550">
        <property type="protein sequence ID" value="AKH83550"/>
        <property type="gene ID" value="AA958_16540"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_16540"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3481"/>
    <dbReference type="OrthoDB" id="1345431at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
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            <begin position="20"/>
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            <begin position="59"/>
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            <begin position="91"/>
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            <end position="199"/>
        </location>
    </feature>
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        </location>
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            <begin position="299"/>
            <end position="320"/>
        </location>
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        <location>
            <begin position="326"/>
            <end position="347"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="359"/>
            <end position="385"/>
        </location>
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            <begin position="391"/>
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        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="24"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
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        <source>
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        <source>
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        <source>
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        </source>
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        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH83550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="437" mass="46013" checksum="54D24E60E1378ABF" modified="2015-07-22" version="1">MTAVREGGGRGLPGDPPGGLTAAAMWSLGVAVYFVAVTYRTSLGVAGIDAAERFDVGASALSGFSILQLLVYAGMQIPVGLLVDRLGTRRVLAMGIVLYTAGQFGFALSGTYGTALASRALLGCGDAMTFISILRLGARWFPARRGPLIAQLAGLVGMAGNLVSTLVISRMLQEFGWTPTFAGSAVAGAVMLVLVLLFLRDQPRDYVPPPPEGHHGRGIRAQIAGAWREPGTRLGFWVHFTTQFPAMVFLLLWGLPFLVEAQGASRAEAGQLLTLLVLSNMAVGLVYGQLVARHHAARLPLALGTVAATALVWGTVLSWPGAHAPGWLLVVLCCVLGACGPASMIGFDFARPANPPERLGTASGIVNMGGFTASITTLLAVGLLLDATGDRYGIAFASIFVLQILGITQMLRLRRRAHRRERERLVASRVSAVHVPA</sequence>
</entry>
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    <accession>A0A0F7N4Q2</accession>
    <name>A0A0F7N4Q2_9ACTN</name>
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        <name evidence="6" type="ORF">AA958_12910</name>
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        <name type="scientific">Streptomyces sp. CNQ-509</name>
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    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022679"/>
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    </evidence>
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    </evidence>
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            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
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            <dbReference type="Pfam" id="PF13439"/>
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            <dbReference type="EMBL" id="AKH82976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="426" mass="46779" checksum="4D314C562094C991" modified="2015-07-22" version="1">MRISFLLHNTYGIGGTIRTTFTLAQALAERHDVELVSVFRHRDEPMMEPPLGIPIRTLVDLRRRGPDYAGDLPDHRKPARVFPRGDGRHNQYSKLTDDRIGAYLRTVDADVVVGTRPGLNVHIARQTRRGPVRIAQEHLTLDGHGGRLRRELGIRYSLLDAVTTVTEADAHAYRTRLNLPGVRIEAVPNSVPAPAVAPADGTAKVVVAAGRLTRVKRYDLLIEAFAKVAAARPDWTLRIYGSGDRTGNERDALRAQIADLRLTEHVFLMGNASPMEREWVKGSIAAVTSSKESFGMTIVEAMRCALPVVSTDCPHGPSEIIEDGVDGRLVPVGNANAVADALLELIQDDALRRRTGAAARAASERFDPSRIAARHEAIFTELTERPRPRGLLRDLALRSRGTAYGSAYAARHVAATALRRARGRSR</sequence>
</entry>
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                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
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        <location>
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            <end position="28"/>
        </location>
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        <location>
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            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH83650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="209" mass="22703" checksum="9082C354E81ECE8A" modified="2015-07-22" version="1">MGSAKSKAAARRARVEEMRRKEAARERRSKQITYLASAVVVVATAVGGYFIVDSAREDEKAAAAPLKGEQSWDDLEQNHVTEDVDYKMTPPAGGDHDPAWQNCNGDVYDQPIRDENAVHSLEHGAVWVTYGDKAKEGDVKTLSERVTDTPYSLISPHPDQTGAITLSAWGKQLTVEKAADPKVGKFFDKYVQGPQTPEQGAACTGGKDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4V4</accession>
    <name>A0A0F7N4V4_9ACTN</name>
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        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_13250</name>
    </gene>
    <organism evidence="2 3">
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        <lineage>
            <taxon>Bacteria</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_13250"/>
    <dbReference type="EnsemblBacteria" id="AKH83036">
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    </dbReference>
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    <dbReference type="PATRIC" id="fig|444103.5.peg.2788"/>
    <dbReference type="OrthoDB" id="2081987at2"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="79" mass="8147" checksum="415655F1CEF59DE5" modified="2015-07-22" version="1">MNTGTSRPGDLLVRAGAIVFLVGALGTFVTFVPFFIGTDPLPTAAYLVSMLMGVGFGLALAGLFRSASASRREARQAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4V5</accession>
    <name>A0A0F7N4V5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidoglycan glycosyltransferase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AA958_09590</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23708"/>
            <dbReference type="Rhea" id="RHEA-COMP:9602"/>
            <dbReference type="Rhea" id="RHEA-COMP:9603"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:78435"/>
            <dbReference type="EC" id="2.4.1.129"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.4.1.129" evidence="2"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Kalinowski J."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
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            <end position="138"/>
        </location>
    </feature>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <sequence length="259" mass="26288" checksum="0A1F62E0FA2FFF64" modified="2015-07-22" version="1">MTRRLVFAEGRQAESLAVFLGRLLRYDRGAAVRLRVAAGAGGGAGGAALAVFGHAPALEVIVVRTALLTTAAAELDETVSAGELAEAIDAANAGAGSAAGAESAESAAAAPGAGSPAPGRESAVDLPQPVSGPGWAGLLPPRSGWEPVAGLPRPEELRVAVVAGVAEFKSRVEALPEEKRTRSEVDRIGGEIWSRPLGGTPLPLRAAHAARVFGLLPHPEDPAEPALLAAGNWLRLRTPYGSVALRRTGGLGRLGVTPV</sequence>
</entry>
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    <accession>A0A0F7N5L0</accession>
    <name>A0A0F7N5L0_9ACTN</name>
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                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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    </dbReference>
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            <end position="90"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="90" mass="9883" checksum="09491FCEEC74EEC2" modified="2015-07-22" version="1">MGRGRAKAKQTKVARQLKYSSGGTDLSRLAEELGASTTKPPSNGQQQQQQQVEEESPDDDLYARYAELYEDEDDDDGEDSAGSSEQRRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5X2</accession>
    <name>A0A0F7N5X2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GCN5 family acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_19300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017270.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH83975">
        <property type="protein sequence ID" value="AKH83975"/>
        <property type="gene ID" value="AA958_19300"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_19300"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4058"/>
    <dbReference type="OrthoDB" id="1462655at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="302"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="23"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH83975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="324" mass="35975" checksum="9A0E2BECEC9EE31C" modified="2015-07-22" version="1">MGSQEQAVEITRARLDHLSKIVALARERSLDATDPARASNEGFLVSDYTESTYRERLSSAEHFYVAVKGGDVVGFLLAYSDERLAADEWLNHWIKARLGSFLVIKQVCVARGMSRQGIASRLYTHILETWTASPVIAAVVAEPANLASTKFHRKHHFEELIELRPPDGHLRKIWIFHRSHGAMIQAQYPVAIDLYKHEDSVNWNKLSNFFYITAALAAATGFSLTSDSGKVRSIALMLPLIGLGLALAFSQMLLCGLRYLRARKDAVINIEDSLSWHGGARIVSHGISSPGNRWLRESPTGILMVSLPLLMAACWVVILIISLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N602</accession>
    <name>A0A0F7N602_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_19575</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017303.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_19575"/>
    <dbReference type="EnsemblBacteria" id="AKH84010">
        <property type="protein sequence ID" value="AKH84010"/>
        <property type="gene ID" value="AA958_19575"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_19575"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4125"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="28"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH84010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="367" mass="39540" checksum="C413669EF3E1AC20" modified="2015-07-22" version="1">MAAYRTTGGATGARGPLLTPGQRVHDGLVVDRRLGEGAFAEVYRVRHHVLGRQALKLFKHGASPGAHVSRLDEARILSTLGHPNIIRVFDAGTVDTADGVRGYFTMEYAAGGSLHRLVRSHGGFVPVPQVGAVLRQVADGLSVAHGRRQPVVHRDLSLANVLVAYDESGLRVKVGDFGLARETDPVTRAASAQGTVAYMPPEVLIRGRGYSAAGDVWALGTIVYYLLTNRFPYDADDPARGFSPARFEQPLRPPGDFNDDVDAALEWLVAEMLRVDPAERPAMREVAERAVLPGHPAAPPAERPPAPPPATAAPSADDPVRAAIALSRVPGRLADAADQLEAALSRRPRLRERHLTRLTTWRRGVVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6E6</accession>
    <name>A0A0F7N6E6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH gntR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_17025</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016935.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_17025"/>
    <dbReference type="EnsemblBacteria" id="AKH83631">
        <property type="protein sequence ID" value="AKH83631"/>
        <property type="gene ID" value="AA958_17025"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_17025"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3580"/>
    <dbReference type="OrthoDB" id="1911275at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="10"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH83631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="225" mass="25442" checksum="C41EA387D1EB3DD1" modified="2015-07-22" version="1">MSVDEDGRAVTARARAYEWVKEAILLGRYPEGSFLEEKVLSVAAGVSRTPVREALHRLAAEGFLDLLPRRGAQVRRVTVAEMIETYEMRQVLEIHGFRTLCDKRLEIPARQAELLAQMGDPELLARCRAGDREAIAEHGKLDFQFHFGFVRATGNTVLTDLFRSLQPRHQRIGVSAITIRPERLPLIMREHHALLDSLGGYEFETAARTIRTHLNPDQTVVAHLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6J6</accession>
    <name>A0A0F7N6J6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Biotin carboxylase</fullName>
            <ecNumber evidence="2">6.3.4.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AA958_13140</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CNQ-509</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="6.3.4.14" evidence="2"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016350.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_13140"/>
    <dbReference type="EnsemblBacteria" id="AKH83018">
        <property type="protein sequence ID" value="AKH83018"/>
        <property type="gene ID" value="AA958_13140"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_13140"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2765"/>
    <dbReference type="OrthoDB" id="361205at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004075">
        <property type="term" value="F:biotin carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
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        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001882">
        <property type="entry name" value="Biotin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CbamoylP_synth_lsu-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00188">
        <property type="entry name" value="BIOTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0092">Biotin</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="11">
        <location>
            <begin position="1"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="10">
        <location>
            <begin position="101"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="9">
        <location>
            <begin position="597"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="346"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AKH83018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="700" mass="72188" checksum="F73464018DCFE72C" modified="2015-07-22" version="1">MIRTLLVANRGEIACRVFRTCAELGITPVAVHSDADAGALHVRAALDAGGSAVRLPGRAASDTYLRADLLVAAALAAGADAVHPGYGFLSESAEFARAVTAAGLTWVGPPPEAIEAMASKTRAKELMGLAPFDPSKAVESDLPLLVKAAAGGGGRGMRVVRELAALDAGLASASAEAAAAFGDGEVFVEPYVEGGRHVEVQVLADAHGAVWALGTRDCSLQRRHQKVVEEAPAPGLAPGAAAELAETAVRAARAIGYVGAGTVEFLLAPDGRAQFLEMNTRLQVEHPVTEAVHGVDLVAAQVRIAEGAHLPPSAPQPRGHAVEARLYAEDPASDFAPQTGRVHRLEVGGAAGGPGRSPEGNRGGAPVPGRGGIGEPPTLRLDTGYTAGDTVTPYYDALLAKVIVHAPTRAEAVRHLTAALRRARIHGPVTNRDLLVRSLEHEEFTGGRMTTSFYDAHLPALTRPADEAGEPDAHLRLAALAAALADAAARQQAGDAALPARFGGWRNVPSQPQAKGYRAEPGGAEVEVRYRLTRDGIRADGLPDVRVLAAAPGRVVLEVAGVARAFDVAVYDAPAGGRPAPATYVDTPHGSYALSPLSRFPDPRADTPPGSLLAPMPGTVVRLADGIAPGQTVRQGQPLLWLEAMKMEHKVAAPASGVLTALHAVPGGQVEVGALLAVVEAAEDAAAHAALSRDQEGRQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6U6</accession>
    <name>A0A0F7N6U6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">5'-nucleotidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_13560</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5'-nucleotidase family.</text>
    </comment>
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        <property type="protein sequence ID" value="AKH83089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AKH83089">
        <property type="protein sequence ID" value="AKH83089"/>
        <property type="gene ID" value="AA958_13560"/>
    </dbReference>
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    <dbReference type="PATRIC" id="fig|444103.5.peg.2853"/>
    <dbReference type="OrthoDB" id="1884225at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="5'-Nucleotdase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036907">
        <property type="entry name" value="5'-Nucleotdase_C_sf"/>
    </dbReference>
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        <property type="entry name" value="5_nucleotidase/apyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575">
        <property type="entry name" value="PTHR11575"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02872">
        <property type="entry name" value="5_nucleotid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01607">
        <property type="entry name" value="APYRASEFAMLY"/>
    </dbReference>
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        <property type="entry name" value="SSF55816"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005117320" evidence="1">
        <location>
            <begin position="44"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="domain" description="Metallophos" evidence="2">
        <location>
            <begin position="62"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="5_nucleotid_C" evidence="3">
        <location>
            <begin position="410"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU362119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH83089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="611" mass="63740" checksum="F6C006B814E8FC20" modified="2015-07-22" version="1">MRSGRTEPSDRFRTTRRGRRAAAGAAALAVAGSLFAAAQPAGADSAEKQDRGRTVDVQLLSFNDFHGNLEPPQGSSGEVAELQPDGSKKTVKAGGVAYLATSLRDAREGNRYSVTAAAGDLVGASPLVSGLFHDEPTVEAMNGLGLDVAGVGNHEFDEGIAELRRLQDGGNHPEDGGYREGRTYGGADFPYLAANVTDEKTGKPALDPVYVWKKEGVKIGFIGVTLEATPDIVSAEGVKGLKFHDEIETIDTYAKQLRRQGVESIVALVHEGGYPAASAGGAYNYDCDTPGPGAGISGPVAEIAKGTTASVDAFVTGHTHQPYACTIPDPEGNPRSVTSASSFGRLYTDTTLTYDRRTGDIVRTATKLPDAENHVVDREQRRAPDMTSLVEEWNELAAPIAAKPVGYVSGDIPREGTESPLGDLIADAQLAHARTLDESTRVAFMNPGGIRAGITYASAGDEGDGVVTYGEGFTVQPFSNTVNLTGLTGEQLLQVLREQVSGANEAAPKILQPSAGLTYTLDLTESGADRVVADSVRLDGQPLDPAATYRVAVNSFLAGGGDGFPTLADGTDPLVGGDDLAALESYLTANSSADKPLAPPAADRITVIGQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6U8</accession>
    <name>A0A0F7N6U8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Multidrug ABC transporter ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AA958_13620</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016428.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_13620"/>
    <dbReference type="EnsemblBacteria" id="AKH83098">
        <property type="protein sequence ID" value="AKH83098"/>
        <property type="gene ID" value="AA958_13620"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_13620"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2866"/>
    <dbReference type="OrthoDB" id="643917at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="237"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="280"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="19"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="337"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="371"/>
            <end position="378"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AKH83098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="581" mass="62658" checksum="6175A5FC8B98CDEC" modified="2015-07-22" version="1">MLVRILRAHLRPYRRDLGWIVALQLVATVTTLYLPTLNADIIDHGVIPGDNGYILRTGGWMIVFSVVQFCAAGGAVFLGARTATALGRDMRASVFDRVQSFSAREMARFGAPSLITRTTNDVQQIQMLALMTFTMMVAAPIMCVGGIVMALNQDVPLTSLLLVVVPAVGVVVALIVRRMRPLFRSMQKRIDEVNRIMREQITGIRVIRAFVRDGHEQRRFGTANADLRDVGVRAGRLLALLFPTPMLAVNLSSVAVVWFAAGRIESGAMDVGALTAFLSYLMYILSSVMMATFMFMMIPRAEVCAERIQEVLDTESSVVPPAAPVPAAAEPRERGRLDLRGVGFRYPGAEEPVLKDVDLEARPGRTTAVIGSTGSGKSTLLALVPRLFDATGGSVEVGGVDVRDLDPAALALAIGYVPQKPYLFSGTVASNLRYGKPDATDDELWDALRTAQAADFVREMDGGLDAAVAQGGSNVSGGQRQRLAIARALVHRPDIYLFDDSFSALDYATDAALRAALARRLGDATVVIVAQRVATIRDADRIVVLDAGRVAGAGTHTELMAANETYREIVLSQLTEEEAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6X8</accession>
    <name>A0A0F7N6X8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Crp/Fnr family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_13845</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_13845"/>
    <dbReference type="EnsemblBacteria" id="AKH83138">
        <property type="protein sequence ID" value="AKH83138"/>
        <property type="gene ID" value="AA958_13845"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_13845"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2915"/>
    <dbReference type="OrthoDB" id="250058at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045641">
        <property type="entry name" value="MmpI-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19307">
        <property type="entry name" value="PCLP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="1">
        <location>
            <begin position="97"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="469" mass="51257" checksum="A0D7DF877988FE9F" modified="2015-07-22" version="1">MTTSPEETSASVELPARLSLDTAAARNLTTTTKTPPQMQGISSRWLLKALPWTEVKGGAYRVNRRLTHTLGDGQVEFTSVGDEVRVIPQELRELPQLRAYEDEEVLSALADRFAQREVAPGDAVVSAGSAADQVVLVAHGRLERVGTGKYGDETVLGVLADGDYIGGEVLLEADGTWPFTVRAQTRGTVLVLARSALDDLLAQAAGLREHLAAFGSLPQQRQNSKGEAEIALASGHHGEAELPGTFVDYELTPREYELEVAQTVLRVHSRVADLYNDPMNQVEQQLRLTVEALRERQEHELINNRSFGLLHNADLKQRIHPRSGPPTPDDLDELISRRRQTHVLLAHPRAIAAIGREWNKRGIYPPRTEYLGSEVNNWRGIPLLPCNKIPVTQEGTSSVIAMRLGEADQGVVGLHQTGLPDEIRPGMNVRFMGISDKAIISYLVSAYFSAAVLVPDALGILEDVQIGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N728</accession>
    <name>A0A0F7N728_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-ketoacyl-ACP reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_14265</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_14265"/>
    <dbReference type="EnsemblBacteria" id="AKH83203">
        <property type="protein sequence ID" value="AKH83203"/>
        <property type="gene ID" value="AA958_14265"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_14265"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3002"/>
    <dbReference type="OrthoDB" id="1294334at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH83203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="256" mass="27133" checksum="DFE0538A3C454A89" modified="2015-07-22" version="1">MTEESDSRTGDLRGRRALITGAGSGIGRAVALGLAAVGADLVLLSERDNLDPVAKEAAEWGVSVTRVHVDLTDPGARRGEIGHLVERFDLDILVNNSGLIRRAPAAEFRDADWYDVVELNLHAAFELTRAIGAGMLERGYGKIINIASVLSFQGGMYVPSYTSSKHALVGLTRALANEWAGRGVNVNAVAPGYIDTAVTSELRADGVRSSEILARIPAGRWGRPTDIAGPVVFLASPAADYVHGHVLAVDGGWLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N786</accession>
    <name>A0A0F7N786_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA polymerase sigma24 factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_14595</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016569.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_14595"/>
    <dbReference type="EnsemblBacteria" id="AKH83254">
        <property type="protein sequence ID" value="AKH83254"/>
        <property type="gene ID" value="AA958_14595"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_14595"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3074"/>
    <dbReference type="OrthoDB" id="1914729at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014325">
        <property type="entry name" value="RNA_pol_sigma-E_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02983">
        <property type="entry name" value="SigE-fam_strep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="5">
        <location>
            <begin position="16"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="6">
        <location>
            <begin position="106"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH83254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="179" mass="19596" checksum="CAD72AA60DEB05F7" modified="2015-07-22" version="1">MLRRGAAQPPGFEEFVAARGPRLLRVAWLLTGDAQLAEDLLQTVLAKVWPKWEQIADGSPEAYVRTAMVHTNISWWRRHWWGEVPHGELPDAAAPADAFAQVDLEQSLAAAIRRLPPRQRAVVVLRYFEDLSVQDTAATLGCAPGTVKSQSAKALRTLRGLLPEAELVEGGESGGLERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7E0</accession>
    <name>A0A0F7N7E0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MFS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_14965</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AKH83304.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="419" mass="42250" checksum="6BF0F32108E3B932" modified="2015-07-22" version="1">MTGLGADFRRLWLSSAVSNLGDGVRLTALPLLAAAVTRDPVAVAVVSVAAELPWLLVSLPAGALADRVDRRRLMVAVQLVRMCLAALLTATVLADRSSIAVLCAVVFLLGIGEVVYDAAAPTILPRIVPREQLTRGNARLFGVELGANEFAGPPLGGLLFRLGQAVPFVLDAVSFAASAALLSRLRGTFRPAGAADAPRAGVVRAIGEGFGWLWRHPVIRALSVVVTFMNLARAMTMAVFVLYALETLDLSAVGYGVLSSAVAVGAVAGSWAAERIRPAAAGPCLVAAVLGHGLTTVAMGATSNPWAAGASSAGFGFATMTWSVLTAAVRQTIVPDRLLGRISSVHRFLSWGSLPLGSLLGGVLAAAYGLRVPFAAGGAAVVLAALVAAPTLLGVSALLAGPGGAGGAGEAGGVSGSGS</sequence>
</entry>
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        <name type="scientific">Streptomyces sp. CNQ-509</name>
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        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
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    </dbReference>
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            <begin position="124"/>
            <end position="302"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="305" mass="33857" checksum="F48070AE24627176" modified="2015-07-22" version="1">MAGVTRWTGREAGLLRKAMRKTGKAFAELVGVNPRQIPRWEGRGETLELSLANQAALDTVLAQADPAVQQRFATLLTERAAVEQDERAEELLRRDTRTSRHPVDGKLMTVVDEGIYLSGPDSRSVWLEPYRIDVYPTTNADYERFVSATGHRSPRHWSAGRCPDDLVTHPVVWVTWHDATAYARWAGKTLPTAQQWEKAARGPRGRLYPWGNDPTAAKCNVSETGIDATTPVSRYQSGVSPYGAFDLCGNVWEWCSTEEQPGSGRYELKGSAFTSPFERTTPSLQNAANATMQDNDTGFRCVSPP</sequence>
</entry>
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    <accession>A0A0F7N7S5</accession>
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    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_15915</name>
    </gene>
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        <name type="scientific">Streptomyces sp. CNQ-509</name>
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        <lineage>
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            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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    <dbReference type="EnsemblBacteria" id="AKH83449">
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        <property type="gene ID" value="AA958_15915"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_15915"/>
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    <dbReference type="OrthoDB" id="1846332at2"/>
    <dbReference type="Proteomes" id="UP000034283">
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    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="157" mass="17143" checksum="22F794FC8E007EB0" modified="2015-07-22" version="1">MTVSHRPVVKRTARAVLLDGDEMLLIKRTKPGREPYWITPGGGVEPADASVVAALHREVDEELGARVTGVVPVFVDTVPEDGRGVKVQHFFACRLASMDPARRHGPEVDEPCGEYETVRIPFTREGVDSVDVVPPSLRAYLRTNIEGVLAVLADDFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7Y5</accession>
    <name>A0A0F7N7Y5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA polymerase sigma factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AA958_12405</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the sigma-70 factor family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016237.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_12405"/>
    <dbReference type="EnsemblBacteria" id="AKH82902">
        <property type="protein sequence ID" value="AKH82902"/>
        <property type="gene ID" value="AA958_12405"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_12405"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2607"/>
    <dbReference type="OrthoDB" id="1565734at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009042">
        <property type="entry name" value="RNA_pol_sigma70_r1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00140">
        <property type="entry name" value="Sigma70_r1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00715">
        <property type="entry name" value="SIGMA70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00716">
        <property type="entry name" value="SIGMA70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="1 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RNA_pol_sigma70" evidence="7">
        <location>
            <begin position="131"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_sigma70" evidence="8">
        <location>
            <begin position="300"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH82902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="339" mass="37562" checksum="B02870258DF03CCD" modified="2015-07-22" version="1">MATRAVARRQAETPAGGASSARGARARSGEIADRDLVGMYLDEIARTPLLDAAKEVELSLDIEAGVYAGKLLAGEAKPEAVDAPSASANREELEAIVAQGERAKDLFIRSNLRLVVAVARRYPRSGLPLLDLIQEGNAGLVRAVEKFDYKKGFKFSTYATWWIRQAITRSIADQSRTIRLPVHLVEELGRIRRVQREFNREHGREPEPAEVAAELGSTPERVTDVLDWARDPVSLNMSVDDEGETQFGDLLEDTGADSPEDSVLVMMRREELEGLIGRLEPRTASIIKARYGIEDGRERTLTEVGKQHGLTRERIRQIEKHALVELKKLARDTGFESAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N821</accession>
    <name>A0A0F7N821_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sulfotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_16585</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016864.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_16585"/>
    <dbReference type="EnsemblBacteria" id="AKH83559">
        <property type="protein sequence ID" value="AKH83559"/>
        <property type="gene ID" value="AA958_16585"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_16585"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3490"/>
    <dbReference type="OrthoDB" id="1555988at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008476">
        <property type="term" value="F:protein-tyrosine sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006478">
        <property type="term" value="P:peptidyl-tyrosine sulfation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026634">
        <property type="entry name" value="TPST"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12788">
        <property type="entry name" value="PTHR12788"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH83559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="315" mass="35316" checksum="1418AF057F8913B2" modified="2015-07-22" version="1">MGVVNTGIKRRARLLGEALRPPRQLTGPGTEAVPAAQVSPEAATPQKTPEKAKPKGPRPPKKTVATDYGVEAMPRQVEAPVFVLAPVRSGSTLLRMLLNSHSRIRAPHELHLRTLGVELTPGFSDQSMLELGLDRVELEHVLWDRVLHLELERSGKDIVVDKTPGNVWVWERLTYAWPKAKFLFLLRHPEGVVSSLDNRKSNTSTRAQNEANALKYFEPLERARTALDGHTLTYEDLTSDPERVMRGVCAYLEVEFEESMLAYGEQDHGRLRPNLGDRSDNIKSGRIQAARTFEERTAELSPQLAEYAAAWGYRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N832</accession>
    <name>A0A0F7N832_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phosphate transport system permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AA958_16650</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016874.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_16650"/>
    <dbReference type="EnsemblBacteria" id="AKH83569">
        <property type="protein sequence ID" value="AKH83569"/>
        <property type="gene ID" value="AA958_16650"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_16650"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3504"/>
    <dbReference type="OrthoDB" id="1325025at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011864">
        <property type="entry name" value="Phosphate_PstC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02138">
        <property type="entry name" value="phosphate_pstC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="86"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="129"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="298"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="92"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AKH83569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="332" mass="34783" checksum="23E1F3DDB65F1FDD" modified="2015-07-22" version="1">MTAPPTDRETPAPPPSQVLLSNGKGGSRRGDKVFSGLSKGSGIVLLLIMAAIAAFLAYRASLALADNEGNFLTTFEWDANAVPPKFGIAVLAFGTVVSSIVAMVIAVPIAVGIALFITHYAPRRLAAPLAYVIDLLAAVPSIVYGLWGALFLVPHLIGTYEWLDRYFGWTVVLSFDGTAPRSLMTAGILLAVMILPIITNVSREVFAQTPRLQEEAALALGATRWEVIRMTVLPFGRSGVISASMLGLGRALGETMAVATVLSPSALLSAEILQAGGGTFAQNIAASFGESGQFGRDALIASGLVLFVITLLVNGAARLIIARRKEYSGANA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N858</accession>
    <name>A0A0F7N858_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MerR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_16890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016913.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH83609">
        <property type="protein sequence ID" value="AKH83609"/>
        <property type="gene ID" value="AA958_16890"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_16890"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3554"/>
    <dbReference type="OrthoDB" id="1467120at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00376">
        <property type="entry name" value="MerR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="257" mass="28901" checksum="B3E664A352E01F99" modified="2015-07-22" version="1">MLTIGELASYAGVTVRAVRHYHAKGLLPEPDRDHSGYRRYDAAAVVELIRIRTLAEAGVPLARVRELLRAGEAEFAAAVADIDRRLRAEIRARRETRRRIARLTAGDSLALPAEVVAFLDRLRELGVDERIVAVEREGWIPLAAHSPDRVPEWLARKRAQLADPQFLDFYRTLGHALDWAPDDPRLTALADDLAAYLARLTAERGRDYVADVDLAPPFAELMDKLAFEAAPPARRLIGLLRKRGWTGWTRLEPLDPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N882</accession>
    <name>A0A0F7N882_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_12945</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016316.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_12945"/>
    <dbReference type="EnsemblBacteria" id="AKH82982">
        <property type="protein sequence ID" value="AKH82982"/>
        <property type="gene ID" value="AA958_12945"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_12945"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2724"/>
    <dbReference type="OrthoDB" id="1832160at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH82982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="166" mass="18179" checksum="AB3CDD833BE1BEFB" modified="2015-07-22" version="1">MQTLQVQLKVWPDPVEVGRARRWTRARLAWTGVTADEPYAESLVMLVSELVTNAVVHTDRPAELRLALPASAADCGPYRVEVVDTCAAPPRQRRAYEYETHGRGLELVDAIADRWGWQAEGFGKVIWCEIDRACAFAPPPGERADGADGALFAGAHEHARAGTNST</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8B8</accession>
    <name>A0A0F7N8B8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5 7">50S ribosomal protein L3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rplC</name>
        <name evidence="8" type="ORF">AA958_21175</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 7">One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 7">Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uL3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018834848.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_21175"/>
    <dbReference type="EnsemblBacteria" id="AKH84286">
        <property type="protein sequence ID" value="AKH84286"/>
        <property type="gene ID" value="AA958_21175"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_21175"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4460"/>
    <dbReference type="OrthoDB" id="1270636at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01325_B">
        <property type="entry name" value="Ribosomal_L3_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000597">
        <property type="entry name" value="Ribosomal_L3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019927">
        <property type="entry name" value="Ribosomal_L3_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019926">
        <property type="entry name" value="Ribosomal_L3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11229">
        <property type="entry name" value="PTHR11229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00297">
        <property type="entry name" value="Ribosomal_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03625">
        <property type="entry name" value="L3_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00474">
        <property type="entry name" value="RIBOSOMAL_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH84286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="214" mass="22508" checksum="E38ECA3682975019" modified="2015-07-22" version="1">MAKQIKGVLGEKLGMTQVWDENNRVVPVTVVKAGPCVVTQVHTADSDGYDAVQIAFGEIDPRKVNKPLKGHFAKADVTPRRHLVEIRTADASEYTLGQEVTAETFEAGVKVDVTGKSKGKGFAGVMKRHGFAGGKASHGAHRVHRKPGSIGGCATPGRVFKGMRMAGRMGNQRVTTQNLTVHAVDAEKGLLLIKGAVPGPNGGLVLVRSAAKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8E9</accession>
    <name>A0A0F7N8E9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_17770</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017050.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_17770"/>
    <dbReference type="EnsemblBacteria" id="AKH83748">
        <property type="protein sequence ID" value="AKH83748"/>
        <property type="gene ID" value="AA958_17770"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_17770"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3741"/>
    <dbReference type="OrthoDB" id="1911275at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="11"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH83748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="226" mass="25185" checksum="EEF345C843DE3390" modified="2015-07-22" version="1">MTPAGAVVRRDTLRAQIADALRDEILAGRLAAGQNITVGEIAEQYGVSATPVREALVDLSAQGLLDVEQHRGYRVHAFTLDDFRAMADARTVVQMGVFRATPPHIVDPPPGALVAMRRRGEEAERAAKAGDLDVLVHYDLRFWREITSLIGNDYITEFLERVRIHCWVFAVPYLRAASEDCVPGTFWQGHMQLVEAIERRDVAAAEEVVRTYNRHSLELIERLAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8H5</accession>
    <name>A0A0F7N8H5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_18130</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017108.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_18130"/>
    <dbReference type="EnsemblBacteria" id="AKH83808">
        <property type="protein sequence ID" value="AKH83808"/>
        <property type="gene ID" value="AA958_18130"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_18130"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3812"/>
    <dbReference type="OrthoDB" id="1563532at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="180"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="60"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH83808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="298" mass="30866" checksum="69F0B3DBDB704DA7" modified="2015-07-22" version="1">MRGLLPPVSFAAVALGCAAGAWLVSGDGAAVRWLAAGAAGAAVGASALMRLRDRMAALQVTEATGARARAEREHEEKLAELKRDLEEARRVRGELEKRLGSRHGDLARLRTDHAALLARYANAESERAAALEGRRQLAIEAATPVKQLPPAGSRPQIGPPSLSQYLRASHALDNLAGNAARQGHGQTHEQAPSGDAAGFSYFSRPQRAQSRETPPPASGRRAGGGHRSGPDEPGDAGTDLADVVGPEVLAEAQAEAEAEADKGAEAGSDAVPAPSEADDPDDDPHGPVGRVIDLEQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8I0</accession>
    <name>A0A0F7N8I0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_13410</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016393.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_13410"/>
    <dbReference type="EnsemblBacteria" id="AKH83062">
        <property type="protein sequence ID" value="AKH83062"/>
        <property type="gene ID" value="AA958_13410"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_13410"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2820"/>
    <dbReference type="OrthoDB" id="1108236at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="238"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="302"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="314"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="343"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="367"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="408"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="451"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="22"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="474"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH83062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="500" mass="52120" checksum="4DC03BC7B2FAED89" modified="2015-07-22" version="1">MRVAIAKRFSADEAAEGRTPTVVRLLVLATFVVILNETIMINAIPRLMESMDVTEQAAQWVSTAFMLTMATVIPVTGWFLQRVTTRRAYAVAMSTFLAGTVVSAVAPTFAVLLAGRIVQAAGTAVMMPLLMTTLMAVVPSEHLGKVMGHVTLAMSTAPALGPTVSGVILQAGSWRLLFVVVLPIAALVTVFGLRKLENIGEPQVSSIDWVSVGVATLGFGGLVYGLSLIGEHDRRSTGIGIAVAGLVAVGLFAFRQLRLQRKGTPLMDLRTLRYGAFTRSLAVMSVGFLAMMGSMILLPLYLQNVRGLSPLETGLLVMPGGLAMGLLGPTVGKVFDRFGSRGLVVPGSAGIAAALFGYSQISMTTPYGLILALHVILMISLAATFTPVFTLGMGALPPHLYSYGSSILGTLQQVAAAFGTALVVTVMSSRATSLVDAGMAPVPAQVSGMKLAFGVAAALAVAMIALAATLPRRVETPSEDDAAPGTEPEKAPAPDDRVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8M6</accession>
    <name>A0A0F7N8M6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_18380</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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    <dbReference type="EnsemblBacteria" id="AKH83848">
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        <property type="gene ID" value="AA958_18380"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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            <begin position="24"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="SCP_3" evidence="2">
        <location>
            <begin position="185"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH83848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="279" mass="28914" checksum="0A4E675338D109DB" modified="2015-07-22" version="1">MTTAKRSGARRARTYDPDKTWTALTAQVRALSAAAHALDERRLALPSGLPGWDVRLLLAHVAGEIETVPRLLAEPPPAAVRAAVDLPRWAVSTAGAADDLAAGAVRDAERISTAYGDGPAALASALDAAAERLAAAAPEAVRSDRLLPHRFGPMTALDVTVTRLVELVVHSDDLTRATGADVTLDRGAVAATVRVLADALAAKSPGAAVEVRIPPYAAIQCIEGPRHTRGTPPNVVETGPLTWIRLATGRTEWAAALEEGSVAASGERADLSGVLPVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8T6</accession>
    <name>A0A0F7N8T6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="2 3">
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        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_13925"/>
    <dbReference type="EnsemblBacteria" id="AKH83152">
        <property type="protein sequence ID" value="AKH83152"/>
        <property type="gene ID" value="AA958_13925"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_13925"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="13"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="396" mass="44379" checksum="4BF68ABD69005E0A" modified="2015-07-22" version="1">MPDHPEEHIGDRLRSVRKRRGLTQRELAAAAGLSVSLVRKLEQGELTDTRLETARRFAVALRVPTSSLIRSRTDEVADPPTFDRWASVRQALSSPPPDDITEPPTAGGVRSALEDMLRLRARHQFVEIADVLPRLLRDAEILAAHTREGRHLRFRVMLLTGWLLTQTRQFDAAEELMSRHLQDAGDHVQGIAMVNSLCWLLLRQGRLGEAHEYAVRWADDAEPARLSRATADELAAWGWMLLRVSNSSVRDARDGAAADALRMAQAAAVVIGHEQQSGADPIRMFGPTTVALKECENAMILDQPDHVLALAEPLAAGGMRTTLANWSRHRLDVANAQVRLRRYSDAMTTLRQVRAAAPQWLPHQRYARDIVGRVVERRRTLTPEMRELADTVRLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8U1</accession>
    <name>A0A0F7N8U1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Adenine DNA glycosylase</fullName>
            <ecNumber evidence="4">3.2.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">AA958_18315</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolyzes free adenine bases from 7,8-dihydro-8-oxoguanine:adenine mismatched double-stranded DNA, leaving an apurinic site.</text>
            <dbReference type="EC" id="3.2.2.31"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Nth/MutY family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.31" evidence="4"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017138.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_18315"/>
    <dbReference type="EnsemblBacteria" id="AKH83839">
        <property type="protein sequence ID" value="AKH83839"/>
        <property type="gene ID" value="AA958_18315"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_18315"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3849"/>
    <dbReference type="OrthoDB" id="1274533at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
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        </source>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="AKH83839.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="314" mass="33939" checksum="BBE44C4AD09474C0" modified="2015-07-22" version="1">MTATTASTASAPASAGAAPASAPEPAALHGPVLQWFHEHARDLPWRRPEAGPWGVMVSEFMLQQTPVSRVLPVYTQWLKRWPRPADLAAEAPGEAVRAWGRLGYPRRALRLHAAATAIKERHNGDVPKRHAQLLALPGIGEYTAAAVASFAYGQRHAVLDTNVRRVYARLVGGTEFPPGATTAVERRVARELLPEKDAEAARWGAATMELGALVCTARKPECGKCPVATLCAWRLAGHPAHAGPPRRTQTYAGTDRQVRGRLLAVLRDADGPVPQQRLDAVWHEPVQRARALDSLVSDGLVEPLADGLYRLPQG</sequence>
</entry>
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    <accession>A0A0F7N986</accession>
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
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        <location>
            <begin position="6"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH85100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="184" mass="19463" checksum="B239AA5C54297376" modified="2015-07-22" version="1">MAEHRTMQHAALLDAARELLGEGGTEALNFAALAERTGLARSSVYEYFRSRAAVVEELCAVDFPRWAAEVEAAMERADTPEAKVEAYVRTQLALVGDRRHRAVVAISAGELDAGAREKIRAAHGGLVTMVVAALADLGHDEPRLAATLLQGVVDAAVRRTELGTDAPETVADTAVAVALHGAAR</sequence>
</entry>
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    </gene>
    <organism evidence="3 4">
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        <lineage>
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        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017402.1">
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    </dbReference>
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    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_20160"/>
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    <dbReference type="OrthoDB" id="1928091at2"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
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    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF01370">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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            <begin position="5"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="343"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH84113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="362" mass="38686" checksum="DB9C3ADF5EF1BA44" modified="2015-07-22" version="1">MGRTVLVTGVARPLVGRLVRRLMREPDVDRVVGVDARAPEHQLGGADFVPADIRHPVLARILVEHRVDTVMHMDVTGTPLTRGGRGAVKENNVIGSMHLLGACQQAPRVRRLVVKSTTSVYGSAPRDPAVFTESTPPKALPSGGFAKDAVEVEGYVRGFARRRPDVAVCVLRFANILGPRVDTPLAEYLALPALPTVLGYDPRLQFVHEDDVIEVLLLAAGEPRRGTINSGTFNIAGEGVLLLSQAARRLGRPTVPVPLPAVTWVGSALRSAGMTDFSPEQIRLLTHGRVVETTQMRELLGFTPEYSTAEAFADFAAGRAAGLLPPREVRRAVDAVGELLGLPGTRTPAQGDGVAKESVPDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9D4</accession>
    <name>A0A0F7N9D4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_20275</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017422.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_20275"/>
    <dbReference type="EnsemblBacteria" id="AKH84133">
        <property type="protein sequence ID" value="AKH84133"/>
        <property type="gene ID" value="AA958_20275"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_20275"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4269"/>
    <dbReference type="OrthoDB" id="1261526at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH84133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="249" mass="25742" checksum="C5DF773F9B4E0B70" modified="2015-07-22" version="1">MPTAVVTGASSGIGAATARQLAAAGHHVVLTARRKDRIDALAEELTAAGHAATPYALDVTDRAAVDAFAASLESCDVLVNNAGGALGTEQVEAGDPADWRAMYEVNVIGTLNLTQALLPALVASGDGTVVIVTSTAGHAVYEGGGGYVAAKFAEHSIAATLRLELNGRPVRVIEIAPGMTRTEGFAVTRMRGDAEKAAAVYAGVKEPLTSEDVADTITWAVTRPAHVNVDLLVVRPRAQAANYKVHREP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9E7</accession>
    <name>A0A0F7N9E7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_26350</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018406.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_26350"/>
    <dbReference type="EnsemblBacteria" id="AKH85165">
        <property type="protein sequence ID" value="AKH85165"/>
        <property type="gene ID" value="AA958_26350"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_26350"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5547"/>
    <dbReference type="OrthoDB" id="1479518at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="209"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="273"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="319"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="125"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH85165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="351" mass="37769" checksum="88F8DF7BE983B18B" modified="2015-07-22" version="1">MSTADPSVTPAAVRSAPDARGSAGSSRRAYLSYVAGKLAGAAVSLFAILVTSFFLFRIIPGDPVKTMTHGRKADAEQLAALRRQYGLDLPLWEQFTHYVGDALTGNLGDSYQFNKPVLDLIWERVPATLLLTGTAVVLYSALGLWLGTRAAWRHGGLGDKVNTSIALTLWSVPHFWLGMLLIIVFSVGIGPVPGLFPTGGMESGDEHGVAYVVDVIHHMFLPVLTLVAACYAQTLLVMRSSLLDEMGSDYLTAARAKGLRDDLVRRRHAVPNAMLPTITLVFVNLGFIAAGSILVETVFSWPGLGGLFYQALSIPDLPLIQGLFIVYAGSMILASVVADLIYPLFDPRVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9U8</accession>
    <name>A0A0F7N9U8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cobalamin biosynthesis protein CobW</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_16005</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIMIBI class G3E GTPase family. CobW subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016774.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_16005"/>
    <dbReference type="EnsemblBacteria" id="AKH83462">
        <property type="protein sequence ID" value="AKH83462"/>
        <property type="gene ID" value="AA958_16005"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_16005"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3372"/>
    <dbReference type="OrthoDB" id="1267701at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011629">
        <property type="entry name" value="Cbl_biosynth_CobW-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036627">
        <property type="entry name" value="CobW-likC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07683">
        <property type="entry name" value="CobW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00833">
        <property type="entry name" value="CobW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CobW C-terminal" evidence="2">
        <location>
            <begin position="235"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH83462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="353" mass="37721" checksum="A73C5D7BA0EAD595" modified="2015-07-22" version="1">MGSGRIPVVVLAGFLGSGKTTLLNGLLRNGTGTRIGAVVNDFGSIEIDAMAVAGQVDSMVSLGNGCLCCAVDTSELDAYLDRLAGTGRIDVIVVEASGLAEPQELVRMVLASENDRIVYGGLVEVVDGAEFAATRERHPEIDRHLAVADLVVLNKTDRIDDAERRRLHEAIGELAPGTPVVATAYGRVDPELFFDPRGDDAPGAAAPRHRQLSFADLAAGECTGDDHGAHLHAAYESVEFTTDRRVSPRRLLDFLDTRPAGLYRVKGFVHFGVPGHPQKYGLHAVGRFLRFRPAPWGSGEERVTRLVLIGAGIDADAVRKELDACRGHGPQDGGEDAMWGVLRYVDGDEDPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NA68</accession>
    <name>A0A0F7NA68_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_25090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018192.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_25090"/>
    <dbReference type="EnsemblBacteria" id="AKH84941">
        <property type="protein sequence ID" value="AKH84941"/>
        <property type="gene ID" value="AA958_25090"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_25090"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5288"/>
    <dbReference type="OrthoDB" id="1900357at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="443" mass="44743" checksum="6FA0295D51D1A14F" modified="2015-07-22" version="1">MRPDDHARAARGGPRHAAPRRSLLGRVPAGKAIALAAMPTAVFLGLGLTPRPAIAEDAPADRWRPGPCAEQSDEPKDEETADAGEARDGEEAPGAGESAEPGGGASPSPSATDDGSAAERPGGGGGDGPGADSGSGGASGGGSDGDGAGESGKAEPSPSPSESRPWYDPLGLGDAVDGLLNPDDPGAEPEPGAEPPGGSDGADSGAGTSGSGSGSDSGEESGSGTAPDEERRAKEKAVRDAAEDAGATVEELDDKVRDTAEDPADEKPDAGDGTAADGDGKEPFPCPTPDPEALANAPLEPGLPLLPDDPWRLESSKLTLKGLKYHGIVEVKTYSGQVKKVLKYTADDGVDIRDLHQTVIGPGRNTTHVRAEEGSTSTIRDGRVTMYTEELKGNLFGLIPMTFSPGSPPPVDLPFAFFTDVQVVQAGQFGGTLTVPGLKNTIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAV4</accession>
    <name>A0A0F7NAV4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_26645</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018453.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_26645"/>
    <dbReference type="EnsemblBacteria" id="AKH85216">
        <property type="protein sequence ID" value="AKH85216"/>
        <property type="gene ID" value="AA958_26645"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_26645"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5607"/>
    <dbReference type="OrthoDB" id="1468733at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519259" evidence="2">
        <location>
            <begin position="30"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH85216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="393" mass="41497" checksum="0194DECC629CC133" modified="2015-07-22" version="1">MPANGKRRIRRKALAAAALAATLALTAGACEDGGGDSGADDKQQEQESQAPEKELALPEGIPDALKNLDLDKWRDGGWEDWAKEDWLRDAREFVNPIIEDLWDPDRMWDAEQPPSRVDEDDVSEDQGVTDPEPAPVEAVEAATPYDESQPAAGKIFFDTPEGPMVCSGTVVADPANPGKSNLVATAGHCVHKGSDGGWWRNVIFVPSFNPEGKTVAELEAEQATEADIAPKGTFWAEEARTTDEWISEGKSQGGVGAPYDFAVMKVQPKDGGGQSLEETVGASVPVWFDAPAVNDVGDLTATGYPAAAPYDGGRLYSCTDAAGRLSIQASQPTMYRIGCTMTAGASGGGWTASNGGEEQLVSVTSIGPLQATWLAGPRLDKEAEAVFDEVSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NB43</accession>
    <name>A0A0F7NB43_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glutaredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_23465</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017929.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_23465"/>
    <dbReference type="EnsemblBacteria" id="AKH84674">
        <property type="protein sequence ID" value="AKH84674"/>
        <property type="gene ID" value="AA958_23465"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_23465"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4947"/>
    <dbReference type="OrthoDB" id="2045232at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097573">
        <property type="term" value="F:glutathione oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011915">
        <property type="entry name" value="GlrX_actino"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02200">
        <property type="entry name" value="GlrX_actino"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="3">
        <location>
            <begin position="5"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH84674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="85" mass="9132" checksum="10E07B0AE5C4D767" modified="2015-07-22" version="1">MAGTVTMYSTTWCGYCRRLKSQMDREGIPFEEVNIEQDPDSAAYVESVNNGNQLVPTVVVVPRQGGESVAMPNPSLAQVKAALGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBF0</accession>
    <name>A0A0F7NBF0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Alanine-rich protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_24150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_24150"/>
    <dbReference type="EnsemblBacteria" id="AKH84793">
        <property type="protein sequence ID" value="AKH84793"/>
        <property type="gene ID" value="AA958_24150"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_24150"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5089"/>
    <dbReference type="OrthoDB" id="538762at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH84793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="410" mass="43196" checksum="136DEEDA84686BA2" modified="2015-07-22" version="1">MYTLMMTPRASVFLYPWDVVGDPAAARRVAELGVRQVTLAAAYHSVRAVTPRHPRHRIVTARHSAVLYPPDARLWAGRALHPYEQDWVAAADPFGEAAEALAGAGLEVHSWVVLAHNSRLGAEHPETSVVNAHGDRYPWAPCIGRPDVRDYLVRLAAEAATRPGVRGCELESCGWYGLAHLHAHDKTGGVALDAAGRLLMSLCFCDRCRDGYAAYGAEPDDLRSAVTAALRPYWDGTAAAPPAAAEAVEAAGTWARIVGLLGAERAAAVLGWRRAAATRLQREAVEAVRAEAPDSAFRVLLHATPEPYACGANAGVDPAEVLQFADGLVLPCTGGPAARTAALDPCAPHRRPHTTLAANFTVVSGMGGTPATLAADAAHAAKLGADELRLYHGGLASAEDLTRIAEALGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBJ9</accession>
    <name>A0A0F7NBJ9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_19940</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="2"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017367.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_19940"/>
    <dbReference type="EnsemblBacteria" id="AKH84077">
        <property type="protein sequence ID" value="AKH84077"/>
        <property type="gene ID" value="AA958_19940"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_19940"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4201"/>
    <dbReference type="OrthoDB" id="114076at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="6">
        <location>
            <begin position="185"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="206"/>
            <end position="213"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH84077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="688" mass="74192" checksum="FA676A8252DE6BD9" modified="2015-07-22" version="1">MSDPTPTTGTAPSPAPPAPLVRERAHLAASRTALRAMRADAEALDLTDVTASWVSGEVLQAEIDLRIKALADLADTPLFFGRLDYAREGSPGEHFYIGRRHVHDADGDPMVIDWRAPVSQPFYRASKQDPMDVSLRRRFGYDRGEITAYEDEHLTDPHEAAKSSALLQREIERPRVGPMRDIVATIQPEQDEIVRAEIGGTVCVQGAPGTGKTAVGLHRVAYLLYAHRERLARTGTLVIGPNDSFLRYIEQVLPTLGELDVKQATVAELVAHVEVRGSDPAPVARLKGDARMAEVLRRAVRAGVTMPTEPVVVVRGSRRWRVPAYEVEELVRELLARDIRYNSAREALPQRIAHAVLVRMERAGEAPDDRVQDAVARNPAVKAAVKAIWPAVDPVKLVLRLLSDAGFLAAHAEGILDADEQRLLLWEKAPRGVRSARWSAADAVLIDEARDVVERTPSLGHVVLDEAQDLSPMQYRAVGRRCSTGSATVLGDIAQGTTPWATESWAVALAHLGKPDAVVEELTQGFRVPREVIAYASRLLPSIAPGLKEATSIRESAGDLAVRALPRAALDGSVAEACGSVLRTREGSVGLIAADGRVAALGAALAAAGLPFLSPGEETSSEARLTLVPASLAKGLEYDYVVLDDPATIVAAEPDVRTGLRRLYVCLTRAVSGLTVLHAEPLPPELAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBK6</accession>
    <name>A0A0F7NBK6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_30635</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019078.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH85850">
        <property type="protein sequence ID" value="AKH85850"/>
        <property type="gene ID" value="AA958_30635"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_30635"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6474"/>
    <dbReference type="OrthoDB" id="1567592at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010296">
        <property type="entry name" value="DUF899_thioredox"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05988">
        <property type="entry name" value="DUF899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH85850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="228" mass="25850" checksum="26BC0A1843673EFF" modified="2015-07-22" version="1">MTAHALPPVVDTGTWRRELDALRVREKAATRELDAIAAQRRRLPMVEMPDYTLEGEEGPVRLVDVFDGKSQLIVYNHMWFEDKEWQCGGCTSYTAQFTRFGFLEPYDARFVIVTQGPIDQALAYKKRVGNKMTWYSTANSPFGADVDAPKGGGFALNVFLRDGDTVYRTWHSSGRGTEQLSHTFPLVDVLPYGRQEEWQDSPEGWPQSPAYSGWLDSKDIARLYGEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBN0</accession>
    <name>A0A0F7NBN0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_24525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018100.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_24525"/>
    <dbReference type="EnsemblBacteria" id="AKH84848">
        <property type="protein sequence ID" value="AKH84848"/>
        <property type="gene ID" value="AA958_24525"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_24525"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5167"/>
    <dbReference type="OrthoDB" id="1515497at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="40"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="249" mass="26776" checksum="CE4CADE1C7A91A17" modified="2015-07-22" version="1">MDPADFYTGIVAELYGPLKSVAQDPEPYAAFIEEAGTPALELGCGDGEPLLELRRRGLDVDGVDSSADMLDRLRRRAAEEGLPVRVFQQRMEALDLPRRYAAVFLAGPTFNLLPDDATALAALRAIRTHLAGGGTALIPLHLPAPTAAADVGRARTATGPDGAELRVRVVAESRDEHTRTQTTLLRYERYHPSGSSITERPWVLHWYTRDGFETLAAVAGLDVAGITEPDGGPAAPDAGHIHVRLRAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBP5</accession>
    <name>A0A0F7NBP5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_28945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018839.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH85606">
        <property type="protein sequence ID" value="AKH85606"/>
        <property type="gene ID" value="AA958_28945"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_28945"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6098"/>
    <dbReference type="OrthoDB" id="2020052at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025161">
        <property type="entry name" value="Put_IS4/IS5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13340">
        <property type="entry name" value="DUF4096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_Tnp_1" evidence="1">
        <location>
            <begin position="96"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="260" mass="30180" checksum="3D22A40B70A7C38A" modified="2015-07-22" version="1">MTDAEWAVVRSLLPVPAWMNGKGGRPEGYCHRQMIDAIRYLVDNGIKWRAMPADFPAWDRVYAFFRRWRDHRLITEFHDRLRARVRESEGREREPTAAIIDSQSVKAAASVPARSRGFDGGKKINGRKRHLIVDCLGLLLMVLVTPADVTDRDAACGMLPRLLARHRKIRLVWADGGYAGRLVDWARNRLRLTLEIVKRSDDTRGFVVLPRRWCVERTLGWLMRSRRLTRDYETRPATSEAVVHWSMAMLMGRRIARHRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBS5</accession>
    <name>A0A0F7NBS5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ferredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_29150</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018865.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_29150"/>
    <dbReference type="EnsemblBacteria" id="AKH85636">
        <property type="protein sequence ID" value="AKH85636"/>
        <property type="gene ID" value="AA958_29150"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_29150"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6146"/>
    <dbReference type="OrthoDB" id="1885467at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000951">
        <property type="entry name" value="Ph_dOase_redase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00409">
        <property type="entry name" value="PHDIOXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="6">
        <location>
            <begin position="3"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="5">
        <location>
            <begin position="231"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH85636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="316" mass="33526" checksum="AF750ACB57832C03" modified="2015-07-22" version="1">MTADTHDLDLVVDGRHVAADGVLALTLRRPGGELPAWEPGAHVDLLLDGGLVRQYSLCSDPADRRTWRIAVLREAAGRGGSAQVHDRLHEGTKVRARGPRNTFALRPAARYRFIAGGIGITPILPMVAAADAAGADWSLLYGGRTRASMAFTGELARYGDRVGIAPQDESGLLDLAPYLAGAGPDTLVYCCGPAPLLDAVAQQCGGRPPGTLHMERFQPRTAPREGTDHAFEVVLAHSGRTLTVPADASVLDTVRAAGVEVLYSCTEGTCGTCETDVLEGTPDHRDSLLSEEEREAGESMMICVSRCRGPRLVLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NC05</accession>
    <name>A0A0F7NC05_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glucanase</fullName>
            <ecNumber evidence="8">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AA958_29910</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the glycosyl hydrolase family 6.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="8"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018969.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_29910"/>
    <dbReference type="EnsemblBacteria" id="AKH85741">
        <property type="protein sequence ID" value="AKH85741"/>
        <property type="gene ID" value="AA958_29910"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_29910"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6316"/>
    <dbReference type="OrthoDB" id="1331351at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016288">
        <property type="entry name" value="Beta_cellobiohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036434">
        <property type="entry name" value="Beta_cellobiohydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001524">
        <property type="entry name" value="Glyco_hydro_6_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34876">
        <property type="entry name" value="PTHR34876"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01341">
        <property type="entry name" value="Glyco_hydro_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001100">
        <property type="entry name" value="Beta_cellobiohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00733">
        <property type="entry name" value="GLHYDRLASE6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51989">
        <property type="entry name" value="SSF51989"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00656">
        <property type="entry name" value="GLYCOSYL_HYDROL_F6_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2 8" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="4 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005117496" description="Glucanase" evidence="8">
        <location>
            <begin position="28"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6 7">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001100-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH85741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="322" mass="33509" checksum="85E4CA3B97EBE4C3" modified="2015-07-22" version="1">MRKLIRGAVAALLALPLFLASSPSAQAAPTPLAMTSGFYVDPNSSPAVWSAANPGDGRAAAIRNSIAGTPMARWFGSWSGDIGSAVGSYTGAAQAADKLPLLVAYNMYGRDACGGHSGGGASSPSEYARWIDSFARGIGSRPAVVVLEPDALGDYSCMSQAQIAERQNMLTNALSQFRSSAPNAWVYLDAGNPRWVDASTMAQRLHSSGLSLARGFSLNVSNYFTTSENVSYAGGVNQALGQRYGYSKPFVVDTSRNGNGSNGEWCNPGGRKIGTPTQQGGGAEMLLWVKTPGESDGNCGVGGGSTAGQFLPEVAYKMIYGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NC15</accession>
    <name>A0A0F7NC15_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Big_3_5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_20935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_20935"/>
    <dbReference type="EnsemblBacteria" id="AKH84247">
        <property type="protein sequence ID" value="AKH84247"/>
        <property type="gene ID" value="AA958_20935"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_20935"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4411"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032109">
        <property type="entry name" value="Big_3_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16640">
        <property type="entry name" value="Big_3_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Big_3_5" evidence="1">
        <location>
            <begin position="3"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="92" mass="9471" checksum="2F6A8FD8856385C1" modified="2015-07-22" version="1">MSFFDGPDLLATVPVAPDGTATYDTNFATTGTHTITAAYNGNDNCAASNDQTTVVISSSPTPPTPPYGFCALACGSLINFTVGNIDNDVTVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NC25</accession>
    <name>A0A0F7NC25_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_25390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018245.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_25390"/>
    <dbReference type="EnsemblBacteria" id="AKH84994">
        <property type="protein sequence ID" value="AKH84994"/>
        <property type="gene ID" value="AA958_25390"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_25390"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5352"/>
    <dbReference type="OrthoDB" id="1600458at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH84994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="167" mass="18947" checksum="EEE16D90DA20B325" modified="2015-07-22" version="1">MISGLPGSGKSTLMRRTQPPAAVRLIDSQYVRERWARKLGRRLPYALYRPLVRIDHYARLRLAVRAGGSLVVHDCGTLPWVRWWLTRQARRHGRGMHVVVLDVPAAVARERQARRGRAVSRYAFARHRWAHRRLLDWASAGQPAEGCHSVLVLDGEATGTLRSISFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NC91</accession>
    <name>A0A0F7NC91_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metal-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_25835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018318.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_25835"/>
    <dbReference type="EnsemblBacteria" id="AKH85074">
        <property type="protein sequence ID" value="AKH85074"/>
        <property type="gene ID" value="AA958_25835"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_25835"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5441"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003772">
        <property type="entry name" value="YceD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02620">
        <property type="entry name" value="YceD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="226" mass="24628" checksum="C4605A49D438B9F2" modified="2015-07-22" version="1">MRRVHESRKALKAHPDHRAPLVFDTRELGRRPGTLKRLSRTVPAPKDLGNEVVGVPEGDPVELELRLESVMEGVLVTGTARARATGECVRCLEPLGQELRVDIQELYSYPETDARGRVARGGGSGADAEEADAEEETLYLEDDMFDLEPELRDAVVLALPLQPVCREDCPGLCPDCGARLADDPDHRHDVVDARWAALQGLAETVSDGEKNDTSGADDGAGEKQEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7ND41</accession>
    <name>A0A0F7ND41_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_27490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018588.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_27490"/>
    <dbReference type="EnsemblBacteria" id="AKH85354">
        <property type="protein sequence ID" value="AKH85354"/>
        <property type="gene ID" value="AA958_27490"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_27490"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5792"/>
    <dbReference type="OrthoDB" id="504223at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005198">
        <property type="entry name" value="Glyco_hydro_76"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03663">
        <property type="entry name" value="Glyco_hydro_76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519379" evidence="1">
        <location>
            <begin position="29"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="489" mass="52651" checksum="401167CE5E3BC26E" modified="2015-07-22" version="1">MKRLATLTAAAALAAGSLAAAPAPTSAAQPPPAAPELARICNVYCDARDPAQATRDRTAVTATLFSRTLALHVDDDSAMGWATIGNGSPGDEVWLDRSFDGGRTWASGSRLGNTAVPAGQRGWRTGMYNVDDWANRGVGALRACGKAADRPDIACTPWARSTWNAWDRRTAAATAQMSFYDQATGLFATTGWWNSANALTAVIDNIRVSGMRSYEYAIGHTYDRQLGAHQGQFRNDYIDDTGWWGLAWIAAYDLTGDRRYLDTARADADHMAAYWDGRCGGGVWWSQAKTYKNAISNSLYIHLNAALHNRIAGDTAYLKRARDGWSWFQGTGMINGSSLVNDGIDLGTCRNNGQPVWSYNQGVLLGALTELHRATGDDTLLTTARRLADAATTAPSLHTADGILRDPCESGDCGADGPSFKGAHVRGLGKLNAALPDHPYTAYLTRQADRAHAADRNALDQYGLRWYGPLDTTDAARQQSALDLMNAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7ND55</accession>
    <name>A0A0F7ND55_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF397 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_27575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018603.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_27575"/>
    <dbReference type="EnsemblBacteria" id="AKH85369">
        <property type="protein sequence ID" value="AKH85369"/>
        <property type="gene ID" value="AA958_27575"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_27575"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5810"/>
    <dbReference type="OrthoDB" id="1996962at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="7"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="63" mass="6776" checksum="B76EFBF8EE4EEAF2" modified="2015-07-22" version="1">MSRIGPEWFKSSYSGGDGDNCIEVAVTPQAVLVRDTKDREGGQLSVTPAAWADFVTFAKAVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDC4</accession>
    <name>A0A0F7NDC4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pseudouridine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_01625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019712.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_01625"/>
    <dbReference type="EnsemblBacteria" id="AKH86490">
        <property type="protein sequence ID" value="AKH86490"/>
        <property type="gene ID" value="AA958_01625"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_01625"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.357"/>
    <dbReference type="OrthoDB" id="1714699at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140098">
        <property type="term" value="F:catalytic activity, acting on RNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034470">
        <property type="term" value="P:ncRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02869">
        <property type="entry name" value="PseudoU_synth_RluA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PseudoU_synth_2" evidence="1">
        <location>
            <begin position="21"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="263" mass="28956" checksum="AE0F0B678D8BEC0F" modified="2015-07-22" version="1">MTVPSWREVRDSSVLLEDESVLVLNKPAGISVMGERHGTDLVELAAEAGEQLYPAHRVDKVTSGVILFAKDLATHGGLTRQFNKRTVDKAYLVVTATTGLPDRGTIELPLGVGRKNRVRIAAAREAIRADEADGRWWVAEEDVLDGKNYPSITHFRTLWSDNGHSVLIARPVTGRRHQIRVHLAWIGHPILGDPLFDKAAAAAGLRTHLHSWRLGFDASWRDGSRVDVVAEPDGGFWEPLAGTLTPDAIDRLLREGARLLRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDS0</accession>
    <name>A0A0F7NDS0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD-dependent deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_28575</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
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            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="444103.AA958_28575"/>
    <dbReference type="EnsemblBacteria" id="AKH85543">
        <property type="protein sequence ID" value="AKH85543"/>
        <property type="gene ID" value="AA958_28575"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_28575"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6020"/>
    <dbReference type="OrthoDB" id="1264438at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH85543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="247" mass="26283" checksum="F8F0FAABD26352D8" modified="2015-07-22" version="1">MSATTESTGRRPLVAILSGAGISTDSGIPDYRGPNGVWRRDPEAQKLVTYDYYMADPEIRRRSWQMRRANRTLLAEPNAAHLAVADLERAGVPVRVLTQNVDGLHQRAGMPDRKILELHGSARSFVCTNCAARGPMADALARVEAGEADPPCLECGGILKSATVMFGERLDPAVLGEAAAIAEACEVFLAVGTSLQVRPAAGLAGLAADHGARLIVVNAEPTPYDTRAAEVVREPISEALPPLLARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NE51</accession>
    <name>A0A0F7NE51_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sugar ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_29870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018962.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_29870"/>
    <dbReference type="EnsemblBacteria" id="AKH85734">
        <property type="protein sequence ID" value="AKH85734"/>
        <property type="gene ID" value="AA958_29870"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_29870"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6308"/>
    <dbReference type="OrthoDB" id="480174at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519443" evidence="1">
        <location>
            <begin position="26"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="420" mass="44563" checksum="BB897B8733BCBD36" modified="2015-07-22" version="1">MKRPALWSVVLAAGLLSGCGSAGSGSSSGTADGTLVVWDWKSGEETAASYIEQAKADFAAQHPDVKVEFVAQPFDQYYTLLGTAIQAGKGPDVMLFNGGGQIRDRADALLPLDEYVTGDRQRLAGWEAFTAKGKTYAAPVTLQGHPLYYNKALYEEAGLDPDRPATTWREFTDDCEAITEATDASCLSLGNKEGFGIQFFLSGLGPGVLTPREYDAWIAGDRDWNSPRVRRIFELWKETGDTGLNNEGANSTALFNDAFALFQSGKAAHVVGLMSDVGHWKDFGEFLDPDDIGVMQAPRAEAGAEPVLPYDGGIGYAVAKWTKKPALAADLVRSLTSKDALQAFYADAGAVVSDTTVDVSDGGAALSAITSEIGAGRPALHVALSTETLDLMGRLSQQILSGSTGVDEALEQLADSDRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NE78</accession>
    <name>A0A0F7NE78_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type III effector protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_04670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019781.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_04670"/>
    <dbReference type="EnsemblBacteria" id="AKH86546">
        <property type="protein sequence ID" value="AKH86546"/>
        <property type="gene ID" value="AA958_04670"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_04670"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.984"/>
    <dbReference type="OrthoDB" id="1801479at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="209" mass="21939" checksum="6D2606E9433B826B" modified="2015-07-22" version="1">MTAADEPSLTSTNAQSPASFLAAAAALHAIDDAVRGAQRESPDAPDAPGPGPEQALASLVLLRQVREQLAGWETGLIETARDAGASWADLAHPLGVASRQAAERRYLRGRPGPAGTTGEQRVQATRERRAAERTVAAWARDHAADLRRIAGQIAALTDLPATARLPLSRLHAALAQDDPAELVRPLAATRPHLTAHPGLTAQLDDLTPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NE99</accession>
    <name>A0A0F7NE99_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Universal stress protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_30175</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019007.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH85779">
        <property type="protein sequence ID" value="AKH85779"/>
        <property type="gene ID" value="AA958_30175"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_30175"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6372"/>
    <dbReference type="OrthoDB" id="2040681at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="3"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="151"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH85779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="290" mass="30923" checksum="42286E3544BC14D2" modified="2015-07-22" version="1">MEHPVVVGTDGSLHSLRAIDLAADEAARHGVPLRVVFASLWERYESMVPDIRGGERPPFEILADDIAGSGEERARRRQPDLKVTSRVLSDEPDTALTEESHQAFAVVTGSRGRGGAASLLLGSVSLAVAARATCPVIVVRGDEETWDDRSRPVVLGVSELAEGQAATEFAFREAAARHSPLLAVRAWRCPVFEPGGHLGHGSVALYEEKASAVVSDVLDEPRRTHPDVGVQRRLAEGPAHHVLMGASAEAGLVVLGAPRRRGHAGLQLGRVTHALLHSSTCPVAVVPERH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NES2</accession>
    <name>A0A0F7NES2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_21035</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020284.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_21035"/>
    <dbReference type="EnsemblBacteria" id="AKH86935">
        <property type="protein sequence ID" value="AKH86935"/>
        <property type="gene ID" value="AA958_21035"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_21035"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4430"/>
    <dbReference type="OrthoDB" id="1542347at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029046">
        <property type="entry name" value="LolA/LolB/LppX"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89392">
        <property type="entry name" value="SSF89392"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519374" evidence="2">
        <location>
            <begin position="22"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH86935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="299" mass="31621" checksum="1322CB1AC79471B0" modified="2015-07-22" version="1">MHTTVKRASVSLGAALLLAFAAACGSDSGGGDGGSGNGGGDGGGNGGSGTIRGAQAALKAIDEKTSGAESSKFESTMVMGEAMTTENEGELDWADGAIGTATVKYTDGQMASSIQMMDDDGTLDARYLPDAYYAGVEGAFQTQYPDKKWIRYDYDDLSEFMGPSGDYMKDQMQNSTPGQAVKLLLASEDVEEVGEEEVRGVQTTHYSGTVDVSDLARASSKTLSEQQLSDLEDQLEASGVTTQTVDIWVDENDLMIKREESGKMTGGEFSTTVYYSDYGVDVNVEEPSAAESIDFTEIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NET8</accession>
    <name>A0A0F7NET8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_21840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020311.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_21840"/>
    <dbReference type="EnsemblBacteria" id="AKH86955">
        <property type="protein sequence ID" value="AKH86955"/>
        <property type="gene ID" value="AA958_21840"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_21840"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4599"/>
    <dbReference type="OrthoDB" id="1312040at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="237" mass="24255" checksum="F842F6673B830134" modified="2015-07-22" version="1">MDVEGVVAGVMGRVAGEPVPVAGWRARVRRRVRGRRRVLLAGFAAVLVGLVLAAPVRAGVASFFDFGGVAVRTAPSSAPSGPGAPPPGAVPGCGALTLDAAARRAGFRPPVPPRLGAPDAAGVSADGRMVSLCWAAGRGAGGDAVRLDAFRGTLDPLVGKTSPVPPEWEQVGTGTALWFPEAHRLELLLRAPGGSTYTRTVRTAGPTLLWQGPDGLTLRLEGVPAKQEALRLAESVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NEW9</accession>
    <name>A0A0F7NEW9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_23600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020356.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_23600"/>
    <dbReference type="EnsemblBacteria" id="AKH86990">
        <property type="protein sequence ID" value="AKH86990"/>
        <property type="gene ID" value="AA958_23600"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_23600"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4974"/>
    <dbReference type="OrthoDB" id="1090356at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026555">
        <property type="entry name" value="NSL3/Tex30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13136">
        <property type="entry name" value="PTHR13136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH86990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="210" mass="21579" checksum="050A7A64508430F1" modified="2015-07-22" version="1">MKPTTQTVATPPGDARITWHRAARPRLVLALSHGAGGGIEARDLRALAGALPAEGVTVALVEQPWRVAGRKLAPAPKTLDAGWTALWPALEKPGLPVVAGGRSAGARVACRTARDLGALAVLALAFPLHPPGKPEKSRLAELLDAGVPTRVVQGERDPFGVPAEFPAEVDVVPVPYADHGFAVARSAPPDEAGTAATITAAAADWLAGLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NF87</accession>
    <name>A0A0F7NF87_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Arylsulfatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_32325</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="PTM">
        <text evidence="3">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019361.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_32325"/>
    <dbReference type="EnsemblBacteria" id="AKH86134">
        <property type="protein sequence ID" value="AKH86134"/>
        <property type="gene ID" value="AA958_32325"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_32325"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6824"/>
    <dbReference type="OrthoDB" id="1067869at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00149">
        <property type="entry name" value="SULFATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase" evidence="4">
        <location>
            <begin position="6"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="3">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600917-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH86134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="465" mass="51567" checksum="AC46E90C8C5FC3C6" modified="2015-07-22" version="1">MPDRRPHVIVVFTDQQRWDTTGAGGNPLDLTPAFDRMARSGTYASAAITPQPVCAPARAALQTGRWPTGTGCYRNGIPLPRDARTLAHHFGDAGYTTGYIGKWHLAGEDPVPPEDRGGYQHWLASNVLEFTSDAYRTVMYDEDGDPVRLPGYRSDALFDAAIRFAADHHEEPFFLFLSLIEPHHQNEVDDYPAPDGYEERYTGRWLPPDLAALSAEGGTAHRHIAGYCGQIRRVDEGLGRLLDALRSMDLLDDTIVAFTSDHGSHFRTRNSEYKRSCHDGSIRVPLALHGPGFAGGRVLDAPVSTLDLPPTLLDAAGLDVPEEMHGRSFLPLVRDPDADWPEDVFVQVSESECGRALRTSRWKYYVVDPAADGWRTRSGSRYVETALYDLAHDPYELDNLVGLASHRALADGLRARLLARITAAGEPEPVIEAAPERRAMQRRVDPTVHGFKLDGVRFGHQRKHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFC7</accession>
    <name>A0A0F7NFC7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_31735</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_31735"/>
    <dbReference type="EnsemblBacteria" id="AKH87180">
        <property type="protein sequence ID" value="AKH87180"/>
        <property type="gene ID" value="AA958_31735"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_31735"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6701"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="2">
        <location>
            <begin position="5"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="3">
        <location>
            <begin position="140"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH87180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="398" mass="43017" checksum="2FA1B8069CC66DAA" modified="2015-07-22" version="1">MTDLRLGVVGLGLRGNLADAAHRPGVGSVVAAVADTDPVVRAGVGARFPGAVAYADHRRLLDAADADGVDAIVVTTPDDTHATVARAALEAGKPVFVEKPLGITVEQCDAILRTAYETGTPLYVGDTMRHTGVVRLMRDIVARGDIGVPRTVWVRHFVAYGGDYYFKDWHADRRRTTGLLVQKAAHDIDVVHWLAGGYTSRVHALGALMLYGDLPRRPPGTPRPAGRHREDTWPPAARRDLNPVVDVEDVSVMNMRLDNGVIAAYQQCHFSPDYWRSYTVIGTEGRLENFGDRPGDEVRVWHTGPSGYRPGADAIHRVPAGEGAHGRADDRVIAEFCRFVRLGDATDTSPLAARMSVAAGVLATRSLRTGGTAYDVPPPDPALAEYFAAGQRRPAHQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFK3</accession>
    <name>A0A0F7NFK3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_28235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018716.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_28235"/>
    <dbReference type="EnsemblBacteria" id="AKH85482">
        <property type="protein sequence ID" value="AKH85482"/>
        <property type="gene ID" value="AA958_28235"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_28235"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5951"/>
    <dbReference type="OrthoDB" id="1465613at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="8"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="369" mass="37910" checksum="ACA08F2A4DC3A08B" modified="2015-07-22" version="1">MTAGEPLGVAVVGCGTISDQYLTNLTAFPDLRVLFCADLDAERAAAQAAAYGVPAHGSTEDALAHPGVELVVNLTLPAAHHDVAAAAIGAGKHVWNEKPLTLDPVSGAGLVTRAAGAGVRLGCAPDTFLGAGLQTARRLVDDGAIGVPLSGLALLQTPGPESWHPSPEFYFLRGGGPLFDMGPYYLTCLATLFGPARRVAAVASRARETRVVGSGPKAGTEFPVEVPTHVAALLDYAAGQTASLVVSFDSPLNRQGFVEITGTEATLALPDPNRFDGSLRLRPTGSAEWTEIEAAGATAGRGMGVLDMARALAAGEPHRASGELAQHVLETMAAVEKSARDGEFVPVAGAGFTVPAALPADWDPGVRMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFZ6</accession>
    <name>A0A0F7NFZ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Siderophore biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_33080</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019480.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_33080"/>
    <dbReference type="EnsemblBacteria" id="AKH86253">
        <property type="protein sequence ID" value="AKH86253"/>
        <property type="gene ID" value="AA958_33080"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_33080"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6988"/>
    <dbReference type="OrthoDB" id="1677960at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="2">
        <location>
            <begin position="111"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH86253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="393" mass="42438" checksum="CE1D6B5B53392877" modified="2015-07-22" version="1">MRLYLLARNPTDSVTDGFLPAARRLGLTVTVLTDQPAAHRLRAPEPETLGCDVRDFRAVIGRISAHHRPDAVFTNSDHLQTQAALAAGYFGLPAKNWRAAHATKDKAEMRRRLAAAGAEPVWAAELPAGADPAALYAPYPCVVKPREGVASEDVVLAADAAELVRRCAEIRARRPGEALVVEEFLAGELYTLETLGDGRVRHLLGGFHTELSPPPHFVEEHMSYVPTHPGPVTAQVLGQLDALGVGFGACHTEFVVSGGRARLVEVNYRAIGDQCDLLLARLLGIPLFAHILRTHLGEPLPADLGARTDGRARLSYPCARTAGTLTAAPGPADLVVDGVEVTYRPLRAVGERHALHRTNRDFLGVARGIGTDQRRVDRAVADFLAAQRWEITP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-12-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NG06</accession>
    <name>A0A0F7NG06_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PadR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_33130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86263">
        <property type="protein sequence ID" value="AKH86263"/>
        <property type="gene ID" value="AA958_33130"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_33130"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6999"/>
    <dbReference type="OrthoDB" id="1706427at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="1">
        <location>
            <begin position="5"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="104" mass="11379" checksum="27F4137634470CED" modified="2015-07-22" version="1">MDGLLLAALEGGPLHGYAIITAVQQRSAGALELRTGTVYPALNRLERTGLLRSTWESVGERRRRCYELTDAGRRALADERTAWREFTSAIGSVLDPGRAPRPAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NGC1</accession>
    <name>A0A0F7NGC1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_01990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_01990"/>
    <dbReference type="EnsemblBacteria" id="AKH86499">
        <property type="protein sequence ID" value="AKH86499"/>
        <property type="gene ID" value="AA958_01990"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_01990"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.430"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005000">
        <property type="entry name" value="Aldolase/citrate-lyase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03328">
        <property type="entry name" value="HpcH_HpaI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HpcH_HpaI" evidence="1">
        <location>
            <begin position="189"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="440" mass="45078" checksum="DF5C90A442D70BB1" modified="2015-07-22" version="1">MAQDDPAATSIGAPVRARIAAALAPVDAELARRYPGDPGTRQPVHTVYVPADAFGAGTVTEWGRQALDALDAHAPDAGVLAAALGLPAGAAAEVYDRVRAKLAREPVEDLRVDFEDGYGPRPDDEEDAAAVAAARLVAEAAAGGGAPPYAGIRAKCLEAAVRDRGIRTLDLFLTALLRAGGGTLPDGLVLTLPKVTYPEQVSAMAALLGEFERVHGLAAGRLGFEIQIETTQAILGADGRATVARMIDAAGGRATGLHYGTFDYSAACGVSAAHQSMDHPVADHAKAVMQAAAAGTGVRLSDGSTNVLPVGGTAQVHAAWRLHYGLVRRSLARAYYQGWDMHPGHLPTRYAAVYAFCREGLDAACARLTAYAGRLGGTEGGAGAGAGAGAVLDEPATARALSGFLLRGLDCGAVDEAEVADRTGLGRTELDALAGRPPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NGM8</accession>
    <name>A0A0F7NGM8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_30840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019110.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_30840"/>
    <dbReference type="EnsemblBacteria" id="AKH85882">
        <property type="protein sequence ID" value="AKH85882"/>
        <property type="gene ID" value="AA958_30840"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_30840"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6518"/>
    <dbReference type="OrthoDB" id="1003984at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="51"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="299" mass="32915" checksum="813BE2E1AC93CB00" modified="2015-07-22" version="1">MVFVEVPLTAAVREATGVTGFAERLYGGEESAAWRVGAHVVRIGAYDKDTAETEWCHRVAVAAQTGGCPEAVAPLPIPGRDGATVVRVEGRTVSLWPYVDGVWADGDDPRSATAAARMLARLHRALAGARLPPRPRRNFLEAGLAGDEAYNDPRLHDPQLDTWLAGFTARALPRHALHGDYYHGNLLVDRGDPARIVAVLDWDESFVAPPEVEVGGAALEFADEFCENPADARRFADAYREAGGTAEALDEETLTQLMRHRLRREGAYFALAVARGVRHDEEDLEYHRRRMEAFARLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NH27</accession>
    <name>A0A0F7NH27_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sugar ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_13360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020023.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_13360"/>
    <dbReference type="EnsemblBacteria" id="AKH86739">
        <property type="protein sequence ID" value="AKH86739"/>
        <property type="gene ID" value="AA958_13360"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_13360"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2810"/>
    <dbReference type="OrthoDB" id="1746871at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="435"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="460" mass="48636" checksum="5ADF89D5DFCD7BF6" modified="2015-07-22" version="1">MPAALAAGLAVIAAGCVPGTDGSGAVDGGGAGGAGGVPDPAKAGNVTLTVWDQEVRGGTNAELEQLNKEFQEKYPNVKIKRVSRSFDDLKTTLKLALSGNKPPDIVQANQGYPDMVAFVQAGLLMPLDNYAGVYDWNTRYPNTLLNLNRVSADGKQFGTGRLYGISQTGEFIGVYYNKEKLADAGIEPPKTWKEFTDSLATLKDEGELPIQFGNLDQWPAIHNFGVLHDQHGAAEARDTVLGRGDGFDNAYTKDAAAELADWIDKGYLPKDANGRGYDDSYKQFADGEGGYLIAGTWLQADLKKPMGDNLGVMAPPPASEGGNPTTTGGQGLSWSVTSKSAHPDVAAAYLDFITDEHAADVMTENGVLPAVPGKAADEVDPDSPDGQMIAAWKRLNADDALVPYLDYSTPTFYDTVSAGLQDLIAGKTSPDGFAKKLQDDYGPFMEKQRGDGAGSEPAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NHI5</accession>
    <name>A0A0F7NHI5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_14645</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020058.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86768">
        <property type="protein sequence ID" value="AKH86768"/>
        <property type="gene ID" value="AA958_14645"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_14645"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3085"/>
    <dbReference type="OrthoDB" id="1983082at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH86768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="173" mass="19024" checksum="FBC49FFA82818A7D" modified="2015-07-22" version="1">MSRWQADTQREAVADVYVAAYNGAVGGAAPEREGFLRRLEDHVQRPGFEMVLAGGDRPVGCAYGFRADRSGVWWPDFPEGPPLALAEVTSSPRAFVVAELMVVPDQRRRHIATRLQQHLLARWAPSPAVALLPQDNAAAGAAYETWGWTRTGSLHPVPPTPPLDLWTHRRPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NI16</accession>
    <name>A0A0F7NI16_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase M23</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_28815</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020489.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_28815"/>
    <dbReference type="EnsemblBacteria" id="AKH87094">
        <property type="protein sequence ID" value="AKH87094"/>
        <property type="gene ID" value="AA958_28815"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_28815"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6072"/>
    <dbReference type="OrthoDB" id="1891666at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519520" evidence="1">
        <location>
            <begin position="21"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M23" evidence="2">
        <location>
            <begin position="78"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH87094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="186" mass="19855" checksum="ACF3692B2C438A4A" modified="2015-07-22" version="1">MFAAVSVAAAVAVATPVAVAAPQGATSSATAEPLARPAFRMPFICGQVWRGNNWSGHSPAHSIDWNHYNAQGTPDDLGRRVLASAGGEVVASYYSTGDGYGNTVVIAHGDGWRTRYAHLKERSVARGTQVKRGQVIGKVGATSAIYEFSPHLHYEQIHNGSVVVAVVQGVTWYDYLDRRLKSTNGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NIF0</accession>
    <name>A0A0F7NIF0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_33955</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020667.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_33955"/>
    <dbReference type="EnsemblBacteria" id="AKH87219">
        <property type="protein sequence ID" value="AKH87219"/>
        <property type="gene ID" value="AA958_33955"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_33955"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.7170"/>
    <dbReference type="OrthoDB" id="386120at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH87219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="320" mass="34919" checksum="0173EAB835855F2F" modified="2015-07-22" version="1">MVGGADPSVIRVGSLYVSAKSVDGGIAVRTASTPEAVATAPKHQVWQDTANLGEVWAPEIVHHDGQYRIYFAAGRGAAHRMYHIGSPNPTSGYSAAVKVALPGDKWAIDGVPFTFGGQRWFVWSGWAGDTNVEQNLYVARMSSPTASTGGRYIISQPREPWERVVGNPYINEAPQPIVDPDGQLHVVYSANGSWSDKYCIADLRLRAGGDPTYVWDWYKSNGCLFGSHAPSMMSGWTPTVNVNGPGHHTFILPQGDVNAGPPSGNRFPTMFHAVAKGTPYTWSNRFWYSGTAVWWSNTTYRRANVPGSTTNVGYSLKFFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NJS5</accession>
    <name>A0A0F7NJS5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Formamidopyrimidine-DNA glycosylase</fullName>
            <shortName evidence="15">Fapy-DNA glycosylase</shortName>
            <ecNumber evidence="15">3.2.2.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">DNA-(apurinic or apyrimidinic site) lyase MutM</fullName>
            <shortName evidence="15">AP lyase MutM</shortName>
            <ecNumber evidence="15">4.2.99.18</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">mutM</name>
        <name evidence="15" type="synonym">fpg</name>
        <name evidence="19" type="ORF">AA958_25850</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>Hydrolysis of DNA containing ring-opened 7-methylguanine residues, releasing 2,6-diamino-4-hydroxy-5-(N-methyl)formamidopyrimidine.</text>
            <dbReference type="EC" id="3.2.2.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="15">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 15">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the FPG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.23" evidence="15"/>
    <dbReference type="EC" id="4.2.99.18" evidence="15"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020414.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_25850"/>
    <dbReference type="EnsemblBacteria" id="AKH87037">
        <property type="protein sequence ID" value="AKH87037"/>
        <property type="gene ID" value="AA958_25850"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_25850"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5444"/>
    <dbReference type="OrthoDB" id="1162346at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008534">
        <property type="term" value="F:oxidized purine nucleobase lesion DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00103">
        <property type="entry name" value="Fapy_DNA_glycosyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015886">
        <property type="entry name" value="DNA_glyclase/AP_lyase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015887">
        <property type="entry name" value="DNA_glyclase_Znf_dom_DNA_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020629">
        <property type="entry name" value="Formamido-pyr_DNA_Glyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012319">
        <property type="entry name" value="FPG_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035937">
        <property type="entry name" value="MutM-like_N-ter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_S13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000214">
        <property type="entry name" value="Znf_DNA_glyclase/AP_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010663">
        <property type="entry name" value="Znf_FPG/IleRS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01149">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06831">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06827">
        <property type="entry name" value="zf-FPG_IleRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00898">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01232">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="SSF46946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81624">
        <property type="entry name" value="SSF81624"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00577">
        <property type="entry name" value="fpg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51068">
        <property type="entry name" value="FPG_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01242">
        <property type="entry name" value="ZF_FPG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51066">
        <property type="entry name" value="ZF_FPG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 15" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10 15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9 15" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="13 15" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 15" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 15" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 15" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 15 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FPG_CAT" evidence="18">
        <location>
            <begin position="2"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="FPG-type" evidence="17">
        <location>
            <begin position="246"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with DNA" evidence="15">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="15">
        <location>
            <position position="3"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for beta-elimination activity" evidence="15">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for delta-elimination activity" evidence="15">
        <location>
            <position position="270"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>DNA</name>
            <dbReference type="ChEBI" id="CHEBI:16991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>DNA</name>
            <dbReference type="ChEBI" id="CHEBI:16991"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00024490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="AKH87037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="284" mass="31611" checksum="54BFFA1180F4E7CB" modified="2015-07-22" version="1">MPELPEVEVVRRGLAKWVAGRTVGSVEVLHPRSVRRHPAGAGDFAARLTGHPLGEPRRRGKYLWLPLADGPESVLAHLGMSGQLLVRPEAAPDEKHLRIRVRFADETDTELRFVDQRTFGGLSLHPNAAGGLPDVIAHIARDPLDPEFDDAAFHAALRRSRTTIKRALLNQSLISGVGNIYADEALWRARLHYERPTAGLTRPRTAELLGHVRAVLNAALDVGGTSFDSLYVNVNGESGYFARSLDAYGREDEPCRRCGTPIRRRPWMNRSSYFCPRCQRPPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MYX6</accession>
    <name>A0A0F7MYX6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_03875</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014827.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_03875"/>
    <dbReference type="EnsemblBacteria" id="AKH81470">
        <property type="protein sequence ID" value="AKH81470"/>
        <property type="gene ID" value="AA958_03875"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_03875"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.814"/>
    <dbReference type="OrthoDB" id="750230at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="3">
        <location>
            <begin position="18"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="292"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH81470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="314" mass="32292" checksum="0993EE95CA17EA89" modified="2015-07-22" version="1">MSAYEAAGEPESLARRVPDLAALELLLAVARLGSLGRAAKAVGVSQPAASARIRSMERQLGVALVHRSPAGSRLTEAGGVVTEWARRVVEAAEAFDAGAAALRARRDSRLRVAASLTVAEYLLPGWLVALRAARPETAVSLQAGNSVAVASQVRSGAADLGFVEGPGVPSGLDGAVIGRDRLLVVVAPSHPWARRRRGLPPGELASAALVLREQGSGTRQVLDEALGPYGGLGTPLLELASTTAVKSAAVTGAGPAVLSELAVADEVATRRLVAVAVTGLPLTRALRAVWPRGQRPTGPARDLLSLTRRGERAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MYZ1</accession>
    <name>A0A0F7MYZ1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA (adenine(58)-N(1))-methyltransferase TrmI</fullName>
            <ecNumber evidence="4">2.1.1.220</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_04025</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>adenosine(58) in tRNA + S-adenosyl-L-methionine = H(+) + N(1)-methyladenosine(58) in tRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:43152"/>
            <dbReference type="Rhea" id="RHEA-COMP:10365"/>
            <dbReference type="Rhea" id="RHEA-COMP:10366"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74491"/>
            <dbReference type="EC" id="2.1.1.220"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer composed of a dimer of dimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.220" evidence="4"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014850.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_04025"/>
    <dbReference type="EnsemblBacteria" id="AKH81495">
        <property type="protein sequence ID" value="AKH81495"/>
        <property type="gene ID" value="AA958_04025"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_04025"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.844"/>
    <dbReference type="OrthoDB" id="944891at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031515">
        <property type="term" value="C:tRNA (m1A) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016429">
        <property type="term" value="F:tRNA (adenine-N1-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014816">
        <property type="entry name" value="tRNA_MeTrfase_Gcd14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12133">
        <property type="entry name" value="PTHR12133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08704">
        <property type="entry name" value="GCD14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017269">
        <property type="entry name" value="GCD14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51620">
        <property type="entry name" value="SAM_TRM61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="5">
        <location>
            <begin position="117"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="272"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR017269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR017269-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH81495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="301" mass="32738" checksum="12CDA5C1589A8EF9" modified="2015-07-22" version="1">MSEPTGAARRRGPFQVGDQVQLTDPKGRHYTFTLEAGKSFHTHKGSFPHDELIDAPEGTVVRTTGNVPYLALRPLLPDYVLSMPRGAAVVYPKDAGQILAFADVFPGARVVEAGVGSGSLTSFLLRAVGDSGMLHSYERRADFADVARQNVERYFGGPHPAWQLTVGDLQDNLSDTGVDRVILDMLAPWECLDAVAKALVPGGIVCAYVATTTQLARTVESIREHGNFNEPQAWETMLRNWHVEGLAVRPDHRMIGHTGFLLTARRLADGVEPPLRRRRPAKGAYGEDYTGPGGQRATAGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MZ04</accession>
    <name>A0A0F7MZ04_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Multidrug ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_04105</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014865.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_04105"/>
    <dbReference type="EnsemblBacteria" id="AKH81510">
        <property type="protein sequence ID" value="AKH81510"/>
        <property type="gene ID" value="AA958_04105"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_04105"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.862"/>
    <dbReference type="OrthoDB" id="551294at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="AAA+_ATPase"/>
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        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
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        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="9"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="262"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="503"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="512"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH81510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="550" mass="57665" checksum="A4D7B60D9F93E13C" modified="2015-07-22" version="1">MPAAPRPAVRADGVVKRFGPTLALDGVHLEVAAGEAHALVGRNGAGKSTLVSVLTGMERPDAGTVTFSGAPAPPFGDTAAWRAKVACVYQKLMIVPDLTVAENLFLNRYTGGGAINWRRLRSRARELLAAYGVEVDPSARAKDLGVEQRQFVEIARALSFGARLIILDEPTARLDAGGIDRLFGKLRELQRQGVAFLFISHHLQEVYELCDTVTVFRDARHILTAPVSGLPKEDLVAAMTGEGAPAGAGGPAALPRQATAASGAEPVLRAHALAVAGAYEPLDLAVRAGEVVGLAGAAASGNTVIGETLVGMRAPDGGRVEVRGTAVRTGSVPHALEAGIGYVPEDRHVQGLVPGRSVAENATLTVADQLGPYGTVLPSRTRRFAQRMIESLDIKTSGPAQDVDGLSGGNQQKVVIARALARDPGVLVAIKPTAGVDVKSKDALLGVVRRVADGGSGAVIVSDELDDLRVCDRVLALFHGRVIAEFGGGWTDRELVAAMEGIEPGARDPQQDHGTGTDQQDPHVQQDQHAQPDQSVEPDQRDQPEKGQQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MZE5</accession>
    <name>A0A0F7MZE5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tetratricopeptide TPR_4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_05005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015015.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_05005"/>
    <dbReference type="EnsemblBacteria" id="AKH81660">
        <property type="protein sequence ID" value="AKH81660"/>
        <property type="gene ID" value="AA958_05005"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_05005"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1052"/>
    <dbReference type="OrthoDB" id="1308416at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="281" mass="30804" checksum="588C88A32D88E2CA" modified="2015-07-22" version="1">MRRLSIPEDVTGLELDKAVRQELQSLPKTLADDVAKNLVMVARLLDEDAPRAYEHAKVALRLASRVGAVREAAGFAAYHTEKYQEALAEFRTARRMSGRPDLWPVMADCERGMGRPERALAMAGEPEVQRLDKAGQVEMRLVAAGARRDLGQPDAAVVTLQSPELASTAVHPWTARLRYAYADALLEVGREEDAREWFAKAVEADHEGLTDASDRLAELDGIEFTDALDPDSEEIEGDAADEVEEDAEAAAEVSGADFTDEDDPAVDDDEEEDEDGDEPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MZH6</accession>
    <name>A0A0F7MZH6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_05235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015054.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_05235"/>
    <dbReference type="EnsemblBacteria" id="AKH81700">
        <property type="protein sequence ID" value="AKH81700"/>
        <property type="gene ID" value="AA958_05235"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_05235"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1099"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="280" mass="27687" checksum="A0D49E550632C8E2" modified="2015-07-22" version="1">MTAGSWEQAVREQVGLGRLLPLGGAADGTWIAERAAAGVLRRAAAGVREARVTGLRVGLADPGDEEALHGRADARGGTGSVRDAMGTGAAGGDPRGGAARPAGRAAVRDAGGAGGEVHYLGPRAPGGAAAAGPAPVSALPYGELRISARCDATVDRPVTATAAALREALLRGAEERLGLRVAAVDVHVAGLLESPQTAAQPAPGGPPDPPPPAPAARETARSGNGAPDVPGVLDCDVLPDGEHAEVRVVLDSAHRALDVALAVRAGTGAATVTVLVTDIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MZU6</accession>
    <name>A0A0F7MZU6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">N-acetylmuramoyl-L-alanine amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_02480</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014589.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_02480"/>
    <dbReference type="EnsemblBacteria" id="AKH81226">
        <property type="protein sequence ID" value="AKH81226"/>
        <property type="gene ID" value="AA958_02480"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_02480"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.530"/>
    <dbReference type="OrthoDB" id="1584918at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06583">
        <property type="entry name" value="PGRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036505">
        <property type="entry name" value="Amidase/PGRP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002502">
        <property type="entry name" value="Amidase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01510">
        <property type="entry name" value="Amidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00644">
        <property type="entry name" value="Ami_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55846">
        <property type="entry name" value="SSF55846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519619" evidence="1">
        <location>
            <begin position="35"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetylmuramoyl-L-alanine amidase" evidence="2">
        <location>
            <begin position="50"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH81226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="195" mass="21698" checksum="9D885E3484B8F050" modified="2015-07-22" version="1">MDFANLPRRRLIQGAAATAAAAGLGGLAATPAQAAQYPPTHWIPADRSNYTVSSRPTAYPVDFVVVHVTQEYFQDAVDIFQNPSRDVSSHYLIASADGYIAQLVREKDIAWHAGNWNYNTRSIGIEHEGWVDKPAWFTDVMYRRSAQLTAAICTRYGIPRTRDRIIGHNEVPGATHTDPGPNWDWTKYMGLVRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-10-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N009</accession>
    <name>A0A0F7N009_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_06380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015248.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH81895">
        <property type="protein sequence ID" value="AKH81895"/>
        <property type="gene ID" value="AA958_06380"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_06380"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1332"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="54" mass="5469" checksum="30B92913F7BB598B" modified="2015-07-22" version="1">MNGLSILLIFVGLFLLGGVISFVKQGQSKNVIAVLAIGAAMALAAGVLRLGVWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N087</accession>
    <name>A0A0F7N087_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">3-dehydroquinate dehydratase</fullName>
            <shortName evidence="7">3-dehydroquinase</shortName>
            <ecNumber evidence="5 7">4.2.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Type II DHQase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">aroQ</name>
        <name evidence="11" type="ORF">AA958_03180</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes a trans-dehydration via an enolate intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>3-dehydroquinate = 3-dehydroshikimate + H2O</text>
            <dbReference type="Rhea" id="RHEA:21096"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16630"/>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
            <dbReference type="EC" id="4.2.1.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 3/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 7">Homododecamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the type-II 3-dehydroquinase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.10" evidence="5 7"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014705.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_03180"/>
    <dbReference type="EnsemblBacteria" id="AKH81346">
        <property type="protein sequence ID" value="AKH81346"/>
        <property type="gene ID" value="AA958_03180"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_03180"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.678"/>
    <dbReference type="OrthoDB" id="1872106at2"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00086"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003855">
        <property type="term" value="F:3-dehydroquinate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00466">
        <property type="entry name" value="DHQase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.9100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00169">
        <property type="entry name" value="AroQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001874">
        <property type="entry name" value="DHquinase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018509">
        <property type="entry name" value="DHquinase_II_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036441">
        <property type="entry name" value="DHquinase_II_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21272">
        <property type="entry name" value="PTHR21272"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01220">
        <property type="entry name" value="DHquinase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001399">
        <property type="entry name" value="DHquinase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52304">
        <property type="entry name" value="SSF52304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01088">
        <property type="entry name" value="aroQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01029">
        <property type="entry name" value="DEHYDROQUINASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="6 7 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="7 9">
        <location>
            <begin position="101"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7 8">
        <location>
            <position position="23"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7 8">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7 10">
        <location>
            <position position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001399-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001399-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001399-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AKH81346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="146" mass="15693" checksum="7D38D789B319E1B8" modified="2015-07-22" version="1">MTRVLVLNGPNLGRLGSREPDVYGATSYAGLVEQCTALGKELGFEVEVRETNDEGEMIRWLHEAADGRLPVVINPGAFTHYSYGMRDAAAQRTAPLIEVHISNPHAREVFRHTSVIAAVASGTIAGFGIGSYRLALRALAEDLASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0A6</accession>
    <name>A0A0F7N0A6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Multidrug MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_07230</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015400.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_07230"/>
    <dbReference type="EnsemblBacteria" id="AKH82050">
        <property type="protein sequence ID" value="AKH82050"/>
        <property type="gene ID" value="AA958_07230"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_07230"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1515"/>
    <dbReference type="OrthoDB" id="1108236at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="16"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="239"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="278"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="339"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="366"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="413"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="482"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="18"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH82050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="521" mass="54582" checksum="7D57B6A88035C4EB" modified="2015-07-22" version="1">MDTAHQIPPAVHRRRWFILGVLIFSLLIVVLDNSILNVAMKTIATPAPAGLGASQSELEWAIDAYTLAFAGLLFTAGVLGDRLGRKRVLLAGLVVFGVGSVLAAFSSSPAELIAFRTLMGLGGAFVLPATLAIIVNVFERDEQPRAIGIWAGAVGLAIAIGPITGGLLLEHFWWGSVFLVNVPIIGIALIGMVLLVPDSKDPDPGRLDPTGVLLSVAGLVLIVYGVVRGGQRADFGAPEVWGAILAGAVVVGLFIWYERRSRHPALDIRWFRNPRFSASVAVIGLVFFALMGVTFFMVFYIQSVRGLSPLDSGLLLLPLAIAQLIFAPRSRLVVDRFGARAVCTVAMLGIAVAFAGFLLLDETSPLWILEVLFFVMGTAMAHVMPPATTAIMQSLPREKAGAGSSVNNTFRQVGGALGVAVLGSLLSSVYRGKVTLPAGAPSAAGESIEATRTFAQKAGAAGKKLISEANNAFVDAMHVTSMAAAGAAVLGAVVAAAFMPAKDRGTQGPVRTGENEPSTRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0N3</accession>
    <name>A0A0F7N0N3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_04345</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 68 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_04345"/>
    <dbReference type="EnsemblBacteria" id="AKH81546">
        <property type="protein sequence ID" value="AKH81546"/>
        <property type="gene ID" value="AA958_04345"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_04345"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.913"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050053">
        <property type="term" value="F:levansucrase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009758">
        <property type="term" value="P:carbohydrate utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08997">
        <property type="entry name" value="GH68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003469">
        <property type="entry name" value="Glyco_hydro_68"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02435">
        <property type="entry name" value="Glyco_hydro_68"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="373"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH81546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="392" mass="42593" checksum="C02DFEE1706BA87A" modified="2015-07-22" version="1">MSGTRPTRWTRHHLDALVESPATTAPPAPATPRPRVLPHHDIWDAWPLQQSDGAPAVVHGAGLWMALSAPAAGHPEHRHDHARIRLLARSDERWDDLGHVFAAGTSLGSREWSGSAVIRPDGTVSVFYTAAGRAGESRPTFRQRIVEARPELLTGGQAVELEQGVEHREVLRSDGRSYEPADEFDGGPGRIRAFRDPSWFRDPADGREYLLVAASVPGPEGFMGAVAIARAASGGWGLLPPLLVADGVNHEIERPHVVVHRSRYYLFFCTTRRSFHPAGSAPTGLYGFVAPTLWGPYEPLNRSGLVIQNPPAQPDQAYAWLVLSSLRVTSFLNYRSANGKDPAQAGPDEARAGFGGTFAPMLDLALEGTSTRVLRAPREEEWTAGDQPHPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0U9</accession>
    <name>A0A0F7N0U9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sulfatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_01320</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="PTM">
        <text evidence="3">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014393.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_01320"/>
    <dbReference type="EnsemblBacteria" id="AKH81028">
        <property type="protein sequence ID" value="AKH81028"/>
        <property type="gene ID" value="AA958_01320"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_01320"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.292"/>
    <dbReference type="OrthoDB" id="1067869at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032506">
        <property type="entry name" value="DUF4976"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16347">
        <property type="entry name" value="DUF4976"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00149">
        <property type="entry name" value="SULFATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase" evidence="4">
        <location>
            <begin position="7"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4976" evidence="5">
        <location>
            <begin position="354"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="3">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600917-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH81028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="478" mass="53250" checksum="BA91B815C1F68658" modified="2015-07-22" version="1">MTPPRRPNIILFMTDDHAPAAISAYGSVINKTPAVDRLAAEGTVFENAYCTNAICSPARATLLTGTYSHVNGMTSLESPTHRFDAAQPSFPGMLQHAGYQTAIVGKWHLGHGAGHDPRGFDYWEILPEHGVYHDPEFLTAGGRRTYPGYVTDIITDLALNWLDKRDPDKPFCLLVQHKAPHRAFEPAERHACLYEHEDVPAPPTLHDDLAGRAPAAREARMSMEDLTSEDLKGVPVPPGMPPPEEREWRYQRYIKDYLRVIAALDENVGRVLHYLDVSGLDGATAVAYTSDHGFFLGEHGWFDKRFMYEEGIRIPLVVRWPGRTAAGSRRRELVANVDFAPTLLDLAGVAPHPRMQGESLVPLLRGEEPARWRDAVYYRYYMHLDDCHNVQASYGLRTATHKLIHYPGHGSGAAGAEDDPRPAAWELFDLTTDPHELHNLYDDPRCADVVRDLTVRLATLQRDVGDTPDGHLPEGAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0V7</accession>
    <name>A0A0F7N0V7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome c oxidase subunit 1</fullName>
            <ecNumber evidence="9">7.1.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AA958_04840</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 9">Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 9">
            <text>4 Fe(II)-[cytochrome c] + 8 H(+)(in) + O2 = 4 Fe(III)-[cytochrome c] + 4 H(+)(out) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11436"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="7.1.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the heme-copper respiratory oxidase family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.9" evidence="9"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_04840"/>
    <dbReference type="EnsemblBacteria" id="AKH81631">
        <property type="protein sequence ID" value="AKH81631"/>
        <property type="gene ID" value="AA958_04840"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_04840"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1019"/>
    <dbReference type="OrthoDB" id="316745at2"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070469">
        <property type="term" value="C:respirasome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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    </dbReference>
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        <property type="entry name" value="CYCOXIDASEI"/>
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        <property type="match status" value="1"/>
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    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="9" id="KW-0186">Copper</keyword>
    <keyword evidence="8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="17"/>
            <end position="37"/>
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    <feature type="transmembrane region" description="Helical" evidence="9">
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            <end position="426"/>
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    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="446"/>
            <end position="470"/>
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    </feature>
    <feature type="domain" description="COX1" evidence="11">
        <location>
            <begin position="1"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
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            <begin position="513"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="523"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU363061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AKH81631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="547" mass="61090" checksum="0AB905F3C5E09E14" modified="2015-07-22" version="1">MVVDWLTTTDHKKIGHLYLITSFAFFLFAGLLAMVMRAELARPGMQILSHEQFNQSFTIHGTIMLLLFATPTFAGFANEIMPLQIGAPDVAFPRLNMLSYWLFLFGGLIVLSSYLTPSGPADFGWFAYAPLNGPVHSPGVGADLWIMGLALAGFGTILGAVNFLTTIVTMRAPGMTMFRMPIFTWNTLFTSILVLMAFPVLAAALLVLESDRRFGSVVFDGSVGGALLWQHLFWFFGHPEVYIIALPFFGIISEIIPVFSRKPIFGYVMLVAATVAITGLSIMVWAHHMFATGAVLLPYFSLASFLIAVPTGVKFFNWIGTMVNGSLSFETPMLWSIGFLVSFLFGGLTGVLLASPPLDFHVTDTYFVVGHFHYVVFGTVVFATFAGFYFWWPKFTGKMLDERLGRIHFWTLFVGFHATFLVHHWLGVEGMPRRYADYLDADGFTTLNTISTIGAFLLGASTLPFLYNLWHTAKEGEKVDVDDPWGFGRSLEWATSCPPPRHNFKTLPPIRSESPAFDLHHPYALATERRDETDQRNRRDEQGAREP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N110</accession>
    <name>A0A0F7N110_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">GTP 3',8-cyclase</fullName>
            <ecNumber evidence="3 12">4.1.99.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Molybdenum cofactor biosynthesis protein A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">moaA</name>
        <name evidence="14" type="ORF">AA958_05160</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>AH2 + GTP + S-adenosyl-L-methionine = (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate + 5'-deoxyadenosine + A + H(+) + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:49576"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:131766"/>
            <dbReference type="EC" id="4.1.99.22"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="12">Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Monomer and homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the radical SAM superfamily. MoaA family.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.22" evidence="3 12"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015041.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_05160"/>
    <dbReference type="EnsemblBacteria" id="AKH81686">
        <property type="protein sequence ID" value="AKH81686"/>
        <property type="gene ID" value="AA958_05160"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_05160"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1084"/>
    <dbReference type="OrthoDB" id="1199289at2"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019008">
        <property type="term" value="C:molybdopterin synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061798">
        <property type="term" value="F:GTP 3',8'-cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904047">
        <property type="term" value="F:S-adenosyl-L-methionine binding"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01225_B">
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013483">
        <property type="entry name" value="MoaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000385">
        <property type="entry name" value="MoaA_NifB_PqqE_Fe-S-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010505">
        <property type="entry name" value="Mob_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06463">
        <property type="entry name" value="Mob_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02666">
        <property type="entry name" value="moaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01305">
        <property type="entry name" value="MOAA_NIFB_PQQE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9 12" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7 12" id="KW-0408">Iron</keyword>
    <keyword evidence="8 12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="11 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 12" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="13">
        <location>
            <begin position="5"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-substrate</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-substrate</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="261"/>
            <end position="263"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-substrate</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AKH81686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="329" mass="35947" checksum="D85E134038DAC622" modified="2015-07-22" version="1">MLRDTYGRVATDLRVSLTDRCNLRCTYCMPEEGLQWLGKPELLTDDEIVRLVRLAVTEFGVTDVRFTGGEPLLRPGLTGIVERCAALTPRPKLSLTTNGIGLERTAAALKAAGLDRVNVSLDTLSADVFQRLTRRKRHGDVLRGLAAARAAGLDPVKVNSVLMPGFNEDEAPDLLAWAVAEGYELRFIEQMPLDPQHGWQRDGMITAGDILTSLRTRFTLTPEGEAVRGSAPAERWLVDGGPARVGVIASVTRPFCRACDRTRLTADGQVRNCLFAREETDLRGALRSGAPDEEIARLWRIAMWGKKAGAGLDDPSFVQPDRPMSAIGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N117</accession>
    <name>A0A0F7N117_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_01735</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014462.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_01735"/>
    <dbReference type="EnsemblBacteria" id="AKH81098">
        <property type="protein sequence ID" value="AKH81098"/>
        <property type="gene ID" value="AA958_01735"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_01735"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.379"/>
    <dbReference type="OrthoDB" id="1487105at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="179"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH81098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="268" mass="28644" checksum="4B569E548645929F" modified="2015-07-22" version="1">MGDGRLTLTMVDTARVPPLLALAALVVTFLVTRGVTRMIRAGRGPFRDVDPGGMHIHHVVPGVVLMVIGGFGAVFVEGGVVAESVVAVVFGVGTGLVLDEFALIVHLHDVYWSEQGRASVEVTVLTAVVVGMVLIGSSPFDVDDQGGLQEQGVLLWSVNIVVGALIAVVSFAKGKFRMGVLGVVIPLVGAVGAIRLARPASPWAHRFYARRPHKLARATRRAARHDARWSGLRTRFQNAIAGAPSRPQQQGPDRDRDRDRDDSPPPPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N166</accession>
    <name>A0A0F7N166_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_01850</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014483.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_01850"/>
    <dbReference type="EnsemblBacteria" id="AKH81119">
        <property type="protein sequence ID" value="AKH81119"/>
        <property type="gene ID" value="AA958_01850"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_01850"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.402"/>
    <dbReference type="OrthoDB" id="2068436at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018649">
        <property type="entry name" value="SHOCT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09851">
        <property type="entry name" value="SHOCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="SHOCT" evidence="2">
        <location>
            <begin position="66"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH81119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="106" mass="11653" checksum="4DC3F82D022896E9" modified="2015-07-22" version="1">MNTLAHWNDGGPGPWILLFPLMWALVLGGLFFFVRRVVRRGRGAPWQRFRGGPGGPGGPGYGEQSPIAVLGRRFAAGEIDEDEYWRRLSVLNEVFGRRGESKGGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N170</accession>
    <name>A0A0F7N170_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleotidyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_02085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014522.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_02085"/>
    <dbReference type="EnsemblBacteria" id="AKH81158">
        <property type="protein sequence ID" value="AKH81158"/>
        <property type="gene ID" value="AA958_02085"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_02085"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.449"/>
    <dbReference type="OrthoDB" id="1607767at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002934">
        <property type="entry name" value="Polymerase_NTP_transf_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01909">
        <property type="entry name" value="NTP_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transf_2" evidence="1">
        <location>
            <begin position="12"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="257" mass="28318" checksum="194D803EBD66B508" modified="2015-07-22" version="1">MPPRDAAGPLLDRFLAALRAAVPLEALWAHGSLALGDYRPYRSDLDLIAVVRHDVGADPAARGRLEALHRRLHREVPLAAKLHCSYMALDRLAGAGLDHLTWAHAELFSRPVTPVTRRELHTGALVLHGPGPSELLPPLPDAELTAFIRKDLAEYWLPATASRRRWLRDVWVDLGPITVARAGVTLREGRLITKGEALDVLAATGAPAALVDDIRDRRYAEHPARTAPLWRLRRATLARDYVRSRIPVTLVDPGTAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N1Q9</accession>
    <name>A0A0F7N1Q9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Shikimate kinase</fullName>
            <shortName evidence="10">SK</shortName>
            <ecNumber evidence="3 10">2.7.1.71</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">aroK</name>
        <name evidence="12" type="ORF">AA958_03190</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP + shikimate = 3-phosphoshikimate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13121"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.71"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 5/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the shikimate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.71" evidence="3 10"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014707.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_03190"/>
    <dbReference type="EnsemblBacteria" id="AKH81348">
        <property type="protein sequence ID" value="AKH81348"/>
        <property type="gene ID" value="AA958_03190"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_03190"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.680"/>
    <dbReference type="OrthoDB" id="1392851at2"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00088"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004765">
        <property type="term" value="F:shikimate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
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</entry>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
    <sequence length="334" mass="35050" checksum="2B48F2BDB6E6566F" modified="2015-07-22" version="1">MEKKPQLQLGGVEIDLGRWRDFSLVPVIFVLGVIGFIVSPAFLTSDNLIGVVQQSTELGLLVLAQALILISGRMDLSLESTIGVAPVIALWLVLPAEGGRFTGIELLPSGTSIFLCLLVGAVIGLFNGFLILKLRVNGFIATLGMLVMLRGLHEGITGGKSIIEVPESFAYLGKESWLGVPAAVYVCLGLYAVGGLMLGYLRHGRALYAIGGNPEAARAAGIRVDRITWIVLAIGGMLAAFAGVLYTGHYGSVSAGQGKDMIFQVFAAAVIGGISLRGGRGTLFGALTGVLTLQLVINVMTLAGVPAEWTKFLNGAIIIVALVISRFVSGEKQD</sequence>
</entry>
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    <accession>A0A0F7N2R3</accession>
    <name>A0A0F7N2R3_9ACTN</name>
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        <submittedName>
            <fullName evidence="2">Hydrolase</fullName>
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        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S58 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016235.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_12395"/>
    <dbReference type="EnsemblBacteria" id="AKH82900">
        <property type="protein sequence ID" value="AKH82900"/>
        <property type="gene ID" value="AA958_12395"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_12395"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2605"/>
    <dbReference type="OrthoDB" id="2000083at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016117">
        <property type="entry name" value="ArgJ-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005321">
        <property type="entry name" value="Peptidase_S58_DmpA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36512">
        <property type="entry name" value="PTHR36512"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03576">
        <property type="entry name" value="Peptidase_S58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56266">
        <property type="entry name" value="SSF56266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="363" mass="35468" checksum="77CBA3B00CDE4E1B" modified="2015-07-22" version="1">MGVDGITDVAGVRVGHASRVGDGWLTGTTVVLAPEGGAVASVDVRGGGPGTRETDALDPRNIVPRVEAVVLTGGSAYGLAAASGVMAWLEEQGRGFRVGPDPAQVVPVVPAAALFDLGRGGDFRARPDAAMGREAAAAAAASASGAPVAAGNVGAGTGAVCGAMKGGVGTASTVLPSGTTVAALAVVNAAGSGVDPTTGALYAELPGAAAGGLPGPEVHAAALRRLVAAREETARRFAVSARPPLNTTLAVVATDAVLGKAQAQKLAGSAHDGLARAVRPAHLLSDGDTVFALATGARPLLSPDTATPDPAFAVHQEAGALNEVFAAGADTLTRAMAKALRTAESIDGPGGTFPSYTDLYTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N310</accession>
    <name>A0A0F7N310_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Metal ABC transporter ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_13210</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016362.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_13210"/>
    <dbReference type="EnsemblBacteria" id="AKH83030">
        <property type="protein sequence ID" value="AKH83030"/>
        <property type="gene ID" value="AA958_13210"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_13210"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2780"/>
    <dbReference type="OrthoDB" id="178322at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="136"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="285"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="316"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="665"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="697"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="729"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="763"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="790"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="824"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH83030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="852" mass="89374" checksum="EE1AF2F48D88A80B" modified="2015-07-22" version="1">MTQRVETAADGGEGPEPGGGPGGAGGKPDGAGGTARAEPGGTAGGDPGGQPGEPGGQPDRAGANGAGGTAVALRHDGLTAAEVAERVARGEVNDVPVRSSRSTADIVRANVLTRFNAIIGVLWVIMLVVAPIQDSLFGFVILANTGIGIIQELRAKKTLDNLAVIGEARPQVRRDGRTAEIPTAEIVLGDLVELGPGDKVVVDGEVLESDSLEVDESLLTGEADPVIKQPGDKVLSGSFVVAGGGAFTATKVGREAYAVQLAEEASRFTLVHSELRSGISTILKYVTYMMIPAAIGLVISQLVVENNSPQDAIRRMVGGIVPMVPEGLVLLTSVAFAIGVIRLGRKQCLVQELPAIEGLARVDVVCLDKTGTLTEGGMDVTELRPLGGAAEADVRRVLGALGSSDPRPNASLQAIIEAYPDTEELRCTGALPFSSARKYSGAAFSGDGAGAGTWLLGAPDVLLPAGDPSLAEIDDLNAEGLRVLLLARAQRELDDPEVARGVEPTALVVLEQRLRPDAADTLGYFAEERVETKIISGDNAVSVGAVAAKLGMARADRTVDARTLPADRDEMAEVLDDNAVFGRVNPQQKRDMVAALKSRGHDVAMTGDGVNDVLALKDADIGVSMGSGSEASKAVAQIVLLNNSFSTLPSVVAEGRRVIGNIERVANLFLVKTVYSVLLALLVVATQVPYPFLPRHLTLLSTLTIGVPAFFLALAPNKERARPHFVRRVMRYAIPAGLIAGTATFVTYMLARAHYSGPGALDAETSAATLTLFLIAMWVLVIIARPYTWWRVGLVGTMALGFVIVLVTPWLQKFFALKLVGAEMPWTAVGIAVASAVLLEFAWRWVTRRFPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N363</accession>
    <name>A0A0F7N363_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sugar kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_05820</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015151.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_05820"/>
    <dbReference type="EnsemblBacteria" id="AKH81798">
        <property type="protein sequence ID" value="AKH81798"/>
        <property type="gene ID" value="AA958_05820"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_05820"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1218"/>
    <dbReference type="OrthoDB" id="1604782at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="3">
        <location>
            <begin position="2"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH81798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="295" mass="28852" checksum="0F47B740CC9FD470" modified="2015-07-22" version="1">MLLVIGDVVTDVVARHSAPLAPGTDTPADIAILPGGAGANVAAWAAHCGARVRLLARAGRDAADWHRATLVRAGVDAHVRVDPEEPTGKVVALVDGGGERSFLADNGASFRLGPDDWTPGLLTGVTHVHLSGYLFFTAPGRALAALATAEAHARGATVSVDPASAGFLAESGVRDFLDAVADTDTLFPNSAEAALLSGLPSPAAAAAALATALDATAVVTAGDDGAHLATPGAPAVHIPATPVVPLDTTGAGDAFTGAYLAAAQSGGDPRAAAAAGCATAATAVRTPGGRPGQGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N366</accession>
    <name>A0A0F7N366_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SSI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AA958_13565</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protease inhibitor I16 (SSI) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016420.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_13565"/>
    <dbReference type="EnsemblBacteria" id="AKH83090">
        <property type="protein sequence ID" value="AKH83090"/>
        <property type="gene ID" value="AA958_13565"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_13565"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2855"/>
    <dbReference type="OrthoDB" id="2050426at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020054">
        <property type="entry name" value="Prot_inh_SSI_I16_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023549">
        <property type="entry name" value="Subtilisin_inhibitor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036819">
        <property type="entry name" value="Subtilisin_inhibitor-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00720">
        <property type="entry name" value="SSI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55399">
        <property type="entry name" value="SSF55399"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00999">
        <property type="entry name" value="SSI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0722">Serine protease inhibitor</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519072" description="SSI domain-containing protein" evidence="7">
        <location>
            <begin position="26"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="SSI" evidence="8">
        <location>
            <begin position="40"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH83090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="140" mass="14777" checksum="6CC9FF45E76B9C07" modified="2015-07-22" version="1">MTVRPLAAVLAATATAVLLPLTAAATASAERPLPEPFDATHLRLTTKYVSDRAKGGFTYLDCDPAGGSHPAAESACTDLAKVDGRFEDLSDKEGACTMQYEPVELHATGTWRGKPVEYVSEVFPNPCTADLATGGNVFNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3D9</accession>
    <name>A0A0F7N3D9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA thioesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_10315</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the C/M/P thioester hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015898.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_10315"/>
    <dbReference type="EnsemblBacteria" id="AKH82556">
        <property type="protein sequence ID" value="AKH82556"/>
        <property type="gene ID" value="AA958_10315"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_10315"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2174"/>
    <dbReference type="OrthoDB" id="990202at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042171">
        <property type="entry name" value="Acyl-CoA_hotdog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003703">
        <property type="entry name" value="Acyl_CoA_thio"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11066">
        <property type="entry name" value="PTHR11066"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH82556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="296" mass="32454" checksum="573F0055AE481A89" modified="2015-07-22" version="1">MDDAALTALVDLLDLEQIERDIYRGHSRAAVVPRVFGGQVAAQALVAAGRTVPADRPPHSLHAYFLRPGDPGAPLVYTVDRIRDGRSFTTRRVVAVQHGQPIFNLSASFQLHEEGLEHQVPMPPAPDPETLPTAEEAMPRYAVNFLDPALARRLLEARAAVDLRYAEPPPWGGEAGVPREPRSQVWFRTNGKLAGAIDTPLLHVCLMTYVSDMTLLDSVLLAHGRGGWAVGDVVGASLDHAMWFHRPFRADEWLLYDQESPTSQGGRGLSTGRIFTRDGRLAASVIQEGVIRVPRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3H8</accession>
    <name>A0A0F7N3H8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Endonuclease III</fullName>
            <ecNumber evidence="10">4.2.99.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">DNA-(apurinic or apyrimidinic site) lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">nth</name>
        <name evidence="13" type="ORF">AA958_14425</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="10">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the Nth/MutY family.</text>
    </comment>
    <dbReference type="EC" id="4.2.99.18" evidence="10"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016546.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_14425"/>
    <dbReference type="EnsemblBacteria" id="AKH83230">
        <property type="protein sequence ID" value="AKH83230"/>
        <property type="gene ID" value="AA958_14425"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_14425"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3036"/>
    <dbReference type="OrthoDB" id="1381897at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019104">
        <property type="term" value="F:DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00942">
        <property type="entry name" value="Nth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004036">
        <property type="entry name" value="Endonuclease-III-like_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003651">
        <property type="entry name" value="Endonuclease3_FeS-loop_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004035">
        <property type="entry name" value="Endouclease-III_FeS-bd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000445">
        <property type="entry name" value="HhH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005759">
        <property type="entry name" value="Nth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10576">
        <property type="entry name" value="EndIII_4Fe-2S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00633">
        <property type="entry name" value="HHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00525">
        <property type="entry name" value="FES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01083">
        <property type="entry name" value="nth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00764">
        <property type="entry name" value="ENDONUCLEASE_III_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01155">
        <property type="entry name" value="ENDONUCLEASE_III_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="13" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 10" id="KW-0408">Iron</keyword>
    <keyword evidence="7 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENDO3c" evidence="12">
        <location>
            <begin position="65"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="236"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="259"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AKH83230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="276" mass="30306" checksum="5F9EB302681D8002" modified="2015-07-22" version="1">MAKSGKAAPAAEGRAVVRKAKPAPTRTGLVRQARRIYRELAEVYPYAHPELDFENPYQLLIATVLSAQTTDLRVNQTTPALFAKYPTPEDLAAANPEEVEELIRPTGFFRAKTKSIMGLSQALRDDFGGEVPGNLKDLVKLPGVGRKTAFVVLGNAFGVPGITVDTHFARLVRRWKWTEQTDPEKIEQEVGSLFPKKDWTMLSHYVIFHGRRICHARKPACGACPIAPLCPAYGEGETDPEKAQKLLKYEKGGMPGQRLKPPPDYPGKPAPPLGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4E6</accession>
    <name>A0A0F7N4E6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_05410</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015081.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_05410"/>
    <dbReference type="EnsemblBacteria" id="AKH81727">
        <property type="protein sequence ID" value="AKH81727"/>
        <property type="gene ID" value="AA958_05410"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_05410"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1134"/>
    <dbReference type="OrthoDB" id="618655at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07129">
        <property type="entry name" value="ALDH_KGSADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044151">
        <property type="entry name" value="ALDH_KGSADH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="3">
        <location>
            <begin position="17"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH81727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="522" mass="53926" checksum="5067AC1020643E50" modified="2015-07-22" version="1">MCARGTETSQLSAPVWSVDPRTGNRREQVATEATAEEVDKTVRAAHAAAPALAERAQRARFLRAAADLFDRHVDKVVECADAETALGPGRLSGELTRTTYQLRAFADIAEAGDFLDVRIDHADASLAPPRPDLRRWKVPLGVVAVYSASNFPLAFSVPGGDTASALAAGCPVVVKAHPDHPGTSELSAALLHRAAEKAGLPQEVVSVVHGFDAGVELVRHPVVAAAGFTGSVRGGRALFDAAVARPRPIPFHGELGSLNPVVVSAAAAAERAEEIGAGLAGSMTLGVGQFCTKPGLVLVPAGEAGDRLVTSLTAAVSDTEPGVMLDPRMREAFIAGVRERAELPGVESPVTPGANGEHTVSGGFLTVDAERLAGGGEYELLTEECFGPVTVIVRYEDVPQVSAVLARLPGNLTATAHLGAAEAGDADAGDGGAARLFAELTPLAGRILVDGWPTGVAVAPAQHHGGPYPATTSTSTSVGGTAIERWLRPVTYQNAPQALLPAELREDNPAGVPRTVDGVREN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4H1</accession>
    <name>A0A0F7N4H1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HAD family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_08510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAD-like hydrolase superfamily. S-2-haloalkanoic acid dehalogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015617.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_08510"/>
    <dbReference type="EnsemblBacteria" id="AKH82269">
        <property type="protein sequence ID" value="AKH82269"/>
        <property type="gene ID" value="AA958_08510"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_08510"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1796"/>
    <dbReference type="OrthoDB" id="1204073at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019120">
        <property type="term" value="F:hydrolase activity, acting on acid halide bonds, in C-halide compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006328">
        <property type="entry name" value="2-HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01493">
        <property type="entry name" value="HAD-SF-IA-v2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01428">
        <property type="entry name" value="HAD_type_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="230" mass="24347" checksum="C2211295AC118906" modified="2015-07-22" version="1">MPEIRDAQVVVFDVLGTLVDEPGGLRAEIRAAAPAADDTAAGELLALWQRHVETEQARMARGERPYADSETVDREAAELVAARAGVTDPAAVARLATATRRLPPWPDSAAGLDRIARHFPVAGLSNASGPALLHLAAHGGLRWHQALSGAAVRAYKPAPEVYGLAARAADCPPERVLMVAAHAWDLRAARENGLRTAYVPRPAGDPPAATDAFDRHFDGMDGLVRALTAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4I2</accession>
    <name>A0A0F7N4I2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Primase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_12375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH82896">
        <property type="protein sequence ID" value="AKH82896"/>
        <property type="gene ID" value="AA958_12375"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_12375"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="68" mass="7964" checksum="20DCAD40DEC56968" modified="2015-07-22" version="1">MDDLEDDEEEEDEDVEEDDEPEDEEEEDEDDEEDEADDSELFFSPDPDPDPEPDPPEPEPEPLRLSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4N3</accession>
    <name>A0A0F7N4N3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LuxR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_05900</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015165.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH81812">
        <property type="protein sequence ID" value="AKH81812"/>
        <property type="gene ID" value="AA958_05900"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_05900"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1235"/>
    <dbReference type="OrthoDB" id="1687028at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="3"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="148"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH81812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="222" mass="23997" checksum="E48BF79F58836AD6" modified="2015-07-22" version="1">MIRILLADDQKLVRAGFRSILADEDDLDVVGEASDGAEAVAACRELRPDVVLMDIRMPGTDGLEAARRIAADERLADVRVVILTTFDLDDYVYGALRAGAAGFLVKDTEPEELIHAVRVAARGDALISPSVTRRLIAEFAGRVEAPEPSPRLNALTEREAEVMQLVAAGLTNDEIAARLVLSPATAKTHVSRIMTKLGVRDRAQMVVLAYESGMVRPGWLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4Z2</accession>
    <name>A0A0F7N4Z2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_13515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016411.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_13515"/>
    <dbReference type="EnsemblBacteria" id="AKH83081">
        <property type="protein sequence ID" value="AKH83081"/>
        <property type="gene ID" value="AA958_13515"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_13515"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2844"/>
    <dbReference type="OrthoDB" id="1244860at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="283" mass="30472" checksum="E6204680FE7884E6" modified="2015-07-22" version="1">MVSPERSWRAAPPGRGARPVGSVTRGTTHPNRLRRMDRWIAAAHGAALRRTARAEGRAVAVDLGYGATPWTAVELLARLRAACPRAEVAGVEIDPERVAAARPYAREGLTFLRGGFEVPLPGGARPALIRAANVLRQYGEEEVPAAWARLTARLGADGLLVEGTCDEAGRRHVWVALGPEGPRTVTFAAHLATLPSPSDLAERLPKALIHRNVPGEPVHAFLRDVDRAWSAAAPYAPLGARQRWIRTASALSADWPLTDGPGRWRQGELTVPWAAVAPRGWTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N598</accession>
    <name>A0A0F7N598_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF45 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_14135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_14135"/>
    <dbReference type="EnsemblBacteria" id="AKH83181">
        <property type="protein sequence ID" value="AKH83181"/>
        <property type="gene ID" value="AA958_14135"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_14135"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2975"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002725">
        <property type="entry name" value="YgjP-like_metallopeptidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01863">
        <property type="entry name" value="DUF45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF45" evidence="1">
        <location>
            <begin position="35"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="260" mass="29229" checksum="85595AFB17391C86" modified="2015-07-22" version="1">MIPDADDRTPPGLADGARITVDGVLLSVRVSARRKRFALTVEADAGVTLHVPEGRPAAEAEDFVRDHRRWMLGKIDARERVLPVNPAKRLIEGEVFRYLGRLYRLAITDDGPPDGRVRLVAGRLVMSHQQAVDPDLGRAGLVEWYCRAGLAWSLGRLQPWAARMAVREPALRVHDLGRRWGTYQPGEGDRGPGRMTLGWPLFQLPMHLVDYVVAHELAHVRIPGHGADYWRLLASALPEYQERRAELDELGRRIWVGEIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5C1</accession>
    <name>A0A0F7N5C1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Membrane protein insertase YidC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Foldase YidC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Membrane integrase YidC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Membrane protein YidC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">AA958_10690</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015954.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_10690"/>
    <dbReference type="EnsemblBacteria" id="AKH82613">
        <property type="protein sequence ID" value="AKH82613"/>
        <property type="gene ID" value="AA958_10690"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_10690"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2249"/>
    <dbReference type="OrthoDB" id="524437at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032977">
        <property type="term" value="F:membrane insertase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028055">
        <property type="entry name" value="Membr_insert_YidC/Oxa1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001708">
        <property type="entry name" value="YidC/ALB3/OXA1/COX18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428">
        <property type="entry name" value="PTHR12428"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02096">
        <property type="entry name" value="60KD_IMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03592">
        <property type="entry name" value="yidC_oxa1_cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="25"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="226"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="185"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00033342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AKH82613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="277" mass="28899" checksum="A2A8ABF7B10A9343" modified="2015-07-22" version="1">MSVFGALSALLSGLAGTLDPFFGASATGVAIIVFTLCVRLALHPLARAAARGDRVRRDLAPQVAEIRRKHRHDPERLRRALTETYAEAGASPLAGCGPMVLQIPVFMVMYRLFTGHDHDLLTHTLLGAPLGGRWSDALADGGVFGAHGMVYAGLFAVIAGVAAYTFWRSRRMMAERKAGAEAIRKAATSKGAGSGKNGKGGKKGGKAQAAAPPPGLPGPAAGLTRWLPLLSFGTLVTAAIVPLAAGLYLATTAAWTAAERTLLYRRPGPRAEQGIAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5L7</accession>
    <name>A0A0F7N5L7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptidase_S8 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_18530</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017167.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_18530"/>
    <dbReference type="EnsemblBacteria" id="AKH83870">
        <property type="protein sequence ID" value="AKH83870"/>
        <property type="gene ID" value="AA958_18530"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_18530"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3889"/>
    <dbReference type="OrthoDB" id="923655at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017297">
        <property type="entry name" value="Peptidase_S8A_DPH-A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037854">
        <property type="entry name" value="Dihydropyridine_esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519810" description="Peptidase_S8 domain-containing protein" evidence="6">
        <location>
            <begin position="31"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S8" evidence="7">
        <location>
            <begin position="242"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH83870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="1121" mass="115645" checksum="F7EFD9131866D469" modified="2015-07-22" version="1">MRRHIKRARAAALAAAAATALTAGLTAAPAASASPAAGSAGAAGSSGGNGQAQYAKQGGTWVTLITGDRVRVDADGKAVVIDRGPGRAGIPVRTFERDGHTYVVPRDATALVADGTLDRRLFDVTLQARPEYVRQQRAGLKLIVDYRGESPAAQNRLHAADGTDVEHRFPRLNAEAVTTAKGEAAGAWKALTRAQRGGSAAEPLAAESGVKRVWLDGVRRASLDVSVPQIGAPAAWEAGYKGDGVKIAVLDTGVDETHPDLAGQVVASENFTPAADAEDRYGHGTHVASIAAGTGAKSGGKFTGVAPEAKLLAGKVLDDDGYGDDSGILAGFEWAVAQDADIVNLSLGGGDTPEVDPLEEAVNRISADEGVLFAVAAGNEGSGSHTISSPGSADAALTVGAVGANGGLAGFSSRGPRIGDSAVKPDVTAPGVAITAAAAPGSVIDQEVGQNPEGYLTIDGTSMATPHVAGAAALLAEQHPDWTGQQLKAALSASAKPAAKRGAFGQGAGLIAADQAVGQSVVSEPTSLSFGRQEWPHQDDQPVTKTITYRNLGTEDVTLSLTASTVQPGGAAAPSGMFSMGTDVITVPAGGTAELPVTVDTRRGGDVDGAYSVYVTATGDGQRVVTPGGVEREGEAYDVTLKFLGRDGQPTTDGTALLTGMEESNWEIWEERAGQSTATVRVPKGRYLLNGDVAKFDGDTLTEYDWINQPRLDVTGDTTVTLDARTAKPVDLTVPDGAAVRTNLDVTVDVSADAGGMGLGTSVEGDVDARTAHLGPALAAGELYQQVQANFASGARTEYQTVYSDANRTTAWTGITRATPQSELAKLDLTLGSSAEGRQGLVWAVPYIGGSTGATATARELPYKGTLYVRGGDRINWQLEYWQLGEEWEDIAYSTEARTYAGGSTYKESFNAAVVGPILTKDTGVYRDGNTIDALLPVYLDNPAHYGYSQYENADTTLYRNGTKLGSVADIPIGVGFTVPAGSADYKLTTSSTRPATVARTSTKVTATWTFSSASTDSPKKLPFSVVRYSPTLSAASSSNAGATKSVPVKVLGSAAGSNLKSLTVWASTDGGATWKELPVRDGKVSVVNPAAGKSVSFKAKAVDKQGNSVQQRIFDAYRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N629</accession>
    <name>A0A0F7N629_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_08570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015625.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_08570"/>
    <dbReference type="EnsemblBacteria" id="AKH82277">
        <property type="protein sequence ID" value="AKH82277"/>
        <property type="gene ID" value="AA958_08570"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_08570"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1808"/>
    <dbReference type="OrthoDB" id="1622507at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH82277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="327" mass="35236" checksum="03EB5BB1CDBB1896" modified="2015-07-22" version="1">MPTHRISAPLPAFDPAQAEVVMLPEAPEAGYWTGCPGVLYEPEQGRWLMTYRRRRPRGHPGGERGWRCAVAVSEDGVDFTDMWSVESRQLGTDSMERFSLLPTPGGYQLYLSYVDPADSRWRIDVVDAAAPDAFDLAGARPALTAAGTGTEGVKDPYTLRHGPVTYLFASYAAAGIAAADADRAHATADVFNTGVTTHPTGLALSLDGGATFAWQGEAMPTGSGWDAYQTRLNSAVPLGPGAGWLGFYDGIASHEQNYEENCGLAVSYDLRTWHRLSTEGPWAAVPYGTGSVRYVDAVVAEGTWHLYFEAARPDGAHELRLARVPVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N699</accession>
    <name>A0A0F7N699_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cupin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_20315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017429.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_20315"/>
    <dbReference type="EnsemblBacteria" id="AKH84140">
        <property type="protein sequence ID" value="AKH84140"/>
        <property type="gene ID" value="AA958_20315"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_20315"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4278"/>
    <dbReference type="OrthoDB" id="1928636at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="1">
        <location>
            <begin position="33"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="134" mass="14604" checksum="8B8ACBEFA3A7A764" modified="2015-07-22" version="1">MSTHPAEPTALSDALERIAEPWSPHVVARVNDYDVKLAHAEGEHLWHVHEHTDEFFLVVEGELRIGLREPDGGERTVTLPRGAVFTVPRGVEHRPVAAPGTAIMMFEPAGTVNVGDRHEAVPAHIPATTGFELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6E3</accession>
    <name>A0A0F7N6E3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">NADH-quinone oxidoreductase subunit F</fullName>
            <ecNumber evidence="12">7.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">AA958_20605</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 12">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the complex I 51 kDa subunit family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="12"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017476.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_20605"/>
    <dbReference type="EnsemblBacteria" id="AKH84190">
        <property type="protein sequence ID" value="AKH84190"/>
        <property type="gene ID" value="AA958_20605"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_20605"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4347"/>
    <dbReference type="OrthoDB" id="688908at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001949">
        <property type="entry name" value="NADH-UbQ_OxRdtase_51kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011537">
        <property type="entry name" value="NADH-UbQ_OxRdtase_suF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011538">
        <property type="entry name" value="Nuo51_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037225">
        <property type="entry name" value="Nuo51_FMN-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019575">
        <property type="entry name" value="Nuop51_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037207">
        <property type="entry name" value="Nuop51_4Fe4S-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019554">
        <property type="entry name" value="Soluble_ligand-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01512">
        <property type="entry name" value="Complex1_51K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10589">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10531">
        <property type="entry name" value="SLBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00928">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140490">
        <property type="entry name" value="SSF140490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142019">
        <property type="entry name" value="SSF142019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01959">
        <property type="entry name" value="nuoF_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00644">
        <property type="entry name" value="COMPLEX1_51K_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00645">
        <property type="entry name" value="COMPLEX1_51K_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5 12" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 12" id="KW-0288">FMN</keyword>
    <keyword evidence="9 12" id="KW-0408">Iron</keyword>
    <keyword evidence="10 12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 12" id="KW-0520">NAD</keyword>
    <keyword evidence="14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-0874">Quinone</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <feature type="domain" description="NADH_4Fe-4S" evidence="13">
        <location>
            <begin position="333"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU364066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AKH84190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="448" mass="48653" checksum="94B2558057A03671" modified="2015-07-22" version="1">MTVDSPEKLLTPVLSAFWDDPESWTLDTYRRHEGYQGLRKALAMSPDDVIAYVKDAGLRGRGGAGFPTGMKWQFIPQGDGKPHYLVVNADESEPGTCKDIPLLFANPHSLIEGIVIACYAFRSNHAFIYLRGEVVPVLRRLHEAVREAYAAGFLGKNVLGSGLDLDVTVHAGAGAYICGEETALLDSLEGRRGQPRLRPPFPAVEGLYACPTVVNNVESIASVPAIMNKGKEWFRTMGSEKSPGFTLYSLSGHVARPGQYEAPLGITLRQLLDMGGGMRPGHRLKFWTPGGSSTPMLTDEHLDVPLDYEGVGGAGSMLGTKALQCFDETTCVVRAVTRWTEFYEHESCGKCTPCREGTYWLVQLLRDIEAGKGALADLDKLNDIADNINGKSFCALGDGAAAPIFSSLKYFRDEYEQHITGGGCPFDPARSTAWADTPGSTTHQEVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6G1</accession>
    <name>A0A0F7N6G1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_17245</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016970.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_17245"/>
    <dbReference type="EnsemblBacteria" id="AKH83666">
        <property type="protein sequence ID" value="AKH83666"/>
        <property type="gene ID" value="AA958_17245"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_17245"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3626"/>
    <dbReference type="OrthoDB" id="1437290at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041347">
        <property type="entry name" value="MftR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17754">
        <property type="entry name" value="TetR_C_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="13"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH83666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="217" mass="22828" checksum="65DCDF4F1E91F109" modified="2015-07-22" version="1">MTTPPGLRERKKQATREALREAALRLAVEHGPDQVRAEDIAEAAGVSPRTYHNYFASREQAIASAVTADRETRIAAAVAARPADMRLADAVTEAVVQQYTNTGEREHKALLLITTQTALRDAFLDTTAGIEPPLTAVIAERLGDSEAPTARVLAASVTAAVRIALEGWLRPAGNTEVAGSSGAGGLLVPSGSLPDRLRAALAPLAPAFDAAEQHTRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6H4</accession>
    <name>A0A0F7N6H4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_20915</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017530.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH84245">
        <property type="protein sequence ID" value="AKH84245"/>
        <property type="gene ID" value="AA958_20915"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_20915"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4407"/>
    <dbReference type="OrthoDB" id="2013794at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046030">
        <property type="entry name" value="DUF5988"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19450">
        <property type="entry name" value="DUF5988"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH84245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="69" mass="7888" checksum="A8C1658A11B8A5BD" modified="2015-07-22" version="1">MPHSKIVILADCPFAIPLLPAAARVDHESEVKIMQGNGYEHFEFIGEYIEVSGILTPVYRWRNRTFIAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7C1</accession>
    <name>A0A0F7N7C1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">LytR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_11435</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LytR/CpsA/Psr (LCP) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016078.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH82742">
        <property type="protein sequence ID" value="AKH82742"/>
        <property type="gene ID" value="AA958_11435"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_11435"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2406"/>
    <dbReference type="OrthoDB" id="491753at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027381">
        <property type="entry name" value="LytR/CpsA/Psr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004474">
        <property type="entry name" value="LytR_CpsA_psr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13399">
        <property type="entry name" value="LytR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03816">
        <property type="entry name" value="LytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00350">
        <property type="entry name" value="lytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="159"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="LytR_cpsA_psr" evidence="4">
        <location>
            <begin position="233"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="LytR_C" evidence="5">
        <location>
            <begin position="500"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="588"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH82742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="620" mass="65400" checksum="2B2C1D3931F9FF02" modified="2015-07-22" version="1">MFNPETGSYELRLDPQIPGRQAPQPHGHHAPGPHGHAPHGYGGPPQQPQQYIPQQSGQPSHGQAAPGPQHAQPPHAQPHPGPPQPGQPHTGGPPRPGDRHQSHASPAEAPESLQEPRLPSQRRRGAAGGSGGAGGSGPDGDGPRSRRRPKPRKSKKKKALIWVAGGLAVVLFAVGTAAFLIYRKLNGNIDKVEVAGEDHAAVIDGPVNILVMGTDKRTGKGNDGYGDMNSPGHADTTLLFHVSEDRTNATAMSIPRDMITDIPDCKTKQEDGSWKTIPGTYETKFNESLGQFGRDPGCTWKTVEQLTGLDVNHFILADFNAVKDLSSAVGGVEVCLAEDINDPKSKLNLPAGRHTVEGEEALAFVRTRYSVGFGSDLSRIELQQQFLSSLIRKMKSGGSLSNPKKMYDLADAATKALTVDSGIGSAKKLMDLANDLKKVPQDDITFATLPVLDNPEDDATVLMDEAKAKPLFKLLAADKPFDGAKKGKKDKPVKKSEPGEVRVDVVNGGGESGMASATAGWLLDEGAGYAAEAGNTPDLQPETRLEYGPDQAEQAARLADMMGLPKSAMKKTGENAGAGGTMTLTLGEDFAAPGTPVEAPDKAPDGVQNVKAGDKNVCAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7C7</accession>
    <name>A0A0F7N7C7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Metal ABC transporter ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AA958_14935</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016613.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_14935"/>
    <dbReference type="EnsemblBacteria" id="AKH83298">
        <property type="protein sequence ID" value="AKH83298"/>
        <property type="gene ID" value="AA958_14935"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_14935"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3147"/>
    <dbReference type="OrthoDB" id="237367at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="36"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="94"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="290"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="624"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="428"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH83298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="685" mass="69123" checksum="D60FC82BD3D93323" modified="2015-07-22" version="1">MPHTLTQPDPQTARAAATPAPAAAPRRPGPLSVPEARWAAAALALFLLALPLDLLGAPAWSWGPLYALTYAAGGWEPGWAGLRALKDKTLDVDLLMVVAALGAAALGQFLDGGLLIVIFAASGALEAIATARTADSVRGLLDLAPATAVRVAADGTEEDVPTGQLRVGDVILVRPGSRIGADGRVLDGASEADQATITGEPLPVPKEPGDEVFAGTLNGTGALTVRVGRDPADSVIARIVAMVEEASRTKAPTQLFVEKIEQRYSIGMVAATVALFAVPLLLGAELESTLLRAMTFMIVASPCAVVLATMPPLLSAIANAGRHGVLVKSAVVMEQVGQADRAALDKTGTLTEGRPHLTDVRPLDGSGMTEDDLLALAAAAEYPAEHPLARAVVAAARGRALPVPAVRDFTAAPGRGVTATIAGARVTVGSPAGLRGEDPDPDSGPDSGPAPGASPGTPPDAAAAARQVVGELEGEGRTAVVVARDGTPVGVLGIADRTRPDAPGTVAALAALTGAPPLLLTGDNAPAAHRLAAGVGIAAADVHAGLLPQDKAETVRALQSGGGRVLLVGDGVNDAPALAAAHTGVAMGRAGSDLALETADAVVVRDELTAVPAVVALSRRARRLVVQNLVIAGVCIAGLVVWDLAWHLPLPLGVAGHEGSTVLVGLNGLRLLRTAAWRRAAAEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7P9</accession>
    <name>A0A0F7N7P9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetylmuramic acid 6-phosphate etherase</fullName>
            <shortName evidence="3">MurNAc-6-P etherase</shortName>
            <ecNumber evidence="3">4.2.1.126</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">N-acetylmuramic acid 6-phosphate hydrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">N-acetylmuramic acid 6-phosphate lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">murQ</name>
        <name evidence="5" type="ORF">AA958_19800</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D-lactate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>H2O + N-acetyl-D-muramate 6-phosphate = (R)-lactate + N-acetyl-D-glucosamine 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:26410"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:57513"/>
            <dbReference type="ChEBI" id="CHEBI:58722"/>
            <dbReference type="EC" id="4.2.1.126"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-sugar metabolism; N-acetylmuramate degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="3">A lyase-type mechanism (elimination/hydration) is suggested for the cleavage of the lactyl ether bond of MurNAc 6-phosphate, with the formation of an alpha,beta-unsaturated aldehyde intermediate with (E)-stereochemistry, followed by the syn addition of water to give product.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GCKR-like family. MurNAc-6-P etherase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.126" evidence="3"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017342.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_19800"/>
    <dbReference type="EnsemblBacteria" id="AKH84051">
        <property type="protein sequence ID" value="AKH84051"/>
        <property type="gene ID" value="AA958_19800"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_19800"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4172"/>
    <dbReference type="OrthoDB" id="1100044at2"/>
    <dbReference type="UniPathway" id="UPA00342"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016835">
        <property type="term" value="F:carbon-oxygen lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046348">
        <property type="term" value="P:amino sugar catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097173">
        <property type="term" value="P:N-acetylmuramic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05007">
        <property type="entry name" value="SIS_Etherase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00068">
        <property type="entry name" value="MurQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005488">
        <property type="entry name" value="Etherase_MurQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005486">
        <property type="entry name" value="Glucokinase_regulatory_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040190">
        <property type="entry name" value="MURQ/GCKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10088">
        <property type="entry name" value="PTHR10088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10088:SF5">
        <property type="entry name" value="PTHR10088:SF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13580">
        <property type="entry name" value="SIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00274">
        <property type="entry name" value="TIGR00274"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01272">
        <property type="entry name" value="GCKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SIS" evidence="4">
        <location>
            <begin position="64"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH84051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="311" mass="31864" checksum="5EBEF7682457DFA0" modified="2015-07-22" version="1">MPSPSADIRRELENLTTEAFRPELAEIDRLSSLEIAGIMNEEDSGVPGAVATQLPRIAAAIDEIAERMARGGRLFYLGAGTAGRLGVLDASECPPTFNTDPSQVVGMIAGGDVALRTSTEGAEDSEELAAADLAAAELGPDDAVVGISASGRTPYAVGGVTYARGLGALTVGLSCNAGSPLGAAAQHAIEVVVGPELIAGSTRLKAGTAQKLVLNMLSTITMIRLGKTYGNLMVDVRASNEKLRARSRRIVALATGAGDEEVEAALAETHGEVKNAILTILGGVDGSTAERLLDASHGHLRVALKSATDVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7R5</accession>
    <name>A0A0F7N7R5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Enoyl-CoA hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_23275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017896.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_23275"/>
    <dbReference type="EnsemblBacteria" id="AKH84640">
        <property type="protein sequence ID" value="AKH84640"/>
        <property type="gene ID" value="AA958_23275"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_23275"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4906"/>
    <dbReference type="OrthoDB" id="1275789at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="267" mass="27426" checksum="266DAE95265049E0" modified="2015-07-22" version="1">MADTVLYEVADGLATVTLNRPDAMNALDTETKNALRDTLREAAADEAVRAVLLTGAGRAFCVGQDLKEHIGTLAAARAAQRTDHAMDTVTEHYNPIAATLAGMPKPVVAGVNGVAAGAGAGFAFAADYRVVADTASFHTSFAGVALTADSGVSWTLPRLVGHGRAADLLLFPRRIPAAEALALGIANVVVPAAELAAEAAAVARRLAAGPTGAYAAIKESLAYGAGHGFAETLAREAELQSRAGASEDHRIAVEAFVAKEEPRFTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7T7</accession>
    <name>A0A0F7N7T7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">CNQ-509</strain>
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    </dbReference>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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        </source>
    </evidence>
    <sequence length="87" mass="9998" checksum="C19E1E0D0D5024CA" modified="2015-07-22" version="1">MSEPEPVIESYAFACMMCGHGWEQSYEIHHHVDSKGRPFVTYHTDGERVPSPLTRPTCLNCGEHVVRIMRAGQVRSVESVRQRSRRT</sequence>
</entry>
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            <authorList>
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                <person name="Albersmeier A."/>
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                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <evidence type="ECO:0000256" key="1">
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="AKH84156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="98" mass="10452" checksum="63FE13751056975F" modified="2015-07-22" version="1">MTTETGNGRVAPAPAGRPRSLPAPGFAEVRIVAADPEAARRIAEVLRLRFAADEQRSYPAGEDGQGTRLHLTIDTVHAPEPIEPSRLLGTGHPHADEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
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        <name evidence="3" type="ORF">AA958_22310</name>
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    <organism evidence="3 4">
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                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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    </dbReference>
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            <end position="526"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="554" mass="58102" checksum="0BB6B6E6B220A626" modified="2015-07-22" version="1">MADDGGGAGVWSHASAQLGELLDLVDEAIVTCDRPDGTIRGFNRAAVRLFPRLRPGEPASASAPPLARAGARGAKRFSAAHGGRRLRGRLRTVDGLAVWLVSQVSSAQEAEAALVDERARSAFLEEATQRLGASLHHSRTVRTLTEIVTPRLADASVVVLPPSGRRTDWHRAGPGGARSSGEVAVERLEEVPEIANALYGLQPHPTVISPQELDPLDNLMPAELVPGGEPLVAQLAAGGVPAGALIMLRGPERAPFDEADIELAHELAVRAGLALATAALYTQQAHTIAVLQASMAPEPLPAADGLRLGAAYRPAAEALHISGDFYHVAPSALGGVTFFFGDVSGKGAEAAVLAGHLRQSMRTLAMVAQESEPLRDLYLLNEIVLSDGHRFATLVTGSARPRDDGSVKVEIAGGGHLSPLVLRGDGRVEEITCEGTLVGAVPDPGFSLTEVVLEPGELILFYSDGVTEARGGASGREMYGDERLVDALASCTDMQAASVAERLELLTTEWLAGRPHDDISILTLQAPPRRGASLQRQPGSHASPPLPGRPGSHE</sequence>
</entry>
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                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
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                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
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        </location>
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    </evidence>
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    </evidence>
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</entry>
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    <organism evidence="3 4">
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        <lineage>
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    <reference evidence="3 4" key="1">
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
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        <property type="entry name" value="Aldolase_TIM"/>
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        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519373" description="Glyco_hydro_114 domain-containing protein" evidence="1">
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            <begin position="22"/>
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        </location>
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        <location>
            <begin position="51"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH83884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="275" mass="29293" checksum="C007463D50797F07" modified="2015-07-22" version="1">MTRVRTRRAGAALAGAAVVAAALLVALVVVPRDDGDGAREPVLPPPGAGVDYQIGGAYDPPPGVEVVVRDRGDAPAPGAYNVCYVNAFQAQPGAEDRWDTDLLLRDAAGEVVYDEDWGEAVLDLRTAGKRERIAAKVGRWIDGCAERGYQAVEPDNLDTYTRFPRLLTAGDARAYAALLADRAHARGLAVAQKNTAELAPDRARTGLDFAVAEECGEYDECAAYSAAFDDRVLVVEYTPDGLAAACGRWADRLSIVRRDRAVSPEGAAGYVRETC</sequence>
</entry>
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
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    </dbReference>
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    </dbReference>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AKH85030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="506" mass="51296" checksum="9ED01614D400C4F3" modified="2015-07-22" version="1">MDTTKTEATGSRRWLALAFIGLAQLMIVLDVTIVNIALPSAQADLGISDGDRQWVITAYTLAFGGLLLLGGRIADYTGRRRAFLTGLVGFAAASALGGAAPGFGALLGARAAQGAFAALLAPAALSLLTTSFTEQRDRARAFGIFGAIAAGGGAIGLVAGGALTEYLDWRWCLYVNVPIAVLAAAGWWVLPADTRPQVRQRIDGPGAVLAVTGLVAVVYGCSEAESEGWDSALVLGLLFLGVALLTGFVLYERNAAAPLLPLRVVLSRARGSAFLGIALATVGMFAMFLFLTYYMQVVMGYSALKTGVAFLPLTAGVLAGAGGLASRLLPRVPPRALIVPGLLLASAGTGWLATVDVDTSYAAGVLPAELVLGFGMGMVMAPAINYATHGVRAEEAGVASATVNTAQQIGGSIGTALLNTIATSTTADYLAERLPAAGALEERRAAGGPVPDVVKAGLVEGFSSAYTVASAILVVAAAVVAVVMNTPRPAPAKPGAPAPAPAAHLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N981</accession>
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        </submittedName>
    </protein>
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    </gene>
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        <lineage>
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        </lineage>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
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        <property type="gene ID" value="AA958_14920"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_14920"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3144"/>
    <dbReference type="OrthoDB" id="1714516at2"/>
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    </dbReference>
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        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH83297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="208" mass="21715" checksum="3DE48D71B1913FAF" modified="2015-07-22" version="1">MIRTRSLSRRGAAAATAGAVALLLAACGGNDDESGDHGKHGGASASSPADSQKEQNAADVTFAKGMIPHHRQAVEMAGLAPERAASDEVKKLAAEIKKAQDPEIETLSGWLTSWGEDVPAEGEMDHSMHGSAGGMMTAEDMKSLEKAEGAAFDTAFMEMMIEHHEGAVAMAETEQADGSYPPAKEMAGQIISSQEAEIDAMKSMLDQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N998</accession>
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        </submittedName>
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        <lineage>
            <taxon>Bacteria</taxon>
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    <reference evidence="2 3" key="1">
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
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        <location>
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            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="397" mass="42642" checksum="54FCAFA3E99DAF24" modified="2015-07-22" version="1">MKESPARFADLAGLRLYRRNIFAVTGLPVAAQGPAVRRHRQRLDARLAVEETWAGDAAAPAPGGYRREEVRHAFEEFQDPRRRLVDELLWFWRDADLGCGCAPSTHRRHDEAVRLHSRAIEAETGGAGPRGDGPDGLWTAAATAWASVLDNPDLRGHVAHRITALADPRLDGYSPDDFLAGVPGLLLSPFGELADDRSARPRLAKVSAGWSAYPVFATPLPDVFENTVEQSVDRLKDALRTAGERHQAGEHADALAALEQRVLPAYDEFESLKGFVSQSRSEEMAHTVTVALNNVALGVCEAGLQKPFRSELIEVMEHASRIAPRRDKAQIDQNLAAVRQGRAGAGAAQQLKPSECAGCVVLLLAIIGGIVGGITAGAPWAVGIIVGGFVLAGMFAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9C1</accession>
    <name>A0A0F7N9C1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_23205</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017883.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_23205"/>
    <dbReference type="EnsemblBacteria" id="AKH84626">
        <property type="protein sequence ID" value="AKH84626"/>
        <property type="gene ID" value="AA958_23205"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_23205"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4892"/>
    <dbReference type="OrthoDB" id="1479518at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="145"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="246"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="292"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="106"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH84626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="325" mass="35752" checksum="4623F6B8CCA7C501" modified="2015-07-22" version="1">MLRFLIRRTIGALIILLILSAVCFFLFFAIPRDPARISCGEKCTPENLELIRRALGLDDPVPVQYWNFLSGIFAGRSFPTGECPAPCLGRSFVHDENVLTLIQDRFPTTLSLTIGAAVVFLFFGVGAGMIAAWRRGTVLDKFVSGSSLIIGSLQIYFIGPLVLWALVYSTGLFGDPAYNAFTDNPWKWAVGLILPWAVLSTIFASNYTRMVRSTMIEQLQEEHVRTARAKGMSSGTVFFRYAWRGALIPVVTIFGIDLGSLLGGAIITEFTFSLPGLGQLSIDSVFKADLPVLMGILLFSSTMIILMNVIVDAAYAFIDPRIRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9E1</accession>
    <name>A0A0F7N9E1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Suppressor of fused domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_23330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017907.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_23330"/>
    <dbReference type="EnsemblBacteria" id="AKH84651">
        <property type="protein sequence ID" value="AKH84651"/>
        <property type="gene ID" value="AA958_23330"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_23330"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4918"/>
    <dbReference type="OrthoDB" id="1764812at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020941">
        <property type="entry name" value="SUFU-like_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05076">
        <property type="entry name" value="SUFU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SUFU" evidence="1">
        <location>
            <begin position="31"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="202" mass="21240" checksum="BE9A33A1976DD009" modified="2015-07-22" version="1">MAYDDVLAQVERRLTGAFGEPDARASVTFVGTDRIEVARFTSATAGGEPLLRYATLGMSAQPMTDPAQALADPLRGPRAELLLTVRAGLADTDKVLRPLAVLAASPQVEGVVVAPGASLEVGGPLWPGAPFRAVLVAEPGGLVDDVVLPEPREPVRFLPLLPMTPNEAAWKRVHGAAALSERWLAAGTDLRDPLRRGVELGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9I0</accession>
    <name>A0A0F7N9I0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Replication initiation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_15350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_15350"/>
    <dbReference type="EnsemblBacteria" id="AKH83357">
        <property type="protein sequence ID" value="AKH83357"/>
        <property type="gene ID" value="AA958_15350"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_15350"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3229"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH83357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="382" mass="41918" checksum="BB1F42EBC286EB71" modified="2015-07-22" version="1">MPAGDLLVRCGNRRTTRCPACAETYRRDTFHLITAGLRGGKGTPEGVTSHPRVFATFTAPSFGPVHNRPGTRACRCGRHHTPDDSTLGTPLNPDRYDYETAVLWNAHAGALWRRFTIHLRREIARRAGLTQRAFPQHARVSFAKVAEYQKRGAVHFHAVVRLDGPAGGNTPPPHWATAELLTDAIQAAASRAVVPGPILDGRAHTFAFGPQLDIRTIHGQDLDGDQALTDRAVAAYIAKYATKGAETATGPLDRRLRFIAELGHLDLPPHAERLIRTAWALGARRDLAHLRLRAWAHMLGFRGHFSTKTRRYSTTLGALRTARAEWRRLQAAIARGDNPQPVDGPDDVTTLVLAHWTYTGTGLTPAEAWLSASLALEGDNSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9K8</accession>
    <name>A0A0F7N9K8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_20230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017413.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH84124">
        <property type="protein sequence ID" value="AKH84124"/>
        <property type="gene ID" value="AA958_20230"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_20230"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4260"/>
    <dbReference type="OrthoDB" id="1509257at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH84124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="311" mass="31941" checksum="8D97A1491B865279" modified="2015-07-22" version="1">MSCPELPRTASGEVLVICTYYDKGEPCWGGLGDRTGDGAATVPDGGGPVRLRRVADAGWDGLRGGNVPALLPGGGSDAPVAVLVDCAAVYGGEPLLVDVAAIPGRGARIAADRLGEILGALLDGTLVFDDLVRVMDGQGTYQGDAGRPAFPAPTTPPPRSFPALPATDGALLVRTSFEDDEGWRALLAELGGTDEEGWVGADIDPDDIDVDEYPLTALVVDDPAYAGLPPGAVPALVPPGGHAVVVALADAGTFAGADRPLVAVDLDDVPGHIAVLPWREAGSMVCNLEIANMDFSDYVAVEGVKPWWEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NA61</accession>
    <name>A0A0F7NA61_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_27965</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018669.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_27965"/>
    <dbReference type="EnsemblBacteria" id="AKH85435">
        <property type="protein sequence ID" value="AKH85435"/>
        <property type="gene ID" value="AA958_27965"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_27965"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5894"/>
    <dbReference type="OrthoDB" id="1179151at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="13"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="257"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="45"/>
            <end position="52"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH85435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="281" mass="29479" checksum="0B6FC1C0F81DA8C8" modified="2015-07-22" version="1">MTAPAAPAAPTVLSLRGVSKQFGAVAALTGIDLDVAAGEVVAVVGDNGAGKSTLVKILSGVYTPDGGTITFHDREVSLGSPADAQAIGIATVFQDLALCENLDVKANLFLGQELRPWMLDDVRMETRSWELLRELSARIPTLDVPVAALSGGQRQTVAITRALLGKPEVILLDEPTAALGVAQTAEVLNLIERLKGNGLGVVMISHNMDDVRAVADRVAVLRLGRNNGVFDARTVTSEQVVAAITGAVDNVVAQRAARRAAAGEPRPDAATRNERKEKELP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NA90</accession>
    <name>A0A0F7NA90_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_21575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017621.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_21575"/>
    <dbReference type="EnsemblBacteria" id="AKH84359">
        <property type="protein sequence ID" value="AKH84359"/>
        <property type="gene ID" value="AA958_21575"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_21575"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4543"/>
    <dbReference type="OrthoDB" id="1601950at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="476"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="547"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="639"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="720"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="722"/>
            <end position="743"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="743" mass="76109" checksum="7C47F675143D0B71" modified="2015-07-22" version="1">MHFLRPLVTFPRVVRHYSWVGADLPLDEDVLLDAPGQRVRAVLPAAEAGDFRPARELLAGAGRAAEWERRDTYVAELATAALDDDGWLRRWREWDPECGDAAVVEAERLLRAWRAERYGPRRRRFEGWGVRRRGGAAPGPWAGAGPAEGAGAGGGDGDGAGGAWAGMADAESWPWYGVPGAGPGYGRPGSGTEHDRPGTGAGAGADSGAGPGGPAPGGGDPRTGAGGTAGTAGAAGAAGPGGGRRSRGPYGAGGLPATDPRAVLRDVLPLVRLAAAHAPGDPVPWRIALDHATAVRAPREAFVSRFAEAVVRAPGHHGAHVAALRYLAIVGDADVEELMVFAEESAEEALPGSLLHALPLEAASLGVCRTRSTPSGGPDPADAPGSSTTWAVERALELSAHYEPGDAEAAGFRNCLAAALVRARRWDEALEVFRAVGSDARGVPWARPGDDTEAIRRRFLLARQEVRAQLARRVPLFGPRPDNAPGPGAAFGPAGPGTRPEPAPYAGIVVCTAPPAAVAKAAHAADLRLRLTPTGGARTCAQLRTRQRPAPGRPPVRVPGRAPGRWPRGRTAAGEAPSPDALLAAAAAMTRGEGWPAVALYAVDGAAGIAVYRGGERTAEFTWRASGTAVAATVRDVAQSASPGGGGAAPGSPERAPRGGTGRVAQFAEVRDTAEAIAAALAVADARPLTGVLRTAGTRRPRSTLAEALQALDLAALAPLFAPTPADPPSRPTTPQAGPDPIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NA93</accession>
    <name>A0A0F7NA93_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Peptide ABC transporter ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_17030</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016936.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_17030"/>
    <dbReference type="EnsemblBacteria" id="AKH83632">
        <property type="protein sequence ID" value="AKH83632"/>
        <property type="gene ID" value="AA958_17030"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_17030"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3581"/>
    <dbReference type="OrthoDB" id="1303270at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="19"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="314"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="268"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="268"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="53"/>
            <end position="60"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="352"/>
            <end position="359"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH83632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="583" mass="62159" checksum="8AEEAB0380F4272A" modified="2015-07-22" version="1">MTGHGQEKEGTAPEPVLSVERLSVDFRVAGEWTPAVRDVSFTVGRGEVVALVGESGSGKSVSSMSVLGLVAGSAQHRGSIRFHDTELLGLGHEALRGIRGKRIAMIFQEPMTALNPVYTVGRQIAEAIRCHEKVSAAGARARAIELLTKVGIPEPERRVDSYPHQLSGGQRQRAMIAMAISGSPEVIIADEPTTALDVTVQAEILELLRGLRRDLGSAVLIITHDMGVVADIADRVVVMKEGEVVEEAPVGRLFAAPEHEYTRRLLAAVPKPPPPPATPSPPPATPPPPPATPPLAGVPPLAGVPPLAGEDTTLRIRDLEVEYPGRLGRKGFKAVHGVSLTIGKGEVLGLVGESGSGKSTIGRAVVGLSRATGGSVEVCGTDVTGLSGRPLRAFRPTYSMVFQDPGASLNPRWSIGDSIAAPLLVNRRADRAAAHSRVAELLEQVELPAHWASRFPHELSGGQRQRVGIARALALEPELLIADEPTSALDVSVQATVLRLFRELQDRLGFACLFISHDLGVVELLAHEVAVLQNGRLVEHGPAREVLANPRTEYTKRLVAAAPVPDPEQQAERRRLWREMAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAB2</accession>
    <name>A0A0F7NAB2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CopY family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_17160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BlaI transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016956.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_17160"/>
    <dbReference type="EnsemblBacteria" id="AKH83652">
        <property type="protein sequence ID" value="AKH83652"/>
        <property type="gene ID" value="AA958_17160"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_17160"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3608"/>
    <dbReference type="OrthoDB" id="2027769at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005650">
        <property type="entry name" value="BlaI_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34134">
        <property type="entry name" value="PTHR34134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03965">
        <property type="entry name" value="Penicillinase_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019455">
        <property type="entry name" value="CopR_AtkY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="128" mass="14515" checksum="6AD24A05105421ED" modified="2015-07-22" version="1">MRRLGDLEAEIMDRLWKWERPATVREIVDDINNDRELAYTTVMTVANILYQKGWLVRTKQGRAWLYTPVRSREAYSAALMEDALGASEDRSAALAHFVDGMTDDEVAALRKALRESDAGRRCEGRGPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAR0</accession>
    <name>A0A0F7NAR0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcription termination/antitermination protein NusA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">nusA</name>
        <name evidence="10" type="ORF">AA958_26295</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Participates in both transcription termination and antitermination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the NusA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018397.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_26295"/>
    <dbReference type="EnsemblBacteria" id="AKH85156">
        <property type="protein sequence ID" value="AKH85156"/>
        <property type="gene ID" value="AA958_26295"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_26295"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5536"/>
    <dbReference type="OrthoDB" id="384865at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3 7" id="KW-0889">Transcription antitermination</keyword>
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        <location>
            <begin position="115"/>
            <end position="180"/>
        </location>
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        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
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            <begin position="60"/>
            <end position="78"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
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            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022814"/>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AKH85156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="328" mass="35723" checksum="63CDD4F3840FFEA6" modified="2015-07-22" version="1">MDIDMSALRGLVREKEISFDLLVEAIESALLIAYHRTEGSRQQARVELNRETGHVTVWAKEDPDDVPEGGEAREFDDTPSGFGRIAATTAKQVILQRLRDAEEEITFGEYAGREGDIVTGVVQQGKDPNNVLVDIGRLEAILPVQEQVPGEEYKHGTRLRTYVVRVTKGVRGPSVTLSRTHPNLVKKLFALEVPEIADGSVEIAAIAREAGHRTKIAVRSTRSGLNAKGACIGPMGGRVRNVMAELGGEKIDIVDWSDEPADLVANALSPARVTKVDVVDLAARSARVTVPDYQLSLAIGKEGQNARLAARLTGWRIDIRPDTEQPAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAS4</accession>
    <name>A0A0F7NAS4_9ACTN</name>
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        <submittedName>
            <fullName evidence="2">Nucleoside-diphosphate sugar epimerase</fullName>
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    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_23040</name>
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    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="6"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="283" mass="29751" checksum="E3AF62F9967B220F" modified="2015-07-22" version="1">MILVTGATGRVGGQAVAQAHWAGLPVRALVRDPARADFPEGVEAVRGDLADPATLGPAFAGVSAVFLVWPLPTADTAPAVLDAAHAGGVRRIAYVSAWGASDDPEEEPEGILGFHTAIERLLRASPLEWTLLRAGGFAANTLHWADQIRAGDVVHAPYGEAGRSLIHEADVAAVGLRALTHEGHAGATYHLTGPEVLTQAEQVRTIGEALGRDIRFEESPPEVAREAYVAAGLPPSFADGILAAHAELVKHPEPVTETVAEVTGHKARTFAQWARDHRTDFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAX2</accession>
    <name>A0A0F7NAX2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    </gene>
    <organism evidence="2 3">
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        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH85266">
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        <property type="gene ID" value="AA958_26915"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_26915"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5661"/>
    <dbReference type="Proteomes" id="UP000034283">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="98" mass="10317" checksum="7439EFD33FE5F165" modified="2015-07-22" version="1">MAPTLTTPAPAPMIVPYTPMLEARNAATIVADAPPATWAPLSSIFPLRFSSPPSSAVLSAVPRISIPRSLRWAPALMDERTDGPVSSDSGDSVMQRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NB02</accession>
    <name>A0A0F7NB02_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">4-hydroxythreonine-4-phosphate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_27200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_27200"/>
    <dbReference type="EnsemblBacteria" id="AKH85306">
        <property type="protein sequence ID" value="AKH85306"/>
        <property type="gene ID" value="AA958_27200"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_27200"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5731"/>
    <dbReference type="OrthoDB" id="1414545at2"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005255">
        <property type="entry name" value="PdxA_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30004">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00557">
        <property type="entry name" value="pdxA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH85306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="362" mass="37094" checksum="CE673320C8CBFF88" modified="2015-07-22" version="1">MNDPQVPTLALTLGDVAGIGPEITARTLLHHDELRGVSRPVVIGDADAVRRAVALIGEDPGAVRVVDSPRDAGNEPGTIDLVQDGPSLGAVPYGELSAAAGDGSARFVKRACALAREGLVDGIVTAPLNKAAMHAGGHLWPGHTELLAHEFGVENFSLVLSAGELYFFHLTTHVSLTEAIAGVSPARTDNVLRLVGSFARALGLPEEPIGVAGLNPHAGENRLFGDEDADVLAPAVERANAAGIRAVGPLPADALIPAAVKGAWKFVVVCYHDQGHAPFKAVYGDDGVNITVGLPVVRVSVDHGTAFDIAGKGVAREASLVLATRRAAELAAGWGQVWRTAQAGESAAASAAAAVERPGTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NB10</accession>
    <name>A0A0F7NB10_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_18440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017155.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH83857">
        <property type="protein sequence ID" value="AKH83857"/>
        <property type="gene ID" value="AA958_18440"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_18440"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3871"/>
    <dbReference type="OrthoDB" id="1814721at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH83857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="115" mass="12509" checksum="5BEC0CD511BD2B35" modified="2015-07-22" version="1">MADAGQSGQSWQRTFKGLPEEARAVRCWTSDRISNANAPQVVHEMFLIALACLPDSIEVTLSTAGDRVRITVMGPCELRLKDVYGPGRRIIHALSDGLSGTTADGHGLWAQFVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NB46</accession>
    <name>A0A0F7NB46_9ACTN</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_18765</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH83902">
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        <property type="gene ID" value="AA958_18765"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_18765"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3936"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH83902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="121" mass="13766" checksum="2EEF534BD0DB7168" modified="2015-07-22" version="1">MTVGRNGIFGRWGDHLGRALEKSSFQRRLNEFDDSAWQRMDDLVIFWADMGGADEFLTLETSHREGVEYLVQRQLRVLLARGNPPLNVISKVRSNRTVQLPLVQTAANQVVGHFQAHFDAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-10-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NB88</accession>
    <name>A0A0F7NB88_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH gntR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_19165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017252.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH83957">
        <property type="protein sequence ID" value="AKH83957"/>
        <property type="gene ID" value="AA958_19165"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_19165"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4029"/>
    <dbReference type="OrthoDB" id="1796334at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="14"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="326" mass="34644" checksum="870E52D7CE9BABD9" modified="2015-07-22" version="1">MSEVNIAVNRTLGIPLTTQIRNQIVNAITTGDLQPGQRLPTVRQLAEFLGINRNTVGQAYRQLENDGHVITRAGGGTTVAGDPSITTPTPDTLQDLVRNALAQACSAGFTAREFAELVHHTSAQEDTAPASRILVIDDYRGELDFVCATIRRALPGSTVDAALVADLRASGPEELRARLAGFDCALVAFYCLEKVRPLLTEANLPIVAAGIGPTLNSLRRIADECTGKQTAIVCTEPNGPAHMAAALRRAGVTFTAAPRLAHVHDQDLTQILAACDVVIASQGSADAVAHLAHDIPIIPYSRLISEETLATLRSYTDYLAANTAQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBF9</accession>
    <name>A0A0F7NBF9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_24205</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AfsR/DnrI/RedD regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018055.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_24205"/>
    <dbReference type="EnsemblBacteria" id="AKH84803">
        <property type="protein sequence ID" value="AKH84803"/>
        <property type="gene ID" value="AA958_24205"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_24205"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5100"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15831">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03704">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="69"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="69"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="55"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH84803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="352" mass="38308" checksum="F7EC9355E8150F38" modified="2015-07-22" version="1">MGTGTGDARRIAELEREVQELRRANEILKVYFAKELDLELESTPSALVVGAPSGPTLPEAPPAAPPAPSRPIRWGAAQPAMSPDPSRPMAEFRALGPIEAVVDGRLLDLGAPKQRALLALLVSKVGQPVAVDVIVEELWTGNPPPSAITSLQAYVANLRRVLEPNRAPRTPATVLRTYGRGYLLDNHVVEVDVHRFSERAGAGWEALDRGKPQEALRELEAGLMLWRGQAYAEVADTTYVRPEVARLEELRLSVIEGRCAALLAVGAHEMAVAELEAFTQAHPLREYGCELLSLALYRAGRQADALAVLRTNQRRLAEELGIDPRPALQHLENEILNHAPALDWRPRPGGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBL6</accession>
    <name>A0A0F7NBL6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_28750</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018804.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_28750"/>
    <dbReference type="EnsemblBacteria" id="AKH85571">
        <property type="protein sequence ID" value="AKH85571"/>
        <property type="gene ID" value="AA958_28750"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_28750"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6059"/>
    <dbReference type="OrthoDB" id="191097at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007165">
        <property type="entry name" value="Phage_holin_4_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04020">
        <property type="entry name" value="Phage_holin_4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="152"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="182"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="376"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="602"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="613"/>
            <end position="631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH85571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="829" mass="87036" checksum="7A5FB9F6F7A74AD0" modified="2015-07-22" version="1">MAEPRKAPGGYSGPGEEPESGEGAGEGTRPGPDPRSGPHAGSRADPDPLSRTEPGPESGTEPDGRSPAEPGHEPGTEPDDPFRTDEDDPPRTGSGSRAGLTALRAAATRRGRRAAARGLGRIVVVWAVGTVTMLILAGALPDFRLQAPGGDSATHIAVTAAVGAGVFGVLSALVWPVLVRALLLVPAFVLGLLVFFLNGSLLLIALSLNPTGRGEANPETAVVVAAVMSAASSATSTALTVRDDGAYRRRLARLAYRRGAPAVSPDAAPGIVFLQLDGVGHDVLHAALQERERAGGRSLGGQRLLAHRLPPVMETVASWHGTSHRLIPWRTDWSSQTGASQLGILHGTNEDVPAFRWYEKETGEVMVCSHPSTAQELERRAASRTADPAAPGGLLATGEPGDTASRGNLFTGGATQLALVLSVAVRRNKKTRSRAGYFAYFSDPANASRTFASFVAEAVREVFQSLRSRLRRETPRVGRGGLYPFIRAFATVVSRDVVVASVIGDMLAGRTAVYADLVAYDEVAHYAGPHHRDTQQVLRRIDRSIALIAKAAEHAPRPYRIVLLSDHGQSHGPTFAAAYGLTLQDLVRAGCGLPVSRRVGKTRSGAEARTAARAALRRPERPEDGHGGEGRRGLEPVVLASGNLGLVSFPELPGVASRETIERRHPALLPALTEHPGVGFVLVRSGEHGPVVLGADGAEHHLETGKVVGIDPLLPFGPGAAGTVLRTARFPHAADIMVNSSYDPQTGTVHAFEDQIGSHGGLGGEQSRAFLFWPEGLTPPVPAGETLAGAESVHRVLRRWIGECGGPVVRRAAAAGVRAEPVAEDQRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBZ7</accession>
    <name>A0A0F7NBZ7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">UDP-glucose 6-dehydrogenase</fullName>
            <ecNumber evidence="4 7">1.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AA958_25195</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>H2O + 2 NAD(+) + UDP-alpha-D-glucose = 3 H(+) + 2 NADH + UDP-alpha-D-glucuronate</text>
            <dbReference type="Rhea" id="RHEA:23596"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="1.1.1.22"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nucleotide-sugar biosynthesis; UDP-alpha-D-glucuronate biosynthesis; UDP-alpha-D-glucuronate from UDP-alpha-D-glucose: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.22" evidence="4 7"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018209.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_25195"/>
    <dbReference type="EnsemblBacteria" id="AKH84958">
        <property type="protein sequence ID" value="AKH84958"/>
        <property type="gene ID" value="AA958_25195"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_25195"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5310"/>
    <dbReference type="OrthoDB" id="647136at2"/>
    <dbReference type="UniPathway" id="UPA00038">
        <property type="reaction ID" value="UER00491"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003979">
        <property type="term" value="F:UDP-glucose 6-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006065">
        <property type="term" value="P:UDP-glucuronate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017476">
        <property type="entry name" value="UDP-Glc/GDP-Man"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014027">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036220">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014026">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001732">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028357">
        <property type="entry name" value="UDPglc_DH_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00984">
        <property type="entry name" value="UDPG_MGDP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03720">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03721">
        <property type="entry name" value="UDPG_MGDP_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500134">
        <property type="entry name" value="UDPglc_DH_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000124">
        <property type="entry name" value="UDPglc_GDPman_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00984">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52413">
        <property type="entry name" value="SSF52413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03026">
        <property type="entry name" value="NDP-sugDHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 10" id="KW-0520">NAD</keyword>
    <keyword evidence="5 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDPG_MGDP_dh_C" evidence="11">
        <location>
            <begin position="327"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="160"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="260"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="271"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="334"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AKH84958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="446" mass="48004" checksum="49BE3CF7B3D8720D" modified="2015-07-22" version="1">MSLRITVIGTGYLGATHAAAMAELGFEVLGLDVVKEKVELLSAGRVPMYEPGLEELLRTHVAGVEGATGRLRFTTDWDEVAAFGDVHFVCVNTPQKHGEYGCDMSYVDAAIDTLAPRLDRPCLVVGKSTVPVGSAARLARRLAELAPAGEEAELAWNPEFLREGFAVEDTLRPDRIVVGVASERAEELLREVYAGPVGDGTPFVVADYPTAELVKTAANSFLATKISFINAMAEICEAAGGDVVKLAEAIGYDDRIGKKFLRAGIGFGGGCLPKDIRAFMARAGELGVDQALTFLREVDSINMRRRAHMVELAREACGGTFLGRRIAVLGAAFKPDSDDVRDSPALNVAGQIHLQGGQVTVYDPKGMDNARREFPTLRYADSAEDAAGSADVVLHLTEWSEFRNLDPRRLARAVATAHLIDGRNTLDPAPWRAAGWTFRAIGRPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NC23</accession>
    <name>A0A0F7NC23_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidoglycan-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_25365</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018240.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_25365"/>
    <dbReference type="EnsemblBacteria" id="AKH84989">
        <property type="protein sequence ID" value="AKH84989"/>
        <property type="gene ID" value="AA958_25365"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_25365"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5346"/>
    <dbReference type="OrthoDB" id="1891666at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008258">
        <property type="entry name" value="Transglycosylase_SLT_dom_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01464">
        <property type="entry name" value="SLT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519479" evidence="2">
        <location>
            <begin position="42"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="3">
        <location>
            <begin position="69"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH84989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="250" mass="25903" checksum="C398D8469013B50B" modified="2015-07-22" version="1">MPARGKHRRPKLRLIGRGITFAGVSGVAIAAPLIGASSASAAGSVPASAPQTGVRAEAPAAATTGAAAATYAVVAGDSLAKIADKEGVRGGWKKLYKDNREAVGDNPHFILPGLELSLGAKADTSEPKESESGLKTTSASVTSYPDNLDGWIRESLDIMAEHGIPGTYDGIYRNIMRESAGDPQAINNWDINAVNGTPSKGLLQVIAPTFDAYHVPGTSTDSFDPVANITAACNYAADRYGSIDNVYGPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NC76</accession>
    <name>A0A0F7NC76_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_25490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018264.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_25490"/>
    <dbReference type="EnsemblBacteria" id="AKH85013">
        <property type="protein sequence ID" value="AKH85013"/>
        <property type="gene ID" value="AA958_25490"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_25490"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5372"/>
    <dbReference type="OrthoDB" id="2015162at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH85013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="79" mass="8663" checksum="14BF9D5455081083" modified="2015-07-22" version="1">MSKFAKAKDFKKSKTGVYISLTSTLFGVISVAKQMKQARFEEDRLRQLDAAVSAAAIATGVALLVRELRRMNDDDILAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCR0</accession>
    <name>A0A0F7NCR0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Peptide ABC transporter ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_26340</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018404.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_26340"/>
    <dbReference type="EnsemblBacteria" id="AKH85163">
        <property type="protein sequence ID" value="AKH85163"/>
        <property type="gene ID" value="AA958_26340"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_26340"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5545"/>
    <dbReference type="OrthoDB" id="1101128at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="4"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH85163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="325" mass="34360" checksum="D97B4700656D65A9" modified="2015-07-22" version="1">MTLLELRDLHVTYGTGAAAVPAVRGVDLSLAAGQKLGLAGESGCGKSTLALALLRLLPRSARLTGEILLDGEDVLTMPWGRLRAVRWAGASIVFQGAMHSLNAVHRIRDQIAEPILLHRLETSPGAARRRAEGLLEQVGLPAARGGAYPHELSGGQRQRAMIAMALACDPRLIVADEPTTALDVMIQAQILRLIERLVADQGISLLMISHDLAVLSDTCDRLAVMYAGRIVEEGPAQTVFTAAEHPYSGALAAAFPAVGRAADRRAPQGLPGDPPDPSRLPPGCAFHPRCPVALETCAAADPRLREAGPGRRAACVHVDSVKEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7ND62</accession>
    <name>A0A0F7ND62_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">FtsX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AA958_32545</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_32545"/>
    <dbReference type="EnsemblBacteria" id="AKH86166">
        <property type="protein sequence ID" value="AKH86166"/>
        <property type="gene ID" value="AA958_32545"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_32545"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6869"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038766">
        <property type="entry name" value="Membrane_comp_ABC_pdt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30287">
        <property type="entry name" value="PTHR30287"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="232"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="276"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="327"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="379"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="403"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="451"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="688"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="737"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="777"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="8">
        <location>
            <begin position="716"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH86166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="814" mass="84748" checksum="AFB97149F33C8D0B" modified="2015-07-22" version="1">MASAIAAGIGGVLLTTAMLLVSVSVLDAIKGASISGIRPDVVAVEARAPGGMDSSLMDRAEQRTGAEGSRSVVLSTTAQTSAGSDNEPVVLFGVDEALAGFVDDQLAAEVGGTPLGADEVFLSETWAGDHGVREGDTVRISSPEGVQTWRVAGLLSGDVANRGSVVIAPLPTVAAAFDRGDTADVLLLDPGNGDRDTVAAEAEAAVDGAADVKHPEDLLSGYSKTFQTSVTILALFAVIAVLTAAVVLFLTWRLALDDARSTLARMRLFGVRTRHLMLGSAAVMVPLLLGTYVVGAALGVWVGTLLSSFTEQITNLTGQAVTPGVPWQVPVAGAFAAAVVMFAAAWLSGVRRFTAITAIEAVTGRDRIALMPGGTRRPLVAGLVTVAIGVLLVAFGGEMVRSASLLFLLGGAALLCVVLPVVVGALLRRGEPGPMRLGAGRQLQLSWRRNAVLSITFTVAVVTSIAMAGVSSSIKDDVGASVDRWTQSELVVQAAGVGENLQNEKFPLSLGQELGAVDGVDGVTPFTYAYVTLDGKKTQVWNWPSDHELSTDLEVAEGEEDFLTALGPDEIAISSNFARTQDMEVGDTLDMPLPSGQRALRVRTIVEDSASDGGMLIASTALYRELAATDGVYEYFVGVREGADVSEVAATLENTVAERYPRAKVRTQEEVRAAFGGITARLVSAFEAFAWVMFLLAVMVGGATLASGLVERQRGLALTRLVGATRKSVSRQLTAETLLIAVSSWVVALPVGLLAIPAMLDAQAGQSGLLPPVTVPLLLTVASLPLVALCMLLALWVAGPRRANPPLRELLAQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7ND96</accession>
    <name>A0A0F7ND96_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_00180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_00180"/>
    <dbReference type="EnsemblBacteria" id="AKH86455">
        <property type="protein sequence ID" value="AKH86455"/>
        <property type="gene ID" value="AA958_00180"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_00180"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.41"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="560" mass="59587" checksum="7452DFFDD61ECE36" modified="2015-07-22" version="1">MSTLQTLRGSIAALIQLTGGSKAELAAGIGLSPEAVSRRQNGHTAWSLDETDAVAAHYHITALSLLSGPTAAVEAVPAHRRDLRHKTAPRPATASAPPDAPAEKAEKAEALAVQRPPAPEPMRPCVLCGGPASDVVEGFPQHLDPGDCTPPQSSPPAPAAAHPVPGEAGERPYSVPAATASRADATAFAGIPSQTSPAPAPAPAPAPAPAPGTVQPQRPVAAARPAIGADRRPRTSSTDQLPVDEIHQLVVDEATKAGGDLEAATAALIKRAIPDAMALWGLTRVGSTYDVLFRPPRPDILKKRTRNGADDIWEARPKWRNAALLSDSTGPVREVTALDVNGAFLAALKTHLPHKVLAHDTSGTYDRRRSGVYLITPPHWPHEQLPNPLGDRDLVGELWITDATLRLLLRVSGPKFQLCEPPVVHESWTAAASENLLEKFRQTLAAARHEAITGGDQMTVEYVKAMYSKFVSTCGESSHNRDIERPEWMHIIHSQAFANLWWKAHRAYAAGLSVVKMTGTDELHVTGGDWRAVFPEGRGLSEVKEKHTYTIGGSGSMGEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDE7</accession>
    <name>A0A0F7NDE7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VMAP-C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_23900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017999.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_23900"/>
    <dbReference type="EnsemblBacteria" id="AKH84747">
        <property type="protein sequence ID" value="AKH84747"/>
        <property type="gene ID" value="AA958_23900"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_23900"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5036"/>
    <dbReference type="OrthoDB" id="1779699at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045450">
        <property type="entry name" value="VMAP_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20028">
        <property type="entry name" value="VMAP-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VMAP-C" evidence="2">
        <location>
            <begin position="496"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH84747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="740" mass="79075" checksum="DA91CD2EEF63780A" modified="2015-07-22" version="1">MRVPIESSEAAEYARYQLCKLAAAATVDIRAAPGADDGSLWGSGFLVAPEWVLTCAHVFVHPDGWRRGTAPGELIGVVVGGRTVPGRVEYSMPSPDGTAARMGRDPEVRDETFAEAVMQVGPDLALVRLLPLRAEGVGTGAPGGEARYGLPYAALSGAQTGLQPGGQPGALPGARSGAQPVADRGHPARPPADSEPVWLGDRYDDFLDQAVLLSAHGRAAGSGEDVDAALLSAEFAGRNGQQILLGTPTPIRRGASGGPVLHLGRGEVVGVVKARYRSGTGGGTAVSLDELHALSPEHLLPGATGLGPEPYRELMRLHDAWHWHRHHGIDDERTSWTDLQRALGPARFGAWGALDRLSALWRLADLPAPRDPEVVERLVHQVLDIQGRPLGARRLRDWRDGHGLLHRHAAPERALRDMLLYLKLVAREAAAGIGAGEGVGSRTAVESLESWVAERAGELPPRQRQEIRAVRRAPVSVLVTFDKLPFLDPAAGSVPRYNWTVRRGYGKGEWEHVALDQSYAGGSFEEAEAQVLQALAPQLLGADAEAQTRVRLEVALPEERQAHPTYRWELPASGRATAARPPAGTVRPVVHRDAARAGPEPEPLWRDRWRRMSRAPRQRLVRAAPPGWGRGAGDGGVPVFCHALGDGSGRAAVVGQLLDEGTAVALWRAGGHRDEECGEECAAYHEELAALLADGAGTVVRDLPERLHEVRREALEAGRGCAADVILFYDDADDTIGAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDQ4</accession>
    <name>A0A0F7NDQ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Beta-N-acetylhexosaminidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_28465</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018757.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_28465"/>
    <dbReference type="EnsemblBacteria" id="AKH85523">
        <property type="protein sequence ID" value="AKH85523"/>
        <property type="gene ID" value="AA958_28465"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_28465"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5998"/>
    <dbReference type="OrthoDB" id="1158117at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016231">
        <property type="term" value="F:beta-N-acetylglucosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011496">
        <property type="entry name" value="Beta-N-acetylglucosaminidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015882">
        <property type="entry name" value="HEX_bac_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02838">
        <property type="entry name" value="Glyco_hydro_20b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07555">
        <property type="entry name" value="NAGidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="SSF55545"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519340" evidence="4">
        <location>
            <begin position="29"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="5">
        <location>
            <begin position="642"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="24"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="24"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH85523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="902" mass="94565" checksum="B7B5DA25CDE2F943" modified="2015-07-22" version="1">MPVPRPAVVGAVLLALGLSPLAAPPAAGAPPPPARAGDISPTPRSVEARADGVTVTRTVTLVTGPEPDGPALAVAEKALRDAGAEDVRRTATAPDEGRGLTVYLGGPDANPASAAALGALGVEGPAGLPADGYVLAAGTAEPAGGTPGGDGIVLAGADASGTYYAAQSLRQLLPHRDSPGTRVAGTAVRDWPGTGWRGAIEGFYGVPWSHASRLDQLSFYGEHKMNIYVYSPKDDPYLRERWREPYPADELARIAELVERARANHVEFTYALSPGLSVCYSSDADVQALNDKFQTLWDIGVRTFAVPLDDISYTDWNCAADEERFGTGGGAAGAAQAHLLNRVNREFVRTHDGAEPLQMVPTEYYDTTPSPYKKALAEQLDEDVLVEWTGIGVVAPVMTVAQARDAREVFGHPILTWDNYPVNDYAQQRLLLGPFNGREKGLPGELAGITANPMNQAAASKLALYTVADFAWNDAAYDARESWAGALAELAGGDRHTTAALRAFADASYGSALNPGQAPELSAAIAAYWDRGGEDALDDALAALEAAPGVLRDRLPDRAFVEESGPWLDATRDWGTATRTALRMVEAARDGDGDRAWRLRQRLPELVDQATSHIYTGLGGREVKVVVGEGVLDAFVADAAAAHDRSLGLPPRPKGATNLGTYQGNTVDRMTDGDDSTFFWSDGAPRAGSWVSVDLHGEREIGEVGLAMAKSGSPNDYLQQGVLEYSADGETWQELATFSGTPDVEATAPEGTKARYVRARSTAAQGNWLVVREFTVAGGGPATTAGGPPAAEGSSLAAAADGDTASVYRAARAPQAGESLDIRFAEPRAAKSLIVLRPQDAPNAGATVQIRNEPDGPWRTAGTLAGAYTELRVPGGAVAEVRLRWSGGGAVPQITDVGVAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDT6</accession>
    <name>A0A0F7NDT6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_24440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018089.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_24440"/>
    <dbReference type="EnsemblBacteria" id="AKH84837">
        <property type="protein sequence ID" value="AKH84837"/>
        <property type="gene ID" value="AA958_24440"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_24440"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5150"/>
    <dbReference type="OrthoDB" id="1809950at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="156" mass="17231" checksum="1F54E38C561B3F50" modified="2015-07-22" version="1">MAAIAEIYTYYVTDTVITFEETPPPPAYWQQRLRDLSDRGLPFLVAEADGSLAGYAYAVPWRPKPAYRHTVENTIYLAPGRTGQGIGGALLAELVDRCAKADVRQIMAVIADTGDGTSPALHRRHGFTQVGRLTEVGFKHGRWVDTILMQRTLRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDW8</accession>
    <name>A0A0F7NDW8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HxlR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_10875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019949.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86680">
        <property type="protein sequence ID" value="AKH86680"/>
        <property type="gene ID" value="AA958_10875"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_10875"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2287"/>
    <dbReference type="OrthoDB" id="2057904at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="1">
        <location>
            <begin position="10"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="121" mass="13021" checksum="FA0F228FCB6937A8" modified="2015-07-22" version="1">MTTDAFLADCRARLAFDLLSNTWNAVVLWALRDGPRRPVELRARIGGISSKVLTETLRRLQFNGLVERDVRPGAAGRVEYGLTELGESLLTPIGAFGAWAFAHGDEVMAAQEASCASSGEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NE15</accession>
    <name>A0A0F7NE15_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Beta-lactamase</fullName>
            <ecNumber evidence="2 4">3.5.2.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_01360</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a beta-lactam + H2O = a substituted beta-amino acid</text>
            <dbReference type="Rhea" id="RHEA:20401"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:35627"/>
            <dbReference type="ChEBI" id="CHEBI:140347"/>
            <dbReference type="EC" id="3.5.2.6"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the class-A beta-lactamase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.6" evidence="2 4"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_01360"/>
    <dbReference type="EnsemblBacteria" id="AKH86481">
        <property type="protein sequence ID" value="AKH86481"/>
        <property type="gene ID" value="AA958_01360"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_01360"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.300"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008800">
        <property type="term" value="F:beta-lactamase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030655">
        <property type="term" value="P:beta-lactam antibiotic catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045155">
        <property type="entry name" value="Beta-lactam_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000871">
        <property type="entry name" value="Beta-lactam_class-A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023650">
        <property type="entry name" value="Beta-lactam_class-A_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35333">
        <property type="entry name" value="PTHR35333"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13354">
        <property type="entry name" value="Beta-lactamase2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00118">
        <property type="entry name" value="BLACTAMASEA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00146">
        <property type="entry name" value="BETA_LACTAMASE_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase2" evidence="6">
        <location>
            <begin position="58"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH86481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="295" mass="31453" checksum="D2B37337A6B57C25" modified="2015-07-22" version="1">MTSAACSDGSRTTAAPDHRAAPSAPAAGAAQQRATREFKDLERAHDARLGVYAVDTMTGQEVAYREGERFAFASTVKAFEAGAVLRKRKLAGLKKEITYDRSDLVANSPITEKHVDDGMTLGELCDAAVRYSDNAAANLLFEEIGGPRALQSFLRETTGDDTSRMERIEPALSDWEPDAVRDTSTPRALAGNLRAFVLGDVLDAPERARLAEWLRTNTTGDASIRAGVPKDWKVGDKTGTAATFGGRNDIAVVWRPDAAPLVVAVLSHGTDRDAEPDDELIAKAAAVVSDAMGAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NE28</accession>
    <name>A0A0F7NE28_9ACTN</name>
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        <submittedName>
            <fullName evidence="1">3-oxoadipate:succinyl-CoA transferase</fullName>
        </submittedName>
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    <gene>
        <name evidence="1" type="ORF">AA958_29265</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018882.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_29265"/>
    <dbReference type="EnsemblBacteria" id="AKH85653">
        <property type="protein sequence ID" value="AKH85653"/>
        <property type="gene ID" value="AA958_29265"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_29265"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6170"/>
    <dbReference type="OrthoDB" id="1660857at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008410">
        <property type="term" value="F:CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004165">
        <property type="entry name" value="CoA_trans_fam_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01144">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00882">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH85653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="271" mass="29396" checksum="E2D1EBBC5B098E95" modified="2015-07-22" version="1">MAEVRTLRDAVGELIHDGDTVAMEGFTHLIPFAAAHEIIRQGITDLTLVRMTPDVIYDQLIGAGLVRKLMFSWGGNPGVGSLHRFRDAVENGWPRPLELDEHSHAGMANRYVAGASGLPFAVLRGYAGTGLPDRTGTVSTVRCPFTGEELAAVAAVNPDVTVIHAQQADRDGNVQMWGLIGVQKEAALAARCVLVTVEEIVDRLEPRPGAVVLPGWTVTAVAEVPDGAHPSYAAGYSQRDNDSYQDWDPIARDRDAFTAWLDTHVRERAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NE40</accession>
    <name>A0A0F7NE40_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_25190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018208.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH84957">
        <property type="protein sequence ID" value="AKH84957"/>
        <property type="gene ID" value="AA958_25190"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_25190"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5309"/>
    <dbReference type="OrthoDB" id="1450979at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
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    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="384"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="443" mass="47629" checksum="3C29D95B5D40E9FF" modified="2015-07-22" version="1">MPTQPTPPSLVPTVPRGGRLLHIGPHKTGTTALQGAFHSARDRLPAYDVVYAGSKRQPVAAALAKIGVEFPGPAGTPVREELDVFLQRDRPGMERWRRLVRQCEEAGDRRTVISTEYFSNAGDDAAREVVAELGGGGRVHVVVTLRPLLKILPSQWQQYVRNGLRSSYEDWLEAMFHREPCIEPTPSFWRRHRHDQLIARWAAAAGPENLTVLVQDESDQQMQLRVFEEFAGLPAGFLVYDERDNRSMTHGEAELVRLLNEESHRRGWSVERHGKVVRAGALRRMRDKYQPGRDEARVTTPEWAVAEATELAGEMTTAIAALGVNVVGDLASLAKRPSAPAAPPAEATIPAAAAAQAVIGALLAQSSLDTRAAAEAAAPDTRAAAAAKDAARPNSSGSGASTATGTAAPTPEPAPADASAGGRGGATNPLRSAARRGLRRIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NE58</accession>
    <name>A0A0F7NE58_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_14010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_14010"/>
    <dbReference type="EnsemblBacteria" id="AKH86750">
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        <property type="gene ID" value="AA958_14010"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_14010"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2949"/>
    <dbReference type="OrthoDB" id="1337662at2"/>
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    </dbReference>
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    <dbReference type="InterPro" id="IPR029063">
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    </dbReference>
    <dbReference type="InterPro" id="IPR006764">
        <property type="entry name" value="SAM_dep_MeTrfase_SAV2177_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04672">
        <property type="entry name" value="Methyltransf_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017393">
        <property type="entry name" value="MTase_SAV2177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH86750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="266" mass="29154" checksum="B9E89C6F7C3B178B" modified="2015-07-22" version="1">MDNTVPHSARVWNYLLGGKDHYEADRRAADAYKETFPQITDIARTDRAFLGRAVHYLAAEAGIRQFLDIGTGLPTMNNTHEVAQRAAPSARIVYVDNDPMVLTHARALLTSTPEGSCDYIHADLRNPEAIVAGAADTLDFTRPVALTLLGILHFLRDYDEARRVVRRLLEAVPQGSYLAVTHATLDPSLGGTEVAAMNRRAQDQYNASAAVPLTPRTREEIEGFFEGLELIGPGVVSMSRWRPEPEETAEGTPPPVFGYCGVGRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NF00</accession>
    <name>A0A0F7NF00_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_31785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019267.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_31785"/>
    <dbReference type="EnsemblBacteria" id="AKH86039">
        <property type="protein sequence ID" value="AKH86039"/>
        <property type="gene ID" value="AA958_31785"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_31785"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6712"/>
    <dbReference type="OrthoDB" id="1906817at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007436">
        <property type="entry name" value="DUF485"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04341">
        <property type="entry name" value="DUF485"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="124" mass="13579" checksum="D34C9D7F930BA422" modified="2015-07-22" version="1">MEAAMSSTPPTGRSPDVYEEVQQSEEFGELRRAHRSFAFPLTIGFIAWYLLYVLLSNYAGGFMGTEVAGNINVAFVLGIAQFVTTFAIAWWYARHAAAKLDPRSEQLKAEVEGRVAGSGTEVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFL8</accession>
    <name>A0A0F7NFL8_9ACTN</name>
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        <submittedName>
            <fullName evidence="5">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_28315</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_28315"/>
    <dbReference type="EnsemblBacteria" id="AKH85497">
        <property type="protein sequence ID" value="AKH85497"/>
        <property type="gene ID" value="AA958_28315"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_28315"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5968"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="LuxR_C_like"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
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        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="4">
        <location>
            <begin position="216"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH85497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="284" mass="29739" checksum="D4381992E55E5E1C" modified="2015-07-22" version="1">MPETADAAEVRGALARLRRFGGVPVAFGGLLTDGGRKLRISELSGTVTPSLQGLGVATGNGLGGKAIAFSRPCAVTDYTSSRAISHEYDGPVGAEGLRSVLAVPVVVRGRVRAVLYGALRDSLPLGDRSLTAAVETARHLEQTLAVRDEARRLLAVATPTAQRAADPVAWENVRTAHRDLRTLAPRIADEELREELLALCDRLASAAVTVAPPAGAGPDRTVLAPRELDVLACVATGATNAAAGERLGLRPETVKSYLRSAMRKLGTHTRLEAVTAARRAGLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFN0</accession>
    <name>A0A0F7NFN0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_27030</name>
        <name evidence="2" type="ORF">AA958_28950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_27030"/>
    <dbReference type="EnsemblBacteria" id="AKH87052">
        <property type="protein sequence ID" value="AKH87052"/>
        <property type="gene ID" value="AA958_27030"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH87096">
        <property type="protein sequence ID" value="AKH87096"/>
        <property type="gene ID" value="AA958_28950"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_27030"/>
    <dbReference type="KEGG" id="strc:AA958_28950"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5688"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH87052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH87096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="184" mass="19925" checksum="ED3BC5831390D313" modified="2015-07-22" version="1">MSVVLRQGRHVVLFRRGGMRVPSVMGLLEARESAARVGVEELRAEADRVRVELVEAEAVLGRRVVALAELAEVLAAGVVLQEPVGPAPVPVEVKEPVAGSVVPVWREGVTVEVLAPEYRRLLAVLEAGSVGQGLRARDLAARLGLELVPSKVEGVRVKAKRLVARGWLAEERPGLFVLRCRRSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFX8</accession>
    <name>A0A0F7NFX8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_32965</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_32965"/>
    <dbReference type="EnsemblBacteria" id="AKH86233">
        <property type="protein sequence ID" value="AKH86233"/>
        <property type="gene ID" value="AA958_32965"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_32965"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6965"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="19"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH86233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="238" mass="25905" checksum="E711574D5381792B" modified="2015-07-22" version="1">MRADGRDEREVQAELARRLRLLRAERRLTMGGLERRAGLGHTTVSRALNGSALPSETTLVEPARALGADGGELLELRDRAQPPRARLAPPGGTAALFEERYRRYVAGRHGMLSVIGLDLSRPDRARWPLDAAYLSLELATPCTPPSPTAAPWPRAPATAPRSGWSAPSRRWRGCGGYWCGAWQAAARRRCSSGWRCRRQTERYRAGSASSAGACRSGCRCATAITGKSISRPCGTWPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NG50</accession>
    <name>A0A0F7NG50_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Beta-glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_33925</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019626.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_33925"/>
    <dbReference type="EnsemblBacteria" id="AKH86404">
        <property type="protein sequence ID" value="AKH86404"/>
        <property type="gene ID" value="AA958_33925"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_33925"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.7163"/>
    <dbReference type="OrthoDB" id="949956at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102483">
        <property type="term" value="F:scopolin beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="SSF52279"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fn3_like" evidence="2">
        <location>
            <begin position="740"/>
            <end position="807"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH86404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="819" mass="85855" checksum="AB6490EC392A9CB5" modified="2015-07-22" version="1">MTDRTATEPATAALRSLVGKLTLEQKVRLLTGADNWALHAEPAVGLRRIVLSDGPGGVRGESWDGRFTALNLPSATALAATWDPRIAYRYGAVIACEARRMGVDVVLGPTINLHRSPLGGRHFEAYSEDPLLTSRLAAAFVRGVQDGGVGATPKHYVANDAETDRFTVDNRIGARALRELYLAAFEDTVTGERPWMMMSAYNSVNGTTMSEHPLLAEPLCGEWGFDGVVVSDWWAVRSTEPAALARQDLVMPGPEGPWGGKLTAAVRDGRVPEEAVDEKVLRILRLAVRVGALEGFAPAVAAPPAGEDGPALAREVAAAGTVLVRNSGELPWSADGLRSVAVIGHLGFLPRTQGGGSATVEPARAVSPLEGLRAALPATRVDWHLGALAQRGIAPFAGSDLTDPVSGRPGVRLVCRGADGTVILDEHRRDANLARLGSARLAHTATVEVTARYLPARSGPVRIGVAGAGTLRLLVDGTELLREELVHTGEEFGGGLVSPPHASAPVELDAGRPVDIAVRLDLPPRRGPDSGVTLVAGLDLDTGAPDAEIAAAAAAARDADAALVVVGTGPEVESEGFDRTTLALPGRQDDLVRAVAAANPRTVVAVNAGAPVLLPWRDDVAAVLLTWFGGQEFGHALADVLLGTVEPGGRLPTTWPVDEADVPVLSTTPAAGRLPYDEGIRIGYRAWLESGTEPAYPFGHGLGYTTWAPPAAGIPGELAAGDDLLLTVALRNTGERRGKQVVQAYLSRPAGAVDRPVRWLAGHATVTAGPGQTATADLRIPARAFQHWDGAWRTEPGDFQVHLGFSSADLAVTGTVRIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-10-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NGE8</accession>
    <name>A0A0F7NGE8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_30510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH85832">
        <property type="protein sequence ID" value="AKH85832"/>
        <property type="gene ID" value="AA958_30510"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_30510"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6447"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH85832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="61" mass="6501" checksum="39AA5213D3C5A7A7" modified="2015-07-22" version="1">MQQSVPSVCAGGEAACTAAAVKGRGPWRTRDVGSAVPDVVLVAVRFRRGRPAPEPYRAEHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NGK5</accession>
    <name>A0A0F7NGK5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">5,10-methylene tetrahydromethanopterin reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_30685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019085.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH85857">
        <property type="protein sequence ID" value="AKH85857"/>
        <property type="gene ID" value="AA958_30685"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_30685"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6485"/>
    <dbReference type="OrthoDB" id="1434838at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019921">
        <property type="entry name" value="Lucif-like_OxRdtase_Rv2161c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03619">
        <property type="entry name" value="F420_Rv2161c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="20"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="274" mass="29783" checksum="57D2C66EE8B87F13" modified="2015-07-22" version="1">MKFGVSTFLTDEGIAPAVLGRALEERGFDALFVAEHTHIPVDRRSPLPAGGELPRKYYRTLDPFVALAAAAPVTRNLLLGTGIALVVERDPIVTAKEVATLDLVSGGRVAFGVGAGWNREEMRNHGTEPRTRGKLLDERMRAMIALWTQDEAEFHGEFVDFDPVFCWPKPVQRPHPPVYVGGGGEPAFERVAAFGATWLPSRVPPGELGGRMRRLREVAGDAPVVPYSASHEPAALETYAELGLERVLLDLPTLPEAESLRALDELASAAAAYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NH71</accession>
    <name>A0A0F7NH71_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_31925</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Antibiotic biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_31925"/>
    <dbReference type="EnsemblBacteria" id="AKH86062">
        <property type="protein sequence ID" value="AKH86062"/>
        <property type="gene ID" value="AA958_31925"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_31925"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6742"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043604">
        <property type="term" value="P:amide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901362">
        <property type="term" value="P:organic cyclic compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901566">
        <property type="term" value="P:organonitrogen compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020802">
        <property type="entry name" value="PKS_thioesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00824">
        <property type="entry name" value="PKS_TE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="953"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="988"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH86062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="2181" mass="230617" checksum="203EDA9AFADAB94D" modified="2015-07-22" version="1">MSRSLVEDVWPLSPLQEGMLFHAALAGTGPDVYTVQSALDIEGPLDPARLRASWQALLARHAALRACFRQVSGAKMVQVIAGDVALPWREEDLSGLTEDDARAELDRLTARRLAERIDLASAPLMRFLLVRLGADRHRLVMTFHHILMDGWSMPVLLTELSAVYAAGGDASKLKRVPSYGQYLAWLGRQDKDAARAAWRAELAGADEPTLVVPADPTRAAVFPEHVFGDVPEDVTKGLRDLARAEGLTLNTVVQGAWSLVLARLARRTDVVFGATAAGRPAELAGVESMVGLLLNTLPVRVRLDGGQPVTELLAGLQRRQSELMAHQHLGLPEVQRLAGPGAVFDTLVLYESFPPPPAGAGGPDALTIRPSGMSRDAAHYPLTLVVTPAGDRLRCKLDYRPDLFDPAAATAIFQRVVRVLEQVVADPSVRVGDVDVLAAGERTPVVSGWNATELAVPSGSVLDRFEARARRAPEAVAVRCGAEALSYGELDARANRLARYLQRLGVGRESRVGLCLPRGVEMIAAMLAVWKAGGAYVPLDPAYPAERLAFMASDSGAQVVLSTGELAPEGAVRLDEAAGEIAAESVEPLGTVPEPGQLAYVIYTSGSTGRPKGVAVPHRGPANLAEAMRPVLGMAEDVTALQFASFSFDAAVLDVAVTLAAGGTLAIASDEERVEPAALAGMVRSAGVSVASVVPSLMSALDPAAVTGVRNWVLGAELLTADLASRWTGQAKVWNTYGPTEATVITTATPLDADLTPADPPPPIGRPIGNTRTYVLDDFLRPVPQGVAGEVYIAGPGLARGYIGRGGLTAERFVACPFEPGTRMYRSGDLAAWTPDGQLAFRGRADEQVKIRGFRVEPGEIEAVLAAHPDVSRAAVVVREDRPGDKRLAAYVVPGGREADIDAVRAHAAARLPAHMLPAAVLALESLPLTPSGKLDRAALPAPDFAERATGRAPEGETEEALCALFADVLGVERVGADDSFFDLGGDSGLAMRLAGRIREDFGTELNMRQFFGSPTPVGVTRMLASKTRPALRAVEHPDEVPASAGQVRTWLMSRLAEDSAAYRTSVALRLTGELDRYALRAALGDVAARHDALRTTFAAEGGADLWQRVLGPAAARPAPEVVPATEAELPELLAARAAHAFDLTVEAPWTQTLFTLSETEHVLLLVVHRIAADDESLDVMLRDLSAAYGARREGRTPERAPLPLQFADYALWERELLAGEDDPESLISDQLAYWKDTLAGLAPELRLPADRPRPQLATHRTGQVPLRVEGDVHERLTELDEAGEGAFTVVQAALALLLTRLGAGTDITVGALLPRRDEEGALEGVVGPFAGPVALRTDTSGDPTFRELLGRVREANLEARRHQDLPFERLVDVLELPPSAARHPVMQVMLDVRDGTTGEEDTSELPGLSTGRLDLGPAASELDLSVSLSEWYRADGSGDGLDGHLRYAAELFDADTAAALARRLVRVLRQVADDPDVRLGDVDVLLDPAEHHRIVREWNDTAAPRPDTTVVGLLAGRAARPPDAVAVTDQDGALTYGALDTASGMLARRLAARGVGAEDVVAVALPLGARLAVALLGVLKAGAACLFTGPDRPMQALAPLRGHRPGALICTATTAGLLPADHAMTVVPLGNPVLAAARGTYAGPGPDGETGTAVPRPGHAALLLDSTTPHGVPAGVVVEHRSLVGHLADGADEVQDRAADEGPRHLTLDERAPVEAMVTPLLRALCAGESVLIGKPDPRAAHRALTTRDLLWTLAELPAGDPSFAEVTVIEDGAAASDVDAREWRARHPDAALVTGYGPAGTAGPWLHHRTAPGAPLPLEVPTGSLGPHTRAYVLDDRLRPVPPGAVGDLYVAGATLARGYHGSTRLTGEHFVACPYGPAGERMLRTGERARWSTAGLLTVRDRQAEEHDAALAQARRPEGGGDLGVLLPLRQEGSGAPLFCVHSATGLAWSYAVLVPHLPRDRPVYGIQARGLAGPEPMPKSVAEMAADYADEMRTVQPEGPYHLLGWSFGGMLAQAVAARLEEQGERVELLALLDAYPDGGAGTSLFSNEDAAGRAAAASAPRGRLLGPGGDEAAVPGVSGRLRSRMDQVMRNSAGFAPEHTPRRTTGDLLLFVATEDRPAGLPVADAVESWKPYVAGNVEPHEIGADHFGMLKSAPAAHIGRILAERLGIPGGTTEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NI31</accession>
    <name>A0A0F7NI31_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Beta-ketoacyl synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AA958_29305</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_29305"/>
    <dbReference type="EnsemblBacteria" id="AKH87109">
        <property type="protein sequence ID" value="AKH87109"/>
        <property type="gene ID" value="AA958_29305"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_29305"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6180"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901362">
        <property type="term" value="P:organic cyclic compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="1 6" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="1758"/>
            <end position="1833"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1741"/>
            <end position="1761"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="6">
        <location>
            <position position="1793"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH87109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="1883" mass="198962" checksum="91E5B8CEA77B7C6B" modified="2015-07-22" version="1">MAGRFPGAGDVETFWSGLAQGRVGITAFSDEELAASGVDPALLARDGYVKAKGVLEGADLFDEAFFGYSPREAELLDPQHRVFLECAWQALESAGVDPRGFDGRIGVFAGAGLNSYLLFNLMHNEQVRDAAGMYQVLLASDKDFLATRVAYKLDLTGPAVTVQTACSTSLTAVHLACQSLVNGECDIALAGGVSVSAPLRAGYAYEPGGILSPDGMCRAFDADASGTVAGNGAGIVVLRRLTDARADGDGVDAVILATAVNNDGSLKAGYTAPSVDGQADVVAEALALADIDPATVGFVEAHGTGTPLGDPIEIAALTRAFRTGTEDRGFCAVGSVKSNVGHLDAAAGVTGLIKTVLALKHEAIPPTAHYERPNPALELETSPFYVNTGLRSWPRGAEPRRAGVSSFGIGGTNVHVVLEEAPAGRPAGDATAEPPARLLPLSAKSAPALAEAAGRLADHLEAHPGTLLDAVAHTLARRRARFPHRTAAVARTTDEAVTALRLLAVDADSAVAAPDSAPVAFLFPGQGAQYPGMARGLHDREPVFAAEFDRCAALFAPYLEEDLRALVLAPDDPRTEKDAGERLRLTGFAQPALFCVEYALARLWQSWGVQPRAMAGHSVGEYVAACLAGVFSLEDAVRLVAARGRLVQKMPGGAMLSVFLPERETTARLGDGLSLAAVNSTALCVVSGLPEAVDDLERQLTAEGVGCRRLHTSHAFHSPAMDPVVQPFTDEVRGVSLHPPAVPFVSDVTGTWITDEQATSPDYWGGHLRQPVRFRDALGVLLADPALVLLEVGPGRTLTDFARAHRSWSPGRTAAGSLPHPGQDTRDDAHLMTNLGAVWSAGAAVDWAAVQGEERHPPLRLPGYPFQRRRFWVEPAGTSRGSQPAATTADDWFHAPGWQRLTLPARRATGPTGDVWVVLGAGLALGDALADRLAAAGDHVVRVTAGGGLAGAGDAWTVDPADRDGLTTLVSSLAGRLAGTGDEARLRFVHLWSTTADRAGDPPPGEPPTRERLEAARRTGFDSLLALAQALSSGERPTAPVTVDVVCRGVYDVTGEETLRPEHALLLGAATVIPQETADTACRVLDVTGTDPRAPHDDAVRALLTALTGMAGEPELALRGRHWWRRTFAAVPLGTDGTGLRDGGVYLITGGLGGLGLAMAEHIAATAERPVLALLGRSAFPEPGDWDAHLAAHGENDPVSLRILRLRRIQDLGARVHLLRADITDEEQTQRAVRELRAAAGPLNGVVHAAGSPSRGVIATKSPADADHVLAAKTRGLLVLDSACRDGDLDFMLLCSSVTGVLGGPGQSDYAAANAFLDAFAQWKRRETAVPVTAIGWDTWHEVGMAAGLGARFGAPPGAQAGGHPLIQRLVRSTPTSRTYATVFSTADSWIVRDHRIQEHGLVPGTAYLELVRAAVAEQAAGRDIEIGDVQYTIPVVVPEGQTREVFTTVEERDGHWHFLVRSRTGAAWHDHASGTVSFPDRAPDTVRDLAGLRAACEVKEVLDTQESITLGLGLDRFQKGGPIEFSFGPRWNCMREIAVGPRRVMATLRLDEEFHGDLDHYLLHPALLDAAGGTARVHAPGTYYLPFSYRSLRFHHGLTGTVHAHVELKESADATGETSTCDIEILDPEGRVLVRIGDFTIKRINDLDGLRDQIARAAEPPAPGHGTGGDGADEPAGTGILRTLAEGITEQQGKDAFARILAAPDLPGHLVVSHRDFTAVRDLARSLTPALLAREMDELAPPGATHPRPHLPTPYTAPRTPREQAVADVWQEVLGLDRVGVDDDFFALGGHSLAAVQIGTRLKSRLGTELDLRAFFERPTVAHTVEVLDSRAGAPAGGPDDAIEVLARDGADGTDLDALAHLTDDEVEARLRALLAAEGDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NIA0</accession>
    <name>A0A0F7NIA0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Transcriptional regulator WhiB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">whiB</name>
        <name evidence="14" type="ORF">AA958_23480</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="11">Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="11">The Fe-S cluster can be nitrosylated by nitric oxide (NO).</text>
    </comment>
    <comment type="PTM">
        <text evidence="11">Upon Fe-S cluster removal intramolecular disulfide bonds are formed.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the WhiB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_23480"/>
    <dbReference type="EnsemblBacteria" id="AKH86988">
        <property type="protein sequence ID" value="AKH86988"/>
        <property type="gene ID" value="AA958_23480"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_23480"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4950"/>
    <dbReference type="OrthoDB" id="1974660at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035731">
        <property type="term" value="F:dinitrosyl-iron complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
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        </location>
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        <location>
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            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
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        </source>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
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            <authorList>
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
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    </dbReference>
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        <location>
            <begin position="26"/>
            <end position="136"/>
        </location>
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            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="AKH86552.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="200" mass="21480" checksum="D25A28FE05DE2794" modified="2015-07-22" version="1">MSAPVMHGYFKPRILGAWRMPASGPVILAGNHSHNVDGPLLMGTSPRPVHFLIKQEAFVGIVGWYLRNIGQVAIDRTTVDRGAITRALGVLDEGGVLGIFPEGSRGEGDFSSIRAGLAYFAVRSGAPVVPVAVLGTAERRSRVVKALPPVRSHVDIVFGEPFQAGSPDGRRTRKAMDEATLRIQDRLTAHLAAARRDTGR</sequence>
</entry>
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    <accession>A0A0F7NIP7</accession>
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        <lineage>
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                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
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        <property type="entry name" value="GDHRDH"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH87158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="250" mass="25690" checksum="A505032E90E3DC5D" modified="2015-07-22" version="1">MLLKEKNALVYGAGGIGRAVALGFAREGATVHLASRTPARLEAVAADVREAGGKVSTAAVDALDESAVDAHADAVAKEAGSVDVSINLVSVGDIQGTPLAEMTLSDFEAPVRNAVRTTFLTSKAAARHMIRQKSGVLLTFGGVGDPMHDYFIGGFQVALSAVDMLRKQFAAELGPHGVRVVGLKTGGIPESIPEGFEGRDELVASLVEPTMLGRTATYEDVGNAAAFAASDRAASITAAELNITCGAIVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NIS8</accession>
    <name>A0A0F7NIS8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="5 6">
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        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
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            <taxon>Actinobacteria</taxon>
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        </lineage>
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    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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    </dbReference>
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    </dbReference>
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        <property type="gene ID" value="AA958_31280"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_31280"/>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
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        <location>
            <begin position="56"/>
            <end position="234"/>
        </location>
    </feature>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH87168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="237" mass="25673" checksum="762CB04D8E0E2D4E" modified="2015-07-22" version="1">MKILLLFTEKGPELSVEEIAHSVGISVPSAYRFVSLLREMDMVEDNGGGTYVLSPRIFLLARSAEQAFPVSKVLRPLVERLSKDTGEAALVIRRVGDFATCVEMSQPEHTIRLSFEPGQIMSLHRGAGPKVLLAAMGEAWAQRYFDRLRPAPSAAERDAVLAEVQGVAAQGWSKSEAEVDEGVWAVAAPIGVGEKVVAAVTVAGPHFRIDDERAGHITERVVAAAAELSDSLSTWRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NJ86</accession>
    <name>A0A0F7NJ86_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Arsenic resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_17135</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.</text>
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        </location>
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            <end position="51"/>
        </location>
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            <end position="86"/>
        </location>
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            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
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        </source>
    </evidence>
    <sequence length="318" mass="33186" checksum="2285CBD37497A862" modified="2015-07-22" version="1">MERHQVPVYLGALVAGGVVGWAAPGAGPGLEHAINPVLAALLYVTFLQVPAARLLRSLRAGRFLAAALVVNFAVVPLVVAAMFAFLPDEQAIRMGVLLVLLTPCVDYVIVFSGLAGGSSRRLLAATPLLLIAQMVFLPGYLYLFMGSDLADIVEAGPFVEAFVVLIAVPLTLAWLTQAWAARRPAGQKTAGAAGTAMVPLMAATLATVVASQVPKVDDSVGDVARVVPFYVLFLAVMAFAGLGVARLFRLDVPAGRAIVFTGATRNSLVVLPLALALPDRLAAAAVVIVTQTLVEVVGMVIYVRLVPRLLPSAPHGMP</sequence>
</entry>
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            <authorList>
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="AKH87027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="195" mass="21730" checksum="3C6B64AA04621951" modified="2015-07-22" version="1">MRAAYGLAVPAAAVADWEKGHARPTRVELDALAGALWCTPADLMDSPTSLHAHRRAHGLPLDDVARHIGMDPATYLSAERTGRWPGTESQATRLAHLLRLPLPDLLDLTGRSEPLARHLRDAATTRWQPQVRPVARLTRLPRRPLERALSTLHEEYQTRSAAARNWGEDPPPESAAGVTTYLQQVLPRFWELLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
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        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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            <end position="45"/>
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            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH87102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="193" mass="20515" checksum="2351B963D0DEFF93" modified="2015-07-22" version="1">MPQRRAARSTDGTGAAAAATTTPAVGYVLAGVRLMTGFVFLWAFLDKTFGFSYATPGNGAWIDGGSPTEGFLGSVAVGPMEDTFHSWAGDAWADWLFMLGLLGIGIALVLGVALRFAALATTVMMALMWVAEWPPAKHLSDGSPSMSTNPLIDYHVIYAVVAIALAVTYAGNTWGLGRMWATLPFVRDHRSLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NK11</accession>
    <name>A0A0F7NK11_9ACTN</name>
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        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
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        <lineage>
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            <taxon>Actinobacteria</taxon>
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        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Albersmeier A."/>
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                <person name="Winkler A."/>
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                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_29810"/>
    <dbReference type="EnsemblBacteria" id="AKH87127">
        <property type="protein sequence ID" value="AKH87127"/>
        <property type="gene ID" value="AA958_29810"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_29810"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6293"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF01547">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519583" evidence="1">
        <location>
            <begin position="23"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH87127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="438" mass="46894" checksum="B69A1E251E56EB29" modified="2015-07-22" version="1">MHLSRRTLLGLAAGVPASAALAACGSSGPGKGADGGTATYWHLSGQPQEGVRTGAVERFNEANPKGQIEVTTFENDAYKTKIKTAIGAGKAPTVIWGWGGGTLRSYVEAGQVDDLTPWFDQNPEIKNRLFPSSFGAATVDGKIYAMPFESVEPIVLFYNKRVFDDVGVEPPETWDDIMALVPRFNAEGIAPFSLGGQSRWTNMMWLEFLFDRIGGPEVFQAVFDGEKDAWSHPAAIEALTKVQDLIKADGFIKGFSSITADSNADQALLYTGKAAMMLHGSWSYGIQQAEGGDFVSGGGLGFMNFPPVEGGKGDPGNSVGNPAQYLSISSKASAEQKKIAKDFFATGVLTDEEVKEWIDTGAVPIAKGSEKLLAESESAEFLQFVYGIASNAKTFGQSWDQALSPTAAETLLDNIARLFQLSISPQQFTDNLNEVIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MXQ4</accession>
    <name>A0A0F7MXQ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_01295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
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        <lineage>
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            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014390.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_01295"/>
    <dbReference type="EnsemblBacteria" id="AKH81025">
        <property type="protein sequence ID" value="AKH81025"/>
        <property type="gene ID" value="AA958_01295"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_01295"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.286"/>
    <dbReference type="OrthoDB" id="1036922at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="254"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="279"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="308"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="338"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="469" mass="49320" checksum="81F562F88929D5F6" modified="2015-07-22" version="1">MAVTFTLAQLALVRPGMGLGWDESVYVSQVSGHAPAAFFSAPRARGVSLLVAPIAAWSSSTPLLRVYLAVLSGIGLWLALRAWRGLLPAKVLALGGALFASLWVTLYYGPQAMPNYWVAIGALAGVGCFLRAQADRTRRAPVWGLAAAAALMALMRPMDAAWVGLPLLVASAVVRRWRYRRLSLALAAGLAAGAAEWVIEAYTGYGGLGRRLHDASLIQGGLSWNVAVDDQMRSQIGRTLCRPCTGEMPNPVVFAWWLVFSVLAAGGLVRAVRARRAVGATALPLGCAAAAAFPYLFLIGYAAPRFLLPAYALLAIPVAHGLVSLVRATPGGAWRAPAVALAAVTLAGHLAVQLSVLHQLVGRATEGHRDWARTAAALHTAGVRPPCVLTGDEVIAPHIPIAFAAACSSADTDGHNGNTTAAALAREAGRIPVAVLTTRGTPPPSFARDWRRIHVHRHVYAYVGPAVQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MZW5</accession>
    <name>A0A0F7MZW5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glyco_hydro_35 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_06085</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 35 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_06085"/>
    <dbReference type="EnsemblBacteria" id="AKH81845">
        <property type="protein sequence ID" value="AKH81845"/>
        <property type="gene ID" value="AA958_06085"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_06085"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1271"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031330">
        <property type="entry name" value="Gly_Hdrlase_35_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001944">
        <property type="entry name" value="Glycoside_Hdrlase_35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23421">
        <property type="entry name" value="PTHR23421"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01301">
        <property type="entry name" value="Glyco_hydro_35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00742">
        <property type="entry name" value="GLHYDRLASE35"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_35" evidence="5">
        <location>
            <begin position="2"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="89"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH81845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="124" mass="13662" checksum="6B2AA1422C9574F7" modified="2015-07-22" version="1">MRLLSGAMHYFRVHEAQWGHRLAMLRAMGLTCVEAYIPWHLHEPHPGRYEDVAAAGRFIDAAQAAGLWVIVRPGPYLCAEWENGGLPHGLTGPPGRGCAPATRSSWPPWTTGSTPRCRKSPPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MZZ9</accession>
    <name>A0A0F7MZZ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_06325</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015238.1">
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_06325"/>
    <dbReference type="EnsemblBacteria" id="AKH81885">
        <property type="protein sequence ID" value="AKH81885"/>
        <property type="gene ID" value="AA958_06325"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_06325"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1321"/>
    <dbReference type="OrthoDB" id="796211at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023932">
        <property type="entry name" value="Uncharacterised_CE1759"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04037">
        <property type="entry name" value="LLM_duo_CE1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN_red" evidence="2">
        <location>
            <begin position="5"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH81885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="216" mass="22461" checksum="DDBF4E79585DDF37" modified="2015-07-22" version="1">MTALKLTVVSAGLSVPSSTRLLADRLAEAVRRQPADDGRQVEVQVVELRDLAADIAHNTVTGFPSAALAKAIDAVTGADGLIAVTPVFSGSYSGLFKSFFDVIGAADDGALAGKPVLVAATGGTARHSLVLEHAMRPLFAYLRSVVIPTAVYAAADDWGGSGDPLTDTLPTRIARAAGELAELMHGRQPRPAAGGPEQVVPFEQQLAALRPETRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0Q2</accession>
    <name>A0A0F7N0Q2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">3-oxoacyl-ACP synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_00700</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH80929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014295.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_00700"/>
    <dbReference type="EnsemblBacteria" id="AKH80929">
        <property type="protein sequence ID" value="AKH80929"/>
        <property type="gene ID" value="AA958_00700"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_00700"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.160"/>
    <dbReference type="OrthoDB" id="872193at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013751">
        <property type="entry name" value="ACP_syn_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013747">
        <property type="entry name" value="ACP_syn_III_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08545">
        <property type="entry name" value="ACP_syn_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08541">
        <property type="entry name" value="ACP_syn_III_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACP_syn_III" evidence="3">
        <location>
            <begin position="124"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="ACP_syn_III_C" evidence="2">
        <location>
            <begin position="260"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH80929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="346" mass="36213" checksum="E4B592DC4A481E57" modified="2015-07-22" version="1">MLVLNRESGLRVAGLGTASPGPPIDNATLGRRMGLGPMWEQWAEAFVGTKYRHLAVDLETGEPRFSLADLGETAGRRALAAAGLEPSDVDVVVMGTAMPDMLMPTTVNVVADRLGIDQVPTYQLQSGCSGAVQALSVAAGLLLSGSHRTALVLGGDVSAKLVDPDMDAAALPPAQLVNLMLFGDGAGALVLTAEPSPGPALRAVFTKLVGLGKQPGQTLDWYGASRRFDGPPVSEDYKAIEAAVPEMAAESAEELLNGLDWKPDELAYVLPPQLSGRMTAKIRERMGAPEAQEVSCVDETGNNGNALVFFQLERLLPKLAAGDRALGVAIESSKWIKSGFALEATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0S8</accession>
    <name>A0A0F7N0S8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_01175</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014373.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH81008">
        <property type="protein sequence ID" value="AKH81008"/>
        <property type="gene ID" value="AA958_01175"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_01175"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.259"/>
    <dbReference type="OrthoDB" id="1814691at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027961">
        <property type="entry name" value="DUF4442"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14539">
        <property type="entry name" value="DUF4442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH81008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="150" mass="16076" checksum="8CCDD324DE9DB0A2" modified="2015-07-22" version="1">MSDTMPPLGELLQASVPMVRTLGLIYDEITPEAATLRFPDRPEYRNHVGGPHAGAMFTLAESATGAVVLAAFGDQMERAVPLPVRAEIDFLKVARGDVTAKARLGRPIAEVVAELDAGKRPEFPVGVDIVRGDGAVSGRMTVLWTLRPND</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0U0</accession>
    <name>A0A0F7N0U0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AA958_00965</name>
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        </lineage>
    </organism>
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        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="12 13">CNQ-509</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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            <end position="202"/>
        </location>
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            <end position="283"/>
        </location>
    </feature>
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        <location>
            <begin position="286"/>
            <end position="342"/>
        </location>
    </feature>
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            <end position="464"/>
        </location>
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        </source>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
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</entry>
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    <accession>A0A0F7N0V4</accession>
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        </submittedName>
    </protein>
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    </gene>
    <organism evidence="7 8">
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        <lineage>
            <taxon>Bacteria</taxon>
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        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <end position="72"/>
        </location>
    </feature>
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            <end position="135"/>
        </location>
    </feature>
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        </location>
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        </location>
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        </location>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH81033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="331" mass="35970" checksum="DC98C232D70B4303" modified="2015-07-22" version="1">MTSATAKPGVAERPASPAVGPAGDGGQAPPSRASLRRDRLSRHNLSGWLFSTPFLAFFFTFMAFPIVATLLMSFTDFGLRNVTDPLSADFTGLENYSKLFGDEKFVRALLNTGYFVVLGVPLTIGSGLVAAVLLNSGIDRLRTFFRVGFYAPVVTAIVAVAVVWRFVLDPTEGLIAGLAAQVGLTAPDFLASETLAMPSLIVMAVWRNMGTAMVLFLAGLQSIPTEVREAARIDGAGAFQEFRRITLPLLRPTMLYVAIMTSIGFLNVFEEPFVMTNGGPSDSTLTVSLYMYREGFNFFHMGYASAMAYTLFVIILAVTLLQLRLLKDRTK</sequence>
</entry>
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    <name>A0A0F7N1A0_9ACTN</name>
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                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF402" evidence="1">
        <location>
            <begin position="57"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="162" mass="18364" checksum="6B02ACA3829876F5" modified="2015-07-22" version="1">MLTPGREVEVTLVKQLRPGLSYPAVVIRDDGNHAVVRAPWAGPKERDAGYVRFEQGDVWTEHFWRDRWYSVKEIQAADGRIKGWYCDVARPARVEEDRVTVHDLELDLWLSGDRQTLLRLDEDEFVASGLPERDPGTAARARAALDELEELARAGLDELLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N1M8</accession>
    <name>A0A0F7N1M8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AA958_06445</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="1"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015259.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_06445"/>
    <dbReference type="EnsemblBacteria" id="AKH81906">
        <property type="protein sequence ID" value="AKH81906"/>
        <property type="gene ID" value="AA958_06445"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_06445"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1346"/>
    <dbReference type="OrthoDB" id="561611at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011708">
        <property type="entry name" value="DNA_pol3_alpha_NTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041931">
        <property type="entry name" value="DNA_pol3_alpha_thumb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040982">
        <property type="entry name" value="DNA_pol3_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029460">
        <property type="entry name" value="DNAPol_HHH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004805">
        <property type="entry name" value="PolC_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32294">
        <property type="entry name" value="PTHR32294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07733">
        <property type="entry name" value="DNA_pol3_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17657">
        <property type="entry name" value="DNA_pol3_finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14579">
        <property type="entry name" value="HHH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00594">
        <property type="entry name" value="polc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="POLIIIAc" evidence="8">
        <location>
            <begin position="7"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH81906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="1180" mass="130733" checksum="42E1F4F43C8504B7" modified="2015-07-22" version="1">MAKPPFTHLHVHTQYSLLDGAARLKDMFAACREMGMSHIAMTDHGNLHGAYDFFVQASAAGVTPIIGIEAYVAPESRRNKRKVQWGQPHQKRDDVSGSGGYTHKTIWASSRTGLHNLFRLSSDAYKEGWLQKWPRMDKEVIAEHAEGLIASTGCPSGEVQTRLRLGQFDEALAAAAWYQEVFGKQRYFLELMDHGIEIERRVRDGLLEIGRKLGIPPLVTNDSHYTYAQEAGAHDALLCIQTGKNLSDPDRFRFDGTGYYLKSTEEMYAVDSSDAWQEGCANTLLVAEQIDTSGWFEKRDLMPRFEVPDGYSEVTWFQEEVRRGMARRYPGGVPEDRQRQAEYEMDVIIQMGFPGYFLVVADFIMWAKNNGIAVGPGRGSAAGSIVSYAMGITDLDPIEHGLIFERFLNPERVSMPDVDIDFDERRRAEVIRYVTEKYGADKVAMIGTYGTIKAKNAIKDSARVLGYPYAMGDRITKAMPADVLGKGIPLSGITDPDHPRYSEAGEVRGLYENEPDVKKVIDTARGVEGLVRQMGVHAAGVIMSSEPIVDHVPVWVRHTDQVTITQWDYPTCESLGLLKMDFLGLRNLTIMDDAVKMVKQNKGRDIELLSLPLDDPRTFELLGRGDTLGVFQFDGGPMRSLLRMMKPDNFEDISAVSALYRPGPMGMNSHINYALRKNGQQEITPIHPELEEPLKEVLDITYGLIVYQEQVQKAAQVLAGYSLGQADLLRRAMGKKKKEVLDAEFVNFQKGAREKGYSDQAIQAVWDVLVPFAGYAFNKAHSSAYGLVSYWTAYLKANYPAEYMAALLTSVRDDKDKSAVYLNECRKMGIKVLPPDVNESDANFTPRGDDTIVFGLTAVRNVGQNVVESIVRNRKAKGRYASFPDFLDKVDAVVCNKRTVESLIKAGAFDALGHTRKGLTAQYEPMIDNVVSVKRKEAEGQFDLFGGMGDEAAADEPGFGLDVQFTDEEWEKSYLLAQEREMLGLYVSDHPLFGIEHVLGDRADASIAALNGGDHADGAIVTIGGIISGLQRKMTKQGNAWAIATVEDLGGSLDCMFFPATYQLVSTQLVEDAIVFVKGRLDKREDVPRLVAMELAVPDLSEVSANAPVTITIPTVKVTPPLVEKLGEVLTQHRGGTEVRVKLQGSRTTTVLRLDRHRVTSDPALFGDLKALLGPSCLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N1U4</accession>
    <name>A0A0F7N1U4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein translocase subunit SecD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">secD</name>
        <name evidence="11" type="ORF">AA958_03280</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the SecD/SecF family. SecD subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014723.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_03280"/>
    <dbReference type="EnsemblBacteria" id="AKH81364">
        <property type="protein sequence ID" value="AKH81364"/>
        <property type="gene ID" value="AA958_03280"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_03280"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.698"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015450">
        <property type="term" value="F:protein-transporting ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043952">
        <property type="term" value="P:protein transport by the Sec complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01463_B">
        <property type="entry name" value="SecD_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005791">
        <property type="entry name" value="SecD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022813">
        <property type="entry name" value="SecD/SecF_arch_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022645">
        <property type="entry name" value="SecD/SecF_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022646">
        <property type="entry name" value="SecD/SecF_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30081">
        <property type="entry name" value="PTHR30081"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07549">
        <property type="entry name" value="Sec_GG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02355">
        <property type="entry name" value="SecD_SecF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00916">
        <property type="entry name" value="2A0604s01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01129">
        <property type="entry name" value="secD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="395"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="422"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="448"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="501"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="526"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="137"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="569"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="147"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AKH81364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="593" mass="62180" checksum="862AC84E2A1C0274" modified="2015-07-22" version="1">MAAPKTGRRSQGSHGRPWRPLLLILTAIAALTGGMFLSGHTTPRLGIDLAGGTSITLEAKPQPGGENAINSTNMETAVNIIERRVNGLGVQEAEVQTQGDRHIIVNIPKGTDQKTAREQVGTTARLFFRPVLSYEVNEAPKPSPSASESGDKDKDADKEKDASSSPSPSESASDEASDGASPSDGATEQGRALSEGLAQADDSPSPTESQAPPAETPPAEQAPTGQVPADVQKKLDALDCSDAEERTKIGENAKPTDTVVACDSEGAYKYALGPAEVEGTDVDDASATYDAQQGSGWIVQLEFNGKGSDKFADVTGTLAGQAPPNNQFAIELDGEVVSAPSVDESITGGRAQISGSFNQESAEELANVLSYGALPLSFEESEVTTVSPALGNEQLQAGLIAGAIGLGLVIIYLVAYYRGLALVAVVSLMVSAALTYTIMALLGPGIGFALNLPAVCGAIVAIGITADSFIVYFERIRDEIREGRTLRPAVERGWPRARRTILVSDFVSFLAAAVLFAVTVGKVQGFAFTLGLTTLLDVVVVFLFTKPVMTILARKRFFASGHPWSGLDPKRLGARPPLRGRPRTAGPVNPKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N1W8</accession>
    <name>A0A0F7N1W8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">rRNA methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_03485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014757.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_03485"/>
    <dbReference type="EnsemblBacteria" id="AKH81399">
        <property type="protein sequence ID" value="AKH81399"/>
        <property type="gene ID" value="AA958_03485"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_03485"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.736"/>
    <dbReference type="OrthoDB" id="1422015at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="SSF55315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SpoU_methylase" evidence="1">
        <location>
            <begin position="121"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="272" mass="28903" checksum="8C25AAF9E673B3BA" modified="2015-07-22" version="1">MAELLTVDDPADPRLSDYASLTDVELRRRREPAEGLFIAEGEKVIRRAIGTGYETRSMMLSAKWVDAMRDVIDALPAPVYVVDPGLAEQVTGYHVHRGALAAMRRKPLPGAAALLARARRVAVLETVNDHTNVGAVFRSAAALGMDAVLLSPDCADPLYRRSVKVSMGAVFHVPYARLSSWPQDLETVREAGFTLVALTPDPRAVPITEAAPGRLPRAALMLGTEGAGLSARALRAADQRVRIPMSNGVDSLNVGAAAAVAFYAVATAPAGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N1Y0</accession>
    <name>A0A0F7N1Y0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">Quinolinate synthase</fullName>
            <ecNumber evidence="2 9">2.5.1.72</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">nadA</name>
        <name evidence="10" type="ORF">AA958_06890</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>dihydroxyacetone phosphate + iminosuccinate = H(+) + 2 H2O + phosphate + quinolinate</text>
            <dbReference type="Rhea" id="RHEA:25888"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29959"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
            <dbReference type="EC" id="2.5.1.72"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="9">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from iminoaspartate: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the quinolinate synthase family. Type 3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.72" evidence="2 9"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015337.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_06890"/>
    <dbReference type="EnsemblBacteria" id="AKH81986">
        <property type="protein sequence ID" value="AKH81986"/>
        <property type="gene ID" value="AA958_06890"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_06890"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1440"/>
    <dbReference type="OrthoDB" id="613347at2"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00327"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008987">
        <property type="term" value="F:quinolinate synthetase A activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10800">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00569">
        <property type="entry name" value="NadA_type3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003473">
        <property type="entry name" value="NadA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036094">
        <property type="entry name" value="NadA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023515">
        <property type="entry name" value="Quinolinate_synth_A_type3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30573">
        <property type="entry name" value="PTHR30573"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02445">
        <property type="entry name" value="NadA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142754">
        <property type="entry name" value="SSF142754"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00550">
        <property type="entry name" value="nadA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0408">Iron</keyword>
    <keyword evidence="8 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Iminoaspartate binding" evidence="9">
        <location>
            <begin position="161"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Iminoaspartate binding" evidence="9">
        <location>
            <begin position="282"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>iminosuccinate</name>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>iminosuccinate</name>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>iminosuccinate</name>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>iminosuccinate</name>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="346"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AKH81986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="394" mass="42703" checksum="B225DC04FD44F8BC" modified="2015-07-22" version="1">MTTAQDLDVTPTPLALLLLGREADPSSERGVDCPGDLPAPSDPGLVERARAAKERLGEKVFVLGHHYQRDEVIQFADVTGDSFKLAQQAAARPEAEYIVFCGVHFMAESADILTSDSQAVVLPDLAAGCSMADMATAEQVAECWDVLTEAGVADVTVPVSYMNSSADIKAFTGRHGGTICTSSNAERALNWAFDQRPAGAGKVLFLPDQHLGRNTAIRDLGLSPDDCVVYNPHRPNGGLTAEQLRAAKMILWRGHCSVHGRFSLDSVKEVRERIPGVNVLVHPECKHEVVAAADQVGSTEHIIKALDAAPAGSKWAVGTELNLVRRLAKQHPDKEIVFLDRTVCFCSTMNRIDLPHLVWALESLADGKLVNRIEVDEETEDHAKLALERMLALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N249</accession>
    <name>A0A0F7N249_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_03810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014816.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_03810"/>
    <dbReference type="EnsemblBacteria" id="AKH81459">
        <property type="protein sequence ID" value="AKH81459"/>
        <property type="gene ID" value="AA958_03810"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_03810"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.801"/>
    <dbReference type="OrthoDB" id="1782537at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014995">
        <property type="entry name" value="DUF1844"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08899">
        <property type="entry name" value="DUF1844"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="121" mass="12277" checksum="A63763F47C2BCA29" modified="2015-07-22" version="1">MSDTGPGADAGPDFDALTRDIAEVPAVEVITTVAVHLMSAAAVKLGLAEDGAAHKDLDEARKLITALAGLVTAGAAEVGSYHAAPLRDGLKSLQLAFREASEHPDEPGQGPGEAYTGPVFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2B0</accession>
    <name>A0A0F7N2B0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chaplin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_04185</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014879.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_04185"/>
    <dbReference type="EnsemblBacteria" id="AKH81524">
        <property type="protein sequence ID" value="AKH81524"/>
        <property type="gene ID" value="AA958_04185"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_04185"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.878"/>
    <dbReference type="OrthoDB" id="2037979at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005528">
        <property type="entry name" value="ChpA-H"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03777">
        <property type="entry name" value="ChpA-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51884">
        <property type="entry name" value="CHAPLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0034">Amyloid</keyword>
    <keyword evidence="2" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519173" evidence="5">
        <location>
            <begin position="26"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Chaplin" evidence="6">
        <location>
            <begin position="36"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH81524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="77" mass="7264" checksum="C6C5D82C25494CA3" modified="2015-07-22" version="1">MIKKVVAAAAATGGLMLAGAGVAAADAGAQGAAVQSPGVLSGNVVQAPIHIPVNACGNTVNVVGLLNPAFGNTCINK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2I4</accession>
    <name>A0A0F7N2I4_9ACTN</name>
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        <submittedName>
            <fullName evidence="4">PTS glucose transporter subunit IIA</fullName>
        </submittedName>
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    <gene>
        <name evidence="4" type="ORF">AA958_01585</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
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            <taxon>Actinobacteria</taxon>
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            <authorList>
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                <person name="Albersmeier A."/>
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                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
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        <property type="gene ID" value="AA958_01585"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_01585"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="20"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH81072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="149" mass="15215" checksum="5F6AD4D07C8EC86A" modified="2015-07-22" version="1">MTQVSSPLTGRAIGLAAVPDPVFSGGMVGPGTAVDPERGTSEAVAPIGGLVLSLRPHVFVVVDDEGHGVLIHLGIDTVQLNGEGFELLVAKGDRVERGQPVVRWDTVAVEEAGKSPISPVVALEAAEGALSAVAEDGEIKAGETLFTWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2M4</accession>
    <name>A0A0F7N2M4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="2 3">
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        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
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        <property type="gene ID" value="AA958_04885"/>
    </dbReference>
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    <dbReference type="PATRIC" id="fig|444103.5.peg.1028"/>
    <dbReference type="OrthoDB" id="2029783at2"/>
    <dbReference type="Proteomes" id="UP000034283">
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    </dbReference>
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        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="75" mass="8537" checksum="1A28CBEA4FF3AA4B" modified="2015-07-22" version="1">MRPAHEPHAAARPSGTPIYDALFAEYRRLFRALPGDRSGEEQLRFDAIMNSRPSLPSTGRLRPHVHVHRHRAADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2W7</accession>
    <name>A0A0F7N2W7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">IclR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_05415</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_05415"/>
    <dbReference type="EnsemblBacteria" id="AKH81728">
        <property type="protein sequence ID" value="AKH81728"/>
        <property type="gene ID" value="AA958_05415"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_05415"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1135"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
            <begin position="12"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="4">
        <location>
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            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH81728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="257" mass="28180" checksum="C22639F987B44207" modified="2015-07-22" version="1">MGVADAGGGGQVKSAVRTVELLEYFAARPGMHSLGDVQHAVGYPKSSLYMLLRTLTELGWVETDATGTRYGIGVRALLVGTSYIDGDEVVAAARPTLDRLADDTTETIHLARLDGVNIVYLATRQSQHYLRPFTRVGRRLPAHATALGKALLATYPDEEIRKLLPESLAPLTEHTVTDRERLIEELHRVRERGYALDREESTLGLRCVGVAVPYRAPARDAISCSVPVARLTPAHEQGIRDALLDARDRLTLATRHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N325</accession>
    <name>A0A0F7N325_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Tellurium resistance protein TerC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_05765</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TerC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015142.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_05765"/>
    <dbReference type="EnsemblBacteria" id="AKH81789">
        <property type="protein sequence ID" value="AKH81789"/>
        <property type="gene ID" value="AA958_05765"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_05765"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1207"/>
    <dbReference type="OrthoDB" id="1917125at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005496">
        <property type="entry name" value="Integral_membrane_TerC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022369">
        <property type="entry name" value="Integral_membrane_TerC_rswitch"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30238:SF0">
        <property type="entry name" value="PTHR30238:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03741">
        <property type="entry name" value="TerC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03718">
        <property type="entry name" value="R_switched_Alx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="288"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="311"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH81789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="335" mass="36660" checksum="00AD723D4328C895" modified="2015-07-22" version="1">MDVSLTLWVLTIVGLCALIGTDFLVGRKPHEVTLKEAGTWTIIWIVLAGLFGVGLLIWGDGQASGEFFAGYVTEKSLSVDNLFIFVIIMSKFAVPPQYQARVLMVGVLIALVMRAAFIAAGAALIASFSWVFYIFGAFLIYTAWKLIQEATADEEEEWEENRLLKAVERRFAATDKYHGTKLFITENGKRLMTPMLIVMLAIGTTDLLFALDSIPAIFGLTQDPYIVFTANAFALMGLRQLYFLIGGLLKKLVHLSYGLSAILGFIGVKLVLHALHESGVHVPEISTAISLSVIGGVLVITTITSLRASRRLEAEQKDKEEEPAEAGHHPGKGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N389</accession>
    <name>A0A0F7N389_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">rRNA cytosine-C5-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_03055</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014685.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_03055"/>
    <dbReference type="EnsemblBacteria" id="AKH81322">
        <property type="protein sequence ID" value="AKH81322"/>
        <property type="gene ID" value="AA958_03055"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_03055"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.651"/>
    <dbReference type="OrthoDB" id="1064993at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001510">
        <property type="term" value="P:RNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.940.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018314">
        <property type="entry name" value="Fmu/NOL1/Nop2p_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB/NOP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035926">
        <property type="entry name" value="NusB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006027">
        <property type="entry name" value="NusB_RsmB_TIM44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807">
        <property type="entry name" value="PTHR22807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01029">
        <property type="entry name" value="NusB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48013">
        <property type="entry name" value="SSF48013"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01153">
        <property type="entry name" value="NOL1_NOP2_SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM_MT_RSMB_NOP" evidence="7">
        <location>
            <begin position="184"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="6">
        <location>
            <begin position="286"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="407"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="337"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="354"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH81322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="472" mass="50797" checksum="D974CF88F2C79F19" modified="2015-07-22" version="1">MSDQPRRRRPAKPYRRPQKDPVRILAYDALRAVDERDAYANLVLPPMLRQARQRDGFDARDAALATELVYGTLRRQGTYDRIIAACVDRPLREVDPEVLDVLSLGAHQLLGTRIPPHAAVSATVELARVVLGDGRARFVNAVLRKIAARDLDGWLAEVAPPYADDPEEHLAVVHSHPRWIVSALWDALGGGRAGMEELLTADNERPEVTLVARPGRATPAELSGPDTLPGRWSPYAVRLAEGGDPGALDEVRDGRAGVQDEGSQLVALALANAPLEGPDTRWLDGCAGPGGKAALLGALAAERGAALVAAEKQPHRARLVARALAGNPGPYQVVVADGTRPAWRPGGFDRVLVDVPCTGLGALRRRPEARWRRRPEDLEGFAPLQRALLEDALRAVRTGGVVGYVTCSPHPAETRAVVDDVLKAAGAPAAELVDARPLLPGVPELGEGPDIQLWPHRHGTDAMYLALLRRTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3D0</accession>
    <name>A0A0F7N3D0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chloramphenicol phosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_06275</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015232.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_06275"/>
    <dbReference type="EnsemblBacteria" id="AKH81879">
        <property type="protein sequence ID" value="AKH81879"/>
        <property type="gene ID" value="AA958_06275"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_06275"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1312"/>
    <dbReference type="OrthoDB" id="1869017at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012853">
        <property type="entry name" value="CPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007531">
        <property type="entry name" value="CPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="active site" evidence="1">
        <location>
            <position position="39"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="11"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR007531-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR007531-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH81879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="192" mass="21368" checksum="A3208FF78BCE07C4" modified="2015-07-22" version="1">MASGRIIFLNGTSSSGKSSIAKELLGILDDGVYFHMAVDGFNAMRTKRELGADELDAALRRTRMGFHRSIAAMAEAGNDIVVDHVLSEPWRLLDCLTLLPAEDVLFVGVYCPLDELTRRERARGDRPPGLAAHQYDLVHSHGDYDFECDTSAASPRECAQRIKEFLPHRPTPTAFTRLRRHHLADGREPLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3I0</accession>
    <name>A0A0F7N3I0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_10615</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015942.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_10615"/>
    <dbReference type="EnsemblBacteria" id="AKH82601">
        <property type="protein sequence ID" value="AKH82601"/>
        <property type="gene ID" value="AA958_10615"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_10615"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2232"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="2">
        <location>
            <begin position="9"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="3">
        <location>
            <begin position="144"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH82601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="365" mass="38133" checksum="ADE93BB5A96E2EFB" modified="2015-07-22" version="1">MDGTPGTPLRVGLLGYGLAGSVFHAPLVAATDGLVLDTVVTGDPERQKQVRAAYPDATTVATADDLLARADRLDLAVVASPNRTHVPLATAALEAGLPVVVDKPLAATAAEAEELATLADARGLLLSAFHNRRWDNDFRTLAALLADGSLGDVHRFESRFERWRPALRGGWRDSADPADVGGLLYDLGSHLVDQALTLFGPVTSVYAESDARRAGSVVDDDDFVALAHAGGVRTHLWMTAMAPQLGPRFRVLGSRAGYVKYGLDPQEAALRDGRRPGDGDGTWGAEPESAWGRLGAGESPLTGGGEPVPTLPGAYPAYYAGIVEALRTGTPPPVTAAEAAATLRVLEAARRSAAEGRVVRLADGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3S1</accession>
    <name>A0A0F7N3S1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Adenosylcobinamide kinase</fullName>
            <ecNumber evidence="8">2.7.1.156</ecNumber>
            <ecNumber evidence="9">2.7.7.62</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Adenosylcobinamide-phosphate guanylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">AA958_06930</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenosylcob(III)inamide + ATP = adenosylcob(III)inamide phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15769"/>
            <dbReference type="ChEBI" id="CHEBI:2480"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58502"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.156"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>adenosylcob(III)inamide + GTP = adenosylcob(III)inamide phosphate + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15765"/>
            <dbReference type="ChEBI" id="CHEBI:2480"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58502"/>
            <dbReference type="EC" id="2.7.1.156"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>adenosylcob(III)inamide phosphate + GTP + H(+) = adenosylcob(III)inamide-GDP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22712"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58502"/>
            <dbReference type="ChEBI" id="CHEBI:60487"/>
            <dbReference type="EC" id="2.7.7.62"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 5/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 6/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the CobU/CobP family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.156" evidence="8"/>
    <dbReference type="EC" id="2.7.7.62" evidence="9"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015344.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_06930"/>
    <dbReference type="EnsemblBacteria" id="AKH81993">
        <property type="protein sequence ID" value="AKH81993"/>
        <property type="gene ID" value="AA958_06930"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_06930"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1448"/>
    <dbReference type="OrthoDB" id="1765140at2"/>
    <dbReference type="UniPathway" id="UPA00148">
        <property type="reaction ID" value="UER00236"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043752">
        <property type="term" value="F:adenosylcobinamide kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008820">
        <property type="term" value="F:cobinamide phosphate guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00544">
        <property type="entry name" value="CobU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003203">
        <property type="entry name" value="Cobinamide_kinase/P_G-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34848">
        <property type="entry name" value="PTHR34848"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02283">
        <property type="entry name" value="CobU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00003889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00005159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00007490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00012523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AKH81993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="400" mass="40475" checksum="6E0ECB905AC5927F" modified="2015-07-22" version="1">MDITLLGTGAPAGLPRPGCPCAACAAAVGPEARAATSVLVDGIVLLDLTPGTALAAARAGRTLSGVMQVLLSHPHDGPALASPAGVPAPSRAPEGQDVTLISGHRVRAVAVDHPGTGYEITGPGGRRLLYLPPGAAPAGLEGSVEPYDIVLLDVCGRPGALARLRAHGAVAPATDVVAVHLGGHSGDASGPTPPPGPELHRRLAAAGARAVPDGVSLVAGHGPDSPVVPRRTLVLGGARSGKSVEAERRLAAFPAVEYAATGGTRDGDAEWAARVAVHRERRPASWRTTETCDLVPLLAADGAPPLLIDCLSLWLTDAMDRAGAWQGGDVRPRADELVAAVRATRRTVVAVSNEVGSGVVPATPAGRLFRDELGRLNAGVAAECEQVLLVVAGQVQILRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N418</accession>
    <name>A0A0F7N418_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Homogentisate 1,2-dioxygenase</fullName>
            <shortName evidence="6">HGDO</shortName>
            <ecNumber evidence="6">1.13.11.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Homogentisate oxygenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Homogentisic acid oxidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Homogentisicase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">hmgA</name>
        <name evidence="8" type="ORF">AA958_04600</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in the catabolism of homogentisate (2,5-dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>homogentisate + O2 = 4-maleylacetoacetate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15449"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16169"/>
            <dbReference type="ChEBI" id="CHEBI:17105"/>
            <dbReference type="EC" id="1.13.11.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 4/6.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Hexamer; dimer of trimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the homogentisate dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.5" evidence="6"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014947.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_04600"/>
    <dbReference type="EnsemblBacteria" id="AKH81592">
        <property type="protein sequence ID" value="AKH81592"/>
        <property type="gene ID" value="AA958_04600"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_04600"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.970"/>
    <dbReference type="OrthoDB" id="193687at2"/>
    <dbReference type="UniPathway" id="UPA00139">
        <property type="reaction ID" value="UER00339"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004411">
        <property type="term" value="F:homogentisate 1,2-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006572">
        <property type="term" value="P:tyrosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00334">
        <property type="entry name" value="Homogentis_dioxygen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005708">
        <property type="entry name" value="Homogentis_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022950">
        <property type="entry name" value="Homogentis_dOase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11056">
        <property type="entry name" value="PTHR11056"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04209">
        <property type="entry name" value="HgmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01015">
        <property type="entry name" value="hmgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 6" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0828">Tyrosine catabolism</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="23"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="304"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="386"/>
        </location>
        <ligand>
            <name>homogentisate</name>
            <dbReference type="ChEBI" id="CHEBI:16169"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH81592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="460" mass="49987" checksum="AA6F77CE0E362464" modified="2015-07-22" version="1">MTSSAEQERAERARKTAEGLTYLSGFGNQHSSEAIPGALPTGRNSPQRAPLGLYAEQLSGSAFTEPRARNRRSWLYRIRPSAAHPRFVRADNGALRTAPFTEAVPDPNRLRWNPLPEPPPGTDFLAGLWTLGGNGDAAQRTGMAIHLYAANAPMDRVFSDADGELLVVPERGGLLLRTELGLLHAEPGHVALVPRGVRFRVEPLTAGATVRGYVCENYGSPFVLPELGPIGANGLANPRDFLAPVAAYEETEGPVEVVSKFCGNLWGATYDHSPLDVVAWHGNHVPYVYDLHRFNVIGTISYDHPDPSIFTVLTSPSDTPGLAGVDFVVFAPRWLVGEDTFRPPYFHRNVMSEYMGLVEGAYDAKTAGPGGFVPGGGSLHNMMSAHGPDQETFDRASAAELKPQKIDDGLAFMFETRWPVTLTPQARDAEHLQQGYDDVWRGLLRQAGGLGGSPRGHRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N469</accession>
    <name>A0A0F7N469_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cytidylate kinase</fullName>
            <shortName evidence="8">CK</shortName>
            <ecNumber evidence="8">2.7.4.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Cytidine monophosphate kinase</fullName>
            <shortName evidence="8">CMP kinase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cmk</name>
        <name evidence="10" type="ORF">AA958_04905</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + CMP = ADP + CDP</text>
            <dbReference type="Rhea" id="RHEA:11600"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58069"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.25"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 8">
            <text>ATP + dCMP = ADP + dCDP</text>
            <dbReference type="Rhea" id="RHEA:25094"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57566"/>
            <dbReference type="ChEBI" id="CHEBI:58593"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.25"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the cytidylate kinase family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.25" evidence="8"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014997.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_04905"/>
    <dbReference type="EnsemblBacteria" id="AKH81642">
        <property type="protein sequence ID" value="AKH81642"/>
        <property type="gene ID" value="AA958_04905"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_04905"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1032"/>
    <dbReference type="OrthoDB" id="776861at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036430">
        <property type="term" value="F:CMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036431">
        <property type="term" value="F:dCMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006220">
        <property type="term" value="P:pyrimidine nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02020">
        <property type="entry name" value="CMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00238">
        <property type="entry name" value="Cytidyl_kinase_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003136">
        <property type="entry name" value="Cytidylate_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011994">
        <property type="entry name" value="Cytidylate_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02224">
        <property type="entry name" value="Cytidylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00017">
        <property type="entry name" value="cmk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidylate_kin" evidence="9">
        <location>
            <begin position="14"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="18"/>
            <end position="26"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AKH81642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="236" mass="24344" checksum="4E47C6166B059E4A" modified="2015-07-22" version="1">MDSAARAQRAPVIVAIDGPAGTGKSSTSRAVAARLGLRYLDTGAQYRAAAWWMLTNGVDVADAAAIAAAAEKPQIVSGTDPGTPTITVDGADAAGPIRTQEVTAAVSAVSAVPEVRTRITALQRSIAAESVKSGGIVVEGRDIGTTVLPDADVKIFLTASEEVRAARRSGELKGREARDLAATQASLARRDAADSGRKVSPLAKAADATEVDTTELTLEQVIQCVVTLVEEKQQGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N488</accession>
    <name>A0A0F7N488_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-lactamase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_07995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015534.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_07995"/>
    <dbReference type="EnsemblBacteria" id="AKH82184">
        <property type="protein sequence ID" value="AKH82184"/>
        <property type="gene ID" value="AA958_07995"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_07995"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1686"/>
    <dbReference type="OrthoDB" id="1712770at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="18"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="251" mass="26360" checksum="736FE5F302EBA2C6" modified="2015-07-22" version="1">MKLTVLGGRGAWPTADAACSGYLVEHDGHRLLLDPGYAVMPQLLRHLRPGDVDAVVVTHGHPDHCADLNPLLRARALADRPWPALPVYAPAGALDAVLALDRPGMLRGSYELRAFDPATEPEFTSGPFRVQTRSLPHHVPNAGLRLTAAGRVLAYTGDTGPSPALAELAAAADLFLAEATYPEEVPEEDAPYLSSARQAGEHAARAGAERLLLTHLWPGGDEAAAIAAARRGFGGEAGVARPGTVVEFGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4M1</accession>
    <name>A0A0F7N4M1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Alpha-amylase</fullName>
            <ecNumber evidence="7">3.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AA958_08825</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>Endohydrolysis of (1-&gt;4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1-&gt;4)-alpha-linked D-glucose units.</text>
            <dbReference type="EC" id="3.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.1" evidence="7"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015661.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_08825"/>
    <dbReference type="EnsemblBacteria" id="AKH82314">
        <property type="protein sequence ID" value="AKH82314"/>
        <property type="gene ID" value="AA958_08825"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_08825"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1859"/>
    <dbReference type="OrthoDB" id="99080at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006048">
        <property type="entry name" value="A-amylase/branching_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031319">
        <property type="entry name" value="A-amylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006046">
        <property type="entry name" value="Alpha_amylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02806">
        <property type="entry name" value="Alpha-amylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00110">
        <property type="entry name" value="ALPHAAMYLASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00632">
        <property type="entry name" value="Aamy_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519182" description="Alpha-amylase" evidence="8">
        <location>
            <begin position="36"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="Aamy" evidence="10">
        <location>
            <begin position="49"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="Aamy_C" evidence="9">
        <location>
            <begin position="403"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AKH82314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="477" mass="50421" checksum="CE252E84FB1B27B0" modified="2015-07-22" version="1">MAQSVRRRRRGSRLLPGTALAALVLGLLPAATAHANTEAVARDTAAGNDVIANLWSWNWKSVAAECTDVLGPAGYGAVWVAPPAESLSHPRHHWWDVYQPYSYGLSGRFGTEADFTAMTAACNGAGVAVYTDAVVNHTAAQTGTGYAGTALGDKYAPPMYSRADYNVDVCNREISNWDDKWEVQNCELLGLPDLKTGSDSVRDKIAGYLNSQIARGVSGFRVDAAKHIPAADLEAIAGRLDDTADGSRPFVFHEVFPGGTPAPDEYYGSGRVLDFAFGDRVKAAFQSDIAQLENLGPGQGLLPAGNSVSFVTNHDTERNGRHLTYKDGDTAVLANVFQLGWTEAPPTVYAGFAFAGNDDSPPADADGFVTGTDCAAGWSCLDRDPRITGMVGWRNAAGDAEVTDWQSPRGNVVGFGRGDRGFAALNNTGEPVTQEFGTAVPDGVYCNVLDDCAGKVTVAGGRVTLDLPARGAVAFHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4P0</accession>
    <name>A0A0F7N4P0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_12820</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AfsR/DnrI/RedD regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016295.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_12820"/>
    <dbReference type="EnsemblBacteria" id="AKH82961">
        <property type="protein sequence ID" value="AKH82961"/>
        <property type="gene ID" value="AA958_12820"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_12820"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2693"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15831">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03704">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="2" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="840"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH82961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="971" mass="104765" checksum="3948F0983115095F" modified="2015-07-22" version="1">MAHEDETSALRFAVLGPVRAWRGEESLPVGAPQQRAMLAALLLRGGRTATAQELVDGIWGEEPPPRAVSALRTYASRLRRTLGADALVSEAGGYAIRAHGTEVDIATAEELARAAETAAAAGDFAKARELYAGALAQFTGEPLGGVPGPYADWHRDRLEELRLSLLEHRIELDLDAARHAEAVSELTALTAGHPLRERFRELLMLALYRSGRQAEALAVYADTRRLLQDELGVDPRPELAELQQRILQADEDLAAPKTEPLAGDAPFRVVRPAQLPATVSDFTGRVGVVEELGKELANAPDTVMAVSSVSGIGGVGKTTLAVHVAHAARESFPDGQLYADLQGSGPSPAEPAAVLGAFLRALGTPDADIPEPVDERAALYRSVLAGRRILTLLDNARDAAQIRPLLPGTEGCAALITSRTRMTDLAGAHHVDLDVMAPDEALLLFTRIVGAERVDPERDAAMDVVAACGFLPLAIRIAASRLAARRTWTVSVLARKLSDEHRRLDELRVGDLAVKATFELGYGQLEPEQARAFRLLGLADGPDISVTSAAAIVDRTAEDAEELLEDLVDASLVESAAPGRYRYHDLVRLFARDCAEREEPANEREAALSRLLDFYIATAAKAYELSRPGDTLTKHLSPLSLQGLAFESREAAHDWLFSEAACLLATVRQLAEGSTLARTVDLLLAAKDLAESGAYSLQFVRMATTVLEVAQAAADTRSQGRAHLVLTFSHVFSGRFEQANVHATHALLLTRADEDVWVGGEAANLRGFIADLQGKTGQAKEHLESALESYRADDNLEGESSALSNLSRLHLSMGFTASAIDLAEQALTVQRRMGVSFRIANIMYALGIALTEAGRYEDAFAELRKALEIFRENRMSLWDGMTLFRMAQAELAWEHPAESAALAEQALARLQGIGGDWHRAHILTDLGRALDQLGQSDRARACWSEALGLHEKAQSPDADRVRALLATASIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4Y9</accession>
    <name>A0A0F7N4Y9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Dihydrofolate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_09625</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015788.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_09625"/>
    <dbReference type="EnsemblBacteria" id="AKH82444">
        <property type="protein sequence ID" value="AKH82444"/>
        <property type="gene ID" value="AA958_09625"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_09625"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2028"/>
    <dbReference type="OrthoDB" id="1232874at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001645">
        <property type="entry name" value="Folylpolyglutamate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018109">
        <property type="entry name" value="Folylpolyglutamate_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136">
        <property type="entry name" value="PTHR11136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01499">
        <property type="entry name" value="folC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01012">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase_M" evidence="6">
        <location>
            <begin position="122"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_C" evidence="5">
        <location>
            <begin position="386"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH82444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="527" mass="55218" checksum="75E443562011F1BF" modified="2015-07-22" version="1">MSAREEPAGPDPDETPGSPDTPGGPEDDAFEEIVGTETDRDPDLAVIEAGSRTLRAQGGPPAGDGVPAVPADPEVARALREAEAELLARWPETRIDPSLERIQALLDILGEPQRAYPSIHLTGTNGKSSTARMIEALLVACDLRTGRFTSPHLQSITERIGLDGAPIDAERFVETYRELKPYAELVDARQEHPLSFFEMLTAMAFAAFAEAPVDAAVVEVGLGGTWDSTNVIDASVAVVTPIAVDHSRLLGDTPGAIAADKAGIIKKTATSPGGGTGTVVIMAQQPVDAAQVILKRAVEMDATVAREGMEFGVLSREVAVGGQLLTLRGLGGEYPEVFLPLHGEHMAHNAAVALAAVEAFFGVGSEHARSLDADTVRRAFAAVTSPGRLEIVRTSPTVILDAAHNPAGALATAAGVQEAFGFSRLVGVVGTSREKDVRGVLEAFEPIFSEVVITRNSTTRAMDPDELAAIAVEVFGSERVQVEPRLDDALEAAITLAEEEDEYAGAGVLVTGSVITAGEARLLLGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N507</accession>
    <name>A0A0F7N507_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Imidazole glycerol phosphate synthase subunit HisF</fullName>
            <ecNumber evidence="9">4.3.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">IGP synthase cyclase subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">IGP synthase subunit HisF</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">ImGP synthase subunit HisF</fullName>
            <shortName evidence="9">IGPS subunit HisF</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">hisF</name>
        <name evidence="11" type="ORF">AA958_06360</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + H(+) + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24793"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="ChEBI" id="CHEBI:58525"/>
            <dbReference type="EC" id="4.3.2.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 5/9.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 9">Heterodimer of HisH and HisF.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9 10">Belongs to the HisA/HisF family.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.10" evidence="9"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015245.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_06360"/>
    <dbReference type="EnsemblBacteria" id="AKH81892">
        <property type="protein sequence ID" value="AKH81892"/>
        <property type="gene ID" value="AA958_06360"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_06360"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1328"/>
    <dbReference type="OrthoDB" id="1522718at2"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:imidazoleglycerol-phosphate synthase activity"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="F:lyase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Aldolase_TIM"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="9">
        <location>
            <position position="12"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AKH81892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="262" mass="27519" checksum="ABB791CD2EAE0136" modified="2015-07-22" version="1">MSLAVRVIPCLDVDGGRVVKGVHFRNLRDAGDPVEMAKVYDAEGADELTFLDITASSGDRETTYEIVRRTAEQVFIPLTVGGGVRTVEDVDRLLRAGADKVGVNTAAIARPELIREIAERFGSQVLVLSADARRCGAGAATPSGFEVTTHGGRRGTGLDAVEWAERAAGLGAGEILLNSMDADGTKDGYDTEMIAAVRKRVTVPVIASGGAGRLDHFPPAIDAGADAVLAASVFHFGDLRIGEVKETLRTAGRAVRATPPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N516</accession>
    <name>A0A0F7N516_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_13635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_13635"/>
    <dbReference type="EnsemblBacteria" id="AKH83101">
        <property type="protein sequence ID" value="AKH83101"/>
        <property type="gene ID" value="AA958_13635"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_13635"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2869"/>
    <dbReference type="OrthoDB" id="1327142at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021373">
        <property type="entry name" value="DUF2993"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11209">
        <property type="entry name" value="LmeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519198" evidence="1">
        <location>
            <begin position="26"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="242" mass="25933" checksum="8976782D721CB354" modified="2015-07-22" version="1">MRALKITAVVLVVLGLLTLAADRVALKMAESDAAERIEKEYGFSQRPEIDIKGFPFLTQLMSREFEAVDVRIDGIDATGSGGRALRLDGVRGELEGVRISGDDWDRATADKADGKVTIRYEDISAALPVVKVSYGGKGAAGENKVKATVGTSFLGQRLEESLLGKVSVVDGDTIRLRATGVDNLGGVPGLEDYVRDHMNYNWTINDLPPGIRLTDVEVRKDGIVVTGSGTDVELGDERSAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N547</accession>
    <name>A0A0F7N547_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_17895</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017072.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH83770">
        <property type="protein sequence ID" value="AKH83770"/>
        <property type="gene ID" value="AA958_17895"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_17895"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3769"/>
    <dbReference type="OrthoDB" id="1384345at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="112"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="216"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="284"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="307"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="347"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="375"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="21"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH83770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="404" mass="40402" checksum="C0926393FE861B77" modified="2015-07-22" version="1">MDENPTLQKAASPLRRSLPGWLIALTLTTFTFSTDDYLVAGVLPGIADDLDVSEAAVGQLVTVFSLVLALAAPVASVLTATWPRRPLFTAALAVFAAANFAMPLVASFPVLMALRVAAALAAAIVVPGALGAAAALAPPERQGRYMGTVFAGLTTSLLLGVPLGTWVGAVAGWQGAFVLGGLLGVASLAALYATLPEPPRGEALRLADRLTPLARPALLLGLAATAVAVLGNLMVVTYLAVYLRDLAGVGPTGLGVIFVLAGAAGIAGSQLGGPAADRWGAERALLMGCGAFALVMLGLVACWPLRPAPLVLVVPLLLLWSAAAWWIPPAASARLLRLAGPAGAQALALNSSAVYLGVAAGGAVGGVLLDAYGSGALPAGAAAAQLVALALFGLASRRATQGKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5N3</accession>
    <name>A0A0F7N5N3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_11265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016051.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_11265"/>
    <dbReference type="EnsemblBacteria" id="AKH82713">
        <property type="protein sequence ID" value="AKH82713"/>
        <property type="gene ID" value="AA958_11265"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_11265"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2374"/>
    <dbReference type="OrthoDB" id="1538300at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="11"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="200" mass="22189" checksum="70ED0F71A6FCAC37" modified="2015-07-22" version="1">MEPVTLDTDRLLLRPMEAGDVDAVLAACQDPDVQRWTRVPSPYGRGHAEDFVLKIGPAGWREDTMYNFGVFTRDGGALVGSMGLVGFTPSRHAERVAELGYWTAPEQRRRGYTAEAVAAVVRWAFTEVGIDRVEWFAEVGNEPSRAVALRAGFTMEGTLRSWFVNHGTRRDAWVGSLLPSDLGLESRLPYLPAQPQQSPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-08-12" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5Q9</accession>
    <name>A0A0F7N5Q9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LytR family regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_11465</name>
    </gene>
    <organism evidence="5 6">
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            <taxon>Streptomycetaceae</taxon>
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        </lineage>
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        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        <property type="gene ID" value="AA958_11465"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="125"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="LytR_cpsA_psr" evidence="4">
        <location>
            <begin position="210"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="49"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH82748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="457" mass="48571" checksum="05BA2CA6CF8AAC44" modified="2015-07-22" version="1">MGIVARQHLDGTGSGTDEPGTPRAREPEAPYAGDTSTAAHAAYVDAAFAPGAQGTPGAPGALGGRPGGPDGRDPLADPVTSPATGPAADPATGPGGPDDPDGPEDPAGAPSHAAPRRRMRRGRKVLLGAVIMLFAGVLMVAGGLWWAYEHYTGRVDRIPNAFPTNVPEKHRPAPSKGGETYLLIGVDARSDLPLTGDGAGEHTWKPGAQRSDTMMLVHLPEGRDGGYVVSLPRDSWVNIPGRGDAKLNAAFSYGGPPLLIDTVQRMTKVKIDHLAVIDWSGFKRLTDAVGGVDITIDETTPRRNGGGEWTAGTHHMDGKTALDYVRERHGLPRGDLDRTQRQQNFLRAVITETMSSDNFSNPLKVKRLLDAVTATVSVDDRFSDGAMRDLMWDMKGVRSGDLVFMNAPVAGLDMIEGQSVVLLDDKAGDPLWEAMRNDTMAQYVEKYPTDRLGGTAP</sequence>
</entry>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">CNQ-509</strain>
        </source>
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    </dbReference>
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            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="65" mass="6616" checksum="06DC321794439209" modified="2015-07-22" version="1">MVPIRSGGYEPPRSLPSAFSTVNSTQNGVMSASPFSPSAAPKAALSTSDTPVTVIPMWPVAPALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5W6</accession>
    <name>A0A0F7N5W6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_11985</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
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    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AKH82833">
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    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_11985"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
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            <end position="102"/>
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            <end position="134"/>
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    </feature>
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            <end position="172"/>
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            <end position="276"/>
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        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH82833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="522" mass="52391" checksum="E16FBC5DFFFBDDDD" modified="2015-07-22" version="1">MTASGEAVSEVSGGRRPVWWWARRRSMVLDVVLAAASAAECVAQGVPFARDAGLPLGFGIVLGLVAGSTLVLRRRWPIVPVLVGMAVTPAEMGFLLAVVGLYTLAASDIPRRITAALAGMSVSAVIIVTFVQMYQTFEEHDRDSPFVLAALVALLMSVGVTLPPLLFGLYVGARRRLVESLRERADGLERELSLLAERAEERAVWARREERTRIARDMHDVVAHRVSLMVVHAAALERVVLNDPEKAARNAALVGDMGRQALTELREMLGVLRMPAGSVSSPGSGAPGGGEAVVGAAAPGGAASGAAASGCTAAEAAGAGVAVAGAGADGADGAGVAGGGPEAASSAAGGAPAAVATDAGRPARGGPAAAGAAAARAGQRPRGAADADAGGPGPRLDDLEALIGESRAAGMAVDFAEEGDPGPYAAEVEQTVYRVVQEALTNVHKHAPGAKTRVLLAHRVAEVAVLVVNGPSDAASQSAGLPSGGNGLVGMRERVTGLGGGFVSAATDAGGFRVSAVLPSGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N641</accession>
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        <recommendedName>
            <fullName evidence="3">FHA domain-containing protein</fullName>
        </recommendedName>
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    </gene>
    <organism evidence="4 5">
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        <lineage>
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    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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    <dbReference type="STRING" id="444103.AA958_16360"/>
    <dbReference type="EnsemblBacteria" id="AKH83521">
        <property type="protein sequence ID" value="AKH83521"/>
        <property type="gene ID" value="AA958_16360"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <location>
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            <end position="145"/>
        </location>
    </feature>
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            <end position="74"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH83521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="168" mass="18331" checksum="B3DDFCC6F8C0894E" modified="2015-07-22" version="1">MSELTLTVMRLGFLAVLWLFVIVAVQVIRSDLFGTRVTRRAAAAQDRPPPRPQAPPQDARGGRGGRRGQRGAPTKLVVTEGSLTGTTVTLQGQTITLGRAHDSTIVLDDDYASSRHARIYPDRDGRWIVEDLGSTNGTYLDRTRLTVPVPIPPGAPIRIGKTVIELRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N673</accession>
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        <submittedName>
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        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">AA958_16720</name>
    </gene>
    <organism evidence="2 3">
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        <lineage>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AKH83581">
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HATPase_c" evidence="1">
        <location>
            <begin position="11"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="132" mass="13948" checksum="CD19CE116A541715" modified="2015-07-22" version="1">MSTQSRMFARSARSVGKAREFVAAVLDAGDRADDIRLCVSELATNALRHTPAGRLFLVRVVVQEHLVHVEVHDAGDGEPHVCAPAETDDDGRGLLLVAALADDWGTSDRNGPGKAVWATFNLPGAPPATAVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6Y2</accession>
    <name>A0A0F7N6Y2_9ACTN</name>
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        <submittedName>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_13850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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        <property type="gene ID" value="AA958_13850"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_13850"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="3"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="348" mass="35934" checksum="084FD81C7F0101E5" modified="2015-07-22" version="1">MRVLVTGGAGFIGSHVVSALAERGHEAVVLDVRDGGPPGHTCDAYRRGDVRDRDAVAAALAGVDAVCHQAAMVGLTEDFADAPAYVGVNDLGTAVLLAAMADAGVRRLVLAGSMVVYGEGRYDCAAHGPVRPRPRAAADLAGGRFEPRCPRCGAELAPGLVAEDAPVDPRSVYAATKLAQEHLAGVWARVTGACAVSLRYHNVYGPGMPRDTPYAGVASFFRSALARGEAPRVYEDGAQRRDFVHVRDVAEANVRALEAVYGDGAAAGALTAYNAGSGDVHTVGELATALAAAYGGPAPRVTGEYRLGDVRHITADSARLRAELGWRPAVGFAEGVTEFAKSPLGAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N754</accession>
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        </submittedName>
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    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF02674">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH83228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="399" mass="42066" checksum="8B7905610190DF5E" modified="2015-07-22" version="1">MNVLDILLVAAAVWFAVVGYRQGFVVGVLSVCGFVGGGLLAIYLLPVIWDLATDGAALGPTAAFGAIVLVLIAASVGQGLTTHLGNQLRQYITWSPARSLDATGGALVNVVALLLVAWLLGTALASTTLPTVAREVRASKVLNGVAEVMPKSADTWFGEFSSVLSENRFPQVFAPFQSEQITNVPAPDPALVSSPVVEQARKSIVKVVGTAQSCGKVLEGTGFVFAPQRVMTNAHVVGGVDEPTVQIGGEGRLYDGEVVLYDWERDIAVLEVPELDAPALPFDQNDASRGDDAIVAGFPENGGFDVRAARVRDRITANGPDIYRRGTVNRDVLSLFTLVRQGNSGGPLLTPEGAVVGVVFARSMDDKDTGYALTVDEVRDDIERGRTASQPVDSDSCAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7A5</accession>
    <name>A0A0F7N7A5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_11190</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_11190"/>
    <dbReference type="EnsemblBacteria" id="AKH82702">
        <property type="protein sequence ID" value="AKH82702"/>
        <property type="gene ID" value="AA958_11190"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_11190"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2358"/>
    <dbReference type="OrthoDB" id="1688736at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="334"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="376"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="434"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="102"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH82702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="465" mass="49195" checksum="0A36B9392A0449F4" modified="2015-07-22" version="1">MSTSSAGGAAESAAPTPLAPPGSTSQEPEEQKLSKPPRSVVRTKSWITVAFLLPAVVLLGTLVLYPIGYSVYRSLFDVSGDEFIGLDNYTELFSDDRIRTALRNNLIWVLVAPAVCTALGLIFAVLTEKVRWGTAFKMVVFMPMAISMLAAGVIFSLVYQNEPERGAANAAWTTIHDTFSDPAPWPGARPRPNADLKGPDKGPFTSDATVSAGETALLPLVAVKPQDAAGEEPAAKPQPAGDGVSGTVWLDFKPGGGEPDVVDSGEKALKDIKVEAVKDGKVVASATTASDGTFTLPAAADGAQLRLPSSNFAEAYGGVDWLGPSLVTPAVIAAYVWMWAGFAMVLIAAGLASVPRELMEAARVDGANEWQVFRRITVPVLAPVLAVVLVTLMINVLKIFDLVYIIVPSARLEDGNVLAVELFQQAFAGTEPDLGVGSAISVVLLLLVIPVMIFNIRRLRKESGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7G1</accession>
    <name>A0A0F7N7G1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_19215</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017256.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_19215"/>
    <dbReference type="EnsemblBacteria" id="AKH83961">
        <property type="protein sequence ID" value="AKH83961"/>
        <property type="gene ID" value="AA958_19215"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_19215"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4040"/>
    <dbReference type="OrthoDB" id="837566at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="412"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="457"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="474"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH83961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="570" mass="60062" checksum="B2653FC0D66F9110" modified="2015-07-22" version="1">MTAVLPPVTAPELDLFLATALLAAFAIVLAVRVLRRRSARSRERRGSAAVAIAAVAALACTAYSADTSWRFAADYLDMAGTAERAGMFAAAELALFATALMARQNLTTQGAPGVPGTLVWIISGVQVIPAYAESGPVGGTVRAFVGPIMAAVLWHLAMGIELRLRTPGAASRSLIATLGREARERLLSRLGIAARDRDAAQITRDRATDRAVALAARLAEQTPEQQHDRRGRRLTRRLSKALGKAEVGTDPDQRARLLRQLAARRHAVALATIALPSPWSPPTAGTLDTAVPAPTVPVAGDRGPNRLRGPVPAPMGSRINPPTGSVPAPGPHTPSEAGDLGPNPPRGPVPAPAPHHPGTGTEREDREPGTAMTPNRGPVPTSMNDQVNPPTVPDPPVPAPGPHTEAGDRGPNPPQGPVPAPAPHHPGTGTEPEHREPGTATTPARGPVPAPAEDHPGTEPTPHRGPGRDRGPGTVRRKKAHTKKSRGKRSSRSRTPRQQDPALSVDQLVQQVRPHVPDLLARDGNTAVTRVQLREILRREGLVGGRNSQLSLVLHELRSDNHATTTKDTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7L5</accession>
    <name>A0A0F7N7L5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_15495</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016690.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH83378">
        <property type="protein sequence ID" value="AKH83378"/>
        <property type="gene ID" value="AA958_15495"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_15495"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3261"/>
    <dbReference type="OrthoDB" id="2033455at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH83378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="85" mass="9833" checksum="BCDE9021DCFDEF61" modified="2015-07-22" version="1">MTHTFPEDLVQTQRDWYAVYRRLAEEPRHSASETAVLRRRLLRLSVRVSTHPYWQTTGGRLPAARMALKEAAWAEVRAETAARKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7Q9</accession>
    <name>A0A0F7N7Q9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">50S ribosomal protein L25</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">General stress protein CTC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rplY</name>
        <name evidence="6" type="synonym">ctc</name>
        <name evidence="9" type="ORF">AA958_12010</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016172.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_12010"/>
    <dbReference type="EnsemblBacteria" id="AKH82837">
        <property type="protein sequence ID" value="AKH82837"/>
        <property type="gene ID" value="AA958_12010"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_12010"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2527"/>
    <dbReference type="OrthoDB" id="1673077at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00495">
        <property type="entry name" value="Ribosomal_L25_TL5_CTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01334">
        <property type="entry name" value="Ribosomal_L25_CTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020056">
        <property type="entry name" value="Rbsml_L25/Gln-tRNA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029751">
        <property type="entry name" value="Ribosomal_L25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_L25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020057">
        <property type="entry name" value="Ribosomal_L25_b-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037121">
        <property type="entry name" value="Ribosomal_L25_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001021">
        <property type="entry name" value="Ribosomal_L25_long"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01386">
        <property type="entry name" value="Ribosomal_L25p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14693">
        <property type="entry name" value="Ribosomal_TL5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="SSF50715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00731">
        <property type="entry name" value="bL25_bact_ctc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_TL5_C" evidence="8">
        <location>
            <begin position="99"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="180"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH82837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="204" mass="21482" checksum="88A5ADC6BE038516" modified="2015-07-22" version="1">MAEYKITAEPRTETGKGAARRLRREDKVPGVVYGHGADPRHVALPSYDLLMALKTSNVLISLDLDGKSELVIPKDVQRDVLRTGVLKHVDLLVVKRGEKVTVEVPIQVEGDLAPGQNLLEHTLHALPVEAEATNIPESVTVSVEGLEAGATVAAKDVKLPAGVTLAVDGEDPVLHVVAPQAEESAAEGEGAEGEAAADEGKSED</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7Z8</accession>
    <name>A0A0F7N7Z8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Probable M18 family aminopeptidase 2</fullName>
            <ecNumber evidence="9">3.4.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">apeB</name>
        <name evidence="12" type="ORF">AA958_16580</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CNQ-509</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 10">Belongs to the peptidase M18 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.-" evidence="9"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016863.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_16580"/>
    <dbReference type="EnsemblBacteria" id="AKH83558">
        <property type="protein sequence ID" value="AKH83558"/>
        <property type="gene ID" value="AA958_16580"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_16580"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3489"/>
    <dbReference type="OrthoDB" id="304020at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00467">
        <property type="entry name" value="Aminopeptidase_M18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022984">
        <property type="entry name" value="M18_aminopeptidase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001948">
        <property type="entry name" value="Peptidase_M18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023358">
        <property type="entry name" value="Peptidase_M18_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28570">
        <property type="entry name" value="PTHR28570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02127">
        <property type="entry name" value="Peptidase_M18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00932">
        <property type="entry name" value="AMINO1PTASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9 10" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="6 9 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9 10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4 9 10" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9 10" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="438"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AKH83558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="462" mass="48102" checksum="4F0FF2622489CDBB" modified="2015-07-22" version="1">MTPAPPPRFDRSHTDDLAGYLTASPTPYHAVAEAARRLEKAGFTQLRETDAWDASAGGRYVLRGGALIAWYVPEGSAPETPFRIVGAHTDSPNLRVKPVPDTGGHGWRQIAVEVYGGPLLNSWLDRDLGLAGRLTLRPGATHAGASAGGGGHGPGGAEVRLVNVDRPLLRVPQLAIHLDRGVVTEGLKLDKQRHSTPIWGLGPVHEGDLIEFLAAEAGVAAGDVIGWDLMVHSVEPPAYLGRDRELLAGPRMDNLLSVHAGVAALAAAAGGTAHARRAMGDAGTPPTTIPVLAAFDHEETGSQSDTGAEGPLLGTVLRRTVAARGGTYDDTARALAGSVCLSSDTGHAVHPNYPERHEPGHHPMPNGGPILKVNVNQRYATDGAGRGILATACERAGVPWQTFVSNNAMPCGTTIGPITAARHGITTVDIGVAILSMHSARELCGAEDPHLLAGALAAFLTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N812</accession>
    <name>A0A0F7N812_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_16535</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016854.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_16535"/>
    <dbReference type="EnsemblBacteria" id="AKH83549">
        <property type="protein sequence ID" value="AKH83549"/>
        <property type="gene ID" value="AA958_16535"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_16535"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3480"/>
    <dbReference type="OrthoDB" id="1911275at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="12"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH83549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="220" mass="24053" checksum="F67F186BF7692BB9" modified="2015-07-22" version="1">MPPSPAAPAKPAPAADRVYAHVKQGVLERRYEGGTMLTEGELADAVGVSRTPVREALLRLQAEGLLELYPKKGAFVLPVSAQEIADVVETRMLVEEHAARRSVPAPAALLTRLEELLEEQRRHVEADDRAAASVTDRCFHAEIVRNAGNAILVRLYDQLRDRQLRMGVALMNAQPDRMRRSLAEHAEILQALRSGSADTAAAAVHGHVASVRDLLRGDLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8F7</accession>
    <name>A0A0F7N8F7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_17990</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017085.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_17990"/>
    <dbReference type="EnsemblBacteria" id="AKH83783">
        <property type="protein sequence ID" value="AKH83783"/>
        <property type="gene ID" value="AA958_17990"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_17990"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3784"/>
    <dbReference type="OrthoDB" id="1428062at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH83783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="277" mass="29524" checksum="72106D2640570461" modified="2015-07-22" version="1">MSHDDDYVDYASPEPGTRTRFAEGDNDGRYDTRRGGRVSPSRAMVTVVGVVVLLIAAIAFANRGGNTDDDPESTANPDTKAQPTAPTGDTPVKTPVNGIPTGFPHSAEGAQSAAANYTVPLAGAGMFDEDERADIVRALYVPGVAEARLSALDEVYDDPAFLQRIGLEEDGTAPTGTTFVSRINPVGASVKAYTDDTAKIAVWYSALFGLAGEDSENPVTESWYTTTYELQWADGDWKVSDYTQKDGPVPVGRDQTASSAEDMAEAIEEFGGFTYAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8H1</accession>
    <name>A0A0F7N8H1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Inositol 2-dehydrogenase</fullName>
            <ecNumber evidence="1">1.1.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Myo-inositol 2-dehydrogenase</fullName>
            <shortName evidence="1">MI 2-dehydrogenase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">iolG</name>
        <name evidence="4" type="ORF">AA958_13315</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the oxidation of myo-inositol (MI) to 2-keto-myo-inositol (2KMI or 2-inosose).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>myo-inositol + NAD(+) = H(+) + NADH + scyllo-inosose</text>
            <dbReference type="Rhea" id="RHEA:16949"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:17811"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.18"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfo/Idh/MocA family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.18" evidence="1"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016378.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_13315"/>
    <dbReference type="EnsemblBacteria" id="AKH83047">
        <property type="protein sequence ID" value="AKH83047"/>
        <property type="gene ID" value="AA958_13315"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_13315"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2801"/>
    <dbReference type="OrthoDB" id="1465613at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050112">
        <property type="term" value="F:inositol 2-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019310">
        <property type="term" value="P:inositol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01671">
        <property type="entry name" value="IolG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023794">
        <property type="entry name" value="MI/DCI_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0520">NAD</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="2">
        <location>
            <begin position="3"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="3">
        <location>
            <begin position="139"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH83047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="338" mass="36012" checksum="D2C6117B9A2D9010" modified="2015-07-22" version="1">MTVRIGVVGTGAIGREHIERISRVISGARVSAVADIDAALAEKAAAEAGGARVADAADIAGSLIAADDVDAVLVSSWHAAHAEHVLAAIAAGKPVLCEKPLATTAEDALRVLAAEEAFGRRLVQVGFMRRYDPGYRELKRVIADGGIGRPLMMHCAHRNRSAPERYTTEMAAQDTGVHEIDAARWLLDDEIVSAQVILGRATERRFPHLRDPQFMLFETAGGVRIDLEVFVNCQYGYDIQCETVGETGLIRLPDPARAQVRAAARVGTEIDQEWGGRFAEAFDVEVQAWVDSVAAGAATGPSAWDGYAATAVAAATVEAQRTGAVVDVDLVERPAFYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8N0</accession>
    <name>A0A0F7N8N0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ligand-binding protein SH3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_18410</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017151.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH83853">
        <property type="protein sequence ID" value="AKH83853"/>
        <property type="gene ID" value="AA958_18410"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_18410"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3865"/>
    <dbReference type="OrthoDB" id="1990300at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000390">
        <property type="entry name" value="Small_drug/metabolite_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045324">
        <property type="entry name" value="Small_multidrug_res"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30561">
        <property type="entry name" value="PTHR30561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00893">
        <property type="entry name" value="Multi_Drug_Res"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH83853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="106" mass="10844" checksum="648782B9EDF7C340" modified="2015-07-22" version="1">MHWLHLGLAVVFEIAVALSAGKARGFTRPAWTAATLISGGVATYLLSRALLTFDVGAGYAIWTSVAGVGIVVLGVLLFGQRLGWRKLLGIAAVIAGVVGLQLSGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8Y6</accession>
    <name>A0A0F7N8Y6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_25420</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018251.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_25420"/>
    <dbReference type="EnsemblBacteria" id="AKH85000">
        <property type="protein sequence ID" value="AKH85000"/>
        <property type="gene ID" value="AA958_25420"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_25420"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5358"/>
    <dbReference type="OrthoDB" id="1479518at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="119"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="260"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="303"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="117"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH85000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="335" mass="36870" checksum="79F116DDE1DC07C3" modified="2015-07-22" version="1">MFAYLIRRLMAAVVLLFVVSAITYAIFFVLPRLAGSTPDQLAAQYIGKSPDPKTIDAVKKNLGLDDPVYVQYWDFIRGIFAGREFNFGPDPSQCNAPCLGYSFRKHVEVWPEMMDRLPVTASLAIGAAVLWLISGVTTGVISALRPGSIFDRAAMGIALAGVSLPMFFTGTVALALFVYHWQIFPNEYTPLTDNPVRWFQGLMLPWFSLAFLYSALYARLTRAGMLETMGEDYIRTARAKGLKEPVVIARHGLRSALTPIVTIFGMDFALLLGGAVITETVFSFNGVGSWAVQSINENDLPPILGVTLFAAFFIVICNLVVDFVYAAIDPRVRVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N909</accession>
    <name>A0A0F7N909_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Acetolactate synthase</fullName>
            <ecNumber evidence="4 8">2.2.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">AA958_25555</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>H(+) + 2 pyruvate = (2S)-2-acetolactate + CO2</text>
            <dbReference type="Rhea" id="RHEA:25249"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="2.2.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="8">Binds 1 thiamine pyrophosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.6" evidence="4 8"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018276.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_25555"/>
    <dbReference type="EnsemblBacteria" id="AKH85025">
        <property type="protein sequence ID" value="AKH85025"/>
        <property type="gene ID" value="AA958_25555"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_25555"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5388"/>
    <dbReference type="OrthoDB" id="391134at2"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00055"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02015">
        <property type="entry name" value="TPP_AHAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012846">
        <property type="entry name" value="Acetolactate_synth_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039368">
        <property type="entry name" value="AHAS_TPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
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</entry>
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH84641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="210" mass="21984" checksum="90F81C992C232A2D" modified="2015-07-22" version="1">MTPGDPAAATRAQGSATAALHWARQRALEAGLRQVSAGAGAALRLLAATAGAKAVVEIGTGTGVSGIHLLQGMRPGGVLTTVDPEPERQQFARQAFRAAGFAANRARIIVGRALDVLPRLADGSYDMVFCDGDPLECLEYLGESLRLLRPGGVVCFEGVFADGRTVDSAAQPDEVQKVRELLRAVKESRELMPALLPVGDGLLCAVKREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9J1</accession>
    <name>A0A0F7N9J1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Membrane protein</fullName>
        </submittedName>
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        <name evidence="7" type="ORF">AA958_20120</name>
    </gene>
    <organism evidence="7 8">
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        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
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                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_20120"/>
    <dbReference type="EnsemblBacteria" id="AKH84109">
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        <property type="gene ID" value="AA958_20120"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_20120"/>
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    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:transmembrane transporter activity"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="MFS_dom"/>
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        <property type="entry name" value="MFS_trans_sf"/>
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        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF103473"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
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            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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            <end position="306"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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            <end position="338"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="350"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="378"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="9"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH84109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="438" mass="44963" checksum="82E7F4EA299C5960" modified="2015-07-22" version="1">MRRETGAAALRRIQVGNALSAFGSGFTVPYTFLYVSRVRDLGSTTAGVALAGFAMAALLVLPFTGRFIDRRGPLPVALFGTVAAAAGALSLGLASTAPMVLASTLVMGAGMAVIQPALATMIVWCSTTVTRSRAFATQFFLNNLGLGVGGLLGGLLVEEEHAGSFVRLFAIESVMFLVLGAVVATVRLPRGTRAAHAVPAGEGARGRWRILLADRAMVWLCVLGFVMFFACYGQFESGLSAFAVEVSGISPSTLGVALAANTAVIVVAQFAVLRLVERRRRSRVIAAVGLIWTVAWLVAGASGWVAGGQAMATAAIISTYALFGLGEAMLSPTVAPLVADLAPGSHIGHYNSVFALVKQLALAIGPAVGGLLAGAGAYGAYISMLVVCSLGITVMGLRLGRRLTPVQDYPRLAGTVQVAAHKPAAAGAEPEPAPVQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9N2</accession>
    <name>A0A0F7N9N2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Rrf2 family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_20870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017523.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_20870"/>
    <dbReference type="EnsemblBacteria" id="AKH84238">
        <property type="protein sequence ID" value="AKH84238"/>
        <property type="gene ID" value="AA958_20870"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_20870"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4399"/>
    <dbReference type="OrthoDB" id="1794390at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030489">
        <property type="entry name" value="TR_Rrf2-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000944">
        <property type="entry name" value="Tscrpt_reg_Rrf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33221">
        <property type="entry name" value="PTHR33221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02082">
        <property type="entry name" value="Rrf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00738">
        <property type="entry name" value="rrf2_super"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01332">
        <property type="entry name" value="HTH_RRF2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51197">
        <property type="entry name" value="HTH_RRF2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH84238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="159" mass="17425" checksum="F393DA7991D35782" modified="2015-07-22" version="1">MNMGEGVEWGLHSCLTLAWLRDAGPVPIRRLAVWFDLPQEYLKKRLQALARAGILDSTPGARGGFSLAREPERITLMDVVTALEGPLEPFVCTEIRQQGHGGQGAGREFARPCGVATAMRRAELAWRRELAGQTVADLMAAAPKASAERTRRQYARLTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAC2</accession>
    <name>A0A0F7NAC2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase type 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_17220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016966.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH83662">
        <property type="protein sequence ID" value="AKH83662"/>
        <property type="gene ID" value="AA958_17220"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_17220"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3621"/>
    <dbReference type="OrthoDB" id="1515497at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="68"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="252" mass="27092" checksum="4C223916D503F7E0" modified="2015-07-22" version="1">MPRGGPAAARWDRLYETGRAEYIDRPGNPATTRRVLRGLDRFQRLTLGYRTCARLTAAEFGPAPHPRVLELGAGCGRLAYRILRAHPTARVTASDVNPRVVEELRAGPLGRHPRARCAVVDATAIDAPAGAYDVAVMAMSLHHLPPAGVLALLREGTRVARTLLLVDGWRHPLCLVSVPLMFLTGGPAQAHDGLISLRKVYGAAAVRALAGMCGAPLRVHTRFALPGYLVATATRSSYAPAPAVPTRLRTRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAE1</accession>
    <name>A0A0F7NAE1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_17345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016986.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_17345"/>
    <dbReference type="EnsemblBacteria" id="AKH83682">
        <property type="protein sequence ID" value="AKH83682"/>
        <property type="gene ID" value="AA958_17345"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_17345"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3647"/>
    <dbReference type="OrthoDB" id="1832160at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HATPase_c" evidence="1">
        <location>
            <begin position="28"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="142" mass="15728" checksum="92B745AE6297DE14" modified="2015-07-22" version="1">MTTDQNRMASTSVMKWQWRRHPRCVGLARAQLRKALAGWGLTGIEEPVSLVVSELMTNAVVHARVPPGREILTRFVRQDGGVLIEVHDASDVWPEKRVPDECGGYGLLMVEKLAVRWGVSARNGIGKRVWAVVVDTTTAPSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-10-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAN3</accession>
    <name>A0A0F7NAN3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD-linked oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_22755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017810.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH84553">
        <property type="protein sequence ID" value="AKH84553"/>
        <property type="gene ID" value="AA958_22755"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_22755"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4785"/>
    <dbReference type="OrthoDB" id="330793at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="1">
        <location>
            <begin position="34"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="438" mass="46113" checksum="70675B0DB1800946" modified="2015-07-22" version="1">MTIVNDLRAAVRGRVLTPGDEGFDAARRPWNLAVDQRVAVVVDAADTADVAAVVRRARLDGLVVLAQPSGHGASGDTDDAILLRTGGLGGVEIRPQERLARVGAGVKWGEVLTAAGPHGLTGLAGSSPAVSVTGYTLGGGLSWFSRAHGFAANSVRAFDVVEADGAQRRVTAESDPELFWALRGGSGEFAVVTAVEFDLHPAPELYGGRMVWPAAAAPAVLEAYREVTATAPDELTVWYDLLQFPGAPARVAVDATCLSPPGEAEALLRHFDKIDGRMSDSRGPLPVAELGTITAEPTDPGPGMSRAELLTELTDDVAEALLAEPIDPLLSVQLRHLGGALARPPADAGACGELTEPYLLYTFGLPATPEKATAIRERQRELAAALTPYTSGRKPYTFLAPGERAAHSFTPAALGRLRALKRKRDTRGTFRTNYPVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAP4</accession>
    <name>A0A0F7NAP4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Macrolide ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_22615</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017787.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_22615"/>
    <dbReference type="EnsemblBacteria" id="AKH84529">
        <property type="protein sequence ID" value="AKH84529"/>
        <property type="gene ID" value="AA958_22615"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_22615"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4758"/>
    <dbReference type="OrthoDB" id="1181903at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042953">
        <property type="term" value="P:lipoprotein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015854">
        <property type="entry name" value="ABC_transpr_LolD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24220:SF654">
        <property type="entry name" value="PTHR24220:SF654"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="17"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="49"/>
            <end position="56"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH84529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="238" mass="24960" checksum="7C2CC9746A8B1EF1" modified="2015-07-22" version="1">MSTTPVPGPLGEPAPILTATALRKVYAGTPALDGADFAVAAGETVAVMGPSGSGKSTLLHCLAGIVPADAGTVTYAGRDLAELSDAERSALRRREFGFVFQFGQLVPELTCVENVALPLRLTGLGRRDAERAARPWLERLEVDDIAHKRPGEVSGGQGQRVAVARALATTPRVIFADEPTGALDSLNGERVMELLTDAAQDSGAAVVLVTHEARVAAYADREIVVRDGRTRSLEPAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAV0</accession>
    <name>A0A0F7NAV0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aminopeptidase N</fullName>
            <ecNumber evidence="4">3.4.11.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">AA958_26615</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal amino acid, Xaa-|-Yaa- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide.</text>
            <dbReference type="EC" id="3.4.11.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.2" evidence="4"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_26615"/>
    <dbReference type="EnsemblBacteria" id="AKH85211">
        <property type="protein sequence ID" value="AKH85211"/>
        <property type="gene ID" value="AA958_26615"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_26615"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5600"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="SSF63737"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 15" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6 15" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519445" description="Aminopeptidase N" evidence="12">
        <location>
            <begin position="39"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M1_N" evidence="14">
        <location>
            <begin position="175"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M1" evidence="13">
        <location>
            <begin position="276"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="33"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="488"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AKH85211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="527" mass="57097" checksum="1EA33D14EED93F94" modified="2015-07-22" version="1">MLRSVHPRRPLRHALLAAAVLATLAAAPAAPAVSTAPAAPGRTGAQDGPPRPAGIGDPLFPHLGNPGYDVLGYDIALAYPGRNDAPLTARTEITARVTGRLPRINLDFTHGTVRDVTVNGRPAAHARAGEDLVVTPGRTLHPGEPLRIAVRHTSDPRGNGGGWIRTKDGLAMANQADAAHRVFPGNDHPADKARFTFRVTAPQDLTVVANGLRLSRERAGARTTWTYRTAHPMATELAQVSIGRSAVLRGTGPHGLPLRHVVPERDRRTARAVVDRTSAQIAWMERYVGRYPLESYGVLSVDAPLNFALETQTLSVFGRDFLRAVAQHPKRAEGVLVHELAHQWFGNSVTPRRWSDLWLNEGHATWYEALFTDERHDRGSLVRRMRAAYGQSDDWRRAGGPPAAPRRPADGGQLELFRPVVYDGSALVLYALRQEIGAPDFEELERAWVTRHRDGTAGTADFVALASEVAGRDLEDFLHSWLYGERTPPMPGHPGWKAAKPATPGKAAAPAGPAKGAEPPEAGKPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAW2</accession>
    <name>A0A0F7NAW2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protocatechuate 3,4-dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_29250</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the intradiol ring-cleavage dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018879.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_29250"/>
    <dbReference type="EnsemblBacteria" id="AKH85650">
        <property type="protein sequence ID" value="AKH85650"/>
        <property type="gene ID" value="AA958_29250"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_29250"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6166"/>
    <dbReference type="OrthoDB" id="1456634at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018578">
        <property type="term" value="F:protocatechuate 3,4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019439">
        <property type="term" value="P:aromatic compound catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000627">
        <property type="entry name" value="Intradiol_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015889">
        <property type="entry name" value="Intradiol_dOase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012786">
        <property type="entry name" value="Protocat_dOase_a"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00775">
        <property type="entry name" value="Dioxygenase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49482">
        <property type="entry name" value="SSF49482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02423">
        <property type="entry name" value="protocat_alph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="INTRADIOL_DIOXYGENAS" evidence="4">
        <location>
            <begin position="35"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH85650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="183" mass="19362" checksum="F7A15DD8A46DC6FF" modified="2015-07-22" version="1">MSLPPTPSQTVGPFHGYALPFAGGGDLAPAGHPDAIAVHGCVRDGAGAPVPDALVEIWQPAPDGSRRGAPGSLRRDQVTGAVIGRDGVRFTGFGRIPTDADGHYAARTLPPGGVPYLSVALFARGLLHHLYTRMYLDDTADGLLSSLPPDRRATLIAAREPNRTYRFDIRLQGEGETVFLDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAY8</accession>
    <name>A0A0F7NAY8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphoribosylformylglycinamidine synthase subunit PurL</fullName>
            <shortName evidence="5">FGAM synthase</shortName>
            <ecNumber evidence="5">6.3.5.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Formylglycinamide ribonucleotide amidotransferase subunit II</fullName>
            <shortName evidence="5">FGAR amidotransferase II</shortName>
            <shortName evidence="5">FGAR-AT II</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Glutamine amidotransferase PurL</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Phosphoribosylformylglycinamidine synthase subunit II</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">purL</name>
        <name evidence="9" type="ORF">AA958_18370</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + H2O + L-glutamine + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide = 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ADP + H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17129"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the FGAMS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.3" evidence="5"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017145.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_18370"/>
    <dbReference type="EnsemblBacteria" id="AKH83847">
        <property type="protein sequence ID" value="AKH83847"/>
        <property type="gene ID" value="AA958_18370"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_18370"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3857"/>
    <dbReference type="OrthoDB" id="26038at2"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00128"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004642">
        <property type="term" value="F:phosphoribosylformylglycinamidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00420">
        <property type="entry name" value="PurL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010074">
        <property type="entry name" value="PRibForGlyAmidine_synth_PurL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041609">
        <property type="entry name" value="PurL_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43555">
        <property type="entry name" value="PTHR43555"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18072">
        <property type="entry name" value="FGAR-AT_linker"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001587">
        <property type="entry name" value="FGAM_synthase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01736">
        <property type="entry name" value="FGAM_synth_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 5" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FGAR-AT_linker" evidence="8">
        <location>
            <begin position="20"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS" evidence="6">
        <location>
            <begin position="96"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="7">
        <location>
            <begin position="211"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS" evidence="6">
        <location>
            <begin position="476"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="7">
        <location>
            <begin position="593"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="103"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="330"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
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        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
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        <location>
            <position position="258"/>
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        <ligand>
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        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:18420"/>
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        <location>
            <position position="518"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
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        </location>
        <ligand>
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        <ligand>
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        </location>
        <ligand>
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        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
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    </evidence>
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            <dbReference type="HAMAP-Rule" id="MF_00420"/>
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    </evidence>
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        </source>
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        </source>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH83847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
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    </evidence>
    <sequence length="757" mass="80289" checksum="F62E9D02B0BD4D15" modified="2015-07-22" version="1">MTLDTVKHASGSPGTEQPWAELGLKQNEYEQIREILGRRPTGAELAMYSVMWSEHCSYKSSKVHLKQFGDKAPPSDALLVGIGEQAGVVDVGQGYAVTFKVESHNHPSYVEPYQGAATGIGGIVRDIIAMGARPVAVMDPLRFGAADHPDTKRVLPGVVAGIGGYGNCLGLPNIGGEVVFDPCYQGNPLVNALCVGVMRHEDIHLAKAAGVGNKVILYGARTGGDGIGGASILASETFTDTSAADAAGAKPSKRPSVQVGDPFQEKLLIECTLEAFHEDLVVGIQDLGAAGLSCATSELASNGTGGMRVELDVVPLRDATLSPEEILMSESQERMCAVVEPAKADRFLAICEKWDVTATVIGEVTDGDRLEIYWHGEQIVDVPPRTVAHDGPVYERPMARPGWLDALQADDAAKLPRPADGAELRAQVLRLVGSPNQADKSWITSQYDRFVLGNTVLAQPEDSGMIRIDEETGLGVALATDGNGRYAKLDPYAGAQLALAESYRNVAATGARPLAVTDCLNFPSPEDPAGMWQFAEACRGLADACRTLGTPVTGGNVSLYNQTGDQPIHPTPVVGVLGVIDDVARRTPMAFAQEGQLLYLLGETKEELGGSAWSQVVHDHLGGLPPAVDLERERLLAEILISASRDGMIDAAHDLSDGGLVQAVIESCLKGGHGARLVVPEGLDPAVFLFSESQGRAVVAVPRSEEMRFTDMCGARGLPATRIGVVDGDAVELQGQFTLPLAELRETYERTIPELFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NB08</accession>
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        <submittedName>
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    </gene>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
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        <text evidence="1">Belongs to the Fur family.</text>
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    </dbReference>
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    <keyword evidence="2" id="KW-0862">Zinc</keyword>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH84688.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NB64</accession>
    <name>A0A0F7NB64_9ACTN</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_18950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH83927">
        <property type="protein sequence ID" value="AKH83927"/>
        <property type="gene ID" value="AA958_18950"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_18950"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3978"/>
    <dbReference type="OrthoDB" id="2020344at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="179" mass="18744" checksum="F0169E639F9C27C0" modified="2015-07-22" version="1">MFSHPDFEAYDNVGRDTEQIEAAKHHTATRLDLITWAQADAAAFLADHPLPGSALPELDLAAYRSALAAAQSPAEVSVVTQHLLDAAAPVLQAVSDCLVEAAQWRNRHRDAPAGSPPKLLMAAASRARDVLAVADEADLARLRAEYDPAPAPPLPAPGRPSGLPPVSPGATSAGQTRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NC31</accession>
    <name>A0A0F7NC31_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_25305</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018229.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_25305"/>
    <dbReference type="EnsemblBacteria" id="AKH84978">
        <property type="protein sequence ID" value="AKH84978"/>
        <property type="gene ID" value="AA958_25305"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_25305"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5333"/>
    <dbReference type="OrthoDB" id="1958442at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005561">
        <property type="entry name" value="ANTAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012074">
        <property type="entry name" value="GAF_ANTAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03861">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036625">
        <property type="entry name" value="GAF_ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01012">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50921">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="ANTAR" evidence="3">
        <location>
            <begin position="172"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH84978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="244" mass="25809" checksum="FB3418C3C11D4C05" modified="2015-07-22" version="1">MPEESREEGLAAAFADLADTLDSDFDVEQHARRLALHCAELVDVSAAGVVLAADDGGAFTASASDERAHALEEAEAEWGEGPAVDCFRTARPMPAVPLAHARARADWPRFTGRALEMGFALVASAPMQARGTTVGALNLYRDRPGTLHAAQLRLGQALAGVAALGILQQRALAGQTAVAAQLQTALNSRIVIEQAKGALAQRRSIAVDEAFRLLRGHARNSRRPLAEVAREVVEEGLDPAPRDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCC2</accession>
    <name>A0A0F7NCC2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_21475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017605.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_21475"/>
    <dbReference type="EnsemblBacteria" id="AKH84342">
        <property type="protein sequence ID" value="AKH84342"/>
        <property type="gene ID" value="AA958_21475"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_21475"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4521"/>
    <dbReference type="OrthoDB" id="1186478at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="259" mass="27341" checksum="A9A219D47171F749" modified="2015-07-22" version="1">MTTALITGSTAGLGAAFARRLAASGYDLVLVARTAERLHAQAAELHERYGVETSVLPADLAAEEGIAAVEKRLGEAGAGQPVDLLVNNAGFGLKGRFLQVTLADELTMLKVHCEAVLRLTTAAAAAMRERSRGAVVNVASVAAFVPRGTYGASKSWVVQFTQGVARDLAGSGVRLMVLCPGFIRTEFHERAGMGTDDIPGWMWLDADKVAAEGLRDLRRGRTVSIPDPRYKALMGAAKLVPRGLLGRVSTGAGRKYGPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCL3</accession>
    <name>A0A0F7NCL3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH tetR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_31170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019164.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_31170"/>
    <dbReference type="EnsemblBacteria" id="AKH85936">
        <property type="protein sequence ID" value="AKH85936"/>
        <property type="gene ID" value="AA958_31170"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_31170"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6586"/>
    <dbReference type="OrthoDB" id="1437290at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011075">
        <property type="entry name" value="TetR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16859">
        <property type="entry name" value="TetR_C_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="20"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH85936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="198" mass="21496" checksum="A79728C21F2DA21B" modified="2015-07-22" version="1">MPESSRQPATAARRTGGRSARVRAAVLQATVDVVLERGADALSIAEVAQRAGVHETSIYRRWGTKSALALDAVLDRTRTDLPTPDTGALRTDLLALLHDTAAFVRTPLGGLLLRMAVQEDLAEYEAARDQFWTTRFAVGATVLDRAEARGELRPGVDRRLAFEALTGPLHTRLLLTREPLDETFLEGTVDLLLSGIAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCX9</accession>
    <name>A0A0F7NCX9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ribonuclease HII</fullName>
            <shortName evidence="11">RNase HII</shortName>
            <ecNumber evidence="11">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">rnhB</name>
        <name evidence="14" type="ORF">AA958_26715</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 11 12">Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11 12">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 11 12">Belongs to the RNase HII family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="11"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018465.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_26715"/>
    <dbReference type="EnsemblBacteria" id="AKH85228">
        <property type="protein sequence ID" value="AKH85228"/>
        <property type="gene ID" value="AA958_26715"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_26715"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5621"/>
    <dbReference type="OrthoDB" id="1685277at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="UniProtKB-UniRule"/>
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    </dbReference>
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        <property type="entry name" value="RNase_HII"/>
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        <property type="entry name" value="RNase_HII/HIII"/>
    </dbReference>
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        <property type="entry name" value="RNase_HII/HIII_dom"/>
    </dbReference>
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        <property type="entry name" value="RNaseH-like_sf"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0963">Cytoplasm</keyword>
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    <keyword evidence="10 11" id="KW-0464">Manganese</keyword>
    <keyword evidence="7 11" id="KW-0479">Metal-binding</keyword>
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    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase_HII" evidence="13">
        <location>
            <begin position="25"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="28"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
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        <location>
            <position position="120"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004065"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00007383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
            <dbReference type="HAMAP-Rule" id="MF_00052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AKH85228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="237" mass="25575" checksum="A2960C2EB7DCDD63" modified="2015-07-22" version="1">MSPYEPPTHRVERSLRATTGAKVVAGVDEVGRGAWAGPVTVCAAVTGLRRAPEGLTDSKLLTVKRREELAAELTGWVTAHALGHASSREIDELGMTACLRLAAGRALEALPVRPDAVILDGKHDYLGAPWRVRTVIKGDQSCVAVAAASVLAKVHRDARMTELAAARAEYEPYAFEDNAGYPSPVHRTALQDHGPTDLHRLSWAYMDGLDKWQHLKRPRIAPEAAELEAAGQLGLDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCZ5</accession>
    <name>A0A0F7NCZ5_9ACTN</name>
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        <submittedName>
            <fullName evidence="8">Glycosyl hydrolase</fullName>
        </submittedName>
    </protein>
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        <name evidence="8" type="ORF">AA958_23065</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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        </lineage>
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    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 18 family.</text>
    </comment>
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AKH84602">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="6" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
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        </location>
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        <location>
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            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="7">
        <location>
            <begin position="60"/>
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        </location>
    </feature>
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        <location>
            <begin position="29"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH84602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="460" mass="50917" checksum="DF26D1BC64C34C58" modified="2015-07-22" version="1">MHRRLVRRLAVAGCALSLLVTPGLTTAGATAATPGEAPHRTPAAAGQQGGDDHRGDRDEARRVGYFTQWGARDRAFLVKDLVTSGTAARLTHLNYAFGNVSPDGKCFEDDIPGEGDAFTDYRRTMTAAESVDGRADSPRQRLAGNFNQIRELKAEYPDLKVMMSLGGWAWSTYFSDAVRTPESRRQFVSSCIDLFIKGNLPRIDGRGGPGSAAGVFDGIDLDWEWPNYPGDVDTVYRPEDKENFTAVVAEFRRQLDRVERSREGRGRHLLLTAFLPANANAMDAGYETRKLFPHLDYATLQGYDLHGAWEKNTNQQSAIHSPDDSLQQVVDDWLLRGAPRDKLVLGIPFYGRGWKGVEGGGTGFNQPAAGAAPGTWEAGFEDYKVLKEFAASGEYEVYRDRKNGHAWLFDGSTFWTYDDPKVIAQKAEYIDDRNLGGAMVWSLDGDDDGELYRVLDRGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7ND45</accession>
    <name>A0A0F7ND45_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_27215</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH85308">
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        <property type="gene ID" value="AA958_27215"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_27215"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5734"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003284">
        <property type="entry name" value="Sal_SpvB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03534">
        <property type="entry name" value="SpvB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0843">Virulence</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH85308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="110" mass="12377" checksum="3903971B283C6627" modified="2015-07-22" version="1">MVFGYGEHDEDAPAPGEVLPWPVRADPWSTRRPGFEVRTYRPCRRVLMFHRTPELGPRPQSASALLLGYDEDPAATRLVSLTHRGYVPDGRGYAYAELPRLTFGYTGRTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7ND59</accession>
    <name>A0A0F7ND59_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_32515</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019388.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_32515"/>
    <dbReference type="EnsemblBacteria" id="AKH86161">
        <property type="protein sequence ID" value="AKH86161"/>
        <property type="gene ID" value="AA958_32515"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_32515"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6863"/>
    <dbReference type="OrthoDB" id="2089619at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041678">
        <property type="entry name" value="TetR_C_16"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17920">
        <property type="entry name" value="TetR_C_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="13"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH86161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="188" mass="20165" checksum="D9B166511E0D9424" modified="2015-07-22" version="1">MSTPAPAPRRDAETSKLAILRAARYLLARRPHADITLKDVAERAGVSPPLIVKYFGNKNALFAGVMSFETDASALLDAPLGELGAHMVRHILEGQRERGVDPLLRIAFAPLHGQDGDVLRVNFRNQVVDHLALRLAGPDAGLRAELAVAQLVGLGVMYGIARGPALRAGAAEDVVRRFAPTVQMLLTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDE0</accession>
    <name>A0A0F7NDE0_9ACTN</name>
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        <submittedName>
            <fullName evidence="8">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_27655</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">TetR is the repressor of the tetracycline resistance element; its N-terminal region forms a helix-turn-helix structure and binds DNA. Binding of tetracycline to TetR reduces the repressor affinity for the tetracycline resistance gene (tetA) promoter operator sites.</text>
    </comment>
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        <property type="protein sequence ID" value="AKH85383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018617.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH85383">
        <property type="protein sequence ID" value="AKH85383"/>
        <property type="gene ID" value="AA958_27655"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_27655"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5826"/>
    <dbReference type="OrthoDB" id="1570162at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004111">
        <property type="entry name" value="Repressor_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003012">
        <property type="entry name" value="Tet_transcr_reg_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02909">
        <property type="entry name" value="TetR_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00400">
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="7">
        <location>
            <begin position="34"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="5">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH85383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="245" mass="26465" checksum="9763AD973C294FA7" modified="2015-07-22" version="1">MESDGSEGGGSRTAAAGRGVWLRKGPERPGRASPLSQARIADAAVALLDEGGADRLTMRGLAQRLEVSATALYWHVASREDVLDLAFDHIFAQVPIPEPGPEWALDVERLVVGWHAAMLRHPWSPALVGRPMLGPNVLARTEFLQSALVRGGLTGRALALATHLLANYAIGAALVEATWQRGRDPAVRAEAQAHLAARTDLYPTLHEHGHLDDRWPDEELFAAGVHTILGAVTHDAAARRTRRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDJ3</accession>
    <name>A0A0F7NDJ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_33395</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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    </dbReference>
    <dbReference type="RefSeq" id="WP_047019536.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_33395"/>
    <dbReference type="EnsemblBacteria" id="AKH86311">
        <property type="protein sequence ID" value="AKH86311"/>
        <property type="gene ID" value="AA958_33395"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_33395"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.7053"/>
    <dbReference type="OrthoDB" id="1793376at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH86311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="202" mass="21768" checksum="E67CEEFFEDDFA25D" modified="2015-07-22" version="1">MSAPDPPASGPAPAALARELRGLEPSCGPVRLVAVDGHAGSGKTTFAGRLAAALGGAPVLRLDDLATHREFFGWTGRLRRQVLDPLAAGRPAVYDAYDWDARAFTARRTLPPAPVVLVEGVGAGRRELRPHLARLLWMEVPAAEAWARGRERDGPGLAEFWDDWERAERAHFSADPSRPYAGLLVVRRGDAYRLVPGPASAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDJ5</accession>
    <name>A0A0F7NDJ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_28295</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018728.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH85494">
        <property type="protein sequence ID" value="AKH85494"/>
        <property type="gene ID" value="AA958_28295"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_28295"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5964"/>
    <dbReference type="OrthoDB" id="1387978at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="186"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="3">
        <location>
            <begin position="221"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH85494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="435" mass="44730" checksum="44D0F46B08E20717" modified="2015-07-22" version="1">MGTLDGQRENAGGGRARDPAERGGRASTGGAADAGDAAGAADRPDSPRTGAAHASPRHNGRAGSAGAPRADTVPGSAQADGGSSGHAGNAPGPAHPGGPLGTVRGEDSARRHAAAGAARRSSRLRLALVLAGGLPLLPVSGVLGFRVAGGDGVSPLPQLAAFLPWLLVPGGFGLLLMGLARSRAGVVWALVVVAGTAWFVRPYESAAEPPSSPPREEFRLLSANLRFGDATPALRTALRAYEPDVALVQECDSRCVEALRGPALQAAYPYRVIDGGDPAEGSAILSRYPLTEEPGVPGTLSMPAATARVAGERVRLQVVHPMPPTPGSMDAWRTELGRLRDAAAGRGDVPTVFGGDFNSSQDHEAFRDILDTGLRDSAMLLGRSRTPTWPASATPLFGAQIDHVLVSDRLSPAGIEFPELAGTDHRAVLVELQLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDR6</accession>
    <name>A0A0F7NDR6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AA958_33675</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="1"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019583.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_33675"/>
    <dbReference type="EnsemblBacteria" id="AKH86361">
        <property type="protein sequence ID" value="AKH86361"/>
        <property type="gene ID" value="AA958_33675"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_33675"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.7110"/>
    <dbReference type="OrthoDB" id="561611at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011708">
        <property type="entry name" value="DNA_pol3_alpha_NTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041931">
        <property type="entry name" value="DNA_pol3_alpha_thumb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040982">
        <property type="entry name" value="DNA_pol3_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029460">
        <property type="entry name" value="DNAPol_HHH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004805">
        <property type="entry name" value="PolC_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32294">
        <property type="entry name" value="PTHR32294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07733">
        <property type="entry name" value="DNA_pol3_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17657">
        <property type="entry name" value="DNA_pol3_finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14579">
        <property type="entry name" value="HHH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00594">
        <property type="entry name" value="polc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="POLIIIAc" evidence="8">
        <location>
            <begin position="7"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH86361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="1180" mass="131293" checksum="03EC06E52DE6C594" modified="2015-07-22" version="1">MAKPPFTHLHVHTQYSLLDGAARLKDMFAACREMGMSHIAMTDHGNLHGAYDFFVQASAAGVTPIIGIEAYVAPESRRNKRKVQWGQPHQKRDDVSGSGGYTHKTIWASSRTGLHNLFRLSSDAYKEGWLQKWPRMDKEVIAEHAEGLIASTGCPSGEVQTRLRLGQFDEALAAAAWYQEVFGKQRYFLELMDHGIEIERRVRDGLLEIGRKLGIPPLVTNDSHYTYAQEAGAHDALLCIQTGKNLSDPDRFRFDGTGYYLKSTEEMYAVDSSDAWQEGCANTLLVAEQIDTSGWFEKRDLMPRFEVPDGYSEVTWFREEVWNGMRRRYPDGWDENYRKQAEYEMDVIVQMGFPGYFLVVADFIMWAKNNGIAVGPGRGSAAGSIVSYAMGITDLDPIEHGLIFERFLNPERVSMPDVDIDFDERRRAEVIRYVTEKYGADKVAMIGTYGTIKAKNAIKDSARVLGYPYAMGDRITKAMPADVGGHGIDLAGITDPAHPRHAEAGEVRSMYENEPDVKKVIDTARGVEGLVRQMGVHAAGVIMSSEPITDHVPVWVRHTDQVTITQWDYPTCESLGLLKMDFLGLRNLTIMDDAVKMVKQNKGRDIELLSLPLDDPRTFELLGRGDTLGVFQFDGSAMRSLLRLMRPDHFEDITAVTALYRPGPMGMNSHINYALRKNGRQEITPIHPDLAEPLKEVLDITYGLVVYQEQVQKAAQVLAGYSLGQADLLRRAMGKKKQEVLDKEFVPFRDGCRQRGYTDEAVQAVWDVLVPFAGYAYNKAHAAAYALVSYWTAYLKANYPAEYMAALLTSVRDDKDKSAVYLNECRKMGIKVLPPDVNESDANFTPRGDDTIVFGLTAVRNVGQNVVESIVRNRKAKGRYASFPDFLDKVDAVVCNKRTVESLIKAGAFDALGHTRKGLTAQYEPMIDNVVSVKRKEAEGQFDLFGGMGDEAAADEPGFGLDVQFTDEEWEKSYLLAQEREMLGLYVSDHPLFGIEHVLGDRADASIAALNGGDHADGAIVTIGGIISGLQRKMTKQGNAWAIATVEDLGGSLDCMFFPATYQLVSTQLVEDAIVFVKGRLDKREDVPRLVAMELAVPDLSTAGERAAVRLDITEAQVTPESVARLKTVLQAHPGPSDVHLRVRGRTRTTVYRLGHRIAPRPEFWADLKAAVAVTREPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NE21</accession>
    <name>A0A0F7NE21_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">4-hydroxybenzoate 3-monooxygenase</fullName>
            <ecNumber evidence="2">1.14.13.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_29240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.14.13.2" evidence="2"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018877.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_29240"/>
    <dbReference type="EnsemblBacteria" id="AKH85648">
        <property type="protein sequence ID" value="AKH85648"/>
        <property type="gene ID" value="AA958_29240"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_29240"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6164"/>
    <dbReference type="OrthoDB" id="1770293at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018659">
        <property type="term" value="F:4-hydroxybenzoate 3-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="4"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="391" mass="43195" checksum="8432CA67DB92D206" modified="2015-07-22" version="1">MHITVGIVGGGPAGLLLARLLRRAGVDCVVLESRDRAYAEQRQRAGILEQSTVDALRSCGAGERLDREGLVHDGIELRFDRRSHRIDFPSLTGGRRVWVYAQTEVVKDLIALQLKDGAPLFFEAEVRAVEGADTDRPTIRYLHRGREQALTCDYVVGCDGFHGVARSAFPDGVQRVYERTYPYSWLGILADVAPSCDELIYAHSPRGFALHSMRSPVVSRLYLQVPNGAEPADWPDERIWDELDARFAVDGDWRLARGPVTAKSVLPMRSHVLEPMRHGRVFLAGDAAHIVPPTGAKGLNLAAADVIVLARAFARLHESGSADLLDAYSDTCLRRVWRAEHFSYFMTTALHADPEQSPFDTRLQLSQLDRIATSPHAAAELAENYAGLPLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NE27</accession>
    <name>A0A0F7NE27_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Terpene synthase</fullName>
            <ecNumber evidence="2">4.2.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_01915</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the terpene synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.-" evidence="2"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_01915"/>
    <dbReference type="EnsemblBacteria" id="AKH86496">
        <property type="protein sequence ID" value="AKH86496"/>
        <property type="gene ID" value="AA958_01915"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_01915"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.414"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034686">
        <property type="entry name" value="Terpene_cyclase-like_2"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01020">
        <property type="entry name" value="Terpene_Cyclase_Like_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU366034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH86496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="741" mass="81868" checksum="3661F1F48D7A499E" modified="2015-07-22" version="1">MPPEQPFELPTFYLPWPARLNPHVEQARGHSRAWARGMGMLEGSGIWDTADLDAHDYALLCAYTHPECSADVLSLVTDWYVWVFFFDDHFVEAFKRDRDRAGAKAYLDRLPAFMPLEPHGADMPEPRNPVEAGLADLWARTVPAMSADWRRRFARSTVNLLDESLWELANIDEGRVANPVEYVEMRRKVGGAPWSAGLVEYAAPAEVPDRVAASRPLLVLRDTFSDAVHLRNDLFSYQREVEEEGELSNGVLVMETFLGCDTQEAAEHVNDLLTSRVQQFEHTALTELPLLFAEEELTPDECARVVAYAKGLQDWQSGGHEWHLRSSRYMNEGAAAAGPPALPYAPAGPGADVRGLFTATGATRLRPYTHVPYRRVGPSLVPELPMPYGLRLSPHLDAARIRTAGWARRMGFLQPQPGVPGSHVWDGPRLRGYDLPLCAAGLHPDADGEELDLSSRWLAWGTYGDDYYPAVFGRTGDLAGARASNDRLKLCMPLADGAPVAPPANALERGLADLWRRTAGPMPPEERARFRATVDVMLDAWLWELSNRAQNRIPDPVDYIEMRRATFGSAMTMYLCRLRRGTAVPAEVYESGPVRALENSAVDYACLLNDLFSYQKEIEYEGDLHNGVLVVENFFGVGYPAAVRIVHDLVAGRMREFEHVVAAGLPVLYADLEASEEVRAAVAGYVRDLQNWMAGILNWHLHVRRYGAAELAEDACGPGLPGGAPAGLGTAAARPGAWAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NE61</accession>
    <name>A0A0F7NE61_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SseB_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_25405</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_25405"/>
    <dbReference type="EnsemblBacteria" id="AKH84997">
        <property type="protein sequence ID" value="AKH84997"/>
        <property type="gene ID" value="AA958_25405"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_25405"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5355"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027945">
        <property type="entry name" value="SseB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14581">
        <property type="entry name" value="SseB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SseB_C" evidence="2">
        <location>
            <begin position="137"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH84997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="279" mass="29024" checksum="C9C7DE9BF5377D36" modified="2015-07-22" version="1">MNGGASGRAPGAGVDQLVRQVAPGRYDAYEALLAALAAGQVWMLLWQGRPDSPDAQYGSMQIEGHAYAPCFSSDRELAASGWAGAHEPVAGAEIAAALYPDRWGLWLDPHAAGGGVGVPWLDLRRVATGLDRLPAGPLRIAEPVVDVAQFYALLGQTAHRTPAVRTLCRAWVQPVLGEPYLAIGIDLYDTGAQSVAAAQSMMQESVAAVPPGLAVSTVALADDHDPVAMWMRANSRPFFDRGAYGGGPAAPPAGYGYPPPHSAGGAPQSGWQPGPAPQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NEC9</accession>
    <name>A0A0F7NEC9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Family 31 glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_29705</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018941.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_29705"/>
    <dbReference type="EnsemblBacteria" id="AKH85713">
        <property type="protein sequence ID" value="AKH85713"/>
        <property type="gene ID" value="AA958_29705"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_29705"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6271"/>
    <dbReference type="OrthoDB" id="469334at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH85713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="675" mass="74330" checksum="A67F946E49FC1290" modified="2015-07-22" version="1">MVSFRPTRTALEIRHRHEVLTVQAWGADSVRVRAAPFRLPAESHGALGEPPPSPAPPRITVDGDRAVLVHGELTVTAAFDRRAAYPEPLLAFSRTSTGAELLAESREHFWLPGARVFRGDGTGAYEVRQRFTAYTGERLYGMGQRTHGRLDLKGLALDLVHRNGEVSIPFVLSSRGYGLLWNLPAVGRAEFAENGTRWQAGRAREIDYWLTAAPTPAGILARYADATGHAPELPCWASGFWQSKLRYRDQDELLAVAREHRRRGLPLSVIVADYFHWPAMGDHRFDPAEWPEPRAMVEELAEQGVELMVSVWPTVSPLAESWPDYRDRGLLAGTAQGVEFHQTIQDKGMAVPMPVAFYDPTNPETRAYVWERIRRGYRDAGIRVFWLDACEPELNPAQPENLALYAGPGAEVAGVYPRDNARLFAEGMAADGAGPTVLLCRSAWAGAQKYGAALWSGDIPATWESLRRQIRAGLSVAVSGIPWWTTDIGGFHGGDARDPAYRELMIRWFQFGVFCPLFRLHGDREPRTPTSYAQTGGPNEVWSYGDEAYGIIAGLLHLRERLRPYLHEQMTTAARTGLPPMRPLFLDHPGDPCTWTVDDAFLFGPDVLVAPVAEAGQRAREVYLPAGARWVCAATGRTYDGGSAVTAAAPLDRIPVFTREGADVPLGVTGAAATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NEI2</accession>
    <name>A0A0F7NEI2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_30600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019072.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_30600"/>
    <dbReference type="EnsemblBacteria" id="AKH85844">
        <property type="protein sequence ID" value="AKH85844"/>
        <property type="gene ID" value="AA958_30600"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_30600"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6467"/>
    <dbReference type="OrthoDB" id="1762546at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014338">
        <property type="entry name" value="CHP02996_rpt-companion-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02996">
        <property type="entry name" value="rpt_mate_G_obs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH85844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="317" mass="34217" checksum="A921B3AE9A3E6943" modified="2015-07-22" version="1">MTLGALERTLRERPDDLASWLVYGDRLQERGDPRAELIRLAERRARVAPGSRRKAVEREIDALVAEHRESWDAELPEGVSARERRHGFATAIAVEWDDDAPMLIEQALRVAPFATTLKIVPPESDPAEFDYWDDDTDEDGEPLPSAEVEAGTLATLDLAAFTSVDLSYLRVGALGAKALAVSSYFRAEAAGGRTLAAPAAPGRIGALDLRYCHVGDSGLAALAANPFFTGARRLHLQHNALTAKGVRALHAFGDLTELDLRYNAIGEEGAEALLAAPFLGSLTRLLLYAADVGEAGARRLAAASALPPVLRSYWRSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NEP9</accession>
    <name>A0A0F7NEP9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_31070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019147.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_31070"/>
    <dbReference type="EnsemblBacteria" id="AKH85919">
        <property type="protein sequence ID" value="AKH85919"/>
        <property type="gene ID" value="AA958_31070"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_31070"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6566"/>
    <dbReference type="OrthoDB" id="1850835at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH85919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="71" mass="7719" checksum="58E110E19E894572" modified="2015-07-22" version="1">MADDDSADALAAVAALRRLADRLEDAAVERAMRTGWSWPQVAEALGVTRQAVHKKHAKRLIAAGVTLRRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NES1</accession>
    <name>A0A0F7NES1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NMT1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_31245</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019177.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_31245"/>
    <dbReference type="EnsemblBacteria" id="AKH85949">
        <property type="protein sequence ID" value="AKH85949"/>
        <property type="gene ID" value="AA958_31245"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_31245"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6602"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027939">
        <property type="entry name" value="NMT1/THI5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015168">
        <property type="entry name" value="SsuA/THI5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31528">
        <property type="entry name" value="PTHR31528"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09084">
        <property type="entry name" value="NMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519417" description="NMT1 domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="NMT1" evidence="2">
        <location>
            <begin position="58"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH85949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="368" mass="38699" checksum="713726604530CDB6" modified="2015-07-22" version="1">MFPSGKKIRKSRKTVAGIAGATTAALLLAACGGDSGGDSADGGLDKVTIQLDYQLRGNHGMFYVADKLGYFKDEGIDVDTIKTGTGSPDALRIVGTGGADFGFADLPSLVTARSQEVPVTTLAAVNQTSPLAMCTVKDENKLTSIDDLKGMTVGIHAAGSTFLFYQALLGDNGLDRGDLKEVSVTPPYENYLIQGKVDTVPCYIDAEVPQLEDAAGGEGSLDVLLGSDYGYEAYGSGLFTSDDMVKNDPGLVQRFTNAYIKAFGYVMENPDKTAQILAESSPETRDKADLFERQIQADIDHTFTSAVTEKHGLGAMDKQAWQATIDALADQDVLKGSPPSVADVHQEKFVEKAAKTGAGSGAGNDAGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NEV5</accession>
    <name>A0A0F7NEV5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_26870</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_26870"/>
    <dbReference type="EnsemblBacteria" id="AKH85257">
        <property type="protein sequence ID" value="AKH85257"/>
        <property type="gene ID" value="AA958_26870"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_26870"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5652"/>
    <dbReference type="OrthoDB" id="1077305at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <location>
            <begin position="193"/>
            <end position="372"/>
        </location>
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        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH85257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="462" mass="48397" checksum="E467E82BA50C4571" modified="2015-07-22" version="1">MTAETTSTMTFHPRPQGGEARPWAFPAPERTTLANGLTVLTCHRPGQQVVAVEVCLAAPLDAEPAGLDGVAMIMARAFSEGTDTHTAEEFAAELERSGATIDAHADHPGVRVSLEVPVSRLRRGLGLLADALRAPAFPDDEIERLVANRLDEIPHELANPGRRAAMALYAELFDAGDRLSRPRWGTEESVARIDAASVRAFYSAHVRPATATVVVVGDLTGVDVGAALAGSLGAWTGTPAEARPLPPVAADDTGRVVIVDRPGAVQTQMLVGRVGADRHDAVWPAQLLGTYCLGGTLTSRLDVVLREEKGYTYGVRASAQSLRSPADGTGAALLAIGGSVETDVTGPALADSWQVLRSLADGLTDAERDAAADFLVGVAPLRYETSAAVAGTLADQVEQQLPDDYQAKQYARLADTGTVEATAAVLSAFPTDRLVTVLVGDAEKIAEPVRELGIGEVRVVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFE8</accession>
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            <fullName evidence="3">Ribonuclease</fullName>
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    </protein>
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        <name evidence="3" type="ORF">AA958_32680</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86189.1"/>
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    </dbReference>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Endonuclease-I"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Endonuclease_1"/>
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        <property type="match status" value="1"/>
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        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
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            <end position="271"/>
        </location>
    </feature>
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        <location>
            <begin position="127"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH86189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="271" mass="29631" checksum="270AB8A19DFE34E4" modified="2015-07-22" version="1">MDTSRIPRTALISAVALAAAATGTLPSVAATPAEPATSSVVAYDDTYYKDALGKEGDELKSALHTIISDQTKISYSQVWEALMETDEDPANPDNVILLYSGVSQSKDSNGGNADDWNREHVWAKSHGDFGTSTGPGTDVHHLRPTDVTVNSTRGNKDFDYGGSPVDQAPGSFTDDDSFEPRDDVKGDVARMILYMAVRYEGNDGFADLEPNDQVNNGSSPAIGKLSVLKEWNDQDPPSDFEKNRNQVIFDQIQHNRNPFIDHPEWVDSIWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFL2</accession>
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            <fullName evidence="4">Alkaline phosphatase</fullName>
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        <name evidence="4" type="ORF">AA958_32290</name>
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    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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        </lineage>
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    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_32290"/>
    <dbReference type="EnsemblBacteria" id="AKH86128">
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        <property type="gene ID" value="AA958_32290"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_32290"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6817"/>
    <dbReference type="OrthoDB" id="165142at2"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
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        <property type="entry name" value="PhoD-like_MPP"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="TAT_signal"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002520050" evidence="1">
        <location>
            <begin position="36"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="domain" description="PhoD_N" evidence="3">
        <location>
            <begin position="51"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="PhoD" evidence="2">
        <location>
            <begin position="162"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH86128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="534" mass="58535" checksum="5256AF7D31572315" modified="2015-07-22" version="1">MSRFTSTPGFSRRRFLALGSGFSLAAALPVAGLSAAPARAEPRFSGDPFALGVASGDPEPDGAVLWTRLAPDPLAADGRGGMPGYKVPVTWQIAEDPGFRRVRRAGVEWAVPELGHSVHAEVRGLEPDREYWYRFRAGRHVSEAGRTRTAPAADAGIASMAFAFVSCQNYPDGHFTAFRHLAGEDVDVVVHLGDYIYEGGGQGTVGRGHLPAREIHSLADYRVRYGQYKLDPDLQAEHAAHPWIVVLDDHEVDNNWADGLDGDDVGGAEFAARRAAAFQAYYENLPLRRSSLPAGPHMQLYRRLSYGTLAQFHVVDTRQFRDNQACGDGRQFDCDDRLDPARTMLGAEQEAWLLDGLTRSRTTWDVMANQIMTMQGDSAEGIEQAFGMDTWDGYAAARQRLFDGVEKRGIGNFVVVTGDAHRSVAADLKHDFDDPASATVGVEFLGTSVSSGGNGSDQDEWGRIWLQENPHMKFHNVQRGYGVCEVTRESWRTDYRVVPYVSTPGAPVATRARVHVTAGRPGIREVEQLAVPQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFN6</accession>
    <name>A0A0F7NFN6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">L-lactate permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AA958_29340</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Transports L-lactate across the membrane. Can also transport D-lactate and glycolate.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the lactate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020507.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_29340"/>
    <dbReference type="EnsemblBacteria" id="AKH87111">
        <property type="protein sequence ID" value="AKH87111"/>
        <property type="gene ID" value="AA958_29340"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_29340"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6189"/>
    <dbReference type="OrthoDB" id="732251at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015129">
        <property type="term" value="F:lactate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003804">
        <property type="entry name" value="Lactate_perm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30003">
        <property type="entry name" value="PTHR30003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02652">
        <property type="entry name" value="Lactate_perm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00795">
        <property type="entry name" value="lctP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="236"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="265"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="323"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="373"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="405"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="460"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="540"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="564"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH87111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="596" mass="62643" checksum="7D9B901FEA3782FF" modified="2015-07-22" version="1">MLTGNLAVLSLLALAPILLVGVLLVGLRWPATYAMPAGYALVVVIAMVAWEVGATEVVASSVQGLIIALTLLYIVFGALLLLATLDASGALRTIRSAFTQISPDRRVQAIIVGWLFGSFIEGASGFGTPAAVVAPLLLALGFPAMAAVMVGLIIQSTPVSFGAVGTPMLVGVNNGLSGSPAVEAHLEREGTVLADYVPEVAVQVALLHAIIGTLVPLFVVCLLTRYFGTRRSFGEGLAIAPFALFAALAMTVPYVAVAVLFGPEFPSLLGGLVGLFIVMIATRRGFLQPARPWDFPPRERWLPEWTGTVQPDMREATATDMPVARAWLPYLVVASLLVLTRLPQLPLKEWLSGMSIEWNGILGTGVSQAVEPLFLPGFMFLATIGFTYVVFRMKRREIAESWRVAGRQIVAAGVALLFAVPLVRVFINSGPDFNTTGLDSMPLTLATGAADLAGSAWPMFAPWVGALGAFVAGSNTVSNLMFSLFQFSTAEQIDVSPTVVVATQAVGGAAGNMVTVHNVVAACATVGLIGKEGHLIRKTVLPMIYYCVAAGMLSYVFIHGLGLNAGTLGLALLLAFLTALAVYARRRVPADGPADG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-10-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFP6</accession>
    <name>A0A0F7NFP6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_32395</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019370.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86143">
        <property type="protein sequence ID" value="AKH86143"/>
        <property type="gene ID" value="AA958_32395"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_32395"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6838"/>
    <dbReference type="OrthoDB" id="1253790at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041273">
        <property type="entry name" value="DUF5596"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041644">
        <property type="entry name" value="GNAT_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18164">
        <property type="entry name" value="GNAT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18082">
        <property type="entry name" value="NAT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAT_N" evidence="1">
        <location>
            <begin position="43"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="GNAT_C" evidence="2">
        <location>
            <begin position="180"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH86143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="348" mass="37152" checksum="78F12BD4228DCFB0" modified="2015-07-22" version="1">MTDLNAAAVRDQLGLDGTYTPWTDALASAHPAPPPADVPRGAELTALLRAVGVPEREDAELTATLAEVTAAGSPYAWLLDRAVAAMAAAMGSVGDDRGGPGSGPALPAALGAAGRWFHTAVFLAAVPEVRAYHARRDVPDDVSRATLADLGNKVGVHRRLHGEGGMGNQRWMTLPYGGILYRLGRLQFNLDRDPDAGHGLEVHVPEGGPLDPRACEESYARAAEFFPPRFGTFLKSAPGGELRLNCASWLLDPQLGDYLPADSNIMRFQRRFTLDPREPARVPEPDEHGLAVPDRGIVEFVFRRVVRTPADVAALPARTTLERAVVAHIADGGHWGAPRGSFMLPVPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFS9</accession>
    <name>A0A0F7NFS9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_30830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020582.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_30830"/>
    <dbReference type="EnsemblBacteria" id="AKH87156">
        <property type="protein sequence ID" value="AKH87156"/>
        <property type="gene ID" value="AA958_30830"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_30830"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6516"/>
    <dbReference type="OrthoDB" id="1795011at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH87156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="154" mass="16320" checksum="6D38D8918FC38E6E" modified="2015-07-22" version="1">MHMTTSAAVTLADLTARTGLDVLAHLEREVTIPVVAGLQAQGDLIVVPLALLDDVTVPPHTRWTAVPAGGVELLRGAAGGNPHTLVADPGTCRWSRRVQDPQRLALGVLDATAVAYLIHPEHGGTGIAPGTYVIRRQRERSESTGRLGNRFIAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFY7</accession>
    <name>A0A0F7NFY7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH luxR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_33025</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86243">
        <property type="protein sequence ID" value="AKH86243"/>
        <property type="gene ID" value="AA958_33025"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_33025"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6977"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="230"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="171"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="210"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH86243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="292" mass="30663" checksum="99CDE476D4A94D6E" modified="2015-07-22" version="1">MWLAELSGLRDPELLLTSLAAVLELPEQPGMGTLDAMVAHLRERRLLIVLDTCEHLLDACAMLSDVLLREAPGVSVLATSRQPLDVPGERCLTTAPLGPADSLELFVQRAASVAPGFAVTDANREQLLALAHLVGPADGGTERLVPDVGGAPAAGQHLEAAVAPVGQLRERHRPQPHRGQLQHQRHAVEPADDGARMPGAAVLAAVRTDADEPPGGAAAPAATALPEADGRSAAPALTRREREVAALVAQGLSNREAAERLVISKRTADAHVEHIFAKPGITSRRETPAVLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NGA8</accession>
    <name>A0A0F7NGA8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_01430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86484">
        <property type="protein sequence ID" value="AKH86484"/>
        <property type="gene ID" value="AA958_01430"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_01430"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.315"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13577">
        <property type="entry name" value="SnoaL_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="2"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="141" mass="15245" checksum="29E34D3F7976FBE3" modified="2015-07-22" version="1">MDRLDVIDTCTRMAWYADQRDGDRLAGVFADNVTLDYTSLDGGEPAVMTPGQIADGWRELLGAYETTQHLLGNHLVTVTGASAVCTASFQATHRRAEAYGGSLWTLGGTYRFDLVRTAGGWRISGIVMTALWGDGNRGLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NGF5</accession>
    <name>A0A0F7NGF5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Universal stress protein UspA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_02675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_02675"/>
    <dbReference type="EnsemblBacteria" id="AKH86514">
        <property type="protein sequence ID" value="AKH86514"/>
        <property type="gene ID" value="AA958_02675"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_02675"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.571"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="1">
        <location>
            <begin position="2"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="136" mass="14070" checksum="AD058CB812210722" modified="2015-07-22" version="1">MILVGVDGSDTSWRAAAYAAGLARRQGSLLAVVYVQPTLAAAAALGAPVAGTTAEVAEELVAEIRQAVAQLRGLFDVRWEFHTLHGDAYTGLVQAAQDLTADAVIVGASEQAGHRLVGSVAVRLVKAGRWPVTVVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NGQ0</accession>
    <name>A0A0F7NGQ0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1990 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_01105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019693.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_01105"/>
    <dbReference type="EnsemblBacteria" id="AKH86473">
        <property type="protein sequence ID" value="AKH86473"/>
        <property type="gene ID" value="AA958_01105"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_01105"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.244"/>
    <dbReference type="OrthoDB" id="1586328at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018960">
        <property type="entry name" value="DUF1990"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014457">
        <property type="entry name" value="UCP010260"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09348">
        <property type="entry name" value="DUF1990"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010260">
        <property type="entry name" value="UCP010260"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1990" evidence="1">
        <location>
            <begin position="5"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="169" mass="18164" checksum="2DDBA4C5DD1E6523" modified="2015-07-22" version="1">MDDLTYAPVGATREGRSPAGFDSFAVRTRIGAGPAAYRAATEAVLTFRMHRAVGVTIDAEGPRAAPGVQLVVGLGRRPLRILAPCRVVWAERGERRGGFGYGTLPGHPETGEEAFVVEWADDGAVWLTVTAYSRPAARWVATMGPLLGVFQRGYARRCGRVLRRLANVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NGQ4</accession>
    <name>A0A0F7NGQ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_01220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019699.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86478">
        <property type="protein sequence ID" value="AKH86478"/>
        <property type="gene ID" value="AA958_01220"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_01220"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.268"/>
    <dbReference type="OrthoDB" id="1465613at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="2"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="300" mass="32649" checksum="17F6DE07626C230D" modified="2015-07-22" version="1">MKAGVIGLGDIARKAYLPVLASLPGVEPHLLTRTPATLDRVGDAHRIPHAHRHRDLGSLLAAGLDAAFVHAPTEAHVELATALLEAGIPVYVDKPLAYDLAGAEGLTRLAEERGVSLMTGFNRRHAPGYAQCLEHPRELIILQKHRVGLPEDPRTMVFDDFIHVVDTLRFLAPGPVEQADVRARVRDGLLHHVVLQLSGDGFTAIGAMNRLSGSAEEILEVSGQDTKREVRNLAEVVDHKGQPSVRRRGDWVPVARQRGIEQVVLVFLDAVRAGEVLSARDALATHELCERIVREVGRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NGT1</accession>
    <name>A0A0F7NGT1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Gamma-glutamyl phosphate reductase</fullName>
            <shortName evidence="7">GPR</shortName>
            <ecNumber evidence="7">1.2.1.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Glutamate-5-semialdehyde dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Glutamyl-gamma-semialdehyde dehydrogenase</fullName>
            <shortName evidence="7">GSA dehydrogenase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">proA</name>
        <name evidence="9" type="ORF">AA958_09505</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>L-glutamate 5-semialdehyde + NADP(+) + phosphate = H(+) + L-glutamyl 5-phosphate + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19541"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="ChEBI" id="CHEBI:58274"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the gamma-glutamyl phosphate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.41" evidence="7"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019908.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_09505"/>
    <dbReference type="EnsemblBacteria" id="AKH86644">
        <property type="protein sequence ID" value="AKH86644"/>
        <property type="gene ID" value="AA958_09505"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_09505"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2004"/>
    <dbReference type="OrthoDB" id="223669at2"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004350">
        <property type="term" value="F:glutamate-5-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07079">
        <property type="entry name" value="ALDH_F18-19_ProA-GPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00412">
        <property type="entry name" value="ProA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012134">
        <property type="entry name" value="Glu-5-SA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000965">
        <property type="entry name" value="GPR_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000151">
        <property type="entry name" value="GPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00407">
        <property type="entry name" value="proA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0521">NADP</keyword>
    <keyword evidence="6 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 7" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="8">
        <location>
            <begin position="3"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH86644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="425" mass="44239" checksum="5294862B4887B7A3" modified="2015-07-22" version="1">MSSETQSPVRQAAQRARTAAAMIAPLPRAAKDAALLAVADALQARAAEIVAANAEDVARARADGVSDAIVDRLTLTEERVAGIASDVRDVAKLPDPVGEVVRGSTLPNGLELRQVRVPLGVVGIIYEGRPNVTVDAAALCLKSGNAVLLRGSSSAYASNTALVAVLRDAVASAGLPPDAVQLVPGQGRESVHELMRARGLVDVLIPRGGAGLIRTVVEESTVPVIETGTGNCHVYVDEHADLDLAEKILVNSKAQRPSVCNAAETVLVHQAVADAFLPRALRALEAAGVTVHGDDAWVKAGAAAGVEVRLADDEDWATEYLSYDIAAAVVRSLDDAVAHIRRWSSGHTEAVVTRDTGAARRFTALVDSAAVMVNASTRFTDGAEFGFGAEIGISTQKLHARGPMGLPELTSTKYVVTGDGQLKGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NGZ1</accession>
    <name>A0A0F7NGZ1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tricorn protease homolog</fullName>
            <ecNumber evidence="7">3.4.21.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AA958_12170</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Degrades oligopeptides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the peptidase S41B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="7"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_12170"/>
    <dbReference type="EnsemblBacteria" id="AKH86704">
        <property type="protein sequence ID" value="AKH86704"/>
        <property type="gene ID" value="AA958_12170"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_12170"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2560"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="PD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005151">
        <property type="entry name" value="Tail-specific_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028204">
        <property type="entry name" value="Tricorn_C1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029414">
        <property type="entry name" value="Tricorn_PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012393">
        <property type="entry name" value="Tricorn_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43253">
        <property type="entry name" value="PTHR43253"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03572">
        <property type="entry name" value="Peptidase_S41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14684">
        <property type="entry name" value="Tricorn_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14685">
        <property type="entry name" value="Tricorn_PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036421">
        <property type="entry name" value="Tricorn_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00245">
        <property type="entry name" value="TSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="TSPc" evidence="11">
        <location>
            <begin position="883"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1106"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="781"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="1006"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="1064"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer; via amide nitrogen" evidence="9">
        <location>
            <position position="1007"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR036421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR036421-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR036421-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AKH86704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="1129" mass="122045" checksum="187269BB464CBE6A" modified="2015-07-22" version="1">MPYLRFPHLHGDLLCFAAEDDLWLAPLPAPGAKPERGWRLTVDRTRVGHPRFSPDGRSIAFTSWHSLDAEIHVVSAEGGVARRLTYWGSPDTRVCGWTPPGSGEDGEAQILAVSSQGQPLSYQTWSYLVPTDGSPGRRLPWGPVDDIAVAEQAGHRKTLLLTGRPPHEPAAWKRYRGGATGRIYLHGRRLLADLGGHVECVMFVGPPPAARIAFLSDHEGVGNLYSCLPDGTDLRRHSDHAEFYARNAATDGYRVIYQCAGELWLAEDFGPAGQPRRLDVRLGSPRAGRRPYQVAAQNNVQGLTVDTTGRASAVAVRGALYWLTHRDGPARTITETPGVRIRLPEMLGDTNRVAYVTDAAGEDAIEIADLPRTGAVGEPLRLAAGKLGRVLALVPSPDGRHIALASHDGRLLLVRVPERVHVDERMSAEVAEEFAEAVRAAEELSPAEAAGDCQLTELIRSVNGPVRDLAFSPDSKWIAWAHPGIGRSLRQIKIARVADRTIVDVTDGRFEDEEPVFTRDGRYLAFLSWRGFDPVYDVHTGDLSFPLGSRPYLVPLHPATPSPFALSAEGRPAAGGMDPVGPPAAEAGANTAVLVEPEGLESRVTPIPVPASKYSSLVPVAGGGLVWLRWPISGALGETFANPADTSGRPTLEHFDISTARLTELTSLVTEIAVSGDGSRLVVNDGGSLRAIPANGLADADTTVYIDMRRVLHTADPVAEWHQAYDEAGRVIRAYFWEPRMCGVDWDAVLAQYRPLLDRVASPDEFADLLREVLGELGTSHAYVTPARRNEGPPHYQRPIGFLGVNFVRTRDGRGWALARILPGDSSDTRARSPLAGTGIPDGSVLTHVDGRAVDPVTGPYPLLEGAGGTSVELTFAIEGGGGRLRRVAVVPLVDDRPLRYQDWVAARRAVVHELSGGRCGYLHIPDMIGSGWAQFNRDVRMEMNREALIVDVRGNAGGHISELVLEKLTRTIMGWDLTRNAQPVSYTSTAPRGPMVALADEATSSDGDMITAAFKLLGLGPVVGLRTWGGVVGMTGRHRLGEGTVITVPMNAAWFDEYGWGVENAGVPPDVVAERTPLDWAEGRTSELNVAVATALDLLREHPAAVPPDYTDVPDRSRPPLPPRTRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NH36</accession>
    <name>A0A0F7NH36_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_08330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019865.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_08330"/>
    <dbReference type="EnsemblBacteria" id="AKH86613">
        <property type="protein sequence ID" value="AKH86613"/>
        <property type="gene ID" value="AA958_08330"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_08330"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1757"/>
    <dbReference type="OrthoDB" id="447734at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH86613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="407" mass="44107" checksum="A8B1B3DFA3ED24EF" modified="2015-07-22" version="1">MVLGLAACGDDGGSSDGTTTIKLVAADYGDKASNASKVYWDDVVKRFEAKNKDIRVDVQVINWNDIDTKVKTMIQGGNVPDVLQTGGYADKVADDLLYEADEVLSPKTKSNLIESFAKAGEVDGTQYGIPFVSSARLMFYNKDVLDAAGVEVPRTWDDVAAAAEKIKDEKAAEIPYALPLGPEETQGESMIWEIGNGGGYTDAEGNYTIDSAQNVETFEWLKENLVDPGLTYENPATTDRKTAFADFAAGKVGMLNGHPTLIQMAKDGGVDYEVAPIPGKDGPLDSTLGVADWMMAFKDGGKQEEIRKFLDFAYAKENTLKFDEMYNLMPVTTDTLEEMQSSGKHKDLEPFFEVLPAAQFYPLGSTSWDVVSAEIKKSGGKAVSDDPSKVLGELQQKAEETAADMGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NH79</accession>
    <name>A0A0F7NH79_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_31975</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019300.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_31975"/>
    <dbReference type="EnsemblBacteria" id="AKH86072">
        <property type="protein sequence ID" value="AKH86072"/>
        <property type="gene ID" value="AA958_31975"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_31975"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6752"/>
    <dbReference type="OrthoDB" id="1559817at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519495" evidence="2">
        <location>
            <begin position="30"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH86072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="344" mass="37274" checksum="C8E27D1E70EE11B4" modified="2015-07-22" version="1">MGTKKTAVSTAAAGLTALLLATGCSGGSDDDGGGAGDEKAQPRPVISEGQARKVLERYVETNNAANAALDRKALGEVEGGALYQQSQAQYRQFPTYEKKYQALYKKPFRYRADEAQYYIPARGDWYMVDAPVEGPGYDEGDRSLLVFERAGGGTWKNVASVGIQGRIPEVARGDGGLPTVLPAGTEVGTTALDGLDDAVNDLYVSGGKKDGKLLADSEVRKNMVKDHATRRDWIRPEHDGYFETEFESENHKWDDAYKPAFPDVYALRTADGGALTVFNSYDARVDFATRPGFHVIPGDATSLYVKEKEPLGVREYYAVQNAAHVPEEGKVEQLGGEVEMIGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NH84</accession>
    <name>A0A0F7NH84_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_32000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019305.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86077">
        <property type="protein sequence ID" value="AKH86077"/>
        <property type="gene ID" value="AA958_32000"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_32000"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6757"/>
    <dbReference type="OrthoDB" id="1956942at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH86077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="161" mass="16326" checksum="47E5634F89FF0CDF" modified="2015-07-22" version="1">MDATALARSLLEPVPAHRTAGLTVLRAIDGAAEVAVEAPGVLGNVIGSLHSSGLATLVDAAALAAILSAGDAPGELDGVLPLGASASFEYLAPARGRLIASCKLSSSAVQVLRPVLAGTADRARISTQGVVTDERHAVVCRGGFEWSVRRVTRTARIRPGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NIC1</accession>
    <name>A0A0F7NIC1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycosyl hydrolase family 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_02615</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019736.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_02615"/>
    <dbReference type="EnsemblBacteria" id="AKH86512">
        <property type="protein sequence ID" value="AKH86512"/>
        <property type="gene ID" value="AA958_02615"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_02615"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.559"/>
    <dbReference type="OrthoDB" id="1832114at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006103">
        <property type="entry name" value="Glyco_hydro_2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Glyco_hydro_2_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006104">
        <property type="entry name" value="Glyco_hydro_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037524">
        <property type="entry name" value="PA14/GLEYA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011658">
        <property type="entry name" value="PA14_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02836">
        <property type="entry name" value="Glyco_hydro_2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02837">
        <property type="entry name" value="Glyco_hydro_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07691">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00758">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="SSF49303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51820">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PA14" evidence="5">
        <location>
            <begin position="28"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="517"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH86512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="861" mass="94446" checksum="06BEE780D329D6D5" modified="2015-07-22" version="1">MVPAGPGFSATSADRPAAAEAADSRAAAEVHGLKGEYYTHSAPGAFDFDQLKATAFDPSLDFDNLEPRLAARAGQADHVSVRWTGGITPEVSGAHTFHVSADNGFRLWVDGEIVIDHWIDDWDKEQTSQPVTLEAGRTYDIKVEYFEHYGGSNFHLRWTKPGVQKEAVPQSAFTLPADFDYTGPTDVAVQPDGRTLTMDFAQPLTAPPATFDEHLETVIGGADWPRAAAELDPDDPSRLIVPLDEPVVGQGGSADVRYDGEGGLTGADGSDIGEFWTSGANDSEYQLRTKWADDVDEDAPLPEYPRPQLTREDWQSLNGTWQFAGATEGESPPFGRTLDEKIVVPYPVESELSGVQRHEERMWYKRTFTVPRDWGVGQHGERLQLNFDAVDWKADVWLNGKQVASHKGGYDRFSADVTQALRGSGKQELIVGVYDPTDSADGENPPMGKQRLSPSGIWYTSSSGIWQSVWMEPVPTDRAEDLKITPDVAGEQAAVQVRGVRDGVPVTATAYDGRREVGTATGKTGEPLTVPVPDPKLWSPDDPHLYDLKVTVGRGPSADQVRGYFGMRTVGVETIDGQQRMTLNGEPVFAMATLDQGFWPEGIHTAPTDKALKYDLEMHKEMGFNSVRKHIKVEPDRWFYHADKLGLLVWQDMPSMNTKTPSQDSRTQFEHELKEMIEQHDSHPSVVMWVTFNEGWGQYDQARIADYAKELDPARLVNNMSGHNCCGAVDGGNGDISDAHGYPSAQLPNPDGTRALVSGEYGGLGLAIPGHAWPVRHTYVGVDREAYTEEYLIKLAEVERFAACNGSSGAVYTQITDVEGELNGLLTYDRKVLKPDVERIRAAHEALIEGAADGTLTCDAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NII9</accession>
    <name>A0A0F7NII9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_06845</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019834.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_06845"/>
    <dbReference type="EnsemblBacteria" id="AKH86587">
        <property type="protein sequence ID" value="AKH86587"/>
        <property type="gene ID" value="AA958_06845"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_06845"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1431"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16913">
        <property type="entry name" value="YkuD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041280">
        <property type="entry name" value="Big_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005490">
        <property type="entry name" value="LD_TPept_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038063">
        <property type="entry name" value="Transpep_catalytic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17964">
        <property type="entry name" value="Big_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03734">
        <property type="entry name" value="YkuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141523">
        <property type="entry name" value="SSF141523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002520124" evidence="5">
        <location>
            <begin position="29"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="Big_10" evidence="7">
        <location>
            <begin position="58"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="YkuD" evidence="6">
        <location>
            <begin position="247"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="397"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH86587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="417" mass="44564" checksum="666E633EA131D49F" modified="2015-07-22" version="1">MSQTPHRRTAVSCSLLVVALAPGLAACGAGGHPLAREPGEPAGRIALSGVADDSGLADPSEDLEVTAQGQARITDVTAVDESGRYVRGRLSADGHTWRSTVPLAARSRYSVEVSTENDDGAPGRKRLTYRTSKVRTKKPMKVELGPGKGTYGVGQPLTVKLNRAVKTQAERSVVERGLKVSSTPVVQGAWYWVGDKELHYRPKEYWPAGARVRLESRLEGVKVREGVYASAAKPLELKIGDRIEAVTDASAHEMTVYRNGKEINTIPVTTGKAGFETRNGKKVVLEKQSSVRMTGASIGVGGTGEDYDLQVSWATRVTWSGEYVHAAPWSVGSQGSANVSHGCTGMSTEDAAWFFKTVRPGDIVEVVNSYGEDMAPFGNGFGDWNLSWTKWQEGSALTPGVRDGGGPAEAGRLRPGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MXC4</accession>
    <name>A0A0F7MXC4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amidohydro-rel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_00410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH80880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014246.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_00410"/>
    <dbReference type="EnsemblBacteria" id="AKH80880">
        <property type="protein sequence ID" value="AKH80880"/>
        <property type="gene ID" value="AA958_00410"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_00410"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.97"/>
    <dbReference type="OrthoDB" id="1592010at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="1">
        <location>
            <begin position="71"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH80880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="440" mass="45922" checksum="A980050D9A3D4B75" modified="2015-07-22" version="1">MTADNGPAGPVNGPTDIGTWALTGVTALLGEELTPTRQATLVITDGRITAAGRLHDPGPAVPRLHRPDLLITPGFVNGHTHIGDAAFAEAGFRTEGVDLLYAPDGQRWQLMAQAGDEQLVTGMRQAMQTMIRCGVVAFEDFREQGRHGVDLLREATSGLPIRALALGRHADLPFTTEQLRANTGGLSEEAQAEIRDILDSADGFSVVSPNQLTDAALAQTADLVRASGKRLAAHVSEREEDRQTSLARTGRSDIARAIEILRPDYLVHATAATPEELHAAARAGMAVVMCPRSHAALGFGVPPYLGAVAAGVKVALGTDNVMTTTPSPHEEANFLVKAERWRTGTVRHPDPGRLLAAMTVNAAQVLGATDLGSLSVGKAATFVAFDTASPNLAAAAAHDPAAALVNRATAGDIAAVVFDGRTVVGTLDHPTPPATRPGPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MZ13</accession>
    <name>A0A0F7MZ13_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_04160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014875.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_04160"/>
    <dbReference type="EnsemblBacteria" id="AKH81520">
        <property type="protein sequence ID" value="AKH81520"/>
        <property type="gene ID" value="AA958_04160"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_04160"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.873"/>
    <dbReference type="OrthoDB" id="1351747at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="16"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="334" mass="35457" checksum="13A199C9ED1F138B" modified="2015-07-22" version="1">MEHRQLGRTGLRVSRMGLGTLTWGRDTGEPEAAGLLKTFWEAGGTLVDTADVYADGGAEHLLGRLLRDLVPRRDIVVATKAGSVPDPERRFDTSRRHLLGALDASLERLGTDYVDLWQVHAFDPYTPMDETLQALDSAIASGRARYAGVSNFSGWQLAKAATWQLAGAGGGAGAAGGRTRLASTQMEYSLLQRGVEREVLPAALDLGVGLLPSSPLGRGVLTGKYRDATPAGSRLASEHLAPFVAPYLDEEASRVVDAVTTAADGLAVTPLEVSLAWVRDRPGVAAPLVGARNAEQLSAALSVEGLTLPDEICQALDDVSAPVHRYPDQDWSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MZB1</accession>
    <name>A0A0F7MZB1_9ACTN</name>
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        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_01465</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014416.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH81051">
        <property type="protein sequence ID" value="AKH81051"/>
        <property type="gene ID" value="AA958_01465"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_01465"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.322"/>
    <dbReference type="OrthoDB" id="1425840at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="290"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="32"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="171"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH81051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="315" mass="32669" checksum="6A869CB7EBB527E0" modified="2015-07-22" version="1">MTTAQAAATDTAAGTARAPRRAFLDWRVRFAALSVVWGFSFLLIKVGTDGFAPLQVTLGRMAFGSAVLVAALAIRREPLPRGARTWGHIAVAAFFINALPFSLFAYAELHISSSLAGICNATSPLWAMLLALLALREDRPTRRRVAGLALGFAGVLTVLGAWRGFTGQDPLGTVLALLAAACYAVGWIYVRRTLAGLGHSHLSVAGTQLLLGTAQLAVATVLFTSVPTALPAGPLLAVVTLGVLGTGLAVLVQHGLVADVGPTTAHTVTYVIPVIATAAGVALLGEELTWNTPVGAAVVLAGAALSRSRPREERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MZD1</accession>
    <name>A0A0F7MZD1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="14">CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">AA958_01580</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CNQ-509</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; phospholipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="11">Phospholipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014435.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_01580"/>
    <dbReference type="EnsemblBacteria" id="AKH81071">
        <property type="protein sequence ID" value="AKH81071"/>
        <property type="gene ID" value="AA958_01580"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_01580"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.347"/>
    <dbReference type="OrthoDB" id="1702107at2"/>
    <dbReference type="UniPathway" id="UPA00085"/>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008444">
        <property type="term" value="F:CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004570">
        <property type="entry name" value="Phosphatidylglycerol_P_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000847">
        <property type="entry name" value="Phos_ph_gly_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="10" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AKH81071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="206" mass="22908" checksum="278ADDA859C2620F" modified="2015-07-22" version="1">MEAQETAESKDRIFTVPNLLSMSRLVLVPVFLWLILWPEFGGPNADGWALAILAFSGVSDYLDGKLARRWNQVSNLGRILDPAADRLYILATLVGLTWRGILPLWLTILLLSRDAIVGVAVWLLGRHGYPPPQVNFLGKSATFCLMYAFPLLLLSDASGWVSSLSAIFGWAFAGWGTALYWWAGGLYLIQVRRLIREDARADTTPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MZT8</accession>
    <name>A0A0F7MZT8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Citrate synthase (unknown stereospecificity)</fullName>
            <ecNumber evidence="2">2.3.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_02415</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Carbohydrate metabolism; tricarboxylic acid cycle.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.16" evidence="2"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014579.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_02415"/>
    <dbReference type="EnsemblBacteria" id="AKH81216">
        <property type="protein sequence ID" value="AKH81216"/>
        <property type="gene ID" value="AA958_02415"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_02415"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.517"/>
    <dbReference type="OrthoDB" id="1412360at2"/>
    <dbReference type="UniPathway" id="UPA00223"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036440">
        <property type="term" value="F:citrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010093">
        <property type="entry name" value="SinI_DNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739">
        <property type="entry name" value="PTHR11739"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00143">
        <property type="entry name" value="CITRTSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="SSF48256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01764">
        <property type="entry name" value="excise"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="4">
        <location>
            <begin position="8"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="58"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH81216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="420" mass="43421" checksum="932B899AB178CD41" modified="2015-07-22" version="1">MAEETRDALTTREAAERLGVKPETVYAYVSRGLLSSSKAPGGRGSLFDAREVDALARRHRRPHAAVATAPATGEDGETPAGTPVRTGITLIERDRYFFRGVDATALAAAYGYEEVAGWLWTGRLTPGVRFTAPPGLLAAATAAVAALPAHAGPVDRLRAAVVAAAAADPLRFDLADDAVRATARGLVATMATALPLTGPAHAPDAPVARRLWARLTALPPDAGSVRCLDTALTLLIDHDLAASTLATRVAASARAHPYAVVTTGLGALDGPLHGAASGLAHRMLAEALARGSAAAVVSDHLRAGRRVPGLGHRLYAGEDPRAEVLFALLDGIPRAAAALAAAREVAEITARDVPVRPNVDLALAVLSVSAGMPAEAGETVFAVARTAGWVAHALEEYAERPLRMRPSGRYTGPPPAQPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N059</accession>
    <name>A0A0F7N059_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Orotidine 5'-phosphate decarboxylase</fullName>
            <ecNumber evidence="7">4.1.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">OMP decarboxylase</fullName>
            <shortName evidence="7">OMPDCase</shortName>
            <shortName evidence="7">OMPdecase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">pyrF</name>
        <name evidence="9" type="ORF">AA958_03100</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>H(+) + orotidine 5'-phosphate = CO2 + UMP</text>
            <dbReference type="Rhea" id="RHEA:11596"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57538"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="EC" id="4.1.1.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the OMP decarboxylase family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.23" evidence="7"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014691.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_03100"/>
    <dbReference type="EnsemblBacteria" id="AKH81331">
        <property type="protein sequence ID" value="AKH81331"/>
        <property type="gene ID" value="AA958_03100"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_03100"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.661"/>
    <dbReference type="OrthoDB" id="1181405at2"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004590">
        <property type="term" value="F:orotidine-5'-phosphate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01215">
        <property type="entry name" value="OMPdecase_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018089">
        <property type="entry name" value="OMPdecase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011995">
        <property type="entry name" value="OMPdecase_type-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001754">
        <property type="entry name" value="OMPdeCOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43375">
        <property type="entry name" value="PTHR43375"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00215">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00934">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02127">
        <property type="entry name" value="pyrF_sub2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00156">
        <property type="entry name" value="OMPDECASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="6 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 7" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OMPdecase" evidence="8">
        <location>
            <begin position="22"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH81331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="283" mass="28940" checksum="B36BE1E2A4008406" modified="2015-07-22" version="1">MSPEPAEPFGRRLHRATAARGPMCVGIDPHAALLARWELPDDPAGLERFAMTAVEALADRVAVLKPQSAFFERFGSRGVAVLEKAVAAARAAGALVLMDAKRGDIGSTMGGYAAAYLGEDAPLRSDALTVTPYLGYESLRPALDAAHAAGAGLFVVTLTSNPEGAEVQRAAVHGAHGARTVAQTMLDHIAAENRGAEPLGSVGAVVGATLAEAGADLAVNGPLLAPGIGAQGAAPADLPRVFGAALPQVLPSASRSVLAHGPDIRRLRTAAEQLADDVRNVYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N078</accession>
    <name>A0A0F7N078_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Glutamine synthetase</fullName>
            <ecNumber evidence="9">6.3.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AA958_07050</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + L-glutamate + NH4(+) = ADP + H(+) + L-glutamine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:16169"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.1.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 8">Oligomer of 12 subunits arranged in the form of two hexagons.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glutamine synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.2" evidence="9"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015365.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_07050"/>
    <dbReference type="EnsemblBacteria" id="AKH82015">
        <property type="protein sequence ID" value="AKH82015"/>
        <property type="gene ID" value="AA958_07050"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_07050"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1476"/>
    <dbReference type="OrthoDB" id="416474at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamate-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008147">
        <property type="entry name" value="Gln_synt_b-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027303">
        <property type="entry name" value="Gln_synth_gly_rich_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004809">
        <property type="entry name" value="Gln_synth_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001637">
        <property type="entry name" value="Gln_synth_I_adenylation_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027302">
        <property type="entry name" value="Gln_synth_N_conserv_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03951">
        <property type="entry name" value="Gln-synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="SSF54368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00653">
        <property type="entry name" value="GlnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00180">
        <property type="entry name" value="GLNA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00182">
        <property type="entry name" value="GLNA_ADENYLATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00181">
        <property type="entry name" value="GLNA_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gln-synt_C" evidence="10">
        <location>
            <begin position="101"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-AMP-tyrosine" evidence="6">
        <location>
            <position position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR604809-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AKH82015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="471" mass="52400" checksum="901281E795A61DF4" modified="2015-07-22" version="1">MFQNADEVQQYIADNDVKFVDVRFCDLPGIMQHFTVPVDVFEPDGQLMFDGSSIRGFQAIHESDMALVPDLSTSRLDPFRKDKTLNVNFFIHDPITGEQYSRDPRNVAKKAEAYLASSGIADTAYFGPEAEFYVFDDVRFETKANAGYYHIDSEAGAWNTGAIEDGGNRGYKVRYKGGYFPAPPVDHFADLRAEISLELAASGLQVERQHHEVGTAGQAEINYKFNTLLAAADDLMLFKYIVKNVAWRNGKTATFMPKPIFGDNGSGMHCHQSLWAGGEPLFYDEQGYAGLSDTARYYIGGILRHAPALLAFTNPTVNSYHRLVPGFEAPVNLVYSQRNRSAAIRIPITGASAKAKRIEFRAPDSSGNPYLAFSAMLLAGLDGIKNKIEPAEPVDKDLYELAPEEHAAVPQVPTNLPAVLESLEADHEFLLQGGVFTADLIETWIDFKRTQEIAPIQLRPHPHEFELYFDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0A3</accession>
    <name>A0A0F7N0A3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_03320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014730.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_03320"/>
    <dbReference type="EnsemblBacteria" id="AKH81371">
        <property type="protein sequence ID" value="AKH81371"/>
        <property type="gene ID" value="AA958_03320"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_03320"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.706"/>
    <dbReference type="OrthoDB" id="1975541at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023353">
        <property type="entry name" value="LemA-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140478">
        <property type="entry name" value="SSF140478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="71"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="184" mass="19935" checksum="2DF3DF32374B1126" modified="2015-07-22" version="1">MSTALTLLLVAVGLCLIGVYLSWTAGRLDRLHTRIDAAKAALDAQLLRRASVAQELATSGVLDPAASIVLYEAAHAARQAEEDQREVAESELSQALRAVFEAPEQVEAVRGAPGGEEAVHELAEAARRVPMARRFHNDAVRAARALRRHRKVRWFRLAGHAPFPLAVEMDDEPPPALTDRAPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0B0</accession>
    <name>A0A0F7N0B0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">zf-CGNR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_03400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014744.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_03400"/>
    <dbReference type="EnsemblBacteria" id="AKH81386">
        <property type="protein sequence ID" value="AKH81386"/>
        <property type="gene ID" value="AA958_03400"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_03400"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.721"/>
    <dbReference type="OrthoDB" id="1770002at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010852">
        <property type="entry name" value="ABATE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023286">
        <property type="entry name" value="ABATE_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021005">
        <property type="entry name" value="Znf_CGNR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35525">
        <property type="entry name" value="PTHR35525"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07336">
        <property type="entry name" value="ABATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11706">
        <property type="entry name" value="zf-CGNR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160904">
        <property type="entry name" value="SSF160904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-CGNR" evidence="2">
        <location>
            <begin position="139"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH81386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="211" mass="22422" checksum="C46E16D493B1092D" modified="2015-07-22" version="1">MLINHDTRCALDIVVALLNTDAGDGGEEADVLVDVRALQSFVDEHEISGLEALCRSDLDAVRAVRRDLSAVFAAPDDRTAAERLNAIVAAAGTTPQLTDHDGYEWHVHYFAPGASVAEHLAADGGMALAFLVVAGERERLRRCEAPDCGRAFVDYSRNRSRRYCSSRTCGNRLHVAAYRARQREAAAENGTGNGNGKAAAGAAGGAALTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0D4</accession>
    <name>A0A0F7N0D4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetyl-gamma-glutamyl-phosphate reductase</fullName>
            <shortName evidence="4">AGPR</shortName>
            <ecNumber evidence="4">1.2.1.38</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">N-acetyl-glutamate semialdehyde dehydrogenase</fullName>
            <shortName evidence="4">NAGSA dehydrogenase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">argC</name>
        <name evidence="7" type="ORF">AA958_03645</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>N-acetyl-L-glutamate 5-semialdehyde + NADP(+) + phosphate = H(+) + N-acetyl-L-glutamyl 5-phosphate + NADPH</text>
            <dbReference type="Rhea" id="RHEA:21588"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29123"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57936"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.38"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.38" evidence="4"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014789.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_03645"/>
    <dbReference type="EnsemblBacteria" id="AKH81431">
        <property type="protein sequence ID" value="AKH81431"/>
        <property type="gene ID" value="AA958_03645"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_03645"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.767"/>
    <dbReference type="OrthoDB" id="951261at2"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00108"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003942">
        <property type="term" value="F:N-acetyl-gamma-glutamyl-phosphate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00150">
        <property type="entry name" value="ArgC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023013">
        <property type="entry name" value="AGPR_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000706">
        <property type="entry name" value="AGPR_type-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012280">
        <property type="entry name" value="Semialdhyde_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02774">
        <property type="entry name" value="Semialdhyde_dhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01850">
        <property type="entry name" value="argC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01224">
        <property type="entry name" value="ARGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0521">NADP</keyword>
    <keyword evidence="3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Semialdhyde_dh" evidence="6">
        <location>
            <begin position="4"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="active site" evidence="4 5">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH81431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="342" mass="34567" checksum="300DCB5945EE5BC5" modified="2015-07-22" version="1">MTVRVAVAGASGYVGGELLRVLLGHPGVEIGALTAHANAGRPLGDIQPHLAPLAGRELAGTAPGVLAGHDVVFLALPHGQSAAVAAELGDDVLVVDCGADHRLADAADWERFYGTPHAGTWPYGLPELPGHRDALLGVRRIAVPGCYPTAVSLGLFPAYAAGLAEPEAVVVAASGTSGAGKALKPHLLASEVMGSMSPYGVGGGHRHTPEIGQNLSAVAGEPVTVSFTPTLAPMPRGILATSTARARPGTTAEAVRAAYEKAYQGEPFVRLLPPGQWPATGAVTGSNTVLLQVAYDESARRIIAVSAIDNLTKGTAGGAVQSMNIALGLPEELGLSTTGVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0I3</accession>
    <name>A0A0F7N0I3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_00635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH80918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014284.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH80918">
        <property type="protein sequence ID" value="AKH80918"/>
        <property type="gene ID" value="AA958_00635"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_00635"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.147"/>
    <dbReference type="OrthoDB" id="1928533at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="SNARE_assoc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="SNARE_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH80918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="223" mass="24111" checksum="9C2DCDAA3E354EFC" modified="2015-07-22" version="1">MILEPQVWAAAPADSSGNWATDLMESLGSPGVAIATGLESLFPTVPSELVLLLGGYTARLGDLNFFALVCWSTLGSVIGSVLHYYVGALLGRRRTRAIFIRFPLVQESDLDRAEGWFGRYGAKAVLVGRLIPIVRSYVSLPAGIERMAMPLFVAYTAIGSLVWNLVLLTVGYAVGSSHDTVEQYANGFTAVVGAVLLVLVARFVVVRLRARRRERREAPAESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0I6</accession>
    <name>A0A0F7N0I6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_07775</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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    <dbReference type="PATRIC" id="fig|444103.5.peg.1636"/>
    <dbReference type="OrthoDB" id="1143318at2"/>
    <dbReference type="Proteomes" id="UP000034283">
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="PFTB_repeat"/>
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        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
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            <end position="441"/>
        </location>
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        <location>
            <begin position="413"/>
            <end position="435"/>
        </location>
    </feature>
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        <location>
            <begin position="382"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH82150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="441" mass="43238" checksum="A7B82DD33C2D2D67" modified="2015-07-22" version="1">MAPIGRTAAARGTRAALAAAVLLPLTVAGPASAASAATAPQAAPRVAAQGAPAQAVPAQKKLPEGLYGTADPEFDGVWRQSLALLAQRSQQLRPAPAAVAFLTGQQCADGGFAAYRADVAKPCDEAAEDTNATAAAVQALSAVGGERKAVAEGVAWLKEIQNEDGGWGFNPGGPTDANSTAVVVGALAAVGEEPEKTTAGGGSPYDALATLQLGCDAKKAERGAYAYQPEDDGALFPNDYATAAAVLAGTGSGLGAGLAKGGGKDEPVEAGACTEDPSPAEAADAGAAYLAQKLAAGDGHLPMVTGEGPDHNATAVAVLALAAGGHGSAAREPYGWLERDKGTLSWSKENPAALATLILAADAVDADPSAFAGGTDLVASLNATGPQPTAEKPATDPAASEESSDDDGGGPGVAVWSLLAVGLAAGAGIGLLASARRKKRA</sequence>
</entry>
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            <authorList>
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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    </dbReference>
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            <begin position="224"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="287" mass="32800" checksum="F22BD1A7E7CC5684" modified="2015-07-22" version="1">MSNREGAHAPHSPAAPVMPTVVDRRSFQAELDRLRAREKAHTREADAIAAARRRLPMVEVDADLELLGPLGPVTLLDAFEGRQQLIAYYFMRDPRRPAAEQCVGCTFYTTQVAELSYLHSRDITYAVFCQGRNDAVEEVEPQASYDQSLRYREFMDWRMPWYSALPSLDPLLVGRKIGLFHLVCYLRDGNRIFETYWTTRRGVEAKDYSYALMDLTVYGRQEPWEDSPPNWPQQCSNTRTNSGSPEWPPVPTWPGGRPAAQWPRLQAGRSDDLGTPEPPPDPPHRCH</sequence>
</entry>
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    <accession>A0A0F7N124</accession>
    <name>A0A0F7N124_9ACTN</name>
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        <lineage>
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="20"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="304" mass="32757" checksum="EF5B108AE97CF8C9" modified="2015-07-22" version="1">MGEPDGKPDPGLFGPASVTWQVHSDPVMWIAGVRALYLQALHPRAVRGVMQNSDFRADAWGRLMRTAAFVGTVTYAAAPAAERAGARVRGIHRRLRAVDPATGESYRVDEPALLLWVHCAEVGSYLDVARRSGLTIPDAYADAYLREQRTAARLVGLDPVTVPGDTAALAAYFADAAPELAATPEAADVDDFLRRPPVNALLVPARRLLWRRVAGLAYATLPPIAHELYGRPAPPPAVVDRRLRATAALLRAVPAGLRWRLPPRNILKAMDRLGPASRPSPSTLVRTAAILDESGDMATGNSHE</sequence>
</entry>
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    <accession>A0A0F7N1G7</accession>
    <name>A0A0F7N1G7_9ACTN</name>
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            <fullName evidence="1">YceI domain-containing protein</fullName>
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    </gene>
    <organism evidence="2 3">
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        <lineage>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YceI" evidence="1">
        <location>
            <begin position="93"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="264" mass="28526" checksum="F62493E98A87BAE7" modified="2015-07-22" version="1">MLSCRVLDPVDQPLPQAEIVLADAAGRKVVSGESDPFGTFVVAVPAGSYRLSINAEGFTPYRGEIEVAEGAHNSLGDLALGPSPLPQLPPPGDWEIDPAHTTIAFVAQHIGMARVRGRFNAFNGALRIGRRMEDSAMRVAIEAASIDTNIKMRDDHLRSPDFLDVERYPAIEFAGDRFLHRGGARWAVTGALSIHGVSRTVTLDTRYLGTGYGMEGELRAACRATAELHREDFTLTWQHMLARGIAVVGSSIQIELDIQVVAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N256</accession>
    <name>A0A0F7N256_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alkaline phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_07420</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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    <dbReference type="STRING" id="444103.AA958_07420"/>
    <dbReference type="EnsemblBacteria" id="AKH82086">
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        <property type="gene ID" value="AA958_07420"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_07420"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1555"/>
    <dbReference type="OrthoDB" id="165142at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd07389">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018946">
        <property type="entry name" value="PhoD-like_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038607">
        <property type="entry name" value="PhoD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032093">
        <property type="entry name" value="PhoD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09423">
        <property type="entry name" value="PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16655">
        <property type="entry name" value="PhoD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519079" evidence="1">
        <location>
            <begin position="44"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="domain" description="PhoD_N" evidence="3">
        <location>
            <begin position="59"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="PhoD" evidence="2">
        <location>
            <begin position="168"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH82086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="540" mass="59680" checksum="719AD5889177470D" modified="2015-07-22" version="1">MTPPHPQDALRAAAAHVSRRRFLTVTGAAAALAFSVGLPQAHADEPADPGTIRQEPFTLGVASGDPAPDGVVLWTRLAPAAFEPDGGMPPAPFPVDWEIAHDEGFRRVVRRGRELAHPEFHHTVHAEVDGLAPGRPYYYRFRLGPWISPVGRTSTAPPQHARNSAMRFGVVACQNYPGGYYTAFKHLANEDLDAVFHLGDWIYEGAVASTGGSRAYPAGTLPAVFNHETVTLEDYRLRYALYRSDADLRAAQAAHPWILTWDDHEVENNYAGAISQDNLPPDEFLVRRAAAYRAYWENQPLRRPQRPRGADLRLYRRLHYGTLAQFDVLDGRQYRSDQAYGGAWARPGGDADDPARTMLGERQEHWLADGWRDSRARWNVVPQQVVLAERRSEPIGEYTVSMDAWDGYTAARTRFLDAAEAAGVENLVVLTGDVHVHYAMDVKRDYADPAAPAVASEIVATSISSGGNGAERPASYDRLTQANPHLRFYDGRRGYVTVALDREQCRADFRVVPYITTEGAPVATAASYAIEAGRPGLHRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N284</accession>
    <name>A0A0F7N284_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_07580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015466.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH82116">
        <property type="protein sequence ID" value="AKH82116"/>
        <property type="gene ID" value="AA958_07580"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_07580"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1589"/>
    <dbReference type="OrthoDB" id="801313at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH82116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="489" mass="53640" checksum="23B4293A2728103C" modified="2015-07-22" version="1">MDRPAEMFDRDFEWSELARFAALPGSRATLGVVSGRRRQGKTFLLDALIRASGGFMFTATETTEADALRQFGAALAHYRDQPTPFRFADWGEAVTELMRIADGGSPVTAVIDEFPFVAKASPALPSIIQRALDPTAQRINTPVRLLLCGSALSFMGGLLAGNAPLRGRAGLELVVPTLDFRLAAEFWEIADPRTALLTHAIVGGTPAYRREFTQGDAPVDPDDFDAWVVRAVLNPARPLFREARYLLAEEPELHDTALYHSVLAAIAAGNAARGGIADYLGRKSTDLAHPLSVLQDVGMITHEADAFRRNRSAYRIAEPLIAFYHAVMRPAWGDLERPGRAGAVWRRAQSTFRSKVVGPHFEQVCREWARWHASAETHGGVATRVASGTVNDPAAKTSHEVDVAVHGETENGVEGLLAIGEVKWNDVMGQRHLDRLQRIRSLLMARGTATDATRLHCYSAAGFTDDLRLRAESDPTIQLIEPHRLYHGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2B4</accession>
    <name>A0A0F7N2B4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycosyl transferase family 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_11425</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016076.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_11425"/>
    <dbReference type="EnsemblBacteria" id="AKH82740">
        <property type="protein sequence ID" value="AKH82740"/>
        <property type="gene ID" value="AA958_11425"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_11425"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2404"/>
    <dbReference type="OrthoDB" id="1445278at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH82740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="343" mass="36501" checksum="821B356DF2E6171D" modified="2015-07-22" version="1">MNDFATPPAVSVIMPVLNEERHLREAVRHILEQDYEGELEVVIALGPSTDGTDAIAAELVRETADGARCRVQTVPNPTGRTPAGLNAAIAASSHPVVVRVDGHGMLSPGYISTAVRLLAETGAQNVGGIMHAEGETSWEQAVAAAMTARIGVGNAAFHTGGEAGPADTVYLGVFRREALEQQGGYNEEFIRAQDWELNFRIRSAGGAVWFSPELRVSYRPRPNLRALAKQYKDYGRWRRVVARYHKGSINPRYLAPPAALAGIVAGVLVTPLTPLGLAIPLAYAVGIAAGSVPAGRGLPARARVQIPVALATMHMSWGWGFLTSPRSLAQKVIASRRPAVTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2B5</accession>
    <name>A0A0F7N2B5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_07780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_07780"/>
    <dbReference type="EnsemblBacteria" id="AKH82151">
        <property type="protein sequence ID" value="AKH82151"/>
        <property type="gene ID" value="AA958_07780"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_07780"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1637"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519702" evidence="2">
        <location>
            <begin position="43"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH82151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="242" mass="24513" checksum="841DBAE57BC49210" modified="2015-07-22" version="1">MTSGGQPRRGRRTIRQAIPRVLVAVVGGALLVLGAGAPGAQAAEGYRYWSFWDRDGDSWVYATKGPGLERPADGDVHGVRFAVSEESGGGPRPRGAAGFDAICGGTPPGDGGKRVALVLDFGTAADAPGGRTPPPARTECASVAEDATLGDALAAVAEPLRYDSNGLLCAIDGYPRSGCAEPAASDDGAGAGEARDKVDISTVPADEADDGDSGPSTGTVGGLVMVAVLAGLTVWQLRRRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2R8</accession>
    <name>A0A0F7N2R8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_12425</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016240.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH82905">
        <property type="protein sequence ID" value="AKH82905"/>
        <property type="gene ID" value="AA958_12425"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_12425"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2611"/>
    <dbReference type="OrthoDB" id="2047542at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="22"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH82905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="220" mass="24164" checksum="394A7377C018B934" modified="2015-07-22" version="1">MGRGKGATLTGQRQPRMRADASRNRERIIDAAREAFVEWGPDVPLDEIARRAGVGNATVYRNFADRRELILQVTLESMRRIADLAEAALAEDTEAFEALRGFVHRGADERIGSLCPLLVDGFDHAAPEVMGMRERLDTALEDLMARARAEGTLRSDVGVGDLMVALAQLTRPLPGLECTVGFDTYMHRHLELFLDGLMNPARSTLSGSAATFEALRQKGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N356</accession>
    <name>A0A0F7N356_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Metal-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_09580</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015780.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_09580"/>
    <dbReference type="EnsemblBacteria" id="AKH82436">
        <property type="protein sequence ID" value="AKH82436"/>
        <property type="gene ID" value="AA958_09580"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_09580"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2019"/>
    <dbReference type="OrthoDB" id="1878295at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.40.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007899">
        <property type="entry name" value="CHAD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038186">
        <property type="entry name" value="CHAD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033469">
        <property type="entry name" value="CYTH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023577">
        <property type="entry name" value="CYTH_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05235">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF55154"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51707">
        <property type="entry name" value="CYTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="5"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="CHAD" evidence="3">
        <location>
            <begin position="256"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH82436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="540" mass="59248" checksum="85FF4D23B0E6E428" modified="2015-07-22" version="1">MVDTVREIERKYEATAGTRELPPLPDLTGVHGVASVIDQGTALLDAVYYDTAARRLAADGITLRRRTGGDDAGWHLKLPVAAGVRDEIRAPLGEGIPRRLAALVRSRTRDAELAPVVRIRTERDVHQLLDADGEPVAEVSVDRVTAERPETGATARWAEVEAELSAGGDPEVLDAVDAALTGAGLRRSTAPSKLARALAETDERKQKGDKKNDKKPNTGKDGKKKSADKKKPDKKKPGKKGEKKKAAGKKHPEPAARPAGDLVLDYVRAQITAVVELDPAVRRDQPDAVHQMRVASRRLRSTFRSYRAVLDRTVTDPVSAELRWLAGELGVDRDREVLTERIHAALAELDRPLVLGPVRGRLRTWSAARRTGSRRRIVAVLDGGRYLALLDALDAILTDPPLRTAAERPAEPVLRKAVDRQYRRFAGSLQETFDLAPGPDRDTAIHETRKAAKRTRYAAEVARPALGREAKTVTSLMREVQELLGDYQDGVLARSALREIAVQAQAAGEPSFTYGVLYAREEARAAELRDLLPRLSRKHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3B3</accession>
    <name>A0A0F7N3B3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_06130</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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    </dbReference>
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AKH81854">
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        <property type="gene ID" value="AA958_06130"/>
    </dbReference>
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    <dbReference type="PATRIC" id="fig|444103.5.peg.1280"/>
    <dbReference type="OrthoDB" id="1717935at2"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:cellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008217">
        <property type="entry name" value="Ccc1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31851">
        <property type="entry name" value="PTHR31851"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="VIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
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    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH81854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="242" mass="24843" checksum="3C3F9AF9A423BC50" modified="2015-07-22" version="1">MSAGLQAGGPAERHGPTHRDVTGGWLRPAVFGAMDGLVSNLALITGVAGGSVSSTTIVLTGLAGLAAGAFSMAAGEYTSVASQRELVLAELDVERRELSRHPEDELQELSDLYESRGVDPELAAEVSRQLMRDPEQALEIHAREELGIDPGDLPSPPVAALSSFGSFAVGALLPVLPYLLGATALWPAVLLALAGLFACGAAVARITARTWWYSGLRQLLLGGAAAAVTYGLGALFGATVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3M1</accession>
    <name>A0A0F7N3M1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_06880</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015336.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_06880"/>
    <dbReference type="EnsemblBacteria" id="AKH81984">
        <property type="protein sequence ID" value="AKH81984"/>
        <property type="gene ID" value="AA958_06880"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_06880"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1438"/>
    <dbReference type="OrthoDB" id="983275at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="415"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="450"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH81984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="578" mass="57313" checksum="066BC7112E91F777" modified="2015-07-22" version="1">MSTEHTPGPVPEPEPAHARAAGPDGRDADDAGGAGEPGRPDGGRRRPGVLVAAAVAAAVMLTGGGVAYLVDRTDDGGGAGSDGGEPPPLRLDGLSMEAAARGGSAPLRLVGELPEGPEEAPVFEPAGRVGAADVARLAAALGMDGKPREEGGGWRVGVSRDGQGPLLQVQAEAPGAWTYQQYGGTACDLPLPAEPDGAGPDAAVTSACEVPVPRPRTKADAPVPADAAEKAAEPVLAAVGQEDAEVAAAEPFGAVRTVTAEPVVGGLPTTGWQTSLQIAGDGQVTGGNGYLVDPAEADTYPVITADAAFEELARPSGGGGEPAVAPACASAVPYEEGTGPGKPPAGKVDPCLGKMAPTKVRGAEFGLSAQSVEGRPVLVPSWLFQVTSDAPAPFHGGKPGTVVWPQLAVAPEYVTEAEPSAPAVPEPAPPTSAPGAEPTAGGGSAGRPGSPAPSESSDSGQGSPGQVGPAEPAQPPSSAPAEEPESRGGAVGSPVGIESYSVDGRTLKLHFWGGVCTEYAATADEAGGAVTVRLTGEDEPGEVCIKIAKRFTETVELSAPLDGRKVVDARTGERVAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3N0</accession>
    <name>A0A0F7N3N0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Arginine repressor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">argR</name>
        <name evidence="12" type="ORF">AA958_03625</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Regulates arginine biosynthesis genes.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Amino-acid biosynthesis; L-arginine biosynthesis [regulation].</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the ArgR family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014785.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_03625"/>
    <dbReference type="EnsemblBacteria" id="AKH81427">
        <property type="protein sequence ID" value="AKH81427"/>
        <property type="gene ID" value="AA958_03625"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_03625"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.763"/>
    <dbReference type="OrthoDB" id="1640037at2"/>
    <dbReference type="UniPathway" id="UPA00068"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034618">
        <property type="term" value="F:arginine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051259">
        <property type="term" value="P:protein complex oligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00173">
        <property type="entry name" value="Arg_repressor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001669">
        <property type="entry name" value="Arg_repress"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020899">
        <property type="entry name" value="Arg_repress_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036251">
        <property type="entry name" value="Arg_repress_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020900">
        <property type="entry name" value="Arg_repress_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34471">
        <property type="entry name" value="PTHR34471"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01316">
        <property type="entry name" value="Arg_repressor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02863">
        <property type="entry name" value="Arg_repressor_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01467">
        <property type="entry name" value="ARGREPRESSOR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55252">
        <property type="entry name" value="SSF55252"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01529">
        <property type="entry name" value="argR_whole"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="5 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0678">Repressor</keyword>
    <keyword evidence="8 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Arg_repressor" evidence="10">
        <location>
            <begin position="13"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Arg_repressor_C" evidence="11">
        <location>
            <begin position="103"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AKH81427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="174" mass="18558" checksum="0E28C23CEBB86F78" modified="2015-07-22" version="1">MSEEHNGPAVPHTRTARHRRIVDILNRQPVRSQSQLAKLLADDGLTVTQATLSRDLDELGAVKIRNTGGELIYAVPSEGGFRTPQVPLGESAKEERMARLAGELLISAEASANIVVLRTPPGAAQFLASAIDAAELTPILGTIAGDDTLMVISRNPSGGQSLADHLLKLAERER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3N6</accession>
    <name>A0A0F7N3N6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6 7">50S ribosomal protein L20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rplT</name>
        <name evidence="8" type="ORF">AA958_03795</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6 7">Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the bacterial ribosomal protein bL20 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014815.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_03795"/>
    <dbReference type="EnsemblBacteria" id="AKH81457">
        <property type="protein sequence ID" value="AKH81457"/>
        <property type="gene ID" value="AA958_03795"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_03795"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.798"/>
    <dbReference type="OrthoDB" id="1932144at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07026">
        <property type="entry name" value="Ribosomal_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1900.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00382">
        <property type="entry name" value="Ribosomal_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005813">
        <property type="entry name" value="Ribosomal_L20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035566">
        <property type="entry name" value="Ribosomal_protein_L20_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10986">
        <property type="entry name" value="PTHR10986"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00453">
        <property type="entry name" value="Ribosomal_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00062">
        <property type="entry name" value="RIBOSOMALL20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74731">
        <property type="entry name" value="SSF74731"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01032">
        <property type="entry name" value="rplT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00937">
        <property type="entry name" value="RIBOSOMAL_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 6 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH81457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="128" mass="14385" checksum="F8FB8389456FA7DE" modified="2015-07-22" version="1">MARVKRAINAQKKRRAILEQASGYRGQRSRLYRKAKEQVTHSLVYNYNDRKKRKGDFRQLWIQRINAAARANGITYNRFIQGLKAAGVEVDRKMLAELAVNDAGAFAVLVEVAQKALPSDVNAPKSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3P6</accession>
    <name>A0A0F7N3P6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">XRE family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_06770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_06770"/>
    <dbReference type="EnsemblBacteria" id="AKH81963">
        <property type="protein sequence ID" value="AKH81963"/>
        <property type="gene ID" value="AA958_06770"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_06770"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1415"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="11"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="194" mass="21105" checksum="40C4A70B3C643A80" modified="2015-07-22" version="1">MSTEHPQAPHLRELRRRAGLTLEAAAARAELSPAHLSRLETGQRQPSLPVLLKLARVYGTTVSELLGEVSSAQTSVVRGAEVPVREAGGWSYRQAGGTDRGMQALRVFVPYDAEHRDLVRVHPGEEWLYVLDGRMRLVLGDREHLLDPGDSAQFDSLTPHRIAAAEPGGLGLLFVHTLLQSAVTGLCLGDGTRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3T7</accession>
    <name>A0A0F7N3T7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_07175</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015389.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH82039">
        <property type="protein sequence ID" value="AKH82039"/>
        <property type="gene ID" value="AA958_07175"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_07175"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1503"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001434">
        <property type="entry name" value="DUF11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01345">
        <property type="entry name" value="DUF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01451">
        <property type="entry name" value="B_ant_repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519016" description="DUF11 domain-containing protein" evidence="3">
        <location>
            <begin position="29"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="DUF11" evidence="4">
        <location>
            <begin position="49"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH82039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="218" mass="22631" checksum="F2BDD7F3C07F315F" modified="2015-07-22" version="1">MRTAIASAAMVAGLLASLAPSPPLSPDAPPAELPSSPIRLALERRAAPDGGTTYAITVHNTSGADAPNGRVTQLLPESLDYVSASPRAETTGQQVTWEITLPAGTTRVLKVTAAPDRTERDGRDLRAAHAAGDVRAPRDAGAGDRAPAAATTVCFQGGTRGEWLTCTSADDEWSPEPWVSSNKVYAIGSAAAALLVGTAGIIILRRRRSRDTEDDGPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3X5</accession>
    <name>A0A0F7N3X5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_07270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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        <location>
            <begin position="49"/>
            <end position="77"/>
        </location>
    </feature>
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        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="77" mass="8725" checksum="01BA629C5B8697EE" modified="2015-07-22" version="1">MALFKKKTAGKPGEWYYCLEHKKVEEGPQCRALNRLGPYATPEEAARAIETAEARNEEWDEDSRWNDEGDRGGGPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
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            <authorList>
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
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            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="276" mass="30040" checksum="3848928E04F45701" modified="2015-07-22" version="1">MTNNDQNIHLIIGGTGKTGRHVARTLAARGHAVRAVSRRSDTPFDWHAPGTWPPALRGVRTAYLTYAPDLADPAAAPAIRAFTETAVRAGVQRLVLLSGRGEPECHPSEDAVKESGAQWTIVRCAWFMQNFDEDFLLEPVLSGELVLPAADIPEPFLDTRDIADVVVAALTEDGHSGTTYELSGPRLLTFGEAAAEIGKATGRDVRYVPVTPEQFREAVTGHLPQELVEIFAELFTRILDGRNAHLTDGVRKALGRAPRDFTDFVREAAARGAWNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
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    <organism evidence="2 3">
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    <reference evidence="2 3" key="1">
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="264" mass="27483" checksum="444BA1EEE1E93BA3" modified="2015-07-22" version="1">MTDAPAEPAADDAPLVRTARDDRGVTTLTLDSPHNRNALSTRLMAELDLGLAAAAEDDDVRAVLLTHTGNTFCAGADLGEATAAAAATDGPLALSRLLRAVVECPKPVVARVTGHVRAGGLGLLGACDIAAAGTGATFAFTEARLGLAPAVISMPLLPRLDARAAARYYLTGERFGPEEAARIGLVTLAGDDVDALLTPVLDGLRAASPQGLAASKRLVTGEVLRAFDRDTEPFAELSASLFASPEAREGMTAFLERREPKWFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5K1</accession>
    <name>A0A0F7N5K1_9ACTN</name>
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        <submittedName>
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    </gene>
    <organism evidence="2 3">
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        <lineage>
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    <reference evidence="2 3" key="1">
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
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        <property type="gene ID" value="AA958_07475"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_07475"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1567"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF06283">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ThuA" evidence="1">
        <location>
            <begin position="8"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="253" mass="28298" checksum="CBD3857921F19CD5" modified="2015-07-22" version="1">MPPRGPLRVTVWGEGLHEQRDAEVAKRYPQGMHGAVADGVSDHLGQEARVRTATLGEPEHGLTEEVLAATDVLTWWGQLAHREVSDEVVKRVHRRVLAGMGLIVLHSGHLSKIFTRLMGTTCTLRWRSAGDRELIWTTAPSHPIAAGVPHPIVIEQQEMYGEFFDIPTPDELIFISSFSGGEVFRSGCTFRRGHGKIFYFSPGDQDYPVYHHPHVRRVIANAVRWAAPDADHARPRLIHSGTDWFLNGDGVRE</sequence>
</entry>
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    <accession>A0A0F7N686</accession>
    <name>A0A0F7N686_9ACTN</name>
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        </submittedName>
    </protein>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
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        <lineage>
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    <reference evidence="2 3" key="1">
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    <dbReference type="OrthoDB" id="1914729at2"/>
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        <location>
            <begin position="149"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="312" mass="32265" checksum="C2F887B2054195D3" modified="2015-07-22" version="1">MDEHDWLAERFETGRPGLRPLAYRLLGPAEEAGREEWTRLGRRAPGAAGVAGAAGMPGVAADGLDGCMRTTVAQVTLHVLRSGPVVEMPEVSGPPADLPRSVRVTLLVVCETLLPPERLAYVLQDMFAAPFEEIAAVAALANRELAGSARRPGAAAGYGGTGYDRGPTGSGTDAGATTGADIAGAFLAASRGGDFRAMLTALDPNHPDRRPAADTPPASPGPAGEAAPHPAPAEHRGGDAVIGTTEVRGTESVTRVCTVRTWTPVPALIDGAAGLVWVQNGHPRVAFRFTVEDGEVTATELETDLSALSIVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6I0</accession>
    <name>A0A0F7N6I0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_12750</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP011492">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH82949">
        <property type="protein sequence ID" value="AKH82949"/>
        <property type="gene ID" value="AA958_12750"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_12750"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2679"/>
    <dbReference type="OrthoDB" id="1384345at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="294"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="326"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="365"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="391"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="29"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH82949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="428" mass="41824" checksum="08E2976FA08C077A" modified="2015-07-22" version="1">MSNIQEKHTAAGAPAEPPAPARSAVRGRLAVAAVTLGIFTVMTAELLPVGLLTPVGRDLGVSAGTAGLMVTVPGLVAAVSAPLLAVAAGRADRRLVLAGLMALVVAAHAASALAGHFAVVLGARVLLGVSIGGFWAFAGGLALRLVPEREVPRATAVIFGGVSAASVLGVPAGTLTGELGGWRVAFAVLGALALAVLAALVLLLPRLPAERGLRPADLARLPRESPAVRAGLVLTVLLVTGHFLAYTFIRPVLQERYGVGDGLVGVLLLGYGAAGLAGNFLAGAAAARNPRRTVLTVATGLAAALVATALLPALPGPAGAAAGGGAVPAVLLLAGWGLAYGGVSVGLQSWFLAAAPRAAEAATSLYVAAFCLSIAAGAALGGVLVDAVALGAAPAAGAILTLAAVVLCTRTTRIPPAAARTAAPAETP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6M4</accession>
    <name>A0A0F7N6M4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_17640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017030.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_17640"/>
    <dbReference type="EnsemblBacteria" id="AKH83726">
        <property type="protein sequence ID" value="AKH83726"/>
        <property type="gene ID" value="AA958_17640"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_17640"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3715"/>
    <dbReference type="OrthoDB" id="2015021at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019660">
        <property type="entry name" value="Put_sensory_transdc_reg_YbjN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10722">
        <property type="entry name" value="YbjN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="188" mass="21028" checksum="D28BF8FABC74A95D" modified="2015-07-22" version="1">MSIDPSSIPNFGGQQPESRGSGGPQGPIVPDQDLVKQLLDQMELKYVVDEEGDLAAPWEQFRTYFMFRGEDEQQLYSVRTFYDRQHSLDDKPELLEAIDDWNRRTLWPKVYTHTHDDGSVRLIGEAQMLIGTGVALEHFVSSTVSWVRASIEFDKWLVETLGLQQELDEGGDGEDGPGDAGGEGPKEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6M6</accession>
    <name>A0A0F7N6M6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">30S ribosomal protein S19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpsS</name>
        <name evidence="7" type="ORF">AA958_21195</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uS19 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_027772222.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_21195"/>
    <dbReference type="EnsemblBacteria" id="AKH84290">
        <property type="protein sequence ID" value="AKH84290"/>
        <property type="gene ID" value="AA958_21195"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_21195"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4464"/>
    <dbReference type="OrthoDB" id="1893906at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00531">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020934">
        <property type="entry name" value="Ribosomal_S15/S19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002222">
        <property type="entry name" value="Ribosomal_S19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005732">
        <property type="entry name" value="Ribosomal_S19_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023575">
        <property type="entry name" value="Ribosomal_S19_S15_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880">
        <property type="entry name" value="PTHR11880"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00203">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002144">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00975">
        <property type="entry name" value="RIBOSOMALS19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54570">
        <property type="entry name" value="SSF54570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01050">
        <property type="entry name" value="rpsS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00323">
        <property type="entry name" value="RIBOSOMAL_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH84290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="93" mass="10571" checksum="93080266A59157B0" modified="2015-07-22" version="1">MPRSLKKGPFVDDHLIKKVDTQNEAGTKNVIKTWSRRSMIVPAMLGHTIAVHDGKKHVPVFVTESMVGHKLGEFAPTRTFKGHVKDDRKSRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N765</accession>
    <name>A0A0F7N765_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Terpene synthase</fullName>
            <ecNumber evidence="2">4.2.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_14455</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the terpene synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.-" evidence="2"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016550.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_14455"/>
    <dbReference type="EnsemblBacteria" id="AKH83234">
        <property type="protein sequence ID" value="AKH83234"/>
        <property type="gene ID" value="AA958_14455"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_14455"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3042"/>
    <dbReference type="OrthoDB" id="1869158at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034686">
        <property type="entry name" value="Terpene_cyclase-like_2"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01020">
        <property type="entry name" value="Terpene_Cyclase_Like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="31"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU366034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH83234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="402" mass="43519" checksum="3CC0DD589D787167" modified="2015-07-22" version="1">MTGAPAEALRALLPLGPTGLGTAAAHPLAGYVPEAVPKPEAEPPARTKTGPEPASGAGPGTDSDSGSTAGPEAGTAPPPDGGGERGGLRIPPLHCPDALRNDPALGDEVNERLVAWAEEIGIFTGRIERLRSHQFGRLFMLAHPDCDDPDRLLAAAKCGLSEWSVDDHWVDEGEDPDPALLGERMALAHAVIDPVRLPARYMPQFEETVQREPVLRAFRSALAHLSRYASPTQVARLRHELAVMFVGYGQEAEWRSSARTPAVWEYLLHRYENAFFPCMVLVDPVSGYELPPDEFADARVRRTYLYAGTASVLLNDLYSMGKEDPTDTNLPNLIAAEEGCTLQEAVDRTALIHDELMHTYEMEAAALTAAGSPQLGRFLAGVWAWMGGCKEWHATSARYQTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-10-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N773</accession>
    <name>A0A0F7N773_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_18825</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH83911">
        <property type="protein sequence ID" value="AKH83911"/>
        <property type="gene ID" value="AA958_18825"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_18825"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3953"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH83911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="204" mass="20653" checksum="C73643B0F34EBB68" modified="2015-07-22" version="1">MVEGAGDASAEVEASVRAHVELEGTVGKVAGDCRHRIGVPGFAVAVVVLAGAGEGGAVEGVGGHRVSEVATGQGRLQDKGPEGAQSLKAADRFGVRAAFEGGQAQEGLADQLLAREKQGCELLECVAARDDGEAEDRVVEGFEIGREAAQVVDLFGEVDGGGQRALRGVVPWEGSRDRGQRVGACAAVVAGRPAGRAVVGFGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7M7</accession>
    <name>A0A0F7N7M7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Integrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_15680</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016720.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_15680"/>
    <dbReference type="EnsemblBacteria" id="AKH83408">
        <property type="protein sequence ID" value="AKH83408"/>
        <property type="gene ID" value="AA958_15680"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_15680"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3305"/>
    <dbReference type="OrthoDB" id="785253at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14659">
        <property type="entry name" value="Phage_int_SAM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="6">
        <location>
            <begin position="84"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="5">
        <location>
            <begin position="188"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH83408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="433" mass="48136" checksum="C0F31E560D13401A" modified="2015-07-22" version="1">MADVYDRWHKTYPKKDDKECPEHKGKVATSAHGKGKRWQVRYRDSSGEQRAVNFDRKVDAEAAADSIGNDLRQGTYIDPGAGKITLQRYAQQWLAAATAGMGTVDAYEGVIRNHIDPHLGRYELRSLSQPSLIQGWVKKLQQAGLEASTIAWAASILTAILDAAVDDGLIVKNPCKANSVKLPRKPKKKIVPWSVERVHAVIDHLPERFQTGGKLTFGCGLRQGEVFGIGIDDIDFHKQLVRVNRQIKLVRSTMVFALPKGDRVREIPLPEEVAEVLKQHIKAFPPKRVDLPWRTPDGEKRTYRLLFTTDEGKGYHRSVFNQYEWKAALAGAGVIPPREKGSPRYAAAPEDGMHALRHAYASVLLDAGESIKALSEYLGHSDPGFTLRTYTHLMPQSETRTRQAINGAFTRPRTACSAKDGRPCVCTECALAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N814</accession>
    <name>A0A0F7N814_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_20435</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017450.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_20435"/>
    <dbReference type="EnsemblBacteria" id="AKH84161">
        <property type="protein sequence ID" value="AKH84161"/>
        <property type="gene ID" value="AA958_20435"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_20435"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4306"/>
    <dbReference type="OrthoDB" id="1695614at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046037">
        <property type="entry name" value="DUF5995"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19458">
        <property type="entry name" value="DUF5995"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH84161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="262" mass="28895" checksum="D0985D1497716D6E" modified="2015-07-22" version="1">MAENIDEVVDGLAGIVRAAGRDGDRAGYFAALYRQVTVEVRRAIHEGRFDDGARMDRFDTLFGNRYFEAYDAWRRDRGGPRCWRETFGLLDDDRTVVVQHLILGVNAHINLDLAVAAARTSPGEDIRSLRRDFLLINDILARVVLAVEDSVGALSPLLSLLDTIGARTDEQILDFSVRQSREEAWHNAVLLAAQNEEQRAATIDRLDIRAAVLARLIAHPGGLAEPALQLIRSTESADIPANIAHLDRAMDQPATAPAPTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N877</accession>
    <name>A0A0F7N877_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Toxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_12915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016311.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH82977">
        <property type="protein sequence ID" value="AKH82977"/>
        <property type="gene ID" value="AA958_12915"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_12915"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2718"/>
    <dbReference type="OrthoDB" id="1996962at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="5"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="25"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="83" mass="8677" checksum="2BE31F4C1B963E98" modified="2015-07-22" version="1">MSTLAWFKSSYSGSEGGNCVEVALDWRKSSYSGSEGGQCVEVAATPAAVHVRDSKDPDGPALTFSADAWQAFTDFARGLGAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8F1</accession>
    <name>A0A0F7N8F1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphoribosylaminoimidazole-succinocarboxamide synthase</fullName>
            <ecNumber evidence="8">6.3.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">SAICAR synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">purC</name>
        <name evidence="10" type="ORF">AA958_17830</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + ATP + L-aspartate = (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate + ADP + 2 H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:22628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58443"/>
            <dbReference type="ChEBI" id="CHEBI:77657"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the SAICAR synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.6" evidence="8"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017060.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_17830"/>
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    </dbReference>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
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            <end position="272"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="HAMAP-Rule" id="MF_00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AKH83758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="305" mass="33757" checksum="AD02F6B4EB046400" modified="2015-07-22" version="1">MTGFVEKPQPVEVPGLVHLHTGKVRDLYEDAEGRLVMVASDRISAYDWVLPTEIPDKGRILTRLSLWWFERIAGIVPHHVLSTELPEGAPAAWAGRALVCRRLRMVPVECVARGYLTGSGLAEYAESGAVCGVDLPPGLTDASALPAPVFTPATKAEVGEHDENVTYDEVVRRVGPLVAAELRRVTLEVYGRGRDLARGRGLILADTKFEFGYTGDAIGEGELVLGDEVLTPDSSRYWAIDGWRPGRPQPSFDKQYVRDWLTSDVSGWDRHGEAPPPELPAEVVERTREKYVEAYERLTGERWDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8L2</accession>
    <name>A0A0F7N8L2_9ACTN</name>
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            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">AA958_21650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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    </dbReference>
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AKH84371">
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        <property type="gene ID" value="AA958_21650"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="1889547at2"/>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="117" mass="12583" checksum="74AC1CE5C783A1F4" modified="2015-07-22" version="1">MDVLINLFVASHIIGVAALLGGWLTQLKSLSTGDVRIAPSMVHGALVMLVTGFILVGLNEADDVELNQTKISVKSLILIAILVAVFIKRKEERIPKPYFAAIGLLTMANVVIATTWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N954</accession>
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    </gene>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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        <property type="gene ID" value="AA958_19785"/>
    </dbReference>
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    <dbReference type="PATRIC" id="fig|444103.5.peg.4169"/>
    <dbReference type="OrthoDB" id="1995573at2"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003749">
        <property type="entry name" value="ThiS/MoaD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02597">
        <property type="entry name" value="ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="SSF54285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH84048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="92" mass="9853" checksum="E5C21C847496FAA8" modified="2015-07-22" version="1">MSVNVRIPTILRTYTDGRAEVSAEGATLAEVIEDLEKNHRGIAGRVLDDQGKLRRFVNVYVNDDDVRFADGLQTPTPEGAGISIIPAVAGGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N970</accession>
    <name>A0A0F7N970_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH marR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_14860</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH83287">
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        <property type="gene ID" value="AA958_14860"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_14860"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3132"/>
    <dbReference type="OrthoDB" id="1681849at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
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    </dbReference>
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        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH83287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="167" mass="18876" checksum="42E13A413A272FA0" modified="2015-07-22" version="1">MMANTTQIALAAWESLLRAQATIAREFEYTGDWGDVLPREYAVLHALSDADDGRRITELMEDALLTQAGVSRLVARLETRGYVERRDDPDDARACRVALTARGRETYRSLGRAHARQVREVMTRALDPQAMETLRELTEALIAASPRPDPRPDPRPSHARSQRRRPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N994</accession>
    <name>A0A0F7N994_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphatidate cytidylyltransferase</fullName>
            <ecNumber evidence="7">2.7.7.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AA958_26020</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 1,2-diacyl-sn-glycero-3-phosphate + CTP + H(+) = a CDP-1,2-diacyl-sn-glycerol + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:16229"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="2.7.7.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the CDS family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.41" evidence="7"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018346.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_26020"/>
    <dbReference type="EnsemblBacteria" id="AKH85105">
        <property type="protein sequence ID" value="AKH85105"/>
        <property type="gene ID" value="AA958_26020"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_26020"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5479"/>
    <dbReference type="OrthoDB" id="1533756at2"/>
    <dbReference type="UniPathway" id="UPA00557">
        <property type="reaction ID" value="UER00614"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004605">
        <property type="term" value="F:phosphatidate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016024">
        <property type="term" value="P:CDP-diacylglycerol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000374">
        <property type="entry name" value="PC_trans"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01315">
        <property type="entry name" value="CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="68"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="97"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="120"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="291"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AKH85105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="309" mass="31462" checksum="6D365C15587EB2D1" modified="2015-07-22" version="1">MPIVSGDAPADEPSPGPSGGSGAPGDPSTPPPPAPKRRRGGRDLGAAIGVGLGLGAIVLATLFVVKVLFLGVIVVAVAVGLWELTSRLAEVRGIRTPLVPLVLGGIAMVIAGYAAGAEGAAAALALTALAVPVWRLTRPVEDYLRDVTAGVFAAFYVPFLASFVALMLAADDDGPQRVLTFLILTVISDTGAYAVGYKLGRNKLAPRISPGKTREGLGGALAFAMAAGAVCMELLIDDGRWWQGLLLGAAAAASATLGDLAESMIKRDLGIKDMGTLLPGHGGIMDRLDSLLPTAPVVWLLMVIFVGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9C0</accession>
    <name>A0A0F7N9C0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_26160</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018371.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_26160"/>
    <dbReference type="EnsemblBacteria" id="AKH85130">
        <property type="protein sequence ID" value="AKH85130"/>
        <property type="gene ID" value="AA958_26160"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_26160"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5507"/>
    <dbReference type="OrthoDB" id="626204at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="62"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="273"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="309"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="338"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="363"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="410"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="483"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="20"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="509"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH85130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="537" mass="54376" checksum="F644F2B8451F35E7" modified="2015-07-22" version="1">MSAIAPEAPALRAGPRQWLGLAVLLAPTILLFVTMTVLFLATPDIAADLEPSSGQLLWINDIYGFMMAGLLVAMGTLGDRIGRRRILLFGAVAFGAASAAAAFAPSAEALIGARAVMGLGAAAVMPSTLSLISNMFQDAKQRATAIGLWAASVSVGVAVGPLVGGLLLENFWWGAALLAGAPVMGLVLLAAPFLVPEYRAPQPGRLDLPSVALSVVTILPIVYGVKEMAAHGVNAEAIVALVLGVVLSTVFVRRQLLLTDPLLDMRLFRNRTFSGSLAVFLLSAVALGGVYLLFTQYLQLVEGLTPLEAGLWILPAAVMLVVVSMLSPVIARRVRPGYVVAAGSLLSVAGYLVLTQVDSVGGLPLLITGFYLLYPGIAPVMALATNLVIGSAPPEKAGAASAVNSTASDLGVALGIALLGSVGTAVYRGEMADAVPAGVPEGADAAARDTLPGALSAAENLPAALGDAVLAPAKEAFASGLNVAAALAAGLAVAAAVLSATLLRRVPAAGAAQEEPDAAPEPPPARDETPVPAEAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9P6</accession>
    <name>A0A0F7N9P6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_20450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UbiD family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017453.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_20450"/>
    <dbReference type="EnsemblBacteria" id="AKH84164">
        <property type="protein sequence ID" value="AKH84164"/>
        <property type="gene ID" value="AA958_20450"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_20450"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4310"/>
    <dbReference type="OrthoDB" id="1012819at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022390">
        <property type="entry name" value="HBDC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002830">
        <property type="entry name" value="UbiD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30108">
        <property type="entry name" value="PTHR30108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01977">
        <property type="entry name" value="UbiD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03701">
        <property type="entry name" value="mena_SCO4490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00148">
        <property type="entry name" value="TIGR00148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="481" mass="52949" checksum="C3A5868D0508FD28" modified="2015-07-22" version="1">MAYDDLRSLLRALERDGDLKRITAEVDPYLEVGEITDRVNKAGGPALLFENVKGSAMPLAMNVYGTDRRLLKALGLGSYAEIGERIGGLLKPELPQGFTGVREAFGKLGTMAHVPPRKAKDGPVQETVLTGDDVDLDTIPALFTWPQDGGSFYNLGLTHTKDPETGVRNLGLYRLQRHDRRTIGMHWQIHKDSRNHYQVAARRGEKLPVAIAFGCPPAVTYAATAPLPGDMDEYMLAGFIGGKRVEMVDCKTVPLQVPAHAEVVLEGWLEPGKELPEGPFGDHTGFYTPQEPFPALTIDAVTMRRRPLLQSIVVGRPPTEDGPLGRATERFFLPLLKVIVPDIVDYHLPEAGGFHNCAIVSIDKKYPKHAQKVMSAIWGAHMMSLTKLIIVVDADCDVHDLHEVAWRALGNTDYSRDLSVVEGPVDHLDHASYQQFWGGKAGIDATAKLPEEGYTRGWPEMVVSDPDTAAKVDARWPEYGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NA05</accession>
    <name>A0A0F7NA05_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">DNA-directed RNA polymerase subunit alpha</fullName>
            <shortName evidence="11">RNAP subunit alpha</shortName>
            <ecNumber evidence="2 11">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">RNA polymerase subunit alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 11">Transcriptase subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">rpoA</name>
        <name evidence="13" type="ORF">AA958_21315</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 11">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.</text>
    </comment>
    <comment type="domain">
        <text evidence="11">The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the RNA polymerase alpha chain family.</text>
    </comment>
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        <property type="entry name" value="RBP11-like"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11 13" id="KW-0240">DNA-directed RNA polymerase</keyword>
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        <location>
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            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Alpha N-terminal domain (alpha-NTD)" evidence="11">
        <location>
            <begin position="1"/>
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            <begin position="238"/>
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    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AKH84314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="340" mass="36754" checksum="955DD862C0A4D380" modified="2015-07-22" version="1">MLIAQRPSLTEEVVEEYRSRFVIEPLEPGFGYTLGNSLRRTLLSSIPGAAVTNIRIDGVLHEFTTVPGVKEDVTDLILNIKQLVISSEHDEPVVMYLRKQGPGVVTAADIAPPAGVEVHNPDLVLATLNGKGKLEMELTVERGRGYVSAVQNKQVGQEIGRIPVDSIYSPVLKVSYKVEATRVEQRTDFDKLIVDIESKPCMRPRDAVASAGKTLVELFGLARELNIDAEGIDMGPSPTDAALAADLALPIEELELTVRSYNCLKREGIHSVGELVARSEADLLDIRNFGAKSIDEVKAKLAGMGLALKDSPPGFDPTSAADTFGADDDADAGFVETEQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NA30</accession>
    <name>A0A0F7NA30_9ACTN</name>
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        <submittedName>
            <fullName evidence="3">2-aminobenzoate-CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_27720</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
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        </lineage>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="48"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="449"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH85395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="545" mass="58867" checksum="17F8BB8F5DE4DFD6" modified="2015-07-22" version="1">MQLKPSAHADTFARDHLPPPGQWPDLVFPLPGLHYPDRLNCGAELLDATVERFGAGRPALHTAAGETWTYGELQRRTDRIAHVLTDDLGVLPGNRVLLRGPTTPWLVACWLAVMKAGAVAVTVLAAQRAHELRGICEIARIRHALCDARSLDDLTRAEVAGLTVVPYGGGEPGDLLRLADAKPDAYAPVETSVDDVALIAFTSGTTGRPKGCVHFHRDVLAIADTFSAHVLKPLPDDVFAGSPPLGFTFGLGGLVVFPMRAGASALLLEQAGPDRLLPAVAEHRVSVLFTAPTAYRAMLDKLGAYDTGSLRRCVSAGENLPAVTWQEWRERTGLRIINGIGATEMLHIFISAADDDARPGWTGVPVPGYEARVVDAAGTEVPDGEPGLLAVRGPTGCRYLADERQREYVRGGWNLTGDTYVREPDGYFRYVARADDMIISAGYNIAGPEVEDALLRHPDVREAAVVGRPDPERGTVVVAYAVLREGVVRGPETEAALREFTKGEITPYKCPKEILFTDALPRTPTGKLQRYRLREEQAGLAAGNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAK9</accession>
    <name>A0A0F7NAK9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_22610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017786.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_22610"/>
    <dbReference type="EnsemblBacteria" id="AKH84528">
        <property type="protein sequence ID" value="AKH84528"/>
        <property type="gene ID" value="AA958_22610"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_22610"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4757"/>
    <dbReference type="OrthoDB" id="1195369at2"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="220"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="276"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="318"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="360"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="390"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="439"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="675"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="723"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="765"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH84528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="798" mass="83562" checksum="76A370BAA61320BE" modified="2015-07-22" version="1">MSDVTYAEKKRGTRPPRSAGPPPPDPRGTLRVWADDLRMGLAFALRGGREGWMRTVLTAVGVGLGVALLLLTTAVPGALANRDERELARSEVLASDAEYGGGTLLMGNVDTEYEGTMVRGRLLRPEGPGAPLPPGLDAFPKPGEMVVSPALADRLDDGDADLLRERLDYGIAGTVADTGLSDPGELVYYAGSDAIEAADVNVSRIAAFGDDGDGGGMDPVLLLLAMIVFVALLMPVAVFLIAAVRFGGDRRDRRLAALRLVGADGHAVRRIAAGEALAGALLGLVVGAGLFLAGRQLAGAVSVYGMSVFTSDLNPSPALALLVAAAVPAAAVGVTLLALRGVVIEPLGVVRAARPRRRRIWWRLLLPALGLGLLAPMMGRGEDAGAFPEWQVIGGTVLLLTGITALLPWLVEAVVARLGRGPTSWQLAVRRLQLSSGTAARLVNGIAVAVAGAIALQMVFAGVEDDYSRPTGNDTSRYQLGIYVDAGQDLRVGDRVATAEGVRETVSRITVEVADTARDPENFATLTVGSCAKLRTLAKLPDCRDGDVFRLTDTYGSADVRRMIADGDPLYLNPSYEGMPGKALAWTPPTGTRPAKALRDGDGNLYDGIISTPGAVPDVHDSGVFNAWVDVRLDPAVPDAAERVRNVVDGLDPLLSVHTLSSEVVEEDFAGIRTGLAVGAACVLVLIGSSLLVGQLEQLRERRKLLSSLVAFGTRRSTLSLSVLWQTAIPVALGMTLSMGFGLVLGTVLLRMTATPVAVDWTSVLLMAGAGAGVVAAVTALSMPLLIRLMRPDGLRTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAL5</accession>
    <name>A0A0F7NAL5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_17725</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
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    </dbReference>
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            <end position="394"/>
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        <location>
            <begin position="454"/>
            <end position="479"/>
        </location>
    </feature>
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        <location>
            <begin position="486"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="535"/>
            <end position="553"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="AKH83742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="561" mass="58180" checksum="315D2AD7B2C1C9D2" modified="2015-07-22" version="1">MSATPSTTDDTAQGTKSRPVAPPRAADGGAALAGAGTLFRFALRRDRVRLPVWVLALFLGTASSVSSFDTSYDTAKKRADIAETMDSPAGLAMTGPRHYLDDYNIGSMTGHQMLGFTAVLVGIMSVLIISRHTRTEEETNRAELVRSGVVGRHSYLAAALGVAVVANVALGLLLAAGLSGMGVDGVDGQGALLYGLAHTAVGIFFAAVAAITVQVTAYARGASGMAMAVIGAAYALRAAGDVGSDWVSWLSPIGWVQRTYVFVDNRWWPLLLVLAAAVVCAAAGFFLSTRRDVGAGLRAARLGSPAGSEGLTTPLGFALRLHRGLLAGFGAGALLLGVMYGSILGDAEEMIEGIDELEEQLAEIGGANVAESFASVVMIVLAVVCSIYVVMAALRPRAEESAGRAEPLLSTALSRDRWVLSHAFVGAAGGTALILLAGIGFGASGAASTGDGGLFLKLVGAALAFAPALWVTIGLAVALFGWFPRAVAVAWVVPVYGFVVDYLGEILKFPDVLSDLSPFGHIPQLPAQDMSWPPLLVLTAIAVGLVWLGLLGFRRRDLETK</sequence>
</entry>
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    <accession>A0A0F7NAL9</accession>
    <name>A0A0F7NAL9_9ACTN</name>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
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            <taxon>Streptomycetaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="67" mass="7171" checksum="9FDDDBC83FC50236" modified="2015-07-22" version="1">MNAILDYTVGTLVLLLMAAILAGPALYFDRRERLTDRRLKAAERGAGPAPAGNVSVRDALARYGRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAM9</accession>
    <name>A0A0F7NAM9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease</fullName>
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    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_26135</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
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        <property type="protein sequence ID" value="AKH85126.1"/>
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    <dbReference type="EnsemblBacteria" id="AKH85126">
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        <property type="gene ID" value="AA958_26135"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_26135"/>
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    <dbReference type="OrthoDB" id="1264541at2"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="P:transmembrane transport"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="TM_PBP2"/>
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    </dbReference>
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        <property type="entry name" value="MetI-like"/>
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        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
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        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ABC_TM1"/>
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    </dbReference>
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            <begin position="7"/>
            <end position="32"/>
        </location>
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        <location>
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        </location>
    </feature>
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        <location>
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        </location>
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            <begin position="64"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH85126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="263" mass="28109" checksum="75394822AAFCE3E9" modified="2015-07-22" version="1">MRWIRRHLVVIAGTLALVYLLLPNVVVLVFSFNDPAGRYNYTWQSFSTDAWTDPCGVAGMCDSVGLSLRIALAATVAATVIGTLAAFALARHRFRGRAAGNSLIFLPMAMPEVVMAASLGTLFLNMRVEFGVTTILIAHIMFCLSFVVVAVKARVASMDPKLEEAARDLYAGPLQTFLRVTLPLAAPGIAAGAMLSFAISLDDFIITQFNAGPSTVTFPMYVWGASQRGIPVQVNVIGTAMFVAALALVVAGQVVGARRRSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-12-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NB28</accession>
    <name>A0A0F7NB28_9ACTN</name>
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        <submittedName>
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        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">AA958_27345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH85331">
        <property type="protein sequence ID" value="AKH85331"/>
        <property type="gene ID" value="AA958_27345"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_27345"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5762"/>
    <dbReference type="OrthoDB" id="1775418at2"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Chorismate_lyase_/UTRA_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
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        <property type="entry name" value="UTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
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        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
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        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07702">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00866">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64288">
        <property type="entry name" value="SSF64288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="11"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="259" mass="28582" checksum="54A53C9D55C51EEE" modified="2015-07-22" version="1">MQSSIDRSSLLPFYHQLKQILLGEMESRELKPGDRLPGDHELCERYGVSRTVVRQALAELESEGVIERIKGRGTFVAHPKTPEGLVQSLTGLYEDVAARGGHLRSQVRRLEVVPADAQVAGALDVPPGHPVIVIERLRFVEEEPWVLTITHVPQEVAPGLVDEDLTQESLYALLEGRFGVRLVQGRRSVEAAVASTELARSLGVNRGAPVLVLRSVSVGEQGRPVESFVAFHRGDRSRFEVELSRRQGAPPRPLMIVTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NB52</accession>
    <name>A0A0F7NB52_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6431 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_18835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017209.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH83912">
        <property type="protein sequence ID" value="AKH83912"/>
        <property type="gene ID" value="AA958_18835"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_18835"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3955"/>
    <dbReference type="OrthoDB" id="2036218at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045536">
        <property type="entry name" value="DUF6431"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20020">
        <property type="entry name" value="DUF6431"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6431" evidence="1">
        <location>
            <begin position="21"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="191" mass="20606" checksum="D11621DFD8E87023" modified="2015-07-22" version="1">MIEVADAAAARHALARRRLHCPDCDAAVKSWGQARARTVRDLGGELVTVRPDRARCTGCLRTHVVLDARLLPLRAYTVRFVGQALVGAVRGHGHRQIAAELGAPATTVRGWLRRARRNAEQLRCLGAQAVVALDPDALPTTDRGDPLAHAVEALVAAAVAAYRRFGHGPREVWARITLLTHGRLLAPRPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NB55</accession>
    <name>A0A0F7NB55_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_23560</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017944.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH84689">
        <property type="protein sequence ID" value="AKH84689"/>
        <property type="gene ID" value="AA958_23560"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_23560"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4966"/>
    <dbReference type="OrthoDB" id="2014094at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="7"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="72"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH84689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="136" mass="14604" checksum="FDEE5927C6EC2961" modified="2015-07-22" version="1">MLVRDAMSTVVLTIGPAHTLRQAARLMSARRVGAAIVFDPDTSGLGILTERDILNSVGAGQDPDTEKADDHTTTDVVFAAPGWTLDDAADAMTHGNFRHLIVLDDAEPVGVVSVRDIIRCWTPARQASERRETALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBC2</accession>
    <name>A0A0F7NBC2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_27795</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018640.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_27795"/>
    <dbReference type="EnsemblBacteria" id="AKH85406">
        <property type="protein sequence ID" value="AKH85406"/>
        <property type="gene ID" value="AA958_27795"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_27795"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5859"/>
    <dbReference type="OrthoDB" id="1584669at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="41"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="139"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="216"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="280"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="104"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH85406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="312" mass="34321" checksum="2250F976030D47A2" modified="2015-07-22" version="1">MTTAEPTDTPRAAEAPTAGDPKAKKPSSPLLKPERSIEGTVLNVFSHGFLILWAVLAAGPLLWALMTAFKPSASILESPWGLPDGLHWENWSNAWSNANIGRYTLNSFVIVIFSVPLTMLFGSMAAYVLARFDFRGSRIVYFTFVGGMAFPVVMALVPLFFVMKNLALLDTRHGLIMVYIAYSMPFTIFFMTTFFRTLPSSVAEAAEIDGASHSRIFFQVMLPMAKPGLISVGIFNFLGHWNQYVLPFALNQGDEDDYVLTQGIGFLFAQAGYRADYGRLFAGLMMAALPILIVYAIFQRQVQAGLTAGAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBD6</accession>
    <name>A0A0F7NBD6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_30445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019048.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_30445"/>
    <dbReference type="EnsemblBacteria" id="AKH85820">
        <property type="protein sequence ID" value="AKH85820"/>
        <property type="gene ID" value="AA958_30445"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_30445"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6434"/>
    <dbReference type="OrthoDB" id="1919368at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="389"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="450" mass="46520" checksum="8E30EC5D6D7E2D68" modified="2015-07-22" version="1">MGLREALRRTGTRHPAVLLAVHPGGTETRLAVEAGLRRRGWPVAASPAAASGLLVVGAGGAGAGEWTDALWRQIPYPKSRSTVTGAEGVETALDGLLRTLAAPAGGSGGGVAGEVGPGEGAAGRRPGAGHAAHQDHGTHEGPRGGEDNRGHGGEPGHEGHTGHESADGHDAHEPPGGHGAHDAHAAHLGHAGPVAGLPMAERADDRDGLRLDRLHLPLGPGLADWPAGLVLDVALQGDVVQHAGVRTATPAAEELPYWDEPWLRAARGEDVVRGAAHRRCCAAHLDSIARLLAVSGWPDPAARARRLRDAVLDGVPARVWSAGLERLGRRVRRSRVLRASTAGLGALPAARARRSGVTGPALAADGDAYDRLLTWLDEAARHAAGVDDDRPLARYGQDGPRGRLDGPRPPSRALLDVLPDLLRGAEFTSARVIVASLDPDLDELAVAVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBE9</accession>
    <name>A0A0F7NBE9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_19675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017319.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_19675"/>
    <dbReference type="EnsemblBacteria" id="AKH84027">
        <property type="protein sequence ID" value="AKH84027"/>
        <property type="gene ID" value="AA958_19675"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_19675"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4146"/>
    <dbReference type="OrthoDB" id="831053at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="10"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="329" mass="34249" checksum="764BD375D85390D5" modified="2015-07-22" version="1">MHAIRLHAFGPPENLVYEKTEDPVPGPGQVRIAVAAAGVHLLDTFLRAGGTGGPMPPPDLPTIPGREVAGTVESVGDGVDPEWLGRRVVAHIGLRPGGYAELTVTEAERLHALPDSLGAAEAVAMIGTGRTTMGFLHFAEVTADDVVIVTAAAGGVGSLLVQYARNVGAYAVGLAGGPEKVARVRDLGADAAADYTEQDWPDAVRAALGDRRPTVLLDTVGGAAARTAADFLAPGGRHLVLGWSSGTPLEFTEAELAERGITSVNVLGPDWLSRIGGDDPLRRMEEAALTEAATGRWTPLVQRYPLARAAEAHRALETRGTVGKVVLEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBF1</accession>
    <name>A0A0F7NBF1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Polysaccharide pyruvyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_27995</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018675.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_27995"/>
    <dbReference type="EnsemblBacteria" id="AKH85441">
        <property type="protein sequence ID" value="AKH85441"/>
        <property type="gene ID" value="AA958_27995"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_27995"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5900"/>
    <dbReference type="OrthoDB" id="59861at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007345">
        <property type="entry name" value="Polysacch_pyruvyl_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04230">
        <property type="entry name" value="PS_pyruv_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PS_pyruv_trans" evidence="2">
        <location>
            <begin position="386"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH85441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="690" mass="75302" checksum="790BE58CDAF89988" modified="2015-07-22" version="1">MIPSSPRSPAGAPASPAPRALPGPVPPLAAGAGRPAPAVAAAARRAPRVAFVCRADAADPGHAAGLPALLRSLALANPGVCEDFLLRHDGLPDDVLAAARRLHPRIVELPAGGGEAGAAPDPYDDLTGAYDDLIELHPRWLVAADLAVLRDPSDETRARYELTDERFWRAYCTLPAHRQHPDLLLHYGPPLLRLRPTTDLARRTALGLRTIGAYEEAVEALSTARSQANQPRFHDAMGTALMAVSRYDEAETHLLLAAAAPELAPKAFSQLARLAWMRGDEERSKAYAREGLDAEPTNRTCKALLQGGYGLPEFAAHRGEASVVSTQLAHAAAYATGQENAGDKILPEAVRLCFGQDASARRWHPVPVHRLFDEEALAEVNARRGLVVGGGGLFLPDTWPNGNSAWQWNVPDELLARIDVPLAVFAVGYNVFPGQSYRRSRFRESLAALVDRSAFFGLRNRGSVERVRELLPERLRERVAYQPCPTTLTRLLQPGWDDGEVERADTVLVNCAYDRAGMRFGDGYPRFLDAMARAVRALRERVDVRVAAHMTADEQFAHDLRREHGITLPVDALYDLGNDAIRAAYRRTRLVIGMRGHAGMIPFGCGTPVLSLVSHPKLAYFLADIDRPEWGVRVDDERLAEVLVERAEAVLDDHGAAVADVLDRQRVLWKVTRENLAELRPALGLQGGTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBG0</accession>
    <name>A0A0F7NBG0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aromatic ring hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_24210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018056.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_24210"/>
    <dbReference type="EnsemblBacteria" id="AKH84804">
        <property type="protein sequence ID" value="AKH84804"/>
        <property type="gene ID" value="AA958_24210"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_24210"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5102"/>
    <dbReference type="OrthoDB" id="867226at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="5"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="591" mass="64009" checksum="DD65E5722541BF1D" modified="2015-07-22" version="1">MEAIEVPVLIVGGGGCGLSASIFLSGQGVEHLLVERHTDTSRLPRAHYLNQRTMDIFRQHGLVDSVHELSAPPEVFGRVRWQTSLAGDDPLDGQVIYEMDAFGGGALTEVYAEHGPVLPAKLPQLRLEPMLRRRAERDNPGRVLFGHELTTFSDKGDRVVAEIRDIATGETTTVTAQYVIAADGGRTIGAELGVEMQGVPSMLNVTTAYLTADLSPWWHDGTIITWFVNPFRPDLSSTLMEMGPTWGKHCEEWALHFNPGDADRDDPEAMTARIREVLGVPDLELTLHRISQWTVEGVLADRYRQGRVLIVGDAAHRQPPTTGLGLNGGVQDVHNLAWKLAAVVAGHADDSLLDSYETERRAVGKRNVDWGLSTWFHHKVVTEAAIGLGAHIPVERRSAVFSAYFDPSPVGTAVRARAAEIFQTHRSECQAHDLEVGFAYEDGALVPDGTAPPARAPLGNTYHPTTRPGHMLPHAWIERDGERLSTHDLVGRGGGFVLIAGPEGKAWCDAAAEAAEKFSIPLTAVRIGEGAEYAAADGRWAAVREITDEGAILVRPDHHVAWRSTSAGADPAAALADVLSRVLAHGGTRHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBN2</accession>
    <name>A0A0F7NBN2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MDMPI_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_24450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AHA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018091.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_24450"/>
    <dbReference type="EnsemblBacteria" id="AKH84839">
        <property type="protein sequence ID" value="AKH84839"/>
        <property type="gene ID" value="AA958_24450"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_24450"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5152"/>
    <dbReference type="OrthoDB" id="1805421at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013538">
        <property type="entry name" value="Activator_of_Hsp90_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017517">
        <property type="entry name" value="CHP03083_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017520">
        <property type="entry name" value="CHP03086"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024344">
        <property type="entry name" value="MDMPI_metal-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08327">
        <property type="entry name" value="AHSA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11716">
        <property type="entry name" value="MDMPI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03083">
        <property type="entry name" value="TIGR03083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03086">
        <property type="entry name" value="TIGR03086"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MDMPI_N" evidence="2">
        <location>
            <begin position="172"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH84839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="346" mass="38028" checksum="B6E32570E4CC993A" modified="2015-07-22" version="1">MSTTPTRHRNETGIVVDPALPTIVITREFEAPPERVFRAHTDPDLVAQWLGPRGLTMTIDRYDARTDGSYRYVHADEEGNEYAFHGVFHEVRPAERIVQTFTYEGMPDSVSLETAVFEDLGGRTRLTATSLLDSLESRDGMIASGAETGIREGYERLDAVLDGTQAAEEHRRIAAGFTARVRGAEAGRWDDPAPCEGWVARDVVRHLVEWFPGFLKTGAGIELPEGPSVDDDPVAAWQVHNDAVQSLLDDPATAGRTLSHPQTGDLPLAQAIDRFYTSDVFMHTWDLARATGQDEHLDPAKCAALLAGMLPMDEVLRGSGHYGPRVEVPESADVQTRLLAFTGRTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBW5</accession>
    <name>A0A0F7NBW5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AA958_29560</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="gene ID" value="AA958_29560"/>
    </dbReference>
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    <dbReference type="PATRIC" id="fig|444103.5.peg.6238"/>
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    </dbReference>
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            <end position="192"/>
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        <source>
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</entry>
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
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            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="117" mass="12576" checksum="4580BEA0AAF5E7D3" modified="2015-07-22" version="1">MKEADHEWHDDGPERLYVITGGRSGTAAQGALDLVTLVISRTQPAPGMQPERAAIVRLCRAPLSVAELTAYLRLPFSAVAVLVADLMAEGAVETRSTVPPVADLRLLEEVMDGLEQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCF4</accession>
    <name>A0A0F7NCF4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">AA958_26285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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                <person name="Albersmeier A."/>
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                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
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        <property type="gene ID" value="AA958_26285"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_26285"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5534"/>
    <dbReference type="OrthoDB" id="2089702at2"/>
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    </dbReference>
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            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="173" mass="16905" checksum="1F6B22CBDA59777D" modified="2015-07-22" version="1">MLAGAALLAATGTTAGCSGDGGGDGDPDPARTERLRRRAADESRLLLRRYDATTAAHPGVADALAPLRAEVAQHVAALARGLPADTRAASPEGGAEGSGDRADAAPPPPGKKRGGEPVAAEPARAVAELAALEKRTADAHTAALATAPGELAGLLASVAAAGAAHVYLLGAMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCF8</accession>
    <name>A0A0F7NCF8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Signal peptidase I</fullName>
            <ecNumber evidence="3 5">3.4.21.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_25945</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.</text>
            <dbReference type="EC" id="3.4.21.89"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Membrane</location>
            <topology evidence="5">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the peptidase S26 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.89" evidence="3 5"/>
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        <property type="protein sequence ID" value="AKH85093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018334.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_25945"/>
    <dbReference type="EnsemblBacteria" id="AKH85093">
        <property type="protein sequence ID" value="AKH85093"/>
        <property type="gene ID" value="AA958_25945"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_25945"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5463"/>
    <dbReference type="OrthoDB" id="1741894at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000223">
        <property type="entry name" value="Pept_S26A_signal_pept_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019758">
        <property type="entry name" value="Pept_S26A_signal_pept_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43390">
        <property type="entry name" value="PTHR43390"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00727">
        <property type="entry name" value="LEADERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02227">
        <property type="entry name" value="sigpep_I_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00761">
        <property type="entry name" value="SPASE_I_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S26" evidence="7">
        <location>
            <begin position="33"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600223-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH85093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="240" mass="25408" checksum="52B25153D9879D3B" modified="2015-07-22" version="1">MDTELRPEERDDSSSPESGREGSSRSSFLRLLRWAVALAATFTVLGLLVSAFVVQPFLVPSSSMEPVLQPGDRVLVNKLAYAFGDEPERGDVVVFDGSGTFAAAGDGGGAVPGLLRRAGAATGLAEPEGTDYVKRVIGVGGDRVICCDARGRVKVNGKPLDEREYLYPGDAPSLVEFDVIVPPGRLWVMGDHRSDSRDSRDHLGSPGGGTISVDKVIGRADWRGWPPDRAGSLGRPGYGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCM0</accession>
    <name>A0A0F7NCM0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PKS_KS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_31230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_31230"/>
    <dbReference type="EnsemblBacteria" id="AKH85946">
        <property type="protein sequence ID" value="AKH85946"/>
        <property type="gene ID" value="AA958_31230"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_31230"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6599"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_KS" evidence="1">
        <location>
            <begin position="63"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="346" mass="35840" checksum="0F2299FC10325F81" modified="2015-07-22" version="1">MADGTGGGAPRPPRYRVEAAAADRAAAEAAAAELRARGLDAAVRTAGSLPSLTAGAPAGPGAIVAVGMGLAVPGACSPDELWDLLRDRVPQFSEPGGRMDIDALWSADPAAPDKTYTRTSGFIHDLRPHPRLRAELAAGRAPQREPSGLWLRHSVLQALDGVRLDAGTRTFAAVGMTADGGHAAEHSLLRHGTRLLAGPAAADPEPLAALYPAGSPDLAGTAPYRVVRDALAGIADPVETVVVDTACSSSLYSFDFGMRALREGRADVALCGGAYSVNAQTMVLFAKLDGLARGGLVRSLDRGADGACRAAGGTPRRLWPHDDAELSAADGVYARLRLRRVRETPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCP8</accession>
    <name>A0A0F7NCP8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bicyclomycin resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_31405</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019204.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_31405"/>
    <dbReference type="EnsemblBacteria" id="AKH85976">
        <property type="protein sequence ID" value="AKH85976"/>
        <property type="gene ID" value="AA958_31405"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_31405"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6636"/>
    <dbReference type="OrthoDB" id="447734at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519366" evidence="2">
        <location>
            <begin position="27"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="441"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH85976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="467" mass="49831" checksum="34E80BB909F33A63" modified="2015-07-22" version="1">MRTWTRRSRISALLASTLAMGVLAGCATGTSGPGTPDRKITVWSEESLTDRIASTQKVIDRFEDETGVEVELVGVDENQLPQLIMSAAAAGDLPDVIGAVPLGQAWQMYSNELLNTRIPAEVVDRLGEDTFDANGLRLTADGGTRLGVPSDAWVQIVAYRQDLFREAGLDVPDDYASLLKAAETLDVKGRDGISVATDPADVFTQQSFEDLALANGCDLVDGDGGIGLDSERCRTAFEAYDSLARRYGPPGLQTVDTTRATYFAGQSSMIIWSSFLLDELAGLRNDAMPSCAECKDDPGFLAANSGIVTSLQGPGGTEPAQFGEITSWLATKTAETEASTRFIEYMMGAGYEDWFGMAPEGKIPVRTGTPGQPERYLDAWRASDMGVDTRKSMEEVFSPELLDQLVAGVGDMKRWGIDQGEGALVGATNGELPVAKAVGAMTSGQTSPGEAAREAYEEVDALKTSLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7ND51</accession>
    <name>A0A0F7ND51_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sulfatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_27550</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="PTM">
        <text evidence="3">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018598.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_27550"/>
    <dbReference type="EnsemblBacteria" id="AKH85364">
        <property type="protein sequence ID" value="AKH85364"/>
        <property type="gene ID" value="AA958_27550"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_27550"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5805"/>
    <dbReference type="OrthoDB" id="1067869at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032506">
        <property type="entry name" value="DUF4976"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16347">
        <property type="entry name" value="DUF4976"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase" evidence="4">
        <location>
            <begin position="2"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4976" evidence="5">
        <location>
            <begin position="367"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="3">
        <location>
            <position position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600917-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH85364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="489" mass="55479" checksum="F10B7A89541BAAFB" modified="2015-07-22" version="1">MNLLFFMTDQHRVDTLGCYGNPHVATPHLDRLAATGTRFERCYTPTAICTPARASLLTGQAPFRHRLLANYERNVGYLEDLRDDAFTFPGALAARDYQLGLIGKWHGGTHRNAASYGFEGPDLPGWHNPVDHPDYLAYLDERGLPPYRISEPIRGTTPNGNPGNLLAARLHQPAGATFEHYLATRAIEHLDAYAATGRPFFLATHFFGPHLPYLLPDEYYDMYDPDLVELPPSIAETFEGKPAVQRNYSAHWTFDTLPLEVTRKLIAVYWGYVTLIDRQIGRILARLDELGLTDETAVFFTADHGEFTGAHRLHDKGPAMYEDIYRIPGIVRVPGAPPQVRDEFVTLTDCTATILDLAGCDTAPAVDSRSLLPLVRGERPEWPAELLAEFHGHHFPYPQRMIRDERYKLVVNPESVNELYDLHADPHELTNRYAHPEMLPVRRGLLRRLYDLLRERGDNFYHWMTPMYDVGDLDYDPTLSAFEPEGTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7ND86</accession>
    <name>A0A0F7ND86_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AA958_32760</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019428.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_32760"/>
    <dbReference type="EnsemblBacteria" id="AKH86201">
        <property type="protein sequence ID" value="AKH86201"/>
        <property type="gene ID" value="AA958_32760"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_32760"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6921"/>
    <dbReference type="OrthoDB" id="1236682at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0274">FAD</keyword>
    <keyword evidence="2 4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="314"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="8">
        <location>
            <begin position="180"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="7">
        <location>
            <begin position="303"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="22"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH86201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="469" mass="48530" checksum="B55356936C5A2C6F" modified="2015-07-22" version="1">MTPPRAASAPAGSARPGAAPARPARELPPPGGPYVPSPELRAVLARHPALADFAARVTDFLDRHLPEPVTEEAPRPPWLELRGHAARAGLTGFDVAARGGGGDAADGAGHAPGGGRGAAVPPGLERVAQGLAMYLAGRRDCDAREVFSSGHGAMALRYGPPAVAHAVRDRVVERGELAGVASSEPHSGSDLRGLRTVAVDHGDHLVVSGTKGLVSRVEEAVGFVVFCKVVAPEQAAALTAEGADAGDRAALREVPLSALWLPMDAPGVRTQTAAPLGLRGWSLGHLHFDGVRVGRDLLLGAPGDGRRIFDAHFAGWRLMMALVCLGAAGAAIDEAMARTRRQSVGRTSLASIPSVASRLGTAAAEVQAATAWCFSLLEGLDRDADGAGVAACSAAKALATDASYRAVDLGLQLHGSDGYTCHTPMEKRLRDIRGLRIADGPNDVLYSVLAHALLEGPRAGVRVVRQRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDA4</accession>
    <name>A0A0F7NDA4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AA958_32915</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019453.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_32915"/>
    <dbReference type="EnsemblBacteria" id="AKH86226">
        <property type="protein sequence ID" value="AKH86226"/>
        <property type="gene ID" value="AA958_32915"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_32915"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6955"/>
    <dbReference type="OrthoDB" id="760677at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="6"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="146"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="256"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH86226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="417" mass="45702" checksum="93A997715B1D721F" modified="2015-07-22" version="1">MNWADTPEQAAFREEVRAFVRDRFPPAYVPDPEAEQSLEPEDVWGYNWPVDRLSDDPARREGARAWAAALAERGWIAPHWPAEYGGAGLPALEEFVLQEEMMRARVPTVNGIGAFLLGPTLLEHGTAAQRAAHLPPIARGEVTWAQGFSEPGSGSDLASLRTRAVREGDEATGTYTVNGQKVWTSLGQYADWLFVLVRTDPEAAKPHRGITFLLIDATAPGVTIRPITDIRGAAPFCEIFFEDVRVPAADRVGEENRGWYVAMTALSFERAGIGATIKYEQALSELVGYVGSDEGRAYLRADTGAALRREIARRHTEIRVQYNLARYTVSKQAAGGVPGYEASVNQLFGAELHQRLARTGAAAFGRSAQLWQRRDAPLGGVFTHMSRDSVASTFLGGASEIQRDVIATRGLNLPRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDB5</accession>
    <name>A0A0F7NDB5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_01310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019701.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_01310"/>
    <dbReference type="EnsemblBacteria" id="AKH86480">
        <property type="protein sequence ID" value="AKH86480"/>
        <property type="gene ID" value="AA958_01310"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_01310"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.290"/>
    <dbReference type="OrthoDB" id="1928091at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="307" mass="32415" checksum="4DDE58F01BD50C3B" modified="2015-07-22" version="1">MRIFITGASGYIGGSVSARLLQARHEVIGLARTEDRAKALRAGGITPVLGTLDDHEVLARAAHEADAVINAADSDHRGAVEALTDALAGTGKPFLHASGSSIVGDDARGEAAEQTFTEAAVSPAGPWRPAPDKAPRVAIDRLVLAAAERGVRSTVLCSSLIYGHGYGIARDSVQLPRLVDQARKSGVVRYIGTGGNIWSTVHIDDVVDLYVLALESAPPGSFYFAENGEASFAAMAQAIADTLGLGTAQPWDIDAAIQEWGYEPAVYALGSNSRVRGTRARDQLGWKPAHDSVTDWIRRRLTVSEPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDD1</accession>
    <name>A0A0F7NDD1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase M23</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_27595</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018607.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_27595"/>
    <dbReference type="EnsemblBacteria" id="AKH85373">
        <property type="protein sequence ID" value="AKH85373"/>
        <property type="gene ID" value="AA958_27595"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_27595"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5815"/>
    <dbReference type="OrthoDB" id="1891666at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519387" evidence="2">
        <location>
            <begin position="42"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M23" evidence="3">
        <location>
            <begin position="83"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH85373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="275" mass="29121" checksum="9377746DECF4BE73" modified="2015-07-22" version="1">MPRRPLHSSAPARRPARRAAAAVVAALLALLGLTAAVPAQADTGPELAPNFKAPFPCGQQWTYSHHSAEVRRALDFIRSDGGTTAGTPQVASAAGTATRHSQPSGAGNYIVIDHGGGWKTYYFHLASFSVANGQSVAQGQQIGITGSTGNSSGAHIHYEQLLNGVGQDIRINGSALPYPGSYGQYHLRSDNCGNTNFTTWGSGVRVRADARLSAPVVTTLSGPTSVFVECQKRGDVVNAEGYTNDWWSRLRDQRGFISNIYIDHPAAQLPGVPLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDF9</accession>
    <name>A0A0F7NDF9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_28120</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_28120"/>
    <dbReference type="EnsemblBacteria" id="AKH85459">
        <property type="protein sequence ID" value="AKH85459"/>
        <property type="gene ID" value="AA958_28120"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_28120"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5926"/>
    <dbReference type="OrthoDB" id="1832232at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="22"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="56"/>
            <end position="63"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH85459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="269" mass="29233" checksum="FDBEF67E74CD511D" modified="2015-07-22" version="1">MPQLEEKKTAATDAAASASIDIREVTCTFTTKRSRTTAVDGVSMRIEPGEFVSILGPSGCGKSTLLKMIAGLVLPTTGQVSLLGRQVTGPQRNIGFAFQRAALLQWRGARKNILLQAEMRGMDKQTAARRADELIELTGLKGFEEALPHELSGGMQQRVALCRALLHEPPVLLLDEPFGALDALTREHLNVELNRIWRETGTTIVLVTHSISEAVYLGTRVEVMSARPGRIIETMPVDLPPARDYGKVMSAPEFETLAARIRGLLGGAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDL2</accession>
    <name>A0A0F7NDL2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Assimilatory sulfite reductase (ferredoxin)</fullName>
            <ecNumber evidence="3">1.8.7.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AA958_28140</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the reduction of sulfite to sulfide, a step in the biosynthesis of sulfur-containing amino acids and cofactors.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3 H2O + hydrogen sulfide + 6 oxidized [2Fe-2S]-[ferredoxin] = 7 H(+) + 6 reduced [2Fe-2S]-[ferredoxin] + sulfite</text>
            <dbReference type="Rhea" id="RHEA:23132"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="EC" id="1.8.7.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="1.8.7.1" evidence="3"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018697.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_28140"/>
    <dbReference type="EnsemblBacteria" id="AKH85463">
        <property type="protein sequence ID" value="AKH85463"/>
        <property type="gene ID" value="AA958_28140"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_28140"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5931"/>
    <dbReference type="OrthoDB" id="1588103at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050311">
        <property type="term" value="F:sulfite reductase (ferredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005117">
        <property type="entry name" value="NiRdtase/SiRdtase_haem-b_fer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036136">
        <property type="entry name" value="Nit/Sulf_reduc_fer-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006067">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006066">
        <property type="entry name" value="NO2/SO3_Rdtase_FeS/sirohaem_BS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01077">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03460">
        <property type="entry name" value="NIR_SIR_ferr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00397">
        <property type="entry name" value="SIROHAEM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55124">
        <property type="entry name" value="SSF55124"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56014">
        <property type="entry name" value="SSF56014"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00365">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0883">Thioether bond</keyword>
    <feature type="domain" description="NIR_SIR_ferr" evidence="9">
        <location>
            <begin position="101"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="NIR_SIR" evidence="8">
        <location>
            <begin position="172"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="NIR_SIR_ferr" evidence="9">
        <location>
            <begin position="348"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="NIR_SIR" evidence="8">
        <location>
            <begin position="425"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AKH85463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="564" mass="62632" checksum="C686121D4654DABE" modified="2015-07-22" version="1">MANSSSRPTAAGRRKAGRHRGEGQWAAGHFTPLNGNEQIKKDDDGLNVRTRIETIYSKRGFDSIDPADLRGRMRWWGLYTQRKPGIDGGKTAVLEPHELDDEHFMLRVRVDGGRLTVTQLRTIGEISQEFARGTADLTDRQNIQLHWIRIEDVPEIWRRLESVGLSTTEACGDVPRVVLGSPVAGIAADEIIDGTPALEEIQRRVVGNPAYSNLPRKFKGAISGSRQLDIVHEINDVAFVGVEHPELGPGFDVWVGGGLSTNPKLGVRIGAWASLEDVPDVFEGVVAIFRDYGYRRLRNRARLKYLLADWGPSRFRQVLQDEYLLRTLPDGPPPAAPAERWRDHIGVHRQHDGRYYLGFAARVGRVDGGTLTKIAELAAEHGSDRLRTTVEQKMLILDVEEDRVEPLREALAALDLQVEPSPFRRGTMACTGIEFCKLAIVETKARGASLVDELERRLPGFDEPITINLNGCPNSCARIQVADIGLKGQLVTDEDGRQVEGYQVHLGGSLGMDPGFGRKVRGLKVTAAQLPEYVERVLTRYTAGREEGERFAQWAARAGEEDLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDN4</accession>
    <name>A0A0F7NDN4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Inositol-phosphate phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_28580</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a myo-inositol phosphate + H2O = myo-inositol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:24056"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:84139"/>
            <dbReference type="EC" id="3.1.3.25"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.1.3.25" evidence="2"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018778.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_28580"/>
    <dbReference type="EnsemblBacteria" id="AKH85544">
        <property type="protein sequence ID" value="AKH85544"/>
        <property type="gene ID" value="AA958_28580"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_28580"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6021"/>
    <dbReference type="OrthoDB" id="1741160at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008934">
        <property type="term" value="F:inositol monophosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052832">
        <property type="term" value="F:inositol monophosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052833">
        <property type="term" value="F:inositol monophosphate 4-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046855">
        <property type="term" value="P:inositol phosphate dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020583">
        <property type="entry name" value="Inositol_monoP_metal-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020550">
        <property type="entry name" value="Inositol_monophosphatase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00377">
        <property type="entry name" value="IMPHPHTASES"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00629">
        <property type="entry name" value="IMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00630">
        <property type="entry name" value="IMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH85544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="286" mass="30186" checksum="3DD5B4DBA13750CF" modified="2015-07-22" version="1">MIDDFLASADALDRVEDALRKAAAEEVMPRFRQLRADEIVQKDGPHDLVTVADRNAEVHLERSLTALLPGSVLVGEEGTHADRGRLAALREDAPVWIVDPVDGTRQFVRGEPGFCMLVALAHRGEVLASWTYLPAKDLMAVARRGGGAHLVGGEELRSGVPEPGQELHVAVSHHDFTTDAEKRALARLDVPGVRARPCGSAGHDYLSVARGEIDAVAFSWEKPWDHAAGLLLVAEAGGASGTVAGEPFRVAGGNALPFTAARDAETARHILALLAGPGRGVPGAGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDR3</accession>
    <name>A0A0F7NDR3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Beta-lactamase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_28515</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="protein sequence ID" value="AKH85533"/>
        <property type="gene ID" value="AA958_28515"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_28515"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6008"/>
    <dbReference type="OrthoDB" id="767622at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH85533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="214" mass="22732" checksum="9AC943A5951B39B1" modified="2015-07-22" version="1">MELTKKGHSCVRLAKDGAVLVIDPGGYSEPDAAVGADALLVTHEHPDHFDEGRLRAALDTNPAAQLWTLRSVAEQVSAAFPGRVHTVGEGDVVTAAGFEVEVHGQLHAVIHPDIPRITNVGYVVDGAVFHPGDALTVPDRTVETLLLPVMAPWNKVAEVIDYVRAVAPRRAVDVHDALLSDLAPQLYGRMLGPNGPGLAGAEHLHLERGTTLTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDV2</accession>
    <name>A0A0F7NDV2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_29135</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_29135"/>
    <dbReference type="EnsemblBacteria" id="AKH85634">
        <property type="protein sequence ID" value="AKH85634"/>
        <property type="gene ID" value="AA958_29135"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_29135"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6140"/>
    <dbReference type="OrthoDB" id="1167152at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH85634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="266" mass="28041" checksum="3D7BC5A771FED71B" modified="2015-07-22" version="1">MTTAAAAAGPIGTPHDGLVPQLHGLHAVVFDTDEIITDSAPVHAAAWKAAFDAVLHARPPADPALRGTFDPVGDYRRHVDGKHRIDGATDFLTTRGMTLPLGTPRDAPGTDSVWAVVAAKEAAFTARLDEHRVEAYPGAVHLLDRLRRADVPCAAVSASRHTRDLLLRAGVRAYFACLVDGRDTAHLDLKDAPAPDLFLEAARRLAVEPSAAAVVGFAFAGVEAGRRGGFALVVGVDRTGTEASATELRRHGADVVVHDLAELLDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDV7</accession>
    <name>A0A0F7NDV7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_29165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018868.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_29165"/>
    <dbReference type="EnsemblBacteria" id="AKH85639">
        <property type="protein sequence ID" value="AKH85639"/>
        <property type="gene ID" value="AA958_29165"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_29165"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6149"/>
    <dbReference type="OrthoDB" id="865015at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="112" mass="11837" checksum="D2E039E3870AAA9A" modified="2015-07-22" version="1">MPADWIGTRLLFTHGFGPTVAQNAPNPAVRDHLRAGGHALAGSSSDPERHTSRHEGVDCACLLAGSTHAPQVRVRYRAAPGPDPDGAAYVPYRPAELVVGRDIGREKGGGHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NEV8</accession>
    <name>A0A0F7NEV8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_31445</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019212.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_31445"/>
    <dbReference type="EnsemblBacteria" id="AKH85984">
        <property type="protein sequence ID" value="AKH85984"/>
        <property type="gene ID" value="AA958_31445"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_31445"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6644"/>
    <dbReference type="OrthoDB" id="1840317at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH85984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="193" mass="19736" checksum="D09C06236213D89C" modified="2015-07-22" version="1">MSGAYVLGADPGLTELRHADHLLHALAGELRLPRTAYGCTHLVAGERPRIAVSLALAGATDAAAAWRWLTARGHAVAGLPGGTRHGPGEAAAAAARAAAEHASRSVGRAVLYPGADALTGTMTVGELLGASAIEQVVLLGAPHGPPWEARMVTRGHVRPQWLDGRLVLAVIPAAAETLIPFEAPAPTPCCTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NF80</accession>
    <name>A0A0F7NF80_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LuxR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_20715</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020276.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_20715"/>
    <dbReference type="EnsemblBacteria" id="AKH86931">
        <property type="protein sequence ID" value="AKH86931"/>
        <property type="gene ID" value="AA958_20715"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_20715"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4369"/>
    <dbReference type="OrthoDB" id="930905at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="2"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="149"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH86931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="219" mass="23333" checksum="6B66AE2C66CAB2E7" modified="2015-07-22" version="1">MRVVIAEDSVLLREGLTRLLTDRGHEVVAGVGDGVALVKTVGDLAAEGSAPDVVVADVRMPPTHTDEGVRAAVQLRREHPDVGVLVLSQYVEEQYATELIAGSSRGVGYLLKDRVAEVREFVDAVVRVAEGGTALDPEVVAQLLGRSRKQDVLAGLTPREREVLGLMAEGRTNSAIAGQLVVSDGAVEKHVSNIFMKLGLAPSEGDHRRVLAVLTYLNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFB1</accession>
    <name>A0A0F7NFB1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Acetolactate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_31720</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019256.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_31720"/>
    <dbReference type="EnsemblBacteria" id="AKH86028">
        <property type="protein sequence ID" value="AKH86028"/>
        <property type="gene ID" value="AA958_31720"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_31720"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6698"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="PTHR18968"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="6">
        <location>
            <begin position="9"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_M" evidence="4">
        <location>
            <begin position="196"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="5">
        <location>
            <begin position="386"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH86028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="553" mass="59247" checksum="EFB4CF3003800026" modified="2015-07-22" version="1">MSTADTPEDVAHLLVRCLEAEGVTHVFGVPGEENIRFVDAVNASPSIDYVLVRHEQGASFMAEMYGRITGRAGVCSATLGPGAINLLLGVADAHTNSTPVVALAAQGGLDRVHKESHQVIDLPAMFAPVTDWSQQVRAPGAVPEMVRQAFKTAQSERPGAVFLALPEDIEGLVPDPPLNPLPINRPRPEAPSPAQLERAAEVLAGAARPILLAGHGATRAGARDALIRFSERLDIPVATTFNGKGVFPDDHPNALGAVGFMRHDYTNFGFDNADVLICVGYEPQEFDPVKINPQGDKQILHLHQFPAEVDSHYPVAVGVLGDPSSSLDGLAEAVGRTFHGDGRLIRGLLAEELAHGRRNSSFPLAPQRVVADVREALGREDVVLVDTGAGKMWMARLYPTYEPHTCLISNGLSTMGFAVPGAIGAKLARPDAQVLAMTGDGAFLMNSQELETAVREGIPMTVLVLVDDEYGLITWKMELEMGRHSHTRFANPDLVTYAESFGARGHAVKSADELLPTLRDALAHDGVDVISCPVDYTENLRLTDRLGALQGPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFH8</accession>
    <name>A0A0F7NFH8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Stage II sporulation protein E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_32875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019446.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_32875"/>
    <dbReference type="EnsemblBacteria" id="AKH86219">
        <property type="protein sequence ID" value="AKH86219"/>
        <property type="gene ID" value="AA958_32875"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_32875"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6945"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="1">
        <location>
            <begin position="168"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="400" mass="43894" checksum="B5CB67011F0FAC73" modified="2015-07-22" version="1">MQRALLRAGHLATFEQMPLLVAQHARTAGLHRARIFVADLQGEVLREVTGRGSDAGRGGQEFRILTTVPGTAYTETRLITVRTEEHGRFRQWIPLLNGAERLGVLSVDTDHSNDADLEAVQDLTSLVSLLLASKRTNSDAYARLIRTTSMTVSAEMQWPLMPPRSFSNDRVTLAAAMEPAYTTAGDAFDYGIAGETTYLAILDAMGHDTAAGLTANLAMATFRNQRRQGVSLPDTCAAIEDVLIAHYTHTRYATGILAELDMVTGVLTWVNCGHHSPVLVRGGRWTSELSCPPSHPLGTDLGLPVHACEVQLEPGDRVLLYTDGITEARDADGREFGRERFVDFVIRHQSDALPVPETLRRLIHAVLDYHDGKLDDDATVLLCQWHGNIDRLPAATYPPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFJ7</accession>
    <name>A0A0F7NFJ7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutathione peroxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_32995</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the glutathione peroxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019466.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_32995"/>
    <dbReference type="EnsemblBacteria" id="AKH86239">
        <property type="protein sequence ID" value="AKH86239"/>
        <property type="gene ID" value="AA958_32995"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_32995"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6971"/>
    <dbReference type="OrthoDB" id="1635499at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00340">
        <property type="entry name" value="GSH_Peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000889">
        <property type="entry name" value="Glutathione_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592">
        <property type="entry name" value="PTHR11592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00255">
        <property type="entry name" value="GSHPx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000303">
        <property type="entry name" value="Glutathion_perox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01011">
        <property type="entry name" value="GLUTPROXDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51355">
        <property type="entry name" value="GLUTATHIONE_PEROXID_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 5 6" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="4">
        <location>
            <position position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000303-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH86239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="162" mass="17476" checksum="0AE80595304D7D6F" modified="2015-07-22" version="1">MSVYDVELRTLAGEPASLGRFRGTAVLAVNVASKCGLTPQYAGLEKLHTQYAARGFAVAGFPCNQFGGQEPGTAEEIATFCSATYGVTFPVFEKIEVNGPDRHPLYRELVQTPDADGTAGDVQWNFEKFLLDPEGRPVARFRPQTTPDDAALIAAVEAVLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFM9</accession>
    <name>A0A0F7NFM9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Probable allantoicase</fullName>
            <ecNumber evidence="3">3.5.3.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Allantoate amidinohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">alc</name>
        <name evidence="5" type="ORF">AA958_28460</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>allantoate + H2O = (S)-ureidoglycolate + urea</text>
            <dbReference type="Rhea" id="RHEA:11016"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:17536"/>
            <dbReference type="ChEBI" id="CHEBI:57296"/>
            <dbReference type="EC" id="3.5.3.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Nitrogen metabolism; (S)-allantoin degradation; (S)-ureidoglycolate from allantoate (aminidohydrolase route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the allantoicase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.3.4" evidence="3"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018756.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_28460"/>
    <dbReference type="EnsemblBacteria" id="AKH85522">
        <property type="protein sequence ID" value="AKH85522"/>
        <property type="gene ID" value="AA958_28460"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_28460"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5997"/>
    <dbReference type="OrthoDB" id="651058at2"/>
    <dbReference type="UniPathway" id="UPA00395">
        <property type="reaction ID" value="UER00654"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004037">
        <property type="term" value="F:allantoicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000256">
        <property type="term" value="P:allantoin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00813">
        <property type="entry name" value="Allantoicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005164">
        <property type="entry name" value="Allantoicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015908">
        <property type="entry name" value="Allantoicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12045">
        <property type="entry name" value="PTHR12045"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03561">
        <property type="entry name" value="Allantoicase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016516">
        <property type="entry name" value="Allantoicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02961">
        <property type="entry name" value="allantoicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Allantoicase" evidence="4">
        <location>
            <begin position="43"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="Allantoicase" evidence="4">
        <location>
            <begin position="225"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH85522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="366" mass="39108" checksum="91837B276E89CDB0" modified="2015-07-22" version="1">MTAQMTRFTGAAAPYGGGDPYADYRTADFAFAALPDLADRRLGGAVIAANDEFFAPRENLLRPERAEFDPAAFGHKGKVMDGWETRRRRGASAGAPHPAAGDHDWALVRLGAPGVVHGIVVDTAHFRGNHPHSVSVEGAEVPGAPSPEALLADGVRWTELVPRTEVGGHAANGFAVAGGRRFTHLRLRQHPDGGIARLRVHGEVVPDPAWLAALGTFDLVALEHGGRVEDASDRFYSPPVNTIRPGRSRQMDDGWETRRRRDTGHDWIRYALAGRGEIRAVEIDTAYLKGNAAGWAAVSVRDGSAGGWTEILPRTRLQPDTNHRFVLPAAAVATHARIDIHPDGGISRLRLHGSLAPEGGAGAGDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NG04</accession>
    <name>A0A0F7NG04_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">3-hydroxyisobutyrate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_33635</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019576.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_33635"/>
    <dbReference type="EnsemblBacteria" id="AKH86354">
        <property type="protein sequence ID" value="AKH86354"/>
        <property type="gene ID" value="AA958_33635"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_33635"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.7102"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016054">
        <property type="term" value="P:organic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015815">
        <property type="entry name" value="HIBADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="NADP-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000103">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_binding_2" evidence="2">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="NAD_binding_11" evidence="3">
        <location>
            <begin position="152"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000103-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH86354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="280" mass="28035" checksum="D42E9B98A142A37F" modified="2015-07-22" version="1">MGAGMARSLLRGGVEVTVWNRTPERARPLAADGARVAPSAAEAVRDADAVLIALYDADAVLTVLGDALEASPEDTVWVQTATVGPEGTRMAAELAAGAGRTLVEAMLLGTRQPAETGRLTLLTAGDPAVFARIEPLTAAISVKTVWTGPEVGAGTALKLACNAWIASITAAAAQSLALAGALGLDPKLFLTAIEGAPADCGYAHAKGEGMLAGSYEPQFALDAALKDVDLIDGAARGAGVDTTLLAALRGLYGQASAAGHGREDLAAVYTSFGGPGGTGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-12-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NG65</accession>
    <name>A0A0F7NG65_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_29855</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018960.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH85732">
        <property type="protein sequence ID" value="AKH85732"/>
        <property type="gene ID" value="AA958_29855"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_29855"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6305"/>
    <dbReference type="OrthoDB" id="1875458at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH85732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="237" mass="25200" checksum="96EF56313EE69085" modified="2015-07-22" version="1">MSLTDKAIRRIRELITSGELPPGAKLPPEQQLAAELGLSRGLMREAVKALVVARVLEIRRGDGTYVTTLEPRVLLEGLGSAVELLQGDTLLELTEVRRLLEPVATGLAATRISAGELAGVAGHLAAMHAARDDVELLNKHDAAFHQAVASATGNQTLASLLEGISGRTVRARVWRGMVDGDVADRTLAQHQEIYDALAAGDAALAEAAALLHVSTTEAWLRRHLTPVKDAPRQETGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NGL8</accession>
    <name>A0A0F7NGL8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Anthranilate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_06685</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_06685"/>
    <dbReference type="EnsemblBacteria" id="AKH86584">
        <property type="protein sequence ID" value="AKH86584"/>
        <property type="gene ID" value="AA958_06685"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_06685"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1395"/>
    <dbReference type="OrthoDB" id="1786019at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071704">
        <property type="term" value="P:organic substance metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd01743">
        <property type="entry name" value="GATase1_Anthranilate_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019999">
        <property type="entry name" value="Anth_synth_I-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006221">
        <property type="entry name" value="TrpG/PapA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236">
        <property type="entry name" value="PTHR11236"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="SSF56322"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chorismate_bind" evidence="2">
        <location>
            <begin position="111"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="GATase" evidence="1">
        <location>
            <begin position="437"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH86584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="629" mass="66220" checksum="0DC72E2EBAA62A7A" modified="2015-07-22" version="1">MLADGAPPFAVLRRRTPGRPDAPVEVLLGAVHEVDRLADIPGSPAPGAVGALALVPYRQIRERGFDVRDDGTPLAVLVPDEVHELPAASLLDALPAHGVRVEGGGFDVPDEEYAGIVGRVLADEIGTGEGANFVIRRTYEGRVDGFGAADALALFRRLLAGEQGAYWTFVVHRPGVRTLVGASPEVHVRMTGGTVVMNPISGTYRYPPGGPDRSGLLAFLHDAKEIEELSMVVDEELKMMCTVAREGGVVVGPRLREMAHLAHTEYELRGRTALDARDVLRETMFAATVTGSPVQNACRVIERYEAGGRGYYAGALALLGRDAGGAQTLDSPILIRTADIGADGLLRVPVGATLVRGSRPADEVAETHAKAAGVLAALGVRPARPGPAGGSGPRFAADPEVQAALAARRTHLSPFWLRMQRVQDPAAAGPVPGRVLVVDGEDTFTAMLAHVLRASGAEVDVRRFDAPGVRDAALAHEGPVVLGPGPGDPADTADPKMRFLRGLAGDLLAGHRHGLLGVCLGHELLAAELGLPLVRKDVPYQGAQEEIDFFGRPETAGFYSTYTARCDDAAAAALAAARGVELSRDPRTGDVHALRGPGFAGVQFHPESVLTLDGDRLVRQLLAAVLVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NGP9</accession>
    <name>A0A0F7NGP9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_30965</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019130.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_30965"/>
    <dbReference type="EnsemblBacteria" id="AKH85902">
        <property type="protein sequence ID" value="AKH85902"/>
        <property type="gene ID" value="AA958_30965"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_30965"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6543"/>
    <dbReference type="OrthoDB" id="1687028at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="8"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="152"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH85902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="221" mass="24379" checksum="B54B3F1C1E358581" modified="2015-07-22" version="1">MNRAVKARVLLADDHALVRRGIRLILDAEPDLTVAAEAGDGAEAVALARDPAVAVDLAILDVAMPRLTGLQAARELCRVRPGLRILILTMHDNEQYFFESLKAGAAGYVPKSVADRDLVEACRAALRDEPFIYPGAETALVRRYLDRARQGDPLPARPITEREEEILKLVAEGHTSKEIGDLLVISARTVERHRANLLQKLGLRDRLELTRYAIRAGLIEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NHU0</accession>
    <name>A0A0F7NHU0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA polymerase-binding protein RbpA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rbpA</name>
        <name evidence="2" type="ORF">AA958_33455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds to RNA polymerase (RNAP), stimulating transcription from principal, but not alternative sigma factor promoters.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Bind 1 Zn(2+) per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a complex with the RNAP catalytic core and with free principal sigma factors.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNA polymerase-binding protein RbpA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_026276152.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_33455"/>
    <dbReference type="EnsemblBacteria" id="AKH86322">
        <property type="protein sequence ID" value="AKH86322"/>
        <property type="gene ID" value="AA958_33455"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_33455"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.7065"/>
    <dbReference type="OrthoDB" id="1912152at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001000">
        <property type="term" value="F:bacterial-type RNA polymerase core enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01483">
        <property type="entry name" value="RbpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038638">
        <property type="entry name" value="RbpA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025182">
        <property type="entry name" value="RNApol-bd_RbpA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13397">
        <property type="entry name" value="RbpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="124" mass="14080" checksum="4EC31DECB7D6FE26" modified="2015-07-22" version="1">MSERALRGTRLVVTSYETDRGIDLAPRQAVEYACQNGHRFEMPFSVEAEIPPEWECKTCGAQALLVDGEGPEEKKVKPARTHWDMLMERRTRDELEEVLAERLAVLRSGAMNIAVHPRDSRKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NHX9</accession>
    <name>A0A0F7NHX9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_18885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020213.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86883">
        <property type="protein sequence ID" value="AKH86883"/>
        <property type="gene ID" value="AA958_18885"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_18885"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3964"/>
    <dbReference type="OrthoDB" id="1441363at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="258" mass="27151" checksum="40A187C04FA9CB09" modified="2015-07-22" version="1">MHDHDTTGRLASFADVLADQLPGTWTTTHLPTDDRDHRSYLADLAELAERIWDLDLAAASLAEQPLQRAAVLSRPDGAQLALLDRHDGGDGFLIAPVAPRALPDEAYRGVREPNGIALAGDPFLDAEAVASDLLVRYDAALAEVRHNALGGTQPSQPDRLVLTWQPDGSIATAPIGDTAGPVLTEAGFVQDPHTGIYSLAADDTRAQARAVRAIGPQLDALGITTALQHPTSRSAPSAAPSTSPPPEGARPSRTGRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NHZ4</accession>
    <name>A0A0F7NHZ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Lactate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_28380</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_28380"/>
    <dbReference type="EnsemblBacteria" id="AKH87084">
        <property type="protein sequence ID" value="AKH87084"/>
        <property type="gene ID" value="AA958_28380"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_28380"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5981"/>
    <dbReference type="OrthoDB" id="1638924at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2-Hacid_dh" evidence="4">
        <location>
            <begin position="17"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="2-Hacid_dh_C" evidence="5">
        <location>
            <begin position="91"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH87084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="301" mass="32653" checksum="3909EED0646AB241" modified="2015-07-22" version="1">MAPRLGVVPTLTAAAISEANAGLARGNRCISVDHKTRITGSTLRALSRVGVAYISTRSIGYNHIDVEYAESVGISVENVAYSPDSVADYTLMLMLMAVRHAKSTLRRADVHDYRLQDVRGRELRDLTIGVVGTGRIGAAVIDRLRGFGCRILAHDARSGTDADYVPLDELLRLSDMVTLHTPLTPETYHLLDGRRIKLMKHGAVIVNTGRGALLETGALLAALEDGRLGGAALDVLEGEEGIFYADRRDEPLTSGPLPRLQELPNVLISPHTAYYTDHALSDTVENSLTNCLAFESRNQRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NI73</accession>
    <name>A0A0F7NI73_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_22490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020328.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_22490"/>
    <dbReference type="EnsemblBacteria" id="AKH86968">
        <property type="protein sequence ID" value="AKH86968"/>
        <property type="gene ID" value="AA958_22490"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_22490"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4733"/>
    <dbReference type="OrthoDB" id="877941at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="326" mass="33771" checksum="5F75FB145172FFC4" modified="2015-07-22" version="1">MLPAPGRHGPLGRQGPPGLPGPTVTALRHPREQPLEEALAEVSAVLEQHGFLVVLHPAATSAEVVRRLHTVRSVLESDRMALVPLPLPPLAVAVIARQLLQLSTADLGAGVLATAARLLTHYIHAGAVLGSVAKLDRVPVTLGAHARSWVPGAQFAVLAAPHPQLVRIGRDPVPPGPDFATGLVHASGRADAAWVTGELAAGWRVQGMEMAPLPAASAPWWATDKVCEFAAGITDPLVLSRLVASVQRARCSWCGLEIIGDRCLLCATPVPPGPAAPSPPLPQAVPAPVPHQGAPPPVAQPPPQSVPPYHQPAVGAAPPSPPEINR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NIB3</accession>
    <name>A0A0F7NIB3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Trypco2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_24165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020370.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH87003">
        <property type="protein sequence ID" value="AKH87003"/>
        <property type="gene ID" value="AA958_24165"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_24165"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5092"/>
    <dbReference type="OrthoDB" id="2098977at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045608">
        <property type="entry name" value="Trypco2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19631">
        <property type="entry name" value="Trypco2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trypco2" evidence="1">
        <location>
            <begin position="6"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH87003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="83" mass="8838" checksum="35C78CCB251330DA" modified="2015-07-22" version="1">MNTARTEGGPVRLSVSSLELELQTTLSRSGGVNGGIKVHVISAGAERTEGRSDVQTLRLQLDAKTALDDRPVPAGDTVDRRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-12-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NIG0</accession>
    <name>A0A0F7NIG0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PadR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_00040</name>
        <name evidence="3" type="ORF">AA958_34220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_037730261.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86449">
        <property type="protein sequence ID" value="AKH86449"/>
        <property type="gene ID" value="AA958_00040"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH87229">
        <property type="protein sequence ID" value="AKH87229"/>
        <property type="gene ID" value="AA958_34220"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_00040"/>
    <dbReference type="KEGG" id="strc:AA958_34220"/>
    <dbReference type="OrthoDB" id="1706427at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="1">
        <location>
            <begin position="21"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH87229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="107" mass="11636" checksum="15844639736E3674" modified="2015-07-22" version="1">MTLQTQLVLRALLESPADARYGLELSQEAGLPTGTIHPILARLENAGWLESFWEDRGEIEKTDPPRPRRRFYRFTSGGAEAARLALAAAYQGGAASARLRPAEGLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NIQ9</accession>
    <name>A0A0F7NIQ9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cobW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_10990</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_10990"/>
    <dbReference type="EnsemblBacteria" id="AKH86682">
        <property type="protein sequence ID" value="AKH86682"/>
        <property type="gene ID" value="AA958_10990"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_10990"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2314"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="cobW" evidence="2">
        <location>
            <begin position="12"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH86682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="414" mass="41973" checksum="96482D81F4070A93" modified="2015-07-22" version="1">MGGPVTAPVSFAVVGGFLGAGKTTTLAALTRELRARGRRVALVANDQGDDLVDTRLAEAAAGWAGEVTGGCFCCRFEDLLDVVTRAVEEYGADTVLAEAVGSCTDLQATVVRPLRQRYGTRFRVAPLLTVVDPARFAALGRAGEADLAYLFDRQLADADVIALNKADAVDPALSAAVRTALASLHPGRPLLTYSARTGTGLPALAETLTGPADAVRHPAPADPTAPAGPAVHADSAAPATPRVTAAPGASAGRDRDRDLVIDYDRYAAAEARLAWLNHTAEVRAPHSAAGFPSARWAATLLAELTAGAALVGHVKVHLTAPDGRTTKASAVGDGRAPAVDADGGAMRSAQAVVNARLACPAAELDAALAAAVRAADAAAGAATTAAAPPAAFHPACPRPVHRLPATAPPPVTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NIV5</accession>
    <name>A0A0F7NIV5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_32825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020641.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH87203">
        <property type="protein sequence ID" value="AKH87203"/>
        <property type="gene ID" value="AA958_32825"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_32825"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6935"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH87203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="125" mass="14274" checksum="26DD312E7574299E" modified="2015-07-22" version="1">MSWFPVLGTVGYVAGIPLAARLFYGLLRRQIIFLDGRERTDPVGYFDTHDRPGVTAAAVAAGLLWPLRVPVYAAGRIVVTVVTARPRRSRYERRLDARHVHERIRQLEDELGIPDEAPERDRTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NJE7</accession>
    <name>A0A0F7NJE7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA mismatch repair protein MutT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_19520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020252.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_19520"/>
    <dbReference type="EnsemblBacteria" id="AKH86907">
        <property type="protein sequence ID" value="AKH86907"/>
        <property type="gene ID" value="AA958_19520"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_19520"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4113"/>
    <dbReference type="OrthoDB" id="1308416at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="15"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="155" mass="17007" checksum="CB8135D9A0C5F69C" modified="2015-07-22" version="1">MTRTEYYDDPAAPEPNSLVAASAVVTDDAGRILLQRRRDNGLWALPGGGMDLGDSLPGCAVREVKEETGLDVEVTGLVGTYTDPRHIVAYSDGEVRRQFNVCFTARVVGGTLAISEESTELRFVDPGELGALPMHHTQRLRLRHFLDHRSTPYLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NK88</accession>
    <name>A0A0F7NK88_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_34085</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH87222">
        <property type="protein sequence ID" value="AKH87222"/>
        <property type="gene ID" value="AA958_34085"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_34085"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.7203"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH87222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="69" mass="7574" checksum="59037B8853C492E1" modified="2015-07-22" version="1">MCSSRQAEITDALVALLVALVHKINARAERRMKKHLTAELKKVRGKGGILWRVPQLARLGEQATGTVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-12-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MXL7</accession>
    <name>A0A0F7MXL7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_01060</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CdaR family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH80990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014356.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH80990">
        <property type="protein sequence ID" value="AKH80990"/>
        <property type="gene ID" value="AA958_01060"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_01060"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.233"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041522">
        <property type="entry name" value="CdaR_GGDEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012914">
        <property type="entry name" value="PucR_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17853">
        <property type="entry name" value="GGDEF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07905">
        <property type="entry name" value="PucR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PucR" evidence="2">
        <location>
            <begin position="8"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF_2" evidence="4">
        <location>
            <begin position="285"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_30" evidence="3">
        <location>
            <begin position="462"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH80990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="524" mass="54790" checksum="E06F8F5B6D7C0074" modified="2015-07-22" version="1">MLTISALAALPRLGLAVLVPGPPGVLDAEIAWLHNTELPDPSGYVGRTELVLTNGLWLPTTPPDEFVDHCLAAGAAGIVFGLRDATPHTPAALTDACRAAGLPLLQLPIDVPFTAVTQAASDIRATEQQTPLAVTLRRGTAFTDALSAGAGAEGVLRVLRREFDLPLAVVDRTGAVLAHSADAAPGADDAHIAATALTRTPPPMELAIADGATATLLPVGALGHPEAALLCLRPAAGLTEPQQQALSQAAHYLAMEIARRQAVRASEERFASELVDMVVSGVESPVTLTRRLVAFGIDPAQPLAALAVTSRAGVPVTDLAAATRTTLQDQGIPAVVAAGHADVVAVCTWRRPAEALPAWCRQVTGADLARERRPPLLPDGSVVGVGGPVTSPGHLRTAVLEARRASAVLAQTSRHLTVARLTDLPTYHTLLSRADPQTLHQLTAVLGALRDYDAAHEGRLENTLRTFLEHQASPSAAARVMHLHINSLYKRLARITELTGRDTATLTGRLDLLLALEADALTAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MY04</accession>
    <name>A0A0F7MY04_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_01880</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014489.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH81125">
        <property type="protein sequence ID" value="AKH81125"/>
        <property type="gene ID" value="AA958_01880"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_01880"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.408"/>
    <dbReference type="OrthoDB" id="1809199at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="300"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="355"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="382"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="10"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="192"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH81125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="415" mass="41033" checksum="4726FD0AABCFDF13" modified="2015-07-22" version="1">MPRGPAGAQLARLRTVLTVFFALDGFVFAGWVVRIPDIKDQTGASPSALGLALLGVSAGGVATMVLTGGLIRRYGAHAVTVGTAALLSAGVVLPPLTRSALALGLVLVVFGAAFGSISVAMNSAAVDLVAALRRPVMPSFHAAFSLGGMLGAGLGALVAGHLSPTRHLLLLALLGLAVTAFAGPALLALPAPKRPPAPEDADRADVPDTSGSDAAAGRGPAAAERPAGRTRLLVAVLGLVALCTAYGEGAMADWSALHLKESLDAGPGMAAAGYSVFALAMTAGRLSGTALLLRLGQNRALVTGGATACVGMLLGSFSPYVWGALAGFALTGLGLANIFPIAIGRAGELAGPNGVAAASTLGYGGMLLGPPAIGFLADWFSLRAALSTVALLAGAAALIAYAMQAVQNGGRPRGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MZ34</accession>
    <name>A0A0F7MZ34_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_04340</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014900.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_04340"/>
    <dbReference type="EnsemblBacteria" id="AKH81545">
        <property type="protein sequence ID" value="AKH81545"/>
        <property type="gene ID" value="AA958_04340"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_04340"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.912"/>
    <dbReference type="OrthoDB" id="1584669at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="188"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="234"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="68"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH81545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="274" mass="30283" checksum="52D1B37792F858CA" modified="2015-07-22" version="1">MIVGRREVWTGRLFLVLLMTVTVVPFISLFVTALHPAGSYPQGLQWPSDPQWGNFAEAFRLSNMGELLKSSALIVVGVVPVAVVLATMAGFAIGHLRMVGARAVFLLFVFGLTLPYEGIITPLYYLVRDMGMLNTRWAIILPLIGLFMPFAIFWMRAHFINVPDELSEAAEIDGANVWQLFWRIHVPLAMPAISSLAILLFLWTWNQFLLAIVLVDDPTSRTMAGALGAFQGQWGTNIPLLCAGSLLILAPTLIIFLIFQRRFVAALLQGSVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MZQ7</accession>
    <name>A0A0F7MZQ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_02250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014550.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_02250"/>
    <dbReference type="EnsemblBacteria" id="AKH81186">
        <property type="protein sequence ID" value="AKH81186"/>
        <property type="gene ID" value="AA958_02250"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_02250"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.483"/>
    <dbReference type="OrthoDB" id="1439085at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033922">
        <property type="term" value="F:peptidoglycan beta-N-acetylmuramidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008302">
        <property type="entry name" value="NamZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42915">
        <property type="entry name" value="PTHR42915"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07075">
        <property type="entry name" value="DUF1343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016719">
        <property type="entry name" value="UCP016719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002518973" evidence="1">
        <location>
            <begin position="29"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="429" mass="46587" checksum="243CCA53EF079CA9" modified="2015-07-22" version="1">MPRPSAPSRRTLLTGTAAGAAVPLLAGAAPARAGGRPAALQAGADAAAAEGWSVLRGRRLGIVSNPTGILRDTRHVVDSMHTSGTLDIAGVFGPEHGFRGSAQAGEAEPETIDPRTGLTVYDAYGANAAKMAELFAKAGADTIVFDIQDVGARFYTYIWTMYNAMVAARETGAAFVVLDRPNPIGRRADGAMMTPGFTSGVGLKPIVQQHGMTVGELARYFNGELLPDEGAGGRVELEVVRVRGWDPESYAQDGDLPWVPPSPNMPTADTALAYAGTCFFEGTNLSEGRGTTRPFEWIGAPYLDYHYSDRLNARGLPGVEFREAYFVPTFGKHVGATCAGVQVHVADRRRYEPVTAAVAMLVEAARYPEFAWRQDSWDPQRPFWIDKLSGSPRMRTMIDEGRDVAEVVAAWKDELADFTRRRRRYLLYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N013</accession>
    <name>A0A0F7N013_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP-dependent protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_06405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015253.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_06405"/>
    <dbReference type="EnsemblBacteria" id="AKH81900">
        <property type="protein sequence ID" value="AKH81900"/>
        <property type="gene ID" value="AA958_06405"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_06405"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1337"/>
    <dbReference type="OrthoDB" id="1474822at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003111">
        <property type="entry name" value="Lon_prtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046336">
        <property type="entry name" value="Lon_prtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02190">
        <property type="entry name" value="LON_substr_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00464">
        <property type="entry name" value="LON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51787">
        <property type="entry name" value="LON_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lon N-terminal" evidence="1">
        <location>
            <begin position="6"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="245" mass="26282" checksum="24CD330B77893440" modified="2015-07-22" version="1">MTTARLPLFPLNAVLFPGLVMPLNVFEERYRAMMRDLRKLPEAERRFGVVAIRDGREVAPTGPGLPDQTALPRRGPAAGFGADPMQAFYGVGCVADAATIREKDSGGYEVLVTGTRRFRLLSVDAAGEYLTGEVEALPEQSGEGAGVLSAAVVRAFRTYQKRLAGARERSLGAATELPDEPSVLSYLVAAAAVLDTPSKQQLLQARDTASRLSAELKILRRESAVLGKLPSLPAVDLTRHPTSPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0D3</accession>
    <name>A0A0F7N0D3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_00260</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH80858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014224.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_00260"/>
    <dbReference type="EnsemblBacteria" id="AKH80858">
        <property type="protein sequence ID" value="AKH80858"/>
        <property type="gene ID" value="AA958_00260"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_00260"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.62"/>
    <dbReference type="OrthoDB" id="1753304at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038721">
        <property type="entry name" value="IS701-like_DDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13546">
        <property type="entry name" value="DDE_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_5" evidence="2">
        <location>
            <begin position="22"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="414"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="464"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH80858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="481" mass="53968" checksum="19B24931A0E9E954" modified="2015-07-22" version="1">MSLPVHAPAGEALDVLSRFRVEFYEALHSRQDALFELTDAVLCADGPVKTLVELSLAVEHRRGHGALYAALDRGWLEPERLRRTLAGLPVPKAADGRIVLAVDVSNWLRPDAPTSDDRLFCHVYGRGDRKTDQFVPGWPYSFVAALEPGRTSWVAMLDAMRLGPADDATLVTAAQLRGVIERVTAAGHWHPGDPEILIVMDAGYDVAYLTHALADLPVVCLGRLRSHRVMLRDPGPARSGPRGGRPRRHGGVLSFAKPDSWHTPEVTTVTDTTRYGTAAAMAWDRMHPRLTHRGPWLEHAKEELPVLHGTLIRLKVERLPGDREPKPVWLWCSATSALPADVDRWWQSFLRRFDLEHTFRLMKQTLGWTAPKVRHADTADLWTWLIIAAHTQLRLARTLAEDLRRPWERPAEPRRLTPARVRRGFRNIRTTTARPAAAPKPSRPGPGRPPGSKNKHRAKRHDVGKTVKRAESIKEHQAQQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0G8</accession>
    <name>A0A0F7N0G8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chitinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_07675</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 18 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015480.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_07675"/>
    <dbReference type="EnsemblBacteria" id="AKH82130">
        <property type="protein sequence ID" value="AKH82130"/>
        <property type="gene ID" value="AA958_07675"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_07675"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1613"/>
    <dbReference type="OrthoDB" id="1081028at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002518938" evidence="5">
        <location>
            <begin position="41"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="6">
        <location>
            <begin position="55"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH82130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="343" mass="35666" checksum="4F0DC046ADB1344A" modified="2015-07-22" version="1">MARARTHKFRKTRKRLVGSLAAASLTAGALAAAVVTEAAADPEPVTHGAAAVPAHAVTGYWQNFDNGATVQTLADVPEAYDIIAVAFADATGTPGQVDFTVDPALDYTEDAFKADVAAKQESGKSVVISVGGERGAVSVNDAASAEAFATSILGLMEEYGFDGVDIDLENGLNSTYMTQALEAIHAGAGDGLVVTMAPQTIDMQSPENEYFKTALNIKDFLTVVNMQYYNSGSMLGCDGKVYSQGTVDFLTALACVQLENGLDPSQVGLGTPASSRAAGGGYVEPGVVTDALDCLTRGTGCGSFTPERTYPELRGAMTWSTNWDAADGNAWSDTVGPHVDQLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0N9</accession>
    <name>A0A0F7N0N9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_00995</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH80978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014344.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_00995"/>
    <dbReference type="EnsemblBacteria" id="AKH80978">
        <property type="protein sequence ID" value="AKH80978"/>
        <property type="gene ID" value="AA958_00995"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_00995"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.220"/>
    <dbReference type="OrthoDB" id="1687028at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="2">
        <location>
            <begin position="218"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH80978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="412" mass="43629" checksum="9B5193883D38FDE0" modified="2015-07-22" version="1">MVGVPPSPRHLLRPLRPVLRAVTYTRWLHLFIAATLALLGAFVWGVEDVHPVVSYAVLALGPVPLLAVAAAIPGTRLLETMQARLLLFPGPHGTEAQPDPGLARTPAVSWADRGRVFVWLALRMWVGLLAAVVGIQGIFLTVALTSAHHWRSFEEEVLALPGEWHGSYPLLVPVAVAVLLATGCALGVLIAALAPRLLGPSAAERLAALEERTERLLEHNRLARELHDTIGHALTVAVVQAGAARAAGSPEFTERALAAIEDTGREALEDLERVLRLLRQEGAPPSRRPGLAEAERLVASARGAGADISAEIEGPLESVPGPVSREGYRIVQECLTNVLRHAGPVPVRVRIAASAGGLELHVRNRLPAAAAPPGPGGSGLRGIRERAALLGGEAVAGPSDGEWRVRVTLPIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0S6</accession>
    <name>A0A0F7N0S6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">ATP-dependent Clp protease proteolytic subunit</fullName>
            <ecNumber evidence="5 8">3.4.21.92</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Endopeptidase Clp</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">clpP</name>
        <name evidence="11" type="ORF">AA958_00885</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 9">Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 10">Belongs to the peptidase S14 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.92" evidence="5 8"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH80959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014325.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_00885"/>
    <dbReference type="EnsemblBacteria" id="AKH80959">
        <property type="protein sequence ID" value="AKH80959"/>
        <property type="gene ID" value="AA958_00885"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_00885"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.197"/>
    <dbReference type="OrthoDB" id="1728970at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07017">
        <property type="entry name" value="S14_ClpP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00444">
        <property type="entry name" value="ClpP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001907">
        <property type="entry name" value="ClpP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023562">
        <property type="entry name" value="ClpP/TepA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033135">
        <property type="entry name" value="ClpP_His_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018215">
        <property type="entry name" value="ClpP_Ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381">
        <property type="entry name" value="PTHR10381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00574">
        <property type="entry name" value="CLP_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00127">
        <property type="entry name" value="CLPPROTEASEP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00382">
        <property type="entry name" value="CLP_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00381">
        <property type="entry name" value="CLP_PROTEASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 8" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 8" id="KW-0720">Serine protease</keyword>
    <feature type="active site" evidence="6">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 7">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AKH80959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="211" mass="23225" checksum="09092B2729469FBA" modified="2015-07-22" version="1">MDSPTARYVLPEFTERTSSGVRTQDPYSKLLEERIVFLGTQVDDTSANDVMAQLMHLEHAAPDQDISLYINSPGGSFTAMTAIYDTMQFVTSDIETVCLGQAASAAAVLLAAGTPGKRYVLPGARVLIHQPSFAEPVEGQASDLEIHARELLRHRALLEELLARHSGTPIEQIREDIERDKILDAEQAIAYGLADRMTESRKGTRTAHYGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0S7</accession>
    <name>A0A0F7N0S7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_08280</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015580.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_08280"/>
    <dbReference type="EnsemblBacteria" id="AKH82230">
        <property type="protein sequence ID" value="AKH82230"/>
        <property type="gene ID" value="AA958_08280"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_08280"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1747"/>
    <dbReference type="OrthoDB" id="694191at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="5">
        <location>
            <begin position="89"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="4">
        <location>
            <begin position="248"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH82230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="432" mass="45813" checksum="D3DB60475CDE8A8F" modified="2015-07-22" version="1">MPQHVPPSLDADALRRTHPHPAGSAGVPASRGAEGHDAQRRGSRGPEDGGARAAGTRAADGRGGDGDGGAHAARRITFLARRDLGNPAAGGSELLVDRLAGGLTDHGHQVTLVCGGPAAYRDYRVVSAGGDAGHFLRARRALSRHVGGTDLLVEVCNGMPYLAPLWHSGPSLCLVNHVHTELWAMRYPGPLARLGRRLEHWALAGAHRGNLLVAVSSSTATALRNIGVDPKRIRVVHNGVEDPGPLPQKSPEPLFLAMGRLVEYKRIDLLLRLWERVRPVTGGRLVIVGTGPERGRLEAMAGPGVTFTGHVSEGEKHRLLASSWLLLHPSLVEGWGLVVTEAAVRGTPAIGFDIPGLRDSIRDGDTGMLARGESAFAAHWCALALSEERRAALGAAARRRAARLSWEATVRDFRAVADEALARAGQHDKRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0Y0</accession>
    <name>A0A0F7N0Y0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 5">Thymidylate synthase</fullName>
            <shortName evidence="5">TS</shortName>
            <shortName evidence="5">TSase</shortName>
            <ecNumber evidence="1 5">2.1.1.45</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">thyA</name>
        <name evidence="8" type="ORF">AA958_08555</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP = 7,8-dihydrofolate + dTMP</text>
            <dbReference type="Rhea" id="RHEA:12104"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57451"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="2.1.1.45"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Pyrimidine metabolism; dTTP biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.45" evidence="1 5"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015623.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_08555"/>
    <dbReference type="EnsemblBacteria" id="AKH82275">
        <property type="protein sequence ID" value="AKH82275"/>
        <property type="gene ID" value="AA958_08555"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_08555"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1805"/>
    <dbReference type="OrthoDB" id="1212177at2"/>
    <dbReference type="UniPathway" id="UPA00575"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004799">
        <property type="term" value="F:thymidylate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006231">
        <property type="term" value="P:dTMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00351">
        <property type="entry name" value="TS_Pyrimidine_HMase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.572.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00008">
        <property type="entry name" value="Thymidy_synth_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045097">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023451">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036926">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000398">
        <property type="entry name" value="Thymidylate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020940">
        <property type="entry name" value="Thymidylate_synthase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11548">
        <property type="entry name" value="PTHR11548"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00303">
        <property type="entry name" value="Thymidylat_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00108">
        <property type="entry name" value="THYMDSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55831">
        <property type="entry name" value="SSF55831"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03284">
        <property type="entry name" value="thym_sym"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00091">
        <property type="entry name" value="THYMIDYLATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4 5" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thymidylat_synt" evidence="7">
        <location>
            <begin position="5"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="128"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="168"/>
            <end position="171"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="209"/>
            <end position="211"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH82275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="265" mass="30041" checksum="5F73B262B57A6466" modified="2015-07-22" version="1">MADTQYEDLLRTVLTSGTAKADRTGTGTRSVFGHQLRYDLAQGFPLITTKRVHLKSIVYELLWFLRGDSNVGWLQEHGVSIWDEWAGPDGELGPVYGVQWRSWPTPDGRHVDQISDVLDTLRRNPDSRRMIVSAWNVAELENMALPPCHAFFQFYVAEGRLSCQLYQRSADLFLGVPFNIASYALLTHMVAQQTGLEPGDFIWTGGDCHIYDNHVDQVTEQLARTPYEFPGLRLRRAESLFDYAYADVEVVGYRHHPAIKAPVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N131</accession>
    <name>A0A0F7N131_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_05295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015065.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_05295"/>
    <dbReference type="EnsemblBacteria" id="AKH81711">
        <property type="protein sequence ID" value="AKH81711"/>
        <property type="gene ID" value="AA958_05295"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_05295"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1111"/>
    <dbReference type="OrthoDB" id="1456605at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
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            <end position="359"/>
        </location>
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            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AKH81711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="363" mass="39188" checksum="9B8F2E4726129552" modified="2015-07-22" version="1">MSESPVLRVRGRVLTGREEVRDELWVVGGRVTFTPPAAAREVVDIEGWALPGLVDAHCHVGLDAHGAVDDATSEKQARTEREAGALLLRDAGSAADTRWIDGRDDLPRLVRAGRHIARTRRYIRNYAHEIEPDDLVAYVAREARRGDGWVKLVGDWIDREAGDLTPCWPREALAPAIAEAHRLGARVTAHCFAEDSLRDLVEAGIDCIEHATGLTEETVPLFAERGVAIVPTLVNIATFPELAAGGQAKFPRWANHMRRLHDRRYATVRAAYDAGIPVYAGTDAGGSLAHGLVGQEVGELVAAGIPAADAVSAAAWGAREWLGRPGLEEGAPADLVVYEADPLADVRVLTAPRRIVLRGRVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N153</accession>
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        <name type="scientific">Streptomyces sp. CNQ-509</name>
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        <lineage>
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
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    <dbReference type="OrthoDB" id="1771853at2"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR023365">
        <property type="entry name" value="Sortase_dom-sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042001">
        <property type="entry name" value="Sortase_F"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04203">
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF63817">
        <property type="entry name" value="SSF63817"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
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        <location>
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            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH81133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="263" mass="26749" checksum="239F61869EF5BBDE" modified="2015-07-22" version="1">MHEQRTIDPYAAMPYGMTPHGTLPHDTAGYGAAPNGTAPGGPPADPGGDGGGGGTVAGALRRRFAAGVVICVMLLGIGMIHTALTGGFGPPQPSAESALADDGPPAHPPLAASQPATIRIPAIGLDAPLTGVGLDSDGWLAAPPPGVPNLAGWYRDAATPGATGTAVVTGHVDDAAGPAVFYRLGGLKRGDVVKVDREDGRTAEFTVYAVEVFDAADFPSRRVYGDTDRAELRVLTCGGRYREGNDPGYEGNVVVFARLTDVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-10-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N1B2</accession>
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    </gene>
    <organism evidence="9 10">
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        <lineage>
            <taxon>Bacteria</taxon>
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    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP011492">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="AA958_05895"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_05895"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1234"/>
    <dbReference type="Proteomes" id="UP000034283">
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    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
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        <location>
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            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="268"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="406"/>
        </location>
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            <end position="561"/>
        </location>
    </feature>
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            <end position="586"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="622"/>
        </location>
    </feature>
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        </location>
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        </location>
    </feature>
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            <end position="343"/>
        </location>
    </feature>
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            <begin position="725"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH81811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="745" mass="77626" checksum="84EAE2C9008D4C67" modified="2015-07-22" version="1">MSAHRADPPPTAPATRPGLFARLADWSRRRRRLAILLWIVVLLGVTAASQGAGSNWRNDFSLPGTGSQAATDLLEKHGSAQAGDSVEIVFKDERGLRAAGTEQDVERLLEQVRGLPSVVDVRSPYADGGAAVSEGGDVAYATVTLDGKAETVPKADVEKIIDTAQDARTDALQIELGGEAVRGAEEEGGGGAEGAGMLAALVILVLLFGSLVAAAVPLVTALFAVGTAVGLITLAGHFFTVADFTPPIMMLVGLGVGVDYALLIFYRYRHELIRGADRDTAVRIALDAAGRTVFFAGCTVIVALLGLVALGLGSLQGVALSVALTVLVTMAASLVLLPALLAVLGRRIQRHVLKRAEKAAAKGKVEGSRWRALAGAVQRRPLPALVAALVALVALSAPVLGMRLGFADAGNDAPSSTSRKAYDLLAEGFGPGFNGPLVVVAQGDAGAGAAEAGEQAQARIAEADGVAATTPPLPSEDGEVSTVLVFPESAPQDEATADLVHDLRDDVLPPLAAETGAEYLVGGATAGTQDFSDTVADRMPLFVALVVGLSTLLLMVVFRSLWIPLKAAVLNLLSIGAALGVITLVFQEGWFGVEQGPIEAFIPVMIFAIVFGLSMDYEVFLVSRMHEEWERTKNAGLAVREGLAVTGQVITAAALIMIVVFAAFILSPSRMLQQFGLGLAVAILLDALVIRCLIVPAVMQLLGRHAWWLPGPLARKLPRVALERPEGPVGHEEGERSGQRGVGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N1K1</accession>
    <name>A0A0F7N1K1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_02655</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH81254">
        <property type="protein sequence ID" value="AKH81254"/>
        <property type="gene ID" value="AA958_02655"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_02655"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.567"/>
    <dbReference type="OrthoDB" id="1667781at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519159" evidence="2">
        <location>
            <begin position="25"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH81254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="256" mass="26857" checksum="552A589E8DD0D49D" modified="2015-07-22" version="1">MRRLATALAAVLAGAVALTPLAQAAAPAAAPDPAPGGPQRPYEPDVEGTDNIDTLDVTATRGPGRSVTVAFDRRSRAAEGTTPVAARRFVFLFDSSVSLRPESFPTCARAVVEAGGVAACPPGSLVGEGLGTWPDGSEHEVTVVNTRVDGTPGVLVVIPGAGSILEQTFERVADPYRGDYRWAADEILPPSPVPPGERVGTTRFQLSFGATREDRGRTVGFVETTARPGDELRFGLWSEFVTGQVVLPTATVRLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N1S3</accession>
    <name>A0A0F7N1S3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable transcriptional regulatory protein AA958_03305</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_03305</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the TACO1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014727.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_03305"/>
    <dbReference type="EnsemblBacteria" id="AKH81368">
        <property type="protein sequence ID" value="AKH81368"/>
        <property type="gene ID" value="AA958_03305"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_03305"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.703"/>
    <dbReference type="OrthoDB" id="1304328at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.980">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00693">
        <property type="entry name" value="Transcrip_reg_TACO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017856">
        <property type="entry name" value="Integrase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002876">
        <property type="entry name" value="Transcrip_reg_TACO1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026564">
        <property type="entry name" value="Transcrip_reg_TACO1-like_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029072">
        <property type="entry name" value="YebC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12532">
        <property type="entry name" value="PTHR12532"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01709">
        <property type="entry name" value="Transcrip_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75625">
        <property type="entry name" value="SSF75625"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01033">
        <property type="entry name" value="TIGR01033"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 4" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH81368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="250" mass="26704" checksum="80BFAB1665A764D6" modified="2015-07-22" version="1">MSGHSKWATTKHKKAVIDAKRGKLFAKLIKNVEVAARQGGADPDGNPTLYDAIQKAKKQSVPNKNIDSAVKRGAGLEAGGAEYETIMYEGYGPNGVAVLIECLTDNRNRAASDVRVAMTRNGGSMADPGSVSYLFNRKGVVIVPKGELSEDDVLAAVLDAGAEEVNDLGESFEVLSEAGDMVAVRTALQDAGIDYDSAEANFVPTMQVELDEEGARKIFRLIDALEDSDDVQNVFANFDVSDEVMEKASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N253</accession>
    <name>A0A0F7N253_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glycine/betaine ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_03890</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014830.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_03890"/>
    <dbReference type="EnsemblBacteria" id="AKH81473">
        <property type="protein sequence ID" value="AKH81473"/>
        <property type="gene ID" value="AA958_03890"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_03890"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.817"/>
    <dbReference type="OrthoDB" id="485527at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007210">
        <property type="entry name" value="ABC_Gly_betaine_transp_sub-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04069">
        <property type="entry name" value="OpuAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="49"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="201"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="239"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="87"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="846"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="848"/>
            <end position="867"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH81473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="876" mass="96192" checksum="94E4EFAB2EA45457" modified="2015-07-22" version="1">MPEIDFGSRVESVVDWLKDHLGWLFDFIDTVLSGMYDGVNAVLDAPEPLVMAGIFAVIAFWLRGPLPAVLAFAGFAVVDSVQLWPEAMETLSMVLVATAITVVIAVPLGIWAARNKVVSTAVRPMLDFMQTMPAFVYLIPGVIFFSIGITPGIIATIVFAMPPGVRMTELGIRQVDAELVEAAEAFGTKPADTLRRVQLPLALPTIMAGVNQVIMLALSMVVIAGMVGGGGLGEVVYNAVTRVAIGTGFESGLVVVILAMYLDRMTSALNQRVSPLGRRALAKTAAAVDRWKFLHYKPTTAIATVGIVVLALLAGGLNLAESDDEGTQEAAAASTDVGEGRKIDIGYIPWDEGIASTFLWKEVLEQRGFEAEAKQLDPGPLFTAVSEGQVDFQTDAWLPVTHEQYWEQFGGKMEDMGSWYGPTTLELSVPSYMKDVTSLEDLKDHKGEFGGKIIGIEASAGMMGILKDKVVGEYGLEDWEVVSSSTSSMLAELERAYQAEEPVVVTLWSPHWAYSKYDMTKLEDPKKAWGSGDDVHTTARKGFAKDEPVVADWLRDFTMKEKELTSLEEMIVDAGEGNEQQAVRDWLEQNEGYVDKMAPLPDGGNGGGTRGKDAGKTVNLGYFPWDEAIASTYLWQNVLEDRGYKTNVKQLDPGPLYTALAEGQMDVQFDAWLPVTHEQYWERFGDNLTDIGSWYGPTTLELSVPSYMKDVKSLEDLKDHKGEFGGKIIGIEASAGMMGILKDKVVGEYGLEDWEVVSSSTSSMLAELERAYDKKEPIVVTLWSPHWAYGKWDLTKLDDPKGAWGEGDDIHTVAKKDFAEDFPEFHEWLKDFTLSEEELSSLEVEIQNGGDGKEKESARKWMDDNPEVIDRIAPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N280</accession>
    <name>A0A0F7N280_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Proteasome subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">20S proteasome alpha subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Proteasome core protein PrcA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">prcA</name>
        <name evidence="5" type="ORF">AA958_03995</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="2">The formation of the proteasomal ATPase ARC-20S proteasome complex, likely via the docking of the C-termini of ARC into the intersubunit pockets in the alpha-rings, may trigger opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein degradation; proteasomal Pup-dependent pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped by the proteasome-associated ATPase, ARC.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014845.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_03995"/>
    <dbReference type="EnsemblBacteria" id="AKH81489">
        <property type="protein sequence ID" value="AKH81489"/>
        <property type="gene ID" value="AA958_03995"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_03995"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.838"/>
    <dbReference type="OrthoDB" id="1243753at2"/>
    <dbReference type="UniPathway" id="UPA00997"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019941">
        <property type="term" value="P:modification-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00289_B">
        <property type="entry name" value="Proteasome_A_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022296">
        <property type="entry name" value="Proteasome_asu_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599:SF69">
        <property type="entry name" value="PTHR11599:SF69"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03691">
        <property type="entry name" value="20S_bact_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2 3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="229"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH81489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="278" mass="29855" checksum="0BEB9A5D603D3457" modified="2015-07-22" version="1">MSTPFYVSPQQAMADRAEYARKGIARGRSVVVLQYSDGILFVAENPSRALHKVSEIYDRIAFAAVGKYNEFENLRIGGVRYADLRGYTYDREDVTARGLANVYAQTLGTIFSSGAEKPYEVELIVAEVGETPADDQIFRLPHDGSIVDEHGSVAVGGNSDQISSYLDQRHREGMTLAEGLKLAAESLARDNNGGERELTSKQLEVAVLDRNRPQQRKFRRILGSQLARLLEEDGEGPAGASGAEDGEDTAAEADGGAEGAGSADGTAKKPGNGSGKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2B7</accession>
    <name>A0A0F7N2B7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">Undecaprenyl-diphosphatase</fullName>
            <ecNumber evidence="4 14">3.6.1.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13 14">Bacitracin resistance protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12 14">Undecaprenyl pyrophosphate phosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">uppP</name>
        <name evidence="15" type="ORF">AA958_01210</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>di-trans,octa-cis-undecaprenyl diphosphate + H2O = di-trans,octa-cis-undecaprenyl phosphate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:28094"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60392"/>
            <dbReference type="EC" id="3.6.1.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Cell membrane</location>
            <topology evidence="14">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="14">Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the UppP family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.27" evidence="4 14"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014377.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_01210"/>
    <dbReference type="EnsemblBacteria" id="AKH81012">
        <property type="protein sequence ID" value="AKH81012"/>
        <property type="gene ID" value="AA958_01210"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_01210"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.266"/>
    <dbReference type="OrthoDB" id="1826154at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050380">
        <property type="term" value="F:undecaprenyl-diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016311">
        <property type="term" value="P:dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01006">
        <property type="entry name" value="Undec_diphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003824">
        <property type="entry name" value="UppP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30622">
        <property type="entry name" value="PTHR30622"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02673">
        <property type="entry name" value="BacA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00753">
        <property type="entry name" value="undec_PP_bacA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="6 14" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-0133">Cell shape</keyword>
    <keyword evidence="14" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8 14 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="226"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AKH81012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="289" mass="31014" checksum="6887DAA15B391C08" modified="2015-07-22" version="1">MSWIEAVILGLVQGLTEFLPISSSAHLRLTAAFAGWEDPGAAFTAITQIGTETAVLIYFRKDIARIVSAWCRSLTNKAMRSDHDAKMGWLVIVGSIPIGVLGLTFQESIEGPFRDLRLIATTLIVMGLLLGFADWRASTGGGRHRAAVKRKELTDLNTRDGLLFGFAQALALVPGVSRSGATITGGLFLNYNREAAARYSFLLAIPAVLASGLFELRKVPGATHMNWGATVAGTVIAFLVGYAVIAWFMKFITTRSFAPFVIYRVLLGILIFALVATGALDPEAGDAAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2I6</accession>
    <name>A0A0F7N2I6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_04630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_04630"/>
    <dbReference type="EnsemblBacteria" id="AKH81598">
        <property type="protein sequence ID" value="AKH81598"/>
        <property type="gene ID" value="AA958_04630"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_04630"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.976"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH81598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="83" mass="9059" checksum="2015A7BBA4D670F9" modified="2015-07-22" version="1">MRGKARVPAINCGSTASRARVDRHLAVLGGPAAPQGDTDSATMLMRELTAREERAAKPGRMARVSLFAPLRKLRRTLFGNRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2L3</accession>
    <name>A0A0F7N2L3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF1080 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_08385</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015595.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_08385"/>
    <dbReference type="EnsemblBacteria" id="AKH82246">
        <property type="protein sequence ID" value="AKH82246"/>
        <property type="gene ID" value="AA958_08385"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_08385"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1771"/>
    <dbReference type="OrthoDB" id="1452706at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010496">
        <property type="entry name" value="3-keto-disaccharide_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028871">
        <property type="entry name" value="BlueCu_1_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06439">
        <property type="entry name" value="DUF1080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00196">
        <property type="entry name" value="COPPER_BLUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519056" description="DUF1080 domain-containing protein" evidence="2">
        <location>
            <begin position="37"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1080" evidence="3">
        <location>
            <begin position="435"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="596"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH82246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="643" mass="68925" checksum="501919DF49307A7D" modified="2015-07-22" version="1">MRSGALTAGGLRRALIILVAVCLALLAPGGLPTAGAAAPDEARAAQTLTWTAGDSITEYTSAPTTAVAGETTIVFENSAATGNTTGMVHTLTFDTFSDGYNKDVSLNLQASPNDENNGKWQATVNLSPGKYRYFCAIPGHGSMAGELIVTDGGGEDTTAPETAAEVKGEQDANGAYLGSATVELSATDDMSGVDRVDYALDGATDWTAYEAPVVVNTPGEHTVRYRATDKAGNTSEEKSVTFTVTEANDTTPPTVTATVSGERNGDGAYLDMAMVTLNGADTGGSGLDRVEYSVGGSAFQRYTEMLHVMTVGEHTVSYRATDKAGNSSEVGTVTFTIVEKYPNPDPDCPELDSRPIVFIGQYDTHVPNRVTANGCTINEVIEDEKAWPKQKAFLDHVRDVTDELYADAVINGEERQIIRDTARESGIGKPGQNDGYTPIFTGTENSFSKWQQVGGGSFNLNEDGSMTSGTTVDGMGMLWYPQAQYGDFSLKLQWRDDAPGTGRANSGVFVRFPDVRDHPDESRPEWVAIKYGHEVQVFDSEAGDQYKTGSVYGFDRVDHGSAGVVPKGTWNDYEIRVVGQKYSIYRNGVLLNEFENSPGQLFSPPRGDDPGTDGRQHAKGYIGLQVHGTTDVVSFRDIRIKPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2V2</accession>
    <name>A0A0F7N2V2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_05480</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015093.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_05480"/>
    <dbReference type="EnsemblBacteria" id="AKH81739">
        <property type="protein sequence ID" value="AKH81739"/>
        <property type="gene ID" value="AA958_05480"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_05480"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1149"/>
    <dbReference type="OrthoDB" id="1619224at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="284"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="92"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH81739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="316" mass="34411" checksum="D9E8B9C7CFB6C889" modified="2015-07-22" version="1">MAQAVARPPGTARRRAESRRGGGRRGGSRRLPYLLIAPAGLLMLGFIAYPMLSVFSYSLRHYNVTKPWRDGFAGLENFTTLLTDDPLFWDSLAFSAKWVVVEVGLQLAFGLALALIVNQTFLGRAFARALVFSPWAVSGVLTTTIWMLLYNPATGVSRYLADAGIGSYGTSVLSDTGTVFWAAVLAELWRGVPFFAILILADLQSVPKDLYEAAAVDGAGRLRQFVHITLPHLRDAIILSTLLRAVWEFNNVDLLYTLTGGGPAGETTTLPLYVANTGIHGHDFGYASALTTVAFVILLFCSILYLRLSKFGGDNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2X1</accession>
    <name>A0A0F7N2X1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_05450</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015087.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_05450"/>
    <dbReference type="EnsemblBacteria" id="AKH81733">
        <property type="protein sequence ID" value="AKH81733"/>
        <property type="gene ID" value="AA958_05450"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_05450"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1143"/>
    <dbReference type="OrthoDB" id="558559at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904823">
        <property type="term" value="P:purine nucleobase transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045018">
        <property type="entry name" value="Azg-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43337">
        <property type="entry name" value="PTHR43337"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="152"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="271"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="362"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="419"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="458"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH81733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="482" mass="50187" checksum="B442B96ADFB2A2DE" modified="2015-07-22" version="1">MSEQIADKSPSPAPGSGGLESFFRIRERGSTVGREIRGGLATFFTMAYILVLNPIILSGAEDKYGNQLDFGQLVTVTALVAAVMTVLMGVTANLPLALAAGLGINAVVAYQIAPLMTWPDAMGLIVLEGIIVCLLAATGVREAVMHAIPQPLKVAISVGIGMFIALIGFIDAGFATRIPDVADTTVPLQLGSTGSLSGWPVLVFCAGVLLTVSLLARGVKGAILISILAMTVVAIVINSVADVADETWGLTVPDWPGDVVEAPDFGLLGEFSFFGAFDEVSAVTVVLLVFTLFLTDFFDTMGTAVGVTSEAGLLDEQGRVPRLGRLLFVDGLATVFGGAASGSSSTSYIESAAGVGEGARTGLANLVTGGLFALALLFTPLALVVPSQAAAPALIAVGFLLMTQVRHVDWTRYEIAVPAFLTIAVMPFTYSITNGLGAGFIAYVLLQTVMGRARKVHPLMWAVSVLFVVYFAIEPIEDLLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N384</accession>
    <name>A0A0F7N384_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Galactonate dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_03025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014680.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_03025"/>
    <dbReference type="EnsemblBacteria" id="AKH81317">
        <property type="protein sequence ID" value="AKH81317"/>
        <property type="gene ID" value="AA958_03025"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_03025"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.645"/>
    <dbReference type="OrthoDB" id="1825548at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008869">
        <property type="term" value="F:galactonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009063">
        <property type="term" value="P:cellular amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034194">
        <property type="term" value="P:D-galactonate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023592">
        <property type="entry name" value="Galactonate_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018110">
        <property type="entry name" value="Mandel_Rmase/mucon_lact_enz_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034593">
        <property type="entry name" value="Mandelate_racemase_DgoD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013341">
        <property type="entry name" value="Mandelate_racemase_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48080">
        <property type="entry name" value="PTHR48080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02746">
        <property type="entry name" value="MR_MLE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00003">
        <property type="entry name" value="D-galactonate_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="SSF54826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00908">
        <property type="entry name" value="MR_MLE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00909">
        <property type="entry name" value="MR_MLE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MR_MLE" evidence="1">
        <location>
            <begin position="126"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="382" mass="41381" checksum="E8DCEAD9D77D339F" modified="2015-07-22" version="1">MKITRVETFAVPPRWLFCRIETDDGLVGWGEPVVEGRAATVRTAVHELAEQFLLGADPLRIEDHWQLMTKGSFYRGGPVLSSAVAGLDQALWDLAGKAFGAPVHQLLGGPVRERARAYCWVGGDEPGEVRDQVAAQVEAGFTAVKMNGSGRMDRLPNVAELRRVAARAEAARDALGPERDFAVDFHGRFSAAGAIKAIGVLEPYAPMFVEEPVLPEHTHLLERVTGSTALPVATGERLFSRAEMLPALRAGVAVLQPDLSHAGGISECRRIASLAETFDVAIAPHCPLGPLALAASLQLAFYTPNFLIQEQSIGIHYNTGAELLDYVADPEVFRFHDGHLLRPAGPGLGVEIDERAVRAADGTAESWHNPVWRHPDGSYAEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N391</accession>
    <name>A0A0F7N391_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UDP-glucose:polyglycerol phosphate glucosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_05990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015181.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_05990"/>
    <dbReference type="EnsemblBacteria" id="AKH81828">
        <property type="protein sequence ID" value="AKH81828"/>
        <property type="gene ID" value="AA958_05990"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_05990"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1252"/>
    <dbReference type="OrthoDB" id="635734at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="214"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="393" mass="43891" checksum="4E348800203DF239" modified="2015-07-22" version="1">MKIRYLLMHAYGTGGTIRTVFNQAGSMAAAGHDVEIASMQRTRDEPHFPLHPKVTITTLVDQRPGAREAELAAAGARAAEKRVEREGQPPRHIPSGEFAYERYNRYIEDTVIDWLERQHDAVIVPTRPGLNFLTARFTPRSCHKIAQEHMNLGTHPSDIRAAIQREYPRFDAVAVLTHGDREDYQELLPGTRVVRIPNAVHTGDKKLTTYAAHVAVAAGRLFPQKGFDMLIPAWAQLVEKFPDWQLRIFGTGEKKAELRRLINENHLYNHVFLMGHTHKLDDELARASFYVLSSRFEGLPMVMIESMTHGLPVVSFDCPTGPADVLTHGKDGLLVPRKDVDGLAEAMGQLMDDEGLRADMGAAALQTSRSYTPEAVHPQWEALFEEIHGSGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3G7</accession>
    <name>A0A0F7N3G7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Endoribonuclease L-PSP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_06365</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015246.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_06365"/>
    <dbReference type="EnsemblBacteria" id="AKH81893">
        <property type="protein sequence ID" value="AKH81893"/>
        <property type="gene ID" value="AA958_06365"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_06365"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1329"/>
    <dbReference type="OrthoDB" id="1850770at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="SSF55298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH81893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="140" mass="14748" checksum="B7573AB4B169EEE8" modified="2015-07-22" version="1">MAGGGVRRISSGAPWEEEFGYSRAVELPNGLVLVAGCTSVVDGVIVGEGDPHIQAMTAFGVAFEALKRVGLEREDVVRTRMFLTHARDVEAVGGAHKELFGTIRPAASLIIVSGFVDPRLVVEVEVEAYRPGGSREAAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3J1</accession>
    <name>A0A0F7N3J1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Holliday junction ATP-dependent DNA helicase RuvA</fullName>
            <ecNumber evidence="8">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ruvA</name>
        <name evidence="11" type="ORF">AA958_03295</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Forms a complex with RuvB.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the RuvA family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="8"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014726.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_03295"/>
    <dbReference type="EnsemblBacteria" id="AKH81367">
        <property type="protein sequence ID" value="AKH81367"/>
        <property type="gene ID" value="AA958_03295"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_03295"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.701"/>
    <dbReference type="OrthoDB" id="1370858at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009379">
        <property type="term" value="C:Holliday junction helicase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14332">
        <property type="entry name" value="UBA_RuvA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00031">
        <property type="entry name" value="DNA_helic_RuvA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013849">
        <property type="entry name" value="DNA_helicase_Holl-junc_RuvA_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000085">
        <property type="entry name" value="RuvA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011114">
        <property type="entry name" value="RuvA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036267">
        <property type="entry name" value="RuvA_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07499">
        <property type="entry name" value="RuvA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01330">
        <property type="entry name" value="RuvA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46929">
        <property type="entry name" value="SSF46929"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00084">
        <property type="entry name" value="ruvA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 8" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 8 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="HhH1" evidence="10">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="HhH1" evidence="10">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AKH81367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="207" mass="21287" checksum="F58A345988BC1011" modified="2015-07-22" version="1">MIAFVSGPVAALAPDAAVIEVGGIGMAVQCTPDTLSTLRVGKDARLATSLVVREDSLTLYGFADDDERQVFELLQTASGVGPRLAQAMLAVHRPDALRLAVSTGDEKALTAVPGIGKKGAQKLLLELKDRLGEPLGSSGLAGRQAGAAAAAGWREQLHAALTGLGYAPREADEAVTAVAPQAEEDGAAPPPLPQLLRAALQTLNRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3M5</accession>
    <name>A0A0F7N3M5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF397 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_10845</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015981.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_10845"/>
    <dbReference type="EnsemblBacteria" id="AKH82641">
        <property type="protein sequence ID" value="AKH82641"/>
        <property type="gene ID" value="AA958_10845"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_10845"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2281"/>
    <dbReference type="OrthoDB" id="1996962at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="14"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="68" mass="7321" checksum="4A7FC8EED5DA0015" modified="2015-07-22" version="1">MSTAKAEAQVPGLSWAKSSYSSSEGGDCIEVAPTPHTVHVRDSKDPEGPILRFTPDAWAEFVAYARTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3Q6</accession>
    <name>A0A0F7N3Q6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cold-shock protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_14875</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016605.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_14875"/>
    <dbReference type="EnsemblBacteria" id="AKH83290">
        <property type="protein sequence ID" value="AKH83290"/>
        <property type="gene ID" value="AA958_14875"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_14875"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3135"/>
    <dbReference type="OrthoDB" id="2034748at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012156">
        <property type="entry name" value="Cold_shock_CspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019844">
        <property type="entry name" value="CSD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002599">
        <property type="entry name" value="Cold_shock_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00050">
        <property type="entry name" value="COLDSHOCK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00352">
        <property type="entry name" value="CSD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="3">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH83290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="67" mass="7294" checksum="14D9F7E32C307716" modified="2015-07-22" version="1">MANGTVKWFNSEKGFGFIAQDGGGADVFAHHSNIDAQGFRELVEGQQVEFDVVQGQKGLQAENIRIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N407</accession>
    <name>A0A0F7N407_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Extradiol dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_15465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016687.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_15465"/>
    <dbReference type="EnsemblBacteria" id="AKH83375">
        <property type="protein sequence ID" value="AKH83375"/>
        <property type="gene ID" value="AA958_15465"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_15465"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3255"/>
    <dbReference type="OrthoDB" id="2035522at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="3"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="135" mass="14909" checksum="38FE4EA819938A47" modified="2015-07-22" version="1">MPHKIFVNLPVKDLNRSMAFFTALGYRFDENFTDENATCLVISDDIYAMLLTEPFFKGFTKKEIADTGTSTEAILALSVDNREAVDEIVDKALAAGGGVANEPNDQGFMYGRSFLDPDGHQWEIFWMDPSAAASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4I3</accession>
    <name>A0A0F7N4I3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F5/8 type C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_08585</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015627.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_08585"/>
    <dbReference type="EnsemblBacteria" id="AKH82279">
        <property type="protein sequence ID" value="AKH82279"/>
        <property type="gene ID" value="AA958_08585"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_08585"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1811"/>
    <dbReference type="OrthoDB" id="419160at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006103">
        <property type="entry name" value="Glyco_hydro_2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02836">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519233" description="F5/8 type C domain-containing protein" evidence="2">
        <location>
            <begin position="46"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="3">
        <location>
            <begin position="478"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH82279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="616" mass="65027" checksum="8574B9947094E25A" modified="2015-07-22" version="1">MHPRPPAPPGAARPRRARGLPAALPAVLAAGALLAGLTTALPAAAVQPAPEPASVTAPAPAAAAPEAAAGSVVKVTGPPGAWQLTVDGQPYTVKGLTWGPPVAEAASYMPDVASLGANTVRTWGTDATTRPLLDAAAANGVKVIAGFWLQPGGGPGSGGCVDYVADTAYKNDMLAEFPRWVDTYRDHPGVLMWNVGNESVLGLQNCYQGAELERQRDAYTGFVNDVAERIHQVDPNHPVTSTDAWVGAWPYYQRNAPDLDLYAVNAYAAVCDVRAAWEAGGYDKPYIVTEGGPPGEWEVEDDANGVPTEPSDVAKAEGYGRAWDCVTGHRGVALGATLFHYGVENDFGGVWFNLTPDKQRRLSYYAVKEAYGRDTGGDNTPPVISGLRVGDAGAVPAGREFTLSADIADPDGDALAYGVLVNSNYVDQDKALRPAQFRQTGAGTFAVTAPDRLGVWKVYLRATDGRGNVGIETLSVKVVPPPVDGTNVARGKPSTASTEQTDAYGGCPCEAGDATDGSYTTRWASAWADPQWLSVDLGERTTFTHVQLAWEAAFARSYAIQVSDDGQDWRTVYETTAGNGGIDDLEVSGTGRYVRMNGTARGTGYGYSLYEFGVYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4N6</accession>
    <name>A0A0F7N4N6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_08970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH82338">
        <property type="protein sequence ID" value="AKH82338"/>
        <property type="gene ID" value="AA958_08970"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_08970"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1889"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="60" mass="6596" checksum="5E0326A9D85EF579" modified="2015-07-22" version="1">MVYEHLSPQPELLQAIEAEPDDSGQPHRSRGVGIRRRTAAADRFRGDPDSVPTPERGDSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4R0</accession>
    <name>A0A0F7N4R0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA polymerase I</fullName>
            <ecNumber evidence="7">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">polA</name>
        <name evidence="10" type="ORF">AA958_06015</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the DNA polymerase type-A family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="7"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_06015"/>
    <dbReference type="EnsemblBacteria" id="AKH81832">
        <property type="protein sequence ID" value="AKH81832"/>
        <property type="gene ID" value="AA958_06015"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_06015"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1257"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09898">
        <property type="entry name" value="H3TH_53EXO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020046">
        <property type="entry name" value="5-3_exonucl_a-hlix_arch_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002421">
        <property type="entry name" value="5-3_exonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001098">
        <property type="entry name" value="DNA-dir_DNA_pol_A_palm_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020045">
        <property type="entry name" value="DNA_polI_H3TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018320">
        <property type="entry name" value="DNA_polymerase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002298">
        <property type="entry name" value="DNA_polymerase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10133">
        <property type="entry name" value="PTHR10133"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01367">
        <property type="entry name" value="5_3_exonuc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02739">
        <property type="entry name" value="5_3_exonuc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00476">
        <property type="entry name" value="DNA_pol_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00868">
        <property type="entry name" value="DNAPOLI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00475">
        <property type="entry name" value="53EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00482">
        <property type="entry name" value="POLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="SSF47807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00593">
        <property type="entry name" value="pola"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 7" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="3 7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="53EXOc" evidence="8">
        <location>
            <begin position="9"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="POLAc" evidence="9">
        <location>
            <begin position="660"/>
            <end position="867"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AKH81832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="904" mass="98491" checksum="D3E36ADF8A1D76AA" modified="2015-07-22" version="1">MAENGSKTHRPRLMLLDGHSLAYRAFFALPAENFSTVGGQVTNAIYGFTSMLSNTLRDEAPTHLAVAFDVSRKTWRSAEFADYKANRSSTPDDFKGQVELIGELLDAMNVPRFAVEGFEADDVIATLATQAEAAGFEVLIVTGDRDSFQLVSDQVTVLYPTKGVSELTRFTPEKVEERYGLTPAQYPDFAALRGDPSDNLPGIPGVGEKTAAKWIKQFGSFAELAERAEEVKGKAGQNLRDHLDAVKLNRRLTELDRAVELPARPEELERKPYDRTALQVVMDALEFRNPNFRERLFNADPGAAEAVVEPEPGVQVDGRVLATGELAPWLAEHGSVPLGMATVGTWQLGVGSVSEVALATAEGPAAWFDPARLDAADEQAFAGWLADPGSAKTVHDAKSAMRVFAEHGWTVEGVAMDTALAAYLVTPGRRTFALDALSIAYLGRELEPPAADGQLELGLDGAEGDQEAAERDALMRTARTVLDLGEALSEKLAQVGAAELLGDMELPVSAVLAGMERAGVAVDRAHLVAMEEQFAGAVQQAVREAHDAVGHEFNLGSPKQLQEVFFGELDLPKTKKTKTGYTTDADALAWLATKTDHELPVIMLRHREQARLRSTVEGLIKTIAADGRIHTTFSQTVAATGRLSSTDPNLQNVPIRTDEGRAIRRGFVVGEGYESLLTADYSQIELRVMAHLSEDEGLIEAFTSGEDLHDTVASQVFAVPRTEVDAEMRRKIKAMSYGLAYGLSAFGLSQQLGIEAAEARKLMENYFERFGGVRDYLRHVVDEARATGYTETMFGRRRYLPDLNSDNRQRREMAERMALNAPIQGTAADIVKLAMLRVDRALTAASLETRLLLQVHDEVVLEVAPGEREQVEELVRREMAGAVSLRAPLDVAVGVGPDWESAAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N500</accession>
    <name>A0A0F7N500_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">4-alpha-glucanotransferase</fullName>
            <ecNumber evidence="3">2.4.1.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Amylomaltase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Disproportionating enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_09810</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Transfers a segment of a (1-&gt;4)-alpha-D-glucan to a new position in an acceptor, which may be glucose or a (1-&gt;4)-alpha-D-glucan.</text>
            <dbReference type="EC" id="2.4.1.25"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the disproportionating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.25" evidence="3"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015820.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_09810"/>
    <dbReference type="EnsemblBacteria" id="AKH82478">
        <property type="protein sequence ID" value="AKH82478"/>
        <property type="gene ID" value="AA958_09810"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_09810"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2067"/>
    <dbReference type="OrthoDB" id="814704at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004134">
        <property type="term" value="F:4-alpha-glucanotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102500">
        <property type="term" value="F:beta-maltose 4-alpha-glucanotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003385">
        <property type="entry name" value="Glyco_hydro_77"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32438">
        <property type="entry name" value="PTHR32438"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02446">
        <property type="entry name" value="Glyco_hydro_77"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH82478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="705" mass="74282" checksum="31DD7697B739378E" modified="2015-07-22" version="1">MSLARLAALHGVAVSYARTPGRAVQVPEGTLVAVLAALGVDAAGPAAVAASLAAYEAAERDRLLPATLVPRAGTVLDPGPLPPGTATALAGEDGAELDPRAPLPPGVHTLTATAPDGRTGKASVIAAPARVPQPARRGAGLALPLPALLSTRSWGMGDLGDLAELAAWSARTHGLDFVQLGPLHAAVPGTAGRPADPSPYLPSSRRFTDPVHLRIEDIPEYRYLAPDDRAQAAELAGRAAALRDQVRAKGGLVDRDEVWRLKRAALELLLRVELTPGRRVAYHHFLAEQGQPLDDYAAWCALAEIHGPDWRSWPGGLSDPRSNATTRARHDLLDRIDFHCRLAWLTDNQLWRAQRIARDAGMAVGVIHDLVAGVHPSGADAWAEQSVLAAGCTAGTAPRDGDARGTDRGVPVWRPDRLAAAGYGPYRSVLRAALRRAGALRVGHVGGLFRQWWVPAGRPPAEGTYVSYDAEAMLGVLALEAHRAGTPVIGDDQEDPAEPAVRDALAARGVLGTSALWTQREPAPETPGGVPCPRPPERWRADALASVTGHGLPPTAARLSGAHLTLRHELGLVEGPLPAARAADAVEVGAWLDLLDRLRLLPGGRADEASVITGLYRFLARTPARLVAVWLPDAVGDRRPQHVPGAGAAYPGWRLPVADPDGRTVLLEELADAPRTHRLLAEVVRELGGRAGARPGGTSEEAPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N531</accession>
    <name>A0A0F7N531_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_09865</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015831.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_09865"/>
    <dbReference type="EnsemblBacteria" id="AKH82489">
        <property type="protein sequence ID" value="AKH82489"/>
        <property type="gene ID" value="AA958_09865"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_09865"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2078"/>
    <dbReference type="OrthoDB" id="1675228at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="246"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="474"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH82489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="501" mass="53238" checksum="AF5A00CA8180113A" modified="2015-07-22" version="1">MTYPPPAGSAAPPEHRTAPAFPAQAGPDGPLVPQPGSPAGGSAAPPPPAVPPGRRSAFAEGVDRLRAAATTEPGRLRIIGAVLAALVVLFGALTAWQVSDRAAAADDVINRSQPLSADAADIYRSLAGANTTAATGFLEGGQEPPKVRERYDADIQQASRLLVKAAANSQGAAESQKQIEKLNQALPVYTSLVETARANNRQGLPLGGAYLRYADEQMRETLLPAAEQLYLSETGQLEQDYSDAKAWPWAALAGGLLALGVLFWAQRRHYLRTNRVFNHGLLAASAATVIVLLWLTVGHTFARSGLGDSDRHGAQSLHALNEARINTLRARADENLTYVNRGSVTTEDGLDKYEDSYLKGMSELAGKSPDAEEAPGQSLLGRALELADDDQGREPVAEAVDNVREWRKLHGEAQAKNVAGEYEEAKDLVIGGDGEKSTSEFFDQVDDSLKEALDHERREFRSAAEDGRGALSGLWIGAGVLAVLGAAGAVFGIGRRLSEYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N580</accession>
    <name>A0A0F7N580_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Copper-transporting ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_10210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015881.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_10210"/>
    <dbReference type="EnsemblBacteria" id="AKH82539">
        <property type="protein sequence ID" value="AKH82539"/>
        <property type="gene ID" value="AA958_10210"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_10210"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2150"/>
    <dbReference type="OrthoDB" id="2061355at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006825">
        <property type="term" value="P:copper ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000428">
        <property type="entry name" value="Cu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00944">
        <property type="entry name" value="CUEXPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="SSF55008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMA" evidence="1">
        <location>
            <begin position="8"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="75" mass="7542" checksum="AEA8DAC82E25138D" modified="2015-07-22" version="1">MSTQTSVTTVYKVTGMTCGHCEGAVSAEISEIDGVSSVKAAAATGEVTVTSATPLDEEKVRAAVDEAGYELTGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5U8</accession>
    <name>A0A0F7N5U8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AMP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_08055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015542.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_08055"/>
    <dbReference type="EnsemblBacteria" id="AKH82192">
        <property type="protein sequence ID" value="AKH82192"/>
        <property type="gene ID" value="AA958_08055"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_08055"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1699"/>
    <dbReference type="OrthoDB" id="961884at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="44"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="539" mass="59380" checksum="D00D7234D1B1C68D" modified="2015-07-22" version="1">MPKNPRPKNIGLLFEHYAGAPAPEWHLDIPFSIAPDTRTHDATSLANLVSDMSGRLKAAGLRRGDRVALVKNNHLDTIVLAAAVARLGALPAMITSTFDSETLARMMPRLEPKLLVASEEVLGAADRAGIKLVDKSTRVVCVDGAPDSPSGVTPLAEFAGADVPQPDIVDNSEPMLCTHTSGTTGVPKFVAHSANTLLGVLSKLETLRIPFLSTRPDDTIASCIAFVHSRAVTWTFAQFALPPAKAVVLSQADPSTVVETLSKHRPTTLEACPNIYQLWEHLIRTNPELFTHIRAYLSTFDAIHPSTVRAFMAATKRRGAVWGQSWGQSEIGPATLAVYPKRKVMRSEGSRGGPITNNVGRPIPFVTRIRVVDPETRKPKRRGQRGLVLIRTKGRCLTYLGEPERHREKDWNGWWNTGDIGVHTRTGSLEILDREVDSIPGMSSLELESLLIERLDPVTEAIVLGNPNGLPLPVISTYDGSPLDPQEWRRATADLPELDEPRVIPWEDFPRTGTWKVRRPQLRNRMLNSEETFGTGRWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5W0</accession>
    <name>A0A0F7N5W0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Tellurium resistance</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_08120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015552.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_08120"/>
    <dbReference type="EnsemblBacteria" id="AKH82202">
        <property type="protein sequence ID" value="AKH82202"/>
        <property type="gene ID" value="AA958_08120"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_08120"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1711"/>
    <dbReference type="OrthoDB" id="1437267at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd06974">
        <property type="entry name" value="TerD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003325">
        <property type="entry name" value="TerD"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH82202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="244" mass="27309" checksum="86CD242CBA9E16AC" modified="2015-07-22" version="1">MSFWGNWRREGVPQFDSAGASYSVQLTKRKPLLSLSRQGSDTGNLRINLSWRMRTSDLGGRSRRSGGTLLHPAKLFRPEIVQAQGPAVVNVDLDLACMYELEDGTKGVVQPLGNLLGDINDPPYIKLSGDDRFGSGSGETVYVNLDHKEAFRRLLVFVYIYDGTPAFDRTQAVVTLYPSSGPRVEIALDERAPEARSCAVLLIENKKGELTVRREVRYVYGFQSELDRLYGWGLVWGRGYKTKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N676</accession>
    <name>A0A0F7N676_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Trans-aconitate 2-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.144</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">tam</name>
        <name evidence="3" type="ORF">AA958_12045</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-adenosyl-L-methionine + trans-aconitate = (E)-3-(methoxycarbonyl)pent-2-enedioate + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:14969"/>
            <dbReference type="ChEBI" id="CHEBI:15708"/>
            <dbReference type="ChEBI" id="CHEBI:57470"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.1.1.144"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. Tam family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.144" evidence="1"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016179.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_12045"/>
    <dbReference type="EnsemblBacteria" id="AKH82844">
        <property type="protein sequence ID" value="AKH82844"/>
        <property type="gene ID" value="AA958_12045"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_12045"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2534"/>
    <dbReference type="OrthoDB" id="1739932at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030798">
        <property type="term" value="F:trans-aconitate 2-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00560">
        <property type="entry name" value="Tran_acon_Me_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023506">
        <property type="entry name" value="Trans-aconitate_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023149">
        <property type="entry name" value="Trans_acon_MeTrfase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="2">
        <location>
            <begin position="39"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH82844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="265" mass="28757" checksum="52A3FFBE49F780DC" modified="2015-07-22" version="1">MTSPSWDPQQYLRHEGPRTRPLADLLARVGELPGRPPRIADIGCGTGNGTALLAARWPAAHVTGYDSSAAMLRTAAAHAGPTSGGGRIDFAHADLTDWTPEPGAYDLILGNAVLQWVPDHWEHFPRWLAGLAPGGTFAFQVPGNYDAPSHALMRQLTRDPRWRERLRGVLRDQPVLQPVAYLELLCDLGCAGDAWETTYTHLLHGPDPVLDWVKGTGLRPVLDALGDDADAFVTAYAALLRTAYPPGPHGTPFPFRRIFALGVTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6K1</accession>
    <name>A0A0F7N6K1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Beta-xylanase</fullName>
            <ecNumber evidence="6">3.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AA958_13165</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-xylosidic linkages in xylans.</text>
            <dbReference type="EC" id="3.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glycosyl hydrolase 10 (cellulase F) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.8" evidence="6"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016355.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_13165"/>
    <dbReference type="EnsemblBacteria" id="AKH83023">
        <property type="protein sequence ID" value="AKH83023"/>
        <property type="gene ID" value="AA958_13165"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_13165"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2770"/>
    <dbReference type="OrthoDB" id="654705at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031176">
        <property type="term" value="F:endo-1,4-beta-xylanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030247">
        <property type="term" value="F:polysaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001919">
        <property type="entry name" value="CBD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008965">
        <property type="entry name" value="CBM2/CBM3_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012291">
        <property type="entry name" value="CBM2_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044846">
        <property type="entry name" value="GH10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031158">
        <property type="entry name" value="GH10_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001000">
        <property type="entry name" value="GH10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31490">
        <property type="entry name" value="PTHR31490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00553">
        <property type="entry name" value="CBM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00331">
        <property type="entry name" value="Glyco_hydro_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00134">
        <property type="entry name" value="GLHYDRLASE10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00637">
        <property type="entry name" value="CBD_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00633">
        <property type="entry name" value="Glyco_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49384">
        <property type="entry name" value="SSF49384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51173">
        <property type="entry name" value="CBM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00591">
        <property type="entry name" value="GH10_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51760">
        <property type="entry name" value="GH10_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 6 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519308" description="Beta-xylanase" evidence="7">
        <location>
            <begin position="33"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="GH10" evidence="9">
        <location>
            <begin position="49"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="CBM2" evidence="8">
        <location>
            <begin position="367"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AKH83023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="469" mass="49548" checksum="129ACD8DC0F772EB" modified="2015-07-22" version="1">MRRLRSRPRALLAALAGALCLYGLGTAAPAQAAAPAEAAGAAGPSATAAASLNELAQAHGKFIGSAAATAHFSDTQYTGILGSEFGQVTAENEMKWDTVESSRGQFNFGPGDRIVDFAQQNGQSIRGHTLVWHNQLPGWVSSLPSGEVRTAMENHVTQVAGHYAGDIDAWDVVNEPFNEDGTFRNSPFYNAMGTDFVAHALRAAKAADPGAKLCINDYNIEGVNAKSTAMYNLVRDLKAQGVPIDCVGIQGHLAIQYGFPNDLRQNMQRFADLGVDVAITELDVRIQLPVSSEKEATQSQYYANVIDACLAVTRCTGVTVWGFPDKYSWVPDVFPGEGSATLWNDSYQPKQAYNAVVEALGGDPGPGPGPGDGCTAAYAVPQQWNGGFTAAVTVSCDGDSLSGWSVSWDYTAGQRVTNAWNATCQQSGTRVTCTNAPYNGTVPDGGSVTFGFNGTWTDTNPTPPTLTLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6N7</accession>
    <name>A0A0F7N6N7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_09730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Streptomycetales</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015805.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_09730"/>
    <dbReference type="EnsemblBacteria" id="AKH82462">
        <property type="protein sequence ID" value="AKH82462"/>
        <property type="gene ID" value="AA958_09730"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_09730"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2049"/>
    <dbReference type="OrthoDB" id="1483891at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="360" mass="38560" checksum="69F79569B0CDA22D" modified="2015-07-22" version="1">MNANSASPAPLSPRPLREAAGARDQVMTARQLREHGIAAADAAQRCRPGGPWQQLLPGVYLLHAGPPTPAERLHAALLYAGRPPGRPAVPAQTRGRTASAPAQDAEPAPYGDAMITGLAALALHGFTTAPPLLALDRIDVLLPRTRRLRSTGSVRLVRAHTLPRPDRITGLPVAPVPRALADTVAVLTDAADVHRLLTEAVHGGHCEATAVVRELSRARLLGRAHVIDAVDTLIAEGRALAEGRLYAMVDAHALPDPLWNVDLRLPGGPHLGGVDAYWPDHAVAVEIDARTPRRTSHDDEALWSPYARKRETLERLGITVVHVTPRALREAPEQQAEVVRAAMTASAERDHATHVVVLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6Q3</accession>
    <name>A0A0F7N6Q3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_13500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016408.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH83078">
        <property type="protein sequence ID" value="AKH83078"/>
        <property type="gene ID" value="AA958_13500"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_13500"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2840"/>
    <dbReference type="OrthoDB" id="1941671at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH83078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="98" mass="10845" checksum="C1775414210BFF6A" modified="2015-07-22" version="1">MSDLYIDNEMLTRVRHNLAHIGEVLDKPARAMADVDARAMGASALERRMDEFGDEWSYGFGQLRKFAKGAVEALDQIEKGFADLDKDLAAALSEAAQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6X9</accession>
    <name>A0A0F7N6X9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">XRE family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_13820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016463.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_13820"/>
    <dbReference type="EnsemblBacteria" id="AKH83134">
        <property type="protein sequence ID" value="AKH83134"/>
        <property type="gene ID" value="AA958_13820"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_13820"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2910"/>
    <dbReference type="OrthoDB" id="1060221at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="20"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="286" mass="31723" checksum="6EAA9B1FCD8C68C8" modified="2015-07-22" version="1">MAVDGSSGSVVRRILLGSQLRRLREEQGISRDAAGYAIRASESKISRMELGRVSFKSRDVEDLLTLYGVTDQTERDALVGLVSEANTAGWWHSYSDVLPGWFPTYVGLESAAAGIDVYEVQFVHGLLQTEDYAHAVVTAGLPISPAEADKRVGARLERQKRLYAEHPAQLRAVLDEAALSRPYGGRQVMRKQLQHLLDASEMPNVSLRIIPLAQHGHTPDSGAFTILSFPEKDLSDVVYVEHLTSALYLDKPEDVATYTKAMDLLRVAAQDESESRELLHRLIREV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N712</accession>
    <name>A0A0F7N712_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NlpC/P60 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_21645</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017632.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_21645"/>
    <dbReference type="EnsemblBacteria" id="AKH84370">
        <property type="protein sequence ID" value="AKH84370"/>
        <property type="gene ID" value="AA958_21645"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_21645"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4558"/>
    <dbReference type="OrthoDB" id="682655at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519127" description="NlpC/P60 domain-containing protein" evidence="4">
        <location>
            <begin position="37"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="NlpC/P60" evidence="5">
        <location>
            <begin position="231"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="207"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="56"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="151"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH84370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="346" mass="36375" checksum="28633551514DC029" modified="2015-07-22" version="1">MNARVASHRRTRARTAGAIVLVGTATATALGGFAHADPQPTPAGVRARVDRLHHEAERTVEEYNGVKEKADRTERTLDDLRDEAARKTARLNDARNALGSFATAQYRNGTADATVQLALSAAPEDYLRRAALLERVGNRQATALEGVGHRLREVEQVRAEARDRLAELKDARAELKRHKSAIEDKLTEARGLLDTLTADQRDAVLGADGHGGAAGDRAARGAPRGPVQAPNARAARAVSYAQGAVGSPYVWGAVGPAAFDCSGLTQAAWGAAGVSLPRTTYTQAAAGSTVPRSALAPGDLVFYYSGLSHVGIYAGGGQIIHAPRPGATVRYAPVDSMPFVTAVRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7B5</accession>
    <name>A0A0F7N7B5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptide methionine sulfoxide reductase MsrA</fullName>
            <shortName evidence="4">Protein-methionine-S-oxide reductase</shortName>
            <ecNumber evidence="4">1.8.4.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Peptide-methionine (S)-S-oxide reductase</fullName>
            <shortName evidence="4">Peptide Met(O) reductase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">msrA</name>
        <name evidence="6" type="ORF">AA958_22330</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>[thioredoxin]-disulfide + H2O + L-methionine = [thioredoxin]-dithiol + L-methionine (S)-S-oxide</text>
            <dbReference type="Rhea" id="RHEA:19993"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58772"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 4">
            <text>[thioredoxin]-disulfide + H2O + L-methionyl-[protein] = [thioredoxin]-dithiol + L-methionyl-(S)-S-oxide-[protein]</text>
            <dbReference type="Rhea" id="RHEA:14217"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12315"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:44120"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MsrA Met sulfoxide reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.11" evidence="4"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017741.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_22330"/>
    <dbReference type="EnsemblBacteria" id="AKH84480">
        <property type="protein sequence ID" value="AKH84480"/>
        <property type="gene ID" value="AA958_22330"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_22330"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4702"/>
    <dbReference type="OrthoDB" id="1554384at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033744">
        <property type="term" value="F:L-methionine:thioredoxin-disulfide S-oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008113">
        <property type="term" value="F:peptide-methionine (S)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01401">
        <property type="entry name" value="MsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002569">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036509">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01625">
        <property type="entry name" value="PMSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55068">
        <property type="entry name" value="SSF55068"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00401">
        <property type="entry name" value="msrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PMSR" evidence="5">
        <location>
            <begin position="50"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH84480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="230" mass="24961" checksum="8AA42E46EF5B039A" modified="2015-07-22" version="1">MFLNRHKNHLVTKDEAVPGRAAPAFPVPERHTVLGNPLEGPYPEGLEVADFGLGCFWGAERNFWQTPGVWTTLVGYQGGHTTHPTYEEVCSGRTGHTEAVRVVYDPAVVSYDELLKLFWESHDPTQGFRQGNDIGTQYRSAVYTHTPAQAKAADASRAAYQQVLSASGYGDITTEILPAADRPFYPAEPYHQQYLDKNPGGYCGIGGTGVKLSDQSEGGSCPTGIAPTES</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7B6</accession>
    <name>A0A0F7N7B6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cupin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_14830</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016598.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_14830"/>
    <dbReference type="EnsemblBacteria" id="AKH83283">
        <property type="protein sequence ID" value="AKH83283"/>
        <property type="gene ID" value="AA958_14830"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_14830"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3126"/>
    <dbReference type="OrthoDB" id="1928636at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016672">
        <property type="entry name" value="Polyketide_Synth_CurC_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016602">
        <property type="entry name" value="CurC_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="2">
        <location>
            <begin position="44"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH83283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="142" mass="15280" checksum="16C45B988D69A648" modified="2015-07-22" version="1">MAKNEAWTARVTLEDVAPNRRQGGAIRALLTPASVGATSGFLGHLELAPGEFVTEHYHPFSDKFLYVTEGSAVVRVDGEEVPLESDQALLITRGQRNRIENRGEGVLKAVFQIAPLAPRPELGHVDTEPVPHPGCVPPRVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7F0</accession>
    <name>A0A0F7N7F0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_15030</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_15030"/>
    <dbReference type="EnsemblBacteria" id="AKH83314">
        <property type="protein sequence ID" value="AKH83314"/>
        <property type="gene ID" value="AA958_15030"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_15030"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3167"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014322">
        <property type="entry name" value="RNA_pol_sigma-B/F/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
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</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-10-07" version="9" xmlns="http://uniprot.org/uniprot">
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        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
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                <person name="Kaysser L."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">CNQ-509</strain>
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    </dbReference>
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            <dbReference type="EMBL" id="AKH83971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="115" mass="12496" checksum="DA2805C994C92F79" modified="2015-07-22" version="1">MNGAIQEGSDAISDQPRQDHLIRDQQLRDSLYESMFTFTKGSTVLPKLFGGFQYSTAPSTSQAPLLNRAAAKAVLSDLPGDPVVLLLDTLVMVAQSHDGRHITWRELASVKLGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7H3</accession>
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        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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                <person name="Albersmeier A."/>
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                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </location>
    </feature>
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        <location>
            <begin position="20"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="83" mass="8814" checksum="58590944AC42672A" modified="2015-07-22" version="1">MPHSRYLFLTVACLTLSHAATSPTVSSRLATLWPNAADTVPALHRLRDTASEDADAEAQGNITAALATADAHAQVPEFREQTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7J5</accession>
    <name>A0A0F7N7J5_9ACTN</name>
    <protein>
        <recommendedName>
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        </recommendedName>
    </protein>
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    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
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        <subcellularLocation>
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            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
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        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.</text>
    </comment>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        </location>
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        </location>
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        <location>
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            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH84580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="248" mass="23601" checksum="AB76721B84E8AB1E" modified="2015-07-22" version="1">MTALILALAAGALIGVALGALGGGGSALAVPALIYLLGFGPVAATSAALVIVALTSATALAAHAREGHMRWRTGLLFAAAGAGPAMLGGALAGHVPGAVLTAAFAVVAGAAAVCMLRCRRRAEATPAVRPGRAAAAGAGLGGVTGFVGVGGGFLAVPALIGVLGMRMKAAVGTSLLVITVNALAALATRAGTVADLDWAVVGPFTGGAVLAAAGGKRLAARVSGDTLRGVFAVVLLAVAAFMLIDAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7S0</accession>
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        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="gene ID" value="AA958_15890"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_15890"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="124" mass="13285" checksum="AE9910253F2F2AF5" modified="2015-07-22" version="1">MKTFLIKTLANAAALAVAVWLIPDIGLTGHDNADKAVTLLLVALIFGVVNFIVKPLVQLLSLPLLVLTLGLFTLVINALMLMLTSWIADKADLSFHVDGFWTAVLGGLVISIVSWATSMALDRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8I6</accession>
    <name>A0A0F7N8I6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">AA958_17775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017051.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AKH83749">
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    </dbReference>
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        <location>
            <begin position="155"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="216" mass="22721" checksum="4A28DB95E08C63B1" modified="2015-07-22" version="1">MACDLWLVPLVDVLCHSPDNPFAEEIAAYDAALAQAGLPPVPVQSYMPGLSGDVAPVAGFDYDALHFLRRAYLLQLCGLEVTPVGELGGDYEQLLEMFESTAQQSHLVWHYDHAGAYVPVDFPHPLVTEELLAGGGPLGSAQGLVRELMAVAPAIGIDPDNPPPAPAPPPGPTELSEPAATAPADGGEFAQERHVWLGLHAAATRSLAQGSMIVFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8S9</accession>
    <name>A0A0F7N8S9_9ACTN</name>
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        <submittedName>
            <fullName evidence="9">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AA958_25060</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
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            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
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        <subcellularLocation>
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        </subcellularLocation>
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    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="entry name" value="DUF3817_TM"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03954">
        <property type="entry name" value="integ_memb_HG"/>
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    </dbReference>
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    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
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        <location>
            <begin position="6"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF12823"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AKH84935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="113" mass="12343" checksum="188522CA44CB4FC5" modified="2015-07-22" version="1">MKKSVLTRYRTMAYVTGVLLVLLTLGMIGKYALDLSGADGFTKVVSIAHGWLYILYLVFAFDLGSKAKLPVGRLIWVLLAGTVPTAAFFVERKLTRQVEPLVVREGEPAAAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N993</accession>
    <name>A0A0F7N993_9ACTN</name>
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        </submittedName>
    </protein>
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    </gene>
    <organism evidence="2 3">
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        <lineage>
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        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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                <person name="Leipoldt F."/>
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                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
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    </reference>
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    </dbReference>
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        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="138" mass="15625" checksum="09A711CBFE33F83C" modified="2015-07-22" version="1">MENILSVAIGAAIGLIGVLFGSWFTARRQDRMWLREQKLKAGIGFNTAVVQLLDYLKESQLSDDGPGANELANRMQEARSALYLLCAGDTVDLADALARRVWRTRPTDGRDDRRAEFRETLDLLRRFTRRLRQEIAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N996</accession>
    <name>A0A0F7N996_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribonuclease BN</fullName>
        </submittedName>
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    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
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    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
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        </subcellularLocation>
    </comment>
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    </dbReference>
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        <property type="entry name" value="Virul_fac_BrkB"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="yihY_not_rbn"/>
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    </dbReference>
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        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="3">
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            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH83312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="306" mass="32618" checksum="F4420DF6B8D60A39" modified="2015-07-22" version="1">MKRGVHARGRWANGARYRAALRRTPVALWNDDISDWAAALTYYAILTVLPTLFVTLTVIGLADPSGTEALIAYIAGLAPTGTDTALNDALHDVTRGHSTAWILTTVGTASAVWSACSFLSVFRRALHAMYGTSDSRPVLRRAPAILAMALLLLTLLVSGALTLVVTGPGMRALGRPLGMGEQTAALWDFLRWPFLVFVAALLVLLLFRSGPPESRNVSHAVPGGLLAGVLWLLASVGFAMYASYAAGTYSRLYGSLAGVVVFLIWLWFSNLALLAGAQFNALLARGEGNPEAARPPRRPAVPAVPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9F8</accession>
    <name>A0A0F7N9F8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Streptomyces</taxon>
        </lineage>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017926.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_23450"/>
    <dbReference type="EnsemblBacteria" id="AKH84671">
        <property type="protein sequence ID" value="AKH84671"/>
        <property type="gene ID" value="AA958_23450"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_23450"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4943"/>
    <dbReference type="OrthoDB" id="1721089at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519203" evidence="2">
        <location>
            <begin position="24"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH84671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="241" mass="25331" checksum="FB8DB248368B8078" modified="2015-07-22" version="1">MRKSVVAAALVSALGVTVLSACGSEDSGLAGKSPEEIKDETVAAMRSAKSMTLDFQQTGAAGTAMKLSVTKGGECTGSVTTQGATAEIRRAGGTSYMKPDTKFWEQNAGSPEQAQLIEATVGDRWVEMGAGQDDFASFCDLDTILKDMDDEDKGDGDKGGRKDTTEKGDEGEVRGTPTITLIAKEDGETTRVHIATEGEPYILKMEMEDGDQPGTAEFSEFNEKVDVTAPADAVNLNELGG</sequence>
</entry>
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    <accession>A0A0F7NA63</accession>
    <name>A0A0F7NA63_9ACTN</name>
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        <submittedName>
            <fullName evidence="2">4-carboxymuconolactone decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_21775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017650.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_21775"/>
    <dbReference type="EnsemblBacteria" id="AKH84388">
        <property type="protein sequence ID" value="AKH84388"/>
        <property type="gene ID" value="AA958_21775"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_21775"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4586"/>
    <dbReference type="OrthoDB" id="1893149at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004675">
        <property type="entry name" value="AhpD_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00778">
        <property type="entry name" value="ahpD_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMD" evidence="1">
        <location>
            <begin position="12"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="156" mass="17536" checksum="7F249A34EBD3A489" modified="2015-07-22" version="1">MTQRLDLFALAPDVHRALVRVEQAAKKGLDPVVCELVKLRASQINHCAYCIDMHTKDARAAGETEQRLYLLNAWEEVPHLYTEKERAALALAEAVTVLTDGFVPDEVYERAAKHFGEQELARLIGVLTVINAWNRWCVTSRAEAGDYRPGQYEQGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAG9</accession>
    <name>A0A0F7NAG9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Antitoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_22160</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Antitoxin component of a type II toxin-antitoxin (TA) system.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the phD/YefM antitoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017710.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_22160"/>
    <dbReference type="EnsemblBacteria" id="AKH84449">
        <property type="protein sequence ID" value="AKH84449"/>
        <property type="gene ID" value="AA958_22160"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_22160"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4667"/>
    <dbReference type="OrthoDB" id="2047723at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006442">
        <property type="entry name" value="Antitoxin_Phd/YefM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036165">
        <property type="entry name" value="YefM-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02604">
        <property type="entry name" value="PhdYeFM_antitox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143120">
        <property type="entry name" value="SSF143120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH84449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="91" mass="9924" checksum="64886AD57C65E494" modified="2015-07-22" version="1">MSISASEARKTLFPLIERVNDDHTPVRITSRSGDAVLMSADDFDAWQETIYLLRSPANARRLMEAVARDKAGSAAVSVSIDELENMAGGQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAH9</accession>
    <name>A0A0F7NAH9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_22440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH84498">
        <property type="protein sequence ID" value="AKH84498"/>
        <property type="gene ID" value="AA958_22440"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_22440"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519363" evidence="2">
        <location>
            <begin position="37"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH84498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="184" mass="18837" checksum="109276FC1414DBFB" modified="2015-07-22" version="1">MCAGWAMIARTFSSCPTCWRIVVASRSSSSRRRAAAKSGSRRPTQCASAGSPTPDTSIVDQSIGTPCDPSEPSTSSACPIRAAVSASRSRASVASGPPTAAQLGSSAPSVVQPARYGYVSRVTSTPSASARSSRAVSSAARPALTSKLRVACARCSAQPASLARPSISAYAPRAPAPYERWCGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAT3</accession>
    <name>A0A0F7NAT3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_23120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017870.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_23120"/>
    <dbReference type="EnsemblBacteria" id="AKH84613">
        <property type="protein sequence ID" value="AKH84613"/>
        <property type="gene ID" value="AA958_23120"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_23120"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4874"/>
    <dbReference type="OrthoDB" id="1582133at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="97"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH84613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="277" mass="31286" checksum="0D5F6CB89A44D2FE" modified="2015-07-22" version="1">MATGTTERPPSPDQPGGVRAPGRAAIAARHLRTDRWWLAPTATFTGLMAFIVYSTWRALSNADYYAAPYVSPFYSPCLGSDCVDMKNGPNFALFGDWWFMSPAAIILVFPLGFRFTCYYYRKSYYRSFWGSPPACAVAEPHKTYTGETRFPLIVQNLHRYFFYAAIAVAAILTWDAVLGFRNSEYEWGHVGLGTIVLWINVVLIWLYTLSCHSCRHIVGGRLRHFSKHPVRYRAWGLVGKLNERHALLAWASLISVGLADLYVYLLASGAFDDPVLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAX0</accession>
    <name>A0A0F7NAX0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase M16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_26865</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018493.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_26865"/>
    <dbReference type="EnsemblBacteria" id="AKH85256">
        <property type="protein sequence ID" value="AKH85256"/>
        <property type="gene ID" value="AA958_26865"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_26865"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5651"/>
    <dbReference type="OrthoDB" id="1188251at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="SSF63411"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M16" evidence="2">
        <location>
            <begin position="26"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M16_C" evidence="3">
        <location>
            <begin position="186"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="430"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH85256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="451" mass="48680" checksum="43E1A41600112A68" modified="2015-07-22" version="1">MGQTATPQANSGGLTLEEHRLDNGLRVILSEDHLTPVASVCIWYDVGSRHEVAGRTGLAHLFEHLMFQGSAQVSGNGHFELVQGAGGSLNGTTSFERTNYFETMPAHQLELALWLEADRMGSLLVALTQESLDNQRDVVKNERRQRYDNVPYGTAFEKLAAMTYPEGHPYHHTPIGSMADLDATSLADCQEFFRTYYAPGNAVLSVVGDIDPAQTLAWVEQYFGSIPAHDGKQPPRDGSLPDTLGGAQRVPLAEEVPSRALMASYRLPEDGTREADAADLALTVLGGGESSRLYNRLVRRDRLAVAAGFGMLRLAGAPSLGWLDVKASGGVEVPAIETAVDEELARFAEQGPTPEEMERAQAQLEREWLDRLATVGGRADEFCRYAVLFGDPKLALGAVERILGVTAEEVQAVAKARLIPENRAALVYEPTAPAADENAGAAGAEEDEVQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NB15</accession>
    <name>A0A0F7NB15_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polyketide cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_29555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018924.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_29555"/>
    <dbReference type="EnsemblBacteria" id="AKH85695">
        <property type="protein sequence ID" value="AKH85695"/>
        <property type="gene ID" value="AA958_29555"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_29555"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6237"/>
    <dbReference type="OrthoDB" id="1719670at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="167" mass="17972" checksum="1D9E6F2985B14CCE" modified="2015-07-22" version="1">MARRHRLIKVGPGRVWDVLGDGRRYAEWVVGTASSEPVRGRWPEVGAAIGYEVRLGPLRFANETVVRRRVEGSVLELEAHAGGLGTARIALEVHPWGENTLVTVDEHPLRGAAGALHNAGAEAVIQLRHRTMLARLARLCEAEAEPRTPAKSASGPARSGGGTQTRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NB50</accession>
    <name>A0A0F7NB50_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Beta-xylanase</fullName>
            <ecNumber evidence="6">3.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AA958_29840</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-xylosidic linkages in xylans.</text>
            <dbReference type="EC" id="3.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glycosyl hydrolase 10 (cellulase F) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.8" evidence="6"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018958.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_29840"/>
    <dbReference type="EnsemblBacteria" id="AKH85730">
        <property type="protein sequence ID" value="AKH85730"/>
        <property type="gene ID" value="AA958_29840"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_29840"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6302"/>
    <dbReference type="OrthoDB" id="654705at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031176">
        <property type="term" value="F:endo-1,4-beta-xylanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044846">
        <property type="entry name" value="GH10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031158">
        <property type="entry name" value="GH10_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001000">
        <property type="entry name" value="GH10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31490">
        <property type="entry name" value="PTHR31490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00331">
        <property type="entry name" value="Glyco_hydro_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00134">
        <property type="entry name" value="GLHYDRLASE10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00633">
        <property type="entry name" value="Glyco_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00591">
        <property type="entry name" value="GH10_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51760">
        <property type="entry name" value="GH10_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519267" description="Beta-xylanase" evidence="7">
        <location>
            <begin position="42"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="GH10" evidence="8">
        <location>
            <begin position="46"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH85730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="344" mass="37036" checksum="B38C62549CA884E0" modified="2015-07-22" version="1">MFSTSRRRRTRRRAWSAAAAAVTSAGLAAAGLLAFPGSAHAADTLGASAAESGRYYGAAVAPHLLGEANYAATLNREFNSIVAENVMKWDATEPRRGQFTFQGGDQLVAHAQSNGMSVRGHTLVWHAQQPSWVSGLTGGDLRQAMLDHIDGVAGHYAGKIDSWDVVNEAFEWDGSRRQSNLQQQIGNGWIEDAFRAADAADPGATLCYNDYGTDGVNAKSDAIYRMVQDFLARGVPIDCVGFQSHLDSNSNLGSYRQNLQRFADLGVDVQITELDIGGSGTAQANAYRTVTEACVAVSRCTGITTWGITDKYSWRGQDTPLLFDGNYQKKQAYNAVLEALNSAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBJ6</accession>
    <name>A0A0F7NBJ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_28535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018770.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_28535"/>
    <dbReference type="EnsemblBacteria" id="AKH85536">
        <property type="protein sequence ID" value="AKH85536"/>
        <property type="gene ID" value="AA958_28535"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_28535"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6012"/>
    <dbReference type="OrthoDB" id="1775418at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028978">
        <property type="entry name" value="Chorismate_lyase_/UTRA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011663">
        <property type="entry name" value="UTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07702">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00866">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64288">
        <property type="entry name" value="SSF64288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="5"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="248" mass="26819" checksum="43F82F357A9DBC05" modified="2015-07-22" version="1">MGDAKPVYQRIADDLRERIDGGELSVGAQIPSRSQLKRAYAASDQTVDRAVRVLKAAGYAHGQFGRGVFVADRTPVGSLLRSTGAVDSPFAARLVPEGVTLTWEAVSTPGPAPREAARRLGIPVGDRVMCTQYEYLADRKPVQLAVSWEPLAFTDGTDVVFPERGPYARRGVRGRFAAIGIRVVRAAELVGSRSATTAEAEALGCAPGQCVTTVERTHYDERGRAVETSEAVVRADRWRLEYDIAFTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBL8</accession>
    <name>A0A0F7NBL8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NADH dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_20110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NADH dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017397.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_20110"/>
    <dbReference type="EnsemblBacteria" id="AKH84107">
        <property type="protein sequence ID" value="AKH84107"/>
        <property type="gene ID" value="AA958_20110"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_20110"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4238"/>
    <dbReference type="OrthoDB" id="403436at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006116">
        <property type="term" value="P:NADH oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045024">
        <property type="entry name" value="NDH-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706">
        <property type="entry name" value="PTHR43706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="2">
        <location>
            <begin position="6"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH84107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="451" mass="48736" checksum="39A1A5E8EC806C70" modified="2015-07-22" version="1">MTNPTRVLVVGGGNVGMAVAMRLQKHLGKQLRSGAAQITLVAPDPYMTYQPFLAEAAAGSVQPRHVVVPLRRVLPRCRVVAGRVTSVDHSARTARVATLATDETGEPPLDLAYDQLVLVPGSVSRVLPVPGLAEYGIGFTSIEEAIGLRNHVLEQLDIASSTRDAAVREAALTFVFVGGGYAGVEALAELEDMARYATRYYTGVRPADMRWVLVEASDRILPEVGERLGEYAVRRLRERGIDVRLETRLSSCTDRVAQLDDGARFPTRTLVWTAGVRPNPVLAATGLPLNDRGRLRCTPDLRVEGEDAVWSAGDAAAVPDLTADEPGALCAPNAQHAVRQARVLADNLAAALRGTPLRDYRHRYAGSVASLGLHKGIAYVYGHRLKGYPAWLMHRAYHLGKLPTVGRKAHVLAEWTLAGLFKREIVALGSLEHPRAEFALATRSGRGPDGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBQ2</accession>
    <name>A0A0F7NBQ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sugar ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_31020</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019138.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_31020"/>
    <dbReference type="EnsemblBacteria" id="AKH85910">
        <property type="protein sequence ID" value="AKH85910"/>
        <property type="gene ID" value="AA958_31020"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_31020"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6556"/>
    <dbReference type="OrthoDB" id="1074175at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="140"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="72"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH85910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="279" mass="31086" checksum="67EEF157B9133B2E" modified="2015-07-22" version="1">MSHKLPRRARLVLYGVLLVLLVPFVFPTWWMVTSSLKPASEIFAFPPSLLPGDPGFGAYERVFDLQPFAQQYWNSMYIAVVVTIGTLAVSSMAGYAFARIRFRGQNALFLVVLTGLLIPSEVTIVPLFQMFNDWGLTDTHWPLVLVPILGAPSVLATFIMRQFFITLPAELEEAARMDGLGRFALYWRIALPLARPALAAVGIFTFLHSWNLYLEPIVYLSTPEKFTLPQALTQFTDAYGGPMWDVQLAAASLTALPVLAVFVFAQRQFVEGLAHTGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBS9</accession>
    <name>A0A0F7NBS9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AfsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_31165</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AfsR/DnrI/RedD regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019163.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_31165"/>
    <dbReference type="EnsemblBacteria" id="AKH85935">
        <property type="protein sequence ID" value="AKH85935"/>
        <property type="gene ID" value="AA958_31165"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_31165"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6585"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15831">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03704">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="262"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH85935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="1065" mass="115288" checksum="F2555317DF96ED4D" modified="2015-07-22" version="1">MVERRVELRALGPLELWQGEQRRDLGSVKERCVLAVLVHARGRSVTAEALTERVWDGSPPPSAQGTLHSLLSRLRSRLKPYRDAIELERPSPGVYRLRVRPGSVDLLRFEELRTQTATAVAQGERRRAVGLLRTAESLWRGEPLAEFPGTWATATRARLLEDLRRVREQRIRLELEAGRHSDLIGELRELVAENPLAQRLVASLMLALYRCGRHAEALDLYRTTHRRLDEEQGMAPAAELRELHRRILEQDRELLAAPTPAAGTPVDAAVTPAPRTNLPRDTHDFTGRTSELSLLLTDARTGSGARAADGGREKRALPLTVIEGMPGVGKTSLAVHVAYGLGHAYPDGQLFLDLRGFSGQQPYGPAEALAVLLQTCGAPKLPDTLDERASAWREWTARRRLLLVLDNARDAAQVEPLLPASPACRAIVTSRNRLRLDGAEELHLEVPSAAEAAELFTRVVGAARLPGDGATLAGVVSACGCNPLALRLLAGRFRHRGSWDLPHLLDRLSQAADPLDELDPAVAAAFRLSYEELNAPAREMLCALALAPGPDLPPTAVLALVGAAPDVPPAGPRRSIDELQDCNLLDEPVRDRYRLHDLTRAFGLQAGQHDLQPAARQAAFDRLAAHYLTAAHRATRLAHPHHRILPLPPGLVSPYAPQFADADVASVWLSVERANLLATATHAATASPATAALFPHVLAPSLERWGAREPAAALYDAALAVLRTHGDTAALARTLVDRAARLAKENPEGALRNAREALAEFRRGGDALGCADALLQVARAHVTAGDSEATLRVLNEALSLYAKDGDRHGEAQCLNVRGLALRYAGRHREAVETAHATLALRREIGDLYGEAMALNNMGELRRGEGDYDAARACYEQSLALMRRCGERGDLAILSTNLGIVHHATGHTTEALASFHQALQSHRAAGDALGEVHALTSLGNLYAECGRRSEAVLHFGMAARLAATIGNAYERQRALVGMADVHRRSGKLTAARETYELGHRIADEAGIPLGSAHALEGLARVALAASDAGEMRRCAELAMALYRAREADSDADRVARLLREHGMTGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBX8</accession>
    <name>A0A0F7NBX8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thioredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_25075</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_25075"/>
    <dbReference type="EnsemblBacteria" id="AKH84938">
        <property type="protein sequence ID" value="AKH84938"/>
        <property type="gene ID" value="AA958_25075"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_25075"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5284"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="28"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH84938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="320" mass="33431" checksum="F13A7D61C740869D" modified="2015-07-22" version="1">MSGAVDLAAVKAAAEAKEKAEAARAQAARDGVPAPGAGALVIDVDEAGFQQDVLQRSTEVPVVVDFWAEWCQPCKQLSPLLERLAQEYAGRFVLAKIDVDANQMLFQQFGVQSIPAVFAVVGGQAIPLFQGAAPEPQIRGVLDELIKVAEQQFGIVGQAVAGEDAAAGEEAGEREAPEEPAGPYDSALAAAGDALDRGDLGGAIQAYQNVLSDDPGNVEAKLGLAQAELLRRVEGLDPAAVRKEAADNPADVAAQIRVADLDLVGGHVEDAFGRLVDTVARTAGEDRQAARVRLLELFEVVGGDDPRVVAGRQALARVLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NC10</accession>
    <name>A0A0F7NC10_9ACTN</name>
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        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
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    <gene>
        <name evidence="7" type="ORF">AA958_20865</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP011492">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH84237">
        <property type="protein sequence ID" value="AKH84237"/>
        <property type="gene ID" value="AA958_20865"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_20865"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4398"/>
    <dbReference type="OrthoDB" id="1384345at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF07690">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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            <begin position="21"/>
            <end position="45"/>
        </location>
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            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
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            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
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            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
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            <end position="273"/>
        </location>
    </feature>
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            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
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            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="348"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
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            <begin position="377"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="23"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH84237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="399" mass="39290" checksum="1A073F175657A207" modified="2015-07-22" version="1">MSDIPVNRPAEPAGAAQARGLSATLVLALGTFAVGTDAFVVAGFLPAMAGSLDVSESAAGQSVTVFAAAYAALSPVLATACARVPRRTLLVGALLVLAAANLGSALAPDLPVLMASRVLAAAGAAAFTPGAGAVAAALAPPERRARALAVVIGGLTMATALGVPLGTLAERAVDWRTALGLVAALCACCALGVYAVMPPLPGGAPVPLRARLRALRRPGVLAVLPLTALGMGAGYTVYAYTVPVLADVGVDASGAVWMLCLYGTGAVAGNFAAGLATDRWGAVRVLAFGYALMATGLGVLALSAAAGLRFLPLTAAAMVAWGASSWCQTPPQQHRLISAAPQETALVVGLNASAIYTGIGLGTLLGGALLPLGTAEAATAGAVLAVAAGAWLAGTRRYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NC12</accession>
    <name>A0A0F7NC12_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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    </dbReference>
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH84242">
        <property type="protein sequence ID" value="AKH84242"/>
        <property type="gene ID" value="AA958_20895"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_20895"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4404"/>
    <dbReference type="OrthoDB" id="1804797at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016888">
        <property type="entry name" value="UCP028498"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10012">
        <property type="entry name" value="DUF2255"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH84242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="126" mass="13801" checksum="BD995EF71C84CCCA" modified="2015-07-22" version="1">MAGWTDDELERIGSAEELNLQSLRGDGTLRDPVTMWVVRDGDDVYVRSVKGAQGPWFRGTRSRLEGRIRAGGVDKDVAFVDVGDGGETTSRLDAAYRAKYGRYPADIFGSIVTPQAQAATLRLVPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-10-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NC18</accession>
    <name>A0A0F7NC18_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Lysine transporter LysE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_25310</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018230.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH84979">
        <property type="protein sequence ID" value="AKH84979"/>
        <property type="gene ID" value="AA958_25310"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_25310"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5334"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="LeuE-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30086">
        <property type="entry name" value="PTHR30086"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LysE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006324">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="41"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="151"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH84979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="214" mass="22531" checksum="0FF42BA9F58D4D9A" modified="2015-07-22" version="1">MVDLSLLAAFVVAIFVLSITPGPDMMFIVAMGGRGGSGMGVMAAAGVACGMLVHACAAALGLSALFGALPVLYHVLRWLGAAYLLYLAIRAFRDRSVPGDEDDAAADGRRGGPRPRRAFWQGMITNLLNPKVIMFNIAFLPQFVDPGRGHLPLQLLLLGITGVVVGFCVDGSVGLLSGRLSRALRRSRRLARGLNIFSGTVFAGLAVRLAATPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCI7</accession>
    <name>A0A0F7NCI7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Methylmalonyl-CoA mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_21970</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterodimer of an alpha and a beta chain.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="AA958_21970"/>
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    <dbReference type="KEGG" id="strc:AA958_21970"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004494">
        <property type="term" value="F:methylmalonyl-CoA mutase activity"/>
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        <property type="entry name" value="MeMalonylCoA_mutase_a/b_cat"/>
    </dbReference>
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        <property type="entry name" value="MMCoA_mutase_a_cat"/>
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        <property type="entry name" value="SSF51703"/>
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        <property type="entry name" value="acid_CoA_mut_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="6"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH84417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="526" mass="57390" checksum="8AF0FB1B84A36D13" modified="2015-07-22" version="1">MVRHSESGLPIEPVYGPGALAGWHPDVRLGEPGAYPYTRGVYPTMYTGRPWTMRQYAGFGTAAESNARYRDLIAHGTTGLSVAFDLPTQMGHDSDAVLAHGEVGKVGVAIDSLDDMRVLFDGIPLDRVSTSMTINAPAALLLLLYQLVAEEQGVDAAQLTGTIQNDVLKEYIARGTYIFPPKPSLRLIADIFRYCRAEIPKWNTISISGYHMAEAGASPAQEVAFTLADGIEYVRTAVAAGMHVDDFAPRLSFFFVSRTTILEEVAKFRAARRIWARVMREEFGARNPKSQMLRFHTQTAGVQLTAQQPEVNLARVTVQALAAVLGGTQSLHTNSFDEAIALPTDKAARLALRTQQVLAYETDMTATVDPFAGSYVVETMTDDLEEAAVDLMRRVEDQGGAVSAIENGFQKGEIERSAYRIAQETEAGERVVVGVNRYQLAEEEPYEPLRVDPAIEARQVERLARLRDARDGGAVAAALAELRTAAEGTGNVLYPMKTALAARATVGEVCEALREVWGTYEPVNAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCL6</accession>
    <name>A0A0F7NCL6_9ACTN</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_32945</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86230">
        <property type="protein sequence ID" value="AKH86230"/>
        <property type="gene ID" value="AA958_32945"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_32945"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6961"/>
    <dbReference type="OrthoDB" id="2062825at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH86230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="64" mass="6601" checksum="41F9683D9EF5A14A" modified="2015-07-22" version="1">MSAQTTPGLFPVRAGVAERAALTALVDEPEAPFSDAPVYTPQGAGVLLLLALLSPRAPKESRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCX1</accession>
    <name>A0A0F7NCX1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_33505</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AKH86330">
        <property type="protein sequence ID" value="AKH86330"/>
        <property type="gene ID" value="AA958_33505"/>
    </dbReference>
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    <dbReference type="PATRIC" id="fig|444103.5.peg.7076"/>
    <dbReference type="OrthoDB" id="1638924at2"/>
    <dbReference type="Proteomes" id="UP000034283">
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    </dbReference>
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        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
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        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00670">
        <property type="entry name" value="D_2_HYDROXYACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2-Hacid_dh" evidence="3">
        <location>
            <begin position="33"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="2-Hacid_dh_C" evidence="4">
        <location>
            <begin position="125"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH86330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="341" mass="36364" checksum="8258EA41B25406A3" modified="2015-07-22" version="1">MTGSADRGAGRDRVVVCVPPELRAQFFTDAVWRRLADAAELTVLDEHRDRAALAAALPGARALVTAWGAPRLDAGLLAVADRLELLAHTGSAVAPYVTEDAFLRGVRVTQAGDAMARPVAEVALAFSLALLHRIHRFDHAMRRGDHWESAGQAPPRHELGASAVGVIGASRTGRAYIELVRAFGARVSVTDPFLSEADAAELGVRLLPLDELLRTSRIVAVHAPATEATRRMLGAPQLALLPDGAGLVNTARSWLVDEDALLAEVRDGRIDAALDVFDAEPLPAGHPFRQLPNVLLTPHQAAGTAECRERLGESAVTEVLRLLAGEEPLHAVDATALTRLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCZ4</accession>
    <name>A0A0F7NCZ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_26820</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018485.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_26820"/>
    <dbReference type="EnsemblBacteria" id="AKH85248">
        <property type="protein sequence ID" value="AKH85248"/>
        <property type="gene ID" value="AA958_26820"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_26820"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5642"/>
    <dbReference type="OrthoDB" id="1688736at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="289"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="94"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH85248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="316" mass="34929" checksum="038CB44D3AAD6294" modified="2015-07-22" version="1">MAAPTLSRRAAPAGGRPAGRRRTGREDFGRALRRNLTAHGFLIGAVLCFTLFSWYPMVREFILAFQKNEDGETVWAGWSNLSYIVNDPAFWQAWRNTFAFTGLALLLGFAVPFAVAIVLNEFRHGRAYLRILVYLPVMLPPVASVLLFKYFYDPGHGLFNRILETFGLPAQDWLQSGDTAMVSVVIAATWMNMGAATLIYLAALQGIPGELYEAAELDGAGLFRKIWHVTIPQTRLILSLMLLMQIIATMQVFVEPFLLTGGAGPENSTLTVVQLIYQYAFTFNNYGSAAALGVVLMLVLAVFSAAFVRLDRGSED</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7ND74</accession>
    <name>A0A0F7ND74_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_32625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019408.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86181">
        <property type="protein sequence ID" value="AKH86181"/>
        <property type="gene ID" value="AA958_32625"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_32625"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6891"/>
    <dbReference type="OrthoDB" id="391678at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011518">
        <property type="entry name" value="Transposase_36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027805">
        <property type="entry name" value="Transposase_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07592">
        <property type="entry name" value="DDE_Tnp_ISAZ013"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13613">
        <property type="entry name" value="HTH_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_Tnp_4" evidence="1">
        <location>
            <begin position="621"/>
            <end position="665"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="697" mass="77332" checksum="5DA15E556F30AE7B" modified="2015-07-22" version="1">MGVSEVVRGQLVQRFEALLPHLNERQRRLAVATEARLLGHGGVRCAARTAQVSETTVRKGIAELAVAEPLPEGRVRRLGGGRRRAEDLDPQLVPSLMALVEPDERGDPVSPLRWTTKSLRHLAAELSRQGHRVTAPTVGRLLKENGFSLQGTAKILEGEQHPDRDAQFRHINEQVKDHQAASEPVISVDAKKKEQIGLLPMAGREWRPGKQPLAVEDHSFFAGPHVDAVIPYGIYDMTANTGWVNVGTDHNTAVFAASSIRRWWHERGRHDYPQASRLLITADAGGSNSYRYRVWKAELAAFAAESGLTVTVCHFPPGTSKWNKIEHRLFSHITLNWRGRPLTSHDVVLNTIAATTTRTGLRVEAMLDTGSYPTGISITRDQLKALPITPHDRHGRWNYSIAPTGAAAPVPGADDSAAARRQTLTMLADPRLTGMTAGELRELHARLAPAQAARAEQHRYVLRGGRRVATTGRSRALLGDQDEVLITVLYLRQVCPQKVLCDLLGINPVTIGQAIKATRQLLDELKITITPTVVRYFTRAQDLRDWLDGVTDVPATMTSPQQQALTDPHLTGLEREALHQLLEELIVPYAAAIERRRHRQRGGNRRPGTRGGVFRQKITDGDRILATLLHRRRVCTLDALAELFGVSRSTLWNAIRDVQPILDDRRIDIATSPHRYITAREALDAVRDGTDNHQVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDA0</accession>
    <name>A0A0F7NDA0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Urease accessory protein UreD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ureD</name>
        <name evidence="4" type="ORF">AA958_00335</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the UreD family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_00335"/>
    <dbReference type="EnsemblBacteria" id="AKH86460">
        <property type="protein sequence ID" value="AKH86460"/>
        <property type="gene ID" value="AA958_00335"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_00335"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.79"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01384">
        <property type="entry name" value="UreD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002669">
        <property type="entry name" value="UreD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01774">
        <property type="entry name" value="UreD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0996">Nickel insertion</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH86460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="258" mass="26487" checksum="83C953E9C7E75812" modified="2015-07-22" version="1">MPAGEVRARARITAAPDGRGGTALPELAGDGPLALRRIRAGAGEARVCLVGAMAGPLGGDRLGLDVRVEAGAALSVTSAAATLAMPGTAGETARYDVRLTVGDGAVLRWLPEPMVSVRGSRLHVTYRVDLAPTTRLVFREEQVLGRAGEPPGRLVSRLTVRSGGRPLLDQTTDYGPGAPAWDGPAVLADNLAAGQLLTVAPEFHDAPAGPCVLAPGRAVLTPLPGPGTLATAVAPDAQILRTLLDDAQARATYRGRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDG5</accession>
    <name>A0A0F7NDG5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Crystallin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_33255</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019511.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_33255"/>
    <dbReference type="EnsemblBacteria" id="AKH86286">
        <property type="protein sequence ID" value="AKH86286"/>
        <property type="gene ID" value="AA958_33255"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_33255"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.7024"/>
    <dbReference type="OrthoDB" id="1661477at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4080.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005502">
        <property type="entry name" value="Ribosyl_crysJ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036705">
        <property type="entry name" value="Ribosyl_crysJ1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03747">
        <property type="entry name" value="ADP_ribosyl_GH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101478">
        <property type="entry name" value="SSF101478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH86286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="364" mass="37171" checksum="04E2E43E54B93D11" modified="2015-07-22" version="1">MSAAAGPEPPVRPEPSVTVRLRPVARGAGQAAPTARDRARGAMLGLAVGDALGAPVENMKPSQIRERWGRIEDFVAAAPAGTDDTEYAIFSGLLLAEHGARLSLAHVESAWHERIADLDEGPFRGAGFSERGTLENLRRGLAAPITAQHRHAWSDGLAMRAAPFGVFAAGRPAEAARLVAIDGTVSHEGEGIYGGQAVAAGVAAAMAGDSPDVVVQAALSVIPEDSWTSRSLQRAVSAGRRARHAPGATPLSVERAVRSSVVIGGYPWSDLAPEAVGLALGAFTAARGDFAGSVLTAVNMGRDADTTAAVAGALAGALRGESAIPGAWAAAIKPVRGTCLPSMAGHHVLDIADRLAPADEEVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDP4</accession>
    <name>A0A0F7NDP4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">OHCU decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_28415</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018747.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_28415"/>
    <dbReference type="EnsemblBacteria" id="AKH85513">
        <property type="protein sequence ID" value="AKH85513"/>
        <property type="gene ID" value="AA958_28415"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_28415"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5988"/>
    <dbReference type="OrthoDB" id="1777613at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018020">
        <property type="entry name" value="OHCU_decarboxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017595">
        <property type="entry name" value="OHCU_decarboxylase-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036778">
        <property type="entry name" value="OHCU_decarboxylase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09349">
        <property type="entry name" value="OHCU_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158694">
        <property type="entry name" value="SSF158694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03180">
        <property type="entry name" value="UraD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OHCU_decarbox" evidence="2">
        <location>
            <begin position="13"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH85513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="170" mass="17969" checksum="8E0B75C0CE3A5B2D" modified="2015-07-22" version="1">MTSRVPPGLARLNSADDQAVAALLHEVCAAGPWIAAVAAGRPYPEPAHLYAAAEAALAALDETGLAEAMAGHPPIGRPAPGDPASAREQRGMAGAPEELRAELRELNLAYQERFGHVFLICATGLGAVRMRDALRARLGNAPEREREIARGELGKINRIRLTRLVEAEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDS6</accession>
    <name>A0A0F7NDS6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_10240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019928.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_10240"/>
    <dbReference type="EnsemblBacteria" id="AKH86660">
        <property type="protein sequence ID" value="AKH86660"/>
        <property type="gene ID" value="AA958_10240"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_10240"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2158"/>
    <dbReference type="OrthoDB" id="1339160at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="50"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="152"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH86660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="389" mass="43304" checksum="0575398533ACE646" modified="2015-07-22" version="1">MPRRTLRIAMNGVTGRMGYRQHLVRSILAIREEGGLDLGGGDVLWPEPVLVGRREHALEDIARRHDLPEYTTDLDAVLADDSVELYFDAQVTSAREEAVKKAVAAGKHIYVEKPTATSASAALELARMAQDAGIKHGVVQDKLFLPGLLKLKRLIDGGFFGRILSVRGEFGYWVFEGDWQPAQRPSWNYRAQDGGGMVLDMFPHWEYILHELFGPVRSVQAHVTTHVPRRWDEHGEAYDATADDAAYGIFELAAPGGPVVAQINSSWTVRVHRDELVEFQVDGTEGSAVAGLRGCRVQHRAATPKPVWNPDLPVSESFRDQWQDVPDNAGPVGFANGFRAQWELFLRHLMRDEPYHWDLLAGARGVQLAELGLKAAAEGRRVEVPELAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NE00</accession>
    <name>A0A0F7NE00_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">ATP synthase subunit a</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">ATP synthase F0 sector subunit a</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">F-ATPase subunit 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">atpB</name>
        <name evidence="13" type="ORF">AA958_24845</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11 12">Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11 12">Cell membrane</location>
            <topology evidence="11 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11 12">Belongs to the ATPase A chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018149.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_24845"/>
    <dbReference type="EnsemblBacteria" id="AKH84897">
        <property type="protein sequence ID" value="AKH84897"/>
        <property type="gene ID" value="AA958_24845"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_24845"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5238"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045263">
        <property type="term" value="C:proton-transporting ATP synthase complex, coupling factor F(o)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01393">
        <property type="entry name" value="ATP_synth_a_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000568">
        <property type="entry name" value="ATP_synth_F0_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023011">
        <property type="entry name" value="ATP_synth_F0_asu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045083">
        <property type="entry name" value="ATP_synth_F0_asu_bact/mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035908">
        <property type="entry name" value="F0_ATP_A_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11410">
        <property type="entry name" value="PTHR11410"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00119">
        <property type="entry name" value="ATP-synt_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00123">
        <property type="entry name" value="ATPASEA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81336">
        <property type="entry name" value="SSF81336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01131">
        <property type="entry name" value="ATP_synt_6_or_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00449">
        <property type="entry name" value="ATPASE_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 11 12" id="KW-0138">CF(0)</keyword>
    <keyword evidence="6 11 12" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8 11 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AKH84897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="272" mass="30273" checksum="D5C485EB9C4D93F8" modified="2015-07-22" version="1">MSAADTTLAFDASCKIFVEGGCGFQSPGLHSFVFKPMFTIGSFEFNKPILLALVTTLVLCVFFWKAFASPKVVPGKLQMVAESGYDFVRRGIAYETIGKKEGEKWVPLLVSLFFFIWLMNLWSIVPLAQFPVTSIIAFPAALAGVVYVTWMTLTFKRHGFVGGFKNLTGYDKSLGGVLPLVMLIEFFSNVLVRPFTHAVRLFANMFAGHLLLVMFTIATWFFMNSWGFAYAPVAFVMVMVMIAFELFIQAVQAYVFVVLTASYISGALEEAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NEG0</accession>
    <name>A0A0F7NEG0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_10405</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019934.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86666">
        <property type="protein sequence ID" value="AKH86666"/>
        <property type="gene ID" value="AA958_10405"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_10405"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2191"/>
    <dbReference type="OrthoDB" id="1459004at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="226"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH86666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="405" mass="43516" checksum="1214EF12955F2560" modified="2015-07-22" version="1">MRGEAPRPPRRRREVVAVLLFSGGPVFENSIPLSVFGVDRQDAGTPRYRLLVCAGEDGPLRTTGGLELSAPYGLEALARAGTVVVPAWRSITQPPPAAALDALRRAHEDGARIVGLCTGAFALAAAGLLDGRPATTHWMYAPTLAKRYPSVHMDPRELFVDDGDILTSASTAAGIDLCLHLVRQDHGAEAAAALSRRLVVPARRGSGQERYLDRSLPEEIGGDPLAEVVAWALENLHEQFDVETLAARAYMSRRTFDRRFRSLTGSAPLQWLITQRVLQAQRLLETSDFSVDEVAGRCGFRSPVALRGHFRRQLGSSPAAYRAAYRARNPQSVPPPEPPTVPAPRRPQPPGAAGPAGVAGGGADGAEKPQSDAFAPGHTEPHPPRHRGALVRRATVPGQRDRHVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NEX6</accession>
    <name>A0A0F7NEX6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Tylosin resistance protein TlrC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_30945</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019126.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_30945"/>
    <dbReference type="EnsemblBacteria" id="AKH85898">
        <property type="protein sequence ID" value="AKH85898"/>
        <property type="gene ID" value="AA958_30945"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_30945"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6540"/>
    <dbReference type="OrthoDB" id="1112046at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="6"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="374"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="344"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="251"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="407"/>
            <end position="414"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH85898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="568" mass="60609" checksum="D1B4C5444A03F7B8" modified="2015-07-22" version="1">MTTAQLSLHTVTKRYGERVVLGDVTLTVRPGEKAGVIGDNGSGKSTLLRLLAGRTRPDTGEATLVTPGGLGYLPQSLDLPQEATVQDAVDTALAGLRALEAELRRAESGLAGAAPGALLDAALAAYGRLVEEYETRDGYRADTRVDAALTGLGLPALARDRRLGTLSGGERSRLALAATLAARPEVLLLDEPTNDLDDRAVAWLEDHLRAHRGTLVAVTHDRLFLERLTTTVLEVDGGRVTRYGDGYDGYLAAKAAERARMLREYEEWRAELARNRRLAESAATRLTAIPRSQPLAVFGHGAFRTRSRTHGAAVRIRNAKERVARLTSNPVRPPPQPLVFRARLESGGPGAAPPGGSAAVADAGGTPAGPEPAAEVPAAELADVVVGDRLRLPSLRLGAAERLLVTGPNGAGKTTLLRVLAGELRPDSGTVRVPGSVGHLRQGETAWPPGATVLRAFAADRPGTPDEHAERLLSYGLFRPADLRLRVGELSYGQRRRIDLARLIAEPVDLLLLDEPTNHLSPALVEELEQALAGYAGALVVVTHDRRMRARFTGNRLHLDAGTPRPQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NEY6</accession>
    <name>A0A0F7NEY6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_31655</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019247.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_31655"/>
    <dbReference type="EnsemblBacteria" id="AKH86019">
        <property type="protein sequence ID" value="AKH86019"/>
        <property type="gene ID" value="AA958_31655"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_31655"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6685"/>
    <dbReference type="OrthoDB" id="15684at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010496">
        <property type="entry name" value="3-keto-disaccharide_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005084">
        <property type="entry name" value="CMB_fam6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037524">
        <property type="entry name" value="PA14/GLEYA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011658">
        <property type="entry name" value="PA14_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011041">
        <property type="entry name" value="Quinoprot_gluc/sorb_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16990">
        <property type="entry name" value="CBM_35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06439">
        <property type="entry name" value="DUF1080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07691">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00758">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50952">
        <property type="entry name" value="SSF50952"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51175">
        <property type="entry name" value="CBM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51820">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519383" evidence="2">
        <location>
            <begin position="29"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="domain" description="PA14" evidence="4">
        <location>
            <begin position="55"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="CBM6" evidence="3">
        <location>
            <begin position="689"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH86019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="1012" mass="110068" checksum="C6D1EF11FBE883D6" modified="2015-07-22" version="1">MSARLYHRVRRRMTTVLAAAFLVGGVWAAPAGADPAPDPDRAPGPQNQPFAELPPQEPGVTLRTYDVQVPLEEICTLKPAQTPNVDKLMPQIDFSTAGDFGFEDNFVSHTTANINVPQDGTYTFRLTSDDGSRLLIDNQVVIDHDGLHGTDPPKDGTVELTAGYHSLFIEHFERGGGQQVTLAWQPPGASGFATVPNSVLSTDAGVVRVTAPGRKECEGYTDSPGDGLPLNSVHPDFTLTDLRPDGFEPQVTAMDWLPDDRLAVTTWGGTDNVTGEVYLLDNVTGDTSPEKVTVKKVAEGLKEPQGIKYVEGDLYVSQKHELTRLKDEDGDEVTDAYETVATWPFSDNFHEFAFGLLYKDGFFYLNLSVAINYGGATTDPQPSENRGTTIKVNRKTGQISYVAGGLRTPNGIGWGPKDDLFVLDNQGGWLPSSKLLHVKQDRFFNHYTNPDGPFDDKPVTQPVLWLPQNEIANSPSTPLYMDKGTFAGQLLFGDVTYGGIQRADLQKVEGEYQGAVFRMTQGLEAGVNRISMGPDGAIYAGGLGAGGNWGQPGKLKHGLQKLTPGGNEAFDIVSMDATETGFEMSYTKPLSQETADALAESYSVTQWRYVPTPEYGGPKVDEEVLPVTSAKLSDDRKKVTLEIPGLKPGHVVHVRSPRPFTAEGGQELWSTEAWYTLNNIPGDEDRVPTAYEAEEARLEGGANLADDHAGHSGRGFVAGYGTKGASTTFDVTTEKGGTYDVGLRYSNGPNPFTGTKTVSMYVNGTKVKQAQLASTGTWQEWTTRTEKVSLRAGGNTIRYVNEGDDTGHVNLDMISVHRSGEPVTLFDGADRSAFQHVDGRTPEWPLLDGEAMEVCCGDIRTKKAYEDFKLHVEFWLPELPPDVTGQDRANSGVYLQERYEVQILDSYGKDPLANDDAAAIYKKKAADVNAAKPPGTWQTYDITFRAARFDADGKKTEDARISVVWNGVKVQDDVAVDGPTGAGKPETPVAGAIRLQDHGNAVRYRNITVQPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NF41</accession>
    <name>A0A0F7NF41_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_31240</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019176.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_31240"/>
    <dbReference type="EnsemblBacteria" id="AKH85948">
        <property type="protein sequence ID" value="AKH85948"/>
        <property type="gene ID" value="AA958_31240"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_31240"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6601"/>
    <dbReference type="OrthoDB" id="916788at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="199"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="81"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH85948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="281" mass="30962" checksum="7965B3A7CB900A77" modified="2015-07-22" version="1">MVLAQDDVKKPAGRRPGGGSGGGAVRAWIRRVWPSLAVFVAAFLLWELAVELFGISSFELAKPSEFLAEMWRSRDMLGDAAWVTTQEILYGFLLSFAIGVLLAVLIVRFGWLERALYPLIVLFQVVPKVALAPIFILWFGYGLAPKLLLIVVITFFPITLNTIVGLKAIDQDLLLLMRSVGSSRNQILTRIQIPTSLPYLFAGMRIAITLAVIGAVVAEFSGAQNGLGYLIQFASTQLDTPLMFAALTLVSLLGLILYYGMSLLEFLLRKRFPHITADTTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NF91</accession>
    <name>A0A0F7NF91_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase M22</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_21430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020292.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_21430"/>
    <dbReference type="EnsemblBacteria" id="AKH86941">
        <property type="protein sequence ID" value="AKH86941"/>
        <property type="gene ID" value="AA958_21430"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_21430"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4512"/>
    <dbReference type="OrthoDB" id="1826274at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022496">
        <property type="entry name" value="T6A_TsaB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="PTHR11735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF11">
        <property type="entry name" value="PTHR11735:SF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03725">
        <property type="entry name" value="T6A_YeaZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TsaD" evidence="1">
        <location>
            <begin position="30"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="221" mass="22525" checksum="B6E4B3EBFDFB34DC" modified="2015-07-22" version="1">MDTASPAVTVALHDGDPASPALAASHQVDARRHGELLLPAVDRVLAEAGRGLGELAGVVVGVGPGPYTGLRVGLVTAEVLGMTLGIPVYGVCTLDGIAYAAGRDGAGGIDGPFVVATDARRKEVYWARYADARTRVTDPAVDRPADLAGQVAGLPAAGAGAELYPEAFPDARPPAHPHAAALAALAAERLAAGTELLPPRPLYLRRPDAQVPAAYKAVTPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFA7</accession>
    <name>A0A0F7NFA7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Metallophosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_27615</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018611.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_27615"/>
    <dbReference type="EnsemblBacteria" id="AKH85377">
        <property type="protein sequence ID" value="AKH85377"/>
        <property type="gene ID" value="AA958_27615"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_27615"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5819"/>
    <dbReference type="OrthoDB" id="165142at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd07389">
        <property type="entry name" value="MPP_PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018946">
        <property type="entry name" value="PhoD-like_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038607">
        <property type="entry name" value="PhoD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032093">
        <property type="entry name" value="PhoD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09423">
        <property type="entry name" value="PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16655">
        <property type="entry name" value="PhoD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519592" evidence="2">
        <location>
            <begin position="34"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="PhoD_N" evidence="4">
        <location>
            <begin position="51"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="PhoD" evidence="3">
        <location>
            <begin position="157"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="498"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="498"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH85377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="521" mass="57184" checksum="2FD2EA250CDBD556" modified="2015-07-22" version="1">MTVDRRTLLKSAAAAGALGAAWPLTAGLSPAQARAAAERLGAAYDTAPFTLGVASGDPQPDSVLLWTRLAPEPLAAEQDLPDIVEVRWALAEDPGLRRVVARGTTPASATLGHSVHVPVTGLTPGRTYHYAFSALGRTSRTGRTRTAPGGTVGRVRFAAANCQAFHDGYYAAHRGIAAENVDFVLHLGDYIYEHGQVGGVPEDHVRDHDGPEILTLADYRKRHALYKGDPALRDAHAAHPWFLTWDDHEVVNDYSGSTGGAPFVRRRAAAYQAWYEHMPHRDSFGDSALPDPEIHRTRDWGGLVQLAILDLRSHRSAQNLPDGTILGTDQKNWLKHHIDNAPDTWHVWANSIMLSQLRGSPGGPYMFTDQWDGFLAERKEILQHVHAAGLEDLVVVTGDWHSAFVDDIRTDYDDPESPLVGTEFTAHSVTSGAYSPDWNRTNGPVMGAANPHLKYFEGNRYGYDVYDVTPGRFSAHMRVIGDRRDPDSPVTTLTTFHVDRGSTGSYEDQATKNSPAQYRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFC0</accession>
    <name>A0A0F7NFC0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Acetate permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_31780</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019266.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_31780"/>
    <dbReference type="EnsemblBacteria" id="AKH86038">
        <property type="protein sequence ID" value="AKH86038"/>
        <property type="gene ID" value="AA958_31780"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_31780"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6711"/>
    <dbReference type="OrthoDB" id="278483at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00813">
        <property type="entry name" value="sss"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="138"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="261"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="295"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="353"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="402"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="428"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="461"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="502"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH86038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="546" mass="56602" checksum="6207FC767AD33F1F" modified="2015-07-22" version="1">MTGATTNALQMVAQSDPGEHRTLIVTLFSVFVALTLAVTVWAGRKTKDATDYYAGGRSFTGFQNGLAISGDYMSAASFLGIAGAIALAGYDGFLYSIGFLVAWLVALLLVAEPLRNSGRFTMGDVLAYRMRQRPVRTAAGVSTIVVSIFYLLAQMVGAGALVALLLGITGDAGKNLIVVLVGLVMILYVTIGGMKGTTWVQIIKAVLLILGTLLITILVLAKFDFNISQLLGAAADNSGKGASFLEPGLKYGVTTTSKIDFISLGIALVLGTAGLPHILIRFYTVPTAQTARKSVLWAIGIIGGFYLMTIALGFGAAALIKQETIIESNPAGNTAAPLLAEEVGGGAGSTGGAVLLAMISAVAFATILAVVAGLTLASSSSFAHDLYANVIRKGKATEKEEIAAARIAAVGIGAVAILLGVFAGSLNVAGLVALAFAVAASANLPTILYSLFWKRFTTQGALWSIYGGLFTSVLLVLFSPVVSGKETSMWPGVDFQWFPLENPGLISIPAGFILGWLGSILSKDEDATGKKYAELEVRSLTGAGAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFE3</accession>
    <name>A0A0F7NFE3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_32645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019411.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86184">
        <property type="protein sequence ID" value="AKH86184"/>
        <property type="gene ID" value="AA958_32645"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_32645"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6896"/>
    <dbReference type="OrthoDB" id="655500at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003346">
        <property type="entry name" value="Transposase_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002525">
        <property type="entry name" value="Transposase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01548">
        <property type="entry name" value="DEDD_Tnp_IS110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02371">
        <property type="entry name" value="Transposase_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEDD_Tnp_IS110" evidence="1">
        <location>
            <begin position="10"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="400" mass="43404" checksum="1BE8080F4E41AC72" modified="2015-07-22" version="1">MNERKAQVWAGVDAGRGHHWAAVVDETGATLWPKKIDNDESAILTALGEILGLADEVHWAVDIAGTSSALLLALLAAHGQRAVYVPGRTVNRMSGAYRGEAKTDARDAYVIAETTRHRNDFATIDVPAQLAADLALLTAHRTDLVADRVRMINRPRDVLTGVFPALERAFDYSAHKGALVLLTGYQTPAAIRRRGRARLAAWLANRAVRGADAVAATALEAARAQQSALPGEDVAAQIIADLAAQILDLDDRLKRIDKQIRERFRSHPQAEIIESLPGVGPILGAEFIVAAGDLSAYADAGHLASAAGLVPVPRDSGRRTGNLHRPKRYSRRLRRVFYLSAQTSIIREGPNRDFYLKKRGEGCKHVQAVIALARRRASVLWALLRDGRVFTSAPPVTHAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFI0</accession>
    <name>A0A0F7NFI0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptide ABC transporter ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_25430</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020407.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_25430"/>
    <dbReference type="EnsemblBacteria" id="AKH87031">
        <property type="protein sequence ID" value="AKH87031"/>
        <property type="gene ID" value="AA958_25430"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_25430"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5360"/>
    <dbReference type="OrthoDB" id="1303270at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
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        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="13"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="56"/>
            <end position="63"/>
        </location>
        <ligand>
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        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH87031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="342" mass="37962" checksum="315C3BE970E308E7" modified="2015-07-22" version="1">MRKKPAAGTEPLLKVSGLTKHFPIRKGLMQRQVGAVQAVDGIDFDVLPGETLGVVGESGCGKSTMGRLITRLLEPTGGTVEFQGRDITHLSTGQMRPLRRDVQMIFQDPYSSLNPRHTVGTIVGAPFKLQKVRPEGGVKKEVQGILERVGLNPEHYNRYPHEFSGGQRQRIGIARALALQPKLIVADEPVSALDVSIQAQVVNLLDDLQQEFGLTYVIIAHDLSVVRHVSDRIAVMYLGKIVELADRTSLYQEPLHPYTKALMSAVPVPDTKRRQQRERILLNGDVPSPISPPLGCRFHTRCWKATQVCKTKEPPLLELKPGRRTACWHPENAPDQAPEDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFR2</accession>
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    <organism evidence="1 2">
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AKH85567">
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        <property type="gene ID" value="AA958_28725"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_28725"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6054"/>
    <dbReference type="OrthoDB" id="2009249at2"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR046156">
        <property type="entry name" value="DUF6158"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19655">
        <property type="entry name" value="DUF6158"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH85567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="80" mass="8968" checksum="7F4BF63B5F96B6B1" modified="2015-07-22" version="1">MGESDRRRGGIAPARLTDQQLIRELETIHRTRHDTLLHGSAAALAMHNTRMAQLEGEYLSRHPERSVALGRTRAGARERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFT2</accession>
    <name>A0A0F7NFT2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_30990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020588.1">
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_30990"/>
    <dbReference type="EnsemblBacteria" id="AKH87161">
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        <property type="gene ID" value="AA958_30990"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_30990"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6549"/>
    <dbReference type="OrthoDB" id="447734at2"/>
    <dbReference type="Proteomes" id="UP000034283">
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    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH87161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="419" mass="44135" checksum="688432FC7AEBBD0A" modified="2015-07-22" version="1">MGAAALAAPAAGSLAACGGSASGDSSSLDLVYLGDATQQEAFNALFAEFNKSKPKVKIKARGIAAETWGNFANTVSTQIAGGKVPDIVQVATEGQRLFASKDLLEPLDPYLDRDKKIVEDYFSDTDPKLREWTETYGSTDGKTYYIPGGYNTSVLYCNTKVFADAGVDLPEAEWTWDDFRAAGERIKAKTGAFLLPAGFAFPFLDIMPWLLTNGASTHNAAWDEATFDSPAAVEAAEYVKSLIDAGLSPKPGGNFNAAGQLRKGKLAAFGAGRWATLDMRRLGLTDSVRIVPWPSNAQAGATVGWDGWPILRASRNKDAAWEFLTWMMSKEASTFYASAGGTNIPARNSVAAGPAFTDDAPAGTENLPAALGYGTPIPSPERGAEAQAAITQGWQAAILGNQPAAEALGSANDKLSGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NH08</accession>
    <name>A0A0F7NH08_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">Thiazole synthase</fullName>
            <ecNumber evidence="4 6">2.8.1.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">thiG</name>
        <name evidence="9" type="ORF">AA958_06650</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 6">Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>1-deoxy-D-xylulose 5-phosphate + 2-iminoacetate + [sulfur-carrier protein ThiS]-C-terminal Gly-NH-CH2-C(O)SH = 2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + [sulfur-carrier protein ThiS]-C-terminal Gly-Gly + 2 H(+) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:26297"/>
            <dbReference type="Rhea" id="RHEA-COMP:12908"/>
            <dbReference type="Rhea" id="RHEA-COMP:12909"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
            <dbReference type="ChEBI" id="CHEBI:62899"/>
            <dbReference type="ChEBI" id="CHEBI:77846"/>
            <dbReference type="ChEBI" id="CHEBI:90619"/>
            <dbReference type="ChEBI" id="CHEBI:90778"/>
            <dbReference type="EC" id="2.8.1.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 6">Cofactor biosynthesis; thiamine diphosphate biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homotetramer. Forms heterodimers with either ThiH or ThiS.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ThiG family.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.10" evidence="4 6"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_06650"/>
    <dbReference type="EnsemblBacteria" id="AKH86583">
        <property type="protein sequence ID" value="AKH86583"/>
        <property type="gene ID" value="AA958_06650"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_06650"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1387"/>
    <dbReference type="UniPathway" id="UPA00060"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990107">
        <property type="term" value="F:thiazole synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04728">
        <property type="entry name" value="ThiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00443">
        <property type="entry name" value="ThiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033983">
        <property type="entry name" value="Thiazole_synthase_ThiG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008867">
        <property type="entry name" value="ThiG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34266">
        <property type="entry name" value="PTHR34266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05690">
        <property type="entry name" value="ThiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0704">Schiff base</keyword>
    <keyword evidence="5 6" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ThiG" evidence="8">
        <location>
            <begin position="1"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="DXP binding" evidence="6">
        <location>
            <begin position="167"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="DXP binding" evidence="6">
        <location>
            <begin position="189"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="226"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with DXP" evidence="6">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>1-deoxy-D-xylulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH86583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="259" mass="26589" checksum="2DE3E2F16DE72E07" modified="2015-07-22" version="1">MGTGGASSLDLMERALLASGTELTTVAMRRVDPGVHGSVLDVLRRHGIRVLPNTAGCYTAGEAVLTARLAREALGTDWVKLEVIADERTLLPDPVELLAAAETLVDDGFTVLPYTNDDPVLARKLEDAGCAAVMPLGSPIGSGLGIRNPHNFQLITEAAGVPVILDAGAGTASDAALAMELGCDAVMLASAVTRAQEPVLMAEAMRYAIAAGRLAARAGRIPRRHFARASSPGAGVAELGPGGGRDEGPGPDPERPAFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-12-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NHP4</accession>
    <name>A0A0F7NHP4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_33150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019492.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86267">
        <property type="protein sequence ID" value="AKH86267"/>
        <property type="gene ID" value="AA958_33150"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_33150"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.7003"/>
    <dbReference type="OrthoDB" id="1389691at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="141"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="273" mass="28312" checksum="4867807509B3F46E" modified="2015-07-22" version="1">MIPSEPPGAGPALAETVRGLQERAARALPAEVVEHADGWWLRHDSGSSWWVASVLPHGPDGPGGPGTSAATAGLARRVARAEEFYARHGGTARFQITPDACPAGLDALLAGRGYDRSHPVSLQAAAVAEIPGQRAGGPLRVRIEDRPVDAWFGVWLAVRGEGAGAAAWGLLDRVAGPSAYARVLHGDETVAVGRAVADSGWAGVFAMATLPAARGRGAGGRVLGALAEWAGAHGATGLYLQVERDNPAALRLYARAGFREVCTYHYRTAGAKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NIC8</accession>
    <name>A0A0F7NIC8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_24700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_24700"/>
    <dbReference type="EnsemblBacteria" id="AKH87018">
        <property type="protein sequence ID" value="AKH87018"/>
        <property type="gene ID" value="AA958_24700"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_24700"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5209"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="32"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="453"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH87018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="548" mass="59678" checksum="85A68DB610BF784B" modified="2015-07-22" version="1">MWGTLVRPGRKEADAYRTAGWWRDETFLDDLEAAARSRPAHPAIIAYEGRDHARTLTYAELADVVERFAAALAALGVGRGDVVALYMPNRWQLTPLFLACHRIGAVTSPVIPALDVRELAYVLTESGAKVCVTVDRIGETDYGARLAEAAPKTLAHRVVIGDAAASGALDFEGFFVRTDHPPVASAAPLGPDDPSLLLYTSGTTGRMKGVVHSQNTLHAAVLAVSRPHRLTAGDIISIPAFATHMAGLTYACYMPLLLHATCVTQSDHLDVELFLDLLAEHRITWAYAAPARLVDMLEIQRAQPRDTSAVVQVVSGSAPIQPRLISEMRKVFDLPVRALWGMTENGAVTVTRDGDPEGWAAHSDGRAEPSMEVRIDAGPGKPEPAVGRLLVRGASQCLGYLGQREVYEACLDADGWFDTGDLARHDGRGGIRITGRRVDQINRANGQKIATLEVESVLTRHPNIREVALVGYPDPQLPTAELVCAVVVADGEPPTLESVHAHLAAEKMARVLWPDRVQFVWELPKNSLGKVLRHPLRERLEIEYAARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NIM5</accession>
    <name>A0A0F7NIM5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Mucin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_29845</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020540.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_29845"/>
    <dbReference type="ESTHER" id="9actn-a0a0f7nim5">
        <property type="family name" value="UCP031982"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH87128">
        <property type="protein sequence ID" value="AKH87128"/>
        <property type="gene ID" value="AA958_29845"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_29845"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6303"/>
    <dbReference type="OrthoDB" id="685252at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047746">
        <property type="term" value="F:chlorophyllase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015996">
        <property type="term" value="P:chlorophyll catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017395">
        <property type="entry name" value="Chlorophyllase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07224">
        <property type="entry name" value="Chlorophyllase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH87128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="293" mass="30522" checksum="C26464AE7F8A8755" modified="2015-07-22" version="1">MAGTTGAASPAVAAPAAARPAPRPALLRQAPAQDFAIGVREYNWSRGGRRLFTKIFYPATGTPGGNPVPNAPLADGVFPVAHWNHGAYGNSDSYASQTHAIASAGFICPAPSISDNTNIGSVYGGEWSKDVSEVITQTLALNDASGSPFAGQIDTAAGVGVSGHSMGGMTVHGLLTKWPDDRIKAAVPVACVDMGDPAGLDANVLFIHGDQDPTCQYGLARQAYGELSAPKAFLTHVGADHAAYLNPGFRTFDQTQNTLVDWFRWSLYGDTAARDRLPAGATAPGTRWESVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NIQ0</accession>
    <name>A0A0F7NIQ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_10430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019935.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_10430"/>
    <dbReference type="EnsemblBacteria" id="AKH86667">
        <property type="protein sequence ID" value="AKH86667"/>
        <property type="gene ID" value="AA958_10430"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_10430"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2196"/>
    <dbReference type="OrthoDB" id="1983417at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH86667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="85" mass="9816" checksum="C4C454C956B0C93D" modified="2015-07-22" version="1">MHDDLIDHLTRSAPLSRGEAARVVQDVLAYFDETTPAFVRRRHRELQAAGLVNDEIFDRIARELAHRAVAPPELTRRQLRRLVYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NJA4</accession>
    <name>A0A0F7NJA4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bacterial PH domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_18375</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_18375"/>
    <dbReference type="EnsemblBacteria" id="AKH86867">
        <property type="protein sequence ID" value="AKH86867"/>
        <property type="gene ID" value="AA958_18375"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_18375"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3858"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005182">
        <property type="entry name" value="DUF304"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03703">
        <property type="entry name" value="bPH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="bPH_2" evidence="2">
        <location>
            <begin position="79"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH86867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="170" mass="19212" checksum="BC91B6A219D62B27" modified="2015-07-22" version="1">MPIADRYLAEDESLVYVTRQHWTTLVNEFLALCVIAVAAGALVWWLPTDEDWGTYTSFGVLAVAAIFACYFWLVPLLQWRSTMYILTTKRLHKRSGFLSKSGRSIPLSRVNDVSFRANLWERIMRYGTLNVQSASEQGVMTLRHVPDPEGLKAEIYRAVDALGGGSEPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NJL5</accession>
    <name>A0A0F7NJL5_9ACTN</name>
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        <submittedName>
            <fullName evidence="1">Rrf2 family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_23000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020342.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_23000"/>
    <dbReference type="EnsemblBacteria" id="AKH86977">
        <property type="protein sequence ID" value="AKH86977"/>
        <property type="gene ID" value="AA958_23000"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_23000"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4846"/>
    <dbReference type="OrthoDB" id="1794390at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000944">
        <property type="entry name" value="Tscrpt_reg_Rrf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33221">
        <property type="entry name" value="PTHR33221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02082">
        <property type="entry name" value="Rrf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00738">
        <property type="entry name" value="rrf2_super"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51197">
        <property type="entry name" value="HTH_RRF2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH86977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="152" mass="16297" checksum="9A38B51918613CD6" modified="2015-07-22" version="1">MRISARADYAVRAALELAAATEEAPVKAEAIADAQGIPHKFLESILGDMRRGRLVVSQRGGRGGYRLAAPADEITIADVIRVVEGPLVSVRGARPPELSYVGPAESLLPLWIALRVNVRRILGEVTLADVASARLPGYVHELAEDPDAWTNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MY00</accession>
    <name>A0A0F7MY00_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_01855</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014484.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_01855"/>
    <dbReference type="EnsemblBacteria" id="AKH81120">
        <property type="protein sequence ID" value="AKH81120"/>
        <property type="gene ID" value="AA958_01855"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_01855"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.403"/>
    <dbReference type="OrthoDB" id="2031899at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="25"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH81120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="85" mass="9231" checksum="D52FFFEF9A140205" modified="2015-07-22" version="1">MATETDTSAVVSELAEIRRSLDVGLARIDGRLALLSQRSQQMEREIDELTARVTSLEHSRWPLPSIAALTGAGAMALALWQALGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MYP0</accession>
    <name>A0A0F7MYP0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_00185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH80846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014213.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH80846">
        <property type="protein sequence ID" value="AKH80846"/>
        <property type="gene ID" value="AA958_00185"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_00185"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.42"/>
    <dbReference type="OrthoDB" id="1924759at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH80846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="112" mass="12205" checksum="FA33D1EB71B29809" modified="2015-07-22" version="1">MLQIQLPPRRPTDPAGDALHRSSIGWFPGMSEDEAWLAGRGVWKLNADRALAQDEVQIIDSDGLVLAVAEITGIRKCDGGRFALEGTLRHGDARVGKPTATPHRSRNSVAYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MZG1</accession>
    <name>A0A0F7MZG1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase C69</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_05130</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase U62 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015035.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_05130"/>
    <dbReference type="EnsemblBacteria" id="AKH81680">
        <property type="protein sequence ID" value="AKH81680"/>
        <property type="gene ID" value="AA958_05130"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_05130"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1078"/>
    <dbReference type="OrthoDB" id="806701at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045569">
        <property type="entry name" value="Metalloprtase-TldD/E_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002510">
        <property type="entry name" value="Metalloprtase-TldD/E_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035068">
        <property type="entry name" value="TldD/PmbA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036059">
        <property type="entry name" value="TldD/PmbA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01523">
        <property type="entry name" value="PmbA_TldD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19289">
        <property type="entry name" value="PmbA_TldD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111283">
        <property type="entry name" value="SSF111283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PmbA_TldD" evidence="2">
        <location>
            <begin position="36"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="PmbA_TldD_C" evidence="3">
        <location>
            <begin position="255"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH81680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="509" mass="54539" checksum="7814CBFF8D61E57C" modified="2015-07-22" version="1">MSKSVHSLDDGFLALPLSALADAALARARALGAEHADFRLERVRSAALRLKDAKLAGSTDTTDLGYAVRVVHGGAWGFAAGVDLTMDAAARVAARAVAMAKLSARVIAAAGADERVELAPEPVHAEKTWISAYEVNPFDVPDADKTGLLTEWSERLLAAPGISHVDASLLAVQENKFYADTAGTSTTQQRVRMHPELTAVTVTDSGDFDSMRTLAPPAGRGWEYATGTGWDWDEELARIPGWLAEKLAAPSVEAGSYDLVVDPSNLWLTIHESVGHATELDRALGYEAAYAGTSFATFDQLGTLRYGSGLMNVTGDRTAEHGLASIGYDDEGVQAQSWDLVREGVLVGYQTDRRIAKLTGFDRSNGCAYADSPAHVPVQRMANVSLQPAPEGPTTEELIGEVERGIYVVGDRSWSIDMQRYNFQFTAQRFFRIENGRLAGQLKDVAYQATTTDFWGSMSAIGGPETYVLGGTFSCGKAQPGQSASVSHGCPSALFRNVNILNTTQEAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MZI5</accession>
    <name>A0A0F7MZI5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GRAM_POS_ANCHORING domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_05290</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015064.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_05290"/>
    <dbReference type="EnsemblBacteria" id="AKH81710">
        <property type="protein sequence ID" value="AKH81710"/>
        <property type="gene ID" value="AA958_05290"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_05290"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1110"/>
    <dbReference type="OrthoDB" id="1800937at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019931">
        <property type="entry name" value="LPXTG_anchor"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50847">
        <property type="entry name" value="GRAM_POS_ANCHORING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0134">Cell wall</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0572">Peptidoglycan-anchor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0964">Secreted</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002518966" description="GRAM_POS_ANCHORING domain-containing protein" evidence="6">
        <location>
            <begin position="26"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="300"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="GRAM_POS_ANCHORING" evidence="7">
        <location>
            <begin position="289"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="248"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH81710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="325" mass="32135" checksum="7C2562FEB3B73FCA" modified="2015-07-22" version="1">MSATAVTAAALAAGPALLVAAPVYADDAGGTAPARTGSAGASVLRADLDVSLLDKTVQVPVLSTLNEVRVPAAGRDSGAADKTALDVRVDGLAAAGGGEHPEGPRAVNIARAEVATADATVDVYGAEASSHLARAEVHVPGLPALPLIKVEEVTSKAVCAVGEKPKAESRTLGSVTVLGKRVTVTVGGEPTVVAVPGVGEVSLGFSQTETTRAAASAAALRLRVSVNPLKLNVAEVEGEVTLVEAACETPAGGGTGPGEEPGDRPQGDAEPVQDERPADATDPAPERQLAETGGSSATPYLVGGAALLVGLGLSGLVLARIRTRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0I7</accession>
    <name>A0A0F7N0I7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AA958_00670</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNQ-509</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH80923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014289.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_00670"/>
    <dbReference type="EnsemblBacteria" id="AKH80923">
        <property type="protein sequence ID" value="AKH80923"/>
        <property type="gene ID" value="AA958_00670"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_00670"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.154"/>
    <dbReference type="OrthoDB" id="1123553at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033068">
        <property type="term" value="P:macrolide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015083">
        <property type="entry name" value="Polyketide_synth_docking"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036299">
        <property type="entry name" value="Polyketide_synth_docking_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08990">
        <property type="entry name" value="Docking"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101173">
        <property type="entry name" value="SSF101173"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="2 7" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="1699"/>
            <end position="1774"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="3235"/>
            <end position="3310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="3362"/>
            <end position="3391"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="7">
        <location>
            <position position="1734"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="7">
        <location>
            <position position="3270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AKH80923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="3406" mass="353702" checksum="BE454D887FDB8C78" modified="2015-07-22" version="1">MAEEDKLRDYLKRLTVDLRRTTRRLREVEEQRREPVAVVGMACRLPGGVQSPEGLWELLRDGRDAISAMPANRDWHLDDHFDPDLGGPGTSYVREGGFLDDIAGFDAAFFGISPREALAMDPQQRLLLELAWESVERAGIDAHTLRGSRTGVFVGSNPTEYGGLLGDAAAQVGGHLLTGTVLSVLSGRLAYTLGLEGPAVSVDTACSTSLTAVHLAVQALRRGECTMALAGGATVFSTVGPFTEMSRQRVLAADGRCKAFGAGADGMGMSEGGGVVLLEPLSAARHNGHRVLAVIRGSAVNSDGSSNGLTAPSRQAQEKVIRAALADAGLGAADVDAIEAHGTGTELGDPIEAQALLEVYGRGRAAAGAPLYLGSVKSNIGHTQAAAGVAGLMKLVLALEHGELPRTLHADAPSPHVDWDPATLALLGEALPWRGGERTRRAAVSAFGISGTNAHVILEQPPADEQEPTPTAPAGGPAGPWLVSAATADGLRAQAARLAGHLRARPELSVDAVGHALATSRATLGHRAVLLGTDRAELLGRLDALGRGDAAAGLVTGVQQSGRLALMFSGQGSQRPGMGRELYEAFPVFAEALDEVCTALDAHLDAPVREVMFAAAGTERAELLEHTLYTQPALFAVHTALARLLRSWGVRPDHLIGHSVGELSAAHVAGVLPLDVAADMVATRAKLMHSLPESTGMLAVRSGPEPLAGHLERHAGVEIAAYNSPAATTLAGPLDALDALARELADAGIRARRLKVAHAFHTAHTEPVLDAFARHLTDLFARHAPGQAEIPVISNVTGLPATDGQHHDPAYWAEHIRRPVRFHQGVAGLAGLGTTTYLELGPDATLSTLAQAVLDEADPAQPGAEPAVVTAALRRDHPEVPALFAAVARLHVHGTEVDWRPLHGEGRPAELPTYAFQRRPYWLRPARPAADQPGVRVTRHPLLGAVLETADAERPGTVCTGRISARTPGWLADHVLGTTVVLPGTGAVEIALCAARHVGCARVEELTLRQPVVLPTEGAMQLQVAVDAPDADGRRALSLYARPEPDAAETGEDAAGLAADSPWTLHATGVVAPDAGAASGVWDGTAWPPPGEPAAVVDDLYDRLHERGMRFGPAFRSLRTVWRDGEHLYADLALPEAQHADLDEYGIHPALLDAALHTVALLDESGTELRLPFTWSGVRLLARPGAAALRARVTPTGPETVALDLADAAGTPVLRVDEVALRPVPADSLGAVSADPLYGVEWRRLDAAPEAADGAELWETDLDAFAAGTVPERAGVVVVQCPAADGADDATAERARTTVARVLAAVQRWLSDDRFADSRLAVVTRGAVGADTAGDVPALESAPVWGLLRSAQSEHPDRIVLVDDDPAERSALPVAEAVRAALVAGEPQLAIRDGALLAPRLTRIAPEGPAALDPEGTVLVTGAGGTLGGQVAAHLVTAHGVRRLLLVSRRGEAAPGAGELRAELTGLGAEVAFAACDVADADALREALAGIPSEHPLTAVVHAAGVLDDATVGELTPAQLDAVLRPKTDGAWHLHRLTADLPRVAFVLFSSFASVVGTPGQANYAAANSFLDALAQHRRARGLPAVSLAWGLWEQGGMGGGLDRAARARIARAGVRAMPASRALALLDTALRSPVALAAPVVLDRRALRTRSRAGTLPAVLRAQAPAPAAPAEGTASTAAPAADPLAGLAALGRAEQDRTLLALVRRTAVLALGLPEGESVSPGQTFRDLGFDSLTAVEMRNQLSAATGRRLPATAVFDHPTPQALADHLRAELLESERAAAPAVPATAARAADVDDPIAVVAMSCRYPGGVDSPADLWDLLSRGAEGTSTFPENRGWDIDAIYDPSGERPGTTYTRAGSFLHDADRFDAEFFGISPREAASMDPQQRLLLELCWEAVEGAGIPADELRGSATGVFAGIMYSDYGGRLLLRTPAEYEGYVGNGSAPSVASGRIAFTFGFEGPALTVDTACSSSLVALHLAAQSLRNGECTLALAGGATVMSTPAVFVEFSRQRGLAPDGRCKSFADSADGTGWGEGAGVLLLERVSDAERNGHQVLAVLRGSAINQDGASNGLTAPNGPAQQRVIRQALANARLTGAEVDAVEAHGTGTTLGDPIEAQALLATYGREHSAERPLWLGSVKSNLGHTQAAAGVAGVIKMIQAMRHGVLPRTLHVDEPSQHVEWDAGVVSLLTEEREWPRAGADRPRRAGVSAFGISGTNAHVILEEAPAVAQEAPAEPPQPAGAALPWLVSGATPEGLSAQAARLAERIQARPELSAPDLAWSLASRRAALPYRATVLGRDRAELLDGLREVAQDRSAPGVIRTRGEQRPGGLVFMYSGQGSQRPGMGRELYEALPVFAEALDEVCAALDVHLDLPVRDVMFADATDDGSSLLNQTLYTQTGLFALHTALTRQLRAWGVQPDHLIGHSIGEVTAAHVAGVLSLTDAARLVTARARLMNELPHGTGGMLAVQAGPEALAEHLERHGRAEIAAYNSPAATVLAGPSDALAALGEELGAAGIRTRGLKVSHAFHSAQMDPVLPEFTSIAGGLTYRAPDLPVVSNLTGAAATADELTDAAYWAEHIRRPVRFHQGLTHLVGEGATTFLEIGPGAALTALARAVLPDDGDAAAIPSLRPARKAGDGDAPAPPSDEPTALLHAMGELHAIGAGPRWTDVLPRGRTVELPTYAFQRRRYWIDPVEPAAAAPADSGLHYRTSWARLPRGGGAVLDGTWLLAAPADGRAGEWPEFCAAALGEAGAKVATVEIAAGTERAPLAEQLARRIEETGQPRGILSLLAVRADSAGGAGTAGAADPAADGVPEELTATVLLTQALGDAGVAAPLWAATSQAVSVGDGDPLGNPEAALVWGFGRAAALEEPARWGGLIDLPGTPAGLDARGRAELAALLGGAPDGSGAPAEDQIALRADGPRARRLRRTTPARKADAQWPPRGTVLVTGGTGGLGAHAARWLAANGAGHLLLVSRRGPAAPGADELRTELTGLGAEVTIAACDVTDRAALAALLAGVPEETPLTAVLHAAGVSVDRGLADLDAKHFAEVLGPKSLAARHLHELTQDADGGSRLSAFVLFSSTAGVWGSGAQGAYAAGNAYLDALAEHRRARGLPATAVAWGAWSGEGMAGDGENSRRLLRRGIRGLDPGAAVAALAEAVRADEAPTTIADIDWSAFTLAFTSRRPSPLLGELPEARAVLDAREEAEPEPAGTDAAARLRSLLAGRTREEQQRELLDLVRTEVAGVLGHASAEGVRPGKPFNDLGFDSLTAVELRNRVNSRTGLRLPTTVVFDYPTPDALAACLRDELGGPDPAGQSVLADLARLDGALSGAALADEEVRRQAGERLRTMLQRLDGSAPYAAENGHAAGGGPDGGAAGGEADSDLESASVDDLLDIIQTEFGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0M2</accession>
    <name>A0A0F7N0M2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alkyl sulfatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_00495</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallo-beta-lactamase superfamily. Type III sulfatase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH80894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014260.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_00495"/>
    <dbReference type="EnsemblBacteria" id="AKH80894">
        <property type="protein sequence ID" value="AKH80894"/>
        <property type="gene ID" value="AA958_00495"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_00495"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.115"/>
    <dbReference type="OrthoDB" id="775108at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018741">
        <property type="term" value="F:alkyl sulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018909">
        <property type="term" value="P:dodecyl sulfate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07710">
        <property type="entry name" value="arylsulfatase_Sdsa1-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038536">
        <property type="entry name" value="Alkyl/aryl-sulf_dimr_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029229">
        <property type="entry name" value="Alkyl_sulf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029228">
        <property type="entry name" value="Alkyl_sulf_dimr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044097">
        <property type="entry name" value="Bds1/SdsA1_MBL-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036527">
        <property type="entry name" value="SCP2_sterol-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14864">
        <property type="entry name" value="Alkyl_sulf_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14863">
        <property type="entry name" value="Alkyl_sulf_dimr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55718">
        <property type="entry name" value="SSF55718"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Lactamase_B" evidence="5">
        <location>
            <begin position="88"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00033751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH80894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="605" mass="65242" checksum="15AFBC8454170D77" modified="2015-07-22" version="1">MATPDPIDRGDFEAADRGFLAGPAERQVTAADGRVVGDFDDTAFLSSLPDGNHPDTVDPSLWRQAKLCARAGLYEVTEGVLQVRGYDLSNMTLIEGDQGVVVVDPLISRETAAAALALYRAQRGDRPVTGVVITHSHLDHFGGILGVLDQDADVPVVAPAGYLEHAVAENVYAGTAMLRRGFYYGGMNLERGPTGLVGTGLGFTASTGTPALLPATTDITHTGQTETVDGVRFVFQMTPGTGAPSEMNFLLPDHRALCMAENATHNLHNILTLRGAVVRDARVWARYLDEALRLFAAGADVLFASHHWPTWGQQAMRDFLTEQRDLYAYLHDQTLRLANQGCTGTEIAEIIEMPPSLAAAWHTHGYHGTVSHNVKAIYQRYLGWYDGHPASLWEHPPAETAKRYAECMGGVDALVAKASAYAEDGDLRFAAQLLKHAVFADPDHTGARNTLAGVFERLGHGAECATWRNCYLVGARELREGVGRTDIAASSLMAALSVEQLLDSVAIVVDGPRAWDLHLTLDWHVTDLGEHHRATLSHGAFTHHRLDGHAAEPADVSLTLTKAQLPALLAGGDPEDIEHTGDLGVLRTLLSVLDEPDPDFAVVTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0R7</accession>
    <name>A0A0F7N0R7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AsnC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_01120</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH80998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_01120"/>
    <dbReference type="EnsemblBacteria" id="AKH80998">
        <property type="protein sequence ID" value="AKH80998"/>
        <property type="gene ID" value="AA958_01120"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_01120"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.247"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH80998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="147" mass="16518" checksum="4C62672CDBCF6796" modified="2015-07-22" version="1">MDLEILRVLQNDARTTNRDLAAAVGVAPSTCLDRVARLRRAGVITGHRLAIDPARLGRGLEALLSVQVRPHRRDLIGPFVERVRSLPESRALFHLTGPDDYLLHVAVRDAADLQRLVLDEFTSHREVARVETRLVFQHWECGPLLPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N130</accession>
    <name>A0A0F7N130_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_01595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014438.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_01595"/>
    <dbReference type="EnsemblBacteria" id="AKH81074">
        <property type="protein sequence ID" value="AKH81074"/>
        <property type="gene ID" value="AA958_01595"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_01595"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.350"/>
    <dbReference type="OrthoDB" id="1259001at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="292" mass="30781" checksum="2B1A12DDFF2F2139" modified="2015-07-22" version="1">MVRTRTDARLLRREMPGAVGLLADAADFAEMRRYASFLFDDHAAYLRQVEGILRARATQGAYTTVALFDPPGFARFCAERGLEPDTPASRCRYVAESAARGPAVAYGGQPMDRLVPQLLDAAARSRSRERAATLLAAAGRCEDCGEHRADAALARAGLLVDRLTGALGPGGQHVVATVRSAGFPLVAVARSADPPGPPRLRPPDGEALRLVLAAGIATSGTGGVVARTTGSDGGESVRGWRLRDGWLAPLTEKEVYAAYCTNARTGAPLPPEPGVTYSAGTPLPRPEKGCHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-10-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N151</accession>
    <name>A0A0F7N151_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_01740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014463.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH81099">
        <property type="protein sequence ID" value="AKH81099"/>
        <property type="gene ID" value="AA958_01740"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_01740"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.380"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH81099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="84" mass="9550" checksum="D13100D35F4011A3" modified="2015-07-22" version="1">MYEPARHRRARRRARPLIAGAEVYFGVAYVCDRLGLNSEPPLGQRQPVRRGLGPVYLIAGDDHGGNEHQYLLCHRSTTDSSQYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N1P3</accession>
    <name>A0A0F7N1P3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase</fullName>
            <ecNumber evidence="6 7">6.3.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">D-alanyl-D-alanine-adding enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">murF</name>
        <name evidence="11" type="ORF">AA958_06550</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>ATP + D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine</text>
            <dbReference type="Rhea" id="RHEA:28374"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57822"/>
            <dbReference type="ChEBI" id="CHEBI:61386"/>
            <dbReference type="ChEBI" id="CHEBI:83905"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6 7">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MurCDEF family. MurF subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.10" evidence="6 7"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="term" value="F:UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="F:UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
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        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="MurE/MurF_N"/>
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    <dbReference type="InterPro" id="IPR005863">
        <property type="entry name" value="UDP-N-AcMur_synth"/>
    </dbReference>
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        <property type="entry name" value="Mur_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF63418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01143">
        <property type="entry name" value="murF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1 6 7" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 6 7" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5 6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 6 7" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase" evidence="8">
        <location>
            <begin position="31"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_M" evidence="10">
        <location>
            <begin position="112"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_C" evidence="9">
        <location>
            <begin position="324"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="113"/>
            <end position="119"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU004136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF01225"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AKH81926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="475" mass="49363" checksum="91777CBE1DB18BD5" modified="2015-07-22" version="1">MIPLSLAEVAELTGGELHGVPDPQALVTRPVVIDSRQAEPGSLFAAFTGEHVDGHDYAALAVAAGATGVLGTRPVEGVPTVVVSSVPPALSALAKHVVARLDETLTALIALTGSSGKTSTKDLLAQLLQRLGPTVYTHGSFNNEIGHPVTALQAAPDTRYLLLEMGARGLGHIRDLAEVTPPRIGLVLNVGTAHIGEFGGREQIAAAKGELVEALPAGADGGVAVLNADDPLVRAMASRTRARIIYYGEAPEADVRAADVRLTEDGRPEFTLHTPAGSAGVIMRLYGEHHVSNALAAAAVAYELGMPPARIAEALSAAEALSGRRMEVRRRPDGVTVVNDAYNANPESTRAALRALAAMGRGSTVPGGRTFAVLGAMAELGDHAMVEHDGVGRLAVRLGISKLVAVGRQEAAWLDMGAKNEGSWGEESVHVSDVDAAVDLMRGELRPGDVVLVKASRSEALWRVAEALLEEGAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N1Z3</accession>
    <name>A0A0F7N1Z3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_06975</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82001.1"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:DNA-binding transcription factor activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GntR_C"/>
    </dbReference>
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        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
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        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
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        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
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        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
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        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
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    </dbReference>
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        <property type="entry name" value="SSF46785"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
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    </dbReference>
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        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="8"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH82001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="207" mass="22872" checksum="CE860628CAC7C020" modified="2015-07-22" version="1">MPPTVVHPSLREQIREHIVEGVVSGRWKPGERIVERRIAVELEVSQTPVREALRELESMRLIESAPNKGVRVRDLTAADLEEIYPVRAGLEQIAAELAAPRLATDVSALEPHVAALREADAKGDGGAQVRHTVAFHRELVRASGNGVLLHTWESLGIEIYTSLAIRWLGTRQQSYAEEHADIVEAFRRRDPAIAELVKSHVLGCAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N206</accession>
    <name>A0A0F7N206_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Nicotinate phosphoribosyltransferase</fullName>
            <ecNumber evidence="4 8">6.3.4.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AA958_10755</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O + nicotinate = ADP + diphosphate + nicotinate beta-D-ribonucleotide + phosphate</text>
            <dbReference type="Rhea" id="RHEA:36163"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32544"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1.</text>
    </comment>
    <comment type="PTM">
        <text evidence="8">Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the NAPRTase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.21" evidence="4 8"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015965.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_10755"/>
    <dbReference type="EnsemblBacteria" id="AKH82625">
        <property type="protein sequence ID" value="AKH82625"/>
        <property type="gene ID" value="AA958_10755"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_10755"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2262"/>
    <dbReference type="OrthoDB" id="241792at2"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00457"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004516">
        <property type="term" value="F:nicotinate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004514">
        <property type="term" value="F:nicotinate-nucleotide diphosphorylase (carboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040727">
        <property type="entry name" value="NAPRTase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007229">
        <property type="entry name" value="Nic_PRibTrfase-Fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006405">
        <property type="entry name" value="Nic_PRibTrfase_pncB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11098">
        <property type="entry name" value="PTHR11098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17767">
        <property type="entry name" value="NAPRTase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000484">
        <property type="entry name" value="NAPRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="SSF51690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01513">
        <property type="entry name" value="NAPRTase_put"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7 8" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NAPRTase_N" evidence="9">
        <location>
            <begin position="15"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AKH82625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="440" mass="46732" checksum="2702509AD01F0E73" modified="2015-07-22" version="1">MSELKLPVTVPSTALFTDHYELTMVQAALHAGTAGRRSVFETFTRRLPEGRRYGVVAGTGRVLDALESFRFEPEVLRFLRAHDVVDAPTLEWLADFRFTGDIWGYPEGEVYFPGSPVLRVEGSFAECVLLETVVLSILNHDSAIAAAASRMAVAAGGRPLIEMGARRTHELSAVAASRAAYVGGFASTSDLAAGFRYAIPTVGTAAHAFTLLHDSEREAFTAQIESMGVGTTLLVDTYDVEAAVRTAVEVAGPELGAVRIDSGDLLLVAHRVRQQLDELGAERTRIIVTSDLDEYAIASLAAAPVDAYGVGTRLVTGSGHPTCSMVYKLVARAASDAPDAPLAPVAKRSTGGKTSIGGRKWAARRLDAYGVAEAEVVGTGEVPAELAGRELLVPLVRGGKIVGREPMDDARARHVVARDGLPLSATQLSRGEPVLPTEYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N282</accession>
    <name>A0A0F7N282_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_00985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH80977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014343.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_00985"/>
    <dbReference type="EnsemblBacteria" id="AKH80977">
        <property type="protein sequence ID" value="AKH80977"/>
        <property type="gene ID" value="AA958_00985"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_00985"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.218"/>
    <dbReference type="OrthoDB" id="1828250at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH80977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="246" mass="24676" checksum="0CD10B2B8FD63DF8" modified="2015-07-22" version="1">MTATAVLRAEWIKITTLRGTVWSLACVLLVTAGFGVLASAALGGAETVDGDFDPLFSVLTGVGPGQIAAIVFGTLAVSSEYQSGLIRATLAAVPRRGLLYAAKLTHVGGLTFAVALPTTLLSFLIGGAALGDRALGLGDDGALLGVVGGAAYLTLMALLAAGLAAVLRSGIAVLGILIPFVLVVSMVLGVGSSAGVADYLPDRAGQQVLFADPPGGLQPLAGLAVTALWTAAAVLAGWWTLRRRDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2W9</accession>
    <name>A0A0F7N2W9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_12845</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016299.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_12845"/>
    <dbReference type="EnsemblBacteria" id="AKH82965">
        <property type="protein sequence ID" value="AKH82965"/>
        <property type="gene ID" value="AA958_12845"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_12845"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2702"/>
    <dbReference type="OrthoDB" id="1437290at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011075">
        <property type="entry name" value="TetR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19352">
        <property type="entry name" value="TetR_C_38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="18"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH82965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="217" mass="23350" checksum="A38C7D0507BAE858" modified="2015-07-22" version="1">MTGQVRTVDGRVAGRRGQATRTKLLACLGEMLDSSPYRDVKVIDVARRASTSPATFYQYFPDVEGAVLELAEQMAKEGAGLTGLVAGRSWTGKSGAQAAEELVDGFLGFWRRNEAILRVVDLGAAEGDKRFYKIRMKILNSVTKSLTESVRELQAKGKVDEGVHPAAVAGSLVVMLAGVAAHQKAFQTWGVKQADLKPSLALLVHLGMTGRKPPKQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N311</accession>
    <name>A0A0F7N311_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_05530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_05530"/>
    <dbReference type="EnsemblBacteria" id="AKH81748">
        <property type="protein sequence ID" value="AKH81748"/>
        <property type="gene ID" value="AA958_05530"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_05530"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1159"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH81748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="143" mass="14829" checksum="9E36BA031EC50792" modified="2015-07-22" version="1">MPRARPVPYAVAAAGAAGAGAADGQIRIRDIQGDTRISPLAGEQVTGVPGVVTAVRAFGSACGFWLQDPRPDTDPATGEGLFVFTGSPEVTPGDEVEVSGSVAEYYPGGKDAGLQSVTELRRWRGAEGRFWRDRAASTGLVTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N316</accession>
    <name>A0A0F7N316_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nitrogen fixation protein NifU</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_05565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015107.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_05565"/>
    <dbReference type="EnsemblBacteria" id="AKH81753">
        <property type="protein sequence ID" value="AKH81753"/>
        <property type="gene ID" value="AA958_05565"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_05565"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1166"/>
    <dbReference type="OrthoDB" id="1793654at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06664">
        <property type="entry name" value="IscU_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002871">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10093">
        <property type="entry name" value="PTHR10093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01592">
        <property type="entry name" value="NifU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NifU_N" evidence="1">
        <location>
            <begin position="6"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="150" mass="16613" checksum="8679ECF5DF4F205C" modified="2015-07-22" version="1">MKLDSMYQDVILDHYKHPHGRGLRDGDAEVHHVNPTCGDEITLRVKLDGRTIEDVSYEGQGCSISQASASVLNELLVGKELGEAQRIQERFLELMQSRGRIEPDDAMEEVLEDAVAFAGVSKYPARVKCALLSWMAWKDATAQALKEAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N355</accession>
    <name>A0A0F7N355_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_13510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016410.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH83080">
        <property type="protein sequence ID" value="AKH83080"/>
        <property type="gene ID" value="AA958_13510"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_13510"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2842"/>
    <dbReference type="OrthoDB" id="2158561at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH83080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="218" mass="22425" checksum="47BF187C4E0E18CA" modified="2015-07-22" version="1">MGTLTPGRIRLYAPADWFDLMADGGDRAATRARCAELVRLTYPRTAAERREQFTDALLAWHDVLYADGVLMNGIVTAPLPSSGEQAAWLVFAGVAEVPENPSDLDLGELMTSVFAEHYRAAPAYTEAYATDMGMGFGFVAQPALPRAAVAGVEGAGEDPVQVGLAGALATPAGGGLGLLVVGTSLNPLQAGELAGLVAVIAGRSVFVDEAQDGPAPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3B9</accession>
    <name>A0A0F7N3B9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 12">Anthranilate synthase component 1</fullName>
            <ecNumber evidence="5 12">4.1.3.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">trpE</name>
        <name evidence="15" type="ORF">AA958_06180</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11 12">Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>chorismate + L-glutamine = anthranilate + H(+) + L-glutamate + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:21732"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="4.1.3.27"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 12">Heterotetramer consisting of two non-identical subunits: a beta subunit (TrpG) and a large alpha subunit (TrpE).</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the anthranilate synthase component I family.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.27" evidence="5 12"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015217.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_06180"/>
    <dbReference type="EnsemblBacteria" id="AKH81864">
        <property type="protein sequence ID" value="AKH81864"/>
        <property type="gene ID" value="AA958_06180"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_06180"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1291"/>
    <dbReference type="OrthoDB" id="1786019at2"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004049">
        <property type="term" value="F:anthranilate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019999">
        <property type="entry name" value="Anth_synth_I-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006805">
        <property type="entry name" value="Anth_synth_I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005256">
        <property type="entry name" value="Anth_synth_I_PabB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236">
        <property type="entry name" value="PTHR11236"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04715">
        <property type="entry name" value="Anth_synt_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00095">
        <property type="entry name" value="ANTSNTHASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="SSF56322"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00564">
        <property type="entry name" value="trpE_most"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 12" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="10 12 15" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Anth_synt_I_N" evidence="14">
        <location>
            <begin position="29"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Chorismate_bind" evidence="13">
        <location>
            <begin position="236"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU364045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AKH81864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="517" mass="54959" checksum="95002A1F9429B190" modified="2015-07-22" version="1">MTTPDRETFRTLAKDRRVIPVVRRLLADGDTPVGLYRKLAGERPGTFLLESAENGRTWSRYSFVGVRSAATLTERDGRAHWLGTPPVGLPTGGDPLAALRATVEALHTPRDLHQGAEGRDALPPFTGGMVGYLGYDAVRRLERIGDSARDDLRLPEMTMLLTSDLAVLDHWDGSVLLIANAINHNDLDTGVDEAYADAVARLDAMTADLARPTAASAAPLPPSALPEYGELWGGAEFRAAVADIKERIRAGEAFQVVPSQRFETPCAASALDVYRALRATNPSPYMYLIRLPDTGAGGGAFDVVGSSPEALVKVEDGRALLHPIAGTRPRGATPQQDAALAEELLADEKERAEHLMLVDLGRNDLGRVCEPGSVEVVDFMSIERYSHVMHIVSTVTGRLAPGRTAFDVLTACFPAGTLSGAPKPRALQIIEELEPTRRGLYGGCVGYLDFAGDADTAIAIRTALLRDGTAYVQAGAGIVADSDPAAEDAECRSKAAAVLRAVSAAGHLSRAGRETAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3C8</accession>
    <name>A0A0F7N3C8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_14130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016508.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_14130"/>
    <dbReference type="EnsemblBacteria" id="AKH83180">
        <property type="protein sequence ID" value="AKH83180"/>
        <property type="gene ID" value="AA958_14130"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_14130"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2974"/>
    <dbReference type="OrthoDB" id="460405at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010290">
        <property type="entry name" value="TM_effector"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05977">
        <property type="entry name" value="MFS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="371"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="425" mass="43335" checksum="4C81FA99222ADBC8" modified="2015-07-22" version="1">MRRRVRFLDTRPLRSSPPYRALWIGTSASQLGAQITLVAVLAQVWDLTGSPVGTGAIGLATGVPMILFGLLGGTLADTVDRRTLVRATTAGQLLAAGALCAQALADNRNVVLLLALVALSTVFAALGAPARRTFPVRLLPADQVAAGLALNNVSFQFAMLAGPAAAGLIIARWGLPAAYATQAAAIAVATAAVLRLPPMHPEGVREKGGRRRAERGGWRIVLRRHTLWGSLATDLSATLLAMPVALFPLVNEVRFDGDPQTLGLFLSAVAVGGITAGLLSGTVTRVRRGGLVQLIAAAVWGAALACFGLAGPLWPALACLAVAGAADTVSVVTRSALVQLETPDAYRGRVSSVEHVIGVAGPELGNFRGGLVASATSATVSLVTGGLAAVAAIAAIAAANTPLRAYRTPAQEPTPPAQNAPAPCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3G5</accession>
    <name>A0A0F7N3G5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Inhibition of morphological differentiation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_14370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAD-like hydrolase superfamily. SerB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016536.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_14370"/>
    <dbReference type="EnsemblBacteria" id="AKH83220">
        <property type="protein sequence ID" value="AKH83220"/>
        <property type="gene ID" value="AA958_14370"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_14370"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3024"/>
    <dbReference type="OrthoDB" id="1472357at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006385">
        <property type="entry name" value="HAD_hydro_SerB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01490">
        <property type="entry name" value="HAD-SF-IB-hyp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH83220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="276" mass="30518" checksum="3B4B42CCAB570729" modified="2015-07-22" version="1">MLALVENHSLPRTAAFFDLDKTVIAKSSTLTFTRSFYHGGLMNRRAVLRSAYSQFIYLLGGADHEQTERMRAYLSNLCRGWNVAQVSDIVAETLHDLIDPIIYDEAASLIEDHHLAGRDVVIVSSSGAEVVEPIGELLGADRTIATRMVVEDGRYTGEIDYYAYGPAKAEAVRELAYAEGYDLARSYAYSDSITDVPLLETVGHPYAVNPDRALRREAEQRDWPVLSFAHPVRLKQRLPQFSLPSRPVLAAAAAGLAAATAAGVVWYAYRRRLQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3I9</accession>
    <name>A0A0F7N3I9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cell division protein SepF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">sepF</name>
        <name evidence="7" type="ORF">AA958_06505</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer. Interacts with FtsZ.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="5">Localizes to the division site, in a FtsZ-dependent manner.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SepF family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015270.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_06505"/>
    <dbReference type="EnsemblBacteria" id="AKH81918">
        <property type="protein sequence ID" value="AKH81918"/>
        <property type="gene ID" value="AA958_06505"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_06505"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1358"/>
    <dbReference type="OrthoDB" id="2064885at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043093">
        <property type="term" value="P:FtsZ-dependent cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01197">
        <property type="entry name" value="SepF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023052">
        <property type="entry name" value="Cell_div_SepF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007561">
        <property type="entry name" value="Cell_div_SepF/SepF-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038594">
        <property type="entry name" value="SepF-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35798">
        <property type="entry name" value="PTHR35798"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04472">
        <property type="entry name" value="SepF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 5 7" id="KW-0132">Cell division</keyword>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0717">Septation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="16"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="34"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH81918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="211" mass="23329" checksum="F53A83FE71EF3F7A" modified="2015-07-22" version="1">MAGAMRKMAVYLGLVEDDGYDGPGYDPDDEFEPEPEPERRHRHQAPQPPHQEEPPRAIASPPAQRERPTDREPAGRSPGLLPESGRSGRIAPVSSITPDRPSLEKSAPVIMPKAVSEREPYRITTLHPRTYNEARTIGEHFREGTPVIMNLTEMDDTDAKRLVDFAAGLVFGLHGSIERVTQKVFLLSPANVDVTAEDKARIAEGGFFNQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3P2</accession>
    <name>A0A0F7N3P2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADP oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_10870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015986.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_10870"/>
    <dbReference type="EnsemblBacteria" id="AKH82646">
        <property type="protein sequence ID" value="AKH82646"/>
        <property type="gene ID" value="AA958_10870"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_10870"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2286"/>
    <dbReference type="OrthoDB" id="1768241at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F420_oxidored" evidence="1">
        <location>
            <begin position="3"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="224" mass="22754" checksum="B3008526D3CD90F6" modified="2015-07-22" version="1">MNIGILGTGNMAHALASHWVRAGHHLTIGGRDTRKARHLAARLGGATTAGGLRAAVEGGQDVVLAALPFGAGVPVVRELRTALDGKVLLDCSNPVGPGFRLLTDGGPSAARLLAAAAPGARVVKAFNLCHEDVWRMRPPVFDGRPLAVPLCGDDPAALALVRELVRDIGCDPVPGGGLDRAGLLEATAALFIALWVGEGADVQAIAPPLAYAAGPGGALPPPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3S0</accession>
    <name>A0A0F7N3S0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_14945</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016615.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_14945"/>
    <dbReference type="EnsemblBacteria" id="AKH83300">
        <property type="protein sequence ID" value="AKH83300"/>
        <property type="gene ID" value="AA958_14945"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_14945"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3150"/>
    <dbReference type="OrthoDB" id="1907687at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH83300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="125" mass="13730" checksum="67C17C0850B0AF48" modified="2015-07-22" version="1">MQEEIARSAIDMFISAFNASDESYVTALLSQALTSDVVFWGPLGRSEGIEAVERFVLDIRRHPAGTGTMVRCSAVDMPDEWARYQWVFTAPDGGPRLAGTDVVHLRRSLIDQVIVFAGEIEPSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3U4</accession>
    <name>A0A0F7N3U4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_07065</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015368.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_07065"/>
    <dbReference type="EnsemblBacteria" id="AKH82018">
        <property type="protein sequence ID" value="AKH82018"/>
        <property type="gene ID" value="AA958_07065"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_07065"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1480"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013211">
        <property type="entry name" value="LVIVD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08309">
        <property type="entry name" value="LVIVD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519753" evidence="2">
        <location>
            <begin position="36"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH82018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="465" mass="49955" checksum="01FE669500C7314D" modified="2015-07-22" version="1">MTDRQGISRRGALRASLAGAAAGAAGVAAPGTAAADGGAGAAVPAGRARHVEAVGYSDLEHRPAFKMAVREKRGRWYLYTGHFWDSGWSVVDVTDPARPEVVAYVPGPENTWTLQVDLHGDTTVTALEQVFPNFGGDPAAPFEEGVLIWDIADPVRPRRLGHYRTGGTGTHRNLYPGGRYVHLAAGAPGFSGNIYVILDISDRSRPREAGRWWVPGQRDDEPAPAGPGRGEAGEVAGAGGFCCSAGHDVSLHGPPYPVGNLVYLPYGGAGLVVLDIADPARPRQVGRLSFSPPFHSRFGVHGVLPVPGRKIAFANSEDVSYGTGPAHHASIVDISDPRQPFLLSLLPVPTPPRGAGYPDFSTRGGWSGPHNINHHQHHPDVQRHDGLLHVAHFNAGLRIYDVSHPRLPREAGHFMPPEPTRRYGPMPEGALALQTEDVVVDRRGYIYITDKNQGLWILRYTGPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-10-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N432</accession>
    <name>A0A0F7N432_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_15620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH83400">
        <property type="protein sequence ID" value="AKH83400"/>
        <property type="gene ID" value="AA958_15620"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_15620"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3290"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH83400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="96" mass="10697" checksum="352010A4133EA748" modified="2015-07-22" version="1">MLVAATVSDILSPNPYDLCLLGLLSECEQPLLEQGRGDGPWVEVADLDETELVMGFPWHLERVVQHGSHRREGDLVQAGTQLRMTDLHEFLGEFPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N485</accession>
    <name>A0A0F7N485_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_04990</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015012.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_04990"/>
    <dbReference type="EnsemblBacteria" id="AKH81657">
        <property type="protein sequence ID" value="AKH81657"/>
        <property type="gene ID" value="AA958_04990"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_04990"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1049"/>
    <dbReference type="OrthoDB" id="1048863at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="15"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH81657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="280" mass="29855" checksum="BDDD4B010E01FD33" modified="2015-07-22" version="1">MADRTPDRSPEASRLAAGNVTLPYDSRVVAEHLSVAVPDASFTVVVGPDACGKPTLLRALARMLKPRTGAVLLDGEAIGTLPARKVARTLGLPPQSSVAPGGITVGDLVARGRYPHQGLLGPWSREDERAVRESMAATGVGELADRYVDELSGGQRQRVWIAMALVQQTPLLLLDEPTTYLDIQHQIDVLDLCAELHETQGRTLVAVLHDLDHAARYATHLIAMRDGRIVAEGAPNDIVDAELVERVFGLTCQVIAAPETGTPLVVPAARKARAGADGWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4G3</accession>
    <name>A0A0F7N4G3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AA958_16510</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016850.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_16510"/>
    <dbReference type="EnsemblBacteria" id="AKH83545">
        <property type="protein sequence ID" value="AKH83545"/>
        <property type="gene ID" value="AA958_16510"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_16510"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3475"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="380"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="38"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="344"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="401"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="419"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="451"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AKH83545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="547" mass="56491" checksum="B450FA4BA268E67D" modified="2015-07-22" version="1">MSQTEPPEEPSANGPGRGGMADSPENWGVGGLVGDGRYRLTRRLGRGGMAEVFAAEDVRLGREVAVKLLRSDLAEDPVSKARFTREAQSVAGLNHHAVVAVYDSGEDQVAGSTVPYIVMELVEGRTIKELLTGAEIPPPDQALLIISGVLEALAYSHQHSIVHRDIKPANVIITTTGAVKVMDFGIARALHGAASTMTQTGMVMGTPQYLSPEQALGRAVDTRSDLYAVGCLLYELLTGRPPFIGETPLAVVYQHAQDNAVPPSQISEDAPPELDGLVMRALAKEPEDRFQTADEMLGLLQYALRMLRDVGPHTGTWDTGAVAVGGTPPMGTPAVGATAATAALASAGGDTPPRMLRPSGPDDGGFDPGPRRAGRGRGRMWAIAALAVVAIVLGVAFALSGGDDENKKQAPPTPTKQEQSPTKDKEKEEDSPSPTEEEPTYHDDEPTWEETSEPPPTTSPTDSPTGTGSPTGSPSEPTDDVGGSTSEGSGGTTESGGSTTGETTGETTGETTGETTGETTGEVEGGEIGGEVVDGGQANGGAAGTEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4M2</accession>
    <name>A0A0F7N4M2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_12710</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016276.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH82941">
        <property type="protein sequence ID" value="AKH82941"/>
        <property type="gene ID" value="AA958_12710"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_12710"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2671"/>
    <dbReference type="OrthoDB" id="1437290at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="22"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH82941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="195" mass="21354" checksum="0AF0E33764364878" modified="2015-07-22" version="1">MEHGVTRRKAEPVTDGRRARGARRRAEIIEATLRVVQRDGAGGVTHRTVAREADVTTSLTAYYFATLDDLLVAALSTVADEYTRRLHEIIESDTDDLEGLAALVASAGGEGRRRALAERELSTMAARRPALRPVARRWREVVAQIGERHSTDPRAVDALVAATDGLCADILLTDARPDVRRIRAVLAHSLRTGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4N2</accession>
    <name>A0A0F7N4N2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_16925</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the tRNA methyltransferase O family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016919.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_16925"/>
    <dbReference type="EnsemblBacteria" id="AKH83615">
        <property type="protein sequence ID" value="AKH83615"/>
        <property type="gene ID" value="AA958_16925"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_16925"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3561"/>
    <dbReference type="OrthoDB" id="1535774at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd09281">
        <property type="entry name" value="UPF0066"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023370">
        <property type="entry name" value="TrmO-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040372">
        <property type="entry name" value="YaeB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036413">
        <property type="entry name" value="YaeB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036414">
        <property type="entry name" value="YaeB_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12818">
        <property type="entry name" value="PTHR12818"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01980">
        <property type="entry name" value="TrmO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118196">
        <property type="entry name" value="SSF118196"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51668">
        <property type="entry name" value="TSAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="TsaA-like" evidence="4">
        <location>
            <begin position="6"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="67"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00033753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH83615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="157" mass="17469" checksum="A2CB4A6975F98E25" modified="2015-07-22" version="1">MPSFEITPIGTVRNDRTDIQNTDNWGAVRSTITVDERFGEACLQGLEGFSHVEVVFVFDRFPEPDASAVNEPRPYRGRADLPPMGIFAGRGPRRPNRLGATTCAIESVEGRELTVVGLDAVSGTPVVDLKPAMEEFRPAEVRQPEWVSRMMSEYFKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4P8</accession>
    <name>A0A0F7N4P8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_05960</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015175.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_05960"/>
    <dbReference type="EnsemblBacteria" id="AKH81822">
        <property type="protein sequence ID" value="AKH81822"/>
        <property type="gene ID" value="AA958_05960"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_05960"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1246"/>
    <dbReference type="OrthoDB" id="1529037at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH81822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="309" mass="32840" checksum="3CF1BF4508881F87" modified="2015-07-22" version="1">MNDLPQQLANGLLLGALYGLIAIGYTMVYGIVQLINFAHGEIFMIGGFGALTMWLWMPNGTSLLVALPLMILMAVICSVLVGVGAERFAYRPLRGAPRLAPLITAIGLSIALQQAIWAWYPDATKSRPFPEFSGPRLDFGAFTIERGELYLLIAAPLCMIALGFFVSKTRTGRAMQATSQDPDTAKLMGINTDRIIVMAFAIGAAFAAIAAIAHGLRYGEVNFKMGFIAGLKAFTAAVLGGIGNIYGAMIGGVVLGLAEAMATAYIADIPGMEQLGGGAWKDVWAFVLLILVLLLRPQGLLGERVADRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N533</accession>
    <name>A0A0F7N533_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Daunorubicin resistance protein DrrC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_10055</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015855.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_10055"/>
    <dbReference type="EnsemblBacteria" id="AKH82513">
        <property type="protein sequence ID" value="AKH82513"/>
        <property type="gene ID" value="AA958_10055"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_10055"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2117"/>
    <dbReference type="OrthoDB" id="152379at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="2">
        <location>
            <begin position="150"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="2">
        <location>
            <begin position="482"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="522"/>
            <end position="529"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH82513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="794" mass="84290" checksum="696BDA656A427866" modified="2015-07-22" version="1">MATRKDTPAPEQHAADSHDLIRVHGARENNLRNVDVEIPKRRLTVFTGVSGSGKSSLVFDTIAAESQRMINETYSTFVQGFMPTLARPDVDVLEGLTTAIIVDQERMGANARSTVGTATDANALLRILFSRLGEPHVGPPNAFSFNVASAQGTGAVTVDRGAGETVKEVAFTSTGGMCPRCEGMGSISDIDLSELYDETKSLSEGAITIPGYKAGGWMVRLYAESGFFDPDKPIGKFTDKELHDFLHHEQTKLKVSGMNVTYEGLVPRVQKSFLSKDRESMQPHIRAFVDRIATFTACPECEGTRLSAAARSSKVAGISIADACAMQINDLAEWARALDEPSVAPLLKTLRETLDSFVEIGLGYLSLDRPSGTLSGGEAQRTKMIRHLGSSLTDTTYVFDEPTTGLHPHDIRRMNDLLLRLRDKGNTVMVVEHKSEVISIADHIVDLGPGAGTAGGTVCYEGTVDGLRAAGTVTGRHLDDRAGLKDTVRKATGALEIRGASTHNLQNVDVDIPLGVLCVVTGVAGSGKSSLVHSSLPAGAGVVSVDQGAIRGSRRSNPATYTGLLDPIRKAFANANGVKPALFSANSEGACPACKGAGVIYTDLGIMAGVSTTCEECDGKRFQASVLDYRFGGRDISEVLAMPVAEAEEFFAGGEARTPAAHRILRRLTDVGLGYVSIGQPLTTLSGGERQRLKLATHMGDKGGIYVLDEPTTGLHLADVEQLLGLLDRLVDGGKSVIVIEHHQAVMAHADWIVDLGPGAGHDGGRVVFEGTPADLVADRSTLTGEHLAEYVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5A7</accession>
    <name>A0A0F7N5A7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Type III pantothenate kinase</fullName>
            <ecNumber evidence="6">2.7.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">PanK-III</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Pantothenic acid kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">coaX</name>
        <name evidence="7" type="ORF">AA958_18235</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>(R)-pantothenate + ATP = (R)-4'-phosphopantothenate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16373"/>
            <dbReference type="ChEBI" id="CHEBI:10986"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29032"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.33"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>NH4(+)</name>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
        </cofactor>
        <cofactor evidence="6">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="6">A monovalent cation. Ammonium or potassium.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 6">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the type III pantothenate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.33" evidence="6"/>
    <dbReference type="EMBL" id="CP011492">
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    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_18235"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3834"/>
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    </dbReference>
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        <property type="entry name" value="Type_III_PanK"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="baf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="5 6" id="KW-0173">Coenzyme A biosynthesis</keyword>
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    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0630">Potassium</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="112"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="114"/>
        </location>
    </feature>
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        <location>
            <begin position="6"/>
            <end position="13"/>
        </location>
        <ligand>
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        </ligand>
    </feature>
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        <location>
            <position position="134"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:60242"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="137"/>
        </location>
        <ligand>
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        </ligand>
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            <position position="189"/>
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        <ligand>
            <name>substrate</name>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH83825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="265" mass="28120" checksum="6A12AD43DF64EDD7" modified="2015-07-22" version="1">MLLTIDVGNTHTVLGLFDGEEIVEHWRISTDARRTADELAVLLQGLMGMHPLLGEELGDGIHGIAICSTVPSVLHELREVTRRYYGDVPSVLVEPGVKTGVPVLMDNPKEVGADRIINALAAAELYGGPAIVVDFGTATTFDAVSERGEYVGGVIAPGIEISTEALGVRGAQLRKIELARPRSVIGKNTVEAMQSGILYGFAGQVDGVVNRMAAELADDPDEVTVIATGGLAPMMLADSSVIDEHEPWLTLIGLRLVYARNVSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5I1</accession>
    <name>A0A0F7N5I1_9ACTN</name>
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            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
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    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
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                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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        <property type="gene ID" value="AA958_15140"/>
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        <source>
            <dbReference type="EMBL" id="AKH83331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="94" mass="10200" checksum="0FCFF81A0FA49EF6" modified="2015-07-22" version="1">MATTTIQVTREVRDHLAELAKERGVSLGQLVEALAAEQPTAAQRAERLAADREVARRLIGVDLSDEEFDQAPDVLGNIYKMAAEKARAARDAVA</sequence>
</entry>
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    <accession>A0A0F7N6G4</accession>
    <name>A0A0F7N6G4_9ACTN</name>
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        <submittedName>
            <fullName evidence="3">Glyoxalase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_20855</name>
    </gene>
    <organism evidence="3 4">
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        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
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            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH84235">
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        <property type="gene ID" value="AA958_20855"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_20855"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4396"/>
    <dbReference type="OrthoDB" id="1900922at2"/>
    <dbReference type="Proteomes" id="UP000034283">
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    </dbReference>
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    </dbReference>
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    <dbReference type="InterPro" id="IPR037523">
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    </dbReference>
    <dbReference type="Pfam" id="PF00903">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
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    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="5"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH84235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="120" mass="12637" checksum="A31676A9A4434279" modified="2015-07-22" version="1">MNITHAQFVTLPVADQDRAKTFYTDALGFDVVADRQMGPVRWLAVAPEGAQTHFVLAAAEQGFTPGSVHGTALVSADLDGDCAALRAAGAKVEGPDDQPWGRQATLEDPDGNRFVLSAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6H0</accession>
    <name>A0A0F7N6H0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_12700</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016274.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH82939">
        <property type="protein sequence ID" value="AKH82939"/>
        <property type="gene ID" value="AA958_12700"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_12700"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2669"/>
    <dbReference type="OrthoDB" id="1570162at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004111">
        <property type="entry name" value="Repressor_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02909">
        <property type="entry name" value="TetR_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="32"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="10"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH82939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="243" mass="26763" checksum="932CBB58A8C72193" modified="2015-07-22" version="1">MPGQRDRRQPAATPADRTDRTDRPGRTGRPRSTSRAEILAAARRVIDQDGWETLTVRRLAAEIGVGTTTLYHHVHNKDDLVVELVNQHLDQLARPELPDDPRERIVVAATTMHDALTNWPWAAEALTADGFIGRLGDSALWIVETIVAGAVAAGATQEQAVDVFRSIWYYTVGEVLVRARSDRRRADVGTADLAYGLRRLDPSRQPQLAAIGDLWPERSAVDLYPQVLRIIVDGLLAAAGRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6N8</accession>
    <name>A0A0F7N6N8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">30S ribosomal protein S8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpsH</name>
        <name evidence="6" type="ORF">AA958_21245</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uS8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018834834.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_21245"/>
    <dbReference type="EnsemblBacteria" id="AKH84300">
        <property type="protein sequence ID" value="AKH84300"/>
        <property type="gene ID" value="AA958_21245"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_21245"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4474"/>
    <dbReference type="OrthoDB" id="1692188at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01302_B">
        <property type="entry name" value="Ribosomal_S8_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000630">
        <property type="entry name" value="Ribosomal_S8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035987">
        <property type="entry name" value="Ribosomal_S8_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11758">
        <property type="entry name" value="PTHR11758"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00410">
        <property type="entry name" value="Ribosomal_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56047">
        <property type="entry name" value="SSF56047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH84300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="132" mass="14401" checksum="02B4B88EEBF291BB" modified="2015-07-22" version="1">MTMTDPIADMLTRLRNANSAYHDTVTMPHSKIKTHIAEILQQEGYISGWKTEEARVGQSLVLELKYGPNRERSIAGIKRISKPGLRVYAKSTNLPKVLGGLGVAIISTSHGLLTDKQAGKKGVGGEVLAYVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6P0</accession>
    <name>A0A0F7N6P0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Citrate synthase (unknown stereospecificity)</fullName>
            <ecNumber evidence="3">2.3.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_13120</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Carbohydrate metabolism; tricarboxylic acid cycle.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the citrate synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.16" evidence="3"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016346.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_13120"/>
    <dbReference type="EnsemblBacteria" id="AKH83014">
        <property type="protein sequence ID" value="AKH83014"/>
        <property type="gene ID" value="AA958_13120"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_13120"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2761"/>
    <dbReference type="OrthoDB" id="1412360at2"/>
    <dbReference type="UniPathway" id="UPA00223"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036440">
        <property type="term" value="F:citrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019810">
        <property type="entry name" value="Citrate_synthase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739">
        <property type="entry name" value="PTHR11739"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00143">
        <property type="entry name" value="CITRTSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="SSF48256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00480">
        <property type="entry name" value="CITRATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="348"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH83014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="368" mass="39802" checksum="6F739DD46C097F6F" modified="2015-07-22" version="1">MSDFVPGLEGVVAFETEIAEPDKEGGALRYRGVDIEDLVGHVSFGNVWGLLVDGAFKPGLPPAEPFPIPVHSGDIRVDVQSALAMLAPVWGLRPLLDIDEARAREDLARAAVMALSYVAQSARGQGRPMVPQREIDKARTVVERFMIRWRGEPDPKHVAAVDAYWTSAAEHGMNASTFTARVIASTGADVAAALSGAVGAMSGPLHGGAPSRVLGMIEEIERTGDAEGYVKRALDNGERLMGFGHRVYRAEDPRARVLRRTAKQLGAPRYEVAEALEKAALAELRARRPDRVLETNVEFWAAIVLDFAEVPAHMFTSMFTCARTAGWSAHILEQKRTGRLVRPSARYVGPGTRSPQEIEGYAEAGGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N847</accession>
    <name>A0A0F7N847_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_16940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016922.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_16940"/>
    <dbReference type="EnsemblBacteria" id="AKH83618">
        <property type="protein sequence ID" value="AKH83618"/>
        <property type="gene ID" value="AA958_16940"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_16940"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3564"/>
    <dbReference type="OrthoDB" id="1736098at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13577">
        <property type="entry name" value="SnoaL_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="10"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="144" mass="15922" checksum="9843E10D7A5BC901" modified="2015-07-22" version="1">MPGTETLIRDLADRAALADLVARHSLWIDEGRFDETDRLFTPDVVVRSPRGEAHGIEALVGLARGGHDTYVRTLHTKSNLVIVIDGRTATVRAHDVAVFVLDDKTEAIAAAIHRYGARRTEDGWRFDRLDVTPVALTEALDRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8C8</accession>
    <name>A0A0F7N8C8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ESAT-6-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_13085</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WXG100 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_026276583.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_13085"/>
    <dbReference type="EnsemblBacteria" id="AKH83007">
        <property type="protein sequence ID" value="AKH83007"/>
        <property type="gene ID" value="AA958_13085"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_13085"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2753"/>
    <dbReference type="OrthoDB" id="1938082at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036689">
        <property type="entry name" value="ESAT-6-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010310">
        <property type="entry name" value="T7SS_ESAT-6-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06013">
        <property type="entry name" value="WXG100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140453">
        <property type="entry name" value="SSF140453"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03930">
        <property type="entry name" value="WXG100_ESAT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="10"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU362001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH83007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="100" mass="11264" checksum="7BE3C7A358F39AEF" modified="2015-07-22" version="1">MGKADVDVTYQDMRDAAKRLKDERQDIDRKLDDLRKYIQSLVSDGYVTGRSSKQFDQSFDEFTTGAKKTIEGLEGMGDFLKSAAEAFENLDSELEKGLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8G0</accession>
    <name>A0A0F7N8G0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_13220</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016364.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_13220"/>
    <dbReference type="EnsemblBacteria" id="AKH83032">
        <property type="protein sequence ID" value="AKH83032"/>
        <property type="gene ID" value="AA958_13220"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_13220"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2782"/>
    <dbReference type="OrthoDB" id="558559at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904823">
        <property type="term" value="P:purine nucleobase transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045018">
        <property type="entry name" value="Azg-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43337">
        <property type="entry name" value="PTHR43337"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="83"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="287"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="366"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="394"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="426"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="460"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH83032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="489" mass="50660" checksum="F9E15AAFF9A1A2A3" modified="2015-07-22" version="1">MPPDAKTTGTAPGDGPPPRPSSPLDAYFHISRRGSSVTQELRGGLATFFAMAYIIVLNPIILGSAKDKFGHKLDHGELVTATVLVAAVTTLLMGVLGNVPVACAAGLGINAVVSLQLAPEMSWPDAMGMVVLAGLIIMLLVATGLRERVMSAIPDGLRKAIAIGIGLFIALVGLVDAGLVTRNPDSAQTTVPLTLGTAGHLKGWPVLVFLLGLGLTFVLLARRFRGAILVSIVTMTVLAVIIHAVADLPEKEWGLTAPVLPGHVVEAPHFGLLGEASLFGGFREAGILTGCLFVFTVLLSGFFDAMGTILGVTEEARLLDEHGRLPEMNRVLMADGAAVALGGAASASASTAFAESTAGVGEGARTGLANLVTGGLFLLALVFTPLVTIVPSQAATPALVVVGFLILSATIRSIDWSDTTIAAPAFLTIVLMPFSYSITVGIGMGFLAHTLLRTAVGRPASVRPALWVTSAVFVVYFALEPIERWLGLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8W6</accession>
    <name>A0A0F7N8W6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_25290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018226.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_25290"/>
    <dbReference type="EnsemblBacteria" id="AKH84975">
        <property type="protein sequence ID" value="AKH84975"/>
        <property type="gene ID" value="AA958_25290"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_25290"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5330"/>
    <dbReference type="OrthoDB" id="1923580at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039708">
        <property type="entry name" value="MT1774/Rv1733c-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42305">
        <property type="entry name" value="PTHR42305"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="207" mass="22377" checksum="6663CF0B278BE4FD" modified="2015-07-22" version="1">MAAGAGMGREEDRPVRRVWSRRNPFRRRTDVLEGWVTFGAVAVFALGGTAAAWASAAAVHEELSSRSAERQRTTAVLLEDAPPLTMLRGDAWAGGEVATKVRWRDADGRAHTGRTRVSAGLRRGAEAEIWTDASGRHAVDPPPPPGDTGVQSAVAAGGAAGVVGCLVFGSRTVVRVRLDRRRAEEWERDWARVEPYWRQGSAGPSER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8Z1</accession>
    <name>A0A0F7N8Z1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Anti-sigma factor antagonist</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_14320</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the anti-sigma-factor antagonist family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018835875.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_14320"/>
    <dbReference type="EnsemblBacteria" id="AKH83212">
        <property type="protein sequence ID" value="AKH83212"/>
        <property type="gene ID" value="AA958_14320"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_14320"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3014"/>
    <dbReference type="OrthoDB" id="1864829at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043856">
        <property type="term" value="F:anti-sigma factor antagonist activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003658">
        <property type="entry name" value="Anti-sigma_ant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00377">
        <property type="entry name" value="ant_ant_sig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="3">
        <location>
            <begin position="3"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH83212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="113" mass="12449" checksum="E8314FB06F8C9CB2" modified="2015-07-22" version="1">MDLSLSTRTVGDRTVVEVGGEIDVYTAPKLREQLVELVNDGSYHLVVDMERVDFLDSTGLGVLVGGLKRVRAHEGSLRLVCNQERILKIFRITGLTKVFPIHTSVDEAVAAKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9H3</accession>
    <name>A0A0F7N9H3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cold-shock protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_20545</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018840208.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_20545"/>
    <dbReference type="EnsemblBacteria" id="AKH84178">
        <property type="protein sequence ID" value="AKH84178"/>
        <property type="gene ID" value="AA958_20545"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_20545"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4334"/>
    <dbReference type="OrthoDB" id="2034748at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012156">
        <property type="entry name" value="Cold_shock_CspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019844">
        <property type="entry name" value="CSD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002599">
        <property type="entry name" value="Cold_shock_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00050">
        <property type="entry name" value="COLDSHOCK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00352">
        <property type="entry name" value="CSD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="3">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH84178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="67" mass="7145" checksum="0031F3E2D65C019D" modified="2015-07-22" version="1">MATGTVKWFNAEKGFGFIAQDGGGPDVFVHYTAINAQGFRSLEENQQVTFDVQQGPKGPQAANVSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NA00</accession>
    <name>A0A0F7NA00_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Translation initiation factor IF-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">infA</name>
        <name evidence="5" type="ORF">AA958_21290</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IF-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003948620.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A0F7NA00"/>
    <dbReference type="STRING" id="444103.AA958_21290"/>
    <dbReference type="EnsemblBacteria" id="AKH84309">
        <property type="protein sequence ID" value="AKH84309"/>
        <property type="gene ID" value="AA958_21290"/>
    </dbReference>
    <dbReference type="GeneID" id="58470379"/>
    <dbReference type="GeneID" id="67399256"/>
    <dbReference type="KEGG" id="strc:AA958_21290"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4483"/>
    <dbReference type="OrthoDB" id="2066663at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04451">
        <property type="entry name" value="S1_IF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00075">
        <property type="entry name" value="IF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006196">
        <property type="entry name" value="RNA-binding_domain_S1_IF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004368">
        <property type="entry name" value="TIF_IF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33370">
        <property type="entry name" value="PTHR33370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01176">
        <property type="entry name" value="eIF-1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00008">
        <property type="entry name" value="infA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50832">
        <property type="entry name" value="S1_IF1_TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2 3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="2 3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="S1-like" evidence="4">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH84309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="73" mass="8411" checksum="C17FB7C2DD0D7912" modified="2015-07-22" version="1">MAKKQGAIEIEGTVVESLPNAMFKVELQNGHQVLAHISGKMRMHYIRILPDDRVVVELSPYDLTRGRIVYRYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAI7</accession>
    <name>A0A0F7NAI7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA primase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_25880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018324.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_25880"/>
    <dbReference type="EnsemblBacteria" id="AKH85081">
        <property type="protein sequence ID" value="AKH85081"/>
        <property type="gene ID" value="AA958_25880"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_25880"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5450"/>
    <dbReference type="OrthoDB" id="1601056at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015330">
        <property type="entry name" value="DNA_primase/pol_bifunc_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09250">
        <property type="entry name" value="Prim-Pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00943">
        <property type="entry name" value="Prim-Pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prim-Pol" evidence="1">
        <location>
            <begin position="31"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="229" mass="23696" checksum="22F6089E4BB66ECA" modified="2015-07-22" version="1">MGFPIGGIRGRRDIGSVRRARTSAGHAATAVAEYTGLWGWDVLPGAPLVRGDGGGRVCSCARGAACPAPGEHPLPDARPVPAGTPLDEVTDAWAGTPGAAVLLPVGLSFDALEVSAVAGRRALPRLERLGLPLGPVSATPDGRAHFFVAPGAAAELPRLLYRMGWDGARLDLRCLGRGDYMLAPPCDLRGLGPVRWLRPPTLDTAGGPPPARLLLGTLAYAQSAWLRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAI9</accession>
    <name>A0A0F7NAI9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Fe-S oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_17585</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017021.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_17585"/>
    <dbReference type="EnsemblBacteria" id="AKH83717">
        <property type="protein sequence ID" value="AKH83717"/>
        <property type="gene ID" value="AA958_17585"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_17585"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3702"/>
    <dbReference type="OrthoDB" id="1951488at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004017">
        <property type="entry name" value="Cys_rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02754">
        <property type="entry name" value="CCG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13183">
        <property type="entry name" value="Fer4_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="6">
        <location>
            <begin position="298"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="6">
        <location>
            <begin position="386"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="740"/>
            <end position="766"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH83717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="766" mass="83500" checksum="3C4D61594B890879" modified="2015-07-22" version="1">MQLAAIVVSLVITAVGTALFARAIGQIIAFVRLGKPVPAGSRTDDPVARSTTLAREFLGHTRMNRWGVIGIAHWFVAIGFLTLVLTLVNAFGQLFVADWLLPVIGEWLPYELYVEFIALMTTLGILTLIVIRQLSLPSKAGRKSRFTGSTMWQAYFVEYVILVIGICILVLRGLEGSLHHIGGYEAAYFASYPVTAAVDGLSTGAVQNLVYLFAMIKISTSFIWALVLGLNATMGVAWHRFLAFPNIWFKRNADGAVALGALQPMTSGGKPIDFETVFDDEDGEETVFGVSQVEHFSWKGILDFSTCTECGRCQSQCPAWNTGKPLSPKLLVMSLREHAAAKAPYLLAGGGKSAEGEEKATAEQLADVPAGALAEAERALIGTAAEQGVIDPDVLWSCTTCGACVEQCPVDIEHVDHIVDMRRYQVMIESSFPSEAGTMLKNLEKKGNPWGLAKKQRLEWTKELAADTGIEIPVVGRDVEDLSEVDYLYWVGCAGALEDRAKKTTKAFAELLHIAGVKFAIMGGDEKCTGDSPRRLGNEFLFQQLGEENVAMLNMAFGEDPDEGVTVEKAKKKIVATCPHCFNTIANEYPQLGGHYEVIHHTQLLQHLVDEGRLVPVTPVEGIITYHDPCYLGRHNKVYTPPREIIAKVPGVRNEEMHRHKERGFCCGAGGARMWMEERIGKRINDERVDEALSLNPDILSTACPFCLVMLTDSVNGKKNAGTAKESLAVVDVAQLLLDSVRTPAQEPPGDGTEAAESEPEPQPAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-10-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAY3</accession>
    <name>A0A0F7NAY3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_27090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH85291">
        <property type="protein sequence ID" value="AKH85291"/>
        <property type="gene ID" value="AA958_27090"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_27090"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5707"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH85291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="64" mass="7153" checksum="6478F0E9845AA8ED" modified="2015-07-22" version="1">MWRIEWGLGLLAVVLAVTGIFTETVWVLGVGAWMLIAACLIDMVYRPCQQTPHTSTRSPTVRVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NB17</accession>
    <name>A0A0F7NB17_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">Multifunctional fusion protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="9">Protein translocase subunit SecD</fullName>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="10">Protein-export membrane protein SecF</fullName>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="9" type="primary">secD</name>
        <name evidence="10" type="synonym">secF</name>
        <name evidence="13" type="ORF">AA958_27295</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the SecD/SecF family. SecD subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the SecD/SecF family. SecF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018556.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_27295"/>
    <dbReference type="EnsemblBacteria" id="AKH85321">
        <property type="protein sequence ID" value="AKH85321"/>
        <property type="gene ID" value="AA958_27295"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_27295"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5751"/>
    <dbReference type="OrthoDB" id="410730at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015450">
        <property type="term" value="F:protein-transporting ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043952">
        <property type="term" value="P:protein transport by the Sec complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01463_B">
        <property type="entry name" value="SecD_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01464_B">
        <property type="entry name" value="SecF_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005791">
        <property type="entry name" value="SecD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022813">
        <property type="entry name" value="SecD/SecF_arch_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022645">
        <property type="entry name" value="SecD/SecF_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022646">
        <property type="entry name" value="SecD/SecF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005665">
        <property type="entry name" value="SecF_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30081">
        <property type="entry name" value="PTHR30081"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07549">
        <property type="entry name" value="Sec_GG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02355">
        <property type="entry name" value="SecD_SecF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01755">
        <property type="entry name" value="SECFTRNLCASE"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00916">
        <property type="entry name" value="2A0604s01"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00966">
        <property type="entry name" value="3a0501s07"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01129">
        <property type="entry name" value="secD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="7 9" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519263" description="Multifunctional fusion protein" evidence="12">
        <location>
            <begin position="24"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="291"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="316"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="389"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="417"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="483"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="595"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="620"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="647"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="689"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="723"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="122"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AKH85321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="755" mass="77880" checksum="7FEF22E04177881C" modified="2015-07-22" version="1">MTRATRVRAVLALAVLALSVAVAVLVPVHLGLDLRGGTQIVLEARDSDAAKADADTTDHTLEVLRNRVDALGVTEPTLTRSGEDRIIVDLPGVQDPREAADLLGRTAQLTFHPVLGLADGTAADGKGADGKGTDGKGTDGEEADGKVLRDEAGQPLRLGPAALTGADVADAEALFDTQQARGWFVTVGFDGDGGSGWAGLTGAAACAPPGDQARRIAIVLDGKVISSPQVDPGVGCRTGITGGSTQITGDFGRDEARELALLVNGGALPMPLETVEQRTVGPTLGADAISASAWAALIGAALTSVFIIVVYRLLGLLATVALACYALISYAALAALGATLTLPGLAGFVLAIGMAVDANVLVFERAREEYAAGRRPTVRTALAGGFRKAFSAIADSNVTTLIAAGLLFLLASGPVRGFGVTLAIGVLASMFSALVVTRVLAEYAAGRRALRVRPGRSGIAGHGRVRAWLVRRDPKLMRHSRRWLALSGVALLLAGSGIVARGLDFGVEFTGGRLIEYATTQPVDADDARAALADAGQPRAVVNTSGDSELTVRTEELSDDEAAEVTAAVDELGGGAEMVRDEMIGPSLGEELRTGAFIALGVVLAAQLVYLAVRFRWTYATSAVAALVHDAVILVGVFAWLGKPIDGVFLAALLTVIGYSVNDSVVLYDRVRELVAADRRKPFRTAANTAILQTLPRTVNTGMGAVFILAALALLGGGALTDFALALLVGIAAGTYSSVFTATPLAIELDAGRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NB20</accession>
    <name>A0A0F7NB20_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Zinc finger CDGSH-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_29590</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018929.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_29590"/>
    <dbReference type="EnsemblBacteria" id="AKH85700">
        <property type="protein sequence ID" value="AKH85700"/>
        <property type="gene ID" value="AA958_29590"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_29590"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6245"/>
    <dbReference type="OrthoDB" id="2002590at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043231">
        <property type="term" value="C:intracellular membrane-bounded organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018967">
        <property type="entry name" value="FeS-contain_CDGSH-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042216">
        <property type="entry name" value="MitoNEET_CISD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09360">
        <property type="entry name" value="zf-CDGSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00704">
        <property type="entry name" value="ZnF_CDGSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ZnF_CDGSH" evidence="3">
        <location>
            <begin position="23"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH85700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="67" mass="7637" checksum="248D3B91A651BC6A" modified="2015-07-22" version="1">MHSARDESPCRLRVQRTGPLLIEGPVEVMLDDGTVADSDRFTVAVCTCRRSRTYPWCDTSHRRRTGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBB1</accession>
    <name>A0A0F7NBB1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_19380</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017282.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_19380"/>
    <dbReference type="EnsemblBacteria" id="AKH83987">
        <property type="protein sequence ID" value="AKH83987"/>
        <property type="gene ID" value="AA958_19380"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_19380"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4074"/>
    <dbReference type="OrthoDB" id="710201at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="9"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH83987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="438" mass="48809" checksum="A39981D0140492D8" modified="2015-07-22" version="1">MDDEIRHPLAHARIERGWPQEELARRIRRAAKRRGLRSGTRGSRVSKWETGRATPDEDESQPLIAEVLGIDYAAVTHLGWPHWLPGQDRPLPLGPHNAVPSLREALMSSLDRRSFIAYTSGSLAVLAYQWAVTEPGQFTRFAAPGEVDAEMLDWLEATGTELIRLATERRHRTRHLLAAHLTTVTEFISESRYTLAGGQRLHTLAASLSQAIAWQHFDERRHASAGRFWHAALHNARTGHQRDLGAGILSDLAYQLLWLGDARAAADILEHAIPRTQHPTARSLLHLRQARAFAALDEGGLCRRALTDAEKALDTPSYDPAPAWCSWMSTADLAADGGRCLADLGQRRRAHQLMDEGITLLTPTRSKTKSVFLTYQAETYLRDGEPEIAVATATRSFDLASRIGAPRCVTMVRDLEPELSRHLHTPGVSELLQRLRAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBC0</accession>
    <name>A0A0F7NBC0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_30340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019033.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_30340"/>
    <dbReference type="EnsemblBacteria" id="AKH85805">
        <property type="protein sequence ID" value="AKH85805"/>
        <property type="gene ID" value="AA958_30340"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_30340"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6410"/>
    <dbReference type="OrthoDB" id="867226at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="5"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="495" mass="53821" checksum="4EFB5E291A8CC1F1" modified="2015-07-22" version="1">MTKGVIVVGAGPVGLMLAGELRLGGVEVTVYDRLPGPSGESRGVGFTRRAAEVFDQRGLLERFGDVEWAQGHFGGVRIDFGKLADNHFSVRGIPQFRTEEILERWLGELGVPVLRRHEVHGFRETADGVVVEWEGPGGRGEDFARYLVGCDGARSLVRRLAGIDFVGWDATRGMYMADLVGAGIRQRPIGEKVAGGMVMAFNLENGVDRIVIHDEKLRPPEDKSALRFTEIADAWQRMTGESLHHAEVRWISSFTDTTRQAEHYRSGRIFLVGDATHIHMPAGAQGMSVGVQDAANLGWKLAAAVNGWAPEGLLDTFESERHPVGRDLMRNTRAQTQLYLTDDTMEPLRAVMRELVELPGVARHLAGMVSGVDIRYDSGPGDHPLLGLRMPPDVALLLPDGTRRRIADLLRTARGVLVLTDRSALPRDVAAAWSDRVDTVTGSWADDADGPSGKAPEAVLLRPDGHVAWAAPDSVSPQQAVERWFGAPGVVAGQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBC5</accession>
    <name>A0A0F7NBC5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-hydroxyacyl-CoA dehydrogenase</fullName>
            <ecNumber evidence="2">1.1.1.35</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AA958_27830</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:22432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57318"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="1.1.1.35"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.35" evidence="2"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018645.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_27830"/>
    <dbReference type="EnsemblBacteria" id="AKH85411">
        <property type="protein sequence ID" value="AKH85411"/>
        <property type="gene ID" value="AA958_27830"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_27830"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5866"/>
    <dbReference type="OrthoDB" id="977512at2"/>
    <dbReference type="UniPathway" id="UPA00659"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003857">
        <property type="term" value="F:3-hydroxyacyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3HCDH_N" evidence="9">
        <location>
            <begin position="341"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="3HCDH" evidence="8">
        <location>
            <begin position="525"/>
            <end position="605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AKH85411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="710" mass="75101" checksum="7D2BF4B663D4CDB7" modified="2015-07-22" version="1">MSSNTAELLKGAAGRFPDEVVTEAHVRHLDLPGGAGRFALITLDNGFDHTKPTTFGPQSLAGLDAALDQVEKEAAEGAIVGVGVTGKPFIFAVGADLKGVEVLGRRDEALAIGRGGHEVFKRLADLGVPTFAYYNGAAMGGGVEIGLHCTYRTVSTAVPAFSLPEVFLGLVPGWGGCTLLPNLIGADRAVTVVIENSLNQNRQLKGKQVYDLGIADAIFEGADFLEQSLAWTAAVLGGELEVVRPDIDRGEAWDAAIERGRAVADDKVHGAAPAAYRALDIMAAAKNGDLRQGFAAEDEALADLIMGGELRAGIYAFNLVQRRAKRPAGAPDKSLARPVTKVGVVGAGLMASQLALLFVRRLEVPVVLTDIDQERIDKGVAWVHEQIDMLLLKGRVNQDAANRLKALVTGSMDKTAAFADADFVIEAVFEELSLKQRIFAELEEVVPPTAILATNTSSLSVTEMAAGLRHPERVVGFHFFNPVAVLPLLEIVRAADTDDASLATAFAVAKKLKKSAVLVKDAPAFVVNRILTRFMGEVLGAVDEGTPVEVADGALAPLGLPMSPIVLLDLVGPAVAHHVAGTLAAAFPDRFAQSANLGRVVEAGKRTLYVHDSGKPELDPEVAALFQVGETALTEEQVRDRALDAIAQEIRLMLDEGVVAEAQDIDLCLITGAGWPFHLGGITPYLDREGVSERVTGRRFLPPGVASVPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-12-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBH9</accession>
    <name>A0A0F7NBH9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LacI family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_19860</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017352.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH84062">
        <property type="protein sequence ID" value="AKH84062"/>
        <property type="gene ID" value="AA958_19860"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_19860"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4185"/>
    <dbReference type="OrthoDB" id="1796334at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001761">
        <property type="entry name" value="Peripla_BP/Lac1_sug-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00532">
        <property type="entry name" value="Peripla_BP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00036">
        <property type="entry name" value="HTHLACI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="2"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH84062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="340" mass="36342" checksum="028FD66D47881EDE" modified="2015-07-22" version="1">MTTINDVARAAGVSPATVSRVFNGGRVTAERAERVRKTAAELGFSPNRVARSLRMQRASVIGLIIPDIENPFFTSLARGVEDAAQQTNLSVVLCNTDEDVDKERRYLEIAAAEQMAGVIVAAASRNRTDLSVLEGRGMPVVAVDRRPRGASVDAVMVDNQHGGEEATAHLLRSGYRRIACIAGPEGASTSDDRLAGYRAVMRDHLRETDGGTLPPEYVRHADFRVEGGRAAMRDLLALPSPPDAVFVANNLMTVGALQALREAGTEPPRTGVLSFGDVPWASLVRPPLSTVQLPSYDLGWTAAGLLQERIAGTERPLQTVVLRTALQVRESTSGPGTEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBQ3</accession>
    <name>A0A0F7NBQ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">N-acetylmuramoyl-L-alanine amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_24560</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018106.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_24560"/>
    <dbReference type="EnsemblBacteria" id="AKH84854">
        <property type="protein sequence ID" value="AKH84854"/>
        <property type="gene ID" value="AA958_24560"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_24560"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5175"/>
    <dbReference type="OrthoDB" id="1584918at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06583">
        <property type="entry name" value="PGRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.101.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036505">
        <property type="entry name" value="Amidase/PGRP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002502">
        <property type="entry name" value="Amidase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036366">
        <property type="entry name" value="PGBDSf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015510">
        <property type="entry name" value="PGRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006619">
        <property type="entry name" value="PGRP_domain_met/bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11022">
        <property type="entry name" value="PTHR11022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00701">
        <property type="entry name" value="PGRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="SSF47090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55846">
        <property type="entry name" value="SSF55846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGRP" evidence="3">
        <location>
            <begin position="2"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH84854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="248" mass="26219" checksum="20B55D8617CB68DC" modified="2015-07-22" version="1">MTTFVSRSAWGARAPRNTNSNITPQNGGVTIHHVDAVHVARANHADCAAQVRGIQNHHMDGNGWADIAYSHLVCVHDYVFQGRGENRRTAANGTDPGNQNWYAVCGLVGGTAGDYDTITSGLINAFRYAVNRLRTQGGAARAICGHRDHLSTGCPGNLYVNGVLNGATNPGGGPLPHPGVNFRQPPTFSHASVATWQNQMNARHGYSLTADGAYGPNSYAACRDFQAKKGLTVDGIVGPATWGATFPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBS0</accession>
    <name>A0A0F7NBS0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CBS domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_29115</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018860.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_29115"/>
    <dbReference type="EnsemblBacteria" id="AKH85631">
        <property type="protein sequence ID" value="AKH85631"/>
        <property type="gene ID" value="AA958_29115"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_29115"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6136"/>
    <dbReference type="OrthoDB" id="2014094at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007055">
        <property type="entry name" value="BON_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017080">
        <property type="entry name" value="UCP036990_CBS_BON"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04972">
        <property type="entry name" value="BON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036990">
        <property type="entry name" value="UCP036990_CBS_BON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50914">
        <property type="entry name" value="BON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="3">
        <location>
            <begin position="10"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="3">
        <location>
            <begin position="98"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="BON" evidence="2">
        <location>
            <begin position="151"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH85631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="243" mass="27399" checksum="ECD33DE6BB38ED2F" modified="2015-07-22" version="1">MKHRKIGNVMTDDVVTAGPATPFKEVARRLHEHRISGLPVVDDDEQVLGVISETDLMLRQAAQRPVYGPQRRRRLPRLTRRARTERRKARATDAQALMSRPAVTVRADDTVTHAARIMAAHRVERLPVVDEENRLIGIVTRRDLLQVFVRSDAEIRREVLDEVLVRGLWVVAGQVRVVVEEGIVVLEGELERQSEAAIAGTLTEKVDGVVGVVNRLTARVDDSRIRPVEQVPHGVAEDWLRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBX3</accession>
    <name>A0A0F7NBX3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AA958_31315</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019188.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_31315"/>
    <dbReference type="EnsemblBacteria" id="AKH85960">
        <property type="protein sequence ID" value="AKH85960"/>
        <property type="gene ID" value="AA958_31315"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_31315"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6617"/>
    <dbReference type="OrthoDB" id="923655at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04077">
        <property type="entry name" value="Peptidases_S8_PCSK9_ProteinaseK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034193">
        <property type="entry name" value="PCSK9_ProteinaseK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010259">
        <property type="entry name" value="S8pro/Inhibitor_I9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037045">
        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05922">
        <property type="entry name" value="Inhibitor_I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 9" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519284" evidence="6">
        <location>
            <begin position="41"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="Inhibitor I9" evidence="8">
        <location>
            <begin position="58"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S8" evidence="7">
        <location>
            <begin position="164"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH85960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="410" mass="41987" checksum="C168A304EFB2A7EC" modified="2015-07-22" version="1">MHEMRLTPTPLRRAATVLTALGLAAGLQLAAGTGANSAPADGDLRLAPAATAVDGQWIVVLKNGEVAKVDTRSVARDLAGTADVRPEHVFRTALRGFSAEMSKAEAAEVARDPRVAYVEQDAVVRTAETQANATWGLDRIDQRDLPLSTTYTYNTTAANVTAYIIDTGIRTTHSEFGGRASVGTDTVGGGQNGQDCNGHGTHVAGTVGGKTYGVAKQAKLVAVRVLNCSGSGTTAGVVAGIDWVTANATSPSVANMSLGGGASTTLDNAVKRSVAAGVTYAIAAGNGNIFGTPQNACNYSPARVPEAITVGATDSTDRRASWSNFGTCLDLFAPGVSITSGWYTSDTATNTISGTSMATPHTAGVAALYLQGNPSASPAQVSQAIVNGTTPNKVQDPRTGSPNRLLYSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NC07</accession>
    <name>A0A0F7NC07_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_31535</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019228.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_31535"/>
    <dbReference type="EnsemblBacteria" id="AKH86000">
        <property type="protein sequence ID" value="AKH86000"/>
        <property type="gene ID" value="AA958_31535"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_31535"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6661"/>
    <dbReference type="OrthoDB" id="680274at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH86000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="333" mass="37137" checksum="72B7782153D03D19" modified="2015-07-22" version="1">MARGSGRGGEFRPVYHLAGLDDDLRAVVDDLRVGRWMSMRALLGRTGADWAARTARSQVLGVVAAKSAVVQIWLDEEPESADARMMLARVAVGRAVQAHRQRHPSAGQLEEDARQACREAALLHPGDPVPWVCLLALAAVDVRQQRPEHRVAPPENLLPYGPWGLLDEVVKRDRYNREAYHRVLQLCSAAGGSQAYAMDFARWVGSWAPLASPLLVLPLFAHAEHYHFERRRGRGDALVHRQWSREDILRDTRRALDGWFDVTNADVRSVLDLNHLAHALTAAREFTEAARVFTALGPYATLLPWAYVTEDPERQDLAEAEFLRARSTALGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NC28</accession>
    <name>A0A0F7NC28_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl hydrolase family 15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_29940</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018974.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_29940"/>
    <dbReference type="EnsemblBacteria" id="AKH85746">
        <property type="protein sequence ID" value="AKH85746"/>
        <property type="gene ID" value="AA958_29940"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_29940"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6322"/>
    <dbReference type="OrthoDB" id="318658at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011613">
        <property type="entry name" value="GH15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045582">
        <property type="entry name" value="Trehalase-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19291">
        <property type="entry name" value="DUF5911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00723">
        <property type="entry name" value="Glyco_hydro_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5911" evidence="2">
        <location>
            <begin position="21"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_15" evidence="1">
        <location>
            <begin position="240"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH85746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="614" mass="68865" checksum="38A0516F7D08A4CA" modified="2015-07-22" version="1">MTREAEAPGGQSDVHAPRYLPVAEHGLIGDLRSAALVGTNGTIDWYCCPRFDAPSVFASLLDAERGGSFELAADVPTRTKQFYFPDTNVLITRFSADDGVGEIQDFMPITDDSREADRHRLIRRVVCVRGSLPFRARVAPRFAYGTEPHTVRVQDRQVVFASPSLTLALTSSVPVEVSGQDAWSLFKLREGQSAVFALDRVGGDVRPRHCPEAEAEEQFNATVGYWRRWLSQSRYRGRWREVVHRSALTLKLLTYAPTGAIIAAPTTSLPEHIGGQRNWDYRYVWIRDAAFCVYALLRLGFTDEAQAFMGFLSEHVRLEAAGAAGPLQIMYGIDGRHDLPERELPHLEGYRGSAPVRVGNGAVSQLQLDIYGALVDSLYLYDKWGQPVSSAYWDGISALVDWVCAHWDQPDRGIWETRGGSRNFLYSRLMCWVAIERAMRMARHRGLPADLVRWGRSRDDIYRRIMRHGWSTERSAFVQFEDSHLLDASLLMMPLAKFVSPTDPKWLATLDALGEDLVSDSLVYRYDPQSSADGLPGEEGTFSICSFWYVEALTRAGRVDEGRLAFEKMLTYANHLGLYAEEIGHTGEQLGNFPQAFTHLALISAAFNLDRTLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NC99</accession>
    <name>A0A0F7NC99_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 9">D-3-phosphoglycerate dehydrogenase</fullName>
            <ecNumber evidence="9">1.1.1.95</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AA958_25570</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 9">
            <text>(2R)-3-phosphoglycerate + NAD(+) = 3-phosphooxypyruvate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:12641"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18110"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="EC" id="1.1.1.95"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(R)-2-hydroxyglutarate + NAD(+) = 2-oxoglutarate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:49612"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.399"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 9">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 9">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.95" evidence="9"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018278.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_25570"/>
    <dbReference type="EnsemblBacteria" id="AKH85028">
        <property type="protein sequence ID" value="AKH85028"/>
        <property type="gene ID" value="AA958_25570"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_25570"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5391"/>
    <dbReference type="OrthoDB" id="1638924at2"/>
    <dbReference type="UniPathway" id="UPA00135">
        <property type="reaction ID" value="UER00196"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004617">
        <property type="term" value="F:phosphoglycerate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029009">
        <property type="entry name" value="ASB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006236">
        <property type="entry name" value="PGDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045626">
        <property type="entry name" value="PGDH_ASB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19304">
        <property type="entry name" value="PGDH_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143548">
        <property type="entry name" value="SSF143548"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01327">
        <property type="entry name" value="PGDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00670">
        <property type="entry name" value="D_2_HYDROXYACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0718">Serine biosynthesis</keyword>
    <feature type="domain" description="ACT" evidence="10">
        <location>
            <begin position="465"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AKH85028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="539" mass="55512" checksum="838B2AC48233EC0F" modified="2015-07-22" version="1">MSTAPATGATPGKPAVLIAEELSPATVDALGPDFDIRHCNGADRAELLAAIADVDAILIRSATKVDAEAVAAARRLKVVARAGVGLDNVDVPAATKAGVMVVNAPTSNIVTAAELACGLIIASARNIPQANAALKAGEWKRSKYTGVELNEKVLGVVGLGRIGVLVAQRMAAFGMSVVAYDPYVQAARAAQMGVKLVSLDELLETSDFITVHLPKTPETLGLIGDEALQKVKPSVRIVNAARGGIVDEEALTAALKEGRVAGAGLDVYATEPCTDSPLFQFDSVVATPHLGASTGEAQEKAGISVARSVRLALAGELVPDAVNVQGGVIAEDVRPGLPLAEKLGRIFTALAGEVAVRLDVEVCGEITQHDVKVLELSALKGVFEDIVAETVSYVNAPLFAQERGVEVRLTTSSESNAHRNVVTVRGTLASGEEVSVSGTLSGPKHQQKIVAVGEHDVDLTLADHMAFFSYGDRPGVVGTMGRILGEAGINIAGMQVSRAKAGGEALVALTVDDTIPPAVVQEIAGEIGAASARAVNLTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCB3</accession>
    <name>A0A0F7NCB3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dynein regulation protein LC7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_25675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018298.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_25675"/>
    <dbReference type="EnsemblBacteria" id="AKH85048">
        <property type="protein sequence ID" value="AKH85048"/>
        <property type="gene ID" value="AA958_25675"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_25675"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5412"/>
    <dbReference type="OrthoDB" id="1635683at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004942">
        <property type="entry name" value="Roadblock/LAMTOR2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03259">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00960">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Robl_LC7" evidence="1">
        <location>
            <begin position="12"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="140" mass="14619" checksum="14574F4ED7E36867" modified="2015-07-22" version="1">MSPLSQAAQNLNWLITNFVDNTPGVSHTVVVSADGLLLAMSDGFPRDRADQLAAVASGLTSLTAGASRIFEGGSVNQTVVEMERGFLFIMSISDGSSLAVLAHPECDIGLVGYEMALLVDRAGAVLTPDLRAELQGSLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCD7</accession>
    <name>A0A0F7NCD7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Siderophore-interacting protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AA958_26205</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Interacts transiently with the RNA polymerase catalytic core formed by RpoA, RpoB, RpoC and RpoZ (2 alpha, 1 beta, 1 beta' and 1 omega subunit) to form the RNA polymerase holoenzyme that can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH85139">
        <property type="protein sequence ID" value="AKH85139"/>
        <property type="gene ID" value="AA958_26205"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_26205"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5516"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="13"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="7">
        <location>
            <begin position="116"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="SnoaL-like" evidence="8">
        <location>
            <begin position="186"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH85139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="301" mass="32516" checksum="8E5127CCBFAE345A" modified="2015-07-22" version="1">MSVPHDDDLARAFEHERPRLLRVAYSTTGSLAEAEDCVQESWLRLRRVPDPGAIRDLRGWLTTVVGRLALDALGSARARRERYVGTWLPEPLVEPAGTVRPADPAEQVTLDESVSMALLVVLDELSPAQRTAFLLHDVFGLPFTQVAEVVGRTPAAVRQLASRARRHVERSRPHEPAPRAEQWRLVRAFAAACQEGDLEGLVRLLDPEVAWRGDGGGLVSSLPGVVRGAEQVARGLVAFGGGRLPPGTMRVVTVNGAAGLVLYGPEGDVSVAAFTVDGGRITAIDVQRNPEKLTSVRFPEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCD8</accession>
    <name>A0A0F7NCD8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_30645</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019079.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_30645"/>
    <dbReference type="EnsemblBacteria" id="AKH85851">
        <property type="protein sequence ID" value="AKH85851"/>
        <property type="gene ID" value="AA958_30645"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_30645"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6477"/>
    <dbReference type="OrthoDB" id="1356861at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH85851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="262" mass="26863" checksum="86A9CDD6804D613F" modified="2015-07-22" version="1">MERFEGYGVLVTGAGQGIGEAVARRFAAEGAGVLVTDRDGERAERAAAAIGAAGGTAAALACDVTDGAAVRAAVAYAAESFGGLHVLVNNAYAVHRDPPRFEDWREPDWYEDFEVTLHGAARCARAALPLLAAAPGRSAIVNIGSVNAERHYGEHAYSAAKAALVSLTRTLAVESAARGVRVNLVEPGTVRTAVWAGRPGVLARVEEHYPLGRVGEPDDIAAAVAFLASGDAAWITGVSLPVDGGLLASHLAMSRSIAGDGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCS4</accession>
    <name>A0A0F7NCS4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Toxin-antitoxin system, toxin component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_22555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH84517">
        <property type="protein sequence ID" value="AKH84517"/>
        <property type="gene ID" value="AA958_22555"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_22555"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4746"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="2"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="47" mass="5035" checksum="2C5458D28E83F080" modified="2015-07-22" version="1">MEVAAGAGVVHVRDSKTPDGPVLTFTPEAWAAFTVYATRTPGTVRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCW5</accession>
    <name>A0A0F7NCW5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_22815</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017819.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_22815"/>
    <dbReference type="EnsemblBacteria" id="AKH84562">
        <property type="protein sequence ID" value="AKH84562"/>
        <property type="gene ID" value="AA958_22815"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_22815"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4803"/>
    <dbReference type="OrthoDB" id="1197197at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013494">
        <property type="entry name" value="CHP02678"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09661">
        <property type="entry name" value="DUF2398"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02678">
        <property type="entry name" value="TIGR02678"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH84562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="415" mass="45535" checksum="8CEADA7D0B1A5A96" modified="2015-07-22" version="1">MSSPLGEFLDAHRSAELQRAARALLKEPLLLARGPQADSFRLVRRHAAELREWFDRNTGWPLRVDAESARLLRTPGTLADPTHPAREVSRSRAPFTRRRYVLLCLALAALERSEAQIALGRLAEQVVLDAADEQLAAAGLEFTLERRDERLDLAAVVRLLLHLGVLRRVAGDEDAYVSGSGDVLYDVERRVLAGLLAARRGPSLVTAAGFAERLAELTAETALDSDELRFRAIRYRLTRRLLDDPVLYYDELTDEELAYLTRQRAFLTSRITELTGLVAEVRAEGIAMVDPPGDLRPGGATYDLTDVRMPEQGTYGHVTLLLAEHLAAADGPVTEAALGAKVRELARQHAGFWAKSARQPGAEAELTGQALNRLTALGLVVRTAEGVVPRPALARYAVGEPVVRPVPDPRKAPEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCW8</accession>
    <name>A0A0F7NCW8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Protease HtpX homolog</fullName>
            <ecNumber evidence="12">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">htpX</name>
        <name evidence="14" type="ORF">AA958_22845</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CNQ-509</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cell membrane</location>
            <topology evidence="12">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the peptidase M48B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="12"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017824.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_22845"/>
    <dbReference type="EnsemblBacteria" id="AKH84567">
        <property type="protein sequence ID" value="AKH84567"/>
        <property type="gene ID" value="AA958_22845"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_22845"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4811"/>
    <dbReference type="OrthoDB" id="1918093at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00188">
        <property type="entry name" value="Pept_M48_protease_HtpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022919">
        <property type="entry name" value="Pept_M48_protease_HtpX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 12" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4 12" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0346">Stress response</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8 12" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="40"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M48" evidence="13">
        <location>
            <begin position="73"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AKH84567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="309" mass="33250" checksum="C373B21571F95AEF" modified="2015-07-22" version="1">MRSRFEPDRRLTTRMVVTMFLLGLVYVAFVAALIALLKSVVLVVVIAVGVLALQYWFSDRIALYAMHGRFVTPEEEPQLHGIIDRLCATADMPKPRVAVSGMDLPNAFATGRNADHAVVCVTKGLQRRLTTEELEGVLAHELSHIAHRDVAVITIASFLGVIAGLVVRFAFYSQIFGGRSRDQNTIVILAAVMAVSAVVYAVSFVLIRALSRYRELAADRAGAMLTAKPSALASALTKISGDIARIPTQDLRTSQAFNAFFFTPAIRPGTAMANLFSTHPTLERRLEALAGISAELGEPGGGGDAAGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCX7</accession>
    <name>A0A0F7NCX7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Amino acid adenylation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AA958_31920</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Antibiotic biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019289.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_31920"/>
    <dbReference type="EnsemblBacteria" id="AKH86061">
        <property type="protein sequence ID" value="AKH86061"/>
        <property type="gene ID" value="AA958_31920"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_31920"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6741"/>
    <dbReference type="OrthoDB" id="572620at2"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00044"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901362">
        <property type="term" value="P:organic cyclic compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010060">
        <property type="entry name" value="NRPS_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01720">
        <property type="entry name" value="NRPS-para261"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="3 6" id="KW-0596">Phosphopantetheine</keyword>
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        <location>
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        </location>
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            <position position="996"/>
        </location>
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            <position position="2531"/>
        </location>
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            <position position="4062"/>
        </location>
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        <source>
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        </source>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
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    </evidence>
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            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AKH86061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="4611" mass="484219" checksum="0E6E4C996E1D9CE9" modified="2015-07-22" version="1">[encoded data, 4611 characters]</sequence>
</entry>
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        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
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                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <end position="34"/>
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            <end position="58"/>
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            <end position="98"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="155" mass="16103" checksum="0FF310F2D0AF713C" modified="2015-07-22" version="1">MIQLPSRPAVAAFTRFVACGGGVGLASSGALVLLDGAMPMMVANALITVVSTLLATELHGRVSFRSERGGWRVHLQSALTVAVCYAFTTAALLALHAAQANPSVVTEQAVYLAASALAGIGRFAVLRAVVFADDRRTRRGHRTPALARTSVTMAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDK3</accession>
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        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="PATRIC" id="fig|444103.5.peg.7064"/>
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        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="AKH86321.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="209" mass="22340" checksum="9D73123387A96E39" modified="2015-07-22" version="1">MSDRIPQPYEDPAGSDDRGAGPGGPGRRGGPGDGHGRPPRRRRSLARTLAPLGVAAWALLELWLLIMLGSRIGVLGVFAVLVGGLILGSVVIKRAGRRAWRSLAEQLQRQQRGEAPEPDRARGSGNGLTMLAGLLLMVPGLVTDAAGLLLLLPPVRALVRRSLTRAIERSASGSDLGQAYTQARIHRPDGKVVQGEVIRDEDEDRPPER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDN7</accession>
    <name>A0A0F7NDN7_9ACTN</name>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_33545</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
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        </lineage>
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    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AKH86336">
        <property type="protein sequence ID" value="AKH86336"/>
        <property type="gene ID" value="AA958_33545"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_33545"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.7084"/>
    <dbReference type="OrthoDB" id="370329at2"/>
    <dbReference type="Proteomes" id="UP000034283">
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    </dbReference>
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        <property type="term" value="F:DNA binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
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        <location>
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        </location>
    </feature>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH86336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="281" mass="30053" checksum="DFA65A423CDFDC79" modified="2015-07-22" version="1">MTNRTDADQPKYWVRSLGRAAEILEALASPPPGDGLSVTEVAQRCGVSKSTAFGTLQTLRAFGLVSDDGEGMSRRYRLGMGLARLGDRARSQVSLRRVAHPVLRDLSARTGMASRVAVPEGGLAVVVDQVEVDHRVRLDLRMGERELPHCTGLGKALLSAMPEAEAAAVIERHGLPRRTGRTITDPDTFLAHLRDIARVGYALDDEEDAEGIICIGAPVRDDRGACAGAVSITGLKLGLPAWRYQELGGEVRDAAHRISRELGWPGEDGDAPGAAPRAGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDP8</accession>
    <name>A0A0F7NDP8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Lysine N-acyltransferase MbtK</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Mycobactin synthase protein K</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_33570</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Acyltransferase required for the direct transfer of medium- to long-chain fatty acyl moieties from a carrier protein (MbtL) on to the epsilon-amino group of lysine residue in the mycobactin core.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Siderophore biosynthesis; mycobactin biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019563.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_33570"/>
    <dbReference type="EnsemblBacteria" id="AKH86341">
        <property type="protein sequence ID" value="AKH86341"/>
        <property type="gene ID" value="AA958_33570"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_33570"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.7089"/>
    <dbReference type="OrthoDB" id="1538300at2"/>
    <dbReference type="UniPathway" id="UPA00011"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019290">
        <property type="term" value="P:siderophore biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019432">
        <property type="entry name" value="Acyltransferase_MbtK/IucB-like"/>
    </dbReference>
    <dbReference type="SMART" id="SM01006">
        <property type="entry name" value="AlcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AlcB" evidence="6">
        <location>
            <begin position="28"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH86341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="200" mass="21368" checksum="2E5B6544834031C6" modified="2015-07-22" version="1">MATADPAPRDRTPRHEQRADGFGTVRVVPVVPDADAALLHGWVTAERARFWGMAGLSRTQVRDVYAHMDTLPTHHAHLLLRDGAPVALVQTYEPAADRVSECYPAEPGDLGIHLLISPAAGAAERGFTAALMRVITGWAAAAGARRLVAEPDAGNGPAIDRLRREGFALGPEVTLPEVDLPEVYLPPKRARLAFLPLAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-08-12" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDV3</accession>
    <name>A0A0F7NDV3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DGPF domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_10380</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the YciI family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019933.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86665">
        <property type="protein sequence ID" value="AKH86665"/>
        <property type="gene ID" value="AA958_10380"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_10380"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2187"/>
    <dbReference type="OrthoDB" id="2051456at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005545">
        <property type="entry name" value="YCII"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03795">
        <property type="entry name" value="YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YCII" evidence="2">
        <location>
            <begin position="17"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH86665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="135" mass="14771" checksum="6C6C4B6D12E87920" modified="2015-07-22" version="1">MAKYLLLKHYRGAPAAVNDVPMDQWEPEEVTAHIQYMRDFAARLEATGEFVGEQALAPEGTFVRYDGEGRPPVTDGPFAETKDLIAGWMVIDVETYDRALELAAELSAAPGAGGKPIHEWLEIRPAYGVQAPAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDV4</accession>
    <name>A0A0F7NDV4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ROK family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_28840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ROK (NagC/XylR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018821.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_28840"/>
    <dbReference type="EnsemblBacteria" id="AKH85588">
        <property type="protein sequence ID" value="AKH85588"/>
        <property type="gene ID" value="AA958_28840"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_28840"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6077"/>
    <dbReference type="OrthoDB" id="1130699at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01125">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="393" mass="40487" checksum="A2A6B3DFD124F6D2" modified="2015-07-22" version="1">MTARPANAHQARLLRLLRDGGPNSRAQLGDQVELSRSKLAVEIDRLLQTGLVVADGLAASRGGRRSHNIRLAPSLRFLGVDIGATSIDVAVTNAELEVLGHLTQPMDVREGPVAVFEQALAMAAKLRASGVAEGFDGAGIGVPGPVRFPEGVPVAPPIMPGWDGFPVREALSQELGCPVMVDNDVNIMAQGEQHAGVARAVRDFLYVKIGTGIGCGILVGGEVYRGTNGSAGDIGHIQVEVDGRPCACGNRGCLEAYFGGYALARDAENAAREGRSAQLAARLEETGELEAKDVAAAATAGDAVALDLIREGGTRTGQVIAGLVSFFNPGLVVIGGGVTGLGHTLLAAIRTQVYRQSLPLATGNLPIVLGELGPTAGVIGAARLTSDHLFSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NE13</accession>
    <name>A0A0F7NE13_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Laminin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_12600</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_12600"/>
    <dbReference type="EnsemblBacteria" id="AKH86720">
        <property type="protein sequence ID" value="AKH86720"/>
        <property type="gene ID" value="AA958_12600"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_12600"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2647"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006558">
        <property type="entry name" value="LamG-like"/>
    </dbReference>
    <dbReference type="SMART" id="SM00560">
        <property type="entry name" value="LamGL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="LamGL" evidence="3">
        <location>
            <begin position="709"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="domain" description="LamGL" evidence="3">
        <location>
            <begin position="935"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="domain" description="LamGL" evidence="3">
        <location>
            <begin position="1153"/>
            <end position="1321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="167"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="471"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH86720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="1341" mass="142470" checksum="CC30FBF71ECFC51A" modified="2015-07-22" version="1">MFATPDGNLEAREYLRPVRTRVGGEWKAIDTHLAPADGGMVAPGVTTVGMEFSGGGTAPLVRMTKAGRELSLSWPGELPQPRLEGDAVVYPEVLPGVDLRMGVQADGFTQLLVVKSAEAAQNPELAELRLHLGATGMSVRETAAGGLEAVDAGAGGAVFEAPQPVMWDSSGGTTPGARGAAGGEPADEPAAGESGKLAPVDVQVAQAPDQLVLTPDPQVLKGADTVYPVFIDPQWYSPRASAWTFASKYWASSPQWKFNGENNAGMGYCGWDYCAPHDTKRVFYRIPTSRFAGKSILSAEFVVRNNWSASCSERSVELWRTKDISSSTTWNSQDAGSGFWLDKLDTRSFAYGYDGCAAKDAEFGIKSAVQQAANNKWSTMTFGLRAASEDDKYAWKRFSDKAFLRVKYNRPPPQIKMAQLTMEYGGVCKRPGEKARIRSLGKISANEIRDPDGDHVAVQFQAKWTDASGVTHRWSPSRTPFEPSGSSFTVSLPNSGSNPIPKNENVNWYARAYDGAQWSPWSYAGDTKTACYFVWDTNEPAAPTVVSGEYPESDPADPNDPWLDGVGQYGTFTLDSPSSDANRYWYGINGDPVPGNQISTSGGAARDVKILPTRSGLNFITVQSFDTAGNNSTIRTYQFRVKAGQPDRATWQLDESAGATQAEGSTPARTLALKGGATTGAAGTDGTALGLNGTDAYAATDLSAVNNTGGFTVSAWVKLDAKPTAGAAVVASQPGNERMGFALHYAAAHDRWIFNGFSADTPDATVSRAMAPNPGGVQTGSWTHLVGSYDSVEDKLRLFVNGTLVGETAFVSTWNARRGLQLGAGSAAGVAKDFFPGTLDKVQIFDKRIAQDEVDKLYAKQPVGDPGRPAIAVFELDEPAGATEVSGRGGVLPARYHGGVTTGVPGVAGKASKFNGTDGYARIGQTSGPHINSERSFAVSAWAKLDAKPDRQATVVAQAGEFALGFELYYSAAYDRWVFNQYASDTPGAPIIRAMADQPGDAHAGTWAHLVGVHDTTANTLTLYINGKKAGSTTLVDAFYAAGSMYVGAVSVNNVLKSHFPGTIDDVRLFDRPISPAEVQQLYKQRAFVKGRWLFEEVSDSVPATSPDASGEGRPMTVEGGAKLGAGWIDFSGLQLDGVDDHAAASMPVDTSGSFTVTGWAQAAAMPGGAVTVASAEGGATSAFSVRYLPDAADPNAPGRWQVVLPSSDAADAPVVRADNGNFYDVREWNHLALVYDGFARELKLYVNGVLEETACSDSDGDGEPDQAGCKDLVPWAEHAQSFKATGELQIGRAKTAGGFDEYFPGTIDDVWAFQGPLSEDQVAWLASQWFDVPTQVPPGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NE29</accession>
    <name>A0A0F7NE29_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_25015</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018178.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_25015"/>
    <dbReference type="EnsemblBacteria" id="AKH84927">
        <property type="protein sequence ID" value="AKH84927"/>
        <property type="gene ID" value="AA958_25015"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_25015"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5272"/>
    <dbReference type="OrthoDB" id="1063432at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002838">
        <property type="entry name" value="AIM24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036983">
        <property type="entry name" value="AIM24_sf"/>
    </dbReference>
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        <property type="entry name" value="Trp_RNA-bd_attenuator-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01987">
        <property type="entry name" value="AIM24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51219">
        <property type="entry name" value="SSF51219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH84927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="216" mass="22806" checksum="68E091F8C117DC7F" modified="2015-07-22" version="1">MPFRMLNSKIAEAQVLPGQTMFSQRGAMLAYTGQVSFTPNIQGGQGGLTSMIGRRVANEATPLMTVEGSGTVMFGHGGHEVHVIEMAGDTLYVEADRLLAFDGSLQQGTMFMGSQGGVMGMVRGQVTGQGLFTTTLAGHGAVAVMAHGGVLELPITPQRPVHVDPQAYVAHRGQVRNKLSTALGWRDMVGRGSGEAFQLELSGNGTVYVQASEEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NEX5</accession>
    <name>A0A0F7NEX5_9ACTN</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_26970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_26970"/>
    <dbReference type="EnsemblBacteria" id="AKH85277">
        <property type="protein sequence ID" value="AKH85277"/>
        <property type="gene ID" value="AA958_26970"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_26970"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5675"/>
    <dbReference type="OrthoDB" id="1206711at2"/>
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    </dbReference>
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        <property type="entry name" value="DUF3710"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12502">
        <property type="entry name" value="DUF3710"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="256" mass="27495" checksum="60353DAF059C9541" modified="2015-07-22" version="1">MFGRRRKGQEEPADKLADGVAAEDAESADEPEDGEERRYALPPEERPDGPWDISEVEDASRGRVDLGGLLVPGVEGMELRVEVAGDSIVAATVVLRDSAIQLQGFAAPKNEGIWGEVRTEIANGITKQGGIIDERKDTLGWELRAQVPVKLPDGKSGMQVVRFVGCDGPRWFLRGVISGHAAVQPQAAGVLEKIFRETVVVRGDGPMAPRDPIVLQLPTDAQMVPDGVQQDEASEGSRFAGGIDSLARGPEITEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NEY1</accession>
    <name>A0A0F7NEY1_9ACTN</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_24245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020372.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_24245"/>
    <dbReference type="EnsemblBacteria" id="AKH87005">
        <property type="protein sequence ID" value="AKH87005"/>
        <property type="gene ID" value="AA958_24245"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_24245"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5109"/>
    <dbReference type="OrthoDB" id="1930882at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016119">
        <property type="entry name" value="Br/Cl_peroxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxi_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="SSF48317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002520024" evidence="1">
        <location>
            <begin position="22"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH87005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="501" mass="54990" checksum="62BB0C9FBF72AB33" modified="2015-07-22" version="1">MLLGGASTAALATLGTGTAAAAGQGTGPAAKPAAAAEFDFDTGNFHRDLLSTAANPSEEPLGPMDATVLVYLTHLTMTAWFDALAPYHPTAVGRHSRIPRRPASESNTNRNKNVAAFHAANVVFQSVFKERVAAFRQLMTTLGLDPDDQSTDPTSPVGIGNLAARGVLKAKARDGMNLFGDEGRKYHGQPYEDYTGFEPVNTAYKLVNPSKWQPARHPHRRRVGGGPGDKGIFVVQHMVTPQMALVKPDTYRHPSQFPLAPPDHLDHTDPRRYKRSVDEILEASATLDDEQKVKAEFFDNKFLGIGQSTKAAGIAHDLELDDWVHLIYTSSLAQVEDLIAAWHYKVKYQAPRPFSAIRHVYGKKKVSAWGGPGIGTVHDMPADEWASFLPVGDHPDYPSGSTTLCAAEAQAARRFLGDDRLDWTWPIPAGWTLTEPGITPARDMELHYGTWTEFVKDCGYSRLWAGVHFTTTVERSMEFGTQFGDLAYEFAQKYIKGDVED</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NEY4</accession>
    <name>A0A0F7NEY4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_00065</name>
        <name evidence="3" type="ORF">AA958_00250</name>
        <name evidence="4" type="ORF">AA958_27025</name>
        <name evidence="5" type="ORF">AA958_34195</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH80832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH80857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014199.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH80832">
        <property type="protein sequence ID" value="AKH80832"/>
        <property type="gene ID" value="AA958_00065"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH80857">
        <property type="protein sequence ID" value="AKH80857"/>
        <property type="gene ID" value="AA958_00250"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH85287">
        <property type="protein sequence ID" value="AKH85287"/>
        <property type="gene ID" value="AA958_27025"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86439">
        <property type="protein sequence ID" value="AKH86439"/>
        <property type="gene ID" value="AA958_34195"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_00065"/>
    <dbReference type="KEGG" id="strc:AA958_00250"/>
    <dbReference type="KEGG" id="strc:AA958_27025"/>
    <dbReference type="KEGG" id="strc:AA958_34195"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.14"/>
    <dbReference type="OrthoDB" id="2020052at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025161">
        <property type="entry name" value="Put_IS4/IS5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_Tnp_1" evidence="1">
        <location>
            <begin position="96"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH80832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH80857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH85287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH86439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="260" mass="30152" checksum="B5212EB1797EF4A2" modified="2015-07-22" version="1">MTDAEWAVVRSLLPVPGWMNGKGGRPEGYCHRQMIDAIRYLVDNGIKWRAMPADFPAWDRVYAFFRRWRDHRLITEFHDRLRARVRESEGREREPTAAIVDSQSVKAAASVPARSRGFDGGKKINGRKRHLIVDCLGLLLMVLVTPADVTDRDAACGMLPRLLARHRKIRLVWADGGYAGRLVDWARNRLRLTLEIVKRSDDTRGFVVLPRRWCVERTLGWLMRSRRLTRDYETRPATSEAVVHWSMAMLMGRRIARHRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NF77</accession>
    <name>A0A0F7NF77_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_27405</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018576.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_27405"/>
    <dbReference type="EnsemblBacteria" id="AKH85342">
        <property type="protein sequence ID" value="AKH85342"/>
        <property type="gene ID" value="AA958_27405"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_27405"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5775"/>
    <dbReference type="OrthoDB" id="567019at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012938">
        <property type="entry name" value="Glc/Sorbosone_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011041">
        <property type="entry name" value="Quinoprot_gluc/sorb_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07995">
        <property type="entry name" value="GSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50952">
        <property type="entry name" value="SSF50952"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519401" evidence="1">
        <location>
            <begin position="34"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="GSDH" evidence="2">
        <location>
            <begin position="62"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH85342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="377" mass="39043" checksum="C524069D44B2B7D2" modified="2015-07-22" version="1">MNESIPKRRSGIAAVIALTVALGGCTAPDDRPAASAPPAGAGTGGADAAVVPGEVSEIATRLDMPWGLTFLPDGTALVSSRLSGEIRRVPAAGGRTSLVGTVPGVRKSSEGGLLGLAASPDFASDRTVYAYVSAAPTNRVVALRIGDDFRSVTRERVVLSGIETADRHHGGRLRIGPDGNLWIGTGDAFRPGNAADDSSLSGKVLRVRPDGSVPDDNPFGTAVYSTGHRNVQGLTFGPDGTMYASELGHRTWDEVNVLRSGADYGWPETEGTAGETGEPPLFTVHPDDASPSGIAYAGGSLWMGALGGQRLWQLPVDGPRAAGDPIAHYVGEYGRIRTVETAPDGSLWITTSNTDGATWGGTEPRPGDDRILRIGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NF95</accession>
    <name>A0A0F7NF95_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carbon monoxide dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_31620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019241.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_31620"/>
    <dbReference type="EnsemblBacteria" id="AKH86013">
        <property type="protein sequence ID" value="AKH86013"/>
        <property type="gene ID" value="AA958_31620"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_31620"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6678"/>
    <dbReference type="OrthoDB" id="1017413at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005107">
        <property type="entry name" value="CO_DH_flav_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036683">
        <property type="entry name" value="CO_DH_flav_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002346">
        <property type="entry name" value="Mopterin_DH_FAD-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03450">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00941">
        <property type="entry name" value="FAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01092">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55447">
        <property type="entry name" value="SSF55447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="288" mass="29338" checksum="451D71170CB3DFE0" modified="2015-07-22" version="1">MIPAAFDYVRPESVGAAVSALADAGAAGREAKVLAGGQSLLPLLRMRLAFPDLVVDAGRIPELRGVRDDGDALVIGALTTHHEVLADPLVRRHAGLLAAATATVADPAVRHRGTLGGSLAHADPAADLPAVVLALDAELTAVGPGGSRTVPAREFFTDYLTTALAPDELLAAIRVPKYDGWGFRYEKFSRAAQAWALVGVAAAVRHEGGRIAEARIGLTSMGPTPVRAAAAEAALAGAQATEEPVAEAAAAAAEGTRPAADLSGSAEYRAHLARVLTRRAVLAAAGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFD4</accession>
    <name>A0A0F7NFD4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Enoyl-CoA hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_31875</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019281.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_31875"/>
    <dbReference type="EnsemblBacteria" id="AKH86053">
        <property type="protein sequence ID" value="AKH86053"/>
        <property type="gene ID" value="AA958_31875"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_31875"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6731"/>
    <dbReference type="OrthoDB" id="886786at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH86053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="434" mass="46622" checksum="F680859B15AC3DDD" modified="2015-07-22" version="1">MIGDVRAVTARDGWAGVGAALARAEESIAALPPPDARTAAQRTRAAGVQDEARALRTAFLDTHVDAVYDRLTEGRTTPLRLADLVSAAAVAYPGLVPTAGQLAAERKRLQAGKEGHEIDQGIFLRAVLASPVAGAHLLDAMLRPTPRALELLPRFTETGLVDTRSVRLERRDGAAHLTMHRDDCLNAEDEQQVDDMETAVDLALLDPGVRVAVLRGGEMTHPRYRGKRVFSSGINLKSLHAGDISLVGFLLRRELGYIHKIVRGVRGVGGASWHSRTVEKPWIAAVDTFAIGGGMQLLLVCDHVLAASDAYVSLPAAREGIVPGAGNLRLGRHTGPRISRQVILQDRRLPATDPDARLVLDEVVEPAAMDDAIAAAVDRLGGPAVVPNRHMLNVAEEPAAEFRRYMAEFALQQALRIHGADVVGKVGRFTQRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFM7</accession>
    <name>A0A0F7NFM7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SIS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_28435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH85517">
        <property type="protein sequence ID" value="AKH85517"/>
        <property type="gene ID" value="AA958_28435"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_28435"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5992"/>
    <dbReference type="OrthoDB" id="1605411at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05013">
        <property type="entry name" value="SIS_RpiR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035472">
        <property type="entry name" value="RpiR-like_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13580">
        <property type="entry name" value="SIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SIS" evidence="1">
        <location>
            <begin position="49"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="257" mass="26640" checksum="DAE9F0338D773C0C" modified="2015-07-22" version="1">MTDDTHDSRDPGGASGAAARAAVAGRFRGLLDDLDRTAGTAVADAATLILDAVAAGGLVYAAGAGHSLAMVCETFYRAGGLACVRPVWDPEILPLNGATASTAAERRPGSGRATVERVKPGPQDVVVVFSTSGRNPYPVEIAQECMARGVPVVAVTSMQASASATARSSTRLADHATVVLDTRVPPGDVVHPQESPRTAAVSTVLGAYTWALLLAELDERAAERGVELPRWVSANVPGGDEANRRNFTRYGGRVPEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NGH5</accession>
    <name>A0A0F7NGH5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_04255</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_04255"/>
    <dbReference type="EnsemblBacteria" id="AKH86539">
        <property type="protein sequence ID" value="AKH86539"/>
        <property type="gene ID" value="AA958_04255"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_04255"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.892"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="9"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="133"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="198"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="306"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="330"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="364"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="400"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="435"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="9"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH86539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="471" mass="49015" checksum="C681C60BB94EB47C" modified="2015-07-22" version="1">MPPAQVRAMILVAMAATFMAMMDSYIVNVAIPSIRSDLGASVSAAEMTVGGYILVYGLFLVTGGRLGDIVGYKRMFLAGLGLFTVASLCCGVAPSPETLIAFRCFQGFAAALFFPQILSIIQTSFEGARRDRALALFGATIGLAAITGQLIGGVLVHLDLFGWGWRPIFLVNLPLGLAAIAGAALTMPGVRSPQRPRLDLPGVGLLTLALLLLSFPLAEGRTAGWPLWSYAMLVASVPCFVAFGWWQRRLSDGGGQPLISPPLLRLRAYRSGNALFFAFFACNAGLFFVLAVQLQSGLGYSALESGLLFAPLGIAFTATSMALPRIMPRLGLHVLTAGYGLNALGYLLLLLTTLAVGDSLSGPILIPALVIIGVGQGLGVSPLLGAALTGVPPQEAGSAAGVLETVGQLGMSLGITLVGLVYFSTLGDGMSQHEYVHAFTVTLVLNLALSLLALAFVPPLRKTAAAAQAAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NGK3</accession>
    <name>A0A0F7NGK3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_34045</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019645.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_34045"/>
    <dbReference type="EnsemblBacteria" id="AKH86423">
        <property type="protein sequence ID" value="AKH86423"/>
        <property type="gene ID" value="AA958_34045"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_34045"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.7193"/>
    <dbReference type="OrthoDB" id="1204073at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019120">
        <property type="term" value="F:hydrolase activity, acting on acid halide bonds, in C-halide compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02588">
        <property type="entry name" value="HAD_L2-DEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006328">
        <property type="entry name" value="2-HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01493">
        <property type="entry name" value="HAD-SF-IA-v2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH86423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="225" mass="25788" checksum="DF0DDDB56E621D2F" modified="2015-07-22" version="1">MSEKRWVTFDCFGTLVDWRHGIATGIDMVAPGRGWELLDVYNRHEPAVQTEHPGMRYSEVLAEALQRTADEVGIELVEDDARVLTTGIPFWPVFPETRQALRELQEAGWNLALLTNCDRVIIGETQRRLQIQFDAIVTAEDSGAYKPTHNHFQHFEQSLGVTRDRWVHVAQSYFHDMVPASQLDISRVWINRLDEKNDPSIAHAVRRDLTDLTATVNEVHQYVNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NGN9</accession>
    <name>A0A0F7NGN9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_30910</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019120.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH85892">
        <property type="protein sequence ID" value="AKH85892"/>
        <property type="gene ID" value="AA958_30910"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_30910"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6532"/>
    <dbReference type="OrthoDB" id="1914729at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014325">
        <property type="entry name" value="RNA_pol_sigma-E_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02983">
        <property type="entry name" value="SigE-fam_strep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="5">
        <location>
            <begin position="19"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="6">
        <location>
            <begin position="113"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH85892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="181" mass="19546" checksum="BDA54C2276C8D601" modified="2015-07-22" version="1">MGIPSAGHDAAATAEFREFFEHHYAELTRLANSLSGEAEGADDVAADALAALWHRWDRVRAADHPAAYARGVVANLVRSRIRSAVRERRRLALYWTGGHEHAEGPDVPAVVDVRDALRGLTFRKRACVVLRHAFDLSERETAHTLGISVGTVKSQTAKGVAQLEAALAGGAQPPSGRVRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NGR0</accession>
    <name>A0A0F7NGR0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sugar ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_31030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019140.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_31030"/>
    <dbReference type="EnsemblBacteria" id="AKH85912">
        <property type="protein sequence ID" value="AKH85912"/>
        <property type="gene ID" value="AA958_31030"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_31030"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6558"/>
    <dbReference type="OrthoDB" id="447734at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002520081" evidence="1">
        <location>
            <begin position="26"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="431" mass="46234" checksum="AC2A93D03ACFE3CA" modified="2015-07-22" version="1">MSSSTRHRTRPGRGTLVRGRPVALAAAGLLALTACGGSDGGSGSDGGPVTLRMTIWTGNEEHLKLLNSIAADYRKKNPDVKEIKFDTLPVESYTTALTTQIAGGKAPDLAWIFENSAPDFVASGALAEIEDDEDVLPAAKKLWQHEGKLYAYPFSTSPFGVFVNTDMLKEAGQPAPAELIEQGKWTWEEVAKVGGAVRAETGEAGMVIRDFDYKMWDNLATVWDGWGAEPWSEDGRTCAFDEPEMTEAMTFLHDAIFADEAMPAPGTTADFFAGEAAMTVTQISRASLLDDSFGWDFVPLPEGPAGSYDVIGQAGLGVLGNGDNVEEAVDFLAFMTNEKNSAALGRYFPQARASQLDADTLATSNPQLKPAQLEEVVIGGIENGKVKPTHTNQAELFDAVRAALDPLWKPDADVAKTLQDVCSAIQPQLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NGT8</accession>
    <name>A0A0F7NGT8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family acetyltraansferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_31200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019170.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_31200"/>
    <dbReference type="EnsemblBacteria" id="AKH85942">
        <property type="protein sequence ID" value="AKH85942"/>
        <property type="gene ID" value="AA958_31200"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_31200"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6593"/>
    <dbReference type="OrthoDB" id="2055010at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="14"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="175" mass="19090" checksum="1D234255CF5F131B" modified="2015-07-22" version="1">MARYRTPACAPADVRIRHIAAHDWGAIAALEDRAYADRALAEGRAALEFRGRASPGTCFVLDADGAPGGYLLALPYPAFRCPELRGAEESRHATDNLHLHDIVVAEHLRGAGLAGRLLARLTATARARRFRRISLVAVAGTASFWTRRGYRPHYDVAPPAGYGPWAVYMSREAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NGW1</accession>
    <name>A0A0F7NGW1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chaperonin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_10645</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GroES chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019943.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_10645"/>
    <dbReference type="EnsemblBacteria" id="AKH86674">
        <property type="protein sequence ID" value="AKH86674"/>
        <property type="gene ID" value="AA958_10645"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_10645"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2239"/>
    <dbReference type="OrthoDB" id="1965002at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00320">
        <property type="entry name" value="cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.33.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020818">
        <property type="entry name" value="Chaperonin_GroES"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037124">
        <property type="entry name" value="Chaperonin_GroES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10772">
        <property type="entry name" value="PTHR10772"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00166">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00883">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH86674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="100" mass="10958" checksum="141875680BC1F185" modified="2015-07-22" version="1">MLHDRVLVRTDSAEGERRSSGGIVIPATAAVGRRLTWAEVVATGQNVRTVEPGDRVLFDPEDRGEVEVRGVGYVLLRERDLHAVASERLEGTEDSTGLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NHC1</accession>
    <name>A0A0F7NHC1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Allantoate amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_11545</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019964.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_11545"/>
    <dbReference type="EnsemblBacteria" id="AKH86693">
        <property type="protein sequence ID" value="AKH86693"/>
        <property type="gene ID" value="AA958_11545"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_11545"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2429"/>
    <dbReference type="OrthoDB" id="829830at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016813">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010158">
        <property type="entry name" value="Amidase_Cbmase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32494">
        <property type="entry name" value="PTHR32494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001235">
        <property type="entry name" value="Amidase_carbamoylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01879">
        <property type="entry name" value="hydantase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>allantoate</name>
            <dbReference type="ChEBI" id="CHEBI:17536"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>allantoate</name>
            <dbReference type="ChEBI" id="CHEBI:17536"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>allantoate</name>
            <dbReference type="ChEBI" id="CHEBI:17536"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="367"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001235-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001235-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH86693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="406" mass="42438" checksum="657438066C9805E9" modified="2015-07-22" version="1">MWRELRPLGRYAPSGGYRRFAWTAADADCRAWFRAQASARGLAYETDRNGNQWAWLGDPAAGGAVVTGSHLDSVPDGGAFDGPLGVVSAFAALDELRARGVRPDRPLGVVNFGDEEGARFGLACVGSRLAAGRLTAAAAHELTDADGVTLPRAMERAGHDPGGIGPDPERLARIGAFVELHVEQGVALAGTDHAVGVASAIWPHGRWRFDFRGEANHAGTTRMEDRHDPMLTYAHTVLSARKKAAQAGARATFGKVAVEPNGVNAIPSLVRGWLDSRAADEETLHTLVAAVEQAARERARRDGTAVEVTRESMTPVVDFDHALRDRLAARLGGAPLLPTGAGHDAGILSGAVPAAMLYVRNPTGVSHAPAESADEDDCAAGVRALADVLADLGGDGSSVPRSEGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NHG4</accession>
    <name>A0A0F7NHG4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_18445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020196.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_18445"/>
    <dbReference type="EnsemblBacteria" id="AKH86869">
        <property type="protein sequence ID" value="AKH86869"/>
        <property type="gene ID" value="AA958_18445"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_18445"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3872"/>
    <dbReference type="OrthoDB" id="1775418at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028978">
        <property type="entry name" value="Chorismate_lyase_/UTRA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011663">
        <property type="entry name" value="UTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07702">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00866">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64288">
        <property type="entry name" value="SSF64288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="237" mass="26190" checksum="160BADC2ACF6C440" modified="2015-07-22" version="1">MAGEYPPGSQLPTLPELASTNGVSETTIRQALAMLRSEGLIETRARAGTLVRARPPVHRLQADRYRNRGARRPATPYTRDQGIGWSEYRLDKRFEQVEADDDLAELFEGESGERLLARHFVFHDNDVPTQMSTSYVRWSDVADTPVADPVNEPWPGGTRAQLATLGIRVVRVTEALTGGMPTPDEAETLRLGAGVPVLRIVRRHIATGGRVVEVARPIVRRADTTVVEYVVDLDDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NHN9</accession>
    <name>A0A0F7NHN9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Plasmid partitioning protein ParB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_16170</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ParB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_16170"/>
    <dbReference type="EnsemblBacteria" id="AKH86818">
        <property type="protein sequence ID" value="AKH86818"/>
        <property type="gene ID" value="AA958_16170"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_16170"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3407"/>
    <dbReference type="OrthoDB" id="653368at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041468">
        <property type="entry name" value="HTH_ParB/Spo0J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004437">
        <property type="entry name" value="ParB/RepB/Spo0J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003115">
        <property type="entry name" value="ParB/Sulfiredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036086">
        <property type="entry name" value="ParB/Sulfiredoxin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17762">
        <property type="entry name" value="HTH_ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02195">
        <property type="entry name" value="ParBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00470">
        <property type="entry name" value="ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110849">
        <property type="entry name" value="SSF110849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00180">
        <property type="entry name" value="parB_part"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ParB" evidence="4">
        <location>
            <begin position="76"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH86818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="355" mass="38569" checksum="BC8F6188427A6A15" modified="2015-07-22" version="1">MGALIPAAPTPADDSGPLVGGATMSPGAVPVIVSERAPQPEPQGYEEQVPPEHAYEAPPAVEGAADSGEVAGAHFAEVPLDAITPNPRQPREVFDEDSLAELVTSIQEVGLLQPVVVRRLGSDRYELVMGERRWRACREAGMERIPAIVRATDDEKLLLDALLENLHRAQLNPLEEAAAYDQLLRDFECTHDQLADRIGRSRPQVSNTLRLLRLSPPVQRRVAAGVISAGHARALLSVEDASEQDRLAHRIVAEGLSVRAVEEIVTLMASEPKTGRRPKAPRAGNRMSPALTDLASRLSDRFETRVKVDLGQKKGKIVVEFASIEDLERILGSMAPGEGRVLEKKLSDEDADEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NHY8</accession>
    <name>A0A0F7NHY8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_19105</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86893">
        <property type="protein sequence ID" value="AKH86893"/>
        <property type="gene ID" value="AA958_19105"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_19105"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4015"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH86893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="173" mass="19721" checksum="4C93575CBB8D6C01" modified="2015-07-22" version="1">MPPSVPSDRLAGLLDRARSAFDHVVIVLVCVHALNGTDIRRLFLSDLDLPRERLLVRRPGRRHVIYLDETTYRSVAEWTRERHRRWPASANPHLLINRWTAVDPNAAITTAALHGTFQHAGVSMQTARQDRILHEAYETEDPLHLIRLFGISATTAMRYITAAHPERTAKLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NI46</accession>
    <name>A0A0F7NI46_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_29700</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020529.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_29700"/>
    <dbReference type="EnsemblBacteria" id="AKH87124">
        <property type="protein sequence ID" value="AKH87124"/>
        <property type="gene ID" value="AA958_29700"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_29700"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6270"/>
    <dbReference type="OrthoDB" id="1510342at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="85"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="159"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="47"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH87124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="253" mass="26996" checksum="3C1073B4EBF86B27" modified="2015-07-22" version="1">MLFPVYWMVNVSLTRTGDMRADPPHWFPRNPTFAGYADVLRDQIPALTTSLGIGLGCVALTLAVAAPAAYSLARLRPRSVGAVGFLLLVAQMIPSVVMAIGFYAVYVRLGWLNSVWGLILADSTIAVPFGVMVLTAFMSGIPAELLQAARIDGAGTWRTFVSVVLPLSRNALLTVSLFAFLWAWSDFVFASTLSRNADAIPITLGIYQYIGNNTTEWNSIMATAVVASVPAAVLLVIAQRFVAGGVVAGAVKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NI72</accession>
    <name>A0A0F7NI72_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ATP-grasp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_00750</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_00750"/>
    <dbReference type="EnsemblBacteria" id="AKH86467">
        <property type="protein sequence ID" value="AKH86467"/>
        <property type="gene ID" value="AA958_00750"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_00750"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.170"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="2">
        <location>
            <begin position="121"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH86467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="425" mass="44142" checksum="2E9F513CB1D11C4D" modified="2015-07-22" version="1">MGTVGGERTVGVLYDAGSAGAAEVAAAARFCGAELFLVVDRASAHVRELLPVLTRRFALCDITGLDAHDAAMAVAVFVPDGLLTFSEHRMELTSVIAAALGIPYWHTPAVTGRLVDKLQQRRTFAEAGLDDLPFALVADAADLDAALDTVGLPAVLKPRRGAGGRLVHRLDSVSGARAAVAACADAAPGADLLVEALLPGDPGAAGAQWGDYVSVETAVHRRECQPLCVTGKFPLVEPFRERGSFVPHTLDASLAECAEDLAEAAIGALDISDGIVHTELKLTADGPRLIEVNGRLGGLVGDVVRRGSGFDLVAAAMRLALGLPVPDSPRFEGVTYQYTLLPPARGTRQRPAAGPEDLSARLDGLRHLPGVDLADLTTAAALPTDPRDGAGARLGYLQGRTADHAELARLATAIAELCRPVPGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NI98</accession>
    <name>A0A0F7NI98_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MerR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_01540</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019709.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_01540"/>
    <dbReference type="EnsemblBacteria" id="AKH86487">
        <property type="protein sequence ID" value="AKH86487"/>
        <property type="gene ID" value="AA958_01540"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_01540"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.339"/>
    <dbReference type="OrthoDB" id="1748559at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="2">
        <location>
            <begin position="32"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH86487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="182" mass="19238" checksum="E6248FF33FD30C0A" modified="2015-07-22" version="1">MYGHGAEPARRPQAASAAPDEVGYRGPAACAAAGITYRQLDYWARTGLVEPSVRPANGSGAQRLYGSHDVVVLKIVKRLLDAGVSLQSIRTAVRHLRAAEPAGLRRMTLISDGATVYECTSPDEVVELLQGGQGIFGIAVGVVWSDVQAALAQLHAEHIDTGETLVGQNAADELARRRSRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NIC7</accession>
    <name>A0A0F7NIC7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4185 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_02820</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019742.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_02820"/>
    <dbReference type="EnsemblBacteria" id="AKH86517">
        <property type="protein sequence ID" value="AKH86517"/>
        <property type="gene ID" value="AA958_02820"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_02820"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.603"/>
    <dbReference type="OrthoDB" id="875398at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025442">
        <property type="entry name" value="DUF4185"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13810">
        <property type="entry name" value="DUF4185"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519526" description="DUF4185 domain-containing protein" evidence="1">
        <location>
            <begin position="29"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4185" evidence="2">
        <location>
            <begin position="61"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH86517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="368" mass="39970" checksum="9ABB1C3DCDD98727" modified="2015-07-22" version="1">MSRARFLRTAAGAAVGGGVLLGTGRAAAEPAGAGRGGAPRDGRGAAAPEVTKIRDLTGPGITTAYRMEATDLGIPVRTPDGRMLFVFGDTFEEARVGGGWWRSPVALYSRTTNLDAGVTWSGAVGGAAAQQLWAYEHDNPVFSTVLPSDVITIGSTMYLHAMVNKGLGNVVWTEIWRSDDNGATWVHTGAKFAPDLHGGLFQLLTWAAGDDGFVYVFSTEFTRSKPVILQRVPAARIADPGAYEPWGYRNGAWAWGNPPTPVLEGRFGEMCLRPMAGKWILTWFNEADYRIDGILMDTPTSNLYEAHRRTLVWGGQWGNEDDSHVAQLYGGYVIPGSTPDNLHLAVSQWNTAEGWPYRVMQHRVRGFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NIH2</accession>
    <name>A0A0F7NIH2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein-export membrane protein SecG</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AA958_05680</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Involved in protein export. Participates in an early event of protein translocation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the SecG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_05680"/>
    <dbReference type="EnsemblBacteria" id="AKH86567">
        <property type="protein sequence ID" value="AKH86567"/>
        <property type="gene ID" value="AA958_05680"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_05680"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1189"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015450">
        <property type="term" value="F:protein-transporting ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004692">
        <property type="entry name" value="SecG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03840">
        <property type="entry name" value="SecG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01651">
        <property type="entry name" value="SECGEXPORT"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00810">
        <property type="entry name" value="secG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AKH86567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="62" mass="6528" checksum="5321ABE532B7DD6A" modified="2015-07-22" version="1">MMLVLMHKGKGGGLSDMFGGGMQSSVGGSSVAERNLDRITVVVGLIWFAIIVVLGLLMKFDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NIL6</accession>
    <name>A0A0F7NIL6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase type 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_08575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019872.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_08575"/>
    <dbReference type="EnsemblBacteria" id="AKH86617">
        <property type="protein sequence ID" value="AKH86617"/>
        <property type="gene ID" value="AA958_08575"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_08575"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1809"/>
    <dbReference type="OrthoDB" id="1515497at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="32"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="202" mass="21927" checksum="E11FDFE4665CF82D" modified="2015-07-22" version="1">MPDSDLTPYWNTNVARHPGILRAVPEGCRDALDVGCGDGLLARKLVARAERVTGIDNSPEMIATAREQAADRPGIDFVAGDFLTADLPAAGYDFICSVSAVHQMDFTAALARMRELLRPGGVLVVVGLAREESAGDWAVTVAAAPVVRAAKVLRRASFPTGMPFISPHMSYGEVRAEARHVLPGVRYRRHVLRRYSLTWHAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NIV2</accession>
    <name>A0A0F7NIV2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Riboflavin biosynthesis protein RibD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_32610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020634.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_32610"/>
    <dbReference type="EnsemblBacteria" id="AKH87198">
        <property type="protein sequence ID" value="AKH87198"/>
        <property type="gene ID" value="AA958_32610"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_32610"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6888"/>
    <dbReference type="OrthoDB" id="1920912at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RibD_C" evidence="1">
        <location>
            <begin position="6"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH87198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="194" mass="21314" checksum="97CA6C1FF49B6434" modified="2015-07-22" version="1">MSNPIRLYMSMSLDGYIAGPDDRPGQELGRDGGRLFNWLDDRESDGPSGQVYREALATGAVISGRRTFELAGRWQGDHHDGVPILVLTHQVDDGDVPPGHARFVTDVEECARQARAAAGDRPVMVHGAGAAQALLRAGQIDEMEIHLVQVLLGGGRRLFDHLGGDHIELDLVRRLEDRDVTHLRYQVRRPGKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NIW9</accession>
    <name>A0A0F7NIW9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_14295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86757">
        <property type="protein sequence ID" value="AKH86757"/>
        <property type="gene ID" value="AA958_14295"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_14295"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3009"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021215">
        <property type="entry name" value="DUF2752"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10825">
        <property type="entry name" value="DUF2752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="146" mass="15758" checksum="55134D7328B50DC0" modified="2015-07-22" version="1">MARPRPAEGVRRRGAARVRRLLRRPATAPLALAAAGAAGAAYLYGTNPHEPGHWLPRCPFNWATGLDCPACGATRMAYDLLHGDLGSAFHSNALMLMLGLPFAAVLYGRWLYEGLRGRRWRPSFGRLGTAAVLGVAVVWAVVRNVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NK78</accession>
    <name>A0A0F7NK78_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_33520</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_33520"/>
    <dbReference type="EnsemblBacteria" id="AKH87212">
        <property type="protein sequence ID" value="AKH87212"/>
        <property type="gene ID" value="AA958_33520"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_33520"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.7079"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="119"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="192"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="251"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="82"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH87212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="285" mass="31100" checksum="AD2780CD17C86476" modified="2015-07-22" version="1">MRRAANRDSVPHAMRGSTGGRIGRGLLLTLAAVVTVFPFYAMVVLSLKPAAAVEFPGSLVPWPLGGEAYESVMNSQDVPRWLLNTLLYSLVSVVGVLLLSSLAGYAFAKKRFPGREAMFWSFLSMVMVPYHVTMIPTFAMIAKLGGVDTYWGLIVPTLANAQAVFLMRQFIQGLPDELFEAARLDGCGELQIFGRIVLPLLKPVLATLGVFVFLWHWNDFLWPLVIGQSTDMRTLTVGIASLQQQNVPLNVVLSGSVIAFVPIFAAYLVGQRYFTEGVTASGIKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MXA2</accession>
    <name>A0A0F7MXA2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidoglycan-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_00240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH80855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014222.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_00240"/>
    <dbReference type="EnsemblBacteria" id="AKH80855">
        <property type="protein sequence ID" value="AKH80855"/>
        <property type="gene ID" value="AA958_00240"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_00240"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.57"/>
    <dbReference type="OrthoDB" id="1597038at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.101.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036366">
        <property type="entry name" value="PGBDSf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="SSF47090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="22"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH80855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="294" mass="30859" checksum="2C59418C5F7E8047" modified="2015-07-22" version="1">MSRWKELPESLDPRVRQFVVQLRRLKDRSGLSLASLAGKTGISRSSWERYLNGKALPPPRAVEELTRVTGAEPTRLLVLRDVAAEAWRQQFTPDASARAEGADGAQAQSDAPAEQLATSTLPPAGDEGPPGVRKRLALTAVAVAALLGLGAGMLVATAWDDGGDGDGDGVAETVKEAADTRSPSPSSSPSPPADENGPYVFKAGKTYPCKVRRTDALNGRLGAGYSTTTTAVLAGPGWDVVEAQCLLDHHKLDPGPVDGVYGQQTIAAVAQLQKKNGLVADGIVGEHTWQVLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MXD1</accession>
    <name>A0A0F7MXD1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ferredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_00475</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH80890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014256.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_00475"/>
    <dbReference type="EnsemblBacteria" id="AKH80890">
        <property type="protein sequence ID" value="AKH80890"/>
        <property type="gene ID" value="AA958_00475"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_00475"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.111"/>
    <dbReference type="OrthoDB" id="1371190at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007419">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041854">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
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            <end position="360"/>
        </location>
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        <location>
            <begin position="411"/>
            <end position="460"/>
        </location>
    </feature>
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        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH80890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="478" mass="50982" checksum="40DD821C4EC0371D" modified="2015-07-22" version="1">MTATLPRPHDGVFDVAVIGGGIVGAAIARELSGYDLAVALLEARDDVGDGTSKANTAILHTGFDAKPGTLESELVARGYRLLGAYAEATGIPVERTGAILVAWTREELDALPGLKEKAEANGYEHCRIVGPDEVYRDLPDLGEGALGGLTVPDEAVICTWTTNLALATDAQRRGAALLLRHAVTGIDPGDEATVLHTAAGDVRARWVVNAAGLGADHVDRLLGHDRFTVTPRRGELFVFDKLARPLADKIILPVPSSRGKGVLIAPTVYGNVMLGPTAEDLTDRTATATSEEGFDFLLTKGARLMPRLLTEEVTASYAGLRAAIDHPDYLIETDPPQRYVLVGGIRSTGLTAGMAIAEHVRGLLADAGLAMRARETLPEPPRMPNIGEASPRPYQDADLIARDPAYGTLTCFCERVTEGEIRDACHTAVPARTLDGLRRRTRAMNGRCQGFYCGAAVAALYEQHHSHDGCHDHSGDDR</sequence>
</entry>
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                <person name="Winkler A."/>
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                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5 6">CNQ-509</strain>
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        </location>
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        </ligand>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS50893"/>
        </source>
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            <dbReference type="EMBL" id="AKH81240.1"/>
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</entry>
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        <lineage>
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                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000034283">
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        </location>
    </feature>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
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</entry>
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    <accession>A0A0F7MZE0</accession>
    <name>A0A0F7MZE0_9ACTN</name>
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        <lineage>
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                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Robl_LC7" evidence="1">
        <location>
            <begin position="17"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
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            <dbReference type="EMBL" id="AKH81081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="140" mass="14581" checksum="5F5FA71016395217" modified="2015-07-22" version="1">MVVQGGNRRHPAGGRLNWLLDDLVGRLASVRMALVLSSDGLPMSVSEDVSREDSEHLAAVASGIHGLAKGVGTHFEAGSVRQTLVELDDAFLFVTAAGDGSCLAVMAASDADIGQIAYEMTLLVKRVGEHLAAAPRGSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-12-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MZY1</accession>
    <name>A0A0F7MZY1_9ACTN</name>
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        <submittedName>
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    <organism evidence="4 5">
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                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="3">
        <location>
            <begin position="6"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="137"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="81"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH81261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="165" mass="18219" checksum="0F2257EF3B1BC450" modified="2015-07-22" version="1">MKSDESMTIGELAGRFGLAAHVLRHWEAMGLLTPAERVNGRRRYTSDHVSRVAMIIGGKRGGLSLEQLRELFAAQGPGDRHALLARHREELQERMREIERSKAMIDHALECEAHDFTRCPTFQALVRRLAAGESLAQLPVGTGPSAGRDPQEPHVRGGPNGTVIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0N5</accession>
    <name>A0A0F7N0N5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_00580</name>
    </gene>
    <organism evidence="1 2">
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        <lineage>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH80909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_00580"/>
    <dbReference type="EnsemblBacteria" id="AKH80909">
        <property type="protein sequence ID" value="AKH80909"/>
        <property type="gene ID" value="AA958_00580"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Squ/phyt_synthse"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH80909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="337" mass="37729" checksum="1A38002D3B33B3B5" modified="2015-07-22" version="1">MFAHELSAAGLRGTEAGAAYAACGRYVRRRNSAAFPIARFLLPPGKRPYYDAILAFCGYAGDVLDTTEQGMHERAERFDALRHEALRRIDPGTAATAGTGAGPVTAEAVLICRALAHTVRTWDMDPEGIRRFLRTLRTDLDTSSYATFEDLELHMRSVSGDMSIWVNALLEPVDEEATVKAIALGYGVYMLDFLDDIAEDALLGRVYLPLADLERHGLGREDLTTAAARQRMTPSLREAVRFEADRIRRFFRLADGWHRHVHPSGQELPRQYLELGRTVLAEVVRDDYDIFQRRRSTRLLCTARAGGTTARSYLRTLRHRRAHPPRIPGVPARRAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0Q7</accession>
    <name>A0A0F7N0Q7_9ACTN</name>
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        <submittedName>
            <fullName evidence="2">Urea carboxylase-related aminomethyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_01045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AKH80988">
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    </dbReference>
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    <dbReference type="OrthoDB" id="969451at2"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <feature type="domain" description="DUF1989" evidence="1">
        <location>
            <begin position="10"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH80988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="208" mass="21895" checksum="77AA5F0C6E19CFAD" modified="2015-07-22" version="1">MTSTIVASLTVPARGAEAFHIATGQRMRITDPEGGQVGDLFAYSADDPTEHLSASHTRAATARLFPAPGEQFFTTRRRPILTLVEDTSPGRHDMLIPACDPERYRALGASGHASCAENLSTALARHGMYADTVPQPVNVFMDVRPTARELTWHAASTRPGDAITFEAAMACLVVLSACPQDLAPVNSGPTTALSVTVLAADSPTPVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0S0</accession>
    <name>A0A0F7N0S0_9ACTN</name>
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        <submittedName>
            <fullName evidence="5">Aldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_04595</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
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        <property type="protein sequence ID" value="AKH81591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_04595"/>
    <dbReference type="EnsemblBacteria" id="AKH81591">
        <property type="protein sequence ID" value="AKH81591"/>
        <property type="gene ID" value="AA958_04595"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_04595"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.969"/>
    <dbReference type="OrthoDB" id="618655at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
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        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
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    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="4">
        <location>
            <begin position="13"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH81591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="472" mass="48200" checksum="4D61AC9795A11353" modified="2015-07-22" version="1">MQAHDGMFIDGRWQPAAGDGVIEVVDPADEQVIATVPAGTAADVDAAVAAARAAFPRWAATPPADRAARVGALGDVLAARAEDIAATVTAELGAPLTFSRKVHAAVPVAVSASYARIGASYPYEEKAGTATVLHEPVGVVGAITPWNYPLHQIVAKAAPALAAGCTVVLKPAENTPLVARIFAEAVAAAGFPPGVLNVVTGYGAEAGRALVEHPGTDFLSFTGSTAVGRTVAAAAGAAVKPVALELGGKSANVILPGADLARAVSAGVANVMANSGQTCTAWTRMLVHRDAYDEALTLATTALTKYAPGDPRDPATRLGPVVSSVQRERVRGYIERGTAEGAVLLAGGPGAPEGRERGYYVRPTVFADVTPGMTIAQEEIFGPVLAIMPYEDEDDALRIANGTVYGLAGAVWAASDAEAAAFARRMETGTVVVNGGKFDPLAPFGGHKQSGIGRELGVAGLAEFLHTKSLQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N109</accession>
    <name>A0A0F7N109_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_01675</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014452.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_01675"/>
    <dbReference type="EnsemblBacteria" id="AKH81088">
        <property type="protein sequence ID" value="AKH81088"/>
        <property type="gene ID" value="AA958_01675"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_01675"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.367"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
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    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAC" evidence="2">
        <location>
            <begin position="175"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH81088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="481" mass="50787" checksum="19827E82FB0E2110" modified="2015-07-22" version="1">MAAASRLPRAAGPHAPEQPERSPVATLLAQIARLRGSLEAVQRETIAAAGDAQGAELRWQRALCDLAARQLDSLTLQLGQLRAGHPVDADREDGEGPAGEFPAGPLDRPQPRVGSAEWHLLSDIVDWSDDLFDIFGRDPGDGPLSLDELPSWFDPADQPRLTAMVTDCLVDGKPIDGEFRIRRPDGAPRTLHVVGEPVLDAGGATESMWTVVRDVTELRRSRQAVRESESALQRERHFAAAERRIARELHESVLPPWRGAVHLPAGDPAALTVAGHHFPAAADTPVSGVWYDALPLPGGDTFLGVGDVAGRGVPAAAGMTMLLGALRGMALGGADPAALLGRANELLEVSAQPVLVGTVCCRYDPAARTLRWARAAHVSPLLFRDGAGRPLTAPEGVLLGATADTSYAQVSEVLQPGDLLLLHTAALGARSPEPARERLLALAPRLAAAPGAQECLRTVVEEFGGGRRGDDACVLVARVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N138</accession>
    <name>A0A0F7N138_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_01655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014448.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_01655"/>
    <dbReference type="EnsemblBacteria" id="AKH81084">
        <property type="protein sequence ID" value="AKH81084"/>
        <property type="gene ID" value="AA958_01655"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_01655"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.363"/>
    <dbReference type="OrthoDB" id="1533486at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="300" mass="31377" checksum="138F8E555B5B11F3" modified="2015-07-22" version="1">MTPDPATAPGTAAATGSADGHPPAVTPADAADAARLVSFGLQPKLLPARDLEYGELLRRYREDPPFARLADAVATGLGLVVLEVSARTGMAVTASEDSVFAVRMGDYARRAATDSADRFLHGLAHLAVAAMAFPRPEDLADDGYIGRVSVNGVDAFVRQACRRLEERAEEAGENTDPAEGERGLEAAWRVYARRSATGATKDARRLAGSTTGIIGKAMAFLTDSGFLQRTSDDAGGTYRTTARYQLQVRDMAGGAAMSELLELGVVPVADGSATLVPAADDDGEIAGGALPFFPSQHERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N1E8</accession>
    <name>A0A0F7N1E8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glycosyl hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_02650</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014616.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_02650"/>
    <dbReference type="EnsemblBacteria" id="AKH81253">
        <property type="protein sequence ID" value="AKH81253"/>
        <property type="gene ID" value="AA958_02650"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_02650"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.566"/>
    <dbReference type="OrthoDB" id="32528at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd14490">
        <property type="entry name" value="CBM6-CBM35-CBM36_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011635">
        <property type="entry name" value="CARDB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033801">
        <property type="entry name" value="CBM6-CBM35-CBM36-like_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07705">
        <property type="entry name" value="CARDB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00231">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519065" evidence="4">
        <location>
            <begin position="35"/>
            <end position="1357"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="5">
        <location>
            <begin position="29"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="5">
        <location>
            <begin position="165"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="6">
        <location>
            <begin position="320"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="5">
        <location>
            <begin position="421"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="187"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="388"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="194"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH81253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="1357" mass="141455" checksum="894DC673F3F0832E" modified="2015-07-22" version="1">MRKHRSRHRPTVAALATGLLLFGLPALPALPAVAATGSDAAAGRPAAASSAAPRHAAAEVTDGDQDTYWQSRGTGAQWVQTDLRRRARVDEVVLRLPADASARKQTLAVQGSADGTTFHTLSAEDTRAFRPAADNTVTVRFPASLTRYVRVQFAGTTAERPARLAELTVHTAADGAADLAAGRPLLASSHTGDRTADRAGDGDRDSFWQSGKSKREQWLRTDLGATVGIDRAVLKLPEGGAARVQNLKLQGSTDGREFTDLTAARDIAFGSSGGHSATLSFDTAVTRHVRVVFTAGTGSARLAELEVYGPAEGDTRPPGTPRDLTRTALPDGRVQLDWRPPAGGADDLDGYDVYADGRLRTGVGADVTTYVDTPAPGDSVTYRVRARDTAGNQSPDSAKVAVRARPSATATAEPAAPDPGTAAATAAAADPDLAGGKPITASSHVHNFVATNANDGNRGTYWEGAGGAYPGTLTVELGANADVSAVVVQLNPDPVWGPRTQTFSVLGREQDATSFTTLKAGAQYAFDPATGNSVTVPVTGRVADLRLSFTANTGASAGQVGELQVLGTAAPNPDLEITGLTPTPASPDETQSVTLAATVHNAGGEPAAATGVDFLLGGEPAGTADVGTLAPGATRTVTANTGAHDAGEYALAAVVDPDDTVVEQDEANNEYTAPTPLRVSPVQSSDLVASVGWTPSSATGGERVDFSVTLKNQGTQASASGSHPITLTLRSASGGTVTTLNGAHNGTIAAGATTAPVGLGRWTAANGSYTVEVTVAADANEVPVKRENNTSTESLFVGRGADMPYDTYEAEDGAVAGGAQVVGPNRTIGDVAGEASGRRAVTLDQTGESVEFTTKSSTNTLVTRFSIPDAPGGGGIDATLNVYVDGTFHKAISLTSTYAWLYGAEAAPGNSPGAGPARHIYDEANLMLDRTVPAGSKIRLQKDAANTTSYAIDFVSLEQVAPKANPDPAAYTVPAGVTHQDVQNALDRVRMDTTGQLKGVYLPPGEYQTSSKFQVYGKPVQVVGAGPWYTRFHAPAGQQNTDVGFRAEQAAAGSSFRGFAYFGNYTSRIDGPGKVFDFQNVSDITIDDIWNEHMVCLYWGANTDDITIGNSRIRNSFADAINMTNGSTGAHVVNNESRATGDDSFALFSAIDAGGSDMHSNVYENLTSLLTWRAAGIAVYGGYNNTFRNIRIADTLVYSGVTVSSLDFGYPMNGFGTQPTTLENITIERCGGHFWGAQTFPGIWLFSASKVFQGIRINNVDITDPTYSGIMFQTNYVGGQPQFPIKDTILTDITVSGARKSGDALDAKSGFGLWANEMPEAGQGPAVGQVTFRNLTLRNNAQDVKNTTSTFTIDIQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N1I6</accession>
    <name>A0A0F7N1I6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fe-S oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_09575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015779.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_09575"/>
    <dbReference type="EnsemblBacteria" id="AKH82435">
        <property type="protein sequence ID" value="AKH82435"/>
        <property type="gene ID" value="AA958_09575"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_09575"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2018"/>
    <dbReference type="OrthoDB" id="970297at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023862">
        <property type="entry name" value="CHP03960_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045784">
        <property type="entry name" value="Radical_SAM_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19864">
        <property type="entry name" value="Radical_SAM_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03960">
        <property type="entry name" value="rSAM_fuse_unch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Radical SAM core" evidence="1">
        <location>
            <begin position="266"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="655" mass="72932" checksum="C7F85A5E0853A422" modified="2015-07-22" version="1">MTAVPAPTVESVFPRLEALLPHVQKPIQYVGGELNSTVKDWDAVDVHWALMYPDAYEVGLPNQGVMILYEVLNERADTLAERTYSVWPDLEELMRAHDVPQFTVDSHRPVRAFDLLGVSFATELGYTNLLTALDLAGIPLAAADRGDDDPIVVAGGHAAFNPEPIAAFVDCAVIGDGEQAVLTMTDIVKAWKAEGRPGGREELLLRLAKTGGVYVPSFYDVEYLPDGRIARVVPNRSGVPWRVSKHTVMDLDEWPYPKQPLVPMAETVHERMSVEIFRGCTRGCRFCQAGMITRPVRERSITGIGEMVDRGLKATGFEEVGLLSLSSADHSEIGDVAKGLADRYEEDKVGLSLPSTRVDAFNIDLANELTRNGRRSGLTFAPEGATERIRKVINKMVSEEDLIRTVATAYGNGWRQVKLYFMCGLPTETDEDVVQIADMAAKVIAKGREVARSNDIRCTVSIGGFVPKPHTPFQWAPQLSAEDTDARLEKLRDRIRADKRHGRAIGFRYHDGKPGIVEGLLSRGDRRVGDVIRAVYEDGGRFDGWREHFSYERWMRSAEKALPAHGVDVDWYTTRERSYEEVLPWDHLDSGLDKDWLWEDWQDALDETEVEDCRWTPCFDCGVCPQLDTEIQIGPTGKKLLPLSVVNGPTGGNEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N1M0</accession>
    <name>A0A0F7N1M0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_09770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015813.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_09770"/>
    <dbReference type="EnsemblBacteria" id="AKH82470">
        <property type="protein sequence ID" value="AKH82470"/>
        <property type="gene ID" value="AA958_09770"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_09770"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2059"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="67" mass="6991" checksum="4FFFBA1B1ECAC985" modified="2015-07-22" version="1">MSMAVVGMVAGMAAGFAGYFGGFGAFIVVVVLGLIGFFLGRFADGDLELGDFFGTRGGSGDRFDRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N1Q3</accession>
    <name>A0A0F7N1Q3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">zf-CGNR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_10075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015857.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_10075"/>
    <dbReference type="EnsemblBacteria" id="AKH82515">
        <property type="protein sequence ID" value="AKH82515"/>
        <property type="gene ID" value="AA958_10075"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_10075"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2121"/>
    <dbReference type="OrthoDB" id="1770002at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010852">
        <property type="entry name" value="ABATE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023286">
        <property type="entry name" value="ABATE_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021005">
        <property type="entry name" value="Znf_CGNR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35525">
        <property type="entry name" value="PTHR35525"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07336">
        <property type="entry name" value="ABATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11706">
        <property type="entry name" value="zf-CGNR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160904">
        <property type="entry name" value="SSF160904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-CGNR" evidence="1">
        <location>
            <begin position="136"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="185" mass="20263" checksum="B96B6C6DD921A902" modified="2015-07-22" version="1">MAVSDYTGQAALTAVDLVNSLDVITGRDRLRDGEDAAALLARHHWDVGRAVSAADLERLRRLRPRLRFVFGGTPVQKSVADLNALLRDLRAQPHLTDHDGAWHWHYARPRAPLGERVATSCVVALLTAIADGGAGRLRICDGADCANVFVDASRPGLRRYCDTKSCGNRAHVTAYRERKRTRSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N1V4</accession>
    <name>A0A0F7N1V4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_00125</name>
        <name evidence="3" type="ORF">AA958_34130</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH80837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014204.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_00125"/>
    <dbReference type="EnsemblBacteria" id="AKH80837">
        <property type="protein sequence ID" value="AKH80837"/>
        <property type="gene ID" value="AA958_00125"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86434">
        <property type="protein sequence ID" value="AKH86434"/>
        <property type="gene ID" value="AA958_34130"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_00125"/>
    <dbReference type="KEGG" id="strc:AA958_34130"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.28"/>
    <dbReference type="OrthoDB" id="1513550at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039650">
        <property type="entry name" value="HdrA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43498">
        <property type="entry name" value="PTHR43498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="423"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH80837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH86434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="450" mass="47416" checksum="F7E51E7E1ABD37A9" modified="2015-07-22" version="1">MREDLDVLVVGGGPAGICAAAQAAGLGARTGLVEKNGALGGTTTVAGVALPGLFHAWGHQIIAGIGWRLVREAAAVGGTALPDFSRWDLPHYRLQVPVNPAVYAALADRTVLVSGAEPLLHTMVAEAEWTDSRWRVVLCGKEGLREVWAGRLVDCTGDADVVALAGLARRRNPRQQPGTLMVRFGGYDHLAVDDLDLAALDRAYDAALAEGVLRAEDFQSAVHPLGKLLRHRGENAIHVTGVDGGTSDTRTQAELAGRRALLRIFRFLRAQPGLEGLTIDSWAVETGIRETFTIDGLARVTVDDYRGGRLWDDAVSYSFYPIDVHRSDGDGVDIRPLDYGVLPTIPRDAMVPRDGPGALLVAGRSVAGDQEANSAYRVQASCMATGQAAGTVAALSAATDTPVQDVPVAAIHRTLRATGAIVPGDVTVAPRPPTGPVGPTPPSRPAPPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N229</accession>
    <name>A0A0F7N229_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_07260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015406.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_07260"/>
    <dbReference type="EnsemblBacteria" id="AKH82056">
        <property type="protein sequence ID" value="AKH82056"/>
        <property type="gene ID" value="AA958_07260"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_07260"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1521"/>
    <dbReference type="OrthoDB" id="1498048at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH82056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="202" mass="20805" checksum="660F603F6DC46A6C" modified="2015-07-22" version="1">MDAVRVALLREVLAGTEWPGAARRFAGVLRGAVEAQGGGLLLVGTAAYEPWHLAAHLDDEAAWSGLPALSPTLVRHRVPASGPAHLGVGLGRLEAAGRRETLLVVAPDEPGDALLERVGDARRAGAAVLVLDGGSAELPGLAHELLTVPGDSGDIDLETVQHLVSAAAGENGDPPAASARSGFRHRLARLAEVLSSPPPPRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2J8</accession>
    <name>A0A0F7N2J8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">OmpR/PhoB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_04700</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AfsR/DnrI/RedD regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014964.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_04700"/>
    <dbReference type="EnsemblBacteria" id="AKH81609">
        <property type="protein sequence ID" value="AKH81609"/>
        <property type="gene ID" value="AA958_04700"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_04700"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.991"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15831">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042197">
        <property type="entry name" value="Apaf_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03704">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="563"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="801"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1087"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="801"/>
            <end position="832"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH81609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="1118" mass="118806" checksum="3D3DEA8D0998DB87" modified="2015-07-22" version="1">MRYRVLGRLDVCNGTRRITLNAAKQRALLAHLLINAGRFVPADALITELWGDDVPDSAAKSLQVYVHRLRRALGGDPETLHTRPGGYELGIEPDGTDAARFATLAAAGRAELADRRPAAAVETLTEALGLWRGPAFADVPATDAVRAEAARLEENRLTAWEDLADAKLAVGRHPELAAELGALLAQHPLREPLWGRLMLALHRAGRRSDALRTYARARRTLADELGVEPGAQLQEVHAAVLAGGPEPAPRPEAAERPAYCQLPARIPDFVGRREQLVQVLRWLGQPEGAADREAPGLDAWQVDARHPAPRTVLVTGVAGAGKSTFAVHAAHLLRDAFPDGQLHADLRTAAGHPADTGDVLASLLKTLGMTGAGIPESLEERVRRYRAEIADRRVLVVLDNAGCERQIRPLLPGTGDSAVLVTSRAALAGLEGALRVELGLLSDAEALELLARAAGDDRTRRDPAVATRIAAQCGNLPLALRIAGARLATRRHLSLPRLADALADERRRLDELVAGDLEVRASVTLGYAALDPAAQRAFRLLGLLDVPTVPGWVVAALLGDAPAGTDEDGRAGDGVGGDGTAGGDTVRGARPAADPTALAERSLDALVDNHLVEVHTAEPAAEPRYRLHDLLRLYARERAHAQEPPAERAAALGRVHTAYLDLARRADDALSSGFSGRVQAPAPGHSPPAAEAARVAAEPLAWLEAERTTLRALVRQAADAGEAGTAWRLAAALAAFFETSAHFDDWRETHRTALAAATAAGDRLGVAVLHRNLGELETVQDHYGEAVVAFKRSLKEFAALDRPRALPRAKPGDRPRDPARGPARDGRQDTGGHHPAESAAAAGLGVLLRLRGQYAQAAACLRRGIERARAGGNVRSEAYARCGLGTVHLECGEPGAARREFDLALALAQQDGYRHGEASAERNLGLADLAVGRVHAAAARMLRSCELAVESGDRVGEVHALQWLGHLTDVAGEPARAERMLDESLAAYRRFGERFGEALTLRAQADLLLHAHRPAEAKATARQALSIWRHLDTPYWTSRTLDVLAAAHAAAGGAGGEVAAARVRRQASALRASVGLPAALRAPVAAGRRLGGHLTPPPEPPPSFRTPRDPLRVAAESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2R7</accession>
    <name>A0A0F7N2R7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_01960</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014501.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_01960"/>
    <dbReference type="EnsemblBacteria" id="AKH81137">
        <property type="protein sequence ID" value="AKH81137"/>
        <property type="gene ID" value="AA958_01960"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_01960"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.423"/>
    <dbReference type="OrthoDB" id="1688736at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="227"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="274"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="85"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH81137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="306" mass="33710" checksum="32E2458596B4FB67" modified="2015-07-22" version="1">MPLVNHARRTRRRGPRRFTARDLAVIGVLLGFAILLDLFIIWGPTVASITLSFSSWDGLSDLSWVGGDNYDTLAGGDYPPFWPAVRNNLLWIAFLGLVATPFGLLLAVVIDRGVRFSRFYQSTIYLPVVLSLAVVGFIAQLIFSRDQGALNAILGNENNPTDWLGDRDLNIWMVLLAAGWRHTGYVMILYLAGLKAVAPELKEAAAIDGANERQTFLRVVFPTMRPVNVVVLVITVIEALRAFDIVYAINKGRNGLELLSVLVTDNIIGEASRIGFGSAIAVVLLTVSLGFIVTYLVQEMRGEEHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N347</accession>
    <name>A0A0F7N347_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7 8">2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase</fullName>
            <shortName evidence="7">MECDP-synthase</shortName>
            <shortName evidence="7">MECPP-synthase</shortName>
            <shortName evidence="7">MECPS</shortName>
            <ecNumber evidence="3 7 8">4.6.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ispF</name>
        <name evidence="10" type="ORF">AA958_13455</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7 8">
            <text>4-CDP-2-C-methyl-D-erythritol 2-phosphate = 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + CMP</text>
            <dbReference type="Rhea" id="RHEA:23864"/>
            <dbReference type="ChEBI" id="CHEBI:57919"/>
            <dbReference type="ChEBI" id="CHEBI:58483"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="4.6.1.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="7">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 4/6.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the IspF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.12" evidence="3 7 8"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016401.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_13455"/>
    <dbReference type="EnsemblBacteria" id="AKH83070">
        <property type="protein sequence ID" value="AKH83070"/>
        <property type="gene ID" value="AA958_13455"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_13455"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2829"/>
    <dbReference type="OrthoDB" id="1716560at2"/>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008685">
        <property type="term" value="F:2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00554">
        <property type="entry name" value="MECDP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00107">
        <property type="entry name" value="IspF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003526">
        <property type="entry name" value="MECDP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020555">
        <property type="entry name" value="MECDP_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036571">
        <property type="entry name" value="MECDP_synthase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43181">
        <property type="entry name" value="PTHR43181"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02542">
        <property type="entry name" value="YgbB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69765">
        <property type="entry name" value="SSF69765"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00151">
        <property type="entry name" value="ispF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01350">
        <property type="entry name" value="ISPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 8" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="6 7 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YgbB" evidence="9">
        <location>
            <begin position="23"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="4-CDP-2-C-methyl-D-erythritol 2-phosphate binding" evidence="7">
        <location>
            <begin position="29"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="4-CDP-2-C-methyl-D-erythritol 2-phosphate binding" evidence="7">
        <location>
            <begin position="56"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="4-CDP-2-C-methyl-D-erythritol 2-phosphate binding" evidence="7">
        <location>
            <begin position="78"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="4-CDP-2-C-methyl-D-erythritol 2-phosphate binding" evidence="7">
        <location>
            <begin position="151"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>4-CDP-2-C-methyl-D-erythritol 2-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57919"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AKH83070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="178" mass="17461" checksum="2510417CBA92C5D1" modified="2015-07-22" version="1">MPSDASGHAAEAGAAGPYGVLPRIGVGTDVHAFAEGRELWCAGLLWEGESHGLDGHSDGDVAAHAACDALFSAAGLGDLGAHFGTDRPEWSGAAGVALLGEAARIVRASGFHVGNVAIQVIGVRPKIGKRRAEAQEALSAAAGAPVSVSGTTTDGLGLTGRGEGLAAIATALLLPPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3F6</accession>
    <name>A0A0F7N3F6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DksA C4-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_06485</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015267.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_06485"/>
    <dbReference type="EnsemblBacteria" id="AKH81914">
        <property type="protein sequence ID" value="AKH81914"/>
        <property type="gene ID" value="AA958_06485"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_06485"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1354"/>
    <dbReference type="OrthoDB" id="1932026at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037187">
        <property type="entry name" value="DnaK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020460">
        <property type="entry name" value="Znf_C4-type_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000962">
        <property type="entry name" value="Znf_DskA_TraR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020458">
        <property type="entry name" value="Znf_DskA_TraR_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01258">
        <property type="entry name" value="zf-dskA_traR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00618">
        <property type="entry name" value="DKSAZNFINGER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109635">
        <property type="entry name" value="SSF109635"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01102">
        <property type="entry name" value="ZF_DKSA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51128">
        <property type="entry name" value="ZF_DKSA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005181873" description="DksA C4-type domain-containing protein" evidence="6">
        <location>
            <begin position="16"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="DksA C4-type" evidence="7">
        <location>
            <begin position="228"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="dksA C4-type" evidence="4">
        <location>
            <begin position="271"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="160"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH81914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="302" mass="31249" checksum="93B344DE2FA7E1F2" modified="2015-07-22" version="1">MVAKKTAPAAKKSTAKKTTAKQAAKKAPVRKAAAGRSTAPEERAAKKQAAKKVTKKAAKKTTKKATKKTAGKKTAATAEAAGAAVPAGKSPRAKKAAARKAPAAGTEPARKTAARAAAPARKPAKKAAAKKTSARTSPGKKTGAKTVVAKKTQVVETSVAEAAGGTAAPAEPGELAVRPGEDPWTPEEIEEARQGLLDEVASLRSEIRASEEAVSGLMRDSGGGAGDDQADTGTKNISREHEMALAAGARERLVQTERALVRLEDGTYGRCESCGKPIGKARMQAFPRATLCVECKQRQERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3F8</accession>
    <name>A0A0F7N3F8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aspartate carbamoyltransferase</fullName>
            <ecNumber evidence="5">2.1.3.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Aspartate transcarbamylase</fullName>
            <shortName evidence="5">ATCase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">pyrB</name>
        <name evidence="10" type="ORF">AA958_03130</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>carbamoyl phosphate + L-aspartate = H(+) + N-carbamoyl-L-aspartate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20013"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:32814"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="EC" id="2.1.3.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.2" evidence="5"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014697.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_03130"/>
    <dbReference type="EnsemblBacteria" id="AKH81337">
        <property type="protein sequence ID" value="AKH81337"/>
        <property type="gene ID" value="AA958_03130"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_03130"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.667"/>
    <dbReference type="OrthoDB" id="1844275at2"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00116"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004070">
        <property type="term" value="F:aspartate carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1370">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00001">
        <property type="entry name" value="Asp_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006132">
        <property type="entry name" value="Asp/Orn_carbamoyltranf_P-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006130">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036901">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002082">
        <property type="entry name" value="Asp_carbamoyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006131">
        <property type="entry name" value="Asp_carbamoyltransf_Asp/Orn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405:SF16">
        <property type="entry name" value="PTHR11405:SF16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00185">
        <property type="entry name" value="OTCace"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02729">
        <property type="entry name" value="OTCace_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00100">
        <property type="entry name" value="AOTCASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53671">
        <property type="entry name" value="SSF53671"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00670">
        <property type="entry name" value="asp_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00097">
        <property type="entry name" value="CARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="OTCace_N" evidence="9">
        <location>
            <begin position="3"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="OTCace" evidence="8">
        <location>
            <begin position="159"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="314"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AKH81337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="335" mass="35975" checksum="EC867390ABCEBE98" modified="2015-07-22" version="1">MKRHLISAADLSRDDAVLILDTAEELARIADRPIKKLPTLRGRTVVNLFYEDSTRTRISFEAAAKRLSADVINFSAKGSSVSKGESLKDTALTLEAMGADAVVIRHHDSGAPHRLATSGWINGSVVNAGDGTHEHPTQALLDAFTMRRHLAPGTGGGLDGRRITVVGDILHSRVARSNVLLLHTLGAEVTLVAPPTLVPVGVESWPCEVSYDLDAVLPKSDGVMMLRVQRERMNAAFFPTEREYARRYGLDGDRMARMPEHALVMHPGPMNRGMEITAEVADSPRCTAVEQVANGVSIRMAVLYLLLGGAPGEAPAAAPAATPAPTTARTEETDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N436</accession>
    <name>A0A0F7N436_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_15655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016717.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_15655"/>
    <dbReference type="EnsemblBacteria" id="AKH83405">
        <property type="protein sequence ID" value="AKH83405"/>
        <property type="gene ID" value="AA958_15655"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_15655"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3300"/>
    <dbReference type="OrthoDB" id="670484at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="534"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="534"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="572" mass="62591" checksum="589AA4A5E91D7AE5" modified="2015-07-22" version="1">MIAKIMKPGHSTRNTIAYLYKTGRSHDHTDPHLVAAWDELVPDPGRTDNPGQALAQLVQALDLRVKQAGDRAEKGHVWHCAIRAAPEDPILTDEQWAQVARRIVHATGIAPAADPDGCRWIAARHAPDHIHIVATKMRGDLRRPRHWNDYHRADTELAKIETEWGLRAYDRGDRTAAKRPTRAETEKATRRTGNPITPREKLRATVRTAAAHAQDEDHFFALLTGADILVDKRIAPSGDAIGYKVALTGDTNAAGDPVWFPGGKLAPDLSLPKIRARLTSQPSDAPATHRAHPAERWRQTTAALRDAHRTLYEGGNPSAAQAELAAAGELLDILPALTTGPVRRELFATAQTFERATRSRIRFDYAQAAGLRTSAKHLLRTAGQPIPDAAALDLILTLTLLTIAAAHWHRANRHTQQAAAAQGALPHLRAAYRHTAAPALNNFAQRAPAPEAADRYSALVRGALPEYAEQILTDGSWPALAATLHEAEAEADGHRPADALTKAADSRELDTADSVAEVLIWRVHNIAGMQARWAEGAQTTTRSRTEQRQVQAPDSQRLPTPSPSPERARRQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N437</accession>
    <name>A0A0F7N437_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SGNH hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_11635</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016112.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_11635"/>
    <dbReference type="EnsemblBacteria" id="AKH82776">
        <property type="protein sequence ID" value="AKH82776"/>
        <property type="gene ID" value="AA958_11635"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_11635"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2447"/>
    <dbReference type="OrthoDB" id="1247435at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519218" evidence="1">
        <location>
            <begin position="46"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH_hydro" evidence="2">
        <location>
            <begin position="243"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH82776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="447" mass="46432" checksum="06DEE3E01701A875" modified="2015-07-22" version="1">MPQPAYRRPRDRRAAVYPYLAAALVVALVAAVAVAANVLRGPAPAAAGTPAAPGGPAQWVASWTSMPQLTEPANMPPPPFTQDDGVLRDATLRQTVRLAVPGERLRFRFSNAFGGAELPITRAAVALPAGGRAGVDGIVPGSSRPLTFGGRTGATVPVGAQVVSDPVRLDAAPGANLTVTLYLADGQASTAVTSHPGSRTTSYLLAGDHTGAAALPGATATDHWYFLSGVEAQAPARTRSAVVLGDSLSDGRGSTTNGNDRWPDVLNDRLRGPGAPPVAVVNQAAGGNRVLDDGLGPNALARLDRDVLAVSGARWLLVFEGINDIGTAPATEAAQRATGDELLAAYDQIVTRAHAQGIRVYGATLTPFGGSTPYDDPAGLREATRQRVNDWIRSSGRFDAVVDFDAATRDPAHPRALLPALDTGDHLHLNPEGYALLARAVPLRLFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N486</accession>
    <name>A0A0F7N486_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Arsenic ABC transporter ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_11915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016157.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_11915"/>
    <dbReference type="EnsemblBacteria" id="AKH82821">
        <property type="protein sequence ID" value="AKH82821"/>
        <property type="gene ID" value="AA958_11915"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_11915"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2506"/>
    <dbReference type="OrthoDB" id="1225869at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025723">
        <property type="entry name" value="Anion-transp_ATPase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016300">
        <property type="entry name" value="ATPase_ArsA/GET3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10803">
        <property type="entry name" value="PTHR10803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02374">
        <property type="entry name" value="ArsA_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00345">
        <property type="entry name" value="GET3_arsA_TRC40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="8"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="336" mass="36354" checksum="9E1B69115832AD1F" modified="2015-07-22" version="1">MLLDLLSSRRVVFVGGKGGVGKTSVAAALALGRARAGARVLLVSTDPAHNLGHLWERPVGDEPVRLASRGDLAHRVRAGTAGHVDGLEIDPERTVEQHLSAVAETMRRLLPERIHASARRHLELARQAPGTHESAVLERIAEAVELGEEAYDLVVFDTAPSGHTLRLLALPEQLTSWTETLLANRDRSERFGAAVRGLGGGAETDRDAELRRILVRRRNRFSRLREVVTDSEQTGFVVVLTAELLPIAETIEVYQKLTGLGIDVAALVANRRSPSDAGELLARRRRTEDEHLVRLRRQLPDVPLLDVPLLPGDLVGAEALAALAGRLGPSSSGFSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4N9</accession>
    <name>A0A0F7N4N9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NUDIX hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_09060</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015700.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH82353">
        <property type="protein sequence ID" value="AKH82353"/>
        <property type="gene ID" value="AA958_09060"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_09060"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1909"/>
    <dbReference type="OrthoDB" id="1345242at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="4">
        <location>
            <begin position="5"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH82353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="159" mass="17320" checksum="5294BD7189474370" modified="2015-07-22" version="1">MVDTTHRPAARVICLDAAQRILLLRWRDPFDGALIWEPPGGGIEPDETPLAAARRELAEETGLDPAAVAERGVPVARDFHWKGTHFVGTEHFFLARYPDDRPPLRRTGLLPDEQATLAGHAWIAWPDIPALPDPLEPPHLKAVLADLAPDGPWSSAAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N521</accession>
    <name>A0A0F7N521_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_13660</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016436.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_13660"/>
    <dbReference type="EnsemblBacteria" id="AKH83106">
        <property type="protein sequence ID" value="AKH83106"/>
        <property type="gene ID" value="AA958_13660"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_13660"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2875"/>
    <dbReference type="OrthoDB" id="1329670at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH83106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="317" mass="33442" checksum="9E7A69A351C6E0E1" modified="2015-07-22" version="1">MTFPDGTSGPQAADDPPTTRLTPIRPDTRPPGASSYGTFGSPAQGAYGSTAQGTYGSTAAAAGPAPEAGGRARRRGKRTALLLAAAVLAGALGGVAYGYFEQAGNPPTPLPPLNQPGLAHPDKPLPAGEAEPLSAAQDRRVKTDGDLRELLVSRPDGTVDAEIDIGGEGRGWLAPYEVAADTGAPEEVLTFMLENGLRRTAFTAWRNEGDTESVVMINLYQFRNDATAGSVDYLENQQLYSSLGPGGRVPAVSLKGSADGMAYFPEEPFQEAGVPPLYQGMAIARRGDIVMEIYQIESSPLEQKDLKKLAERQLERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N575</accession>
    <name>A0A0F7N575_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Biotin carboxylase</fullName>
            <ecNumber evidence="2">6.3.4.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AA958_10335</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CNQ-509</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="6.3.4.14" evidence="2"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_10335"/>
    <dbReference type="EnsemblBacteria" id="AKH82558">
        <property type="protein sequence ID" value="AKH82558"/>
        <property type="gene ID" value="AA958_10335"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_10335"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2178"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004075">
        <property type="term" value="F:biotin carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001882">
        <property type="entry name" value="Biotin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CbamoylP_synth_lsu-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00188">
        <property type="entry name" value="BIOTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0092">Biotin</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="11">
        <location>
            <begin position="1"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="10">
        <location>
            <begin position="114"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="9">
        <location>
            <begin position="659"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="476"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="530"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="735"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="744"/>
            <end position="759"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AKH82558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="759" mass="78371" checksum="7BE447718C032CC3" modified="2015-07-22" version="1">MFETVLLANRGEIAVRVIRTLRALGIRSAAVFTDADADARHVREADTAVRIESYLSAAELLRAARETGAEAVHPGYGFLAENAEFARACAAAGLVFVGPPADAIELMGDKIRAKETVRAAGVPVVPGSTGSGLSDAELAAAARKIGMPVLLKPSAGGGGKGMRLVRDEDALADGIAGARREARGSFGDDTLLVERWIDRPRHIEIQVLADGHGNVVHLAERECSLQRRHQKIVEEAPSPLLDEATRAAMGAAAVEAARSCGYAGAGTVEFIVPGGGGGPVAYYFMEMNTRLQVEHPVTELVTGLDLVEWQLRVAAGERLTFTSADVPLKGHAVEARIYAETARVAEGGERVDFLPSAGRVRLLREPSGPGVRVDSGLLEGTEVGTAYDPMLAKVVAWGPDRAAALRRLRAALAETVVLGLDTNTGFLRRLLAHPAVASGDLDTGLVDRTGASLAAAPVPPEAYAAAALLAQSALESASRRPTGPDGWTDPFAEPSGWRPGGPPAWTTRWFRAAGQDPVEVRIRGLTPAAEVCTGATPQTPGTPGGPVDTAPRGAPVSAPAGGEAAAAGEGAQPRGGAGAEPSGGSRGRSPRVSGRSGVGEHPLRARLAHADDSSVTFELDGVTHRFSLAASPGGIWLGRDGDVWHLLDHDPVDAALRGGALVAGADALTAPMPGTVTVVKAAVGDRVAAGQSLLVVEAMKMEHVIAAPHAGTVAELDVVVGGTVAMDQVLALVVPDDGQDDGQGDTQGDGRRDEPEDPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5I3</accession>
    <name>A0A0F7N5I3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_07340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015422.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_07340"/>
    <dbReference type="EnsemblBacteria" id="AKH82072">
        <property type="protein sequence ID" value="AKH82072"/>
        <property type="gene ID" value="AA958_07340"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_07340"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1537"/>
    <dbReference type="OrthoDB" id="1379602at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="8"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="279" mass="31923" checksum="52C9FED9E00B42DF" modified="2015-07-22" version="1">MKRLPIVVAIPTKNEAENIATTVRSVIDHFEAVVVVDSDSTDDTRALAADQGAEIVPYTWDGKYPKKKQWCLDHVHPELDWMLFVDGDETPSPELIAELHRIFDPAADGSVKVAPAAFDIPLGYWFAGKRLRHGYTIVKRALMDRTRVRFPELGDLEAPGMGEQEGHYQPLADGPVVRLRATIEHEDLDPVRTWFERHNRYSDWEAWLELHPEVREEIRQAKTRQGQLFHKAPLKPLVSFAYAYVCKRGFLDGRAGLDYALAMSFYRWQIGLKTREKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5L1</accession>
    <name>A0A0F7N5L1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_11170</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_11170"/>
    <dbReference type="EnsemblBacteria" id="AKH82699">
        <property type="protein sequence ID" value="AKH82699"/>
        <property type="gene ID" value="AA958_11170"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_11170"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2354"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="1"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="152"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="282"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="421"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH82699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="443" mass="45408" checksum="FA51B29CDB1C0C78" modified="2015-07-22" version="1">MIGRGSAGTVWLGEGPDGPVAIKLLREDLAEDRELVERFLGERAALMSLDHSRVVGVRDLVVDGRDLALVMDLVRGTDLRTRLERDRRLLPQAAVAIAADIAEALAAAHAVGLVHRDVKPENVLLDSDAPAGAGGAPPALLTDFGVAKLIDAPSRAPQPPPAPRGRGGTAAGTRVPTQRRVIGTPDYVAPEIVEGLPARAAVDIYALATVLYELLAGFTPFGGGHPGAVLRRHVTETVAPLPGIPDELWELLLQCLAKAPASRLRAVELAARLREILPDLDGLPPLDVEESADGADEAGGRSPHTMRLGGDRETAPAGALATAGEPGVTGAGGRPLRGSVPLVRSAAPDSNRDTHTSMRMPSADELAGGARGTARVPRLAGQPRPGSARAARATATRAKRLKLTVAAVVIALAGVGGWLVASGGDDGGGGGSGGGDRSTTSEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-08-12" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5P9</accession>
    <name>A0A0F7N5P9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LytR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_11420</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LytR/CpsA/Psr (LCP) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016075.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH82739">
        <property type="protein sequence ID" value="AKH82739"/>
        <property type="gene ID" value="AA958_11420"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_11420"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2403"/>
    <dbReference type="OrthoDB" id="491753at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027381">
        <property type="entry name" value="LytR/CpsA/Psr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004474">
        <property type="entry name" value="LytR_CpsA_psr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13399">
        <property type="entry name" value="LytR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03816">
        <property type="entry name" value="LytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00350">
        <property type="entry name" value="lytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LytR_cpsA_psr" evidence="3">
        <location>
            <begin position="86"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="LytR_C" evidence="4">
        <location>
            <begin position="362"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="322"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH82739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="476" mass="51049" checksum="D734564E9D9EADEC" modified="2015-07-22" version="1">MKRPRWGLRIATALSLLLLATGGAGYFLLSSIGSGIDRVDAFGGISDRPREGHGLTFLVAGVDRRDSVSEEDRRKYRLGGEPCNCTDALMLVHLSKDRERASVVSIPRDSYVELPPHTNRALGERRTAHAAKVNAAYTHGGPPLTVRAVEKLSGVHIDHYVEIDFAAFMKTVDVVGGVQVCTQRPLRDKYSGLDLPAGTSSLDGGEALAYVRARHLDGASDMGRMKRQQRFLAAVIDKLTGTSGLMNPLRFREVGSTLLGSVRTDAALDTGAVFSLGKALHGFSPGSSEFATVPVADMDYEVPGLGTTVRWDEERARRLFDRLREDRPLKARGGGPDGRKGQGKGQGKGQGRATPVEVPPEQVRVQVANGTGEDGLGGRVDRSLARTGFDTTGAPATAARTDRTVITYDPEWDRSARSLAAALPHAKLVPERGHGALMAVTLGDDHEKVHRVRPADPVLDGADVWSAVTGDEVLCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N615</accession>
    <name>A0A0F7N615_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_19665</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017317.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_19665"/>
    <dbReference type="EnsemblBacteria" id="AKH84025">
        <property type="protein sequence ID" value="AKH84025"/>
        <property type="gene ID" value="AA958_19665"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_19665"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4144"/>
    <dbReference type="OrthoDB" id="602555at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005182">
        <property type="entry name" value="DUF304"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03703">
        <property type="entry name" value="bPH_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="58"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="265"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="405"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="429"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="bPH_2" evidence="3">
        <location>
            <begin position="113"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="bPH_2" evidence="3">
        <location>
            <begin position="463"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH84025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="559" mass="58732" checksum="F001F426B2873159" modified="2015-07-22" version="1">MTDAATDTGPGVPGERPATPAGVPDPARAAPRTPAAAAGSPAPPDAAPDWRRLDRRSLLVTAQLLLGAAFGAGVPVGAGLAAHLDFRAAVAWVLAGCVVLLGGGLAVDVLRLRHTRYRVGADRVELRTGVLFTSRRSLPRDRIRTVDLTAHPLFRLLGLVKVRIGTGDQAAAGESALQLTPVRRAEGESLRRALLRRDTTAAPAGDDPRLAALSPGWIRYAPLSFLTPLLALTGWGAVMQVSQWFGAEETVVDWVRDTFSPLPALWTVLALGSIALVTGFVGSLGVWTEMWWSYRLEREPDGTLRVRRGLLTTRSISLEEARLRGVDVVEPLGVRLSGAARVEAIATGLSRKDGEDEDLSALLPAAPRAVVDEVTARVLRAPVALTRPELAPHPRAALARRLRRSLGAALVPVVMLVALGAALSVRGPVYAGAVAAAVLLPAAALLARDAYRSLGHGLAGPYLVVRSGTLRRSTVALRRDGVVGWTVRQSLFQRRAGLVTLRATTAAGAQAYAAYDVGEAQGLRFAAEAVPGLLTPFLVTGAAADGRAPAPVPADEDAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6D3</accession>
    <name>A0A0F7N6D3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AA958_20555</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH84180">
        <property type="protein sequence ID" value="AKH84180"/>
        <property type="gene ID" value="AA958_20555"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_20555"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4336"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="401"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="15"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="300"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="428"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="543"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="568"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="432"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AKH84180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="593" mass="59944" checksum="9AE0380EC6A5F4A9" modified="2015-07-22" version="1">MQPVQSGDPEAVGPYRVLGRLGSGGMGRVFLGRSPGGATVAVKVVHPHFAHDDEFRARFRREVEAARRVGGAWTAPVLDAGPDDDVPWVATGYVAGPSLGDAVAEHGPLPEETLRPMGAGLAEALAAVHGLGLVHRDVKPSNVLLTLDGPRLIDFGIARATDGTASLTASGASVGSPGYMSPEQILGRPVTGAGDVFSLGAVLVFAATGRSPFPGDSAPTLLYLVVHEEPQLHGLSGELGELALACLSKDPAGRPEPAELVDRLTAGGEAAHLVRPGWLPPPVTEQISRRAVELLAMEAQPAAAPERRDDGLPSGPVPLQQAEYGPGAFGPPPVLDGTAAGATAGAGAPGAPQADGAAAWATPPDGAGAGAAGAALGAAAVTAPERRAEVGLRSRRFSCTLVLSVAGALAALMLGLFFVPGLLDGGADRPQAQNPTGGNSAGNGNDRGNEDGAGGSGGAATDSPSPEPTKAVDGVPERFLGTWNGEVLQDDGVPNGRVSVEIEEGGKGEYVAYFDYSLYDVAHCYSRAKLTAATGGSLVLREEDDPARKNSEGVCAPGTSEVTLTHKGGATVEYRSDAEASGNPRATLRKGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6W4</accession>
    <name>A0A0F7N6W4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">APH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_13730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_13730"/>
    <dbReference type="EnsemblBacteria" id="AKH83118">
        <property type="protein sequence ID" value="AKH83118"/>
        <property type="gene ID" value="AA958_13730"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_13730"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2890"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="26"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="369" mass="39803" checksum="5E80A5A79C10F693" modified="2015-07-22" version="1">MPASQASPFQTIFAVAEQVVGPLPGYHHETYAVRLGAASGLFGQSAGWVKLRDPRPGLLWFDRRCFGSEDELLATLAGRVSHIPAVGHIDSLTVQGFIEGCTLAEVAPPGEEVPAAFVGQIIRLFRELLAVDPCDPALLALHAPLPAERGSAEFARDLVRFTFTDVVEHSLPHFDALFHSLSIHPGSAPATPSSLEARLRGMTPRPFGLLHGDVHRANLIVDEHDALWAIDWELALIGDPLYDLATHLHLMRYPARQEGEVIARWADVAEESRPGAAAGIEADLPRYLAFKRIQSVYTDVIRQAYSTERGETSTAEAAKVINAALDRAADSLLLPTVAGAGEIEHQLVRWLATPRPRGAANTGGTPSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N736</accession>
    <name>A0A0F7N736_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_18560</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017173.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH83876">
        <property type="protein sequence ID" value="AKH83876"/>
        <property type="gene ID" value="AA958_18560"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_18560"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3895"/>
    <dbReference type="OrthoDB" id="149255at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004869">
        <property type="entry name" value="MMPL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03176">
        <property type="entry name" value="MMPL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="268"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="297"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="362"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="520"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="548"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="577"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="623"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="658"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="7">
        <location>
            <begin position="197"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH83876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="706" mass="74350" checksum="E9B611C3BF86D5E8" modified="2015-07-22" version="1">MFVRVGGFAYRRKWIAVILWVAVLFGVYGVATAVGDTYKDDMSLPGTEAQAAADLLAEHGAERAGDTIDIVLHDEGGLAQVQQRVDPMLAEVAELPNVGGVQSVYENPNAISEDGTIGYATVQLEVPSVDMPVEDTERILDAAQEIEGEGLQVELGGEAVRALAEGETGVGEMVGLVAALVILVVMFGTFIAAGLPIVIALFAVGSTVGVIILASHLFTIASWTPPVMFLVGLGVGIDYALLIFARYRTELVKGVEPERATITAMDSAGRSVFFAGCTVLLALLGLTALGLGSIQGMALSVALTVLMTMIASLTLLPALLSIFGKRFARQFLARAEKRKAKGKAQDGERWRKLATAVQKRPLAALLTAAVLLGALAFPALSIRLGFNDAGNDPSDSTSRQAYDLLSDGFGPGFNGPLLVVTEGGDGTAEEAATAAAQTLGETEGVAATAPPIPTPDGEAAMVLVYPVTSPQDEKTTELVGTLRDDVLPGLTADNGAEYFVGGGTAASEDYAGKLADRMPLFMIIVVGLAIVLLMAVFRSILIPLKAAFLNLLSIGAALGVMKLVFQDGRFGFEGGPIEAYVPVMIFAIVFGLSMDYEIFLISRMHEEWVNSKDGDPSRAVREGLAHTGSVITAAGSIMIVIFAAFILSPTRMLQQSGLAFAVAIFVDAVIIRCMIVPAAMELMGKRAWWLPAPLAKILPKVELEKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7B2</accession>
    <name>A0A0F7N7B2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cobalamin-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_22305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017736.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_22305"/>
    <dbReference type="EnsemblBacteria" id="AKH84475">
        <property type="protein sequence ID" value="AKH84475"/>
        <property type="gene ID" value="AA958_22305"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_22305"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4697"/>
    <dbReference type="OrthoDB" id="927390at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003759">
        <property type="entry name" value="Cbl-bd_cap"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036594">
        <property type="entry name" value="Meth_synthase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02607">
        <property type="entry name" value="B12-binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="SSF52242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B12-binding" evidence="1">
        <location>
            <begin position="102"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="361" mass="37896" checksum="1D613601F9E59F57" modified="2015-07-22" version="1">MSETRIPEAARARFDACLAAADEDAAVELAVGLVTGGVSAEDVLLRLVAPAQVRIGARWESGEWTVSQEHAATHVSRKTVDAVAAAAAARGTIRLPGGAGSRGHVLVACSDGEWHVLPAQILTEVLRLHGFDVRSLGGSVSPQGILSDVHQHGPDVVALSCTLPWNLPLAHRQIEICRWAGVPVVTGGAGFGPGGTWAYALGADLYAADARDAADALMRHWPPVLRGESSVEADAVEAYAMLVRQRPGLLEHMASALRDMHPGPGTGSVSGMEHEEGAGVLGRLLDSLAAAVYVDDERVFTQHLAFVRTYLSARSADSHFLIVMADALADRLKGSPQALDKLSAGRRFLARGEEDDSGGPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7G6</accession>
    <name>A0A0F7N7G6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Enolase</fullName>
            <ecNumber evidence="8">4.2.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">2-phospho-D-glycerate hydro-lyase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">2-phosphoglycerate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 13" type="primary">eno</name>
        <name evidence="13" type="ORF">AA958_11730</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(2R)-2-phosphoglycerate = H2O + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:10164"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="4.2.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="8">The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Cell surface</location>
        </subcellularLocation>
        <text evidence="8">Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the enolase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.11" evidence="8"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016128.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_11730"/>
    <dbReference type="EnsemblBacteria" id="AKH82792">
        <property type="protein sequence ID" value="AKH82792"/>
        <property type="gene ID" value="AA958_11730"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_11730"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2466"/>
    <dbReference type="OrthoDB" id="533698at2"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00187"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000015">
        <property type="term" value="C:phosphopyruvate hydratase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004634">
        <property type="term" value="F:phosphopyruvate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4 8" id="KW-0964">Secreted</keyword>
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        <location>
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            <end position="134"/>
        </location>
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        </location>
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        </location>
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        </location>
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        </location>
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        </location>
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        </location>
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        </location>
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        </location>
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        </location>
        <ligand>
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        </source>
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        <source>
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</entry>
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            <authorList>
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH82812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="253" mass="27774" checksum="9DA8BC0831268552" modified="2015-07-22" version="1">MEPIRVTSLAERPELRARLWEMADSWPEFMTHDHVANALHERIAEVFPEHVHVATDESGAVVARAFAVPFALRGPGRDGALPGRGWDEVLVWAFQDRRDGVEPDTVSAIEVAVDAGRQGGGLSAVMLGAMRTAAADRGFAEVVAPVRPSAKHLEPHTPISAYATRVRDDGLPHDPWLRVHIRAGATLAAPDPVAPASMVIAAPLPQWREWTGLPFDKEGWTTVPGALTPVRCEPAHNWAVYVEPNIWLRHHLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7Q1</accession>
    <name>A0A0F7N7Q1_9ACTN</name>
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        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
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    </gene>
    <organism evidence="5 6">
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        <lineage>
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        </lineage>
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    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="20"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH83453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="364" mass="38790" checksum="CF62A8626EB49517" modified="2015-07-22" version="1">MTGSIQPQVSRPPSRKLARAGIRDVAAAAGVSITTVSDALNGKGRLPEATRRHVREVADRLGYRPSAAARALRTGKSGLIGLTVTTYGEEPFTFTEFAYFAEMARAATSAALARGYALVILPATSRHDVWSNVALDGTVVIDPAEGDPVVSEIVRQGIPVVSDGRPGGSLPVTAWVDNDHQAAVLDLLDHLADAGARRIGLLTGTSTDTYTRLSTTAYLTWCERVGQDPVYESYPAHDPRAGAVAADRLLARPDRPDAVYGLFDPNGTDLLAATRRYGLRVPDDLMLVCCSESPGYASTDPPITTLSLKPRRIGTAVVQLLIDAIEGVDAGRPIEQVIPTDLIVRASSQRRPPRTVVSAPRRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7R2</accession>
    <name>A0A0F7N7R2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cupin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_15830</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016746.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_15830"/>
    <dbReference type="EnsemblBacteria" id="AKH83434">
        <property type="protein sequence ID" value="AKH83434"/>
        <property type="gene ID" value="AA958_15830"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_15830"/>
    <dbReference type="OrthoDB" id="1928636at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF51182"/>
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            <end position="103"/>
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            <begin position="9"/>
            <end position="30"/>
        </location>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH83434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="125" mass="12867" checksum="A2F43C77E4F787D2" modified="2015-07-22" version="1">MKVITPAPDRTVTTPNASMESLATPSRGSTALSTWRVRMDAGRSGPVHVIDREQVWMVISGSLTVTCDGRTETAAAGQAVLLPSGVPRRLGAAEGTGAVEALVAMEAGGSAVTEDGARHALPWAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7T2</accession>
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            <authorList>
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">CNQ-509</strain>
        </source>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="579" mass="61012" checksum="F2BF0EF5FFEFBA43" modified="2015-07-22" version="1">MSQPPPPPGQPPSGGFGPPPAEDPQQPGYGYPQAPPPPAPGGGFGAPQEPQQPAQQPQYGYPPAQPQPSQVQPPPPPQAPAAPPQEHYSFAQPAPQHSGGYPQAQVPGMPAKQDAQKLVPVWAVIAAVVAILVVASGTGFFLTRDDGGTQAGGGGGGGGAKKAVSDSKPASADGELLFGVPYPQAEEGATWPAEGQWATEKIYAKGELNAVKGYDTTTGKEVWELPTDGLVCGASRAVTDDGKAAMLVQDGKVSDPDDTYAPCSEVVVFDVNSGEELWKQHVATADESLKFEYVTIADGTVIASGLSGSAAFPLAGGDPVWQTKPTTECKDHDYASDGTNLLGLVFCGSLNEDMKVQKVDPATGGIYWSYDVPDGVQSVQVLSVEPPVITIGAGKTTETDIFALDEGELRSKISLGTETAGPRYKPGCDYSDGAESCTTVAVDGDTMYLPSREHQGKSDYGDTNEIVAFDLDTGKPTKKYDAGEKRTMVPLRMDSGKIIAYRKGTYDSGGEIVAIDPRSAKEETWLELPNDTAEAEATLTYSDSVPYIFEHGRFYLAQDIISDRDDVEYFALAFGSKKQ</sequence>
</entry>
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    <accession>A0A0F7N7V1</accession>
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        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
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    <dbReference type="Proteomes" id="UP000034283">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <end position="158"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AKH82877.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N842</accession>
    <name>A0A0F7N842_9ACTN</name>
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        </recommendedName>
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    </gene>
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        </lineage>
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    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
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        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <dbReference type="OrthoDB" id="1891092at2"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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        </location>
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        </location>
    </feature>
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    </feature>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AKH83608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="262" mass="27472" checksum="67B9065C292F523D" modified="2015-07-22" version="1">MSAPGTYVLRDSATMLRRNLRHMARYPSMTLMLVGQPLLFLLLFTYVFGGTMGAGLPGGDRGSYPTYIAPGILTMTVASVSIGTAVLVANDMTDGIIDRFRTMPIAKSSVLTGHVLAAMIQTALALAAVGAVAFALGLRTGASAADWVCLAGLLGLLSYALTWFTVALGLASPDPETASNLPMVFVLLPFVGSGFVPVDTMPAGLRWFAAHQPFTPVMDLIRGLLDGAPDGVDAAWAAGWCAALGAAGYLWSRRLYRTRAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N874</accession>
    <name>A0A0F7N874_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Endoribonuclease L-PSP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_12885</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016306.1">
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_12885"/>
    <dbReference type="EnsemblBacteria" id="AKH82972">
        <property type="protein sequence ID" value="AKH82972"/>
        <property type="gene ID" value="AA958_12885"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_12885"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2711"/>
    <dbReference type="OrthoDB" id="1850770at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="PTHR11803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="SSF55298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH82972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="131" mass="13866" checksum="52CCCA6F4200358C" modified="2015-07-22" version="1">MERTAINPVTWSTEMGFNQGELVSGHTRTLFVSGQTAMSPEGRPQHADDMAAQLALSLDNLEAVLAGADMSLENLVRLNVYTTDVDALFPHYGELAARLAAAKAAPATTMLGVTRLAIPTLLVELEATAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8B5</accession>
    <name>A0A0F7N8B5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_17270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016973.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH83669">
        <property type="protein sequence ID" value="AKH83669"/>
        <property type="gene ID" value="AA958_17270"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_17270"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3631"/>
    <dbReference type="OrthoDB" id="1721089at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519168" evidence="1">
        <location>
            <begin position="28"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="247" mass="25816" checksum="DE6B56EF3B25CD19" modified="2015-07-22" version="1">MKYVIRGRRVAVAAAGTAALLAFTACGSDDEGGGGASGGPAQTDAVEAMRAATSVHAVGEMIVVADPARIDVQVDDKGNCVGSATTDDGAVEFVMQGDKAWMKPDAAYLESEYMFDAAVIEQVQGSYLEEPKSDVQSAITDLCKIDTYAEQTDSVVSFSPGMTQKEETKHKGVAVVPYVNEDPETSDGASMKIAAEGKPYPVTITDPEGAEVDLAFSAFGEPVKPKAPAADSVLTEDQVSDIEFEAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8B7</accession>
    <name>A0A0F7N8B7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AA958_17500</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNQ-509</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="6">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017007.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_17500"/>
    <dbReference type="EnsemblBacteria" id="AKH83703">
        <property type="protein sequence ID" value="AKH83703"/>
        <property type="gene ID" value="AA958_17500"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_17500"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3683"/>
    <dbReference type="OrthoDB" id="267896at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016668">
        <property type="term" value="F:oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 8" id="KW-0274">FAD</keyword>
    <keyword evidence="2 8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 8" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="10">
        <location>
            <begin position="4"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_dim" evidence="9">
        <location>
            <begin position="333"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="138"/>
            <end position="140"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="175"/>
            <end position="182"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="7">
        <location>
            <begin position="41"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AKH83703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="469" mass="48804" checksum="5DA71F108BDEDC5C" modified="2015-07-22" version="1">MSPYDMVVIGGGSAGLTAARTAGRLGARTLLVESGRLGGDCLWTGCVPSKALLHVAAETAAARRAGAYGLAAASGPVDLASAMRHVKGAIAAIEPHDSAESLRPLGVETAYGRAAFSGPRTLTVAEREISFRYAVIATGSSPTLVPVPGLAEADPLTSDSLWDLDRLPERLVVLGGGPIGCELGQAFARLGAQVTLVEAMERLLPREEPDASQAVRRALEADGVTVLAGYRAERVTGSAMHGPGGPLAYDTLLAVTGRRADTAGLGLAEAGVQLTDRGDVRVNDRLRTANPRIYAAGDVTGRSAFTHLGGVQGGAAAAEALLGVRRRIDYGAVPRVTFTDPEVARVGRTAAEARAEHGDTVRVHTLPHDRVDRAVAEGRTDGFTTLVLGPRARIIGATVVAPRAGETIAHLAAAVRLGWTAPQYARTVHPYPTYADGPWHAALADVYDRLARAGRITGAALALRRKLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8G8</accession>
    <name>A0A0F7N8G8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_21410</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017594.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_21410"/>
    <dbReference type="EnsemblBacteria" id="AKH84331">
        <property type="protein sequence ID" value="AKH84331"/>
        <property type="gene ID" value="AA958_21410"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_21410"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4507"/>
    <dbReference type="OrthoDB" id="1196738at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="24"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="130"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="403"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH84331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="433" mass="45730" checksum="FCBFD103D28B3772" modified="2015-07-22" version="1">MADPLATPVPVSGPGGWARAGRRAGIAGVAIGVLAAGAAAGVAVERLAMGRDVRRRARQALDAAGPYGTFRGTSGTAVADDGTELYYEIEEADDFPPVLPDGTPPDPLTAAPRRRRRRFAGRRDPAPLTVVFCHGYCLTQDSWHFQRAALRGRVRTVYWDQRSHGRSARGISQLAGDEPVTIDQLGRDLKAVVDAAAPEGPLLLVGHSMGGMTIMAFADQFPDAVRDRVAGAAFLGTSAGDLGRVTFGLPAAGAWAVRHFVPGVLKALGSRAELAERGRQATADLFAGIIKHYSFGTEGVDPGVARFAERLLESTPIDVVAEFYPAFAAHEKDEALALLRDLPGLVLVGDRDMVTPPEHSERIAARLPGATFEVIEDAGHLAMLERPERVNDALAALLARAGERLPTGPGPEPGVGPGAGPVRRPRGTSRRTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8I3</accession>
    <name>A0A0F7N8I3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH marR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_17735</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017046.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_17735"/>
    <dbReference type="EnsemblBacteria" id="AKH83744">
        <property type="protein sequence ID" value="AKH83744"/>
        <property type="gene ID" value="AA958_17735"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_17735"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3734"/>
    <dbReference type="OrthoDB" id="1646730at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
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    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
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        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="2">
        <location>
            <begin position="47"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH83744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="186" mass="21075" checksum="722A6B3F3F6C67D4" modified="2015-07-22" version="1">MADQQRDERGGREERGDGAERRAGAGRDTEAVARYVERVAGELTGMGMQRMASRVFACLLADDAGALTAAEVSERLHVSPAAVSGAVRYLGLVGFISREREPGSRRERYRIESDRWYQIFAQREQIIRRFEQTLDSGVGILGADTPAGQRIEETTEFFAFLREENGRLEQRWWDYVKRRQEATAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8Q8</accession>
    <name>A0A0F7N8Q8_9ACTN</name>
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        <submittedName>
            <fullName evidence="5">LacI family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_18630</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83883.1"/>
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        <property type="gene ID" value="AA958_18630"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
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        <property type="match status" value="1"/>
    </dbReference>
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        <location>
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            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH83883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="344" mass="36342" checksum="B8C4F55F30C47FFD" modified="2015-07-22" version="1">MSQQRPGDAGAPTMRDVAHRAGVSTMTVSRVLKDDARVSEETRRRVLAAVDALGYRLNATARSLRLGGSGMIGLIVTNLANPFYSRLALGVQEVASEHGLSMLLGNTGEHLDRERGLVEDLASRQVAGMIVVPAGGSHSHLTPAALRDMPVVLVSRPPSGLEADCVLVDDFGGARDATARLLAAGHRRIGFLGNPPAIHTGAERFRGYRAAHEAAGLEPDDGLVRRGLTDVATAERAARELLAPGGAPGSGTAPTALFCTNNRLTQGAIRAVRALELPVVLAGFDDFDLADVLGMPLTIVSYDADEMGRQAARLLIDRINGGPTASWPPRRTVLPTHVIRYGPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8U3</accession>
    <name>A0A0F7N8U3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sugar ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_25145</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018201.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_25145"/>
    <dbReference type="EnsemblBacteria" id="AKH84950">
        <property type="protein sequence ID" value="AKH84950"/>
        <property type="gene ID" value="AA958_25145"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_25145"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5299"/>
    <dbReference type="OrthoDB" id="447734at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
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        <location>
            <begin position="20"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="421"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="426"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH84950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="446" mass="48837" checksum="3723AB3071338621" modified="2015-07-22" version="1">MLATALTAVLAATALSACGDSGSDPDTVRVQFKKSTDAKNKIFDREIEAVKKEFEEKFPGKKVELIPVQVPDEQYYTKVQQMLRSPKTAPDLVYEDTFLINSDIAAGLLTPLDDYLKDWKDWGQYIDTAKTAAQGQDGKTYGVPDGTDTRGLWYNKELFAEAGLPTDWQPKTWDDVLDAARTIKRELPGVIPLNVYTGKPAGEASSMQGFEMLLYGTGEDPLYDPGSKKWVAGSQGFTDALDFVHTVYNDGLGPDPQDALDPNVGTKVGTEWLPEGKLAIDLDGSWMSNNWLETGPKPWPEWTEVLGQAAMPTQNGQAPGRVSMSGGWAWSIPAKANNPDLAFEFMKVAQSRKNNTRLTIANGQIAVREDVAADPEYQAYVPGVEFFTGLVEDTHYRPALPVYPQVSTAIQEAMEQVTTGDASAEEAAKGYDEQLDSITDGEVVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8U8</accession>
    <name>A0A0F7N8U8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RNA polymerase sigma 70</fullName>
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    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_14020</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
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        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016495.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH83167">
        <property type="protein sequence ID" value="AKH83167"/>
        <property type="gene ID" value="AA958_14020"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_14020"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2951"/>
    <dbReference type="OrthoDB" id="1914729at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="5">
        <location>
            <begin position="19"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH83167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="314" mass="34236" checksum="1C032F905CD39FE8" modified="2015-07-22" version="1">MDEQKCPEGHPAERLAERFEAERSRLRAVAYRMLGSAAEADDAVQETWLRLSRSDADAIEDLAAWLVTVVWRICLNMLRSRRFRREEPLEYAHEGAAAPETWDPASERAPGPRDPEEEALLADSVGVALLVVLDTLAPAERLAFVLHDMFAVPFDEIGPMLERTPAAARQLASRARRRVRGRAAPPAAPGEDLRRRRRVVDAFLAATRGGDFEALVSLLHPDVVLRADRAAIPTPEPVEVRGATPVAQGAMAAAGRAQFTGPALIDGGVGLVMAPLGRMRLLLRFTVADGLITEIDVIADADRLRDVELGVLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8Y2</accession>
    <name>A0A0F7N8Y2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Putative 4-hydroxy-4-methyl-2-oxoglutarate aldolase</fullName>
            <ecNumber evidence="5">4.1.1.112</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Oxaloacetate decarboxylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Regulator of ribonuclease activity homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">RraA-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AA958_14260</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2-oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H(+) + oxaloacetate = CO2 + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:15641"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="EC" id="4.1.1.112"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class II aldolase/RraA-like family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.112" evidence="5"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_037721307.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_14260"/>
    <dbReference type="EnsemblBacteria" id="AKH83202">
        <property type="protein sequence ID" value="AKH83202"/>
        <property type="gene ID" value="AA958_14260"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_14260"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3001"/>
    <dbReference type="OrthoDB" id="1614890at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008948">
        <property type="term" value="F:oxaloacetate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16841">
        <property type="entry name" value="RraA_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005493">
        <property type="entry name" value="RraA/RraA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036704">
        <property type="entry name" value="RraA/RraA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03737">
        <property type="entry name" value="RraA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89562">
        <property type="entry name" value="SSF89562"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AKH83202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="217" mass="22569" checksum="32CD9EE881E83290" modified="2015-07-22" version="1">MTTTIPPETIAAFHGIATASVADAVEQKGVRGYLTGGIKAMLPGKLVGPAVTVQEVPSPVSEPPTHALRAIDESEPGSVICIAAGGADVAVWGGLMAAGAVTNQIAGAVLDAGVRDVEEIRRDYPELPIYARGAVPATTVGRYRTVSLNEPVEVGGVPVRPGDLIVADSDGVVCVPQELVAEVLALATDIEEREREQTRLIRESGSLQGGLEKYQRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8Z4</accession>
    <name>A0A0F7N8Z4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_25475</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018261.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_25475"/>
    <dbReference type="EnsemblBacteria" id="AKH85010">
        <property type="protein sequence ID" value="AKH85010"/>
        <property type="gene ID" value="AA958_25475"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_25475"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5369"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01948">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00563">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00052">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141868">
        <property type="entry name" value="SSF141868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50883">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="82"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="123"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="203"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="4">
        <location>
            <begin position="281"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="EAL" evidence="3">
        <location>
            <begin position="422"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="675"/>
            <end position="715"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH85010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="715" mass="76279" checksum="A5618F5837773F82" modified="2015-07-22" version="1">MRPTESTEPAPVLRRLVLPALPWLAQAAGGLVFAIGVLYGLREGHALFPRGTAGWGLAVLTVVLIAHLVAPGRDRWSGGNGSAAALTLAVLLLYGWIPAVAVSLLVILAVALVRRPYRRQAPLHGAVEILGISTAAVVLWTCGEHPTVEEPWEPGSWDLYALPELIAAALAYVLVTRVLTWYADPGHREGPGLLARAALTRQGLSGAALLGIAPLVIVVAVNTPVLLPLFAVPLIALDSSLWMARARAEEQLRDPLTGLPNRQWLLERTWHALAEAESTGRRAALILIDLDRFRAVNDTLGHRAGDRLLLQLAGRLRLALPRGAEAARLGGDEFAVLIPLTDSATSAQRVARTLVAALGSPLDLDGMSLVLEASAGVAVYPEHATETEGLLQRADVAMYQAKRDRSGVEVYEARRDGNTPDRLGLLGDLRRALQAREVALHYQPKVGFDGRVVGLEALVRWAHPERGHVNPEEFIAIAETSGLMPVLTEYVLETALAQVADWRAAGLQVPVAVNVSPRDVHTPGFAGAVAARLARHGVPPGALQLEITEHVLLEDPQRAADTLAGLTGHGVKMSLDDFGTGYSSLVHLRRLPVSELKIDRSFVARLAVDPEDLEIVRCTVDLAHSLGLRVVAEGVEDDETWEHLRDLGCDAVQGWLVAAAMPPAETTAWLRARGPGPGARALPAAASAARAADEPATAVAVPQPDEAEEPVKPVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N980</accession>
    <name>A0A0F7N980_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Copper-sensing transcriptional repressor CsoR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_22920</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CsoR family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017838.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_22920"/>
    <dbReference type="EnsemblBacteria" id="AKH84581">
        <property type="protein sequence ID" value="AKH84581"/>
        <property type="gene ID" value="AA958_22920"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_22920"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4827"/>
    <dbReference type="OrthoDB" id="1868412at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003735">
        <property type="entry name" value="Metal_Tscrpt_repr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038390">
        <property type="entry name" value="Metal_Tscrpt_repr_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33677">
        <property type="entry name" value="PTHR33677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02583">
        <property type="entry name" value="Trns_repr_metal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0186">Copper</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH84581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="95" mass="10389" checksum="18FC7495F4CD80AD" modified="2015-07-22" version="1">MELELEGADLKAVLNRLRRAQGQISGVIRMIEEGRDCEDVVTQLAAASRALDRAGFAIIATGLQQCVTDMESGRKNGEDPEAMRARLEKLFLSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9G0</accession>
    <name>A0A0F7N9G0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribonuclease J</fullName>
            <shortName evidence="9">RNase J</shortName>
            <ecNumber evidence="9">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">rnj</name>
        <name evidence="12" type="ORF">AA958_26430</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer, may be a subunit of the RNA degradosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Bacterial RNase J subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="9"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018420.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_26430"/>
    <dbReference type="EnsemblBacteria" id="AKH85180">
        <property type="protein sequence ID" value="AKH85180"/>
        <property type="gene ID" value="AA958_26430"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_26430"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5565"/>
    <dbReference type="OrthoDB" id="580619at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' exoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01491">
        <property type="entry name" value="RNase_J_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004613">
        <property type="entry name" value="RNase_J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042173">
        <property type="entry name" value="RNase_J_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030854">
        <property type="entry name" value="RNase_J_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041636">
        <property type="entry name" value="RNase_J_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17770">
        <property type="entry name" value="RNase_J_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004803">
        <property type="entry name" value="RnjA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00649">
        <property type="entry name" value="MG423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7 9" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="9" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Lactamase_B" evidence="11">
        <location>
            <begin position="31"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9 10">
        <location>
            <begin position="373"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR004803-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AKH85180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="561" mass="60431" checksum="7EF927C462AE9ED8" modified="2015-07-22" version="1">MSHPHPELGPPPALAEGALRVTPLGGLGEIGRNMTVFEYGGRLLIVDCGVLFPEEEQPGVDLILPDFSTIRDRLDDIEGIVLTHGHEDHIGAVPYLLREKADIPLIGSKLTLALIEAKLQEHRIRPYTLQVAEGGRERIGPFDCEFVSVNHSIPDSLAVAVRTPAGVVVHTGDFKMDQLPLDGRLTDLPAFARLGEEGIDLLLVDSTNAEVPGFVAPEKDISGVLRGVFAAAQRRIIVASFASHVHRIQQVLDAAHGYGRKVAFVGRSMVRNMGIARDLGYLRVPAGLVVDVKTLDDLPDREVVLVCTGSQGEPMAALSRMANRDHQIRIVAGDTVILASSLIPGNENAVYRVINGLTRWGANVVHKGNAKVHVSGHASAGELLYFYNICKPRNVMPVHGEWRHLRANAELAAATGVRADRIVIAEDGVAVDLVDGVAKISGKVQAGYVYVDGLSVGDVTESSLKDRRILGEEGIISVFVVVDSTTGKIVGGPHVQSRGSGIEDGAFRDVIPKLEEALAKSASDGVAETHQLQQLVRRTVGKWVSDTFRRRPMILPVVVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9J7</accession>
    <name>A0A0F7N9J7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zf-CGNR multi-domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_20670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017489.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH84203">
        <property type="protein sequence ID" value="AKH84203"/>
        <property type="gene ID" value="AA958_20670"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_20670"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4360"/>
    <dbReference type="OrthoDB" id="1478254at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010852">
        <property type="entry name" value="ABATE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023286">
        <property type="entry name" value="ABATE_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021005">
        <property type="entry name" value="Znf_CGNR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35525">
        <property type="entry name" value="PTHR35525"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07336">
        <property type="entry name" value="ABATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11706">
        <property type="entry name" value="zf-CGNR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160904">
        <property type="entry name" value="SSF160904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-CGNR" evidence="1">
        <location>
            <begin position="157"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="205" mass="22304" checksum="FFE8209BCFD7C668" modified="2015-07-22" version="1">MVDEASARAPGVEMRPPDGQVFRFDPGALSLELLTTGGPGPFARYEVLRTPADVAAWAAASRLRPVPELAVTDDDVPAVRHLRDALFRLTQARARAEPLPAADLAVLNAAAAEPPLAPRLTPDGTPSWAPGPATTARLLATVARDAVDLFSGPYGYRIRECAGERCYLLFADTSRPGRRRWCSMERCGNRHKVRTLRARREADHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9Q4</accession>
    <name>A0A0F7N9Q4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HxlR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_24060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018028.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH84776">
        <property type="protein sequence ID" value="AKH84776"/>
        <property type="gene ID" value="AA958_24060"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_24060"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5071"/>
    <dbReference type="OrthoDB" id="2057904at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="1">
        <location>
            <begin position="24"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="140" mass="15607" checksum="642F898DCD8C26D1" modified="2015-07-22" version="1">MATMTAAQRREQERFAYDAFMRDCPTNQLLGRLSDKWVGLVVAALSGGPRRYSDLRRKIAGVSPKMLTQTLRTLERDGILTRAVTPSVPVRVDYELTPLGRSLAGLLTAVKDWAEEHIEEVHAARERYEKQEPGAAAPEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9S8</accession>
    <name>A0A0F7N9S8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_20700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017495.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_20700"/>
    <dbReference type="EnsemblBacteria" id="AKH84209">
        <property type="protein sequence ID" value="AKH84209"/>
        <property type="gene ID" value="AA958_20700"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_20700"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4366"/>
    <dbReference type="OrthoDB" id="2057904at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="1">
        <location>
            <begin position="22"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="131" mass="14503" checksum="7F216787398B294A" modified="2015-07-22" version="1">MQAEGEATLRLRDFPDVITADCPARNIMEHVVSRWGVLVLLALLEGTIRFSALRRRIGGVSEKMLAQTLQTLERDGLVLREAKPVIPPHVEYSLTPLGEQAALRVRPLAIWAYDSVPAVTAAREGYDEARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NA27</accession>
    <name>A0A0F7NA27_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_24790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH84886">
        <property type="protein sequence ID" value="AKH84886"/>
        <property type="gene ID" value="AA958_24790"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_24790"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="101" mass="10868" checksum="EC5092A22D893145" modified="2015-07-22" version="1">MPRSPSPCRSTRTGRRSGWGWPDRGAPRPASRPAYPRTARAHRRTAPAAARPAWADVRTAGAGGARRTGSSAARRGRARAAHRAPPVRPMSQGNPPSISWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NA32</accession>
    <name>A0A0F7NA32_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptide chain release factor 1</fullName>
            <shortName evidence="5">RF-1</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">prfA</name>
        <name evidence="8" type="ORF">AA958_24815</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 5">Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="5">Methylated by PrmC. Methylation increases the termination efficiency of RF1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018143.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_24815"/>
    <dbReference type="EnsemblBacteria" id="AKH84891">
        <property type="protein sequence ID" value="AKH84891"/>
        <property type="gene ID" value="AA958_24815"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_24815"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5232"/>
    <dbReference type="OrthoDB" id="928964at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016149">
        <property type="term" value="F:translation release factor activity, codon specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="entry name" value="Rel_fac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PCRF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004373">
        <property type="entry name" value="RF-1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03462">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00937">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00019">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RF_PROK_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0488">Methylation</keyword>
    <keyword evidence="4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RF_PROK_I" evidence="7">
        <location>
            <begin position="233"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="262"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="modified residue" description="N5-methylglutamine" evidence="5">
        <location>
            <position position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH84891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="362" mass="39903" checksum="AAA31CA0E05184E4" modified="2015-07-22" version="1">MFEVVKDLIGEHATLERQLADPGVHADQRRATRLNKRYAELTPIIAAYRAWERAGEDAAAARELAAEDPDFAAEAKSLEREREELTERLRLLLVPRDPSDDKNVILEVKAGEGGEESALFAGDLLRMYLRYAERQGWKTELLDANESDLGGYKDVSVSVKLKGGAGQRAAEPGQGVWARLKYEGGVHRVQRVPATESQGRIHTSAAGVLVLPEAEDVDEVEIGPNDLRIDVYRSSGPGGQSVNTTDSAVRITHLPTGIVVSCQNEKSQLQNREQAMRILRARLLAEAQEEAEKEAADARRSQVRTVDRSERIRTYNFPENRISDHRVGFKAYNLDQVLDGELDAVIQACVDADAAAKLADAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAB0</accession>
    <name>A0A0F7NAB0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_22095</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017700.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH84438">
        <property type="protein sequence ID" value="AKH84438"/>
        <property type="gene ID" value="AA958_22095"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_22095"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4654"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519241" evidence="2">
        <location>
            <begin position="27"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH84438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="86" mass="8028" checksum="7DD8E3383DC6F85C" modified="2015-07-22" version="1">MKTRKIVGTALLGAAFAAAAAGTASAAPVPGLPAPVGQVTSPLESVTGSQAGSENGTPNGAADAQPPALGQLGVLTSALPLGSLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAJ0</accession>
    <name>A0A0F7NAJ0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glyceraldehyde-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="9">1.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AA958_22295</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.-" evidence="9"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017735.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_22295"/>
    <dbReference type="EnsemblBacteria" id="AKH84474">
        <property type="protein sequence ID" value="AKH84474"/>
        <property type="gene ID" value="AA958_22295"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_22295"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4695"/>
    <dbReference type="OrthoDB" id="944149at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004365">
        <property type="term" value="F:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020831">
        <property type="entry name" value="GlycerAld/Erythrose_P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020830">
        <property type="entry name" value="GlycerAld_3-P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020829">
        <property type="entry name" value="GlycerAld_3-P_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020828">
        <property type="entry name" value="GlycerAld_3-P_DH_NAD(P)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006424">
        <property type="entry name" value="Glyceraldehyde-3-P_DH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43148">
        <property type="entry name" value="PTHR43148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02800">
        <property type="entry name" value="Gp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00044">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000149">
        <property type="entry name" value="GAP_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00078">
        <property type="entry name" value="G3PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00846">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01534">
        <property type="entry name" value="GAPDH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00071">
        <property type="entry name" value="GAPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gp_dh_N" evidence="10">
        <location>
            <begin position="2"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Glyceraldehyde 3-phosphate binding" evidence="5">
        <location>
            <begin position="151"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Glyceraldehyde 3-phosphate binding" evidence="5">
        <location>
            <begin position="210"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="11"/>
            <end position="12"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Activates thiol group during catalysis" evidence="7">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-2"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR000149-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AKH84474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="332" mass="34828" checksum="F0ADDFAD00E53C5A" modified="2015-07-22" version="1">MTRIAINGFGRIGRNVLRALLERDSSLDVVAVNDLAEPAALARLLAYDTTAGRLGRPVTADGDTLVVDGRRIKVLAEREPAKLPWADLGVDVVLEATGRFTAATAARAHLDAGARKVLVSAPSAGADVTLAPGVNTGAYDPQAHTIVSNASCTTNALAPLAAVLDELAGIEHGFMTTVHAYTQEQNLQDGPHRDARRARAAAVNIVPTTTGAAKAIGLVLPGLDGRLSGDSIRVPVPVGSIVELNTTVARDVTREDVLAAYRTAAEGPLAGILEYSEDPLVSADITGNPASAVFDSALTRVDGRHIKVVAWYDNEWGFSHRVIDTLELLTTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAP5</accession>
    <name>A0A0F7NAP5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_26215</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018382.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH85141">
        <property type="protein sequence ID" value="AKH85141"/>
        <property type="gene ID" value="AA958_26215"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_26215"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5518"/>
    <dbReference type="OrthoDB" id="1439158at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012914">
        <property type="entry name" value="PucR_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07905">
        <property type="entry name" value="PucR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PucR" evidence="2">
        <location>
            <begin position="7"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_30" evidence="3">
        <location>
            <begin position="571"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH85141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="629" mass="63775" checksum="45D9010ECAD571B1" modified="2015-07-22" version="1">MPTLASLVRHPTLKLSVLTGADELDVAVRWAQTSELIDPVPYLEGGELILTTALKLDVEDAEAMRRYMRRLADAGVVGVGFGVGVNVETVPEALLAAAREARVPLLEVPRTTPFIAISKVVSAAIAADQYRSLTRGFEAQRDLTRAALGAEGPATVVSRLAAHVRGWAALYDTAGEVLAVSPAGAAARAEALKGDVARLRRRPAPASAVVAGVRAEEPADAEPAGPADAGGGGAVAEGTAAEGAVAEGAVAEGAVVEGTPADGAASDGAAGAAPEAAADAPPGRAGDAARGAGHAPDRPARDAAGPAEDRVELQSLGSGRRCCGVLAVGTDGKLGPAERYAVHAAVSLLTLVTERSSAFSAAEQRLGTAVLRLLLAGQPDHARSVAGPLYGGLLDAPVRLLVAEAAAPVAPVGEGEPEPLPEALGELADALDAAAAGSGEAFLAVPDAGRLVVLATDGGAVAEAAVQHAGRVEAAHPGAVGQARGSGAGQGTLPLVAGVSAPAGPAVVTVAYKQAEQALSVARRRGRVLVEHEDVTAGSVVDLLADDAVQAFADGTLRALREHDERGRGDLVASLRAWLSRHGQWDAAAADLGVHRHTLRYRMRRVEEILGRSLDDPDTRMELWLALKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAT4</accession>
    <name>A0A0F7NAT4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_18185</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017117.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_18185"/>
    <dbReference type="EnsemblBacteria" id="AKH83817">
        <property type="protein sequence ID" value="AKH83817"/>
        <property type="gene ID" value="AA958_18185"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_18185"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3823"/>
    <dbReference type="OrthoDB" id="1220708at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031460">
        <property type="term" value="P:glycine betaine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005892">
        <property type="entry name" value="Gly-betaine_transp_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01186">
        <property type="entry name" value="proV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0129">CBS domain</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="2"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="7">
        <location>
            <begin position="311"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH83817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="387" mass="42008" checksum="1921D673F40136AC" modified="2015-07-22" version="1">MIRFEHVTKRYPDGITAVDDLSFDVAEGELVTLVGPSGCGKTTTLKMVNRLIEPTSGRIEVDGQDVMAADPVELRRHIGYCIQNVGLFPHKNVLDNTATVPHLLGTPRDKRLKRAAELLELVGLDPHEHGRRYPDQLSGGQRQRVGVARALAADPPVLLMDEPFGAVDPVVREHLQNEFLKLQARMRKTVLFVTHDIEEAVRLGDRIAVFGNGKIEQLDSPAAVLGAPATPYVADFVGADRGLKRLSVTEIELGDLEQPPVVRLDDDARGAAAALRDGGARWAVVLDGEGELHGWVAADEIAKGGAVSDYARRMDAWLPLGASLKKAFATMLQYDAGWIAVVDDEQTGRFAGVLTPASLHEALRRSIDADARAVARAEVELDSLPQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NB13</accession>
    <name>A0A0F7NB13_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_18470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017160.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_18470"/>
    <dbReference type="EnsemblBacteria" id="AKH83862">
        <property type="protein sequence ID" value="AKH83862"/>
        <property type="gene ID" value="AA958_18470"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_18470"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3877"/>
    <dbReference type="OrthoDB" id="922446at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH83862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="277" mass="31231" checksum="C643E88DF5490B1F" modified="2015-07-22" version="1">MAVMSSLVIPYATYLRVYEPLAAFPEPERTHWYRYAAREAAPTSQDELLRALAGLAGTPPTAAPAHESGDAFVADVDGVTCVCPWRTRLRSWLALDELVEELPKPVLEAALPEVVREQALADHARWRVENPDARPWIRSAVWTVPMRWFVLFSDEEREYETGERTLLRYRTPMVQARRRVARGLKALRDAVGQAPLVEGLVDVGKWLEEFHPRSLVELDYGGLVHVLPKEHLAEDRSAAEVAEGIAALAAGDEERAGRAYQRLTDRWGVVRERQFAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NB41</accession>
    <name>A0A0F7NB41_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_23435</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017924.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_23435"/>
    <dbReference type="EnsemblBacteria" id="AKH84669">
        <property type="protein sequence ID" value="AKH84669"/>
        <property type="gene ID" value="AA958_23435"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_23435"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4940"/>
    <dbReference type="OrthoDB" id="332732at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022791">
        <property type="entry name" value="L-PG_synthase/AglD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03706">
        <property type="entry name" value="LPG_synthase_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00374">
        <property type="entry name" value="TIGR00374"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="248"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="272"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="629"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="660"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="695"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="737"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="771"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="821"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="850"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="896"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="557"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="27"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH84669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="928" mass="99013" checksum="A2630FB8B5C6F83D" modified="2015-07-22" version="1">MRRDSAAEPPPAEPAAEAQSAARPDGQARPEGRDGRDERARPGPYDEHDADRGDSPDHPRGLYDTPRPHSPATARYDSRRRTAPGPIEGDDPLLPARVHRPSDLMRLLLGILGIAAVLGLAAVAHGTTEGLEEDITKGAEYTPSFVVTLGGLTSSIAVLIVPVAFAVERLVKRDGLRIADGVLAAVLAHGAGLAVSLWVSEAAPGSVQGALTQIARDGERTDPVHGYLAPVIAYMTAVGMARHARWRVLMWTVLVLDGLAVLVGGYTTPFAILLTVLIGWTVAYGTMYAVGSPNVRPTGRNLLAGLRRVGFRPVSALVPEEQPDLEGDGRGRRFVVTLEDGPPLDVTVVDREQQAQGFFYRAWRRLSLRGVYQRRSMQSLRQALEQEALLSYAAIAAGANAPKLIATSDLGPDAVMLVYEHTGGRPLASVADEVITDLLMRESWRQVRALQSRRIAHRRLDADAVLVTRSGKVILTDLSNGDIAAGDVVLRMDIAQLLTTFALRVGAERAVAAAVEVLGPDAVADALPLLQPIALTRDTRAELRRLSRERAAREREAVIEASRSRKHQAAGDRKSMRAAKQAEKRAIEGALDEAREEDVLTQIRQHVLLIRPQAPVEPVRIERIRPRTLVSIIAGVFAAYFLLTQLTHVKVDDVLAQANWRWAALAALFSSATYLAAAMSLLGFVPERVPYGRTVLAQVAASFVKLVAPAAVGGVALNTRFLQKSGVRPGLAVASVGASQLFGLGSHILLLLTFGYLTGTERTPSLSPSRTVIAGLLAAAVLILIITAVPFLRKAVSSRIRSLFAGVVPRMLDVLQRPQKLAAGIGGMVLMTLSFVLCLDASVRAFGGDLSFASVAVVFLAGNALGSAAPTPGGVGAVELALTAGLTAAGMPSDTALSAVLLFRLLTFWMPVLPGWLSFTHLTRKGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NB74</accession>
    <name>A0A0F7NB74_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Alpha-ketoglutarate decarboxylase</fullName>
            <ecNumber evidence="15">4.1.1.71</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">kgd</name>
        <name evidence="15" type="ORF">AA958_23935</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(R)-N(6)-dihydrolipoyl-L-lysyl-[2-oxoglutarate dehydrogenase complex component E2] + succinyl-CoA = (R)-N(6)-(S(8)-succinyldihydrolipoyl)-L-lysyl-[2-oxoglutarate dehydrogenase complex component E2] + CoA</text>
            <dbReference type="Rhea" id="RHEA:15213"/>
            <dbReference type="Rhea" id="RHEA-COMP:10581"/>
            <dbReference type="Rhea" id="RHEA-COMP:10582"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="ChEBI" id="CHEBI:83120"/>
            <dbReference type="EC" id="2.3.1.61"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(R)-N(6)-lipoyl-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase] + 2-oxoglutarate + H(+) = (R)-N(6)-(S(8)-succinyldihydrolipoyl)-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase] + CO2</text>
            <dbReference type="Rhea" id="RHEA:12188"/>
            <dbReference type="Rhea" id="RHEA-COMP:10483"/>
            <dbReference type="Rhea" id="RHEA-COMP:10484"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83120"/>
            <dbReference type="EC" id="1.2.4.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate metabolism; tricarboxylic acid cycle; succinyl-CoA from 2-oxoglutarate (dehydrogenase route): step 1/1.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.71" evidence="15"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_23935"/>
    <dbReference type="EnsemblBacteria" id="AKH84753">
        <property type="protein sequence ID" value="AKH84753"/>
        <property type="gene ID" value="AA958_23935"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_23935"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5044"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00997"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004149">
        <property type="term" value="F:dihydrolipoyllysine-residue succinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004591">
        <property type="term" value="F:oxoglutarate dehydrogenase (succinyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032106">
        <property type="entry name" value="2-oxogl_dehyd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011603">
        <property type="entry name" value="2oxoglutarate_DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031717">
        <property type="entry name" value="KGD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042179">
        <property type="entry name" value="KGD_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23152">
        <property type="entry name" value="PTHR23152"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16078">
        <property type="entry name" value="2-oxogl_dehyd_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16870">
        <property type="entry name" value="OxoGdeHyase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000157">
        <property type="entry name" value="Oxoglu_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00239">
        <property type="entry name" value="2oxo_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="15" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Transket_pyr" evidence="14">
        <location>
            <begin position="920"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="59"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1235"/>
            <end position="1255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="102"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00033664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AKH84753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="1269" mass="139373" checksum="69ADBD83171B7529" modified="2015-07-22" version="1">MSSQSPKSSSSSVRTEEPSQGRDPAAAFGPNEWLVDEIYQQYLQDPNSVDRAWWDFFADYKPGTAGGNQGAATQTAQPPPAAPPAPAQAAPAAHAAPAQAPAAPPQQAPAPAAPPAVDGRPVARPPARPAAKPAKPATPAPAAAPEGPELVTLRGPAAAVAKNMNASLELPTATSVRAVPVKLLFDNRIVINNHLKRARGGKVSFTHLIGYAMVQAMKLMPSMNHSFAEKDGKPTLVKPEHVNLGLAIDLVKPNGDRQLVVAAIRKAETLNFFEFWQAYEDIVRRARSNKLTMDDFTGVTCSLTNPGGIGTVHSVPRLMPGQSMILGVGAMDYPAEFQGTSQDTLNKLGVSKVMTLTSTYDHRVIQGAASGEFLRIMHQLLLGENDFYDEVFKSLRIPYEPVRWLRDIDASHDDDVTKAARVFDLIHSYRVRGHVMADTDPLEYKQRKHPDLDVTEHGLTLWDLEREFAVGGFAGKSMMKLRDILGVLRDSYCRTTGIEYMHIQDPKERKWIQERVERPHDTPEREEQLRILRRLNAAEAFETFLQTKYVGQKRFSLEGGESVIPLLDAVIDAAAESRLDEVVIGMAHRGRLNVLANIVGKSYAQIFREFEGNLDPKSMHGSGDVKYHLGTEGTFTGLDGEQIKVSLTANPSHLEAVDPVLEGVVRAKQDIIGKGGTDFTVLPLALHGDAAFAGQGVVAETLNMSQLRGYRCGGTVHVVINNQVGFTAPPESARSSMYATDVARMIEAPIFHVNGDDPEAVVRVARLAFEYRQAFNKDVVIDLICYRRRGHNEGDNPQFTNPQMVELIDKKRSVRKLYTESLIGRGDITMEEAEQALQDFQGQLEKVFTEVRDATETPAPAEVPPHALPGFPVAVETAVSEEVVKRIADSQVSLPDQVSVHPRLLPQLQRRVAMVEDNTIDWGMGETLAFGSLLMEGTPVRLAGQDSRRGTFGQRHAVLVDQKTGEDYTPLNYLAPDQARYNVYDSLLSEYAAMGFEYGYSLARPDSLVLWEAQFGDFVNGAQTVVDEFISSAEQKWGQSSGVVLLLPHGYEGQGPDHSSARIERFLQLSAQNNMTVAMPTLPSSYFHLLRWQVHNPHHKPLVVFTPKSMLRMKAAASRTDEFTSGGFRPVIGDDSVEPAAVRKVVFCSGKVYYDLDAERQKRGAQDTAIVRLERLYPLPGTEIQAELARYSGASTFVWAQEEPANQGAWPFIALNLVDHLDLIIGSGPVPNADRLRRVSRPSSSSPAVGSAKRHQAEHAQLMAEVFDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBA1</accession>
    <name>A0A0F7NBA1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4097 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_23885</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017996.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_23885"/>
    <dbReference type="EnsemblBacteria" id="AKH84744">
        <property type="protein sequence ID" value="AKH84744"/>
        <property type="gene ID" value="AA958_23885"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_23885"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5033"/>
    <dbReference type="OrthoDB" id="1840400at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025164">
        <property type="entry name" value="DUF4097"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13349">
        <property type="entry name" value="DUF4097"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4097" evidence="2">
        <location>
            <begin position="151"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH84744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="300" mass="30638" checksum="AA551225870F8EAC" modified="2015-07-22" version="1">MSVQLVADPQTLAFEEPVTALKVRIVNGAVHVVGTHDDAGRPGAARLEVSEIEGPPLRVSLENGELTVAYEDLPWRGFLKWLDRKGWRRRVVVSLAVPATARVEVGVVGADAVVSGIAGRTDVRGVSGGATLVGLSGPVRADTVSGELEAQALEGDLRYNSVSGPLTLIDGAGGSVQADTVSGDMVIDLSPAARAADVRVNTVSGEIAVRLPEEPDVEVHASTTSGAVSNAFPALDVSGQWGAKSVDGRLGAGKGSLKVTTVSGGLALLRRPEGVDDEPEDAPPGAGPADSAGPSDKKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBP9</accession>
    <name>A0A0F7NBP9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Threonine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AA958_20325</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + H(+) + L-threonyl-tRNA(Thr)</text>
            <dbReference type="Rhea" id="RHEA:24624"/>
            <dbReference type="Rhea" id="RHEA-COMP:9670"/>
            <dbReference type="Rhea" id="RHEA-COMP:9704"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78534"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="6.1.1.3" evidence="2"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017431.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_20325"/>
    <dbReference type="EnsemblBacteria" id="AKH84142">
        <property type="protein sequence ID" value="AKH84142"/>
        <property type="gene ID" value="AA958_20325"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_20325"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4281"/>
    <dbReference type="OrthoDB" id="900765at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004829">
        <property type="term" value="F:threonine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006435">
        <property type="term" value="P:threonyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00771">
        <property type="entry name" value="ThrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002320">
        <property type="entry name" value="Thr-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033728">
        <property type="entry name" value="ThrRS_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451">
        <property type="entry name" value="PTHR11451"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01047">
        <property type="entry name" value="TRNASYNTHTHR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00418">
        <property type="entry name" value="thrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="8">
        <location>
            <begin position="29"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH84142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="419" mass="44982" checksum="E03360663A4E8732" modified="2015-07-22" version="1">MKDHRRLGRELGLFGTDPLIGAGLPYWLPAGAAVRQALEEYVADVEHRAGYQRVYSPVLGKRELYELSGHWEHYRDDMFPPMRLGGGPDGCSAGEEVVLRPSLCPHHALIYRSRERSYRELPLRIAELGGMYRAELSGVLGGLTRVRAIQLNDAHVFCTLEQVADEALAALRLIREAYAAMGLAAARYRLSLPGPGAKYVRDPGLWRRAGALLEQALAAAGIDYEAEEGEAAFYGPKIDVQVLDAAGREATLSTVQVDFHQPARFGLAYVGADGGRHRPVMVHRSVVGSAERAVAQLVEVHQGAFPPWLAPVQAVVLPVGEAEAAPAEALLRRCVAAGLRAELAGPERGTLGARVRGARLAPYQVVVGAREAAGGAAALRLRDGRRPAPLPAAEAVARMAAAVAARRPELWPDEGEAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBR4</accession>
    <name>A0A0F7NBR4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription termination factor Rho</fullName>
            <ecNumber evidence="8">3.6.4.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">ATP-dependent helicase Rho</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rho</name>
        <name evidence="12" type="ORF">AA958_24800</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homohexamer. The homohexamer assembles into an open ring structure.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the Rho family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="8"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018140.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_24800"/>
    <dbReference type="EnsemblBacteria" id="AKH84888">
        <property type="protein sequence ID" value="AKH84888"/>
        <property type="gene ID" value="AA958_24800"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_24800"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5229"/>
    <dbReference type="OrthoDB" id="1619125at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008186">
        <property type="term" value="F:ATP-dependent activity, acting on RNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04459">
        <property type="entry name" value="Rho_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01128">
        <property type="entry name" value="rho_factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01884">
        <property type="entry name" value="Rho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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        <property type="entry name" value="Rho_factor_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011112">
        <property type="entry name" value="Rho_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036269">
        <property type="entry name" value="Rho_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011113">
        <property type="entry name" value="Rho_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004665">
        <property type="entry name" value="Term_rho"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46425">
        <property type="entry name" value="PTHR46425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07498">
        <property type="entry name" value="Rho_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07497">
        <property type="entry name" value="Rho_RNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00959">
        <property type="entry name" value="Rho_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68912">
        <property type="entry name" value="SSF68912"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00767">
        <property type="entry name" value="rho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51856">
        <property type="entry name" value="RHO_RNA_BD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1 8" id="KW-0806">Transcription termination</keyword>
    <feature type="domain" description="Rho RNA-BD" evidence="11">
        <location>
            <begin position="292"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="80"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="80"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="110"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="161"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="236"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="410"/>
            <end position="415"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="422"/>
            <end position="427"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="453"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AKH84888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="667" mass="71602" checksum="1C31263E6EE4BB8F" modified="2015-07-22" version="1">MSDTTDLMGVNAENAASPASGGASQQETGGAPATTAGSTRRRRGAGLEGMVLAELQQIASGLGIRGTARMRKSQLIEVIKERQGADGGKPAEAKAEKAADKAGKDAQADGGAARPKRRATSRARTDAAEQAEGDGRGDDGDSRIDIPGQPVKMQDAGAEQNGGEKADKAEKADKADKAEKAEKADKAAEKTGDAKQSGDGGRQKGDRQGGGDRQGGGRRDRQNRRNKGDDGGGQGGGGGQQNQGGGRQQQQQQDDDFDGGRRGRRGRYRDRRGRRGGREDYSEPQIAEDDVLIPVAGILDILDNYAFVRTSGYLPGPNDVYVSLAQVRKNGLRKGDHVTGAVRQPRDGERREKFNALVRLDSVNGQGPEQSRGRAEFGKLTPLYPQDRLRLESDPGALTPRIIDLVSPIGKGQRGLIVAPPKTGKTMILQSIANAITTNNPECHLMVVLVDERPEEVTDMQRSVKGEVISSTFDRPAEDHTTVAELSIERAKRLVELGHDVVVLLDSITRLGRAYNLAAPASGRILSGGVDSTALYPPKKFFGAARNIEDGGSLTILATALVETGSRMDEVIFEEFKGTGNMELRLDRKLSDKRIFPAVDVDASGTRKEEILMGSDELAIVWKLRRVLHALDQQQAMELLLDKMKQTKSNAEFLLQIQKTTPTPNGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBW3</accession>
    <name>A0A0F7NBW3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_29535</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018920.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_29535"/>
    <dbReference type="EnsemblBacteria" id="AKH85691">
        <property type="protein sequence ID" value="AKH85691"/>
        <property type="gene ID" value="AA958_29535"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_29535"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6233"/>
    <dbReference type="OrthoDB" id="847145at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007213">
        <property type="entry name" value="Ppm1/Ppm2/Tcmp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016874">
        <property type="entry name" value="TcmP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04072">
        <property type="entry name" value="LCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028177">
        <property type="entry name" value="Polyketide_synth_Omtfrase_TcmP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH85691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="278" mass="30313" checksum="C9AD82381AECD799" modified="2015-07-22" version="1">MTRYEADLGTVQETLLIPLYGRAVESRKAEPALRDPRAEEIVASLDYDFARFDGLPSLAGTVLRTALFDAWVRDFLTAHPDGTVVEIGAGLNTRFERVDNGTARWLEFDLPDVIALRRKLFADTGRRRAAAASVTGASWADEAVVLGGEGPYFLAAEAVLPFLTETEAHGVVDLIAARFPGSLLALDTAGPGIVGAQESHDALSKVEARMRWACADPAEVADWCPGARLLASHTLTSLPQHMHQALPAAYREMLATLAEHHLTQVEEYRLNLLRLPHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCE2</accession>
    <name>A0A0F7NCE2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_30680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019084.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_30680"/>
    <dbReference type="EnsemblBacteria" id="AKH85856">
        <property type="protein sequence ID" value="AKH85856"/>
        <property type="gene ID" value="AA958_30680"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_30680"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6484"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010343">
        <property type="entry name" value="ArAE_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06081">
        <property type="entry name" value="ArAE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="392" mass="42691" checksum="77A72288FF91E146" modified="2015-07-22" version="1">MAGLVERLRAPAVAQTVRATMAATIAYVVALQLTNGPKPLTAPLTALLVVQVTFYATLTTGIRRVTAVVVGVLIASGFSALVGLSWWSLGLIIVSSLVAGRIVRVSEFVPEVAISAMLVLGVAHVEDTAFTRILETLTGAAVGLTFNLVLAPPVWVESAGDAIEDLARRMRRLLLRSTEQLTEVTPPSVAADRLEAARELDEFVGEVDTSLRRAEDSLRLNPRVREGLMHRAVLRTGLDTLEICAVVLRVLTRSLSDLAHARRKGEPLFPRDAGAALQDLFAYLGDALVSFAQLVATEVSESAETAAGRLEADLSAARSVRDRVESLLLETVGRDEENWFLYGALLADVNRVLDELDTEHRSARLLEALDRSSRDYRERIPRLSRLSAWLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCH4</accession>
    <name>A0A0F7NCH4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">zf-CGNR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_30905</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019119.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH85891">
        <property type="protein sequence ID" value="AKH85891"/>
        <property type="gene ID" value="AA958_30905"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_30905"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6531"/>
    <dbReference type="OrthoDB" id="1478254at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010852">
        <property type="entry name" value="ABATE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023286">
        <property type="entry name" value="ABATE_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021005">
        <property type="entry name" value="Znf_CGNR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35525">
        <property type="entry name" value="PTHR35525"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07336">
        <property type="entry name" value="ABATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11706">
        <property type="entry name" value="zf-CGNR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160904">
        <property type="entry name" value="SSF160904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-CGNR" evidence="1">
        <location>
            <begin position="154"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="199" mass="21147" checksum="4773A0F2A5F9C860" modified="2015-07-22" version="1">MPESPTGDFTATPAPGAADYPSLDFVNSAMALPGGQFTDLLGTPADANRWLTGHGLAPADAGIREMCAAQLRSLREHLRVLFAARAEGLPALPAALAAVNDALSRAPTAALLYWDEKNGPYRAAPCPTNEILDRALAVLAADAADLLTAPDADRLTRCGSSPCNRYLLRHGRRHWCSTRCGDRARAARAYARRTRPDGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCH7</accession>
    <name>A0A0F7NCH7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AA958_30930</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH85896">
        <property type="protein sequence ID" value="AKH85896"/>
        <property type="gene ID" value="AA958_30930"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_30930"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6537"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028081">
        <property type="entry name" value="Leu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13458">
        <property type="entry name" value="Peripla_BP_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="15"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="271"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="333"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="480"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="345"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="442"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH85896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="911" mass="92324" checksum="A491FEB6CB9500E1" modified="2015-07-22" version="1">MRALRADDPDELGGHRLLARLGAGGMGVVYLARAGDGTLVALKVIRPEHAANPAFRARFRREVRLATGLTGRWVVPVTAADAEARAPWLATAFVPGPALVEAVDGYGPLPPYAVSALGARLAEALAEVHAAGLVHRDVKPGNVLLALDGPRLIDFGIAHDSGATALTAPDAVIGTPGYLAPEQIRAGGRAGPPSDVFALGCVLAYAATARRPYGTGNPAAVLYRTVHEAPDLAGLEVLPRGLRAAITACLAKAPDDRPTAAELRTALAAEPGAAASRAPGDASAAPAEGPVDPRVPAPPPPDAATRVLRDQVAGEAGEGGPASETLPYEATEAAGHGAAGRWTEADELAGERRAVDDRGAGGRESGGNADDPQGREDGSADGPPAADGAGEARPSGVRAADRPGDTGPPAPERPAAGARAADGAGDPRLPRARAADRPGDPAPRIPAAPPPAPVAGLPAGPHDWLPSPVLRLVAERSARALDPPPRQSALAGAAPPGAADTVTAGRHGPSRRRFLVGGAAAVLTAAGGGAAALFRDGNGGGDGGASPRLPTHPIALHAALTGDQSAVGVAHERGARLAVALHNARDGARYRLALVPYDDRGDPGRAEDVARQVLGERSFRAVLGPTTAGTLRAALPLYGEESLAAVNVSVDTEAVGVGRTDAPSLVGTRLSGAYHTHPVLDYLTRVRGVVRTAVVQDAAAGGEVQGVVDTLRESPPGEGEASFHPVAAADGFGAAVAAALARRPEAVVYAGASPGRAASCARALAAAGFDGPRTSFEPVMRPAFLREAGAAAEGWVFGAPYTAAEQATSKAARAFTAAYRERYDGPPPRWAAEAYDAVGLIAAALDALGGGTEIVPGQVAERIVEVSHAGVAKPLRFTADLVHMLEPSRTAFLYEAHNGAFRFLGRHDQVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCI8</accession>
    <name>A0A0F7NCI8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein mbtH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_32755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019427.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_32755"/>
    <dbReference type="EnsemblBacteria" id="AKH86200">
        <property type="protein sequence ID" value="AKH86200"/>
        <property type="gene ID" value="AA958_32755"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_32755"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6920"/>
    <dbReference type="OrthoDB" id="2067093at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005153">
        <property type="entry name" value="MbtH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038020">
        <property type="entry name" value="MbtH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037407">
        <property type="entry name" value="MLP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38444">
        <property type="entry name" value="PTHR38444"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03621">
        <property type="entry name" value="MbtH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00923">
        <property type="entry name" value="MbtH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160582">
        <property type="entry name" value="SSF160582"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MbtH" evidence="1">
        <location>
            <begin position="6"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="74" mass="8531" checksum="ACDFCCEBB67FC129" modified="2015-07-22" version="1">MTHATNPFEDDEARFLVLVNDEGEHSLWPAFAEVPRGWRVALSEDTRQACLEYVERTWTDMRPRSLAEPVDGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCJ0</accession>
    <name>A0A0F7NCJ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Branched-chain amino acid transporter AzlD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_26525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018432.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_26525"/>
    <dbReference type="EnsemblBacteria" id="AKH85194">
        <property type="protein sequence ID" value="AKH85194"/>
        <property type="gene ID" value="AA958_26525"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_26525"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5582"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008407">
        <property type="entry name" value="Brnchd-chn_aa_trnsp_AzlD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05437">
        <property type="entry name" value="AzlD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="102" mass="10106" checksum="E62F526A38D27D93" modified="2015-07-22" version="1">MTTWLAIGLTFAGCYAVKLLGLSVPSGALERPLVRRLAALLPVALLAALTAQQTFADGTALVLDARAAGLAAAGAALLLRAPFLVVVAAAVVVTAAVRAVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCQ3</accession>
    <name>A0A0F7NCQ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Flagellar motor protein MotB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_31430</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019209.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_31430"/>
    <dbReference type="EnsemblBacteria" id="AKH85981">
        <property type="protein sequence ID" value="AKH85981"/>
        <property type="gene ID" value="AA958_31430"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_31430"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6641"/>
    <dbReference type="OrthoDB" id="1812435at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
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    </dbReference>
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        <property type="entry name" value="SSF49879"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0966">Cell projection</keyword>
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    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="38"/>
            <end position="89"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH85981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="256" mass="28671" checksum="81855F56A52B95F7" modified="2015-07-22" version="1">MTLRESLARGAAPSPPGTLHARSVAGGIRVPPGAERVVRFGRDKDEVDLCVGEDDLRVSRRHGELSYQRSTWWLRNTGQQLVRLPRGRLMHLSTEPIPLAPGYTPLFVKGSGHREHLVELYVTDAGEDGRVPRHRAETLPPKRWTLSREERLVLVVLGQQYLQYESDPRPLSYRQAAELLAFLPGAEGITKRVIEHRVEDVRRRLARGGFPYQVTRGDDGGGPSDSVLKHNLLRGLVESTTLVPPDLELLDDYLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDD2</accession>
    <name>A0A0F7NDD2_9ACTN</name>
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            <fullName evidence="7">Transporter</fullName>
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    <gene>
        <name evidence="7" type="ORF">AA958_01995</name>
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    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
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    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EnsemblBacteria" id="AKH86500">
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        <property type="gene ID" value="AA958_01995"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_01995"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.431"/>
    <dbReference type="OrthoDB" id="1210653at2"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
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            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="122"/>
            <end position="141"/>
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    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="193"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
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        <location>
            <begin position="268"/>
            <end position="285"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="291"/>
            <end position="314"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
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        <location>
            <begin position="351"/>
            <end position="374"/>
        </location>
    </feature>
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            <begin position="1"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH86500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="385" mass="38871" checksum="C63010D6C9BBBA5F" modified="2015-07-22" version="1">MLFAVACGAAVANVYFSQPLLVAMGDDLAMSPGLVGGIVTLTHVGYGLGLFLLVPLGDMADRRRLVVAQLLLLVVALTVVAAAPTAAVLLAGTAAMGLLAVVTQTLVAFAASLAPPAARGRVVGLVTGGVVIGILLARTVSGVLADLAGWRSVYLASASLTALLALVLHRVLPRHGATPPATLRYGQLLRSTVTLFAGEPLLRLRALFGLLVFAAFSTLWSSVARPLSEEPYPLSHSAIGMLGLIGVVGALAASAAGRLHDRGLSGRTTGAALALLAVSWLPLAFTGSSPGALVAGVILLDLAVQAVHVTNQTLIYALRPDAGSRLIGGYMVFYSVGSATGAIAATSLYAAAGWGAVCALGAGFSGLGFVLWAATRRGAAAARRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
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    <name>A0A0F7NDD4_9ACTN</name>
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        </submittedName>
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    </gene>
    <organism evidence="3 4">
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        <lineage>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
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    <dbReference type="EnsemblBacteria" id="AKH86256">
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    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_33095"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6992"/>
    <dbReference type="OrthoDB" id="1900342at2"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
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            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH86256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="204" mass="21148" checksum="C43087B61456C037" modified="2015-07-22" version="1">MSVTTYPKTPAGESAPGNGPARALLRRWPTALALALTVPGLFSGGDGDPDGAVDAFGEALPLLPLLYLIVAQAGRPRWTWPVLGAGVAVMVALRTTGLVAPSTVLVAVAAGLLLWGAVRGTPHGGAVFWLQSAGAVLFCGLAVAGLAVDPDLGRYLVAAGWFFHGVWDFVHLRMRGLDGIVSRTFAEWCGVVDVVIAAELLFAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDH4</accession>
    <name>A0A0F7NDH4_9ACTN</name>
    <protein>
        <submittedName>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_28195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AKH85474">
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        <property type="gene ID" value="AA958_28195"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_28195"/>
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            <end position="451"/>
        </location>
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        <location>
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            <end position="693"/>
        </location>
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        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
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        </location>
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            <end position="161"/>
        </location>
    </feature>
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            <end position="220"/>
        </location>
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            <end position="363"/>
        </location>
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            <end position="411"/>
        </location>
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    <feature type="compositionally biased region" description="Pro residues" evidence="1">
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            <begin position="638"/>
            <end position="653"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="765" mass="78630" checksum="56FE8701F0B08C8F" modified="2015-07-22" version="1">MDRQGETAGERRTEDEWWHDLYEEGVPDTGPQRAGDTLDDRFASVARAVDEEADPAPPGAAGSSSPSRPSRPSAAEPYDQMQDPDYPPPPASSTPPPSVAGVPGFTERAEPAGRGWADDVFAGLREDDGPVPRPAERVQDRKPEPDRKPEPDRKPEPEPEPEPVEPPGPAAEAAALWWDSADGDRPASAPSPPAPRETAERAPAEEALPDREEPEAELRDTPPPADVAPPGAEEAAGPAPADAALPGSADTGEPAPAAPAPAPRASAAPAPGQRAPGAPESPAPAPPPARPEPAGSEQPAPPAPASAEPGPGRAVPPGPGRRGPAQPAAGPSVPPAAPAPVPPPRPVRPAAERPAPPTPAAGSGPGQAAPSASAQPARPEPLPSVSASPAPVPPAPPPRAGSAPQPDTEEPPPATMRLRQVSVTDTLTDVEWARRGGESVGGGPPTYEAEPTALPEVAPGALADLVPDTVLDGARYGSFTLRAASTRGDSPRYRGEQRRDALLTARFGGGEDALVFVAVATGARGVPRTDRAADSLVRWMGEAVGRSRARLSEDMRTGRRAALKGGLHRLTGRTYGLMRAQAEEFGVDPAGYTAGLRCLLLSADPRCRTRVFFGTGTGGLFRLRGDEWQDLEPAPPEEGAAQAPPPAPGPPADPRLTVDLGVQPQRSAPAGPPPPGFGALVDTPDPGEPAPFAFRASEGRPGDVLLLCSPGFAEPLRGAPGLAAELGERWRGEEAPPGLAAFLGDVQLRAKGFADDRTAAALWES</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDI2</accession>
    <name>A0A0F7NDI2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_05050</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019791.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-0472">Membrane</keyword>
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        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
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        <location>
            <begin position="39"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH86555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="126" mass="12700" checksum="19B3DBD98458D5F7" modified="2015-07-22" version="1">MGIPLVLTAMPEFGMFSVGAVAAAVTAGLGGGLVVQVIVFAVVSTALIAAVRPVARRHRGQGGATTGTDALKGRQAVVLERVDGTGGRIKLAGEVWSARALDSGEVYEPGRTVDVVDIDGATAVVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NEN2</accession>
    <name>A0A0F7NEN2_9ACTN</name>
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        <submittedName>
            <fullName evidence="3">Peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_26385</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH85172">
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        <property type="gene ID" value="AA958_26385"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_26385"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5554"/>
    <dbReference type="OrthoDB" id="1891666at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
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    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
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        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002520010" evidence="1">
        <location>
            <begin position="35"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M23" evidence="2">
        <location>
            <begin position="64"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH85172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="172" mass="17723" checksum="E63A9C9FB358A921" modified="2015-07-22" version="1">MSKHAKFTAPIATTAMLAAGGGMVLALGSGVATADSKPDWVKPVTADYDVTGQYNQGGARWAAKHSGQDFAAPTGTKVKAASDGTVVTAGWGGAYGNNIVIKHGEGLYTQYAHLSKIDVNVGEKVNAKELIGKIGTTGNSTGPHLHFEVRTTPDYGSAVDPVAFLSKHGVKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NEP6</accession>
    <name>A0A0F7NEP6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LacI family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_31040</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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    </dbReference>
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH85914">
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        <property type="gene ID" value="AA958_31040"/>
    </dbReference>
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    <dbReference type="PATRIC" id="fig|444103.5.peg.6560"/>
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    <dbReference type="Proteomes" id="UP000034283">
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
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    </dbReference>
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    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="8"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH85914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="340" mass="37090" checksum="7A55EFD8EA251408" modified="2015-07-22" version="1">MPEAPGRLTQRDIARLAGVSQTTVSLVLNDRPDAARIAPETRERVLRVIRETGYAADPMARRLTKQLNQILGVFTYEPVFPSTSADFYHPFLRGIEESAERSGCDLLLFTSAPVTAGRRRIFHENNRLRVADGCVLLGREIPHEELSRLVAERYPFVCVGRRDDADGGPVPYIGADYVSATARLVERVRALGHRRLAFAGPGAGAESSDDRLTGFRQVAGSGAPHLGARGEPAAEQLEQLLDAGVTAVFVEFLHDAVKLYEAAAARGLDVPRDLSMLALGDPTAPVDPPVDFTGFRLRRTEMGRQAVDLLTGMLHGRAEHTRRLLDCRLVEGVTLAAPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NER3</accession>
    <name>A0A0F7NER3_9ACTN</name>
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        <submittedName>
            <fullName evidence="3">Endonuclease/exonuclease/phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_20420</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_20420"/>
    <dbReference type="EnsemblBacteria" id="AKH86925">
        <property type="protein sequence ID" value="AKH86925"/>
        <property type="gene ID" value="AA958_20420"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_20420"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4303"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Phytase-like_dom"/>
    </dbReference>
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        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13449">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phytase-like" evidence="2">
        <location>
            <begin position="55"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH86925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="356" mass="36977" checksum="A4735D8AE612F2B9" modified="2015-07-22" version="1">MLLTVSSPAAPAAPAEPAAPVEPAASPDGRPAACSPRTSLAGFSDALDKTAFAGTRVAGLSALSARGNSRVLALTDNTDADEARVYELAVRSAPGRVGAAVRDVTVLRRPDGTPYTGADFDGEGLVAEPAGTVLASSEREPSIRRFRLSDGRQTAELPVPRRFRIAPAGQAAANQTFESLTTAPDGRTLYAGLEGPLEADGHDAANRGLLRILRYGGTPGGAFAPRAQYAYRADPGLGLAELAALDRHHLLALERGYTAGVGNTVRIYRVSLHGAPDVTALPSLTEAGAGVFAAKRLLVDLADCPPSGATSPQPQPNPLLDNVEGMTLPGHRTLLLVSDDNASARQITRLYALRLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NEZ4</accession>
    <name>A0A0F7NEZ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MerR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_17105</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_17105"/>
    <dbReference type="EnsemblBacteria" id="AKH86836">
        <property type="protein sequence ID" value="AKH86836"/>
        <property type="gene ID" value="AA958_17105"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_17105"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3597"/>
    <dbReference type="OrthoDB" id="2076478at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015689">
        <property type="term" value="P:molybdate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004606">
        <property type="entry name" value="Mop_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010093">
        <property type="entry name" value="SinI_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005116">
        <property type="entry name" value="Transp-assoc_OB_typ1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03459">
        <property type="entry name" value="TOBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01764">
        <property type="entry name" value="excise"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00638">
        <property type="entry name" value="Mop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51866">
        <property type="entry name" value="MOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mop" evidence="3">
        <location>
            <begin position="57"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH86836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="123" mass="12762" checksum="7910825B3DD94430" modified="2015-07-22" version="1">MGDAAALLGVSADTVRRLVDAGKLTAERDDAGRRIIPGAALAAYAREMHRAERGSTGSSARNRFAGIVTDVHLGDVSAQVEIQAGPFRVVSMVSRESAEELGLAPGVPAVAVIKSTNVVVERP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NF31</accession>
    <name>A0A0F7NF31_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_31985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019302.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86074">
        <property type="protein sequence ID" value="AKH86074"/>
        <property type="gene ID" value="AA958_31985"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_31985"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6754"/>
    <dbReference type="OrthoDB" id="1339160at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="301" mass="31244" checksum="C5546FAC873340FD" modified="2015-07-22" version="1">MRFGLLGTGPWAERAHGPGLQAHPRAEIAGVWGRRPEAARALADRLSTRAYEDVDALLADCDAVAVALPPDVQAPLAERAAAAGCHLLLDKPVATEVAAARRVVTAVERAGVASVVFFTLRFRDETAGWLAERAGEEGWLVGRADWLSPVFAGADSPYAASPWRGEKGALWDVGPHALSMLLPVLGDVDPAVPGAVTSARGPGDTVHLTLRHASGASSTCTLSHTIPPQASGVTVELHGTPGVQTAPDRDDDGPVPAFVRAVDALLEAAESGRPDPRDVHLGLRVTEILAAAQEGLPAAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFB4</accession>
    <name>A0A0F7NFB4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Metallophosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_27675</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018621.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_27675"/>
    <dbReference type="EnsemblBacteria" id="AKH85387">
        <property type="protein sequence ID" value="AKH85387"/>
        <property type="gene ID" value="AA958_27675"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_27675"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5830"/>
    <dbReference type="OrthoDB" id="72029at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07423">
        <property type="entry name" value="MPP_Prp_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041780">
        <property type="entry name" value="MPP_PrpE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024028">
        <property type="entry name" value="PNKP_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032390">
        <property type="entry name" value="PNKP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032380">
        <property type="entry name" value="PNKP_ligase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16536">
        <property type="entry name" value="PNKP-ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16542">
        <property type="entry name" value="PNKP_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04075">
        <property type="entry name" value="bacter_Pnkp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="1">
        <location>
            <begin position="194"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="PNKP_ligase" evidence="3">
        <location>
            <begin position="478"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="domain" description="PNKP-ligase_C" evidence="2">
        <location>
            <begin position="829"/>
            <end position="888"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH85387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="888" mass="95828" checksum="7AAB7A5ED8C1F2F0" modified="2015-07-22" version="1">MSDTTPAPGTAARRLGVPDLCLVVLIGTTGSGKSTFARRHFKPTEVLSSDFCRGLVADDENDQSASGDAFDVLHYIAGKRLAAGRLTVVDATSVQPEARRQLVRLAREHDVLPVAIVLDVPESVCRERNAARPDRAGMGAHVIPRQRRELRRGLRGLQREGFRTVHHLRGTDEIDAAQVVLERRYNDLAHLTGPFDLIGDVHGCARELETLLTSLGYEDGVHPAGRTAVFVGDLVDRGPDSPGVLRRVMGMVAAGSALCVPGNHENKLGRLLHGRNVKLTHGLAETVEQLERAEEAEPGFRERVRTFVDGLVSHYVLDGGRLVVSHAGLPEKYHGRTSGRVRSFALYGDTTGETDEYGLPVRYPWAEEYRGRAAVVYGHTPTPEASWINNTLCLDTGCVFGGKLTALRWPERELVDVPAERVWYEPVKPLAAGAAGTDSAPAGTAGDRPLDLADVQGRRVVETGQHGRVAVREENAAAALEVMSRFAVDPRLLLYLPPTMAPTATSAEEGHLEHPAEAFAAYRADGVARVVCEEKHMGSRAVALVCRDAGVAEKRFGLPPGAGVTGALHTRTGRPFFPDAERTEQVVARVRDAATAAGLWEELGTDWLLLDAELLPWSLKAGGLLRQQYAAVGAASRAVFPGALAALEATRTRLAAAAPAVPPAAGTDPATASDSGPVTALAALLDRQRERAADAESFSAAYRRYCWPVDGLDGVRLAPFQLLATEGRSLAGEPHDVQLALLDRLVAQDDTGLLQRTGRLYVDTGDDASVAAGVAWWQEMTAAGGEGMVVKPLQALVRSGEGRLVQPGVKCRGREYLRIIYGPEYTRPENLTRLRSRYLGHKRSLALREYALGLEALDRLAAGEPLWRVHEAVFAVLALESEPVDPRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFM2</accession>
    <name>A0A0F7NFM2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_27960</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_27960"/>
    <dbReference type="EnsemblBacteria" id="AKH87076">
        <property type="protein sequence ID" value="AKH87076"/>
        <property type="gene ID" value="AA958_27960"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_27960"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5893"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="219"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="243"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="289"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="325"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="348"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="373"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH87076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="402" mass="42174" checksum="4646E197A5A4CD78" modified="2015-07-22" version="1">MDERLTTPQGIGDSVRAAVRRTRDGDLGMLPVVAGIVVIWTIFQSLNQTFLSSTNLVNLAFEMVPLGVIALGIVCVLLVGQIDLSVGSVSGVSAAATAVVMVKHEQPMVLALAVAIAGGCVIGWLYGQILNRFGVPSFVVTLGGLLAFLGLQLWLLRDQNAINIPYDSPLVKFAQVWFVPETLAYVFAVAAAGGFLAVGWVRARSRRRAGLSSASMQWLGLRAGLLAAALLFTVFYLNRTRGVPWMFMLFVSLVLMVHYVLTKTKFGRSLYAVGGNAEAARRAGIDVRAVYTSAFVMCSALAATGGVLAAARLAAANQSTGTADVNLNAIAAAVIGGTSLFGGRGSAFAALLGVLVIQSISSGLTLLNLDSSYRFIITGLVLLVAVALDSAARRSRQAHGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFP4</accession>
    <name>A0A0F7NFP4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_29640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020525.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_29640"/>
    <dbReference type="EnsemblBacteria" id="AKH87121">
        <property type="protein sequence ID" value="AKH87121"/>
        <property type="gene ID" value="AA958_29640"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_29640"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6257"/>
    <dbReference type="OrthoDB" id="1535236at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH87121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="158" mass="16681" checksum="C64960314EA5AED1" modified="2015-07-22" version="1">MTRIGVTGHRDIPAAALESVRSGIRAALCRRSVVEALSSLAAGADQLFADIALSCGVPVTAVIPGMDYERSLGTGDTLTAYRRLLTSSVSQVRLPREASDEAAYRAAGRWIVDHVDSMVAVWDGRPARGPGGTGDVVAYAHRVGVPVTVVWSPGVRRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NG35</accession>
    <name>A0A0F7NG35_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_33835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86389">
        <property type="protein sequence ID" value="AKH86389"/>
        <property type="gene ID" value="AA958_33835"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_33835"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.7145"/>
    <dbReference type="OrthoDB" id="1392740at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="218" mass="23481" checksum="87140AF5B07C149C" modified="2015-07-22" version="1">MHEKLLRRGGGRLTHRPDDRPSAAAPARPVELVLDPAKVRGLGEGTLGAHDEAALAREVAELLPHGWDLPYKLKAALQDVIAHLGSEADLIRWLDTFPGRPRVTARIYVFLGLLDRYGDAPEVVEALREARIRKPYPEGLRDVLVPQTDSETLPDLGYRVEAALTDGKVERAAELALAIAGWLRRSLTGPVAELMGHAGEDIAQAAGEAAAPRSPAGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NG75</accession>
    <name>A0A0F7NG75_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Beta-xylanase</fullName>
            <ecNumber evidence="6">3.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AA958_29920</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-xylosidic linkages in xylans.</text>
            <dbReference type="EC" id="3.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glycosyl hydrolase 10 (cellulase F) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.8" evidence="6"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018970.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_29920"/>
    <dbReference type="EnsemblBacteria" id="AKH85742">
        <property type="protein sequence ID" value="AKH85742"/>
        <property type="gene ID" value="AA958_29920"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_29920"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6318"/>
    <dbReference type="OrthoDB" id="654705at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031176">
        <property type="term" value="F:endo-1,4-beta-xylanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044846">
        <property type="entry name" value="GH10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031158">
        <property type="entry name" value="GH10_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001000">
        <property type="entry name" value="GH10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31490">
        <property type="entry name" value="PTHR31490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00331">
        <property type="entry name" value="Glyco_hydro_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00134">
        <property type="entry name" value="GLHYDRLASE10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00633">
        <property type="entry name" value="Glyco_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="SSF50370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00591">
        <property type="entry name" value="GH10_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51760">
        <property type="entry name" value="GH10_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 6 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519616" description="Beta-xylanase" evidence="7">
        <location>
            <begin position="42"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="GH10" evidence="9">
        <location>
            <begin position="40"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B-type lectin" evidence="8">
        <location>
            <begin position="360"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AKH85742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="476" mass="50773" checksum="B84BEA026BA8BB96" modified="2015-07-22" version="1">MGSYALPRPVVRRKLRGVLLALVVCVLGAVGTLAAPPPAHAAESTLGAAAAQSGRYFGTAIASGRLGDSAYTSIASREFNSVTAENEMKIDATEPQRGQFNFSAGDRVYNWAVQNGKEVRGHTLAWHAQQPGWMQSLSGNDLRQAMIGHINGVMGHYKGKITQWDVVNEAFADGSSGARRDSNLQRTGNDWIEVAFRTARAADPAAKLCYNDYNIENWTWAKTQAVYAMVRDFKQRGVPIDCVGFQSHFNSGSPYNSNFRTTLQSFAALGVDVAITELDIQGASPTTYANVTNDCLAVPRCLGITVWGVRDTDSWRAQDTPLLFNGDGSKKPAYTAVLNALNGGSTTPPGDSGQIKGVASGRCLDVPNASTSDGTQVHLWDCHSGTNQQWAATDAGELRVYGNKCLDAAGTGNGARVQIYSCWGGDNQKWRLNSDGSIVGVQSGLCLDAAGAGTANGTLIQLYSCSNGSNQRWTLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NGI9</accession>
    <name>A0A0F7NGI9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ECF subfamily RNA polymerase sigma-24 subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_33945</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019630.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86408">
        <property type="protein sequence ID" value="AKH86408"/>
        <property type="gene ID" value="AA958_33945"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_33945"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.7168"/>
    <dbReference type="OrthoDB" id="1914729at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014325">
        <property type="entry name" value="RNA_pol_sigma-E_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02983">
        <property type="entry name" value="SigE-fam_strep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="5">
        <location>
            <begin position="15"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="6">
        <location>
            <begin position="105"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH86408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="169" mass="19818" checksum="656AC40C59FB46AC" modified="2015-07-22" version="1">MREAVREREFREFAEARQADLRRSAYLLCGDWHQAQDLTQTTLMKLYAAWGRVRRDGNVDAYARTILTRVFIDQLRRRTWREELVEEVPEAQPAPPATRELRLVMQSALRELPPRYRAVLVLRFWEDWSVEQTAEALRVSPGTVKSQSARGLRRLRQLLGTLAQEVNGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NHL6</accession>
    <name>A0A0F7NHL6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_15490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_15490"/>
    <dbReference type="EnsemblBacteria" id="AKH86798">
        <property type="protein sequence ID" value="AKH86798"/>
        <property type="gene ID" value="AA958_15490"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_15490"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3259"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="19"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="286" mass="30181" checksum="95B628FB3879AC28" modified="2015-07-22" version="1">MARRLLTAQFPRWAHLPLRPLHPGGSDHVIFRLGDAMSVRLPRGDWAAGQAEKELLWLPRLAPHLPLAVPAPLEVGEPAFGYPWHWSVSRWLDGRTATPGGLADPVEAAADVAAFLRALQGLALPSGGSSGLLSPAVPLRDRDRTTRAAIAAVDAAGAFDARALTAVWEAAVEAGERDGPPVWFHGDMHNGNLLTRGGQLSAVLDFGGLGVGDPACDLVIAWTLLDAGPRAVFRAALGADDAAWARGRGWALTTALSAYTAYAAMNPLVARNTTRQITEALADTVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NHY5</accession>
    <name>A0A0F7NHY5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3'-5' exonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_27840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_27840"/>
    <dbReference type="EnsemblBacteria" id="AKH87074">
        <property type="protein sequence ID" value="AKH87074"/>
        <property type="gene ID" value="AA958_27840"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_27840"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5868"/>
    <dbReference type="OrthoDB" id="1462689at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.80">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041605">
        <property type="entry name" value="Exo_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002121">
        <property type="entry name" value="HRDC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044876">
        <property type="entry name" value="HRDC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18305">
        <property type="entry name" value="DNA_pol_A_exoN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00570">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00474">
        <property type="entry name" value="35EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00341">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="SSF47819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50967">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HRDC" evidence="2">
        <location>
            <begin position="207"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH87074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="385" mass="41429" checksum="11B2A11C4CF09DB9" modified="2015-07-22" version="1">MPPVTADPGALAEVVRAFAAGSGPVAIDAERASGYRYGQRAYLVQLRREGAGTALIDPVACPDLSGLAAAIGDAEWVLHAATQDLPCLAEIGMRPGALFDTELAGRLAGFPRVGLGAMVENVLGYALEKGHSAVDWSTRPLPEPWLRYAALDVELLVDLRDALVEELTAQGKLRWAEEEFAAIAAAPPPEPRRDPWRRTSGMHKVRRRRQLGTVRELWTARDRIAQRRDISPGKVLADTAIVEAALAMPTSTRALAALPGFGHRMGRRQLEQWLAAVERARALPESELPQPGLPLNGPPPPRAWADKDPAAAARLSAARAAVTARAEELGLPQENLIAPDTVRRICWEPPKEPTEESVAAALTDLGARPWQITQVTPLLTAAVSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NI03</accession>
    <name>A0A0F7NI03_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_33800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019604.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_33800"/>
    <dbReference type="EnsemblBacteria" id="AKH86382">
        <property type="protein sequence ID" value="AKH86382"/>
        <property type="gene ID" value="AA958_33800"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_33800"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.7138"/>
    <dbReference type="OrthoDB" id="1261526at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="255" mass="26464" checksum="744274D2E8EA2B18" modified="2015-07-22" version="1">MTTQHAEQTPAVPKTVLVTGASSGIGEAVAARLAAEGHRVVAGARRTDRLKALAERTAAAAARTGGALEPVRLDVTDRADVEDFVSGARARHGRVDVFVANAGVMPLSRLDSLLVDEWDRMIDVNVRGLLHGIAAALPVFGAQGSGHFVTVASVGAHEVVPTSAVYSATKHAAWAITEGLRQEADPSVRVTTVSPGVVTSELAGTITDPGAAEAMRTYRAHAIAPDAIAAAVSYALSQPPEVDVNEIVVRPAHQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NI63</accession>
    <name>A0A0F7NI63_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ErfK/YbiS/YcfS/YnhG family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_21980</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020316.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_21980"/>
    <dbReference type="EnsemblBacteria" id="AKH86958">
        <property type="protein sequence ID" value="AKH86958"/>
        <property type="gene ID" value="AA958_21980"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_21980"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4629"/>
    <dbReference type="OrthoDB" id="975147at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16913">
        <property type="entry name" value="YkuD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.101.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005490">
        <property type="entry name" value="LD_TPept_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036366">
        <property type="entry name" value="PGBDSf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038063">
        <property type="entry name" value="Transpep_catalytic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03734">
        <property type="entry name" value="YkuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141523">
        <property type="entry name" value="SSF141523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="SSF47090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PG_binding_1" evidence="3">
        <location>
            <begin position="10"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="YkuD" evidence="4">
        <location>
            <begin position="95"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH86958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="208" mass="23216" checksum="A82D2744AFDF68DF" modified="2015-07-22" version="1">MLMTVGDETEQVRELQARLRAEGVFDRSPTAYYGPVTADAVSAFQEDRGLPRTGETDVVTWERLLARTDEPTRDELYPPTSQAMEKPDPRCNEGRVLCVSKRSDTLRWMKDGEVLAAMDVRFGSQYTPTREGVFEVFLKSRHHVSTLYDTPMPYAMFFSGGQAVHYSADFAANGYAGASHGCVNVRDEAKIAKLFGDVRVGDKVVVYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NIH6</accession>
    <name>A0A0F7NIH6_9ACTN</name>
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        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_06010</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mo-bis(molybdopterin guanine dinucleotide)</name>
            <dbReference type="ChEBI" id="CHEBI:60539"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019814.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_06010"/>
    <dbReference type="EnsemblBacteria" id="AKH86572">
        <property type="protein sequence ID" value="AKH86572"/>
        <property type="gene ID" value="AA958_06010"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_06010"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1256"/>
    <dbReference type="OrthoDB" id="50471at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008863">
        <property type="term" value="F:formate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02787">
        <property type="entry name" value="MopB_CT_ydeP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02767">
        <property type="entry name" value="MopB_ydeP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037951">
        <property type="entry name" value="MopB_CT_YdeP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006657">
        <property type="entry name" value="MoPterin_dinucl-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010046">
        <property type="entry name" value="Mopterin_OxRdtse_a_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041953">
        <property type="entry name" value="YdeP_MopB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43105:SF4">
        <property type="entry name" value="PTHR43105:SF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01568">
        <property type="entry name" value="Molydop_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01701">
        <property type="entry name" value="Fdhalpha-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Molybdopterin" evidence="6">
        <location>
            <begin position="120"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="Molydop_binding" evidence="7">
        <location>
            <begin position="652"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH86572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="776" mass="83814" checksum="5737189577DCE7F2" modified="2015-07-22" version="1">MAGKPPVGDPVQDAPEVTSPQQSAVGAAAIAHALRTGQEQMGVRRTARTLLRVNQRDGFDCPGCAWPDPDKPHTFEFCENGAKAVAEEATLRRVTPEFFAAHPVADLAGRSGYWLGQQGRLTHPVYLAEGAETYEQVSWERAFAIVAEELTALDSPDEAVFYTSGRTGNEAAFLYQLFAREFGTNNLPDCSNLCHESSGSALTETLGVGKGSVLLDDLHQADLIIVAGQNPGTNHPRMLTALERAKQNGARIITVNPLPEPAMVRFKNPQTVRGLARGGTPLTDLFLQVRVGGDQALFRALARRVLAAHDSGGKAVDEEFIAEHTHGYEEYAAAARGYTDADAERATGLTAADLDRAAELVLAADKIVVCWAMGLTQHKHAVPTIKEIVSFLLLGGHVGRPGAGVCPVRGHSNVQGDRTMGIFERPAPAFLDALRKEFGFDPPRHHGYDVVRAIRALRDGAAKVFFAVGGNFVSASPDTEVTEAAMRRARLTVHVSTKLNRSHVVTGARALILPTLGRTERDRQPGPDGRGHEQFVTVEDSMGVVHASRGRLAPAGDALLSEVAIICRLARAVLGEDSATPWEEFSSDYGRIRDRIARVVPGFEDFDARVRRPGGFTLPHAPRDERRFPTSTGKAHFTAGPVTYPEVPEGRLLLQTLRSHDQYNTTIYGLDDRYRGVRGGRRVVFVHPGDAADLGLADGAYADIVGEWHDGVERRADGFRVVHYPTARGCAAAYYPETNVLVPLDSTADTSNTPTSKSLVVRLEPAASTVEPDTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NJV4</accession>
    <name>A0A0F7NJV4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_27435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020455.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH87062">
        <property type="protein sequence ID" value="AKH87062"/>
        <property type="gene ID" value="AA958_27435"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_27435"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5781"/>
    <dbReference type="OrthoDB" id="2001678at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH87062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="79" mass="8388" checksum="8290F72B8A7E3FFA" modified="2015-07-22" version="1">MAAGTALLVAGCTDPPTDSSEIVTFTDGHGRVCTGSVVVDREQNEGTDYEITGLDCEYPPEGRSPGPDSYRPLPQRESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NK92</accession>
    <name>A0A0F7NK92_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SMI1_KNR4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_00070</name>
        <name evidence="3" type="ORF">AA958_34190</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86451">
        <property type="protein sequence ID" value="AKH86451"/>
        <property type="gene ID" value="AA958_00070"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH87227">
        <property type="protein sequence ID" value="AKH87227"/>
        <property type="gene ID" value="AA958_34190"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_00070"/>
    <dbReference type="KEGG" id="strc:AA958_34190"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.15"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018958">
        <property type="entry name" value="Knr4/Smi1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037883">
        <property type="entry name" value="Knr4/Smi1-like_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00860">
        <property type="entry name" value="SMI1_KNR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160631">
        <property type="entry name" value="SSF160631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMI1_KNR4" evidence="1">
        <location>
            <begin position="4"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH87227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="147" mass="16346" checksum="EBE356AFD7CAD0F6" modified="2015-07-22" version="1">MQRPLTDQDVQEAEQLLDVTLPTSLLDLLRAQNGGQVTGTRNAFRTDKPTSWSEDHIPFDHLMGIGHRERAVSLLDSPYLVEEWDLPSPLVLLSGDGHYWIALDYRACGRHGEPSVAWFDADFSVELALAPDFGSFVEGLSSSSDFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A097H0Y0</accession>
    <name>A0A097H0Y0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">cnq739</name>
        <name evidence="2" type="ORF">AA958_30730</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="ChemBioChem" volume="15" first="2385" last="2392">
            <title>A Membrane-Bound Prenyltransferase Catalyzes the O-Prenylation of 1,6-Dihydroxyphenazine in the Marine Bacterium Streptomyces sp. CNQ-509.</title>
            <authorList>
                <person name="Zeyhle P."/>
                <person name="Bauer J.S."/>
                <person name="Steimle M."/>
                <person name="Leipoldt F."/>
                <person name="Rosch M."/>
                <person name="Kalinowski J."/>
                <person name="Gross H."/>
                <person name="Heide L."/>
            </authorList>
            <dbReference type="PubMed" id="25224759"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CNQ-509</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KJ451627">
        <property type="protein sequence ID" value="AIT42127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019092.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_30730"/>
    <dbReference type="EnsemblBacteria" id="AKH85864">
        <property type="protein sequence ID" value="AKH85864"/>
        <property type="gene ID" value="AA958_30730"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_30730"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6495"/>
    <dbReference type="OrthoDB" id="1337662at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006764">
        <property type="entry name" value="SAM_dep_MeTrfase_SAV2177_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04672">
        <property type="entry name" value="Methyltransf_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017393">
        <property type="entry name" value="MTase_SAV2177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIT42127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="258" mass="28676" checksum="0AD04545BAACBA6E" modified="2015-01-07" version="1">MPLPDARKPHPSRFWDYALGGRDNVHADRDLLEEAERIMPDLKVLTREQRLFVDRTVEYWVGEAGVRQILDIGGGMPTGIYDNVHEVAHRIAPDTRVVYVDKNPVAVAHMAALQADGEYTVALEGDVRDPDTILFDEVVRSTLDFTLPVGVLLSGILHFITDEEDPAAIVSRIHEAVVPGSFLSVNHISSDIDPRVPDVIEIFRRASDPLIDRDRAELERILAPWTPVDPGLVPVSRWRPAGEAQNACDAYGAVLRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MYU6</accession>
    <name>A0A0F7MYU6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_00655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH80921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014287.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_00655"/>
    <dbReference type="EnsemblBacteria" id="AKH80921">
        <property type="protein sequence ID" value="AKH80921"/>
        <property type="gene ID" value="AA958_00655"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_00655"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.151"/>
    <dbReference type="OrthoDB" id="1644255at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="13"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH80921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="141" mass="15360" checksum="14DB102008B34AB2" modified="2015-07-22" version="1">MLDEDARKQVALEYCRRINEGDVDGVLGLFADPLHVEDPVGDKTFIERAAYRAHIARLVSYGVHELPGAPVAGLDREHVALPITAELRPEGVPRGKFVRISLIAVMRIGANGLIRHMRVISGRTDMAVHDAAEAADAARFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MYW0</accession>
    <name>A0A0F7MYW0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH tetR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_00735</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH80936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014302.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH80936">
        <property type="protein sequence ID" value="AKH80936"/>
        <property type="gene ID" value="AA958_00735"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_00735"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.167"/>
    <dbReference type="OrthoDB" id="2089619at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041678">
        <property type="entry name" value="TetR_C_16"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17920">
        <property type="entry name" value="TetR_C_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="20"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH80936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="232" mass="24907" checksum="6DBDA38134477448" modified="2015-07-22" version="1">MARPHEPGGRPADEPPEAGQDRRELIRLAAVELFARHGYRGTTVRAIAERAGVDPALVMYHFGSKENVFSTVIRETMRAEELLPELPHLLDEVADTDSADDPAADGKCPGGPGSRLLRGFLTRWEDAATRPSLLVVFRSAMEHPEASQLFREVAGGELLLPLARRIPAPDPELRAVLVASLLVGLVTGRYVVPIEPLAGMELDTVVGLYGPYADDMLLGRLGGSPPPGLPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MZS8</accession>
    <name>A0A0F7MZS8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Sulfate adenylyltransferase</fullName>
            <ecNumber evidence="1">2.7.7.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_05975</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.7.4" evidence="1"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015178.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_05975"/>
    <dbReference type="EnsemblBacteria" id="AKH81825">
        <property type="protein sequence ID" value="AKH81825"/>
        <property type="gene ID" value="AA958_05975"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_05975"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1249"/>
    <dbReference type="OrthoDB" id="244339at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004781">
        <property type="term" value="F:sulfate adenylyltransferase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006790">
        <property type="term" value="P:sulfur compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04166">
        <property type="entry name" value="CysN_ATPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03695">
        <property type="entry name" value="CysN_NodQ_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04095">
        <property type="entry name" value="CysN_NoDQ_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041757">
        <property type="entry name" value="CysN_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044138">
        <property type="entry name" value="CysN_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044139">
        <property type="entry name" value="CysN_NoDQ_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011779">
        <property type="entry name" value="SO4_adenylTrfase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="SSF50465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02034">
        <property type="entry name" value="CysN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Tr-type G" evidence="7">
        <location>
            <begin position="18"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH81825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="451" mass="48227" checksum="FD51D6840CC607DC" modified="2015-07-22" version="1">MTVNPPAPATEPAALTEVSLLRFATAGSVDDGKSTLVGRLLHDSKSVLADQLEAVERASASRGQEAPDLALLTDGLRAEREQGITIDVAYRYFATPRRRFILADTPGHVQYTRNMVTGASTAELAVILVDARHGVVEQTRRHAAVAALLRVPHVVLAVNKMDLVGYAEDVFAAIAAEFTTYAKALGVPAVTTIPISALEGDNVVTPSAVMDWYAGPTVLEHLETVQIDHDPRGRVTRFPVQYVIRPQTAEHRDYRGYAGKIASGIFHVGQPVTVLPSGHTSSVAAIDVLGESVDAAWAPQSVTIRLADDIDISRGDMIAPTEQAPDATQDIQATVCHLHDTALTPGARVLLKHTTRTVKAIVKQIPDRLTLDDLSHHPSPGSLEVNDIGRVVLRTSEPLPMDAYGDCRRTGSFLLIDPADGSTLAAGMAGAAFAGADSEKRAELDDAEWDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0A7</accession>
    <name>A0A0F7N0A7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Threonine--tRNA ligase</fullName>
            <ecNumber evidence="10">6.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Threonyl-tRNA synthetase</fullName>
            <shortName evidence="10">ThrRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 13" type="primary">thrS</name>
        <name evidence="13" type="ORF">AA958_03370</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + H(+) + L-threonyl-tRNA(Thr)</text>
            <dbReference type="Rhea" id="RHEA:24624"/>
            <dbReference type="Rhea" id="RHEA-COMP:9670"/>
            <dbReference type="Rhea" id="RHEA-COMP:9704"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78534"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.3" evidence="10"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014740.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_03370"/>
    <dbReference type="EnsemblBacteria" id="AKH81381">
        <property type="protein sequence ID" value="AKH81381"/>
        <property type="gene ID" value="AA958_03370"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_03370"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.716"/>
    <dbReference type="OrthoDB" id="900765at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004829">
        <property type="term" value="F:threonine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006435">
        <property type="term" value="P:threonyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00771">
        <property type="entry name" value="ThrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00184">
        <property type="entry name" value="Thr_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002320">
        <property type="entry name" value="Thr-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033728">
        <property type="entry name" value="ThrRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451">
        <property type="entry name" value="PTHR11451"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01047">
        <property type="entry name" value="TRNASYNTHTHR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="SSF55186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00418">
        <property type="entry name" value="thrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 10 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 10" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="TGS" evidence="12">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="11">
        <location>
            <begin position="292"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="355"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="406"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="533"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AKH81381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="660" mass="73963" checksum="22324EB8A3CE43D0" modified="2015-07-22" version="1">MSDVRVIISRDAAEREERVVTTGTTAGDLFPGERTVIAARVAGALKDLAYVVADGDEVEPVEIDSPDGLDILRHSTAHVMAQAVQELFPEAKLGIGPPIKDGFYYDFDVPEPFHPDDLKRVEKKMQEIVKRGQRFSRRVTTDADAREELAAEPYKLELIGLKGNAADAAEGASAEVGAGELTIYDNLDAKTGELCWKDLCRGPHLPTTRLIPAFKLMRSAAAYWRGSEKNPQLQRIYGTAWPSRDELKAHLEFLAEAEKRDHRKLGTELDLFSIPEDIGSGLAVFHPKGGVVRRVMEDYSRRRHEESGYEFVYTPHATKGKLFEKSGHLDWYADGMYPPMQLDEGQDYYLKPMNCPMHNLIFDARGRSYRELPLRLFEFGTVYRYEKSGVVHGLTRARGFTQDDAHIYCTKEQMAGELDSLLTFVLNLLRDYGLEDFYLELSTKDPEKSIGSDEVWEEATEILRRAAEKQGLQLVMDPGGAAFYGPKISVQAKDAIGRTWQMSTIQVDFNLPERFDLEYTAADGSRQRPVMIHRALFGSIERFFAVLLEHYAGAFPAWLAPVQVVGIPIGDDHVPYLQEVAAKMRARGLRVEVDSSSDRMQKKIRNAQKAKVPYMLIAGDDDMAKGAVSFRYRSGEQNNGVPIDDAIDEVARAVAERAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0E8</accession>
    <name>A0A0F7N0E8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Molybdenum cofactor biosysynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_07515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015455.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_07515"/>
    <dbReference type="EnsemblBacteria" id="AKH82105">
        <property type="protein sequence ID" value="AKH82105"/>
        <property type="gene ID" value="AA958_07515"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_07515"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1575"/>
    <dbReference type="OrthoDB" id="1877633at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005302">
        <property type="entry name" value="MoCF_Sase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03473">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="SSF50800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51340">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MOSC" evidence="1">
        <location>
            <begin position="18"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="180" mass="18835" checksum="3A00C4B564654161" modified="2015-07-22" version="1">MNGTVTAVCSSGGYTFHKPAREAITLLAGLGVEGDAHAGVTVKHRSRVARDPSQPNLRQVHLVHEELFAEVAEAGFAVRPGELGENVTTRGVDLLGLPTGTLLHLGAEAVVEVTGLRNPCHQIDDFQSGLLKQVVGRDAAGKVVRKAGVMSVVLTGGVVRPGDPVVVVLPDAPHRPLEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0M7</accession>
    <name>A0A0F7N0M7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HATPase_c domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_00910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH80963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014329.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_00910"/>
    <dbReference type="EnsemblBacteria" id="AKH80963">
        <property type="protein sequence ID" value="AKH80963"/>
        <property type="gene ID" value="AA958_00910"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_00910"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.202"/>
    <dbReference type="OrthoDB" id="1832160at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HATPase_c" evidence="1">
        <location>
            <begin position="12"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH80963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="142" mass="15355" checksum="96CC75BBA1CB35E4" modified="2015-07-22" version="1">MADQQEASVTLPSEAASVTQARKYVTDILGKWGLPEGTDATDTVRLVVSELATNAVQHTRGQSPTFTVRMVLVRRQLRVGVSDSHPRRPRRLPAAVQQDNGRGMVIVRCLVAESGGRLSVTPTDDGGKTVWIALPWRPASVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0N8</accession>
    <name>A0A0F7N0N8_9ACTN</name>
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        <submittedName>
            <fullName evidence="1">ATP/GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_08110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_08110"/>
    <dbReference type="EnsemblBacteria" id="AKH82200">
        <property type="protein sequence ID" value="AKH82200"/>
        <property type="gene ID" value="AA958_08110"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_08110"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1709"/>
    <dbReference type="OrthoDB" id="1107373at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039480">
        <property type="entry name" value="C-C_Bond_Lyase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15617">
        <property type="entry name" value="C-C_Bond_Lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH82200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="394" mass="42903" checksum="260DCEC89F2E34CE" modified="2015-07-22" version="1">MRHFGHVSPDVRAGLFHREPAEFTAEAPPAELAMALGATLYSPATRSQLARDIRVQAARGVVSMVLCLEDSIADDEVPEAEANVVRQLRELERQGAGSALPLLFVRTREAGQIPDLVARLGPAARLLSGFVLPKFTAVQGVAFLEAVIKAEQVLPPGGRRLYAMPVVESPEVLHLESRAAALRGIARVLEQYRERVLAVRLGVTDFCAAYGLRRSPDMTAYDVQLVAAAIGDVVNVFGRADGSGFTVTGPVWEYFRQQERLFKPQLRSSPFAAGRAEELRAALIEHDMDGLLREISLDRANGLQGKTCIHPSHVAPVHALSVVSHEEYVDATDIVRKSGAGGGVMRSAYTNKMNEAKPHRAWAERTLRRARMFGVAREDTTFVELLAAAGRGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0P8</accession>
    <name>A0A0F7N0P8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AA958_00675</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNQ-509</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH80924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_00675"/>
    <dbReference type="EnsemblBacteria" id="AKH80924">
        <property type="protein sequence ID" value="AKH80924"/>
        <property type="gene ID" value="AA958_00675"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_00675"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.155"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033068">
        <property type="term" value="P:macrolide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015083">
        <property type="entry name" value="Polyketide_synth_docking"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08990">
        <property type="entry name" value="Docking"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="2 8" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="10">
        <location>
            <begin position="2017"/>
            <end position="2092"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="10">
        <location>
            <begin position="3768"/>
            <end position="3843"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="10">
        <location>
            <begin position="5519"/>
            <end position="5594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="4857"/>
            <end position="4896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="4873"/>
            <end position="4891"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="8">
        <location>
            <position position="2052"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="8">
        <location>
            <position position="3803"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="8">
        <location>
            <position position="5554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AKH80924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="5676" mass="599696" checksum="5806C4C050B7AE46" modified="2015-07-22" version="1">[encoded data, 5676 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N1B1</accession>
    <name>A0A0F7N1B1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tat pathway signal sequence domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_02185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014538.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_02185"/>
    <dbReference type="EnsemblBacteria" id="AKH81174">
        <property type="protein sequence ID" value="AKH81174"/>
        <property type="gene ID" value="AA958_02185"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_02185"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.470"/>
    <dbReference type="OrthoDB" id="1278405at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50939">
        <property type="entry name" value="SSF50939"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519062" evidence="1">
        <location>
            <begin position="30"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="488" mass="52750" checksum="755E9D26C9FCB72A" modified="2015-07-22" version="1">MRLLSRTFVKPALLTAALLLTATALPVAAADAGPAAAPGPPPAPGPSLTRIADTELDPEAVYFVSFDGLVNNSSFTKNGILTHKRHQYAAWYTADRSAVVARRALGDREWETVTLDHRLKYDDSHNVISLGLSAADGRLHVNMDSHADGFFYLKSAPGLMNRPEAHDWTADAFGPVQTSLDALPLTDRFTYPQFVATPAGGLLLSYRDGVSGNGRNALAAYDGKRWRALGQWSGSTGTYTTEHGSSSARNMYLHGIDYGPDGTLHAFYTWREQNTAVMCAPGGLSNHDTGYVRSTDDGRTWTNAAGEAVGTTGGPDLVAFDDPGTVADPLNADHALMNQEHQATDSAGRPHALISYVPGRFGQCSTDYVADRKANARTFHLHRDDAGRWHKTELPVPLASSQRSKLAFDRYDNAYAVLPYGRIAAASAASGWTDWKVLFDGADLDAFGEVNLDETRLTQDGVLSFMYQQKSTGTTPSPLRTVDFALPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-12-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N1F2</accession>
    <name>A0A0F7N1F2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Dodecin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_02680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014621.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH81258">
        <property type="protein sequence ID" value="AKH81258"/>
        <property type="gene ID" value="AA958_02680"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_02680"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.572"/>
    <dbReference type="OrthoDB" id="2025589at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009923">
        <property type="entry name" value="Dodecin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025543">
        <property type="entry name" value="Dodecin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036694">
        <property type="entry name" value="Dodecin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39324">
        <property type="entry name" value="PTHR39324"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07311">
        <property type="entry name" value="Dodecin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89807">
        <property type="entry name" value="SSF89807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH81258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="73" mass="8014" checksum="62534D4AFF4068F6" modified="2015-07-22" version="1">MSDHTYRLTEIVGSSHTGVDDAVRNGVARASQTLRNLDWFEVTQVRGQLENGAVAHWQVCLKVGFRLEDAGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N1L6</accession>
    <name>A0A0F7N1L6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 12">Aspartate-semialdehyde dehydrogenase</fullName>
            <shortName evidence="12">ASA dehydrogenase</shortName>
            <shortName evidence="12">ASADH</shortName>
            <ecNumber evidence="7 12">1.2.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Aspartate-beta-semialdehyde dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">asd</name>
        <name evidence="14" type="ORF">AA958_09745</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>L-aspartate 4-semialdehyde + NADP(+) + phosphate = 4-phospho-L-aspartate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:24284"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.2.1.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 2/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 12">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 12">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 12">Belongs to the aspartate-semialdehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.11" evidence="7 12"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015808.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_09745"/>
    <dbReference type="EnsemblBacteria" id="AKH82465">
        <property type="protein sequence ID" value="AKH82465"/>
        <property type="gene ID" value="AA958_09745"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_09745"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2054"/>
    <dbReference type="OrthoDB" id="1799040at2"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00016"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00463"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00464"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004073">
        <property type="term" value="F:aspartate-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071266">
        <property type="term" value="P:'de novo' L-methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02121">
        <property type="entry name" value="ASADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000319">
        <property type="entry name" value="Asp-semialdehyde_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012080">
        <property type="entry name" value="Asp_semialdehyde_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005986">
        <property type="entry name" value="Asp_semialdehyde_DH_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012280">
        <property type="entry name" value="Semialdhyde_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02774">
        <property type="entry name" value="Semialdhyde_dhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01296">
        <property type="entry name" value="asd_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01103">
        <property type="entry name" value="ASD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 12" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="11 12" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="12" id="KW-0521">NADP</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="Semialdhyde_dh" evidence="13">
        <location>
            <begin position="2"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="12">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="256"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="9"/>
            <end position="12"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="37"/>
            <end position="38"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="160"/>
            <end position="161"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="323"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AKH82465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="345" mass="35913" checksum="7CB68E2A7D1C3204" modified="2015-07-22" version="1">MKIGIVGATGQVGGVMRDILAERAFPVDQLRLFASARSAGRTLPWRDAPGGTVTVEDAGTADYSGLDIVLFSAGGATSRAIAEKVAAQGPVVIDNSSAWRRDPAVPLVVSEVNPHAVADRPKGIIANPNCTTMAAMPVLKPLHREAGLVSMVVATYQAVSGSGLAGVDELYEQVRAAGEDAPKLTRDGAAVAFPEPAKYVAPIAYNVLPMAGSLVDDGLDETDEEQKLRHESRKILEIPELKVSGTCVRVPVFTGHSLQVNARFAEPLSPARAAEVLAGAEGVALADVPTPLGAAGRDVSYVGRIRRDETAENGLALFLSGDNLRKGAALNAVQIAELVAAEARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N1P2</accession>
    <name>A0A0F7N1P2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_02920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH81299">
        <property type="protein sequence ID" value="AKH81299"/>
        <property type="gene ID" value="AA958_02920"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_02920"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.624"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="113" mass="12058" checksum="03576CE5167EA096" modified="2015-07-22" version="1">MPPRLAHRARRGRGGALPLDVRGAPRGRPLPPSPPVLRGPRGSTARAARPVCAGQHRPRPGPSTAPAGVPAKRPVRPGSWTRSVAPASSDLAHKERGLVCYSRVGHTRRVVWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N1S0</accession>
    <name>A0A0F7N1S0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein-export membrane protein SecF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">secF</name>
        <name evidence="11" type="ORF">AA958_03275</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the SecD/SecF family. SecF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014722.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_03275"/>
    <dbReference type="EnsemblBacteria" id="AKH81363">
        <property type="protein sequence ID" value="AKH81363"/>
        <property type="gene ID" value="AA958_03275"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_03275"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.697"/>
    <dbReference type="OrthoDB" id="410730at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015450">
        <property type="term" value="F:protein-transporting ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043952">
        <property type="term" value="P:protein transport by the Sec complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01464_B">
        <property type="entry name" value="SecF_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022813">
        <property type="entry name" value="SecD/SecF_arch_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022645">
        <property type="entry name" value="SecD/SecF_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005665">
        <property type="entry name" value="SecF_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30081">
        <property type="entry name" value="PTHR30081"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02355">
        <property type="entry name" value="SecD_SecF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01755">
        <property type="entry name" value="SECFTRNLCASE"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00916">
        <property type="entry name" value="2A0604s01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00966">
        <property type="entry name" value="3a0501s07"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="140"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="164"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="246"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="275"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="310"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="310"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AKH81363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="400" mass="42440" checksum="3095C508AD46F832" modified="2015-07-22" version="1">MSRLGTLGARLYRGEAGYDFVAKRFLWYGVSVLITIIAIAGFLIRGLNMGIEFEGGAVFTTPKTETSVSQAQEVAEEASGHQAIVQELGSGKLRIQVSSIETQQSDKVKTALADELNVSAEDINDQLVGPSWGEQIAKKAWQGLAIFMVLVVIYLAIAFEWRMALAALVALIHDLTITVGVYTIVGFEVTPGTVIGLLTILGYSLYDTVVVFDGLKESTKDITKQTGFTYREAANRSLNGTLVRSINTSVVALLPVAGLLFIGGGVLGGGMLNDIALSLFVGLAAGAYSSIFIATPLVVDFKERDPAIQSHNKRVAARRASDARSAARGEKGTAGRADGPDAAAVEDDEPEDDPRAPQPAGQGVVGPPRAEGRRQQPVSRQRGRGRPSGSRGGRSGGKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N1T8</accession>
    <name>A0A0F7N1T8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_03505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014761.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_03505"/>
    <dbReference type="EnsemblBacteria" id="AKH81403">
        <property type="protein sequence ID" value="AKH81403"/>
        <property type="gene ID" value="AA958_03505"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_03505"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.740"/>
    <dbReference type="OrthoDB" id="1538300at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="15"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="201" mass="22350" checksum="8E9AB825CB4F3705" modified="2015-07-22" version="1">MSSTFPDVSLSTDRLVLRPFDEEDVPALTEMMNDEAVTAWTQAPHPYTGDDAYDWVTRVAPAERTGGRGIVFAVSEFLTQRLVGNVHLRRTDWRTLATEARFVVAPWARGEGYAAESVLAVARWLFDVQKFERLELRTAADNTAAQQVAQKLGGISEGVLRNAWIARTRTEDGGWTDIRTDLIVWSLLPEDLDPDGGSSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N289</accession>
    <name>A0A0F7N289_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_07610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015471.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_07610"/>
    <dbReference type="EnsemblBacteria" id="AKH82121">
        <property type="protein sequence ID" value="AKH82121"/>
        <property type="gene ID" value="AA958_07610"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_07610"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1597"/>
    <dbReference type="OrthoDB" id="1907687at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="21"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="156" mass="16610" checksum="6D8983B3FEBF9CF3" modified="2015-07-22" version="1">MTSNEEVVREAYRLAEGSVLDGEGFRALFTEDGTFNDVPNALTFLADQIPQALAGLASAFPDIHRELLAVHAIGDVVAVELRIQGTHLGGFPTPIGEIGPTGHRIDVPTADLWYLREGKIETFNCYNAANVWLAQLGASPDFESAIEAAKTASAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2R2</accession>
    <name>A0A0F7N2R2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-Ala-His dipeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_01935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014496.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_01935"/>
    <dbReference type="EnsemblBacteria" id="AKH81132">
        <property type="protein sequence ID" value="AKH81132"/>
        <property type="gene ID" value="AA958_01935"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_01935"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.418"/>
    <dbReference type="OrthoDB" id="275025at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="1">
        <location>
            <begin position="205"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="456" mass="48169" checksum="4F96BD676927BE79" modified="2015-07-22" version="1">MDTDRLAGTVAGLLPRARTELAELVSFRSVALIDPERFPATESDAAARWITDALTAEGFTDVRLLDTPDGTRSVYGYLPGPAGAPTVLLYAHYDVQPPLDESAWLSPPFELTERDGRWYGRGAADCKGGVLMHLTALRALRENGGVPVSVKIIVEGSEEQGTGGLQQYAEQHPELLAADTIVIGDVGNFRVGLPTVTATLRGMTMLRVQVDALAGNLHSGQFGGAAPDALAALIRILDSLRGPDGSTTVDGLAPGSRWDGLAYPEDTFRRDAKVLDGVELIGTGSVADRIWASPAVTVIGMDVPSVAGATPSVQATAAALVSLRLPPGHGSAEATERLTAHFEAHAPWGVKVTTESYGSGEPFRADVTSPAYRAMAEALRAAYPGEEMQVAGQGGTIPLCNTLAELYPRAEILLIGLSEPEAQIHAVNESVSPEELERLSFAEALFLHRYASGRAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2R5</accession>
    <name>A0A0F7N2R5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_08810</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015658.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_08810"/>
    <dbReference type="EnsemblBacteria" id="AKH82311">
        <property type="protein sequence ID" value="AKH82311"/>
        <property type="gene ID" value="AA958_08810"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_08810"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1856"/>
    <dbReference type="OrthoDB" id="1619224at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="170"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="226"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="278"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="87"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH82311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="312" mass="34650" checksum="E617DB20FD1BB46E" modified="2015-07-22" version="1">MISSLKQSYSRHWYAYAMVAPVVAVLGVLVAYPLGRGVYLSLTDATSDNVGRTIGVNEIPDSFSFVGFDHYVEILTGSAADTFWKQFAWTLFWTAACVALHYGIGLGLAVLLNRRMRGRTLYRLALILPWAVPTFVTVFSWRMILADGGVLNSVFASVGMPEPAWLSEPFWQRAAAIVVNTWCGVPFMMVSLLGGLQSIPNELYEAAETDGATPWQRFRYVTLPGLRAVSSTVIMLGVIWTFNQFIVIFLLFGSTAPDTEILVTWAYRLGFGQTPRDYAGSAAYGVIILSMLVVLVSVYRRWLNRNEEAAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2S6</accession>
    <name>A0A0F7N2S6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">UDP-N-acetyl-D-glucosamine dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_08870</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_08870"/>
    <dbReference type="EnsemblBacteria" id="AKH82321">
        <property type="protein sequence ID" value="AKH82321"/>
        <property type="gene ID" value="AA958_08870"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_08870"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1868"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017476">
        <property type="entry name" value="UDP-Glc/GDP-Man"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014027">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036220">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014026">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001732">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028359">
        <property type="entry name" value="UDP_ManNAc/GlcNAc_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00984">
        <property type="entry name" value="UDPG_MGDP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03720">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03721">
        <property type="entry name" value="UDPG_MGDP_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500136">
        <property type="entry name" value="UDP_ManNAc_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000124">
        <property type="entry name" value="UDPglc_GDPman_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00984">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52413">
        <property type="entry name" value="SSF52413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03026">
        <property type="entry name" value="NDP-sugDHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDPG_MGDP_dh_C" evidence="4">
        <location>
            <begin position="319"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH82321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="420" mass="45246" checksum="F6CBA0A099D9F23D" modified="2015-07-22" version="1">MGEKVVVMGQGYVGLPLAVAAAERGYEVVGFEVDEDRVKKLAVGESYVGDVDSAHLAALLDSGAYRPTMEPDDLAGFDLAVITVPTPMRDGLPDLSYIEAAGTTLARWLRPGAAVSLESTSYPGTTGDVLAPLLERLSGLAAGTDFHLGYSPERIDPGNTRWTFTTTPKVVAGVDERSRRRLADFYGSIVDTVVPAPTVRVAEMAKVLENTFRHVNIALVNELAMHAEALGVDVWDALDIAATKPFGFMRFTPGPGVGGHCLPVDPLYLSWKVEQDLSRPFRMVALADELNTQMPEYVVRRVTRGLGRRGQTLHGARVLMLGLAYKPNTGDVRESPAVRLAEQLLAEGAQVRVADPVVSEDPGVAGLVRVELSDEEVQAAHVVLVATDHDAFDYAHLVATAGYIFDCRHRVPAADHVESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N333</accession>
    <name>A0A0F7N333_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ArsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_13370</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016386.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_13370"/>
    <dbReference type="EnsemblBacteria" id="AKH83055">
        <property type="protein sequence ID" value="AKH83055"/>
        <property type="gene ID" value="AA958_13370"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_13370"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2812"/>
    <dbReference type="OrthoDB" id="1629121at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014036">
        <property type="entry name" value="DeoR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018356">
        <property type="entry name" value="Tscrpt_reg_HTH_DeoR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00455">
        <property type="entry name" value="DeoRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08220">
        <property type="entry name" value="HTH_DeoR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00037">
        <property type="entry name" value="HTHLACR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00420">
        <property type="entry name" value="HTH_DEOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00894">
        <property type="entry name" value="HTH_DEOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="4">
        <location>
            <begin position="3"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH83055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="252" mass="26883" checksum="35E3BFD0210530FA" modified="2015-07-22" version="1">MLRETRHEKLLSILGDEGVLPVRDIAKRLGVSEATARRDLTELGRAGRLTRVYGGAVAARADDERPFAEVADDDPGGREAVAARAAELIEDGDVVLLDIGTTTLALAQRLRGRPVTIVTSNLAVYEELRDDHAVTLILLGGEVRRNYRSVVGVLTESNLRELYVGRLFLGASGILPDGSVLDSTHVEVPVKRAMIKASRQVVLLASAGKFPGDSGLVRICGPEDVHMLITNTSSDPVTLAAFGEAGVEVVTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3I3</accession>
    <name>A0A0F7N3I3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SAM-dependent methlyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_14460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016551.1">
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_14460"/>
    <dbReference type="EnsemblBacteria" id="AKH83235">
        <property type="protein sequence ID" value="AKH83235"/>
        <property type="gene ID" value="AA958_14460"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_14460"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3043"/>
    <dbReference type="OrthoDB" id="1518440at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="94"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="284" mass="31510" checksum="F717BB59BBD73646" modified="2015-07-22" version="1">MAAAADTNVLTSPYQHSIADYWNRERDPVNLKLGDVSGTYHHHYGIGEVDQSVLGGPEETRGERIIAEMHRLETAQATLLLDHLGEPDRGARLLDAGSGRGGTSFMAHERFGCRVDGISISQSQVSFANDQVQRRGLGSAVRFHLKNMLDTGFETGAFRGIWNNESTMYVELAQLFKEHARLLARGGRYVTITGCYNDAYGLPSRAVSQINAHYICNVHPRSTYFKELVANRLVPAQVIDLTEATIPYWELRAKSSVATGIEEVFLTAYRSGSFQYLLIAADRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3M3</accession>
    <name>A0A0F7N3M3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_06710</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015305.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_06710"/>
    <dbReference type="EnsemblBacteria" id="AKH81953">
        <property type="protein sequence ID" value="AKH81953"/>
        <property type="gene ID" value="AA958_06710"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_06710"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1402"/>
    <dbReference type="OrthoDB" id="1694750at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012354">
        <property type="entry name" value="Esterase_lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017388">
        <property type="entry name" value="Esterase_lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydrolase_4" evidence="4">
        <location>
            <begin position="19"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="1">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="1">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR017388-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR017388-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH81953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="265" mass="28453" checksum="9562B4867B9F2302" modified="2015-07-22" version="1">MPVLSGAEPFRQPGGGTGVLVCHGFTGSPQSVRPWAEHLAARGLTVSMPLLPGHGTRWQDLQVTRWQDWYATVDRELRELSGECARVFLCGLSMGGTLMLRLAALHGDAVAGVVVVNPLNKLHGVLPKALPAARFLVRSSPGVINDIAKEGAAETGYDRVPLHAAHSLRQLLARVDGELPQVTQPLLVLHSRVDHVVSPVDSARILGRVSSLDVTETVLEDSYHVATLDHDAERIFSATDDFIDRLTPPADGSEQRKGARARGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3Q0</accession>
    <name>A0A0F7N3Q0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AsnC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_06795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015320.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_06795"/>
    <dbReference type="EnsemblBacteria" id="AKH81968">
        <property type="protein sequence ID" value="AKH81968"/>
        <property type="gene ID" value="AA958_06795"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_06795"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1421"/>
    <dbReference type="OrthoDB" id="1855714at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AsnC_trans_reg" evidence="1">
        <location>
            <begin position="6"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="93" mass="9938" checksum="8796475EDC2CEAC4" modified="2015-07-22" version="1">MITAIVLINTDVDRIPEIAESIAAIDGVSEVYSVTGAHDLIAIVRVARHDDLADVIPGRISKVPGVAGTETHISFRTYSQHDLEAAFAIGLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3Q1</accession>
    <name>A0A0F7N3Q1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polyketide cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_14850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016600.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_14850"/>
    <dbReference type="EnsemblBacteria" id="AKH83285">
        <property type="protein sequence ID" value="AKH83285"/>
        <property type="gene ID" value="AA958_14850"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_14850"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3130"/>
    <dbReference type="OrthoDB" id="1691158at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005031">
        <property type="entry name" value="COQ10_START"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03364">
        <property type="entry name" value="Polyketide_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Polyketide_cyc" evidence="1">
        <location>
            <begin position="11"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="158" mass="18096" checksum="EC6DF197E12F1782" modified="2015-07-22" version="1">MGARTEHAIVIDAPVDLVWTMTNDVESWPDLFAGYAETEILRATDDGIDFRIKTHPDANGRVWEWVSHRVPDRESLTVEAHRIETGPFVYMKLHWSYRVTGEGTELRWVQEFDMKEGAPYDNAQMTAHLNEMSEINMGRIKEIVETAHRSRQEGAPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3W9</accession>
    <name>A0A0F7N3W9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carboxymuconolactone decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_04385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014907.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_04385"/>
    <dbReference type="EnsemblBacteria" id="AKH81552">
        <property type="protein sequence ID" value="AKH81552"/>
        <property type="gene ID" value="AA958_04385"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_04385"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.923"/>
    <dbReference type="OrthoDB" id="1893149at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMD" evidence="1">
        <location>
            <begin position="41"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="189" mass="20127" checksum="C9A27C6FA6B0993F" modified="2015-07-22" version="1">MTLRVPRAELPGEMREAMVKQFGALPEPVEVLFNHPDVAVDNLEFAAKAASWRAVDASLKSFAHMAVAALVGCSWCLDVGYFQARNEDLDPAKASQVPRWRDSDVFSPLEREVMAYAEAMSVTPTAVTDAQAASLLAQLGAAGLVELTAFVGFVNLSTRANTAHGVTSQGFSESCEIPLAGRTEAAGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N420</accession>
    <name>A0A0F7N420_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_07570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015464.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_07570"/>
    <dbReference type="EnsemblBacteria" id="AKH82114">
        <property type="protein sequence ID" value="AKH82114"/>
        <property type="gene ID" value="AA958_07570"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_07570"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1586"/>
    <dbReference type="OrthoDB" id="453710at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021228">
        <property type="entry name" value="BrxD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10923">
        <property type="entry name" value="DUF2791"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH82114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="440" mass="47513" checksum="923C938CAA3BD8D5" modified="2015-07-22" version="1">MVPVNDVRGQVSTVRRRSVVDALRRGAVPEQGLDLLATGLDRFAPAVDEELETVAGGGSVFKAVRGEYGSGKTFFTRWLAERGKARGFAVCEIQISENETPLHKLETVYRRLIERLATSAFPPSALQQVVDGWFYALEEDALADGVGEDALADAVDRLMSARLAEVSRHAPAFAAALRGYRQALEAGDDTSAAAVLAWLGGQPHVSAAARKTAGVRGDLDHFGALGFLQGLLTVLRDTGHAGLVVVLDEVETLQRVRSDARDKALNALRQLIDEVHSGRFPGLYLVITGTPAFYDGPQGVQRLAPLAQRLATDFTTDPRFDNPRAVQIRLPGFTGERLVQLGLKVRDLYAAGAGDPVRIREVADEAYIDDLAKAVGGRLGGKVGVAPRIFLKKLVGDVLDRIDQFEEFDPRLHYQLTLSGGELTDTERNAAAADDIGLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N474</accession>
    <name>A0A0F7N474_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein tyrosine phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_15895</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the low molecular weight phosphotyrosine protein phosphatase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016757.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_15895"/>
    <dbReference type="EnsemblBacteria" id="AKH83445">
        <property type="protein sequence ID" value="AKH83445"/>
        <property type="gene ID" value="AA958_15895"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_15895"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3349"/>
    <dbReference type="OrthoDB" id="2062716at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006470">
        <property type="term" value="P:protein dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023485">
        <property type="entry name" value="Ptyr_pPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036196">
        <property type="entry name" value="Ptyr_pPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017867">
        <property type="entry name" value="Tyr_phospatase_low_mol_wt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01451">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00719">
        <property type="entry name" value="LMWPTPASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00226">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52788">
        <property type="entry name" value="SSF52788"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LMWPc" evidence="3">
        <location>
            <begin position="15"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH83445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="173" mass="18889" checksum="F8F75DC014205A1A" modified="2015-07-22" version="1">MERMRTSERPLPAPFRVCFVCTGNICRSPMAEAVFRARVAEAGLDGEIEVDSAGTDGWHIGEAADPRAAAVLTGHGYELAHTARQFTPDWFAERDLVLGLDGGHVRRLLKIAPTPVDAEKVRLLLSFAPDLDLTDVEDPYYGGTRGFEEALDLIETAAEGLLQAVRDELTARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N495</accession>
    <name>A0A0F7N495_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_16020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016777.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_16020"/>
    <dbReference type="EnsemblBacteria" id="AKH83465">
        <property type="protein sequence ID" value="AKH83465"/>
        <property type="gene ID" value="AA958_16020"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_16020"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3375"/>
    <dbReference type="OrthoDB" id="1135906at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="32"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="589" mass="64041" checksum="45085A73532EC589" modified="2015-07-22" version="1">MSEWGGVAVRERWVRTGGVELCVAELGDAGQPTVVLLHGYPDSKEVWSQVASRLAERCHVVLYDVRGHGRSTAPKPLKGGFTLEKLTDDFTAVLDAVSPDRPVHLVGHDWGSVQGWEFTTVERTEGRIASFTSLSGPSLDHFGHWINGRLRRPTPRRAGQLLGQTAKSWYVYLLHTPVLPELAWRGPLGARWPAILRRLEKVPGDGYPTASLGDDAAHGAWLYRDNVRARLRRPRADAYAHAPVQLITPAGDAFLSPSLYDDLDRWVPQLLRRTIDARHWVPRTRPDQLAAWIGEFVLAHEDGTPAAEIVPDGPYADRFGGRLVLITGAGSGIGRATAFAFAEAGARIVAADTDAEGAATTAELCRMIGAAEAWPEAVDVADEEAMEKFAERVAAAYGVVDVLVNNAGIGLSGPFLDTSTADWRRVLDVNLWGVIHGCRLFGRQMAERGQGGHIVNTASAAAYAPSRTLPAYATSKAAVLMLSECLRAELSGQGIGVSAVCPGFVHTDITVTTRFAGVSEEEERRRRKSAHRWYGKRNYPAEKVADAVLRAVARNQAVVPVTPEARGSRLLARFAPRALRAIARVEPEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4B0</accession>
    <name>A0A0F7N4B0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LuxR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_05190</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015047.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH81692">
        <property type="protein sequence ID" value="AKH81692"/>
        <property type="gene ID" value="AA958_05190"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_05190"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1090"/>
    <dbReference type="OrthoDB" id="1687028at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="3"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="150"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH81692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="229" mass="24427" checksum="4EFF68FBBE5C823F" modified="2015-07-22" version="1">MIRVLLVDDQALIRGGFRALLDAEDDIEVVGEAADGAEGVRLAARHRPDVALVDVQMPVLDGIEATRRIAADPDLAGVHVVILTNYGVDEYVWGALRAGAAGFLVKDMEPEDLLHGVRVAARGDALLSPALTRKLIQEYVSRPAGGVPDTADALRELTRREREVVTLVGGGLSNEEIAARLHISPITAKTHVSRSMTKLGARDRAQLVVLAYETGLVTPRGPVAGRPAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4E0</accession>
    <name>A0A0F7N4E0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_16355</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016825.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_16355"/>
    <dbReference type="EnsemblBacteria" id="AKH83520">
        <property type="protein sequence ID" value="AKH83520"/>
        <property type="gene ID" value="AA958_16355"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_16355"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3444"/>
    <dbReference type="OrthoDB" id="1835483at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006470">
        <property type="term" value="P:protein dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PTHR13832"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="18"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="440"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH83520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="505" mass="54688" checksum="3A6A63818DF235EA" modified="2015-07-22" version="1">MRMYPEPTGEVRMSLSLRFAAGSHEGMIRDHNEDSGYAGPRLLAIADGMGGQAAGEVASSEVISVMVALDEDVPGSDLLTALGTTVEHANDRLRRMVEEDPRLEGMGTTLTALLWTGQRLGLVHVGDSRAYLLRDGALTQITKDHTWVQRLVDENRITEEEATTHPQRSLLMRALGSGDQVEPDLSIREVRAGDRYLVCSDGLSSVVSHETMENTLAGYAGPQETVQELIELALRGGGPDNITVIIADVLDAADDDTMAGRLNDAPLVVGAVAENQHQIDTAGMQTPAARAAGLGRPTPPQAGGFGPAGDGGDPYGLSYNDEDFVKAPPRFKWLKRGLLIAVVLGGLGFGGYKAYDWTQSQYYVGMKDDHVAVYQGIDQKLAWMSLSSVHQDHPDIELKYLPTYQQKRVEDNIAEESLGDAQAKVADLQEQADVCRTVAEAEAADSRAREEERRQQEQEKQNPDKQGDAGDKAGDRAGDEKPESPAPGASFTEEEQKLARQCPNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4F9</accession>
    <name>A0A0F7N4F9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADPH:quinone oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_16485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016845.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_16485"/>
    <dbReference type="EnsemblBacteria" id="AKH83540">
        <property type="protein sequence ID" value="AKH83540"/>
        <property type="gene ID" value="AA958_16485"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_16485"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3469"/>
    <dbReference type="OrthoDB" id="1027479at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05276">
        <property type="entry name" value="p53_inducible_oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014189">
        <property type="entry name" value="Quinone_OxRdtase_PIG3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02824">
        <property type="entry name" value="quinone_pig3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="10"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="325" mass="33251" checksum="AF8651D4B9A2081A" modified="2015-07-22" version="1">MHAITISEPGGPDSLVWAEVPDPVPAEGEVLIEVAAAGVNRADVLQRQGFYEPPAGASPYPGLECAGRIAALGAGVAGWQVGDEVCALLAGGGYAELVAVPAGQLLPVPRGHDAVTAAALPEVACTVWSNVFMIAHLRPGETLLVHGGGSGIGTMAVQLAKAVGARVAVTAGSVEKLEYCRELGADVLINYREQDFVKEVRAATGGAGADVILDIVGAAYLAQNVKALAVNGRIAVIGLQGGAKGELNLGALLAKRGAITATSLRGRPPGEKAAIVAAVREHVWPLVEADRVRPIVDRTLPVQQAGEAHRVMESSAHVGKLLLTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-08-12" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4Q7</accession>
    <name>A0A0F7N4Q7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_09220</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015724.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH82378">
        <property type="protein sequence ID" value="AKH82378"/>
        <property type="gene ID" value="AA958_09220"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_09220"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1945"/>
    <dbReference type="OrthoDB" id="1875458at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH82378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="230" mass="25321" checksum="E6D4A00CAC5C064C" modified="2015-07-22" version="1">MGGQIQREIMQLILDRGLRPGAVLPTETELMDDLGVSRNSVREALKALQALDIVEIRHGYGTYVGEASLTPLADGLTFRTLVQLGGDDAHALTEILQVREILEEGLISRVVESIPEADLDALDTIVARMETRAGQGEVFPEEDREFHEVLYRSIGNTLVPQLLGAFWNVFHRVAGARGWADDPSPLGTARRHKEIVAALRARDREHVRAAMTTHFRGIEARAGKAMRGVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4Z7</accession>
    <name>A0A0F7N4Z7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Succinate dehydrogenase</fullName>
            <ecNumber evidence="7">1.3.5.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">sdhA</name>
        <name evidence="7" type="ORF">AA958_06235</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.3.5.1" evidence="7"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015225.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_06235"/>
    <dbReference type="EnsemblBacteria" id="AKH81872">
        <property type="protein sequence ID" value="AKH81872"/>
        <property type="gene ID" value="AA958_06235"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_06235"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1304"/>
    <dbReference type="OrthoDB" id="153138at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033765">
        <property type="term" value="F:steroid dehydrogenase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008177">
        <property type="term" value="F:succinate dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037099">
        <property type="entry name" value="Fum_R/Succ_DH_flav-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015939">
        <property type="entry name" value="Fum_Rdtase/Succ_DH_flav-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030664">
        <property type="entry name" value="SdhA/FrdA/AprA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011280">
        <property type="entry name" value="Succ_DH/Fum_Rdt_flav_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632">
        <property type="entry name" value="PTHR11632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632:SF53">
        <property type="entry name" value="PTHR11632:SF53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02910">
        <property type="entry name" value="Succ_DH_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46977">
        <property type="entry name" value="SSF46977"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="SSF56425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01811">
        <property type="entry name" value="sdhA_Bsu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="5">
        <location>
            <begin position="48"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="Succ_DH_flav_C" evidence="6">
        <location>
            <begin position="514"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH81872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="649" mass="71983" checksum="6784C2FF9F8547C5" modified="2015-07-22" version="1">MSPAYTQYTEGDPVADTAAPPGDIAERWDRRRFTARLVNPANRRRYRVIVVGTGLAGGAAGATLAEQGYQVVQFCYQDSPRRAHSIAAQGGINAAKNYRNDGDSVHRLFYDTVKGGDFRARESNVRRLAQVSVEIIDQCVAQGVPFAREYGGLLDTRSFGGVQVSRTFYARGQTGQQLLLGAYQALSRQIDAGNVEMHPRTEMLDLIVVDGRARGIVARDLVTGRIETHLADAVVLATGGYGNVFYLSTNAKNSNATAIWRAHRRGAYFANPCFTQIHPTCIPRSGDHQSKLTLMSESLRNDGRIWVPKAHGDTRPPNAIPEHERDYYLERLYPSFGNLVPRDIASRAAKNVCDEGRGVGPGGQGVYLDFADAIRRLGRAAVEERYGNLFEMYERITAEDPYQVPMRIYPAIHYTMGGLWVDYDLQTTVPGLFAIGEANFSDHGANRLGASALMQGLADGYFILPATIGDFLARHRPEQVSPDHPAVTEAVADTEDRLHLLLAVDGDRTPDSFHRELGELLWDECGMARTEPGLRKALERIPALREEFWRRIKVPGTGTELNQSLEKANRIADYLELAELMCLDALHRAESCGGHFREESQTPDGEAARDDEQFSYAAAWEFTATGTAPVLHREDLAFEYVIPTQRSYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N525</accession>
    <name>A0A0F7N525_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pseudouridine synthase</fullName>
            <ecNumber evidence="3">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_06475</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Responsible for synthesis of pseudouridine from uracil.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a uridine in RNA = a pseudouridine in RNA</text>
            <dbReference type="Rhea" id="RHEA:48348"/>
            <dbReference type="Rhea" id="RHEA-COMP:12068"/>
            <dbReference type="Rhea" id="RHEA-COMP:12069"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pseudouridine synthase RluA family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="3"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015265.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_06475"/>
    <dbReference type="EnsemblBacteria" id="AKH81912">
        <property type="protein sequence ID" value="AKH81912"/>
        <property type="gene ID" value="AA958_06475"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_06475"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1352"/>
    <dbReference type="OrthoDB" id="1714699at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120159">
        <property type="term" value="F:rRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd02869">
        <property type="entry name" value="PseudoU_synth_RluA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006225">
        <property type="entry name" value="PsdUridine_synth_RluC/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00005">
        <property type="entry name" value="rluA_subfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S4" evidence="5">
        <location>
            <begin position="19"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="PseudoU_synth_2" evidence="4">
        <location>
            <begin position="93"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR606225-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH81912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="313" mass="33714" checksum="DC9F51D3F84E7515" modified="2015-07-22" version="1">MSTVPEIRTLPVPDGLEGERLDAALARMFGFSRTKAAELAGAGKVLVDGREAGKSDRVTAGAWLEVEMPAPAAPVRIVAEPVPGMAVVYDDGHVVVVDKPVGVAAHPSPGWSGPTVVGGLAAAGYAISTSGAAERQGVVHRLDVGTSGLMAVAKSERAYTLLKQQFRERTVDKRYHALVQGHPDPLSGTIDAPVGRHPVHDYKWAVVADGKPSVTHYDLVEAFRAASLLDIKLETGRTHQIRVHMSAHRHPCVGDLTYGADPVFAKRLGLDRQWLHAVRLGFEHPEDGRWVEFESDYPEDLRQALDTVRADSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N579</accession>
    <name>A0A0F7N579_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Pyridoxal-dependent decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_10360</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4 5">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the group II decarboxylase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015905.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_10360"/>
    <dbReference type="EnsemblBacteria" id="AKH82563">
        <property type="protein sequence ID" value="AKH82563"/>
        <property type="gene ID" value="AA958_10360"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_10360"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2183"/>
    <dbReference type="OrthoDB" id="1478871at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010977">
        <property type="entry name" value="Aromatic_deC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00800">
        <property type="entry name" value="YHDCRBOXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="491"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="499"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4">
        <location>
            <position position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH82563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="526" mass="55590" checksum="EDFE36D10DE9F5B8" modified="2015-07-22" version="1">MRSHLLNDRTAGAYRRTVTAGVEHIAARLAHADRPFTGITPPALAPVVDAVDLDLPLGDAGAALAELDRLYLRDAVYFHHPRYLAHLNCPVVIPAVLGEAVLSAVNSSLDTWDQSAGATLIERRLIDWTAARIGLGPAADGVFTSGGTQSNLHALLLAREEACDGVRKQRGTGLRTAEILPRLRILASAHGHFSVRKAAALLGLGEEAVVEVPCDAERRMRPAALAAALARLQRDDLVPMAVVATAGTTDFGSVDPLAQLAGVCAGYGVWLHVDAAYGCGLLVSGRRRHLLAGIERADSVTVDFHKSFFQPVSSSAVLVRDRAALRHATYHADYLNPERMAAEQIPNQVDKSLQTTRRFDALKLWLTLRVMGADGVGALFDEVCDLAGAGWRLLDADPRFEVVVRPQLSTLVFRYVPDGPAGTDPARVDAANLRARERLAASGAAMVAGTKVDGRHHLKFTLLNPETTTEDLAAVLDLIAAHAADHTGESLVPEAPAADPAAPAVPAGPAVPAVPAGPAAPPVPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N589</accession>
    <name>A0A0F7N589_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_10275</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015891.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_10275"/>
    <dbReference type="EnsemblBacteria" id="AKH82549">
        <property type="protein sequence ID" value="AKH82549"/>
        <property type="gene ID" value="AA958_10275"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_10275"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2165"/>
    <dbReference type="OrthoDB" id="990666at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519068" evidence="2">
        <location>
            <begin position="25"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="HTH lysR-type" evidence="3">
        <location>
            <begin position="2"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH82549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="301" mass="32164" checksum="0CD830CEA770F55D" modified="2015-07-22" version="1">MLDLSRLRALHAVAVHGSVGSAAAALGYTPSAVSQQIAKLERETRTPLLERRGRGVTLTDAAQHLAATAEQLLAIVEEAETSLEERRGRPMGRLTVACFATAARGLLPAALAALAAEHPALDTRMLEADPHLSPGMVTRGVADLAVAHDWDIAPLPTPEGMELASIGDDLCDICVPAGHPFAGRDRLVRADLVGERWICQPPGSTCHDWLVRTLRTSGHEPDLAYQVAEYASQLALVAAGLGIALVPRLGRGPLPAGVVAVPLEPVPVRRVYALWRTGAARRPAIREAVRLLQREWKERVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5D1</accession>
    <name>A0A0F7N5D1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_07035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015363.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH82012">
        <property type="protein sequence ID" value="AKH82012"/>
        <property type="gene ID" value="AA958_07035"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_07035"/>
    <dbReference type="OrthoDB" id="1994066at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="77" mass="8305" checksum="BE5E577DCC81C0D2" modified="2015-07-22" version="1">MPSSPSSSPSWPPHRPTVAGLLRTIEGVLLRGEQRTARRNAWDAVLEDRRRASARRESESAVSQADPSAGGTSALPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5H2</accession>
    <name>A0A0F7N5H2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endopeptidase La</fullName>
            <ecNumber evidence="1">3.4.21.53</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_10805</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of proteins in presence of ATP.</text>
            <dbReference type="EC" id="3.4.21.53"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S16 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.53" evidence="1"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015973.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_10805"/>
    <dbReference type="EnsemblBacteria" id="AKH82633">
        <property type="protein sequence ID" value="AKH82633"/>
        <property type="gene ID" value="AA958_10805"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_10805"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2273"/>
    <dbReference type="OrthoDB" id="1324470at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008269">
        <property type="entry name" value="Lon_proteolytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027065">
        <property type="entry name" value="Lon_Prtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10046">
        <property type="entry name" value="PTHR10046"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05362">
        <property type="entry name" value="Lon_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51786">
        <property type="entry name" value="LON_PROTEOLYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0720">Serine protease</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519807" description="Endopeptidase La" evidence="2">
        <location>
            <begin position="28"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Lon proteolytic" evidence="3">
        <location>
            <begin position="142"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH82633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="250" mass="25586" checksum="CAED8D9C019C2D09" modified="2015-07-22" version="1">MTLALCAAPVAGLLAAAAFAPLPFSLAKPGMTADVLGDHRGSPVITVSGAEQHATDGELRMTTIAATGPEVDLRLADIASGWFATDEAVMPKDAVYPVGDSRKEIREYNAEQMRESQNTAVTAALNHLGRKPGSVDVELRLTDVGGPSAGLFFALGIVDKLGPDDLTGGRVVAGTGTIDRDGTVGAVGGVPLKTQAAKRDGATVFLVPKAECADAQSELPEGLRLVPVEKLSDAVTSLKALESGGDVPSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5J9</accession>
    <name>A0A0F7N5J9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH iclR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_11085</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ROK (NagC/XylR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016022.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_11085"/>
    <dbReference type="EnsemblBacteria" id="AKH82684">
        <property type="protein sequence ID" value="AKH82684"/>
        <property type="gene ID" value="AA958_11085"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_11085"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2334"/>
    <dbReference type="OrthoDB" id="1130699at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
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        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
            <begin position="20"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="391"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH82684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="433" mass="44654" checksum="40AC8DFF7B1B4E00" modified="2015-07-22" version="1">MASAAELGGDLSRLRHLNSLAVVDVLRGAEPLTLTAVAERAGLSRPSTKDVVGQLVELGWVQELGPAQGTVGRPARRYRFRADAGHVAGIDIGVHSVRAAVADLDGTVHAQTHRTVGPATPVDDRIAAADLAVADCLTAVGLRREDLWAVGAGTTGIVDRAGTVQFCAGVANWTGVDLAARIGALFPCAVQIDNDSRLAALAERQWGVAKGVDDTVFLHAGRRTGAALVVGGQVHRGFGGVAGEVGMHPVTHWVTAASYLHDCPAVPPDVPKSDAARHTFAAARGGDPLAVAAVERYCDDLALGTSAMVMTLDPELVVLGGAFSRAADVLLPRLRRRLEDVCLRVPELRASALDEECVAVGAIGRAVAYLDGELFGGAAGQIVPLHDLAAGDGKAAESPGHPGDQRHPGVRAQRRDPGDQGAPGPDRAAGGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5S9</accession>
    <name>A0A0F7N5S9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_07930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015522.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH82172">
        <property type="protein sequence ID" value="AKH82172"/>
        <property type="gene ID" value="AA958_07930"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_07930"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1670"/>
    <dbReference type="OrthoDB" id="1261526at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH82172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="244" mass="26286" checksum="6814D9C81F139669" modified="2015-07-22" version="1">MTFAGQRVVITGASRDFGRTLAIRFARRGAEVFVSSRSLAASRRVADEIRDLGHTQVHALVCDLSDPASVRRFAADVAQRTDRVDVLVNNGARWLGGPDLLSATDEDVIDTVAAGATGTILVVKRLLPLLLASDRPDIVNMISAAGLPAHQRSDAHDAFYAAKSAQAGFADILSTRLRPRGVRVISLYPPDFSNPDPLSPEWESTPRGSGDMLTAHSVAECVFFALGQPRDCFIKAFHFEQACG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5T0</accession>
    <name>A0A0F7N5T0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_11530</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_11530"/>
    <dbReference type="EnsemblBacteria" id="AKH82759">
        <property type="protein sequence ID" value="AKH82759"/>
        <property type="gene ID" value="AA958_11530"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_11530"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2426"/>
    <dbReference type="OrthoDB" id="665798at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013595">
        <property type="entry name" value="Pept_S33_TAP-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08386">
        <property type="entry name" value="Abhydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519098" evidence="3">
        <location>
            <begin position="31"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="4">
        <location>
            <begin position="101"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="Abhydrolase_4" evidence="5">
        <location>
            <begin position="343"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="33"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="268"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH82759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="455" mass="48466" checksum="8757D83CAB9AEEBB" modified="2015-07-22" version="1">MASPRRRPGRQAPVLALLTALALAWTGACALPGGDGREPSGAATSSYDPDPGGDEWTPCPLTGMERRECRGVTVPVGGGSHETLRLALSRLPARDAGRRIGALVLAPGGPGLSGLQEAVSAGVDYPRALRDRFDIVGYDRRGTGRSHRVDCGEPRGALDRLGSARSLRLVRDVIAVDAAARDYVEGCRLSYGPLLARLGSRAGATDLERVRRALGEERVSLLLHSYATVAGQVYVTRHPERVRAAVFDGVVDPDRRGPSYVLRTLHTRQELDDEQVPEPGPRAAPKAVPSDVRAAFDELDPGPPPLALFLGVHCTDFRWPGNLRALLRELDDAREARWRTRTVARDYAPCVHWPGRGEPLGAVRPGTGDRGGDGARAGDYGAADGADLLLINSEDDIRTPAAGAERVAMRFRAPLLTVPGGRHGLVGFGNECAERAAVEHLTARPAAAPDANLIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N640</accession>
    <name>A0A0F7N640_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chemotaxis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_19820</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017345.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH84055">
        <property type="protein sequence ID" value="AKH84055"/>
        <property type="gene ID" value="AA958_19820"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_19820"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4176"/>
    <dbReference type="OrthoDB" id="1384345at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="141"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="279"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="304"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="336"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="366"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="15"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH84055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="414" mass="41329" checksum="FD9F7AE0A8C4CA02" modified="2015-07-22" version="1">MSPTAPRAGARLPVAVYVLGVAVFALGTSEFMLSGLLPEIADDLDVSIPRAGLLISAFAVGMVVGAPTLAAATLRLPRRTTLVGLLVVFGAGHIVGAVSTSYGVLFATRIVSALACAGFWAVGAAVAIATVPAGARARAMAIMVGGLSVANVAGVPGGALLGQHFGWRSAFWAVTLMTAVALVGVVALVPGGTPGDAEPPRLREELRIYRDGQVWLAMATIALFAGATFSFFSYLAPLLTDVAGLGDGWVPTVLALFGAGAFLGTLVGGRMADRYRFGTMYVGLSATAAVLVACALLAEYPVAIVTLSILLGATAFTTAPALNARIFDVAGDAQGLAGATATSSFNIGNTVGPWLGGLVISAGLGYAATAWTGAVLAVGAVAMTVVAGRSAARRTRLVACGGEPAAEGAVKAVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N652</accession>
    <name>A0A0F7N652_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_19925</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="gene ID" value="AA958_19925"/>
    </dbReference>
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    <dbReference type="PATRIC" id="fig|444103.5.peg.4198"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH84075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="74" mass="8035" checksum="F335BF372F5E7F2E" modified="2015-07-22" version="1">MTHASAEEIVALVALDLKVATGRWGNLTPERLDAVAGSFGPEYQEAFDFGTGAARPVDPAFTEFTPPRFLRPTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="17" xmlns="http://uniprot.org/uniprot">
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
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            <begin position="12"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
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            <dbReference type="SMART" id="SM00418"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AKH83556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="188" mass="20937" checksum="1CF13B5855F83D37" modified="2015-07-22" version="1">MTDERRKVSSPEALKALAHPLRLRILRHLSVHGPATSTTLAAALDENTGTLSYHLRMLERGGLIEDIPERSAGRERWWRGVPGLDIRRPPMDDVTAGERAVIAELDRLRGAEDLELARRYAAGQGGEGGESEEGWLRGSRGLSHLTKEQLDAFHDDYLKLLAKYRHTPEDAAPGARPVHLRWFGIPAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6F8</accession>
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        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="198" mass="21448" checksum="8047FB83DDA71F58" modified="2015-07-22" version="1">MPTRTEFLPAAHNDDDFDTFGTDTARSAIARFRSPMTRMLLGSDGLTTTLLESWAGTPMRVGDVALRVVRPELAPRGVVALLGTEGEVLVRHSTLTDAGGRRWSWNRVVAGPGGDPALRRCLTDAAVPLGPALRAAGARLERTVVRAGVTPWPPEPRAEEPRPAAFRTYRLWRGDDVLAAVHEVFNPAHVPADLEETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6H1</accession>
    <name>A0A0F7N6H1_9ACTN</name>
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        <submittedName>
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        </submittedName>
    </protein>
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    </gene>
    <organism evidence="3 4">
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="Tad" evidence="2">
        <location>
            <begin position="28"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH82993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="164" mass="17518" checksum="AE0422F51D473962" modified="2015-07-22" version="1">MTRVRVAAARLRAGLAGRVRMLDDRGSGAGAVIIFAFLFMALAAFVVDGGLAISQRERAADIAEQAARYAAQDTDKEALYEGQTDLEAPIRFENCDSRVQEFMSHVTVHNGDVEAATCTSAAADHVEVEIVLSYRPLLTGLALSGPLEATGRARAEPRTEVGEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6H6</accession>
    <name>A0A0F7N6H6_9ACTN</name>
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        <submittedName>
            <fullName evidence="3">Type II secretion system protein E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_13035</name>
    </gene>
    <organism evidence="3 4">
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        <lineage>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="98"/>
            <end position="349"/>
        </location>
    </feature>
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        <source>
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        <source>
            <dbReference type="Pfam" id="PF00437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH82998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="438" mass="47935" checksum="73261B46F7ECC466" modified="2015-07-22" version="1">MSSGPAVDHGLVKRFRQEAGDRIARQRHEDQLAHVTPMSAEDERHFARAVIAQILEDYARSEINYGRTPLDAETEEAYAAAVHAALFGVGRLQPLLDDPEVENIDINGFDHVFVGYADGREAKVDPVAESDEELVELIQILGAYSGLSSRPFDSANPQLDLRLPDGSRLSAVMDVTRRPALSIRRARLGKVFLPDLIGNATITAELGSFLTCAVRARKNIMIAGATNAGKTTLLRALANEIPAPERLITVERALELGLDQFPELHPNVVAFEERLPNSEGHGAITMAELVRRSLRMNPSRVIVGEVLGDEIVTMLNAMSQGNDGSLSTIHANSSSEVFNRISTYALQASERLPVEASQMLVAGAIDFVVFIERRNLYHQGGGLQRMVTSVREVNGVDGRVMSSEVFKEGPDGLLHPHAPIHCIDELIPFGYQPSGDWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6I6</accession>
    <name>A0A0F7N6I6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cell division protein FtsK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_13090</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
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        <lineage>
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    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_13090"/>
    <dbReference type="EnsemblBacteria" id="AKH83008">
        <property type="protein sequence ID" value="AKH83008"/>
        <property type="gene ID" value="AA958_13090"/>
    </dbReference>
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    <dbReference type="PATRIC" id="fig|444103.5.peg.2754"/>
    <dbReference type="OrthoDB" id="7548at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002543">
        <property type="entry name" value="FtsK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01580">
        <property type="entry name" value="FtsK_SpoIIIE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50901">
        <property type="entry name" value="FTSK"/>
        <property type="match status" value="2"/>
    </dbReference>
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    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="352"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="375"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="FtsK" evidence="4">
        <location>
            <begin position="814"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="domain" description="FtsK" evidence="4">
        <location>
            <begin position="1150"/>
            <end position="1345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="39"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="225"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="313"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="88"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="225"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="832"/>
            <end position="839"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
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        <location>
            <begin position="1167"/>
            <end position="1174"/>
        </location>
        <ligand>
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        </ligand>
    </feature>
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            <dbReference type="PROSITE-ProRule" id="PRU00289"/>
        </source>
    </evidence>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH83008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="1642" mass="175705" checksum="1ACAB924018FE3ED" modified="2015-07-22" version="1">MRLTLTVVDPLGGDRADVVLDAEAESSVGDVARVLAGQLDSPPPAAVPHGAPQAAQVPASHAQQAQHAHAQAAPAQMPGGWATAGAPPAAPPGSPPAAVPFGAPGAPPQQPAAAPAPPPVFVDGFAVDPRLPVAQSPLREGTVVSLYDPVGCPPREVTGLVELRVVGGPMAGAVHRLGLGRVDVGSGNATHIRVSDPELPERAFSLTVSADGTCKVHVHGDQEKATLDGTTFAERAKPKEKSDDDDTRRARRRRRREARREERRRRRAGEPAPPPLPQEPPQSKDAWPYGAQVAMGNSLFELVRYAPPDAAVATSEDGAGLDYNRPPRLLPPDRETRFKLPAPPKEGQARPLPWLMALMPAVMGVTMCLVMGRWYYLLMAFMSPIIMIGNYFMDKKHGRKSHVKAVAEYKEHKARIEKDARDALVAERNERRLGGPDPALLLSTATGPRTRLWERRRTDADHLLIRFGTAELDSEVLLEDPEQDEHRRQVLWKIQDAPVTVPLRQIGVLGIAGAGDTPRSLGRWAVAQSAVLHSPLDVQFYVLTEPGGQAGWDWMRWLPHARPAGEYDTNALIGTDTETVAARIAELTQLLDARQKAAKDQRSSGPTSFKDPDIVIVFDGSRRLRSLPGVVRLLREGPAVSMFAICLDSEDRFLPGECQAIVVAEPKPEEHDPRAAAAQGIPLQQVAGAGGPGGPGGYPPFQVGAWGNGQAQDAAQRAAAADGTGPIRLRVEQAGSERRRGVRPDFVSPAWCALVARGLSPVRDISGEAEDAAIPSSSRLLDVVELEPPTGDAIAARWQIGGQSTTAVIGESYDGPFAIDIRKDGPHGLIAGTTGSGKSELLQTIVAALAVSNTPENMTFVLIDYKGGSAFKDCVKLPHTVGMVTDLDNHLVTRALESLRAELHRREHILADAEAKDIEDFQDLLRREPGRYAPLPRLLLVIDEFAAMVRELPDFVTGLVDIAARGRSLGIHLMLATQRPSGVVSPEIRANTNLRIALRVTDGGESADVIDAPDAGFIAKSMPGRAYVRLGHASLVPFQSGRVGGRRPGAADPATAQPWAGRLGWAELGRGALKRPAGAQQEEDEITDLKVLVDAVNEANERLGIPEQHSPWLPALPDSIELDALPAPQGAGPLPPAPYGIEDLPAQQARRTVAIDFADFGHLIVGGAPRSGRSQMLRTIAASLARTHSVADLHLFGIDCGNGALNALTRLPHCGAVVSRNQTERAVRLIGRLKQELGRRQELLAADGFADIAEQRAAASDPEQKLPYTVVLLDRWEGWLPTLGEINHGDLTDEIYGLLREGASVGIHMIITGDRSVLTGRISTLTEDKFAFRLPDRSDFSMISLNARNIPEDIAPGRMFRAESGLETQIAVLSDDLSGAAQAAAVAAIGEAATARDAAVPRSLRPFRVDVLPSRLGFEEAWEMRDVQAQEASKLWALVGVGGDELMGFGPDLADGIPAFIIGGPAKSGRSTVLKAMALTFLQQGVRLVIAAPRPSPMRELADREGVLQVFTEDDIDEDEVHDLLRQASPDEPIVVLVDDAEMLTNCDAGDEFKAIARRGAERGWALVLAGDEEEVASGFSGWQVEAKKARRGVALSPQDPSAGDLIGIRLNRGSVGDQVQPGKGLLHLGDGEPFAVTTPLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6L4</accession>
    <name>A0A0F7N6L4_9ACTN</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">AA958_21135</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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        </lineage>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH84280">
        <property type="protein sequence ID" value="AKH84280"/>
        <property type="gene ID" value="AA958_21135"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_21135"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4451"/>
    <dbReference type="Proteomes" id="UP000034283">
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH84280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="70" mass="7602" checksum="40F87D42FAB28638" modified="2015-07-22" version="1">MRDRSKCARYAVGVGPTWAAMCLRSESALPAEMHEALVKPGHPFVVDYSETEKALGVAATVVDEVLREVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6R7</accession>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH82497">
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        <property type="gene ID" value="AA958_09905"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_09905"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2086"/>
    <dbReference type="OrthoDB" id="1994413at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045608">
        <property type="entry name" value="Trypco2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19631">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trypco2" evidence="1">
        <location>
            <begin position="11"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="99" mass="10851" checksum="BBE54589C3B57112" modified="2015-07-22" version="1">MAHEARSDELVGLAEAIAEVRRELVQAEREGERSDWRFRVERVSLEFAVELHRTGEGRLSLRLGVVEAGAGGSATRVGTHRVQLDLVPHGAAGDRPVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6T2</accession>
    <name>A0A0F7N6T2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_18005</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017087.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_18005"/>
    <dbReference type="EnsemblBacteria" id="AKH83786">
        <property type="protein sequence ID" value="AKH83786"/>
        <property type="gene ID" value="AA958_18005"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_18005"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3787"/>
    <dbReference type="OrthoDB" id="537440at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519314" evidence="1">
        <location>
            <begin position="33"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase" evidence="2">
        <location>
            <begin position="49"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH83786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="387" mass="40945" checksum="F2CC066FFB9793CD" modified="2015-07-22" version="1">MNRTRTRTRTRTRTAARRAGAAALLAAVVAGAAAPAAAHGTGRATDPVQRRLDALVERDGVPGALAYDGRTTRTAGVADTATGRPMVGAEGRYRMASNTKAFTATAVMRLVAAGEVRLDAPAARYVPQLAGTGVTVRHLLKQTSGLPEYLQFVDWSRAATEEEYLALALGHPADFEPGARWGYSNTNYLALGLLIKHVTGEDYRTYIERTLIEPLHLKDTYWPAQGELTLRGPHARNYGVHPVDPGAGVTDVTELPGYEFGASGGLVTTPKDQNTFWDALFGGRLLPGWALRAMTHDTTDVGGQDTYPEGSRYGYGVASFPLSCGGVYWGHGGDLPGDSVAGGRAGRGRGTVTVYTTTWAAEGGRLADLQGAADAALCAKDRTGKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-10-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7J6</accession>
    <name>A0A0F7N7J6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_15315</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016666.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH83353">
        <property type="protein sequence ID" value="AKH83353"/>
        <property type="gene ID" value="AA958_15315"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_15315"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3224"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH83353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="74" mass="7384" checksum="C2A7120F76273856" modified="2015-07-22" version="1">MAHNPQGQQPDPHDDPAGSTQMFRAFVDEGGGPQARGPQQPAAAAASSGPRVGMIIGIVVAVAVLAGVVWLAVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
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    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
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        <lineage>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
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        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="283" mass="29122" checksum="27610CFB7978A5E8" modified="2015-07-22" version="1">MTPLIAAAVLAAAVMHASWNAIAHGFKDQLVVFALIGVGDVLIAGTAVIFVPVPDAGAWPWLLASVAIHLVYMTLLMQSFRLGDFGQVYPIARGTAPLVVAAVAHLFLGERLGLWQTAGVAVACAGLSGIALWGLRGKDTRPHWPALAAAFATGLSIAAYTIVDGVGVRASGSAMGYTAWLVLLMGPWIPLAALVLRGTRMVRELAPVAARGLLGGAISITAYGLVLWAQTRAPLAPIAALRESSIVVGAAIGAVFLKERFGGPRIVAACLMVAGIALVLLPA</sequence>
</entry>
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                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4 5">CNQ-509</strain>
        </source>
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    </dbReference>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH84141.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="355" mass="37254" checksum="A8FA03A0C92A2E34" modified="2015-07-22" version="1">MLVDAGSNPFEMGIATELFGLRRPELDVAWYDFTLCAPAPGVRMHDGFFTLSGVPGLEAADAADTVIVPNRPDDTPPTAPVVAVIRRAADRGARLVSFCTGAYALAAAGVLDGRPAAIHWRWADRFAARHPAVRVRRDVLFVDDGDVLTAAGSAAALDLGLHLIRRDHGAEVANHVSRRLVFAAHRDGGQRQFIERPVPAVPDASLAPVLAWAAERLDRPLAVADLAGYAAVSPATLHRRFVRELGTTPLAWLTGERVALACRLIERGEHRLEVVARTSGLGTAANLRTQVRRRTGLSPSAYRARFGPAGAAGPESGPGTRSGSGSGPGSATPPVPGPAPVPVPENGSGPAPRPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-08-12" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N838</accession>
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    <protein>
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    </gene>
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        <lineage>
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        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
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    </dbReference>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="178" mass="19619" checksum="DE46181E726B7C0C" modified="2015-07-22" version="1">MTVGDNATEAPREAPRPTGVLRRTAEGHDLVLSRTFRAPAADVWSWLTEPERTVRWFGQWEGDAAPGRTVRVRMAYEDGAPWSDLRIDACEAPHRLAVSMVDEAGDWRMEALLAEAGGGTRLELIHHLASVEGVGEVGPGWEYYLDLLVAARDGAADTAAPSFDDYYPAQRDYFTSLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N859</accession>
    <name>A0A0F7N859_9ACTN</name>
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        <recommendedName>
            <fullName evidence="3">F5/8 type C domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="4" type="ORF">AA958_17070</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_17070"/>
    <dbReference type="EnsemblBacteria" id="AKH83638">
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        <property type="gene ID" value="AA958_17070"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_17070"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3589"/>
    <dbReference type="OrthoDB" id="50834at2"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
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        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
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        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519294" description="F5/8 type C domain-containing protein" evidence="2">
        <location>
            <begin position="34"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="3">
        <location>
            <begin position="615"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="629"/>
            <end position="650"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH83638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="840" mass="88998" checksum="A445A7CF1F9F021B" modified="2015-07-22" version="1">MATPTPFPRRRFLLASGATAAGLALGTPGIGAAASGPGPEALLYHRLLLRHTRWVETQWDDAAGRYPLADFGFVSVLGNAVLLTHGTYDADLAGVDRDTLADHTVRTIRHFAATNFWATGATWGGGGYEWGGRVFWDGTFESYFVAAARLLWDDLDAATRAHVDAIAVRGAQYVAGLGAGEDPRSGGWSSNGLTGGHRGDSKIEEMGAKSMPLATGLAYHPGHADAPAWREWLTRWMSNMTGLPSADRENGTLIDGRPVSEWNTAQNMYEGHVVENHGTYAPMYQQSTGAYPGRNALHFLIAGAPLPEVLAKQPNAAGLWHTMTHLGTAAGLSSHPMVADRYHLYGRDVLPLTWRRMGQADPYTARAERMLAAHLEPYLAYPPENRLTKFSGEPKYEPEARAEVAIAYLLHVWRDRLHGDVRPVSEARYWASVTGATDYGAEVGLVAHQSAQALAMAVSKAGHVKFAFLPEHDDWLFDVTGAAPAFLPGTALAVTGRRVARYTRAADGFDGSATVLRLAQGTAGYATLPTGAVVYATSGLAADEGRLRLHTLTMPGVRGLDGDRTFHGPGGAVTLAPDGGDGGVDEVRFPAVAARHVRILGARPATQYGYSLWRVEVYAPGSATDLARGRTATASSADPAYPPPHATDGDPATRWAVARAERPRADSWLAVDLGAEQRVDRVLLGWEAAYGAEYRVQVSADGTGWRDVAAVPTAHRFTGNWVNVDDRAGFVVRGGSNPIRVTAGSVTLSAGPDAPLIAEGYPAQRAGRTRALAAAPAPTTDVPDVAAALADGHLAVFNLTDAPVRATVHVPAGTDGEPARTVRVDLPAAAATILPPASGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8D2</accession>
    <name>A0A0F7N8D2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_24290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018067.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH84815">
        <property type="protein sequence ID" value="AKH84815"/>
        <property type="gene ID" value="AA958_24290"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_24290"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5118"/>
    <dbReference type="OrthoDB" id="2059111at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH84815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="61" mass="7314" checksum="779F269FDA801844" modified="2015-07-22" version="1">MKYQLASTGLTANDIASIWRIPKGTVYRYAHMHRWRRYKQIGRVYYHPDDVTATLEEMQPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8E8</accession>
    <name>A0A0F7N8E8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_17570</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017018.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_17570"/>
    <dbReference type="EnsemblBacteria" id="AKH83714">
        <property type="protein sequence ID" value="AKH83714"/>
        <property type="gene ID" value="AA958_17570"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_17570"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3699"/>
    <dbReference type="OrthoDB" id="1303819at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013519">
        <property type="entry name" value="Int_alpha_beta-p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01839">
        <property type="entry name" value="FG-GAP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00191">
        <property type="entry name" value="Int_alpha"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="SSF69318"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51470">
        <property type="entry name" value="FG_GAP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519859" evidence="5">
        <location>
            <begin position="33"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="259"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="313"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="319"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH83714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="495" mass="48095" checksum="A30F45544459423B" modified="2015-07-22" version="1">MHHRLRTALATATAAAALSGGLAALAAPGAAAAEPPGAIVDFNGDGDPDVAVSAPDAYVAGVRGAGQIVAHYGAENSTAAGITARRAKRLSQHSAGVPGTAEDGDGWGGWTAAADLDGDGYTDLAVAAPGEKVGGDVNGGTIQILWGGSQGLAGGTTLPDPRPYEHDLFGRGIAAGDFDGDGTADLAVASTSASMDVFTGGFGRTKGDYGAWDTVAVPLDNGRIWGRFDLAAGDVDGDGDDDLVVNGHVDWERSGVYVPGSPDGLTDAGQRQLSGGDTTVVGDVNGDGRADIVTGLTRDDQGTPGAAVGGKVSVTLGSADGPAGTTDLSQATPGVPGTPEQGDSFGGQLALGDVNGDGHTDLAVSAANETLGAAENTGTVTVLYGAADGSSSGSGSGSGFGGAGATLVHQNTPGVPGTNETRDRFGVGILLSDLNGDGFDDLTAGAAGENDGNGAVYALRADAGGVAADGAAAIYPSSVGMPTTGRPGYGAEFAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8K5</accession>
    <name>A0A0F7N8K5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Type VI secretion protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_17970</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017081.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_17970"/>
    <dbReference type="EnsemblBacteria" id="AKH83779">
        <property type="protein sequence ID" value="AKH83779"/>
        <property type="gene ID" value="AA958_17970"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_17970"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3780"/>
    <dbReference type="OrthoDB" id="1077351at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="96"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH83779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="511" mass="53979" checksum="F304F1C6322A3F1F" modified="2015-07-22" version="1">MAQGRGGRNRGGGQQGSPERGIPDALLLGVLAFLLGLTILAWTATGLSGLLAHGAWPDGVTFTRTPLAMRELVSEPHDLPAAWPDTPRESLSGWGLFWGVFISQLMVLGTFTLAGMTTMASLRARRAAARKAAAGDEALAGGLEHRYEEQDRYEDTESAAQPTPRRRPPVRPAHDPRPQPTQPLPTVPRQRPAQPSAGLPPVHAGPLVFRKGSPTAMAVTRETLLGAEGPALVITSDASLWADTKDARGKLGPVLVYDPGQLCDTPDRLRWSPAAGCADRETASERAAALLRPVRPQHRTDTTVADTAETMLACWLHAAAVGDRPFAQVHRWAQGTGAHEPVGILRSAPEAASGAAGELESALTGHPERRDAAAELVATALEGMSSIHMRNASKPTRADSLVLESFIDEGGTLYLVGEAIEGPRSRPGAMPLLTALATDVVEHGRRMAARSSTGRLDPPLTLVLDDVAAVAPLAGLPALLTEGDREGLPTLATMRSPEQARSRWPGLSLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8V4</accession>
    <name>A0A0F7N8V4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_19015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017233.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_19015"/>
    <dbReference type="EnsemblBacteria" id="AKH83938">
        <property type="protein sequence ID" value="AKH83938"/>
        <property type="gene ID" value="AA958_19015"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_19015"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3992"/>
    <dbReference type="OrthoDB" id="1331608at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="248" mass="27094" checksum="755584D3328CE8C9" modified="2015-07-22" version="1">MSPTHPELPRKKPPEVDFAVDQLDADEKVSRAFHVLVGLHAGSLVSLAEHHTADGLRSYYVLFDSSATWGHPGEAPYVGVYLKRDPDKRTFAFNHDVLPLPAMVQCWLIHRGCPPDAITLDPELGPQPADEATRALGRRLMFEGDDYGVGFSYNRDDPDDFVTVVAMGAADEHAVPPFRVVVEEVDTDAQTYTLREGGFATPQEAWGWCWDRLAGDAGPLPPMRPAAANPRPPGLPGAPARRPTGPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8X8</accession>
    <name>A0A0F7N8X8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Aminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_18550</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017171.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_18550"/>
    <dbReference type="EnsemblBacteria" id="AKH83874">
        <property type="protein sequence ID" value="AKH83874"/>
        <property type="gene ID" value="AA958_18550"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_18550"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3893"/>
    <dbReference type="OrthoDB" id="1465483at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
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        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="PTHR12147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="8" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519324" evidence="6">
        <location>
            <begin position="34"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="7">
        <location>
            <begin position="387"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="27"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH83874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="476" mass="50953" checksum="ECD0CC608D4C27C3" modified="2015-07-22" version="1">MSPHPRGTNRRTVLAAGAAATAAAGITAGPAAASGPAAPADQGAGRPPATAQRPGRELRALLAEVDAGRIEADVRRLAAFGTRHTLSVQDDPDRGIGAARDWIHRRMRRHAAASGGRMTVELQSYVQQPANRIPVPTRITNVLATLRGDTDPDRVYVVSGHYDSRASDVMDATSDAPGADDDASGVAVAMELARVLATRRTAATIVLAAVAGEEQGLYGAAHMAEQFRAGGVRVQGMFTNDIVGSSTADDGTRDPRTVRLFAEGVPTAETPAEANTRRSVGGENDSPARQLARFVRDVAENDATGMGVRVIYRRDRYLRGGDHIPFLERRFPAARFTEPAEDYAHQHQDVRVEGGKQYGDLPDFCDFDYVARVARVNLAAVWTLAQAPGTPTGVGIVTSALTNDTELVWDRGTEPDLAGYEVVRRETTAPEWTEVEPVGDVTRHTVRASKDNLFFGVRAVNRAGQRSPVAFPVPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9C9</accession>
    <name>A0A0F7N9C9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cytokinin riboside 5'-monophosphate phosphoribohydrolase</fullName>
            <ecNumber evidence="1">3.2.2.n1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_23255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>9-ribosyl-trans-zeatin 5'-phosphate + H2O = D-ribose 5-phosphate + trans-zeatin</text>
            <dbReference type="Rhea" id="RHEA:48564"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16522"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:87947"/>
            <dbReference type="EC" id="3.2.2.n1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + N(6)-(dimethylallyl)adenosine 5'-phosphate = D-ribose 5-phosphate + N(6)-dimethylallyladenine</text>
            <dbReference type="Rhea" id="RHEA:48560"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17660"/>
            <dbReference type="ChEBI" id="CHEBI:57526"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="EC" id="3.2.2.n1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LOG family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.n1" evidence="1"/>
    <dbReference type="EMBL" id="CP011492">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_23255"/>
    <dbReference type="EnsemblBacteria" id="AKH84636">
        <property type="protein sequence ID" value="AKH84636"/>
        <property type="gene ID" value="AA958_23255"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_23255"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4902"/>
    <dbReference type="OrthoDB" id="902542at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102682">
        <property type="term" value="F:N6-(Delta2-isopentenyl)-adenosine 5'-monophosphate phosphoribohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009691">
        <property type="term" value="P:cytokinin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="entry name" value="LOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031100">
        <property type="entry name" value="LOG_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03641">
        <property type="entry name" value="Lysine_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00730">
        <property type="entry name" value="TIGR00730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0203">Cytokinin biosynthesis</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="246" mass="26966" checksum="8FBDAAB6DEDA3BA2" modified="2015-07-22" version="1">MANREEFQEQRLGPVIRRRSRIQRGTMDQHLLDTRERAAEYVHEDPWRVLRMQAEFVEGFGALAEVGPAISVFGSARTAPESAEYARGVAIGKGLVDAGFGVITGGGPGVMEAANKGALEAGGLSVGLGIELPFEQGLNRYVDLGVNFRYFFVRKTCFVKYSQGFVVLPGGFGTMDELFEALTLVQTKKVTRFPIVLFGSEYWGGLVDWLRKTVVDGGKAAERDLDLFHITDDVSEAVALVTKETP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-10-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9F3</accession>
    <name>A0A0F7N9F3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_15185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016651.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH83337">
        <property type="protein sequence ID" value="AKH83337"/>
        <property type="gene ID" value="AA958_15185"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_15185"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3199"/>
    <dbReference type="OrthoDB" id="1681849at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023187">
        <property type="entry name" value="Tscrpt_reg_MarR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01117">
        <property type="entry name" value="HTH_MARR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="134" mass="14547" checksum="1F30F621E741BBBB" modified="2015-07-22" version="1">MSDVGAERALVDRWHGLLACHAAVWGALERELQSRHGIGVSEFEALEGLAASDHDKCRAAELAGAVHLSQSATSRLTARLERAGLVARAMCDVDRRGIFVLLTEEGRRLYEDARPTHREVLAQALPAAEQPAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9L3</accession>
    <name>A0A0F7N9L3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_20255</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017418.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_20255"/>
    <dbReference type="EnsemblBacteria" id="AKH84129">
        <property type="protein sequence ID" value="AKH84129"/>
        <property type="gene ID" value="AA958_20255"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_20255"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4265"/>
    <dbReference type="OrthoDB" id="1680330at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024520">
        <property type="entry name" value="DUF3558"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12079">
        <property type="entry name" value="DUF3558"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519207" evidence="2">
        <location>
            <begin position="30"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH84129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="227" mass="23722" checksum="DEF15E200AD9452B" modified="2015-07-22" version="1">MHRSTTRIPRALAAAAVPVILVTAGCSSGDDGGDSGKPSSAAPSSESSEPQIEPAKFAKLPDPCDALAKDSIKDLVPGAKSTAGEAGKSADTSQRSSCSWDGLDGYQWRWLDVSYQRYDSDPAVGSGADRAAEYYAKQARAAEAAEGAKGMKTSAPSGLGQKAAAFTYETTEDKQDYRKQTVVSLRENVVVTVNYHGAGFQGTDQPKAADLLKDAEKATKEALAAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-10-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9P3</accession>
    <name>A0A0F7N9P3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_20415</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH84159">
        <property type="protein sequence ID" value="AKH84159"/>
        <property type="gene ID" value="AA958_20415"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_20415"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4302"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH84159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="65" mass="7158" checksum="DBF1A7DE67420BAC" modified="2015-07-22" version="1">MNVMETLVTILIVLGAIALGALILHLLNSQRAERLANHYYTPTRRRKGGGKPRRPATKGPLPGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9P9</accession>
    <name>A0A0F7N9P9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CofH_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_20480</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017457.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_20480"/>
    <dbReference type="EnsemblBacteria" id="AKH84169">
        <property type="protein sequence ID" value="AKH84169"/>
        <property type="gene ID" value="AA958_20480"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_20480"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4316"/>
    <dbReference type="OrthoDB" id="940969at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045567">
        <property type="entry name" value="CofH/MnqC-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034405">
        <property type="entry name" value="F420"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43076">
        <property type="entry name" value="PTHR43076"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19288">
        <property type="entry name" value="CofH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CofH_C" evidence="3">
        <location>
            <begin position="99"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="180"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH84169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="205" mass="21611" checksum="9CCDD04158998F62" modified="2015-07-22" version="1">MDAGLRRELAEKARAGARLSRADGVALYGSDDLAWLGGLAHEARTRRHGERGYFATAADPAEPVAEVSYGGEDPAQTVDVLLALRDRQDAGAGLLAVVPLAAGRVTGAAALKTFAVARLLLDNVPHVRAAWTAYGTQTAQLALQHGADDFAPAPGAAGTLPAEELVELIQDAGLHPVERDARYAAVREHAGPDPERREAPQPMRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9Q3</accession>
    <name>A0A0F7N9Q3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fis family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_26990</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018516.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_26990"/>
    <dbReference type="EnsemblBacteria" id="AKH85280">
        <property type="protein sequence ID" value="AKH85280"/>
        <property type="gene ID" value="AA958_26990"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_26990"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5679"/>
    <dbReference type="OrthoDB" id="817710at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="3"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="128"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="128"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH85280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="227" mass="25348" checksum="15E6341BAE9A9880" modified="2015-07-22" version="1">MHRVLVVDDEPQIVRALVINLKARKYEVDAAQDGATALRLTADRHPDVIVLDLGLPDMDGVDVIRGIRGWTRVPILVLSARHSSDEKVEALDAGADDYVTKPFGMDELLARLRAAVRRTEPSAPAGDQAVVTTDAFTVDLAAKKVHRDGADVRLTPTEWHLLEVLVRNAGRLVSQKQLLKEVWGPSYGTETNYLRVYMAQLRRKLEADPAHPRHFVTEPGMGYRFEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NA85</accession>
    <name>A0A0F7NA85_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sulfonate ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_28125</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018694.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_28125"/>
    <dbReference type="EnsemblBacteria" id="AKH85460">
        <property type="protein sequence ID" value="AKH85460"/>
        <property type="gene ID" value="AA958_28125"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_28125"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5927"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027939">
        <property type="entry name" value="NMT1/THI5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015168">
        <property type="entry name" value="SsuA/THI5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31528">
        <property type="entry name" value="PTHR31528"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09084">
        <property type="entry name" value="NMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519239" evidence="1">
        <location>
            <begin position="23"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="NMT1" evidence="2">
        <location>
            <begin position="55"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH85460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="341" mass="35795" checksum="2AB921CBA9B3F1E1" modified="2015-07-22" version="1">MKRTAATLTLLSALLAAAAGCAPDTSDDDGGDSGGDGNGNGKKVTLTLNWVPYGEHAAFYYGVEKGFYADEGIDLEIKPGNGSGATIQQVAQNKTDFGWADTPPLMAGIGEGMGVKSLGVYLQKGPSSVQFVSDENIKEPADLEGKTVAGTPGDAMYATFPGWLEANDVDPSKVKVVNVQPADKISQLAAGKVDAIMGFFHDQGPTIENTTGETVDYILFSDFGMNVLGTGIVASDKMLADDPELAKAFVRATTKSWQEVEANQEEAVKIMSEAATEPPPDNVLANQLKDTLPLLQGDGGGIGVNSEESWQETIDLLSDGGMLKEAKKPADYWDASYAAKG</sequence>
</entry>
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    <accession>A0A0F7NAB8</accession>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Albersmeier A."/>
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                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
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        <property type="gene ID" value="AA958_21745"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_21745"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4580"/>
    <dbReference type="OrthoDB" id="1869056at2"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="DUF3017"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11222">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH84384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="127" mass="13234" checksum="5000B21038787656" modified="2015-07-22" version="1">MARRTAFPTRGTVRPEGGGRAASGKAPPPVRQWPILLVLAIAAAGLITVAAGPFREGTLILGGSLLVGGVLRGTVPEVGMLAVRSRFTDIVTFGVLGLAIVLLALVAMPDPWLEVPFLEDAVHFSVR</sequence>
</entry>
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    </gene>
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        <lineage>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_25505"/>
    <dbReference type="EnsemblBacteria" id="AKH85016">
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        <property type="gene ID" value="AA958_25505"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_25505"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5375"/>
    <dbReference type="OrthoDB" id="2067546at2"/>
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    </dbReference>
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    </dbReference>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
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            <end position="197"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH85016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="211" mass="20377" checksum="2E03B28F295161B2" modified="2015-07-22" version="1">MIALSKTDRAAGAAGTDAADATGVAGTAKTADAPAADEAAYGDTETGDTAEADGADETGGAGKGPDGDEPGELLPAARASTGVAAGAAAIVGAALGLASLTGTWLADLVSARRELTGQLESANGTAAEQISAAYGTPWHTIALFNGLTAVVALIVSAAVLVRPAFGDSGPRPVVWVRAVAVAGVVLGALGLVIAAVMRFDVFAGLPTVPGQ</sequence>
</entry>
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    <accession>A0A0F7NAY7</accession>
    <name>A0A0F7NAY7_9ACTN</name>
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        </submittedName>
    </protein>
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    </gene>
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        <lineage>
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                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000034283">
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="80"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="121" mass="13143" checksum="68B114CE972509B6" modified="2015-07-22" version="1">MLHRPDRAVRERARLLFSRAAASEPDHRELTELLRSPDVLRPCNRLLADLRHRANALLDDLSPDSPCTGLLRARVDAEARPLGVGEEERPAAAPHPVDPGGTPVAPRPRVAPGGEVSQTSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAZ0</accession>
    <name>A0A0F7NAZ0_9ACTN</name>
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        </submittedName>
    </protein>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR011663">
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    </dbReference>
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        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07702">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="6"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="250" mass="27033" checksum="38A3700F584E56AA" modified="2015-07-22" version="1">MPLGEQPAYLRVAADLRRKIVSGELPPHARLPSQARIRQLYGVSDTVALEARKVLMAEGLVEGRSGSGTYVRSRPEPHRLVRTGYRGLADLTPFRQEQADESVTGSWESRSAQEHAGAAVAARLHLGAGDPVMRTRYVFRSAGEPVLLSTSWEPLALTGRTPVMLPEEGPLAGCGVVERMAAIDVVVDNVVEEVGTRPGLAEEAHALGALPGRPVLCIQRTFYASGRAVETADVIVPADRYRVSYHLPVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAZ5</accession>
    <name>A0A0F7NAZ5_9ACTN</name>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_23460</name>
    </gene>
    <organism evidence="8 9">
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        <lineage>
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            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
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                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="cofactor">
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            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
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    <dbReference type="EMBL" id="CP011492">
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    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_23460"/>
    <dbReference type="EnsemblBacteria" id="AKH84673">
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        <property type="gene ID" value="AA958_23460"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_23460"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4946"/>
    <dbReference type="OrthoDB" id="1435118at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000210">
        <property type="term" value="F:NAD+ diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015375">
        <property type="entry name" value="NADH_PPase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015376">
        <property type="entry name" value="Znr_NADH_PPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09296">
        <property type="entry name" value="NUDIX-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09297">
        <property type="entry name" value="zf-NADH-PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="7">
        <location>
            <begin position="171"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH84673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="316" mass="34636" checksum="778C4AF951D00A5E" modified="2015-07-22" version="1">MTTGIERAASRPVSFTADSGVDRAAHHRIDEAWLAAAWSHPTTRVFVVCEGQVLIDDTPDGGTALVTTPAFEAPPTEQHRYFLGTDARGVRYFALQKDSLPGRMDDTARPAGLREAGLLLSEQDAGLMVHAVALENWQRLHRFCSRCGERTVIAAAGHIRRCPACGAEHYPRTDPAVIMAVTDPEDRILLGRQVHWPEGRFSTLAGFVEPGESLEHAVRREVFEEAGVVVGDVEYVASQPWPFPSSLMVGFLARAADAKGAEIRVDGEELHEARWFSRDELGAAYESGEVLPPYGISIAGRLIELWYGSDLPRRPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NB58</accession>
    <name>A0A0F7NB58_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">3-phosphoshikimate 1-carboxyvinyltransferase</fullName>
            <ecNumber evidence="7">2.5.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">5-enolpyruvylshikimate-3-phosphate synthase</fullName>
            <shortName evidence="7">EPSP synthase</shortName>
            <shortName evidence="7">EPSPS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">aroA</name>
        <name evidence="9" type="ORF">AA958_23585</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>3-phosphoshikimate + phosphoenolpyruvate = 5-O-(1-carboxyvinyl)-3-phosphoshikimate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21256"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57701"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="EC" id="2.5.1.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the EPSP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.19" evidence="7"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017949.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_23585"/>
    <dbReference type="EnsemblBacteria" id="AKH84694">
        <property type="protein sequence ID" value="AKH84694"/>
        <property type="gene ID" value="AA958_23585"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_23585"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4971"/>
    <dbReference type="OrthoDB" id="533829at2"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00089"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003866">
        <property type="term" value="F:3-phosphoshikimate 1-carboxyvinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01556">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00210">
        <property type="entry name" value="EPSP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001986">
        <property type="entry name" value="Enolpyruvate_Tfrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036968">
        <property type="entry name" value="Enolpyruvate_Tfrase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006264">
        <property type="entry name" value="EPSP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023193">
        <property type="entry name" value="EPSP_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00275">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000505">
        <property type="entry name" value="EPSPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="SSF55205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01356">
        <property type="entry name" value="aroA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00104">
        <property type="entry name" value="EPSP_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00885">
        <property type="entry name" value="EPSP_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="EPSP_synthase" evidence="8">
        <location>
            <begin position="15"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Shikimate-3-phosphate binding" evidence="7">
        <location>
            <begin position="28"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoenolpyruvate" evidence="7">
        <location>
            <begin position="100"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Shikimate-3-phosphate binding" evidence="7">
        <location>
            <begin position="179"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="334"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="362"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>3-phosphoshikimate</name>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>3-phosphoshikimate</name>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="365"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="406"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="431"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH84694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="463" mass="47721" checksum="7B53BC79D88D40D7" modified="2015-07-22" version="1">MTASQSSPWPAPTAAGPVTAAVTVPGSKSVTNRALVLAALASGPGRLRRPLRSRDSALMAGGLRALGVGMEEGVGPDGTEEWRVTPGGGLRGDAAVDVGNAGTVMRFLPPVAALADGPVRFDGDPRSHERPLHGVIDALRALGARIDDTAQGSPGALPLTVYGEGTLRGGPVEVDASSSSQFVSALLLSAPRFDKGVELRHTGARLPSLPHIRMTVEMLRGAGAEVDAPEDGGEPHVWRVAPGGLRGRDLTVEPDLSNAQPFLAAALVTGGRVTIRDWPRRTTQPGDALREIFTEMGGSCELVTTGDRTDLVFTGASSAGGVRGIDIDLSEVGELTPGIAAVAALAGSPSRLRGVGHLRLHETDRLAALTREINGLGGDVTETADGLEIRPRALHGGVFHTYDDHRMATAGAVLGLLVKGVQVENVETTAKTLPDFPRMWAGLLAGTDTGPAAGAPAAQDPRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBB6</accession>
    <name>A0A0F7NBB6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_23965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018011.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_23965"/>
    <dbReference type="EnsemblBacteria" id="AKH84759">
        <property type="protein sequence ID" value="AKH84759"/>
        <property type="gene ID" value="AA958_23965"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_23965"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5051"/>
    <dbReference type="OrthoDB" id="1120891at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519272" evidence="1">
        <location>
            <begin position="27"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="345" mass="37361" checksum="E0F97CA24B533EB3" modified="2015-07-22" version="1">MRTVRLAILGLATASQLLFCMQSAFAQNGIGLEGDSNPDDGTIGATATQVVVRQTGGGGQGGQPISAVDTNWTPPACWHEPVASPRELEQAVNAIENGNLVPVNSRLQWGVDLMHEYYRDGGDGNPENYNLDKQGKGMWWRAVRNPNREDELEAGDCDQQLMFWADDGAEPDVPTAITPEMLAEYAYDSVKVPDTEIEMQPADDRLKVNLPTWIWQEPAAFDEVRVRAELPGTGLWAETTATPTSLRLDPGTEDAEVHPEGGECAIDDDGSVGERYRRGEPDAVPACGITYRRSSEAAGGSYGLKASITWEVDWTGTGGTGGDLPDGVFETTYDVTVEEIQTVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBJ1</accession>
    <name>A0A0F7NBJ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Allantoicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_28455</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018755.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_28455"/>
    <dbReference type="EnsemblBacteria" id="AKH85521">
        <property type="protein sequence ID" value="AKH85521"/>
        <property type="gene ID" value="AA958_28455"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_28455"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5996"/>
    <dbReference type="OrthoDB" id="906155at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004038">
        <property type="term" value="F:allantoinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050897">
        <property type="term" value="F:cobalt ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
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        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03178">
        <property type="entry name" value="allantoinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="4">
        <location>
            <begin position="55"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="433"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH85521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="453" mass="47439" checksum="66DC692E93FF5906" modified="2015-07-22" version="1">MPDAELVLRSRRVVTPEGVRPAAVAVAGGRIAAVLPYDTPPPPGARAADCGDDALLPGLVDTHVHVNDPGRTEWEGFATATRAAAAGGITTLIDMPLNSLPPTTDTEALAVKQAVARPRAHVDVGFWGGAIPGNTADLARLHAAGVFGFKCFLSPSGVDEFPRLAGTDLERAAAEAARLGALLIVHAEDPDVLDGAPQVPGPGYAGFLASRPRAAENRAVARVVALAERHGTRVHVLHLSSADALPALAAARRAGLPVTAETCPHFLTLTAEEIPDGATEFKCCPPIREAANRDLLWAGLADGTIDCVVSDHSPATAELKTGDFATAWGGISSLQLGLPAVWTEARRRGHGLADVARWMAAGPARLAGLTAKGAIEPGRDADFAVLDPDAAFTVDPAGLEHRNRLTAYAGRRLHGVVRATWLRGRRIHHGGVHTEPRGLLLGRTDRDERQQQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBP6</accession>
    <name>A0A0F7NBP6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Deoxyribodipyrimidine photolyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_24655</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018120.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_24655"/>
    <dbReference type="EnsemblBacteria" id="AKH84868">
        <property type="protein sequence ID" value="AKH84868"/>
        <property type="gene ID" value="AA958_24655"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_24655"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5199"/>
    <dbReference type="OrthoDB" id="215545at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036134">
        <property type="entry name" value="Crypto/Photolyase_FAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007357">
        <property type="entry name" value="PhrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04244">
        <property type="entry name" value="DPRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48173">
        <property type="entry name" value="SSF48173"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH84868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="498" mass="56993" checksum="62281DEA7412178C" modified="2015-07-22" version="1">MHWLFGDQLGPHFLTPGEEGPARDTPLLMIEARSVFRRRRFHRAKAHLVLSAMRHRAAELGDRVAYVRADTYRQGLDRAARGRPVGVHHPTSYAALRLVRGLPRVTVGPARGFLVPMADFAAWADGQGGRRLRQEHFYHWVRRGHDLLMDGDQPVAGRWNLDHDNREPPPRETAALQVARPYRPREDDIDDEVRHDLDRWERDGDVSFVGRDGPRLFPATRAEAKRALRRFVDQRLATFGPYEDAMLAADPVMSHSLLSSSLNLGLLDPAECVEEAEKAWRAGRAPLNSVEGFVRQIAGWREYVWQVYWYFGEDYRRSNELRHTAPPPDWWNDLDADAVRAHCLRTVLAQVRDTGWTHHIPRLMILGSHALQRGWDPAAVTDWFHRCFVDGYDWVMLPNVVGMSQYADGGRMTTKPYTSGGAYVNRMSDLCGPCVYRPGDRTGDHACPYTAGYWAFFDRHRDLLAGNQRVARPLRQLDRLADLTDVREQEHARGDIPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBZ9</accession>
    <name>A0A0F7NBZ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_25225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018214.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_25225"/>
    <dbReference type="EnsemblBacteria" id="AKH84963">
        <property type="protein sequence ID" value="AKH84963"/>
        <property type="gene ID" value="AA958_25225"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_25225"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5316"/>
    <dbReference type="OrthoDB" id="1030857at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="284"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="318"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="370"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="402"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="427" mass="43490" checksum="93B8E4FB85728529" modified="2015-07-22" version="1">MRLAHGVGGTQDLPIPAFYAYAGGFAALLVSFLALGLLWPEPRYAGATAGRPLPRAVRRLAAAPALRRTAAGAGLAAAAFVAGHLLLGPDDPARNPAPGAVYVLLWVGLVPASLLLGPVWRLLNPLRTLHALACRALGRDPAAGRPLPARLGHRPAAAGLLAFTWLELAAPEPAATTALSAFLAAHAAVQLTGAAVYGDRWFAQCDPFEAYSALLARLAPVGRRPADGVLVLRSPLAGLDATPALPGLTAVLCVLLGSTAYDGFSAAPSWIDTLQTSSLGRTATATLGLLTAVALVAVLYAGCAAAVRLVSGRLAHPLSAFAHSLLPIALGYLVAHYFTLFVTEGPRTVTIASGTDNPAPNDPPLSPGGLAALQVTAVVTGHVLGVVAAHDRAVRLFPPARAVAGQLPLLALMVCYTAGGLTLLLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NC13</accession>
    <name>A0A0F7NC13_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_31635</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019243.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_31635"/>
    <dbReference type="EnsemblBacteria" id="AKH86015">
        <property type="protein sequence ID" value="AKH86015"/>
        <property type="gene ID" value="AA958_31635"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_31635"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6681"/>
    <dbReference type="OrthoDB" id="1719670at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010419">
        <property type="entry name" value="CO_DH_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38588">
        <property type="entry name" value="PTHR38588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06240">
        <property type="entry name" value="COXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="212"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH86015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="235" mass="23648" checksum="287A8D2EE30155F1" modified="2015-07-22" version="1">MELRHEFTVPVPADEAWRALLDIERIAPCMPGAAVESFDGETVRGTVKVKVGPIALTYRGTASFREKDEAGRRMVLSANGKEARGTGTARATVTGELTETGGGTRVSVVTDLAVTGRPAQFGRGVLAEVGDRLVGRFAECLAGKLADGGAEVATDAATDADGADAGAGAVRGPGAEPASGLAPAVPAVETSAPGTEPLDLVRTAGVPVAKRAAAGAAVAAALAAVALAVRRARRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NC52</accession>
    <name>A0A0F7NC52_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_30225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH85786">
        <property type="protein sequence ID" value="AKH85786"/>
        <property type="gene ID" value="AA958_30225"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_30225"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6384"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045701">
        <property type="entry name" value="DUF6059"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19534">
        <property type="entry name" value="DUF6059"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="73" mass="8155" checksum="E42043A0C4248C92" modified="2015-07-22" version="1">MRALGKRVTQELHRCLIALGTHYTGRVWQPAPTPDQQQSEPDGPSAGHPERLCPGMALTPLERAIEQELNRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCN4</accession>
    <name>A0A0F7NCN4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_22285</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH84472">
        <property type="protein sequence ID" value="AKH84472"/>
        <property type="gene ID" value="AA958_22285"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_22285"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4693"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="4">
        <location>
            <begin position="156"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH84472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="254" mass="26756" checksum="383AD103F92EA1DC" modified="2015-07-22" version="1">MLVAGLAAAGGGWTDRHRHPVPQLTWAGSGVLMVRALGRTWVLPATTALWIPPGVRHATGTAGTTEPRTLYVRYPGPAPTAADPPLRTRPPADRPGWPEPTVVAVTPLLRALSDHLADDAPAPAARARAEAVLLDQLAPVAPTPVLAPMPHDPRPRAVAEALRDTPADARTLAEWSPYAGAAPRTLARLFVAETGMPFGRWRTHLRLQASLPLLASGATVATAARHVGYASSSAFVAAFHRTVGAPPGTYFPRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCR6</accession>
    <name>A0A0F7NCR6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_26365</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018409.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_26365"/>
    <dbReference type="EnsemblBacteria" id="AKH85168">
        <property type="protein sequence ID" value="AKH85168"/>
        <property type="gene ID" value="AA958_26365"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_26365"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5550"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018391">
        <property type="entry name" value="PQQ_beta_propeller_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002372">
        <property type="entry name" value="PQQ_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13360">
        <property type="entry name" value="PQQ_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00564">
        <property type="entry name" value="PQQ"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="15"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH85168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="690" mass="72137" checksum="879F84DCFC4182AE" modified="2015-07-22" version="1">MKPLGTGDPLRLGPYRLIGVLGAGGMGKVYLGRDSSGRPAAIKVLRPELAHQSNLAQRFVREAHAAQAVQSPGVARVLGAETEGGRPWIACEFLAGPTLAEAVERYGPLDGTALRAVGAALANTLTDIHAAGLVHRDVKPPNIVLTATGPRIIDFGIARPEHGLTLTSTGEAPVTPGYGPPEQVLGQRVGPPADVFALGAVLTLAATGQTAYQGSHVAAVQYEVVHGEPRLEGLPPDLYPLIAPCLAKDPAYRPTPPQIAAALAPPPGAAAVWEQGPLAQDIGGREQEAARLAALPAAGDTQVPGPSRRRLLVGLGAGGAVLAASAGTAAWWWLGKDDGGTTAAPKRDPWAAQPLKSYSSDNAPAALWGPVGGLNSDMPMLLPLRETLVAAMADGSIAGLDIRTGKEKWRQKDAAAASRAAGLDENTFAAADAEGVLYGLRGRDRREQWSAPDARAAVVLAGDRQGAYVTTKDGELRAVGTDGKERWTVPLPVKSTVSKPAWATTADGMLVLSGSDGKLAVVDTRDGTKVWDTPQRSSYALPCAVGGGFVYAGGDGLTAYALKGEGKVEWNEDPKGEYIWSAPALAGGLLYAVNDTQLTVRNARTREIEWTADAGSVALKYPPVVQGNSLWAGTTSSVDPDAIKVYDIDKGRLAWDDRRTSRERDDWTLTAANNRVFVLYTGSLTANPVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCW6</accession>
    <name>A0A0F7NCW6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LuxR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_27250</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018549.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH85314">
        <property type="protein sequence ID" value="AKH85314"/>
        <property type="gene ID" value="AA958_27250"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_27250"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5742"/>
    <dbReference type="OrthoDB" id="1687028at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="4"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="149"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH85314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="220" mass="23366" checksum="ADD5178C59866126" modified="2015-07-22" version="1">MTIRVLITDDQSMVREGFTVLLDAQPGIEVVGEAADGGEAVEQVGLLAPDVVLMDIRMPEVNGLEATRRIAGAGLGTKVLILTTYHLDEYVYEALRAGASGFLLKDASARQLAEGVRVVAAGEALLAPTVTKRLITAFAERKPVLNLPAETRVAGLTGRETEVLALIAQGLSNAEIAARLVVAESTVKTHVGRILEKLGLRDRTQAAIFAYETRLVQPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDF8</accession>
    <name>A0A0F7NDF8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L35</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpmI</name>
        <name evidence="7" type="ORF">AA958_03800</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the bacterial ribosomal protein bL35 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018852864.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_03800"/>
    <dbReference type="EnsemblBacteria" id="AKH86530">
        <property type="protein sequence ID" value="AKH86530"/>
        <property type="gene ID" value="AA958_03800"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_03800"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.799"/>
    <dbReference type="OrthoDB" id="2046660at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00514">
        <property type="entry name" value="Ribosomal_L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021137">
        <property type="entry name" value="Ribosomal_L35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018265">
        <property type="entry name" value="Ribosomal_L35_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001706">
        <property type="entry name" value="Ribosomal_L35_non-mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037229">
        <property type="entry name" value="Ribosomal_L35_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33343">
        <property type="entry name" value="PTHR33343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01632">
        <property type="entry name" value="Ribosomal_L35p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00064">
        <property type="entry name" value="RIBOSOMALL35"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143034">
        <property type="entry name" value="SSF143034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00001">
        <property type="entry name" value="rpmI_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00936">
        <property type="entry name" value="RIBOSOMAL_L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH86530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="64" mass="7310" checksum="87782CE124DD7340" modified="2015-07-22" version="1">MPKNKTHSGSKKRFRVTGSGKVLRQRANRRHYLEHKPSTLTRRLAGTVELSKADAKKVKKLLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NE20</accession>
    <name>A0A0F7NE20_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_12670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020002.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86725">
        <property type="protein sequence ID" value="AKH86725"/>
        <property type="gene ID" value="AA958_12670"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_12670"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2663"/>
    <dbReference type="OrthoDB" id="1788910at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="162" mass="16894" checksum="F1207D5BB0C2076A" modified="2015-07-22" version="1">MLVLTPAGAAYAGSGPAPAPSGKSDRAAATAPTAQGNPDSKRAQAAGVCDDAYQIGATGYIKRSGATVASVKQFYSPSCKENYGYLWVWDSFHTGAKPYDVTLGVFSYDRDAVVGKLTRNDTTQQEFWTQGTATANECTAAVGTLRVEGAPLANQGASEKRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NE54</accession>
    <name>A0A0F7NE54_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_13765</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020032.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_13765"/>
    <dbReference type="EnsemblBacteria" id="AKH86745">
        <property type="protein sequence ID" value="AKH86745"/>
        <property type="gene ID" value="AA958_13765"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_13765"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2899"/>
    <dbReference type="OrthoDB" id="2058880at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019662">
        <property type="entry name" value="DUF2516"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10724">
        <property type="entry name" value="DUF2516"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH86745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="110" mass="11675" checksum="4814592753AAA783" modified="2015-07-22" version="1">MLISGFYSLLGLLSLALTVFAGAALILAALAREDAYRAADKNTKQFWLIILGVGFAVMVIFPIMSFLPIIALIAAIVFMVDVRPALKQVGGGRRRGGSSSDGPYGPFNGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NEE9</accession>
    <name>A0A0F7NEE9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cell shape-determining protein MreB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mreB</name>
        <name evidence="3" type="ORF">AA958_09610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Forms polymers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="2">Membrane-associated.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the FtsA/MreB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019910.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_09610"/>
    <dbReference type="EnsemblBacteria" id="AKH86646">
        <property type="protein sequence ID" value="AKH86646"/>
        <property type="gene ID" value="AA958_09610"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_09610"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2025"/>
    <dbReference type="OrthoDB" id="410781at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd10225">
        <property type="entry name" value="MreB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02207">
        <property type="entry name" value="MreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004753">
        <property type="entry name" value="MreB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01652">
        <property type="entry name" value="SHAPEPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00904">
        <property type="entry name" value="mreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0133">Cell shape</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="14"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="158"/>
            <end position="160"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="206"/>
            <end position="209"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="286"/>
            <end position="289"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH86646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="339" mass="36217" checksum="78FD283764956AD5" modified="2015-07-22" version="1">MSFIGRDMAVDLGTANTLVYVRGRGIVLNEPSVVAINTNTGGILAVGAEAKKMIGRTPGNIVAVRPLKDGVIADFEITERMLRYFILKIHKRRYLARPRVVVCVPSGITGVERRAVIEASTQAGARQVHIIEEPMAAAIGSGLPVHEATGNMVVDIGGGTTEVAVISLGGIVTAQSIRVAGDELDNAIIQHIKKEYSLLLGERTAENIKITIGSAYDTDRDEHTEIRGRDLVSGLPKTVVISSAEVRKAMEEPLNAIVDAVKTTLDKCPPELSGDIMDRGIVLTGGGALLAGLDERLRHETGMPIHLAEEPLDSVALGSGKCVEEFEALQQVLDAQPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NET7</accession>
    <name>A0A0F7NET7_9ACTN</name>
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        <submittedName>
            <fullName evidence="6">Pyridine nucleotide-disulfide oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_30660</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="2">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019081.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_30660"/>
    <dbReference type="EnsemblBacteria" id="AKH85853">
        <property type="protein sequence ID" value="AKH85853"/>
        <property type="gene ID" value="AA958_30660"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_30660"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6480"/>
    <dbReference type="OrthoDB" id="267896at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="5">
        <location>
            <begin position="9"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_dim" evidence="4">
        <location>
            <begin position="361"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="148"/>
            <end position="150"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="185"/>
            <end position="192"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="312"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="3">
        <location>
            <begin position="46"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH85853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="476" mass="49325" checksum="78536EE204BC3F20" modified="2015-07-22" version="1">MVKTESFAYDVVVIGGGPVGENVADRTRAAGLSTAVVESELVGGECSYWACMPSKALLRPVLASADARRLPGLSGLVAGGLDAAAVLARRDAFTSHWEDDGQVAWLDGIGADLYRGRGRLAGPRTVEVTDADGVVRTLTAGHAVAVCTGSRALLPRLPGLADVKPWTSREATSSAVVPGRLIVVGGGVVGVEMATAWQALGSRVTVLVRGGGLLDRMEPFAGELVTEALTEAGAQVRTGTSVTSVVRENGTVLATTDAGDTLEADEILFATGRAPRTDDIGLETVGLEPGSWLAVDDSLRVEGSEWLYGVGDVNHRALLTHQGKYQARIAGAAIAARAQGVPLLESDPWGAHAATADHGAVPQVVFADPEAAAVGMSLAEAERAGHRVRAVDADLGSVAGAGLYADGYRGRARMVVDVDEEILRGVTFVGPGVGELIHSATIAVAGEVPVSRLWHAVPSYPTISEVWLRLLEAYRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NEW5</accession>
    <name>A0A0F7NEW5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_30850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019111.1">
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH85883">
        <property type="protein sequence ID" value="AKH85883"/>
        <property type="gene ID" value="AA958_30850"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_30850"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6520"/>
    <dbReference type="OrthoDB" id="1352255at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025633">
        <property type="entry name" value="DUF4291"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38567">
        <property type="entry name" value="PTHR38567"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14124">
        <property type="entry name" value="DUF4291"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH85883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="198" mass="22585" checksum="16F0934CD60178DA" modified="2015-07-22" version="1">MTTEARQVRARQTADTVTVYQAYAPAVAGPALRAGTFVPPFKRERMTWIKPSFLWMMYRCGWAEKPGQERVLAVEISRRGFEWALRHSCLSHHDGRVYATREDWLAAKRTSPVRIQWDPERDTALRPLERRAIQIGLSGPAVGGYVEEWIRGIEDVTPLAREVRALLRERRREEAAALLPREEPCPLPDDVLARIGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFL3</accession>
    <name>A0A0F7NFL3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">XshC-Cox1-family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_28285</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018726.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_28285"/>
    <dbReference type="EnsemblBacteria" id="AKH85492">
        <property type="protein sequence ID" value="AKH85492"/>
        <property type="gene ID" value="AA958_28285"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_28285"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5962"/>
    <dbReference type="OrthoDB" id="1879870at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003777">
        <property type="entry name" value="XdhC_CoxI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027051">
        <property type="entry name" value="XdhC_Rossmann_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13478">
        <property type="entry name" value="XdhC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02625">
        <property type="entry name" value="XdhC_CoxI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XdhC_CoxI" evidence="1">
        <location>
            <begin position="11"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="XdhC_CoxI" evidence="1">
        <location>
            <begin position="114"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="XdhC_C" evidence="2">
        <location>
            <begin position="211"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH85492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="390" mass="39757" checksum="495901169063D93E" modified="2015-07-22" version="1">MLDIAADLARWCAEGRPFAVATVVGTSGSAPRGPGAALAVDAGGTAVGSVSGGCVEGAVYELCREVLETGEAVLETFGYSDDDAFAVGLTCGGEIDILVAPVSAGSVLRTALAAAAEGGAAAVARVVGGPAALLGQALLVRPDGTYDGRFAGPLPGLPDWDGAALERTAAAEAAALLDAGRTDTVSVGAAGARCGEPVTLLVEVSVPAPRMVVFGAIDFAHALVRIGKFLGYHVTLCDARPVFATARRFPEADEVAVRWPHEYLADALAAGELDGRTVLCVLTHDPKFDVPLLTAALRLPVAYVGAMGSRRTHLDRNRRLREAGVTDLELARLRSPIGLDLGARSPEEVAVSIAGEIVAARRGGTGVPLTGAHTPIHRERGAAGRIGDVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NGB2</accession>
    <name>A0A0F7NGB2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_01610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019711.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_01610"/>
    <dbReference type="EnsemblBacteria" id="AKH86489">
        <property type="protein sequence ID" value="AKH86489"/>
        <property type="gene ID" value="AA958_01610"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_01610"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.354"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="151"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="368"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH86489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="394" mass="43063" checksum="FC5DEAB79A035633" modified="2015-07-22" version="1">MDAVDVVARHLRRRFNATKVSFLIVDLTGKSVARLSTAGEAESGRETERIPLAGSVYEQVIRTQRLYQDACGREQRVIVPVTNRGDAIGLLELLLPTDLGEDVLAEIGDAAHILAYIVIANGRFTDFYTWGKRSRPPSLAAEIQYQLLPMSLSCEAAQFTLCGSLEPSEDLSGDTFDYALDRDTLHLSVTDPMGHNTDAALAATVLVGALRGARRAGADLAEQAGLADRALAEHGRGHATGHLLRINLRTGRARFVNAGHPWPLRLREGVVELITCEVDHPFGLFEPTPHPYRLQDMDLRPGDRLLVFTDGMLERHAEGVDLPTLLERTRDLHPREAALMLTSAVLDAAGGRLEDDATVMCLDWHGPQETQRHVSSGADTRQASAARTKPQPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NGJ6</accession>
    <name>A0A0F7NGJ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NmrA family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_30615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019075.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH85847">
        <property type="protein sequence ID" value="AKH85847"/>
        <property type="gene ID" value="AA958_30615"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_30615"/>
    <dbReference type="OrthoDB" id="1616572at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="9"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="309" mass="32172" checksum="C4BC46348F31937E" modified="2015-07-22" version="1">MSIVVTTPTGRVGSRVVRVLLQAGVRPRVLVRDPARLDPATRGLVDVRTGDMTDTAFVREATAGARTVFWVDPTQPTGPDPNAASERTAAGLVDAARAGDVARVVLLSSIGAELRGGAGHIDALGRIEECLDATGADTLHLRCAYFFSNLLFSLDDLARGVLPTQFHPERPMAWVDPRDIGDVAAARLLAGEWKGRVVQAVHGPEDLSFLQVAEILTGVLGRPVRAEAVSDADVRAALGSAGLPPGAVEAVAGMAAGTRDFTPEQPRDVLTTTPTTLAAWAYAHLRPRVSEAMRAAAARGGDGAAGAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NH25</accession>
    <name>A0A0F7NH25_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_31775</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019265.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_31775"/>
    <dbReference type="EnsemblBacteria" id="AKH86037">
        <property type="protein sequence ID" value="AKH86037"/>
        <property type="gene ID" value="AA958_31775"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_31775"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6710"/>
    <dbReference type="OrthoDB" id="990666at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="2"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH86037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="303" mass="32644" checksum="C3C2D5B8A1B91982" modified="2015-07-22" version="1">MIDLRRLRVLRAVAYYGTVTAAAESLHLTPSAASQQIRQLARELDVRLLEPQGRRVRLTPAARGLLAHADVIEAQWERAAAELHALGEEPAGELRMSGFPSAMCRLLAPVAGALRAAHPRLDVRLREAEPADCYDLLFDCETDLAVVEASAEAPARGDQRFEQHTLIEDPFDLVVPEDHPLAGRTAIELAEAAGERWIIGPPGVWSRQHVLAACSAAGFGPNVTHEACDWTVTAVMVSHGLGVALVPRLAQFSGVPSIRRLRITGVPVPSRTFLTVTRRGATGSPAVRAALDALQVRAKETVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NH30</accession>
    <name>A0A0F7NH30_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">3-oxoacyl-[acyl-carrier-protein] synthase 2</fullName>
            <ecNumber evidence="3 10">2.3.1.179</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">AA958_08190</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(9Z)-hexadecenoyl-[ACP] + H(+) + malonyl-[ACP] = 3-oxo-(11Z)-octadecenoyl-[ACP] + CO2 + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:55040"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10800"/>
            <dbReference type="Rhea" id="RHEA-COMP:14074"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:83989"/>
            <dbReference type="ChEBI" id="CHEBI:138538"/>
            <dbReference type="EC" id="2.3.1.179"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a fatty acyl-[ACP] + H(+) + malonyl-[ACP] = a 3-oxoacyl-[ACP] + CO2 + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:22836"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:14125"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:138651"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10 12">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.179" evidence="3 10"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019861.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_08190"/>
    <dbReference type="EnsemblBacteria" id="AKH86608">
        <property type="protein sequence ID" value="AKH86608"/>
        <property type="gene ID" value="AA958_08190"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_08190"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1728"/>
    <dbReference type="OrthoDB" id="606297at2"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00834">
        <property type="entry name" value="KAS_I_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017568">
        <property type="entry name" value="3-oxoacyl-ACP_synth-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000794">
        <property type="entry name" value="Beta-ketoacyl_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712">
        <property type="entry name" value="PTHR11712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000447">
        <property type="entry name" value="KAS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03150">
        <property type="entry name" value="fabF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10 14" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8 10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 12 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_KS" evidence="13">
        <location>
            <begin position="8"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR000447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000447-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AKH86608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="421" mass="43252" checksum="7B339D8914015AB5" modified="2015-07-22" version="1">MNATDRTVVVTGIGATTPLGGDSASTWDGLVAGRSGIADLAHDWAAELPVHFAGEVAVEPTEIIPRPQARKLDRAAQFALVATREAWADAGFTAKAGEDAAVDPDRLGAVVASGIGGVTTLLEQYDNLRDKGARRVSPHTVPMLMPNSPAANVGLQINARAGVHTPVSACASGGEAIGYAMEMIRTGRADVVVAGGTEAAIHPLPIAAFANMMAMSKKNDDPQGASRPYDKARDGFVLGEGAGVLVLESAEHAKRRGAKVYCEAVGQGLSADAHHIAQPEPSGRGIAAALENLFAHNDLTPAEVVHVNAHATSTPQGDVAEIKAMEKVFGDELGHVLVSGTKSMTGHLLGGAGGIESVAAVLAVKHRVAPPTINVEDLDDEVDPALIAVRATPLPAEGPIVALNNSFGFGGHNVVLAFRSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NH40</accession>
    <name>A0A0F7NH40_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MerR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_14185</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020045.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86754">
        <property type="protein sequence ID" value="AKH86754"/>
        <property type="gene ID" value="AA958_14185"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_14185"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2986"/>
    <dbReference type="OrthoDB" id="1748559at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00552">
        <property type="entry name" value="HTH_MERR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="79"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH86754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="115" mass="12913" checksum="2A7F4F2EAD173280" modified="2015-07-22" version="1">MRIGEVARRSGVSVRALRYYEEQGLLTPARSPGGQREYADDAVDRVRFFQQLYAAGLPSRRIAELLPCIDTGTTTGEQRAMLDAERARIRQQIDEYTAALARLDEIVEAAAERRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NHC8</accession>
    <name>A0A0F7NHC8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Galactokinase</fullName>
            <ecNumber evidence="11">2.7.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Galactose kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">galK</name>
        <name evidence="15" type="ORF">AA958_12085</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>alpha-D-galactose + ATP = ADP + alpha-D-galactose 1-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13553"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28061"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58336"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="11">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the GHMP kinase family. GalK subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.6" evidence="11"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019975.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_12085"/>
    <dbReference type="EnsemblBacteria" id="AKH86703">
        <property type="protein sequence ID" value="AKH86703"/>
        <property type="gene ID" value="AA958_12085"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_12085"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2543"/>
    <dbReference type="OrthoDB" id="1388391at2"/>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004335">
        <property type="term" value="F:galactokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00246">
        <property type="entry name" value="Galactokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000705">
        <property type="entry name" value="Galactokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022963">
        <property type="entry name" value="Galactokinase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019741">
        <property type="entry name" value="Galactokinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019539">
        <property type="entry name" value="GalKase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006203">
        <property type="entry name" value="GHMP_knse_ATP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006206">
        <property type="entry name" value="Mevalonate/galactokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10457:SF6">
        <property type="entry name" value="PTHR10457:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10509">
        <property type="entry name" value="GalKase_gal_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000530">
        <property type="entry name" value="Galactokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00473">
        <property type="entry name" value="GALCTOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="SSF55060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00131">
        <property type="entry name" value="gal_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00106">
        <property type="entry name" value="GALACTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00627">
        <property type="entry name" value="GHMP_KINASES_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-0299">Galactose metabolism</keyword>
    <keyword evidence="6 11 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GalKase_gal_bdg" evidence="14">
        <location>
            <begin position="12"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP_kinases_N" evidence="12">
        <location>
            <begin position="134"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP_kinases_C" evidence="13">
        <location>
            <begin position="305"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="11">
        <location>
            <begin position="36"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="144"/>
            <end position="150"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="11">
        <location>
            <position position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF10509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AKH86703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="405" mass="42039" checksum="82E0002E391CBFB8" modified="2015-07-22" version="1">METGAAETAAAAFAELYGERPAGVWAAPGRVNLIGEHTDYNDGFVMPLALPHTTLAAARRRDDGVLRLHSGDGESRLTELAVDRIAPPPHLAEPGRAVPPAVGGDRGGWAAYPAGVVWALRRTVDAFADFAGADIHYESTVPTGAGLSSSAALEVSTALALSDLYGLGLDPVQLAKVSQHAENDFVGVPSGIMDQMASACCTAGHLLHLDTRDLTQRAVPFDLAAGGLTLLVVDTQVKHALGDGEYAERRAGCEAAARALGVPALRDVPYAELDAALARLTDPAVRPLVRHVVTEDRRVEECITLLDAGRTRDIGPVLLAGHASLRDDFRVSCRELDVVVESSVAAGALGARMTGGGFGGSAIVLAETDAADTVGKAVESAFAAADFRPPRIFTAVPGAGARRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NHE4</accession>
    <name>A0A0F7NHE4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_17395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="match status" value="1"/>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NHF9</accession>
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    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86177">
        <property type="protein sequence ID" value="AKH86177"/>
        <property type="gene ID" value="AA958_32600"/>
    </dbReference>
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    <dbReference type="PATRIC" id="fig|444103.5.peg.6886"/>
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    <dbReference type="Proteomes" id="UP000034283">
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        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
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        <property type="project" value="InterPro"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Transposase_11"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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            <end position="94"/>
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    </feature>
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            <begin position="101"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH86177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="256" mass="28322" checksum="D81CB95B19572A0A" modified="2015-07-22" version="1">MSGVITASEPAWIAPFTGLSPRQFGKLITALRREGADPVRKGRPWSLPLEDRVLLVAAYWRTNLTLRQLAPLFGVSKSAADRIIDHLGPALALQPRRRFRKDAVLIVDGTLVPTRDHTIAEQSKNYRYSTNHQVVIDTDTRLVVAVGRPVAGNRNDCKAWELSGAKDAVGKTTVIADGGYRGTGLVIPHRRGKGQTELPDWKEEHNASHRKVRARAEHAFARMKGWKILRDCRLKGDGVHHAVLGIARLHNLVLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NJ39</accession>
    <name>A0A0F7NJ39_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AA958_16135</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_16135"/>
    <dbReference type="EnsemblBacteria" id="AKH86817">
        <property type="protein sequence ID" value="AKH86817"/>
        <property type="gene ID" value="AA958_16135"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_16135"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3400"/>
    <dbReference type="OrthoDB" id="749401at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13123">
        <property type="entry name" value="MATE_MurJ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004268">
        <property type="entry name" value="MurJ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03023">
        <property type="entry name" value="MurJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01806">
        <property type="entry name" value="VIRFACTRMVIN"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01695">
        <property type="entry name" value="murJ_mviN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0133">Cell shape</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="405"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="433"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="476"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="519"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="554"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="591"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="638"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="681"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="726"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="759"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="793"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="820"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="861"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="894"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="360"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="101"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="128"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="365"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AKH86817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="933" mass="98930" checksum="AE67A326ABAA881B" modified="2015-07-22" version="1">MNAPYDGDRSQGTGDPANLPPAGSPPPAHPQSPADQQNADPYAPDPYAQPLQDPYAQYPQEHYAPPAADPYGQGGPGHYGHPAAADPYAQHPPQAHPGTQDPYAQPGQQGQHAQPGQHGGQPHYGQPQPPQHGGPPQQAHPDQYGPPTPPAYQGQPGGQHAPDPYGRQGQDPYGRPADPYAAGPQPSAPQAPHDPRSPYQQSDPRAPHYPQQPHHPQGGQPQHPHADPRDPYAQTAAQGAPGPSAPYSHDPYLQDAYAPDPYQQRADPLGDAFYDHAAHPPPPAGSRPAAQPPYQQPPSPHYRTDPRQWADPPAPEPDGPTRHLRYGDETTQFVGMDDLVTGAGRPAQPEPDAFAHLFRDQRAPQPPPGLQPQPAAAPAPVPPQRRGGRVASLARSSAVMAAGTLVSRITGFLRTLVISAALGVAVLGDTYTVAYTLPTMIYILTIGGGLNSVFVPQLVRAMKNDPDGGIAYANRLLTLVSVILGGMVLIAVFAAPLLIRAMSVKIADNPHSNEVAITFAQYCLPTIFFMGIHVVMGQILNARGSFGPMMWTPVLNNIVIIATFGLFLWVYGTSDSSAMDETTIPAEGVRLLGVGTLLGLVVQSLAMIPYLRQTGFRIRPRFDWKGHGLGKAAKLAKWTFLFVLANQAGMLVVTQLATWAGESAAEVGHKGTGIMAFQNALLIWQMPQAIITVSVMAAMLPRISRAASDGDPNAVRDDISHGLRTSAVAIVPIAFALVALGIPMCTLLFAAVGSDAATSIGYVLMAFGLGLIPFSVQYVVLRGFYAYEDTRTPFYNTLIVAAVFATGSAISFLLLPDRHAVIGMAACYGVAYVVGVGVAWRRLKQRMGTNDLDGAHVVRTYARLIGASIPAALAGGAAAWAVTDKLGEGVTGSLAALVVGSLVLGAIFYVAARRMRIQELNAMMGMVRGRLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NK28</accession>
    <name>A0A0F7NK28_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH-quinone oxidoreductase subunit N</fullName>
            <ecNumber evidence="5">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">NADH dehydrogenase I subunit N</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">NDH-1 subunit N</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nuoN</name>
        <name evidence="8" type="ORF">AA958_30475</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the complex I subunit 2 family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020569.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_30475"/>
    <dbReference type="EnsemblBacteria" id="AKH87147">
        <property type="protein sequence ID" value="AKH87147"/>
        <property type="gene ID" value="AA958_30475"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_30475"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6440"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00445">
        <property type="entry name" value="NDH1_NuoN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010096">
        <property type="entry name" value="NADH-Q_OxRdtase_suN/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0874">Quinone</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="154"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="268"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="293"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="323"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="355"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="396"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="437"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="7">
        <location>
            <begin position="121"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH87147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="469" mass="47277" checksum="6B17E83CD267335D" modified="2015-07-22" version="1">MDENPLDLLPEVLLAGSAVLGLLLGAWLPRRRQWLVGALGLAACTAGIAAAAVAAGGGPMAAFDGAFAVDTVTSAGRIVILAGTVTVLLLGFAPFRGDARESEFHVLVQLAALGALMLAGAQDLLLLAAAYLLASVPSYTLAGFRRDAPGTEAALKYFVTGALLGVVMLAGITVLYAAGRASAYPALGDALPGAPAVLVTAGTVGLLAGLLFKTGAVPGHFWVPDAVEGSSAPAAALLTTLPKVGALAALHRLAAVPLAGTDVPWDELVAVLAAASMTLGNLAAFFQTDVKRLLAYSTVSQVGYLLLPVAVATRADGAQRALLFYLAGYAVTNLGAFAVVCALPHARTLADYRGLLRAHPGLALSLAVCLLGLLGTPPTAVFLGKLEVLTAAVDGGYLWLAVLAAVNTVASLFYYLRWIRPAFAAAAGSGPRPLVRPAALTAYAAAAVSVALGVAAGPVLDLLGGPLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MX94</accession>
    <name>A0A0F7MX94_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_00175</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH80845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014212.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_00175"/>
    <dbReference type="EnsemblBacteria" id="AKH80845">
        <property type="protein sequence ID" value="AKH80845"/>
        <property type="gene ID" value="AA958_00175"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_00175"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.40"/>
    <dbReference type="OrthoDB" id="1290092at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH80845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="191" mass="21404" checksum="C4880884025F787C" modified="2015-07-22" version="1">MAGRWQQFGDYGADGVPGKQALARQLDELLTGITTPVDTDRGLHARLRYLTASAAGYEAMSRAGISVTGRTLMRWLAEEARPTPANLHRIDAAYWDLRRRNVAHDLKRRLNNHGRGTRMEIYPVDQQGVTPARRRDLSVRDINVRRVWDDMVDAWRDGDEAALDGIWDTIISDLGSAYDAYSYVTAVGFGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MXX2</accession>
    <name>A0A0F7MXX2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Leucine-rich repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_01715</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014459.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_01715"/>
    <dbReference type="EnsemblBacteria" id="AKH81095">
        <property type="protein sequence ID" value="AKH81095"/>
        <property type="gene ID" value="AA958_01715"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_01715"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.375"/>
    <dbReference type="OrthoDB" id="807134at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH81095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="238" mass="25853" checksum="EDA39344D59222FC" modified="2015-07-22" version="1">MNLWRAGLSAVPPQVWQETDAEVLVLAENALTHVPDDIAALTRLHTLDLGHNALVAVPEAIGELTALSGCLYLHHNHLTVLPAALGRLHALGYLNVGSNPLRALPEEVGDMAGLVELRAQECGTSGLAFLPESIGRLSALRELWLRGNALGSLPDSVADLGELRELELRENALPEVPEVLAELPMLRRLDLRANKIRDIPPWVAHMPALEKLDLRWNEVAGTEAPLVALRERGCVVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MYS5</accession>
    <name>A0A0F7MYS5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pyridine nucleotide-disulfide oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_00480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH80891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014257.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_00480"/>
    <dbReference type="EnsemblBacteria" id="AKH80891">
        <property type="protein sequence ID" value="AKH80891"/>
        <property type="gene ID" value="AA958_00480"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_00480"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.112"/>
    <dbReference type="OrthoDB" id="912110at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="1">
        <location>
            <begin position="11"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH80891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="417" mass="44307" checksum="F78FDFED08210AC9" modified="2015-07-22" version="1">MTHQPPLTTTDVLVIGAGPAGLTAAADLAAGRAGEVLVVDREPAAGGIPRHSDHTGYGLRDLHRVLSGPAYARRLVDRAAAAGAGIRTRTTVTGWADAATVEITSPEGRYRIRARAIVLATGARERPRTARRIPGDRPEGVLTTGQLQNLVHLHHRPVGRRAVIVGGEPVSWSAALTLREAGCTPALMVSEHPKAESYAAFNAAGRTVLRVPVATRTRVTRVIGKNRCEAVEIEHLDTGRRRTVACDTVVFTGDWIPDHELARAAGLTLDPGTLGPLTDTALRTSSPGVFAAGNLLHPVDTADIAALDGRHVAAQVRRHLDGECRSAEGVRLIADAPFRWIAPQVLRPGDPAPPSGRLLLWTDTFVRFPRITVRQDSGTVTTRRLPWPAAPGRAFRIPSALLDGVSPAGGPVHIGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MYY9</accession>
    <name>A0A0F7MYY9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Proteasome subunit beta</fullName>
            <ecNumber evidence="3">3.4.25.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">20S proteasome beta subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Proteasome core protein PrcB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">prcB</name>
        <name evidence="5" type="ORF">AA958_04000</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>Cleavage of peptide bonds with very broad specificity.</text>
            <dbReference type="EC" id="3.4.25.1"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="3">The formation of the proteasomal ATPase ARC-20S proteasome complex, likely via the docking of the C-termini of ARC into the intersubunit pockets in the alpha-rings, may trigger opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein degradation; proteasomal Pup-dependent pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped by the proteasome-associated ATPase, ARC.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase T1B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.25.1" evidence="3"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014846.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_04000"/>
    <dbReference type="EnsemblBacteria" id="AKH81490">
        <property type="protein sequence ID" value="AKH81490"/>
        <property type="gene ID" value="AA958_04000"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_04000"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.839"/>
    <dbReference type="OrthoDB" id="1129370at2"/>
    <dbReference type="UniPathway" id="UPA00997"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019941">
        <property type="term" value="P:modification-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02113_B">
        <property type="entry name" value="Proteasome_B_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000243">
        <property type="entry name" value="Pept_T1A_subB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022483">
        <property type="entry name" value="PSB_actinobac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00141">
        <property type="entry name" value="PROTEASOME"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03690">
        <property type="entry name" value="20S_bact_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0645">Protease</keyword>
    <keyword evidence="3 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0888">Threonine protease</keyword>
    <keyword evidence="3" id="KW-0865">Zymogen</keyword>
    <feature type="propeptide" id="PRO_5005028052" description="Removed in mature form; by autocatalysis" evidence="3">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023495859" description="Proteasome subunit beta" evidence="3">
        <location>
            <begin position="54"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3 4">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600243-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH81490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="281" mass="29800" checksum="3CCA48B3BD006388" modified="2015-07-22" version="1">MEANIRGAGRLPAAFLTPGSSSFMDFLGEHAPAALPGNREVPPVKGAVEAPHGTTIVALTFPGGVVLAGDRRATMGNMIAQRDIEKVFPADEYSAIGIAGTAGVAVEMVRLFQLELEHFEKVEGAQLSLEGKANRLSTMIRSNLGMAMQGLAVLPLFAGWDPAREKGRIFSYDVTGGRTEERGFASVGSGSVFARGALKKLFTDELTERQAATVVVQALYDAADDDSATGGPDLTRRIFPIVTSITDEGFRRLPDAEVSEIARSVVDGRLELPDGPRASVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MZ01</accession>
    <name>A0A0F7MZ01_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AA958_00830</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH80951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014317.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_00830"/>
    <dbReference type="EnsemblBacteria" id="AKH80951">
        <property type="protein sequence ID" value="AKH80951"/>
        <property type="gene ID" value="AA958_00830"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_00830"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.186"/>
    <dbReference type="OrthoDB" id="760677at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="9"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="126"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="258"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH80951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="408" mass="44228" checksum="FA323A19FFF530C3" modified="2015-07-22" version="1">MSEFTFELNEDQRSVQEWVHGFAADVIRPAAAEWDEREETPWPVIQEAAKIGLYSLDFYAQQYFDPTGLSIPMVMEELFWGDAGIALSIVGTGLAAVGVLANGTEEQIGTWIPQMYGDVDNVQLAAFCSSEPDAGSDVSAMRTRAVYDEAKDEWVLNGTKTWATNGGIAAVHVVVAVVDPELGTKGHASFIVPPGTPGLSQGQKFKKHGIRASHTAEVVLEDVRVPGSCLLGGRDRLQERLARARERAKSGGERVKNAAMATFEASRPAVGAQAVGIARAAYETALEYAKTRVQFGRPIIDNQGVAFQLADMRTQIDAARLLVWRASWMASAGKGFTSAEGSMSKLYAGEVAKDVTARAMQILGGNGFTREYPVERMHRDAAIYTIFEGTSEIQRLVIARTLAGVPIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MZ68</accession>
    <name>A0A0F7MZ68_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tat pathway signal sequence domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_01265</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="PTM">
        <text evidence="1">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014386.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_01265"/>
    <dbReference type="EnsemblBacteria" id="AKH81021">
        <property type="protein sequence ID" value="AKH81021"/>
        <property type="gene ID" value="AA958_01265"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_01265"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.278"/>
    <dbReference type="OrthoDB" id="1067869at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018905">
        <property type="entry name" value="A-galactase_NEW3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013222">
        <property type="entry name" value="Glyco_hyd_98_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038637">
        <property type="entry name" value="NPCBM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08305">
        <property type="entry name" value="NPCBM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10633">
        <property type="entry name" value="NPCBM_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00776">
        <property type="entry name" value="NPCBM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002518959" evidence="2">
        <location>
            <begin position="27"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="domain" description="NPCBM" evidence="3">
        <location>
            <begin position="590"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="1">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600917-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH81021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="738" mass="78582" checksum="28D460BEA92EC5AF" modified="2015-07-22" version="1">MSSRRHFLAGSAALGLAALPPGSARAEGRSPAAQGGGGRPNVVVILADDLGYGGVGAYGQRLVRTPRLDRLAAEGLRFTQAYSAAAVCAPSRCAALTGVHAGHARVRENPFGGPQGSLTADDTTFAEVLQGRGYRTACIGKWGFGPEEADQPSHPNARGFTDFYGYITHGHAHQYYPQYLWHNGAQEQIPENADGARGAFVIDLLQERAVSFLDAHAGEPFLLMLNPNVPHAPSDIPDQGEYADRPWSEADKGHAAQITRLDALVGAVVDALVRLGVHRDTLLLFSSDNGPHEEGGVDPDLFDENGPLRGYKRNLYEGGVRVPLIAWRPGTVRPGVSERPTPLTDLLPTLAEVAGAPAPRDLDGLSAASLLAARPAPAPVHHHLYWYRNDPGSTKRANAVDGGRILRLAESVRRRDWKAVRFAPGRDREVPDAAWDFELYDLAADPGETRDVAAECPGVVAELTGLLRSSWAGEYERERFGTRIESPEIAYPGEPFTVTATLANGSDRAWTDAGIRLYAPAGWRLRPAGPARAAVLPPGDVLRTAVEVTPARGDAAAGPRLLRAEGTAAYGRAALRYPESRTVAVPPPAPRRDSFLSDLEWVSASNGWGPVERDRSNGRQAAGDGTPIGFGGVTYAKGLGVHAPSEIVYHLGAVATRMTAVVGIDDFSASQSANGATAAQVWGDDRLLYESGTLTPATGPREVDVDVTGVRLLRLVVRDANGSTSYDHTSWAAAHVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MZ73</accession>
    <name>A0A0F7MZ73_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_04590</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014945.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_04590"/>
    <dbReference type="EnsemblBacteria" id="AKH81590">
        <property type="protein sequence ID" value="AKH81590"/>
        <property type="gene ID" value="AA958_04590"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_04590"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.968"/>
    <dbReference type="OrthoDB" id="1859760at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="3">
        <location>
            <begin position="11"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH81590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="362" mass="35893" checksum="CFBA43BDF39686F5" modified="2015-07-22" version="1">MTRAAVLPAIGSPLELADIDLPAPGAGHVRVRLAAAGVCHSDLSLANGTLRQPVPAVLGHEGAGTVVAVGEGVTGVAVGDEVVLNWAPSCGACHYCGLGEPWLCAAAGAAAAEPYATRDGAGLYPGLGTAAFAEETVVPARAVLPLPAGVPLADAALLGCAVLTGWGAVHHAAAVRAGESVAVFGAGGVGLAVLQAARIAGAGPLVAVDVSPAKEELARAAGATDFVLAAPGGERDTAKRIRTLTAGIGADVAIECAGRAESIRTAWSSTRRGGRTTVVGIGGQEERVSFSALELFYFGRTLSGCVYGNSDPARDLPAIAAHVRTGELDLGGLVTARIGLDGIPAAFDAMLAGRGGRALVLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MZM6</accession>
    <name>A0A0F7MZM6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_05600</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015114.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_05600"/>
    <dbReference type="EnsemblBacteria" id="AKH81760">
        <property type="protein sequence ID" value="AKH81760"/>
        <property type="gene ID" value="AA958_05600"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_05600"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1173"/>
    <dbReference type="OrthoDB" id="1926714at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="10"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="42"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH81760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="311" mass="33152" checksum="9AC52A009BD71BE4" modified="2015-07-22" version="1">MQQPSTDAAVAVSGLVKRYGGKTAVAGLDLTAARADVTAVLGPNGAGKTTTVEICEGYRRPDAGTVRVLGRDPLADAAELRPRVGVMLQSGGVYPAARAEEMLRHVARLHAHPLDVVALIERLGLGSCGRTPYRRLSGGQQQRLALAMAVVGRPELVFLDEPTAGLDPQARRATWELIRELRADGVSVVLTTHHMDEAEQLSDKVAIIDGGRLLVEGAPDELCRGGAENTMRFTGRAGLDLGSLLKALPAETAALELVPGSYRITGEINPELLATVTTWCAQNGVLPEQMTVERRTLEDVFLELTGKDLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0Q4</accession>
    <name>A0A0F7N0Q4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PucR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_08170</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CdaR family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_08170"/>
    <dbReference type="EnsemblBacteria" id="AKH82210">
        <property type="protein sequence ID" value="AKH82210"/>
        <property type="gene ID" value="AA958_08170"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_08170"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1724"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041522">
        <property type="entry name" value="CdaR_GGDEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17853">
        <property type="entry name" value="GGDEF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGDEF_2" evidence="3">
        <location>
            <begin position="160"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_30" evidence="2">
        <location>
            <begin position="319"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH82210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="387" mass="41208" checksum="8618617AA650F21E" modified="2015-07-22" version="1">MQHPHTATLRRLEKSSGELAAAAIARMDEQLPWYRAMPPEHRSWIGLVAQAGIAAFTEWFRHPETPQAISTDVFGTAPRELTRAITLRQTVEMVRTTIEVMESAIEDVAAPGDESALREALLVYAREIAFATAQVYAQAAEARGAWDARLESLVVNAVLSGEADEGAVSRAAALGWSSPDHVCVVLGTAPDGDSELTVEAIRRAARHAKLQVLTGVLGTRLVVIAGGSAEPLKAAKALIGPFAQGPVVAGPVVGDLLAATRSAQAAAAGLKACSAWEDAPRPVLADDLLPERAIAGDPAAREQLVEEIYSPLAEAGSALLETLSVYLEQASSLEGAARMLFVHPNTVRYRLRRVTDVTGWSPSDVRSAFTLRIALILGRLTETEPQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N190</accession>
    <name>A0A0F7N190_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_02205</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014542.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_02205"/>
    <dbReference type="EnsemblBacteria" id="AKH81178">
        <property type="protein sequence ID" value="AKH81178"/>
        <property type="gene ID" value="AA958_02205"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_02205"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.474"/>
    <dbReference type="OrthoDB" id="1254678at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="264"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="287"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="312"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH81178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="346" mass="35715" checksum="9F13919C3BFF045F" modified="2015-07-22" version="1">MSATVQKTEPAPAGGDERSARSVTDMIFRARELSIGGALVLLILCTWIANPSFLDDQGVKDLLLNSSILVLLAVGQSVVVITRNIDLSVGSVVGLTAFACGDFVSGTDHSAFTVVLLGIALGTACGLVSGLLVSFGKVPALVVTLGMLYVIQGLDYWWAGGEQINAANLPDDVLSLGTGSLLGIPYLPLITAAVLAATAYYLRAYTGGRELYAIGSNPEAARLAGIPIRRRVLGAYAFSGAIAGFAGALWLARFGTVVADAANGWELTVVSAVVVGGVAITGGVGSVWGAALGAALLTTIGSALVVLKVSSFWQQAITGVLLLAAITTDRIVQRRTTSALRKRRRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N1F5</accession>
    <name>A0A0F7N1F5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amino acid decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_06035</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the group II decarboxylase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015189.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_06035"/>
    <dbReference type="EnsemblBacteria" id="AKH81836">
        <property type="protein sequence ID" value="AKH81836"/>
        <property type="gene ID" value="AA958_06035"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_06035"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1261"/>
    <dbReference type="OrthoDB" id="1478871at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016830">
        <property type="term" value="F:carbon-carbon lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="465"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3">
        <location>
            <position position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH81836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="485" mass="49095" checksum="9248C56832956300" modified="2015-07-22" version="1">MPAAAEAALAGGPAGPRALRPYLDTVLAALGDGADRRRGPLPAGGPAAVAARVRAAVRPVLPDTGVGAEAALAGLVRLLAEGAADPADPHCAAHLHAPPLAVAAAADLAAGALNPSLDSWDQAPAAAELEAEVAAAVAAEVHPGAARPDALVTTGGTEANQLALLLARELLGPGVQVVAGAGAHHSVRRAAWLLGMRAPHAVPTPRGVLDPAAVRDVLAEIRGPGGAPGPALVVATAGTTDAGAVDPLPALADAAAAHGARLHVDAAYGGLLLLAPARAHLVAGLDRAHTVALDLHKLGWQPIAAGFLAVRDDADLAPLAYTADYLSADDDTDAGLPALLHRSLRTTRRADVLKIAVTLRALGRAGIAELVERTFTAAAHLAELVEEDPELELYAPPTLTTVLFRPAGAGDAAVGALRRRLLTDGHAVLGRAEAGGRRWLKATLLNPHVHPGDLRNLLKLVTEAHRAPALTPRQERENGAASDAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N1G4</accession>
    <name>A0A0F7N1G4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Chaperone protein DnaJ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">dnaJ</name>
        <name evidence="11" type="ORF">AA958_09350</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 2 Zn(2+) ions per monomer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="6">The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DnaJ family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015746.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_09350"/>
    <dbReference type="EnsemblBacteria" id="AKH82400">
        <property type="protein sequence ID" value="AKH82400"/>
        <property type="gene ID" value="AA958_09350"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_09350"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1973"/>
    <dbReference type="OrthoDB" id="1738789at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01152">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012724">
        <property type="entry name" value="DnaJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
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    </dbReference>
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        </location>
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            <label>1</label>
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        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="377" mass="40582" checksum="AF283A1A19F26791" modified="2015-07-22" version="1">MATDYYAVLGVGRDASQEEIKKAFRRLARELHPDVNPDPKTQERFKEINAAYEVLSDPQKKQIYDLGGDPLSQNGAAAGGFGAGGFGNLSDIMDAFFGQAGQRGPRSRTRRGQDAMIRLEIELEEAAFGATKEIQVDTAVVCGTCNGEGAAPGTSAQTCDMCRGRGEVSQVTRSFLGQVMTSRPCPQCQGFGTVVPTPCPECAGDGRVRSRRTLTVKIPAGVDTGTRIQHAGEGEVGPGGGPAGDLYVEIRELPHPIFQRRGDDLHCTVTIPMTAASLGTKVNLETLDGLEEVDIRPGTQSGQSIPLHQRGVTHLRGGGRGDLVVHVEVETPQKLDPEQERLLRQLAQLRGEERPQGQFKPGQQGLFSRLKDAWSGR</sequence>
</entry>
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        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
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        <location>
            <begin position="17"/>
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        <location>
            <begin position="68"/>
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        </location>
    </feature>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF13462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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    </evidence>
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    </evidence>
    <sequence length="242" mass="25926" checksum="797DABC7C381FD8F" modified="2015-07-22" version="1">MQAERERQRSMDKRRRMLVVLAAVVGVLAVVAVVGVLIGQNSGSDTNDKPVVFPKGAVGEDRLALPAGRAAAPAALTVYEDFRCPACGQFEDRFSKTINELEDAGKLRTEYRLVKLIDGNFGGTGSLNSANAAACAQDAGKFVPYHDVLFRNQPPENDDAFAEKGHLKDLAGKVDGLRGKRFDSCVDDGRFDGWVDASDEAFGKSGHNSTPTVLLEGENILGPGSNLTPESFKQLVEDAGKD</sequence>
</entry>
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    <accession>A0A0F7N204</accession>
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            <authorList>
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="202"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="233" mass="25940" checksum="0597B4E17F065E93" modified="2015-07-22" version="1">MTTSSPTPTTARWDAYEPGLAGRTVRACLEPIQRGYVSNDEPWAVARLAQLRRGAGKAPEEVPELFGLIDMDALYTPEGRVRGSEHGPTAIHLAVTLYALHQQSQRASRMHVIGPQLGGAVRALMPQGEIDEPLRRRFVRAAGATSANVLAYRLRELILLLRRAGEPLDYGRLADQIERILDPTRRLAVRREWGRDFHSWRPRKDAEGVHPTNEGGSPATGHDSEDTREPYGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N225</accession>
    <name>A0A0F7N225_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AA958_00630</name>
    </gene>
    <organism evidence="10 11">
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        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNQ-509</strain>
        </source>
    </reference>
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    <dbReference type="EnsemblBacteria" id="AKH80917">
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        <property type="gene ID" value="AA958_00630"/>
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    <dbReference type="KEGG" id="strc:AA958_00630"/>
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    </dbReference>
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        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901362">
        <property type="term" value="P:organic cyclic compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
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        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
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        <property type="entry name" value="ADH_N"/>
    </dbReference>
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        <property type="entry name" value="GroES-like_sf"/>
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        <property type="entry name" value="Ketoacyl_synth_AS"/>
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        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
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        <property type="entry name" value="Ketoacyl_synth_N"/>
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    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
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    <keyword evidence="1 7" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
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    <keyword evidence="3" id="KW-0808">Transferase</keyword>
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        </location>
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            <end position="2791"/>
        </location>
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            <end position="4860"/>
        </location>
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            <end position="955"/>
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        <source>
            <dbReference type="PROSITE" id="PS50075"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="AKH80917.1"/>
        </source>
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        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
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    <sequence length="4949" mass="515642" checksum="204037FB34400F9B" modified="2015-07-22" version="1">[encoded data, 4949 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2J9</accession>
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        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
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                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">CNQ-509</strain>
        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
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        </subcellularLocation>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="312"/>
        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH81177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="327" mass="33529" checksum="8FD9A3E1202941B7" modified="2015-07-22" version="1">MKSLGTYLRWDTAVGILLIAVFLAGTSSTDGFASTGNMSAALNDTAEIALIALPMTLLVVAGQVDLSVASMLGLSSALAGSLWDAGYAFELIVPVCLLAGAAGGLLNGWLVTRVGLPPLAVTIGTLTLYRGLASVVLGDKAVAGFPDTYSQWASSTETVPGTFVPYPIALFAVLAVLAAVLLHMTGFGRSLYAIGAQEDAAWFAGIRVKRIKLALFVVSGLMASFAGIVYTLRYGSARADNGLGLELVVIASVLLGGVDFNGGKGTLGGAVAGVLLIGLLNNLLTLNDVANEIRVIVTGLLLIASVLAPRAISTLAERRNRRLAAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N317</accession>
    <name>A0A0F7N317_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Endoribonuclease YbeY</fullName>
            <ecNumber evidence="7">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ybeY</name>
        <name evidence="8" type="ORF">AA958_09290</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the endoribonuclease YbeY family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="7"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015737.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_09290"/>
    <dbReference type="EnsemblBacteria" id="AKH82391">
        <property type="protein sequence ID" value="AKH82391"/>
        <property type="gene ID" value="AA958_09290"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_09290"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1960"/>
    <dbReference type="OrthoDB" id="1830156at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00009">
        <property type="entry name" value="Endoribonucl_YbeY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023091">
        <property type="entry name" value="MetalPrtase_cat_dom_sf_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002036">
        <property type="entry name" value="YbeY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020549">
        <property type="entry name" value="YbeY_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46986">
        <property type="entry name" value="PTHR46986"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02130">
        <property type="entry name" value="YbeY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00043">
        <property type="entry name" value="TIGR00043"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01306">
        <property type="entry name" value="UPF0054"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6 7" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH82391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="165" mass="18023" checksum="846C3190FEF8BC70" modified="2015-07-22" version="1">MSVEVNNESGVEADEEAVLGVARYALARMRIHPLSELSVILVDPAAMEQLHVQWMDEPGPTDVMSFPMDELRPPAKDDEEPVQGLLGDIVLCPEVARRQGAAAPTGHSMDEELQLLTVHGVLHLLGYEHEEPAEKAEMFGLQKAIVDGWRAERGVTGPSPAPTER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N371</accession>
    <name>A0A0F7N371_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SLT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_02935</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014665.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_02935"/>
    <dbReference type="EnsemblBacteria" id="AKH81302">
        <property type="protein sequence ID" value="AKH81302"/>
        <property type="gene ID" value="AA958_02935"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_02935"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.627"/>
    <dbReference type="OrthoDB" id="1891666at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008258">
        <property type="entry name" value="Transglycosylase_SLT_dom_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01464">
        <property type="entry name" value="SLT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519004" description="SLT domain-containing protein" evidence="2">
        <location>
            <begin position="41"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="SLT" evidence="3">
        <location>
            <begin position="123"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH81302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="197" mass="20115" checksum="893020C58C06ADAC" modified="2015-07-22" version="1">MSAPTLLRPAAARRRLLAAGGWAAAAVALTGAVAPQAVAAAPQSAAPASAHASAPSKPAASSKPSAPAKPAAPAKPSAPSSSSSSPVHATKGTNLDEWIKQAMDVMERHDIPGTYEGIHRNIIRESSGDPQAVNNWDINAVNGVPSQGLLQVIPPTFDAYHVPGTTKNIVDPVANIVAACNYAADRYGSIDNVWGAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N373</accession>
    <name>A0A0F7N373_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_09700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015799.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_09700"/>
    <dbReference type="EnsemblBacteria" id="AKH82456">
        <property type="protein sequence ID" value="AKH82456"/>
        <property type="gene ID" value="AA958_09700"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_09700"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2041"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="170"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH82456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="380" mass="40428" checksum="52C839C9094A2994" modified="2015-07-22" version="1">MAGGAGSTSQAARWHKTLHRVRVGVRRAGVDYFRGEGSDWIALVVLLLTIPALAAGTLFSPAWVSPAALVLPIFIGGLVLRPASLLALYAASATALIVEAMLLGPYAEGPARVTPGTVLVIASVGLTGLTVAQFRSRVGVPWRRGGTMLFDLRERIRVQSKLPRLPRGWHAEMSLRPAGGQSFSGDFVVASRTHGGQILEAVLTDVSGKGMAAGSRALLLSGAFGGLLGSLPPHDFLPAANGYLLRQEWQEGFATSVHLVLDLESGDYELFSAGHVPGVQLSAGTGRWEEKGAEGPLLGVVEEAQFDPLKGTLRRGDVLMLFSDGLVEAPDRDLTEGMDRLIGEADHYASSTFRGAAWHLIEKVAKDVKDDRALLLICRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3J5</accession>
    <name>A0A0F7N3J5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_06715</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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            <end position="207"/>
        </location>
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        <location>
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        </location>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH81954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="226" mass="22406" checksum="ACEDF9643E360BDD" modified="2015-07-22" version="1">MAERNPDREDPQQGDGPAETEPAGAEPAGSGGAPLDEEAAWAEIVAAFDEDSVEPPHERAARAAAEGEGPAGGAEGGPADAGGGVATAEGPADPDEDGGPGAAAKSGGTGGGDGASFIVFSAGTGPRDWEAAEASDDDLDETDEGHFVPPEPPPLPKADTTTKFAWLAVLGGPLLLLGMLIFQQPMTWWASVLGIGGFLGGFATLVARMRPGGDDDDEPPGGGAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N408</accession>
    <name>A0A0F7N408_9ACTN</name>
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        </submittedName>
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    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
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        <lineage>
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        </lineage>
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    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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        <property type="gene ID" value="AA958_04550"/>
    </dbReference>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="project" value="UniProt"/>
    </dbReference>
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        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="KstR2_TetR_C"/>
    </dbReference>
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        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <location>
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        </location>
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    <feature type="DNA-binding region" description="H-T-H motif" evidence="4">
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            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH81582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="214" mass="22984" checksum="563CA832B6DEF3AE" modified="2015-07-22" version="1">MQDVQDPAAWGGVEPEAAQRLLTAGVEAFAERGYHATTTRDIAGRAGMSPAALYIHFKTKEELLFRISRVGHERARAIIAAAAESGGPAGERLARAVRAFARWHAEHHTTARVVQYELAALGEEHYAEIVALRRDIDRLVRGIIEDGVRDGEFAVADVPGTALAVLSLCVDVARWFSASGSRPPEELAALYADLVGRMVAAPAAPPAAKRSARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N456</accession>
    <name>A0A0F7N456_9ACTN</name>
    <protein>
        <submittedName>
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        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
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        <lineage>
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            <taxon>Actinobacteria</taxon>
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        </lineage>
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    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AKH83425">
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    </dbReference>
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    <dbReference type="PATRIC" id="fig|444103.5.peg.3325"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HATPase_C"/>
    </dbReference>
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        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
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        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
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    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
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            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
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            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
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            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="3">
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            <begin position="312"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="344"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH83425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="414" mass="41911" checksum="5B5E82EBEA1FB7D9" modified="2015-07-22" version="1">MTGARGEWAGGRGVRRLASSPDGPVAAAALLTLLAAVDTVLHTGAGDRLTAALLLAFGAAAPVALLRTHPAPAAVLTTAANAPLAALLGAPVAAGVAAQALLLHRLARHGTRRARTLAVLLVLPLAGYAVGDPGTAAGGRLDAAGRLLAVAAAVLLAAATATGLAHRTRSTAAAHSATERAIAHALYEHAARGERARIARELHDVVAHHISMISVQAETARLTTPGLPDEGARRLRDIGDTARTALTEMRRLLGVLREDAGAAPAERRPPPGLAQLNELLDGARDAAGAAVRLIVSGAVRPLGTGIELTAYRIVQEALTNARRHAPGAAVDVELHYTGTALRLRIRDNGPGPGPDPGHGPDPGFAGGGHGLPGMRERAAAVGGRLRSGPAAGGGFLLEATLPARTRTSREETAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N476</accession>
    <name>A0A0F7N476_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Mini-circle protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_11850</name>
    </gene>
    <organism evidence="1 2">
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        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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        </lineage>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_11850"/>
    <dbReference type="EnsemblBacteria" id="AKH82811">
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        <property type="gene ID" value="AA958_11850"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_11850"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2491"/>
    <dbReference type="OrthoDB" id="2047691at2"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="DUF664"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH82811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="161" mass="17379" checksum="BAB9BE53AD6245E2" modified="2015-07-22" version="1">MATASRRRDTPPPRTGATEAETLRGFLDYLRTSIAAKVESAPEPQVRTAGVPSGTNLLGLLHHLAYVERATFLGERVTDWPSTFEAPAASTVVEIVADYREAVAGANRVLDDCTDLGAQVPRRGGKAPSVRWALTHMIEETGRHAGHADILREHIDGTTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4B7</accession>
    <name>A0A0F7N4B7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_08270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015578.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_08270"/>
    <dbReference type="EnsemblBacteria" id="AKH82228">
        <property type="protein sequence ID" value="AKH82228"/>
        <property type="gene ID" value="AA958_08270"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_08270"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1744"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
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    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
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    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
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    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAF" evidence="1">
        <location>
            <begin position="165"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="336"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH82228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="685" mass="73939" checksum="E7F539C9EE85950B" modified="2015-07-22" version="1">MSKRGGTAAPAPEAGDWPAPAAVSMELNRMGSFDWDLDGGQMHLDDGALRVFDLRPEEYDGDPQTLGSRVTREEGARLDALISRAIAQDRPAYSAYLRVQLRDGTSRLTHTQGVILRDDGGRAHRVVGMVRDATLELNYSAQQFALDQERRRQTGVVQQTTAALANATTVHDVIGVLGGEEGLARLGAVNMVLGLVDAGRIQIITMGEGTEVQLADFTRVDEPGLPVSEVVRTGRPRLVLSRAEFAAAYPRLYPYVESLRIDCAAFLPLIAEGRVIGALGLSYRDKSAFSPEERNLLVSLSSGIGQSLQRAKLHDREHGLAEDLQQAMLPRSIPEVPGAEVAVRYRAAHEGQGIGGDWYDVIALPGGRVGVVIGDVQGHDTQAAAVMGQLRIVLRAYAGEGHAPATVMARASEFLHELETERFATCTYAEIDLSSGALQLVRAGHIDPLVRHADGGCRVLPVPGGLPLGLSATFGPLDYPVTTMVLDPGDALLMYTDGLVEVPGTDLDQGMAQLAELVRTGPRDIDELSDRLCDVVDERQVEDDMALVMLRRTAGDTAQPGSRLRQYIPPSDPDALSAARHMIRSAVRSWGAGERADEIELVSDELITNALLHTDGPAIVTIRPLSTPERRLRVEVEDRSSALPHRREPGEAGVSGRGLLLVDRLADVWGVEPRGNDKCVWAEFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4F8</accession>
    <name>A0A0F7N4F8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_08540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015621.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_08540"/>
    <dbReference type="EnsemblBacteria" id="AKH82273">
        <property type="protein sequence ID" value="AKH82273"/>
        <property type="gene ID" value="AA958_08540"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_08540"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1802"/>
    <dbReference type="OrthoDB" id="1081028at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036705">
        <property type="entry name" value="Ribosyl_crysJ1_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101478">
        <property type="entry name" value="SSF101478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH82273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="81" mass="9234" checksum="3410F244A6841A1A" modified="2015-07-22" version="1">MRRRWLGSRGGNLAGAYYGLDAIPARWTRPLSDVGEVTTPQIWTRIRDWANSHQIGRMAFWAVNRDRPNGEFTRITAGFTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-08-12" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4V1</accession>
    <name>A0A0F7N4V1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Antitoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_17360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Antitoxin component of a type II toxin-antitoxin (TA) system.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the phD/YefM antitoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016989.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH83685">
        <property type="protein sequence ID" value="AKH83685"/>
        <property type="gene ID" value="AA958_17360"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_17360"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3651"/>
    <dbReference type="OrthoDB" id="2047723at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006442">
        <property type="entry name" value="Antitoxin_Phd/YefM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036165">
        <property type="entry name" value="YefM-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02604">
        <property type="entry name" value="PhdYeFM_antitox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143120">
        <property type="entry name" value="SSF143120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH83685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="84" mass="9472" checksum="F183247D6384958F" modified="2015-07-22" version="1">MRAHLADTIDRARREATPTIITRRGKAEAVILDLDEYQRLRKREESVEDAWLSRLAADSLAEGREPTVTLEDLAAEILGEARQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N567</accession>
    <name>A0A0F7N567_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_06735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015309.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_06735"/>
    <dbReference type="EnsemblBacteria" id="AKH81957">
        <property type="protein sequence ID" value="AKH81957"/>
        <property type="gene ID" value="AA958_06735"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_06735"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1407"/>
    <dbReference type="OrthoDB" id="2032035at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035183">
        <property type="entry name" value="DUF5304"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17230">
        <property type="entry name" value="DUF5304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="148" mass="15837" checksum="A0BE5F107C85D0B5" modified="2015-07-22" version="1">MSDAIERPEPGAASTVPDAWAQACAEDFAAEQARRRAVYGPEPVSAAEELRRFFDSLSDKVSELRAPGATGGTAAVAQTAAQQIAKQFLASVKTVVEPVVERNPQVFDHLATAGTEIAAAYRAAVQRQEADWSRDDEPPSSPKQIDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N588</accession>
    <name>A0A0F7N588_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Glutamine--fructose-6-phosphate aminotransferase [isomerizing]</fullName>
            <ecNumber evidence="2 8">2.6.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">D-fructose-6-phosphate amidotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">GFAT</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Glucosamine-6-phosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Hexosephosphate aminotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">L-glutamine--D-fructose-6-phosphate amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">glmS</name>
        <name evidence="11" type="ORF">AA958_10425</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:13237"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="2.6.1.16"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.6.1.16" evidence="2 8"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015915.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_10425"/>
    <dbReference type="EnsemblBacteria" id="AKH82573">
        <property type="protein sequence ID" value="AKH82573"/>
        <property type="gene ID" value="AA958_10425"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_10425"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2195"/>
    <dbReference type="OrthoDB" id="43416at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004360">
        <property type="term" value="F:glutamine-fructose-6-phosphate transaminase (isomerizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901137">
        <property type="term" value="P:carbohydrate derivative biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05008">
        <property type="entry name" value="SIS_GlmS_GlmD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05009">
        <property type="entry name" value="SIS_GlmS_GlmD_2"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00164">
        <property type="entry name" value="GlmS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035466">
        <property type="entry name" value="GlmS/AgaS_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035490">
        <property type="entry name" value="GlmS/FrlB_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005855">
        <property type="entry name" value="GlmS_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937:SF0">
        <property type="entry name" value="PTHR10937:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01135">
        <property type="entry name" value="glmS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 11" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 8 11" id="KW-0808">Transferase</keyword>
    <feature type="initiator methionine" description="Removed" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="9">
        <location>
            <begin position="2"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="10">
        <location>
            <begin position="285"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="10">
        <location>
            <begin position="457"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; for GATase activity" evidence="8">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="active site" description="For Fru-6P isomerization activity" evidence="8">
        <location>
            <position position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AKH82573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="604" mass="65652" checksum="04C97AE3B55ABC2A" modified="2015-07-22" version="1">MCGIVGYIGKRDAAPLLLEGLQRLEYRGYDSAGVAIAARSGALKTVKAKGRVRDLEARLPKRFAGATGIAHTRWATHGAPSDANAHPHLDEAGKVAVVHNGIIDNAADLRAKLAADGVELTSETDTEVLAHLVGRSVAATLEEAVRETMLLVEGTYGIAVLHADHPDRIVVARNGSPVVLGIGEREMFVASDVAALVSHTRQVVTLEDGEMATIKADDYRTYTTEGSRTSSSPETVEWSPESYDMAGHDTYMHKEICEQAEAVDRVLRGRIEDRFSTVHLGGLNLDAREARAVRRVKILGCGTSYHAGMIGAQLIEELARVPADAEPASEFRYRNPVVDPDTLYVAVSQSGETYDVLAAVQELKRKGARVLGVVNVVGSAIARETDGGIYVHAGPEVCVVSTKCFTNTVVAFALLALHLGRIRDLSVADGRRVLEGLRRLPEQIAEMLRGEDEIRALAKEYAHARSMMFIGRVRGYPVAREAALKLKEVSYIHAEAYPASELKHGPLALIEPEVPTVAIVPDDELLEKNRAALEEIKAREGRILAVAHRRQEKADHTIVVPRSEPELDPLLMGIPLQLFAYHTALELGRDIDKPRNLAKSVTVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5F8</accession>
    <name>A0A0F7N5F8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CopG family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_14770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH83276">
        <property type="protein sequence ID" value="AKH83276"/>
        <property type="gene ID" value="AA958_14770"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_14770"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3112"/>
    <dbReference type="OrthoDB" id="1906285at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH83276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="92" mass="10434" checksum="0E88C61B79049519" modified="2015-07-22" version="1">MATKKVTVTIPEDLLEEIRAEAAERGLSAYVAEALRFQRDRDRLRELSDWLQEEHGPLAEDERAAAFAELEELDAEHERRRAVGTRSDGEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5Z4</accession>
    <name>A0A0F7N5Z4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_11930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH82824">
        <property type="protein sequence ID" value="AKH82824"/>
        <property type="gene ID" value="AA958_11930"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_11930"/>
    <dbReference type="OrthoDB" id="2074213at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="103" mass="11280" checksum="B9A255A79C583C0A" modified="2015-07-22" version="1">MSNSSPGTEEQLRDALEAFAEGVRPTPGAYRVAHGDWQRRERRRRLVLAVLIAVVFTLATLIGLWVLNQAPSRPGVIFDDGVSTGNAQPADRTDPPHWNCGCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5Z6</accession>
    <name>A0A0F7N5Z6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aamy domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_08365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015591.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_08365"/>
    <dbReference type="EnsemblBacteria" id="AKH82242">
        <property type="protein sequence ID" value="AKH82242"/>
        <property type="gene ID" value="AA958_08365"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_08365"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1765"/>
    <dbReference type="OrthoDB" id="148706at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="1">
        <location>
            <begin position="16"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="173" mass="18750" checksum="5A90352D58631007" modified="2015-07-22" version="1">MATPSVPWWRDAVMYQVYLRSFLDSDGDGVGDLRGARTGLPYLATLGVDGLWLSPCSPSPQHDHGHDVADYCASDPLFGGLHDFDGLLADAHSLGFKVILDVVPHHCSAQHPRFREALGAEPGSAARKRFHFAGGRGTGGELPPNNWRAMFGGHSVLERSQQLSDFPALSRNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N612</accession>
    <name>A0A0F7N612_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribosomal RNA small subunit methyltransferase I</fullName>
            <ecNumber evidence="7">2.1.1.198</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">16S rRNA 2'-O-ribose C1402 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">rRNA (cytidine-2'-O-)-methyltransferase RsmI</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rsmI</name>
        <name evidence="9" type="ORF">AA958_12120</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>cytidine(1402) in 16S rRNA + S-adenosyl-L-methionine = 2'-O-methylcytidine(1402) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42924"/>
            <dbReference type="Rhea" id="RHEA-COMP:10285"/>
            <dbReference type="Rhea" id="RHEA-COMP:10286"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74495"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.198"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the methyltransferase superfamily. RsmI family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.198" evidence="7"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016193.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_12120"/>
    <dbReference type="EnsemblBacteria" id="AKH82858">
        <property type="protein sequence ID" value="AKH82858"/>
        <property type="gene ID" value="AA958_12120"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_12120"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2550"/>
    <dbReference type="OrthoDB" id="1059309at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070677">
        <property type="term" value="F:rRNA (cytosine-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000453">
        <property type="term" value="P:enzyme-directed rRNA 2'-O-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11648">
        <property type="entry name" value="RsmI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01877">
        <property type="entry name" value="16SrRNA_methyltr_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008189">
        <property type="entry name" value="rRNA_ssu_MeTfrase_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46111">
        <property type="entry name" value="PTHR46111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005917">
        <property type="entry name" value="MTase_YraL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00096">
        <property type="entry name" value="TIGR00096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="8">
        <location>
            <begin position="5"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH82858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="284" mass="30029" checksum="7348103061D110BE" modified="2015-07-22" version="1">MSGLLVLAGTPIGDPADAPPRLATELAAADIIAAEDTRRLRRLTQALGVQPTARVVSYFEGNESARTPDLVEELAGGARVLLVTDAGMPSVSDPGYRLVDAAVRRGITVTAAPGPSAVLAALAVSALPVDRFCFEGFLPRKPGERLSRLREAAAERRTLVYFEAPHRLGDSLAAMAGVFGEDRRAAVCRELTKTYEEVRRGPLGELADWAAEGVRGEVTVVVEGAPVDRERPGATELARRVTVREEAGEGRKDAIAAVARDAGVPKRDVFDAVVAAKNSANNSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N647</accession>
    <name>A0A0F7N647_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_19875</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017355.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_19875"/>
    <dbReference type="EnsemblBacteria" id="AKH84065">
        <property type="protein sequence ID" value="AKH84065"/>
        <property type="gene ID" value="AA958_19875"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_19875"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4188"/>
    <dbReference type="OrthoDB" id="1688736at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="35"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="286"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="94"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH84065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="320" mass="35149" checksum="01D7DC0C1EE11ABD" modified="2015-07-22" version="1">MTSIAAQQERAPGAVKRAAAPAGRRKLGRKGRERLAAALFLLPDTLGLGLFVVLPMLLSFVLSFFQVSGFGSYEWIGVGNYERMFNDPYFWSSMWVTAKYVVILVPTLFVVSLSLGVLMKQMLPGMAVYRTALFLPHMLSLVVVGLLWKFMLDDQTGVVNKAAGEAGLGARSWLGDPGLALYAVIAVTVWYYMGYYMIIFLAGLNEIPRELYEAAKIDGAGPWTSFRQITWPLLKPTSFFVLIVSTVAAITGTFDLIFVLTDGGPANGTAVAMFYIYQQAFVFGEYGYAAALGSFLVLVMVALSWLIFKATKGGRFDDEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N658</accession>
    <name>A0A0F7N658_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_19990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017375.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_19990"/>
    <dbReference type="EnsemblBacteria" id="AKH84085">
        <property type="protein sequence ID" value="AKH84085"/>
        <property type="gene ID" value="AA958_19990"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_19990"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4211"/>
    <dbReference type="OrthoDB" id="1555988at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040632">
        <property type="entry name" value="Sulfotransfer_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17784">
        <property type="entry name" value="Sulfotransfer_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="215" mass="24017" checksum="8FCDF18071FF52D5" modified="2015-07-22" version="1">MLEVIGAGVGRTGTLSLKTALERLGFGPCHHMLGLFEDPEQIPMWEAASRGEPVDWRRVYATYGSTVDWPGARFWREIAGAFPEAKVVLTVRDPESWYASAASSIYATAVAPPPPDVGESFLRLRDMSLEVIWDGVFDGRFTEKEHALKVFAEHEAAVREEIPADRLLVFRVSEGWEPLCAFLGVPVPDEPFPRSNERGRFVDEVRERSTAAAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6F6</accession>
    <name>A0A0F7N6F6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NlpC/P60 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_17180</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016960.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_17180"/>
    <dbReference type="EnsemblBacteria" id="AKH83656">
        <property type="protein sequence ID" value="AKH83656"/>
        <property type="gene ID" value="AA958_17180"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_17180"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3613"/>
    <dbReference type="OrthoDB" id="682655at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519829" description="NlpC/P60 domain-containing protein" evidence="3">
        <location>
            <begin position="36"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="NlpC/P60" evidence="4">
        <location>
            <begin position="228"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="52"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="154"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH83656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="342" mass="37429" checksum="70B4912605DD4B02" modified="2015-07-22" version="1">MGAHRRPKSPGRARITTLSFAAGAFTLLSTQSGQAEPKPTVEEVRAEVEKLYEEATGPTEEYNAARERQRGLQEEAEKAQDEAARQQQEINDLRDRIGPLAAEQYRNGGIDPSVQLALSADPDEYLREAELVDRVGHRQASALSVLQDKQRELAQQRRETSAKLREAEEFRTAAAEKKNEVQAKLTEARQLLNSLTAEERARLDAAEERDAAEAGTSDAADTYDGPASGRAKAALDFAYAQLGKPYEWGSTGPDSFDCSGLTGSAWSAAGVSLPRTVKQQYDAGRKVSQADMQPGDIIYWYNDTQHNGMYVGDGKAIHAPRTGKNVEIVPVDSMPFYAASRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6N4</accession>
    <name>A0A0F7N6N4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_13390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016389.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH83058">
        <property type="protein sequence ID" value="AKH83058"/>
        <property type="gene ID" value="AA958_13390"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_13390"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2816"/>
    <dbReference type="OrthoDB" id="2047542at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="22"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH83058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="219" mass="23543" checksum="AD60D958C2E2A36D" modified="2015-07-22" version="1">MATVDGDLIPLGRPRAERADAARNRRLLLDTARRMIAEEGAENVTMDGLAERAGVGKGTVYRRFRTRAGIFVALLDEEERGFQQRVLSGPPPLGPGGDPVDRLIAYGQGRITFLIDHHAVARAALGKNRPVPVALPGLTQVHIRLLLERSGVAADHLDALTLQLTGALEGPVLLYVATPAPEEGEATRYLGALAEGWKVLVTRVCRPWAEPTRSGPAGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6W6</accession>
    <name>A0A0F7N6W6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Uncharacterized N-acetyltransferase AA958_13710</fullName>
            <ecNumber evidence="4">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_13710</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">Homohexamer; trimer of dimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the acetyltransferase Eis family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="4"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016444.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_13710"/>
    <dbReference type="EnsemblBacteria" id="AKH83114">
        <property type="protein sequence ID" value="AKH83114"/>
        <property type="gene ID" value="AA958_13710"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_13710"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2886"/>
    <dbReference type="OrthoDB" id="1497065at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01812">
        <property type="entry name" value="Eis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041380">
        <property type="entry name" value="Acetyltransf_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025559">
        <property type="entry name" value="Eis_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022902">
        <property type="entry name" value="NAcTrfase_Eis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036527">
        <property type="entry name" value="SCP2_sterol-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17668">
        <property type="entry name" value="Acetyltransf_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13530">
        <property type="entry name" value="SCP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55718">
        <property type="entry name" value="SSF55718"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="5">
        <location>
            <begin position="5"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Acetyl-CoA binding" evidence="4">
        <location>
            <begin position="85"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Acetyl-CoA binding" evidence="4">
        <location>
            <begin position="93"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; via carboxylate" evidence="4">
        <location>
            <position position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH83114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="418" mass="45585" checksum="112FBCB3C49694AA" modified="2015-07-22" version="1">MNDGTEIRTLTEGDVAGWMRAMQTGFMRPPSVTEADVELFLKTRDLSRTRGAYDGRRWVGTYRSFDQELTVPGGAAVSSCAVSAVTVSPTHRRRGLLSRMLREDMEAAKERGDVVASLIAAEYPIYGRYGFGPAAWTTDYDVTTPRAQLDPRYAGPDDGGTVELLDAAELTAIAPALHDRFRRLVPGAVNRSATRWQAHTGAARYSVDEPWHEPFYAAYRSAAGEPEGIVTYRTKWGDWPGKLSDDELTVTDLFAVTPAAERALWRYLVSFDWITTIHTGHRAPDDLLPLHLGDPRAARVTTHADYLWLRPLDVPRLLEARAYAASGSLVLDVHDPAGLAGGRFLLDAGGPGGTGCVPTDRPADLALSVAELARLSLGDESAVRLAALGVVDEERPGAAARADALLRTSRRPWCPDMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N733</accession>
    <name>A0A0F7N733_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH lysR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_14270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_027773288.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_14270"/>
    <dbReference type="EnsemblBacteria" id="AKH83204">
        <property type="protein sequence ID" value="AKH83204"/>
        <property type="gene ID" value="AA958_14270"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_14270"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3003"/>
    <dbReference type="OrthoDB" id="990666at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="6"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH83204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="314" mass="33828" checksum="740E5B4700CF892C" modified="2015-07-22" version="1">MLNPDVRLEWFVSFLAVIETGSFVAAAESTKRSQPRVSMHVAALEREIGLPLFDRRKRPVELTEAGIVLADHAHEILRALESAEAAMAPWRSGARGVVTLGSYPSASAAFVPALLQGLARTSPEVRVVLVERSTLELDDALTSGAVDVYLRPMSPPPSSASVRSRLLWGESLVAIHPSEHPLSEVPDPLPVDAVAEHPIVSIGRLDAPETPDFETYRTFRDCGHEIEPVQATNQPQTLVSMVRQGIGVGVTNSLAARVADVDGVRVRRLKGAPERRVAVCWDSSRPLTPSARTLLRAIVRARIPAGTHAVPAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7A9</accession>
    <name>A0A0F7N7A9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Methylthioribose-1-phosphate isomerase</fullName>
            <shortName evidence="2">M1Pi</shortName>
            <shortName evidence="2">MTR-1-P isomerase</shortName>
            <ecNumber evidence="2">5.3.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">S-methyl-5-thioribose-1-phosphate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mtnA</name>
        <name evidence="3" type="ORF">AA958_11310</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>S-methyl-5-thio-alpha-D-ribose 1-phosphate = S-methyl-5-thio-D-ribulose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:19989"/>
            <dbReference type="ChEBI" id="CHEBI:58533"/>
            <dbReference type="ChEBI" id="CHEBI:58548"/>
            <dbReference type="EC" id="5.3.1.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 1/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.23" evidence="2"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016059.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_11310"/>
    <dbReference type="EnsemblBacteria" id="AKH82722">
        <property type="protein sequence ID" value="AKH82722"/>
        <property type="gene ID" value="AA958_11310"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_11310"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2383"/>
    <dbReference type="OrthoDB" id="1290468at2"/>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00874"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046523">
        <property type="term" value="F:S-methyl-5-thioribose-1-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019284">
        <property type="term" value="P:L-methionine salvage from S-adenosylmethionine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
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        <property type="entry name" value="IF-M1Pi"/>
    </dbReference>
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        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
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        <property type="entry name" value="Initiation_fac_2B_a/b/d"/>
    </dbReference>
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        <property type="entry name" value="M1Pi_N"/>
    </dbReference>
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        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="eIF-2B_rel"/>
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    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00512">
        <property type="entry name" value="salvage_mtnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="1 2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="55"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="254"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="244"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="2">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH82722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="367" mass="37390" checksum="1CF0AF0D1EDEE031" modified="2015-07-22" version="1">MAEEIAALRWEEPSDGGDGPAVVLLDQTRLPADEVELVCADVPALVRAIQTLAVRGAPLLGIAGAYGVALAAARGDDVDQAAALLAGARPTAVNLAYGVRKAQDALRAALEAGDGGAGAAGAALDEARRLHADDARASARMAEHGLRLLGELVPQGGYRVLTHCNTGALVSGGGGTALAVVLAAHRSGELRRLWVDETRPLLQGARLTAYEAERAGMPYTLLTDNAAGSLFADGQVDAVILGADRIAADGSVANKVGTYPLAVLARYHRVPFLVVAPTTTVDFSTPEGSAIEVEQRAGGEVTEFSVPYAAGPGPGQAAVTYAVAPAGTQAYNPAFDVTPPELVTAVVTERGVAAPVTGDSLAELVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7T5</accession>
    <name>A0A0F7N7T5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Luciferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_15985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016771.1">
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_15985"/>
    <dbReference type="EnsemblBacteria" id="AKH83459">
        <property type="protein sequence ID" value="AKH83459"/>
        <property type="gene ID" value="AA958_15985"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_15985"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3368"/>
    <dbReference type="OrthoDB" id="1434838at2"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="20"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="297" mass="32032" checksum="80F3EABAAC5F6129" modified="2015-07-22" version="1">MRLSTLILPVRRWHSGGRAQWQRAEELGFSAAYTYDHLSWRTFRDGPWFGALPTLTAAACATSRLRLGTLVTSPNFRHPVTLAKELISLDDVSGGRMILGIGAGGSGFDATALGQQPWAGRERTERFGEFLPLLDTLLTQDTTSYAGTYYSAHEVRMIPGCVQRPRLPFAVAATGPRGMRLAARYGQSWVTTGDPQTSATGTAADSLAAIRAQIARLAEAGAAVGRDTAAMEKVLLAGFTPDRPLDSLDAFVDFAGRHAALGFTEIVLHWPVPDSVFAADERVFERIATEAPAQLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N828</accession>
    <name>A0A0F7N828_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_12765</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016287.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_12765"/>
    <dbReference type="EnsemblBacteria" id="AKH82952">
        <property type="protein sequence ID" value="AKH82952"/>
        <property type="gene ID" value="AA958_12765"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_12765"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2682"/>
    <dbReference type="OrthoDB" id="295501at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="187"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="226"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="287"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="348"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="374"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="403"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="432"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH82952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="700" mass="74040" checksum="3BA8C3A8947A781D" modified="2015-07-22" version="1">MTTVQPDREAASGGRSADGAAAGADGGRPAPASAGSGDPADPAGQSTADESGGGTAAGGGDAAPSGAAGAGGGAARTDVKHGGGSEGGTLRTEAAASRAPSAARLRFTPPERFRPHLRWLAQRPVLTTLVAAGILHLLWLLLLANEGGDLAAQDAWAEFAGRHPSTAYNFAWYGGMHPVSYSVVSPYLMAVLGVRTTMVLAGTLSAGVLALILARCRYVPRPLVPSLFGAVALVGNAASGRVTFALGLLFALVAIALVFRDDRDDEDEEGEEAGKGRRPVGGWRGTAIVLTSMLATAASPVAGLFAGVVATGLFLQKRRTEAYLLGAAPPVVVALSSWLFPFQGNMPMPWISAVAPMITAALIWLMAPESWRTVRIVAAIYFLGTLGAWVIPSPVGSNIERLALIFGGTVLLVIAQTGTRQAAPRLMRSVRAAYLAFAAITVWVIVKPVVDLVLTSPTAAWTRELAPLVDQLQQVDAEAGRVEVVPVRSHREASALQPYVSLARGWNRQADLDRHEIFYDGSLTPKTYHAWLKTWAVRYVVLPVEDRPDTGAHEEAKIVAEGQPYLTEIWADANWRLFRVNDPTPLVEAPAEVRRADEGELVIDVKYAGPVLVRVPFSPWLGLVDEDGEGVEAPQVLEGDGSDGADVDGVREWSESGQLYVNLEGCVTKAGEWTRLHAPRPGTYRISAPYQLPRGTHCPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8J6</accession>
    <name>A0A0F7N8J6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">tRNA N6-adenosine threonylcarbamoyltransferase</fullName>
            <ecNumber evidence="6">2.3.1.234</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">N6-L-threonylcarbamoyladenine synthase</fullName>
            <shortName evidence="6">t(6)A synthase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">tRNA threonylcarbamoyladenosine biosynthesis protein TsaD</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">tsaD</name>
        <name evidence="8" type="ORF">AA958_21440</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>adenosine(37) in tRNA + L-threonylcarbamoyladenylate = AMP + H(+) + N(6)-L-threonylcarbamoyladenosine(37) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:37059"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.3.1.234"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="6">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the KAE1 / TsaD family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.234" evidence="6"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017599.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_21440"/>
    <dbReference type="EnsemblBacteria" id="AKH84336">
        <property type="protein sequence ID" value="AKH84336"/>
        <property type="gene ID" value="AA958_21440"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_21440"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4514"/>
    <dbReference type="OrthoDB" id="1257362at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061711">
        <property type="term" value="F:N(6)-L-threonylcarbamoyladenine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01445">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017861">
        <property type="entry name" value="KAE1/TsaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017860">
        <property type="entry name" value="Peptidase_M22_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022450">
        <property type="entry name" value="TsaD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="PTHR11735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF6">
        <property type="entry name" value="PTHR11735:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00789">
        <property type="entry name" value="OSIALOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00329">
        <property type="entry name" value="gcp_kae1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03723">
        <property type="entry name" value="T6A_TsaD_YgjD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01016">
        <property type="entry name" value="GLYCOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TsaD" evidence="7">
        <location>
            <begin position="27"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="137"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH84336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="369" mass="38141" checksum="DFB82D333C2A47BE" modified="2015-07-22" version="1">MADEPLVLGIETSCDETGVGIVRGHTLLADAIASSVDAHARFGGVVPEVASRAHLEAMVPTIGRALRDAGVAARDLDAIAVTAGPGLSGALLVGVSAAKAYAYALGKPLYGVNHLASHIAVDQLEHGALPEPTMALLVSGGHSSLLMSADITADVRPLGATIDDAAGEAFDKVARVLGLGFPGGPFIDRAAREGDPAAIRFPRGLTGPRDPVYDFSFSGLKTSVARWVEARRAAGEDVPVADVAASFQESVADVLTRKAVRACRDNGVGHLMIGGGVAANSRLRAMAERRCEDAGIVLRVPRPKLCTDNGAMVAALGAEMVARGRAASDWELSADSSLPVTETHVPGHEHAPGHGHDHVHELAKDNLYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8R2</accession>
    <name>A0A0F7N8R2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Branched-chain amino acid ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_18665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_18665"/>
    <dbReference type="EnsemblBacteria" id="AKH83888">
        <property type="protein sequence ID" value="AKH83888"/>
        <property type="gene ID" value="AA958_18665"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_18665"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3914"/>
    <dbReference type="OrthoDB" id="2078961at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008407">
        <property type="entry name" value="Brnchd-chn_aa_trnsp_AzlD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05437">
        <property type="entry name" value="AzlD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003203">
        <property type="entry name" value="AzlD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="111" mass="11445" checksum="C060E83F69F0C822" modified="2015-07-22" version="1">MPDTPAAGYLLAAVAVAVAVTWALRALPFAALAPLRSSPLVAYLDAAMPVGVMVILAAYTLRHLAPRDPGAAWPTVLALAATVAVHLWRRNVLLSILGGTAVHVVLASAVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8R6</accession>
    <name>A0A0F7N8R6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ribosomal methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_18700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017190.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_18700"/>
    <dbReference type="EnsemblBacteria" id="AKH83893">
        <property type="protein sequence ID" value="AKH83893"/>
        <property type="gene ID" value="AA958_18700"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_18700"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3921"/>
    <dbReference type="OrthoDB" id="215562at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024019">
        <property type="entry name" value="CHP04096"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04096">
        <property type="entry name" value="dnd_rel_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH83893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="480" mass="53836" checksum="F913D727C1D767E1" modified="2015-07-22" version="1">MTQQLWSSQRHQTAIGRVGLSLPARRAVGDLQLEPQAGVLDYGCGRGGDVRALRHLGLDAEGWDPVHFPDGQREPAEVVLLTYVLNVIENPAERRETLLRAWDLAKSALVVSARLRWERNQIKGTEYGDGILTRRRTFQHLYAAGELRDYVEEATGVRCVSAAPGIVYAFKDDAARLGYLARQVAPDGGWLASEDTAAAITSVVAHLEERGRMPQLEEMPQPIISLLGHLRAAELKRLAEQEADPVKVERSAERGALDTLLFLALELFHGRGPVSSLPLPVQLDIRAFFPSYAEACQRADRLLFKLRDDAYVRRAMNGSIAGKFTATALYVHRRALHRIPAVLRLYEQCASIAAGRPGEWSVVKLRHQGRGVSWLDYPEFDTDPHPRIAASYAVDLKTLKSSFTSYADSRNRPLLHRKHEFLAEDDPDAPKYRRLTDAEVRAGLYESPHLIGTEEGWERELVRCERALRGHRLLRRTAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8Z2</accession>
    <name>A0A0F7N8Z2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycine amidinotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_19360</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the amidinotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017278.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_19360"/>
    <dbReference type="EnsemblBacteria" id="AKH83983">
        <property type="protein sequence ID" value="AKH83983"/>
        <property type="gene ID" value="AA958_19360"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_19360"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4070"/>
    <dbReference type="OrthoDB" id="592329at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015067">
        <property type="term" value="F:amidinotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033195">
        <property type="entry name" value="AmidinoTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10488">
        <property type="entry name" value="PTHR10488"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="active site" evidence="3">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="258"/>
        </location>
    </feature>
    <feature type="active site" description="Amidino-cysteine intermediate" evidence="3">
        <location>
            <position position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR633195-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH83983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="383" mass="42858" checksum="C08CB3D9015150EB" modified="2015-07-22" version="1">MPRLNSHDDFTPLREVVVGSAANYMGHDRDVSFELFHHENLSGFRSDWAYPRLTRTAGGHRESWAIKERYAEELHEDVEALAAVLAGLGTVVHRPLPLPPDAAPIAGLGWQAAPTPALNIRDNTLILGDEIIETPPAIRSRYLETRLLAPVFTAYWEAGARWTTMPRPTLTDNSFDLSYARDTATTLGGPTEAVDDPQPSPYDVGVEMMLDGAQVLRLGRDLVVNVAQANHARGAEWLQRHLGDRYRVHRVWRMADNHIDSMILALRPGVFLARHDGIRDLMPEPLRSWRYIVPPEPDAGAFPVYDDYEDLVLTSPYIDLNVLSVDEDTVLVNEDCTGLAKALDAAGFTTVPVRHRHRRLFGGGFHCFTLDTVREGTREDYLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N941</accession>
    <name>A0A0F7N941_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">3-isopropylmalate dehydratase small subunit</fullName>
            <ecNumber evidence="10">4.2.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Alpha-IPM isomerase</fullName>
            <shortName evidence="10">IPMI</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Isopropylmalate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">leuD</name>
        <name evidence="12" type="ORF">AA958_25735</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 10">Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>(2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate</text>
            <dbReference type="Rhea" id="RHEA:32287"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="EC" id="4.2.1.33"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 10">Heterodimer of LeuC and LeuD.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the LeuD family. LeuD type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.33" evidence="10"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018301.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_25735"/>
    <dbReference type="EnsemblBacteria" id="AKH85055">
        <property type="protein sequence ID" value="AKH85055"/>
        <property type="gene ID" value="AA958_25735"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_25735"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5421"/>
    <dbReference type="OrthoDB" id="1384217at2"/>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00071"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009316">
        <property type="term" value="C:3-isopropylmalate dehydratase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003861">
        <property type="term" value="F:3-isopropylmalate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01577">
        <property type="entry name" value="IPMI_Swivel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01031">
        <property type="entry name" value="LeuD_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004431">
        <property type="entry name" value="3-IsopropMal_deHydase_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033940">
        <property type="entry name" value="IPMI_Swivel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00171">
        <property type="entry name" value="leuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 10" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 10" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase_C" evidence="11">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AKH85055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="203" mass="22404" checksum="D5C3CC5DE4F3CAAD" modified="2015-07-22" version="1">MEAFTTHTGRAVPLRRSNVDTDQIIPAHWLKKVTRDGFEDGLFEAWRKDPEFVLNDAAYRGGSVLLAGPDFGTGSSREHAVWALQNYGFKAVVSSRFADIFRGNSLKNGLLTVVLPQPDVERLWELAEADPRTEVTVDLQALEVRAGGTAGEPAFAASFELDENARWRLLNGLDDISITLRYEADIAAFEAARPAFKPQTVQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N950</accession>
    <name>A0A0F7N950_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Recombination protein RecR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">recR</name>
        <name evidence="9" type="ORF">AA958_14685</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the RecR family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016582.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_14685"/>
    <dbReference type="EnsemblBacteria" id="AKH83267">
        <property type="protein sequence ID" value="AKH83267"/>
        <property type="gene ID" value="AA958_14685"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_14685"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3093"/>
    <dbReference type="OrthoDB" id="1661836at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01025">
        <property type="entry name" value="TOPRIM_recR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00017">
        <property type="entry name" value="RecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000093">
        <property type="entry name" value="DNA_Rcmb_RecR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000445">
        <property type="entry name" value="HhH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023627">
        <property type="entry name" value="Rcmb_RecR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023628">
        <property type="entry name" value="Rcmb_RecR_C4-type_Zn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015967">
        <property type="entry name" value="Rcmb_RecR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034137">
        <property type="entry name" value="TOPRIM_RecR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30446">
        <property type="entry name" value="PTHR30446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00633">
        <property type="entry name" value="HHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02132">
        <property type="entry name" value="RecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13662">
        <property type="entry name" value="Toprim_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111304">
        <property type="entry name" value="SSF111304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00615">
        <property type="entry name" value="recR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01300">
        <property type="entry name" value="RECR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Toprim" evidence="8">
        <location>
            <begin position="79"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="7">
        <location>
            <begin position="56"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH83267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="199" mass="21706" checksum="A990CA74EB05B143" modified="2015-07-22" version="1">MYEGVVQDLIDELGRLPGVGPKSAQRIAFHILQAEPADVRRLAHALTEVKEKVRFCAVCGNVAQEEHCRICADPRRDPAVLCVVEEPKDVVAIERTREFRGRYHVLGGAISPIEGVGPDDLRIRELLARLADGAVTELILATDPNLEGEATATYLARMVKAMGLKVTRLASGLPVGGDLEYADEVTLGRAFEGRRLLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9C3</accession>
    <name>A0A0F7N9C3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Diguanylate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_19710</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017326.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_19710"/>
    <dbReference type="EnsemblBacteria" id="AKH84034">
        <property type="protein sequence ID" value="AKH84034"/>
        <property type="gene ID" value="AA958_19710"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_19710"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4154"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="207"/>
            <end position="281"/>
        </location>
    </feature>
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        <location>
            <begin position="278"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="4">
        <location>
            <begin position="431"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="183"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH84034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="563" mass="60599" checksum="F2898ED23F2BC42A" modified="2015-07-22" version="1">METEAEPYVRLASLRRLHSVLADLNQTRSLADTLQSVADGLVALGYEVSAVNLVRPDGDLVVAAVGGDPTAEAIMAGRVGPREAWERRLRMGIEWGELRYIPHSEGWVLDGDEVPQTHSVVPPPSAPGDWVTGDRLFAPIYDAGRELLGVLSVDKPANGRVPTPWGREALQMYASQAAIAITNARLRANMQRALVRLEREQQALRASEESFRQAFEYAPSGMAVAEMGGDDHGRLIRTNDALCRLLGRQPSSLRRLSFSDLVHPEDVGTLLRTFAEGGKTELRLARRDGTYVWVSLRNSVVADAADGPRYLLTHVEDIEERKRHEAQLAHRASHDSLTGLPNAAELRARLTARLCDRPPELYTGAVSHSAAGLPGPRGRAIVGAGPVPREVDSNGHGFGTDGAEEQWAGPGPYEHHVHAMAPGAGGESGGKGLAVLFCDLDGFKSINDRFGHNTGDAVLIAVAQRLTHAVRDGDTVARLGGDEFVVLADGLTPGGAEDLAVRLRNAIIPPIRVDGRGVRVGASIGTGWAVCGMSTEEILSSADQLMYREKRARSQGRSHRRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9D5</accession>
    <name>A0A0F7N9D5_9ACTN</name>
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        <submittedName>
            <fullName evidence="2">Acetyltransferase</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">AA958_26265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
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    <dbReference type="EnsemblBacteria" id="AKH85150">
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        <property type="gene ID" value="AA958_26265"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_26265"/>
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    <dbReference type="OrthoDB" id="1983082at2"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="177" mass="19527" checksum="45F7DDCD5226934E" modified="2015-07-22" version="1">MDDVVVGPLDLAARVDDALAVQAVAFGLTDDEIAVRRHVVLRHLTNTGARALGATTATGRLAGFVYGMPNNRVYWWSTVVQPYLRAAGEDRWLDDAFVITELHVHPAFQQRGIGRELITRITDSAAEPRSLLSAIDVESPARHLYRQLGYRDLARRVVFPGAPSPYVVMGAELPLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9E6</accession>
    <name>A0A0F7N9E6_9ACTN</name>
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        <submittedName>
            <fullName evidence="3">Cytochrome C biogenesis protein ResC</fullName>
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    </protein>
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        <name evidence="3" type="ORF">AA958_20355</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_20355"/>
    <dbReference type="EnsemblBacteria" id="AKH84148">
        <property type="protein sequence ID" value="AKH84148"/>
        <property type="gene ID" value="AA958_20355"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_20355"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4287"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Cyt_c_assmbl_TM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02683">
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        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="DsbD" evidence="2">
        <location>
            <begin position="20"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH84148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="251" mass="26386" checksum="A6B584CF75190670" modified="2015-07-22" version="1">MEPNQTVLTGALLLALPVAVLGGLVSFFSPCVLPLVPGYLSYVTGVSGTDLENARRGRMAAGAGLFVLGFTAVFVSTGAFFGGVGNNLLEHRETISKVVGALTIVLGLMFMGILGRTLGGFTQREFRIHKRPAVGLAGAPMLGMVFGIGWTPCIGPTLISVLALSTNEASAGRGALLTVAYCLGLGLPFIVAAIAFRRALGAFAWVKRHYVWVMRIGGGMLVVTGILLLTGAWDRIINEMQVWTSNYTVGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9R0</accession>
    <name>A0A0F7N9R0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA-binding protein S4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_24115</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HSP15 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018038.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_24115"/>
    <dbReference type="EnsemblBacteria" id="AKH84786">
        <property type="protein sequence ID" value="AKH84786"/>
        <property type="gene ID" value="AA958_24115"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_24115"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5082"/>
    <dbReference type="OrthoDB" id="2006597at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016821">
        <property type="entry name" value="HSP15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S4" evidence="4">
        <location>
            <begin position="8"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="86"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="98"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH84786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="132" mass="14608" checksum="A43917B852A96EBF" modified="2015-07-22" version="1">MAGEDGSVRVDSWIWSVRLTKTRSAAATACKAGHVRVNGDRVKPAQALRVGDEVRVRLAGRERIVVVKRLLRKRVGAPVAVECYADHSPPPPPREMAAPVARRDRGTGRPTKRDRRELERLRGRAERDGAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9S5</accession>
    <name>A0A0F7N9S5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_15820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016744.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH83432">
        <property type="protein sequence ID" value="AKH83432"/>
        <property type="gene ID" value="AA958_15820"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_15820"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3334"/>
    <dbReference type="OrthoDB" id="1681849at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="155" mass="17105" checksum="AA596B51329CE9BB" modified="2015-07-22" version="1">MAATAEQLDELARGWVALASLHARIETHVERTLQRTHRLSAREYSVLDALSRQDDFHLRMNQLADTVVLSQSATTRLVTRLEDRGLLSRHLCPDDRRGIYTEVTPAGRRLLAEARPGYEASLRAALDEAAKRPELAPLVAAVEALEAPAPAAYAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9T0</accession>
    <name>A0A0F7N9T0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cobalamin biosynthesis protein CobW</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_27255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018550.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_27255"/>
    <dbReference type="EnsemblBacteria" id="AKH85315">
        <property type="protein sequence ID" value="AKH85315"/>
        <property type="gene ID" value="AA958_27255"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_27255"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5743"/>
    <dbReference type="OrthoDB" id="1267701at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011629">
        <property type="entry name" value="Cbl_biosynth_CobW-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07683">
        <property type="entry name" value="CobW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00833">
        <property type="entry name" value="CobW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CobW C-terminal" evidence="1">
        <location>
            <begin position="241"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="385" mass="41076" checksum="9154DC2444DEA160" modified="2015-07-22" version="1">MAEDPSPLPVVVVAGLHREARRRAVETLLRAVPGAVAVHHDLDAIEDGRVPRTLRDADGVRERGRPRMTAPCACCAVRDDLVPTLLSLAVGGTYPLVVVELWDSVEPRALAELIAAAPAEALRLTGVVTVVDVDSLVPYLTCGEDLAEQGLALAPTDRRTVADTFARQLEYPPLLAVTCLGDPDPADVALLEQLHATARRVSLGSPELARAALAGVDVDAAATRHHPACALLPQEADGHGVATLVWRRARPLHPGRLYAALEDLTCAAVRSRGRLWLADRPDALLTWDATGGALCIEHAGPWLAALPEAAWELEPAARRVAAALDWHPEHGDRGQHLTFTGPGLDRTTLRRMLDSCLLTDAEYAAGPDGWRALSTAFDALLGIPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9V9</accession>
    <name>A0A0F7N9V9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5 7">50S ribosomal protein L16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rplP</name>
        <name evidence="9" type="ORF">AA958_21210</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 7">Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 7">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uL16 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_027754754.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_21210"/>
    <dbReference type="EnsemblBacteria" id="AKH84293">
        <property type="protein sequence ID" value="AKH84293"/>
        <property type="gene ID" value="AA958_21210"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_21210"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4467"/>
    <dbReference type="OrthoDB" id="1786618at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01433">
        <property type="entry name" value="Ribosomal_L16_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01342">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016180">
        <property type="entry name" value="Ribosomal_L10e/L16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036920">
        <property type="entry name" value="Ribosomal_L10e/L16_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000114">
        <property type="entry name" value="Ribosomal_L16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020798">
        <property type="entry name" value="Ribosomal_L16_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12220">
        <property type="entry name" value="PTHR12220"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00252">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00060">
        <property type="entry name" value="RIBOSOMALL16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54686">
        <property type="entry name" value="SSF54686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01164">
        <property type="entry name" value="rplP_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00586">
        <property type="entry name" value="RIBOSOMAL_L16_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00701">
        <property type="entry name" value="RIBOSOMAL_L16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L16" evidence="8">
        <location>
            <begin position="4"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH84293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="139" mass="15753" checksum="DC5B40A6FAA6FDFD" modified="2015-07-22" version="1">MLIPRRVKHRKQHHPKRRGLAKGGTELAFGDYGIQAATAAYVTNRQIEAARIAMTRHIKRGGKVWINIYPDRPLTKKPAETRMGSGKGSPEWWVANVKPGRVMFELSYPNEKTAREALTRAAHKLPMKCRIVRREGGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9X5</accession>
    <name>A0A0F7N9X5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7 8">DNA replication and repair protein RecF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">recF</name>
        <name evidence="10" type="ORF">AA958_16225</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7 8">The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the RecF family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016803.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_16225"/>
    <dbReference type="EnsemblBacteria" id="AKH83497">
        <property type="protein sequence ID" value="AKH83497"/>
        <property type="gene ID" value="AA958_16225"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_16225"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3419"/>
    <dbReference type="OrthoDB" id="891841at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00365">
        <property type="entry name" value="RecF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001238">
        <property type="entry name" value="DNA-binding_RecF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018078">
        <property type="entry name" value="DNA-binding_RecF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042174">
        <property type="entry name" value="RecF_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32182:SF0">
        <property type="entry name" value="PTHR32182:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00611">
        <property type="entry name" value="recf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00617">
        <property type="entry name" value="RECF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00618">
        <property type="entry name" value="RECF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7 8" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="SMC_N" evidence="9">
        <location>
            <begin position="3"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="30"/>
            <end position="37"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AKH83497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="377" mass="40985" checksum="0C73E015E23361A2" modified="2015-07-22" version="1">MHVSHLSLADFRSYEQAEVPLDPGVTAFVGPNGQGKTNLVEAVGYLATLGSHRVSADAPLVRMGAARAVVRAAVTQDGRQQLVELELNPGKANRARLNRSSQVRPRDLLGVLRSVLFAPEDLALVKGDPDQRRRFLDELITARAPRLAGVRSDYDRVLKQRNTLLKTAAMARRHGGRQLDLSTLDVWDQHLARAGAELLAQRLELIAVLQPLVDKAYEQVAPGGGPTAFEYRSPAGGRFAEARTREEFAGLLLEAMAEARKQEIERGVTLVGPHRDDLVLKLGELPAKGYASHGESWSYALALRLASYELLRGEGGGEPVLVLDDVFAELDARRRERLAELVAPGEQVLVTAAVAEDVPEVLAGARFTVADGRVERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAN4</accession>
    <name>A0A0F7NAN4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycerophosphodiester phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_26165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_26165"/>
    <dbReference type="EnsemblBacteria" id="AKH85131">
        <property type="protein sequence ID" value="AKH85131"/>
        <property type="gene ID" value="AA958_26165"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_26165"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5508"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="SSF51695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GP-PDE" evidence="1">
        <location>
            <begin position="8"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="231" mass="25223" checksum="149DC3D2AB64A5A1" modified="2015-07-22" version="1">MTGAAPAVLAVAHRGDPYVVRENTLGSLRSAVAAGADAVEFDVRLTWDGVPVLLHDRTLQRLWGQEVNLASLTYAEVQERSEGGIPTLREALKVMADSPGVRSFIDLPDPAAAEHVVAEVLESDAAARTYYCGGTAALLTIRAADPDAEIALTCSSPVPYRAGLLRRLRPQWLNYRFGLLDEATVREDQEAGYKVSCWTVDWPRNWRRLTAMGVDAITSNRIAALRRHLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NB53</accession>
    <name>A0A0F7NB53_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Malate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_23815</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="3">Divalent metal cations. Prefers magnesium or manganese.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the malic enzymes family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017985.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_23815"/>
    <dbReference type="EnsemblBacteria" id="AKH84733">
        <property type="protein sequence ID" value="AKH84733"/>
        <property type="gene ID" value="AA958_23815"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_23815"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5019"/>
    <dbReference type="OrthoDB" id="654531at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004471">
        <property type="term" value="F:malate dehydrogenase (decarboxylating) (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012301">
        <property type="entry name" value="Malic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037062">
        <property type="entry name" value="Malic_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012302">
        <property type="entry name" value="Malic_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001891">
        <property type="entry name" value="Malic_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00390">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03949">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000106">
        <property type="entry name" value="ME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01274">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00919">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="malic" evidence="6">
        <location>
            <begin position="32"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Malic_M" evidence="5">
        <location>
            <begin position="177"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH84733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="404" mass="42035" checksum="59BDBEB80034C1A2" modified="2015-07-22" version="1">MAAEIVNPPSGTDTSDSPDDDYFDPAFALHRGGKMAVQATVPVNDRDDLSLAYTPGVAKVCTAIAEQPELVHDYTWKSQVVAVVTDGSAVLGLGDIGPEASLPVMEGKAILFKQFGGVDAVPVALDCREVDEIVETVVRLAPSFGGVNLEDISAPRCFEIERKLQERLDIPIFHDDQHGTAVVTLAALRNATKLSGRSLGELRAVISGAGAAGAAIAKILVEAGIGDVVVADRKGIVSADREDLTDAKRELAELTNRAGRTGSLESALAGADVFIGVSGGTVPERAVATMAEGAFIFAMANPNPEIHPDVAHKYAAVVATGRSDYPNQINNVLAFPGIFAGALQVRASRITEGMKLAAAEALADVVAAELSPECVIPSPFDERVAPAITRAVAAAARAEGVARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NB78</accession>
    <name>A0A0F7NB78_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PPM-type phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_30030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018988.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_30030"/>
    <dbReference type="EnsemblBacteria" id="AKH85760">
        <property type="protein sequence ID" value="AKH85760"/>
        <property type="gene ID" value="AA958_30030"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_30030"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6341"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="369"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH85760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="603" mass="63797" checksum="B0B33029CFD0D463" modified="2015-07-22" version="1">MQAVSSGRPGAHDGSGAGTELPADRRSPARARAFVRAVITERALATSSLGPRAEELADDAALLVGELVTNALIHAGTPMELRCRVETDPEADDALSGARIDVYDRQPTATVPGATDGTGTGRGLGLQIVSTLADAWGITYRHTEKAVWCRLALPAPGGTEVPVGPLSPVLYQQLQATELAHPLARTEYRGQAGGSRGGTLLAEASELLAGQLDENMVAALATQLMVPRLADWCAVWLLGEDGAMRLTSVWHADEQRIAPLRGDLEPEAPPPKLWTTGTPWPWPQSAGTEEGGSALAFSLVSGGTYRGTLLIGQGGPPEITDSVAHIVEDVSRQVAQALATARQYTRQTSISRALQRRQLPSTLGRLPGMESAIVYEPHASGQTVGGDFYDLFPTGDGRWCFLLGDVQGKDVEAMSVTGLTRHLVRLLAREGHGVESVLRWLNAVMAEDAAEAVSARGEAARPRFLSMVYGELTPDPSAGGAQCRLASAGHPLPLRMTAEGEVGSVVRSQLLLGIDEDAEFSADTFRLAPGETLLCVTDGVTERRDGQRLLDDDNGLAAILRDCAGMGAMAVAERVRQATHDFSPEPVEDDLAVVVLHAEAPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NB98</accession>
    <name>A0A0F7NB98_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PGRP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_30180</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019008.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_30180"/>
    <dbReference type="EnsemblBacteria" id="AKH85780">
        <property type="protein sequence ID" value="AKH85780"/>
        <property type="gene ID" value="AA958_30180"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_30180"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6373"/>
    <dbReference type="OrthoDB" id="1584918at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06583">
        <property type="entry name" value="PGRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036505">
        <property type="entry name" value="Amidase/PGRP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002502">
        <property type="entry name" value="Amidase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015510">
        <property type="entry name" value="PGRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006619">
        <property type="entry name" value="PGRP_domain_met/bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11022">
        <property type="entry name" value="PTHR11022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01510">
        <property type="entry name" value="Amidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00701">
        <property type="entry name" value="PGRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55846">
        <property type="entry name" value="SSF55846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519382" description="PGRP domain-containing protein" evidence="3">
        <location>
            <begin position="42"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="PGRP" evidence="4">
        <location>
            <begin position="66"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="267"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="267"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH85780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="301" mass="31714" checksum="665DD82188D96598" modified="2015-07-22" version="1">MRGVCGSHRPRRPLRWAVTGAGAVIAAVVTVLALSGTPPFAASPDPGERSPKAAADPYAPAKALRPAIVGRKQWGADRRLLDQKPRYADSVHAVVIHHTGHLNDYDCAESPHYVRDMYEAHAVGKGWGDLGYNFLVDRCGTVFEGRLGGVGRAVVGAHTLGLNRGTTGIAVIGTFPEGVPVPKPLRESLAVLIAWKLGLTGIAPTARTQVVSTNSSTRFTEEGSVSVPAVLGHIDAYETNCPGEALVRLLPTLRKEAAQVQSKAKVLVKKDAGRAGTKKAKDRARRAPGSDARPAGTVPDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBI7</accession>
    <name>A0A0F7NBI7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methylene-tetrahydromethanopterin reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_28335</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">To bacterial alkanal monooxygenase alpha and beta chains.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018735.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_28335"/>
    <dbReference type="EnsemblBacteria" id="AKH85501">
        <property type="protein sequence ID" value="AKH85501"/>
        <property type="gene ID" value="AA958_28335"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_28335"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5972"/>
    <dbReference type="OrthoDB" id="1003376at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019949">
        <property type="entry name" value="Luciferase_OxRdatse_group-1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03558">
        <property type="entry name" value="oxido_grp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="2">
        <location>
            <begin position="18"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH85501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="334" mass="35301" checksum="C35C3FF94447B2F2" modified="2015-07-22" version="1">MDIPLSVLDRSLRRKGQDPADALRRTVRFAQEVEGYGFRRFWVSEHHSVPGVAGSAPTVLAAAVAAATSRIRVGTGGVMLPNHRPLVVAEQFGVLGSLFPGRIDMGLGRSLGFTDGIRRALGHGDADAGDFGTALAELLRWFEGAQPAYPGVHAVPAEGLRVPAYVLAIDGGADIAAAHGLPLVIGAGRRPEKLLRAVGRYREAFTPSAQQGAPYVVVAVAAAVADTAEQAADLLLPEAWATVWSRTRGEFPPLTAAEEIRARTLTEREARYLDEARQSQVSGTGDQVAAALGDLVARSGADELLVSLHTPDEDARLESFRRLVELKTAAPAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBL2</accession>
    <name>A0A0F7NBL2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ppx-GppA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_30700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019088.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_30700"/>
    <dbReference type="EnsemblBacteria" id="AKH85860">
        <property type="protein sequence ID" value="AKH85860"/>
        <property type="gene ID" value="AA958_30700"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_30700"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6488"/>
    <dbReference type="OrthoDB" id="1862004at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003695">
        <property type="entry name" value="Ppx_GppA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02541">
        <property type="entry name" value="Ppx-GppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ppx-GppA" evidence="1">
        <location>
            <begin position="12"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="340" mass="36745" checksum="13DD9DA26B62E630" modified="2015-07-22" version="1">MIDAGSHTVRLVVADADGQVPLPLHTAKRQLRLAELAGPDGRLGDRAVGELAAAVGAAREEAARWGVAEPFAFATAVVRDAPNARDIVRAVRERTDVVLQLLPGETEAELTFLAARRWMGWRAGPMAVLDIGGGSFEVACGRSRLPDFAVALPLGAARLTREFFGRHDPPPPAAVKAVRRHVRHRLRDVAARIRWEAPRTTVVTSRTMQQLARLCGAAPGRHGPFVPRTMAQEDLRRAVKQLRGLPAAERARLPGISPARARQSLAGAVVAHTAMKLMSIDVVTVCPWAIREGILLRTVEEGSMSWWTAPPGDEPRVPGQRKAHPGLGLDAIRTQINLAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NC61</accession>
    <name>A0A0F7NC61_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">50S ribosomal protein L4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rplD</name>
        <name evidence="7" type="ORF">AA958_21180</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Forms part of the polypeptide exit tunnel.</text>
    </comment>
    <comment type="function">
        <text evidence="5">One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017564.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_21180"/>
    <dbReference type="EnsemblBacteria" id="AKH84287">
        <property type="protein sequence ID" value="AKH84287"/>
        <property type="gene ID" value="AA958_21180"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_21180"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4461"/>
    <dbReference type="OrthoDB" id="1572673at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01328_B">
        <property type="entry name" value="Ribosomal_L4_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002136">
        <property type="entry name" value="Ribosomal_L4/L1e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023574">
        <property type="entry name" value="Ribosomal_L4_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013005">
        <property type="entry name" value="Ribosomal_uL4/L1e"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10746">
        <property type="entry name" value="PTHR10746"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00573">
        <property type="entry name" value="Ribosomal_L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52166">
        <property type="entry name" value="SSF52166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03953">
        <property type="entry name" value="rplD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="49"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="206"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="49"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH84287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="230" mass="24374" checksum="4B1F5120A4A3653E" modified="2015-07-22" version="1">MSTVDILSPAGEKAGTVELPAEIFDAQVSIPLIHQVVTAQLAAARQGTHKVKTRGEVRGGGKKPYRQKGTGRARQGSIRAPQFAGGGIVHGPVPRDYSQRTPKKMKAAALRGALSDRARLGRIHVVTGVVDGEVSTKAARTLLGKVSERKNVLLVIERDDDLSLLSARNLPDVHILDAGQLNTYDVLVSDDVVFTQAAFERFVAGPVKGGGKSQSPADEVELQKAEGSDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCB4</accession>
    <name>A0A0F7NCB4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SERPIN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_32240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019348.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_32240"/>
    <dbReference type="EnsemblBacteria" id="AKH86120">
        <property type="protein sequence ID" value="AKH86120"/>
        <property type="gene ID" value="AA958_32240"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_32240"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6807"/>
    <dbReference type="OrthoDB" id="1712777at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.497.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023796">
        <property type="entry name" value="Serpin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036186">
        <property type="entry name" value="Serpin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042178">
        <property type="entry name" value="Serpin_sf_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00079">
        <property type="entry name" value="Serpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56574">
        <property type="entry name" value="SSF56574"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SERPIN" evidence="1">
        <location>
            <begin position="286"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="401" mass="41263" checksum="48C1A238FC4EB163" modified="2015-07-22" version="1">MGAEIPRSTVLAVGTMTARWARAAVRDGHGTVFTAAGLWPPAALLAGAADGPARAELEGALGVPAQDAAAAGSELLAALDGMTGVDAALGLWFRGDRIELRPEWAGQLPPGVRGLLTGDGAADRAALDAWAAGRTDGRIPAMPVELSEWTRLVLASALIVRTDWILPFDQEWAAPLRHGPWAGREVNELLHAHGRTDRLRVADTPLGPLTLYEVEGAYSIDVHLALGPEGAPGGEVAGAAVEAVAGAYGLTPGGELREGTRAPGVQVAYHASMDPEPRLVVRTVPFTVAGDHDLLAMPRLFGLESASDDSRGHFPGVTGSEPLAVTSAQQAATATFTAVGFRAAAVTASGVAAAGLPNREAKLVLVRYDRPFAFVAVHRASGLVLAAGWVAEPAEAAADTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-10-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCF5</accession>
    <name>A0A0F7NCF5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_32540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86165">
        <property type="protein sequence ID" value="AKH86165"/>
        <property type="gene ID" value="AA958_32540"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_32540"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6868"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="121" mass="12868" checksum="F764331ED7DA8CBB" modified="2015-07-22" version="1">MRLFPAVLLCIAVLLNLVTPVHLTFIGRFVAAPLIAAAIDTPRITLATAVATIAITTPFLTVVNEPPNLSVTERWVVVSTVVVVSGLALAVNAVVTAAQRRMVSDELLARTTQIRLRPSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCN9</accession>
    <name>A0A0F7NCN9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_26225</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018384.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_26225"/>
    <dbReference type="EnsemblBacteria" id="AKH85143">
        <property type="protein sequence ID" value="AKH85143"/>
        <property type="gene ID" value="AA958_26225"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_26225"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5520"/>
    <dbReference type="OrthoDB" id="384611at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="2">
        <location>
            <begin position="18"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH85143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="482" mass="50834" checksum="10AEB03C0121C4D0" modified="2015-07-22" version="1">MTSTQAFWLAGRQATGEDTLDVTSPWDGRKVGTVSIPTDAQIEEAVAAAHAVKDELAATPAHVRAAALDHVTKQIAARAEEIARLISAENGKPLKWARGEVGRAVSTFRFATEEARRWGSGDGQRLDTDPGGTGRLAFTRRFPYGPVLGIAPFNFPLNLCAHKVAPALAVGAPIILKPAPATPLSGLLLGELLAETDLPAGSWSVLPVPNDRMPALTQDERLPIISFTGSDKVGYDILNSVPGKRVTLELGGNGAAVVLGDYSSDADLDHAAQRIGTFANYQAGQSCISVQRVIADASVYDRLVPRVVAAVEAQVTGDPADEATDVGPMVSEAAAQRLESWVDEAVGAGARVLTGGKRDGASYAPTVLTDVPGGVRISREEAFGPVVTVQRADDEDAAFAAVNNSKYGLQAGVFTHDVQSAFRAQRKLEVGGVIVGDVPSYRADQMPYGGVKRSGVGREGVRYAMEDYTYEKVMVFTGLDAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7ND64</accession>
    <name>A0A0F7ND64_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD-dependent dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_23515</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017937.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_23515"/>
    <dbReference type="EnsemblBacteria" id="AKH84682">
        <property type="protein sequence ID" value="AKH84682"/>
        <property type="gene ID" value="AA958_23515"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_23515"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4958"/>
    <dbReference type="OrthoDB" id="1928091at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="348"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="Epimerase" evidence="3">
        <location>
            <begin position="33"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH84682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="381" mass="40139" checksum="4F215DCB429A44DB" modified="2015-07-22" version="1">MSSPEPNVRAARKAADGGAADEPAPGAWRPVVAVTGAAAGIGALVTERLAASDEVKQVVAIDERRGELPEAHWHVLDVRDPAIADKLRGTDVVVHLALDLDLETDATARTAYNVRGTQTVLTAAAAAGVRRVVLCTSAMVYGALPDNPVPLAEDAELRATEEATGVGDLLEMERLGRRAPRAHPGLNVTVVRPAAVVGGVDTPLTRYFESPRLLVVKGTRPCWQFCHIDDLAAALEFAALEKAEGELAVGCDGWLEQEEVEELTGIRRMELPSAVALGAASRLHRLGLTPSPAGDLAYTMYPWVVSGSRLHDAGWRPQHTNEEVLAELLAEVSGRHTVAGRRLGRKDAAAAGAAGAAGATVALLGTAAVVRRVRKARRGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDB4</accession>
    <name>A0A0F7NDB4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_27850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018648.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_27850"/>
    <dbReference type="EnsemblBacteria" id="AKH85414">
        <property type="protein sequence ID" value="AKH85414"/>
        <property type="gene ID" value="AA958_27850"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_27850"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5870"/>
    <dbReference type="OrthoDB" id="1265024at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021555">
        <property type="entry name" value="DUF3000"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11452">
        <property type="entry name" value="DUF3000"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="230" mass="24180" checksum="457372087BA99269" modified="2015-07-22" version="1">MVAAPGHLVDEPDGPPEGRPGGGALPPPFRRAVEALDSAAVRPEVTLRSTRAPRGIAPFAYALEADVEEGAEGDAEPADGRLVLLHDPDGQDTWRGTFRFVTLLRAELEPEMAADPLLPDVCWSWLTGALDTRGLSYGEPSGTVTRASSHHFGGLAERGTTTKVEIRASWTPQPSRAAGDGAPDAAAHLAAWVEMLCQCAGLPPAAPPAAPEPDAAPIVSLPQRRGSRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDN6</accession>
    <name>A0A0F7NDN6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HisKA_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_28345</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018737.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_28345"/>
    <dbReference type="EnsemblBacteria" id="AKH85503">
        <property type="protein sequence ID" value="AKH85503"/>
        <property type="gene ID" value="AA958_28345"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_28345"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5974"/>
    <dbReference type="OrthoDB" id="1687028at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="51"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="139"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="4">
        <location>
            <begin position="189"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="330"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="156"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH85503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="515" mass="52477" checksum="81C84D6584C04215" modified="2015-07-22" version="1">MPRTASATRPAGSTRRDRLADAGLVLFAGAFSFLSADSVLPEDGAGVSENVLFAEALAAGAACLALPLRRRWPVPLAVALLVADSFGHFFIGPTLVAVFTVAAHRPLRATGWIAALVFARLVGFLATTPDPQDPRTGAGVAYFSLVTAAVVFGLYRRSRRQLVASLRERAEQAEADAALRAEQAQRRAREEIAREMHDVLAHRLSLLSVHAGALEFHPGAPPAEVARAAGVIRDSAHEALQDLRDVIGVLRAPADSGPGAGRPQPTLGDVDRLVAEAGEAGMRIAYAPDVAAAEAVPAATGRTAYRIVQEGLTNARKHAAGTKVTVTLTGSPEKGLTVEVSNPLPHGGGETGSAAHGEHGAGVRRAEAPRNGRPGSGGQRTGRRDPDATAAGRTAGTGRSAGTGPGTDRTAEIRRPAAGTDAADTGRVAVPALAAEPRGGAGRLAAAAVGSGAEGGSGRAGAGTRATGPIPGAGQGLIGLAERTALAGGRLAHTADGDGFHLRAWLPWGRPSRTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDR9</accession>
    <name>A0A0F7NDR9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sugar ABC transporter ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_28845</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018822.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_28845"/>
    <dbReference type="EnsemblBacteria" id="AKH85589">
        <property type="protein sequence ID" value="AKH85589"/>
        <property type="gene ID" value="AA958_28845"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_28845"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6078"/>
    <dbReference type="OrthoDB" id="551294at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="16"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="267"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="48"/>
            <end position="55"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH85589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="511" mass="54163" checksum="CECA39C0A23A0C3F" modified="2015-07-22" version="1">MAPTSDTPPTPATPLLTMTGITKSFPGVRALDGVDLDVVAGEVHCLLGQNGAGKSTLIKVLAGAHQPDDGTIVWQGDETALKSPVAAMRLGIATIYQELDLVMHLSVAENVFLGHERSSGGFIKAREAHSAAQDLLARLGHPEISASTIVGDLSAAGQQVVSMARALSHDVKLIVMDEPSAALDPDEVDNLFRIVADLTEQGVAVIYISHRLEEIRRIGDRVTVLKDGRAVARGLPAQSTSTNEIVTLMTGRNVAHVFPERPEAPGAGKDPVLTLEGLARQGEFAPVDLKLAPGEIVGLAGLVGSGRSEILETVFGARKPTAGRVLVDGRPLRPGSVTAAVKAGIGLAPEERKSQALLMTESVSRNVSISSLTRFSTGGWLDRSGERAAARQAVRDLSLRPDNPDALVRTLSGGNQQKAVLARWLLRDCRVLLLDEPTRGVDVGARAELYALIRRLADEGVAVLLVSSELPEVLGLADRVLVLREGRVVHTAPARDLDEHRVLDLVMEGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDY6</accession>
    <name>A0A0F7NDY6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_11585</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="5">Binds 1 FMN per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the pyridoxamine 5'-phosphate oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019966.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_11585"/>
    <dbReference type="EnsemblBacteria" id="AKH86695">
        <property type="protein sequence ID" value="AKH86695"/>
        <property type="gene ID" value="AA958_11585"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_11585"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2437"/>
    <dbReference type="OrthoDB" id="1542844at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004733">
        <property type="term" value="F:pyridoxamine-phosphate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008615">
        <property type="term" value="P:pyridoxine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000659">
        <property type="entry name" value="Pyridox_Oxase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019576">
        <property type="entry name" value="Pyridoxamine_oxidase_dimer_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10851">
        <property type="entry name" value="PTHR10851"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10590">
        <property type="entry name" value="PNP_phzG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000190">
        <property type="entry name" value="Pyd_amn-ph_oxd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 5" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="6">
        <location>
            <begin position="41"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="PNP_phzG_C" evidence="7">
        <location>
            <begin position="177"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="66"/>
            <end position="71"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
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    <feature type="binding site" evidence="5">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="145"/>
            <end position="146"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
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            <dbReference type="ARBA" id="ARBA00007301"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000190-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH86695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="217" mass="23792" checksum="21F35CD3CEAC5F58" modified="2015-07-22" version="1">MTDLRRLLRGIEVFEGDLPSFDPRETPDEPVALFTSWLLAAVRAGVREPHAMTLSTADAAGDPSARVLILKDVGQDGWQFASDAGSPKGRELAARPYAALTFYWSPLARQVRIRGPVTTADPEVSAADFRARGAAARAEALLARQSRPLADPAERDAAVAGSLARIEADPELVSPGWTLYAVRPRTVEFWQGDKSRRHTRLVYESAPPGWTKHLLWP</sequence>
</entry>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="PATRIC" id="fig|444103.5.peg.376"/>
    <dbReference type="OrthoDB" id="1918103at2"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="24"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
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    </evidence>
    <evidence type="ECO:0000259" key="2">
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            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH86491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="79" mass="8344" checksum="49B8CDC631990E42" modified="2015-07-22" version="1">MANSTTQQPAAGSGKPQLDLTGATWQSSSQGVGDVEIAFVEGYIAMRDGRNPEGPALIFTPGEWRAFVLGARDGEFDLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-10-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NE71</accession>
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                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
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            <begin position="33"/>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="AKH85744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="74" mass="7527" checksum="EC6254E2DB6B7EDF" modified="2015-07-22" version="1">MAQDLGSAAAVILFRRSRTARPANQPAQTIATLATSTAGQPGEKRPMPTPAALSRPAAPGGTHQNAYSVVAAMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NE97</accession>
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        </submittedName>
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    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
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        <lineage>
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                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="10"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="3">
        <location>
            <begin position="92"/>
            <end position="148"/>
        </location>
    </feature>
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        <location>
            <begin position="146"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH85774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="224" mass="24596" checksum="75BECD9C93AD4C58" modified="2015-07-22" version="1">MQHRKVSDLMTRDVVSARDDTPFQEVARLLTENEIAALPVVDNGGRPVGVVSEADLLRKASDRPGTDGRVPLPPLEAWERAKAEGARAEELMSAPAVCAHPDWNVVEAAQLMEVQHIKRLPVVDDVDRLLGIISRRDLLQIFLRKDDAVREEIEHDVLQDTLGLAPAQVSVDVEGGRVTLQGQVESRSLIPIIVRLCTSVDGVVGVTDRLSFRVDDVGRTPLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NEC4</accession>
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        <submittedName>
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    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
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    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_29665"/>
    <dbReference type="EnsemblBacteria" id="AKH85708">
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        <property type="gene ID" value="AA958_29665"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_29665"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6263"/>
    <dbReference type="OrthoDB" id="1074175at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="208"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="269"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="98"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH85708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="303" mass="32813" checksum="9EDEE40A7D28E81F" modified="2015-07-22" version="1">MSAAADTSRQDPVSSTAPTPAGGTGGGRRPRWTRGRVAMLLAALVLAAAWVLPLAYALATSLKPMGEEVETPLTWIGSSVTFDAYDKVWAAGDIPRWMLNTLYISVMTTLLTVLLCAMAAYGFARTEFRGRKALYALVLAGIMVPPQVLMAPLFAEMAALGLVDTYWGVILPQVAVPAMVFILVKFFEGVPRELEEAAFCDGAGRWRVFFTIVLPLSRPILAAVSIFVFIHTWNNFLWPFLVTTDPNGMTLPVGLVNIQSSYGVRYSQVMASLVMAGLPLLVVFALFQRQIVRGVAHTGLAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NEU4</accession>
    <name>A0A0F7NEU4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_16130</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020120.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_16130"/>
    <dbReference type="EnsemblBacteria" id="AKH86816">
        <property type="protein sequence ID" value="AKH86816"/>
        <property type="gene ID" value="AA958_16130"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_16130"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3399"/>
    <dbReference type="OrthoDB" id="989179at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046112">
        <property type="entry name" value="DUF6049"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19516">
        <property type="entry name" value="DUF6049"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519471" evidence="3">
        <location>
            <begin position="45"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="688"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="719"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="719"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="759"/>
            <end position="798"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH86816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="798" mass="84742" checksum="FF68C44F38918CA7" modified="2015-07-22" version="1">MTGSPGGSPARPPAHRRLLTALLLVALLLPAALVQIPTAGTAHAQPSGSRSVNVSVDYLNPSVPSGGDDLTVSGKVTNKTDAKITDPHVSLRLSGPLTSRSEVTQATERTGWLSDYDGTEIDGPGTEELKTLAPGMSRDFSITIPVNRLPLDAPGVYQLAVSLSGTSAAAGYEQVLGIEHTFLPWQPDDLSTKTRLTFVWPVIATPQLTARTEPDEQQTQTPVLASDRLLEQMEPGGRLQQMVALGEELPVTWVIDPDLLATASAMTEAYNVVDEDGETVPGKGQDTARQWLADLRNAVKGREVVALPFGDPDLAAIAHRGRKVSGTLDQLGDATTLARTTVESELHLEPETDLAWPAEGAIDKRIVGVAGAAGAQWILARSDSMTESGLSYTPTAARPIGGGRKALVADAQLSRAFEGDMSRAETYSLAIQEYLAQTLVTTLQQPNLQRSIVVAPQRTPTLGQVQAMAEALGGLDTSTWMTPLNLSSAAVEPADPGANRAVPSTGAYPKKLRKQEIPRAAFERILDTRQHLDNFSVILDNSLRVTVPFGNALLREMSTQWRGRKTEAEAFRREVQGYLEDLTSQVQLIDKSDLTLSGNSGTIPVTVQNNLLQNVRGLELRLTSDVPSRLRIEEERQSIEVAGGHSTSVKFEASARASGPVTITAQLYTADGRPFGAKKTFQVEVTSITSTVLLVIGAGILLLVLAGVRMYSQRKRAARTAETGEEADGNRDEDANGHGGGGTGGAGSPEDSADPGSDGDTGEADKEAHGTHHTGGDRADDTDTESGARSGASERVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NF30</accession>
    <name>A0A0F7NF30_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_18565</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020198.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_18565"/>
    <dbReference type="EnsemblBacteria" id="AKH86871">
        <property type="protein sequence ID" value="AKH86871"/>
        <property type="gene ID" value="AA958_18565"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_18565"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3896"/>
    <dbReference type="OrthoDB" id="1045165at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH86871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="232" mass="25425" checksum="629B1520D26FB54E" modified="2015-07-22" version="1">MHSSVLDTIGEEITGNALPEGHVLTLEQIRERFGVSRTVARETMRILESMGLVRSRRRVGITVQPRASWNVYDPRVIWWRLSGPGRNAQLRSLTELRIAVEPLAAGAAARSASAAERERATEIAATLRTLGEAGDLDRFLEADIAFHTLLLQASGNEMFGALADVVAVVLQGRTQLGLMPHHPEPAALELHEAVADAVAGGRPRDAETGMRELLAEVRHAMLPLWEPRTRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NF42</accession>
    <name>A0A0F7NF42_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_18935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020216.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_18935"/>
    <dbReference type="EnsemblBacteria" id="AKH86886">
        <property type="protein sequence ID" value="AKH86886"/>
        <property type="gene ID" value="AA958_18935"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_18935"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3975"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="265" mass="28188" checksum="A2BA88BFEFA0AB3D" modified="2015-07-22" version="1">MSVSDYTETEGLPKADRKPYKPWSYDTSSAKLYIPRFTAGQDRWFAAALSGEKGKDPSRVAVFAEQPKDKRWELVSVVDLNGTTLPDVALDKDGYAIAVAATGNKHLAADADVLRTAVIDNFATGGTNTGDKVFHPTKASKQQIKVHDETTGKFGKSGTTSFAAGANRFKDAYALETADGGALVLFAHTHRQTDAVAHSGLQINPDKDDNAWLHGIPRTSVTYTFVCIDAATVPAKAAPSRLIGYTCARTDASGPPAGSAPTDRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NF48</accession>
    <name>A0A0F7NF48_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_28875</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_28875"/>
    <dbReference type="EnsemblBacteria" id="AKH87095">
        <property type="protein sequence ID" value="AKH87095"/>
        <property type="gene ID" value="AA958_28875"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_28875"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6084"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010496">
        <property type="entry name" value="3-keto-disaccharide_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029010">
        <property type="entry name" value="ThuA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06439">
        <property type="entry name" value="DUF1080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06283">
        <property type="entry name" value="ThuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ThuA" evidence="1">
        <location>
            <begin position="19"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1080" evidence="2">
        <location>
            <begin position="244"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH87095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="422" mass="46204" checksum="8B25F86147790F4C" modified="2015-07-22" version="1">MSTSAVAEKPAKKAEGEHVLVFSKTAGFRHDSIPDGIETIKQLGADNGFTVDTTENAGVFTPGTLQQYDAVVFLSTTGDVLDAKQQRAFEDYVRAGGGYVGVHAAADTEYDWPFYGGLVGAYFHSHPHNQTATVKVEDHDHPATAHLGEDWVRFDEWYNYRTNPRGNVRVLASLDESSYTGGNMSGDHPIAWCQTYESGRSFYTGGGHTKESYAEPEFRAHLLGGIQYAAGAVESDCSSAESDYTPIFDGTSTEGWKQAGPGSFRLEDGILTSEGGMGMLWYEARQFGSYSLKLDWRMEGDDNSGVFIGFPPSDDPWSAVNNGYEIQIDATDSPDRTTGAVYGFQSADIAARDEALNPPGEWNTFELRVEGERLQIWLNDVKINDFTNTDPARSLADGHIGIQNHGADDQVSFRNILVKDLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NF73</accession>
    <name>A0A0F7NF73_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_29725</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_29725"/>
    <dbReference type="EnsemblBacteria" id="AKH87125">
        <property type="protein sequence ID" value="AKH87125"/>
        <property type="gene ID" value="AA958_29725"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_29725"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6275"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="216"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="290"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH87125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="319" mass="33566" checksum="43274AF292869B01" modified="2015-07-22" version="1">MAFLADGTPAGPAAEDPGKFLVTVLDAVTFAGLLFVAASGFTLIFGLMRTVNMAHGSLFLLAAYLAIRVQEAMVGQSRNIEPAQVGMLDWLVPMLAGAGVAAVAGLAIQQLFLQWNEGQELRQALMTLALTVVLADQMLREFGGLAQTMVWPGAVTHFFSVQGERYPVTRLFILGVAVLVGMLLWLWLTRTGMGTVIRAGVDDREMVRGLGINIKLVFAITFFVGSFLAGVGGVLGASFAGAAPGTDGNWLLNSLVVVIVGGLGSLRGAAAGSLLYGTVVAFSPAYLPSAYSYYAIIMTFVLLALVLAIRPYGLFGRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFD2</accession>
    <name>A0A0F7NFD2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_31885</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020619.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_31885"/>
    <dbReference type="EnsemblBacteria" id="AKH87185">
        <property type="protein sequence ID" value="AKH87185"/>
        <property type="gene ID" value="AA958_31885"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_31885"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6734"/>
    <dbReference type="OrthoDB" id="1020672at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="2"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="124"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="124"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH87185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="217" mass="23951" checksum="AC567ACD6C1AAEA2" modified="2015-07-22" version="1">MRVLVVEDHAELADSVARVLRREGMAVDVVYDGSDALERTMTVDYDVVVLDRDLPGVHGDEVCKELVSQPHHARVLMLTASGTIIDRVEGLNLGADDYLPKPFAYAELVARLRALARRAQPAVPPVLEHGDLRLDPAQRFATRGGERLTLTPKELAVLECLLSAQGRVVSAEELLERVWDEAADPFTTTVKTTINRLRSKLGLPPVIETVPRSGYRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFE5</accession>
    <name>A0A0F7NFE5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_27865</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_27865"/>
    <dbReference type="EnsemblBacteria" id="AKH85417">
        <property type="protein sequence ID" value="AKH85417"/>
        <property type="gene ID" value="AA958_27865"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_27865"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5873"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013595">
        <property type="entry name" value="Pept_S33_TAP-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08386">
        <property type="entry name" value="Abhydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519448" evidence="3">
        <location>
            <begin position="27"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="Abhydrolase_4" evidence="4">
        <location>
            <begin position="426"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="519"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="170"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH85417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="551" mass="58580" checksum="01A5AA55C29B517D" modified="2015-07-22" version="1">MRAAVLYGILGSLALTGLAAAPAADAARSGAPAPAPAHAPAHAPVSRAAEGPGARGVAVAAARAAKAGVDYGPCPAAEGLPNPIECGTVAVPLDYADPGGRQLKLTVSHIGATGPRAERQGKLVFNPGGPGGSGTYFPLLSRSPEWRRLAEAYDFVGYAPRGVQRSGALSCQNPGEFMKAPSNTSERPSEREKRARVEKARAYADGCAEIAGLRHYTSLNNARDLDVLRAALGERKLTYLGASYGTYFGSLYAALYPDHVRRMVFDSPVDPDPRQVWYGNNLRQSAAFEERWADWQRWVAKHDDVYHLGRTRWEVAAAYERARETIEKEPAGGRVGTAQLQAGFLRAAYADGYWAQAATALADFLGGKQRTLVEFAADDPSDNAAEENGNAVYTAVECNDAPWPTDWETWDRDNSRLARVAPFETWANAWMNLPCAFWTGPRQQPLDVRTDAGELPPVLLLAAERDAATPYDGARELARRLGGSADLVTEKDAGSHGLAGGGNGCVNKHVDSYLLTGRTPGDVSCAPHPEPKAERGGKRSAAPGTGGPALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFF0</accession>
    <name>A0A0F7NFF0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_31955</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_31955"/>
    <dbReference type="EnsemblBacteria" id="AKH86068">
        <property type="protein sequence ID" value="AKH86068"/>
        <property type="gene ID" value="AA958_31955"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_31955"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6748"/>
    <dbReference type="OrthoDB" id="1181903at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="9"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH86068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="242" mass="25836" checksum="6B21B0C0E988AC12" modified="2015-07-22" version="1">MTVTSHPVVELTGVTKTYGDVAALRSADVVIRRGELLAVVGPSGSGKSTMLNIMGTLDRPSAGTVRIDGHDIDRLGDRELSALRAGTIGFVFQQFHLAPGVPALDNVADGLLYSGRTRAERRRLAERAMRRVGLGHRLYHEPHQLSGGEKQRVAIARAVLGDPPLLLADEPTGALDSRSGAVVMELLHQLHEAGTTVVVITHDRDIAASLPREVRLKDGSIEHDSAPVAALPAARLSQEAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFR4</accession>
    <name>A0A0F7NFR4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Ribokinase</fullName>
            <shortName evidence="6">RK</shortName>
            <ecNumber evidence="2 6">2.7.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rbsK</name>
        <name evidence="8" type="ORF">AA958_33275</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>ATP + D-ribose = ADP + D-ribose 5-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13697"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:47013"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="6">Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Carbohydrate metabolism; D-ribose degradation; D-ribose 5-phosphate from beta-D-ribopyranose: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.15" evidence="2 6"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019514.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_33275"/>
    <dbReference type="EnsemblBacteria" id="AKH86289">
        <property type="protein sequence ID" value="AKH86289"/>
        <property type="gene ID" value="AA958_33275"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_33275"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.7028"/>
    <dbReference type="OrthoDB" id="1030724at2"/>
    <dbReference type="UniPathway" id="UPA00916">
        <property type="reaction ID" value="UER00889"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004747">
        <property type="term" value="F:ribokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019303">
        <property type="term" value="P:D-ribose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01174">
        <property type="entry name" value="ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01987">
        <property type="entry name" value="Ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011877">
        <property type="entry name" value="D_ribokin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002139">
        <property type="entry name" value="Ribo/fructo_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00990">
        <property type="entry name" value="RIBOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 6" id="KW-0630">Potassium</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="7">
        <location>
            <begin position="8"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="16"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="44"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="250"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="217"/>
            <end position="222"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="249"/>
            <end position="250"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH86289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="304" mass="29818" checksum="34D69F319051EBA8" modified="2015-07-22" version="1">MTTTNPATLAVFGSVNMDLVAYAATAPLRGETVSGREFRTVPGGKGANQAVAAARAGGAVTMIGAVGADAFGGELRAALDGAGVDTAGLRTAPGASGTAHIVVDDDGGNSIVVVPGANGTVTGLASGDDERIAAAGTLLLQLELPVDGVVAAAEAARGHGVRTVLTPAPARPLPGRLLAATDLLVPNEHEAAALTGRSDPHRAAAALLEQVPEVVVTLGGAGSLYAARGREPVVVPALAVRAVDTTAAGDTFVGALCVAYAEGRPMPAALAWAAAAAALAVQRPGASSSMPERAEIDRLAAEGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFV5</accession>
    <name>A0A0F7NFV5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_33500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019551.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_33500"/>
    <dbReference type="EnsemblBacteria" id="AKH86329">
        <property type="protein sequence ID" value="AKH86329"/>
        <property type="gene ID" value="AA958_33500"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_33500"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.7075"/>
    <dbReference type="OrthoDB" id="1400891at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017517">
        <property type="entry name" value="CHP03083_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03083">
        <property type="entry name" value="TIGR03083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="293" mass="30802" checksum="F0A4A25D03F040CE" modified="2015-07-22" version="1">MEPQVNPAEPDLPRLGPPLDTRPLFAPEQRALMSTLHALRPDDWLREAVPGWTVHDVAAHLLGDFYGRLARERDGHTGGPAPAPGEPLETFIHRINQEWVDAHARVSPASLIGALDAAGAGVAAHFAGDPLRGPSLGVSWAGAEPAPRWLDVARDFTEFWTHRQQIRHAAGLPTDPEAGPLAAVLDTFMRALPHTLRDTAAPPGTRVAMAVPGPAGGAWTATATGPGPAGGTRWSLAAPPGDGEPDALVRLDAETAWRLCVRGVEPEAALARAGVAGDRGLAEAACRIVSVIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFV8</accession>
    <name>A0A0F7NFV8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable membrane transporter protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_32095</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020621.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_32095"/>
    <dbReference type="EnsemblBacteria" id="AKH87186">
        <property type="protein sequence ID" value="AKH87186"/>
        <property type="gene ID" value="AA958_32095"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_32095"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6776"/>
    <dbReference type="OrthoDB" id="1274094at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002781">
        <property type="entry name" value="TM_pro_TauE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01925">
        <property type="entry name" value="TauE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH87186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="233" mass="22597" checksum="4FB9A2C358499EE7" modified="2015-07-22" version="1">MAGVLLLGASVQRLAGIGLALVAGPALALVLGPAEGVRLSNCAAGAISAFGLAAVWRQVRPRAMVPLLAAAVCTVPIGAVTASRLPAPVLLTGMGAMVCGAVGLVMAGARAESLRGTGGAVTAGAVSGFMNSSAGIGGPAVSLYAVNAGWTVREFVPNALFYGVVINIFSVAAKGPPDLSAAAWALCAAAVAAGALIGRALGDRVPEAPARWLVLILGLAGGAATLTKGLLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFW1</accession>
    <name>A0A0F7NFW1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_32335</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_32335"/>
    <dbReference type="EnsemblBacteria" id="AKH87191">
        <property type="protein sequence ID" value="AKH87191"/>
        <property type="gene ID" value="AA958_32335"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_32335"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6826"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="64"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH87191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="285" mass="31535" checksum="6D2A049BC86A7DBF" modified="2015-07-22" version="1">MARRQARTAYVFLAPALIFFAIFFYYPIADILNTSMLTGQRTDEFAGFDNYTNAFEDPQARNAFKVTLQFAVATTVGAIVLGMGLAVLINQKLRGSLAFKLALLVPYLTSIAVVGLMWRNILDPELGILNRILSDLGLPTQEWLNTHPVATIVAVTLWMTTGYTMILFLAGLQGIPDVYYEAAKVDGANGWQRFRRITVPLLTPTTLFVSVMAVITGLQAFGQAYIITRGGPGEASDLFVFHIFELAFRARNFGYASALSVLLLLVIVAFTLVQLRIGRDREVQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFW7</accession>
    <name>A0A0F7NFW7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_29120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018861.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_29120"/>
    <dbReference type="EnsemblBacteria" id="AKH85632">
        <property type="protein sequence ID" value="AKH85632"/>
        <property type="gene ID" value="AA958_29120"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_29120"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6137"/>
    <dbReference type="OrthoDB" id="445933at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH85632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="135" mass="14989" checksum="33817BBC05CDE5FC" modified="2015-07-22" version="1">MTEVVHETAAHALLADGTTLQIRPAGPEDNERLLDLYRQMSPENLRLRFPVALVEDLLRTLPEGAFAANRGAGPVDLTGLEQLPLRLSAMVHDLPQITEADLNPLLARPDGITAVDVRVRVLPHRGHDPYLRRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFX2</accession>
    <name>A0A0F7NFX2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alkaline phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_33485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020656.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_33485"/>
    <dbReference type="EnsemblBacteria" id="AKH87211">
        <property type="protein sequence ID" value="AKH87211"/>
        <property type="gene ID" value="AA958_33485"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_33485"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.7072"/>
    <dbReference type="OrthoDB" id="165142at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd07389">
        <property type="entry name" value="MPP_PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018946">
        <property type="entry name" value="PhoD-like_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038607">
        <property type="entry name" value="PhoD-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09423">
        <property type="entry name" value="PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PhoD" evidence="1">
        <location>
            <begin position="136"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH87211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="547" mass="60423" checksum="EF0E9D0494A24D38" modified="2015-07-22" version="1">MAELRLGPLLRYADDTRATVWVETGGPCEAQVRCADGAGGSSRTWQVGGHHYALITVTGLTPGVPTPYRVLLDGHEVWPLPGAPASTIRTPRPGTALRVAFGSCRWAAKPGGGHDPVGPDALDTLSRRLDTDPDAERPDILLLLGDQVYADETSAATREYLAGRRDPGVPPGDQIADYEEYTHLYDESWLDPEVRRLLASVPSCMIFDDHDVIDDWNTSASWLEEIRAEPWWRERILGGLMSYWVYQHLGNLSPDELAADPLYAAVREAGDGTEPLREFAERADADPAAVRWSYRRDLGRTRLLMVDSRAARVLEEKSRTLVDPDEMDWVRRQALADPGAYDHLLIGTSLPWLLPPAVHDAEGWNAALCAGERGARWARLGEKLRRRADLEHWAAFPRSFTELADLIAEVGRGDRAPASVLVLSGDVHHAYVAEPRWPEAAGPAGARPVVAQLTCSPMHNSVPAPIRAGFRFGWSRAGRLLGRVLARHGRLAAPPIEWRKTGGPWFGNQLMTLTLGGRETARLRLEQAREEDGRGTRLVLADERELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NG10</accession>
    <name>A0A0F7NG10_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flavoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_29450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018911.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_29450"/>
    <dbReference type="EnsemblBacteria" id="AKH85682">
        <property type="protein sequence ID" value="AKH85682"/>
        <property type="gene ID" value="AA958_29450"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_29450"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6214"/>
    <dbReference type="OrthoDB" id="324612at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="457"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="477" mass="48636" checksum="84A76C1DA1A2B7F3" modified="2015-07-22" version="1">MPESANGPGRTVVVIGAGPVGLAAAAHLVERDLEPVVLEAGEHVASAVADWSHIRLFSPWRYNVDSAARRLLEQTGWQAPDPEALPSGGELIESYLLPLASTAALSGRIHTGRKVVGVTRDGLDKVRSAGREDRPFLVRTTDTSGAVSDIRADAVIDASGVWGQRNPMGAAGLPAAGESAAASFLSGPLPDVLGKERARFAGKRALVVGMGHSAANTLLALAELAVSEPGTSITWAIRSARADRLYGGGDADGLPARGALGSRLKSLVDFGVITLVPQFSITGFETGDGCCGGGGAVTVHAVAADGPRSVEADTVVAATGFRPDLDMLREVRLSLDTAVEAPSALGPLIDPNNHSCGTVPPHGERELAHPEPGFYIAGVKSYGRAPTFLLATGYEQVRSIAAALAGDRAAADAVELDLPETGVCSTDLPDNSDADCCSAPAAPQGFASGSLHGYSGEPTSAAAPTPSCCAAPDTASH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-10-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NG72</accession>
    <name>A0A0F7NG72_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_34090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86429">
        <property type="protein sequence ID" value="AKH86429"/>
        <property type="gene ID" value="AA958_34090"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_34090"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.7204"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH86429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="85" mass="9351" checksum="169E2FB1A5D1DED1" modified="2015-07-22" version="1">MSRKSEEYILIARARQAATSFSEHRKQSVGQPELAHVVELGDLREQGVQTHRARVALECGQQGGPRLVVLGHQGQQQGVAGWEAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NGT9</accession>
    <name>A0A0F7NGT9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Pirin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_02645</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the pirin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019738.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_02645"/>
    <dbReference type="EnsemblBacteria" id="AKH86513">
        <property type="protein sequence ID" value="AKH86513"/>
        <property type="gene ID" value="AA958_02645"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_02645"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.565"/>
    <dbReference type="OrthoDB" id="833478at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012093">
        <property type="entry name" value="Pirin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008778">
        <property type="entry name" value="Pirin_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003829">
        <property type="entry name" value="Pirin_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13903">
        <property type="entry name" value="PTHR13903"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02678">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05726">
        <property type="entry name" value="Pirin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006232">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pirin" evidence="4">
        <location>
            <begin position="48"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Pirin_C" evidence="5">
        <location>
            <begin position="193"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="298"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH86513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="317" mass="34154" checksum="7DBF87DDB8B8561B" modified="2015-07-22" version="1">MSNLDMKPPVAACGGRADVTAEPVCEVLEARHMPLGESTVVRRLLPNLGRRMVGAWCFVDHYGPDDIAGEPGMQVPPHPHTGLQTVSWLHDGEVLHRDSLGSLQTVRPRELGLMTAGRAIAHSEESPRDHSRMLHGAQLWVALPDAHRATAPAFEHHAELPHVAGGGLSATVILGELAGASSPGTTYTPIVGADVTLTAGTEARLPVEPDYEYAALTMSGEAEVDGLRLAPESMVYLGCGRTELPLRADVDSSLMLLGGEPFAERLVMWWNFVGRHHDEIDRARAEWMSGTGFGEVHGYEGPRLEAPPLPPTPLKPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-10-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NGY1</accession>
    <name>A0A0F7NGY1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_31460</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019215.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH85987">
        <property type="protein sequence ID" value="AKH85987"/>
        <property type="gene ID" value="AA958_31460"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_31460"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6647"/>
    <dbReference type="OrthoDB" id="1439189at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="3"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH85987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="298" mass="33248" checksum="52C58890E4A276D9" modified="2015-07-22" version="1">MDLELRHLRCLVAIVDTGSFTDAAIDLGVSQAAVSRTLLALERILGVRLLHRTSRSVTPTTAGVQVLARARHLLAEADDLVGEATTGHTRLRIGHAWSAAGRHTAEFQRRWAGRHPDVELHLIRTNSATGGLAEGLCDLAIVRTGVDERRYAHAVVGHERRYCAMAADDPFARRRSLLLADIRDRTVLVDRRTGTTTAEMWPEADRPAVEHTRDVDDWLADIATGRRVGLTPESTVAQYRRDGIVYRPVRDAPPVAVRFVWRRHDPHPATHAAVALLQDLYREHEARRGSKARRARGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NGY4</accession>
    <name>A0A0F7NGY4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_31485</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH85992">
        <property type="protein sequence ID" value="AKH85992"/>
        <property type="gene ID" value="AA958_31485"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_31485"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6652"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH85992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="111" mass="11292" checksum="22342FA50B5492F6" modified="2015-07-22" version="1">MLLLDEATAQLDALTEAAVHACIRTRARAGAVVTIAHRLSTVFDAATIVVMESGRIRARGTHDELLAADALYRDLVEALRIASAGSGAAAPAGHAAAPVTVVAPGAPQRTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NGZ4</accession>
    <name>A0A0F7NGZ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tellurium resistance protein terZ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_05775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019809.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_05775"/>
    <dbReference type="EnsemblBacteria" id="AKH86568">
        <property type="protein sequence ID" value="AKH86568"/>
        <property type="gene ID" value="AA958_05775"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_05775"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1209"/>
    <dbReference type="OrthoDB" id="1437267at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd06974">
        <property type="entry name" value="TerD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003325">
        <property type="entry name" value="TerD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02342">
        <property type="entry name" value="TerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TerD" evidence="1">
        <location>
            <begin position="1"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="192" mass="20614" checksum="AD9F3D4D92B0F5CE" modified="2015-07-22" version="1">MSINLSKGQAISLQKSDGGSLSAVRMGLGWQAAERRGLFGKRTREIDLDASAVLFADKEPVDVVFFQHLVSDDGSVRHTGDNLVGGAGQGGDDESILVDLQRVPVHIDQIIFTVNSFTGQTFEEVQNAFCRLVDESNGQELARYTLTGGGTYTAQIMAKVHRTGSGWGMTALGSPANGRTFQDLMPSIQPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NHJ8</accession>
    <name>A0A0F7NHJ8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Robl_LC7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_19425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_19425"/>
    <dbReference type="EnsemblBacteria" id="AKH86904">
        <property type="protein sequence ID" value="AKH86904"/>
        <property type="gene ID" value="AA958_19425"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_19425"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4084"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004942">
        <property type="entry name" value="Roadblock/LAMTOR2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03259">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00960">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Robl_LC7" evidence="1">
        <location>
            <begin position="2"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="132" mass="13936" checksum="C2CD697645F5DAD9" modified="2015-07-22" version="1">MDWLLQDFLNRVPRTVGALLSSRDGIRLALAGLEVDKADTLAAISSGLHSLGRGLGELKTGRKGVRQILIEHDEVLLCVMAGGQGSLLSVAAELDADVRMVGHEMTRLVTRVDEHLAVGARRADASAGEAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NHT5</accession>
    <name>A0A0F7NHT5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF305 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_17150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020154.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_17150"/>
    <dbReference type="EnsemblBacteria" id="AKH86838">
        <property type="protein sequence ID" value="AKH86838"/>
        <property type="gene ID" value="AA958_17150"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_17150"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3606"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005183">
        <property type="entry name" value="DUF305"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03713">
        <property type="entry name" value="DUF305"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519477" description="DUF305 domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="DUF305" evidence="2">
        <location>
            <begin position="35"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH86838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="200" mass="22002" checksum="C72867D43C7B95F8" modified="2015-07-22" version="1">MLAAAVLVCGAFLVVLATGADDDDAPGVPDTGSADAGFARDMIVHHQQAVEMSLIVRDRTGDEDVRRLAYDVVNTQANQRGMLLGWLDEWELPKSSGEPPMAWMGHEMPFEARDGSLMPGMATDTQLRRLRDADGRDAEVLYLRLMTAHHRGGVQMSQMAAGAVETRVVRRLAETTLRGQQSEIKLMRDMLQERGGLMKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NIN5</accession>
    <name>A0A0F7NIN5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">2-hydroxyacid dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_09630</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019911.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_09630"/>
    <dbReference type="EnsemblBacteria" id="AKH86647">
        <property type="protein sequence ID" value="AKH86647"/>
        <property type="gene ID" value="AA958_09630"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_09630"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2029"/>
    <dbReference type="OrthoDB" id="1638924at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00670">
        <property type="entry name" value="D_2_HYDROXYACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2-Hacid_dh" evidence="3">
        <location>
            <begin position="39"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="2-Hacid_dh_C" evidence="4">
        <location>
            <begin position="110"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH86647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="326" mass="34567" checksum="D768A837DEE7E095" modified="2015-07-22" version="1">MSPDVLPRLFDAATRDRLAEVADLEPNLVAADFTGPRAAAALAGAEVLVTCWGCPPLDEAALAAAPELRAVVHAAGSVKHHVTEAVWRRGIAVSSAAWANALPVAEYTVAAVLFANKRVLEVREEYRRRRGPYDWYADHPGAGNYRRTVGIVGASMIGRRVLELLRPYDLSALVYDPYADDGELRALGATPAGLDELCATADVVSVHAPALPSTRHLISRARLASMRDGATLVNTARGSLVDQEALTEELVSGRLHAVVDVTEPEFLPAGSPLYELPNVLLTPHVAGSLAGELPRLGRAAAGELARYAAGLPFAHPVRPESLGHSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NJ27</accession>
    <name>A0A0F7NJ27_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_15835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86807">
        <property type="protein sequence ID" value="AKH86807"/>
        <property type="gene ID" value="AA958_15835"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_15835"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3336"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="139" mass="15227" checksum="9773036C470B6AAA" modified="2015-07-22" version="1">MAFQLVLTEFNERVAAAGYPDLRPVHGMIFQILGTEGATSSELAARLGVTKQAAGQLVDDLERRGYVLRKAHPAGGRRKLVVLTDAARRHLHIAGDVLHDLEAELARRTGTDTPLLRTELLRLVHGLAGDDLPPLRPVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NJB0</accession>
    <name>A0A0F7NJB0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_18720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86877">
        <property type="protein sequence ID" value="AKH86877"/>
        <property type="gene ID" value="AA958_18720"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_18720"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3925"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH86877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="286" mass="31500" checksum="96A54A591CD91A66" modified="2015-07-22" version="1">MAGAHGRVTLVAPFIKREVLAAALSAFPATVEDIKCITRWVPEEVAAGVSDPEIIELAEADKRLRIALCPTLHAKLYLTNERCLIGSANLTGKATGRATNPNIEILVEAPSAHPEIVRVLAEIKARAVEATPHMAALVRIQAELLKEQRPTASDQPREEAQRGWYPVTRRPDALYPYYCGRAQFGRSVEAAIVRDLALLGVPAGLSETEFSDLIESQLREIPALQALVGGNRLSNVELQHALQEQTGMTEEQAQRTTETIAAWLRHFGRFYTDVGTWEIRHGQELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MX82</accession>
    <name>A0A0F7MX82_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_00095</name>
        <name evidence="3" type="ORF">AA958_34165</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH80835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH80835">
        <property type="protein sequence ID" value="AKH80835"/>
        <property type="gene ID" value="AA958_00095"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86436">
        <property type="protein sequence ID" value="AKH86436"/>
        <property type="gene ID" value="AA958_34165"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_00095"/>
    <dbReference type="KEGG" id="strc:AA958_34165"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.20"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_Tnp_1" evidence="1">
        <location>
            <begin position="34"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH80835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH86436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="209" mass="23509" checksum="78775632A7D8636B" modified="2015-07-22" version="1">MAVVFHRNDHHRRQLHDRLRGAVRDAEGRQEEPSAAVIDSQSVKADATVALTSRGFDAGKKINGRKRHMLTDTLGLLLAVLVTPASTTDRDAARILLPTAKGRFGRLARVWADGGYTGHLVDWSAAQFGVVLDIVRRSDDIRGFEVLPRRWVVERSFAWCLRSRRLVRDYERRTDTSEAVVLWSMTMLMSRRLAARDQRRPVPTAGAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MYF3</accession>
    <name>A0A0F7MYF3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_02660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014618.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_02660"/>
    <dbReference type="EnsemblBacteria" id="AKH81255">
        <property type="protein sequence ID" value="AKH81255"/>
        <property type="gene ID" value="AA958_02660"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_02660"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.568"/>
    <dbReference type="OrthoDB" id="1757088at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="149"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="234" mass="25345" checksum="B9151F43A4B68FE3" modified="2015-07-22" version="1">MGLEIEGRASDSPYVSYVWRSRSEGVDRMTAVASACWDLVFWESRAGFQAAVAGPESRTSTAPVPEEAAFFGITFALGTSLTHLPAPLLVDGGVDIPGATRRSFWLKGSHWPVPGPDDAEAFADRLVRAGVLARDPLVSDLMRGGTPDVSARTAQRRFQAATGFTHGAARQIERARHAAVLLREGTAADDVVHRLGYYDEPHLAHALSRFIGRTAGQLRNDPRPARPLALLYKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MYV1</accession>
    <name>A0A0F7MYV1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Enterotoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_00685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH80926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_00685"/>
    <dbReference type="EnsemblBacteria" id="AKH80926">
        <property type="protein sequence ID" value="AKH80926"/>
        <property type="gene ID" value="AA958_00685"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_00685"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.157"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="91"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH80926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="450" mass="48144" checksum="4265EF2212099057" modified="2015-07-22" version="1">MLAARALRDHVDHVTVVERDTYPEEPEPRKGVPQGRHAHILWSGGAEAIEALLPGTLDRLRAAGAHRIGVKEDMVLYSAYGWQHRFPGSHYALTCSRPLLDQTVREAALDHPDTEVLTRTEAHGLLGDRTCVTGVRVRTPDGGTRELPADIVVDATGRGSRLRHWLTDLGLPPAAEESVDTGLTYATRVFRAPAGAPADFPVVSVYADHRTGRPGRNGLLLPIEDGRWIITLSGTRGGEPTADDARFAEFARGLRDPVVADLIEAAEPLTPVRTTRSTLNRRMHLDRLADRPEGLVALGDCVVSLNPIHGHGMSVAAQSARALETSLSRAGGLKPGLARTAQQAIAAAADAPWLLSASQDLCYPDNKATVSDPRLTTQAAQRQGFADLVTSASLVNERVCDALTAVTTLTAPLGSLETPEFLASMRQQGRAPLTAAPLKDAEAAVLRSAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MYV5</accession>
    <name>A0A0F7MYV5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF1918 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_03670</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014793.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH81435">
        <property type="protein sequence ID" value="AKH81435"/>
        <property type="gene ID" value="AA958_03670"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_03670"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.772"/>
    <dbReference type="OrthoDB" id="2069996at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015035">
        <property type="entry name" value="DUF1918"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08940">
        <property type="entry name" value="DUF1918"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1918" evidence="2">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH81435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="67" mass="7238" checksum="7D5D24F8170A725F" modified="2015-07-22" version="1">MQAEVGDKLCVHGRVVGQEDRTAEILEVMGPAGAPPYRVRFDDGHEALVSPGPDSVVRHRDRESGQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MZC4</accession>
    <name>A0A0F7MZC4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MerR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_01550</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
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        <lineage>
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            <taxon>Actinobacteria</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
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        <property type="gene ID" value="AA958_01550"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_01550"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.341"/>
    <dbReference type="OrthoDB" id="1677723at2"/>
    <dbReference type="Proteomes" id="UP000034283">
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    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00376">
        <property type="entry name" value="MerR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="43"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH81066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="240" mass="26080" checksum="D79BEB9EE25AE56C" modified="2015-07-22" version="1">MGDTPRGGTAAPEADRPDRRRARDRHLSIGGVLAVLREEFPEVTISKIRFLESEGLVEPQRSPGGYRKFGAADIERLARILRMQRDHYLPLKVIREQLDADPVAGAGTGASAVAEAPHDPRIDRETLLRTAAVGEDELASWEEFGLVAPDADGLYDADAAAVARLVAELGSYGVQARHLRGLKAAADREAGLVEQVIGPLRRHRSPQTRAHAESTAERLIELSARLHTTLVRSSLRVAGN</sequence>
</entry>
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    </gene>
    <organism evidence="2 3">
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        <lineage>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
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        <location>
            <begin position="26"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="441" mass="46446" checksum="EDC90F28F05ED37A" modified="2015-07-22" version="1">MTTTTPLRAAAAVCLAGALTLTAAACGDDGSTGGGSEGKGAGSITFWDNNGGVRTPVWKEIIADFEKAHPDIDVEYVPIPINDVQSKYDTAIAGGGLPDVGGVTTSYLANMVAQDALEPVGGRIEDGALKGVLAESMTESVRAAGGRGEEMYSVPTSANNGTLWYRTDLFEDAGLAPPTTWDAFYAAAEKLTDKENNAFGYTIRGGEGSIAQALDAMYGQSGITGFWDGEETTVNAPENVAALEKYVGLYGEVTPEADVNNDFVKMVAQFDNGDIGMLSHNLGSYQDHLKALGEGGFAGLPQPTGPGGKRVQVSNPVDGLGLFKSSDNKGAAWKFIEFAAAHEANSAWNEAAAQIPANTEAAGDPWVRESARDNAAFASLTDGSTEIVQLPYYLPDWNDISKTGNEPAFQKVLLGEMSAKEFLDGMADQLNEARAEWQEQQ</sequence>
</entry>
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    <accession>A0A0F7MZL5</accession>
    <name>A0A0F7MZL5_9ACTN</name>
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            <fullName evidence="3">Glycosyl hydrolase</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="3 4">
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        <lineage>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_05515"/>
    <dbReference type="EnsemblBacteria" id="AKH81745">
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        <property type="gene ID" value="AA958_05515"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_05515"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1156"/>
    <dbReference type="OrthoDB" id="1297076at2"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0016787">
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="DUF1080"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519609" evidence="1">
        <location>
            <begin position="30"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1080" evidence="2">
        <location>
            <begin position="134"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH81745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="348" mass="36829" checksum="A53EAA86A7FB9A98" modified="2015-07-22" version="1">MRRTSLPLAGTALAAATLAAGLLAPTATAAGESPAGAAAGDTTCAAPDARSTVRFLDDDSGVPNRAAGGGCTINDLIDDERAWESRGAFVEHTRKVSGSLLRADVIGPAEYVRLLVTAAQSGIGGKHGPAPYDVIFDGSKESFDDWGYVGGRGFELNDDGSLVTGPTPPTGGLGLLWYEKEKFGDFSLRLQFRDERADSGRSNSGVFVRFPGVDPAANPECRTNDPAWVSVNCGHEIQINDSAETSGNDPRKTGSVYGFADLDLAAAKPTGKGVWNDLEIRVVGQQYTVIRNGEVINEFENKPGLPFPGRPDDPGTSGRQFAEGYVGLQNHDTQSVVEFRNIRVRDLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MZP0</accession>
    <name>A0A0F7MZP0_9ACTN</name>
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        </submittedName>
    </protein>
    <gene>
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    </gene>
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="353"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="374" mass="39678" checksum="B312EB0693D3FB1B" modified="2015-07-22" version="1">MSGIVRTQVVVIGSGQAGLSAAYFLRRAGLDFVVLDHSPGPGGAWQFRWPTLTYGKAHRVHDLPGMALTAAEADGTRPAAEVVAEYFGAYERAFELPVRRPVNVAEVREGAGAETGRLQVVTDAGTWSAQALVNATGTWDRPFWPRYPGQETFRGRQLHTAQYRGPQDFAGQRVVVVGGGASGTQHLLELAGTAAETAWVTRRPPVWREGPFTEDWGRAVVARVDERVRAGLPPKSVVGETGLALTDEVRAARAAGVLVRRPMFERITPDGVAWADGTVFGADAILWATGFRAAVDHLAPLRLREPGGGIRMDGTRAARDPRIHLVGYGPSASTIGANRAGRAAVRELTRLLAGTPGRGPGPVPAEPGAVSAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MZZ0</accession>
    <name>A0A0F7MZZ0_9ACTN</name>
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        <submittedName>
            <fullName evidence="2">Methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_02755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_02755"/>
    <dbReference type="EnsemblBacteria" id="AKH81271">
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        <property type="gene ID" value="AA958_02755"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_02755"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.590"/>
    <dbReference type="OrthoDB" id="1739932at2"/>
    <dbReference type="Proteomes" id="UP000034283">
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    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="51"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="272" mass="29436" checksum="A4626C7C2B5A0A32" modified="2015-07-22" version="1">MGEDLSAAAAKGWAVRWELQREQREAGREERFTVVGDLVELITAGRERPVVLDLGCGTGSLASRLKRRMPALDVVAADADPVLLGLGRRMHGTQVRFVDTVIGGIGWQDELELDRPLDAAVSATMLHRLPERVLLEVYGRLHTLLRPGGLLVNAGRLPPEDAAVAELAGEVGSRLAERRRMPGGEDWSSWWDAAAEAPELARLFAERRRRGAAPAGDNGLSLARHVDLLQKAGFAAVGTVWQCGDRCVLVAVRGDEPPTPAEDDVERAPSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N020</accession>
    <name>A0A0F7N020_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_02930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014664.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH81301">
        <property type="protein sequence ID" value="AKH81301"/>
        <property type="gene ID" value="AA958_02930"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_02930"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.626"/>
    <dbReference type="OrthoDB" id="1819400at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009351">
        <property type="entry name" value="YcaQ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06224">
        <property type="entry name" value="HTH_42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH81301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="385" mass="41741" checksum="B025AE4F06ACDBC3" modified="2015-07-22" version="1">MVITTAQRRARLAHRHLLVGPARATSPEEVAEALAGLHATDSPTVALSARARLREPSLAALDRALYEEGSLQRMHAMRRTLWVVPTELVPVFRFAVGETVAARERALLVKQLGTAGPQYDEAWLTAAEERALAALAELGEASAAEVTAAVPELALRYTLSPGKPYESRPRAGSGVMRVLGMEGRIRRTRPLGGWTSGQFRFAVAPPVAPMDPARARAELVRRWLAAFGPGTLADVRWWTGLPLRQVRAALAELGAEEAALDAGVGYVLPGDLGEDPDPGPWAALLPGLDPATMGWRDRDWYTDPAHRTRLFDSAGNAGPTVWWRGEIIGAWAQRRDGAVVHRLLADRGAEARRAVAAEAERLEGWLAEQRLVVSFPAPMTKELTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N067</accession>
    <name>A0A0F7N067_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Probable cytosol aminopeptidase</fullName>
            <ecNumber evidence="8">3.4.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Leucine aminopeptidase</fullName>
            <shortName evidence="8">LAP</shortName>
            <ecNumber evidence="8">3.4.11.10</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Leucyl aminopeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">pepA</name>
        <name evidence="11" type="ORF">AA958_06945</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>Release of an N-terminal amino acid, Xaa-|-Yaa-, in which Xaa is preferably Leu, but may be other amino acids including Pro although not Arg or Lys, and Yaa may be Pro. Amino acid amides and methyl esters are also readily hydrolyzed, but rates on arylamides are exceedingly low.</text>
            <dbReference type="EC" id="3.4.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 8">
            <text>Release of an N-terminal amino acid, preferentially leucine, but not glutamic or aspartic acids.</text>
            <dbReference type="EC" id="3.4.11.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="8">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the peptidase M17 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.1" evidence="8"/>
    <dbReference type="EC" id="3.4.11.10" evidence="8"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015346.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_06945"/>
    <dbReference type="EnsemblBacteria" id="AKH81995">
        <property type="protein sequence ID" value="AKH81995"/>
        <property type="gene ID" value="AA958_06945"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_06945"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1452"/>
    <dbReference type="OrthoDB" id="356206at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00433">
        <property type="entry name" value="Peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00181">
        <property type="entry name" value="Cytosol_peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011356">
        <property type="entry name" value="Leucine_aapep/pepB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000819">
        <property type="entry name" value="Peptidase_M17_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023042">
        <property type="entry name" value="Peptidase_M17_leu_NH2_pept"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008283">
        <property type="entry name" value="Peptidase_M17_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11963">
        <property type="entry name" value="PTHR11963"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00883">
        <property type="entry name" value="Peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02789">
        <property type="entry name" value="Peptidase_M17_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00481">
        <property type="entry name" value="LAMNOPPTDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="SSF52949"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00631">
        <property type="entry name" value="CYTOSOL_AP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 11" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CYTOSOL_AP" evidence="10">
        <location>
            <begin position="375"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="149"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="307"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="381"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="300"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="377"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AKH81995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="533" mass="53722" checksum="473A9D49576C7446" modified="2015-07-22" version="1">MTALTLSSSSATGLRADAVVVGVAKGPKGPVPAPGAEAVDEAYGGKLGAVLEALGASGGEGEVTKLPAPDGLKAPVVVAVGLGAVPEKGAGYDTETLRRAAGSAARALAGAKKAAFALPLDVADDTAAVAEGALLGAYAFNTYRDGGTAADDKGGKGDKDEKGAKGTKGGKAAKGKANGGAKAALGEIALLGAKRDKAHRAAVERAAVLADEVNRARDLVNIPSNDLDPSGFAAAAQQAGKEHGFKVTVTDEKALAKGGYGGILGVGQGSQTPPRLVRLEHRHPQAEQTIALVGKGITYDSGGISLKPAGHNETMKCDMSGAAAVLAAVSAAARLELPVNVTGWLALAENMPSGSATRPGDVLRMYSGKTVEVLNTDAEGRLVLADALTKASEEKPDYMIDVATLTGAMVLALGNRTFGIMANDDAFRTRIHVLAEAAGEQSWPMPMPPELKKGMESPIADIANMGERMGGGLVAGLFLEEFVGEGITWAHLDIAGPAFNTSGPFGYTPKGGTGSAVRTLVAIAEEAAHGDLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0L3</accession>
    <name>A0A0F7N0L3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Branched-chain amino acid ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_00430</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH80884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014250.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_00430"/>
    <dbReference type="EnsemblBacteria" id="AKH80884">
        <property type="protein sequence ID" value="AKH80884"/>
        <property type="gene ID" value="AA958_00430"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_00430"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.102"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH80884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="297" mass="30469" checksum="98585E6E82373357" modified="2015-07-22" version="1">MDTFLTHLAGGLALGAIYALLALGLVVVFKATGVLNFAHPGMVMAAGLVTWQVTDLHAPFVVAVLAGVCAAAAIGVVLELLTSRAVAAQAVVTASVITLGAGIMLQAEINRRLGSRVLDLDDPWGSGVLDIGGLSVAESRAVAITVTLVVVAALFTWLRVSSWGIAARAATEDRETARLMAIPLRRITLAAWALAGLLAGIAVLFLTAFPSPGLDSSTATVALRALPAAIIGGLDSLEGAVLGGFLVGTCEVLAQGYQSRIDFLGQGFSSVVPYVLMMALLLARPAGLFGTREVTRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0R4</accession>
    <name>A0A0F7N0R4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_00795</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH80944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014310.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH80944">
        <property type="protein sequence ID" value="AKH80944"/>
        <property type="gene ID" value="AA958_00795"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_00795"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.179"/>
    <dbReference type="OrthoDB" id="1662606at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH80944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="291" mass="30121" checksum="D18D93132E29A04A" modified="2015-07-22" version="1">MAAGTATLERPTSLPVPADRRVPARPVERRAVWWAACLICGGLAGLLLAVVGTLRGARPSRRRVLIVVWGTVVQAVLACAFAVLGSGGQIRPCAAPGEGGGVWQTARTVLNAPVSGAALLYAAGEGGEIYHCAANGTTAVILDDGFARAGTMYGTVFLTDQRAETQSPRMRKLSEHEARHSDQWALGSLLAGPAAFPALYAADEVFFPGAYNHFEQAAGLEDGGYDPPPDSPPAAGRLAVLSVGVLVGYTLAASPGRRRPAPVVRPGPVPAALHDPGADRGRETAKPAGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0V2</accession>
    <name>A0A0F7N0V2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Streptogrisin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AA958_04810</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014981.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH81626">
        <property type="protein sequence ID" value="AKH81626"/>
        <property type="gene ID" value="AA958_04810"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_04810"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1013"/>
    <dbReference type="OrthoDB" id="1110723at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004236">
        <property type="entry name" value="Pept_S1_alpha_lytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001316">
        <property type="entry name" value="Pept_S1A_streptogrisin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02983">
        <property type="entry name" value="Pro_Al_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001134">
        <property type="entry name" value="Streptogrisin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00861">
        <property type="entry name" value="ALYTICPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519050" evidence="7">
        <location>
            <begin position="39"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="Pro_Al_protease" evidence="9">
        <location>
            <begin position="45"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="8">
        <location>
            <begin position="116"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="261"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="255"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001134-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001134-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AKH81626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="305" mass="31042" checksum="6E5196978B27921B" modified="2015-07-22" version="1">MRIKRTPPLSGTKKRLRLVAALTAALAGAALAVPAAGAAQPPEGFSAATLARADDAVLAADVGGTAWGVDKKTGTLVVSIDETVTNAEVARIKRTAGADAGALRIERMKGKLQSYINGGQAIYASSWRCSLGFNVRSGSTYYFVTAGHCTDGAGTWYSNSGRTTTIGPTVGSSFPTNDYGLVRYSNTSQTHPGTVNLYNGSSQDITRAANATVGQSVQRSGSTTGLHGGSVTALNQTVNYGGGDIVYGMIRTNVCAEPGDSGGPLFSGTTALGLTSGGSGNCSTGGTTFFQPVVEALNAYGVSVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N108</accession>
    <name>A0A0F7N108_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_05135</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase U62 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015036.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_05135"/>
    <dbReference type="EnsemblBacteria" id="AKH81681">
        <property type="protein sequence ID" value="AKH81681"/>
        <property type="gene ID" value="AA958_05135"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_05135"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1079"/>
    <dbReference type="OrthoDB" id="958356at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045569">
        <property type="entry name" value="Metalloprtase-TldD/E_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035068">
        <property type="entry name" value="TldD/PmbA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036059">
        <property type="entry name" value="TldD/PmbA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19289">
        <property type="entry name" value="PmbA_TldD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111283">
        <property type="entry name" value="SSF111283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PmbA_TldD_C" evidence="3">
        <location>
            <begin position="229"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH81681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="469" mass="49886" checksum="80F549D383724D5D" modified="2015-07-22" version="1">MTRTTRTTEPHETVERALELSRADGCVVIADEESSANLRWAGNALTTNGETRGRTLTVIATVGGREGTASGVVSRAAVTADDLEPLVRAAEAAARESGPAQDARPLVEGVPHSADFAEPPAETSSDVFAAFAPALGESFARARAGGRQLYGFANHTLTSTYLGTSTGLRLRHDQPTGTLELNAKSPDRTKSAWAGRSTRDFTDVDPAELDAELAQRLAWAERTVELPAGRYETLLPPSAVADLLVYMFWSASGRDAHEGRTVFSKPGGGTRVGEKLAGLPLTLRSDPAEPGLESAPFVVAHASTDDWSVFDNGLPVGPTDWVREGTLQHLLTSRFTGDLTGLPVTPEADNLVLDGGGTKSLDEMVAGLGHDGPGLLLTCLWYIREVDPATLLLTGLTRDGVYLVEKGEVTGAVNNFRFNESPVDLLGRAAEAGATERTLPREWGDWFTRAAMPPVRVPDFNMSSVSQGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N113</accession>
    <name>A0A0F7N113_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_05185</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015046.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_05185"/>
    <dbReference type="EnsemblBacteria" id="AKH81691">
        <property type="protein sequence ID" value="AKH81691"/>
        <property type="gene ID" value="AA958_05185"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_05185"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1089"/>
    <dbReference type="OrthoDB" id="1687028at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="88"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="163"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="3">
        <location>
            <begin position="316"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="382"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH81691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="411" mass="42861" checksum="0ACF2998BA8D351A" modified="2015-07-22" version="1">MTAAAQTDANSEHTVFRYLATAIEDGRETARDARAYAKDAGFAAAVALGCVGTMLLAPDGRTGFDALAWVLGLIGSVALVARHRFPRAVLVIAAAAMVAYQLRGYPDGSPVLPMLVAVYRSIRGGHRGFFAVTALLSLVVSLGSLPLLPLGDEALRAALEKRFLTFGWVVACAMGAAMRIQHEAMLAQAEERAAENAQRSADEERLRIARELHDTLTHSISVIKVQAGVAVHLSKKRGEEPPPALLAIQEASGDAARELRSTLHVLRNADGGAEGVGLERLPELVERARGSGVPATVAVAGERPVLPAEVDRAAYRIVQESLTNAARHAGPAAAVGVHVSYAPDKVVVQVDDDGAADPGAPPQPGIGLTGMRERVTALGGELHAAPRPEGGFRVRAELPLPRAGGPAGAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N136</accession>
    <name>A0A0F7N136_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cobalt transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_05330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015070.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_05330"/>
    <dbReference type="EnsemblBacteria" id="AKH81716">
        <property type="protein sequence ID" value="AKH81716"/>
        <property type="gene ID" value="AA958_05330"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_05330"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1118"/>
    <dbReference type="OrthoDB" id="2092143at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="71" mass="7364" checksum="26056ECB89BB5853" modified="2015-07-22" version="1">MAQSAVSPTTDSLLTPVPLRTIAPRALFGGILMLVLVFAAGAGQGAVSLVPGEGVQEWLHDARHLLGFPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N1Q1</accession>
    <name>A0A0F7N1Q1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phytoene dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_06610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015288.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_06610"/>
    <dbReference type="EnsemblBacteria" id="AKH81936">
        <property type="protein sequence ID" value="AKH81936"/>
        <property type="gene ID" value="AA958_06610"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_06610"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1379"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH81936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="515" mass="52535" checksum="E7B00709DAFB7844" modified="2015-07-22" version="1">MAEIAVVGAGMGAMAASARLALAGHRVTVHERSGTHGGGVRRLERDGFGFDTGPGVLYLPAVYRDLFLKTGRRKLEKCVDLVPVDPAERHVFPDGTAATLPNASRAGVVRALDAAAGPGAGEAWTALLDRGRRVWEAARRPLVEEPLPADPGALAADFYPVPPPPAGRGLLRRLRGPRPAAPPATVADVGAGELGAYPALGTMLAQHALAYGFDPRHAPAGAAMLPYVQETFGGWYVRGGMRALADALYERCLERKIEFAFGAEVVAVRVGGDGRAAGVELAGGGRADADVVIAGVPRARLAELAPGGYGDGGNPAAARAVPARMTVCLALRGARDGDAVHRTVVHSPDPARELAWIFDGEKPGTDPEPTVTVLRPDDPAQRPDAEHEAVTVTAVVPAGAWAAGGAEKAAEAFADRMVAAAGRAVPGLAERVLWREVRTPADTAAETGAPGGAVPGPALAGAGGAYLPLPNTTAVPGLYAVGGWAHPGGGLAHAGMSGALVAGLIMEGADFRGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N1Q4</accession>
    <name>A0A0F7N1Q4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_06635</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015293.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_06635"/>
    <dbReference type="EnsemblBacteria" id="AKH81941">
        <property type="protein sequence ID" value="AKH81941"/>
        <property type="gene ID" value="AA958_06635"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_06635"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1384"/>
    <dbReference type="OrthoDB" id="1149616at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028202">
        <property type="entry name" value="Reductase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14759">
        <property type="entry name" value="Reductase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="2">
        <location>
            <begin position="29"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="Reductase_C" evidence="3">
        <location>
            <begin position="344"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH81941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="429" mass="44495" checksum="6305CF80D5744FBD" modified="2015-07-22" version="1">MTDAEPDRAPADRAASRPSRAAGPAAGTVVVGAGMAGVQTAVALREQGYAGAVTLVGAEPHDPYDRPPLSKAVLLGKAEGSAFEVDFAEYGIGLRLGLHADRLDTEGRMLETDAGPVPYENLVLATGAAPIPLPGAPAGATPGVYLLRTLDDAARLRAVLVRRSRVLVVGAGWIGAELTTAAREQGCEVTVVEAAGHPLAAALPAAVAAPMAAWYEESGARLLTGRRVERVESAGEDGPVAVVLDDGTELTADAVVVGIGAHPTTAWLAGSGVALGGDGAVRADERLRTNVPGVWAVGDCASFPSARYGERLLIHHWDNALQGPTTVAADIAGAPGAVYDPVPYFWSEQFGRFVQYVGHHTDRDELLWRGDPDGSSWSVCWLRAGRLIALLAVGRPRDLTQGRKLIHAGAALDRERAADAAVPLKSAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N236</accession>
    <name>A0A0F7N236_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bifunctional uroporphyrinogen-III synthetase/response regulator domain protein</fullName>
            <ecNumber evidence="3">4.2.1.75</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_10980</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.2.1.75" evidence="3"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016003.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_10980"/>
    <dbReference type="EnsemblBacteria" id="AKH82665">
        <property type="protein sequence ID" value="AKH82665"/>
        <property type="gene ID" value="AA958_10980"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_10980"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2312"/>
    <dbReference type="OrthoDB" id="1185397at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004852">
        <property type="term" value="F:uroporphyrinogen-III synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006780">
        <property type="term" value="P:uroporphyrinogen III biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06578">
        <property type="entry name" value="HemD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10090">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036108">
        <property type="entry name" value="4pyrrol_syn_uPrphyn_synt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003754">
        <property type="entry name" value="4pyrrol_synth_uPrphyn_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039793">
        <property type="entry name" value="UROS/Hem4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40082">
        <property type="entry name" value="PTHR40082"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02602">
        <property type="entry name" value="HEM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69618">
        <property type="entry name" value="SSF69618"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="276"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="1">
        <location>
            <begin position="276"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH82665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="382" mass="40804" checksum="35A72153C3F7FD2B" modified="2015-07-22" version="1">MTVPAEVKPLEGFSVGVTAARRADELSTLLARRGAVVHRAPALRIVPLHDDDELLHTTKALISDPPDVVLATTAIGFRGWVEAAGGWGLGEALLDKLAGVELLARGPKVRGAIRAAGLTESWSPASESMAEVLERLLAEGAEGRRVALQQHGEPLPGFVESLRAAGAEVIVVPVYRWMPPEDPAPLDRLLEAVAARGVDAVTFTSAPAAASFLDRAAARHCRDEVLDALRHDVLPACVGPLTALPLERHDVPTAQPERYRLGPLVQLVALELPGRVRTLPVAGHRMEIRGHAVIIDGALRPVPPAGMSLLRALAHRPGWVVSRAELLRALPGAGSDEHAVETAMTRLRTALGVPKLIQTVVKRGYRLSLDPHADTKYAEIRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2F4</accession>
    <name>A0A0F7N2F4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_07980</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the DedA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015531.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_07980"/>
    <dbReference type="EnsemblBacteria" id="AKH82181">
        <property type="protein sequence ID" value="AKH82181"/>
        <property type="gene ID" value="AA958_07980"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_07980"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1683"/>
    <dbReference type="OrthoDB" id="1928533at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032818">
        <property type="entry name" value="DedA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="SNARE_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30353">
        <property type="entry name" value="PTHR30353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="SNARE_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519049" evidence="4">
        <location>
            <begin position="28"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="166"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH82181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="200" mass="20757" checksum="BD56CA7FC051D55A" modified="2015-07-22" version="1">MYAIVATSVLLDVFLPLLPSGALVIMAATAAAGTTTAADAVRNGATLPAADHLAELLALLLCAATASVLGDMLAFRLASRGREKFANSRLLVRAQERLGHHLSGRRGGGIVVLARFAPAGRSVVMLGAGAMHRQVREFLPWSVLAGLLWAAYGVTLGYFGSRWLGAGWLATGVSVLALFVGGLGAAYLVRRPRPQPAASD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2V7</accession>
    <name>A0A0F7N2V7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Stress-induced protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_05510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_05510"/>
    <dbReference type="EnsemblBacteria" id="AKH81744">
        <property type="protein sequence ID" value="AKH81744"/>
        <property type="gene ID" value="AA958_05510"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_05510"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1155"/>
    <dbReference type="OrthoDB" id="1437267at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd06974">
        <property type="entry name" value="TerD_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003325">
        <property type="entry name" value="TerD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02342">
        <property type="entry name" value="TerD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TerD" evidence="2">
        <location>
            <begin position="8"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="TerD" evidence="2">
        <location>
            <begin position="249"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH81744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="435" mass="44280" checksum="BD9C721F6B132CFB" modified="2015-07-22" version="1">MAVDVTAPVRLDVSGLLLTAAGKVRSDDDFVFYNQPSGPGVTHQSGAADTITVDTAGVPADIEKVVVTASLDSGTFSGTEPTATVRDAASGAVIATFTPPQLSSETALVVVEVYRRNGAWKVRAVGQGYSNGLAGIATDFGVSVDEPAPAQAAPAAAPPPPPAPAAPQAPAAPQAPAAPMPPAAPMPPAAPMPPAGQWGAPAAPPPAPPAPGAPPAPGGFGPPPAAPQQPAPPPAAGQPGKVNLDKGRVNLQKNQTVSLVKGGQPLLTTVKMGLGWEPAYGGRRRAKSIDLDASVIAYGPQRNKIDNCFFGKLQILNGAIQHSGDNLTGEGAGDDEVITVHLGGLPPEVTGLVFTVNSFSGQKFTDVAKAYCRLLDGQTGEELVRFDLTSSEPRTGVLMAKFIKQFSGEWEMTALGEFVDSRTVKGMVKPAAAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2Z2</accession>
    <name>A0A0F7N2Z2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">IclR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_02490</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014590.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_02490"/>
    <dbReference type="EnsemblBacteria" id="AKH81227">
        <property type="protein sequence ID" value="AKH81227"/>
        <property type="gene ID" value="AA958_02490"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_02490"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.533"/>
    <dbReference type="OrthoDB" id="370329at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
            <begin position="11"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="4">
        <location>
            <begin position="74"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH81227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="266" mass="28125" checksum="35BA5283A8052D30" modified="2015-07-22" version="1">MAATGGTASGTQSVERALSLLSYFTDEQPERRIAELVELSGLGQSTVSRLVAALESLGYLVRDERSGLHRIGPKVVELAGVALNQSSVHRAARQVAQNLAHELGLGANVAERHGDRMFYLCHFEGPLAPRTFTLTGRSAPLHATAMGKALLSGLAEDEVRDLMGPDYPAYTRRTITGLPGLLDALAETRARGYATEVEELAFGRACLAAPVRDRSGAVVAALSVSGSLSAMDLTARQDTLAARTVEYADQISTGLGYLAHARPAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N303</accession>
    <name>A0A0F7N303_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">DNA repair protein RecO</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">Recombination protein O</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">recO</name>
        <name evidence="10" type="ORF">AA958_09210</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Involved in DNA repair and RecF pathway recombination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the RecO family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015722.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_09210"/>
    <dbReference type="EnsemblBacteria" id="AKH82376">
        <property type="protein sequence ID" value="AKH82376"/>
        <property type="gene ID" value="AA958_09210"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_09210"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1943"/>
    <dbReference type="OrthoDB" id="1758685at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00201">
        <property type="entry name" value="RecO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022572">
        <property type="entry name" value="DNA_rep/recomb_RecO_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003717">
        <property type="entry name" value="RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042242">
        <property type="entry name" value="RecO_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33991">
        <property type="entry name" value="PTHR33991"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02565">
        <property type="entry name" value="RecO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11967">
        <property type="entry name" value="RecO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="SSF57863"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00613">
        <property type="entry name" value="reco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 8" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_rep/recomb_RecO_N" evidence="9">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF11967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AKH82376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="248" mass="26788" checksum="4B8490C12DE2063B" modified="2015-07-22" version="1">MTLFRDDGIVLRTQKLGEADRIISLLTRGHGRVRAVARGVRRTKSKFGARLEPFSHVDVQFFARGSDLVGRGLPMCTQTETIAPYGAPIAADYARYTAGTAMLETAERFTDQEGEPATQQYLLLVGALRTLAGGAHAPQLVLDAYLLRSLAVNGYAPSFGDCARCGLDGPHRFFSVNAGGVLCGDCRVPGSVVPSPEVLALLGALLTGDWHTADRCGAHHVREGSGLVAAYLHWHLERGLRSLRHVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N430</accession>
    <name>A0A0F7N430_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl-CoA hydratase 2</fullName>
            <ecNumber evidence="1">4.2.1.119</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Enoyl-CoA hydratase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_07715</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3R)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:26526"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57319"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="EC" id="4.2.1.119"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="4.2.1.119" evidence="1"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015488.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_07715"/>
    <dbReference type="EnsemblBacteria" id="AKH82138">
        <property type="protein sequence ID" value="AKH82138"/>
        <property type="gene ID" value="AA958_07715"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_07715"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1622"/>
    <dbReference type="OrthoDB" id="942354at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MaoC-like" evidence="6">
        <location>
            <begin position="163"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH82138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="292" mass="30673" checksum="C80B740B58E00628" modified="2015-07-22" version="1">MPIDAARALAAAPRETRIAWTRKDVLLYHLGIGAGRPATDPAELRYVLEDRLRVLPAFVTVAGDGGVAGEGAGLGAPGVDVDLTAVLHGAQRIGLHRPLPPAGEATRTSRIAAVHDKGKAAVLVLRTEAADADGPLWTSDTQLYVRGEGGFGGDRGPSPRLPAPEGPPAHVADRGIREDQALLYRLSGDWNPLHADPEFAALAGFDRPILHGLCSYGMALKAAVDTVLAGDPGRVRSYATRFAGVVYPGETLRIRLWPEAGAPAGTGRIRLTASAVERDESPVLADALIEHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-12-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N447</accession>
    <name>A0A0F7N447_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_11695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016122.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH82786">
        <property type="protein sequence ID" value="AKH82786"/>
        <property type="gene ID" value="AA958_11695"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_11695"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2459"/>
    <dbReference type="OrthoDB" id="1775418at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028978">
        <property type="entry name" value="Chorismate_lyase_/UTRA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011663">
        <property type="entry name" value="UTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07702">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00866">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64288">
        <property type="entry name" value="SSF64288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="2"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="264" mass="28918" checksum="289265237AB4AA19" modified="2015-07-22" version="1">MAPKWRVLADRLAEQIRSGEYLPGAQLPQIRDLVEAGEGSKSTVHAAYKALEAEGLVTSSRGHGTVVRERIPLKRLGIGRYDKAKWRDGDEVAFIADRVASGRPYRRNEQTQTISRVAASATVAQAYGLPEGAEVYARARVVKEGSQPTHTLTSYYRPEHVEGTRLVDPAPGPAGRGGGFRVLYDAGYEIDHMQETLFARIPTADEVQLLQLSPGEWVVELHRTTCTADGTVVEFAIGVHAATRFAWTYDFKVPDSAEAEGEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4R9</accession>
    <name>A0A0F7N4R9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Translation initiation factor IF-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_09310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015739.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
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    </dbReference>
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    <dbReference type="PATRIC" id="fig|444103.5.peg.1964"/>
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    <dbReference type="Proteomes" id="UP000034283">
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    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH82393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="276" mass="30116" checksum="BD8115E304367B7E" modified="2015-07-22" version="1">MNERSPKDALGPHSRVDSTVPHSARVWNYWLGGKDNYEVDRKAGDEMLAFAPALVKSAREDRLFLIRSVRLLAGELGIRQFLDIGTGLPTADNTHEVAQRAASDARIVYVDNDPLVLAHARALLTSTPEGATAYIDADVHDPQEILREAAHTLDFTRPVAVTMLGIVNHMPDVEVARAVIHRLMDAVPAGSYLVISHPTTEVDTEAMHQVADHWNGRGSSPLVIRSAAEVESLFAGLELLEPGVVSCPRWHPDPAETPQVGTRVDVAHYCGVARKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4U2</accession>
    <name>A0A0F7N4U2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_17305</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
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        <property type="gene ID" value="AA958_17305"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_17305"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3639"/>
    <dbReference type="OrthoDB" id="696139at2"/>
    <dbReference type="Proteomes" id="UP000034283">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH83675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="311" mass="35202" checksum="FE470FECA43E628D" modified="2015-07-22" version="1">MTTASHPDPRLLDPKLAKFNPLRRILVHDDFNTGTHGWIELIGNHDQHGDLDTVDAHMSDFRPPQLSSCNFFDVGTHGAMSGTYALKVATRPVTGHTGVAIRRLTMAGRGRVQFETYFAYKAEAASAENGAATAAGGGRWDANNHPSEQQFGALTVATDICDGVRYHNVVRYQNTDPDHEVQHRWMYPTVPEPTPREHFEGKVRLPRTADFTAPDPADWRQFGERQDLCFNEVPTKVNWHYLRWVIDTGTRSNVELQVNDVVHDMSDVPVPPYDEEYGSLQNLLNFYVSVRTHTDVRNFLYLDSVLISVDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5B6</accession>
    <name>A0A0F7N5B6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_10505</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP011492">
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    </dbReference>
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AKH82584">
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        <property type="gene ID" value="AA958_10505"/>
    </dbReference>
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    <dbReference type="PATRIC" id="fig|444103.5.peg.2213"/>
    <dbReference type="OrthoDB" id="1742143at2"/>
    <dbReference type="Proteomes" id="UP000034283">
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    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026841">
        <property type="entry name" value="Aur1/Ipt1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
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        <location>
            <begin position="93"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="PAP2_3" evidence="7">
        <location>
            <begin position="30"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="247"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="263"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH82584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="336" mass="36025" checksum="DAEA25B1E53F75F2" modified="2015-07-22" version="1">MLVVVVYMAYSAGRLLARGDVTMAVDNGLALLDIEKTLHINFEDPLNRLFTAHAVLGVPADFIYASLHYVVTPVVLGWVWLRHRVHYRRYRTWLLLSTVVALVGFILMPTCPPRLLDPAYGFVDTMAQYSSYGWWGGEASAPRGLGGLTNQYAAMPSLHVGWALWCAVVLWRHAPHTPVRLLGVAYPLVTTIVVMGTANHYFLDAVAGAAVMGLGWLLLRPSLRAADGIRRRLYRLASLVGGRGTPAGGGVVAAGGPRPDDPDGSDVPADDRAPEKVRTGGGGAPGDEPEAPHIPSPRATHENPGPGDPPAPSGGRRAPVEQRGAAAQVMCRRLAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5G6</accession>
    <name>A0A0F7N5G6_9ACTN</name>
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        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_07240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_07240"/>
    <dbReference type="EnsemblBacteria" id="AKH82052">
        <property type="protein sequence ID" value="AKH82052"/>
        <property type="gene ID" value="AA958_07240"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_07240"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1517"/>
    <dbReference type="OrthoDB" id="1387978at2"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="137"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH82052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="345" mass="36814" checksum="40BBCA193C33F7B6" modified="2015-07-22" version="1">MTHVDMAETGRSTGNTQAAAPAESRAVYWRRRLREGLGPGTWRRGLVVAALALLDGIVMMGHAAIPNRVGSLGSLVETFLPWFGLAVPVLLVCALWRRSLTAMCALVLPVFVWFHLFGGLLTDKSGGGGDVTVVSHNVAEENTDAAGTARKLVESGADVLALQEVTQDNRSAYEDGLAEAYPYHEVEGTVGVWSKYPLSDTRPVDIHMGWTRALRTTVTTDGGRLAVYTAHLPSVRVKLDAGFTANRRDASANALGEAIKNEPIDRVLLLGDLNGTMNDSALANVTSQLRSAQGAAGSGFGFSWPADFPMARIDQILLRGVQPVSSDVLGETGSDHRPVRASVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5S8</accession>
    <name>A0A0F7N5S8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_11775</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016134.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_11775"/>
    <dbReference type="EnsemblBacteria" id="AKH82798">
        <property type="protein sequence ID" value="AKH82798"/>
        <property type="gene ID" value="AA958_11775"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_11775"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2475"/>
    <dbReference type="OrthoDB" id="385053at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
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    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH82798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="121" mass="12561" checksum="720CA6066809DE38" modified="2015-07-22" version="1">MEERFLTPGWPAAWDRALPGVLGLLADPDPEIRRAAAGIAGSCASPGEVLLPALLDRWRAEPDLVSRLDLVLALGEARTRAPAGDPYDEAGALLHGLLGSPEPQVRLAAVHALAAGDPGFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5X8</accession>
    <name>A0A0F7N5X8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aldose 1-epimerase</fullName>
            <ecNumber evidence="3">5.1.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AA958_08240</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>alpha-D-glucose = beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:10264"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:17925"/>
            <dbReference type="EC" id="5.1.3.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 3">Carbohydrate metabolism; hexose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the aldose epimerase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.3" evidence="3"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015572.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_08240"/>
    <dbReference type="EnsemblBacteria" id="AKH82222">
        <property type="protein sequence ID" value="AKH82222"/>
        <property type="gene ID" value="AA958_08240"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_08240"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1738"/>
    <dbReference type="OrthoDB" id="1512477at2"/>
    <dbReference type="UniPathway" id="UPA00242"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004034">
        <property type="term" value="F:aldose 1-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019318">
        <property type="term" value="P:hexose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015443">
        <property type="entry name" value="Aldose_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005096">
        <property type="entry name" value="GALM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519820" description="Aldose 1-epimerase" evidence="8">
        <location>
            <begin position="39"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="123"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="223"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="364"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="361"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR005096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR005096-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR005096-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR005096-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH82222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="396" mass="42146" checksum="91147626F7BF7528" modified="2015-07-22" version="1">MTQDRAPLAATSATSRRTLLAATAGGLAAAGLAAPAAAETAGRPRKPVREPFGTLADGTRVDRWTLSNGGTRLGVLSYGGIVQSLEVPDRHGRYANVSLGFGDLGDYVALSPYFGALIGRYGNRIAAGRFALDGRTYQLPLNDGDHSLHGGDKGFDKRVWDVEPFTSAAGVGLTLRYVSGDGEMGYPGALTTRVDYTLTAGGDWRIDYAATTSAPTVVNLTSHVYFNLAGEGSGDVYGHELRIAASRYTPVDAGLIPTGELAPVARTPFDFRRAKTIGADLRDDHEQLLYGKGIDHNLVLDKGITRAPERVATVREPSSGRTMSIATTEPGLQFYSGNFLDGSFTGTSGRVYRQGDGFCLETQHFPDSPNQPSFPSTVLRPGDTYRSTTVHSFGTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N634</accession>
    <name>A0A0F7N634_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha,alpha-trehalose-phosphate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_19770</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 20 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017337.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_19770"/>
    <dbReference type="EnsemblBacteria" id="AKH84045">
        <property type="protein sequence ID" value="AKH84045"/>
        <property type="gene ID" value="AA958_19770"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_19770"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4166"/>
    <dbReference type="OrthoDB" id="556566at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019835">
        <property type="term" value="P:cytolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050829">
        <property type="term" value="P:defense response to Gram-negative bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03788">
        <property type="entry name" value="GT20_TPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000293">
        <property type="entry name" value="Channel_colicin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001830">
        <property type="entry name" value="Glyco_trans_20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788">
        <property type="entry name" value="PTHR10788"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00982">
        <property type="entry name" value="Glyco_transf_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00276">
        <property type="entry name" value="CHANNEL_COLICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHANNEL_COLICIN" evidence="2">
        <location>
            <begin position="351"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH84045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="475" mass="51733" checksum="D8876578A1B49D52" modified="2015-07-22" version="1">MVVSPGALLLVASNRGPLSYAVGDDGALVAKRGGGGLVSGLSAVGPEAGALWVCAALGDGDREAVRQGVAEPGVRMLGIDPDVFHDAYNGVANSVLWFVHHMLYDIPVAPVFDAAFRRQWAAYETYNRAFADALADGAAEGAAVLVQDYHLCLVPGMLRERRPDLRISHFTHTPWAPPEYFRLLPDDIAAALLRGLLGADRVGFHTRRWAEAFAGCCREVLGGEADVAFAGEEARGERTTWVDVHALGADADFLRERSRRPDVAERMAALREQIGGADREVVVRVDRTELSKNIVRGLLAYRRLLEARPEWRGRVVKLAFAYPSRQDLAVYRDYTAEVRRLAAEINEAYGTDGWQPVVLHVEDDFARSLAAYRLADVALVNPLRDGMNLVAKEIPVVSDDGCALVLSREAGAYADLAEDALVVHPYDVEATADALHAALTMPRDERARRTKRLAAAATALPPQAWFLAQLDALRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N667</accession>
    <name>A0A0F7N667_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">LPXTG-domain-containing protein cell wall anchor domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_12020</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016174.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_12020"/>
    <dbReference type="EnsemblBacteria" id="AKH82839">
        <property type="protein sequence ID" value="AKH82839"/>
        <property type="gene ID" value="AA958_12020"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_12020"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2529"/>
    <dbReference type="OrthoDB" id="1955244at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519244" evidence="3">
        <location>
            <begin position="28"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH82839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="231" mass="23752" checksum="7D82D07848FC07AF" modified="2015-07-22" version="1">MRTIASVGAVAAAAAASLLFAAAPAPAANGDNGTVKIHDAATGEELRKNEPKVCEFYLDAFGFDAGQQVTWEIVGWKPTGDNKTVADEGEIVLDGEGHGRTEDMTLPDGHYKLFWNWEGENGAAKHKVFWTECEDSESPDPDTPSDTPSDDSSQAAEEPGRPGKPGEDGEQGADATPSASNAPGAQGGGDDESGGLAATGASVTGISIASAILLGAGGYLVLRRRGMGRQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N679</accession>
    <name>A0A0F7N679_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_12385</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016233.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH82898">
        <property type="protein sequence ID" value="AKH82898"/>
        <property type="gene ID" value="AA958_12385"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_12385"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2602"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519111" evidence="2">
        <location>
            <begin position="34"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH82898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="216" mass="20988" checksum="81CEF944A5FA741F" modified="2015-07-22" version="1">MPAFEPLRPARGARLRRALASRRRLLAALLAMAAAALAAAPRGDTEDPPPAAAPDGAEREGPGEVTGPAGEARDGGGSGEVLAPVRIADAGVAGLLAPGDVVDVLAVDADDGGPARVVARGARVAEIPGAAGAPDAEQGADAPGAAETAGAMGSPESREAPDASDLAEIPEVELPSGAAGLTGWEDGTLVVLSVPRSTATALAGAAAGERLAVTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6J2</accession>
    <name>A0A0F7N6J2_9ACTN</name>
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        <submittedName>
            <fullName evidence="2">DegV domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_09425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015757.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_09425"/>
    <dbReference type="EnsemblBacteria" id="AKH82412">
        <property type="protein sequence ID" value="AKH82412"/>
        <property type="gene ID" value="AA958_09425"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_09425"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1990"/>
    <dbReference type="OrthoDB" id="1288126at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003797">
        <property type="entry name" value="DegV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043168">
        <property type="entry name" value="DegV_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02645">
        <property type="entry name" value="DegV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00762">
        <property type="entry name" value="DegV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51482">
        <property type="entry name" value="DEGV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="284" mass="29507" checksum="E6BCBC152A2DA688" modified="2015-07-22" version="1">MSSDVAIVADSTAYLPPEAMRRHGIISVPLTVVLGDRALEEGTEISARSLAEALRKRNPVTTSRPGPALFAATYRKAAEAGARGIVSLHLSAEFSGTYDAAVLAAKEAPVPVRVVDTRMVAMALGFCAIAAAEAAEAGGTVDDAVEAAERRAAGTSAFFYVDTLDYLRRGGRIGTAQALLGSALAVKPLLRLDGGRIELLEKVRTASRAILRLEELVLERAAEGPVDVAVHHLAAAERAAELADRLRERVPGLGELHLSEVGAVIGAHTGPGLLGAVVSRRGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N709</accession>
    <name>A0A0F7N709_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ricin B-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_14110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH83178">
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        <property type="gene ID" value="AA958_14110"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_14110"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2970"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14200">
        <property type="entry name" value="RicinB_lectin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="SSF50370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ricin B-type lectin" evidence="1">
        <location>
            <begin position="15"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="138" mass="15004" checksum="5458402B152FAB25" modified="2015-07-22" version="1">MDIGAAAGDQPYEADCDGGRSQQWELLVSLPPVQEVRIRNHATGMCLTHSGTDADGAPVSQRPGACLSDASTAHWKYFLEDDDKVVFTQRDSSGQFLGLDDWRAAAEGRPHAPDIGTTANYEATPSLRFRYRGPAFGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N761</accession>
    <name>A0A0F7N761_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_10880</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015987.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH82647">
        <property type="protein sequence ID" value="AKH82647"/>
        <property type="gene ID" value="AA958_10880"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_10880"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2289"/>
    <dbReference type="OrthoDB" id="1884964at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="136"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="285"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="325"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH82647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="376" mass="38427" checksum="82797AA165223E6D" modified="2015-07-22" version="1">MTDLEIHQPDADGTGGGPADSASKTKADADADGGGGGNGPGRQREGGRRGTEAAEAADVTEAAEAAEAADVTEAAETAETAETAETTDVAATGPVADTAVVAGTAPVAGTAPVADIDATGPAGPVAEAAPPPARRWVLWGAGGLTVLVLAADLLTRGFNHFEPIPGVRRMVNVDLEANLATWWNSTLLLAVAGVALGAALLSGRGARPSRLSWLGFSAATATLSIDETVSLHERLGEVGKSWKDTAGVALPSHAWVLPGAILAVAGIVVAVVWARRLPRDLRFGLLGALGVYLGGALVVEAFNGWAHKNDHSLTLMLGTLVEEGLEMGACVVALAVLGRYVVVEHDPVTGRISAFLRYERTRHPERAVTPPVRQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7D6</accession>
    <name>A0A0F7N7D6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_14940</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016614.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH83299">
        <property type="protein sequence ID" value="AKH83299"/>
        <property type="gene ID" value="AA958_14940"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_14940"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3148"/>
    <dbReference type="OrthoDB" id="498436at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="235"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="314"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="390"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH83299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="419" mass="43031" checksum="CB454F9AC875E5E2" modified="2015-07-22" version="1">MARKLRAGGAGGAGDPPSPTPLWTTDFRLFFTARTTSLLGDAMLPVAITAAVLGAGYGASGVGYALAALVAPFAALIIFGGVLSDRFGARRLMVLSDAARLVFQMALALLFLVGTPPLWQILVLLAFVGAGSALFQPGVASITPRVARDVQKANATLRIAESVTLVLGPSLAGLLLAVSSPAVVVALDAVTYAVSGACLFALRAVPMGPGKAAREGAPSFRADLVEGWREFSARTWLWSVIVVFMLWQLAGAGPTTTLGNSTLVTDYGASTFGLVMSSLGAGSVLGGLVAIRLRPRHPLRAGALSMTLWALMPLGVALGLSAPLVALCYGVSGIGAAFWIVMFHTSVQTHVPQDVLGRVHAYDAAGSLVMKPVGQAAAGPLAGVVGTVPLLFVSATMAVLTCLLLLAIPAVRGLRRVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7M2</accession>
    <name>A0A0F7N7M2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">ATP-dependent Clp protease proteolytic subunit</fullName>
            <ecNumber evidence="5">3.4.21.92</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Endopeptidase Clp</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">clpP</name>
        <name evidence="9" type="ORF">AA958_15430</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 7">Belongs to the peptidase S14 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.92" evidence="5"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016681.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_15430"/>
    <dbReference type="EnsemblBacteria" id="AKH83369">
        <property type="protein sequence ID" value="AKH83369"/>
        <property type="gene ID" value="AA958_15430"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_15430"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3247"/>
    <dbReference type="OrthoDB" id="1728970at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07017">
        <property type="entry name" value="S14_ClpP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00444">
        <property type="entry name" value="ClpP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001907">
        <property type="entry name" value="ClpP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023562">
        <property type="entry name" value="ClpP/TepA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033135">
        <property type="entry name" value="ClpP_His_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381">
        <property type="entry name" value="PTHR10381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00574">
        <property type="entry name" value="CLP_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00127">
        <property type="entry name" value="CLPPROTEASEP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00382">
        <property type="entry name" value="CLP_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 9" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0720">Serine protease</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 6">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH83369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="215" mass="23171" checksum="2E4332959E93F0B6" modified="2015-07-22" version="1">MTPPARTALTPRAEEEDSPPPSRFDDHLAAQLLGQRIVLLGTEVTDASANRVCAQLLLLSAEDPRTDIALYVNSPGGSVHAGLAIYDTMRLIPNDVATLAMGFAASMGQFLLTVGTKGKRFALPHARIMMHQPSAGIGGSAADIEIQADNLAYSKTLMERLLAEHTGQDQATISRDGDRDRWFTAEQAKEYGMVDQVVESLADIRPAGSKRRMGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-10-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7N0</accession>
    <name>A0A0F7N7N0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_15740</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016730.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH83418">
        <property type="protein sequence ID" value="AKH83418"/>
        <property type="gene ID" value="AA958_15740"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_15740"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3317"/>
    <dbReference type="OrthoDB" id="990666at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH83418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="304" mass="32228" checksum="43D04D3E0E49414D" modified="2015-07-22" version="1">MTLDDLRVFVAVCRAGSLSAVARELGCTQSAVSQHVKRLEREVGLSLVERHPRGVVPTHAGELLRGAAAEGIGGVDHALRRLRDLARGDGGSVRVTTGATTVRHFMSAAVVAFRERYPQVSLEFQTENSSRGCVAALAAGGADLAWITIAAPVRGVELRRAAELRWVLAVREGDPLAERSAVGAADLAAVRLIGLPANSSSRAHLEAWFAESGVRLPAFDTSVADWDTAILLAELGLGYAVVPELPGWRDGRHPGVRLVPVPDLPPLWAGWAVRRWAALSPLARAFADMVAAGVETEVETEGAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-10-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7P8</accession>
    <name>A0A0F7N7P8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Lysine transporter LysE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_15745</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016731.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH83419">
        <property type="protein sequence ID" value="AKH83419"/>
        <property type="gene ID" value="AA958_15745"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_15745"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3318"/>
    <dbReference type="OrthoDB" id="1927576at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001123">
        <property type="entry name" value="LeuE-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30086">
        <property type="entry name" value="PTHR30086"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01810">
        <property type="entry name" value="LysE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006324">
        <property type="entry name" value="LeuE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH83419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="203" mass="21045" checksum="0B6229FEA709A454" modified="2015-07-22" version="1">MSIAFLLTTLVVVVTPGTGVVYTLAAGLSHGRRASVVAAFACTLGTVPHVVATVTGLAALLHASAVAFEVVKYLGVAYLLYMAWSTLRAKEALVVEDAAAAGPQPVRRVIVSGVLLNVLNPKLTMFFVAFLPQFVPAGQEGSVAAMLRLSAVFMGMTFAVFVAYGLCAAAVRGHVLGRPRVMAGIRRVFAVSFLGLGAKLAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7R8</accession>
    <name>A0A0F7N7R8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_19930</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017366.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_19930"/>
    <dbReference type="EnsemblBacteria" id="AKH84076">
        <property type="protein sequence ID" value="AKH84076"/>
        <property type="gene ID" value="AA958_19930"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_19930"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4199"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="1">
        <location>
            <begin position="18"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="205"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH84076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="419" mass="44843" checksum="348EBC1DC2D4DA3F" modified="2015-07-22" version="1">MGPGPTWRGQRTESGPVIDYEAVFQAMPTAAALFTTDLAYLDANDAYCSTSGRSRSQLIGRYVFDVFPDNPDNPEASGTRNLAASLRRVAATGQRDAMALQRYDVESPDQPGVWEERYWSLVNAPVFAPDGTVALLLHRVEEVTELVRARGGDERTQVLEADLYARGRELQELNERLRLAHAREHEVALQLQDAMLPAPNPLGHHRAAVRYRPAVASLNVCGDWYDIADRPGGDGTVVAVGDVVGHGLRAAGVMGQLRSALSAASLVAGGPAQALEVLGRYARNVDAAATATAAAVFIDWAGCSLTYSSAGHLPPALWRPDGTVTYLAQATDPPLGVRPERSARPEARVAFTEGCALVLYTDGLVERRNEDIDVGLARLADSIARHGAADPEQLADALLADLIPPTGLTDDTALVVVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7V6</accession>
    <name>A0A0F7N7V6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_12280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016217.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH82882">
        <property type="protein sequence ID" value="AKH82882"/>
        <property type="gene ID" value="AA958_12280"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_12280"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2582"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH82882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="551" mass="60505" checksum="07211FFB099527C7" modified="2015-07-22" version="1">MSVLHLDAALRRLSQPEGASPDELRADLDAVVHHLRSAHANGIRAAQASSFDILSENVKVLILQQFFHHSQAGSHQTDYDREMVVQLLSDWFSIKIDESPFAEENAANSTTRMHPGRSGAEPVTLTFGDTEICLIMSDEVCSAAHELVRSVTHDAVLTTDATSPPCELAEFVPLWLKDRSREARDLYIDNAAGSGPDHPIARYFTSIETALATAGVRLLEGSTEMAIIANGDGLRYHRDRLVNQYARLENAPETRGTYEVIQYLTLIDWDMQPECMSGTALDHPNGDRYLFALWPGEVVGLFFSEPAQFPGPMMMPYHCALPVFDRSAARTTGTAKGKRFSALVRGIAKTDQVRALREGAQRIAVNEVREEHEGVRRYANGVSVRTPESLPETALVPVAAPDRVSEGLSLVELDAEANRELASHACVGDTGGVRLFRLEKHGEGFSDLATAMREFVGPDTEISVINRSHRGGQSETCYPVAFDATQQGLPWIQLCRAQPGTVFTVPPAARDALRMPPTDDILHRPALLDSFHSLSSARPRLALVVDVFVKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N864</accession>
    <name>A0A0F7N864_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-ketoacyl-ACP reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_17095</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
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            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016947.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_17095"/>
    <dbReference type="EnsemblBacteria" id="AKH83643">
        <property type="protein sequence ID" value="AKH83643"/>
        <property type="gene ID" value="AA958_17095"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_17095"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3595"/>
    <dbReference type="OrthoDB" id="1821409at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH83643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="239" mass="24988" checksum="AA2874A373672C79" modified="2015-07-22" version="1">MLLNGRTALVTGGSRGIGRAIVTRLARDGARVVFTYKENETAAAEVVREVPGTEAVRADQERPDALAHAFAPVRDGLDILVNNAAVNPRLPLAELTAAEFDRVLTANARFGVLAMREAAALMPDGGRIVNISTLNTVVPAPGHALYCASKAVLEQFTQVAARELGPRGITVNTVSPGATETALLHATNPPEALTQTAAMTALQRLGRPEDIAAVVSFLTGPDAAWITGQNLRATGGLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N899</accession>
    <name>A0A0F7N899_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_17140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH83649">
        <property type="protein sequence ID" value="AKH83649"/>
        <property type="gene ID" value="AA958_17140"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_17140"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3604"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519166" evidence="2">
        <location>
            <begin position="27"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH83649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="222" mass="21735" checksum="EAA851E793357FC9" modified="2015-07-22" version="1">MRRLRLLGYVLVLLGLLAGAASCADAGRSGTAGAHGLVLRADAPQTDVLATLRPDALRGDDPRADASPADRLPADAPPGDALPADGLRAGVPPGDGLPADPARAVALRPGDAPQPDGPPGDTPRPHGPPRGPLPAGVLSAGAAPLPLDCTSVHAPGAPAGECPAASERAPVASLSGPAFSPPPGTAPSYVPSAAAVADCGLAPAPPGALRTPDLHQLQVQRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8L1</accession>
    <name>A0A0F7N8L1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Inorganic phosphate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_18050</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017094.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_18050"/>
    <dbReference type="EnsemblBacteria" id="AKH83794">
        <property type="protein sequence ID" value="AKH83794"/>
        <property type="gene ID" value="AA958_18050"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_18050"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3796"/>
    <dbReference type="OrthoDB" id="1329125at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001204">
        <property type="entry name" value="Phos_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101">
        <property type="entry name" value="PTHR11101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01384">
        <property type="entry name" value="PHO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="305"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH83794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="332" mass="35382" checksum="0926A461137DD298" modified="2015-07-22" version="1">MDTFALVVTIGVALFFTYTNGFHDSANAIATSVSTRALTPRAALLMAAVMNFAGAFLGSGVAKTVSEGLIETPHGSHGMWILFAALVGAITWNMVTWYFGLPSSSSHALFGGMVGAALAASSKVFWSGVLEKIIIPMFVSPIVGLCVGYLVMCAIMWMFRRSTPRRAQRGFRVAQTVSAAAMALGHGLQDAQKTMGIVVLALVIADVEDEGDAIPWWVKVMCALMLSLGTYAGGWRIMRTLGRRIIDLQPPQGFAAETTAAGIMYSASFMFHAPISTTHVITSAIMGVGATKRVKAVRWGVAKNIVMGWFVTMPAAAGVAAAVYWLVHFAFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N905</accession>
    <name>A0A0F7N905_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_19490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_19490"/>
    <dbReference type="EnsemblBacteria" id="AKH83998">
        <property type="protein sequence ID" value="AKH83998"/>
        <property type="gene ID" value="AA958_19490"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_19490"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4102"/>
    <dbReference type="OrthoDB" id="1448212at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="227" mass="25281" checksum="F288784EB1E7F604" modified="2015-07-22" version="1">MTQLASDDEEDVPEWADRVKATVAGEVRRRRRAMGWSAQDLADRSAQLGHPIPRNVIANMESGRRATLPLVDVMVLAAALETYPVCLIFPVGYVERVQELPFQELVPTWEALQRFTGEEEVATHDFGLVPDFDYHASLVRGALASAEESESSRFAAKTATSRAQREEAERKHNESEDRLIAAKSQLRSLRHEIRESGAVPPSLPHALQDVEPPEHTALPSSDGRPER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N962</accession>
    <name>A0A0F7N962_9ACTN</name>
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        <submittedName>
            <fullName evidence="2">Copper homeostasis protein CutC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_19840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CutC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_19840"/>
    <dbReference type="EnsemblBacteria" id="AKH84058">
        <property type="protein sequence ID" value="AKH84058"/>
        <property type="gene ID" value="AA958_19840"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_19840"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4181"/>
    <dbReference type="OrthoDB" id="1728422at2"/>
    <dbReference type="Proteomes" id="UP000034283">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF03932">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF110395"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="228" mass="23489" checksum="44120063781F4C91" modified="2015-07-22" version="1">MLLEVIALNAADAAAAEAGGADRLELVTDMAADGLTPSRETVAAVRAAVEIPVRVMLRAEDGFAAGDAEALAARARALRAEGAEEFVLGFLDEAGGPDLATVGRLLEAVGDGCRWTFHRAIDRAADRDTLRKQLAGLPGLDTYLTAGSAKGVADGLAVLVAEAARATARQPGYEARIMAGGGLTTAHVPRLRAAGLDAFHVGGAVRPEGWSGPVSPRSVAEWRTLLDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N966</accession>
    <name>A0A0F7N966_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_19295</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_19295"/>
    <dbReference type="EnsemblBacteria" id="AKH83974">
        <property type="protein sequence ID" value="AKH83974"/>
        <property type="gene ID" value="AA958_19295"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_19295"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH83974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="194" mass="20884" checksum="40B817E442819BA4" modified="2015-07-22" version="1">MIVDQFEEVFTLCRDPAERARFLDMLLTARRPESRLRVLLAVRADFYGRCAEHRELAEALRDANVLVGPMTAGELRDAIVKPAAADGLTVERALTAHLVEEVADAPGGLPLLSHVLLETWRRRRGKVLTMAGYQAAGGLGGAIATTAEEVYATFTEGQKAVHQHPAVQHASSAAVRACTRRVAGPAGTPNVPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-08-12" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9D1</accession>
    <name>A0A0F7N9D1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ArsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_26235</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AHA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018386.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH85145">
        <property type="protein sequence ID" value="AKH85145"/>
        <property type="gene ID" value="AA958_26235"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_26235"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5522"/>
    <dbReference type="OrthoDB" id="1498264at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08327">
        <property type="entry name" value="AHSA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH85145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="263" mass="29734" checksum="F1E8D1F6AB85E11D" modified="2015-07-22" version="1">MDDVFRALADGSRRELLDRLNERNGQTLRELCAGLEMSRQAVSKHLAVLESAGLVTAVRHGREKLHYLNPVPIHEVADRWIGRYERGRLTALSALKQALEGNPLKKPAFVYTIYIETTAEKLYEALTTPEFLKQYHGGWAPRSDWQAGSTVYWPMEENGEPLDLGQRVLVAEPGRRLVYTWHTLQPMHQEMLGMSDAEFAEASKERSQVAFDIEPAEIPKLGVKLTITHDHFDSAESRMLESVSGGWVMLASQLKSILERQPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9P7</accession>
    <name>A0A0F7N9P7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_26935</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018507.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_26935"/>
    <dbReference type="EnsemblBacteria" id="AKH85270">
        <property type="protein sequence ID" value="AKH85270"/>
        <property type="gene ID" value="AA958_26935"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_26935"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5667"/>
    <dbReference type="OrthoDB" id="1020672at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="2"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="124"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="124"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH85270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="217" mass="23911" checksum="A0A59F4C75F9C56E" modified="2015-07-22" version="1">MRVLVVEDEQLLADAVATGLRREAMAVDVVYDGAAAIDRIELNDYDVVVLDRDLPLVHGDDVCSRVVELGLPTRVLMLTAAGDVRDRVEGLELGADDYLPKPFAFSELTARVRALGRRSTQALPPVLERSGIKLDPGRREVYRDGRLVQLAPKEFAVLEVLLRAEGGVVSAEQLLEKAWDENTDPFTNVVRVTVMTLRRKLGEPPVIITVPGSGYRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9Q1</accession>
    <name>A0A0F7N9Q1_9ACTN</name>
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        <submittedName>
            <fullName evidence="1">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_24025</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84771.1"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_24025"/>
    <dbReference type="EnsemblBacteria" id="AKH84771">
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        <property type="gene ID" value="AA958_24025"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_24025"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5063"/>
    <dbReference type="OrthoDB" id="1384440at2"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0016491">
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11583">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH84771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="309" mass="35455" checksum="2C604BC6293D09D2" modified="2015-07-22" version="1">MTTTTGHLALTDALGPLKDREKVAERLLAASEKHSFDPDRELDWDAPVEEGKWFWPPELVSLYDTPMWRRMSEEQRRELARLEAASLASLGIWFEIILMQLLVRHIYDKPVTSNHVRYALTEIADECRHSMMFARMITKGGAEPYPVSRFHHNLARVLKTVSTTPGSFTATLLGEEILDWMQRLVFPDERVQTLVRGVTRIHVVEEARHVRYAREELRRQMLTAPRWERNVTRLTSGEAARVFSVSFVNPQVYTDAGLNRAEAVAQVKASPHRREVMQTGAKRLTDFLDDIGVLRGVGRRLWRSSGLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NA01</accession>
    <name>A0A0F7NA01_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GCN5 family acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_24545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="444103.AA958_24545"/>
    <dbReference type="EnsemblBacteria" id="AKH84851">
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        <property type="gene ID" value="AA958_24545"/>
    </dbReference>
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    <dbReference type="PATRIC" id="fig|444103.5.peg.5171"/>
    <dbReference type="OrthoDB" id="1538300at2"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0008080">
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="23"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="186" mass="19933" checksum="191067AEF241F2A0" modified="2015-07-22" version="1">MLRGTKVGLRARHADDIPILQADLYDDVVTGSRAQATPWRPIAAASEDNPLLVDDKAEGTVPFSVVELEGGELVGTASLWGIDAHHRSAHVGLGLMPYARGKGYGTDIVAALCHYGFVVRGLHRLQIETLADNAAMLRAAERNGFVREGVLRSSAWVLGTFLDEVVLGLLAPDWRPDAAARPDDGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NA04</accession>
    <name>A0A0F7NA04_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_24580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018108.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH84856">
        <property type="protein sequence ID" value="AKH84856"/>
        <property type="gene ID" value="AA958_24580"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_24580"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5180"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH84856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="92" mass="9669" checksum="796F0B59BA43E047" modified="2015-07-22" version="1">MTNDAGPGEIRGSRASALLKCLHPFRFLLVRVQEDTEGEHAVYPFLLSLASAAFHSGEEIGLRAADVALPEEVLGGLLVRGKKGAGPGTART</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NA38</accession>
    <name>A0A0F7NA38_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ATP synthase gamma chain</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP synthase F1 sector gamma subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">F-ATPase gamma subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">atpG</name>
        <name evidence="12" type="ORF">AA958_24870</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the ATPase gamma chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018152.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_24870"/>
    <dbReference type="EnsemblBacteria" id="AKH84901">
        <property type="protein sequence ID" value="AKH84901"/>
        <property type="gene ID" value="AA958_24870"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_24870"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5243"/>
    <dbReference type="OrthoDB" id="1701531at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042777">
        <property type="term" value="P:proton motive force-driven plasma membrane ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12151">
        <property type="entry name" value="F1-ATPase_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00815">
        <property type="entry name" value="ATP_synth_gamma_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035968">
        <property type="entry name" value="ATP_synth_F1_ATPase_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000131">
        <property type="entry name" value="ATP_synth_F1_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023632">
        <property type="entry name" value="ATP_synth_F1_gsu_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11693">
        <property type="entry name" value="PTHR11693"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00231">
        <property type="entry name" value="ATP-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00126">
        <property type="entry name" value="ATPASEGAMMA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52943">
        <property type="entry name" value="SSF52943"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01146">
        <property type="entry name" value="ATPsyn_F1gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00153">
        <property type="entry name" value="ATPASE_GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0139">CF(1)</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 9" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="5 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519300" description="ATP synthase gamma chain" evidence="11">
        <location>
            <begin position="25"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="264"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AKH84901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="313" mass="34235" checksum="F0401CA18B5812AD" modified="2015-07-22" version="1">MGAQMRVYKRRIRSVSATKKITKAMEMIAASRVVKAQRQVAASTPYATELTSAVTAVAAGSETKHPLTTEVERPVRAAVLMITSDRGLAGGYNSNAIKQTETLTNRLTGEGRQVDHFIVGRKGVSYFGFRERPVAESWTGFTDNPTYADAKRVAAPLIEALSKETSEGGVDEIHIVYTEFHSMMTQTAMDRRLLPIVFEKTAADSAEVFEEARKKEQEYHALYDFEPSADGVLDALLPRYVESRIYNALLQSAASKHAATRRAMKSATDNAEELIKSLTRLANQARQAEITQEISEIVGGANALADASAGSDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NA58</accession>
    <name>A0A0F7NA58_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Bifunctional protein FolD</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="6">Methylenetetrahydrofolate dehydrogenase</fullName>
                <ecNumber evidence="6">1.5.1.5</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="6">Methenyltetrahydrofolate cyclohydrolase</fullName>
                <ecNumber evidence="6">3.5.4.9</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="6" type="primary">folD</name>
        <name evidence="9" type="ORF">AA958_21740</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADP(+) = 5,10-methenyltetrahydrofolate + NADPH</text>
            <dbReference type="Rhea" id="RHEA:22812"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>5,10-methenyltetrahydrofolate + H2O = (6S)-10-formyltetrahydrofolate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="EC" id="3.5.4.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.5" evidence="6"/>
    <dbReference type="EC" id="3.5.4.9" evidence="6"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017645.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_21740"/>
    <dbReference type="EnsemblBacteria" id="AKH84383">
        <property type="protein sequence ID" value="AKH84383"/>
        <property type="gene ID" value="AA958_21740"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_21740"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4579"/>
    <dbReference type="OrthoDB" id="1449514at2"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004477">
        <property type="term" value="F:methenyltetrahydrofolate cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004488">
        <property type="term" value="F:methylenetetrahydrofolate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01080">
        <property type="entry name" value="NAD_bind_m-THF_DH_Cyclohyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01576">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000672">
        <property type="entry name" value="THF_DH/CycHdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020630">
        <property type="entry name" value="THF_DH/CycHdrlase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020631">
        <property type="entry name" value="THF_DH/CycHdrlase_NAD-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00763">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02882">
        <property type="entry name" value="THF_DHG_CYH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00085">
        <property type="entry name" value="THFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="5 6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3 6" id="KW-0521">NADP</keyword>
    <keyword evidence="1 6" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 6" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THF_DHG_CYH" evidence="7">
        <location>
            <begin position="6"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="THF_DHG_CYH_C" evidence="8">
        <location>
            <begin position="123"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="165"/>
            <end position="167"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH84383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="314" mass="31959" checksum="D7126C534F3A5C3C" modified="2015-07-22" version="1">MTAQILDGRATAAAIKSELATRVQALKGRGVTPGLGTLLVGDDPGSQKYVAGKHRDCAEIGIASIQRELPATATQEQIEAVVRELNEDPDCTGYIVQLPLPRDIDENRVLELIDPAKDADGLHPTNLGRLVLNEPAPLPCTPNGVIRLLRQFGVELNGAHVVVVGRGVTIGRSLPLMLTRKSENATVTQCHTGTRDLAGHLRQADIVVAAAGSPHLIKPADIRPGAAVLDVGVSRDEHGKIVGDVHPGVADVAGWLSPNPGGVGPMTRAMLLVNVVEAAEAAAGVSGAGGGSGISGTAGAAGTSGMGTAAPAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NA86</accession>
    <name>A0A0F7NA86_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_25210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018212.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_25210"/>
    <dbReference type="EnsemblBacteria" id="AKH84961">
        <property type="protein sequence ID" value="AKH84961"/>
        <property type="gene ID" value="AA958_25210"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_25210"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5313"/>
    <dbReference type="OrthoDB" id="1753304at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038721">
        <property type="entry name" value="IS701-like_DDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13546">
        <property type="entry name" value="DDE_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_5" evidence="2">
        <location>
            <begin position="22"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="438"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH84961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="485" mass="54686" checksum="CA4F42CA8FDCAA59" modified="2015-07-22" version="1">MSVVCRDVRREAFAEASRFRGEFYECLTARRDELFELTDALLCVDGPVTSPVDLTMVPEHRRGHGALYGALNRGGIDVERLRTLLAGLPLPRFESGRLVLAVDVSPWLRSDAPCSADRLFCHVYGRAKSASQFIPGWPYSFVAVLEPGATSWTSILDVVRLGPEDDATAVTAAQLRAVAERLISAGQWTPGDPDITIVMDAGYDVTRLAWVLRDLPVELVGRIRSDRVMRLPKPSPEEYSLAYPQGGRPPKHGKEFRFAKPETWPEAAITTITDTANYGKAEAQAWDRVHPRLTHRSAWLEHDGELPVVEGTLVRLKVEHLSKEREAPPVWLWSSKTGAAPTDVDLWWQVFLRRFDLEHTFRFGKQILGWTTPKVRTPEAADRWTWLVVVAHTQLRLARPLAADLRRPWEKPTKPERLTPARVRRGFRNIRAHLLCPARVPQPRGTGPGRPPGTKNRRPAPRYDVGKTVRRPETLKAIGRPGRSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAJ3</accession>
    <name>A0A0F7NAJ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_22525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017772.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_22525"/>
    <dbReference type="EnsemblBacteria" id="AKH84513">
        <property type="protein sequence ID" value="AKH84513"/>
        <property type="gene ID" value="AA958_22525"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_22525"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4740"/>
    <dbReference type="OrthoDB" id="1434838at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="12"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="290" mass="30223" checksum="9FDAF2C97A7DC2F9" modified="2015-07-22" version="1">MTRLATVFIPQFPPEQLRAVARAADESGIDELWVWEDCFYESGVATAAAVLAWTERVHVAIGILPVPLRNVALVAMEAATLHRLFPGRVTLGVGHGVQSWMGQVGARAASPLTLLREHLTALRALLAGEKVTVDGRYVTLDGVELAWPPAAAPPVFSGGTGPKTLRLTGESADGTILAGGASPEVVQEAAETVRAGREAAGRGGEHPLVASILVATGPGAERRLAEDARRMGWDPAAEAHVAGDAAAVAAAVDRWAAAGATTVVLQPTADEPDPVAFVRWVAEEVRPLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAJ4</accession>
    <name>A0A0F7NAJ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_17610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017026.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_17610"/>
    <dbReference type="EnsemblBacteria" id="AKH83722">
        <property type="protein sequence ID" value="AKH83722"/>
        <property type="gene ID" value="AA958_17610"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_17610"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3707"/>
    <dbReference type="OrthoDB" id="1623808at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05729">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NACHT" evidence="1">
        <location>
            <begin position="274"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="1080" mass="116926" checksum="A6298EA18CF28719" modified="2015-07-22" version="1">MEPAAVGARLASAVVAPLVRRLFRSEGPGAGLAGRPVRMAALVSFRGERRELDEDGLRKLAGTLVRRALDGPGGEPAPVPAGEAEAVAGALARSLTALGDLDLDDVQAVQLGPEALARRLRRAAAQRGGDPVRELSADAASFHDTLLDTACLHILHFFSQRSTFVARTLVEQSRRQADQIARLDALIARTPLPAAQDAAFEREYFAYAAKKHGRLTIYGVDLADSPAKWPLDVAYLRLEAAASTQAAPSPFPFDDTDPLSDPVLPADQALAAYERVLLRGAAGSGKTTLVQWLALSATRAGSGAEHSMDYLAGRVPFVLPLRTLTRHGQRLPAPRDFLSATGSPLAGAQPDGWEHRVLTARRGLLLVDGIDEVPRAERDRTRRWLSDLADAYPGNRWLVTSRPSAVGEDWLAAEGFTELTLAPMRPADLTRFIARWHEAVRAGAVRTGAPAADDAQLTAYEQQLTAAVRHTSDLGRLATNPLMCGLMCALNRARRGYLPRGRKELYEAALSMLLSRRDRERDMAVPDLREEPQLQVLQRLAYWLIRNGRTELDRARAESLVAAALPAVPEVAALGDAAAVLEHFRDRSGLLREPAPGAVDFVHRTFQDYLGARAAVEEGDIGVLAAHAADDQWEDVIRMAVAQARPREREEILRELLAAAERREGVEGVRIRLLAAACLEHAAELAPGVREAVERATEALIPPKTPVEARALGAAGPLVLDLLPGPEEAGEEAGDESAALIAAAASHVDSDRAIAFLARYADHPSLGVRSQLVWAWHRFDTEEYADEVIARLDPDGLYFTVTSDAELRALRRLGGRPMVDVRGPLDPVGLQDGLAATRLTDLIVRNQPRLMDLAFLRGQSELRYLRLNECADLYDASALAGLPLTVLILDTVPGLVESVPGLLANHPQLEALSLSPERRRPLDLDTLPALPALSTLNLLTARTAGLHPLARHPGLRHVYLGWRHEATAYDWPALAALPLLEGLRCRPDLLTVAPADATLPGITFLGLVGDRPADELDLSRFPSLFPRLDHLVLDLPPGSGPLELSPLAALGTLREVSLRPHMRNLHAGLPPRVEVTYLAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAQ2</accession>
    <name>A0A0F7NAQ2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4097 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_17945</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017079.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_17945"/>
    <dbReference type="EnsemblBacteria" id="AKH83777">
        <property type="protein sequence ID" value="AKH83777"/>
        <property type="gene ID" value="AA958_17945"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_17945"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3778"/>
    <dbReference type="OrthoDB" id="1508494at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025164">
        <property type="entry name" value="DUF4097"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13349">
        <property type="entry name" value="DUF4097"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519912" description="DUF4097 domain-containing protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4097" evidence="3">
        <location>
            <begin position="46"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH83777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="272" mass="28457" checksum="637D0A886C0F878C" modified="2015-07-22" version="1">MKPKPAALAAPALALALAAVATACTQAVGDGKAEHRTFRIGADATTLTMDADDTAVELVPVDREDGEIDVTRWFKAEKWNGDVGTTWSVDGDTLRFRTKCSGVVVSCDSRYRVEVPRNLDVEIDGSDGRIEANGFDTRLDIRSGDGAVEVADAGGPLNIEARDGSVRIDGAAGPVDLDARDGSVRATGLTTTRVTAALGDGSLHLGFTETPDQVTAETRDGGLTLEVPKAPYRVSTDVRDGSTDVTVPRDPASPHRIKATTGDGSVTIRPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAW5</accession>
    <name>A0A0F7NAW5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ATP-dependent DNA helicase RecQ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_26730</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018468.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_26730"/>
    <dbReference type="EnsemblBacteria" id="AKH85231">
        <property type="protein sequence ID" value="AKH85231"/>
        <property type="gene ID" value="AA958_26730"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_26730"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5624"/>
    <dbReference type="OrthoDB" id="54580at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004589">
        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00614">
        <property type="entry name" value="recQ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="36"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="240"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH85231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="719" mass="76473" checksum="8D93DCE863D1376E" modified="2015-07-22" version="1">MDDQELRAEADAVLAGLVGDAGGPARLREDQWQAVDALVRERRRALVVQRTGWGKSAVYFVATALLRRRGAGPTVIVSPLLALMRNQVEAAARAGIRARTINSANPEEWGAIHEEVERGETDVLLVSPERLNSVDFRDRLLPELAATTGLLVVDEAHCISDWGHDFRPDYRRLRAMLADLPEGVPVLATTATANARVTADVAEQLGTGGGEALVLRGPLDRESLRLGVVRLPDAAHRLAWLAEHLGELPGSGIVYALTVAAAEEAAAFLRQRGFPVASYTGRTENADRLQAEEDLLANRVKALVATSALGMGFDKPDLGFVVHLGSPSSPIAYYQQVGRAGRGVDHADVLLLPGREDEAIWRYFADTAFPPEAQVRQTLAALADAGRPLSVPALEAAVDLRRTRLETMLKVLDVDGAVRRVKGGWTATGRAWEYDTERYAWVARQRAAEQQAMRDYVSTPGCRMEFLRAQLDDEGAEPCGRCDNCAGPWIGAGVSAEALTGAEKELDRPGTEIEPRRMWPTGMAALGIDLKGRIPAGEQGATGRALGRLSDIGWGNRLRPLLAPHTPDAPVPDDVLRAAVGVLADWARSPGGWAAGGPDAPARPVGVVAVPSTSRPLLVDSLARGIATVGRLPYLGTLAYADPDGGHAVRRSNSAQRLATLTGTFTVSGDLAAALAGNPGPVLLVDDYTDSGWTLAVASRLLRRAGAGAVLPLVLAANG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NB77</accession>
    <name>A0A0F7NB77_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_23705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="His_kinase_dom"/>
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        <property type="entry name" value="PAS-like_dom_sf"/>
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        <property type="entry name" value="PdtaS_GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011495">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07568">
        <property type="entry name" value="HisKA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histidine kinase" evidence="1">
        <location>
            <begin position="391"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="493" mass="53979" checksum="CF8249C8DBEBE7F5" modified="2015-07-22" version="1">MNELVRRHTALSETDLEWLHLLVSEWQLLADLSFADLVLWVPTVDGARYVSVAQMRPNTGPTSYQDDMVGHTVPRGRRPMLDAALDEGRIVREGDPEWREEVPVRIESIPVRRESRVLGVIARNTNLLTVRTPSRLELTYLQSASDLAQMIAAGAFPYPGQQGDTETSPRVGDGLIRLDAEGIVQYASPNALSAYHRLGQAADLVGRHLGQATSELAVSKEPVDEALVKLASGWAPREAEVEGNGGVIQLRAIPLKPRGTRIGSLVLLRDVTEIRRRERELMTKDATIREIHHRVKNNLQTVAALLRLQSRRLAAEDPDGRARAALDEAVRRVGSIAIVHETLSQNLDETVEFDEIADRVVAMVAEINPGRVTGRRTGRFGVLKAEVATPLSMVLTEVLQNALEHGFGPGESGRVEVTALRSSGRQDSRLLVTVQDDGRGLPEGFDPATSGSLGLQIVRTLVEGELAGTFSMARAPEGGTRVVFDIPVQPEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBL1</accession>
    <name>A0A0F7NBL1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Toxin-antitoxin system toxin subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_20055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017387.1">
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_20055"/>
    <dbReference type="EnsemblBacteria" id="AKH84097">
        <property type="protein sequence ID" value="AKH84097"/>
        <property type="gene ID" value="AA958_20055"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_20055"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4225"/>
    <dbReference type="OrthoDB" id="1996962at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="5"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="68" mass="7056" checksum="2359EE85942CE20C" modified="2015-07-22" version="1">MSTIHWVKSSYSNGDGGGCVEWAPVVAASGVVPVRDSKDPDGPALAFSAAGWRAFVAGVRAGEFAERF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBT0</accession>
    <name>A0A0F7NBT0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AMP-dependent synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_29190</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018870.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_29190"/>
    <dbReference type="EnsemblBacteria" id="AKH85641">
        <property type="protein sequence ID" value="AKH85641"/>
        <property type="gene ID" value="AA958_29190"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_29190"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6154"/>
    <dbReference type="OrthoDB" id="377638at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008756">
        <property type="term" value="F:o-succinylbenzoate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010192">
        <property type="entry name" value="MenE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01923">
        <property type="entry name" value="menE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="3">
        <location>
            <begin position="12"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="4">
        <location>
            <begin position="437"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH85641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="525" mass="55610" checksum="601A0C21CE7073F5" modified="2015-07-22" version="1">MRNEGLGSWPARRARKTPHRTALLHHTTLRNRTGPRHHDDAAGHADAAVSYAGLHERTTRLAHALRAHGVRRGDRVAYLGPNHPSFLEALFAAGLLGAVFVPLNTRLAAPEIAYQLADSGARLLLHAPSHTALATDATGAGGDDAQGTPARVAVGGSAYEELLAAMVTEPVDEPVALDDTAIIMYTSGTTGRPKGAVLTHGNLTWNAVNVLIDHDLTAGEVALASAPLFHIAGLNMLALPVLLKGGTCLVVEGFDPGDTLELIERHRVTFMFGVPAMFDRIAHHRRWAGADLSSLRILTCGGSPVPTRLIATYQSRGLTFLQGYGMTEAAPGVLFLDAEHATAKAGSAGVPHFFSDVRVVRPDLTPVDVGEAGEILVRGPHVMPGYWGLPEESAAAFADGWFRSGDAARVDTDGYVTVVDRIKDMIISGGENIYPAEVEDALLAHPDIVECAVIGVPDEKWGEVGRAVVVAREGAELDPDEVLGSLSGRLAKYKIPKSAVTAAELPRTASGKLLKARVRSLYGTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBT5</accession>
    <name>A0A0F7NBT5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Leucine/isoleucine/valine transporter ATP-binding subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">livG</name>
        <name evidence="5" type="ORF">AA958_29225</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018875.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_29225"/>
    <dbReference type="EnsemblBacteria" id="AKH85646">
        <property type="protein sequence ID" value="AKH85646"/>
        <property type="gene ID" value="AA958_29225"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_29225"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6161"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032823">
        <property type="entry name" value="BCA_ABC_TP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12399">
        <property type="entry name" value="BCA_ABC_TP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="7"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="39"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH85646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="262" mass="28026" checksum="801AC864011AE2CD" modified="2015-07-22" version="1">MTAAAMLRVEDLGRAFGGVYAVQDVNLSVAEGETRAVIGPNGAGKSTLFNLVSGHLTADHGTVHYSAGGSLRRIDRLSAHARARQGIAIVFQGARLFHGMTALENVMVGAHARTRHGFVSAALRLPRHHREEAAIRADAEAALDRVGLADWADRSADVLPLGQQRALQVARALCARPRLLLLDEPASGLRAAEREALARLIESLRTEGLTMMLIEHDVAFVARLADRVTVLDLGREIAEGTPGEIRDDDAVLAAYLGQETAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBU8</accession>
    <name>A0A0F7NBU8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TerD-family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_31285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019183.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_31285"/>
    <dbReference type="EnsemblBacteria" id="AKH85955">
        <property type="protein sequence ID" value="AKH85955"/>
        <property type="gene ID" value="AA958_31285"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_31285"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6610"/>
    <dbReference type="OrthoDB" id="1437544at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd06974">
        <property type="entry name" value="TerD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003325">
        <property type="entry name" value="TerD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02342">
        <property type="entry name" value="TerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TerD" evidence="1">
        <location>
            <begin position="5"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="177" mass="18612" checksum="2665FF28852FBA1D" modified="2015-07-22" version="1">MTGLNRGVGKVEIALKWDPSPLGAPPHDLDLIAATYRADDPRGEPAYLVHFDSRSPDGTITLQRQSQTGQGFGADEVMTLEFARIAPAYGRVVVGVAIQQGAGRRTFGEVASTGVQIREGYAELAADDFAGVADATAATVAEFVREPAGTWRFRPVVQGFDTDPASFSALMGTVAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBX7</accession>
    <name>A0A0F7NBX7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NADH:ubiquinone oxidoreductase subunit M</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_20640</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 3">Membrane</location>
            <topology evidence="1 3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I subunit 4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017483.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_20640"/>
    <dbReference type="EnsemblBacteria" id="AKH84197">
        <property type="protein sequence ID" value="AKH84197"/>
        <property type="gene ID" value="AA958_20640"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_20640"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4354"/>
    <dbReference type="OrthoDB" id="535707at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010227">
        <property type="entry name" value="NADH_Q_OxRdtase_chainM/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003918">
        <property type="entry name" value="NADH_UbQ_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43507">
        <property type="entry name" value="PTHR43507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01437">
        <property type="entry name" value="NUOXDRDTASE4"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01972">
        <property type="entry name" value="NDH_I_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="285"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="315"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="375"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="413"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="448"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="490"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="6">
        <location>
            <begin position="151"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="524"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH84197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="545" mass="58034" checksum="2B4CD6DE04C1D385" modified="2015-07-22" version="1">MADSSTFPLLTITAAVPAVGAIATAAVPAAKRELAKWLALGVSLATLVLAAVIAVRYDPDGDRFQLTESRAWIADFGVRYELGVDGIAVVLVALTALLIPFVILAGWHDADPVTASDSGSAAGKSSRWRPTQGFFALILAVEAMVIVSFLATDVFLFYIFFEAMLIPMYFLIGGFGDKAHEHGEEEAARQRSYAAVKFLLYNLAGGLIMLAAVIGLFVVTNDQLGAGTFSLQEILQARANGDLDISTNTERLLFLGFFFAFAVKAPLWPLHTWLPNAMGESTPPVAVLITAVVDKVGTFAMLRFCLGLFPEASDWATPVVLVLALVSILYGALLAIGQRDIKRLIAYASISHFGFIVLGIFVMTSQGQAGATLYMVNHGISTAVLMLVAGFLITRRGSRLIGDYGGVQKVAPVLAGTFLIGGMATLSLPGLAPFVSEFLVLVGTFSRYPAIGIIATVGIVLAAIYVLVLYQRTMTGPVTEKVAKLPDLRVREVLVVAPLIALLIGLGVYPKPLTEIVNPAVEHTMSDVQKSDPEPDVNPVEAAHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NC34</accession>
    <name>A0A0F7NC34_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">N-acetylmuramoyl-L-alanine amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_25445</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018255.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_25445"/>
    <dbReference type="EnsemblBacteria" id="AKH85004">
        <property type="protein sequence ID" value="AKH85004"/>
        <property type="gene ID" value="AA958_25445"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_25445"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5363"/>
    <dbReference type="OrthoDB" id="1584918at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06583">
        <property type="entry name" value="PGRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036505">
        <property type="entry name" value="Amidase/PGRP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002502">
        <property type="entry name" value="Amidase_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01510">
        <property type="entry name" value="Amidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00644">
        <property type="entry name" value="Ami_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55846">
        <property type="entry name" value="SSF55846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetylmuramoyl-L-alanine amidase" evidence="3">
        <location>
            <begin position="92"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH85004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="253" mass="27429" checksum="B3E75687DA984D3B" modified="2015-07-22" version="1">MPTTDGAEPARGAGEPGADPGPPASAEPRTRSSRRAVLAALGVGAVGAGLGWAGYEQLKRMWWQIPGIDKPRRPGELDYAAAGWAGASEANWRRADRPADYGIDRVVIHVTEGSYAVALQVFGDPGHGAATHYVIRAGDGHVAQTVRELDVAFHAGNREWNERSVGIEHEGFVDRPETLTDVMYRSSAELTADICRRYGIPVDREHIVGHNEVPGADHTDPGPHWDWPRYMGLVRRAHAAAERRASARPARDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NC48</accession>
    <name>A0A0F7NC48_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_30085</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018994.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH85766">
        <property type="protein sequence ID" value="AKH85766"/>
        <property type="gene ID" value="AA958_30085"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_30085"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6352"/>
    <dbReference type="OrthoDB" id="2130098at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH85766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="420" mass="46575" checksum="601BB8E8E305E3E8" modified="2015-07-22" version="1">MTAGPELERLAGELERLQEELSGLVTGEAPAPASAYEALRQDGELHPWTSTAVRLWEEQLADGADSEVVHHLAIAHHARAYDLEAAGDDAAFGHFEEALRHWASLHGDRDFWRRAYERLTGAMGVPVPGEVVEEARARLPRNLLEPHLTLAARFRITDPRRARRHVRLVTDSGFPAAIVAEARADLVRDVLDGVPQAVAEGRFGETLDTLETWLHLDPEGHGLLRAVLFTGRSWMERLRDEPYATRRMDELLDRVDRLVRPGLALAGPPSGELAKELARHEFLLALRSFGAFGTAPPSPDSLGSRAEVEEARRAAGRASRQVETALELYPEMGDDPRYAEVTELRSTVLPRYRAWLSALSAQFLLTAFGIGDRELARARQLLDEAGEYTAADPSLESFVRSLENLLSIRGPGRPGEMRHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NC96</accession>
    <name>A0A0F7NC96_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dihydrofolate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_25545</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018274.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_25545"/>
    <dbReference type="EnsemblBacteria" id="AKH85023">
        <property type="protein sequence ID" value="AKH85023"/>
        <property type="gene ID" value="AA958_25545"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_25545"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5385"/>
    <dbReference type="OrthoDB" id="1435073at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2-Hacid_dh_C" evidence="2">
        <location>
            <begin position="99"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH85023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="305" mass="32678" checksum="21A99E6664E6B61A" modified="2015-07-22" version="1">MWLPIPPDQITGLPPELDYVHWDAEPEFPADPADCVFLVAPYMRRITHDPVPRMTALKVLQTLTAGVDDFLPRLSTLPPGTRLCNARGVHEASTAELALALTLASLRGIPDFVRNQDAEEWRGGFHPSLADKTVLILGYGAIGGAVEDRLAGFECERVIRIARSPRTTPRGPVHALDGVGELLPAADVVIVTTPLTDATRGLVDAGFLARMKDGALLVNVARGAVVDTKALLDEVTPGRLRAALDVTDPEPLPPGHPLWHAAGALISPHTGGPTSAFRPRAERLLRAQLRRFAAGEPVEHVVAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCW9</accession>
    <name>A0A0F7NCW9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_31860</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019279.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_31860"/>
    <dbReference type="EnsemblBacteria" id="AKH86051">
        <property type="protein sequence ID" value="AKH86051"/>
        <property type="gene ID" value="AA958_31860"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_31860"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6728"/>
    <dbReference type="OrthoDB" id="1024978at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="2">
        <location>
            <begin position="109"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH86051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="463" mass="49219" checksum="427921E0A33D330C" modified="2015-07-22" version="1">MAAPGPEALVAGAVPNVPVPGAAPSTPAPAARPLRKAELHGSVSDPLLDTMNFLNEITLRYPDAISFAPGRPYDGFFDTEQVFTHMRTYLDHLAARGGTPEDIRTALYQYGPTAGQIREIIAESLRADEGIDVPAESVVVTVGAQEAMLLVLRALISGPDDVLMVASPCYVGITGAARLLDVAVHPVEEREDGFHAADLEAAVLAEKARGRRPRAFYLVPDHSNPSGATLTPRARTDLLDLAARHDLLILEDSPYRLVSPGPPPPTLKSLDRTQCVVHLGSYSKTVFPGARVGFAVADQTVADDSGATSLLADELARIKSMVTVNTPSLSQAAVAGALLAAQGLVSELNSRAAAYYGDAMRTMLRALDERLPAARRNALGVRWNRPEGGFFLTVQVPFPADDAALTRSAQDFGVIWTPMSHFHPGAGGGHRALRLSTSYLTTEEIDEGAARLARFIEAGTRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-12-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7ND10</accession>
    <name>A0A0F7ND10_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AA958_32185</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019339.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86111">
        <property type="protein sequence ID" value="AKH86111"/>
        <property type="gene ID" value="AA958_32185"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_32185"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6796"/>
    <dbReference type="OrthoDB" id="149255at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004869">
        <property type="entry name" value="MMPL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03176">
        <property type="entry name" value="MMPL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="187"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="227"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="279"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="306"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="365"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="530"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="556"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="597"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="644"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="666"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="8">
        <location>
            <begin position="204"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="719"/>
            <end position="738"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH86111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="738" mass="75588" checksum="255CDCFE002998F8" modified="2015-07-22" version="1">MLTPIAELVLRRTRLVLALAVVAVVAMAALGFGAFGKLSAGGFSDPGSPSSKAQEVIDDRFGGDTNLVLLVSAESGGLGGDAARERGLEVTEGLRAESTVTSVMSYWDRGGEGLTSQDGSQALVLAHVAGGDEKEADHARTLTDAYAGTRDGVTVRAGGGAAVSNDVSTQVAADLALAEAIAVPLTLVLLVLAFGSVIAALLPLAIGLVAIFGTFAELWVLGSLTDVSVFSVNLTIALGLGLGIDYGLLLVSRFREQLAAGDEVPAAVRRTVATAGRTIAFSSATIVAALAALLVFPQYFLRSFAYAGIGVVAISAISALVIIPALLAVLGHRVNRGRIPGARAMRRPDAPLWGRIAGAVMRRPALTALPVLGVLLLAASPLLGVSYGTPDERVLPESAQSRQVATELREDFAVDDSTAIDVVTTGAVAGPDLTAYATELSRLDGVARVTASNGTYAGGAAGPAGPAAEALGRPDAQRLTVSVEPAPKSGAAQRLVEDVRAVPAPGGVETLVGGTDAELVDAKDSIGSRLPLAVGMVLITTFVLLFLFTGSVVQPLRAVVLNAVSLGAAMGVMVWIFQDGHLSGLLGFTPQPMDTAMTVLMFCIAFGLSMDYEVFLTSRIKELHDAGADPATSVTSGLARTGRIVTMAAGLLAVSFFAFGTGQVSFIQMFGLGSGLAILIDAIAVRGVLVPAAMRLLGRHAWYAPRWLRRVHGRVGLSEAGPGPAAPEGESERAPAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7ND39</accession>
    <name>A0A0F7ND39_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_32375</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019368.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86141">
        <property type="protein sequence ID" value="AKH86141"/>
        <property type="gene ID" value="AA958_32375"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_32375"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6834"/>
    <dbReference type="OrthoDB" id="1474443at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039446">
        <property type="entry name" value="DauR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039445">
        <property type="entry name" value="DauR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013559">
        <property type="entry name" value="YheO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35568">
        <property type="entry name" value="PTHR35568"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13309">
        <property type="entry name" value="HTH_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08348">
        <property type="entry name" value="PAS_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS_6" evidence="1">
        <location>
            <begin position="9"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_22" evidence="2">
        <location>
            <begin position="147"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH86141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="207" mass="22585" checksum="59347850F558B47B" modified="2015-07-22" version="1">MSTEDELLLREAEKIVTALGRMFPGVCEVVLHDLRDPRHAVRTIENPLSGRGPGDPATELGLARIEDPDYPEVIQNYPNRFPDGRPAKSTSIGIRNSSGAYVAALCLNLDVSVLDRTARTLQALTAVEDPGLPLTETLRARTADELSAAVEEFAAARGQTPRALGSADRRELVRDLRDRGLLEVRSAVRLVTGLLGVSRATVYNYLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDA2</accession>
    <name>A0A0F7NDA2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_27740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018633.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_27740"/>
    <dbReference type="EnsemblBacteria" id="AKH85399">
        <property type="protein sequence ID" value="AKH85399"/>
        <property type="gene ID" value="AA958_27740"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_27740"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5846"/>
    <dbReference type="OrthoDB" id="116233at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="651"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="654"/>
            <end position="674"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="674" mass="73484" checksum="DE106FA5234B163A" modified="2015-07-22" version="1">MLRELVPRMVGLHHTKRKAVRQEPRDEVPAVLLHGGHGSGRTAVLDALREAYADRVPVAAVDCAGVRDDDAAVSNTSPVAELLTGLARGLSAHCPGFGRLRLPRLLTGLVAVSAWHRGELDEQACARERVEALLTDCGLEKNPERARNWPGDVLDRIGGWGTDELGPVAAASVRLFTDRYLGFRESRAVRQWYGGLADVPTSQQDDNHVLTALCRAFHLGEGMRRRIEVHLVEALLEDLRAAYTGWRHLNAAPRPLALLDNVHTAAGTELLDLLLARRVTAAERPDPLVVVAATLGEPHGDRYAGAARWTAANVPGLREWRRGGEPGDPAAGLVTLPLPPLDPDELLSMMHVGEERAVRQEVARAVHRFTGGSPLGCRIFYDALDAAPDPAAVEPHELTRLRLAGEHVTELILAALVPDAGLSSYLVLLSVAQDAAAARALAGAYLTRDHQAGAVEEARSHLRDERWPQPGRPFVGDDFLRAVLVDELRRRPADATDPPQPWPELHELLRRHHEDRGEHAAAHHHELAAGRPAEPARWLAETLHGPATDRWLTDLWHIARAPHPPDPAWADVCRATASGERDGTLAGADSVARSVNRLLHAVWYAADPLSVPDAHLRGRIGRELDFLSFEHPTGGRALYAASQDWPAALKELRTPDSAVERREGGEEGRGHAIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDE6</accession>
    <name>A0A0F7NDE6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Arginine deiminase</fullName>
            <shortName evidence="3">ADI</shortName>
            <ecNumber evidence="3">3.5.3.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Arginine dihydrolase</fullName>
            <shortName evidence="3">AD</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">arcA</name>
        <name evidence="5" type="ORF">AA958_27680</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>H2O + L-arginine = L-citrulline + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:19597"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
            <dbReference type="EC" id="3.5.3.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid degradation; L-arginine degradation via ADI pathway; carbamoyl phosphate from L-arginine: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the arginine deiminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.3.6" evidence="3"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018622.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_27680"/>
    <dbReference type="EnsemblBacteria" id="AKH85388">
        <property type="protein sequence ID" value="AKH85388"/>
        <property type="gene ID" value="AA958_27680"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_27680"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5832"/>
    <dbReference type="OrthoDB" id="592329at2"/>
    <dbReference type="UniPathway" id="UPA00254">
        <property type="reaction ID" value="UER00364"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016990">
        <property type="term" value="F:arginine deiminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019547">
        <property type="term" value="P:arginine catabolic process to ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018101">
        <property type="term" value="P:protein citrullination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00242">
        <property type="entry name" value="Arg_deiminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003876">
        <property type="entry name" value="Arg_deiminase"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006356">
        <property type="entry name" value="Arg_deiminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01466">
        <property type="entry name" value="ARGDEIMINASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0056">Arginine metabolism</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Amidino-cysteine intermediate" evidence="3 4">
        <location>
            <position position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR006356-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH85388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="413" mass="45734" checksum="BBF8E8583799A3CE" modified="2015-07-22" version="1">MPAPSFRVDSEAGRLRRVILHRPDMELKRLTPRNKDALLFDDVLWVRRAREEHDGFADVLRDRGVQVHLFGDLLAESLDLPEARALVLDRVFDEKEYGPLATEKLRSTFDSMDSAALVEALVGGMTKREYLDGFAEPASVRFHVMDPDDFLLGPLPNHLFTRDTSCWVYDGVSINAMRWPARQRETVHFEAIYKHHPLFAGPESGEFHVWSGGQEDYPSTIEGGDVLVIGNGAVLIGMSERTTPQAVELLARGLFAAGSARTIVALDMPKARAFMHLDTVMTMIDGDTFTQYAGLGMLRSYTIEPGSGSDDLKVTDHPPEHMHNAVAAALGLDGIRVLTATQDVHAAEREQWDDGCNVLAVEPGVVVAYERNSTTNTFLRKQGIEVIEIRGSELGRGRGGPRCMSCPVERDPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDM8</accession>
    <name>A0A0F7NDM8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_08285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019863.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_08285"/>
    <dbReference type="EnsemblBacteria" id="AKH86610">
        <property type="protein sequence ID" value="AKH86610"/>
        <property type="gene ID" value="AA958_08285"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_08285"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1748"/>
    <dbReference type="OrthoDB" id="1515497at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="50"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="241" mass="26683" checksum="5DA1B688918367DB" modified="2015-07-22" version="1">MRDPSIRRSVALFRAFMKEQDDPARAYGLLARDAADQVERITPLKGQLVVDVGGGGGWFTEEFRSRGAEAYLFDCDAGEMAAGSDVTTGAVVADGYLLPLADGVADVAFSSNVLEHVADPETFLSELIRVTKPGGLLYVAFTNWLSPWGGHEQAPWHYLGADRARRRYTRRTGRDPKHTLGENLFAIHIGPTLKAVRARDDVEVVAARSRYWPFLAEAVVRVPGVREFATWNLLLILRRCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDR2</accession>
    <name>A0A0F7NDR2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH tetR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_33645</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019578.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86356">
        <property type="protein sequence ID" value="AKH86356"/>
        <property type="gene ID" value="AA958_33645"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_33645"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.7104"/>
    <dbReference type="OrthoDB" id="1437290at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011075">
        <property type="entry name" value="TetR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16859">
        <property type="entry name" value="TetR_C_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="17"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH86356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="208" mass="21667" checksum="48DF2A30804BCD6D" modified="2015-07-22" version="1">MGETGGPRAPRGRPRSERARAAVLAAATELLVAGGVQAVTMEAIAARARVSKSTVYKWWPTRGHVMLDSLAHVTGDPPAGPAAGASLADALAAEAGALVRVFRDTAAGPLVADLAAAAQADPGIRTALDERWVRPRRAACARLLHDAVARGELRPDTDVAAALDQLFAPVYHRLLFGHAPLAENLAATLVRQLLDGLGGGRGRSDEDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDZ5</accession>
    <name>A0A0F7NDZ5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Release factor glutamine methyltransferase</fullName>
            <shortName evidence="6">RF MTase</shortName>
            <ecNumber evidence="6">2.1.1.297</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">N5-glutamine methyltransferase PrmC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Protein-(glutamine-N5) MTase PrmC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Protein-glutamine N-methyltransferase PrmC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">prmC</name>
        <name evidence="9" type="ORF">AA958_24820</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 6">Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-methionine = H(+) + N(5)-methyl-L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42896"/>
            <dbReference type="Rhea" id="RHEA-COMP:10271"/>
            <dbReference type="Rhea" id="RHEA-COMP:10272"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30011"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61891"/>
            <dbReference type="EC" id="2.1.1.297"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.297" evidence="6"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018144.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_24820"/>
    <dbReference type="EnsemblBacteria" id="AKH84892">
        <property type="protein sequence ID" value="AKH84892"/>
        <property type="gene ID" value="AA958_24820"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_24820"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5233"/>
    <dbReference type="OrthoDB" id="1816476at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102559">
        <property type="term" value="F:protein-(glutamine-N5) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036009">
        <property type="term" value="F:protein-glutamine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018364">
        <property type="term" value="P:peptidyl-glutamine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02126">
        <property type="entry name" value="RF_methyltr_PrmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004556">
        <property type="entry name" value="HemK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040758">
        <property type="entry name" value="PrmC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019874">
        <property type="entry name" value="Release_fac_Glu-N5_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007848">
        <property type="entry name" value="Small_mtfrase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05175">
        <property type="entry name" value="MTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17827">
        <property type="entry name" value="PrmC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00536">
        <property type="entry name" value="hemK_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03534">
        <property type="entry name" value="RF_mod_PrmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PrmC_N" evidence="8">
        <location>
            <begin position="9"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="MTS" evidence="7">
        <location>
            <begin position="114"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="188"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH84892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="285" mass="31250" checksum="28BA1A76E076C818" modified="2015-07-22" version="1">MNLLLVEVAQATRRLADAGVPSPRFDAEELAAYVHGVPRGELHRVADADFDARYWEAVARREAREPLQHITGVAYFRYLELQVGPGVFVPRPETESVVDWAIAAVRAMDVVEPLIVDLCTGSGAIALAMAQEVPRAAVHAVELEETALNWARKNAAHNDGGARVVLHHGDARTALPELNGQVDLVISNPPYIPLTEWEHVAPEARDHDPQAALFSGEDGLDLIRGLEVAARRLLRPGGVLVVEHADTQGGQVPWLFTEERGWADAADHPDLNNRPRFATARRVRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NE05</accession>
    <name>A0A0F7NE05_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ATP synthase subunit beta</fullName>
            <ecNumber evidence="11">7.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">ATP synthase F1 sector subunit beta</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">F-ATPase subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">atpD</name>
        <name evidence="13" type="ORF">AA958_24875</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + 4 H(+)(in) + H2O = ADP + 5 H(+)(out) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell membrane</location>
            <topology evidence="11">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="11"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018153.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_24875"/>
    <dbReference type="EnsemblBacteria" id="AKH84902">
        <property type="protein sequence ID" value="AKH84902"/>
        <property type="gene ID" value="AA958_24875"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_24875"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5244"/>
    <dbReference type="OrthoDB" id="430176at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1140.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01347">
        <property type="entry name" value="ATP_synth_beta_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005722">
        <property type="entry name" value="ATP_synth_F1_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024034">
        <property type="entry name" value="ATPase_F1/V1_b/a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="SSF50615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01039">
        <property type="entry name" value="atpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="5 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 11" id="KW-0139">CF(1)</keyword>
    <keyword evidence="11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 11" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AAA" evidence="12">
        <location>
            <begin position="161"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="169"/>
            <end position="176"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AKH84902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="483" mass="52437" checksum="40CB012C9AA1D027" modified="2015-07-22" version="1">MTTATTTEAKATATGRVARVIGPVVDVEFPVDAMPEIYNALTVEVADPAQAGEIKVLTLEVAQHLGEGLVRAISMQPTDGLVRQAPVTDTGEGLTVPVGDVTKGRVFNTLGEILNDEVDESEIQERWAIHRTAPPFDQLEAKTEMFETGLKVVDLLTPYVKGGKIGLFGGAGVGKTVLIQEMIMRVAKLHEGVSVFAGVGERTREGNDLIAEMAESGVLPQTALVFGQMDEPPGTRLRVALAGLTMAEYFRDVQKQDVLFFIDNIFRFTQAGSEVSTLLGRMPSAVGYQPNLADEMGLLQERITSTRGHSITSMQAIYVPADDYTDPAPATTFAHLDATTELSRPISEKGIYPAVDPLASTSRVLDPRYIAQDHYECATRVKAILQKYKDLQDIIAILGMDELSEEDKLTVSRARRIERFLSQNTHAAKQFTGLDGSDVPLDESIAAFNAIADGEYDHFPEQAFFMCGGLEDLKAKAKELGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NEK2</accession>
    <name>A0A0F7NEK2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_18930</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_18930"/>
    <dbReference type="EnsemblBacteria" id="AKH86885">
        <property type="protein sequence ID" value="AKH86885"/>
        <property type="gene ID" value="AA958_18930"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_18930"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3974"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="215"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="250"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="280"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="303"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="337"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="363"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="392"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH86885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="411" mass="41485" checksum="3811896EB4CA318B" modified="2015-07-22" version="1">MTYGTVLGSPYVARLLGATLVGRLPNGMAPVAILWWAVAAHGGLAFAGLLSAVYGLAASLAQPVKGRLMDRHGQPAVHLPAALANSTLLAALPLTGSYGGPAAATAVVVVAGLTTPALETGLRALWPSVLPDPGLRHAALALDTGSQGLLYIVGPPLAAALTAVHSAALALAATAALGLLGAVVVASAPPTRRWRPATTAGPAAETARRLANPGLVLLFVALTGIGFAIGAMNVWAIAMAERHQQGMLSGTLPAAFSAGSFLSGLIYGRRTWPGTTTGRLIAATGGFLAGWLPLFALPGPYAATAAIVLPGAFLTVVIACAFVTTDTLTPTGRTSEAYAWLLLSIGTGTSAGTALAGRLAEQPIAGAALPAAGAAFALTVLLAARRRLATACDRPRRGRHRRPARGRHRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NEQ5</accession>
    <name>A0A0F7NEQ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amino acid ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_31130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019157.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_31130"/>
    <dbReference type="EnsemblBacteria" id="AKH85929">
        <property type="protein sequence ID" value="AKH85929"/>
        <property type="gene ID" value="AA958_31130"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_31130"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6578"/>
    <dbReference type="OrthoDB" id="538961at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028081">
        <property type="entry name" value="Leu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13458">
        <property type="entry name" value="Peripla_BP_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519371" evidence="1">
        <location>
            <begin position="36"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_6" evidence="2">
        <location>
            <begin position="43"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH85929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="403" mass="42597" checksum="9E167C2BE96CE762" modified="2015-07-22" version="1">MFVNASIRRPGRSRTRAVAATAAAVSLALAGCSGGDSGSGDETVKVGLLAALSGTYEAVGTDLRNGFQLYLDTHNGKLGGREVELSVGDEGDGPPTAVPAATKLVKKDRVDVMTGIVANGSYQAVLPMLEQNKIPLVSSNGRPELKDVSRVWHTSFLSKDYGTAIAQYVKDEVDGPVYAIGPDYQGGYDQLGGFTETFDEIGGELANSDGETTWTPFPDTTNFTPYFADIAQSDAKAVYTFYAGKAAIDFVKQYAQSDVADLPLYASGSLTEGSVLQAQGEAADGIQSVSNYVADLDNDANRKFVSDWTAKHDTPPTGYAMASYDAAAVLDMAIAAAAEKGEVNSDTINTALGSLGQIESPRGIWAFGKKSHAPVQKWYLREVRKDGKQLSNVTVQDLATLGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NEX7</accession>
    <name>A0A0F7NEX7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_23910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020366.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_23910"/>
    <dbReference type="EnsemblBacteria" id="AKH87000">
        <property type="protein sequence ID" value="AKH87000"/>
        <property type="gene ID" value="AA958_23910"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_23910"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5039"/>
    <dbReference type="OrthoDB" id="159474at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH87000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="1072" mass="115308" checksum="A856DDC7697EDBC0" modified="2015-07-22" version="1">MPPDARGLADVLWFAEELARSAEAVGGAEARADAPGPANRMESATFPEAADAADDSGSAPAGGDGDGTDGTGAGARAAPERRVGLAAGPGLLPRTPMPDAVDTPAYRQVGRVGVPEPAALPALVPLQRALRPLRRYQPRVAAVAPGELDEEETAELSARADLVIPVLRTPRRRATLQLLMDASPAMEVWSRLLEDLRTVAERSGAFRDVTVHRLHPLPDGGVGCTGEAGRPSMLQDAGQLHDPGGRRLTLVLSDCAGPMWHDGRMQRMLHGWLGTAPVAVVQPLPHRRWREMPFAALPGLLVRHPGPYPTLEFRPGTRGDVPPAGARALPVLAPEPAAVGTWARLLAAGEGLSLPGAAGWVRRDHTAAPAAVARPADVRPDPAATLAAFDATASPAARLLAIHLAAVPLVLPVIRLVQRALFPDTGPAETAEILLSELVVARDPARGAGREPAREPVGDDPWFDFRPGVRELLLRRLSHGEAALVLKHCSLYIERTFGQGARNFPAVAVAYLSGEDREPDLGGAKVPDQFARVSEQVLRAFQPAYRGPAAAGGAELLRQYEETRSVRDLLDAVRALRRAVVEERDTAQQGLLARALLLHWQRLREPDALAEAEQWARSALAADGPGAPAGGGVPAAGAPPLRERLTYAEVMWEVARERVADGEHEQAVAALRASAAQLRDSRALATTHAARRERGGLLAEVLRRLHSLTGDGAALHEAEETIDELLAGWPDEELVPARLFLARGRVTLGRAQAEHTVDETRAYGLRAAADLRTGVDLLRMEGGPELRRQECEALLDLAEANTTAAGDAGAARALAALDRAGRLAAALDDYRLQAESLRRKARVRIAEFTRGGGAELLVEADGWLTDALALLPPGAALYGEVLTEHGELLLRRGRLAPEDAGLRGRAVPVLREVLAETPQRHPDLPRRQLLFGRALRLRYEASGTRTDLYEAEWVLDRAAREDDAPARVRAQAWLELGDVQLLIDIRTEFRQRQERAADCYRRAAMLAEEAGDAEEAARAHHRRGQMLEPTAGRAVALRAYRDAWEQWSRAEQTESEGALVTREQIRALEAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NF19</accession>
    <name>A0A0F7NF19_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent zinc metalloprotease FtsH</fullName>
            <ecNumber evidence="5">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ftsH</name>
        <name evidence="9" type="ORF">AA958_18090</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">In the C-terminal section; belongs to the peptidase M41 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the central section; belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="5"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020185.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_18090"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
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</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
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        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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    </dbReference>
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            <begin position="16"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH85968.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="80" mass="8226" checksum="0087CB4C097DD4A2" modified="2015-07-22" version="1">MQVVNGVPAGRLGNVEWRKSHHSNPNGECVELAGLSGGEVAVRNSRDPQGPALVYGPAGLAAFLRAAKEGDFDDLVTAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NF61</accession>
    <name>A0A0F7NF61_9ACTN</name>
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        <recommendedName>
            <fullName evidence="8">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AA958_32175</name>
    </gene>
    <organism evidence="10 11">
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        <lineage>
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            <taxon>Actinobacteria</taxon>
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    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <topology evidence="8">Multi-pass membrane protein</topology>
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        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ABC-2 integral membrane protein family.</text>
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AKH86109">
        <property type="protein sequence ID" value="AKH86109"/>
        <property type="gene ID" value="AA958_32175"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_32175"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6794"/>
    <dbReference type="OrthoDB" id="1543624at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="98"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="153"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="176"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="9">
        <location>
            <begin position="52"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AKH86109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="303" mass="33731" checksum="8E52CFC5A212E9A5" modified="2015-07-22" version="1">MGAPPKRHPDDGLTPAELAAKYGLTVSGARPGLPEYVRQLWARRHFILTFSRAKLTAQYSKAKLGQVWQVLTPLLNATVFFFIFGVLLGGRAGMSNDVYIPFLVTGVFVWTFTQQSVMSGVRSISGNLGLVRALHFPRAALPISFSLQQLQQLLYSMTVLAVILVAFGWYPTWTWLLIVPILALQYVFNTGLAMVVARLGSDTPDLAQLMPFILRAWMYGSGVMFPLQYMMTVRADAPQWAADLVAMNPAAVYMDLMRYALMGDFPKAYLPPNVWLLAAGWAVVVGAFGFVFFWKAEERYGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFA3</accession>
    <name>A0A0F7NFA3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RNA polymerase sigma 70</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AA958_30795</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Interacts transiently with the RNA polymerase catalytic core formed by RpoA, RpoB, RpoC and RpoZ (2 alpha, 1 beta, 1 beta' and 1 omega subunit) to form the RNA polymerase holoenzyme that can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH87155">
        <property type="protein sequence ID" value="AKH87155"/>
        <property type="gene ID" value="AA958_30795"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_30795"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6509"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="7">
        <location>
            <begin position="2"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="8">
        <location>
            <begin position="94"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH87155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="293" mass="31605" checksum="60D251AA0F7F4423" modified="2015-07-22" version="1">MRAVAYRMLGSVPEADDAVQEAWIRLSRSDTSEVENLSGWVTTIVARVSLNMLQSRRSRPEVLVDTTDAGDPQDELSPEDPEEEAVIADSVGLALLVVLDTLTPAERLAFVLHDMFAVPFEEIATIVDRSPAAARQLASRARRRVQRSTPTARRGESFGVYDAAASLPSGKADLATAFLAASREGNFEALLAMLAPDIVLRTDAAAMRMSLEAGLRGMHPITDVPEIRGADAVTRVFAGRTWNPAPALIDGAAGLVWLVRGRPHVAFCFATENDRITAIDIKADLDGLGIVFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFJ0</accession>
    <name>A0A0F7NFJ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Iron ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_26035</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020418.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_26035"/>
    <dbReference type="EnsemblBacteria" id="AKH87041">
        <property type="protein sequence ID" value="AKH87041"/>
        <property type="gene ID" value="AA958_26035"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_26035"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5482"/>
    <dbReference type="OrthoDB" id="1783638at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="181"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="334"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="368"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="401"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="456"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="502"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="48"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="330"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH87041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="534" mass="56204" checksum="915AA6A860B1ED61" modified="2015-07-22" version="1">MAVPAAFLGVFFAYPVSAIVARGLREGGRWQFGRIPDVLGDPDILGVLWFTLWQAAASTGLTLVLALPAAYVFARFDFPGKQLLRALVTVPFVMPTVVVGSAFLALTGRGGVLDGWWGIRLDTTVWAILLAHVFFNFAVVVRTVGGLWAQLDPRQEEAARVLGAGRLAAWRHVTLPALGPAVAAAALMVFLFTFTSFGVIQILGGPAYATLEVEIYRQTADFLDLPTAAVLSLLQLAAVAAVLAVHAWTVRRRETALRLVAPETTARRPRGAGERALLGGVVAVVAVLLLAPLAVLVERSFATPGGHGLGFYRALQESDGTFAVPPLEAVGNSLAYAAVATVIAVVVGGLAAAAVTRRAGPLVRGFDALLMLPLGTSAVTVGFGFLIALDSPPLDLRSSWILVPIAQALVGVPFVVRIMLPVLRAVDDRLREAAAVLGASPLRAWREVDLPLVRRAVLVAAGFAFAVSLGEFGATVFIAGPDRPTLPVAVARLLGRAGETNYGQAMALSTILMAVCAASLLLLERVRKNQAGEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-10-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFS7</accession>
    <name>A0A0F7NFS7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_32580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86173">
        <property type="protein sequence ID" value="AKH86173"/>
        <property type="gene ID" value="AA958_32580"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_32580"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6879"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH86173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="66" mass="7532" checksum="CCD0594862A717FF" modified="2015-07-22" version="1">MGKEPLSEDQQDAIVMELAVNVETLSEEEFEHLYRQLGSDHQSQVNDNVREFAANAIGDEHWDSDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NGG7</accession>
    <name>A0A0F7NGG7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">6-phosphofructokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_03770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019757.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_03770"/>
    <dbReference type="EnsemblBacteria" id="AKH86529">
        <property type="protein sequence ID" value="AKH86529"/>
        <property type="gene ID" value="AA958_03770"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_03770"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.793"/>
    <dbReference type="OrthoDB" id="1832160at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HATPase_c" evidence="1">
        <location>
            <begin position="8"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="124" mass="13443" checksum="4B5D92C52E09BC9B" modified="2015-07-22" version="1">MFARSAASVGKARDFAATVVGTDERTDDIRVCVSELATNALQHTPVGRRFLVRITVNECVVRIEVHDAGGGTPHLCTPADTDDRGRGLMLVSDFADDWGVSDRFGPGKLVWADFKIQTTGETLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NGZ6</accession>
    <name>A0A0F7NGZ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_12315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86709">
        <property type="protein sequence ID" value="AKH86709"/>
        <property type="gene ID" value="AA958_12315"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_12315"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2589"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="293"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="380"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="416" mass="42993" checksum="7058899E769AF457" modified="2015-07-22" version="1">MVRAAPVIAPPQLWNRNFSLFFVARATSLLGDVMLPMAITVAMLDAGYGMSGVGYALAAHIAPFVVFVVVGGALNDRFSPRIMMVCSDVARLVLQGALAALLFLGTPGLGQILALLALVGLGSATFQPGVAGIVPRLTSQVQKANAAQETAESTMAVLGPALAGVLLAVASPPAVLAVDAFTYGVSGLCLMLMRGLSPSAAPTSDGRHSLRRELGEGWREFRGRTWLTAVVATFMLGALTVLGPNQTLGYSTIVEDHGKTSFGMVMSVFGLGSVVGGLAAARFRPTFPLRTGAVAYGGVVLAPLTVALGLPVSWVAAGYACAGAGGAFWLVMFHTTVQTHVPVEVLSRVHAFDVAGSLMMAPAGRAAAGPAGEWLGPRHVLLVSACMGVVVCAVLLLTRPINRLPRDPLSKERAPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NH26</accession>
    <name>A0A0F7NH26_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_08015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019854.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_08015"/>
    <dbReference type="EnsemblBacteria" id="AKH86603">
        <property type="protein sequence ID" value="AKH86603"/>
        <property type="gene ID" value="AA958_08015"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_08015"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1690"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="1">
        <location>
            <begin position="179"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="408" mass="44615" checksum="A6D1666EB8B12B73" modified="2015-07-22" version="1">MGEDFVDRSVGFGERLLGLLLDRARLLPPQLIAPLIADEVARIGGRDVSILLQDYAQERLVPLPGKKLHVSEAQAISDSQAGQAFLRAAPVEAPQAGGGVRVYLPLQDGSDQVGVMALTLDAVGDDIRRLLRRLAGLVADMLVTKSAYTDQFFLARRREPMSVSAEIQWNLLPPLAMTVPQVSVAGVLEPAYRVAGDSFDYALNDNILHIAVIDAMGHGLDAATMATVAIGAYRHARRVFVSLAEKYAFMDAAISQQFGPDHFVTAQLMHVNIATGQMELVNAGHPAPLLIREGKVVRRLESATTLPVGFGGEEPKVREHTLQPGDRVLCYTDGIIEEHVEHEEQFGEERLIGCVNRLREERSQSLRADLRRLSHTLKKQRGGRTSDDATLFMIEWRGGAADNLAVPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NHE7</accession>
    <name>A0A0F7NHE7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_32520</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019389.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_32520"/>
    <dbReference type="EnsemblBacteria" id="AKH86162">
        <property type="protein sequence ID" value="AKH86162"/>
        <property type="gene ID" value="AA958_32520"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_32520"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6864"/>
    <dbReference type="OrthoDB" id="1108236at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="19"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="268"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="304"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="338"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="362"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="403"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="436"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="15"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="467"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH86162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="489" mass="50138" checksum="940D7A6C5ED7329C" modified="2015-07-22" version="1">MTEPAPIPGLRGRFTIPSLAFGGILMAVMQTVVVPLLPDLPRLTGASAGTVSWTVTATLLAGAVLTPVLGRAGDMYGKKRVLISALTLMTVGSVMCALSSDITVIITARALQGAAAAVVPLSISILRDELPPERRGSAVAMMSSTVGIGAALGLPLAALVIQYADWHVMFWLTSALGALGVAAVAWAVRESPVREPGRFDVVGTLGLAAGLVCLLLGVSQGGQWGWTSGRILVLFPAAVVVLALWSWHQLRAKAPLVDLRLAARPRVGLPHVAALLTGFAFYANTLVTAQLVQAPKATGYGLELSIVATGLCLLPGGITMLLFSPVSARISEARGPRVTLALGAVVIACGYAVRIADSRDLWMIIAGAAVVSTGTTLAYSALPTLILRAVPAEQTASANGVNVLMRTIGQATSSAAVAAILVHHTSGVGGTQVATLHGYLLTFTMAGAIALVACAAALVIPRDEAAANPPRQARRRVPAVAPERTGKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NHF3</accession>
    <name>A0A0F7NHF3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA 2',3'-cyclic phosphodiesterase</fullName>
            <shortName evidence="2">RNA 2',3'-CPDase</shortName>
            <ecNumber evidence="2">3.1.4.58</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_13205</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + H2O = a 3'-end 2'-phospho-ribonucleotide-RNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11828"/>
            <dbReference type="Rhea" id="RHEA-COMP:10464"/>
            <dbReference type="Rhea" id="RHEA-COMP:17353"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:83064"/>
            <dbReference type="ChEBI" id="CHEBI:173113"/>
            <dbReference type="EC" id="3.1.4.58"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 2H phosphoesterase superfamily. ThpR family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.58" evidence="2"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020016.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_13205"/>
    <dbReference type="EnsemblBacteria" id="AKH86733">
        <property type="protein sequence ID" value="AKH86733"/>
        <property type="gene ID" value="AA958_13205"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_13205"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2779"/>
    <dbReference type="OrthoDB" id="1696971at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004113">
        <property type="term" value="F:2',3'-cyclic-nucleotide 3'-phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008664">
        <property type="term" value="F:2'-5'-RNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01940">
        <property type="entry name" value="RNA_CPDase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009097">
        <property type="entry name" value="Cyclic_Pdiesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014051">
        <property type="entry name" value="Phosphoesterase_HXTX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004175">
        <property type="entry name" value="RNA_CPDase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35561">
        <property type="entry name" value="PTHR35561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02834">
        <property type="entry name" value="LigT_PEase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55144">
        <property type="entry name" value="SSF55144"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02258">
        <property type="entry name" value="2_5_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LigT_PEase" evidence="4">
        <location>
            <begin position="9"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="176"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="HXTX 1" evidence="2">
        <location>
            <begin position="42"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="HXTX 2" evidence="2">
        <location>
            <begin position="137"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="42"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH86733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="200" mass="21589" checksum="569A859D5AEB877C" modified="2015-07-22" version="1">MRLFAAVVPPPEVLGELAEAVRRLRRLPGAERLRWVPREGWHITVAFYGEVPAGSVAELEERLARAARRRGPVGLRLAGGGRFSDTVLWAGAAGDVEELGRLAAGAAAAGHRTAGVPLAAKRGGGAARGRERRYRPHLTLARQRHRAGTDLTPFTESLRDFTTPHRNLTTLTLIQSHPPPPGHPGAQPRYEPVATWPLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NHF8</accession>
    <name>A0A0F7NHF8_9ACTN</name>
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        <submittedName>
            <fullName evidence="4">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_18015</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_18015"/>
    <dbReference type="EnsemblBacteria" id="AKH86859">
        <property type="protein sequence ID" value="AKH86859"/>
        <property type="gene ID" value="AA958_18015"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_18015"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3789"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxi_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="SSF48317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="163"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="acidPPc" evidence="3">
        <location>
            <begin position="66"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH86859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="240" mass="24807" checksum="6100CCD6F114997D" modified="2015-07-22" version="1">MAGAPPSGSNADVSVLFDINGVADSTPPWFDRGAAFLGEYGLIGMLGVLLVVCWWRARRRTGAVPVVTALLWGPLAAALALLANMPIRAIVERPRPFREHEGLEVLLPGTTGYSFVSDHTSVAMALAAGIFMASRRYGLAALALALLEALSRVYLGVHYPSDVVGGIALGTSVALLLAPAATAGLMPLVRRAPEWLVGDPEAADAGPDREPATGPGAVPAPRTEPLERGGGGRDGDELAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NHG2</accession>
    <name>A0A0F7NHG2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AA958_13615</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020029.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_13615"/>
    <dbReference type="EnsemblBacteria" id="AKH86743">
        <property type="protein sequence ID" value="AKH86743"/>
        <property type="gene ID" value="AA958_13615"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_13615"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2865"/>
    <dbReference type="OrthoDB" id="643917at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="90"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="172"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="35"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="367"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="400"/>
            <end position="407"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AKH86743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="612" mass="65953" checksum="058D863BDB9C6786" modified="2015-07-22" version="1">MRMFSGPPVERSLDFRGSAVRLLRTLRPDRTLIRVILVLGAAGVALTVAGPKLLGHATDLVVAGVYGDRVDTGSARASDGIDFDAVGRTLLWAALVYAAAWGLGLAQARLTAVVVQRAVFRLREEVEAKLSRLPLSYFDRHQRGEILSRTTNDIDNVGQSLQQTMSQIVTSLLTIAGVLAVMFWISPLLALVALVTVPLSITVATRVGKRAQPQFVAQWASTGKLNAHIEEMYTGHSLVQVFGRREEAAETFRKENDELFRAGYRAQFISGLIQPAMMCIGNLNYVLVAVVGGLRVASGALSIGDVQAFVQYSRQFSQPLGQIASMANLVQSGVASAERVFELLDADEQEPDAATPARPAEPVRGEVAFESVSFSYDPEKPLIEDLSLTVRPGQTVAIVGPTGAGKTTLVNLLMRFYEVAGGRILLDGVDVAEMSREELRAQIGMVLQDTWLFGGTIAENIAYGAPAGTPHEKIVAAAKATHVDRFVRTLPDGYDTVIDEEGTGVSAGEKQLVTIARAFLAEPAILVLDEATSSVDTRTEVLIQHAMAELRTGRTSFVIAHRLSTIRDADVILVMESGTIVEQGTHEELLASEGAYARLYQAQFAEPAAETI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NHI3</accession>
    <name>A0A0F7NHI3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_19055</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020220.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_19055"/>
    <dbReference type="EnsemblBacteria" id="AKH86889">
        <property type="protein sequence ID" value="AKH86889"/>
        <property type="gene ID" value="AA958_19055"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_19055"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4000"/>
    <dbReference type="OrthoDB" id="1677960at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041472">
        <property type="entry name" value="BL00235/CARNS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CbamoylP_synth_lsu-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040570">
        <property type="entry name" value="LAL_C2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18130">
        <property type="entry name" value="ATPgrasp_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18603">
        <property type="entry name" value="LAL_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="2">
        <location>
            <begin position="111"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH86889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="406" mass="44119" checksum="70FCCC26E5DC88B0" modified="2015-07-22" version="1">MLIVAAADRDAQAYRRWCLQNIAAHYDVALICEKEPTWQRPWITDIEVADPADEEALLAAGRALRRRHTVAGVMTWTEWYLVPTARLARSLSLPTTPPSALRRCRDKAAARAAFARGQVPSAVCVSVSTEAEAREAAQRVGYPVVLKPASLAASMGVTRADTDDELPFAYRHAAQAASRRGVESPRVLVEEYLDGPEISVECVTHKGRTTAVAVTHKTVGMPPHFEELAHVVDANDPLLPRVGPAANAALEALGVTDSVSHVEMRLVDGRPRLIEVNARLAGDMIGHLVQSATGIDLARAAADIACGHTPDLTPTRNRTAAIRMIYPAHSGTLTTREIDTDFAHRADWLERVTFQREPGDRLVLPPDGDMFTARIGFVITTGTTTAEAQARATEGYRNLTIRVAPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NHX6</accession>
    <name>A0A0F7NHX6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_27525</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020459.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_27525"/>
    <dbReference type="EnsemblBacteria" id="AKH87064">
        <property type="protein sequence ID" value="AKH87064"/>
        <property type="gene ID" value="AA958_27525"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_27525"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5800"/>
    <dbReference type="OrthoDB" id="386120at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519480" evidence="4">
        <location>
            <begin position="36"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="31"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH87064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="450" mass="49492" checksum="0C63683E73481554" modified="2015-07-22" version="1">MTHSASGSSIGRRSLLAGAGSVGAAAALAPVPASAGPSPAAAPAGGGGNASGNWPDPEPYGLADTRADLWPRDDNSFVLPLELRPRDEERGVVWMRDTYVNCFSVDGRPLYVATGTTRVPGLTTASPWNDGIFVWTARSLRGPWKLADTTGIRPDAEKGKVWSPEFAGENRPGRTVVAPWQEYWHDDMFGKRANAWAPEVHYFDGRWYIVACMGDHSRLVGSFMLVSEGEVEGPYRLVEGNLDKPFGDPVKGGPSFIEPGAYHHIDGSLYSEGGDAWLVLHNDLYAKFRDDMEDIVPATDLPRFEQQRYSPEPYLEGAYVFRHRGKYFLLHAAWNRASLDAYGSTRHAYEPGGAGRVQYQYDAVVAVADRFEGPYSRRWTAGVGAGHNNFFADAGGRLWATFFRNPNFGYWADPARIDDAAVPGVVRLEWTGGRDGRIYVQRRRGRTAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NIA5</accession>
    <name>A0A0F7NIA5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">von Willebrand factor A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_31630</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_31630"/>
    <dbReference type="EnsemblBacteria" id="AKH87174">
        <property type="protein sequence ID" value="AKH87174"/>
        <property type="gene ID" value="AA958_31630"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_31630"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6680"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011195">
        <property type="entry name" value="UCP010256"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008912">
        <property type="entry name" value="Uncharacterised_CoxE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05762">
        <property type="entry name" value="VWA_CoxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010256">
        <property type="entry name" value="CoxE_vWa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="187"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH87174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="369" mass="39494" checksum="7AB1CDEE1C3EA032" modified="2015-07-22" version="1">MLVGFARALREAGVPADGERVQAFLGAVDALGTARREVFWAGRLTLCGRAEDLAPYDRAFAAYFGDRAVPPRPPRTAPPPRVRRTAPAAVEAPGDAGDRTGPAAPAAARAGSAEVLRHRDIAGLTAAERAELHRLRTAFALRGEQRRTARRRPARRGAVDPRRTVRDLLRGGGEPAVLRRRAPARKPRRVVVLLDVSGSMSPYADALLRFAHAARHGRPARAAPATEVFTLGTRLTRVTRQLSHRDPDAALAAVGTAVPDWSGGTRLGETLRAFLDRWGQRGLARGAVAVVLSDGWERGDVTLLGAQARRLHRLAHRVVWANPRKARPGYEPLAGGMAAVLPHVDAFVSGHSLAALERLAAVVRGAADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NIY8</accession>
    <name>A0A0F7NIY8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_14925</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86777">
        <property type="protein sequence ID" value="AKH86777"/>
        <property type="gene ID" value="AA958_14925"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_14925"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3145"/>
    <dbReference type="OrthoDB" id="2076051at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046151">
        <property type="entry name" value="DUF6153"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19650">
        <property type="entry name" value="DUF6153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519541" evidence="2">
        <location>
            <begin position="37"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH86777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="177" mass="16938" checksum="C7ABE09C38436F23" modified="2015-07-22" version="1">MGPRRRPAGRLFVLLVLAVLAGVLGMHALGPGGAPAPERPTAMAPGHGGAEAPAAMPAQTPLPVPGTPEASAGHVPAAFVPAAQTPASPASHAPVEQTPVATPAGDACSHTDGGSGHLAHADRTCAAAGTSSAYAPPALAGALPGAPAAAPAPIAGPAAGLPDRTPPDLAELQLLRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MXU9</accession>
    <name>A0A0F7MXU9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acetoacetyl-CoA synthetase</fullName>
            <ecNumber evidence="5">6.2.1.16</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_01600</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.2.1.16" evidence="5"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014439.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_01600"/>
    <dbReference type="EnsemblBacteria" id="AKH81075">
        <property type="protein sequence ID" value="AKH81075"/>
        <property type="gene ID" value="AA958_01600"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_01600"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.351"/>
    <dbReference type="OrthoDB" id="141801at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030729">
        <property type="term" value="F:acetoacetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005914">
        <property type="entry name" value="Acac_CoA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01217">
        <property type="entry name" value="ac_ac_CoA_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACAS_N" evidence="4">
        <location>
            <begin position="66"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding" evidence="2">
        <location>
            <begin position="143"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="3">
        <location>
            <begin position="573"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH81075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="689" mass="74882" checksum="61B1B76C60580DCA" modified="2015-07-22" version="1">MPSQPPTEPSAPSAPSAGSAASEPPAALWRPGPERIDDAQLTRFHRWAAEHHGAPAPVPGDPEANYAALHRWSVAPDGGLERFWRAAAEWFDVRFSSPYETVLADAAMPGASWFPGARLNYAEHALRDAGTAAGPALLHVAEGAGPQPVSRAELRAQVGSLAAELRRLGVRPGDRVGAYLPNIPQAVVALLATAAVGAVWTSCSPDFGARSVLDRFRQVEPVVLVTVDGYRYGGKEHDRRETVAELRRELPTLRAVVHVPLLGTVPPEGALEWDALVATGAEPVFEQVPFDHPLWVLYSSGTTGLPKAIVQSQGGILLEHLKQLALHCGLGPGDRFFWYTSTGWMMWNFLVSGLLVGATVITYDGSPGHPDVAAQWRVAERTEATFFGTSAAYVMACRKADVHPGRDLDLTRVRCVATTGSPLPPDGFRWIHDEFHRAGPAGPADMWIASVSGGTDVCSCFAGAVPTLPVHIGELQAACLATDLQAWDPAGEPVTDEVGELVVTQPMPSMPVRFWNDPDGERYRDSYFSTYPGVWRHGDWITLTSRGSVVIHGRSDSTLNRQGVRMGSADIYEVVERLPEVRESLVIGVEQPDGGYWMPLFVQLTTDARLDDGLRGRIRAALREQLSPRHVPDEVIEVEGVPHTLTGKRLEVPVKRMLQGTPLEKAVNPGSVDRVDLLRFYERLARSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MYH9</accession>
    <name>A0A0F7MYH9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_02840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014648.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_02840"/>
    <dbReference type="EnsemblBacteria" id="AKH81285">
        <property type="protein sequence ID" value="AKH81285"/>
        <property type="gene ID" value="AA958_02840"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_02840"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.607"/>
    <dbReference type="OrthoDB" id="313921at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050043">
        <property type="term" value="F:lactate racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043166">
        <property type="entry name" value="LarA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018657">
        <property type="entry name" value="LarA-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09861">
        <property type="entry name" value="Lar_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lar_N" evidence="1">
        <location>
            <begin position="30"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="519" mass="58682" checksum="E3ADDBD11C7AD445" modified="2015-07-22" version="1">MLEVDERTPPLLVHEGENFRLERLPHGTRVIYPPDSLPGIRDLDGVIRRALLEPHGSEPLPELLFAGMRLTIVFDDLSLPLPPMRRPDVRQRIIEQVLEMAAVKGVDDVELIAANALHRRMTPAELQHVVGDRVFRSFFPQHLTNHDAEDRDNLVHLGDTAEGEEVEINRRAAESDLVVYVNITSTAMSGGPKSVSVGLASYRSIRHHHNVHTLRHSRSFNDPPKSAMHHSYNRMHDLIGGQVKVFTVETTLNNDTFPSATRFLNKREWEWNYGDQAAYLASRRGNSLMTPSMRRRLWHKTEAPYGVTGVNAGAPSEVHPITLRNVHRQQLTEVQGQADVAVYGLPYICPYNVNSVMNPILTMCLGLGYFFNLYLNKPIVREGGVGIFYHPMPNEFHPVHHPSYIDFYEEVLAETTDPAVIEAKFEKQFATDPWYTHLYRKSYAYHGVHPFYMWYWGAHAMQHLGQVIFVGADRSAASRLGVQSASTLNDALQLASQTVGTSPSITYQHMPPLTLASVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MYS4</accession>
    <name>A0A0F7MYS4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Class IV aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_03420</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014748.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_03420"/>
    <dbReference type="EnsemblBacteria" id="AKH81390">
        <property type="protein sequence ID" value="AKH81390"/>
        <property type="gene ID" value="AA958_03420"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_03420"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.726"/>
    <dbReference type="OrthoDB" id="1275805at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008696">
        <property type="term" value="F:4-amino-4-deoxychorismate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01559">
        <property type="entry name" value="ADCL_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017824">
        <property type="entry name" value="Aminodeoxychorismate_lyase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018300">
        <property type="entry name" value="Aminotrans_IV_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="SSF56752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00770">
        <property type="entry name" value="AA_TRANSFER_CLASS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH81390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="279" mass="29447" checksum="3E0DCEE46B1C9DB9" modified="2015-07-22" version="1">MKVWLDGGLREVADARVSVFDHGITVGDGVFETLKATGGTAFALTRHLERLARSARGLGLPEPDLDEVRRACAEVLAAEPVAHGRLRITYTGGAAPLSSHRSDPDDSRPTLAVALAAADPRPDETDAVTVPWTRNERGAVAGLKTTSYAENVVALARAHEGGASEALFANTRDRLCEGTGSNVFVVLGGELHTPPLASGCLAGITRQLLLEWTGARETDLPFSVLAEGGEVEEVFLTSSLRDVQAVRHLDGRELPGARGPVTAKAMQVFAERSAGDIDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MZF6</accession>
    <name>A0A0F7MZF6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_01725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014460.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_01725"/>
    <dbReference type="EnsemblBacteria" id="AKH81096">
        <property type="protein sequence ID" value="AKH81096"/>
        <property type="gene ID" value="AA958_01725"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_01725"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.377"/>
    <dbReference type="OrthoDB" id="1387978at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="280" mass="30702" checksum="C8462DE808101AD0" modified="2015-07-22" version="1">MIRVMTWNLWWRFGPWQERSKAILETLRDERPDVVGLQEVWGRGADNQAGWLANELGMHWAWAPSPEPGRWQRRIDDPTVEVGNAVLSRWPITEQDTAVLPAGEEEPDGQQALYARVAAPGGVTVPFFTTHLISYPHASATRTAQVSALARFVHERRGDGDFPPVVTGDFNAEPDSDEMRLLCGTKTAPAVRGQVLLDAWRYAHPTAVGATWDLANPYAARTLEWHTRIDYVLVGPPGPVGEGHVRDVRRAGDGPVDGVWPSDHCAVVADLATEAGGPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N090</accession>
    <name>A0A0F7N090_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Alanine--tRNA ligase</fullName>
            <ecNumber evidence="10">6.1.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Alanyl-tRNA synthetase</fullName>
            <shortName evidence="10">AlaRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">alaS</name>
        <name evidence="14" type="ORF">AA958_03215</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala)</text>
            <dbReference type="Rhea" id="RHEA:12540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:9923"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78497"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.7" evidence="10"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014710.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_03215"/>
    <dbReference type="EnsemblBacteria" id="AKH81351">
        <property type="protein sequence ID" value="AKH81351"/>
        <property type="gene ID" value="AA958_03215"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_03215"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.685"/>
    <dbReference type="OrthoDB" id="91428at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004813">
        <property type="term" value="F:alanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006419">
        <property type="term" value="P:alanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00036_B">
        <property type="entry name" value="Ala_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002318">
        <property type="entry name" value="Ala-tRNA-lgiase_IIc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018162">
        <property type="entry name" value="Ala-tRNA-ligase_IIc_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018165">
        <property type="entry name" value="Ala-tRNA-synth_IIc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018164">
        <property type="entry name" value="Ala-tRNA-synth_IIc_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023033">
        <property type="entry name" value="Ala_tRNA_ligase_euk/bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01411">
        <property type="entry name" value="tRNA-synt_2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00980">
        <property type="entry name" value="TRNASYNTHALA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101353">
        <property type="entry name" value="SSF101353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="SSF55186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00344">
        <property type="entry name" value="alaS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50860">
        <property type="entry name" value="AA_TRNA_LIGASE_II_ALA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10 14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 10" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II_ALA" evidence="13">
        <location>
            <begin position="1"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="852"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="740"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="572"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="576"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="674"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="678"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AKH81351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="889" mass="95209" checksum="FC2F7550FB2E0655" modified="2015-07-22" version="1">MESAEIRRRWLRFFEERGHTVVPSASLIADDPTLLLINAGMVPFKPYFLGEATPPYKRATSVQKCIRTPDIDEVGKTTRHGTFFQMCGNFSFGDYFKEGAATLAWELLTSSQDAGGYGLDPERLWITVYEDDDEAERIWRDVVGVPPERIQRLGKEENYWDMGVPGPCGPCSEVNYDRGPEFGEAGGPAVNGERYVEIWNLVFMQYVRGPGKGKDYPILGDLPQQNIDTGLGLERLAMILQDVHNMYEIDTSRAVIDKAEELTGVRYGAADHSDVSLRVVSDHMRASVMLIGDGVTPGNEGRGYVLRRIMRRAVRNMKLLGADRPVVGELVDVVISTMGEQYPELVADRKRIESVALAEEARFLKTLKAGTNVLDTAVTEARSAGSGVLPGDKAFLLHDTWGFPIDLTLEMAGEQGLTVDEDGFRRLMKEQRDRAKADAAAKKTGHADLSAYREVADSAGATEFTGYTHTAAESTVVGLLVGGAASPAATEGDEVEVILDRTPFYAEGGGQLADTGRIRLGSGAVVEVRDVQQPVPGVSVHKGVVQVGEVTVGEPAQAAIDVSRRRAIARAHSATHLTHQALRDALGPTAAQAGSENAPGRFRFDFGAPAAVPGGVLGDVEQKINEVLARELDVHAEVMSMEDAKKQGALAEFGEKYGDRVRVVTIGDFSKELCGGTHVHNTAQLGLVKLLGESSIGAGVRRVEALVGVDAYNFLAREHTVVHQLTELLKGRPEELPERISGMLARLKDAEKEIEKFRAEKVLQAAAELAEGARDVGGVALVAARVPDGTAAEDLRKLVLDVRGRIPGDRPAVVALFSVAGGRPVTVIATNEAARERGLKAGDLVRTAAKTLGGGGGGKPDIAQGGGQDPQAVGEAVAAVERGVAEAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0A2</accession>
    <name>A0A0F7N0A2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_07205</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015395.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_07205"/>
    <dbReference type="EnsemblBacteria" id="AKH82045">
        <property type="protein sequence ID" value="AKH82045"/>
        <property type="gene ID" value="AA958_07205"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_07205"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1510"/>
    <dbReference type="OrthoDB" id="117817at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519107" evidence="2">
        <location>
            <begin position="29"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="627"/>
            <end position="654"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH82045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="682" mass="73234" checksum="DE30095A8B95B424" modified="2015-07-22" version="1">MRARLTVLTTVAALALGLLAPTALAGQAAESPRSVRAEQPRGGDRAGCDPIGPAECLLPFPNDWYTERDPRTDTGRRIAFAPSAMPANAAGTRIDPAEWNRSDGFSPGSMILAHVPGVDLGETRAAPLTDIGASLDRDAPIVLLDAGTGERHPYWAELDANATDPARRALIVRPARNLAEGHRYVVALRRLRDAGGRTLPAPDAFRRVDGPALRKGDPLYERQRDHRRVRRDLARAGVTSRGLYLAWDFTVASERSLSERLLHIRDDAFAGLGKGVPEHLVYEVKDHPADDPVARTVRGVYNVPSYLDAPGGPPGSGFHRTGGGKDALPARLPGNNQVVPFQCEIPRAALGGPGEGGRAARPVLYGHGLLGNETQVGSRTQRELAVRGNFVMCATKWQGMADEDIPFVASTLQDLSRFPAVADRLQQGVLNTLWLGRLMRHADGLAADDAFRGAGGASAIDVRAGLGYAGHSQGGIMGGIYTAVAQDSTRSVLGVPGMNYSTLLNRSVDFAPFQQILDRAYPDKLRQQLGFALMQMVWDRGEANGYAQHMTSDPLPRTPRHQVLMHVAYGDHQVSPTAAEVQARTVGARIHAPAVAEGRSPDEEPYWGLRHLRYPYAGSGMLVWDSGSPYQPLTNTPPGEGRDPHSDPRDEPAAQRQMAGFLNTGRIVDVCGDAPCTAAPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0J1</accession>
    <name>A0A0F7N0J1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UDP-N-acetylglucosamine 1-carboxyvinyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_07800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015505.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_07800"/>
    <dbReference type="EnsemblBacteria" id="AKH82155">
        <property type="protein sequence ID" value="AKH82155"/>
        <property type="gene ID" value="AA958_07800"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_07800"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1641"/>
    <dbReference type="OrthoDB" id="537477at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001986">
        <property type="entry name" value="Enolpyruvate_Tfrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036968">
        <property type="entry name" value="Enolpyruvate_Tfrase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00275">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="SSF55205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="13"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH82155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="509" mass="55879" checksum="A188DCEEC6EEFDF9" modified="2015-07-22" version="1">MADDYLVRIGRLIRDARQHRGWSQSQLAAALGTSQSAVNRIERGHQNISLEMIARIGEALDSEIVALGTAGPMHLRVSGGRRLSGAIDVKTSKNACVALLCATLLNSGRTVLRRVARIEEVFRILEVLNSIGVRTRWINDAADLEVVPPAELDLDSMDNAAARRTRSVIMFLGPLLHRVERFKLPYAGGCDLGTRTVQPHMAVLRRFGLDVTATEGVYHCEVVSDVGPDRAIVLTERGDTVTENALLAAARHDGVTEIRNASSNYMVQDLCFFLEHLGVRVDGVGSTTLRVHGVPYIDRDVDFSPSEDPVEAMSLLAAAVVTSSELTVRRAPVEFLEIELSVLEEMGLDLDRTPEYAADNGRTRLVDLTVRPSKLQAPIDKIHPMPFPGVNIDNVPFFAAIAASAQGSTLIHDWVYDNRAIYLTELTRLGAGVKLLDPHRVLVEGPTRWRETEMMCPPALRPAVVVLLGMMAAEGTSVLRNVYVINRGYESLADRLNSVGARIETFRDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-10-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N106</accession>
    <name>A0A0F7N106_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nitroreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_08725</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015648.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH82300">
        <property type="protein sequence ID" value="AKH82300"/>
        <property type="gene ID" value="AA958_08725"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_08725"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1841"/>
    <dbReference type="OrthoDB" id="2076602at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="2">
        <location>
            <begin position="48"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH82300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="211" mass="22812" checksum="014746FC44831B91" modified="2015-07-22" version="1">MTLLPIADVVEYVEGTRRRAPTAGARAQWPAPRGADRPAPLLPARMLDRRRTIRDFTTQPVAEDRVRALLATAFATHRRARPASADEQEYAVIVVRRSPGEPPQGVYATPAGTRPLTDDAWLPLLADHYTDAAVLFLVCGTARRARADYPRHLVGAGALTHALWLAALSAGLGGWVFGRSCHRATVAAGRQPAGTRHLLTLAVGHPKETLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N1C7</accession>
    <name>A0A0F7N1C7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF397 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_08980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015687.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_08980"/>
    <dbReference type="EnsemblBacteria" id="AKH82340">
        <property type="protein sequence ID" value="AKH82340"/>
        <property type="gene ID" value="AA958_08980"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_08980"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1891"/>
    <dbReference type="OrthoDB" id="1996962at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="13"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="71" mass="7597" checksum="4B96A97E6A469CA1" modified="2015-07-22" version="1">MNHMNDASTLAVAWWKSSHSGAQADCVEVGIVDERAVAVRDSKDPAGPALLLTRDQFAGLVDSVRAGRFEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N1U7</accession>
    <name>A0A0F7N1U7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Lysine N-acyltransferase MbtK</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Mycobactin synthase protein K</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_10370</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Acyltransferase required for the direct transfer of medium- to long-chain fatty acyl moieties from a carrier protein (MbtL) on to the epsilon-amino group of lysine residue in the mycobactin core.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Siderophore biosynthesis; mycobactin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the IucA/IucC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015907.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_10370"/>
    <dbReference type="EnsemblBacteria" id="AKH82565">
        <property type="protein sequence ID" value="AKH82565"/>
        <property type="gene ID" value="AA958_10370"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_10370"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2185"/>
    <dbReference type="OrthoDB" id="856726at2"/>
    <dbReference type="UniPathway" id="UPA00011"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016881">
        <property type="term" value="F:acid-amino acid ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019290">
        <property type="term" value="P:siderophore biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019432">
        <property type="entry name" value="Acyltransferase_MbtK/IucB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007310">
        <property type="entry name" value="Aerobactin_biosyn_IucA/IucC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022770">
        <property type="entry name" value="FhuF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037455">
        <property type="entry name" value="LucA/IucC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34384">
        <property type="entry name" value="PTHR34384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06276">
        <property type="entry name" value="FhuF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04183">
        <property type="entry name" value="IucA_IucC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01006">
        <property type="entry name" value="AlcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AlcB" evidence="6">
        <location>
            <begin position="6"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH82565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="777" mass="85569" checksum="3676365D19255E6A" modified="2015-07-22" version="1">MELTLRPLDPVLDAPLLHTWVTDPKAAFWLMQGCTPEEVEKEYARIAADPHHDAWLGLADGTPAFLAERYDPAHRELTGVYAAEDGDVGMHFLTAPAGTPVHGFTRAVITAVMEWLFADPAVRRVVVEPDARNTAVHALNEAVGFRVARRVRIPGAPGKPGKEALLSFCTREQFAASQAPAPPDPTGHLTPGHWAEATRRLLAKAIGEFTHERLLTPEPRGVGSYALRAGDAEYRFEARRYALDHWRVDPRTVTRHAPGDPPEGSAPDALRFFAGLREPLGLSPEVLPVYLEEITSTLASSAYKLAGPEDPDLATADFQRIEAGMTEGHPCFVANNGRLGLGAADYRAYAPETGARTRLVWLAAHRDRAAFTCAADLDYDTLLRAELGPAVLDRFAARLRALGLAPDDYLLMPAHPWQWEHKLSVTFAGEVAARRLVYLGESEDTYQPQQSIRTFFNTSAPRKHYVKTALSVLNMGFMRGLSAAYMEATPAINDWVAGLVDQDEVLRGTGLVVLRELAAAGYRHEAYEAATAPGSPYRKMLAALWRESPVPRLAEGERLATMAALLHTDRAGRPLAAALVEGSGLAPEVWLRRYLDAYLTPLLHAFYAYGLAFMPHGENVILVLDEAGAVVRALFKDIAEEVVVMDPDLPLPPAAERIRAEVPDDMQLLSVFTDVFDCFFRFLAPLLDEAGVLGEEDFWRTVAECARDYRAAVPDLADRFERHDLFAPEFALSCLNRLQLRNNRQMVDLTDPSAALQLVGTLRNPLAPYRPRTPTPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N213</accession>
    <name>A0A0F7N213_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AsnC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_10815</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015975.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_10815"/>
    <dbReference type="EnsemblBacteria" id="AKH82635">
        <property type="protein sequence ID" value="AKH82635"/>
        <property type="gene ID" value="AA958_10815"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_10815"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2275"/>
    <dbReference type="OrthoDB" id="1844486at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="5">
        <location>
            <begin position="2"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH82635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="171" mass="18023" checksum="D3E2F8FF921E8550" modified="2015-07-22" version="1">MIDQLDGRLLELLANEPRIGVLEASRRLGVARGTTQARLDRLRSGGVIRGFGPDVDPAALGYPVTAFATLEIKQGQGTDVRSHLARVPEVLELHTITGHGDMLCRLVARSNADLQRVIDLVVGFDGIVRASTAIVMENPVPLRIVPLVRQAAGGSPAGGSPGGGPTERPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2E0</accession>
    <name>A0A0F7N2E0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oligo-1,6-glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_01315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014392.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_01315"/>
    <dbReference type="EnsemblBacteria" id="AKH81027">
        <property type="protein sequence ID" value="AKH81027"/>
        <property type="gene ID" value="AA958_01315"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_01315"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.291"/>
    <dbReference type="OrthoDB" id="1573900at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="1">
        <location>
            <begin position="16"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="528" mass="56862" checksum="E8DAD74D1A9C975D" modified="2015-07-22" version="1">MTPSPPAWLADAVLYQIYPQSFADSDGDGIGDFAGIEQKLDHLAWLGINTVWINPCFASPFHDAGYDVADFLTVAPRYGTNDDLAALVGSARRRGIRVLLDLVAGHTSDQHPWFTASAGDPGDHRYIWAPEDLRPPGFQPSPGSRPGWYRPNFFPSQPALNFGYARPDPAEPWRLPVDADGPRANRQALRDIMDHWLALGLAGFRVDMAASLVKDDPGHAETAKLWTELCGWLDGAHPRAVLLSEWGDPGTAVPAGFHGDFFLQFGGDDDGLPLRSLWNNDAGTVNEEWAPARPYFDAEGAGTPRTFLTAWRAAADAIGDAGFAVLPSSNHDFSRLACGPRTAEQLPAAFVFQLTWPTLPAIHYGDEIGMRYLPGLPDHEGSALGPRYNRAGSRTPMQWDSSANAGFSTAAADRLYLPLDPDPDRPTVAAQQADEKSLMHLVRRLIALRKAAPELGVSGGVEVLYAGYPLVYVRGGRYLVVVNPGRTPATAALPAGVRCTALEVSGVTLSDAGEIGAAGFGYGVFRVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2E9</accession>
    <name>A0A0F7N2E9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ArsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_07950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015526.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_07950"/>
    <dbReference type="EnsemblBacteria" id="AKH82176">
        <property type="protein sequence ID" value="AKH82176"/>
        <property type="gene ID" value="AA958_07950"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_07950"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1674"/>
    <dbReference type="OrthoDB" id="1617768at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="4"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="117" mass="12458" checksum="60FBE3F140A7D7F6" modified="2015-07-22" version="1">MVDQPPADGEVVDSVLAALADPTRRQMLDLLSARGQATATTLAGGLPISRQAVVKHLAVLDAAGLVGSVKVGREVRYAVRSEALDATARWMAALASDWDRRLARIKRIAEAAERDAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2F6</accession>
    <name>A0A0F7N2F6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Branched-chain amino acid ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_01410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014407.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_01410"/>
    <dbReference type="EnsemblBacteria" id="AKH81042">
        <property type="protein sequence ID" value="AKH81042"/>
        <property type="gene ID" value="AA958_01410"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_01410"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.311"/>
    <dbReference type="OrthoDB" id="776281at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028081">
        <property type="entry name" value="Leu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13458">
        <property type="entry name" value="Peripla_BP_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peripla_BP_6" evidence="1">
        <location>
            <begin position="41"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="418" mass="44777" checksum="073592B99440D989" modified="2015-07-22" version="1">MGHPWSKAAVATATVVAGSLLAGCGGGGPGSGGGKISDGGITLGVLTDLSGVYAELAGEDAVTAVEMAVADFEKKHGGDAVTDDIEVISADHQNKPDVANTQARDMYDREKADAVFDVPTSSAALAVANVAAQSKKLYFNIGAATTELAGESCNPYTYAWAYDTYMLANGTGTEVTKQGGESWYLIYPDYAFGQDMEKEFSTAIEEAGGEVVGKDPTPFPNDNFSTFLLKASAKKPAPDVLGTLQAGGDLVNVVKQYQQFKLKDKDIQLAIGLMFDTDIKAIGQDKLAGTMFTSPWFWNVDEESRKWAERFREKAGTWPTFDHAANYSAATHYLEAVQRAGTDDADEVNKELEGMKFDDFFARNAEVRAADHRVVHDAYLARVKDPADSETEGDFTEKVETIPAAEAFGPVSPDCSMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N335</accession>
    <name>A0A0F7N335_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sugar-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_02760</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014635.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_02760"/>
    <dbReference type="EnsemblBacteria" id="AKH81272">
        <property type="protein sequence ID" value="AKH81272"/>
        <property type="gene ID" value="AA958_02760"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_02760"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.591"/>
    <dbReference type="OrthoDB" id="1046649at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006584">
        <property type="entry name" value="Cellulose-bd_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005084">
        <property type="entry name" value="CMB_fam6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012938">
        <property type="entry name" value="Glc/Sorbosone_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022409">
        <property type="entry name" value="PKD/Chitinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000601">
        <property type="entry name" value="PKD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035986">
        <property type="entry name" value="PKD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011041">
        <property type="entry name" value="Quinoprot_gluc/sorb_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029010">
        <property type="entry name" value="ThuA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03422">
        <property type="entry name" value="CBM_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07995">
        <property type="entry name" value="GSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06283">
        <property type="entry name" value="ThuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00606">
        <property type="entry name" value="CBD_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00089">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49299">
        <property type="entry name" value="SSF49299"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50952">
        <property type="entry name" value="SSF50952"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51175">
        <property type="entry name" value="CBM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50093">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519193" evidence="2">
        <location>
            <begin position="31"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="3">
        <location>
            <begin position="730"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="domain" description="CBM6" evidence="4">
        <location>
            <begin position="925"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="3">
        <location>
            <begin position="1068"/>
            <end position="1151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH81272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="1151" mass="123754" checksum="DA7CADFA25063388" modified="2015-07-22" version="1">MRRLARPPLSPIAVLAALLALLLGTASATAAPQDEEAGFRVLVFSKVTNFYHDSIPAGIEAVEKLGEEHGFEVDSTDDAAAFTEENLANYEAVVFNNTNSTPESGDLLDAGQRAALQSYIQGGGGWLGLHAASASERDWDWYEGLVGAIFDKHPVPQTGRIKVLDNTHPSTKGLPQLWERNEEWYNWRANPTGKVHTLAQIKVRDGITGLDEGVDHPFSWCQKYDGGRSWFTAGGHDASSFDEPLFLKHLLGGIRWAAGDAPGDCSATQTGNFQRTPLVTSDLADPFELAVAPDRRVFYAQRTGELKVVDQETLQVTTALDFDYTPEMTSQSDGLLGLTLDPDFARNNWIYLLHSDKEKNLINLSRFTMKGNTADPASQKVLLTVPTWRGEGRANVHMAGSLTFDTKGNLYVATGDNTDPFESSGFTPIDEREGRRAWDAQGTAGNTNDLRGKVLRVTPTNGGGYTIPKGNLFRQGESKTRPEIYAMGLRNPFRITTDPISGALLVADYGPDARSADPNRGPEGTVEYNRITKAGNQGWPYCIGNNTPFNDYDFAAGKAGEKFDCSAPVNDSPNNTGKTELPPAQPATVWYAYSASQEFPELGTGGGGPMSGPVYDYDPENDSPYKFPEYFEGKWITYELTRKWFKTFSFQEKDQQFEDPRFAPVKKGDLQSINGIFGDMSWVQPFEADFGPDGSLYVIDFGEGSGTGRGGSNEKAGIYRIDYVAEGRPPVAKLSASADSGPAPLTVEFSSEGSHSPGDDPITYAWDFDGDGTTDSTDPHPTHTYTEKGRFTARLTVEGPPERTAMAVHEVTVGNTRPEVKVTTPADGTAFDFGDTVPYKVEVSDAEDGDIDCSRVVVQTQLGHDDHLHPLDNLTGCEGEFKTDPGDSHGPGQNLYYGISAQYEDDGAEGVPSLVGSDSLSLRQKFREAEHHNGTGGANGGVETLAREDSSGGKRLGEIEHGDWIVLDPGTPSGIDSVTVGASSGGLGGDVEFRANAPDGELLGKATIPNTGDFAKVVSPTVPLTDPGGVEKVYLVFTNPAWTPSSPDLMALDWLHFNGRGAEKESAAKVTVTASPESATAPAEFSFEGAVTLPEGRTATSYHWTFGDNATGDGAATATHTYTGKGTYTAHLTVTDDTGNLTTGAVQVTVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3E5</accession>
    <name>A0A0F7N3E5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_06400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015252.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_06400"/>
    <dbReference type="EnsemblBacteria" id="AKH81899">
        <property type="protein sequence ID" value="AKH81899"/>
        <property type="gene ID" value="AA958_06400"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_06400"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1336"/>
    <dbReference type="OrthoDB" id="1262147at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="504"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="533" mass="58430" checksum="54F0488C3238D2C1" modified="2015-07-22" version="1">MTAAQHDRAVPPEDLSATERGLWEAFQEGATYDLRSRDPGQNDPAGLHIWGPERSVRASLLARLLLHGPPARPGRVSSLKLAGAYVTGTLDLSGGSVEPYVELRNCRFENEMLLPECSFATLRLVECSVPRLEAARLTTSGDMHMPRCTVDGGIRLTDAHIGTDLLLSQLTVGRDRRGVAVAADGITVGQDLQADLLQAHGELRMRGATVGVSLNLSGSVLRNPYGKRALNAPQLTVERSLHMGPAAVPEAATGGATPPYGISGHTPPRGTRMQRFECHGGLRLDDGRFGDSIDLDGARFVMDPEQEMSLRRIQTPELRFMGREPEGGRVVLSGARVVNLRDKYTSWPGPGRLAMAGFFYEHLIPVGAFPLVHRLEWVEAATPEFSPEPYELLAAVLRNTGEDHEAREVMLAKHRRQRETLPVTGKAWGLLQDWTVAYGYRPTRAVVWMAVLWAVGSLHFARQEPRALRPGEGPEWSPPLYVLDLLLPVIDLGQDNAWHQSGHYQWTATVLVLAGWVLATTVAAGVSRALRRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N404</accession>
    <name>A0A0F7N404_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_07565</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015463.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_07565"/>
    <dbReference type="EnsemblBacteria" id="AKH82113">
        <property type="protein sequence ID" value="AKH82113"/>
        <property type="gene ID" value="AA958_07565"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_07565"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1585"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011528">
        <property type="entry name" value="NERD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08378">
        <property type="entry name" value="NERD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50965">
        <property type="entry name" value="NERD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NERD" evidence="4">
        <location>
            <begin position="12"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="199"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="527"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="496"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="817"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="894"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="895"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="559"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH82113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="1506" mass="165901" checksum="31733F47D7B79B88" modified="2015-07-22" version="1">MKKDRWTAVAPSEYPHEQAALERILTPLPDDGPWRAWSNFTFVSQTGHVREVDLLVVTPGGVHMIELKSLHGRVERRGGQWVQIPPGNRRGYGRGLGDPLRLTNQKSKELASLLRRYGARVYVTEGVCFTEDGLDLALPPHELNAHIYNGVPALLAELRLPPREDRFRISSQASTGIGRALTQVGIQQVVREAKVGPFILDKRPFDTGVTWADYAGRHEQLSETVRVRVHLRPRNSSSEARKALVEAARREADTLKRIHHPAVVRIRDYYPSDHEAGPALTFDHHPERLHLDEFLDRWGEVLNLEDRLALVRQIAEAIKYAHAKRLYHRALTPRSIHVIPRCKAAEGRELSEEERWRQPMMQVSDWQLASRTITSSGVSLAPSTVSDGSVGDASDPYLAPELTAPKADPARMDVYGIGTLAYLLITGSSPAGTRAELQASSERGERLAPSAVRDGIPPFLDDLIDTATAQQPDRRLDAVSDFLEMLAAVEEDLRPAAVQEEEQPEQEPADDPDPLEVPPGTLLQGRWRVRRRLGTGSTARALLVLDERQGKSDAFAVLKVALDDDKSEALQREAETLDRLRDSSIIRLLVPGTFTVGGRTVLATEYVGNIKAEADDKRDDRTARDETMARVLGRQGRLTMDELERYSDNLFNALYYLEGEGVWHRDIKPDNIAIRIRPNGTRQALLLDFSLASVSARETGAGTAGYLDPFVGTVMRNLYDDAAERYALAATLHQMASNELPQWGDGSVTPRMTEPKEWPYPTIASEGFEDELRDGLTEFFRKALARDAKQRHKDLREMRTSWQRVFLDAQRLAASAGHESLRRQGQSSAPEGEADTAELRNQLAEVATRDTPLVRAGLTPSAYSILRDMKLTTVGEFLDRASRTFINRPGLGARTRTEIQRRQKEWRARLGSQPEPQPSPSPQERTLPEARIEHIVGLGPDVQDIDHLLARIVPPAAGRKKRLHEVAVHLLRAPGADGTLPDLPVWPLQKDAAQAVGFADQSTFSRELKKLRKLWAEDEGLLEVRAAVLEQLRTLGRVASVDALAGWLLGTRGYSLGDPEVRRAAAFAVLRALIEREQQLSVGDGAFQHFAPYKATDPVRRAGFLALEVDPDNEADGPDTPAAPALLSYVKRLGDAADRLAGRDSLPGSSTVLAELSAVRLPEGDFSWDDRRVATLAAQASQNAALSPRLEIYPRDLGLIRALRLTQAGLVRVLPGLPEKQQPGLPLREVLERVNDRFPALAALAGMKDRPEELLKALREAGFDLKYAADKKAFLPRKFEAVLSYTSAFSGSGSGTGGPLDPESAAALADAQLAGAARRDGFRVLTVRARSAPAVGRELRRQYGARAVSVTELFLKGLRGELTPGRAMPAWEVVVRADVLPAGQRPTGFTNLVGAVWQAVQGVLEAELAASAPAPTSGDGRDAPVLLADAAVFARYDGMHVLDRLTALARRGGRPLWVLVAQDDETAVPKLAGRPVPYLEAQQEWIPIPKSWTRMHEPTVLEGVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N473</accession>
    <name>A0A0F7N473_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amino acid decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_07990</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4 5">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the group II decarboxylase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015533.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_07990"/>
    <dbReference type="EnsemblBacteria" id="AKH82183">
        <property type="protein sequence ID" value="AKH82183"/>
        <property type="gene ID" value="AA958_07990"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_07990"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1685"/>
    <dbReference type="OrthoDB" id="1478871at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021115">
        <property type="entry name" value="Pyridoxal-P_BS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00392">
        <property type="entry name" value="DDC_GAD_HDC_YDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="3 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4">
        <location>
            <position position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH82183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="467" mass="48435" checksum="4866657721682A90" modified="2015-07-22" version="1">MHPALAADLDRFDRLLDAARARAVAALRGLADRPVAAPAPHAPGPYEPLPERGAGGVAALARFGERWEPGLSGSAGPRYLGFVTGGATPAAVAGDWLVGAYDQNVVAAGDSAATDLERETVGWLRELFGLGEAHAGAFVSGATMSNAAGLAVAREWLGERLGISVADAGAGALGEVAVLSGAAHSSVPKALSLLGLGRDALRAVPLLPGREAVDVDRLAAELAALDGRPAIVVANSGTVNTVDFDDLRAIAALRERYPFWLHVDAAFGAFAALSPEHAHLVAGLDAADSVCVDLHKWLNVPYDAAVQFTRRRDLQVRVFRNAAAYMAQPGDDPDFVHLTPENSRRLRALPAWLTLAAYGREGHREVVERNAALARRFGSGVAGGSGGGLRLLAPVRLNVVCFTLAAEPTRERVAALAAAVAASGEAVVTPTVYGGTHGLRAAFSNWRTGPEDADRAVTAVLTAARSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N499</accession>
    <name>A0A0F7N499_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_11975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016166.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_11975"/>
    <dbReference type="EnsemblBacteria" id="AKH82831">
        <property type="protein sequence ID" value="AKH82831"/>
        <property type="gene ID" value="AA958_11975"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_11975"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2520"/>
    <dbReference type="OrthoDB" id="1538944at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025968">
        <property type="entry name" value="YwqJ_deaminase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14431">
        <property type="entry name" value="YwqJ-deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="167" mass="17804" checksum="DEBD33EECD31D727" modified="2015-07-22" version="1">MGTGTGPAADPRTDWRDTAPGDGVPRLTSRRDGVLPAVGAALSVRGQTLTCTAGRADQGPLLHPLVQDFLDTLSSGRRERFTGRCPEAVLLSRHLTAVEAGRSKRAARKPLSAGEARRALKQAKITARHIREDGDPLHGRYAPPCRSCTALLTHFGVRTVGDAHAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4H9</accession>
    <name>A0A0F7N4H9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Butyryl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AA958_16590</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNQ-509</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016865.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_16590"/>
    <dbReference type="EnsemblBacteria" id="AKH83560">
        <property type="protein sequence ID" value="AKH83560"/>
        <property type="gene ID" value="AA958_16590"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_16590"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3491"/>
    <dbReference type="OrthoDB" id="357522at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01153">
        <property type="entry name" value="ACAD_fadE5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025878">
        <property type="entry name" value="Acyl-CoA_dh-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020953">
        <property type="entry name" value="Acyl-CoA_DH_N_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034188">
        <property type="entry name" value="FadE5-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12806">
        <property type="entry name" value="Acyl-CoA_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12418">
        <property type="entry name" value="AcylCoA_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AcylCoA_DH_N" evidence="8">
        <location>
            <begin position="3"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="162"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="286"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_C" evidence="9">
        <location>
            <begin position="471"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AKH83560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="608" mass="66420" checksum="F86CE80D441888D0" modified="2015-07-22" version="1">MGHYKSNLRDIEFNLFEVLGRGDVYGTGPFEDMDTETARSVLTEIARLAENDLAESFADGDRNPPVFDPETGTAPVPAAFRKSYETYMDAEWWRLGLPEEIGGTATPSSLIWAYAEMVLGANPAVWMYASGPAFAGVLYDEGTEEQRKAARLMVERRWGSTMVLTEPDAGSDVGAGRAKALEQPDGTWHIEGVKRFITSGEHDMSENIVHFVLARPEGAGPGTKGLSLFVVPKYDFDWETGELGERNGVYATNVEHKMGLKVSNTCELTFGDRHPAKGWLLGGKHDGIRQMFKIIEFARMMVGTKAIATLSTGYLNALEYAKERVQGPDLAQFTDKTAPRVTITHHPDVRRALMTQKAYAEGMRALVLYTASVQDTIQVREAAGEDASAQHELNDLLLPIVKGYGSEKSYEQLAQSLQTFGGSGYLQEYPIEQYIRDAKIDTLYEGTTAIQGQDYFFRKIVRNQGQALTSLAEEIKKFLAEAVGGEQLAAARDELARAAVDLEAIVGVMLTDLAATEKDVKSIYKVGLNTTRLLMASGDVVIGYLLLKGAAVAAEKLPGAAAKDVPFYQGKIAAATFFARNVLPGVGVQRSLAESTDQSLMELDEAAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4I0</accession>
    <name>A0A0F7N4I0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_08665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015641.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH82293">
        <property type="protein sequence ID" value="AKH82293"/>
        <property type="gene ID" value="AA958_08665"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_08665"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1828"/>
    <dbReference type="OrthoDB" id="2027934at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="103" mass="11418" checksum="76379A67F95B6898" modified="2015-07-22" version="1">MTEEFTTDLDEGMLEYFRDIADVMVRRIGMSRAEAVARINRAYGGMDIGPYPDLMCHELPGFRAHGLCYAGDVPYRGPDADPAGWEVREAPPLGGPEWTLPEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4K4</accession>
    <name>A0A0F7N4K4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_08720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015647.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_08720"/>
    <dbReference type="EnsemblBacteria" id="AKH82299">
        <property type="protein sequence ID" value="AKH82299"/>
        <property type="gene ID" value="AA958_08720"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_08720"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1840"/>
    <dbReference type="OrthoDB" id="1719990at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH82299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="556" mass="57597" checksum="D8154FFF5E906F7F" modified="2015-07-22" version="1">MSGSERLPALCRGLATVVVPAGVVIEGGPHRILLNGETAKEFVPRLLPLLDGVRRVDEASVQLSVAPARIRQAVRLLTDWGVVEDARTDGDLPHESAVFYSRLLATAGGYRGTGQLLDELAGARVLLTAGSDAELVRRLRADLTASGVGTVETAGDPAGNSLAVVLDPPGRPEAVGSLVRAAAAEGVPVLRIAYARDAVEAGPLFHPGDPSCTACFRKDYDALGTVLVDGGPAARGVLAGLVATEVLAVLARTTAVCSLRTLLRTSLSDYATERYLFAPDGDCDEEAGGPAVVKAGPAHAESGEPARLVDGYEWYQALPPPGLSAESRLLAPEQEQLQALLHKRPRRMSVPARELPPEPDLPPMRGGLPQSEAVPVPPARLAGLITRTAGLVGAGTGRAGPRRWAPSSGGRGSVELYVVTEADPFGLPGTVFSYDDVGHRMLSVRSDAVPLKDVLAATGLDAGDVTAAVVLVATVGRLYPRYGYFSWRLAHLDAGFAATQLAVAAQGDGVAVSFAATWPEELPHLLQLDQESECVAAVAGLAGATGAAGAAPEEDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4R1</accession>
    <name>A0A0F7N4R1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Neutral metalloproteinase</fullName>
            <ecNumber evidence="7">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AA958_09245</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Extracellular zinc metalloprotease.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase M4 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="7"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015729.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_09245"/>
    <dbReference type="EnsemblBacteria" id="AKH82383">
        <property type="protein sequence ID" value="AKH82383"/>
        <property type="gene ID" value="AA958_09245"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_09245"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1950"/>
    <dbReference type="OrthoDB" id="1465483at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023612">
        <property type="entry name" value="Peptidase_M4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001570">
        <property type="entry name" value="Peptidase_M4_C_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013856">
        <property type="entry name" value="Peptidase_M4_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01447">
        <property type="entry name" value="Peptidase_M4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02868">
        <property type="entry name" value="Peptidase_M4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00730">
        <property type="entry name" value="THERMOLYSIN"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase_M4" evidence="9">
        <location>
            <begin position="73"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M4_C" evidence="10">
        <location>
            <begin position="185"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="60"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR623612-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AKH82383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="376" mass="39508" checksum="659051569ED2CA76" modified="2015-07-22" version="1">MDASSRTPVFCTIVPPHMLDKLARTDNAALSARARRTLERDALQRTRRRITTVRRAAAAPAARRAADDAKPKRTIYDAGQTQDLPGTEVRKEGGAAVDDATVNRAYDGLGATFDLFLSGFARDSIDGAGLPLNATVHYGEDYGNAFWDGEQMVFGDGDGEVFLDFTLAVDVIGHELTHGVTQYTANLEYFGQSGALNESVSDVFGSLIKQYVKGQSAADADWLIGAELLAPGVSGEALRSMKAPGTAYDDDVLGKDPQPATMADYVDTSTDNGGVHINSGIPNHAFYLLATELGGNAWERAGRIWYDVLTGGALTATADFAAFAAATVAAAGARYGDGAERAAVLSAWSQVGVDADAEAAVPRQTPAREGAAPQAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4T3</accession>
    <name>A0A0F7N4T3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Dihydrofolate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AA958_13105</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DtxR/MntR family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016343.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_13105"/>
    <dbReference type="EnsemblBacteria" id="AKH83011">
        <property type="protein sequence ID" value="AKH83011"/>
        <property type="gene ID" value="AA958_13105"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_13105"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2757"/>
    <dbReference type="OrthoDB" id="2047422at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.60.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007167">
        <property type="entry name" value="Fe-transptr_FeoA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001367">
        <property type="entry name" value="Fe_dep_repressor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036421">
        <property type="entry name" value="Fe_dep_repressor_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038157">
        <property type="entry name" value="FeoA_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022687">
        <property type="entry name" value="HTH_DTXR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022689">
        <property type="entry name" value="Iron_dep_repressor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008988">
        <property type="entry name" value="Transcriptional_repressor_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02742">
        <property type="entry name" value="Fe_dep_repr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01325">
        <property type="entry name" value="Fe_dep_repress"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04023">
        <property type="entry name" value="FeoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00899">
        <property type="entry name" value="FeoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00529">
        <property type="entry name" value="HTH_DTXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47979">
        <property type="entry name" value="SSF47979"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50037">
        <property type="entry name" value="SSF50037"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50944">
        <property type="entry name" value="HTH_DTXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH dtxR-type" evidence="8">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH83011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="228" mass="24882" checksum="911202844D67AA87" modified="2015-07-22" version="1">MSGLIDTTEMYLRTILELEEEGVVPMRARIAERLDQSGPTVSQTVARMERDGLVRVAGDRHLELTEEGRMLATRVMRKHRLAECLLVDVIGLEWEHVHAEACRWEHVMSEAVERRVLALLKHPTESPYGNPIPGLEELGEKAEADPFLDEGMVSLSALGPDAGTVIIRRIGEPIQTDSQLMYTLRRAGVQPGAVVSVTDSAGGVLVGSGGEAAELDAEVASHVFVAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4V8</accession>
    <name>A0A0F7N4V8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_09405</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015754.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_09405"/>
    <dbReference type="EnsemblBacteria" id="AKH82409">
        <property type="protein sequence ID" value="AKH82409"/>
        <property type="gene ID" value="AA958_09405"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_09405"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1985"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH82409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="89" mass="9489" checksum="6535FBD0894F0396" modified="2015-07-22" version="1">MSDLTYVLVLPDRDAAEEVAELAVERFGLAGEPQLIRDALAGEDDAEDAQWLVVVEDAREEAAAGLEELAESYDGWLEGSATVPDDPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N556</accession>
    <name>A0A0F7N556_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_10205</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015880.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH82538">
        <property type="protein sequence ID" value="AKH82538"/>
        <property type="gene ID" value="AA958_10205"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_10205"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2149"/>
    <dbReference type="OrthoDB" id="1309950at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041669">
        <property type="entry name" value="TetR_C_15"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17918">
        <property type="entry name" value="TetR_C_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="26"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH82538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="222" mass="23412" checksum="D9250D4A5D57BFC1" modified="2015-07-22" version="1">MSNPAPAVGGHTPADRPPRRRQARGERRVQQLLDAAAAVFARSGYAAASTNAIAREAGVSPGTLYQFFPNKEAVAVELGRRYNHELQEANSEAFTPANAALPLGAMLDAALDPVIDFCAANPGFEVLLQSADAPGLVAEEHEAVHTTIVAAVEGMLTLRAPELSDTEIARTAAMSFSIFKAGLELFMTAGEAEREPYRGEIKRALFGYLAPVVGTDAIAPPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5B9</accession>
    <name>A0A0F7N5B9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA topoisomerase 1</fullName>
            <ecNumber evidence="8">5.6.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">DNA topoisomerase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">topA</name>
        <name evidence="11" type="ORF">AA958_14285</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the type IA topoisomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="8"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016523.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_14285"/>
    <dbReference type="EnsemblBacteria" id="AKH83206">
        <property type="protein sequence ID" value="AKH83206"/>
        <property type="gene ID" value="AA958_14285"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_14285"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3006"/>
    <dbReference type="OrthoDB" id="223233at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00186">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03363">
        <property type="entry name" value="TOPRIM_TopoIA_TopoI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00952">
        <property type="entry name" value="Topoisom_1_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000380">
        <property type="entry name" value="Topo_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003601">
        <property type="entry name" value="Topo_IA_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023406">
        <property type="entry name" value="Topo_IA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013497">
        <property type="entry name" value="Topo_IA_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013824">
        <property type="entry name" value="Topo_IA_cen_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013825">
        <property type="entry name" value="Topo_IA_cen_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013826">
        <property type="entry name" value="Topo_IA_cen_sub3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023405">
        <property type="entry name" value="Topo_IA_core_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003602">
        <property type="entry name" value="Topo_IA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005733">
        <property type="entry name" value="TopoI_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028612">
        <property type="entry name" value="Topoisom_1_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025589">
        <property type="entry name" value="Toprim_C_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034149">
        <property type="entry name" value="TOPRIM_TopoI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42785">
        <property type="entry name" value="PTHR42785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01131">
        <property type="entry name" value="Topoisom_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13368">
        <property type="entry name" value="Toprim_C_rpt"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00417">
        <property type="entry name" value="PRTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00437">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00436">
        <property type="entry name" value="TOP1Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56712">
        <property type="entry name" value="SSF56712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01051">
        <property type="entry name" value="topA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00396">
        <property type="entry name" value="TOPOISOMERASE_I_PROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0238">DNA-binding</keyword>
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    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0799">Topoisomerase</keyword>
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        <location>
            <begin position="8"/>
            <end position="132"/>
        </location>
    </feature>
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            <end position="186"/>
        </location>
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            <begin position="374"/>
            <end position="396"/>
        </location>
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            <begin position="463"/>
            <end position="484"/>
        </location>
    </feature>
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            <end position="790"/>
        </location>
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        <location>
            <begin position="814"/>
            <end position="957"/>
        </location>
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            <begin position="464"/>
            <end position="480"/>
        </location>
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        <location>
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            <end position="883"/>
        </location>
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    <feature type="compositionally biased region" description="Basic residues" evidence="9">
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            <begin position="884"/>
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        </location>
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        <location>
            <begin position="915"/>
            <end position="929"/>
        </location>
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            <position position="334"/>
        </location>
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        </location>
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        </location>
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        <source>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
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        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="957" mass="104396" checksum="C5FB940E69DF03A6" modified="2015-07-22" version="1">MSATSKTRRLVIVESPAKAKTIKGYLGPGYEVESSVGHIRDLPNGAAEVPAKYKGESWARLGVNVDHDFEPLYVVNSDKKQQVSKLKKLLAESDELYLATDEDREGEAIAWHLLEVLKPKVPVHRMVFHEITKDAIRQAVANPRQLNQKLVDAQETRRILDRLYGYEVSPVLWKKVMPRLSAGRVQSVATRLVVERERERIAFRSAEYWDLAGVFATGRAGDATDPRSFGAKLSAVDGRRIAQGRDFGEDGQLKSGSSADVLHLSEESARALAAALQDTAFAVRSVEAKPYRRSPSAPFRTTTLQQEASRKLGLGAKATMQVAQRLYENGFITYMRTDSTTLSETAVAAARAQVTQLYGRDYLPDRPRNYAGKVKNAQEAHEAIRPSGDRFRTPADTGLSGTEFRLYELIWMRTVASQMKDAAGQSVTVKLGGTAADGRDAEFSASGRVITFHGFMKAYVEGSDDPSADLDNRDRPLPQLAEGDRLSAEEITADGHATKPPARYTEATLVKELEEREIGRPSTYASIIGTILDRGYVFKKGTALVPSFLSFAVVGLMEKHFGRYIDYDFTARMEDDLDRIARGEAEAVPWLRRFYFGTDDVATPAGERAGADHLAGLKELVTDLGAIDAREVSTFPVGEGIVLRVGRYGPYVERGERDTEEHRRADVPDELPPDELTVELAEELLDKPSGAYELGTDPESGREIVAKDGRYGPYVTEVLPEGTPQSGKNAVKPRTASLFQSMSLDTVTLADALKLLSLPRVVGTDPESGTEITAQNGRFGPYLKKGTDSRSLQSEEQLFTVTLEEALALYAQPKQRGRAAAKPPLKELGEDPASGRPVVVKDGRFGPYVTDGETNATLRRGDEPESITPERGFELLAEKRAKGPAKKTAKKAAKKAPAKKAPAKKAAAKKTAAKKTATKTATKTAAKKATGTKTAAAKKATAKKTVSAKAAVPDEER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5D6</accession>
    <name>A0A0F7N5D6_9ACTN</name>
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        <submittedName>
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        </submittedName>
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        <name evidence="5" type="ORF">AA958_14435</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
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    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </reference>
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        <text evidence="1">Belongs to the band 7/mec-2 family. Flotillin subfamily.</text>
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    <dbReference type="EnsemblBacteria" id="AKH83231">
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    </dbReference>
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    </dbReference>
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        </location>
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        <location>
            <begin position="177"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH83231.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="370" mass="40134" checksum="1A469D516EBFFA7C" modified="2015-07-22" version="1">MFGYRVPAPDQAMLVSGGRRRRDGAPFRVVVGHGGFVLPIFRKTRFLSLAMHESEVAEYCVTRQGIPLTVRSVIAFKVGNDIESIVNAGQRFLSEQKEMSVLTGRIFAGHLRAIIGSMTVEEIVTERQKLASEVVETSKSEMGRIGLIVDSFQIQSIDDGDTGYIKAMSAPHQAAIQREAKIAEAQAAQKASEAEQESARKQAEYARETAMVRAQYKAEVSRVEAEAAQAGPLAHAHAQQDVLAAQTELAERAARLRQQELQAEVVKPAEAEAERVRVLAVAEAERMKIQAEAASSYDRVALDQQLIDQLPKIVERAAAGLQGANINVLNGADGLGELTAGLVGQGLAILDSVRTTMPQPRSPESERLND</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5L6</accession>
    <name>A0A0F7N5L6_9ACTN</name>
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    </protein>
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    </gene>
    <organism evidence="1 2">
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        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
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        </lineage>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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    </dbReference>
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH82693">
        <property type="protein sequence ID" value="AKH82693"/>
        <property type="gene ID" value="AA958_11135"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_11135"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2345"/>
    <dbReference type="OrthoDB" id="1306239at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH82693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="220" mass="23892" checksum="54D0F5656EE60BB7" modified="2015-07-22" version="1">MPAETSMSGDESVVPALAAAFDDRDAGKALAALGELLDTPAPGRRPALWHPLGCFRLDLAGDASRRRYALHCWPRGERHPAARTLTVHRHAYALESLVIDGELRNRRFGGAPGGVRGPLYRAEGGGRLSVLKRTEEVAELEVVEDRLLGPGRFYAVSAADFHESRVANAGFCVTLTRTSPKLRPGAHALGGFTTPPVLLYRRTPVTETLLTRLMDHVGRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5N4</accession>
    <name>A0A0F7N5N4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_07710</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015487.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_07710"/>
    <dbReference type="EnsemblBacteria" id="AKH82137">
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        <property type="gene ID" value="AA958_07710"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_07710"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1621"/>
    <dbReference type="OrthoDB" id="792835at2"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519160" evidence="2">
        <location>
            <begin position="21"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="374"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH82137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="415" mass="43174" checksum="95F18581B3CB636B" modified="2015-07-22" version="1">MVAVTATSPPRLPASPGRHAAPPTAAPPTAAPPAAAPGRPVGRAGFTLTADGTYGACLAADADGNWFPERWTLHGPEAYTVPLPCAQPEEPGTTVLPLADGRVLVRRLVGGADHTFSLLHPSGPDTTEQTLGSVTAPRLALVPPAPESAEVYALAPPEPGGETTAVWRVYGGGFAGAGTAHPERVGELPGRCAGRGWLDRTGRALAVDQERDGRTKAVTVGLHGGVEVSPLLMLTEESNDRLLLADPDSGLLLLRSDAPGRDRLGWGVLGSGRPVRFPDALCPRDTAVTPFAVQPGQVLTPEHCGVALRLEGPGGCRLGVWRPAARRLVQLPPLPGWITGSGLWTQWGELRLPYATPAHPCGLARLAIPDPSAAELLNAPPLSDPPPDRAPDETGEPPPEEDAPTRPVPLRHAPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5P8</accession>
    <name>A0A0F7N5P8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cobalt ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_07785</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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            <end position="60"/>
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            <end position="367"/>
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    </evidence>
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</entry>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
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    </dbReference>
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            <end position="213"/>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
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            <dbReference type="EMBL" id="AKH82162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="220" mass="23597" checksum="A01D7675A9AD4EF0" modified="2015-07-22" version="1">MSGISQRPFARLKVYARHLAAPLAAAALLLTAAPSAQAEPPAPPGADTALGYLAEITTAPEGSSDGYDRDLFPHWSTQSGACNTREVVLERDGDNVEQDASCAAVGGSWYSPYDGATWTQSSDVDIDHMVPLAEAWRSGASAWSTGEREQFANDLEIAQLLAVTDNVNQSKGDKDPAEWMPPSTGYHCTYASMWVWVKHTYDLTADDAEKAKLESVLSGC</sequence>
</entry>
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                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="149" mass="16478" checksum="B8E03C88F6DA5200" modified="2015-07-22" version="1">MHTDNAHPYLRAASAGIRHHTRALTRPGTEPATPADRPHLDVLHAHLTAVHQLLDHLAETTRPRHPAAGRHLAATHTRLWQAAAELHDAFHLLPTTTADDAEARACHPERLPEGPPVLTICQRHLAAGHSIRRKTTPTDHRPHTTTCTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5T7</accession>
    <name>A0A0F7N5T7_9ACTN</name>
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    </gene>
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        <lineage>
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            <authorList>
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
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        <text evidence="1">Belongs to the peptidase C40 family.</text>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <end position="38"/>
        </location>
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            <end position="376"/>
        </location>
    </feature>
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        <location>
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            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="201"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH83935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="376" mass="40133" checksum="AA99A860D1C9710A" modified="2015-07-22" version="1">MKALAAGLGVVFLSPFLLAGTGMMLASSSNAVRTAASADSCLTDADTAEITDQVARILDGASGKDILIEGLDLPEEQVPHAATIVATGRPLNVPAKGQVIALATAMQESRLRNLTYGDRDSLGLFQQRPSQGWGTAEQIRDPVYAAEQFYQRLLTVDGWQQMTITQAAQAVQKSAYPDAYAQWENLATALQAAITATFPTTGDDEQTAEADSSVGGTGCARGPDGSGFGPIPEGSIPNGYRIPRDADPKARAAMAWAMRQLGTLYQWGGSCTDAHGPDPMGRCDCSSLMQQAYRHAGITLTRTTYTQINEGKPVPHDQLRQFQPGDLIFSRGTAARPEHVGMYMGQGLVIEAPRTGKPVRITPLAEWTVLAVRRVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5Y0</accession>
    <name>A0A0F7N5Y0_9ACTN</name>
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        <submittedName>
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        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="2 3">
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        <lineage>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_15845"/>
    <dbReference type="EnsemblBacteria" id="AKH83436">
        <property type="protein sequence ID" value="AKH83436"/>
        <property type="gene ID" value="AA958_15845"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_15845"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3338"/>
    <dbReference type="OrthoDB" id="1196738at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="33"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="298" mass="31509" checksum="6BCDD115A4DC92D2" modified="2015-07-22" version="1">MNGTAEVRPEAERLVRVGEVDICTQAFGAAADPPILLIGGAEASMDWWEDGFCSRLAAAGRYVVRFDTRDTGRSTTFPVGAPTYGGEDLIADVIGLLDALGLRSAHLVGVSMGGGMAQVIAARYPGRVDSLTLIATSPAAPGGPDRPELPPMSDELARKFAEPQPGPDWSDRESVLAYFLAGEHTFAGAIPVDEERVRRVAGRAFDRSPAPAAAANHWLLDDGKEQDALSLGDITAPTLVLHGTDDPLFPYAHGEALAREIPGARLVPLRGMGHQMPPPELWDAVIAELVPHTAAAAR</sequence>
</entry>
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    <accession>A0A0F7N5Z0</accession>
    <name>A0A0F7N5Z0_9ACTN</name>
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        <name evidence="4" type="ORF">AA958_11905</name>
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        <name type="scientific">Streptomyces sp. CNQ-509</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
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        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
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    <dbReference type="EnsemblBacteria" id="AKH82819">
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        <property type="gene ID" value="AA958_11905"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        </location>
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            <end position="109"/>
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        <location>
            <position position="18"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
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        <location>
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        </location>
        <ligand>
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        </ligand>
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        <location>
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        <ligand>
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        </ligand>
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</entry>
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                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">CNQ-509</strain>
        </source>
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        </source>
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        </source>
    </evidence>
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</entry>
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                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
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        </source>
    </evidence>
    <sequence length="236" mass="25991" checksum="A662C4D494C010FA" modified="2015-07-22" version="1">MRGKDEENLTVVHVVRHGEVHNPDGVLYGRNPGYHLSDLGRRMAERVGEHLSARDVRYVVASPLERAQETAAPVAKAHGLEVATDDRLIEAANVFEGKAFGVGDGALRKPANWKYFTNPFRPSWGEPYIEQVVRMTGALQSAREAARGHEAVCVSHQLPIWILRSFAEGRRLWHDPRSRQCTLASLTTFTFDGDDIVSVGYSEPARDLVPPHLLAGAQRKFGRGAIRGAAANAPRA</sequence>
</entry>
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    <accession>A0A0F7N6F7</accession>
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                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
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        <property type="gene ID" value="AA958_20795"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_20795"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4386"/>
    <dbReference type="OrthoDB" id="1806532at2"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
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        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
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            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="domain" description="YccF" evidence="2">
        <location>
            <begin position="7"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="YccF" evidence="2">
        <location>
            <begin position="71"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH84225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="135" mass="14733" checksum="A20538C7AAC73063" modified="2015-07-22" version="1">MKPLNLLLNVLWLIFCGIWMAIAYTVAALVCFILIITIPFGIASLRIAGYVLWPFGRTTVERPGAGAPSVVGNVIWVIFAGWWLALGHLLTSIPLFLSIIGIPFGWANLKLIPVSLMPLGRAIVSTDEPFGYAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6H5</accession>
    <name>A0A0F7N6H5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="6 7">
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        <lineage>
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    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the thioredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016279.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_12725"/>
    <dbReference type="EnsemblBacteria" id="AKH82944">
        <property type="protein sequence ID" value="AKH82944"/>
        <property type="gene ID" value="AA958_12725"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_12725"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2674"/>
    <dbReference type="OrthoDB" id="1630944at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000077">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 4" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="5">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="4">
        <location>
            <begin position="44"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000077-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH82944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="119" mass="12718" checksum="91BF22336C85F2CF" modified="2015-07-22" version="1">MTTTPGTTPQTTTQGVPYVTDETFAEEVLRADVPVLVQFTAQWCPSCKQLTPVIGALAAELGDRVRAVRLDVDHNPLTTVAHGVLAVPTLLVFQGGEPVRSVVGARSRARLLRDLDGVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6P3</accession>
    <name>A0A0F7N6P3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5 7">50S ribosomal protein L15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rplO</name>
        <name evidence="10" type="ORF">AA958_21270</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uL15 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018834829.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_21270"/>
    <dbReference type="EnsemblBacteria" id="AKH84305">
        <property type="protein sequence ID" value="AKH84305"/>
        <property type="gene ID" value="AA958_21270"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_21270"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4479"/>
    <dbReference type="OrthoDB" id="1874945at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01341">
        <property type="entry name" value="Ribosomal_L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="L18e/L15P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030878">
        <property type="entry name" value="Ribosomal_L15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005749">
        <property type="entry name" value="Ribosomal_L15_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001196">
        <property type="entry name" value="Ribosomal_L15_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_L18e/L15P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12934">
        <property type="entry name" value="PTHR12934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00828">
        <property type="entry name" value="Ribosomal_L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="SSF52080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01071">
        <property type="entry name" value="rplO_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00475">
        <property type="entry name" value="RIBOSOMAL_L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L18e/L15P" evidence="9">
        <location>
            <begin position="37"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AKH84305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="156" mass="16620" checksum="AA8298228BE67B21" modified="2015-07-22" version="1">MAVQDAAEQKPLKIHNLRPAPGAKKPKTRVGRGEASKGKTAGRGTKGTKARYQVPERFEGGQMPLHMRLPKLKGFKNPARKVYQVVNLDKLAELYPEGGEVTVADLVAKGAVRKNELVKVLGNGDVSVALQVAVDKVSGSAREKITAAGGSVTERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6U9</accession>
    <name>A0A0F7N6U9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_10260</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015889.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH82547">
        <property type="protein sequence ID" value="AKH82547"/>
        <property type="gene ID" value="AA958_10260"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_10260"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2162"/>
    <dbReference type="OrthoDB" id="1704351at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519266" evidence="2">
        <location>
            <begin position="24"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH82547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="219" mass="23344" checksum="43B42AE6818742E1" modified="2015-07-22" version="1">MKLCAPASAVALTAAVTLLTACGSSDDKPDRITGAKETAAESEESPSASPSPAADDGADAPEFDFPDDVKVEVESEPTGDAAEDAILRDHGYAVQSIRLGYAKQDPRLDVLERYLGGDALLGWRAGIDEFVQDGKTVSGTVRYYDREVTSRKGDAASVVYCEDQTNSYAKIADSGKVLKTEPSADDFIRHVSTMRKTADGRWQMVHESDEQGAAQCGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N701</accession>
    <name>A0A0F7N701_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sugar ABC transporter ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_14000</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016492.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_14000"/>
    <dbReference type="EnsemblBacteria" id="AKH83164">
        <property type="protein sequence ID" value="AKH83164"/>
        <property type="gene ID" value="AA958_14000"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_14000"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2946"/>
    <dbReference type="OrthoDB" id="551294at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH83164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="497" mass="52835" checksum="2C9BCB28EC4736AF" modified="2015-07-22" version="1">MLTMQDVSKSFLGVRVLHGVSLDLEPGEVHALVGENGAGKSTLMKVLAGEYAPDEGTITLDGTVHAFSHPVQAQAAGIGLIHQEFALLPHRTVAENVFLGREPVRRGLVDRRAMERRTAELLAELDETGIAPHTQVKDLSVARQQTVEIVKALAASDVRVLVMDEPTAPLADHEVELLYALIRRLAARGIGILYISHRLREVFDLSRRITVLKDGRKVATLTTAETTPDDVVRAMVGRELGSYYPPRARAGEIGEPLLTTAGAGNERLAGIDLTLRAGEVTGVAGLQGSGRTSLVRALFGAAPFTRGSMTVAGRPLRPGSPRQAIRGGVALVTEDRKGEGLVLHQSVRDNALLVTRAVHGGGVQAGEVSGLLDRVNLRSRGHDQEVQYLSGGNQQKVVIAKWLAARPRVLLFDEPTRGVDVGAKAAIHTLVRELARDGMAVLIVSSELPELIGMSDRILVMADGTFAGELPAGAGEEDIMRLATRDAAGTAPEGSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N726</accession>
    <name>A0A0F7N726_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_21750</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017647.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_21750"/>
    <dbReference type="EnsemblBacteria" id="AKH84385">
        <property type="protein sequence ID" value="AKH84385"/>
        <property type="gene ID" value="AA958_21750"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_21750"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4581"/>
    <dbReference type="OrthoDB" id="1908825at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021224">
        <property type="entry name" value="DUF2690"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10901">
        <property type="entry name" value="DUF2690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="22"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH84385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="485" mass="49256" checksum="E95C9F457F7CB52E" modified="2015-07-22" version="1">MARWKELPEELDPQIRDFAAHMRRLVDRSGLTVSEVADRTGYSRSSWERYLNGRLMPSRESVVAFAEVTGARDDQLMTEWSAADRAWSRAELRNRSALRALRAAEPGPDDLQDPEPGRQGRGLRGVLGRGRGRGEETPGAGETARLGGAGGAAQGAERPVHPDATERSAVRPGPPPPPERRATRAAGKGDAGAGTGAGERTAAAAGAAAAAGAGRGAEAGTDSGADAGTDAGGEAGSSAVDPAARDADETTKLRALSRPTPPPAPEPAGETAPTRPISTAPAPAPPAAAPPRKNWPLRRVLLAGLVTLLLTGGGAGVLYVGHGLISDPGVEEQQKPRGGPPPGSGPTGKTSGPGSGSGSPSGSAELPEGVECRGDGCTGKDADEMGCGGEFARTTTETTIGDMVLEIRYSEPCQAAWARITAAEPGSTVTALAEVPGEEPVREDSSAGTSEGYTAMVVAEELDTVRACAELPDGTAACTKGTLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N732</accession>
    <name>A0A0F7N732_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_21820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH84395">
        <property type="protein sequence ID" value="AKH84395"/>
        <property type="gene ID" value="AA958_21820"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_21820"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4595"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH84395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="153" mass="16569" checksum="DC51FB4ED9A91BCA" modified="2015-07-22" version="1">MPIAPSTAPAAVVAVIETVSETSTVPPSPKRMRASLPLPRNRFSETSARSHTARRASRRVLIQLTPVNRSAASEIRPTVPAFAKRPPRSSRSEMPGTCSVIHFSTSLRRLSLRTAAETAAALVSRGKRATKLLNVTAPASRLQCRAWTYAKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7M0</accession>
    <name>A0A0F7N7M0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NUDIX hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_15390</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016676.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH83364">
        <property type="protein sequence ID" value="AKH83364"/>
        <property type="gene ID" value="AA958_15390"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_15390"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3237"/>
    <dbReference type="OrthoDB" id="1308416at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="4">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH83364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="135" mass="14481" checksum="3DC529A9F02376F0" modified="2015-07-22" version="1">MSVAGVIVNDEGRALLIQRRDNGQWEPPGGVLEPGETIPEALQREVLEETGIKIALPATLTGVYKNMTGLIVSLVFRCNATDGTPTTGDETYALRWATRAEVNELADEAYAIRVLDALDAASPPAVRAHDGVRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7Q2</accession>
    <name>A0A0F7N7Q2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Gluconolaconase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_19830</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017346.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_19830"/>
    <dbReference type="EnsemblBacteria" id="AKH84056">
        <property type="protein sequence ID" value="AKH84056"/>
        <property type="gene ID" value="AA958_19830"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_19830"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4179"/>
    <dbReference type="OrthoDB" id="852341at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013658">
        <property type="entry name" value="SGL"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08450">
        <property type="entry name" value="SGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGL" evidence="2">
        <location>
            <begin position="13"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH84056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="278" mass="29936" checksum="84B1265C83C7FAB1" modified="2015-07-22" version="1">MSAPEVLMEGVVFGESPRWHNEQLWFSDWGANQVIALDADGRHEVVVTVPSFPMCIDFLPDGRLLVVDSAQRRLLRHEPDGSLVQHADLSKVSEKPWNDIVVDDRGNAYVNTIGFDFPGGEFAPGLIVLVTPEGNVDQIADDLAFPNGMAISPDGATLIVAESYANRLTAYDIGSHGGLGNRRVWAETPDDHPDGICMDVEGAVWYADVGNRHCVRVREGGEVLATVDLDRGAFACALSRGDDPRLFVVGQTWGGPESRQPSGRVVAFPAPAPGAGKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7T4</accession>
    <name>A0A0F7N7T4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative membrane protein insertion efficiency factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_16195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Could be involved in insertion of integral membrane proteins into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0161 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83493.1"/>
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    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00278">
        <property type="entry name" value="TIGR00278"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="94" mass="10805" checksum="394A52DFAB4032EC" modified="2015-07-22" version="1">MKYPLLWLIKLYQWTISPLLGPVCKYYPSCSHYGYEAIRLHGAVKGTGLTAWRILRCNPWSLGGVDHVPPRKHPVWHQRLRSRLGKTQPKAQGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7X6</accession>
    <name>A0A0F7N7X6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_16445</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_16445"/>
    <dbReference type="EnsemblBacteria" id="AKH83533">
        <property type="protein sequence ID" value="AKH83533"/>
        <property type="gene ID" value="AA958_16445"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_16445"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3461"/>
    <dbReference type="OrthoDB" id="1437290at2"/>
    <dbReference type="Proteomes" id="UP000034283">
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    </dbReference>
    <dbReference type="GO" id="GO:0003677">
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041490">
        <property type="entry name" value="KstR2_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17932">
        <property type="entry name" value="TetR_C_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="17"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="4">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH83533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="204" mass="22406" checksum="552C718BFAFCBE17" modified="2015-07-22" version="1">MAESRRTGAQSGAKRDTYTPETLLAVAVEVFLERGYDGTSMEHLSRAAGISKSSIYHHVRGKEELLHRAVSRALDGLFGVLDEPAARTGRAVDRLEAVARGTTAVLMAELPYVTLLLRVRGNTETERWAMERRREFDARVAALLKEAVADGDLRADVDVRLATRLLFGMINSIAEWYRPRAGNAHDDAEVTAAVVTLAFAGLRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7Z1</accession>
    <name>A0A0F7N7Z1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_16420</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_16420"/>
    <dbReference type="EnsemblBacteria" id="AKH83529">
        <property type="protein sequence ID" value="AKH83529"/>
        <property type="gene ID" value="AA958_16420"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_16420"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3456"/>
    <dbReference type="OrthoDB" id="1387983at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011020">
        <property type="entry name" value="HTTM"/>
    </dbReference>
    <dbReference type="SMART" id="SM00752">
        <property type="entry name" value="HTTM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="313"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="346"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="370"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="HTTM" evidence="7">
        <location>
            <begin position="43"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="403"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH83529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="441" mass="48420" checksum="7C9EF2F9812F185F" modified="2015-07-22" version="1">MGGERPVTSAPHTPPTPPKVPSASELRRRFEDALTRGLGHVTTRALGPYQTAVVRIGFAFTWLCFLLRELPHRHELYGPDGPWSYDLGKRLISQTDAFTLLMWSRSEFWFEIVYLLAIAASVMLLLGWRTRTASVLFMIGVLSLQNRSIFMGDGGDNVIHLMATYLVITRCGQVWSLDARRARRQAALGTAAPARDRVGTVLWAVTGAALAAATVLGHLTWGWALIFWGLWVAHAVWWAVRRARSAEPRTVCDVLANLAHNAGLLVIMAQVCFIYATAGWYKVQGTRWQDGTAVYYPLKLDYFTPWPGLADMMAGNGAVIMLLGYGTVIVQVAFPFTLFNRRLKNVLLTVMIIDHASIAVIMGLPFFSAAMISADLVFLPTIFLVWTGAKVTGLKNLLLGRVPGTAPPDKHPPQRPEAERPDPGIPAQAGSPEAHADAGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N811</accession>
    <name>A0A0F7N811_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NADPH-dependent FMN reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_16670</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016878.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_16670"/>
    <dbReference type="EnsemblBacteria" id="AKH83573">
        <property type="protein sequence ID" value="AKH83573"/>
        <property type="gene ID" value="AA958_16670"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_16670"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3508"/>
    <dbReference type="OrthoDB" id="1818437at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN_red" evidence="2">
        <location>
            <begin position="31"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH83573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="216" mass="23079" checksum="92E95EDF2FE5AC9B" modified="2015-07-22" version="1">MRNGESGVRETPGAAAASGPPGAAGAGALLRIACILGGQEEPDCRPPAVAHWLDELAGARGDMTLRVLDLADYDLPLRYPAHPTEQMASFTAELASAEGFVVVTPECNRSFPAQLKHAIDTGYDEWHAKPVGFVSYGFGCDGVRAVEHLRSVFTELHTVTVRDSVGIDLRFTDEKFPAGGSLYSDGLVRAAGALLDQLTWWGLALREARATRPYVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N834</accession>
    <name>A0A0F7N834_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cyclic dehypoxanthine futalosine synthase</fullName>
            <shortName evidence="6">Cyclic DHFL synthase</shortName>
            <ecNumber evidence="6">1.21.98.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Dehypoxanthine futalosine cyclase</fullName>
            <shortName evidence="6">DHFL cyclase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Menaquinone biosynthetic enzyme MqnC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">mqnC</name>
        <name evidence="8" type="ORF">AA958_20560</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>dehypoxanthine futalosine + S-adenosyl-L-methionine = 5'-deoxyadenosine + cyclic dehypoxanthinylfutalosinate + H(+) + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:33083"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58864"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64270"/>
            <dbReference type="EC" id="1.21.98.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="6">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Quinol/quinone metabolism; menaquinone biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the radical SAM superfamily. MqnC family.</text>
    </comment>
    <dbReference type="EC" id="1.21.98.1" evidence="6"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017468.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_20560"/>
    <dbReference type="EnsemblBacteria" id="AKH84181">
        <property type="protein sequence ID" value="AKH84181"/>
        <property type="gene ID" value="AA958_20560"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_20560"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4337"/>
    <dbReference type="OrthoDB" id="419725at2"/>
    <dbReference type="UniPathway" id="UPA00079"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046992">
        <property type="term" value="F:oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00992">
        <property type="entry name" value="MqnC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045567">
        <property type="entry name" value="CofH/MnqC-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022431">
        <property type="entry name" value="Cyclic_DHFL_synthase_mqnC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034405">
        <property type="entry name" value="F420"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020050">
        <property type="entry name" value="FO_synthase_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43076">
        <property type="entry name" value="PTHR43076"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19288">
        <property type="entry name" value="CofH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00343">
        <property type="entry name" value="aminofutalosine_synthase_(mqnE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03699">
        <property type="entry name" value="menaquin_MqnC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00423">
        <property type="entry name" value="TIGR00423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="7">
        <location>
            <begin position="54"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH84181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="398" mass="43707" checksum="8373385BB70B97AB" modified="2015-07-22" version="1">MTTDLQAVLDRAAAGGRVTPGEALDLYRSAPLHALGAAADAVRRRRYAGTEHIATYIIERNINYTNVCVTACKFCAFYAPPTAKDKGWIRGLDDILRRCEETVQLGGTQIMFQGGHHPDFGVEYYEEHFSAIKKAFPQLVIHSLGASEVEHMARISGTTAEDAIRRIHAAGLDSFAGAGAELLPARPRQAIAPLKESGERWLEIMESAHGLGVESTSTMLMGTGETNAERIEHLRMIRDVQDRTGGFRAFIPYTYQPENNKLKGRTQATTLEYLRMIAIARIFLDNVAHIQGSWLTTGKDVGQLTLHYGADDLGSVMLEENVVSSAGARHRSNLREIIEMIRGADRVPAQRATTYEHLVVHDDPADDPVDDRVVSHLSSTALDGGTAHPELTLVEADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N869</accession>
    <name>A0A0F7N869_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_17130</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016952.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_17130"/>
    <dbReference type="EnsemblBacteria" id="AKH83648">
        <property type="protein sequence ID" value="AKH83648"/>
        <property type="gene ID" value="AA958_17130"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_17130"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3602"/>
    <dbReference type="OrthoDB" id="1951939at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002810">
        <property type="entry name" value="NfeD-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01957">
        <property type="entry name" value="NfeD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="32"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="NfeD" evidence="3">
        <location>
            <begin position="54"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH83648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="145" mass="14836" checksum="963C5BD334D0371A" modified="2015-07-22" version="1">MPWIVWLLAAAALGAAEFFTMTLVFGLLAGAALVAAVVAGVGVGALGQFVALGAAAAAGLVVVRPIAKKHMAQTPLSREGSDALLGKRAEVVQEVTATRGLIKLSGEEWSARAFDESSVIPVGALVEVMEIEGATAVVYPRELLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8G4</accession>
    <name>A0A0F7N8G4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Holo-[acyl-carrier-protein] synthase</fullName>
            <shortName evidence="8">Holo-ACP synthase</shortName>
            <ecNumber evidence="8">2.7.8.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">4'-phosphopantetheinyl transferase AcpS</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">acpS</name>
        <name evidence="10" type="ORF">AA958_21380</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>apo-[ACP] + CoA = adenosine 3',5'-bisphosphate + H(+) + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:12068"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9690"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="EC" id="2.7.8.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the P-Pant transferase superfamily. AcpS family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.7" evidence="8"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017589.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_21380"/>
    <dbReference type="EnsemblBacteria" id="AKH84326">
        <property type="protein sequence ID" value="AKH84326"/>
        <property type="gene ID" value="AA958_21380"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_21380"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4501"/>
    <dbReference type="OrthoDB" id="1893660at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00101">
        <property type="entry name" value="AcpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008278">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002582">
        <property type="entry name" value="ACPS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004568">
        <property type="entry name" value="Ppantetheine-prot_Trfase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01648">
        <property type="entry name" value="ACPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56214">
        <property type="entry name" value="SSF56214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00516">
        <property type="entry name" value="acpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00556">
        <property type="entry name" value="pantethn_trn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="4 8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="1 8" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACPS" evidence="9">
        <location>
            <begin position="6"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AKH84326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="124" mass="12870" checksum="AB8D1807CA11D115" modified="2015-07-22" version="1">MSGIVGVGIDVAEVGRFGAALERTPELADRLFLPAEQVLPDGGRRGVASLAVRFAAKEALAKALGAPSGLHWHDAEVCVYDNGRPHLRVRGTVAARAAELGVRTWHVSLSHDAGVASAVVIAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8I9</accession>
    <name>A0A0F7N8I9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CarD family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_13465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018836077.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_13465"/>
    <dbReference type="EnsemblBacteria" id="AKH83072">
        <property type="protein sequence ID" value="AKH83072"/>
        <property type="gene ID" value="AA958_13465"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_13465"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2831"/>
    <dbReference type="OrthoDB" id="1942592at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036101">
        <property type="entry name" value="CarD-like/TRCF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003711">
        <property type="entry name" value="CarD-like/TRCF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042215">
        <property type="entry name" value="CarD-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02559">
        <property type="entry name" value="CarD_CdnL_TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01058">
        <property type="entry name" value="CarD_TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141259">
        <property type="entry name" value="SSF141259"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CarD_TRCF" evidence="1">
        <location>
            <begin position="2"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="160" mass="17862" checksum="185522ECC3603CBA" modified="2015-07-22" version="1">MTFKVGDTVVYPHHGAALIEAIETRQIKGVDKTYLVLKVAQGDLTVRVPADNAEFVGVRDVVGQEGLERVFEVLRAPYAEEPTNWSRRYKANLEKLASGDVIKVAEVVRDLWRRERERGLSAGEKRMLAKARQILVSELALCESTNEDKAEALLDEVLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N924</accession>
    <name>A0A0F7N924_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_22600</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017784.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_22600"/>
    <dbReference type="EnsemblBacteria" id="AKH84526">
        <property type="protein sequence ID" value="AKH84526"/>
        <property type="gene ID" value="AA958_22600"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_22600"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4755"/>
    <dbReference type="OrthoDB" id="944044at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002549">
        <property type="entry name" value="AI-2E-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21716">
        <property type="entry name" value="PTHR21716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01594">
        <property type="entry name" value="AI-2E_transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="95"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="135"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="280"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="308"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="334"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="378"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="22"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="422"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH84526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="472" mass="49237" checksum="4C178A71EFE0D5E5" modified="2015-07-22" version="1">MSKMTDWLGGVGERASRMAERRRAAAAAAGAGKPAAGEAAVEDAPQDAPQDVVAEPAAAARPPGPPPRPAPASVVPWGVRVAAEVGWRLLVLAGLIYVLMQIISVVSLVVIAFAVGLLVTALLQPTVARLRRWGFSQGLATATTFVGGFVAIGLIGWFVVWQIMENIDDLTDRIQQGIDDAQEWLIDGPFHVQEKQINNIGNEISDWLGENSSEVTSAGLEGVSYVLEFFSGAAIAAFVTLFLLYDGERIWRWCLNFVPTDARDAVAGAGPKVWATLTGYVRGTVLVAFIDAVFIGIGIFILDVPMAVPLAVLIFLFAFVPLVGALVSGALAVVVAFVTNGLVTALLVLGVVLLVQQIEGHVLQPFILGRMVRVHPLAVVLSVAIGTLVAGIPGAVVAVPLIAVLNTAVGYLKAYHREHAADPGPPPYGSTVLEISPATPTDAPAPGSDAETAEAAAATRQGPEAKSGDPKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9Z0</accession>
    <name>A0A0F7N9Z0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">30S ribosomal protein S14 type Z</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">rpsN</name>
        <name evidence="5" type="synonym">rpsZ</name>
        <name evidence="6" type="ORF">AA958_21240</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018834835.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_21240"/>
    <dbReference type="EnsemblBacteria" id="AKH84299">
        <property type="protein sequence ID" value="AKH84299"/>
        <property type="gene ID" value="AA958_21240"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_21240"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4473"/>
    <dbReference type="OrthoDB" id="2032609at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01364_B">
        <property type="entry name" value="Ribosomal_S14_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001209">
        <property type="entry name" value="Ribosomal_S14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043140">
        <property type="entry name" value="Ribosomal_S14/S29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018271">
        <property type="entry name" value="Ribosomal_S14_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023053">
        <property type="entry name" value="Ribosomal_S14_Z"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19836">
        <property type="entry name" value="PTHR19836"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00253">
        <property type="entry name" value="Ribosomal_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00527">
        <property type="entry name" value="RIBOSOMAL_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="2 5" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH84299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="61" mass="7006" checksum="BCAD0DA1566BA8B8" modified="2015-07-22" version="1">MAKKALIAKAGRKPKFKVRGYTRCQRCGRPHSVYRKFGLCRVCLREMAHRGELPGVTKSSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAF5</accession>
    <name>A0A0F7NAF5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNA polymerase subunit sigma-70</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_21985</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH84419">
        <property type="protein sequence ID" value="AKH84419"/>
        <property type="gene ID" value="AA958_21985"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_21985"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4630"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="41"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="7">
        <location>
            <begin position="138"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="206"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH84419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="235" mass="25553" checksum="EC7E77CADDE583FC" modified="2015-07-22" version="1">MGDYDRPAAARAAPGHKGADEDLQPLVHRAQNGDETAFTALYRRLQPVLLAYLRGVVGDDAEDVAADAWLVIARDLGKFRGDGPSFRGWTVTVARRRALDLLRRERRRPQGVLLDEGVHDLPAERAAEEHALESLGTRQVLRLISTLPRDQAEAVLLRTVAGMRATDAGEVLGKRPGAVRTAAHRGLRQLAELVTPAARRERSLERAAFAADESGPPAAEREEGTEEQLKLGLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAG2</accession>
    <name>A0A0F7NAG2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_25665</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018296.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH85046">
        <property type="protein sequence ID" value="AKH85046"/>
        <property type="gene ID" value="AA958_25665"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_25665"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5410"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH85046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="64" mass="6808" checksum="0EF0BF854CE06BF4" modified="2015-07-22" version="1">MIFRTIANPRRTTLAHLDDAGDLLLPEPPEAVAARIAAAAPAVQPPERTANPRRTVLEEIPSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAL2</accession>
    <name>A0A0F7NAL2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Probable dual-specificity RNA methyltransferase RlmN</fullName>
            <ecNumber evidence="12">2.1.1.192</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">23S rRNA (adenine(2503)-C(2))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">23S rRNA m2A2503 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Ribosomal RNA large subunit methyltransferase N</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">tRNA (adenine(37)-C(2))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">tRNA m2A37 methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">rlmN</name>
        <name evidence="15" type="ORF">AA958_26025</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>adenosine(2503) in 23S rRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2-methyladenosine(2503) in 23S rRNA + 5'-deoxyadenosine + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42916"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10152"/>
            <dbReference type="Rhea" id="RHEA-COMP:10282"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74497"/>
            <dbReference type="EC" id="2.1.1.192"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>adenosine(37) in tRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2-methyladenosine(37) in tRNA + 5'-deoxyadenosine + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:43332"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10485"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74497"/>
            <dbReference type="EC" id="2.1.1.192"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="12">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="12">Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the radical SAM superfamily. RlmN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.192" evidence="12"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018347.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_26025"/>
    <dbReference type="EnsemblBacteria" id="AKH85106">
        <property type="protein sequence ID" value="AKH85106"/>
        <property type="gene ID" value="AA958_26025"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_26025"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5480"/>
    <dbReference type="OrthoDB" id="1111428at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070040">
        <property type="term" value="F:rRNA (adenine-C2-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002935">
        <property type="term" value="F:tRNA (adenine-C2-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01849">
        <property type="entry name" value="RNA_methyltr_RlmN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040072">
        <property type="entry name" value="Methyltransferase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027492">
        <property type="entry name" value="RNA_MTrfase_RlmN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004383">
        <property type="entry name" value="rRNA_lsu_MTrfase_RlmN/Cfr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30544">
        <property type="entry name" value="PTHR30544"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006004">
        <property type="entry name" value="CHP00048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00275">
        <property type="entry name" value="adenosine_C2_methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00048">
        <property type="entry name" value="rRNA_mod_RlmN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 12" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9 12" id="KW-0408">Iron</keyword>
    <keyword evidence="10 12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 12 15" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="7 12" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 12 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Radical SAM core" evidence="14">
        <location>
            <begin position="115"/>
            <end position="355"/>
        </location>
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        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="12">
        <location>
            <begin position="184"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="12">
        <location>
            <begin position="241"/>
            <end position="243"/>
        </location>
    </feature>
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        <location>
            <position position="109"/>
        </location>
    </feature>
    <feature type="active site" description="S-methylcysteine intermediate" evidence="12">
        <location>
            <position position="360"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
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        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
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        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
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        <location>
            <position position="218"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:59789"/>
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        <location>
            <position position="317"/>
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            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="HAMAP-Rule" id="MF_01849"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AKH85106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="372" mass="40465" checksum="8D8365289FDE4222" modified="2015-07-22" version="1">MPKPGELTFAVPRGAKKPPRHLADLTPAERRDAVAGLGEKPFRAAQLSRHYFARYATDPAGWTDVPAASRAKLAEGLLPELMTVVRHLSCDGDTTRKTLWRLFDGTLVESVLMRYPDRVTMCISSQAGCGMNCPFCATGQAGLTRNLSTAEIVHQIVDGMRALRDGEVPGGPARLSNIVFMGMGEPLANYNRVLSAIRRLTDPEPDGLGLSQRGITVSTVGLVPAMHRFADEGLKCRLAVSLHAPDDELRDTLVPVNTRWQVREVLDAAWEYAARSGRRVSIEYALIKDINDQAWRADLLGRLLKGRRAHVNLIPLNPTPGSQWTASRPEDERAFVAALEAHGVPVTVRDTRGQEIEGACGQLAASAADTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
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        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
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            <begin position="805"/>
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</entry>
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    </gene>
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        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 13 family.</text>
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AKH85246">
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    </dbReference>
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        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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            <begin position="14"/>
            <end position="406"/>
        </location>
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            <begin position="396"/>
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        </location>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AKH85246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="551" mass="61115" checksum="27380071327AE499" modified="2015-07-22" version="1">MSDTSWWRGAAIYQVYVRSFADGDGDGTGDLAGVRARLPYLAELGVDAIWFTPWYVSPMADGGYDVADYRAIDPAFGTLDEAEKLIAEARALGIRTIVDVVPNHVSDAHPWFRAALAAGPGSPERELFHFRRGRGPGGELPPNNWPSQFNGECWTRHADGDWYLHLFSERQPDLNWAHPAVRREHEDVLRFWFERGAAGVRIDSAALLAKDPELPDWDEDDPRGEPSPYVDRDELHDIYRSWRAIADEYDGVLIGELWVPEPERFSRYLRPDELHTAFNFDFLARPWDAAELRASIDTTLEYHAPVGAPATWVLCNHDVTRTVTRYGRDDADPGTGFDFAAKRFGTPTDPVRGTRRARAAALLSLALPGSVYLYQGEELGLPEAEIPRDRIVDPMHFRSGGRDPGRDGCRVPLPWRPGGPSYGFSDPADAGDDGTSREGDGAAPAGPWLPQPAGWGTYAVERQQDDPRSMLRLYHDALRLRRGEPGLGDGPMRWLEAPAGVLSFARSDAFVCVVNLAAEPVPLPAHRDVLIGSAPLDGGRLPRDTAVWLRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAX6</accession>
    <name>A0A0F7NAX6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ParB domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">AA958_29275</name>
    </gene>
    <organism evidence="3 4">
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        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_29275"/>
    <dbReference type="EnsemblBacteria" id="AKH85655">
        <property type="protein sequence ID" value="AKH85655"/>
        <property type="gene ID" value="AA958_29275"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_29275"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6173"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003115">
        <property type="entry name" value="ParB/Sulfiredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036086">
        <property type="entry name" value="ParB/Sulfiredoxin_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00470">
        <property type="entry name" value="ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110849">
        <property type="entry name" value="SSF110849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ParB" evidence="2">
        <location>
            <begin position="15"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH85655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="342" mass="36895" checksum="F7B906BAE516E479" modified="2015-07-22" version="1">MSEMLHEQLVSRDTHSFLISSLLPADSPRLAGEIEEHARILAESDAPLPPIVVNRSTMQVVDGMHRLRAASLRGQQRIEGWFVEGPAEDVFVLAVELNAKHGLPLSRKDRNAAARRIIESHPHWSDRRIASVTGLSPGAVGALRGAVDMPVAPLSLRVGRDGRVRPLNSASGRIAASQVIAESPSASLREIASRAGVALATARDVRNRLRMGLDPVPPKLRAAEADCAAVAAPGPTDSGTVPDQSGVSFENVLARMRRDPSLRMSQTGRALLRLLSSQQVPDEEWRDLVAGVPAHRAVDVAHAAQLCADRWLKFAAEVRVRRVQSEDRAPEDGGLRRLSPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NB34</accession>
    <name>A0A0F7NB34_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_23700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017968.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_23700"/>
    <dbReference type="EnsemblBacteria" id="AKH84713">
        <property type="protein sequence ID" value="AKH84713"/>
        <property type="gene ID" value="AA958_23700"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_23700"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4995"/>
    <dbReference type="OrthoDB" id="1204683at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="11"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH84713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="210" mass="21871" checksum="F11589B8D1716975" modified="2015-07-22" version="1">MATKQRGRPRSFDRDEALEKALYAFWQHGYEATSVADLTRVLGIGAPSLYAAFGDKKALFDAAVEAYATTDNGTFIDRALAEEPTAVAAFSRILREAAVGYTAPDHPRGCMVLSVGVSATTPEVVTKMRELRALNLAAMTARVQADVTAGVLPPGTDTEKLASYAGAVLQGMSAQARDGADRELLMRVAEVAAAGFAASAEGGQVGASGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NB97</accession>
    <name>A0A0F7NB97_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_23860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017991.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_23860"/>
    <dbReference type="EnsemblBacteria" id="AKH84739">
        <property type="protein sequence ID" value="AKH84739"/>
        <property type="gene ID" value="AA958_23860"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_23860"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5028"/>
    <dbReference type="OrthoDB" id="1356861at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH84739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="307" mass="31700" checksum="02090BFF592C31CF" modified="2015-07-22" version="1">MQDGSSGSVGRRHVLGGAAAAMAAAGVGLGAGARTASAQERGQQVKGGSYAGKTVLVTGATSGIGRAAAIAFAAEGARVGFCGRRRDLGQDVERQIRRAGGEATYLRADVRRPEEVRGFVDAVAQKYGGLDIALNNAGIQKPFTDLHEVSVADWDDVTLTNTRGIFLAMKYEIPHLRARGGGVILVTGSSNQYATRPGLGSYTASKNGVTGLVQAAAVENGTHGIRVVALAPGMTDTPMLDVHRPPGDTDEQWAARKAEFGRQGIDAFKRMATPEEMASAALALASDDMGFQTGTTVVVDGGQLAGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBJ3</accession>
    <name>A0A0F7NBJ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Fucose isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_19885</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017357.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_19885"/>
    <dbReference type="EnsemblBacteria" id="AKH84067">
        <property type="protein sequence ID" value="AKH84067"/>
        <property type="gene ID" value="AA958_19885"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_19885"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4190"/>
    <dbReference type="OrthoDB" id="507566at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008736">
        <property type="term" value="F:L-fucose isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006004">
        <property type="term" value="P:fucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.14.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.275.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038393">
        <property type="entry name" value="Fuc_iso_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015888">
        <property type="entry name" value="Fuc_isomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038391">
        <property type="entry name" value="Fucose_iso_dom1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012888">
        <property type="entry name" value="Fucose_iso_N1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038392">
        <property type="entry name" value="Fucose_isomerase_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009015">
        <property type="entry name" value="Fucose_isomerase_N/cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012889">
        <property type="entry name" value="Fucose_isomerase_N2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02952">
        <property type="entry name" value="Fucose_iso_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07881">
        <property type="entry name" value="Fucose_iso_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07882">
        <property type="entry name" value="Fucose_iso_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53743">
        <property type="entry name" value="SSF53743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="1" id="KW-0464">Manganese</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fucose_iso_N1" evidence="4">
        <location>
            <begin position="2"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="Fucose_iso_N2" evidence="5">
        <location>
            <begin position="253"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="Fucose_iso_C" evidence="3">
        <location>
            <begin position="331"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH84067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="472" mass="52885" checksum="7B04CE8C1DD7ADA6" modified="2015-07-22" version="1">MARIGLLSISDGRDYVQRDVRDHVSRAARELAAMLTDAGHEVIVAPEHVESNVLATSQARWLAERHVDVTIFHHSVWTFPHFTMLAAEATPGPVLMVANLDPQYPGMVGLLAGAGGLDQIGRVHARAWGDLAEPAVRDRILTHVRAGAAVQQLRGSTFGRIGGRPMGMYTATANTDQWMKVFGVDVEEIDQWEIVRRSENADAARVKNARTWIERHAAGVHYDGDRLTPELLERQIRSYYAMRELIEEWNLDFSGIKGQPELTAHFATMDVAEAFLNDPYDWEGPKETHVTSTEADMDAAMTMQLLKLLSGDPVLFADIRHYDSDKQVWDLCNSGQHATWYAARSDDPAENMRHVNFLPEVFYFPAGGASVQHLAAPGAMTFARLTRLRGEYRMHVMRGDLEQYDAETNERMMRATTWEWPHAFARLSPTAEEFLTRFGSNHIHAVPGDYVADLRAVCDQLGIAYDGFGDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBZ0</accession>
    <name>A0A0F7NBZ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Beta-glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_29815</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018954.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_29815"/>
    <dbReference type="EnsemblBacteria" id="AKH85726">
        <property type="protein sequence ID" value="AKH85726"/>
        <property type="gene ID" value="AA958_29815"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_29815"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6294"/>
    <dbReference type="OrthoDB" id="419160at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019800">
        <property type="entry name" value="Glyco_hydro_3_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="SSF52279"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00775">
        <property type="entry name" value="GLYCOSYL_HYDROL_F3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fn3_like" evidence="5">
        <location>
            <begin position="697"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="787"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="788"/>
            <end position="806"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH85726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="806" mass="84365" checksum="389DBD6DF087174C" modified="2015-07-22" version="1">MPTAESLPVTGRGAPRWRDPALPVADRVEALLAEMTVAEKVAQLGSRWTGNGTVHTVDDGAGRAGGPRVAPIQEVFESGSIPLADACRDGLGHLTRVYGSRPVTPVEGAAELVRSQHTVLRGSRLGIPALVHEECLTGFTTYGATVYPAALAWAATFDPELVRRLGAAIGRDMRAVGVHQGLAPVLDVVRDYRWGRVEETMGEDPYLVSMLGAAYVAGLEGAGVIATLKHFAGYSASRAARNHGPAPLGRRELADVMLPPFETAIAVGGARSVMNAYSEVDGVPAGIDSWLLTDLLRGDWGFTGTVVSDYGAVAFLAGMHGVAADTEQAGVLALSAGIDVELPDTLGFGPHLVERVGRGELSESLVDRAVRRLLTQKVRLGLLDPGWTPEGSVAAAAEVDLDSPENRELAAELAERSVVLLDEGSALPLLGAGRTAPGRLAVIGPCAADSRTLMGCYAFPNHVLPRHPGLGLGVAAPTVLDALRRELPDTGIRHEPGCEVSGDDRSGFAAAAAAAREADLCVAVVGDRAGMFGNGTSGEGCDAEDLRLPGVQADLLAELFATGTPVVVVVVSGRPYALGDVHPRAAGLVQAFMPGQEGAAAVAGVLSGRVQPAGKLPVQIPRRPGGQPGTYLQPPLGGNSHGISSIDPTPLFPFGYGRSYTTFEVDDPRVSAVEIPTDGEFAVSVRVRNTGARAGHEVVQLYLRDVVAQVTRPARQLAGFVPVRLEPGESARIRFHVHADRTAFTGRDLRRIVEPGEVEALVGTSSADLPCRVTVRLTGPTRVVGHDRRLTTPVDRQQGEADADGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NC01</accession>
    <name>A0A0F7NC01_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Racemase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_29885</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018964.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_29885"/>
    <dbReference type="EnsemblBacteria" id="AKH85736">
        <property type="protein sequence ID" value="AKH85736"/>
        <property type="gene ID" value="AA958_29885"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_29885"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6311"/>
    <dbReference type="OrthoDB" id="743369at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013341">
        <property type="entry name" value="Mandelate_racemase_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02746">
        <property type="entry name" value="MR_MLE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="SSF54826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MR_MLE" evidence="2">
        <location>
            <begin position="137"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="381"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH85736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="411" mass="43582" checksum="8C6FC0A7B07DEA63" modified="2015-07-22" version="1">MRITGYRTLTTLLDWGRPVGDANGVLTDGITPVPVVLVDTDAGITGVGLGPHAAGEAVFPAVDGEDPRCVGALYDGMLRQAFKAGHGGTVFGTIGAFDTALWDIKAKAAGEPLWRLLGGRDRRVPAYASGLDIALGDDDLATVYQVYAERGLRAAKLKGGLDIERDRDRLTLVREVLTRAGRGMRPALMLDVNENWTRKQAVRHVRELEQTLDLTWVEEPVRRWDAEGLAAVGRGIRASVASGENLTGLEQYRPLLAQGAVDIVQAAAVWGVTHFLRVAALAHAHDLPVSPIGGSPIALLHAATAVPNHLASELQNLLEPVGLSFDLRVEGGAFVLGDSAGLGVEVDEEAIAAAVRPEPPAACEGPDVRPEYAGRRLLAVEDRGRPATHPPGLPVPSPPQHLDGVPHDARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NC72</accession>
    <name>A0A0F7NC72_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_25575</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018279.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH85029">
        <property type="protein sequence ID" value="AKH85029"/>
        <property type="gene ID" value="AA958_25575"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_25575"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5392"/>
    <dbReference type="OrthoDB" id="2047542at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="10"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH85029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="218" mass="23457" checksum="765AFB31B8358634" modified="2015-07-22" version="1">MRTPMRADARRNRELILKAAGEVFVGEGPDAPLEDVARRAGVGIATLYRNFGSREALIRGVAAATLAELRGAAEEALAGGDEPFEALRRFAHTALNLRIGAVLPALSGRIRIDEELAELRARTLRPVQELIVRAQQAGRLRDDVVFGDVPFMVMRLTLLLPGGGFAEDEALAHRHLELYLDGLRPEAARARGAGLPGPAITAARFIRATDRIVGGNDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCC3</accession>
    <name>A0A0F7NCC3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lysophospholipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_32300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019358.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_32300"/>
    <dbReference type="EnsemblBacteria" id="AKH86130">
        <property type="protein sequence ID" value="AKH86130"/>
        <property type="gene ID" value="AA958_32300"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_32300"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6819"/>
    <dbReference type="OrthoDB" id="1694750at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydrolase_4" evidence="1">
        <location>
            <begin position="25"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="306" mass="33432" checksum="BB1DC71DDC597034" modified="2015-07-22" version="1">MHSDHLQAADGTPVASYTWLPEDDRPRALVQIVHGAAEHGLRYDRFARFLAAHGYAVAASDHRGHGATAATGGYGVTGTGDADPWRAVVDDLTAVGDRLRADHPGLPFVLLGHSMGSMLARDYAQEHGEGLAGLVLTGILRSLPGVETETAVRRLAGEAAERGRGALSDFVPEIFASFNDPYEHRTGFEWLSRDTAEVDAYVADERCGFPFDVALSLGWVLGTRKINDPYNVARIPVDLPVHIAVGDRDPCNQGLTHVAELLEDFRYAGLREPTWRAYPGARHEILNETNRAEVQADLLDWLDKHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCE1</accession>
    <name>A0A0F7NCE1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_32430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019377.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86150">
        <property type="protein sequence ID" value="AKH86150"/>
        <property type="gene ID" value="AA958_32430"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_32430"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6845"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="261" mass="27181" checksum="ADE8952F9C3CBCD7" modified="2015-07-22" version="1">MTTRTAALIRRLDLDPGVLRLLSVTFLWVALTCTALLIPISLTLLPGYEAWKFTTRDIAPAIGLAAGFTLAAALLAGSRTSLKAAAARFVTALGLRPGTRRTATVSLAAGLGAGALCLAAAELLVRIPALSATPASEDPRNAAVAGTSTTVHLLDGALSAPVHEELLFRAPLLLLLTFLATPGARETIPTPRLRRTTFTAAAALSALVFTAGHELGGPVNLIFAAFLAAVTTALLLWRRSLVPCIVAHTVHNTAITALWLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCG9</accession>
    <name>A0A0F7NCG9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_26370</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018410.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_26370"/>
    <dbReference type="EnsemblBacteria" id="AKH85169">
        <property type="protein sequence ID" value="AKH85169"/>
        <property type="gene ID" value="AA958_26370"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_26370"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5551"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018391">
        <property type="entry name" value="PQQ_beta_propeller_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002372">
        <property type="entry name" value="PQQ_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13360">
        <property type="entry name" value="PQQ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00564">
        <property type="entry name" value="PQQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="16"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH85169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="746" mass="78487" checksum="7314EFBC255FA5BE" modified="2015-07-22" version="1">MATPLTHDDPQQLGPYRLVARLGSGGMGTVYLARSAGGRTVALKTMHADLVSGEAGTAGAEFRTRFRLETDAARVIGDHYGAEVVDADPLAETPWLATEYVLGPPLDEAVAVSGPLPETTTRALGAALCEALGQLHRSGVVHRDLKPSNILLTAAGPKVIDFGIARAAGDDHLTRTGTAAGTPAFMSPEQASGVEHTPVGDVFALAGVLVFACTGHGPFGGGQAADLLYRVRYGEADLSGVPAGLLPLLQRCLAKEPETRPGTDELAMLLAEGLPDGTADFADQLPDALHADILRRAAVAWQPQPPRLPSPHQAAMETELGAGPGPSRRKVLALAGAGAVAVGGAGMGAWAYLRDDEKEPAARPKAKKPKAPKELWTRPVVGGGGAFSLATGGNYVLLLTTTGGGQFVDARNGKLRGVSQVLSPSLGIIGDDSGFYSVGSRSVSGEGTHALFTNDPETGDSEEDVVLNGADVRGTAIEAAENGIVLLRASTRWVTRVYRDKKTKKKIVEKTPWTSQFVAADMETGELLWGFDNKSPDTGPSYATALTKNEALIRVESTLTCIDARSGEVRWTWKAPKEDRESLAGLQQFPTAKGHVLLGLRDLTALRLSDGEVGWSVGEGREARAALGPDTRLYGTPAVKDGKVYVVENGNGLIAIDGASGEVEWEARADWAGPQAFIVAPVVGEKYAYVGTGGRDWVRAVDLEQHKTAWSYRGPEDNERPMVLAQDDAKVVLVVTAADVRGLPLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCS5</accession>
    <name>A0A0F7NCS5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_26955</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018510.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_26955"/>
    <dbReference type="EnsemblBacteria" id="AKH85274">
        <property type="protein sequence ID" value="AKH85274"/>
        <property type="gene ID" value="AA958_26955"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_26955"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5672"/>
    <dbReference type="OrthoDB" id="1905807at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021443">
        <property type="entry name" value="DUF3093"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11292">
        <property type="entry name" value="DUF3093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="150" mass="15911" checksum="AAAD4CF85A8E70C4" modified="2015-07-22" version="1">METTQSYDERLSAPRSWWGLAVGAGVCLALVLTPFGTLPLLAGLAGGTALAAVGVSSYGSARIRIVAGKLVTDDARVPLTALGEARALDAEEARAWRTHKADTRAYMLLRGYIPTAVRVEVTDPEDPTPYLYLSTRQPERLVAALKSAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDB6</accession>
    <name>A0A0F7NDB6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_33015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019468.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86241">
        <property type="protein sequence ID" value="AKH86241"/>
        <property type="gene ID" value="AA958_33015"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_33015"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6975"/>
    <dbReference type="OrthoDB" id="794648at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008701">
        <property type="entry name" value="NPP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33657">
        <property type="entry name" value="PTHR33657"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05630">
        <property type="entry name" value="NPP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029958">
        <property type="entry name" value="Necrosis-inducing_protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519522" evidence="1">
        <location>
            <begin position="31"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="259" mass="27686" checksum="19421D9075E09798" modified="2015-07-22" version="1">MRSSSRIRRVSAVLGGAFALVVALPHAASAAAAAPPQALPANADGLEQTFQPAYDYDTDGCYPTPAIGPDGTVNPGLEPGGALDGGCRDAADLDNTNGYSRAKCNNGWCAVVYGLYFEKDQALPGTGLFGHRHDWEHVVLWIRDDQAQYVSTSAHGDFDTYPRDQIRWDGTHPKVVYHKDGVGTHAFRPATGNDEPPENHHGGWQFPDLVGWNGYPAGLRDKLSTTDFGSANFGLKDSSFVSHLEKALPAGIPFDPGAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDF0</accession>
    <name>A0A0F7NDF0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HisKA_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_02940</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019746.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86520">
        <property type="protein sequence ID" value="AKH86520"/>
        <property type="gene ID" value="AA958_02940"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_02940"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.628"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519335" description="HisKA_3 domain-containing protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="3">
        <location>
            <begin position="383"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH86520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="573" mass="60048" checksum="90D5F54F8AAE1394" modified="2015-07-22" version="1">MRCWTVAAALAAVVSGGVGAWAYAGTGASTADLLRDLAVGWAYAGAGLAAWWRRPANATGPLMTAVGITWFIGNLQGTTIPALFALGAWWEGLNVAVLAHLVLAYPDGRTGSPATRRIVLLGYGLVATGGLLRTLAFDPAAHPGGSYLACRDCGPNPLFTPALSDLFPTFDAGFRAIGWAVSLAVVVAVVRRWRRASAARRRALLPAWLAVLVATSFLLWDVLVVLVPAGEPVEGAVGVFSDVAQTAVPLAFLVGLLRMRLQRAEVGGLVMEVGGDPDPGRLREALVPVLGDPGLRLGVWRPAAGAYVDAAGDPVEEAATGSTRIDAAGGAPLALLRHDPAVAQDEELLRSAVAALRLALENVWLQAEARAAGARVVEAADSERRRLERDLHDGAQARLVFALMTLRRVEKGLADHPDEELRRSVAEVERSLRLAVEELRGLAHGIHPAVLTREGLASALRELAGRAELPVVVAAEDRRFAPHVEATAYFTVSEALANSAKHARARAVSVSARHRDGRLVVEAVDDGIGGARHDHLGGGLRGLADRVSAVGGVLTVHSPPGGGTRVVAELPCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDY3</accession>
    <name>A0A0F7NDY3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_00015</name>
        <name evidence="3" type="ORF">AA958_34245</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH80825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014192.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH80825">
        <property type="protein sequence ID" value="AKH80825"/>
        <property type="gene ID" value="AA958_00015"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86446">
        <property type="protein sequence ID" value="AKH86446"/>
        <property type="gene ID" value="AA958_34245"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_00015"/>
    <dbReference type="KEGG" id="strc:AA958_34245"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH80825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH86446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="114" mass="12694" checksum="04F7635B5EFDD84C" modified="2015-07-22" version="1">MGFYEIVSVGDGQARRMSEPMDWDGMLSDLAQVEVSGRTVDADARLVGTLVTHDMQDHLLLHRVKGAGEWLSVLNYRTGALRELEESAQEGYLDTSVTPPAREERHPEERSPAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NE14</accession>
    <name>A0A0F7NE14_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Corrinoid adenosyltransferase</fullName>
            <ecNumber evidence="4">2.5.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Cob(II)alamin adenosyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Cob(II)yrinic acid a,c-diamide adenosyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Cobinamide/cobalamin adenosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_24940</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>2 ATP + 2 cob(II)alamin + reduced [electron-transfer flavoprotein] = 2 adenosylcob(III)alamin + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 triphosphate</text>
            <dbReference type="Rhea" id="RHEA:28671"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16304"/>
            <dbReference type="ChEBI" id="CHEBI:18036"/>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="EC" id="2.5.1.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>2 ATP + 2 cob(II)yrinate a,c diamide + reduced [electron-transfer flavoprotein] = 2 adenosylcob(III)yrinate a,c-diamide + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 triphosphate</text>
            <dbReference type="Rhea" id="RHEA:11528"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18036"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:58503"/>
            <dbReference type="ChEBI" id="CHEBI:58537"/>
            <dbReference type="EC" id="2.5.1.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 2/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the Cob(I)alamin adenosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.17" evidence="4"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018163.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_24940"/>
    <dbReference type="EnsemblBacteria" id="AKH84912">
        <property type="protein sequence ID" value="AKH84912"/>
        <property type="gene ID" value="AA958_24940"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_24940"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5257"/>
    <dbReference type="OrthoDB" id="1401910at2"/>
    <dbReference type="UniPathway" id="UPA00148">
        <property type="reaction ID" value="UER00233"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008817">
        <property type="term" value="F:cob(I)yrinic acid a,c-diamide adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016030">
        <property type="entry name" value="CblAdoTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036451">
        <property type="entry name" value="CblAdoTrfase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029499">
        <property type="entry name" value="PduO-typ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12213">
        <property type="entry name" value="PTHR12213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01923">
        <property type="entry name" value="Cob_adeno_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89028">
        <property type="entry name" value="SSF89028"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00636">
        <property type="entry name" value="PduO_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cob_adeno_trans" evidence="5">
        <location>
            <begin position="7"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU366026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH84912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="190" mass="20632" checksum="690B38161037EAC2" modified="2015-07-22" version="1">MVNLTRIYTRTGDKGTTALGDMSRVPKTDPRISAYADANEANAVIGTALALGGLSEEVARVLTRVQNDLFDVGADLSTPVRPDPEFPPLRVEQEYVDRLEADCDRFLAGLEKLRSFILPGGTPGAALLHQACTVVRRAERSTWAALEVHGETMNPLTATYLNRLSDLLFILARTANKAVGDVLWVPGGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NE55</accession>
    <name>A0A0F7NE55_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Beta-glucosidase</fullName>
            <ecNumber evidence="3 11">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AA958_02785</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="3 11"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019741.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_02785"/>
    <dbReference type="EnsemblBacteria" id="AKH86516">
        <property type="protein sequence ID" value="AKH86516"/>
        <property type="gene ID" value="AA958_02785"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_02785"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.596"/>
    <dbReference type="OrthoDB" id="654705at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102483">
        <property type="term" value="F:scopolin beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018120">
        <property type="entry name" value="Glyco_hydro_1_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017736">
        <property type="entry name" value="Glyco_hydro_1_beta-glucosidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033132">
        <property type="entry name" value="Glyco_hydro_1_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="PTHR10353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00131">
        <property type="entry name" value="GLHYDRLASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03356">
        <property type="entry name" value="BGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00572">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00653">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="6 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="408"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8 10">
        <location>
            <position position="354"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="401"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR617736-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR617736-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AKH86516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="453" mass="50214" checksum="F4CBA5AA2BDA1D90" modified="2015-07-22" version="1">MTDLHLDRLPSDFVWGTATAAYQIEGAVREDGRSPSIWDTFSHTPGMVDGGDTGDTACDHYHRWPEDIALMRRLGAGAYRFSIAWPRVVPGGDGPVNEAGLAFYDRLTDALLEAGITPFPTLYHWDLPQALQERGGWAERATAEAFAAYADAVARRLGDRITDWATLNEPLCSAWIGHLEGRMAPGLTDLTAAVRASYHLHLGHGLAVQALRAAVPGARIGLVNNLTHCEPASDRDEDIAAAARADGHTNRWWMDPVHGRGYPEDMRRLYGVDLPEHPGDLETIAAPLDWLGLNYYFRQVVADDPDGPLPYARQVDLPGVRRTAMGWEVHAEGLTKTLERMADDYRARCLYVTENGAAYPDAVGPDGRIDDPERTRYLEEHLAACAEAVRRGVPLAGYFAWSLLDNFEWAYGYDKRFGLVHVDYATQRRTVKGSGRRYAELIRGHRAAARRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NEE4</accession>
    <name>A0A0F7NEE4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cellulose-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_29860</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018961.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_29860"/>
    <dbReference type="EnsemblBacteria" id="AKH85733">
        <property type="protein sequence ID" value="AKH85733"/>
        <property type="gene ID" value="AA958_29860"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_29860"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6306"/>
    <dbReference type="OrthoDB" id="179460at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004560">
        <property type="term" value="F:alpha-L-fucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016518">
        <property type="entry name" value="Alpha-L-fucosidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027414">
        <property type="entry name" value="GH95_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14498">
        <property type="entry name" value="Glyco_hyd_65N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007663">
        <property type="entry name" value="UCP007663"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519355" evidence="1">
        <location>
            <begin position="29"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hyd_65N_2" evidence="2">
        <location>
            <begin position="48"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH85733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="816" mass="88221" checksum="D15720BD3BA87B26" modified="2015-07-22" version="1">MRRLTRREMIRLGTAGTGAVMMPVPWTAAARADSAAPPEVRAVDDLALWYDAPAGSDWLRALPVGAGRLGAMVFGNVGTERLQLNEDTLWAGGPYDPANPAGADALPQIRQLVFDGQWEQAQSLIDRTMLGRPAGELAYQPVGDLTLTFPGSGGTSGYRRWLDLTTATTAVTYAANGVRFHREVIASAPDQLIVMRLTADAPGSISFTATFASPQSSSASSPDGTTIALEGISGSMEGIAGSVRFLALARAVAEGGTVSGSGGTLRVAGADSVTLLVSIGTSYVDYRNVGGDYRGIARKHLDAAQGIAYDDLRDRHVADYQELFGRTTIDLGRTGAADQPTDVRIAQHGNADDPQFSALLFQYGRYLLISSSRPGTQPANLQGIWNDQMAPPWDSKYTLNANLPMNYWPAGSTNLAECCEPVFGMIDDLAATGARTARVQYGAGGWVAHHNTDAWRGTSVVDGAFWGMWQTGGAWLATMIWDHYQYTGDVGFLRAHYPAMKGAAQFFLDTLVEEPDLGWLVTNPSNSPELAHHPNASVCAGPTMDMQILRDLFDGCARAGEILGVDADFRGEVLAARERLAPTRIGARGNIQEWLYDWTETEQFHRHVSHLYGLHPGSQITKRGTPELFEAARRTLELRGDDGTGWSLAWKINFWARMEEGARAHELIRDLVTPERLAPNMFDLHPPFQIDGNFGATSGIAEMLLHSHHGELHLLPALPPAWPNGRVEGLRGRGGHTVGAAWTGGQATWLSLTPDRDGTVKVRSRMFRGGYQLLDLTGGGQVRPEQPEPDLIEFAARSGHTYRANALGSRRGGDEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NEG1</accession>
    <name>A0A0F7NEG1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_30020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018986.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_30020"/>
    <dbReference type="EnsemblBacteria" id="AKH85758">
        <property type="protein sequence ID" value="AKH85758"/>
        <property type="gene ID" value="AA958_30020"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_30020"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6339"/>
    <dbReference type="OrthoDB" id="1320028at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="2">
        <location>
            <begin position="26"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH85758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="486" mass="51479" checksum="4C9027F8B240CBF7" modified="2015-07-22" version="1">MPRIRTNSSTAEDLLIELDRDRTRAEPLHRQVAASIRESVRAGRLRHGASLPPTRTLAAGLGVSRGVVVEAYQQLVAEGYLTSRAGGYTQVALEQGGTADSARAAAPSAPAGTQGAAPAVDFGYGHTDVSTFPRAAWLRSVRTVFAATPNERFAYLDGRGVPELHQALADYLNRVRGTSASPRHTVICSGFGQGVSLLVQVLAARGARRLAVEDPSPDDDARPLAAAAGLDVVGVPVGPDGIRVEELEKADADAVVLTPSHQWPTGGVLSAAARARVIRWAQRRGALVIEDDYDAEYRYDRAPVGAIQGLAPDHVVYCGTASKTLVPGLRLGWMLVPPHLVDDVARAKLLADRGSSVIDQLTFADFLARGEFDRHLRRMRPVYRRRRDALLAALDARLPELVPTGVAAGQHVVAWLPPDLDEAAVVAAAARRGVALRGVARYRLDPAGPGGLIFGYATLSERAIAAGIAGLARAVTDVRGPRGAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NEJ0</accession>
    <name>A0A0F7NEJ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_11960</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019973.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_11960"/>
    <dbReference type="EnsemblBacteria" id="AKH86701">
        <property type="protein sequence ID" value="AKH86701"/>
        <property type="gene ID" value="AA958_11960"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_11960"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2516"/>
    <dbReference type="OrthoDB" id="1812408at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="260"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="19"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH86701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="288" mass="31290" checksum="0506B9487C397554" modified="2015-07-22" version="1">MDAAVTRVGEERDSAWERAARLTVLERELSQELERLTGELAQVKEQTYAELGPRAQEILYLAQEQAAELRGTAAEQLQRAEAETRRYVEETTADTRRAANALREEAEARLRSALGAAEQEAADLLASAHAAVEDTAGEAAAALAEMKHRTAAMLDEASLERTAAARRLDEEVRERRQAIDADLATRTRAAEAHLAEQQAAHAEAEAYAARCRDEAEAQGAELVAEAVAQAEQIERDTQRALREAEGRREELAAHMEHVRATLTAMTGRAPDSDPATGTVPGPSPHGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NEM9</accession>
    <name>A0A0F7NEM9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AAA_31 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_26360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018408.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_26360"/>
    <dbReference type="EnsemblBacteria" id="AKH85167">
        <property type="protein sequence ID" value="AKH85167"/>
        <property type="gene ID" value="AA958_26360"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_26360"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5549"/>
    <dbReference type="OrthoDB" id="2013820at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_31" evidence="2">
        <location>
            <begin position="988"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="942"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1238"/>
            <end position="1295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="546"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="643"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="678"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="800"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="831"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="860"/>
            <end position="874"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH85167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="1295" mass="130521" checksum="5ADA8736128BFFCA" modified="2015-07-22" version="1">MSSDRDENGAGRTSPDVERSATEPEGTGEFTSSPAPAAWYTQGVPPPSTRQDEEAGTGSSHAGSAMPPLPNGFTAAHAPAPGPVPESMTPPPFLLTLPDEPPEPPPVPEPTTPPEPEAAPVAPAAAEPAADRDEDDERDDGRDDGQDEPYADEDDSPPLTAATDPAAVAFAALPAAPAAPEAGTDGEGDAGTDDGAAPAAEAEEFSSSPVSAPSWYGGGASATSAGAEAHDERDTASAAPEADEDPADATARSADADDDRDTGSDSSATGETSGEDDATGTDRPSLPEAIPAAQTDDDSPSSGAGWPSLPEAAPAAQAGEDDRADDTSWRSSEPESGWPSPSADAAGERAADDEPAAAARTDETPEAEPEAPGTDWQSATDWHSTAAPAADGGEASGSDASWPIPAASPAGDEEAAEAQEPAATSSGTGRQDAAAGESAGSGSAWPSFAGAQEAADDGTDASGEGTEAPEAGAAWPPVPGTQPAAEADDGASAAAVSAFPAPQFAAPPRPDDDEAGTPAPYRDDATRTLTPLVAHAAPGAAARADQDQEQGRDEDAAQDEPDRGDVVSGATMRFSPASLRAQAAEVQDRTPAGDEPNDAVPASAEVQDRVPAHAAPARDDEPQDAPPQASPYATDSAPAGANPWAPAPAPDESASPTALPPLPPQFPAAEQQRPQAADLPSGPPPAPGAPWQSPAPRPAPEQSAPQPPAAPPAAPSAPPAAAPQQQPYPGLPAPGAAPAASAPPPAAPAAPAAGAEAPRSGPAAEPPPGWTVASPSGVPVAPAAQQPDSGAPQGGYGWPQPPAAQQNQPGRQGEQGRQAIPGQQSQPGEQPGPYPGLPAPPPQQGRQPGHQAQPGQPGQLPAQPAQPAQQPPGLPPAGGAQTGAPGQGALSPATSPAPPAQPGGDPRSGGWPDVTPEQRRQPVHNAPLGYTAAVELSSEQLLHDKHKPQRKSERGGLSRFKLGGKAAEEERQRKIALVRTPVLSCYRIAVISLKGGVGKTTTTTALGATLAAERQDKVIAIDANPDAGTLGRRVRRETGATIRDLVTAIPYLNSYMDIRRFTSQAPSGLEILANDVDPAVSTTFNDEDYRRVIDVLGKQYPVILTDSGTGLLYSAMRGVLDLADQLIVVATPSVDGASSASTTLDWLHAHGYADLVSRSITVISGVRETAKMIKIDDIVNHFKQRTRAVQVIPFDEHLSAGAELDLSMMRPKTKEAYFNLAALVAEDFTRAQQAQGLWTGEGGQQPPHAMPPLPGQAGGAGGYGAGGGYPGGGGYPGGAPGTGPSQAQSGPSPYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NER0</accession>
    <name>A0A0F7NER0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_20150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020266.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_20150"/>
    <dbReference type="EnsemblBacteria" id="AKH86920">
        <property type="protein sequence ID" value="AKH86920"/>
        <property type="gene ID" value="AA958_20150"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_20150"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4243"/>
    <dbReference type="OrthoDB" id="1020158at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031423">
        <property type="entry name" value="Phosphatase_SCO2771"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15698">
        <property type="entry name" value="Phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH86920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="272" mass="28405" checksum="7D3FDC4FA7F2E3A4" modified="2015-07-22" version="1">MLTDAPLLRRHLLATGIAGPVATSRDKSLRRYQQFAARDPRVLLGLEPERDWSVAELLRLMAERCGTSGDPGRISGTEVIDPDRTIDALHAFAKRLRDAARDCEAVLFGTGHPDRLLGFYALLAAGLSAAGCVVLTPGEGRDVDITTRFGVRTYRLNYPGSVAVLGDPGLSAGPATRGVHTHSPLPLRAALGAAAAAGGPLPGLVVGDHGWACGAGQLGIEAIGLADADDPALFVAQVEGQVSVVVPLDDSVQPDSYGPVADYVLKHARLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NEX4</accession>
    <name>A0A0F7NEX4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_31560</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019232.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_31560"/>
    <dbReference type="EnsemblBacteria" id="AKH86004">
        <property type="protein sequence ID" value="AKH86004"/>
        <property type="gene ID" value="AA958_31560"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_31560"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6666"/>
    <dbReference type="OrthoDB" id="1438064at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH86004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="200" mass="21781" checksum="693B5636EB0E1E46" modified="2015-07-22" version="1">MSEPDTEAPDAVWDAYLPPVKILVAGGFGVGKTTAVGAVSEITPLRTEERLSAAGVGVDDLSGIEQKSATTVAMDFGRITLDVAVLMLFGTPGQERFWFMWDDLLRGALGAVVLVDTRRLDRSFAAVDFFESRDLPFVVAANCFHGEQDYDPEEIRDALTLKEPTTPIVLFDARERESVRGVLLALMDHLIAAAEPARAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-12-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFF6</accession>
    <name>A0A0F7NFF6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_31980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019301.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86073">
        <property type="protein sequence ID" value="AKH86073"/>
        <property type="gene ID" value="AA958_31980"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_31980"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6753"/>
    <dbReference type="OrthoDB" id="1070946at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH86073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="285" mass="30643" checksum="E7C7FD6A865490E2" modified="2015-07-22" version="1">MTSFFSHQQIEHFRAFGYVVLRGLLTYEETDRLTAEVTTALTDAYGGLGTDTDPCGEGGIRGDYLPLAADRTPFSQSLIADDPRLFQGSAELCGRMTVPAVPSAVCFTSNSGWHTDVGPDVPGVTFLAHLEPRTARTGALRVVPGSHDPAYARRLAAYHDLDPANQGFPGWPVPETVLPTEPGDVLAFDAHLLHRSVGGGNRLAWRTEYLGWPGLGDAEGMRTVGELLAEDAYEDAGFDRARWPEWDEWAAGAAGIASRQTALDRLRLLGVVPQARTAARAPAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFZ9</accession>
    <name>A0A0F7NFZ9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phosphate transport system permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AA958_29385</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018901.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_29385"/>
    <dbReference type="EnsemblBacteria" id="AKH85672">
        <property type="protein sequence ID" value="AKH85672"/>
        <property type="gene ID" value="AA958_29385"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_29385"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6201"/>
    <dbReference type="OrthoDB" id="1325025at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011864">
        <property type="entry name" value="Phosphate_PstC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02138">
        <property type="entry name" value="phosphate_pstC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="25"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="78"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="117"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="156"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="278"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="330"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="384"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="419"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="450"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="494"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="570"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="80"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="380"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AKH85672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="602" mass="62415" checksum="B61D19631861F383" modified="2015-07-22" version="1">MTVKTLVRQPVPPDEAPRPRPSRWIWGWVFTGALSVAAVLVVLVGYLGAGLGSGDVDWPELLTDPSWSPTYSTFGGLAMIYGSVVVCLIALAIAVPVSWAAAVALSEYLPPRLARPLRLCVELLAAVPSIVYGLIGILIIRPVIAQMADVPGGDSLLAAGIVLAVMITPTVVAVSVDALAAVPDRYREAAFSLGLTRREVIRSAVLPLAKPAMRAAVLLGLARALGEAIAVFLVVGRADGRLPTTFGEFLDSLVHPGQTLTTKLAGPEPVLAGTSGPYFAALCGLGIILLTLVAAATVFGTRGASRTASSRRVSYRPAARMRMQQDRLIAALRLGALLLPTAVLVAMLALLATRGSSAFNPSFWFTSATGAAGGGVRDQIVGTLLLIATTGLISLPLGFGAGILMGVHASERTARLLQTMTVVVGGAPTILLGLAGFVILSSTMGWGRSWLAGAIVLVPVVVPIVALTTASRVRSMSPELTESALSLGLTRAQFIRSVVVPFAWPATVTGLLLGLARAAGETAPLLFTATVFFGAPALPDGIVNSPVQALPTHIFTLSQDSGDPQAVAQAWGSAMVLVLITAVLLSVAVALRNRLEGERWTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NG52</accession>
    <name>A0A0F7NG52_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_29790</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C56 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018950.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_29790"/>
    <dbReference type="EnsemblBacteria" id="AKH85722">
        <property type="protein sequence ID" value="AKH85722"/>
        <property type="gene ID" value="AA958_29790"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_29790"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6289"/>
    <dbReference type="OrthoDB" id="1421548at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006286">
        <property type="entry name" value="C56_PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42733">
        <property type="entry name" value="PTHR42733"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51276">
        <property type="entry name" value="PEPTIDASE_C56_PFPI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DJ-1_PfpI" evidence="2">
        <location>
            <begin position="2"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH85722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="187" mass="20255" checksum="D6AEF9BC09DC2573" modified="2015-07-22" version="1">MKKVLVLVGDAAEELDTMYPIFRMREAGHQVDVAALTRRDVQLVIHDFEPGSDAYTEKNGRRLPVDLAFSEVDPTGYAGLIIPGGRAPEYIRLDADVRRVTEYFFARNLPVGTVCHGPQVPAAYGLLKGRKTAAFGPLAADMENAGATVVDGPDVVDGNMVSCRGWPDLPEWSRAFVAVLERSAGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NGC7</accession>
    <name>A0A0F7NGC7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_33660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019580.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86358">
        <property type="protein sequence ID" value="AKH86358"/>
        <property type="gene ID" value="AA958_33660"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_33660"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.7107"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="96" mass="10546" checksum="63D87B0842698B6E" modified="2015-07-22" version="1">MIRRESYCGGRLVKEVGQVRDGRAPSDSAAPGGDGPALWLLDGERVEPAEAEAFWVVWTSVRRRHPLDETARSWPVVTIGCAIVLWLVTMVLTQSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NGG3</accession>
    <name>A0A0F7NGG3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Shikimate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_03200</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019751.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_03200"/>
    <dbReference type="EnsemblBacteria" id="AKH86524">
        <property type="protein sequence ID" value="AKH86524"/>
        <property type="gene ID" value="AA958_03200"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_03200"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.682"/>
    <dbReference type="OrthoDB" id="1054867at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004764">
        <property type="term" value="F:shikimate 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041121">
        <property type="entry name" value="SDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013708">
        <property type="entry name" value="Shikimate_DH-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022893">
        <property type="entry name" value="Shikimate_DH_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21089">
        <property type="entry name" value="PTHR21089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18317">
        <property type="entry name" value="SDH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08501">
        <property type="entry name" value="Shikimate_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Shikimate_dh_N" evidence="3">
        <location>
            <begin position="9"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="SDH_C" evidence="4">
        <location>
            <begin position="239"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF18317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH86524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="278" mass="29013" checksum="36C23B6F1576FC6A" modified="2015-07-22" version="1">MAQTRRAAVLGSPITHSLSPVLHRAAYGELGLTGWTYGRYEVDERRLAGFLDSLEPGEWAGLSLTMPLKRAAIPLLDEVSATARSVEAVNTVVLHDDGRRFGDNTDIPGITAALRERGIEKVERAAVLGAGATASSALAALASVCTGEVTAYVRSAARATEMEQWGERLGVSVRCTDWSQAAAAFDAPLVVATTPAGATDALAAAVPEHPGALFDVLYEPWPTPLAGAWAARGGTVVGGLDLLVHQAVLQVEQMTGVARAPLAAMREAGEAALRARTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NGY8</accession>
    <name>A0A0F7NGY8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_05405</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_05405"/>
    <dbReference type="EnsemblBacteria" id="AKH86563">
        <property type="protein sequence ID" value="AKH86563"/>
        <property type="gene ID" value="AA958_05405"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_05405"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1133"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH86563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="669" mass="70594" checksum="DB144AA098941D1A" modified="2015-07-22" version="1">MSFAAVPNARTADTPRVDLRVLVVDDGGEPVAAIAEHLAAIGTPVTAVRLGERGRPRIDAEFLAGAEEGRPRARYQAVVVPGGGGAREPGGGVAGAVPAVAAGGRGPVGAAAPVLGGARAPALGRAETAALAAYERRFGIRQVDAHAAAGPLPALGAPAWSGRLDGRTARVTPAGRAGPFGYLAGPVPFADLDPRAAETYGRLVRPGPDFTPYVDAAVPGKPRARGALVGEYADDGRRRLLVTFGAPGDRLAYRLLARGIVDWATGGVHLGAARYGFAVQVDGVLARDARWDPDGDCTSGTPGCADLPPIRMNRGDAAYARDWSARRDFTLDLVYSGGAAERHRRAHGGADALADRLITDREAFRWINGTYDRAPLGCVRGRGGDAARCARDAAGEVRWTPERRIALQIEENVRWGRARNLPVRRDELVTAGHTGLAAPPGQPLDNPDLAPALGTTGVRWLAADRARDPLSRRVGTASTVPRYGLGLFAGAGTEREQIDAHAYRYGEGSRGEDGDPAGGYRSYLVPRAARAALGHVLAADPAPHHLHQSNLAEDRIAYPLLDRVLTDYRRLFTSGTPLGNPRPRAIARDLQRRAVWAEAVRNGKVTAYRVGGTVTVRAPAGVEVPVTAPPGTRQRFSRGDAEVGRPYAGRAAGWTRADPVRERVVLRLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NH67</accession>
    <name>A0A0F7NH67_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_08775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019881.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_08775"/>
    <dbReference type="EnsemblBacteria" id="AKH86623">
        <property type="protein sequence ID" value="AKH86623"/>
        <property type="gene ID" value="AA958_08775"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_08775"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1849"/>
    <dbReference type="OrthoDB" id="2042592at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="106" mass="11418" checksum="6E5A379A572586E3" modified="2015-07-22" version="1">MRYRVSFVAGIAVGYVLGSRAGRERYEQLRKAAQQFSESPAVRNAAEAAALTSRDAVTKAASTLSTKFADVVPENVASRVHFLGSGHANGTRGRREESDDWGTTNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NHB3</accession>
    <name>A0A0F7NHB3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">1-hydroxy-2-methyl-2-butenyl 4-diphosphate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_32220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019345.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_32220"/>
    <dbReference type="EnsemblBacteria" id="AKH86117">
        <property type="protein sequence ID" value="AKH86117"/>
        <property type="gene ID" value="AA958_32220"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_32220"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6803"/>
    <dbReference type="OrthoDB" id="2038138at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNP_UDP_1" evidence="1">
        <location>
            <begin position="35"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="220" mass="22856" checksum="0416B6251CB4D9BA" modified="2015-07-22" version="1">MPDAPAPLLAVCALGIERRALASGTGRPEGAAGGAGPVHVLRTGMGPERAVRAVARRLAEEPYREAPVIAAGFCAGLLPDMRPGDVVVADAVRDGEGTETTGCPDNGPLFDALALLDARVHTGLLLGTDHVVRGAAGRAALRERGAVAADMESAATLRTAAATSGTRPVAAVRVVVDAPEHELVRFGTLRGGITAYRVLSSVLPAFFEWHRHVTIPRRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NHB7</accession>
    <name>A0A0F7NHB7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glutamate dehydrogenase</fullName>
            <ecNumber evidence="2">1.4.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_11240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + L-glutamate + NAD(+) = 2-oxoglutarate + H(+) + NADH + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15133"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.4.1.2"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="1.4.1.2" evidence="2"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_11240"/>
    <dbReference type="EnsemblBacteria" id="AKH86688">
        <property type="protein sequence ID" value="AKH86688"/>
        <property type="gene ID" value="AA958_11240"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_11240"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2368"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004352">
        <property type="term" value="F:glutamate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019551">
        <property type="term" value="P:glutamate catabolic process to 2-oxoglutarate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028971">
        <property type="entry name" value="NAD-GDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007780">
        <property type="entry name" value="NAD_Glu_DH_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43403">
        <property type="entry name" value="PTHR43403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05088">
        <property type="entry name" value="Bac_GDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036761">
        <property type="entry name" value="GDH_Mll4104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH86688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="1542" mass="171769" checksum="16263893B64E24D9" modified="2015-07-22" version="1">MIHPQIVVRRNVTGKLLEVLDAGRDPNASPPYARGLEDLPHDAVIESWIHVEIDRESDRADLKQITADLMRVLSDAREAVEDWQKMRDSALRIADDLDEEPLPDDMPTQEVEEARELLRWLAADHFTFLGYREYRLTVNSDGEELTAVPGTGLGILRADPSHAAFAKDDGKPQPASESFHRLPADVRAKAREHRMLVLTKANSRATVHRPAYLDYVGVKKFDAEGNVVGERRFLGLFSSAAYTESVRRVPVVRRKVAEVLSRAGFTPNSHDGRDLLQILETYPRDELFQIPVAELQSIVISVLYLQERRRLRLFLRQEEYGRYYSALVYLPRDRYTTSVRLRLVDILKEELGGTSVDFTAWNTESVLSRLHFVVRVDPGTGLRELTETDVHRIENRLADASRSWNDGFTEALVAEFGEERAAELAHRYAGAFPEGYKEDFAPRAAVSDLQHFEKLSSRGGTAEFALSLYEPVGAAPNERRLKVYGAGAPFSLTRVLPVLHNLGVEVTEERPYVLRCGGGLTDAWVSDFGLQFPPSQNGGGLEVGEDARERFQETFAAVWNGEAEDDGLNSLVPVAGLTWRQAMVLRAYARYLRQAGSKFSPAYMEDTLRTNVHTTRLLVSLFEARMAPERQHAGRELTDGILEELNGALDQVASLDEDRILRSFLTAIQATLRTNYFQHDGDGKSWHSYLSLKLDPQAIPGLPEPRPEYEIWVYSPRVEGVHLRFGKVARGGLRWSDRREDFRTEILGLVKAQEVKNTVIVPAGAKGGFVGKRLPDPSADRDAWLAEGIACYKTFIYGMLDITDNLVGGEVVHPKNVVRHDEDDTYLVVAADKGTATFSDIANEVAVSYDFWLGDAFASGGSAGYDHKGMGITARGAWESVKRHFRELGVDCQTEDFTAVGIGDMSGDVFGNGMLLSEHTRLIAAFDHRHIIIDPDPDPAVSYAERRRLFELPRSSWEDYDTRKLSDGGGVFSRKAKAIPVNAKMRRALGIRDGAAKMTPAELMKAILQAPVDLLWNGGIGTYVKSSAEAQADAGDRANDAIRVDGVDVRARIVGEGGNLGLTQLGRIEFARFGGPDGRGGKINTDAIDNSAGVDTSDHEVNIKILLNQVIGDGDMTVKQRNKLLGEMTDEVAALVLRNNYAQNTALANAVAQAPSLLQAHHRYMRKLGKEGALDRDLEFLPGEKQVRERLTAGLGLTQPELAVLLGYTKITAAEDLVATGLPDDPYLERLLFAYFPQPLRDRFPDQIRAHALRREIVTTVLVNDTVNTGGTTFVHRLKEETGASTEEIVRAHTAARAIFHLGDFWDEVETLDNVIAADVQTRIRLHSRRLVERATRWLLNNRPQPLQLSETIDFFSERIGQVWAALPKLLRGTDLEWYERNQNELTDNGVPAELAQRVATFSAAFPAMDIVAVADRARHEPLGVAEVYYDLGDRLHISNLMDRIVELPRADRWQSMARAAIREDLYAAHALLTAAVLSAEPEAEGEAITPELRFKTWEAKNAAILGRARSTLEEIQGSESFDLANLSVAMRTMRTLLRTNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NHG0</accession>
    <name>A0A0F7NHG0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pantothenate synthetase</fullName>
            <shortName evidence="5">PS</shortName>
            <ecNumber evidence="5">6.3.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Pantoate--beta-alanine ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Pantoate-activating enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">panC</name>
        <name evidence="7" type="ORF">AA958_18220</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>(R)-pantoate + ATP + beta-alanine = (R)-pantothenate + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10912"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
            <dbReference type="ChEBI" id="CHEBI:29032"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57966"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantothenate from (R)-pantoate and beta-alanine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="5">The reaction proceeds by a bi uni uni bi ping pong mechanism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the pantothenate synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.1" evidence="5"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_18220"/>
    <dbReference type="EnsemblBacteria" id="AKH86864">
        <property type="protein sequence ID" value="AKH86864"/>
        <property type="gene ID" value="AA958_18220"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_18220"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3831"/>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004592">
        <property type="term" value="F:pantoate-beta-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00560">
        <property type="entry name" value="PanC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00158">
        <property type="entry name" value="PanC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003721">
        <property type="entry name" value="Pantoate_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042176">
        <property type="entry name" value="Pantoate_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21299:SF1">
        <property type="entry name" value="PTHR21299:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02569">
        <property type="entry name" value="Pantoate_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00018">
        <property type="entry name" value="panC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 5" id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="228"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="8"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="1"/>
            <end position="8"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="35"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="122"/>
            <end position="125"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>(R)-pantoate</name>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="159"/>
            <end position="162"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH86864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="280" mass="29466" checksum="FAA81ACC26A6BB7C" modified="2015-07-22" version="1">MGALHEGHAALVRAARAEVGPHGQVVVTVFVNPLQFGPGEDLDRYPRTLDADVLLAGKEGADVVYAPSADEVYPGGEPHVRVSAGPMGERLEGAFRPGHFDGMLTVVAKLLHLTRPDVALYGQKDAQQLALITRMVRDLNFPVRILGVPTVREPDGLALSSRNVYLSAPERRTALALSCALFAARETAGAAGTPREALAAAESVLHDAGALTPPLELDYAALVDPADFTPVTDAGPRTPQDPDGTPRKDGPAREAVLAVAAKVGTTRLIDNIRLTFGGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NI67</accession>
    <name>A0A0F7NI67_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NPCBM_assoc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_00375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019672.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_00375"/>
    <dbReference type="EnsemblBacteria" id="AKH86462">
        <property type="protein sequence ID" value="AKH86462"/>
        <property type="gene ID" value="AA958_00375"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_00375"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.90"/>
    <dbReference type="OrthoDB" id="1217254at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018905">
        <property type="entry name" value="A-galactase_NEW3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10633">
        <property type="entry name" value="NPCBM_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NPCBM_assoc" evidence="1">
        <location>
            <begin position="34"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="310" mass="31497" checksum="36FA8F9D82879038" modified="2015-07-22" version="1">MLLPATVLAATARAAAAQTEITVSPIDLDGPAVTTVTVTVRNTAPQRLRDLRVSFSGPAGWVVEPEVRTVKSGIAPNAHATVTFELLVPAPSSGFQLLNFTATALYEGGDGLARATVTRTERRGEPLPTLAAAYNNVGITDESNTAPGDFDGGGNSFSAQKLADVGLSPGASVTALGAELTWPDVPPGAKDNVSSGGQAISLSGSGSKLVFLGSGVGNNAVGTARVFYTDGTSSSGSFGFPNWSFQNVTDHGATQIAASNGRNRQDGYGNAGVTYSIFAHSVPLQAGKTVDLVVLPGQGGIHIFAMAIAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NIF4</accession>
    <name>A0A0F7NIF4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyl-CoA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_04720</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_04720"/>
    <dbReference type="EnsemblBacteria" id="AKH86547">
        <property type="protein sequence ID" value="AKH86547"/>
        <property type="gene ID" value="AA958_04720"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_04720"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.995"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="2">
        <location>
            <begin position="6"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="3">
        <location>
            <begin position="409"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH86547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="491" mass="50240" checksum="3B922182BE73521C" modified="2015-07-22" version="1">MFPALRTAPERVALRFGGTVLTYGELAAAADGVARRLGGARRVAVWATPEPATAVAVTAALVAGIAVVPLNPRTGVRELAHIVTDSEPELVLAAPGAELPEALAGVARVDVAPGTPGSEPGSATPRPAPAPPGPGTPGLVVYTSGTTGPPKGVVLPQRALAATLDDLAEVWGWTERDTVVHALPLFHVHGLVLGVLGPLRRGGAVHHVGRFAPETVAAALAAGGTMLFGVPTMYHRLADALDAEPAAAPGAPSGTSLAAALAGARLLVSGSAALPVADHRRLTAATGRRVVERYGMTETLMNTSVSPGDPDATGSVGVPLPSVAARLVDDAGAELTAYDGETVGEIEVRGPSLFTGYLNRPEATAAAFRDGWFRTGDMAVRDAAGRFRIVGRRATDLIKSGGYKIGAGEIENALLEHPAVAEAAVTAEPDPDLGERIVAWVVPDGAAPPAAELSSYVADHLAPHKRPRKIHFLDALPRNDMGKVLKRALGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NII5</accession>
    <name>A0A0F7NII5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hydroxyurea phosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_28010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020473.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_28010"/>
    <dbReference type="EnsemblBacteria" id="AKH87078">
        <property type="protein sequence ID" value="AKH87078"/>
        <property type="gene ID" value="AA958_28010"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_28010"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5903"/>
    <dbReference type="OrthoDB" id="1457558at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006748">
        <property type="entry name" value="NH2Glyco/OHUrea_AB-resist_kin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04655">
        <property type="entry name" value="APH_6_hur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH87078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="296" mass="31809" checksum="1502FD30D78A45E2" modified="2015-07-22" version="1">MRVHASGRAWLAELPDLVEKMRARWSLRLGAPFRGGSCSWVAPARLPDGTDAVFKVTWPHREAAGEAEGLRIWDGRGAVRLLAHDPGHYALLLERCKPGTELGTAGELGAEHRLRLGAEVLRELWSAPVPQDCGLERVADVCAEWADLLEERMERLRPGYDAGLVAHGARLLRELPGGARREVVVHGDFNPGNILAAGRRPWLAIDAKPMTGDPGYDPFPLLEQIDDPFATADPARTVAARLALLAGELGEDTGRLAAWAVARRVEAALWSAEHGDVPGGAGVLGEARLLAEAAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NJ96</accession>
    <name>A0A0F7NJ96_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_17665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020174.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86852">
        <property type="protein sequence ID" value="AKH86852"/>
        <property type="gene ID" value="AA958_17665"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_17665"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3720"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="124" mass="12650" checksum="9B8C49B7DFEB6639" modified="2015-07-22" version="1">MLGSISMLGAGVAAADDTTEAAAPHGVTSTESTTAAPKSAPKGKHYDKGDEITTVVKCDQEIDNSVDRRQYGFLNIGDVTVPILGSGNADATANQNICGIGNDDNEAEAEAETENTTLLPGLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NJA2</accession>
    <name>A0A0F7NJA2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Amino acid ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_18170</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020187.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_18170"/>
    <dbReference type="EnsemblBacteria" id="AKH86862">
        <property type="protein sequence ID" value="AKH86862"/>
        <property type="gene ID" value="AA958_18170"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_18170"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3820"/>
    <dbReference type="OrthoDB" id="770506at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007210">
        <property type="entry name" value="ABC_Gly_betaine_transp_sub-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04069">
        <property type="entry name" value="OpuAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="OpuAC" evidence="3">
        <location>
            <begin position="34"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH86862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="312" mass="33055" checksum="EEAB7BF0E6574B41" modified="2015-07-22" version="1">MLAAAALTAGLAACGGDSLEEKGGTDSPDDDKSSLVVGQAGFTVSTVTAELYAAMLKDAGYDVTIKKLENRELYEPELEKGSIDVFPEYAATLAEFLNAKENGVEAPEKNPVASNDADETVTALRELAEPRGLKVLEAGDALDQNAFAVSKDFAAENDLKTLSDLGKTGDGIRLAAGDECPERPFCEPGLENTYDIDITKIDPLGVGTPAAKQSVQDGTNQLVLTTTTDATLDDFDLVLLEDDKGLQNADNILPVVNAKEAGTKEIAATLDKLTQVLTTEDLIELNRKVDAERMKPADAAQEYLEAKNLIGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MZ56</accession>
    <name>A0A0F7MZ56_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AA958_04480</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014925.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_04480"/>
    <dbReference type="EnsemblBacteria" id="AKH81570">
        <property type="protein sequence ID" value="AKH81570"/>
        <property type="gene ID" value="AA958_04480"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_04480"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.945"/>
    <dbReference type="OrthoDB" id="1101128at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="95"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="141"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="93"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="351"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="385"/>
            <end position="392"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AKH81570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="672" mass="71524" checksum="65B65711BAB19C8B" modified="2015-07-22" version="1">MLATLGGRQKLAERLSRPGLRLRGLSRLPWTSRISLGLLTLVVLVAVFAPLLAPHDPLDQQAQAGGTGHPSADHWMGQDSLGRDILSRLMYGARWSLIIGLGATLLALVAGAVLGAIAATSRKAVDEFVMRCLDIVMAFPGIALAAVLVAVFGGSIPVLVCAIAFLYVPPIARVVRANVLDQYGEDYVTAERVIGARTPHIIVKHVAINCAAPILVFCTVQVAEAIVFEASLSFIGAGVRPPDPSWGSVIADGKNMVLLGGWWATVFPGLLMLLTVLALNILSEGISDAWAAPASRRSESVVVKEAGAEDRIEAAAPGTGKVLELPGLTEAARRLRERARPLPGGEPVLAVRDLAIGFDQRHAGVDIVDGISFDVRPGEVLGLVGESGCGKSLTALTVMGLEPAGARVRGSVVFDGRELVGLPMRIRRKLLGHEMAMIYQDALSSLNPAMTIRAQLKQLIRRGGTRTATELLELVGLDPERTLRSYPHELSGGQRQRVLIAMALSRNPKLIVADEPTTALDVTVQAQVIELLLRLREELGFALILVSHDLALISDVTDRVVVMYGGQIVETGVTADLVEAPSHHYTRGLLGSVLSLESAQERLTQIRGVVPSPADFPAGCRFADRCPMASGRCLDTAPELVGEERKHEVACHHPAVEPAVAAVGEAEKEALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MZL8</accession>
    <name>A0A0F7MZL8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase</fullName>
            <ecNumber evidence="4">2.3.1.117</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Tetrahydrodipicolinate N-succinyltransferase</fullName>
            <shortName evidence="4">THDP succinyltransferase</shortName>
            <shortName evidence="4">THP succinyltransferase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Tetrahydropicolinate succinylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">dapD</name>
        <name evidence="6" type="ORF">AA958_05545</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2-amino-6-oxopimelate using succinyl-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(S)-2,3,4,5-tetrahydrodipicolinate + H2O + succinyl-CoA = (S)-2-succinylamino-6-oxoheptanedioate + CoA</text>
            <dbReference type="Rhea" id="RHEA:17325"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15685"/>
            <dbReference type="ChEBI" id="CHEBI:16845"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="EC" id="2.3.1.117"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (succinylase route): step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the type 2 tetrahydrodipicolinate N-succinyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.117" evidence="4"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015104.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_05545"/>
    <dbReference type="EnsemblBacteria" id="AKH81750">
        <property type="protein sequence ID" value="AKH81750"/>
        <property type="gene ID" value="AA958_05545"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_05545"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1162"/>
    <dbReference type="OrthoDB" id="1251912at2"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00019"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008666">
        <property type="term" value="F:2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02122">
        <property type="entry name" value="DapD_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019875">
        <property type="entry name" value="DapD_actinobacteria"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032784">
        <property type="entry name" value="THDPS_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038361">
        <property type="entry name" value="THDPS_M_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026586">
        <property type="entry name" value="Type2_DapD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14602">
        <property type="entry name" value="Hexapep_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14789">
        <property type="entry name" value="THDPS_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03535">
        <property type="entry name" value="DapD_actino"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="4" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="THDPS_M" evidence="5">
        <location>
            <begin position="123"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Succinyl-CoA binding" evidence="4">
        <location>
            <begin position="270"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-anhydride intermediate" evidence="4">
        <location>
            <position position="212"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>ligand shared between trimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>ligand shared between trimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>succinyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>succinyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>succinyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>succinyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>succinyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>succinyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH81750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="331" mass="33938" checksum="1F02C9BD712A7040" modified="2015-07-22" version="1">MTDAATTTTLPTGAAATGLATVTPDGTVLDTWFPAPALADDPGPAGTERLTAERAAELLGEHARAALGPDPLRGVEVVAVRTVISSLQEKPADAHDVYLRLHLLSHRLVRPHGQNLDGVFGLLANVAWTSHGPVPADRIEEVRLAVRAAGQHLQVSHLDKFPRMVDYVLPSGVRIGDADRVRLGAHLAAGTTVMHEGFVNFNAGTLGTSMVEGRISAGVVVGDGSDVGGGASIMGTLSGGGKDVISLGERCLLGAQAGIGISLGDDCIVEAGLYVTAGTKVGLPDGTVVKARELSGASNLLFLRNSTTGAVEARQRLGSWGGLNAALHAND</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0H7</accession>
    <name>A0A0F7N0H7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_00165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH80844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014211.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH80844">
        <property type="protein sequence ID" value="AKH80844"/>
        <property type="gene ID" value="AA958_00165"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_00165"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.37"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH80844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="431" mass="48135" checksum="66F5250EFCEEDFA6" modified="2015-07-22" version="1">MGVYVANIEQKDDGRWEAAADGLVATGDGYTAARHALSDALFARDGQEPTIRRDRTEVAIPGRQERTPERLTALIAAEVPDHVEKAAHSLAEARERDAREESTSAVTAWCVHTAGIIVISRACPSQNRGEPSFVPRAKPDPRAGDDVFLACWMPHEVDDLDELKKVADVPRTVMGILEALDPYLRAQAWQDMTRATHGPALDRAMARWWHAAVVMGTAATERTVRQATQRLAAGQHGTPITDLPASRARDDLDHDLTDAEKAADRHERDRQRQQDEATRRAREDAYLDDIERLLAAERQRFDAQHQNERQRLTVLAARSGIDRPAREYPIGTAHFTLLRDGRPITMHLPARPWRRVTSREPGEPYHFLLTSEDGAQLAHVTHVRTYDSIEAFDRAGEKTTAADVVAPSRRELASYPTSVLSREFAGGCRVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0W0</accession>
    <name>A0A0F7N0W0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_01125</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH80999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014364.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_01125"/>
    <dbReference type="EnsemblBacteria" id="AKH80999">
        <property type="protein sequence ID" value="AKH80999"/>
        <property type="gene ID" value="AA958_01125"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_01125"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.248"/>
    <dbReference type="OrthoDB" id="520320at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010281">
        <property type="entry name" value="DUF885"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33361">
        <property type="entry name" value="PTHR33361"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05960">
        <property type="entry name" value="DUF885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH80999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="561" mass="61704" checksum="AD865D1ABB4B747E" modified="2015-07-22" version="1">MPDSTNQRMPRQVADAYVDDLIDLDPISGTMLGVPESSRTLPDFSPDGQQAVAELGRATLAALDEAERQPGADSDAERRCARLLRERLSAELAVHDADEGLRAVSNIHSPVHLMRECFTLMPTAGEDDWSDIAARLRAVPAALDGYRRSLAAGVDKGLFGGPRATATFVGQLTEWSGGERGWFGDLTAAGPESLRGELDAAAGEATAAVSALRDWMRDVYAPAAAGSPDVVGRERYARWSRFFNGADLDLDESYAYGWSEYHRLLGEMKTEAAKILPGAATPWEALKHLDEHGTHIEGEDAVREWLQGIMDEAIEALDGTHFDLAGPVRRVESRIAPPGGAAAPYYTPPAEDFSRPGRTWLPTMGETRFPVYDLVSTWYHEGVPGHHLQLAQWVYVKDRLSRYQSTLGWVSANCEGWALYAERLMDELGFLTDAEQRLGYLDAQMMRSTRVIVDIGMHLELPIPDHSPFHPGERWTPALAQEFFGMHSGRPADFVESELTRYLSMPGQAIGYKIGERAWLRGRDAARKARGADFDAKAWHMAALSQGSLGLDDLEAELSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N129</accession>
    <name>A0A0F7N129_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NUDIX hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_01790</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014472.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_01790"/>
    <dbReference type="EnsemblBacteria" id="AKH81108">
        <property type="protein sequence ID" value="AKH81108"/>
        <property type="gene ID" value="AA958_01790"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_01790"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.390"/>
    <dbReference type="OrthoDB" id="1308416at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="19"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH81108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="162" mass="17527" checksum="75C9ED48EC2BCAD4" modified="2015-07-22" version="1">MATPDFIRELRATAGQQLLLLPGISAVVVDDGRVLLHRRADTGRWSIIGGIPEPGEQPAQTAVREVREETGVVCTVERVVGVEALDPIQYPNGDKCQFMDITLRCRATGGEARVNDDEGLEVGWFAPDALPPDLEDFARHRIRLALADGPTWFAEAAATPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N160</accession>
    <name>A0A0F7N160_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycosyl hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_05520</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_05520"/>
    <dbReference type="EnsemblBacteria" id="AKH81746">
        <property type="protein sequence ID" value="AKH81746"/>
        <property type="gene ID" value="AA958_05520"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_05520"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1157"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006584">
        <property type="entry name" value="Cellulose-bd_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005084">
        <property type="entry name" value="CMB_fam6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012938">
        <property type="entry name" value="Glc/Sorbosone_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022409">
        <property type="entry name" value="PKD/Chitinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000601">
        <property type="entry name" value="PKD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035986">
        <property type="entry name" value="PKD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011041">
        <property type="entry name" value="Quinoprot_gluc/sorb_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03422">
        <property type="entry name" value="CBM_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07995">
        <property type="entry name" value="GSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00606">
        <property type="entry name" value="CBD_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00089">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49299">
        <property type="entry name" value="SSF49299"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50952">
        <property type="entry name" value="SSF50952"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51175">
        <property type="entry name" value="CBM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50093">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519672" evidence="3">
        <location>
            <begin position="31"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="4">
        <location>
            <begin position="501"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="domain" description="CBM6" evidence="5">
        <location>
            <begin position="696"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="208"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH81746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="817" mass="85662" checksum="98518AB8C08A2D9A" modified="2015-07-22" version="1">MHKTRPRLRTALAAFAGALLLGSGLAPGMAATGAAHEPPAAAQDGPAAPDLQQVTLAKGVDQVGEPMALAVLPDGAVLHTSRDGTLWHTGAAGGTRVAAQLPVYPHDEDGLQGVGVDPDFETNRAVYLYYAPVTDTPHGIAPSDGTPAEFEAYEGVNRLSRFTLNQDGTLDLGSEQTVLEVGTDRGRCCHNGGDIAFDSEGNLLLSTGDDTDPFSSDGYTPIDERETRNPSFDGQRSAGNTDDLRGKILRIKVDPADGSYTVPDGNLFAPGTEKTRPEIYAMGFRNPFRMSVDKATDTVYVGDYGPDSGAADPARGPGGQVEFNRITEAGNFGWPYCHGANDAYIDYDFATGASGEAFDCAAPRNESPRNTGLTELPPAQSAWIAYDGNSVPEFGSGSESPMAGPVFRHDPDLGSRLQLPERYDELFFAGEHGREWIKTIGVGADGGVGAIEDFSSGSKIMDMEFGPDGALYFLDYGTGFFNGDQNSALYRIQNAAQGFAPEPVASSGATTGHAPLKVAFSSAGTADRDSEQLRYRWDFGDGKTSDKRNPQHIYSRDGQYSAVLTVTDPDGNTGTSAVRVVVGNTPPEVELKLPADGTVFEYGDDIPFEVAVTDAEDGEIDCSRVRVDYALGHDTHGHPMTFEEGCTGTIETFEEDRHDDNANLFGLIRARYTDGGGATAGVPALNSSAEHKLQPAHRQAEHFDTADGATAGAASGAEGGRAVTGGGGEWIAFEPYVLDGITRLSARVDAAGSADGAVELRAGAPDGPVLATAPVGGESGWHEAGAAVKDPPAGTTSLYLVLTGGEFTLDSFHLGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N179</accession>
    <name>A0A0F7N179_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_01945</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014498.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_01945"/>
    <dbReference type="EnsemblBacteria" id="AKH81134">
        <property type="protein sequence ID" value="AKH81134"/>
        <property type="gene ID" value="AA958_01945"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_01945"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.420"/>
    <dbReference type="OrthoDB" id="1944211at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002518953" evidence="3">
        <location>
            <begin position="28"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH81134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="217" mass="21389" checksum="7375512C0079CBC9" modified="2015-07-22" version="1">MRIISTALAAAAVGAVAAGLTATVATAQGNDGNITSFGFTVTPKTVKPGGRVELTVTDCDKEATASSAVFDKTALGTGGGTQSAQAMVDLDAKPGASFEVTFTCGAESGTAPLTIAGAGGGKSETGSTSRPREEQGKEATRTALPARPGKEGAEPAEPGKEAVRPAEPVKPVKPARGGLGGSQEDHVVMLSGGAGLTAAGAFGGALLLRRRETPGRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N182</accession>
    <name>A0A0F7N182_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_02150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014532.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH81168">
        <property type="protein sequence ID" value="AKH81168"/>
        <property type="gene ID" value="AA958_02150"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_02150"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.463"/>
    <dbReference type="OrthoDB" id="1825123at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="295" mass="31804" checksum="C866580CE7A815D7" modified="2015-07-22" version="1">MKYAGYVFGGLSGAAAGGYFVLYLYRWEWQRALISGVLLLAVEVLLVGIVLHARVSRLRREVAEGRDRTEEILRGLERTRPDPSPRFRWLEARRRDGTHRTYVFVPVLMAAGAVMSAAAWAVQKLASAAGGPGDRRTAARLAGLAAPPGGVGRAEPLESRPAVRRPPRVRTFVVAVLALTALAFGVGRLADATQTRPRERPTAAATTVVFEVAVRGSADAAAGRMAARDLWESCRRATRVPARHAPLSRLEGDLWVGSVRPALGDHDRMRLRGCLDDATAERTTAKVLGDGQVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N1I3</accession>
    <name>A0A0F7N1I3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">XRE family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_02975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_02975"/>
    <dbReference type="EnsemblBacteria" id="AKH81308">
        <property type="protein sequence ID" value="AKH81308"/>
        <property type="gene ID" value="AA958_02975"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_02975"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.635"/>
    <dbReference type="OrthoDB" id="824224at2"/>
    <dbReference type="Proteomes" id="UP000034283">
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    </dbReference>
    <dbReference type="GO" id="GO:0003677">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
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        <property type="entry name" value="DUF5753"/>
    </dbReference>
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        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="19"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="286" mass="32529" checksum="2F58BC25AAC81639" modified="2015-07-22" version="1">MSEPRSAPTVGQVVLGKRLQELRERAGLKREEAAKTLRVAPATVRRMETAEVALKVPYVQLLLQAYGIDQEEIDAFVALTEEANEPGWWQRFHDILPDWFSMYVSLEGAASLIRSYEPHFVPGLMQTEDYARHVLKVGSLGRVAPAEIERHVALRMERQELLTREDAPRFWVIVDETVLRRPVGEAAVMRAQVDRLLDIASLPNVTLQMAEFRTGHHPGTYSPFVLFRFAMPELPDMIYTEYLTGAVYLDGRHEVATHLAALDHMAAQAATAKRTKEILRDFRKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N1I4</accession>
    <name>A0A0F7N1I4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pyridoxamine 5'-phosphate oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_06090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015199.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_06090"/>
    <dbReference type="EnsemblBacteria" id="AKH81846">
        <property type="protein sequence ID" value="AKH81846"/>
        <property type="gene ID" value="AA958_06090"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_06090"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1272"/>
    <dbReference type="OrthoDB" id="1804797at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019920">
        <property type="entry name" value="F420-binding_dom_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03618">
        <property type="entry name" value="Rv1155_F420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="1">
        <location>
            <begin position="18"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="156" mass="17222" checksum="AF7EFF369DE0F1AC" modified="2015-07-22" version="1">MSPNIATNTRVDLAGLLDFVRPRHRALLLTRRADGSPQASPLTCGVDDAGRIVVSTYPERAKTRNARRDPRVGIVVLSDEWDGPWVQVDGAAEVIDATADVEPFVEYFRNIAGEHPDWDEYREAMVRQGKSLIRITPERWGPVATGGFPARLSEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N1L3</accession>
    <name>A0A0F7N1L3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">2-dehydropantoate 2-reductase</fullName>
            <ecNumber evidence="2">1.1.1.169</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Ketopantoate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_06305</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>(R)-pantoate + NADP(+) = 2-dehydropantoate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:16233"/>
            <dbReference type="ChEBI" id="CHEBI:11561"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.169"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantoate from 3-methyl-2-oxobutanoate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the ketopantoate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.169" evidence="2"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018835555.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_06305"/>
    <dbReference type="EnsemblBacteria" id="AKH81881">
        <property type="protein sequence ID" value="AKH81881"/>
        <property type="gene ID" value="AA958_06305"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_06305"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1317"/>
    <dbReference type="OrthoDB" id="427052at2"/>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00004"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008677">
        <property type="term" value="F:2-dehydropantoate 2-reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003710">
        <property type="entry name" value="ApbA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013752">
        <property type="entry name" value="KPA_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013332">
        <property type="entry name" value="KPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02558">
        <property type="entry name" value="ApbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08546">
        <property type="entry name" value="ApbA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00745">
        <property type="entry name" value="apbA_panE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ApbA" evidence="3">
        <location>
            <begin position="4"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="ApbA_C" evidence="4">
        <location>
            <begin position="179"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH81881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="296" mass="30184" checksum="73F1B9DCB83A618B" modified="2015-07-22" version="1">MNAAVLGPGGVGGLLAGLLARAGHRVTCLAGDATAGALQADGITVNSKQFGDFATHVAGDTELREPVDLCVVAVKATAFDAALERVPPAALGDGLVVPLLNGVDHMAALRERYRPEQVAAGTITVESTRIAPGLIEHGSPFTKVSLASATAPRARLEAVARVLTDAGAEVQVRDDEASVLWTKMAFLAPMALLTTRHGLPVGGVRTEHRDEMLALLAETAAVASACGARVDAAAVATMYDTFPARTKSSMLRDAEAGRPLELDAIGGALLRAAGAHGIAVPVAERLVAEIGARAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N245</accession>
    <name>A0A0F7N245_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycosyl hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_00785</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH80942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AKH80942">
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        <property type="gene ID" value="AA958_00785"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_00785"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.177"/>
    <dbReference type="OrthoDB" id="166825at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031924">
        <property type="entry name" value="GH115"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041437">
        <property type="entry name" value="GH115_C"/>
    </dbReference>
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        <property type="entry name" value="GH115_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17829">
        <property type="entry name" value="GH115_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15979">
        <property type="entry name" value="Glyco_hydro_115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 5" id="KW-0378">Hydrolase</keyword>
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    <feature type="domain" description="GH115_C" evidence="4">
        <location>
            <begin position="893"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="630"/>
            <end position="657"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH80942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="1070" mass="116456" checksum="9F04C8BF8C6752C6" modified="2015-07-22" version="1">MDSSDSRHDPSPASDFPPGDGVSRRRVLGAGLGLGALSASAGGVLGLPGPAAAAPAQDPPRPTDPGAYIAHGPGADRFPLVAGGRAAPLVADGGDFPGVLRALGDLRADLERVTGVRPALTRGRAPSGRTAVLVGTIGRSPLIDGLIAAGKLDVSGIEGRWETSLHQVVADPLPGLDSAFVIAGSDQRGTIFGIYDVSRGIGVSPWHFWADVPPRRHDALYVLPGRFSQGTPAVRYRGIFINDENPALGRWAPGFFGPGHAEGHPGGFNSAFFAKVFEAMLRLKANYLWPAVWGRAFAEDDPVNHATATEYGIVMGTSHEAPMMRGIEEWNRHAVPAVRDANGNIVTEGHDPYGGTGEWSFVRNEAAIRAYWRDGIRRMAAEGFEGVVTLGMRGNGDTSLPDGDGIELMERIIATERGILAEELGDAATVPQVWTMSKEVQHYWDSGMQAPDDVTVVFTDDNWGNLRRVPDPSLPPRSGGYGLYYHFDYVGGGRNYKWVDTANLASTWEQLHQTYAYGIRNLWVANVGDLKSNELPTQFFLDYAWNPDRWPADALPEWERRYAAENFGPRHAAEIAEILHEYGRLQARRKPELLNRRITLDPARDPATDPAAVVYDDQATPFSRVNYGELDRVTDEWQELARRADRVEARLDRADRAAYFQLVRYAVRGTAVVYALRRAEFTNLLYAAQGRAAANQLAAETDALFAEDQALADYYNHTLSGGKWQGFQTQPKIGYGDVERYGPNAPWQQPEKDDEALPDEVFPAVRRIDPVAGALLGVAVEGSEQWWPDAAGPAVLPEVSPYDSGTAPYIEVFNRGRSPFGYEIEPAVPWLRVDRPRGRVTSQIRATLRVDFARAPRGTTTVPIVVSGAGRTVEVHARVHRPSVRHSALAGSVEAGGCVSVEADRHTRAVPAAGVAWRRIPGIGRTGNGMAPFPVTASPRPAGQGPRLEYTMTLFTTGTLRVAAYLSPRNSVLTPDGLRYAAAFDDDAPQTVNVTRVTGADDGRMNRQWERNTSDNATVTVTEHRVTRPGVHVLKLWMVDPTVVVQKLVVDTGGVRHSYLGPPPSTFVQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N252</accession>
    <name>A0A0F7N252_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">LacI family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_11065</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016018.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_11065"/>
    <dbReference type="EnsemblBacteria" id="AKH82680">
        <property type="protein sequence ID" value="AKH82680"/>
        <property type="gene ID" value="AA958_11065"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_11065"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2330"/>
    <dbReference type="OrthoDB" id="1796334at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Peripla_BP_I"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="5">
        <location>
            <begin position="2"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="313"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH82680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="335" mass="35793" checksum="98407D0D07F5461C" modified="2015-07-22" version="1">MVKITDVARHAGVSPSTVSYALSGKRPISEETRQRIESSIRELGYRPHAGARALASSRSNVLALVVPFRSGIHVPVVMQFAVSVVTTARQHDHDVLLLTQEEGEEGLRRVADTALVDALIVMDVQLHDARLPLLRALDRPSVLIGFPADAAGLTCIDLDFAAAGGACVTHLAELGHRCVALVGSPPEVYLRQTGFAQRVTQGFTAAADERGLASTVHPCEATPAAAQAMAEQLLREHPELTGVVVHNEPVVQPLIEAFRRLGLRVPEDLSVVAICPDELAEQAPVPISSVAVPSAEIGTRAVELLMRKLDQPDVPESTLLPPRLTRRATTAPRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2H8</accession>
    <name>A0A0F7N2H8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4397 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_04580</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014943.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH81588">
        <property type="protein sequence ID" value="AKH81588"/>
        <property type="gene ID" value="AA958_04580"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_04580"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.966"/>
    <dbReference type="OrthoDB" id="1752332at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025510">
        <property type="entry name" value="DUF4397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14344">
        <property type="entry name" value="DUF4397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519178" description="DUF4397 domain-containing protein" evidence="2">
        <location>
            <begin position="30"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4397" evidence="3">
        <location>
            <begin position="38"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH81588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="278" mass="27947" checksum="60ACCB44EC568B7D" modified="2015-07-22" version="1">MKNSRSRKTAAAAAGACILSLAVAVPASAEGTAQKDTEVSVFHGVPGLTVDVFANGDELVPDFKPGTLTEPQPLAPGTYDIEVFPDGEGPDGEPAIQKSIEVPAGANATIAAHLNAQGDPTLTAFVNDTSKVPAGESRLTVRHVAAAPAVDVRADGKPVIEGLTNPNEKSLKVPAGTVSADVVLAGTDTVAIGPADLNLAEGTNTIVYAWGSAEDDNLALKTQTISGVDSAPRGASAGESGAMAGDNESAAVWFASGTTGAVAVAGLLASRRRRSRSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3E9</accession>
    <name>A0A0F7N3E9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_06435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015257.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH81904">
        <property type="protein sequence ID" value="AKH81904"/>
        <property type="gene ID" value="AA958_06435"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_06435"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1344"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="61" mass="6821" checksum="876FCC9F2AB63307" modified="2015-07-22" version="1">MGKRKNREKQQQQHSHRDKYAGSPAGIPDRGRRQSFDEPPPETRAQAPAGDAGTRPRAGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3N4</accession>
    <name>A0A0F7N3N4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_03735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014805.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_03735"/>
    <dbReference type="EnsemblBacteria" id="AKH81447">
        <property type="protein sequence ID" value="AKH81447"/>
        <property type="gene ID" value="AA958_03735"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_03735"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.786"/>
    <dbReference type="OrthoDB" id="1759826at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005537">
        <property type="entry name" value="RAMP_III_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03787">
        <property type="entry name" value="RAMPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="470" mass="49626" checksum="B183A0A46CCCA1B7" modified="2015-07-22" version="1">MNVVIHLLRAELEFTSPGGVAAPESLTAGSVLTPDLPVARDGDGLPYVPGSSVAGALRGAVAEEAGKVRLFGEVRKEQLDDGSDRTTAVASPVRVLGTRLVPPEDGPPKPAVRRRTAIDRHRAAAEANTLHEREVVPPGTRLTVWLRLDAAAEDSDRLDELLALLRTWRPCFGGGRTTGLGQARLLSVHHRPIDLNTPEGLRHWLLGGGPGLVDDLAELLYDAGRPGAARSAPEIPLAFGRELHFGIVDAIHLGTGEHRERGHGRTGYAPVLLDHEDAPVIPGTSWKGLLRARVEFILRSAGIDTCASAGGGAGDGTCGECATCAEFGFSGRRKHGGEPAGEAGSVGARGTLIFNDSAIRNGRRRRRNHVALDRVFGGARDNLLFTEEVVEDGTLTLRVQSTGDLSDPVRAALVLALYDIHDGRTGIGGGTTRGLGTLTAIEDTARWLESERTAAMAALSAHVPQEVPAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4F6</accession>
    <name>A0A0F7N4F6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cobalt ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_12160</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016201.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_12160"/>
    <dbReference type="EnsemblBacteria" id="AKH82866">
        <property type="protein sequence ID" value="AKH82866"/>
        <property type="gene ID" value="AA958_12160"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_12160"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2558"/>
    <dbReference type="OrthoDB" id="1479665at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006824">
        <property type="term" value="P:cobalt ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003339">
        <property type="entry name" value="ABC/ECF_trnsptr_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012809">
        <property type="entry name" value="ECF_CbiQ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02361">
        <property type="entry name" value="CbiQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02454">
        <property type="entry name" value="ECF_T_CbiQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH82866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="254" mass="27430" checksum="614B11BE3A4AC8E5" modified="2015-07-22" version="1">MGAGHAHKLYRHGDSPVHRLPAHVKVVAAFSFVLITVATPREAVWAFGAYALLLTGVAAAAHVPAGFVLRRLVVEVPFVAFAVLLPFVAEGPHTEVLGLSLSESGLWGAWNVLVKGTLGVATSVLLAATTELRALLLGLQRLRMPPLLVQIASFMVRYGDLITDDMRRMRIAREARGFTARGPRHWGVLARTAGALFIRSYERGERVHLAMVSRGYAGTMPVVDEVRATQGQWSYAAALPLAALAVCLLGWILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4G2</accession>
    <name>A0A0F7N4G2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_05500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015096.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_05500"/>
    <dbReference type="EnsemblBacteria" id="AKH81742">
        <property type="protein sequence ID" value="AKH81742"/>
        <property type="gene ID" value="AA958_05500"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_05500"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1153"/>
    <dbReference type="OrthoDB" id="1826886at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="12"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH81742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="200" mass="21692" checksum="7FE0F6C17449DC75" modified="2015-07-22" version="1">MATQTPVQPRLTPAARKILDAAETLFYNRGITAVGVDLIARRAGVTKKTIYDRYGSKDALVAAYLRRRDERWRTWLPAEVERTAAGGTACDRILATFDALGTWMGGQSPRGCSFVNAAAELTDPGHAGRQVIADQKHWLRGYLRELCERAGAEDTGLLADELLLIHEGATVLYGLSAVPEPVTVSRRLAEAALLRAGCTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N502</accession>
    <name>A0A0F7N502_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glucanase</fullName>
            <ecNumber evidence="8">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AA958_06310</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the glycosyl hydrolase family 6.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="8"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015235.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_06310"/>
    <dbReference type="EnsemblBacteria" id="AKH81882">
        <property type="protein sequence ID" value="AKH81882"/>
        <property type="gene ID" value="AA958_06310"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_06310"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1318"/>
    <dbReference type="OrthoDB" id="1331351at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016288">
        <property type="entry name" value="Beta_cellobiohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036434">
        <property type="entry name" value="Beta_cellobiohydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001524">
        <property type="entry name" value="Glyco_hydro_6_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34876">
        <property type="entry name" value="PTHR34876"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01341">
        <property type="entry name" value="Glyco_hydro_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001100">
        <property type="entry name" value="Beta_cellobiohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00733">
        <property type="entry name" value="GLHYDRLASE6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51989">
        <property type="entry name" value="SSF51989"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00655">
        <property type="entry name" value="GLYCOSYL_HYDROL_F6_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2 8" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="4 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 8 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005117481" description="Glucanase" evidence="8">
        <location>
            <begin position="35"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="390"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001100-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AKH81882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="456" mass="48229" checksum="9CDA96D8CF883905" modified="2015-07-22" version="1">MRKSRLRVTGVSAAALAATGTLLTYSLSAPPAAAETAAPGDNPYAGSQLYVNPDWSAAATQGGGAAIADTPTAVWLDSIAAITSGSDGSNTMGLREHMDEALAQGADAIQIVTYNLPGRDCAALASRGELGPTEIDRYKNEFIDPIDEILDDPAYESLKIINVVEIDSLPNLVTNVSGRPTGTPECDVMKANGNYVKGVGYNLATLGDNGNVYNYIDIGHHGWIGWDDNFQPTADLLYQAANAEGATPEDVTGFAANTANYGATEEPYFSIDDVAGDGPIREGHSSWVDWNRYVDEQSFAQAFVTKAAPAAGFPSGMGAIIDTSRNGWGGADRPTGPGDISGPGEEYVNDSRTDRRIHLGNWCNQSGAGLGERPTVSPAANIHAYAWIKPPGESDGASEEIPDDDKGFDRMCDPTYEGNERNQYNMSGALPDAPTSGHWFQAQFEELIANANPPVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N528</accession>
    <name>A0A0F7N528_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_09840</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015826.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_09840"/>
    <dbReference type="EnsemblBacteria" id="AKH82484">
        <property type="protein sequence ID" value="AKH82484"/>
        <property type="gene ID" value="AA958_09840"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_09840"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2073"/>
    <dbReference type="OrthoDB" id="1688736at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="282"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="77"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH82484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="315" mass="34665" checksum="E6B5EE5063252092" modified="2015-07-22" version="1">MAAAVHTLGARRRRAALRTLGFLSPWLVGFGVFFAYPLGATVYFSFMKYDGFTDPVWVGLKNWRYVLFDYPFFWPALANTLWLVAVMVTLRTVFGLGIGLLITRIKTGAGVFRTLFYLPYLAPPVAATMSFVFLMNPGTGPVNTVLGRLGLGEPGWFNDAQWSKPALTVLALWCVGDLMVIFMASLLDVPKEQYEAAELDGAGAWSRFRYVTLPNIRPVVLFAVVTGVIATMQYYTEPIVAAKVASGVIGGSGQHFEPGYPEKSTLTVPQSVYHLGFQRFDTGAACVVALVLFVLAMAFTYVLMRRGSGFLKEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N549</accession>
    <name>A0A0F7N549_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zinc metalloprotease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">AA958_10150</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CNQ-509</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8 10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8 10">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the peptidase M50B family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015870.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH82528">
        <property type="protein sequence ID" value="AKH82528"/>
        <property type="gene ID" value="AA958_10150"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_10150"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2137"/>
    <dbReference type="OrthoDB" id="1401629at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008915">
        <property type="entry name" value="Peptidase_M50"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016483">
        <property type="entry name" value="UCP006404_Pept_M50_CBS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02163">
        <property type="entry name" value="Peptidase_M50"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006404">
        <property type="entry name" value="UCP006404_Pept_M50_CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0129">CBS domain</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="8" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8 10" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="107"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="186"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="215"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="12">
        <location>
            <begin position="252"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="12">
        <location>
            <begin position="314"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR006404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR006404-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR006404-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AKH82528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="379" mass="40018" checksum="A4D82BA006B79564" modified="2015-07-22" version="1">MRATFTLGRIAGIRVGVHWSVVLIFGIILVGLAQGQLPDSDPGRPRALYWAAGLVAALVFFVSLLAHELAHAVVARRNGVDADDIVLWLLGGVARLKSEASSPGAELRIAGIGPLVSLVLGGLFVLGTWLLHHASAPELVVQVMGWLAGINLLLAVFNSLPAAPLDGGRLLRALLWWRTGDRLRAIAGATAAGRALGWLLIVLGFVWFLRGGGFSGLWLALIGWFLIGAATAESRQAQLRGVLSGVPVRNAMTPDPVVVPASLDVAHLLDNPLYRHSAFPVLGGNGEPVGLVTLRGARHVRPDHGGTVTVGEVMVPLAELVVVGPDDSLADLLPRMSPGPEHRVLVTEEGRLAGILSLSDISRTVRYLAETTPRARQGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5C7</accession>
    <name>A0A0F7N5C7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">IclR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_10595</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AKH82599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_10595"/>
    <dbReference type="EnsemblBacteria" id="AKH82599">
        <property type="protein sequence ID" value="AKH82599"/>
        <property type="gene ID" value="AA958_10595"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_10595"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2230"/>
    <dbReference type="OrthoDB" id="370329at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="SMART" id="SM00346">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="4">
        <location>
            <begin position="27"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="5">
        <location>
            <begin position="90"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH82599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="269" mass="29178" checksum="5DF5EC777E2041CB" modified="2015-07-22" version="1">MPVLHPPPGDQPPGRRPEPRDEPAAPFPSVRHALRVLESAARHGGEGVPVARLARETGLPPGQLAHLLLTLRRQRYLERLEDGSYAIGEAVALLGAGGSRTRAVHDKLRREMNELRKTTRAAIYLGRYEDGEVRVTQIADAPGTPRVNEWVDFRSAAHATALGKCLLTQLDHDARRDHLSRHRAARLTSRTITGEAAVLAALDRQVATVPTLDLQEYAVGTVCAAVPLTAGLEIGCVALSLPVNQTHRLRAAAERLNREAANLLLALSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5K2</accession>
    <name>A0A0F7N5K2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_18390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017148.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AKH83850">
        <property type="protein sequence ID" value="AKH83850"/>
        <property type="gene ID" value="AA958_18390"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_18390"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3861"/>
    <dbReference type="OrthoDB" id="1871268at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="229"/>
            <end position="251"/>
        </location>
    </feature>
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        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH83850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="491" mass="51353" checksum="7117899E1B96B4AE" modified="2015-07-22" version="1">MGTWLRRRPEIVAAVLVAVLVAVVAGQRYGFRSTTPAGARPEPGPSAAHPPTEADLRLRVERVGAGLAREPLYADPESERVLEAAERGELLDRIRGFDHGVFVAIVPTQREDESGGDAVELMRRLHEQLDRDGVYVVADPYVGDIEVANHATLLDSDHLEDELPREVMRADVDSDVDDLRLPERLGTLMTLLEEAPRNSTPGEPPYQLPADEEEEYEPEPLPSVFGADFGPGLGVGAFLALVLFGLVVAACTPMRARRRHRAAMWVPLPAQLPAGRPGALAVTAPGADGFRAPGRAELHRAADEALRSLAQRYAAVADGPGKAAGVPGGHGGLPDGPGVIRAADCLDAALLVVDGRQDGHVDRDAAPEALVCALVLARAGHAALGGAPHAAADYRCCATNPLHGPEAAAPDFAPGPAPGSAPGPVPGHAPGPVPLCTACRHAAAPPHVMRLQLPTPHGPLPYDSVPGPLAAAATGITELIRQVREYAGVPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5M7</accession>
    <name>A0A0F7N5M7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">D-glucose O-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_07650</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015477.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH82127">
        <property type="protein sequence ID" value="AKH82127"/>
        <property type="gene ID" value="AA958_07650"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_07650"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1608"/>
    <dbReference type="OrthoDB" id="1518440at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020803">
        <property type="entry name" value="PKS_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00828">
        <property type="entry name" value="PKS_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_MT" evidence="2">
        <location>
            <begin position="15"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH82127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="277" mass="30203" checksum="90DAD8B3911FFF16" modified="2015-07-22" version="1">MARRPERTEESDDKFFDTLTGILAEAYGSHLHFGYWDASGDGSLAAATSCMTDQVIKRTRVRAGQRVLDIGCGTGAPALRLAHVCGVEVVGVSVSAREVDRANERSRREGLAHRVRFESADAMSLPYADGSFDAVWAIESMSHMPDRGRVFCEIGRVLAPGGRLVIADGYHRGAGPEASSALMDTMCTAFRMHSPPTLTGYEDLFTAAGLRTLESLDLSDHAWRSIGYLTETLRTRSPEFAHVLGEAAFTHLMECLKEADAAEIFGYVLLTAERRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5N2</accession>
    <name>A0A0F7N5N2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_18675</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017187.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_18675"/>
    <dbReference type="EnsemblBacteria" id="AKH83890">
        <property type="protein sequence ID" value="AKH83890"/>
        <property type="gene ID" value="AA958_18675"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_18675"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3916"/>
    <dbReference type="OrthoDB" id="764005at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Metallophos" evidence="3">
        <location>
            <begin position="288"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="523"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH83890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="546" mass="57688" checksum="2696A09B58019FBC" modified="2015-07-22" version="1">MAREVPFAVSPVRALFERLRRAPARVRRFPAAVRRLADRARGARPARPPRAPRRRRVESSLVQRPHPYARALGLAAVTVVGAGLGLLVVGGVETSVGPVDTRMALTPSVTGDTRISVSPLGAIDMDSHDAPLRLDVEVERLDPDRSRALVAHPEEFSGLEDEVAADILRSTFDLGVRSGGAALVGATALGLAVYRTPRRALAAGGLALALLAASGAAAFATWNPKSVLEPKYSGLLTSAPSVIGDARSIVTEFDVYQQELARLVTNVSKLYDAASTLPAYRPDPSTVRFLHVSDMHLNPAAWGIIRSLVDQYELDAVIDTGDTMDHGSEAENVYLDPIATLGVPYVWVRGNHDSLATQAAVERQKNARVVDDGESVVVAGVRIAGIGDPQFTPDRSVAAAGDPAETAAGERLAAALAGLRDRGRPADLAIAHNPVALEQVDGLVPLALAGHRHNRKQHDLPDGTRLMVEGSAGGGGLRAVEQDVPEKVSASVLYLDRSTRRLQAWDEITLGGLGLTSAEVSRHLVEENQPGGADGTDPSGPPGEDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-10-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5Q0</accession>
    <name>A0A0F7N5Q0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_18820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH83910">
        <property type="protein sequence ID" value="AKH83910"/>
        <property type="gene ID" value="AA958_18820"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_18820"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3952"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="85" mass="9275" checksum="98F58B6A75EDF2D7" modified="2015-07-22" version="1">MQTKGRGSTFVLTRDRTRMTIATFQSLDKRGLVHLDTSVPLFQGRPITVTAEGHRALDQHRMHTETTAGPAAAPSPRAPAAAPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5R6</accession>
    <name>A0A0F7N5R6_9ACTN</name>
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        <submittedName>
            <fullName evidence="4">Cyclopropane-fatty-acyl-phospholipid synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_11680</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
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    <dbReference type="EnsemblBacteria" id="AKH82783">
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    </dbReference>
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    <dbReference type="PATRIC" id="fig|444103.5.peg.2456"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003333">
        <property type="entry name" value="Mycolic_cyclopropane_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020803">
        <property type="entry name" value="PKS_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003085">
        <property type="entry name" value="CMAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00828">
        <property type="entry name" value="PKS_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_MT" evidence="3">
        <location>
            <begin position="155"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH82783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="428" mass="47507" checksum="9F64DBC364A6FEE0" modified="2015-07-22" version="1">MPHGAAPRLAALAEELLGGPLPIRIRAWDRSEAGPEGAPVLVVRHRRALRRILWRPGELGLARAWVAGEIDVEGDLYAALDRLAGLLWDRGPDAPRPRPARLAAAARGALALARPLPPPPPPPEEVRRHKVRGALHTLRRDKAAVSHHYDVGNDFYSLVLGPSMVYSCAYWHEDGTLEDAQAAKLDLVCRKLGLREGDRLLDVGCGWGSMVLHAAREYGVRAVGITLSRQQAAYARKRVADAGLGDRVEIRVQDYRETADGPYDAISSIGMAEHVGSQRYGEYARVLHRLLRPGGRLLNHQIARRPLADEEDYAIDEFIDAYVFPDGELSPLSTTVDQLERAGFEVRDTQALREHYALTLRRWVANLEARWAQAVTLTSPGRARVWRLYMAASALSFERNRIGVNQVLAVRTPASGDSGLPLRQPRWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N661</accession>
    <name>A0A0F7N661_9ACTN</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_20015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
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            <taxon>Actinobacteria</taxon>
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        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_20015"/>
    <dbReference type="EnsemblBacteria" id="AKH84090">
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        <property type="gene ID" value="AA958_20015"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_20015"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4216"/>
    <dbReference type="OrthoDB" id="1908489at2"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007995">
        <property type="entry name" value="DUF742"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36221">
        <property type="entry name" value="PTHR36221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05331">
        <property type="entry name" value="DUF742"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="122" mass="13189" checksum="22E6856E193483E3" modified="2015-07-22" version="1">MTRPGRDDDPDRLYTLTGGRSRPASDEFDLVTLVVAEDEPAPGMQSEHAAILRICRTPTAVVELSADLGLPVGITKILLSDLLAAGRITARHPRYAPPRTPGGVRFADPETLEKVLVGLRHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N687</accession>
    <name>A0A0F7N687_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_12440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_12440"/>
    <dbReference type="EnsemblBacteria" id="AKH82908">
        <property type="protein sequence ID" value="AKH82908"/>
        <property type="gene ID" value="AA958_12440"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_12440"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2614"/>
    <dbReference type="OrthoDB" id="1859755at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH82908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="246" mass="25646" checksum="366C4E7C8A687F49" modified="2015-07-22" version="1">MSTTRHLINRRRRTAPPAEEARKPARRQPAAAVRARTRSRTGARPAEPAGKQPPAPARRPRPGARGRTGGDRTGAPTSARGGRLAAALGAAAVLLGCFAAFAAVQASGGGDPAADNAALVDAPLTSEVKGGVGEAVEAVFSVDYTDLDENRRAARTYLTGKAVAQHRDMLADVREQAPSQKLVLSTTVTDSAVELAGGGAARVLVFADQRNTRTDTDETSYGAAMVAVDAVKDDGRWRISHIDTFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6B5</accession>
    <name>A0A0F7N6B5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glyco_hydro_114 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_20430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017449.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_20430"/>
    <dbReference type="EnsemblBacteria" id="AKH84160">
        <property type="protein sequence ID" value="AKH84160"/>
        <property type="gene ID" value="AA958_20430"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_20430"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4305"/>
    <dbReference type="OrthoDB" id="1327691at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004352">
        <property type="entry name" value="GH114_TIM-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03537">
        <property type="entry name" value="Glyco_hydro_114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519184" description="Glyco_hydro_114 domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_114" evidence="2">
        <location>
            <begin position="49"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH84160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="318" mass="34916" checksum="451E99E46926C6CF" modified="2015-07-22" version="1">MTAIPALATTARRVLTFAVVAALATACMSRPESRDEGRWTPRPGEAADWDWQIDAPYELDEHRAMYDLDLFELAPAGSELRYPGGDVVKVPRGALAGTVEKLRARGTTVICYLDTGAYEHYRPDAARFPGHRPALAGIPDDGEAPEDGSVIGWNTGWEGERWLDLREGRRGAFAEIIWARLDLAARMGCDGVEPDQNNPLGNRPGFPITRDDQVSWYREVAEQAHARGLSVGMKNGHDQPGAVAELVGHFDWALPEECAQYGECARLRPFVEAGKAVFAVDYAPGADRRTACRAHRAENFDGLIKTAPPTGEYRKRCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6C2</accession>
    <name>A0A0F7N6C2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Extradiol ring-cleavage dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_12415</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DODA-type extradiol aromatic ring-opening dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016239.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_12415"/>
    <dbReference type="EnsemblBacteria" id="AKH82904">
        <property type="protein sequence ID" value="AKH82904"/>
        <property type="gene ID" value="AA958_12415"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_12415"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2609"/>
    <dbReference type="OrthoDB" id="1728007at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016701">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006725">
        <property type="term" value="P:cellular aromatic compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07363">
        <property type="entry name" value="45_DOPA_Dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014436">
        <property type="entry name" value="Extradiol_dOase_DODA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004183">
        <property type="entry name" value="Xdiol_dOase_suB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02900">
        <property type="entry name" value="LigB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006157">
        <property type="entry name" value="Doxgns_DODA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LigB" evidence="5">
        <location>
            <begin position="7"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH82904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="256" mass="27774" checksum="9D7CE626E06CE6E8" modified="2015-07-22" version="1">MPTMPALYLSHGAPPLADDPVWPAELAAWAAGLPRPRAVLVVSAHWEEAPAALGATTTVPLVYDFWGFPEHYYRVRYPAPGAPELAESVRTLLRSPGESVQDFPDRGLDHGAYVPLVEMYPDADIPVLQLSMPTLDPERLLALGRRLAPLRAEGVLIVGSGFFTHNLAALRHTGDGPPAWSAEFDAWGREALAAQDVDGLLDFVRKSPAGRLAHPRTEHFAPLFVALGAAEDDLPSQRSVIDGFWRGLAKRSLQLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6K2</accession>
    <name>A0A0F7N6K2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GCN5 family acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_12895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016308.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_12895"/>
    <dbReference type="EnsemblBacteria" id="AKH82974">
        <property type="protein sequence ID" value="AKH82974"/>
        <property type="gene ID" value="AA958_12895"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_12895"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2714"/>
    <dbReference type="OrthoDB" id="1581296at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="164"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="300" mass="33555" checksum="6C712D36FE6E8425" modified="2015-07-22" version="1">MTDPVIIRALTESDAPLFDALPDPLGAREGHRNTRFRTEWKHVALRDGRVVARGAWWGGPDDAEPLSVNWFDVAEGEEEAGTRLLLSVPWRVELEINLPGGWREEPALRAAADARFAAARAAGYELLVERFLYRWTPDRGLPERPGRLRFRAEPDDSVFFDALRRIHSATLDAHALKAIGEGGLDQAAQEEIDFFHWCPSPREWWQTAYTPEGELAGIHIPAHNPSGPIVGFIGVLPEQRGHGYSYDLLTECTHFLVERGAEFVSGATDRGNFPMAANFAKAGYPVVRERVNFHPADLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6M7</accession>
    <name>A0A0F7N6M7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_09680</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015795.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_09680"/>
    <dbReference type="EnsemblBacteria" id="AKH82452">
        <property type="protein sequence ID" value="AKH82452"/>
        <property type="gene ID" value="AA958_09680"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_09680"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2037"/>
    <dbReference type="OrthoDB" id="1221455at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="173"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="241"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="273"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl_transf_3" evidence="3">
        <location>
            <begin position="24"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="349"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH82452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="379" mass="42464" checksum="A8925B4D34F86C45" modified="2015-07-22" version="1">MTHLPQTAARPAGDSGKPKTRDPFFDNAKYLAIVLVALGHAWEPLRDDSRAASALYMLVYSFHMPAFIVISGYMSRSFDLGRPGRVQRLVTGVLVPYVIFETAYTFFNRWAGDVPGYRISILDPWYLTWFLIALFVWRMTTPLWKAVRWPVPLALVIATAASMSDTVGNDLDLQRVLQFMPFFVLGLMLKPEHFDLVRRREVRLLSVPVGLMAAVVAYWAVPRMNAGWFYHRDSAQELGAPIWAGPVMTFAMFGCALVLTVCFLAWVPRRTRWFTVLGAGTLYGYLLHGFLAKGSRFWGWYDNDFAHTPLGAIAVTAIAAAIVTVLCTPPVRRMFRWAMEPGMDWLFRSDDGGGRGGSPAAKPAAAEQTPERERASASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6T7</accession>
    <name>A0A0F7N6T7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">XRE family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_13475</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016404.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_13475"/>
    <dbReference type="EnsemblBacteria" id="AKH83074">
        <property type="protein sequence ID" value="AKH83074"/>
        <property type="gene ID" value="AA958_13475"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_13475"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2834"/>
    <dbReference type="OrthoDB" id="817710at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="3"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="127"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="127"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH83074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="226" mass="25157" checksum="1BB86E619502AD0B" modified="2015-07-22" version="1">MTRVLVVEDEESFSDALSYMLRKEGFEVAVATTGPEALDDFDRNGADLVLLDLMLPGLPGTEVCRQLRGRSNVPVIMVTAKDSEIDKVVGLEIGADDYVTKPFSSRELVARIRAVLRRRGEPEEAEPAALEVGPVRMDVDRHVVTVAGDKVDLPLKEFDLLEMLLRNAGRVLTRMQLIDRVWGADYVGDTKTLDVHVKRLRAKIEPDPGAPRYLVTVRGLGYKFEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6V1</accession>
    <name>A0A0F7N6V1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_18145</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH83811">
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        <property type="gene ID" value="AA958_18145"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_18145"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3815"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH83811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="97" mass="10877" checksum="35765CC7DCC04FDA" modified="2015-07-22" version="1">MADLKIKGDVLEDLFHTFTTMAKRLDYAARSMKGTDTDVVGAWMLIRELRDFAESWEYGIGQLGEHADGAAKMLTKIARDFDGLEKELEAALQPKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6W9</accession>
    <name>A0A0F7N6W9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_13760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_13760"/>
    <dbReference type="EnsemblBacteria" id="AKH83123">
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        <property type="gene ID" value="AA958_13760"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_13760"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2898"/>
    <dbReference type="OrthoDB" id="1920823at2"/>
    <dbReference type="Proteomes" id="UP000034283">
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    </dbReference>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="211" mass="22367" checksum="765424E165AB1B9F" modified="2015-07-22" version="1">MTMTDDVRKTLSDPTPLYAVAGTADLALEKLREVPALVERLRAEAPERLSAVRETDPREVQERVSKQAKEAQAKVAERLGDLDTDIKKLRETAQDLALQGVGRAAEYAVKARETYDELAERGRGAVAEWRGETADAVQVTTEIIRPGGEKTAAGEGVADKGADEDVAADDAPAAGKPAAKKAAPRKRAPRAGANGTAKKSAAKKNTPKADS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N787</accession>
    <name>A0A0F7N787_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_22190</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017716.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH84455">
        <property type="protein sequence ID" value="AKH84455"/>
        <property type="gene ID" value="AA958_22190"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_22190"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4673"/>
    <dbReference type="OrthoDB" id="1384345at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="27"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="259"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="316"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="350"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="378"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="29"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH84455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="409" mass="41509" checksum="91406D9C74690E49" modified="2015-07-22" version="1">MAAPTTSPAHPSGEPGRPRPGSAANGWPAVVSVTLGIFAIVTTEILPIGLLTEIGTSFTVSDGSAGLMMTMPGLLAAASAPVVTAASAHVDRRLMLCAFMALLAGANFLAAAAPDYWVVLASRVVVGVVIGGFWSIGASLAERLVPAPSVGRAKAVIFSAVPLGSVLGVPAGTLLGDLADWRTAFVALGALTVGVLVMLLVSVPLLPPTRTTRLHVLRGMLRGVNTRFALVVTVLIVLAHFGAYTYVTPFLEQVTEAGPRLITGLLLVYGAAGIIGNFLGGALVTRRPRGTFGLVAVVIAAATLLLPVLGGRPFGAVALLVLWGVAYGAVPVSSQTWFAKAAPHAPEAAAVLFTASFQATIALGALAGGVAVDQTSPSAVMTFGGGAAVLAAVAVWIHRTRRLTWPDGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7E7</accession>
    <name>A0A0F7N7E7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_11610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016108.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_11610"/>
    <dbReference type="EnsemblBacteria" id="AKH82772">
        <property type="protein sequence ID" value="AKH82772"/>
        <property type="gene ID" value="AA958_11610"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_11610"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2442"/>
    <dbReference type="OrthoDB" id="1973287at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025629">
        <property type="entry name" value="DUF4287"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14117">
        <property type="entry name" value="DUF4287"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH82772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="76" mass="8857" checksum="75E1C27CAD644E74" modified="2015-07-22" version="1">MSQVFSAETHRNLLSRIPHCTGREVSDWLQTVEDGPCLLRFEEKVSWLRGEHNLAYGHAKAIIHEYDLRRAARKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7I6</accession>
    <name>A0A0F7N7I6_9ACTN</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_22860</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_22860"/>
    <dbReference type="EnsemblBacteria" id="AKH84570">
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    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_22860"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4814"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519280" evidence="2">
        <location>
            <begin position="28"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH84570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="192" mass="19912" checksum="F036E4C0651DA46D" modified="2015-07-22" version="1">MRARTMVSVALAGCVALVACACGPGKAKDDSDAKAPRASEVSEPSASTGVEKPAGDPSPSAPSEKPSALPAGDGPAPKTKEGAIERYEVYLHAVGREDVDTVCEVAGPAAEKGEAEGVGPCTTAFLAMFQMISPEQKEALRTATVDPQGVTVLASDRVEIPAEAIRASVTFSDSELGRRTMGYLKDEWFITD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7W2</accession>
    <name>A0A0F7N7W2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_16140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016792.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_16140"/>
    <dbReference type="EnsemblBacteria" id="AKH83484">
        <property type="protein sequence ID" value="AKH83484"/>
        <property type="gene ID" value="AA958_16140"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_16140"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3401"/>
    <dbReference type="OrthoDB" id="912616at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="338"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="424"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="594" mass="61668" checksum="9D0E03B37FBE631D" modified="2015-07-22" version="1">MAERSTAAVDGSADDRSDAADTTEAADTEDPTGATEAPAAGARAAAAPDSGAAAAAAEPPAPDSSAGKPPAPEGPPRAGVPVADMHSGHKLADRYRLEECVTRLDGFSSWRAVDEKLRRAVGIHVLAAGHDHAEAVLDAARAAALIGDPRFVQILDAVEEDDVVYVVHEWLPDATELSTLLAGGAPMEPHEAYELVTQVSQALAAAHRKDLAHLRLTPSAVLRTGSGQWRIRGLSIHAALHGTEADDPQRTDTEAVGALLYAALTGRWPYEGDAYGLVGLPKHVGLIAPEKVRAGVHRGLSELAMRALAAGSPAAAEHPRPCTTPAELSAACAELPRIRPPEPQFPRSAPYQQTTYQQGYAQSGGRPGPAARPVAAVPPPAPPTLPGRTGKAVKWCVSVLLIVALALGSWQLADALINHDGRGGDTGNSAAQPGGGGGGSGGGREGGKPVEIESARDFDPYGTGSESPSSVPAAYDSDPSSYWETKWYTSAVFGNLKEGVGLVLDLGEPQRVGSVKVSLIGDSKLTAMATPQETGSMPTDLSGFEEFDAADGTNLTLKPTKPVVTQYVLLWLTEIPPSNEGNFRGKISDIQVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7Z2</accession>
    <name>A0A0F7N7Z2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_16555</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016858.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_16555"/>
    <dbReference type="EnsemblBacteria" id="AKH83553">
        <property type="protein sequence ID" value="AKH83553"/>
        <property type="gene ID" value="AA958_16555"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_16555"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3484"/>
    <dbReference type="OrthoDB" id="1650683at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001110">
        <property type="entry name" value="UPF0012_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01227">
        <property type="entry name" value="UPF0012"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CN hydrolase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH83553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="260" mass="27920" checksum="73D3C5B42A62648C" modified="2015-07-22" version="1">MRASLIQFRVDPDETVESRRARAAALVRAEEGSGLVVLPELWHVGAFAFDDFDAAAETLDGPTAAAMAAAARDAGVWLHAGSIVERDAAGTLFNTSLLYAPDGEPARTYRKIHRFGFDRGEAVLMGAGDEVVTVDLPGTVLGLATCYDLRFPELFRALTDKGAQTFVVPAGWPARRRAHWRLLAQARAVENQAFVLACGTAGTTGGVAQAGHSMIVDPWGEILAEAGEGEEVLRAELDPARVARTREEFPALRDRVLGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N880</accession>
    <name>A0A0F7N880_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_24020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018022.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_24020"/>
    <dbReference type="EnsemblBacteria" id="AKH84770">
        <property type="protein sequence ID" value="AKH84770"/>
        <property type="gene ID" value="AA958_24020"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_24020"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5062"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="26"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH84770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="254" mass="27609" checksum="FA330D1C624773E0" modified="2015-07-22" version="1">MSTASDRGARPAAPPPAVAYRRLSVSQRRSQLLAAALGLFAHRAPEDVSLDDVAAAAEVSRPLVYRYFPGGKQQLYEAALRSAADELELCFRQPQQGPLTRRLTRALDSYLGFVDEHDAGFKALLQGGSVVQTSRTTAIVDEVRRSAAEQILLHIGVPEPGHRLLTMIRTWITAVEGASLIWLDEGKQPPLPELRGWLVDHFIALLVATAAGDEECGRVLRRALELETAEGPAGDLVRRIAPFLPDAGHLLGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8D5</accession>
    <name>A0A0F7N8D5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein translocase subunit SecY</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">secY</name>
        <name evidence="11" type="ORF">AA958_21275</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 10">Belongs to the SecY/SEC61-alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017575.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_21275"/>
    <dbReference type="EnsemblBacteria" id="AKH84306">
        <property type="protein sequence ID" value="AKH84306"/>
        <property type="gene ID" value="AA958_21275"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_21275"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4480"/>
    <dbReference type="OrthoDB" id="1567535at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043952">
        <property type="term" value="P:protein transport by the Sec complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01465">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026593">
        <property type="entry name" value="SecY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002208">
        <property type="entry name" value="SecY/SEC61-alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030659">
        <property type="entry name" value="SecY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023201">
        <property type="entry name" value="SecY_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10906">
        <property type="entry name" value="PTHR10906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00344">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004557">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103491">
        <property type="entry name" value="SSF103491"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00967">
        <property type="entry name" value="3a0501s007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00755">
        <property type="entry name" value="SECY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="68"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="317"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="378"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AKH84306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="437" mass="47724" checksum="F70B263681C32F37" modified="2015-07-22" version="1">MLTAFARAFKTPDLRKKLLFVLGIIVIYRLGAQVPVPGTDYQAVQQCMDEANANQGLFGLVNMFSGGALLQITIFALGIMPYITASIILQLLTVVIPRLEALKKEGQSGTAKITQYTRYLTVALAVLQGTGLVATARSGSLFPQCQVNDQIIPDDSIFIIITMVICMTAGTAMVMWLGELITDRGIGNGMSMLMFISIAAGFPGALWNIKQSGKIIDGWGEFIVVIALGLAMVGLVVFVEQAQRRIPVQYAKRMIGRRSYGGTSTYIPLKVNQAGVIPVIFASSLLYIPALVVQFTGSNSGAAQWVEKNFVTGDHPVYIITYFLMIVFFAFFYVAITFNPEEVADNMKKYGGFIPGIRAGRPTAEYLSYVLNRITWPGSLYLGLIALVPTVALVLFKANQNFPFGGTSILIIVGVGLETVKQIESKLQQHHYEGFLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8L0</accession>
    <name>A0A0F7N8L0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_21625</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH84366">
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        <property type="gene ID" value="AA958_21625"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_21625"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4554"/>
    <dbReference type="Proteomes" id="UP000034283">
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH84366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="154" mass="15687" checksum="C832E7CF9DFA311C" modified="2015-07-22" version="1">MRRHRFEPAKLVAGLVLLSGAAFALLDAADALRQPDWVPLVVVPPGLALAGLVAAVGYGARRARRRAREARAAAARDRDVDVGADLRGLPMDELRGTYDARFGTRDADGPGAHDFGADGSGADDSGADGSGADGSGADGDVDAGGRRRGPGSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8P3</accession>
    <name>A0A0F7N8P3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
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            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017673.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_21935"/>
    <dbReference type="EnsemblBacteria" id="AKH84411">
        <property type="protein sequence ID" value="AKH84411"/>
        <property type="gene ID" value="AA958_21935"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_21935"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4619"/>
    <dbReference type="OrthoDB" id="1231997at2"/>
    <dbReference type="Proteomes" id="UP000034283">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="373" mass="39702" checksum="D0C11559B4F3496C" modified="2015-07-22" version="1">MTGDGAGGTTVALVESPVQLLNVLEWAYQGGTVIPLTVVVLPPTEPLSRGQLRRMAELAMDDGLDVRWQEARGGAGPLRTMTSLARPLRRARRVVLGDPFSRYVQTLLTVVKAREVVVVDDGTATMEFTAQLSRGERFVRWHRSGRSGGARGMLFAPVASAARRRLTPAGSGAPGASGTRVEVFTSMPVVDPPSGLKVTANEFAWTRSRFGPPSVGTATDLVGTSLVETGVVDHDRYLEAVASLTKAYGATRYFAHRRERADKLHRLHLHTGLEIVRPDLPLEIVARRGPIGRTIVSFPSTVVHTLPLALAGTGVKVAVCEVDPSWLTETASPRAQGFLSSVAGAARERRGVDRLPVGPATATGWSGAPAASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8Z7</accession>
    <name>A0A0F7N8Z7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_14345</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016533.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_14345"/>
    <dbReference type="EnsemblBacteria" id="AKH83217">
        <property type="protein sequence ID" value="AKH83217"/>
        <property type="gene ID" value="AA958_14345"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_14345"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3019"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025338">
        <property type="entry name" value="DUF4244"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14029">
        <property type="entry name" value="DUF4244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH83217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="66" mass="6887" checksum="EC5C88C435CEBEA5" modified="2015-07-22" version="1">MAGRFIRRVRACVRRLGGDAGMTTSEYAVGTIAAVAFAAILYKVVTSDAVGGALQAVVERALDVPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N968</accession>
    <name>A0A0F7N968_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_19865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017353.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_19865"/>
    <dbReference type="EnsemblBacteria" id="AKH84063">
        <property type="protein sequence ID" value="AKH84063"/>
        <property type="gene ID" value="AA958_19865"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_19865"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4186"/>
    <dbReference type="OrthoDB" id="687243at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021345">
        <property type="entry name" value="DUF2961"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11175">
        <property type="entry name" value="DUF2961"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="367" mass="39950" checksum="AE232ABE2E6CF298" modified="2015-07-22" version="1">MSTTFGLDDLARTTPAVTRSISAENPTGAKGAGGAATEGTGARAAGRLGQGWKVSPSIDIAAGETAVLAEIDGPGTIRHLWCTTAPHAAWRQTLLRIYWDGAETPAVEVPLGDFFCNGWSVFSQVSSVPVTVAPNGGFNAYWPMPFRRRARVTLENLAPEQMTLYYQIDYELADVPADASYLHAQWRRSNPVDESGIHTLLDGVTGAGQYVGTYLAWGTNSPGWWGEGELKFYLDGDEDWPTICGTGTEDYFGGAWNFDVKPHGYTAYTTPYLGLNQILRPDGLYASQQRFGMYRWHVLDPVRFQEDLRVTVQCLGIGAGQGNGLKHRYRKNRDDIASTSLFYLDAPSSAALPATPGLLDLEVDAPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9E0</accession>
    <name>A0A0F7N9E0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4031 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_19815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017344.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_19815"/>
    <dbReference type="EnsemblBacteria" id="AKH84054">
        <property type="protein sequence ID" value="AKH84054"/>
        <property type="gene ID" value="AA958_19815"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_19815"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4175"/>
    <dbReference type="OrthoDB" id="1086845at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025109">
        <property type="entry name" value="DUF4031"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13223">
        <property type="entry name" value="DUF4031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4031" evidence="1">
        <location>
            <begin position="3"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="90" mass="10030" checksum="8821A5D74E9B6607" modified="2015-07-22" version="1">MTIYVDPPTWPGHGRMWSHLVSDVSYEELHAFAESMGVPRKAFDGDHYDIPSTRYGDAVSRGAVEVGSKELLRRLVEGGLRRRGRKTGTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9N9</accession>
    <name>A0A0F7N9N9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acyl-CoA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_26885</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018497.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_26885"/>
    <dbReference type="EnsemblBacteria" id="AKH85260">
        <property type="protein sequence ID" value="AKH85260"/>
        <property type="gene ID" value="AA958_26885"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_26885"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5655"/>
    <dbReference type="OrthoDB" id="445933at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032875">
        <property type="entry name" value="Succ_CoA_lig_flav_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13380">
        <property type="entry name" value="CoA_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13607">
        <property type="entry name" value="Succ_CoA_lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="SSF52210"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="25"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="3">
        <location>
            <begin position="781"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="708"/>
            <end position="772"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH85260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="999" mass="103586" checksum="564010FDA7DC71B9" modified="2015-07-22" version="1">MATPSAPEYPTHWEADVVLRDGGTAQIRPIVPDDADRLVAFFDRVSDESKYLRFFAPHPRLSARDVHRFTHHDYVDRVGLAAVVGDAFIATVRYDRIEPAADGAPQAEVAFLVQDDQQGRGVASALLEHIAACARERGVRRFVADVLPANSRMMKVFTDAGYTQKRSFEDGVVRLEFELEPTERSLAVMHAREQRAEARSVQRLLAPRSVAVIGVGRRPGGVGRTVLANLLAGGFTGRLYAVNHAYPEGRDRLLPEDVPARRSVRDIDEPVDLAVVAVPAARVPDVVDDCGEQGVQGLVVLSSGYAEAGAAGRARQRDLVRQARGHGMRVIGPNAFGVLNTAPPVRLNATLAPDPADSGRVGVFTQSGAIGIALLSGLHRRPGAVLTGVSTFVSAGNRADVSGNDLLQYWHDDAATDVVLMYLESLGNPRKFTRLARRTAAVKPVVVVKGARHSASTPPGHAVPGTSVPAETVGALLRQAGVVAVDTVTELVDTGLLLAAQPLPAGPRVAIVGNSDSLGLLAYDACRAAGLRPLPPRDLTAAAAPEDFRAAVAAALAEDGCDAVLVTAIPWGIPGPLGPRGRAADPDVPALAAVPGPSPRSRGDWGDRGDAGALADALRAAAAGATKPVAVVHLEIEGLPGALAAPPDGIPTYPAGERAARALAQAVRYAQWRRRAADPGRVPEYDDLDPAGAAADIAALLGERGRAAGDEGGVAPDWAPGGAWRAAEGDGAAGAGPAGAGAGTAADGAGAAAARTARRTPAPPAPYPEGVPVDVPEQAAARVLRRYGIDVLPALPAPDPDAAAAAAARLGYPVALKTTAVHLRHRPDLGGVRLDLAGEDQLRLAHAELTATLGAAAEVQPVVQAMAPRGVDTVVRAAVDPGVGAVLSFGLAGAPSELLGDLAHRLVPATDRDAAELIRAIRGAPLLFGWRGAQPVDTAALEELLLRLSIFVDEHPEVVSAELSPVVVAPQGVSVLSAALRLAPPPPRIDLGARRMPRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9X4</accession>
    <name>A0A0F7N9X4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_21335</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017582.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_21335"/>
    <dbReference type="EnsemblBacteria" id="AKH84318">
        <property type="protein sequence ID" value="AKH84318"/>
        <property type="gene ID" value="AA958_21335"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_21335"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4492"/>
    <dbReference type="OrthoDB" id="1928091at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519885" evidence="1">
        <location>
            <begin position="23"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="Epimerase" evidence="2">
        <location>
            <begin position="3"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH84318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="320" mass="33841" checksum="0FB84081C37B574B" modified="2015-07-22" version="1">MKILVTGATGALGSRLVPLLNAAGHTVTGTTTSEAKTERLRAAGAEPVVLDVLDAAAVRAAVANAAPEVIVHEATALSQQTSLSARDLRRLDTVFATTNRLRSEGTDNLLAAAAETGTRRFIAQSFAGWPYKREGGLIKTEDDPLDTTPPPGTEQSLGAMKHLEEAVTSAPGIEGIVLRYGGFYGPGTTIYPGGEQAEMVRKRLLPLVGRGEGVISLIHIDDAAAATAAAVERGTPGIYNITDDDPAAQKEWLPRLAAAMGARPPRRLPVWLARLAAGKWVTTVMTEGRGAANDKAKRELGWQPGHPTWREGFTEVFAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NA79</accession>
    <name>A0A0F7NA79_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Inosine-5-monophosphate dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.205</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_21515</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IMPDH/GMPR family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.205" evidence="3"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017611.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_21515"/>
    <dbReference type="EnsemblBacteria" id="AKH84349">
        <property type="protein sequence ID" value="AKH84349"/>
        <property type="gene ID" value="AA958_21515"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_21515"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4529"/>
    <dbReference type="OrthoDB" id="532857at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003938">
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH84349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="371" mass="39676" checksum="C50496B720AC10D8" modified="2015-07-22" version="1">MTEIEIGRGKRGRTAYAFDDIAIVPSRRTRDPKEVSIAWQIDAYRFELPFLAAPMDSVVSPEAAIRIGRFGGLGVLNLEGLWTRYENPEPLLAEIAGLDERDATRRMQEIYDEPIKEELIGRRLAEVRESGVVTAAALSPQRTAQFSKAVVDAGVDIFVIRGTTVSAEHVSSAAEPLNLKQFIYELDVPVIVGGCATYTAALHLMRTGAAGVLVGFGGGAAHTTRNVLGIQVPMATAVADVAAARRDYMDESGGRYVHVIADGGVGWSGDLPKAVACGADAVMMGSPLARATDAPGRGHHWGMEAVHEDVPRGKVMDLGTVGTTEEVLLGPSHTPDGSMNFFGALRRAMATTGYSELKEFQRVEVTVAASR</sequence>
</entry>
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
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    </evidence>
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</entry>
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                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AKH84414.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="68" mass="7132" checksum="9520FEC22501ED9B" modified="2015-07-22" version="1">MAIMSMAIISRGLSTGRRWRLSPEAPLTGGRGDWMSQGPAGAAAMYRGGPGRRGLSGPDEGVREDFAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAQ6</accession>
    <name>A0A0F7NAQ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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    </dbReference>
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        <property type="gene ID" value="AA958_29010"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_29010"/>
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH85615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="111" mass="12636" checksum="5DE51CA07B2D92AE" modified="2015-07-22" version="1">MSEREYFAQFAKRTGMFIGRTSLTGVTAFMVGYDQAAQRRGGPGLDGWREWLMKYVQVSGNLVWEAQIRQVALPGWEGGWELTPEQEAHVLKVLFELFDKFLADRDTASDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAU6</accession>
    <name>A0A0F7NAU6_9ACTN</name>
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        </submittedName>
    </protein>
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    </gene>
    <organism evidence="3 4">
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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    </dbReference>
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        <location>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="2">
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            <end position="106"/>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH85206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="152" mass="16201" checksum="887FAE117F71E1B7" modified="2015-07-22" version="1">MEASPRDSRREPRDDRIAGPVAEPADDLAGDLTDAPEPVGQESFRELRPPRLLRFWQLAPIVALAALGSLMFAFPLAFEFGGGGPVVAMLGLLISCCAAGWAMMAARRVGLALPGLPRRGSGRRADWRIALLYAVAVAAVVALAVWRVARLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBA8</accession>
    <name>A0A0F7NBA8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_23915</name>
    </gene>
    <organism evidence="1 2">
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        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018001.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH84749">
        <property type="protein sequence ID" value="AKH84749"/>
        <property type="gene ID" value="AA958_23915"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_23915"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5040"/>
    <dbReference type="OrthoDB" id="2089513at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH84749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="73" mass="7391" checksum="4F6A553F18BA691B" modified="2015-07-22" version="1">MENPLSAKPDGIPSAAGSAVRLPDFSDVDVYAVAARGEPPVLAGAVAHLLRNWPSDNDAAAYFENGGKPGDGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBB2</accession>
    <name>A0A0F7NBB2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AA958_23940</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018006.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_23940"/>
    <dbReference type="EnsemblBacteria" id="AKH84754">
        <property type="protein sequence ID" value="AKH84754"/>
        <property type="gene ID" value="AA958_23940"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_23940"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5046"/>
    <dbReference type="OrthoDB" id="1827824at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="10">
        <location>
            <begin position="78"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="138"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AKH84754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="376" mass="40319" checksum="6CD99B6CACEE6348" modified="2015-07-22" version="1">MTVPDGGGEPGFWRRVWDALRPLDPVRSVNAALGALVIGSVVIATGLVWVAIRSSTEVRLITVFSLIASLLITQFVGQRLTSPLVQMTAVTRAMAHGDYTARLATRRRDEFGELAQTFNRMAADLQSVDRHRKELVANVSHELRTPIAALRAVLENVVDGVSEADPDTMRTALRQTERLGRLVEQLLDLSRIDSGVVPLRLRRFAVEPYLAGVLKEAHFGTGAHGTAGAPEGDGDVPGPRGRGDVRLHLDVSPPELSVRADPERLHQVMANLIDNAVKHSPPGGRVTVRARAGAQPDALEVEVLDEGPGIPAAERHRVFERFNRGRENGVLGGHGADGGGTGLGLAIARWAVDLHGGRIGVAESPRGCRIKLTLPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBS2</accession>
    <name>A0A0F7NBS2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ATP synthase subunit c</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">ATP synthase F(0) sector subunit c</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">F-type ATPase subunit c</fullName>
            <shortName evidence="13">F-ATPase subunit c</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Lipid-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">atpE</name>
        <name evidence="15" type="ORF">AA958_24850</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.</text>
    </comment>
    <comment type="function">
        <text evidence="13">Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cell membrane</location>
            <topology evidence="13">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the ATPase C chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_026276655.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_24850"/>
    <dbReference type="EnsemblBacteria" id="AKH84898">
        <property type="protein sequence ID" value="AKH84898"/>
        <property type="gene ID" value="AA958_24850"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_24850"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5239"/>
    <dbReference type="OrthoDB" id="2078221at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045263">
        <property type="term" value="C:proton-transporting ATP synthase complex, coupling factor F(o)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01396">
        <property type="entry name" value="ATP_synth_c_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005953">
        <property type="entry name" value="ATP_synth_csu_bac/chlpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000454">
        <property type="entry name" value="ATP_synth_F0_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020537">
        <property type="entry name" value="ATP_synth_F0_csu_DDCD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038662">
        <property type="entry name" value="ATP_synth_F0_csu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10031">
        <property type="entry name" value="PTHR10031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00124">
        <property type="entry name" value="ATPASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="SSF81333"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01260">
        <property type="entry name" value="ATP_synt_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00605">
        <property type="entry name" value="ATPASE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 13" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="13" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 13" id="KW-0138">CF(0)</keyword>
    <keyword evidence="6 13" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 13" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_C" evidence="14">
        <location>
            <begin position="19"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="site" description="Reversibly protonated during proton transport" evidence="13">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AKH84898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="80" mass="8215" checksum="F12DCE5E43C9C631" modified="2015-07-22" version="1">MAVMETLAAVEIKGNLGAIGYGLAAIGPGVGIGYIFGNGVQAMARQPEAVGLIRQNMILGFAFCEALALIGIVMPFVYPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBV2</accession>
    <name>A0A0F7NBV2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH gntR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_29345</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018895.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_29345"/>
    <dbReference type="EnsemblBacteria" id="AKH85666">
        <property type="protein sequence ID" value="AKH85666"/>
        <property type="gene ID" value="AA958_29345"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_29345"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6190"/>
    <dbReference type="OrthoDB" id="1875458at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="13"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH85666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="254" mass="28075" checksum="644C2B710A1EE1BD" modified="2015-07-22" version="1">MLEATGWQPLIRSRAWEQVVDRVEEKILSGDLRIGDRLPPERDLASMLGVSRAAVREALRVLEAHGVLHRPRVGTGRDSGSVIAGTPTTGLSRLLRVHVALSNFDLDEITEARVALERASASLAASQATESDLARMRELLDRMDDETLPRDRFNDLDTDFHMALAEAADNRLVTALTTAIRGAIRHTLLHAFEQLADADAVLNALRRQHRSLFEAVAQGDADRAADEVDRHIRGFHRIASHTLNRSVPRTPPAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NC27</accession>
    <name>A0A0F7NC27_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sodium:solute symporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_31790</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019268.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_31790"/>
    <dbReference type="EnsemblBacteria" id="AKH86040">
        <property type="protein sequence ID" value="AKH86040"/>
        <property type="gene ID" value="AA958_31790"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_31790"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6714"/>
    <dbReference type="OrthoDB" id="278483at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="117"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="304"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="340"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="391"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="455"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="481"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="515"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="546"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH86040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="597" mass="62585" checksum="A174BA4B5A881FC7" modified="2015-07-22" version="1">MNTLQPAIAVAVVCLATALFGVYGLRPGRATSDFYVASRAVTPLQNASAIGGEYLSAASFLGIAGLVLAYGADMLWYGVGYTAGYLVLLAFVAAPMRRSGAYTVPDFAEARLQSKRVRQLASVLVVLIGWLYLLPQLQGAGLTLRTVTGAPLWVGPVAVAAVVMTTVASGGMRSVTAVQAFQYWLKLTALAVPVIFLLLAWRADGAPWPDADAPPRFRDATTVTVHQAVDVRVEDPVRVTVHGRLDGERLDGERVRIGPGVHAIGEETRVRFPAGADVPHPVDEEPVDGLDWTRPLSGTEHPGYGTYSLLIATLLGTMGLPHVIVRFYTNPDGPAARRTTWTVLWLLAAFYLLPPLYGALGRLYTPELLMTGRTDATLLLLPDRLLGGGPAAAVLGTLLTAGAFAAFLSTASGLTMSVAGVLGQELERRRARRATAPPGKAADARAEVRATVRRLRLAGVAAAAVPCVASLVVVERPVADVVGLAFAVAASSFCPLLLLGIWWRGLTPQGAAAGLLTGGGAALATVAATMFGVQPGGWPGALLARPAAWTVPLAFAVMVGVSWLTRRSVPSGTAHALLRLHAPETLDLPRRPGRTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-10-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NC35</accession>
    <name>A0A0F7NC35_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_25330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018234.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH84983">
        <property type="protein sequence ID" value="AKH84983"/>
        <property type="gene ID" value="AA958_25330"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_25330"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5338"/>
    <dbReference type="OrthoDB" id="1439189at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH84983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="315" mass="34111" checksum="586151AC205F763A" modified="2015-07-22" version="1">MRHLRALCAISDAGSVHGAARWLGVSQPALTAQLNRIERAVGGPLFVRDRSGCRPTPLGRSVTARARPIIAEMSTLVSEAREEARALESGPRLRLGSTANRAVAGWLCRLHGRFPDTDVSIRVDPSPNSLLRMVADGHLDVAFVHEVTGCPLRVPDGVGQRTLLWREPQFVALPAAHPAAAGEDVALADLCGHPWVVDPHVDGEWHGIRRMFASAGLELRVIQGDYLTGADLVRAGVAVTPCQPTSTPRPGMAIRPLRGDPLTVRLLLAARAASTTDGEFHAVYTALEDAYREAARSTETYLRWLHRNDNPLLLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NC38</accession>
    <name>A0A0F7NC38_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">DNA ligase</fullName>
            <ecNumber evidence="9 10">6.5.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Polydeoxyribonucleotide synthase [NAD(+)]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ligA</name>
        <name evidence="13" type="ORF">AA958_25470</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the NAD-dependent DNA ligase family. LigA subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.2" evidence="9 10"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018260.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_25470"/>
    <dbReference type="EnsemblBacteria" id="AKH85009">
        <property type="protein sequence ID" value="AKH85009"/>
        <property type="gene ID" value="AA958_25470"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_25470"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5368"/>
    <dbReference type="OrthoDB" id="241401at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003911">
        <property type="term" value="F:DNA ligase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00114">
        <property type="entry name" value="LIGANc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01588">
        <property type="entry name" value="DNA_ligase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041663">
        <property type="entry name" value="DisA/LigA_HHH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018239">
        <property type="entry name" value="DNA_ligase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033136">
        <property type="entry name" value="DNA_ligase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001679">
        <property type="entry name" value="DNAligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013839">
        <property type="entry name" value="DNAligase_adenylation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013840">
        <property type="entry name" value="DNAligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004150">
        <property type="entry name" value="NAD_DNA_ligase_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004149">
        <property type="entry name" value="Znf_DNAligase_C4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01653">
        <property type="entry name" value="DNA_ligase_aden"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03120">
        <property type="entry name" value="DNA_ligase_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03119">
        <property type="entry name" value="DNA_ligase_ZBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12826">
        <property type="entry name" value="HHH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001604">
        <property type="entry name" value="LigA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00532">
        <property type="entry name" value="LIGANc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="SSF52113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00575">
        <property type="entry name" value="dnlj"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01055">
        <property type="entry name" value="DNA_LIGASE_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01056">
        <property type="entry name" value="DNA_LIGASE_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 9 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2 9 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="1 9 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9 10" id="KW-0520">NAD</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="BRCT" evidence="12">
        <location>
            <begin position="627"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="active site" description="N6-AMP-lysine intermediate" evidence="9">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="34"/>
            <end position="38"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="83"/>
            <end position="84"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="408"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="411"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="427"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="433"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AKH85009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="719" mass="79310" checksum="05D82DFEFD8D7474" modified="2015-07-22" version="1">MSTDSVARERHRLLAEQIEEHRFRYYVTTPVISDADFDKLLRELEALEEEHPELVTPDSPTQKVAGAYETEFTSVRHRERMLSLDNAFTDEELDAWADRMARELDPQPYHLLCELKVDGLAVNLTYEHGRLVRGATRGDGRAGEEITPNIRTIGEIPHRLRGENVPDLVEIRGEVYFSLADFQKLNEDLVAEGKPPFANPRNSAAGSLRQKNPQVSASRPLHMVVHGIGALEGARFDRLSGAYDLLKEWGLPTSPYTKVVDGIDGVRAFISRYGERRHDVAYEFDGVVVKLDEIALQGRLGSTSRAPRWAIAWKFPPEEVNTKLVDIRVGVGRTGRVTPYAVVEPVTVAGSEVEFATLHNQDVVKAKGVLIGDTVALRKAGDVIPEIMGPLTDLRDGSEREFVMPAECPECGTALKPMKEGDVDLRCPNARSCPAQLRERLFYLAGRRCLDIENFGYVAATALTQPLEPAEPPLRDEGGLFDLKVEDLLPIKSYVLDQDTGLPKRDPETGEEKVVTFFANKEGNPKKNTELMLGHIRAAKDRPLARVIAGLSIRHVGPVAAEALAREFRSIDRIMAASEEELAAAEGVGPTIAASLTQWFAEDWHREIVERWRAAGVRMEEEVKESEGARPLEGLTVVVTGTLQSHTRDGAKEALQSRGAKVTGSVSKKTDFVVCGDNPGSKYDKAVQLKLPILDDAGFAVLLEQGPDAARDAALPPPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NC40</accession>
    <name>A0A0F7NC40_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_25360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018239.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_25360"/>
    <dbReference type="EnsemblBacteria" id="AKH84988">
        <property type="protein sequence ID" value="AKH84988"/>
        <property type="gene ID" value="AA958_25360"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_25360"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5345"/>
    <dbReference type="OrthoDB" id="191097at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519482" evidence="1">
        <location>
            <begin position="32"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="428" mass="44197" checksum="1353D9FF9B92F1E4" modified="2015-07-22" version="1">MSATSLSRRGVLAGAVAGALASPLAAVPAHAARTRGLLIFVALDGFGIDYLDGRAPMPHLTSLVRAGSLTTSTGVMASITNQSWTAVSCGAHPDRTRNAAYYYDEAAGVARGQSRDSAVEGLAQAWRPQGIRIGSAQWFILQDKGTSYGDPDGLYTQPGGRIGARVDDAVAMLTGRPVDSGGTAVTLTRRPDFLAVYSSDLDGDGHAFGPDDPRMLDTLRETDAGIGRLIRTVKDLGLYGRTTWVVTGDHGMTGWKTPMAAQAVAALATAGFTPEVIGSGGRPAPETDAVLVSGGSIASVHLLGAGAADAAAIERARAALADAEGVAAVLTKADQAALRMAPQYGQLVLELAAPYALSFTPPAEGFDGRHGSRAETAVPLILAGHRIRRGRAPRDPRHVDLAATMSAILGVAPPAQSEGRVLRESLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NC51</accession>
    <name>A0A0F7NC51_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GCN5 family acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_30185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019009.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_30185"/>
    <dbReference type="EnsemblBacteria" id="AKH85781">
        <property type="protein sequence ID" value="AKH85781"/>
        <property type="gene ID" value="AA958_30185"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_30185"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6374"/>
    <dbReference type="OrthoDB" id="1538300at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="13"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="190" mass="20885" checksum="87E8F88330D0ED67" modified="2015-07-22" version="1">MTLATPTLHTARLRLRPFTGADADPLFTLHSSTHAMRYWDSPPWTERARAGVFLARCRTMAEEGTGARVAIDRASDGAFVGWCGLTAFDPDHRSASLGYILDPAMWGHGYATEAAHAVLRWAFDTLDLNRVQAEADTRNAASARVLEKAGFVREGTLREDCVVNGEVSDSWVYGLIRRDWHPSATQVPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NC59</accession>
    <name>A0A0F7NC59_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ferredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_31940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019293.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_31940"/>
    <dbReference type="EnsemblBacteria" id="AKH86065">
        <property type="protein sequence ID" value="AKH86065"/>
        <property type="gene ID" value="AA958_31940"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_31940"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6745"/>
    <dbReference type="OrthoDB" id="1873445at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="90" mass="9097" checksum="AF9BD5FE8CCE77C1" modified="2015-07-22" version="1">MEIRVDRARCVGAGLCMMHVPAVFDQSEDDGKVLLTTARPGPALARSVRAAAGRCPGRAISLHDGAGSEDSDGAAGTERADTTTGSGSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NC82</accession>
    <name>A0A0F7NC82_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 8">Adenylate kinase</fullName>
            <shortName evidence="6">AK</shortName>
            <ecNumber evidence="6 8">2.7.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP-AMP transphosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">ATP:AMP phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Adenylate monophosphate kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">adk</name>
        <name evidence="10" type="ORF">AA958_21280</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 8">
            <text>AMP + ATP = 2 ADP</text>
            <dbReference type="Rhea" id="RHEA:12973"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from ADP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 8">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="6">Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the adenylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="6 8"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017576.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_21280"/>
    <dbReference type="EnsemblBacteria" id="AKH84307">
        <property type="protein sequence ID" value="AKH84307"/>
        <property type="gene ID" value="AA958_21280"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_21280"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4481"/>
    <dbReference type="OrthoDB" id="1491686at2"/>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00649"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:adenylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006259">
        <property type="entry name" value="Adenyl_kin_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007862">
        <property type="entry name" value="Adenylate_kinase_lid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="PTHR23359"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05191">
        <property type="entry name" value="ADK_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01351">
        <property type="entry name" value="adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="4 6 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ADK_lid" evidence="9">
        <location>
            <begin position="127"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="NMP" evidence="6">
        <location>
            <begin position="30"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="10"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="57"/>
            <end position="59"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="85"/>
            <end position="88"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="137"/>
            <end position="138"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AKH84307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="222" mass="24106" checksum="6732646D2ADF1D2F" modified="2015-07-22" version="1">MRIVLVGPPGAGKGTQAALLAKNLSIPHVSTGDLFRANISKGTELGRQARAYMEAGNLVPDEVTVGMAWDRMEQPDAAGGFLLDGFPRNVAQAVALDGLMKEAGLELDAVLDLEVPEDEVVKRIAGRRICRNDSSHVFHVTYSPPEREGVCDVCGGELYQRDDDNEDTVRRRLEVYHEETEPIIDYFKAQGLVTTISALGSVAEVTRRAMEALPGEVSADRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NC93</accession>
    <name>A0A0F7NC93_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Chromosome partition protein Smc</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">smc</name>
        <name evidence="9" type="ORF">AA958_25870</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Required for chromosome condensation and partitioning.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="5">Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SMC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018322.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_25870"/>
    <dbReference type="EnsemblBacteria" id="AKH85079">
        <property type="protein sequence ID" value="AKH85079"/>
        <property type="gene ID" value="AA958_25870"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_25870"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5448"/>
    <dbReference type="OrthoDB" id="1149850at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030261">
        <property type="term" value="P:chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01894">
        <property type="entry name" value="Smc_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011890">
        <property type="entry name" value="SMC_prok"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="SSF75553"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02168">
        <property type="entry name" value="SMC_prok_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519399" description="Chromosome partition protein Smc" evidence="7">
        <location>
            <begin position="18"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="domain" description="SMC hinge" evidence="8">
        <location>
            <begin position="512"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="309"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="759"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="945"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="167"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="248"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="655"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="1007"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="313"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="759"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="801"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="962"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="32"/>
            <end position="39"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH85079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="1192" mass="128630" checksum="4569E66CE683BF78" modified="2015-07-22" version="1">MHLKGLTLRGFKSFASATTLRFGPGITCVVGPNGSGKSNVVDALSWVMGEQGAKSLRGGKMEDVIFAGTTGRPPLGRAEVSLTIDNSDGALPIDYSEVTITRTMFRSGGSEYQLNGDTCRLLDIQELLSDSGIGREMHVIVGQGQLDSVLHADPSGRRAFIEEAAGVLKHRKRKEKALRKLDAMQANLARVQDLGDELRRQLKPLGRQAAVARRAAVIQADLRDARLRLLADDLVTLRAALSAEIADEAALKERKEATEAELTAARARESALEEQVRALTPRLTEAQGAWHELGQLAERVRGTVSLADARAKHATAAPEDERRGRDPEDLEREAQRIRQQEAELEAALEAAERALEDTVAHRAELERELAAEERRLKDAARAVADRRERLARLSGKVTAARGRAASAQAEIDRLATARDEAEERAAAAQEAYETLKAEVDGLAGDDSELAAEQEAAKSALKAAEAELTAARDETAEAERARAATTARRDALALGLRRKDGTGTLLQARDKLSGVLGPAAELLTVAPGYEVAVAAALGAAADALAVSGPAAAADALRLLRKHDAGRAALLLGDAPYEPLPDGELPPGARHLAALVAGPDQLLPAVRRLLARTVYVATLEEAEDLVSLRPELTAVTAEGDLFGGHFAHGGSAGAPSLLEVQASVDEAAAELTELDARCLRLRDRQEAAVARRAECAALVEELGGRRSAADREKSRVAGELGRLAGQARAAAGEAERSAAAAARAEEALARAGAEAEELAAQLETAEEEAGAAEDGDDGSDSDTSVRDRLAADGANARQTEMEARLQVRTHEERVKGLAGRADGLDRAARAEREARTRAERRRARLRHEAAVATAVAAGARQLLAHVEVSLARAEEERAAAERARAEREQELGRQRRLSRELAGELDKLTDSVHRGEVLGAEKRLRIEQLEGRALEELGVEPADLVAEYGPDQPVPPSLPAEGEELPEDPEHPRNRPRPYVRTEQEKRLKAAERAYTKLGKVNPLALEEFAALEERHKFLTEQLDDLKRTRADLLQVVKEVDERVEQVFTDAFHDTAREFEGVFSRLFPGGEGRLILTDPDDMLNTGVEVEARPPGKKVKRLSLLSGGERSLTAVAMLVAIFMARPSPFYVMDEVEAALDDTNLQRLVRLMQELQRTSQLIVITHQKRTMEVADVLYGVSMQGDGVSKVISQRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NC94</accession>
    <name>A0A0F7NC94_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Saccharopine dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_32045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019313.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_32045"/>
    <dbReference type="EnsemblBacteria" id="AKH86085">
        <property type="protein sequence ID" value="AKH86085"/>
        <property type="gene ID" value="AA958_32045"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_32045"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6766"/>
    <dbReference type="OrthoDB" id="1006830at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005097">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03435">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sacchrp_dh_NADP" evidence="1">
        <location>
            <begin position="11"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="394" mass="41579" checksum="1808204D13D99380" modified="2015-07-22" version="1">MADEPRPHDLILFGATGFTGGLTAEYLARHAPAGCRWALAGRDTGRLAEVRDRVAAIRPEWGDLPLLTADAADPAALRGLAERTRVVATAVGPFLRHGEPLAAACAAAGTDYADLTGEPEFVDRVYVRHHERARETGARLVHACGFECTPFDLGVRFTVGQLPEDVPLRIDGFLRAAGGLSGGTLASALGVVSRPLPGARAARARRRMEPRVTGRRVRAPLGAPTRSGAVRAWGLPLPTLESRVVARSAAALPRYGPDFRYRHYAAVRRLPVAAGSVLGAGAFAAAAQLPPLRKLMASRLAPGTGPVEQRRARSWFSARFVGTGGGRRVVTEVSGGDPGYDESAKMLAEAAMCLAYDPLPETSGQVTTAQAMGEALTARLVTAGMGFRVWVASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCA6</accession>
    <name>A0A0F7NCA6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Branched-chain-amino-acid aminotransferase</fullName>
            <ecNumber evidence="15">2.6.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">AA958_25620</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>2-oxoglutarate + L-isoleucine = (S)-3-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 15">
            <text>2-oxoglutarate + L-leucine = 4-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:18321"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 15">
            <text>2-oxoglutarate + L-valine = 3-methyl-2-oxobutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24813"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4 14">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 16">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 4/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7 16">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 4/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6 16">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 13">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.42" evidence="15"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018288.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_25620"/>
    <dbReference type="EnsemblBacteria" id="AKH85038">
        <property type="protein sequence ID" value="AKH85038"/>
        <property type="gene ID" value="AA958_25620"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_25620"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5402"/>
    <dbReference type="OrthoDB" id="1275805at2"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00058"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00073"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00062"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052656">
        <property type="term" value="F:L-isoleucine transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052654">
        <property type="term" value="F:L-leucine transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050048">
        <property type="term" value="F:L-leucine:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052655">
        <property type="term" value="F:L-valine transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01557">
        <property type="entry name" value="BCAT_beta_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018300">
        <property type="entry name" value="Aminotrans_IV_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005786">
        <property type="entry name" value="B_amino_transII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033939">
        <property type="entry name" value="BCAT_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825">
        <property type="entry name" value="PTHR11825"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006468">
        <property type="entry name" value="BCAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="SSF56752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01123">
        <property type="entry name" value="ilvE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00770">
        <property type="entry name" value="AA_TRANSFER_CLASS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 15 17" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="15" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="11 14" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 15 17" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="12">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00005072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR006468-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU004519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AKH85038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="364" mass="39322" checksum="A917FDE0D50B4111" modified="2015-07-22" version="1">MTTIELKPSAHPLSDAEREAILTNPGFGKHFTDHMVTIKWTEGRGWHDAQLQPYAPLTLDPATMALHYGQSIFEGLKAYRQPDGSVRTFRPDANARRFQLSARRLAMPELPVETFVAAIDALVRQDKAWVPGTGEESLYLRPFMFATEVGLGVNSPAHEYLFMVLASPAGAYFTGGIKPVSVWLTEEYVRAAPGGTGEAKCAGNYAGAMAATLQAVQQGCDQVVWLDAVERRWIEEMGGMNLYFVRGEGPEAEVVTPELTGTLLPGITRDSLLTIAAGLGYRTGEVRISKEEWQAGCLDGTISETFACGTAAVITPVGHAKSSTAEWTVADGSMGPVTARLRKALVDVQTGQAADPHGWMHELG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCE0</accession>
    <name>A0A0F7NCE0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AA958_26230</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNQ-509</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018385.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_26230"/>
    <dbReference type="EnsemblBacteria" id="AKH85144">
        <property type="protein sequence ID" value="AKH85144"/>
        <property type="gene ID" value="AA958_26230"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_26230"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5521"/>
    <dbReference type="OrthoDB" id="760677at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="9">
        <location>
            <begin position="61"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="8">
        <location>
            <begin position="171"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="7">
        <location>
            <begin position="283"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AKH85144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="652" mass="71192" checksum="CF767BD1A1CFCEC0" modified="2015-07-22" version="1">MTAPSTRPSVSEKEAREVAEAAREQDWRKPSFAKELFLGRFRLDLIHPHPEPAAEDVARGEEFLSRLRDFCETSIDGAVIERDARIPDETVRGLKEIGAFGMKIDRKYGGLGLTQVYYNKSLALVGTASPAVGALLSAHQSIGVPQPLKIFGTEEQKEEFLPRCARTDISAFLLTEPDVGSDPARLATTAVPDGDGPDADYLLDGVKLWTTNGVVADLLVVMARVPKSEGHRGGITAFVVEAASEGVTVENRNQFMGLRGIENGVTRFHQVRVPAANRIGPEGAGLKIALTTLNTGRLSLPALCVGAGKWCLKIARGWSGAREQWGRPVAEHEAVGAKVSFIAATTFALEAVLDLSSQMADEDRNDIRIEAALAKLYGSEMASLMADELIQIRGGRGYETAESLAARGEKAIPAEQIVRDLRINRIFEGSTEIMHLLIAREAVDAHLKVAGDLIDPQKNLSEKARAGARAGGFYARWLPKLVAGKGQVPRTYGEFHPPGHRDLSTHLRFVERGARRLARSTFYGMSRWQGRMETKQGFLGRVVDIGAELFAMSAACVRAEMLRAAPGRGGHGKEAYELADAFCRQARIRVEELFGRLWTNTDDLDRRVVRQVLDDAYTWLEEGIVDPSGDGPWIAEAEPGPAKKPNLHRPIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-10-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCR2</accession>
    <name>A0A0F7NCR2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_33195</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019500.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86275">
        <property type="protein sequence ID" value="AKH86275"/>
        <property type="gene ID" value="AA958_33195"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_33195"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.7012"/>
    <dbReference type="OrthoDB" id="1439189at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="3"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH86275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="324" mass="34748" checksum="E961FAF5174BB34C" modified="2015-07-22" version="1">MDLELRHLKTIRAIAEEGSLTRAATALGLAQPALSAQLKRIERALGGPLFDRGRHGVRPTALGELVLDRARVLLPGVLELQQDAVRFARAWGGMPRFRLGGTHGPLLGGLIDRVATAHPATPVTTYTRWSVRELAGMVAEGRLDFALIGVCGDSRPPLTDRLVWQNVGTDPVFVMLTAEHPLAGRRQIELRDLAGENWTDVPGDGCFGDCFAAACIRAGFTPASVYETDSASCVHLAQVGRAVGLCRATFPPTPGLATRPLVGHPLSWRHLIGWHPRSPAAGTAAAVTGYARAAHAEAARRSRSYREWLQAHPDFGTAPARVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCV8</accession>
    <name>A0A0F7NCV8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_26595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018445.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH85208">
        <property type="protein sequence ID" value="AKH85208"/>
        <property type="gene ID" value="AA958_26595"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_26595"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5596"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="78" mass="7450" checksum="F2779FF2EE94375B" modified="2015-07-22" version="1">MGVFAKLLRRGGSSGEGQAAKEPAPAAEPPAGEAAATAAQPEAPGEPANAEAAAPAGIPKQQSAEGAADSDAGDEARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7ND98</accession>
    <name>A0A0F7ND98_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3'-phosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_32855</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019443.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_32855"/>
    <dbReference type="EnsemblBacteria" id="AKH86216">
        <property type="protein sequence ID" value="AKH86216"/>
        <property type="gene ID" value="AA958_32855"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_32855"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6941"/>
    <dbReference type="OrthoDB" id="2061599at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014144">
        <property type="entry name" value="LigD_PE_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13298">
        <property type="entry name" value="LigD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02777">
        <property type="entry name" value="LigD_PE_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LigD_N" evidence="2">
        <location>
            <begin position="45"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH86216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="223" mass="23975" checksum="B7AE3E8E30ADBD24" modified="2015-07-22" version="1">MGKRDELRTCREKRHFDRTSEPGGEPAARGEAAPGDADGPAFVVQIHDASTVHFDFRLEVGGVLKSWAVPKGPSTDPHDKRLAIPTEDHPLAYLGFEGVIPEGEYGGGTVIVWDTGTYRPLSHGRRGQPVPFGQAIDDGHAAFELHGRKLCGRYALTRFRGGAPGGGSGEKPMWLLVRTGSGRGTGGTPDPRRARSARSGLTLRQVAESPDAPRWHQDGGRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDD6</accession>
    <name>A0A0F7NDD6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cell division protein SepF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_27620</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018612.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_27620"/>
    <dbReference type="EnsemblBacteria" id="AKH85378">
        <property type="protein sequence ID" value="AKH85378"/>
        <property type="gene ID" value="AA958_27620"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_27620"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5820"/>
    <dbReference type="OrthoDB" id="2064885at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023052">
        <property type="entry name" value="Cell_div_SepF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007561">
        <property type="entry name" value="Cell_div_SepF/SepF-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038594">
        <property type="entry name" value="SepF-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35798">
        <property type="entry name" value="PTHR35798"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04472">
        <property type="entry name" value="SepF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 5" id="KW-0132">Cell division</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0717">Septation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH85378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="123" mass="13634" checksum="AAABCA55E9EFBC0C" modified="2015-07-22" version="1">MTGHDVTDEQWQGLAEVVPLRGNEWPSWTGHQALDDPEVDADQRQFVVIRCQVFADARRVAEYLIAQVPVLLDLTGAEIDVAKRILDFASGVTFGIQSTMHRVDRNVFLLAPLGTEVEPVAGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDG7</accession>
    <name>A0A0F7NDG7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_04320</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the group II decarboxylase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_04320"/>
    <dbReference type="EnsemblBacteria" id="AKH86540">
        <property type="protein sequence ID" value="AKH86540"/>
        <property type="gene ID" value="AA958_04320"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_04320"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.907"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016830">
        <property type="term" value="F:carbon-carbon lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3">
        <location>
            <position position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH86540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="462" mass="48785" checksum="22B24B0810482D32" modified="2015-07-22" version="1">MEAVELVAHHAEAVAEGPVAPAEPDSGRIRDWLAGHDFSGPRPAGEVLAEVTAALRRWGVHATHPRYLGLFVPTPTWWGVAGELVAAGVNPQLAAYEHAPAAVEIERHVLRFLAGRLGLPSAADGSFTTGGAEANLTAVVVALTRHFPAYPNAGLTALRGQPVLYASAESHLAWLKIAQMTGLGRRAVRLVPVDSAGRMDIARLRMLYDGDVAAGRTPFLLVGTAGTTGGGAVDPLPELARLAAAWGLHFHVDAAWAGAAALSDRLRPLLAGVERADSVTVDAHKWLSAPMGAGLFLTAHPGALAESFRVSTGYMPPDSDTAPDPYRTGVQWSRRFAGLKVFLALAAAGRGAFARQVERDTELGNLLARRLAEDGWPRINDSPLPVVCVADPGAEAHGPDRSDAWHAAVVAHVVRGGRAWISRVRLDGRPAIRLCVTSHRTRAHDIETAVAALGEARAATPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDK1</accession>
    <name>A0A0F7NDK1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_06245</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86575">
        <property type="protein sequence ID" value="AKH86575"/>
        <property type="gene ID" value="AA958_06245"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_06245"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1306"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="226"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="250"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="288"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="311"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="1"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH86575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="352" mass="36447" checksum="96A9F9DABBE3E2EF" modified="2015-07-22" version="1">MVTAQGVAAGLGVPFIVAWTRRVNRRVLLTTLLAVLALGNLVTAVSPNYPLILGTRLCMGFASGVFWAIGVSMAMRIVPERHASRAAAVVMSGISIATVVGIPLGTVIEAQTDWRTTFGIWAGLSVLVFAAVAALVPSMPAQNAVSVREVFSLPVENRQLRTVLFIVVFFVLGHFGAYTFVRPYLEDTASASAAFVTTVLIVFGVGGAVGNFVAGYTVNRNLRGTFVIGLVGLLAALLLLRTVGNGEPGAAVALTLWGLSFGAVQLSQVNMTLAAAPETFEAAMSLNTMAYNTCIALGALFGGLFADHVGVTSVIWFGVVLAAASLLLRLGTGRGGKTSDGASEDGLARTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDQ1</accession>
    <name>A0A0F7NDQ1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AA958_09115</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019894.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_09115"/>
    <dbReference type="EnsemblBacteria" id="AKH86635">
        <property type="protein sequence ID" value="AKH86635"/>
        <property type="gene ID" value="AA958_09115"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_09115"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1920"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.101.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036366">
        <property type="entry name" value="PGBDSf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="SSF47090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="1"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="265"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="396"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="424"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="440"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="472"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH86635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="569" mass="57460" checksum="26F13C0F915B9109" modified="2015-07-22" version="1">MGQLGRGGMGTVWRAVDEVLGREVAVKELRAFGEVAAHDAGELRLRMQREARAAARVDHPGVIAVHDVTEHEGRPLIVMELVDGPSLDDVIRERGVLDPAEAAGIGAKVVDALAAAHRAGVLHRDVKPANILLARSGRVVLTDFGIAAMDDPGDDGTTRLTAPGEMVGSIDYLSPERARGDLPGPPSDVWSLGATLYAAVEGMSPFRRSSTWSTISAIVVDPLPEPQRAGALTGALRELMEKDPDRRADALRAGRLLAAVAAGEPLPDPAETMRLGGPLTATGGGTGAGAGGSGGGAGAGGTPTPPGVGGGFGPAPESHTPSMPPEALNAAAGRAAAAPYGQGGRPQFTPHGQGGSPGSADTSPGRRPPRRRRPLVLAGAAVAVAAVAAAAFTVPGWVGSDDGDENAAGADRSSSAPAGDGKQRGDMKPAEEKEDGKESTSPSPSPSVAGTSEPTETPGKTADPTPEPTRPDATSAKPTSGPTTSAPPADPWDSCTYYSGTALTQRGDNGERVVQVQCILHARGYDLGSAGVDGAFGPSTEAAVKKFQGAEGLAVDGQVGPDTWGALRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-12-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDU1</accession>
    <name>A0A0F7NDU1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_33880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019618.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86396">
        <property type="protein sequence ID" value="AKH86396"/>
        <property type="gene ID" value="AA958_33880"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_33880"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.7154"/>
    <dbReference type="OrthoDB" id="892944at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH86396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="229" mass="23862" checksum="8B14A49DA3C40E24" modified="2015-07-22" version="1">MAGFAAPALAAARLLGDDPLAGRLREIAAAHVDNIFGRNPTGRHASYDAPSGTAGFEGVERGWFSEYRGGAGLLEDLPGVLDGSPKNGHYPFNPDQGNIGHTEGWVAFNSAWNASLAWRAADQTGIEVRTRGGAAARVVPRHAKVTVELRAPLNLDAASADRGSVEVRVGDRAVVPLTVTQAARNARMFRAALDLSAVDAGHGDRITVSYGYGPFAVSYAFTAVGGPVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDX4</accession>
    <name>A0A0F7NDX4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_24680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018124.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_24680"/>
    <dbReference type="EnsemblBacteria" id="AKH84872">
        <property type="protein sequence ID" value="AKH84872"/>
        <property type="gene ID" value="AA958_24680"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_24680"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5205"/>
    <dbReference type="OrthoDB" id="486148at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046306">
        <property type="entry name" value="DUF6421"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19985">
        <property type="entry name" value="DUF6421"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH84872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="370" mass="42114" checksum="44D431F07D0CBAA9" modified="2015-07-22" version="1">MDPLNSLCAETDEIRRDLGDRASFRDPEMLARLARRIEEMPGLCREPAVRAFLDDIRDFIPGRRLSAVKEHINTRRDNRLFSLFDASYFPSLRLEFLAYETLPTNPHMADRYASNTMPVNIVARSAGFGSRPVVALFPENHIDGVQEPDDQIFYFIDKFVERHRRITRRMLGPVLAEGSLPLVQKATDTEIELASSWWVRLHEYHHRQGDMPIPEFLPAKKSKPLAGLEELRVDVSGMLALLGDAALPAEPARLTYEYILAERLLRYAVEGIPRPNYDAVASQLLFSYLTEHGGLRLRGGLIHLDRDLPRVLAGFLGEIEAIERRIHQEPVAAVKKRLLEFTHAYTDYDAEAGDYRHIPYFAAVKASLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NE35</accession>
    <name>A0A0F7NE35_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_29800</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018952.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_29800"/>
    <dbReference type="EnsemblBacteria" id="AKH85724">
        <property type="protein sequence ID" value="AKH85724"/>
        <property type="gene ID" value="AA958_29800"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_29800"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6291"/>
    <dbReference type="OrthoDB" id="1584669at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <source>
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    </evidence>
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    </evidence>
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    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH85724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="297" mass="33015" checksum="BA0F3421531FD1E6" modified="2015-07-22" version="1">MTTTLTKPRPQRTVDRERRRRPGPTARRRNWLGGLAGWLWLAVVVVPLYWILITSLKAQSNYYASNPLAPPDEPTLENYELVLESDFISYFVNSVVVTAGAVVPAVTVSFMAAYAIVRGWRLRFLRVVNGLFLMGLAIPLQATAIPVYLIIIKLQLYDSLLALILPSIAFAIPLSVLILANFIRDVPKELFDSMRVDGATEWGTLWRLAAPLTRPAILTVTIFNALTIWNGFLLPLILTQSPSQRTLPLALWTFQGEYGVNIPAVLAAVVLTTLPLIVLYAFGRRQLLSGLTAGFSR</sequence>
</entry>
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        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
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        </source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="307" mass="32877" checksum="CA927134CC921376" modified="2015-07-22" version="1">MAKTATAAKTNGRAVRRPRHRSRQKAAWLFTAPALVAYAVFVLYPMGLTMQYSLYDWDGVGPSTWVGLDNYAQVFTDPELLDTILHAFELILYFCAVPVVLGLAIANTIRGIATTRLALAARTVLFVPQVIPLVAAGITWSWLLASDDLVNQVLSAVGLGGVTRAWLGDFGTALPAVGVIGAWVLLGLCTLLLLAGMSKIDPTLYEAARIDGAGPLREFFSITVPSLRQEIGVCVTVTVIAALASFDIIYISTQGGPGNSTMVPGLQIYRLAFFSREVGLASALAVVLMVLVLACVLPIQRLTREAR</sequence>
</entry>
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    <accession>A0A0F7NEF7</accession>
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    </gene>
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        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Winkler A."/>
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                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
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    </dbReference>
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            <end position="153"/>
        </location>
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    </evidence>
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            <dbReference type="EMBL" id="AKH85087.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="196" mass="20571" checksum="C3062774964CB663" modified="2015-07-22" version="1">MSTTPLVLAAELAAAWAEIQRHHPELPDLAAPESLIGESSSACGAELSFERLLHEAVHGIAAARGVRDTSRAGRYHNRRFLAIAEELGLDHPDEPHPSSGFSLVTLTPAAKKRYRAAGERLRKALRAHDAATAADSPRSFRGPAARHGSSGGGVRVKAVCDCGRNVRVVPSVLAQAPIVCGGCGKPFRIPEPAAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NEI4</accession>
    <name>A0A0F7NEI4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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    </gene>
    <organism evidence="1 2">
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        <lineage>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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                <person name="Winkler A."/>
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                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="AKH86865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="182" mass="18710" checksum="466E3671A9110FC0" modified="2015-07-22" version="1">MPSEAGWAVLRRRPATGPVGLAGGRMRFLIAEGGAAELPGLLDWLEWGGIPLDLSAAPAAVRSWPPTLWLRPPGRAALARLPAVRLPVGTGAGRGGGVVDGEGVGEDADGVGDAGRDAVEMDGDRGDADGGAVPARNRVADRPDLVRLVSAAATACHRLALNVSRSPFRMPRGCSPEHGHAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NEJ4</accession>
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        <submittedName>
            <fullName evidence="2">Monooxygenase</fullName>
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    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="gene ID" value="AA958_30240"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_30240"/>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="6"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="486" mass="51892" checksum="83AC364C1D8CB399" modified="2015-07-22" version="1">MDNHDADVIIVGAGPTGLMLAGELSLHGMSVAVLEKLTEPMRQSRALGFSARTIEEFAQRGLLSRLGDVDVIPVGHFGGVPLDYRVLAGGSYGARGIPQSRTEAMLAGWIGERGVEVRRGVEATGLAQDADGVTLTLADGGSLRARYVVGCDGARSVVRTAAGIDFPGTDPAIELRFADISGVRLRPRFSGEAVPGGMVMVLPLGPDRCRIIYYDRREPLRTSTEPITYAEVTEAFGRLAGEDISGATPHWVSSTTDVSRQAAEYRRGRVFVAGDAAHIHLPIGAQGMSAGVQDAVNLGWKLALVLQDRAPDALLDTYHTERHPVGARILANTLAQRILYLGDDEVTPLRDVFAELTRHDEVQRHLVGMVTGLDIRHDMGPGDHPLLGRRLADAELVRDGSKTTVYELLRTGSGVLLDLSGGPRLRAAAEGWGDRVDVVAAEPGEGLPESTAILVRPDGYIAWIAGTRESTAGLDEALTRWFGPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NEZ2</accession>
    <name>A0A0F7NEZ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_24725</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_24725"/>
    <dbReference type="EnsemblBacteria" id="AKH87020">
        <property type="protein sequence ID" value="AKH87020"/>
        <property type="gene ID" value="AA958_24725"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_24725"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5214"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH87020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="249" mass="27230" checksum="3D47321D3595ABAA" modified="2015-07-22" version="1">MSGGDGAGARAGVIALWAHPRSVSTAFLRMMAERGDVTVVHEPLVLLTDHGEVALPGTGGGTTTVRSYAELLAHLAELGAAGPVFFKDTLEYRYDHLFAHPGSIAGFRHTFIVREPAATIASHHAVKPEFACREVGYEHQWALFELAWKTTGVRPVVVAAERLLADPAGTVAAYCAAVGLPFLPAALTWAPGELPQWRQNRRWHLDASASSGFTAPRSRHRVAVEDDPRLRAYYDHHLPYYQRLVEHAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NF45</accession>
    <name>A0A0F7NF45_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CDP-diacylglycerol--serine O-phosphatidyltransferase</fullName>
            <ecNumber evidence="4">2.7.8.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Phosphatidylserine synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AA958_28615</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a CDP-1,2-diacyl-sn-glycerol + L-serine = a 1,2-diacyl-sn-glycero-3-phospho-L-serine + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16913"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.7.8.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.8" evidence="4"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_28615"/>
    <dbReference type="EnsemblBacteria" id="AKH87090">
        <property type="protein sequence ID" value="AKH87090"/>
        <property type="gene ID" value="AA958_28615"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_28615"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6028"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003882">
        <property type="term" value="F:CDP-diacylglycerol-serine O-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004533">
        <property type="entry name" value="CDP-diaglyc--ser_O-PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00473">
        <property type="entry name" value="pssA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="134"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="171"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH87090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="280" mass="29737" checksum="23B7153BFD438201" modified="2015-07-22" version="1">MIDPETKAGWVPEVDEDDDDMPLSTRLSIADTLTLANATCGFLAVYFTTTGVLVPHLAGEDAGGIARHSAATAVILMLLASVFDLFDGLVARKLRSSAMGAELDNLSDLISFGLAPAYFVLVYGMVADDAHQRVSTVAAVAVVLAVVLRLARFSCVTVRDGVFQGMPSPFGALTVISVVLLELPFVPTLLAIVGVAWLMVSRVEYPKPRGRLAVATLVWIFISMTCLGAWAFDAPNGQLLLQTGCALQIVTAATIPLFATARRVNTFRVGRREARAAAQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFB5</accession>
    <name>A0A0F7NFB5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AA958_32505</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019386.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_32505"/>
    <dbReference type="EnsemblBacteria" id="AKH86159">
        <property type="protein sequence ID" value="AKH86159"/>
        <property type="gene ID" value="AA958_32505"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_32505"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6860"/>
    <dbReference type="OrthoDB" id="692375at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="9">
        <location>
            <begin position="188"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="249"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AKH86159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="482" mass="51260" checksum="27AEB37A6E79B368" modified="2015-07-22" version="1">MSRPAGREPRRLTRWWRRRSLRSRLTVIAATAIAVSVFVAFQVASELLAWELQDTAEDQLRADSRVLATNAERAGLAQVQLPPYPGSGRLVRVILPDGSIRTPAGQPALPPVSERAGRVAQGASADLMESGDSEEDGYLIYTLRAGDGAVQVVRVTDDEPINEFGLGMLLIGLLCVVGGALVGRTVARTGLAPIDRLTAAAVRVAHTRDLDTDIPDEGGGEIRRLIQSINDMLAALRDSRRAQRLLAEDAAHELKTPLTSLRLNVELLIRLDRRGTLDSALPAESRTRLLNDLGAQVAELSTLAAELTDLARGDVSDESTEVLDFANVVVAAATRARSRVPDIEVALDVTSVWVSGRPAALERAVLNLIDNAGKWSPADQPVQVLLRAQGASAVLEVNDAGPGIDAADVPRVFDRFYRADSARALPGSGLGLSIVQRVVDAHGGRATIARSARGGALLRVDLPAAAPPAITRLTSGDDTAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFL7</accession>
    <name>A0A0F7NFL7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transketolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_32315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019360.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_32315"/>
    <dbReference type="EnsemblBacteria" id="AKH86133">
        <property type="protein sequence ID" value="AKH86133"/>
        <property type="gene ID" value="AA958_32315"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_32315"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6822"/>
    <dbReference type="OrthoDB" id="1543182at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TRANSKETOLASE_1" evidence="1">
        <location>
            <begin position="31"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="237" mass="24793" checksum="895F4F0D9241E868" modified="2015-07-22" version="1">MTTSTAVRQRTPAGYDDLPRLMGLMTGDEKHGPAATSTLDALWVLYDRVLRVTPGTAEAPDRDRFLLSKGHGPMAYYAVLAAKGFLPADWLPGFGAYDSPLGHHPDRTLLPGVEIGSGSLGHGLPLAVGTALGLRARGLSEPRVWVLVGDAELDEGSNHEALAYAGATGLDSLHTLVIDNASASHALPGGIAARFEAAGWSTATVDGRDHEALYAAFTAPHPGRARAVVARVEPAYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFP7</accession>
    <name>A0A0F7NFP7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Protein meaA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AA958_28640</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(R)-methylmalonyl-CoA = succinyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:22888"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:57326"/>
            <dbReference type="EC" id="5.4.99.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Metabolic intermediate metabolism; propanoyl-CoA degradation; succinyl-CoA from propanoyl-CoA: step 3/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Heterodimer of an alpha and a beta chain.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018786.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_28640"/>
    <dbReference type="EnsemblBacteria" id="AKH85552">
        <property type="protein sequence ID" value="AKH85552"/>
        <property type="gene ID" value="AA958_28640"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_28640"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6034"/>
    <dbReference type="OrthoDB" id="154460at2"/>
    <dbReference type="UniPathway" id="UPA00945">
        <property type="reaction ID" value="UER00910"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004494">
        <property type="term" value="F:methylmalonyl-CoA mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006159">
        <property type="entry name" value="Acid_CoA_mut_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016176">
        <property type="entry name" value="Cbl-dep_enz_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006099">
        <property type="entry name" value="MeMalonylCoA_mutase_a/b_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006098">
        <property type="entry name" value="MMCoA_mutase_a_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01642">
        <property type="entry name" value="MM_CoA_mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51703">
        <property type="entry name" value="SSF51703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="SSF52242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00640">
        <property type="entry name" value="acid_CoA_mut_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00641">
        <property type="entry name" value="acid_CoA_mut_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0846">Cobalamin</keyword>
    <keyword evidence="8" id="KW-0170">Cobalt</keyword>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B12-binding" evidence="9">
        <location>
            <begin position="535"/>
            <end position="664"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AKH85552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="673" mass="72250" checksum="10F2728EB188CCD6" modified="2015-07-22" version="1">MAAKDRPWLMRTYAGHSTAEASNELYRRNLAKGQTGLSVAFDLPTQTGYDPDHVLARGEVGRVGVPVSHLGDMRRLFAGIPLERTNTSMTINATAMWLLALYQVVAEEQGLDEAGVAKLAGTTQNDIVKEYLSRGTYVFPPGPSLRLTTDTIAYTVGKMPKWNPINICSYHLQEAGATPVQEIAYAMATATAVLDAVRDSGQVPPEKLGDVVGRISFFVNAGVRFVEEMCKMRAFTRIWDTLTRERYGIEDPRQRRFRYGVQVNSLGLTEAQPENNVQRIVLEMLAVTLSKDARARAVQLPAWNEALGLPRPWDQQWSLRIQQVLAYESDLLEHPDLFDGSHVVEARVAGLVEGATAEMAHIERLGGAVAAVESGYLKARLVASHAERRARIESGEEKIVGVNCHTETEPSPLTADLDAAIMTVDPDVEARVVAAMHEWRLSRDEPRVQRALTALKAAAAGTANLMPASLECARAGATTGEWAWALRDVFGEFRAPTGVGGAPVAVPAAETGGEAALTAVRYRAAATAAELGSGRLRLLVGKPGLDGHSNGAEQIAVRARDAGFEVVYQGIRLTPEQIAAAAVAEDVHCVGLSILSGSHAELVPDVLDLLRRAGAGDVPVVVGGIIPAADAEALRAAGVAAVFTPKDFGITQIIGRIVDEIRLANKLDQEVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NG43</accession>
    <name>A0A0F7NG43_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_29695</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018940.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_29695"/>
    <dbReference type="EnsemblBacteria" id="AKH85712">
        <property type="protein sequence ID" value="AKH85712"/>
        <property type="gene ID" value="AA958_29695"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_29695"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6269"/>
    <dbReference type="OrthoDB" id="1619224at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="300"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="104"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH85712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="331" mass="35908" checksum="9235F0440954CA01" modified="2015-07-22" version="1">METTTTTAPQAAGSGSQASGPAEPSARRRGGRTAQERSVRWAGRAFLAPLLVYLLAFYAYPLFRNVDLSLHEYTVRSFVQGGAEFTGLANYRDVIGADAFVPALRNTLVFTFVSIAAQYAIGLALAVFFRNGFRLSGLLRGMFLVPWLLPLIVSGSTWSWMLNSDNGIVNSVLEAFGIGQINWLTDPGWALTSVIIANIWLGIPFNLVILYSGLQNIPDELYEAAALDGASAWQQFRRVTFPLLRPVSAITLLLGLVYTLKVVDVIWIMTTGGPGTSSTTLAVWSYREAFGTGLPDFSPAATAGNLLIFLALAFGLLYIRLEGRARRGDPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NGU1</accession>
    <name>A0A0F7NGU1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_31235</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019175.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_31235"/>
    <dbReference type="EnsemblBacteria" id="AKH85947">
        <property type="protein sequence ID" value="AKH85947"/>
        <property type="gene ID" value="AA958_31235"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_31235"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6600"/>
    <dbReference type="OrthoDB" id="1832232at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="1"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="30"/>
            <end position="37"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH85947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="247" mass="26621" checksum="334441D6EEC2C474" modified="2015-07-22" version="1">MSFARREQEQTVLENLDLDITPGSFVTLLGPSGCGKSTLLKILGGILEPTEGTVRIGGQPAADAVKDRVIGLVPQRPALLPWKSALQNASMLRQLAADERAAEAAPAARRALELVGLAAAEDKLPHELSGGMAQRVSIARALAMDPAILLMDEPFGALDAITRDEMNLKLAEIWATTGKTVVFVTHSISEAVFLSDTVHVMGLDRGRFLETLDVALPRPRTREVLDDPVFTEYTGRLRGHLEPKATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NGW4</accession>
    <name>A0A0F7NGW4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AA958_10785</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019948.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_10785"/>
    <dbReference type="EnsemblBacteria" id="AKH86679">
        <property type="protein sequence ID" value="AKH86679"/>
        <property type="gene ID" value="AA958_10785"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_10785"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2268"/>
    <dbReference type="OrthoDB" id="1974702at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018929">
        <property type="entry name" value="DUF2510"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010432">
        <property type="entry name" value="RDD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10708">
        <property type="entry name" value="DUF2510"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06271">
        <property type="entry name" value="RDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="440"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="545"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2510" evidence="8">
        <location>
            <begin position="15"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="RDD" evidence="7">
        <location>
            <begin position="429"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="40"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="157"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="92"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="181"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="304"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="370"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH86679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="587" mass="59505" checksum="CC0DE8B72B1C65B3" modified="2015-07-22" version="1">MSAPTPPSGGGIPGPGYYPDPSIPGYVRYWNGAAWVPGTSRRAQEGEEQLAADAQEIADAESASAGGAEGADAAPAEPAASGPSLSETGPVFLDEEEPRDSVPAPRGRHARGSDDADDVRDAAERAASDEPPAGEPADAQGAWQAVDVVDVAERADSRVAWGAQDQPALTVPAELGGGTPEPGRTEEEPRLPAARRAEDAGAADGGAGQEGGQAAPGPYEQDRPGVPLGRDPRVGGGSWGEQVRRLSGPAPVPAPGTPEETHEEAGPGAGSGAGSGAAASGFGPGAAGSGAADPRQTPGAYVPAPTTPEVPGALPAPTTPDLPQARPAPTAPDVPVAPPPTPTTPELPQPRPAPPQLAPQGGHAAPPLTPAARTAPPSTPQPPPAAQLPERPAARAELPQGGGGEPPVVPWRPPSGDPFLSAAQGTAPPAGLGRRLGARFVDALLVGGVLAAVAVPLVSKSVDHVQDKIDAAEESGKTVTVWLIDGTTGPYLALVLGLFLVLGLVVEALPTAKWGRTPGKRLFGVRVLDIESQDPPATGSALRRWLTYAVFLLLPFIGLLNVVWCAFDKPWRQCWHDKAGRTYVARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NH48</accession>
    <name>A0A0F7NH48_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptide hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_14660</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_14660"/>
    <dbReference type="EnsemblBacteria" id="AKH86769">
        <property type="protein sequence ID" value="AKH86769"/>
        <property type="gene ID" value="AA958_14660"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_14660"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3088"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S9" evidence="3">
        <location>
            <begin position="417"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="619"/>
            <end position="642"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH86769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="642" mass="68964" checksum="0902D7BD6EEF5B5C" modified="2015-07-22" version="1">MGAQADGGEAGAGSGSAADAAPAWERRFRAPRISLPGWAEDAPHRALYVSNVTGTFELYAWDRRTGGVRQVTDRPNGTTDGALTPDGEWVWWFCDTDGDEFGVWRRQPFAGAAPGQDRAAAPGLPAAYSAGLALGRDGTAVVGRSTEETGTTIHLVRPGGETSEIYRHRESAGVGDLSHDGRLLAIEHTEHGDAMHAALRVLRLGGAPGGDPAVAELDDTKGGREELGLEVLGFAPVAGDTRLLVGHQRRGRWEPMIWDPVTGRSRELELDLPGDVSAEWYPDGSALLVLHTYQARSELWRYGLEGADSGAMTRIETPPGTISGATARPDGAVEFHWSSGAEPPQVRSAQGAVVLQPPGRAAPRSVPVEDAWVDGPGGRIHALVQRPPGEGPFPCLFDVHGGPTWQDSDAFAAGPAAWVDHGFAVVRVNYRGSTGYGREWTDALKHRVGLIELEDIAAVREWAVASGLADPERLVIGGGSWGGYLALLALGTQPDVWALGLSAVPVADYVAAYEDEMEALKAMDRTLMGGSPEEVPERYAASSPLTYVDKVRAPVFVSAGVNDPRCPIRQVENYVGRLAERGHPHEVYRYDAGHGSLVVDERIKQLGLELDFVRRHLLPDLAPQPQQPDPEPRDRPRQDRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NHP6</accession>
    <name>A0A0F7NHP6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA polymerase sigma factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AA958_21835</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_21835"/>
    <dbReference type="EnsemblBacteria" id="AKH86954">
        <property type="protein sequence ID" value="AKH86954"/>
        <property type="gene ID" value="AA958_21835"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_21835"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4598"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="RNA_pol_sigma-70-like"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SIGMA70_ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="7">
        <location>
            <begin position="16"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="8">
        <location>
            <begin position="119"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="186"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU000716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH86954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="214" mass="22129" checksum="7154CA3E78D18218" modified="2015-07-22" version="1">MVARVRNGETEAYAELVRAHAETAHRLALLLGAGAEAEDVVQNAFIKAYRALGGFRDGAAFRPWLLRIVANETKNTVRAAARRRAATERAGALAGATGAGGAGVAAEDLAGRALAVERREELVTALRALRERHREVVIHRYLLDLDEAETAAALGVARGTVKSRLSRALRELARLLGEDGGLRDGAAGGVRGRGGRGRGGAAAGEPEGGGAGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NHQ6</accession>
    <name>A0A0F7NHQ6_9ACTN</name>
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        <submittedName>
            <fullName evidence="6">LacI family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_33235</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_33235"/>
    <dbReference type="EnsemblBacteria" id="AKH86282">
        <property type="protein sequence ID" value="AKH86282"/>
        <property type="gene ID" value="AA958_33235"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_33235"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.7020"/>
    <dbReference type="OrthoDB" id="664909at2"/>
    <dbReference type="Proteomes" id="UP000034283">
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
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    <dbReference type="Pfam" id="PF00356">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="5">
        <location>
            <begin position="7"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="309"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH86282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="354" mass="36393" checksum="9F4A6E7F0E2DA2CF" modified="2015-07-22" version="1">MSSGGPPTIVSIAERAGVSIASVSRVLNGLGARPETEDRVRRAAAELGYVPNAVARSLKDGHTRQLTFAVPDIGNPVYVAMVREIQAVAKAAGYRLLLHSTDADVAEELGVVRSLADRTSDGLVLVPIRITPEHVEALTAAPGPVVVIGSLPDGVPVDAVQADSVTGAELAVRHLVETGRRRIAFVNGPVDTVPGGNRGRGYRAALAACGIPYDPGLVAATEFGVGAGARATARLLDARPGLDAVFCANDQLAIGAARALHARGRRIPEDTAVAGMDDSELAVAAWPPLTSVDLGAGERGRRAARMLLERLGPQDGEPVPARRTTAAPRLVVRGSTSPGASPAGSDEQEGAKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NHV1</accession>
    <name>A0A0F7NHV1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_33515</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019554.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_33515"/>
    <dbReference type="EnsemblBacteria" id="AKH86332">
        <property type="protein sequence ID" value="AKH86332"/>
        <property type="gene ID" value="AA958_33515"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_33515"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.7078"/>
    <dbReference type="OrthoDB" id="1180629at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH86332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="342" mass="35817" checksum="1D69BE65E5BE0753" modified="2015-07-22" version="1">MFADEKALEERLATPSPGLTGDMAKLEGDLLVLGAGGKMGPSLCRLARRALDAAGRTDVAVHAVSRWSDPAAAERLRAAGVRTVAADLMDPDAGLAALPDAGNLVFMVGAKFGSAGAPSHAWAVNAGLPERVARRWTGARVAAFSTGNVYPLVSVGTGGSAEPDPVGPVGEYAMSCLGRERLFAHAALARGTKVALLRLNYAVDLRYGVLADIAQRVHAGAPVDVTTGHVNVVWQGYANEVALRALLHARDGEPFTLNVTGPETAAVRRLAHRFGAEFGTEPVFEGTEAPTALLSDAAACHALFGYPDVPLGTLVGWQADWLRRGLPLSGKPTKFQVRDGRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NHW0</accession>
    <name>A0A0F7NHW0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptide ABC transporter ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_26335</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020423.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_26335"/>
    <dbReference type="EnsemblBacteria" id="AKH87044">
        <property type="protein sequence ID" value="AKH87044"/>
        <property type="gene ID" value="AA958_26335"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_26335"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5544"/>
    <dbReference type="OrthoDB" id="1303270at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="7"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH87044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="324" mass="33672" checksum="DA6063EAF6FFFC0D" modified="2015-07-22" version="1">MLAADGLRVVFPGRHGAPAARAVDGVNLAVGQGEIVALVGESGCGKTTLARALLGLVRPTAGTVSFRGSPLAYGSRALKAYRRRVQLVLQDPSGSLNPRHTVYDAVAEGLRIHGHRGDERAVVASALARAGLRPPERFFLRYPHELSGGQRQRVVIAGALVLDPELIVADEPVASLDASVRGEILALLLRLRDHMGLSALVVTHDLGLAWNIADRVAVMYLGRIVEAGPVEEVLTAPRHPYTKALLSVLPESGTAPVVLTGEPPDPARIPGGCRFHVRCQQLASGEAASAGVADACRGTDLPVLGGARPGVACHLAGTAAAPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NI57</accession>
    <name>A0A0F7NI57_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_00080</name>
        <name evidence="2" type="ORF">AA958_34180</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86452">
        <property type="protein sequence ID" value="AKH86452"/>
        <property type="gene ID" value="AA958_00080"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH87226">
        <property type="protein sequence ID" value="AKH87226"/>
        <property type="gene ID" value="AA958_34180"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_00080"/>
    <dbReference type="KEGG" id="strc:AA958_34180"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.17"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH86452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH87226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="176" mass="19940" checksum="D1FB371EC9B44D46" modified="2015-07-22" version="1">MDRPADGRPPSADVQARLLLLIDVFSETKASKGIEGRMKLAKLDFLLRYPGHFRKLMSVRRPGTDIGEDPWLTGAIEQSMIRYRYGPWDSTYYALLGALTGKGLIEPKHEDAVASYRTTQAGHDVARALAETESWRPVRERALLLRRHFNLSGTTLKDLIYETFPDIVEADWGTHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NJ92</accession>
    <name>A0A0F7NJ92_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PBPb domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_17440</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_17440"/>
    <dbReference type="EnsemblBacteria" id="AKH86847">
        <property type="protein sequence ID" value="AKH86847"/>
        <property type="gene ID" value="AA958_17440"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_17440"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3669"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="PBPb" evidence="3">
        <location>
            <begin position="37"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="16"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH86847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="278" mass="29210" checksum="5B717AFCCFD756AB" modified="2015-07-22" version="1">MLPSGGDGATAGDSPTECATDPSPAGSGSGGGTGRKSLTIGIMPDQSTMSYCDRDGNYAGFEVDVARYVAGELGVEVEDITWREVSAAERRDVLVRGEVDFVVAGYGITDATKEEVDFAGPYLSARQDLLMRADERVRKVTDLNGMKLCSVTGSTSAQVVKEGGAPGADLTERAAYTECLTALDREEVDALTTDDSLLAGYAAWSGNSSDYRLAGLELSAEHFYGVGVPEGETELRDDIDKAIEQMIADGSWARSAATFLEGVANYDAEPPEQAATTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A097H0Z3</accession>
    <name>A0A097H0Z3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cnq911</name>
        <name evidence="3" type="ORF">AA958_29950</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="ChemBioChem" volume="15" first="2385" last="2392">
            <title>A Membrane-Bound Prenyltransferase Catalyzes the O-Prenylation of 1,6-Dihydroxyphenazine in the Marine Bacterium Streptomyces sp. CNQ-509.</title>
            <authorList>
                <person name="Zeyhle P."/>
                <person name="Bauer J.S."/>
                <person name="Steimle M."/>
                <person name="Leipoldt F."/>
                <person name="Rosch M."/>
                <person name="Kalinowski J."/>
                <person name="Gross H."/>
                <person name="Heide L."/>
            </authorList>
            <dbReference type="PubMed" id="25224759"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CNQ-509</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KJ451628">
        <property type="protein sequence ID" value="AIT42140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018975.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_29950"/>
    <dbReference type="EnsemblBacteria" id="AKH85747">
        <property type="protein sequence ID" value="AKH85747"/>
        <property type="gene ID" value="AA958_29950"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_29950"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6324"/>
    <dbReference type="OrthoDB" id="504558at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="9"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIT42140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH85747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="404" mass="43471" checksum="1E17693BBA77394C" modified="2015-01-07" version="1">MTETHSPGIVIAGAGIGGLAAALALHARGLEVTLLEEAEEIRPLGVGINIQPAAIGELTALGLGGRLAATGIATREHRYLDHQGRTIWSEARGIAAGNDFPQYSIHRGELQMMLLDAVRSRLGADAIRTATRVRGFEQDTDGVRVHISSRSGGESGIDADALIAGDGMHSVIRAQLHPEGSPLRRTPVRMWRGLTEIPEFIDGRTMIIASDDRSNRMVAYPCSRPHAERGKVLLNWVCLAADPEWQGEVQLSPGRFEDLLPHFADWDFGWLDVHTALKSSGQLMHHVMADRDPLPSWGEHRVTLLGDAAHPMYPIGANGGTQAILDGVALAAELADAGGDVPAAFKRYESVRLPAANAIVEANRSMDHSERTLAETSADEMAAGLETITTDYQDVVDRASATRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MXS3</accession>
    <name>A0A0F7MXS3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GAF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_01425</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CdaR family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014410.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_01425"/>
    <dbReference type="EnsemblBacteria" id="AKH81045">
        <property type="protein sequence ID" value="AKH81045"/>
        <property type="gene ID" value="AA958_01425"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_01425"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.314"/>
    <dbReference type="OrthoDB" id="1439158at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041522">
        <property type="entry name" value="CdaR_GGDEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17853">
        <property type="entry name" value="GGDEF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAF" evidence="2">
        <location>
            <begin position="89"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH81045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="660" mass="70426" checksum="7DBFFA380D9EF937" modified="2015-07-22" version="1">MGTDLPATAHAAGTAGMAAERLLRLLRDGASRREYEELLAGAQGEAAVALRPLVDDALAVRAQLEERRRREAELAALYETAGDLSSLRDLEAVLQAIVRRVRQLIGTDAAYLMLNDDDRGDTYMRVTDGIRTDSFKQVRLAMGAGLGGLVAKTGVPYHTPDYLNDPRFDHTIDDAVGGEGVTAIQGVPLSLGDRVIGVLFAANRRARPFSQAEVALLVSLANHAAIAIENATLFQDVRRTVDELTEANAVIQAHSRSIERAAALHERLTTIVLDGGGLADVAETLAEVLGGSLLVLDPRGRTMAAAGTDPVVEQARAEGALPDSCPAARAVREARVLSTDARRTRRLPAADGGGAACATPVVAGGEVQGVLLLLCRRIGADDVRLLERAAMVTALLLLGERTVAEAEHRLRGEFLDDLLSSPHRDPEGLHRRAALMGIAHGRPHTVLTARSRDGASRRRIADAAAPYAARHGGLAGEHHGDVVVLLDGDTDPGAQARALAEHLRRTLDAAVTVGAAAAAAGLEAIVEAHPDAVRCLDVLLALDRDGEGASPDELGVYGLLFHQTGRDELRRFVRRTLGPVLEYDERRSGDLARTMTTYFACDANLTRTAAALYVHVNTLYQRIDRITSLLGPQWRHGDHRLQTHLAVKVHAILSASAEPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MYN8</accession>
    <name>A0A0F7MYN8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_00150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="AKH80841"/>
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    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_00150"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.34"/>
    <dbReference type="Proteomes" id="UP000034283">
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    </dbReference>
    <dbReference type="InterPro" id="IPR025668">
        <property type="entry name" value="Tnp_DDE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13586">
        <property type="entry name" value="DDE_Tnp_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="21"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH80841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="124" mass="14081" checksum="1C482EC47F308BC0" modified="2015-07-22" version="1">MLKKVRVRGPVGRPRTRPGTVAADKAYSSRGTRAHLRKRRIKAVIPEKKDQAANRKKKGSAGGRPLSHDADLYKERNTVERLINKLKAWRGIATRYDKSPASYRAGLHLRASVIWLKDLTRTTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MYU1</accession>
    <name>A0A0F7MYU1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MoxR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_03565</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014773.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_03565"/>
    <dbReference type="EnsemblBacteria" id="AKH81415">
        <property type="protein sequence ID" value="AKH81415"/>
        <property type="gene ID" value="AA958_03565"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_03565"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.751"/>
    <dbReference type="OrthoDB" id="848990at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002881">
        <property type="entry name" value="DUF58"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01882">
        <property type="entry name" value="DUF58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF58" evidence="2">
        <location>
            <begin position="57"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH81415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="319" mass="34575" checksum="4622351B328067B0" modified="2015-07-22" version="1">MSATGSAAGATARGVPGSPSLGELTPEQALQHLRLLFTRRPDGLLQGDLTALVPGPGGEPDESRPYAPGVDDVRRMDWNATARTTVPHVRMTLADRELTTWIVLDASASMDFGTGRMEKRDLAVGAAAAVAFLTERAGNRLGAQLVRPDGIQRIPARGGRRHLMRVLRTALERPRVPAGPQTHTLAEAVAALQRAERRRGLVAVVSDFLEPGWEQPLRALARRHQVLAVEIVDPRELELPPVGLLTVVDPESGRRREIPTYSKRLRERYAAAAAEQRAAIARALRAAGAARLPLRTDRDWVRDIARYAAAQRRGTGGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MZK2</accession>
    <name>A0A0F7MZK2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">LuxR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_05430</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_05430"/>
    <dbReference type="EnsemblBacteria" id="AKH81730">
        <property type="protein sequence ID" value="AKH81730"/>
        <property type="gene ID" value="AA958_05430"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_05430"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1139"/>
    <dbReference type="OrthoDB" id="1687028at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="5">
        <location>
            <begin position="34"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="4">
        <location>
            <begin position="175"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH81730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="245" mass="26197" checksum="A6F9BBC27E244E7E" modified="2015-07-22" version="1">MNEPREDAEEPPRAPRSGAGEPHTAAQPGSRPLRIVLADDERMVRTALRAILSAEDDLAVVGEAATGAEAVSVVRRLEPDVVLMDVRMPEIDGIRATEQLLRTMPVPPRIIVVTTFENDSYVYDALRAGAAGFLLKRAGAADLVQAVRLVARTDSLLYPAAVRALAAAHARTRRTTALRARLTDREADVLRLMARGLTNAEIAARLDIGAATVKSHVAALLAKLGARDRTQAVIAAYESGFVTPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MZX4</accession>
    <name>A0A0F7MZX4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase</fullName>
            <ecNumber evidence="2">2.5.1.145</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">lgt</name>
        <name evidence="4" type="ORF">AA958_06135</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-cysteinyl-[prolipoprotein] = H(+) + S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[prolipoprotein] + sn-glycerol 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:56712"/>
            <dbReference type="Rhea" id="RHEA-COMP:14679"/>
            <dbReference type="Rhea" id="RHEA-COMP:14680"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57685"/>
            <dbReference type="ChEBI" id="CHEBI:64716"/>
            <dbReference type="ChEBI" id="CHEBI:140658"/>
            <dbReference type="EC" id="2.5.1.145"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; lipoprotein biosynthesis (diacylglyceryl transfer).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the Lgt family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.145" evidence="2"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015208.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_06135"/>
    <dbReference type="EnsemblBacteria" id="AKH81855">
        <property type="protein sequence ID" value="AKH81855"/>
        <property type="gene ID" value="AA958_06135"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_06135"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1282"/>
    <dbReference type="OrthoDB" id="435911at2"/>
    <dbReference type="UniPathway" id="UPA00664"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008961">
        <property type="term" value="F:phosphatidylglycerol-prolipoprotein diacylglyceryl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042158">
        <property type="term" value="P:lipoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01147">
        <property type="entry name" value="Lgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001640">
        <property type="entry name" value="Lgt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30589">
        <property type="entry name" value="PTHR30589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01790">
        <property type="entry name" value="LGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00544">
        <property type="entry name" value="lgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01311">
        <property type="entry name" value="LGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="180"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="239"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="265"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)</name>
            <dbReference type="ChEBI" id="CHEBI:64716"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH81855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="376" mass="39220" checksum="B458177E71895272" modified="2015-07-22" version="1">MDLAYIPSPSEGVWHLGPLPLRGYALAILLGIFVAIWLGGRRWIARGGRAGTVADIAIWAVPFGLVGGRLYHVVTTYEPYFGEGGDWVKAFEIWEGGLGIWGAIAMGALGAWIGCRRRGIPIPAYADAVAPGIALAQALGRWGNWFNQELYGKQTDVPWAVEIDAEYSVTGTAETFHPTFLYESLWCIGVALLVIWADRRFRLGHGRAFALYVAGYTAGRGWIEYLRVDEAHEVLGLRLNVWTSILVFAAAVLYIVVSAKKRPGREEVVERAAHDESGAPGKDAPGAPGKDAPGAPGKDAPGAPGKDAPGAPGKDAPGAAGKAGADAKDGEPGEAEGPDGPGDASGAAGEQEPATAGAAEAKAAGDAPAGERGRHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N054</accession>
    <name>A0A0F7N054_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">S-adenosylmethionine synthase</fullName>
            <shortName evidence="11">AdoMet synthase</shortName>
            <ecNumber evidence="11">2.5.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">MAT</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Methionine adenosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">metK</name>
        <name evidence="17" type="ORF">AA958_03075</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>ATP + H2O + L-methionine = diphosphate + phosphate + S-adenosyl-L-methionine</text>
            <dbReference type="Rhea" id="RHEA:21080"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.5.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="11">Binds 1 potassium ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 2 divalent ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homotetramer; dimer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11 12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11 13">Belongs to the AdoMet synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.6" evidence="11"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018836703.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_03075"/>
    <dbReference type="EnsemblBacteria" id="AKH81326">
        <property type="protein sequence ID" value="AKH81326"/>
        <property type="gene ID" value="AA958_03075"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_03075"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.656"/>
    <dbReference type="OrthoDB" id="1024388at2"/>
    <dbReference type="UniPathway" id="UPA00315">
        <property type="reaction ID" value="UER00080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004478">
        <property type="term" value="F:methionine adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006556">
        <property type="term" value="P:S-adenosylmethionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00086">
        <property type="entry name" value="S_AdoMet_synth1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022631">
        <property type="entry name" value="ADOMET_SYNTHASE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022630">
        <property type="entry name" value="S-AdoMet_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022629">
        <property type="entry name" value="S-AdoMet_synt_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022628">
        <property type="entry name" value="S-AdoMet_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002133">
        <property type="entry name" value="S-AdoMet_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022636">
        <property type="entry name" value="S-AdoMet_synthetase_sfam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11964">
        <property type="entry name" value="PTHR11964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02773">
        <property type="entry name" value="S-AdoMet_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02772">
        <property type="entry name" value="S-AdoMet_synt_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00438">
        <property type="entry name" value="S-AdoMet_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000497">
        <property type="entry name" value="MAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55973">
        <property type="entry name" value="SSF55973"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01034">
        <property type="entry name" value="metK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00376">
        <property type="entry name" value="ADOMET_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00377">
        <property type="entry name" value="ADOMET_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 11 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 11" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="10 11 12" id="KW-0630">Potassium</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="S-AdoMet_synt_N" evidence="14">
        <location>
            <begin position="4"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="S-AdoMet_synt_M" evidence="15">
        <location>
            <begin position="126"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="S-AdoMet_synt_C" evidence="16">
        <location>
            <begin position="251"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Flexible loop" evidence="11">
        <location>
            <begin position="99"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="175"/>
            <end position="177"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="248"/>
            <end position="249"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="257"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="263"/>
            <end position="264"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AKH81326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="403" mass="43182" checksum="16D94708BABA3B6F" modified="2015-07-22" version="1">MSRRLFTSESVTEGHPDKIADQISDAILDALLKDDPHSRVAVETLITTGQVHVAGEVTTSGYADIATLVRNKILEIGYDSSKKGFDGASCGVSVSIGAQSPDIAQGVDTAYESRVEGSGGDDLDLQGAGDQGLMFGYACDETPELMPLPIHLAHRLSARLSEVRKNGTIPYLRPDGKTQVTIEYNGDKAARLDTVVVSSQHASDIDLDSLLTPDIREFVVEPELKALLDDGIKLDTEGYRLLVNPTGRFEIGGPMGDAGLTGRKIIIDTYGGMARHGGGAFSGKDPSKVDRSAAYAMRWVAKNVVAAGLASRCEVQVAYAIGKAEPVGLFVETFGTATVDVEKIENAISEVFDLRPAALIRDLDLLRPIYSQTAAYGHFGRPLADFTWERTDRVDALRKAAGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0K1</accession>
    <name>A0A0F7N0K1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_04110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014866.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_04110"/>
    <dbReference type="EnsemblBacteria" id="AKH81511">
        <property type="protein sequence ID" value="AKH81511"/>
        <property type="gene ID" value="AA958_04110"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_04110"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.863"/>
    <dbReference type="OrthoDB" id="1378040at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519644" evidence="1">
        <location>
            <begin position="35"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_4" evidence="2">
        <location>
            <begin position="39"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH81511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="348" mass="37464" checksum="C35A79510636E995" modified="2015-07-22" version="1">MLTRSLRTTAVAACTTLLALAPLTACNRGNDAAGADGQVGIDMPRTDTDFWNSYHQYLNKGVSDGVVDALPITNSQNDIGKLVANVQAFTDQGADAVIMAPQDTGAVASTLERLAEEDIPVVSVDTRPDKGDVYMVVRADNEAYGIKACEYLGEQLKGKGKVVEFQGDLASINGRDRSVAFKNCMDEKYPDMQVFELPTEWKGDVASAKLQSVLAKEKSIDGIYMQAGGAFLQPTLALLEQKGKLKPAGEDGHITIVSNDGIPEELDAIRSGKIDATVSQPADLYAEYALFYAQQALKGKEFKPGKTDHGSEIVKIPNGLEDQLPAPLVTKENVDDPELWANQLEKQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0P5</accession>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">AA958_04435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81561.1"/>
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AKH81561">
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        <property type="gene ID" value="AA958_04435"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_04435"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="124"/>
        </location>
    </feature>
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        <location>
            <begin position="220"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="363" mass="37488" checksum="8F29417392ABF22D" modified="2015-07-22" version="1">MPRLRSARRAPLPPRRAPRPARPTPRLSRLPRSAHLAGAAATVLVLSVTAASCALPGQGGSASAADAAAELVLQPVADRGHDPFTPSTATPDGAAPSPSRTAATPDSPPPAEPSRHQSVPGGKAGLYGGVRNVASCDVDKQIAFLGRDAGKQAAFARTLRVDEGDLPGFLRELTSVLLRSDTRLTGHGFADGEASPFQSVLQAGTAVMVDDKGVPRVRCASGSPLTAPEKLSGNDRYGGTGWRGYRPSRTVVVTPVQQALSRLVIVDVNTDLWFERPVGARPGEDRKLPQPPRDHFNPPSPSGSRSPSAEPTGSPGPTTEGPSEGPGTESGEPSTAPPLPGGIDEEEDHERVSAGESSGASAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0Q0</accession>
    <name>A0A0F7N0Q0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptide ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_04485</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_04485"/>
    <dbReference type="EnsemblBacteria" id="AKH81571">
        <property type="protein sequence ID" value="AKH81571"/>
        <property type="gene ID" value="AA958_04485"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_04485"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.946"/>
    <dbReference type="OrthoDB" id="1303270at2"/>
    <dbReference type="Proteomes" id="UP000034283">
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    </dbReference>
    <dbReference type="GO" id="GO:0005524">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <dbReference type="InterPro" id="IPR027417">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="39"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="79"/>
            <end position="86"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH81571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="379" mass="39915" checksum="29FC67103A94B8E1" modified="2015-07-22" version="1">MSAKDSGGPGSIGELAGEPLVEGDGLVEGGGAPPALVTVRNAHVVHRARTGGLFARDRVYALTGADLTIAAGETVGVVGESGCGKSTLAKVLVGVEEPTAGTVEFRGRDIWKMDGGERRTAIGTGAGMIFQDPSTALNRRLPIRQILRDPLDVHHRGTAAQRTERVRELMALVGLPPVLADALPGQLSGGQRQRVAIARALALEPDLVVADEPTSALDVSVRAQILNLLLDLKERLNLALVFVSHDIQTVRRMSDRVITMYLGRIVEEAPAVALGSGGDSPAEHSTDTARHPYTRALFSATPGLLDPIDPIPLAGPVPSATRPPSGCPFRTRCWKATAECAAAMPEVTQAAQSHRFRCHHPVAAGESTRDLVIQAKESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0Q9</accession>
    <name>A0A0F7N0Q9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_08200</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015565.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_08200"/>
    <dbReference type="EnsemblBacteria" id="AKH82215">
        <property type="protein sequence ID" value="AKH82215"/>
        <property type="gene ID" value="AA958_08200"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_08200"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1730"/>
    <dbReference type="OrthoDB" id="1247435at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
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        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
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    </dbReference>
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            <begin position="1"/>
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        </location>
    </feature>
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            <begin position="27"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH_hydro" evidence="3">
        <location>
            <begin position="64"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH82215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="300" mass="31930" checksum="ED3C17F6B2315A03" modified="2015-07-22" version="1">MRKGAALVFTGAVAMSLVLAGCTGEGATQGKDKGSAAPSGGAEEAGAPSREARAAPRPPTSVAALGDSITRGFHACEPLTDCPEKSWSTGDSKDVESLARRLLDKPSGHTWNFARSGAQVADLPVQTGEAIARRPDLVTILMGANDACTESAEEMTPVADYRTAVADSLDRLEADLPRTQVYVSSVPSLMRLWEVGRGSVVTRQVWSLGICQSMLADPSDLGTTASGRREEVQDRVVAYNAVLAEECGKHPLCVYDDGAAFRYAFTGDHLSRWDSFHPDEDGQNALAEIAYEKLREAREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N139</accession>
    <name>A0A0F7N139_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Precorrin-2 C20-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AA958_05360</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015075.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_05360"/>
    <dbReference type="EnsemblBacteria" id="AKH81721">
        <property type="protein sequence ID" value="AKH81721"/>
        <property type="gene ID" value="AA958_05360"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_05360"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1124"/>
    <dbReference type="OrthoDB" id="1209876at2"/>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030788">
        <property type="term" value="F:precorrin-2 C20-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11645">
        <property type="entry name" value="Precorrin_2_C20_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012382">
        <property type="entry name" value="CobI/CbiL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006364">
        <property type="entry name" value="CobI/CbiL/CobIJ_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036427">
        <property type="entry name" value="Precrrn-2_mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="cobI_cbiL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="4 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="8">
        <location>
            <begin position="4"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR036427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH81721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="242" mass="24767" checksum="EE99C6B4861EAC39" modified="2015-07-22" version="1">MSMRLVGVGVGPGDPELVTVKGAGALRTAAVVVVPVMEGGGTGRAEATVLHYVDEAKVVRVVFALNERSDAARREAAWDAAGARVAELLRAHRSVAFATLGDPNVYSTFTYLAATVTALLPGVRIESVPGITAMQDLAARGGAVLAEGTEPLTLVPVTAGTAVLKEALRGPGTVVAYKFGRLAGEVAGALSETGRMEGAVWGSSLGLAEESVRPATELGAEPLPYLSTLIAPARRAGRGEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N1A2</accession>
    <name>A0A0F7N1A2_9ACTN</name>
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        <submittedName>
            <fullName evidence="4">Serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_02290</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH81193">
        <property type="protein sequence ID" value="AKH81193"/>
        <property type="gene ID" value="AA958_02290"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_02290"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.491"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519675" evidence="2">
        <location>
            <begin position="26"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="3">
        <location>
            <begin position="40"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH81193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="247" mass="24401" checksum="6BE8FA20E58A0F4D" modified="2015-07-22" version="1">MRTIMRLGGLTTAVVAILSMSGAAAATGGPEPTPPPTAQIVGGQPASETYSFMASLQSASGGHTCGGSLVDPSWVVTAAHCGTPYQVRIGTTDRTAGGEVRRVVERRQLAADMTLLRLGTPSTKTPVPIAASAPAGSATRLIGWGQTCPTRGCGAAPVGLRQLDTTVLADSSCAGIQGAYELCVNGGGGRGACYGDSGGPAVVGGPGDWRLVGATSRGTAGTCAVSPAIYGDVTSVKSRIDAIVGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N1A3</accession>
    <name>A0A0F7N1A3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_02120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014528.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_02120"/>
    <dbReference type="EnsemblBacteria" id="AKH81164">
        <property type="protein sequence ID" value="AKH81164"/>
        <property type="gene ID" value="AA958_02120"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_02120"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.456"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002731">
        <property type="entry name" value="ATPase_BadF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01869">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BcrAD_BadFG" evidence="2">
        <location>
            <begin position="74"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH81164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="330" mass="32541" checksum="11F0480F5E20CF68" modified="2015-07-22" version="1">MTSATPRWVLGIDSGGSGLRIAAAAVPADGGDPAEDDATVETAGPVATGDNGIDADDLLGKLLPAAHRLRGAAGAESFEAVCVGAAGMASLGADLRARLPHALADALGARHLALAADGVTAYAGAIGQHPGAVVAAGTGMIAVGTGLDAAGWRRADGWGHLLGDCGGGAWIGRAGLEAAMRAFDGRRGGSAALLARMETVFGTGTQMPGLLYPRPDRPAVLASFAPEVARCAPHDPVAAGILTEAGEHIAAAAVAVCPADPGSAVALTGGLFGIGEPLLAPLRAELAVRLPRARVSTATATPLAGSLRIAAALAAGELLLPVERGMLDVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N1H7</accession>
    <name>A0A0F7N1H7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LuxR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_02945</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014666.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_02945"/>
    <dbReference type="EnsemblBacteria" id="AKH81303">
        <property type="protein sequence ID" value="AKH81303"/>
        <property type="gene ID" value="AA958_02945"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_02945"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.629"/>
    <dbReference type="OrthoDB" id="930905at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="142"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH81303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="212" mass="22746" checksum="9D5C02A0A49339B0" modified="2015-07-22" version="1">MIVAEDSAILREGIVRLLGDAGVAVPAQCGDADPLLALVERHRPDAVLLDIRMPPTHTDEGLRAAAAIRARHPGTGVLLLSQYVETGTVVRALTEDPRGFGYLLKERVADADELAGALHRVAAGQSVVDPRVVTHLMRSPRAAEPLAGLTARERDVLALMAEGRSNEAIARDLVIGGKTVETHVRNIFAKLGLESEDSGHRRVLAVLRYLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N214</accession>
    <name>A0A0F7N214_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_00510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH80897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014263.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_00510"/>
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    </dbReference>
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    <dbReference type="PATRIC" id="fig|444103.5.peg.118"/>
    <dbReference type="OrthoDB" id="1984437at2"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
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    <dbReference type="InterPro" id="IPR041581">
        <property type="entry name" value="Glyoxalase_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18029">
        <property type="entry name" value="Glyoxalase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="4"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH80897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="128" mass="13897" checksum="FBF1AD73C48C7D74" modified="2015-07-22" version="1">MACRITELVIDTAAPERLAAFWSDVLGYVELGREDDGTIEIGPPDAGFGGLQPTLVLSASSEPRKGKLPLHIDVNATDRDQDAELERLLALGARHVDIGQTGEESWYPLADPEGNEFCLLRSRVRPVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-10-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N246</accession>
    <name>A0A0F7N246_9ACTN</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_07360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH82076">
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        <property type="gene ID" value="AA958_07360"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_07360"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1542"/>
    <dbReference type="OrthoDB" id="1956412at2"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Endoribo_LPSP/chorism_mut-like"/>
    </dbReference>
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        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="SSF55298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH82076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="125" mass="12536" checksum="A4107AD49D004BD2" modified="2015-07-22" version="1">MTPKDGTTLLATGRLGEQISLDEGRSLAAVAATRALTAATAAAEQAGTTLHSVVSMTVYVAVTADFTRISEVADGASATLVRAFGRASLPTRTAVGVATLPGGAPVEIQLIATIARNPHPDPPSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2F9</accession>
    <name>A0A0F7N2F9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Muramidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_08010</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 25 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_08010"/>
    <dbReference type="EnsemblBacteria" id="AKH82186">
        <property type="protein sequence ID" value="AKH82186"/>
        <property type="gene ID" value="AA958_08010"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_08010"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1689"/>
    <dbReference type="OrthoDB" id="1444566at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003796">
        <property type="term" value="F:lysozyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:cell wall macromolecule catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002053">
        <property type="entry name" value="Glyco_hydro_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018077">
        <property type="entry name" value="Glyco_hydro_fam25_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01183">
        <property type="entry name" value="Glyco_hydro_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00641">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51904">
        <property type="entry name" value="GLYCOSYL_HYDROL_F25_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="192"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH82186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="215" mass="23946" checksum="0269C5EE0E2ABEBC" modified="2015-07-22" version="1">MTIKGIDVSSHQSGNYSTRGMDFVFVKASEGRSYVNPKQGDQAAHGREAGLVLGFYHFLWPGNIKTQAQYFVDKAKEKPGDMLACDWEHTSEGTAASNKEKDAFIKEVKRLRPRHKVLLYCNRDFWLNRDTTSYAGDGLWIAQYNGKPGKPDIQASWRFHQYTSSPIDTNVGRFSSRSALRSWARERFDAKLTADGTEAGEPAGTAAGGGAEDRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2K5</accession>
    <name>A0A0F7N2K5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_00355</name>
        <name evidence="8" type="ORF">AA958_08325</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH80873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014239.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_00355"/>
    <dbReference type="EnsemblBacteria" id="AKH80873">
        <property type="protein sequence ID" value="AKH80873"/>
        <property type="gene ID" value="AA958_00355"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH82236">
        <property type="protein sequence ID" value="AKH82236"/>
        <property type="gene ID" value="AA958_08325"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_00355"/>
    <dbReference type="KEGG" id="strc:AA958_08325"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1756"/>
    <dbReference type="OrthoDB" id="1619224at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="183"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="290"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="95"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH80873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH82236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="318" mass="34808" checksum="E6B81F0D85294CEA" modified="2015-07-22" version="1">MPVTVKEPAAAAGPGPGGRKTGPQRRRRRGGLARLGPLPWIAPAIVLIVVVVLWPIYELIRTSFLNVSISGFVRGSAGTEKYRRLFDESGFSSVLTMTVVWTVAVVGVTMLLSLGLAQLFNKPFPGRTLTRWALIAPWAASVLMTAIGFRWMLDQTAGVLNTLMTDLGLIDGPKDWLGDPATAWPWMMFVAVFVSLPFTTYTLLAGLQTIPHEVYEAARIDGANSRQTYWRVTVPLLRPAFLVGFVINLINVFNSFPVIWAMTKGGPGSDTATTTVFMYQLKDTDIGESAAMSVVNFAMVVALVLIFLKVSRWNKEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2P5</accession>
    <name>A0A0F7N2P5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">3-hydroxybutyryl-CoA dehydrogenase</fullName>
            <ecNumber evidence="4">1.1.1.157</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_12230</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.1.157" evidence="4"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016210.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_12230"/>
    <dbReference type="EnsemblBacteria" id="AKH82875">
        <property type="protein sequence ID" value="AKH82875"/>
        <property type="gene ID" value="AA958_12230"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_12230"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2572"/>
    <dbReference type="OrthoDB" id="862072at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008691">
        <property type="term" value="F:3-hydroxybutyryl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022694">
        <property type="entry name" value="3-OHacyl-CoA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000105">
        <property type="entry name" value="HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3HCDH_N" evidence="3">
        <location>
            <begin position="19"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="3HCDH" evidence="2">
        <location>
            <begin position="203"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="1">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH82875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="299" mass="30347" checksum="58D69D2BF43C21ED" modified="2015-07-22" version="1">MTEHSTAPDGPGAQAPRAMAVVGGGRMGAGIAQSFATAGSRVVIVESGADAAAAAVARVAGSLRRAAERGRLAAGVDPDEVCARIRAVGSVAELPAEAGLELVVEAVPEDAGLKARVLAAAERAVGPDAVLATNTSSLSVAELAAALGRPARFLGMHFFNPVPASELVELVTAPETGAAALAAARGWTRTLGKTAVVVRDSPGFASSRLGVALGLEAIRMAEEGVAAPADIDTAMELGYKHPMGPLRLTDLVGLDVRLAIAEHLCGTLGERFAPPELLRAKVARGELGRKTGQGFYAWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2V5</accession>
    <name>A0A0F7N2V5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MerR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_12730</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016280.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_12730"/>
    <dbReference type="EnsemblBacteria" id="AKH82945">
        <property type="protein sequence ID" value="AKH82945"/>
        <property type="gene ID" value="AA958_12730"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_12730"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2675"/>
    <dbReference type="OrthoDB" id="1748559at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015358">
        <property type="entry name" value="Tscrpt_reg_MerR_DNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00376">
        <property type="entry name" value="MerR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09278">
        <property type="entry name" value="MerR-DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00552">
        <property type="entry name" value="HTH_MERR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH merR-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="91"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH82945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="136" mass="14667" checksum="CC599A393B5F80FF" modified="2015-07-22" version="1">MRIGELAERAGVSTRTLRYYESRGLLPAADRGANGHRVYGDDALRLVAQIRTLQDFGFELEDTRPFVECLRAGHPAGDSCPDARAVYRRKIAELDGLMAELRAARDHLTAQLARAEALPAPCGAAGTDGDVPLCCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2X5</accession>
    <name>A0A0F7N2X5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Assimilatory sulfite reductase (ferredoxin)</fullName>
            <ecNumber evidence="5">1.8.7.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">AA958_08955</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the reduction of sulfite to sulfide, a step in the biosynthesis of sulfur-containing amino acids and cofactors.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3 H2O + hydrogen sulfide + 6 oxidized [2Fe-2S]-[ferredoxin] = 7 H(+) + 6 reduced [2Fe-2S]-[ferredoxin] + sulfite</text>
            <dbReference type="Rhea" id="RHEA:23132"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="EC" id="1.8.7.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 12">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Nitrogen metabolism; nitrate reduction (assimilation).</text>
    </comment>
    <dbReference type="EC" id="1.8.7.1" evidence="5"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015683.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_08955"/>
    <dbReference type="EnsemblBacteria" id="AKH82336">
        <property type="protein sequence ID" value="AKH82336"/>
        <property type="gene ID" value="AA958_08955"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_08955"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1886"/>
    <dbReference type="OrthoDB" id="1128731at2"/>
    <dbReference type="UniPathway" id="UPA00653"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008942">
        <property type="term" value="F:nitrite reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050311">
        <property type="term" value="F:sulfite reductase (ferredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007419">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041854">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005117">
        <property type="entry name" value="NiRdtase/SiRdtase_haem-b_fer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036136">
        <property type="entry name" value="Nit/Sulf_reduc_fer-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012744">
        <property type="entry name" value="Nitri_red_NirB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017121">
        <property type="entry name" value="Nitrite_Rdtase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006067">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006066">
        <property type="entry name" value="NO2/SO3_Rdtase_FeS/sirohaem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041575">
        <property type="entry name" value="Rubredoxin_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04324">
        <property type="entry name" value="Fer2_BFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01077">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03460">
        <property type="entry name" value="NIR_SIR_ferr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18267">
        <property type="entry name" value="Rubredoxin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037149">
        <property type="entry name" value="NirB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00397">
        <property type="entry name" value="SIROHAEM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55124">
        <property type="entry name" value="SSF55124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56014">
        <property type="entry name" value="SSF56014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02374">
        <property type="entry name" value="nitri_red_nirB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00365">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 12" id="KW-0274">FAD</keyword>
    <keyword evidence="7 12" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 12" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0883">Thioether bond</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="16">
        <location>
            <begin position="10"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="Rubredoxin_C" evidence="17">
        <location>
            <begin position="331"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="Fer2_BFD" evidence="15">
        <location>
            <begin position="430"/>
            <end position="478"/>
        </location>
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        <location>
            <begin position="578"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="domain" description="NIR_SIR" evidence="13">
        <location>
            <begin position="650"/>
            <end position="775"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR037149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF03460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF18267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="AKH82336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="871" mass="91492" checksum="F9490D71E0506BC1" modified="2015-07-22" version="1">MTAAPHSRTLVLVGHGMVGQRFLEALAEHRVTDTHRVVVFCEEPRPAYDRMHLTSYFSGTTPEGLSVTPDGFMAEHGIELHVGDPAVAVDRAARTVTSAAGRTVPYDVLVLATGSFPFVPPVPGKDARGCFVYRTVEDVLAIEAYAQGASAGVVVGGGLLGLEAAGALRGLGLATHIVEFAPRLMPVQVDEGGGAALRRTIGDLGLDVHTGVAGKEIRTDAAGAVTGMELSDGSVVAADLVVFSAGVRPRDRLAREAGLDVGERGGVAVDERCRTSDPAVFAIGECAQAADGRVYGLVAPGYEMAETAAAAIATAQAPAAAPKTFTGADTSTKLKLLGVGVASFGDALGTADDCLDVVYSDSRAGLYKKLVVARDGTLLGGVLVGDTDAYGMLRPLTGSVPPVPPEQLVLPPGAGAPAALGPAALPDDAVVCNCHNVTKAAIRGAVAEHDCTTVREVEKCTRAGSGCGSCEKVLTALVNDELAARGVAVDKGLCRCFAHTRTELYEIVRVKRISSYVRLLDEHGREEARSGDGCEVCKPAVASIFASLAPEIGAAGYVLDGEQGALQDTNDHFLANLQRNGSYSVVPRVPGGEITPGKLIVLGEVARDFGLYTKITGGQRIDLFGARVDQLPAIWARLVEAGFESGHAYGKALRTVKSCVGSTWCRYGVQDSVRMAIDLELRYRGLRSPHKLKAAVSGCSRECAEAQGKDFGVIATANGWNLYVCGNGGATPRHADLLAQDLADDELIRLIDRFLMFYIRTADRLERTSVWLERLEGGLGHLRDVVVADSLGIGAELEEQMAAHVAHYRDEWAATLADPERLARFVSFVNAPGVPDPTVRFVPERDQVKPDLTLLSGPAIPVRGTLEGASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2Y7</accession>
    <name>A0A0F7N2Y7_9ACTN</name>
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        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_09050</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AKH82351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AKH82351">
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        <property type="gene ID" value="AA958_09050"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_09050"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1907"/>
    <dbReference type="Proteomes" id="UP000034283">
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    </dbReference>
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        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="PL-6"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Alginate_lyase_2"/>
    </dbReference>
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        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="GH16"/>
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    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
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        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
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        <property type="entry name" value="PL-6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08787">
        <property type="entry name" value="Alginate_lyase2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14592">
        <property type="entry name" value="Chondroitinas_B"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="F5_F8_type_C"/>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
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            <begin position="391"/>
            <end position="623"/>
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            <begin position="223"/>
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    </feature>
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            <begin position="1186"/>
            <end position="1217"/>
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    </feature>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="1217" mass="130751" checksum="89B2975E6CFAB9D4" modified="2015-07-22" version="1">MGLLALGVSAAYHPVASAEAGPRLAVAGVLASADDGNVAANTLDNDLSTRWSAEGEGVWIRYDLGSAKTVGSASIAWHQGDTRKNTFDVEVSDDGSSWTPVLSRKTSSGTTLQPQNYDFADTTARYLRIVGHGNTSNDWTSITETALYGADGGGDSCDYPADVLDLTDWYIGLPVGEEESPTNVYQPELATYANDPWFTATPDCDAVQFRAAVNGVTTSGSNYPRSELREMTDSGETKASWSSTSGTHTMVIDQAITDLPADKPHVVAGQIHDADDDVSVFRLEGSKLYVTSPDDSNYKLVTDDYALGDRFQAKFVVGDGEIKAYYNGVLQTTLAADFEGGYFKAGAYTQADCERSSPCSDDNYGQVEIYDLSVTHDDGQGAGDPTEAAERYGWGEPLPISDEFDYTGPVDPEKWDVPSGTVGGTAQCWEGHAGNGRRCGKNSTVADGIMTMRGEANGDTGWIRQSRDTQYARWEIRSRSRNTGSSGGLYHPLHLIWPTAGDRLKNGEYDWVEYSNPDAQCLSAFLHYPESPSDEKEYRELCPVDMTQWHNFAFEWTPDALVGYVDGAEWFRLADGANSDRGDIQKMPLGNLVIQLDNFTGDSGLRPAVFEVDWVRTYPVTPGGDSPGAPVPVTGVTASAHDGNVAANTLDNDLSTRWSAEGEGVWIRYDLGSAKTAGSASIAWHQGDTRKNTFDVEVSDDGSSWRTVLSRQTSSGTTLQPQKYDFADTTARYLRIVGHGNTSNDWTSITETAIYGADGGDGGDPGDPGPGRTVEVADSDQLRDAMGDARAGDRIVLADGEYTIGKMSGRNGTADEPITVVAENRGRAVVTDGQLEVAGSSYVTFEGLKWTNSDTLKITGSNNVRLTRNHFRLTEESSLKWVIIQGANSHHNRIDHNLFEEKHQLGNFITIDGSETQQSQHDRIDHNHFRNIGPRAANEMEAIRVGWSEISQSSGFTVVESNLFEDCDGDPEIVSVKSNDNIVRHNTFRTSQGVLSQRHGNRGAFYGNFFLGEGKAGTGGIRLYGQDHKIYNNYFEGLTGTGHDAALQIDGGDVDTSGALNAHWRVYRATVVNNTFVDNVSNIEVGANYRLAPVDSVVADNVVTGGTGKLFNELKAPVDMTYAGNIAWPTGSATIGVTVPSDAVRAADPLLAPDGPVHRIGAGSPAIDAGTGRFAFVTDDMDGQARTGAVDAGADERSSSAVTRAPLTAADVGPSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N340</accession>
    <name>A0A0F7N340_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_09450</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015760.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_09450"/>
    <dbReference type="EnsemblBacteria" id="AKH82416">
        <property type="protein sequence ID" value="AKH82416"/>
        <property type="gene ID" value="AA958_09450"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_09450"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1994"/>
    <dbReference type="OrthoDB" id="1108236at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="237"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="303"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="339"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="369"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="400"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="436"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="472"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="38"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH82416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="497" mass="50414" checksum="15A4102DA787B278" modified="2015-07-22" version="1">MPDTTTTSPGGGSAPGAAAVSSKARGTDNAAGTRTGWLLGIVLAGQFMALLDVFIVNVAAPTMRTDLGTSGAELQLIIAGYVISYSVLLITGARLGAMLGHRRMYLGGLVLFTAASLACGLAATSGQLIAFRLVQGAGAAAMIPQVLSLIQRNFTGTERVRALGVYAAVLATGAAAGQIAGGLLVSADLFGWSWRPVFLVNVVVGVPLLVLGARLLPPDEPRSAAGGTPYGGVLDRGGLVLLAAAVTLFTVPLVLGQELDWPVWGWVMLGGSVAAAVAFAAYESGLARRGGVPLFPPRVVRAPGMPVAVVRSGLAMVLNGAFMFVMALHLQSGLGFGPLRAGLTFVPTAVAFGAAGLTWQRLPERLHPALVPAGFVTLTVSFLAVGLAMRGAGEGGPGFYAGLTGVGLGLALAFSPNLTAALALVRTEDAPHASGLLTTTAQLGGLIGVATIGTLYLERVGALTARSSADAVWYALLALAAVGVLGLLAGVRYRYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3B1</accession>
    <name>A0A0F7N3B1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative_PNPOx domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_10085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015858.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_10085"/>
    <dbReference type="EnsemblBacteria" id="AKH82516">
        <property type="protein sequence ID" value="AKH82516"/>
        <property type="gene ID" value="AA958_10085"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_10085"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2124"/>
    <dbReference type="OrthoDB" id="1804797at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="1">
        <location>
            <begin position="11"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="161" mass="17168" checksum="89317341F734E4BF" modified="2015-07-22" version="1">MTLPDDLAGLARSVLDANRYLTLGTAEPDGRPRVSPVFFTHAGYRTFYWVSSPRARHSANVAARPAVEFVVYDSTAAIGEGRAVYVGATAEEVPEAQLAAACDEAFGGAVAAGATRFRPPDLSGDAGLRLYRARATSCEVHVPGRDPVYGTGIDTRREVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3G6</accession>
    <name>A0A0F7N3G6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_10525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015928.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_10525"/>
    <dbReference type="EnsemblBacteria" id="AKH82586">
        <property type="protein sequence ID" value="AKH82586"/>
        <property type="gene ID" value="AA958_10525"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_10525"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2217"/>
    <dbReference type="OrthoDB" id="1899562at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="126" mass="13806" checksum="766674B86C1C2BC7" modified="2015-07-22" version="1">MTEPDPARPGRTEQPRTPRRPAALLFEPPLAEPDAEHFFGLESIEDPGELLARATDLTLAFRAATDRAIEYQAMAAAQLADPKRFDRLTPEAIAERADWTEDYAKRMVEYGRDLLAGGGPGSPAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3W5</accession>
    <name>A0A0F7N3W5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SseB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_04355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014902.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_04355"/>
    <dbReference type="EnsemblBacteria" id="AKH81547">
        <property type="protein sequence ID" value="AKH81547"/>
        <property type="gene ID" value="AA958_04355"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_04355"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.915"/>
    <dbReference type="OrthoDB" id="2025194at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009839">
        <property type="entry name" value="SseB_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07179">
        <property type="entry name" value="SseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SseB" evidence="1">
        <location>
            <begin position="14"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="131" mass="13999" checksum="3712B8749820ACD7" modified="2015-07-22" version="1">MTYHPNGQRSAAQQALHTVAENGPDQEALHTLAESRVLLPDPEPAEEPPGQAQALSLPVVEQGDGTRLVPVFTSPDRLEQVFPEIERYNAVELGDLARGWPADGPSLVVDAGTPEEMALTAEGVRELLGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N445</accession>
    <name>A0A0F7N445_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Serine--tRNA ligase</fullName>
            <ecNumber evidence="7">6.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Seryl-tRNA synthetase</fullName>
            <shortName evidence="7">SerRS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Seryl-tRNA(Ser/Sec) synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">serS</name>
        <name evidence="10" type="ORF">AA958_15725</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + L-serine + tRNA(Sec) = AMP + diphosphate + H(+) + L-seryl-tRNA(Sec)</text>
            <dbReference type="Rhea" id="RHEA:42580"/>
            <dbReference type="Rhea" id="RHEA-COMP:9742"/>
            <dbReference type="Rhea" id="RHEA-COMP:10128"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78533"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + L-serine + tRNA(Ser) = AMP + diphosphate + H(+) + L-seryl-tRNA(Ser)</text>
            <dbReference type="Rhea" id="RHEA:12292"/>
            <dbReference type="Rhea" id="RHEA-COMP:9669"/>
            <dbReference type="Rhea" id="RHEA-COMP:9703"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78533"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Aminoacyl-tRNA biosynthesis; selenocysteinyl-tRNA(Sec) biosynthesis; L-seryl-tRNA(Sec) from L-serine and tRNA(Sec): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer. The tRNA molecule binds across the dimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.11" evidence="7"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_15725"/>
    <dbReference type="EnsemblBacteria" id="AKH83415">
        <property type="protein sequence ID" value="AKH83415"/>
        <property type="gene ID" value="AA958_15725"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_15725"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3314"/>
    <dbReference type="UniPathway" id="UPA00906">
        <property type="reaction ID" value="UER00895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004828">
        <property type="term" value="F:serine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016260">
        <property type="term" value="P:selenocysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097056">
        <property type="term" value="P:selenocysteinyl-tRNA(Sec) biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006434">
        <property type="term" value="P:seryl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00770">
        <property type="entry name" value="SerRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00176">
        <property type="entry name" value="Ser_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002317">
        <property type="entry name" value="Ser-tRNA-ligase_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015866">
        <property type="entry name" value="Ser-tRNA-synth_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042103">
        <property type="entry name" value="SerRS_1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033729">
        <property type="entry name" value="SerRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11778">
        <property type="entry name" value="PTHR11778"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02403">
        <property type="entry name" value="Seryl_tRNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001529">
        <property type="entry name" value="Ser-tRNA-synth_IIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00981">
        <property type="entry name" value="TRNASYNTHSER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="SSF46589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00414">
        <property type="entry name" value="serS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
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    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="9">
        <location>
            <begin position="126"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Serine binding" evidence="7">
        <location>
            <begin position="217"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="248"/>
            <end position="250"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="335"/>
            <end position="338"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="373"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="HAMAP-Rule" id="MF_00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AKH83415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="416" mass="45511" checksum="5F87700B5BDAD02B" modified="2015-07-22" version="1">MRASQRARGEDVALVDALLSADERRRSSSTRFDELRAEQKQLGKLIPRAQGEEKQELLRRTGELSAAVKAADAAQDEAAAETQALLLRLANVVHPDVPVGGEDDFALLETVGTPRDFAAEGFEPRDHLELGRILGAIDTERAAKVSGSRFYYLTGVGALLELALVNAAIAQATAAGFTPMLTPALVKPRAMEGTGFLGQAAEDVYYLERDDFYLVGTSEVTLAAYHMDEIIEADRLPLRYAGFSPCFRREAGSHGKDTRGIIRVHQFDKVEMFSYVAPEDAEAEHARLLDWEKQWLSALGLAYRVIDVASGDLGASAARKYDCEAWIPTQGKYRELTSTSNCGEFQARRLSVRMRDGQGQKKAARPLATLNGTLCAVPRTIVAILETHQQPDGSVVVPEVLRPYLGGRELLEPVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N489</accession>
    <name>A0A0F7N489_9ACTN</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
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        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519766" evidence="1">
        <location>
            <begin position="28"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83460.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="178" mass="18155" checksum="F3293064870EF50F" modified="2015-07-22" version="1">MRVRSALTALALVAGASVGLAAAPAQAAPAAPTVAAAPAAPLVTKISHSQATSMFRSSGITWSSSGGCSDRNNPTCTSFEQLNLASAQGAQTLKSASGCALNITGGTETGHAGGTYSHWNGYKLDYSLSTCVNNYVTGNFAYIGVRGDGAPMYRSGSGNIYAREGNHWDVTYYNCGGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
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                <person name="Winkler A."/>
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                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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            <begin position="20"/>
            <end position="293"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="295" mass="30929" checksum="751BE0DDC2152760" modified="2015-07-22" version="1">MTAETAAGTFRIGGDLEVGRLGFGAMQLPAGPADARAASVAVARRAVELGVTLIDTAHLYGGGANEELLAEALYPYPEELLITTKVGVARSAETGEWGLDGRPEVLREQVDHALRRLRVERIELLQLHRIDPEVDLAEQVGALRELQEAGKVARLGLSEVTAGELARARELVDVASVQNRYSVGDREHEAVLDACAAAGIAFLPWRPVLGAVPPADAAGAPDAGGPQAPYRVIGAVARELGATPVQVALAWLLAHSPVVLPIPGTAKLGHLEENVAAAGVRLEPAHLERLDALSS</sequence>
</entry>
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    <accession>A0A0F7N4N1</accession>
    <name>A0A0F7N4N1_9ACTN</name>
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        <submittedName>
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        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">AA958_12790</name>
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    <organism evidence="1 2">
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        </lineage>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <dbReference type="PATRIC" id="fig|444103.5.peg.2687"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ADP_ribosyl_GH"/>
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    </dbReference>
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH82956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="369" mass="39102" checksum="002DADD99114F529" modified="2015-07-22" version="1">MTTARRTWGRAEQQDFRSRVRGCLLGGAIGDALGAGIAAASLAEIRAEHGPQGAVDFAPAYGRRGAVTDDTQMTLFTVDGLIRAQVRRDGGRWHPPTDVHTAYRRWYATQKDWGPDERKAEDGWLAREEWLYSQRGAPRASLRGLADDRMGTLQQPRNPEAKDPGAVVRSAPFGLLVGWEPQLVFQLAAECATQTHGHATGYLAAGAYAVVVHGLARGDVPEEAVARALEILAGRPGHEETAAALRTALDARQGPEPGPEQVEGLGTGESAAEAVALALYCALAATDVRHGLLLAVNHGGASDATGSLCGSLLGAQHGETALPPAWVAEVEGRGTILQLADDFALEMTLGPALHGESAPNDAWLLRYPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4N4</accession>
    <name>A0A0F7N4N4_9ACTN</name>
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        <recommendedName>
            <fullName evidence="2">NAD_binding_9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">AA958_08920</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_08920"/>
    <dbReference type="EnsemblBacteria" id="AKH82329">
        <property type="protein sequence ID" value="AKH82329"/>
        <property type="gene ID" value="AA958_08920"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_08920"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1878"/>
    <dbReference type="OrthoDB" id="1239213at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038732">
        <property type="entry name" value="HpyO_NAD-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13454">
        <property type="entry name" value="NAD_binding_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_binding_9" evidence="2">
        <location>
            <begin position="10"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="566"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="575"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH82329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="590" mass="62132" checksum="E87B3A4799FF6F5C" modified="2015-07-22" version="1">MSEKSLVVGVVGAGPRGLSVVERLAAHAAGRAVTVHLIDPLPPGAGREWRTGQDRSLLLDRTAGRVTAFAGEGVMPADAPQRRGPGLYEWARALARSGAGGADAAEARRLGPDSYPTRALAGSYFRWVFRQVAVASAESLALRVHAAQAVALDDGPGGTQEIRLTGGRRLTGLDAVVLAQGRMPVLPTARERGYAAFAAEFGLVYVAPGNPADADLSAIAPGEPVVLRGLGLNFFDYLTLLTTGRGGRFDRDRDGRVTYRPSGREPRVLCGARRAVPYGTGGGHRNGGGRRLPRVFTEELTARLRAQHDGPLDFRESLWPLIAREMESAYYTALLPGRDRPERAPVLHGVRPGAGPRGGAAGGPVEAALDVLHDLRDEVRLAVDHAGLGGESRRRDLDGWFAPLGTYLSGGPAARRTEELIALVRAGVARIVGPGMQVAADREAGTFACESPWVSGSRETARVLVEGRLPGVDLRRTADPLLRHLLDTGQCRPYGLGPGRTGYVAGGLAVTGRPFHVVDGDGAPHPRRFAVGVPTESADGVTAAAIRPAVGSATLTDTDAIARAVLAPAGPPPRGRDDRSNRRAEEARRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4T7</accession>
    <name>A0A0F7N4T7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2-isopropylmalate synthase</fullName>
            <ecNumber evidence="3">2.3.3.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Alpha-IPM synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Alpha-isopropylmalate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">leuA</name>
        <name evidence="6" type="ORF">AA958_09250</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>3-methyl-2-oxobutanoate + acetyl-CoA + H2O = (2S)-2-isopropylmalate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21524"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.13" evidence="3"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015730.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_09250"/>
    <dbReference type="EnsemblBacteria" id="AKH82384">
        <property type="protein sequence ID" value="AKH82384"/>
        <property type="gene ID" value="AA958_09250"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_09250"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1952"/>
    <dbReference type="OrthoDB" id="840579at2"/>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003852">
        <property type="term" value="F:2-isopropylmalate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07942">
        <property type="entry name" value="DRE_TIM_LeuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00572">
        <property type="entry name" value="LeuA_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013709">
        <property type="entry name" value="2-isopropylmalate_synth_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002034">
        <property type="entry name" value="AIPM/Hcit_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005668">
        <property type="entry name" value="IPM_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036230">
        <property type="entry name" value="LeuA_allosteric_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039371">
        <property type="entry name" value="LeuA_N_DRE-TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08502">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00917">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110921">
        <property type="entry name" value="SSF110921"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00970">
        <property type="entry name" value="leuA_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00815">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00816">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 3" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="5">
        <location>
            <begin position="53"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH82384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="588" mass="64861" checksum="A1D0EFD4F84A7C2D" modified="2015-07-22" version="1">MDHPGNTAGRGTPVTAATVRQQPSGMPVHRYRPYDAVDIPDRTWPGNRITQAPRWLSTDLRDGNQALIDPMSPARKRAMFDLLVRMGYKEIEVGFPSSGQTDFDFVRSIIEDGAIPEDVTISVLTQAREELIERTVASLKGARRATVHLYNATAPVWREVVFRGSRDAVKQIAVDGTRLVVEYAEKLLDDRTTFGYQYSPEIFTDTELDFALEVCEGVMDVWQPEDGREIILNLPATVERSTPSTHADRFEWMSRNLSRREHVCLSVHPHNDRGTAVAAAELALMAGADRVEGCLFGQGERTGNVDLVTLGMNLFSQGVDPMIDFSEIDEIRRTYEYCNQMGVHPRHPYVGDLVYTAFSGSHQDAIKKGFEAMEARAAQAGKPVEELEWAVPYLPIDPKDVGRSYEAVIRVNSQSGKGGVAYVLQHDHSLDLPRRMQVEFSRIIQTKTDAEGGEVTPAQIWDVFRDEYLPNPGNAWGRIQLRGGQTTTDRDGVDTLTVQADVDGAETTLVGTGNGPISAFFHALQGIGIDARLLDYQEHTMSEGASAQAASYIEVAVDGKVLWGIGIDANTTRASLKAVVSAVNRAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4V0</accession>
    <name>A0A0F7N4V0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_13215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016363.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_13215"/>
    <dbReference type="EnsemblBacteria" id="AKH83031">
        <property type="protein sequence ID" value="AKH83031"/>
        <property type="gene ID" value="AA958_13215"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_13215"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2781"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019681">
        <property type="entry name" value="DUF2530"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10745">
        <property type="entry name" value="DUF2530"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="88" mass="9738" checksum="2127236DCFBD42CB" modified="2015-07-22" version="1">MGKKAYRHPAPEPFEGDITAVTVGGTVLWLVLFVVQLPFLGWLDDHDRMWWLWTCLAGAGLGVLGLWYVRRREAALARGGDAGARSNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4X4</accession>
    <name>A0A0F7N4X4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribose 5-phosphate isomerase</fullName>
            <ecNumber evidence="4">5.3.1.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_09710</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LacAB/RpiB family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.6" evidence="4"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015801.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_09710"/>
    <dbReference type="EnsemblBacteria" id="AKH82458">
        <property type="protein sequence ID" value="AKH82458"/>
        <property type="gene ID" value="AA958_09710"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_09710"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2043"/>
    <dbReference type="OrthoDB" id="1346802at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004751">
        <property type="term" value="F:ribose-5-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011860">
        <property type="entry name" value="Rib-5-P_Isoase_Actino"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003500">
        <property type="entry name" value="RpiB_LacA_LacB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036569">
        <property type="entry name" value="RpiB_LacA_LacB_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30345">
        <property type="entry name" value="PTHR30345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02502">
        <property type="entry name" value="LacAB_rpiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005384">
        <property type="entry name" value="RpiB_LacA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89623">
        <property type="entry name" value="SSF89623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02133">
        <property type="entry name" value="RPI_actino"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00689">
        <property type="entry name" value="rpiB_lacA_lacB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="D-ribulose 5-phosphate binding" evidence="3">
        <location>
            <begin position="8"/>
            <end position="9"/>
        </location>
    </feature>
    <feature type="region of interest" description="D-ribulose 5-phosphate binding" evidence="3">
        <location>
            <begin position="67"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR005384-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH82458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="161" mass="17584" checksum="7B4AC726A5168F9A" modified="2015-07-22" version="1">MRVYLGSDHAGYELKEHLLAWLREHGHEPVDCGPLIYDAADDYPPFCLRAAERTAADPGSLGVVIGGSGNGEQIAANKVAGVRSALAWSEETARLAREHNDANVVSVGARMHTRDEATSFVEVFLATPYSGEERHQRRIDMLSAYEQSGKLPDVPAHHPQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N536</accession>
    <name>A0A0F7N536_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_13750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016450.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH83121">
        <property type="protein sequence ID" value="AKH83121"/>
        <property type="gene ID" value="AA958_13750"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_13750"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2895"/>
    <dbReference type="OrthoDB" id="1270792at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013653">
        <property type="entry name" value="FR47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08445">
        <property type="entry name" value="FR47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="148"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="287" mass="30444" checksum="342D874FC1DA2989" modified="2015-07-22" version="1">MRADGWHLTEDLDEFLAEAGEFLRDRPVPHIMALTWAARLKARGTGPYGGGRLLLGRLSRAGSVAGACHQLPGRSLGLTPLTPAETDSLAAHLAALGHTPPGVGGDHDTTTAFAAAWQRHTGATPTPAVRLRLRRLRTLTPPDPAPAGRARAAGEADHEQLMDFCRGFAADVREDVTIDAATWPTTRYADKHYTFWETPDGTPVSTAGVNPAVAGLAQVDPVYTPSAHRGHGYAAAVTAAVTRAALTAGAREVALFTDATNPTSNALYQRLGYDVFADWTTYTFAQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5A5</accession>
    <name>A0A0F7N5A5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_10565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015934.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_10565"/>
    <dbReference type="EnsemblBacteria" id="AKH82593">
        <property type="protein sequence ID" value="AKH82593"/>
        <property type="gene ID" value="AA958_10565"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_10565"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2224"/>
    <dbReference type="OrthoDB" id="1239251at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="PTHR11895"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="SSF75304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="1">
        <location>
            <begin position="28"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="481" mass="50500" checksum="CA0520853C1B7FC0" modified="2015-07-22" version="1">MTGSTDPADLTAVELLRRYRSGELSPVEATRAALARAARAQELTNAFVTLDDAVRDAALARAEASARRWQRGEPAGLLDGVPVTVKDMILERGAPTLRGSRLVDPDREWNEDGPSVARLREHGAVFLGKTTTPEFGWKGTTDSPLNGVTVNPYDAGRTTGGSSGGSAAAVALGAGPLSLGTDGGGSVRIPAAFCGIVALKATYGRVPLYPASPFGTLAHVGPMTRDVRDTALMMDVISGADPRDWSQLGPPAGGFVDALDGAAEGVRGLRVAYSPTFGGQVPVDRQVAAVVRGAVERLSDLGAYVEEADPRLCEGLAACQEAFHTLWFSGAARVVQPYGPGARELLDPGLREIVELGERYSALDYLAAVDVRMALGQSMGRFHQTYDVLVTPTVPITAFEAGAEVPKDSGFTRWTGWTPFTYPFNLTQQPAVSLPCGVDGAGLPVGLQLVAARHRDALVLRTAQALYESGIADGIRPPALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5C9</accession>
    <name>A0A0F7N5C9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_14375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016537.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_14375"/>
    <dbReference type="EnsemblBacteria" id="AKH83221">
        <property type="protein sequence ID" value="AKH83221"/>
        <property type="gene ID" value="AA958_14375"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_14375"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3025"/>
    <dbReference type="OrthoDB" id="1374721at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003812">
        <property type="entry name" value="Fido"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036597">
        <property type="entry name" value="Fido-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02661">
        <property type="entry name" value="Fic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140931">
        <property type="entry name" value="SSF140931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51459">
        <property type="entry name" value="FIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fido" evidence="1">
        <location>
            <begin position="104"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="281" mass="28496" checksum="E0988E187163D6FF" modified="2015-07-22" version="1">MTSVTDPLAALSTLPGVEEAVSSVRRAVDRVYGHRVMRRRSNEVSAEAALRGARASAALSGADWALEEVRRRSDFSGAGEPRTVGGALRANAEAGQLLSTWRQSPMQVLARLHVVASAGTGDSTAGDAGEAVGRPRLTGEGVTEAGAVLPSPLPDAEEAAARLDALAALVVAGSSAPALVMAAVVHGELLTLRPFRTGNGLVARAAERIVLVGSGLDPKGVCPAEVGHAEQGRGAYETALAGYASGTPEGVGGWIAHCGRAVELGARESTAVCEALQRGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5J8</accession>
    <name>A0A0F7N5J8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF2382 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_07450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015442.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH82092">
        <property type="protein sequence ID" value="AKH82092"/>
        <property type="gene ID" value="AA958_07450"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_07450"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1561"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019060">
        <property type="entry name" value="DUF2382"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09557">
        <property type="entry name" value="DUF2382"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2382" evidence="2">
        <location>
            <begin position="63"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH82092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="242" mass="26249" checksum="2096C0011DA5D1B6" modified="2015-07-22" version="1">MQTDRNTASGGSGKAAEAAGVGRETDAAAAAGGGGQGEQSRRGQQPENAQRGGAAEDQRVVAYRERLQVEPVDRRQPMGEAEVTIRVRETPQRFEVTRGHDECVVRRSDVDGKEGNLIAGDHHEFVERSVKVPLYGEDAEVIVHKVSEPYAVADIGTRRIEDTQTFETVLKTEEIVENVPAGSNASMRVREVQEGYDLREGARRQQQEQSSGTSGHAAAPETADTPGAAEDIGKGKGRRRWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5P0</accession>
    <name>A0A0F7N5P0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoribosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_11290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016055.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_11290"/>
    <dbReference type="EnsemblBacteria" id="AKH82718">
        <property type="protein sequence ID" value="AKH82718"/>
        <property type="gene ID" value="AA958_11290"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_11290"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2379"/>
    <dbReference type="OrthoDB" id="1937725at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="1">
        <location>
            <begin position="145"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="199" mass="20614" checksum="0ADFA3FE97DB29A7" modified="2015-07-22" version="1">MRRVVPRPRPRGLPAVYAAVAYAGAARSALLAHKERGALRLARPLGTALAAGVRVCGHGGERVVLVPVPSARGAVVRRGHDPVRRLALVAAERLRRGGIRAELLPVLRQRRAVADQAGLSAVARQRNVSGALEVVRCGALRLRAPGCRVVLVDDVLTTGASLAEAARAVRAAGCRGGLAAAVVAAPRDAFEAGRACPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5V3</accession>
    <name>A0A0F7N5V3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_08095</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015547.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_08095"/>
    <dbReference type="EnsemblBacteria" id="AKH82197">
        <property type="protein sequence ID" value="AKH82197"/>
        <property type="gene ID" value="AA958_08095"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_08095"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1706"/>
    <dbReference type="OrthoDB" id="1948290at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002935">
        <property type="entry name" value="SAM_O-MeTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01596">
        <property type="entry name" value="Methyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51682">
        <property type="entry name" value="SAM_OMT_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH82197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="225" mass="24558" checksum="7F96D0E124A08328" modified="2015-07-22" version="1">MTSPSPADRDKRPDQTPELYRYVLEHNPPLDAVQRDLVELTHSRFPDSASMQSAQEQGPLLAFLVRLVGARHIVEVGTFTGFSSLSMAQALPADGKLVALDVSEEWTAYAREAWEKGGVADRVELRIGPAADSLRAMPAEPHIDLAYLDADKGGYVGYWEELVPRMRPGGLIVADNVLFHGRVVDPDATGGAAAIRTFNDHVVADDRMDSVLLTVADGLTVARRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6C0</accession>
    <name>A0A0F7N6C0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_12775</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_027770634.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_12775"/>
    <dbReference type="EnsemblBacteria" id="AKH82953">
        <property type="protein sequence ID" value="AKH82953"/>
        <property type="gene ID" value="AA958_12775"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_12775"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2684"/>
    <dbReference type="OrthoDB" id="1857091at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043231">
        <property type="term" value="C:intracellular membrane-bounded organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070273">
        <property type="term" value="F:phosphatidylinositol-4-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008628">
        <property type="entry name" value="GPP34-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038261">
        <property type="entry name" value="GPP34-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12704">
        <property type="entry name" value="PTHR12704"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05719">
        <property type="entry name" value="GPP34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="208"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH82953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="249" mass="26283" checksum="72845F23921A8F9C" modified="2015-07-22" version="1">MGRSRRTLPEELLLLALDPATGTTAQPQSLDLGLAGAQLVELALAGRIAPDGDRIAVILPRPTGDPTLDTALELLRRRGSPVRAVNWIGGPRLGLRQTYLAHLERCGMVHAVESQMCGVLPTTRYQATDTAISREIRARLDSAIRTGVPPDPRTAALAALAHAVGLGKHLYPGNEGRSARSRLRDLIRHDPMGGLVAHAVMDVQNGVTAQPRRTPGGGRPAARPPAVAQPAGVPAGSRRAGMIRTAAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6E7</accession>
    <name>A0A0F7N6E7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Geranylgeranyl pyrophosphate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_20655</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017486.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_20655"/>
    <dbReference type="EnsemblBacteria" id="AKH84200">
        <property type="protein sequence ID" value="AKH84200"/>
        <property type="gene ID" value="AA958_20655"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_20655"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4357"/>
    <dbReference type="OrthoDB" id="1861068at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH84200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="336" mass="35501" checksum="57D64A3B3E8CB5E9" modified="2015-07-22" version="1">MTVVAPLGLSVQDRALEADVEAGLAAVEEGLLEATKSDVPFITEAARHLVRAGGKRFRPLLVMLAAQFGDPHAPGVAPSGVVVELTHLATLYHDDVMDEAAVRRGVPSANSRWANSVAVLTGDFLFARASRLLADLGPEMVRIQAQAFERLVTGQILETAGPTEGRDPVDHYLDVLAGKTGSLIAVSGRFGALTAGADESVVEVLTQYGERIGIAFQLADDLLDITSDGTESGKTPGTDLREGVATLPVLHLRAAAQRHRKPADLELAALLADDLTDDSRHAEALARLRVHPAVEQARRDTVRYAAEARAILTALPACPARTALEGLCDAVVDRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6Y0</accession>
    <name>A0A0F7N6Y0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_13875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016471.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_13875"/>
    <dbReference type="EnsemblBacteria" id="AKH83143">
        <property type="protein sequence ID" value="AKH83143"/>
        <property type="gene ID" value="AA958_13875"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_13875"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2921"/>
    <dbReference type="OrthoDB" id="1865374at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="279" mass="29378" checksum="1CAD5E3AE952A781" modified="2015-07-22" version="1">MTSPPPRHSPDPAPPGPAASRPGARRPLPHPAAPPPRLDVTDDAWDRADPYARALRSGAGPLFLRRHDGWLLPLDVERWCGVPDGGDVTVLRRCTGPVLDIGCGPGRLVAALAALGRPALGVDVSSEAVAHARSRGAAALRRSVFEPLPGEGRWGTALLVDGNVGIGGDPAALLARAAALLRPRGRLVVEVAADDDVDERVHVHVTDGTFGTHGAGGTPHSAAGPRPERAAFPWARVGLPALLRYAAAGRWREEDRWTAGGRRFAALRAPEPTPRTARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N752</accession>
    <name>A0A0F7N752_9ACTN</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_18680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017188.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_18680"/>
    <dbReference type="EnsemblBacteria" id="AKH83891">
        <property type="protein sequence ID" value="AKH83891"/>
        <property type="gene ID" value="AA958_18680"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_18680"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3917"/>
    <dbReference type="OrthoDB" id="1867074at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010428">
        <property type="entry name" value="Zincin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038555">
        <property type="entry name" value="Zincin_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06262">
        <property type="entry name" value="Zincin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH83891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="119" mass="13361" checksum="BFF9ACB3697790E7" modified="2015-07-22" version="1">MGRVLDMSNEEFEELVAQALDRIPAELTRLMDNVAVFVEPEPPPDDPGLLGLYEGTPLTERGEWYAGVLPDRITIYRGPTLRMCESREDVVAETEITVVHEIAHHFGIDDDRLHALGYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7B0</accession>
    <name>A0A0F7N7B0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Phosphomannomutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">manB</name>
        <name evidence="9" type="ORF">AA958_11360</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016064.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_11360"/>
    <dbReference type="EnsemblBacteria" id="AKH82727">
        <property type="protein sequence ID" value="AKH82727"/>
        <property type="gene ID" value="AA958_11360"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_11360"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2390"/>
    <dbReference type="OrthoDB" id="256504at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016868">
        <property type="term" value="F:intramolecular transferase activity, phosphotransferases"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="SSF55957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGM_PMM_I" evidence="6">
        <location>
            <begin position="8"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_II" evidence="7">
        <location>
            <begin position="156"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_III" evidence="8">
        <location>
            <begin position="263"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_IV" evidence="5">
        <location>
            <begin position="374"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH82727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="452" mass="47618" checksum="FC4D9174253CB594" modified="2015-07-22" version="1">MTDLSAIVKAYDVRGVFPEQLDEPLVELFGAAFTETTGAGKIVVGHDMRPSSPALAAAFARGAVGRGADAVLIGLCSTDQLYFASGHLGLPGAMFTASHNPARYNGIKMCRAGAAPVGQDTGLAEIRATVERWQAEGAPAPVAKPGSVTQTDLLADYAAHLRSLVDLGAIRPLKVVVDAGNGMAGHTVPSVFDPLPVDVVPLYFELDGTFPNHEANPLDPKNIVDLQAEVRRTGADAGLAFDGDADRCFVVDEKGDPVAPSAITALVAARELERNGGGTIIHNLITSWSVPEVVKEHGGTPVRTRVGHSFIKEEMAKTGAIFGGEHSAHYYFRDFWNADTGMLAALHVLAALGGQDGPLSQLVAAYDRYAASGEINSTVDDQDARLAAVRAAYAGREGVTIDELDGLTATGDGWWFNLRASNTEPLLRLNVEAGDAETMARVRDEALALVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7Q3</accession>
    <name>A0A0F7N7Q3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Multidrug ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_15770</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016736.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_15770"/>
    <dbReference type="EnsemblBacteria" id="AKH83424">
        <property type="protein sequence ID" value="AKH83424"/>
        <property type="gene ID" value="AA958_15770"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_15770"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3324"/>
    <dbReference type="OrthoDB" id="1833499at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="8"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH83424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="313" mass="32616" checksum="EE1678FFE5B3EC16" modified="2015-07-22" version="1">MAASEATIEVRELRKRFGPVAAVDGLSFTVVPGQVTGFVGPNGAGKSTTMRVVLGLDAPDAGSALVGGRPYAALRRPLQHVGAALDAAAVHPSRRGRDHLLWLAHSHGLPPRRVDELLEQVGLASAARRRAGGYSLGMRQRLGIAAALLGDPPVLLFDEPVNGLDPEGIRWIRGFLRRLAAEGRAVLVSSHLMSELEDTADHLVVIGRGRLVADMPVAEVLAAASDSRVALRTGARERAMTVLAAAGATVAATGRESLTVSGLPAERVAELLGAGAVPFSELAAHRASLEEAYMELTRGEAEFAAGPEGEGPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7R0</accession>
    <name>A0A0F7N7R0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_16010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016775.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_16010"/>
    <dbReference type="EnsemblBacteria" id="AKH83463">
        <property type="protein sequence ID" value="AKH83463"/>
        <property type="gene ID" value="AA958_16010"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_16010"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3373"/>
    <dbReference type="OrthoDB" id="1303819at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519288" evidence="2">
        <location>
            <begin position="30"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH83463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="393" mass="40212" checksum="9D80E534C9665577" modified="2015-07-22" version="1">MRRRSFVSGLAATTAATGLGLTAAGHGHAAATAPAPTDGRSGRGAGPRAAWREVPVPAGAPAVLLSAVAAAGPDLAWAVGEEARSGSTSGRPVARAWDGSGWQATDVSHLAFAGSIRNVAAAPAGAAVAAWAVAYDRAGADHLLAWDGATWREHDFPGRGESGTELWAVAVAPDGTVRISGTRDGASRVLRSGDAAGTRWSWSPPLPTDDGSVPSLWNVHVDRAGATWVSGDVVVARYDDRSWLVLPRLAGLRLSVTDLLPVAPDDIWLTGHDYGAGGPPGKPPSVVLRHYDGTAWSDIAAPFTVGSLGAIAPDAAGGPALIAGWDFWDGTSAHYLRWDGTAWTSERGPVAAQGTTPVMSALAPIPGTAGFWSAGTTAQSPFPPAQARIERYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7X5</accession>
    <name>A0A0F7N7X5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_23590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017950.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_23590"/>
    <dbReference type="EnsemblBacteria" id="AKH84695">
        <property type="protein sequence ID" value="AKH84695"/>
        <property type="gene ID" value="AA958_23590"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_23590"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4972"/>
    <dbReference type="OrthoDB" id="1544298at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="237" mass="25203" checksum="FB95ADEADA4ABC83" modified="2015-07-22" version="1">MEGTSLGELWDRVVGTQPDPSEWLVVVTGLVALSVVLPWGIWRVARNAVTIAHEGGHGLVAVLTGRRLEGIRLHSDTSGLTVSRGKPSGLGMVLTAASGYTAPPLLGLAGAWLLADGRITAALWGAIALLAAMLLMIRNAYGVVTVVLTGAAFFLVSWLTEPDVQAAFAYGAVWFLLLGGVRPVFELQRKRRRGEAPQSDADQLGRLTHTPAGLWVFLFYVVALCALAGGARWLLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7Y7</accession>
    <name>A0A0F7N7Y7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-oxoisovalerate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_16525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016853.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_16525"/>
    <dbReference type="EnsemblBacteria" id="AKH83548">
        <property type="protein sequence ID" value="AKH83548"/>
        <property type="gene ID" value="AA958_16525"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_16525"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3478"/>
    <dbReference type="OrthoDB" id="900125at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transket_pyr" evidence="1">
        <location>
            <begin position="6"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="326" mass="35396" checksum="BCE80260C59A9EFD" modified="2015-07-22" version="1">MAVEKMALAKAINASLRTAMEDDAKVLVIGEDVGKLGGVFRVTDGLQKDFGEDRVIDSPLAESGIVGTAIGLALRGYRPVVEIQFDGFVFPAYDQIVTQLAKMHARALGRVKLPVVIRIPYGGGIGAVEHHSESPEALFAHVAGLKCVSPSTPADAYWMLQQAIHSDDPVIFFEPKRRYWDKGEVNTSAIPGPLHEARVAREGTDLTLAAYGPMVKTCLEVASAAAEEGTSLEVVDLRSMSPIDFDTLQRSVEKTGRLVVVHEAPVFYGSGGEIAARITERCFYHLEAPVLRVGGFHAPYPPARLEEEYLPNLDRVLDAVDRALAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N844</accession>
    <name>A0A0F7N844_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">6-phosphofructokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_16915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016917.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_16915"/>
    <dbReference type="EnsemblBacteria" id="AKH83613">
        <property type="protein sequence ID" value="AKH83613"/>
        <property type="gene ID" value="AA958_16915"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_16915"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3559"/>
    <dbReference type="OrthoDB" id="1832160at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HATPase_c" evidence="1">
        <location>
            <begin position="15"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="132" mass="13986" checksum="384349186EDB063E" modified="2015-07-22" version="1">MTTQARMFARSARSVGRAREFVAGVVGAGDRADDIRVCVSELATNALRHTPVGRRFLVRVAVQPHVVQVEVHDPGDGEPHVCSPADTDDRGRGLLLVEALADDWGTSARNGPGKSVWATFKVSGAPEGAAGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N945</accession>
    <name>A0A0F7N945_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Site-specific DNA-methyltransferase (cytosine-N(4)-specific)</fullName>
            <ecNumber evidence="3">2.1.1.113</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_14655</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = an N(4)-methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:16857"/>
            <dbReference type="Rhea" id="RHEA-COMP:11369"/>
            <dbReference type="Rhea" id="RHEA-COMP:13674"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:85452"/>
            <dbReference type="ChEBI" id="CHEBI:137933"/>
            <dbReference type="EC" id="2.1.1.113"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the N(4)/N(6)-methyltransferase family. N(4) subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.113" evidence="3"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016577.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_14655"/>
    <dbReference type="REBASE" id="113747">
        <property type="entry name" value="M.Ssp509ORF14655P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH83262">
        <property type="protein sequence ID" value="AKH83262"/>
        <property type="gene ID" value="AA958_14655"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_14655"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3087"/>
    <dbReference type="OrthoDB" id="1071106at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015667">
        <property type="term" value="F:site-specific DNA-methyltransferase (cytosine-N4-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017985">
        <property type="entry name" value="MeTrfase_CN4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00093">
        <property type="entry name" value="N4_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH83262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="426" mass="46696" checksum="844DE89B3E7EBC1E" modified="2015-07-22" version="1">MRSDTRQNAHLTYRANAGAGRHGWLRLTPAYSVSLVRRYAAEMPPGSVVTDPFSGTGTTPLAAAEHGLTGQSLDVNPFLIWLGKMKTAAYEPDHLRETRRALAPLVHRAEELLPAAGELWQPELHNIGRWWARSALDALKAIRRALDVAAGALPPGGRDLLDVAFCRTLIASSNAAFNHQSMSFKEDRTGGDSTLQLLDPDAARAVLETFRREAGTTLANAATPLPGTARVLYGDSRDMQPAAGRLTPCDLLLTSPPYVNRMSYIRELRPYMYWMRHLRRAEDAGRLDWQAIGGTWGAATSRVRAWRPPGPDAGGVPEPVAGELARTQAAIRRDGGRNGPLLANYVGKYMHDMWGHFRAAYKNVRGGGRVVYVIGNSTFYGNQVPAQEWYAALLREVGFAGVEVEVIRKRNSNKALFEYAVSGGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N990</accession>
    <name>A0A0F7N990_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Integrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_19495</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017292.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_19495"/>
    <dbReference type="EnsemblBacteria" id="AKH83999">
        <property type="protein sequence ID" value="AKH83999"/>
        <property type="gene ID" value="AA958_19495"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_19495"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4103"/>
    <dbReference type="OrthoDB" id="785253at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="4">
        <location>
            <begin position="300"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="33"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH83999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="521" mass="57897" checksum="478310EDA66E9AAF" modified="2015-07-22" version="1">MATARRGGGITKRCECRGDNGKLLGAQCPQLARKNHGRPSVRQELPPGEGGGRRTFRRTGYDTVTDAQADLDRLRTILDLPGDDEDAARRVGDLLADIAKHRAPIPKPEEVSRRLGIGIPLNGKRTVGDLLDAWLAAKRKARRPGTTNGYDGHVRNYLRPALGHYRSDRLGVQAVQDMFDEIAERNDVIRAENEARREQVERCKWTKPGRPPAAQRERLAVEKALLAEMKPFRRIADLGTQHAIRRSLRAALNWAMARPEYGVTFNAAAHVELTTYRRPRGLLWTQERVQRWRQTGEIPSKVMVWRPDQLGQFLDAAESSRHYVGFLLVGYHAMRRSEAAGAAWEDLDAQARVLMVSTAVTVDGWTPVESEPKTDGSAAPVSLDSGTVAVCGEHRKRQLAERDARLAAGLPWTDSGKILTNEDGTPIHPHVLSDEFERIRDRADLPPITLRDLRHVGAGLVKAAGGDIDDAKVKLRHQSVRLTSDTYMVMFQEMEQTLAEGVVAVVPRARKSDGENASKPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9A6</accession>
    <name>A0A0F7N9A6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_15095</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016637.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_15095"/>
    <dbReference type="EnsemblBacteria" id="AKH83322">
        <property type="protein sequence ID" value="AKH83322"/>
        <property type="gene ID" value="AA958_15095"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_15095"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3181"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH83322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="284" mass="28038" checksum="47BC5EF557C5E2F5" modified="2015-07-22" version="1">MTTIYCPRCDSRHDPAGAPWCAQPRDVPAVPEIYGTLGAPAQLPAGAPNGPAPTDLELFDDHDRTAALPAVPEAAYGGDGVGAELVPVRPRSRHRRYKRRSRRLAGLAAAGMTVLSGGLLAANAMGGGGGARTDEAVARTDTPVQPLPSEEPGGDGGAGQDGDRPSGAAKPDGAEPAGPRTGPTKAARDADRPAESPAPTKDSPAPTTTTPAEGRVTAPDTAEPESSSPSTGTPTPTPSNEGDTDGGSGGSGGSGGSGDSGGGSAEDSDHGGLELDLPLLPGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9C6</accession>
    <name>A0A0F7N9C6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ROK family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_19735</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_19735"/>
    <dbReference type="EnsemblBacteria" id="AKH84039">
        <property type="protein sequence ID" value="AKH84039"/>
        <property type="gene ID" value="AA958_19735"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_19735"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4159"/>
    <dbReference type="OrthoDB" id="1130699at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH84039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="301" mass="30316" checksum="3E3F10E8AB39FA32" modified="2015-07-22" version="1">MGGTGMKAALVGADGALLHETRRPTPREAGPEAVVAAVLDFAAELRDIGVEKYGEPAVAAGVAVPGIVDDAEGVAVFSANLGWRDVPFRRLLGERLACPVAVGHDLRTGGLAEGRLGAARDVDRFLFIALGTGIAAAIGIEGRIEPGAHGGSGEIGHVVVRPDGPPCGCGQRGCLERLASASAVGEAWATACGDPGVTAADCAEAVEAGDPLAEAVWQDAVDALAGGLITGITLLDPRRIVVGGGLAEAGDTLFVPLTRAVRARITFQTFPQIVPAELGDAAACLGAGQLAWDLLATEVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9I9</accession>
    <name>A0A0F7N9I9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GTPase HflX</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">GTP-binding protein HflX</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">hflX</name>
        <name evidence="11" type="ORF">AA958_26610</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer. Associates with the 50S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="5">May associate with membranes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018447.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_26610"/>
    <dbReference type="EnsemblBacteria" id="AKH85210">
        <property type="protein sequence ID" value="AKH85210"/>
        <property type="gene ID" value="AA958_26610"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_26610"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5599"/>
    <dbReference type="OrthoDB" id="1592033at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01878">
        <property type="entry name" value="HflX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00900">
        <property type="entry name" value="GTPase_HflX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030394">
        <property type="entry name" value="G_HFLX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032305">
        <property type="entry name" value="GTP-bd_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016496">
        <property type="entry name" value="GTPase_HflX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025121">
        <property type="entry name" value="GTPase_HflX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042108">
        <property type="entry name" value="GTPase_HflX_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10229">
        <property type="entry name" value="PTHR10229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16360">
        <property type="entry name" value="GTP-bdg_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13167">
        <property type="entry name" value="GTP-bdg_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006809">
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
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</entry>
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
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                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">CNQ-509</strain>
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</entry>
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</entry>
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                <person name="Kalinowski J."/>
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                <person name="Kaysser L."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <sequence length="448" mass="46498" checksum="B5256FA1AFF76229" modified="2015-07-22" version="1">MLNAMPVVRDLRSLLRLHGFRRLLAVRLLSQGADGVYQVALAAYVVFSPERQTSPAAIASAMAVLLLPYSLVGPFAGVLLDRWRRRQVLLYGNLLRAVFAAGTAALLLAGVPDWLFYLSALSVTAVNRFVLSGLSAALPRVVDTEEQLVVGNSLSPTAGTLAATAGGGVAFLVGLAGPKGGTADALTVLVGSGLYLCAAVASLRMAPGALGPDPELVLPRIRAAVASTARGLVAGVRHLRERREAAQALSAMALMRFCFGALTVMLLMLCRYAWSDGEDDGMALLGVAVGLSGVGFFVAAVVTPSLVTRLGRSGWMTLCAALAAVLTPVLALSFAPGPMLVAAFVLGVTTQGVKITTDTVVQSSVDDAYRGRVFSLYDMLFNVAFVGAAAAASALLPADGRSALLVAGVSVIFAVIALSMFHVKHVPVEQEHPPVLEGGAEPHVSRET</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NA66</accession>
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    <organism evidence="2 3">
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_27990"/>
    <dbReference type="EnsemblBacteria" id="AKH85440">
        <property type="protein sequence ID" value="AKH85440"/>
        <property type="gene ID" value="AA958_27990"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_27990"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5899"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="16"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="159" mass="16833" checksum="AA1941A5C3B40C7A" modified="2015-07-22" version="1">MLALLDGAVAWLTGQGRTGQWGTEPFSGLPERVAQMEEYARDFLVRVAETPAGGVAGVCVLADEPQSFVPAAGEPELYVRLLVTDRALRGAGVGAALVADARAEAVRRGVGLLRVDCFGGGDGALARQYERLGFTPSGTFAVERPGRPVWPGRLLEIRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NA83</accession>
    <name>A0A0F7NA83_9ACTN</name>
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        <submittedName>
            <fullName evidence="1">Endoribonuclease L-PSP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_16960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016926.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH83622">
        <property type="protein sequence ID" value="AKH83622"/>
        <property type="gene ID" value="AA958_16960"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_16960"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3568"/>
    <dbReference type="OrthoDB" id="1850770at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
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    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="PTHR11803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="SSF55298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH83622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="129" mass="13639" checksum="0B81F1ECA6C7DD1A" modified="2015-07-22" version="1">MQHIVRPDGSPPVNGYSHAVTFTGTMVAVSGQVPLDEAGRLVGENDAEAQVRQVFANLTTALRAAGSGLEHVVKLTVYLTDLDDLPAFRRVRDEIQNPALPPASSLVQVAGLVSPEFRVEVDALAVVPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAP8</accession>
    <name>A0A0F7NAP8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_22640</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017792.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH84534">
        <property type="protein sequence ID" value="AKH84534"/>
        <property type="gene ID" value="AA958_22640"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_22640"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4763"/>
    <dbReference type="OrthoDB" id="2028133at2"/>
    <dbReference type="Proteomes" id="UP000034283">
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519440" evidence="2">
        <location>
            <begin position="36"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH84534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="423" mass="43978" checksum="4E6D6C5294404CC7" modified="2015-07-22" version="1">MGTSGEARRPGALRARGVAAAALGAVVLLAGTAACSPGGGDGPGEESPAGSREGSRGGSPTAAPPTGAPVRDRACEVELPDGWSDALAAGRVPVPEGERAVLTEVGPGAGWSVLQSSGADRSIVLREGDEERRVMRLADPVEHQVGSADFDGRWLVFDVVEGRQVESPWTLYAWDDTSGRRKAVAEAERAADGQSAVPGPFVQAVVRSGRLFWAQGTGGGRSAVYARDLGGGGERRTVYEGVVDTPFAAGGLLVWLRQSESPSGGPETRLAAVSTDTLRRAELPGPIAALRNVRYVASDGRTWAWAGGEPERPRLYVWREGWPKPLPLVRGGGGGAAAEPELGGIDQVQVSGEVVTWRTTEAAWALDLRSRTYARITPGYGYALARDGGLGVAYPEGEAKAADARDAIQLTETATLPALPGCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAQ5</accession>
    <name>A0A0F7NAQ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_22875</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017830.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_22875"/>
    <dbReference type="EnsemblBacteria" id="AKH84573">
        <property type="protein sequence ID" value="AKH84573"/>
        <property type="gene ID" value="AA958_22875"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_22875"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4817"/>
    <dbReference type="OrthoDB" id="1808614at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH84573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="231" mass="25620" checksum="FDBDE98FC6674EA2" modified="2015-07-22" version="1">MSEQSAAVEQLLAGAGEMMLAGRRRFDVAAGLRRLREGPAGYTGPGTDASPVVQARDELSVLVRWTVNRAGARGFVGRLASLLSDHGPQCHEAWLEVPDIDGAIRGMQVFACMLYQADHRESAQFWWQLAAGAGSRAAAYCLHLHHLGLGEPAEAGHWRTQLQEDGGPDDEFISGVSLFADYVDRNCEPGWEPHMHREIQRLASREDVRDALVCRPESEIADRFQRYCEQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NB05</accession>
    <name>A0A0F7NB05_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">YCII domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_18400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the YciI family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017150.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_18400"/>
    <dbReference type="EnsemblBacteria" id="AKH83852">
        <property type="protein sequence ID" value="AKH83852"/>
        <property type="gene ID" value="AA958_18400"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_18400"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3863"/>
    <dbReference type="OrthoDB" id="1780176at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005545">
        <property type="entry name" value="YCII"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03795">
        <property type="entry name" value="YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YCII" evidence="2">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH83852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="183" mass="20207" checksum="30D53BE1E004E480" modified="2015-07-22" version="1">MEFFCYHRDRPGSLELRYELLEEHWSYMDRYAAEMIARGPTTAGDGEVPTGSVHILDLPDPAAARAFAFGEPGWQAGAYRDVMLRRWRNALGRTMWDFPGGRTGGDRYLVLGLGAGEAVDLDLPRERDELIAYGPLLSDDGDRWLGTAALLRAPDAAAARAVLTAAAYAAVEVHDWHFGGRPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBA2</accession>
    <name>A0A0F7NBA2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">OmpR/PhoB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_30215</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AfsR/DnrI/RedD regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019013.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_30215"/>
    <dbReference type="EnsemblBacteria" id="AKH85785">
        <property type="protein sequence ID" value="AKH85785"/>
        <property type="gene ID" value="AA958_30215"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_30215"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6380"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15831">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="298"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH85785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="330" mass="36561" checksum="C6E0123F03510E8E" modified="2015-07-22" version="1">MEFRILGSVEVHDERTGLRMVPGGAKQRALLGALIAKANRPVRARQLIDELWVQTPPANKANALQAHIRRLRRLLPPSRPGEPQREWITTCAAGYALRLGGAATDAGRFRRAALEGRSLLDRDPEQAARLLRRALACWRGPVLEGASLDMCAGEVAQLEEARLVALEALYEACLRTRRHHEITSELTELTVRHPLRERFYDLLMVALCRCGRQADALSVYDRARARLARELGIEPGPVLRGRLRAVLDHDSALYPPDFAGHSERLAVATEPLLGARDPGALTDAAAAGGGDRALHVEIASMRRHLDRLTRDHQALLQRFDQFTARPAGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBG5</accession>
    <name>A0A0F7NBG5_9ACTN</name>
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        <submittedName>
            <fullName evidence="3">Myo-inositol-1-phosphate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_24240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the myo-inositol 1-phosphate synthase family.</text>
    </comment>
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    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_24240"/>
    <dbReference type="EnsemblBacteria" id="AKH84809">
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        <property type="gene ID" value="AA958_24240"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_24240"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5108"/>
    <dbReference type="OrthoDB" id="669352at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004512">
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006021">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002587">
        <property type="entry name" value="Myo-inos-1-P_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013021">
        <property type="entry name" value="Myo-inos-1-P_Synthase_GAPDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="PTHR11510"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01658">
        <property type="entry name" value="Inos-1-P_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07994">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015578">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inos-1-P_synth" evidence="2">
        <location>
            <begin position="214"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH84809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="381" mass="39016" checksum="6A67B249D24603A5" modified="2015-07-22" version="1">MRVGIWFIGARGSVATTAVVGGLALRAGLTEPVGCVTAHPDLAAGALPGFGDLVFGGHDVNTGTVAKKAEQLAAAGVVPARLVQALEADLAEAEAELRHAPAGGTQAETAAAVVADIEAFAERHALERVVVVNVASTEPAAQPHPAHADLAALDAALAAPGRVLPPSSLYAYAAFTAGCAYVDFTPSTGARLPALDELAAARGLPYAGHDGKTGETLLKSVLAPMFAMRNLAVRSWSGLNLLGGGDGANLAEPGANAAKSVSKQRVLRETLGYAPEGDTHIDYVADIGDFKTAWDLITFGGFLGTPMRLQFTWEGCDSALAAPIVLDLARISLAAHAAGRTGPLTPLAFFFKDPLGDGDHALHAQWAELRAFVAGLDGDGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBH6</accession>
    <name>A0A0F7NBH6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-alpha-hydroxysteroid dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_24355</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018075.1">
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    </dbReference>
    <dbReference type="SMR" id="A0A0F7NBH6"/>
    <dbReference type="STRING" id="444103.AA958_24355"/>
    <dbReference type="EnsemblBacteria" id="AKH84823">
        <property type="protein sequence ID" value="AKH84823"/>
        <property type="gene ID" value="AA958_24355"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_24355"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5132"/>
    <dbReference type="OrthoDB" id="1356861at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH84823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="256" mass="26117" checksum="90D91617372DB979" modified="2015-07-22" version="1">MSGLQDKVVIVTGGGGGLGRAVVARLARDGAAVVVTGRGSEQGEKTAAEAGGIFLRHDVTSEDDWTAVVDAVVGRYGRLDGLVNNAGVDSWSLIEDESLEKFEQVVKVNLTGVFLGVKAVVPAMRAAGGGSIVNVGSATGLNGHPMTAGYGASKWGARGLTKTAAVELGRYRIRVNSVHPGLVYTPMTAANGAKPGEGNFPFAPLNRLGTPEEIGEAVAFLVSDAASYMTGADISVDGGWSAGETALMKHAPDPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBL9</accession>
    <name>A0A0F7NBL9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">XRE family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_28775</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018809.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH85576">
        <property type="protein sequence ID" value="AKH85576"/>
        <property type="gene ID" value="AA958_28775"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_28775"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6064"/>
    <dbReference type="OrthoDB" id="705269at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041413">
        <property type="entry name" value="MLTR_LBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17765">
        <property type="entry name" value="MLTR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="34"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH85576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="289" mass="31303" checksum="0566A2D9808DE4A7" modified="2015-07-22" version="1">MTTSGLPVTPGTPAGGTPRTGGPDDGAATAGALLRNWRERRGLSQLELALRADSSARHISFVETGRSRPSRAMVLKLAEHLDMPVRERNALLLAAGHAPHYPETPLDDPAMAELRQGVEQLVAAHEPFPAVVVDGAYTVVAANRGILLVLDEVPEELLRPPLNAMRLTLHPDGLAKKIRNLPQWRAHLLHQMDRQLSLVRSPALKELYDEVAAYPLPPEAGDEVVEEVGGRAPFALPLQVAHDGHLLSFVSTISTFNTPMDVTVSELALETLLPADPETTKYLRQQLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBN9</accession>
    <name>A0A0F7NBN9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glucoamylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_20270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017421.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_20270"/>
    <dbReference type="EnsemblBacteria" id="AKH84132">
        <property type="protein sequence ID" value="AKH84132"/>
        <property type="gene ID" value="AA958_20270"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_20270"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4268"/>
    <dbReference type="OrthoDB" id="318658at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011613">
        <property type="entry name" value="GH15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045582">
        <property type="entry name" value="Trehalase-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19291">
        <property type="entry name" value="DUF5911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00723">
        <property type="entry name" value="Glyco_hydro_15"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5911" evidence="2">
        <location>
            <begin position="7"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_15" evidence="1">
        <location>
            <begin position="232"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_15" evidence="1">
        <location>
            <begin position="340"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH84132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="639" mass="69472" checksum="5AD390E721179CE8" modified="2015-07-22" version="1">MTPGPYPPIADHGIIGDLQTVALVSAEGVVDWLCAPRFDSPSVFGALLDAGRGGRFALTADAPDAVPRQIYLPGTAVLVTRFLSTGGIGEVLDFMPVDHPERPTDTHRVIRLVRALRGPMRFTLDCSPRFDYGRDPHRLELDGRTARFRSATAEGHLQLLGPAGDLTREGDDVRAVLELAQGRTAAAVFTVCAPGADPPPPAYERDVHRELSKVRAYWHRWTARCTYRGRWREVVTRSAITLKLLTYAPTGAPVAAATMGLPEQVGGERNWDYRYTWIRDASLSVGALLDLGYAAEADAYRRWLGELLGAAHAARSATGTGAAADGAGGTPRGTVTGEPLQVMYRVDGDPRLPEEILPHWEGYRRSAPVRAGNAAAGQLQLDIYGEAVYALAQASRTAGPAGYDAWRCLAALLDWLTDHWDRPDEGIWETRGGPQDFTYSRLMCWVAFERGLRMATELSRPADVARWTAARDAVFEQVMEHGYSPRRQAFVQHYGSDVLDASLLLMPLVGFVAPAEPRWLSTLRAMEAELVTDSLVHRYDPSAAPDGLRGSEGTFSLCSFLYVSALAGAGHVDRARYAFDKMLTYANHVGLFAEEIGPTGEQLGNFPQAFTHLALIVAALTLDEALDAAEREGGTAAHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBP0</accession>
    <name>A0A0F7NBP0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Xylose isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_28910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018834.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_28910"/>
    <dbReference type="EnsemblBacteria" id="AKH85601">
        <property type="protein sequence ID" value="AKH85601"/>
        <property type="gene ID" value="AA958_28910"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_28910"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6091"/>
    <dbReference type="OrthoDB" id="537203at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018246">
        <property type="entry name" value="AP_endonuc_F2_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00730">
        <property type="entry name" value="AP_NUCLEASE_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="65"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="392" mass="42233" checksum="02F48FFB858EE746" modified="2015-07-22" version="1">MRFRHPDGSLVHLAYCTNVHPAEDLDGVMAQLRDHAEPVRRRLGRDRLGIGLWLARDAVRTLGSDPAALRRLRKALDERGLEAVTLNGFPYQGFGDEVVKYRVYRPDWTEPERLDHTVELARLLAALLPDDVTEGTISTLPLAWRTDFDDAARKASLTALGTLAARLDAIEELTGRSIRVGLEPEPGCTVETTADAVAALTAEGAPPPERIGVCVDTCHLATSFEDPATAIAGITGAGLPIVKSQLSAALVADRPADPGVRTALAAFAEPRFLHQTRIRAADGTVRATDDLDEALAGGLPDDGPWRAHFHVPLHAPLEPPLTATTPVLEETLARLVGGPAPLTRHLEVETYTWQALPAHLRPRSRAQLADGIAAELSVARDLLTSLGLKELP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBU2</accession>
    <name>A0A0F7NBU2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Demethylmenaquinone methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.163</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">menG</name>
        <name evidence="5" type="ORF">AA958_20565</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 2-demethylmenaquinol + S-adenosyl-L-methionine = a menaquinol + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42640"/>
            <dbReference type="Rhea" id="RHEA-COMP:9539"/>
            <dbReference type="Rhea" id="RHEA-COMP:9563"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18151"/>
            <dbReference type="ChEBI" id="CHEBI:55437"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.1.1.163"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Quinol/quinone metabolism; menaquinone biosynthesis; menaquinol from 1,4-dihydroxy-2-naphthoate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.163" evidence="4"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017469.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_20565"/>
    <dbReference type="EnsemblBacteria" id="AKH84182">
        <property type="protein sequence ID" value="AKH84182"/>
        <property type="gene ID" value="AA958_20565"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_20565"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4338"/>
    <dbReference type="OrthoDB" id="1431378at2"/>
    <dbReference type="UniPathway" id="UPA00079">
        <property type="reaction ID" value="UER00169"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043770">
        <property type="term" value="F:demethylmenaquinone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102094">
        <property type="term" value="F:S-adenosylmethionine:2-demethylmenaquinol methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102955">
        <property type="term" value="F:S-adenosylmethionine:2-demethylmenaquinol-7 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102027">
        <property type="term" value="F:S-adenosylmethionine:2-demethylquinol-8 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01813">
        <property type="entry name" value="MenG_UbiE_methyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004033">
        <property type="entry name" value="UbiE/COQ5_MeTrFase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023576">
        <property type="entry name" value="UbiE/COQ5_MeTrFase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01209">
        <property type="entry name" value="Ubie_methyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01934">
        <property type="entry name" value="MenG_MenH_UbiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51608">
        <property type="entry name" value="SAM_MT_UBIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01184">
        <property type="entry name" value="UBIE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="1 4 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0830">Ubiquinone</keyword>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="4">
        <location>
            <begin position="102"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH84182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="231" mass="25219" checksum="F98A455D10FF2637" modified="2015-07-22" version="1">MTRATLEKQPHEVAAMFDDVAANYDLTNDVLSLGQARLWRKAVARAVDARPGQRVLDLAAGTGTSSLPFTAAGAYVVPCDFSLGMLREGRRRHPRLPLTAGDATRLPFADGVFDAVTISFGLRNVQETAAALREMRRVTRPGGRLVICEFSHPTWAPFRTVYTEYLMRALPPIAERVSSSPDAYVYLAESIRAWPDQPALAAELGAAGWTRPAWRNLSGGIVALHRAYAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBW2</accession>
    <name>A0A0F7NBW2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_25055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018185.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_25055"/>
    <dbReference type="EnsemblBacteria" id="AKH84934">
        <property type="protein sequence ID" value="AKH84934"/>
        <property type="gene ID" value="AA958_25055"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_25055"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5280"/>
    <dbReference type="OrthoDB" id="1744037at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023187">
        <property type="entry name" value="Tscrpt_reg_MarR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01117">
        <property type="entry name" value="HTH_MARR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="25"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="168" mass="18554" checksum="43CE3A5CB31FA3EB" modified="2015-07-22" version="1">MPKPLSLSFDPIARADELWRQRWGAVPAMGAITSVMRAHQILLAQVDAVVKPYGLTFARYEALVLLTFSKAGELAMSKIGERLMVHPTSVTNTVDRLVKSGYVAKRPNPNDGRGTLASITDRGREVVEQATRDLMAMDFGLSAYDEEQCAEIFAMLRPLRIAAGDFEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NC60</accession>
    <name>A0A0F7NC60_9ACTN</name>
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        <submittedName>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_25410</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_25410"/>
    <dbReference type="EnsemblBacteria" id="AKH84998">
        <property type="protein sequence ID" value="AKH84998"/>
        <property type="gene ID" value="AA958_25410"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_25410"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5356"/>
    <dbReference type="OrthoDB" id="1734230at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025966">
        <property type="entry name" value="OppC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12911">
        <property type="entry name" value="OppC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="121"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="251"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="298"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="120"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH84998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="332" mass="35654" checksum="8EBC848387710545" modified="2015-07-22" version="1">MTAPIETTGATEATPEALVEGVDKSRIEGRSLGRIAWMRLKRDRVAMAGGVVVVLLILIAALSRPIQSVFGLDPNKLNQDLVDPSLATPYGSFGGMSWDHPLGVEPRLGRDIATRILEGSWVSLLVAFGATLVAVVIGTVLGVIAGYYGKWADTIISRTMDTFLAFPVLLFAISISAALQGGAFGLKGLQLHIGVLIFVIGFFSWPYIGRIVRGQTLSLREREFVEAAKSLGARGPFILFRELLPNLVGPILVYSTLLIPTNILFEAALSFLGVGIQPPQASWGGMLSSAIDYYQVDPMFMVVPGVAIFLSVLAFNLLGDGLRDALDPKGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCD6</accession>
    <name>A0A0F7NCD6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cell division initiation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_25830</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018317.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_25830"/>
    <dbReference type="EnsemblBacteria" id="AKH85073">
        <property type="protein sequence ID" value="AKH85073"/>
        <property type="gene ID" value="AA958_25830"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_25830"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5440"/>
    <dbReference type="OrthoDB" id="1602369at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="141"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="206"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="48"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="221"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="249"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH85073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="394" mass="42504" checksum="1E40FAAC4C62CE9F" modified="2015-07-22" version="1">MDVQRKLDEIAEALQGARSMPMSASCVVNRAELLGMLNEVREALPGSLAQAQQLLGGREQLVEEARREAEQILDEAQNRRNALISDTEVARHAQAEADRILGEARQEAEQISAEADDYVDSKLANFEVVLTKTIGSVDRGRDKLLGRAPGYDDPQGFEAGQDPAGEAPERSADPQEQRRRADTYVEAQFQAFQSVLTKTLEAVGRGRQKLQGARPTDQLGETFGQPGTGHTGTTDESYLAELAELADPPPGPAHAPGAPRDPAIPPPPAQQPPHAAPQPAAAYYDVTAAQGYGQAGYPQPEQPDYPQSYGQGYPQGYEQPEPGYGWAQQAGQQEQAPAGAYPDAGQQVPYGHSDAHLPQQGGYTPAPAALDETSLFDTSMIDLEQLRQYDDRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCQ1</accession>
    <name>A0A0F7NCQ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_22390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_22390"/>
    <dbReference type="EnsemblBacteria" id="AKH84492">
        <property type="protein sequence ID" value="AKH84492"/>
        <property type="gene ID" value="AA958_22390"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_22390"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4714"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH84492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="136" mass="14257" checksum="2F32F6D1FEB28A2E" modified="2015-07-22" version="1">MNTTLAADLVPLAEELDKNKVTPGVLGFIVFALLGVAVWFLLKSMNRHLGKVDFKEKTDRGDAGPGGSRPEGEGPGDGGDPRDDKPRGDAPRGSAPRGDAPRGGAPRDDSPRGESPRTPAPAESPAADKQPVARRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCU8</accession>
    <name>A0A0F7NCU8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AA958_26545</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018435.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_26545"/>
    <dbReference type="EnsemblBacteria" id="AKH85198">
        <property type="protein sequence ID" value="AKH85198"/>
        <property type="gene ID" value="AA958_26545"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_26545"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5586"/>
    <dbReference type="OrthoDB" id="692375at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="5" id="KW-0808">Transferase</keyword>
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    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
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            <end position="193"/>
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            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="256"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AKH85198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="474" mass="51145" checksum="6C777AD244C8E24A" modified="2015-07-22" version="1">MRTRLLPLLIVLMAGMLLALGFPLADRIAGQEQQRVIVDRIDDTARFASLAQYVASRNEARPPSEDERLRALQEELHRYHDLYGIRAGVYYRDRSAMAAAPAGWRAMARAEGDRAFSESLAGRRSHDPPQVWPWQDDRLTVASPVVRDGDVVAVVVTDSPTGAMRSRTLTGWLWLGAGIAAAMTVAVAAAYRLTGWVLRPVRVLDKATHDIATGRLKSRVAAAGGPPELRRLAGSFNEMADNVESVLEQQRTFVADASHQLRNPLSALLLRIELLRLEAPQAAAEIDSVQAEGTRLARVLDDLLDLALAEHSPADLRVTDVARLAAERVASWRPLAEGQDVRLFLSGAPAVTGWADEVALSSALDAVVDNAVKFSPRCGEVEVRVDTAGDEVTVAVADRGPGLTDEELGRIGDRFWRSGRHQNVSGSGLGLSIARALLAAGGGRISYERNEPEGLRVTIAVPRTGPEGGVREGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCY8</accession>
    <name>A0A0F7NCY8_9ACTN</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_26765</name>
    </gene>
    <organism evidence="2 3">
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        <lineage>
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        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000034283">
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="160" mass="16776" checksum="3CB6458A164916A2" modified="2015-07-22" version="1">MAPEPGPGRAARPQARAPGRPAPRGSPADPRTRSGRHVRAATRARTAKAAPRPVRALRRPPEAARPRPGYPRTPAAPTPRRPRNAAGPPARAPTRPYPARPAPRAPRPPAHNRRTAGARRAPPGRPHALRASGGAGRLPGGFRAAAPVAVDCDLGHVDWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7ND67</accession>
    <name>A0A0F7ND67_9ACTN</name>
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            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_32570</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
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            <end position="80"/>
        </location>
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        <location>
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            <end position="141"/>
        </location>
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        <location>
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            <end position="165"/>
        </location>
    </feature>
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            <end position="196"/>
        </location>
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        </location>
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    </feature>
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            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH86171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="324" mass="35384" checksum="5575DC98A2B81F58" modified="2015-07-22" version="1">MVVEPGIAPQRTTDAPPRSTGELLRGLFRLSKLFVYQHYYGWGMAWLLLTPQARERPGTTLAMLLFLVGTMGVVTCTCSLDDLVGFRNGSDARNYNSGETKRNFSMKPLLSGRVTEREAVGFVSAAATVAILAGLGAFWALDWQAPLESYVLYGVMLCCIQYSGGMRLSYYPGGGEAALFLGTMSGLLAPFTAAQHEWSADAVLVAALLGLWLVMVSSYSNVNDVEGDRSVNRRTLAATAPKQVYKSAMVAFFVLSAGSTCLLAATERWPWWTLLTLLPALGLHLRQLREGPLREEWLTARRLGLYAFDLGFVGLLVPTLLVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7ND80</accession>
    <name>A0A0F7ND80_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_32695</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
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        </lineage>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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    </dbReference>
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        <property type="gene ID" value="AA958_32695"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_32695"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6908"/>
    <dbReference type="Proteomes" id="UP000034283">
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH86191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="125" mass="12496" checksum="7117A1478EBFE40D" modified="2015-07-22" version="1">MRSRPGALPRPPPRTTAGGFEEPDRHGEYGAERGAGAVEDPAGRGVACGREARHLPGSGGGRAAERGVPLADAEPGAGGLSGNRRNSDPGGTAAAAVLVALPVLIASLALQRRMISGMLAGAVRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7ND89</accession>
    <name>A0A0F7ND89_9ACTN</name>
    <protein>
        <submittedName>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_27630</name>
    </gene>
    <organism evidence="1 2">
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        <lineage>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018613.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_27630"/>
    <dbReference type="EnsemblBacteria" id="AKH85379">
        <property type="protein sequence ID" value="AKH85379"/>
        <property type="gene ID" value="AA958_27630"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_27630"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5822"/>
    <dbReference type="OrthoDB" id="1356861at2"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH85379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="258" mass="26884" checksum="4F98E5AC81E3035F" modified="2015-07-22" version="1">MPLQGRTALVTGVSREQGIGFAIARRLLADGTRVFAHGWTPHDDEMPWGADRGGTAAVTAALGGEGGRLAYAHADLAEPGAPAALLAAAGERYGMVDTLVVNHARSSTYDLDGLTAAELDLCWAVNVRATLLLVQAYAAQYDAAAGKERGGGRVVLFTSGQHLAPMSQEIPYAATKGALQQLTLTLSDALVDRGITVNCVNPGPTDTGWATDELAAQVGRALPRGTWNTPDEAAAVVDAATITGNTVDAESGFRRWVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDA9</accession>
    <name>A0A0F7NDA9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Proline dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_27450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018582.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_27450"/>
    <dbReference type="EnsemblBacteria" id="AKH85348">
        <property type="protein sequence ID" value="AKH85348"/>
        <property type="gene ID" value="AA958_27450"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_27450"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5784"/>
    <dbReference type="OrthoDB" id="1885467at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042204">
        <property type="entry name" value="2Fe-2S-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="85" mass="8934" checksum="4D12FA0D5182AC55" modified="2015-07-22" version="1">MSVRVDGEELVTEAGRTVAGLLLALGRVSWRTTRGGGRPRGVFCGIGVCHDCLVVVNGAADVRACQRLVRDGDDIRSQDGAELPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDF3</accession>
    <name>A0A0F7NDF3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AA958_33200</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019501.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_33200"/>
    <dbReference type="EnsemblBacteria" id="AKH86276">
        <property type="protein sequence ID" value="AKH86276"/>
        <property type="gene ID" value="AA958_33200"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_33200"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.7013"/>
    <dbReference type="OrthoDB" id="1110723at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003610">
        <property type="entry name" value="CBM_fam5/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036573">
        <property type="entry name" value="CBM_sf_5/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004236">
        <property type="entry name" value="Pept_S1_alpha_lytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001316">
        <property type="entry name" value="Pept_S1A_streptogrisin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035070">
        <property type="entry name" value="Streptogrisin_prodomain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02983">
        <property type="entry name" value="Pro_Al_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001134">
        <property type="entry name" value="Streptogrisin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00861">
        <property type="entry name" value="ALYTICPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00495">
        <property type="entry name" value="ChtBD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51055">
        <property type="entry name" value="SSF51055"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 9" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519425" evidence="7">
        <location>
            <begin position="28"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-3" evidence="8">
        <location>
            <begin position="402"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="234"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="262"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="343"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="301"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="337"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001134-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001134-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH86276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="448" mass="45665" checksum="8EA302200B6B8172" modified="2015-07-22" version="1">MLHKRVMGAAGATVAVGALVLAGLQGAAFGSDSPGTPGSASGQYSPGLLKAMQRDLGLTADQAERRLANESEAGAVAGTLRLSLGRSYGGAWVSGKTSAEVVVATTDATEARKIADEGARAKVVDHSLAELDAAKAGLDRIAERSSPAHVPVWYVDTTANRVVLHTSRPGAAERFAAAAGVDASLLKVRRSDEKPRTYADIVGGDAYYIGSGSRCSVGFSVNRGGQSGFVTAGHCGTAGATTTGVNRQAQGSFQGSTFPGRDYAWVGANSQWTPTPTVNGYGTGTKQVQGSTEAVERASVCRSGSTTGWHCGTIQQRNSSVTYPQGTVSPVTRTNVCAEPGDSGGSFISGTQAQGMTSGGSGNCSSGGTTYFQPVNAALQVYGLTLTTGDGGPTDPPTDPPGGTWAAGTVYQAGDTVTYGTTTYRCLQGHQAMPGWEPPNVPALWQAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDJ2</accession>
    <name>A0A0F7NDJ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">(2Fe-2S)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_28270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018723.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_28270"/>
    <dbReference type="EnsemblBacteria" id="AKH85489">
        <property type="protein sequence ID" value="AKH85489"/>
        <property type="gene ID" value="AA958_28270"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_28270"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5959"/>
    <dbReference type="OrthoDB" id="1843415at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002888">
        <property type="entry name" value="2Fe-2S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036884">
        <property type="entry name" value="2Fe-2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01799">
        <property type="entry name" value="Fer2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47741">
        <property type="entry name" value="SSF47741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH85489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="156" mass="16345" checksum="247DB29D98C94C1F" modified="2015-07-22" version="1">MRVTFTVNGREQQADDVWEGESLLYVLRERMGLPGSKNACEQGECGSCTVRLDGVPVCACLVAAGQAEGREVVTVEGLAEDGLSAVQQAFVDAGAVQCGFCTPGLLVAADDLLEHNPSPSDADIREGLSGNLCRCTGYEKILDAVRLAAARRGEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NE07</accession>
    <name>A0A0F7NE07_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_12495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019990.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_12495"/>
    <dbReference type="EnsemblBacteria" id="AKH86715">
        <property type="protein sequence ID" value="AKH86715"/>
        <property type="gene ID" value="AA958_12495"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_12495"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2625"/>
    <dbReference type="OrthoDB" id="1253502at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030802">
        <property type="entry name" value="Permease_MalE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30188">
        <property type="entry name" value="PTHR30188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02405">
        <property type="entry name" value="MlaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="249" mass="26079" checksum="30A0030DCE11F0A8" modified="2015-07-22" version="1">MRETGKLFALALSVARLSFKRPFQFREFVEQFWFIASVTILPAALVSIPFGAVIALQVGSLTQQFGAQSFTGGASVLAVIQQASPLIVALLISGAGGSAICADLGSRKIREELDAMEVMGVSPVQRLVVPRVLATMGVAVLLNGLVSVVGTLGGYFFNVILQGGTPGAYLASFSALAQLPDLYISEIKALIFGFIAGIVAAYRGLNPRGGPKGVGDAVNQSVVITFLLLFFVNTVLTSIYLQVVPPKGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NEF9</accession>
    <name>A0A0F7NEF9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6 7">50S ribosomal protein L19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">rplS</name>
        <name evidence="8" type="ORF">AA958_25940</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6 7">This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6 7">Belongs to the bacterial ribosomal protein bL19 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018333.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_25940"/>
    <dbReference type="EnsemblBacteria" id="AKH85092">
        <property type="protein sequence ID" value="AKH85092"/>
        <property type="gene ID" value="AA958_25940"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_25940"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5462"/>
    <dbReference type="OrthoDB" id="1698718at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00402">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038657">
        <property type="entry name" value="L19_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001857">
        <property type="entry name" value="Ribosomal_L19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018257">
        <property type="entry name" value="Ribosomal_L19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15680">
        <property type="entry name" value="PTHR15680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01245">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002191">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00061">
        <property type="entry name" value="RIBOSOMALL19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01024">
        <property type="entry name" value="rplS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01015">
        <property type="entry name" value="RIBOSOMAL_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 8" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH85092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="115" mass="13069" checksum="0980E999C72F1DFE" modified="2015-07-22" version="1">MNLLESVDAASLRDDIPPFRPGDTVNVHVRVIEGNRSRVQQFKGVVIRRQGAGVRESFTVRKVSFGVGVERTFPVHTPVVEKIELVTRGQVRRAKLYYLRDLRGKAAKIKEKRES</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NEM8</accession>
    <name>A0A0F7NEM8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Futalosine hydrolase</fullName>
            <shortName evidence="1">FL hydrolase</shortName>
            <ecNumber evidence="1">3.2.2.26</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Futalosine nucleosidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Menaquinone biosynthetic enzyme MqnB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">mqnB</name>
        <name evidence="4" type="ORF">AA958_13265</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the hydrolysis of futalosine (FL) to dehypoxanthine futalosine (DHFL) and hypoxanthine, a step in the biosynthesis of menaquinone (MK, vitamin K2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>futalosine + H2O = dehypoxanthine futalosine + hypoxanthine</text>
            <dbReference type="Rhea" id="RHEA:25904"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:58863"/>
            <dbReference type="ChEBI" id="CHEBI:58864"/>
            <dbReference type="EC" id="3.2.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Quinol/quinone metabolism; menaquinone biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PNP/UDP phosphorylase family. Futalosine hydrolase subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.26" evidence="1"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020019.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_13265"/>
    <dbReference type="EnsemblBacteria" id="AKH86736">
        <property type="protein sequence ID" value="AKH86736"/>
        <property type="gene ID" value="AA958_13265"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_13265"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2791"/>
    <dbReference type="OrthoDB" id="1860206at2"/>
    <dbReference type="UniPathway" id="UPA00079"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016799">
        <property type="term" value="F:hydrolase activity, hydrolyzing N-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00991">
        <property type="entry name" value="MqnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019963">
        <property type="entry name" value="FL_hydrolase_MqnB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03664">
        <property type="entry name" value="fut_nucase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNP_UDP_1" evidence="3">
        <location>
            <begin position="24"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="220"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH86736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="253" mass="24397" checksum="E22CB2008FBA20DD" modified="2015-07-22" version="1">MLVVVAVAAEAEAVERGGRGYDVVIGGVGPAAAAAGAAGALAAAPVPYDLVIAAGIGGGFAGVAPVGGVVVADEIVAADLGAETPDGFVSVTELGFGAVAHRPPPAAARAAAEAAGAVLGTVLTVSTVTGSAGRAAELRRRHPRAAAEAMEGFGVAEAATRHGVPVLEIRAVSNAVGPRDRAAWRIPEALNALTAAFAALPAFGELPDVAAVPDLAARPDLAEGGAPAADVAPADPAAGPAAHPARPDGEEPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-08-12" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NEP7</accession>
    <name>A0A0F7NEP7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_26515</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018430.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH85192">
        <property type="protein sequence ID" value="AKH85192"/>
        <property type="gene ID" value="AA958_26515"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_26515"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5580"/>
    <dbReference type="OrthoDB" id="1268974at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003313">
        <property type="entry name" value="AraC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037923">
        <property type="entry name" value="HTH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02311">
        <property type="entry name" value="AraC_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51215">
        <property type="entry name" value="SSF51215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="3">
        <location>
            <begin position="183"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH85192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="283" mass="30133" checksum="403400ECB97E9402" modified="2015-07-22" version="1">MGSRTARASGDADREWARHWRCTSLPGLDLLRARYVGHTFPTHSHDGYVFGAVTAGVEAVGMPDGTLLAGPGTVVMINPEVPHTARAGAAEGWSYATLYPTSGLVAEVAAEVTAIGGTAGFGETMVDDPGGARLITEVHRAAEEDNPLAADSVLRVVLARLLRRHGARLPGRVVASAGARTAARARAVLYERMAAPPTLEALAAELGTSPFALLRAFKEAYGTPPHRWLTDARVRRARRLLDEGLRPSEAAVTVGFTDQPHLNRHFTRIVGVPPGAYQRERAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFF7</accession>
    <name>A0A0F7NFF7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_33460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020655.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH87210">
        <property type="protein sequence ID" value="AKH87210"/>
        <property type="gene ID" value="AA958_33460"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_33460"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.7067"/>
    <dbReference type="OrthoDB" id="1009891at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038750">
        <property type="entry name" value="YczE/YyaS-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40078">
        <property type="entry name" value="PTHR40078"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH87210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="201" mass="20983" checksum="3C4009734B0D9FF5" modified="2015-07-22" version="1">MMVRAGIGLDPWDTFHQGLGKQTGWTMGVATIVVGAAVLLLWIPIRQRPGLGTVSNVVVIGVAMDASFALLPDVHGLALQIPQMLGGVVLNGVATGLYISARYGPGPRDGLMTGLHRRTGLSVRLVRTLIEITVLASGWVLGGAVGAGTVVYALAIGPLAQYFLRVFAIPEPASAGPGEVLRGGARRDTREVNYVPPGAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFU8</accession>
    <name>A0A0F7NFU8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_28960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH85607">
        <property type="protein sequence ID" value="AKH85607"/>
        <property type="gene ID" value="AA958_28960"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_28960"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="330" mass="34485" checksum="734064BFA569896D" modified="2015-07-22" version="1">MAVAAARWLPPRGSHRFEPSQSAYACIRQYQLESEARCNGFFPVRWVSARTTLWSKSVLYAQMVRPLVTCLTFGRIFSHGRAPATCSSVMPCTQYAPGVIEASGLTSVSSSVLPVAASMTAISTVCPSRSVVSVSRITAAPGCSRARASRVMPPHHGHRVISPAYGAVSGPAASSACTWARVGVASSWRSQSSSQPPEYGAVPGPHRDAVPVGQGLREALDAFGAGGGERGVLPQRRAGALAQTPYGLPVDAGHLPHRADVGEPEQRHRDGTPAGGTHGHLVGGGGLDPASRLDVLPVGRVADLQHVGGRGRGDVLLAVRLGRPAGRRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NGV7</accession>
    <name>A0A0F7NGV7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Exoglucanase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AA958_10445</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019937.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_10445"/>
    <dbReference type="EnsemblBacteria" id="AKH86669">
        <property type="protein sequence ID" value="AKH86669"/>
        <property type="gene ID" value="AA958_10445"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_10445"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2201"/>
    <dbReference type="OrthoDB" id="191946at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.870.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008965">
        <property type="entry name" value="CBM2/CBM3_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001956">
        <property type="entry name" value="CBM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036966">
        <property type="entry name" value="CBM3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023309">
        <property type="entry name" value="Endo-1-4-beta-glucanase_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027390">
        <property type="entry name" value="Endoglucanase_F_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000556">
        <property type="entry name" value="Glyco_hydro_48F"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00942">
        <property type="entry name" value="CBM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02011">
        <property type="entry name" value="Glyco_hydro_48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00844">
        <property type="entry name" value="GLHYDRLASE48"/>
    </dbReference>
    <dbReference type="SMART" id="SM01067">
        <property type="entry name" value="CBM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49384">
        <property type="entry name" value="SSF49384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51172">
        <property type="entry name" value="CBM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519636" evidence="7">
        <location>
            <begin position="31"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="8">
        <location>
            <begin position="691"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="domain" description="CBM3" evidence="9">
        <location>
            <begin position="778"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="128"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="131"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AKH86669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="930" mass="98497" checksum="3CA8F0D4C5BF3A2B" modified="2015-07-22" version="1">MSRRSFTTAAGGALVALGAGQALAGATAHAAEAPADDRTKAVAATPYTDAFLAQYEKIKDPGNGYFSPDGIPYHCVETLIVEAPDHGHQTTSEAFSFWIWLEAAYGRVTGDWGPFNGAWETAERSIIPPHVDQPSSGSYNPGSPATYAPEHSEVSSYPSQLDPDVPVGQDPIAAELASAYGTMDVYGMHWLMDLDNVYGYGNTPGTGGQNGPGPGASFINSYQRGSQESVWETIPQPTTDLFEFGGPNGYLDLFVGDASYAQQWKYTNAPDADARAVQAAYWALTWARAQGNESQVAESVARAAKMGDYLRYAMFDKYFKQIGDCDSPTGCPAGTGRTSQHYLLSWYYAWGGSTGSGGGWAWRIGDGASHQGYQNPFAAWALATVPELTPKSPTAKSDWATSLTRQLEFLRWLQSTEGALAGGCTNSWEGQYGTPPDGTPTFYGMPYDWQPVYHDPPSNNWFGFQVWGMERVAQYYHATGNADAGAVLAKWVAWASAETTVGADGSYRFPSTLRWTGAPDTWNAANPGANAGLHVEVVDYADDVGVGAALVMTLVYYAARAADTDAAALAKALLDAMAAHADDKGIAVPETRRDYDRFDDEVYVPAGWSGTSPYGDAIEPGVTFIGLRPWYREDPDWEKVQTYLDGGAAPVFTYHRFWAQAALALAFAAYGELLGGETPGGPGDDTEPPTVPGGLRITGTTASSVALAWTASTDNVRVTAYDVYRDGTPVGSATSTSFTDTGLSAATAYSYTVTARDAAGNASQPSAAVTATTGTGTGTGAVKVEYRNNDQALTDNQIRPGLRIVNTGGGALSLSTLTVRYWFSGESGAATYSTWCDYAQIGAANVTHRVVAAGGGKAGATHYLEVGFTAGAGSLAAGASTGDIQLRLNKTDWSAFDESDDYSRATTGTYIDAPRIVAYVAGSPVWGTEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NGX1</accession>
    <name>A0A0F7NGX1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_11160</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019954.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86684">
        <property type="protein sequence ID" value="AKH86684"/>
        <property type="gene ID" value="AA958_11160"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_11160"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2352"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519639" evidence="3">
        <location>
            <begin position="25"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH86684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="260" mass="23972" checksum="8B86A8F13D0AF798" modified="2015-07-22" version="1">MARIAASALIAGGASLAAAGAAQATGDDGGDNGRQGNGLEVSAIAGVAGIGDTDSGGDVAGPGGVDDGGTTDDGGTTDDGGTTDDGGTTDDGGTTDDGGTTDDGGTTDDGGTTDDGGTTDDGGTTDDGGTTDDGGTTDDGGTTDDGGTTDDGGTTDGGADDGGSGDDGGQQTTGGQQTTGGTGGGDTDCELDGDSVICEAESTSGGSEPSPAGDSEPQEQLADTGSSGTTYLLVGAASIIAGGVGFRLLPRLMTRNESAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NH11</accession>
    <name>A0A0F7NH11_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_12645</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aromatic prenyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_12645"/>
    <dbReference type="EnsemblBacteria" id="AKH86724">
        <property type="protein sequence ID" value="AKH86724"/>
        <property type="gene ID" value="AA958_12645"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_12645"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2657"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033964">
        <property type="entry name" value="Aro_prenylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020965">
        <property type="entry name" value="Prenyltransferase_CloQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036239">
        <property type="entry name" value="PrenylTrfase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11468">
        <property type="entry name" value="PTase_Orf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00036">
        <property type="entry name" value="Aromatic_Prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01163">
        <property type="entry name" value="II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143492">
        <property type="entry name" value="SSF143492"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH86724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="270" mass="29346" checksum="AEB2004612831326" modified="2015-07-22" version="1">MTALLTAFPNVVTDSTVVFNAVNKGGSIRDLSFDFTVPLAEGNPYERALEHGLAEETDHPVRGMFADLLTALPVDCYGVDYGVNSGFNKSYAVFPMGRLQELGPLASVPAMSTALSRWMDVLVEYGLDGKVSTVAIDHANRTWNVYFNGLSPEHFERATVQAMLRDFGLPEPSGQLLDFAATSSALYPTFGWDAAEIERVSFSTRTTDPAALPSHVEPKLGVLAAKAPYSYEGDRKLVFAGALTADGEYFKLATYYQLATAAHDRVRRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NH93</accession>
    <name>A0A0F7NH93_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AA958_32055</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019315.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_32055"/>
    <dbReference type="EnsemblBacteria" id="AKH86087">
        <property type="protein sequence ID" value="AKH86087"/>
        <property type="gene ID" value="AA958_32055"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_32055"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6768"/>
    <dbReference type="OrthoDB" id="760677at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="8"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="123"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="236"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH86087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="380" mass="41436" checksum="2170C7D101945C60" modified="2015-07-22" version="1">MKRRLYGPEHLAFRETVRTFLAKEVTPHYARWEADGIVSRDAWRAAGRQGLLGLAVPEEYGGGGHDDYRFAAVLAEEFAGAGAPGLAVGLHNDVIGPYLTSLATDEQKRRWLPGFCTGELITAIAMTEPGAGSDLQGIRTTAEDRGDHWLLNGAKTFISNGILADLVVVVARTTPEGGAHGLSLLVVERGAAGFERGRNLDKIGQKAQDTAELFFTDVRVPKDNLLGERDGAFGHLMAHLPQERMAIAVAAVAAAEHLVEATTAYVREREAFGRPLGRFQHIRFEIAEMATECAVTRTFVDRCIEDLAAGELDAVHASMAKWWATELQKRTADRCLQLHGGYGYMSEFPVARAFTDGRVQTIYGGTTEIMKEIIGRSLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NHD6</accession>
    <name>A0A0F7NHD6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cobalt transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AA958_17195</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="AKH86839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_17195"/>
    <dbReference type="EnsemblBacteria" id="AKH86839">
        <property type="protein sequence ID" value="AKH86839"/>
        <property type="gene ID" value="AA958_17195"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_17195"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3616"/>
    <dbReference type="OrthoDB" id="381612at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070161">
        <property type="term" value="C:anchoring junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="C:cytoplasmic vesicle"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:cation transmembrane transporter activity"/>
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        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cation_efflux"/>
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    </dbReference>
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        <property type="entry name" value="Tmem163"/>
    </dbReference>
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        <property type="entry name" value="PTHR31937"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0965">Cell junction</keyword>
    <keyword evidence="9" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
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    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="160"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004608"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AKH86839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="235" mass="23411" checksum="A329B41BB6B788C1" modified="2015-07-22" version="1">MAAGVGTGPGQSRAALLTRRIRLLVAATIAYNVVEAVVALTAGALASSAALIGFGLDSVVEVSSAAALAWQFSAVDPAARQAREGRTLRIIAVSFFALAAYVAVDALRALAGGAEAEPSVPGIVLAALSLAIMPFLSAAQRRAGRELGSASAVADSKQTLLCTYLSAVLLLGLVLNATAGWTFADPVAALVISAVAVREGRNAWRGEACCAVPGTTTASTTAACDCCGTHGGGPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NHR2</accession>
    <name>A0A0F7NHR2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DNA helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_23360</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="444103.AA958_23360"/>
    <dbReference type="EnsemblBacteria" id="AKH86984">
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        <property type="gene ID" value="AA958_23360"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:RNA helicase activity"/>
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        <property type="project" value="UniProt"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 3 7" id="KW-0347">Helicase</keyword>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="211"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="379"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="379"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH86984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="481" mass="51891" checksum="04473C2F2B402D20" modified="2015-07-22" version="1">MALAGTDVIGQAKTGTGKTLGFGLPLLEKVVVPADVENGRADTGALTDAPQALVVVPTRELCVQVTNDLLTAGKVRNVRALSIYGGRAYEPQLEALKKGVDVVVGTPGRLLDLAGQRKLDLSKIKVLVLDEADEMLDLGFLPDVEKIIQQLPAKRQTMLFSATMPGQVIGLARRYMSQPTHIRATAPDDEGATVAAVEQHAFRAHSMDKPEMLARILQAEGRGLTMIFCRTKRTCADVAEQLTRRGFAAGSVHGDLGQGAREQALRAFRNGKVDVLVCTDVAARGIDVAGITHVINYQTPEDEKTYLHRIGRTARAGASGTAVTFVDWDEITRWHLINKALELDLENPEETYSTSPHFFEALRIPEGTKGVLPRAERTRAGLGAEELEDLGETGGGRRGAGSRRSATEERPKRTRTQRQRRRTRSGRPVAAEAAEGAAGQQETAPEQTVSAGADAADAAPRKPRRRRRRTRSGNAGTPAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NI06</accession>
    <name>A0A0F7NI06_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_33890</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86397">
        <property type="protein sequence ID" value="AKH86397"/>
        <property type="gene ID" value="AA958_33890"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_33890"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.7156"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="10"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="HTH cro/C1-type" evidence="5">
        <location>
            <begin position="11"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH86397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="355" mass="38019" checksum="F39B394E0441EDB6" modified="2015-07-22" version="1">MSVKRRRGAPTQADVARRAGVSQATVSAVVNGRATDHRIPVETEELVRQAVRDLGYAANPAARSLKGKRNRMIGVHTFESVFPIASRDFYHEFLVGVEEQAVAEGHDLVLFTSTEGPDGQRQLYSDGSNRLNVADGSVLLGVAHDHSDLARLSREGYPFVHIGRRDVPGADIAWVSADYAEATRDAVARLVSLGHRRVGYLGITHRVEAVVDREAGYRTACADAGIPQLPVLMNAGDLTQEWFDLALASGMTAFVAEDESFAGRIAGFAAARDLAIPARLSLVVLRGTETGPYPGTGWSCVEIPRREIGREAVRLLLRLLDTPDAPREDQILLSCTPPGGETVAVAPAGAPGGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NI68</accession>
    <name>A0A0F7NI68_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_22210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_22210"/>
    <dbReference type="EnsemblBacteria" id="AKH86963">
        <property type="protein sequence ID" value="AKH86963"/>
        <property type="gene ID" value="AA958_22210"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_22210"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4677"/>
    <dbReference type="OrthoDB" id="1818284at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="136" mass="13501" checksum="6F1C9054399D6D71" modified="2015-07-22" version="1">MAGAALLAEAVALAVVHFVLGSVVDRQDMSLAGLDSGLMSASTRAAGVAIGLYLLCCGAVALRIAVRDRAPGRAGRILLVSCAVLHAVLAAVAVGLVGWAAFAGLMVLFGLIVLTLTAEDVPVRQAEGGAEPAPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NIB7</accession>
    <name>A0A0F7NIB7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_02430</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_02430"/>
    <dbReference type="EnsemblBacteria" id="AKH86507">
        <property type="protein sequence ID" value="AKH86507"/>
        <property type="gene ID" value="AA958_02430"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_02430"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.520"/>
    <dbReference type="OrthoDB" id="1191583at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015424">
        <property type="term" value="F:ABC-type amino acid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030679">
        <property type="entry name" value="ABC_ATPase_HisP-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039085">
        <property type="entry name" value="ABC_ATPase_HisP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="15"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="47"/>
            <end position="54"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH86507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="263" mass="28420" checksum="17D311048AB22146" modified="2015-07-22" version="1">MDKTGDTAAQGAPAISVEGLHKSFGDLEVLGGIDLTVARGEVVCVIGPSGSGKSTLLRCVNMLEEPSAGRITVAGAEVTDPDVDIDRVRRRIGMVFQSFNLFPHLTVLDNLTIAQRRVLGRSRPEAQEVARANLVRVGLTEKEASYPAQLSGGQQQRVAIARALSMEPELMLFDEPTSALDPELVGDVLAVMRHLADEGMTMLVVTHEMSFAREVADRVVFMDEGTIVEQGVPEQVIGKPQHRRTRTFLARVLDPAAAEVAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NK68</accession>
    <name>A0A0F7NK68_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_32535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_32535"/>
    <dbReference type="EnsemblBacteria" id="AKH87197">
        <property type="protein sequence ID" value="AKH87197"/>
        <property type="gene ID" value="AA958_32535"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_32535"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6867"/>
    <dbReference type="OrthoDB" id="1744037at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023187">
        <property type="entry name" value="Tscrpt_reg_MarR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01117">
        <property type="entry name" value="HTH_MARR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="30"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH87197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="173" mass="19283" checksum="6AE4B0AF000E9996" modified="2015-07-22" version="1">MEENSAAPLDHVARIQAEWARERPDLDVTPQAVIGRLHRLGALLTRRLCLVYDQYGLSEGEFDVLAALRRAGDPYERAPGELAAHTMVTTGAMTKRIDRLERNGLVTRRRSASDGRGRVVALTSAGRKLIDRAFTDHMRNERGLLDAVSPEEAAQLRTLLTTWLARLEQLDGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MXV7</accession>
    <name>A0A0F7MXV7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycerol kinase</fullName>
            <ecNumber evidence="5">2.7.1.30</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ATP:glycerol 3-phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Glycerokinase</fullName>
            <shortName evidence="5">GK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">glpK</name>
        <name evidence="9" type="ORF">AA958_01635</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + glycerol = ADP + H(+) + sn-glycerol 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:21644"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.30"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="5">Inhibited by fructose 1,6-bisphosphate (FBP).</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the FGGY kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.30" evidence="5"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014444.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_01635"/>
    <dbReference type="EnsemblBacteria" id="AKH81080">
        <property type="protein sequence ID" value="AKH81080"/>
        <property type="gene ID" value="AA958_01635"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_01635"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.359"/>
    <dbReference type="OrthoDB" id="233605at2"/>
    <dbReference type="UniPathway" id="UPA00618">
        <property type="reaction ID" value="UER00672"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004370">
        <property type="term" value="F:glycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006072">
        <property type="term" value="P:glycerol-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00186">
        <property type="entry name" value="Glycerol_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018483">
        <property type="entry name" value="Carb_kinase_FGGY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005999">
        <property type="entry name" value="Glycerol_kin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01311">
        <property type="entry name" value="glycerol_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00445">
        <property type="entry name" value="FGGY_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="5 6 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FGGY_N" evidence="7">
        <location>
            <begin position="5"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="FGGY_C" evidence="8">
        <location>
            <begin position="261"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="83"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="245"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="13"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="412"/>
            <end position="416"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH81080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="506" mass="54836" checksum="7772EB4336367766" modified="2015-07-22" version="1">MTDKYVAAIDQGTTSSRCIVFDQNGAIVAVDQREHRQIFPRPGWVEHDATEIWAKTQAVVAGALAKAGLRADELSAVGITNQRETTVLWDRATGKPVHNAIVWQDTRTAALCTELGGEDGQDRFRDRTGLPLASYFSGPKAAWLLDNVPGLRRRAENGEIAFGTVDSWLIYNLTGGVDGGVHVTDVTNASRTMLMNIETHQWDESILSAMDLPAAMLPEIRSSAEIYGTCTGQLGGVPVASALGDQQAAIFGQTCYGVGEAKNTYGTGSFLLLNTGTRPVPSKSGLLTTMGYQIGGEAPVYCLEGSIAITGALVQWFRDQLGIISAAEEIETLAASVDDNGGAYIVPAFSGLFAPYWRGDARGVVTGLTRYVTKAHLARAVLEATSWQTREVVDAMYEDSGVRLTDLKVDGGMTANNLLMQHQADVLGVPVMRPVISETTCLGAAYAAGLATGVWRDQDELRSHWKRDTEWTPHMDEGTREREYRNWRKAVERSFGWQDDQEAGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MYR4</accession>
    <name>A0A0F7MYR4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pyridoxal 5'-phosphate synthase subunit PdxS</fullName>
            <shortName evidence="3">PLP synthase subunit PdxS</shortName>
            <ecNumber evidence="3">4.3.3.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Pdx1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pdxS</name>
        <name evidence="7" type="ORF">AA958_03315</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = H(+) + 3 H2O + L-glutamate + phosphate + pyridoxal 5'-phosphate</text>
            <dbReference type="Rhea" id="RHEA:31507"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
            <dbReference type="EC" id="4.3.3.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; pyridoxal 5'-phosphate biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">In the presence of PdxT, forms a dodecamer of heterodimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the PdxS/SNZ family.</text>
    </comment>
    <dbReference type="EC" id="4.3.3.6" evidence="3"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014729.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_03315"/>
    <dbReference type="EnsemblBacteria" id="AKH81370">
        <property type="protein sequence ID" value="AKH81370"/>
        <property type="gene ID" value="AA958_03315"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_03315"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.705"/>
    <dbReference type="OrthoDB" id="784095at2"/>
    <dbReference type="UniPathway" id="UPA00245"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036381">
        <property type="term" value="F:pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042823">
        <property type="term" value="P:pyridoxal phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04727">
        <property type="entry name" value="pdxS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01824">
        <property type="entry name" value="PdxS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001852">
        <property type="entry name" value="PdxS/SNZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033755">
        <property type="entry name" value="PdxS/SNZ_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31829">
        <property type="entry name" value="PTHR31829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01680">
        <property type="entry name" value="SOR_SNZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029271">
        <property type="entry name" value="Pdx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00343">
        <property type="entry name" value="TIGR00343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01235">
        <property type="entry name" value="PDXS_SNZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51129">
        <property type="entry name" value="PDXS_SNZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0704">Schiff base</keyword>
    <feature type="domain" description="SOR_SNZ" evidence="6">
        <location>
            <begin position="19"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="D-ribose 5-phosphate binding" evidence="3">
        <location>
            <begin position="247"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with D-ribose 5-phosphate" evidence="3">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH81370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="306" mass="32180" checksum="9D1A790376255A61" modified="2015-07-22" version="1">MSSTPRSAPQSSAPETGTARVKRGMAEQLKGGVIMDVVTPEQAKIAEDAGAVAVMALERVPADIRKDGGVARMSDPDMIEGIIEAVSIPVMAKSRIGHFVEAQILQALGVDYIDESEVLTPADEVNHSDKWAFTTPFVCGATNLGEALRRIAEGAAMIRSKGEAGTGNVVEAVRHLRQIKNEIGALRGLDSHELYAAAKELRAPYEVVAEVAKLGKLPVVLFSAGGVATPADAALMRQLGAEGVFVGSGIFKSGDPAKRAAAIVKATTFYDDPKVVADASRNLGEAMVGINLDTLDDAERYAGRGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MYY3</accession>
    <name>A0A0F7MYY3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sphingosine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_03940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014837.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_03940"/>
    <dbReference type="EnsemblBacteria" id="AKH81480">
        <property type="protein sequence ID" value="AKH81480"/>
        <property type="gene ID" value="AA958_03940"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_03940"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.827"/>
    <dbReference type="OrthoDB" id="869726at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045540">
        <property type="entry name" value="YegS/DAGK_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19279">
        <property type="entry name" value="YegS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00046">
        <property type="entry name" value="DAGKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="SSF111331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAGKc" evidence="1">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="296" mass="30409" checksum="AC15815CE4DB8766" modified="2015-07-22" version="1">MTSDITVFVNPTAGRGRGAKAAPVVTEALRDAGYEVATVQGSDAATALAGAREAVAAGTGALISVGGDGMAALALQAVAGTEVPVGIVAVGTGNDFARATGLPVRDPAAAAEVVVGALESGSTRAIDLGMAGDTYFGTVLASGFDSRVNDRGNRMSWPPGRFKYDVAMVAELASFRPIPYRMRLDDGPETEIEATLVAVGNGPSYGGGMRICHEARMDDGLFDITVVGRCSRRTLLRVFPRVYKGTHLTHPAVTVHRAARVSLSAADVTGYADGEPLGPLPLTAECVPGAARVLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MZ29</accession>
    <name>A0A0F7MZ29_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_01010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH80981.1"/>
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        <property type="protein sequence ID" value="AKH80981"/>
        <property type="gene ID" value="AA958_01010"/>
    </dbReference>
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    <dbReference type="PATRIC" id="fig|444103.5.peg.223"/>
    <dbReference type="OrthoDB" id="1775418at2"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
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        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SSF64288"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HTH_GNTR"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="11"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH80981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="245" mass="26173" checksum="172B0F2D90C685AF" modified="2015-07-22" version="1">MGTTQPDTVTELKYWHLKGVISEALESEFSVGEILPNERELAARFGVARATLRQALDQLELEGRLQRRRGVGTTVAPPRVGVPVGSPREMWPGEADDGWEAVDASAVAAPAAVARMLGTDATEPVHRVHRSRSRNGQPVAAELIYVPGDSAPGFSRGDSSAGAARARAVLHELHRLPLEGQDRTVELGSARAEDARELDRLPGAPVLVVTTRYVSRGRTAAVAVSTYRADTCRLTLDADAAVLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MZ82</accession>
    <name>A0A0F7MZ82_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_04640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_04640"/>
    <dbReference type="EnsemblBacteria" id="AKH81600">
        <property type="protein sequence ID" value="AKH81600"/>
        <property type="gene ID" value="AA958_04640"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_04640"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.978"/>
    <dbReference type="OrthoDB" id="1860081at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
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        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="13"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="125" mass="12936" checksum="4CDA018669587183" modified="2015-07-22" version="1">MTIQIIVDQQAPEAPYEQVRAQISAQARGGVLPAGTKLPTVRGLAEQLGLAPNTVAKAYRALESDGVIETRGRHGSYVAAAGDAAQREAAAAAQVYAQRAQRLGLDHGTALTAVEEALRAAYAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MZB7</accession>
    <name>A0A0F7MZB7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_04805</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
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            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the band 7/mec-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014980.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH81625">
        <property type="protein sequence ID" value="AKH81625"/>
        <property type="gene ID" value="AA958_04805"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_04805"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1012"/>
    <dbReference type="OrthoDB" id="1213601at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043202">
        <property type="entry name" value="Band-7_stomatin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001972">
        <property type="entry name" value="Stomatin_HflK_HflKC_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264">
        <property type="entry name" value="PTHR10264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00721">
        <property type="entry name" value="STOMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="SSF117892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PHB" evidence="3">
        <location>
            <begin position="22"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="256"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH81625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="330" mass="35329" checksum="7E24496B328345FA" modified="2015-07-22" version="1">MIEALIAAAVTIVCLGAIYLMAGARVVKQYERGLVFRLGRLRPGLRGPGFVMIVPFVDRMRKVSMQIVTLPIPAQEGITRDNVTVRVDAVVYFKVVAPADAVIQVEDYRFAVSQMAQTSLRSIIGKSELDDLLSNREKLNQGLELMIDSPAVEWGVTIDRVEIKDVSLPETMKRSMARQAEAARDRRARVINADAELQASRKLAQAAEQMADHPSALQLRLLQTVGAVAAEKNSTLVLPFPVELLRFLERAQSGLAGPGPAGAPAAGGPPAAADGAGAGAEEGENDDVPAPLDPIDPLGMVEKRELGSPGDAATAEELEPPQQDGEDRED</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MZN5</accession>
    <name>A0A0F7MZN5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_02130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014530.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_02130"/>
    <dbReference type="EnsemblBacteria" id="AKH81166">
        <property type="protein sequence ID" value="AKH81166"/>
        <property type="gene ID" value="AA958_02130"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_02130"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.458"/>
    <dbReference type="OrthoDB" id="302683at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011048">
        <property type="entry name" value="Haem_d1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019405">
        <property type="entry name" value="Lactonase_7-beta_prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10282">
        <property type="entry name" value="Lactonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51004">
        <property type="entry name" value="SSF51004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH81166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="348" mass="35579" checksum="F78221CE2E67F696" modified="2015-07-22" version="1">MGESVLRACVGSFSSRGGAGITVADIDPGTGALTPRHSTDAVADPSFLAVADGGLLYAVSQTEGGSVAAFRLADDKPEPAGDPVPVSGDHPAHLALAGGHVLTANYTSGSFSTVTVNRDGTLAGPAALLQHEGSGPVTERQEGPHAHQVVPDPTGRWVLGVDLGTDSVLVCALDADRGALRLNHEVPLRPGTGPRHLAFHPEGHRVYVACELEPVVTVCSWDAATGTLEPLAEAPMLTDETAAVDETPYASGIAVSPDGRFCWTAVRGPDVVATLALGDDGGVRGLVSNVPCGGTWPRDLAIDPGGRHLYAANEHSGDVTWFDIDSESGTPRRSGSAALPAASCVVFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0B5</accession>
    <name>A0A0F7N0B5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_07305</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015415.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_07305"/>
    <dbReference type="EnsemblBacteria" id="AKH82065">
        <property type="protein sequence ID" value="AKH82065"/>
        <property type="gene ID" value="AA958_07305"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_07305"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1530"/>
    <dbReference type="OrthoDB" id="1074175at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="97"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="166"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="220"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="263"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="98"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH82065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="301" mass="32815" checksum="24BE8A073E65A9F4" modified="2015-07-22" version="1">MAHTKEGPAATAAAPARAEAKDPAPRRGYDAEKLFNRVALGVLVAFALLWLVPLLFATAISIRPADEIAVDPASWFTSNPTFAAYEDLFDKGKLPYWYANSFIVSLLTTVLTVVTASLAAFGLSQVRFRFRRGVFLLLLAGIMIPMQVLMIPQFLALQEVGLLNTYWGVVLPQVPNVVAVFVFKQFFDGIPRELIEAARADGAGWLRTYGQIVMPVSRPAVSAVTIFVFVAVWNNFLWPLLVVTDPEMMTLPVGLNSVQDAFGIPYAQLMASAVLGAIPLLVVFALFQRRIVEGIAGTGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0I0</accession>
    <name>A0A0F7N0I0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH luxR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_00610</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH80913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_00610"/>
    <dbReference type="EnsemblBacteria" id="AKH80913">
        <property type="protein sequence ID" value="AKH80913"/>
        <property type="gene ID" value="AA958_00610"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_00610"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.142"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="797"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="436"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH80913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="863" mass="94174" checksum="A5FB81F57616C450" modified="2015-07-22" version="1">MGATILSVQGRSTAAHPPISLFQQLVAQVPAPPPGEGPAGATPALQFSAALPHVAENGAVVISIDDVQDIPWSELDFLLQAVGWHRSRRTLVLLSHCPHLRHRDQPVKTELLRRPNAQRIHLGPLDERGVRAAVTTRVNRPHEQWIELLHHLSGGSPLLLRALLEDLRDEDMEARPTGAESAAELGMYGRAVVSCLYRSGATAVELGRLISVLGDSAAPELLSGMTRISPAVMDQQLEALRHSGLLDGTNFRHESAPREILADLGTLQRNELHRRAAVVQNNAGSPTTEVARHLLAARHAAEAWQRSALRDAAETAIGQENIRLAVRYLELALENSPSGPDRIEIYMRLALITQRISPAATEIRHLTALLSAFHADKMPSTAYDGLADLLFSYGKVQEAFAVLQRQGAESSAADVRAGDHPSIAWLWAWYSHHSSGQEDAGQDGRDAEQEGGAQNARLPPADGGARSPYASATSLFQTFEGTFLFGGRGDWAAAAENLLEVSTLSDATVWSLASSIKALVIADRLDAAWQWCEWLVKESASRDAPGWQAIFSLQQAIVALRQGKLAAGLDCVRLVESVITERSTGYACAAEAVLAALHMEMGRYDEVARVFAKPIPPAWEKSVYWLSYLCIRGCFHLSTNRPHSALADFLRIGKVAERTLVDHPTLVPWRLYVAQAWLHLGDQQMSARMLAEHTARAPGHGGRDHAMVLRLRARLAPPHKRPGLLFRAMDELLATGDRLDQARTLHELGVALHGLGHESWAARAQAAGAHIARNCLPDQAVARTPVPERTSKAVHDTLGKERLLTRAEHRVAALVAKGLTNRQVANRLHITVSTVEQHLTRIYQKLGISQRADIGTRLKSIPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N147</accession>
    <name>A0A0F7N147_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MDMPI_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_01710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014458.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_01710"/>
    <dbReference type="EnsemblBacteria" id="AKH81094">
        <property type="protein sequence ID" value="AKH81094"/>
        <property type="gene ID" value="AA958_01710"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_01710"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.374"/>
    <dbReference type="OrthoDB" id="1548598at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017517">
        <property type="entry name" value="CHP03083_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024344">
        <property type="entry name" value="MDMPI_metal-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036527">
        <property type="entry name" value="SCP2_sterol-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11716">
        <property type="entry name" value="MDMPI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55718">
        <property type="entry name" value="SSF55718"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03083">
        <property type="entry name" value="TIGR03083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MDMPI_N" evidence="1">
        <location>
            <begin position="20"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="242" mass="26340" checksum="DA5FF482802A11C6" modified="2015-07-22" version="1">MAEAGGLLRGPEVWAYVLDGHERLRISLAELTEGRERESSRLPGWTRAHVLSHIEGICRAQTRQARYALKGELIEVYDGGRPARDAGIEAGAVRSAAELTAAVTATLAEAEAVWGSVGDADWDRPVRYRDGDLLGALYCWWRELEVHTADAKLETCSAAWPRELCLHLFDFLAPRVPAGLTLVESDGPVRHTFGARGAGGGDDSAGRAPVVRGRLTDLASWLAGREPHHRLDGRLPDLGPWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N187</accession>
    <name>A0A0F7N187_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Electron transfer flavoprotein subunit alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_02010</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The electron transfer flavoprotein serves as a specific electron acceptor for other dehydrogenases. It transfers the electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ETF alpha-subunit/FixB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014508.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_02010"/>
    <dbReference type="EnsemblBacteria" id="AKH81144">
        <property type="protein sequence ID" value="AKH81144"/>
        <property type="gene ID" value="AA958_02010"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_02010"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.434"/>
    <dbReference type="OrthoDB" id="1400253at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01715">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001308">
        <property type="entry name" value="ETF_a/FixB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033947">
        <property type="entry name" value="ETF_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014731">
        <property type="entry name" value="ETF_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018206">
        <property type="entry name" value="ETF_asu_C_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43153">
        <property type="entry name" value="PTHR43153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00766">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000089">
        <property type="entry name" value="Electra_flavoP_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00696">
        <property type="entry name" value="ETF_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ETF" evidence="7">
        <location>
            <begin position="4"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH81144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="331" mass="33803" checksum="89D4BDE051FA1658" modified="2015-07-22" version="1">MTEVLVYVDHVDGAVRKPTLELLTLARRIGDPVAVHLGPGVDAAAPVLAEHGAVRVLTADAAEFADYLVVPKVDALKAAYDAVQPAAVLLPSSVECKEIGARLAVRIGSGIITDAVDVEAGDGGSTAQGEASGGGPVTTQAVFAAAFTTRSRVSRGTPVITVKPNSAAPEAAPVESAVEQLTFGFGESAAGTKVVGRTPRESTGRPDLTEAAIVVSGGRGVNGAENFRIIEELADSLGAAVGASRAAVDAGWYPHSHQVGQTGKTVSPQLYIAAGISGAIQHRAGMQTSKTIVAVNKDNEAPIFDLVDYGVVGDLFAVVPQLTEEVKARKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N1J3</accession>
    <name>A0A0F7N1J3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_03030</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014681.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH81318">
        <property type="protein sequence ID" value="AKH81318"/>
        <property type="gene ID" value="AA958_03030"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_03030"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.646"/>
    <dbReference type="OrthoDB" id="626204at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="255"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="317"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="344"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="379"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="407"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="1"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="209"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH81318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="432" mass="43246" checksum="4B76F951437C23C5" modified="2015-07-22" version="1">MTADARRTDRALGAPAPVPGGPPGGSRRWMWLAAWPVVAALALSNEPAPLYVLWQGRFGFSAATITLVYAAYIAGLLVTLTFAGTLADRYGRRPVLLPGLALSLTATVLFATAESVAVLGVARLLSGFAVGAVLAAGMAAVADLAPPGQKQFGGLVASASMVGGAALGPMLAGVLAETLPHPTRLVFVVQTGLLLVALAVVLRMPLSRPGERRGERPGGGAEAGTGDGSAADSAARRARRLVRIPSVPRPHRRTLLLSLAVLAPGMTATGFVLSLGPALLADLLDSDNRALAGGMIFLLFAAATGVQFAVRTLRVRVLFILGAVLTTAGMAALVLATAVTSVPLLLAAAVLAGLGQGSAQLGGLSTLSARIPATRLAEANAALTGGGYLMAGVLPVAAGYLSDAVGLTAGTTAFGIAVAVLVTAGAVAATRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N1J7</accession>
    <name>A0A0F7N1J7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Valine--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Valyl-tRNA synthetase</fullName>
            <shortName evidence="8">ValRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">valS</name>
        <name evidence="13" type="ORF">AA958_09635</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-valine + tRNA(Val) = AMP + diphosphate + L-valyl-tRNA(Val)</text>
            <dbReference type="Rhea" id="RHEA:10704"/>
            <dbReference type="Rhea" id="RHEA-COMP:9672"/>
            <dbReference type="Rhea" id="RHEA-COMP:9708"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78537"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.9"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">The C-terminal coiled-coil domain is crucial for aminoacylation activity.</text>
    </comment>
    <comment type="domain">
        <text evidence="8">ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.9" evidence="8"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015789.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_09635"/>
    <dbReference type="EnsemblBacteria" id="AKH82445">
        <property type="protein sequence ID" value="AKH82445"/>
        <property type="gene ID" value="AA958_09635"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_09635"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2030"/>
    <dbReference type="OrthoDB" id="32262at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004832">
        <property type="term" value="F:valine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006438">
        <property type="term" value="P:valyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07962">
        <property type="entry name" value="Anticodon_Ia_Val"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02004">
        <property type="entry name" value="Val_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033705">
        <property type="entry name" value="Anticodon_Ia_Val"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037118">
        <property type="entry name" value="Val-tRNA_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019499">
        <property type="entry name" value="Val-tRNA_synth_tRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002303">
        <property type="entry name" value="Valyl-tRNA_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946">
        <property type="entry name" value="PTHR11946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10458">
        <property type="entry name" value="Val_tRNA-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00986">
        <property type="entry name" value="TRNASYNTHVAL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="SSF46589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="SSF50677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00422">
        <property type="entry name" value="valS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1" evidence="10">
        <location>
            <begin position="27"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_1" evidence="11">
        <location>
            <begin position="611"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="domain" description="Val_tRNA-synt_C" evidence="12">
        <location>
            <begin position="805"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="8">
        <location>
            <begin position="55"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="8">
        <location>
            <begin position="529"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="532"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF10458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AKH82445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="872" mass="96901" checksum="37ADC7A9420AC3E5" modified="2015-07-22" version="1">MTDAKNPQSSAAELPTQYTPGEVETSLYEGWVERGYFAADAKSDKPPYAIVIPPPNVTGSLHLGHAFEHTLIDALTRRKRMQGYETLWQPGMDHAGIATQNVVERELAKEGLSRHDLGREAFVERVWKWKAESGGQIAGQMRRLGDGVDWSRDRFTMDEGLSRAVQTIFKRLFDDELIYRAERIINWCPRCLTAISDIEVEYQDDDGELVSIRYGEGEQSIVVATTRAETMLGDTAVAVHPDDERYRHLVGTEIVLPLTGRRIPVLADEHVDPEFGTGAVKVTPAHDPNDFEIGRRHDLPMLTIMDEHAVITAHGPFQGLDRLEARSAIVAALRADGRIVAEKRPYTHSVGHCSRCKTTIEPRLSLQWWVKVGPLAKAAGDAVRDGRVAIHPKEMESRYFGWVDHLNDWCISRQLWWGHRIPVWHGPDGELVCVGPDEEPPSGEGWTQDSDVLDTWFSSGLWPFSTLGWPEETESLAKFYPNSVMVTGYDILFFWVARMMMFGLYAMDGEIPFRTIALHGMVRDQFGKKMSKSFGNAVDPLEWMDKYGSDAVRFTLARGANPGTDVPIGEDWVQGSRNFANKVWNATRFALMNGATVEGPLPAEAELSTTDRWILSRLGAVVAEVDALYDDYQFAKLSDVLFHFAWDEVFDWYVELSKTTFAGGGPAADASRRVLGEVLDVTLRLLHPVVPFVTETLWTTLTGRESLVIADWPADSGFRDAAAEAEIVKLQEVVTEVRRFRADQGLQPGQRVPARVELSGAGLEEHEAAMRQLLRLQPEGGSFAATASLPVAGATVALDLSGTIDVAAERKRLTKDLAAAEKEKAQAEAKLGNEGFLAKAPEPVVAKIRTRLAKAEEDIVRIGAQLERLPQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N1Y7</accession>
    <name>A0A0F7N1Y7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Argininosuccinate lyase</fullName>
            <shortName evidence="5">ASAL</shortName>
            <ecNumber evidence="3 5">4.3.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Arginosuccinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">argH</name>
        <name evidence="8" type="ORF">AA958_03585</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>2-(N(omega)-L-arginino)succinate = fumarate + L-arginine</text>
            <dbReference type="Rhea" id="RHEA:24020"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57472"/>
            <dbReference type="EC" id="4.3.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.1" evidence="3 5"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014777.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_03585"/>
    <dbReference type="EnsemblBacteria" id="AKH81419">
        <property type="protein sequence ID" value="AKH81419"/>
        <property type="gene ID" value="AA958_03585"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_03585"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.755"/>
    <dbReference type="OrthoDB" id="751464at2"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00114"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004056">
        <property type="term" value="F:argininosuccinate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01359">
        <property type="entry name" value="Argininosuccinate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00006">
        <property type="entry name" value="Arg_succ_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029419">
        <property type="entry name" value="Arg_succ_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009049">
        <property type="entry name" value="Argininosuccinate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43814">
        <property type="entry name" value="PTHR43814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14698">
        <property type="entry name" value="ASL_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00838">
        <property type="entry name" value="argH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4 5" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lyase_1" evidence="6">
        <location>
            <begin position="26"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="ASL_C2" evidence="7">
        <location>
            <begin position="377"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH81419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="486" mass="51732" checksum="247404B770259FD2" modified="2015-07-22" version="1">MSDGTEGAAPQDVKLWGGRFADGPAAALERLSASVHFDMRLAPYDIAGSRAHARVLARAGLLTADELNRMLAGLDHLETDVATGVFTATIADEDVHTALERGLLERLGPELGGKLRAGRSRNDQVATLFRMYLRDHARTLGGLLAELQEALVGLAEAHPDVAMPGRTHLQHAQPVLFAHHVLAHAQALSRDAERLRQWDERTAVSPYGSGALAGSSLGLDPEAVAAELGFERGSSGNSIDGTAARDFAAEFAFVTAMIGVDVSRIAEEVILWATKEFSFVTLHDSFSTGSSIMPQKKNPDIAELARGKAGRLIGNLTGLMATLKALPLAYNRDLQEDKEPVFDSIDTLEVLLPAFTGMMATLTVNRERLEELAPAGFSLATDIAEWLVKQGVPFRVAHESAGECVKVCEAEGIELDQLTDEQFAKVSPHLTPEVRTVLTVPGALAARDARGGTAPAAVAVQLAEVKEDVAAQVRWAAATRQAGPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2A8</accession>
    <name>A0A0F7N2A8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Luciferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_04155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014874.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_04155"/>
    <dbReference type="EnsemblBacteria" id="AKH81519">
        <property type="protein sequence ID" value="AKH81519"/>
        <property type="gene ID" value="AA958_04155"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_04155"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.872"/>
    <dbReference type="OrthoDB" id="1434838at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019951">
        <property type="entry name" value="F420_OxRdatse_Rv3520c_pred"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03559">
        <property type="entry name" value="F420_Rv3520c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="17"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="349" mass="37190" checksum="C763B12C4EE65E39" modified="2015-07-22" version="1">MRLGINLGYWGAGMDADNLAVAQEADRLGYDVCWAAEAYGSDAATVLSWVAAKTERIDVGSAIFQIPARAPAMTAMTAATLDSLTEGRFRLGIGVSGPQVSEGWYGVEFGKPLARTREYVEIVRKALSRERLSYAGEHWTLPLPGGAGKPIKLTVHPVREHIPVYIAAIGPKNLEQTGEIAEGALLVFYSPEHAEETTLRHVRAGRAKAGKELDAFDIVPTVPMALGDDIAALADVFRPYTALYVGGMGSAKQNFYNRLAGRMGYEREAAEIQAAYLAGDKAGAAAAVPQELIDATTLLGPVERIADRMRAYAEAGVTSLSLAPSGFTREERIAGVRAGVEALERAGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2C3</accession>
    <name>A0A0F7N2C3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MFS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_04295</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014893.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH81538">
        <property type="protein sequence ID" value="AKH81538"/>
        <property type="gene ID" value="AA958_04295"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_04295"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.902"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
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            <end position="27"/>
        </location>
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            <end position="63"/>
        </location>
    </feature>
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        </location>
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        </location>
    </feature>
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            <end position="150"/>
        </location>
    </feature>
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            <begin position="156"/>
            <end position="180"/>
        </location>
    </feature>
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            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
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            <end position="254"/>
        </location>
    </feature>
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        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
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        <location>
            <begin position="355"/>
            <end position="374"/>
        </location>
    </feature>
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        <location>
            <begin position="4"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="380"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH81538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="402" mass="41156" checksum="E2B6364C20E1DD73" modified="2015-07-22" version="1">MKAKLLVLASGNFVVGVSTFVIAPLLGRIGADLDVSRTAAAQLVVVYALAYALGGPVLTALAGHRPPRQLLFVALAVFGAGNGLTAVAANFPGAVAARVLAGVGAGVYTANALAVARRLAPGDRQGRAVAVVVGGLTTALVLGLPLGAWLGGETGWRLVLGLLSLAAVLPMAAIRLLPAFGGSPAVPLAARVAPLRDRQVLATLLATWLCLTASWTVYNFIDQVLLEATGGDPDRLFPALLVFGAGAVAGNLLAGRLADRFGPDRTIAVVAPGLVVAVLVVPLAAVAMPPALLSIGAWAMLHWMVNVPQQIRVVATAPESAPVVLGLHQSTIYLGISAGGFVGSLGYGLAGRSGIGYAAFLTGLTALTALWWSFRMRHPSRPSPPPTPTHTQAPRQKKVRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2E4</accession>
    <name>A0A0F7N2E4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">XRE family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_07925</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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    </dbReference>
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    </dbReference>
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        <property type="gene ID" value="AA958_07925"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_07925"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1669"/>
    <dbReference type="OrthoDB" id="1292067at2"/>
    <dbReference type="Proteomes" id="UP000034283">
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="18"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="195" mass="21558" checksum="35043CF26B0BDA67" modified="2015-07-22" version="1">MDDQPSVGAVIDQIAPRLRRARETKGVSLATLARTTGISTSTLSRLESGRRKPSLELLLPVTAALGVPLDEIVAAPRIVDPRVRQQPTTRDGRVLIPLSRQQGEPRAYKMTIPAHDKEPHLRTHAGHEWLYVLRGRLRVRLAERDFVMTAGEAAEFDCRIPHWFGAAGRGPVDVLSLFGKSGERIHLRTGGGRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2N6</accession>
    <name>A0A0F7N2N6_9ACTN</name>
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        <submittedName>
            <fullName evidence="6">Penicillin-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_12130</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016195.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_12130"/>
    <dbReference type="EnsemblBacteria" id="AKH82860">
        <property type="protein sequence ID" value="AKH82860"/>
        <property type="gene ID" value="AA958_12130"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_12130"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2552"/>
    <dbReference type="OrthoDB" id="423699at2"/>
    <dbReference type="Proteomes" id="UP000034283">
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    </dbReference>
    <dbReference type="GO" id="GO:0016021">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
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        <property type="entry name" value="MecA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05223">
        <property type="entry name" value="MecA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519181" evidence="3">
        <location>
            <begin position="32"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="MecA_N" evidence="5">
        <location>
            <begin position="78"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="4">
        <location>
            <begin position="295"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH82860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="574" mass="59698" checksum="6588B4BE95F6E41A" modified="2015-07-22" version="1">MAGSHRRRRVGSGASARATRTRIAVVVGVGAAVVGAAGFGAYSLLEDDKVESGGNALSAPASSDPVKTGPPGPRETARAAGEFLAAWAGGDTETAAGMTDDRKAALRGLDAYREDAGVEKVKLTPGRPQGTEVPFSVDARVTFGDNVKPWAYNSALEVVRDEKTGEPEVAWDPSLIHPKLTEGERLRTGSTEAPPIRALDRTGARLDPEEYPSLAPVLADLRERYGAKAGVKVWTEPADAPRGDKKKDEKDDDKAGTPETLLVLSKAKPGTLQTTLDAAVQETAEEAVAKQGGAALVALQPSTGQILAVANQVPDGHNTALQGTLPPGSTMKVVTASMLMDKGLAAPDRPHPCPRYKAYGGWEFENVGDNSFTIQGGTFTQSFTASCNTAFISMAEKLENDDLTKQARDVFGIGLNWQTGVTTFDGSVPVQSGVEMALSLIGQGGVRMNPLTMASVSATAKSGVFKQPHLVPQGFDGRQFATAPKSMKASTAQSLRELMEETARTGTAAGAMSGLTGQVGAKTGSAEMGGQEETDAWFTAYRGDLAAAATVPNIGHGGEFAGPLVRDVLAAHGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2R0</accession>
    <name>A0A0F7N2R0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SURF1-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_05200</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SURF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015049.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_05200"/>
    <dbReference type="EnsemblBacteria" id="AKH81694">
        <property type="protein sequence ID" value="AKH81694"/>
        <property type="gene ID" value="AA958_05200"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_05200"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1092"/>
    <dbReference type="OrthoDB" id="1908280at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd06662">
        <property type="entry name" value="SURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002994">
        <property type="entry name" value="Surf1/Shy1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045214">
        <property type="entry name" value="Surf1/Surf4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23427">
        <property type="entry name" value="PTHR23427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02104">
        <property type="entry name" value="SURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50895">
        <property type="entry name" value="SURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="252"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH81694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="310" mass="33463" checksum="C5524D2C7B0F7C26" modified="2015-07-22" version="1">MYRFLLSRQWVIVTLVAVLLIPVMIQLGFWQFHRHEDRVARNDLVARNLKAEPVPVDRLMREGRTVPREDTWRTVTATGAYEPEREVVVRQRLGADDKQGYFVVTPLRLADGSAVLVNRGWVPAGADLTTFPEVPPPPAGEVTVTGRLRPDETTGSGIRDKAGLPDRQVMLINSADEAADGLPGPVLGGFVELVGTSPKAAGKQPEPVSEPDHSSIGVHIAYAIQWWIFAAAVPFGWWVLVRRERRDREAAAAKAAGEENAVPAEPAEDGEAPGGTPAGEAGKTADAPARRAADDDRAPSLAPAEQMAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N305</accession>
    <name>A0A0F7N305_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AA958_13175</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016357.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH83025">
        <property type="protein sequence ID" value="AKH83025"/>
        <property type="gene ID" value="AA958_13175"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_13175"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2773"/>
    <dbReference type="OrthoDB" id="1891092at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="83"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="128"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="10">
        <location>
            <begin position="34"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AKH83025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="285" mass="30681" checksum="7D37DA5524CD5226" modified="2015-07-22" version="1">MSTVTDTAAAEKRPRPSAREQAPGGAVKWAIADCWTVVRRGLLHYRRQPSNIAWQLGFPVVSVLLFVYVFGSAMEGGADAYKSYAMPGMFAMTMAFGFMNTAMLIAIDKEHGITDRFRSMPMSPSAVVSGRGVSDLIGAALDLAVMAAIALVIGWRSDGSVLETAAAFALLLWLRFALIWVGVVLGLLTPNQEAAGNLFAVAFPFGMVSSVFASPADMPGWLGAIAMWNPVSSTANAVRELFGNPGRLGDSWIEQHAMLMALVWPVVITAVFLPLAVRKYQRLSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N337</accession>
    <name>A0A0F7N337_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA polymerase-binding protein RbpA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rbpA</name>
        <name evidence="4" type="ORF">AA958_05675</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Binds to RNA polymerase (RNAP), stimulating transcription from principal, but not alternative sigma factor promoters.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2">Bind 1 Zn(2+) per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Forms a complex with the RNAP catalytic core and with free principal sigma factors.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNA polymerase-binding protein RbpA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_05675"/>
    <dbReference type="EnsemblBacteria" id="AKH81773">
        <property type="protein sequence ID" value="AKH81773"/>
        <property type="gene ID" value="AA958_05675"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_05675"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1188"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001000">
        <property type="term" value="F:bacterial-type RNA polymerase core enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01483">
        <property type="entry name" value="RbpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038638">
        <property type="entry name" value="RbpA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025182">
        <property type="entry name" value="RNApol-bd_RbpA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018527">
        <property type="entry name" value="Rubredoxin_Fe_BS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13397">
        <property type="entry name" value="RbpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00202">
        <property type="entry name" value="RUBREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH81773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="95" mass="10598" checksum="1759AD9FF0FFDF68" modified="2015-07-22" version="1">MGEAERGESAPRLRVSFWCSNGHETRPSFATDAQIPDSWDCPRCGFPAGQDRDNPPDPPRTEPYKTHLAYVRERRSDADGEAILAEALAKLRGEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N390</accession>
    <name>A0A0F7N390_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_13745</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016449.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH83120">
        <property type="protein sequence ID" value="AKH83120"/>
        <property type="gene ID" value="AA958_13745"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_13745"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2894"/>
    <dbReference type="OrthoDB" id="1570162at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004111">
        <property type="entry name" value="Repressor_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02909">
        <property type="entry name" value="TetR_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="43"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH83120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="268" mass="28562" checksum="4393ED0819BB0F58" modified="2015-07-22" version="1">MDAMDAAGEGRRGEDKRDAGAVPASVEAAWGLRPRPQKGPKRGLTLDGIVAAAVAVADAEGLEAASMGRVAKELGVSTMALYRYVATKDELVTLMVDGAFGPPPPLPAEAEGDWRAGLRHWYQAVGKAMFAHPWAVAHVPSGGPPVTPNQLAALDQALYILRDTPLTEFEKVATALLVSNQVRAEVTIALAMGGSPDVERLMNEYSRFLLRVSDAGHLPHLRTAVEGGAFDEGDAEAPQNPSDYDEFAFGLERVLDGIEALINGRRRD</sequence>
</entry>
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    <accession>A0A0F7N3G9</accession>
    <name>A0A0F7N3G9_9ACTN</name>
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        <submittedName>
            <fullName evidence="2">Septum formation initiator</fullName>
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    <gene>
        <name evidence="2" type="ORF">AA958_06565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
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            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015281.1">
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_06565"/>
    <dbReference type="EnsemblBacteria" id="AKH81929">
        <property type="protein sequence ID" value="AKH81929"/>
        <property type="gene ID" value="AA958_06565"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_06565"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1370"/>
    <dbReference type="OrthoDB" id="2001190at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="197" mass="19874" checksum="C3F0A2A538C4B2E9" modified="2015-07-22" version="1">MKRPRIAFPREGGARLLGGSSAARTPFVLLVVLLLGAGLLALLLLNAAVNQGSFRVGNLKKETTRLTDEEQRLRQEVEEQSAPDALEKRARELGMVPGGPPVFLSPVGGVRGEPWTATGPPPPAPSPAAAAKPSPEDGDARARAAEKAEAPGKAGQGAADEAGQAEGAPAEPPASPAPGTSASPSAAAPRPAAQEAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3R3</accession>
    <name>A0A0F7N3R3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_14910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016610.1">
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_14910"/>
    <dbReference type="EnsemblBacteria" id="AKH83295">
        <property type="protein sequence ID" value="AKH83295"/>
        <property type="gene ID" value="AA958_14910"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_14910"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3142"/>
    <dbReference type="OrthoDB" id="1744037at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="144" mass="16044" checksum="A4E106918109470F" modified="2015-07-22" version="1">MPVDGAQLWTLNQRLLGVVMDACTRELAELGLETKEFFVLAEVEASPYPAEIATALLLPKASVTVYVRNLVAKGFVRREIDEADLRRHRLVLTAEGTQARDRARAALAAEYDRRLAMVTPQDRVELQRILKAMLAAPASGRTRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3S7</accession>
    <name>A0A0F7N3S7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_04090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_04090"/>
    <dbReference type="EnsemblBacteria" id="AKH81507">
        <property type="protein sequence ID" value="AKH81507"/>
        <property type="gene ID" value="AA958_04090"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_04090"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.859"/>
    <dbReference type="OrthoDB" id="1979322at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
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    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="1">
        <location>
            <begin position="4"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="275" mass="30464" checksum="98B1199827657C7F" modified="2015-07-22" version="1">MPRIDAHHHLWDISRRPQPWMDGSWADPLRRTFTLADLAPHLAEHRIDATVLVQSSSSYEETLELCEEPDPPVALVCGWLDLTAPGLDADTLRRTPPRLGAVRHQAEEEPDPRWLERPDVLRALGLVGEAGLVYDLLVTERELPAAIAAARAVPHTRFVLDHAGKPQIAAGEWQPWADLVAGLARLPNVSCKLSGLVTQADWEHWRPADVLPYARHVIDVFGPGRILFGSDWPVCTLAADYGRVVELAEEAVADLTAAEREAFFGGNARRLYLGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3T9</accession>
    <name>A0A0F7N3T9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_07040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018837591.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_07040"/>
    <dbReference type="EnsemblBacteria" id="AKH82013">
        <property type="protein sequence ID" value="AKH82013"/>
        <property type="gene ID" value="AA958_07040"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_07040"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1474"/>
    <dbReference type="OrthoDB" id="1522794at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025445">
        <property type="entry name" value="DUF4191"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13829">
        <property type="entry name" value="DUF4191"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH82013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="231" mass="24412" checksum="9D25FBECDF0EEF78" modified="2015-07-22" version="1">MASSEPTPENTGRLKQIALTYKMTRRADPKVGLIVAGVGILVLGAALGIGFLIGHPIYLGIVGFLLALLGMAIVFGRRAEAAAFGQMEGQPGAAAAVLDNMKRGWTVTPAVSMTRQQDVVHRAVGKAGIVLVGEGNPNRLKGLLAAEKKKMNRVVADVPVHDIVVGNDEGQVPLKKLRATLVKLPRVLQGPQVTQVNDRLKALGDLMSNMPIPKGPMPKGMRMPKGGGKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3U1</accession>
    <name>A0A0F7N3U1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_15085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016635.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_15085"/>
    <dbReference type="EnsemblBacteria" id="AKH83320">
        <property type="protein sequence ID" value="AKH83320"/>
        <property type="gene ID" value="AA958_15085"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_15085"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3178"/>
    <dbReference type="OrthoDB" id="1271038at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="264" mass="27756" checksum="471E73DAD8CFDAE4" modified="2015-07-22" version="1">MNATQHHDAGHGQHGAHGHHGHHAPAGPAGLDSSEDGYTLALETTAAPAGAETELRFRLLGNDGRPVTGLTPIHDKLVHLIVVRRDLTRYVHVHPAEAADGTWSVRVLLPEAGAYRVFADFAPAALGRTLTLGADLTAGDGAGPAHELPAPAPAFTVDGREVTLTGELAAGEGRRLEFAVARDGEPVTDLQPYLAAYGHLVAVRREDLAYVHVHPDGSPGDGTTGPGPVVAFHAQVPGPGTYRLFLDFKHEDAVRTAEFTAVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3W3</accession>
    <name>A0A0F7N3W3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chemotaxis protein CheY</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_11280</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_027773850.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_11280"/>
    <dbReference type="EnsemblBacteria" id="AKH82716">
        <property type="protein sequence ID" value="AKH82716"/>
        <property type="gene ID" value="AA958_11280"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_11280"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2377"/>
    <dbReference type="OrthoDB" id="930905at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="24"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="169"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH82716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="239" mass="26449" checksum="7B384093F74DAB46" modified="2015-07-22" version="1">MAEFELSGAGEPKATVGPREEPIRVLVVDDHELFRRGLEIVLAQEEDIQVVGEAGDGAEAVDKAADLLPDIVLMDIRMPRRSGIEACTAIKEVAPSAKIIMLTISDEEADLYDAIKAGATGYLLKEISTDEVSTAIRAVADGQSQISPSMASKLLTEFKSMIQRTDERRLVPAPRLTDRELEVLKLVATGMNNRDIAKELFISENTVKNHVRNILEKLQLHSRMEAVVYAMREKILEIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3X2</accession>
    <name>A0A0F7N3X2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_04415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014912.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_04415"/>
    <dbReference type="EnsemblBacteria" id="AKH81557">
        <property type="protein sequence ID" value="AKH81557"/>
        <property type="gene ID" value="AA958_04415"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_04415"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.930"/>
    <dbReference type="OrthoDB" id="867226at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="3"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="475" mass="51196" checksum="3BAB359D8B4893C4" modified="2015-07-22" version="1">MSDVIIAGGGPTGLMLAAELRLHGVRVVVLEKEREPTKVVRALGLHARSIEVLDQRGLLEKFLALGTRYPVGGFFAGIAKPAPDRLDSAHAYVLGLLQTLTDRLLEEHAAEAGAEIRRGREVTGLSQDGDGVTVEVAGSEPLRARYLVGCDGGRSTVRKLLGVGFPGEPSRVDTLLGEMELTASPETVTAVMAEVRRTQLRFGLMPLPDGAYRVGVPAAGVAEDRSVPPAFDEFRAQLRAVAGTDFGVHSPRWLSRFGDATRLAERYRVGRVLLAGDAAHVHPPVGGQGLNLGVQDAFNLGWKLAAALAGWAPEGLLESYHAERHPVAAGVLDFTRAQMELMSTEPGPQAVRRLMADLMDFGEVHRYLIERVMAIGIRYDFGPGHELLGRRLRDMPLSEGRLYELTRAGRGLLLDRTGRLSVAGWADRVDHVVDAAAELDVPAVLLRPDGHVAWAGEDQAGLLDHLPRWFGAPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4A3</accession>
    <name>A0A0F7N4A3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_16085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016784.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_16085"/>
    <dbReference type="EnsemblBacteria" id="AKH83475">
        <property type="protein sequence ID" value="AKH83475"/>
        <property type="gene ID" value="AA958_16085"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_16085"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3390"/>
    <dbReference type="OrthoDB" id="2029543at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="101" mass="10616" checksum="284B044D23803454" modified="2015-07-22" version="1">MPQAVQPPQRNIGLFASDGEYHVAQDTLLAITLAVGAIALVLAQWRGLHVPATWAGLIGIVTGAWGQMISVTTRERFLILLGLGASGLGFFLAMARGGFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4T4</accession>
    <name>A0A0F7N4T4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F420-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_17240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016969.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_17240"/>
    <dbReference type="EnsemblBacteria" id="AKH83665">
        <property type="protein sequence ID" value="AKH83665"/>
        <property type="gene ID" value="AA958_17240"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_17240"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3625"/>
    <dbReference type="OrthoDB" id="1434838at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019921">
        <property type="entry name" value="Lucif-like_OxRdtase_Rv2161c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03619">
        <property type="entry name" value="F420_Rv2161c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="300" mass="32678" checksum="4720F38AEE995093" modified="2015-07-22" version="1">MKIGFALPQFHRQAFDIARTATFASAIEEAGGASLWVGDRNLAAVRPVVGYGGRGTTIPEELNPAADPFVLLGVAAASTSRVLLGSHVLIAPLYPPVQLARSLTTIDLISGGRLLPGFGIGWSPEEYRAAGLDFTRRGARMDELLDVLDAIWTTDPARYEGDQLSVPEHHSPLKPARQPRPPFYLGALSERALRRVARRGDGWLPLMVVPSYVDVDGLLAQRSFLDELARQDGRDPRAIDTVLRVNIDAGTSTAKVVDTVKDIHERTGIDHFMIDSMYEIGTVEGSVEHARRILELVGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4X3</accession>
    <name>A0A0F7N4X3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glutamate 5-kinase</fullName>
            <ecNumber evidence="8">2.7.2.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Gamma-glutamyl kinase</fullName>
            <shortName evidence="8">GK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">proB</name>
        <name evidence="10" type="ORF">AA958_09515</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + L-glutamate = ADP + L-glutamyl 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:14877"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58274"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the glutamate 5-kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.11" evidence="8"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_09515"/>
    <dbReference type="EnsemblBacteria" id="AKH82424">
        <property type="protein sequence ID" value="AKH82424"/>
        <property type="gene ID" value="AA958_09515"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_09515"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2006"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00359"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004349">
        <property type="term" value="F:glutamate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04242">
        <property type="entry name" value="AAK_G5K_ProB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00456">
        <property type="entry name" value="ProB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041739">
        <property type="entry name" value="G5K_ProB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001057">
        <property type="entry name" value="Glu/AcGlu_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011529">
        <property type="entry name" value="Glu_5kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005715">
        <property type="entry name" value="Glu_5kinase/COase_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019797">
        <property type="entry name" value="Glutamate_5-kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01472">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000729">
        <property type="entry name" value="GK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00474">
        <property type="entry name" value="GLU5KINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01027">
        <property type="entry name" value="proB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00902">
        <property type="entry name" value="GLUTAMATE_5_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 8" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PUA" evidence="9">
        <location>
            <begin position="264"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="2"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="159"/>
            <end position="160"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="201"/>
            <end position="207"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AKH82424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="357" mass="37513" checksum="B7B86FE878AA5AEB" modified="2015-07-22" version="1">MKVGSSSLTTAAGGLDADRVDALVDALAKHGDREIVLVSSGAIAAGLAPLGLGKRPRDLARQQAAASVGQGLLMARYTASYARYARRVGQVLLTTDDMSRRTHYRNAQRTLEQLLAMGAVPVVNENDTVATEEIRFGDNDRLAALVAHLARADLLVLLSDVDGLYDGPPGAPGASRIAEVRHRGELAGVRLGTAGRAGVGTGGMVTKVEAARIATGEGVPVVLTSAVHADAALAGQPTGTYFHPTGRRARGRLLWLAHASTPLGALVLDDGAVRAVTERRTSLLPAGIKEVEGRFTAGDPVELRDTSGRAVARGLVAFDAEELPRLLGRSTRELAKELGPAYEREVVHRDDLVVLDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5E2</accession>
    <name>A0A0F7N5E2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC transporter ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_14495</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_14495"/>
    <dbReference type="EnsemblBacteria" id="AKH83241">
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        <property type="gene ID" value="AA958_14495"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_14495"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3052"/>
    <dbReference type="OrthoDB" id="1347467at2"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025723">
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    </dbReference>
    <dbReference type="InterPro" id="IPR016300">
        <property type="entry name" value="ATPase_ArsA/GET3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10803">
        <property type="entry name" value="PTHR10803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02374">
        <property type="entry name" value="ArsA_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ArsA_ATPase" evidence="2">
        <location>
            <begin position="20"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH83241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="408" mass="43109" checksum="3208706E341E1674" modified="2015-07-22" version="1">MSLDTAPRLDADGLLDDPQTRIVVCCGAGGVGKTTTAAALGVRAAERGRRVVVLTIDPAKRLAQSMGIDALDNSPRRVDGVEGPGELYAMMLDMKRTFDEIVEAHADGDRANAILENPFYQSLSAGFAGTQEYMAMEKLGQLRARDSWDLIIVDTPPSRSALDFLDAPKRLGSFLDGRFIRLLTAPAKAGGRAGMKFLNVGMSMMTGTLGKLLGASLLRDVQTFVAAMDTLFGGFRTRAEATYRLLQAPGTAFLVVATPERDALREAAYFVERLEADRMPLAGLVLNRVHESDAAQLSAERALAAAETLDERGVDDAGSGAKGAGAADTGAGTGGTGTEGAADAAALLRLHAERMQVLAHERRTRDRFAALHPEVPVTQVTALPGDVHDLAGLRDVAELLTAQEAPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5F0</accession>
    <name>A0A0F7N5F0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-lactamase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_10715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015959.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_10715"/>
    <dbReference type="EnsemblBacteria" id="AKH82618">
        <property type="protein sequence ID" value="AKH82618"/>
        <property type="gene ID" value="AA958_10715"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_10715"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2254"/>
    <dbReference type="OrthoDB" id="1712770at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="18"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="250" mass="26948" checksum="7EA0C3DAF45FE3D7" modified="2015-07-22" version="1">MKLTVVGCSGSFPSADSACSSYLVEAEGYALLLDMGNGALGALQQHCGLYDLDAVLLSHLHADHCIDMCAYFVARYYRHDGGPAEVLPVYGPKGTEQRLTTAYADTPSETSMSEVFDFRALERGAFEIGPFRVHADRVSHPVEAYAFRIEHDDRSLVYSGDTGPCEALTELSADADLLLCEAAFTHGREQIPDLHLNGREAGEAAAAAGVGRLVLTHIPPWTDPQVNLRDAKDMYGGPVELARAGAVYEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5H0</accession>
    <name>A0A0F7N5H0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_07265</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015407.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_07265"/>
    <dbReference type="EnsemblBacteria" id="AKH82057">
        <property type="protein sequence ID" value="AKH82057"/>
        <property type="gene ID" value="AA958_07265"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_07265"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1522"/>
    <dbReference type="OrthoDB" id="460405at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010290">
        <property type="entry name" value="TM_effector"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05977">
        <property type="entry name" value="MFS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="260"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="294"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="23"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="419"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH82057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="446" mass="46817" checksum="3FFD95EAFC3AD250" modified="2015-07-22" version="1">MADESRAYRDLLPDLAPWHASRDFRLMWVAGLITAFGSFLTFVALPVQVKELTGSALAVGAIGTVELVPLIVFGLYGGALADAMDKRKLILYSEAGLGLVSAVLLLNSLLPEPMLWPLYVVAALTSALTGIQRPALDSIVPRIVPHEHLPAAAALNSLRWQLGGIAGPALAGFIVAYAGLPWAYALDAGTFAVSVGLALMLAPSPAAREAVAPSLRAIAEGARYAWNRKELLGTYAIDLAAMFFAFPLALFPFLADDLDAPWALGLMYAALPAGSLLVSLTSGWTRRVHRHGRAVMLSAVGWGLAITAAGMMPNAWAVLLLLMVAGAFDMVSGVFRAAMWNQTIPDELRGRLAGIELLSYSVGPVAGQFRSGGVAALTSVRTSIWSGGVMCAGAVVLLAACLPKLMTYDARTNEHAVRERDRRAAAAAEKAGKGGPEGVPAPDPAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5T8</accession>
    <name>A0A0F7N5T8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_07985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015532.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH82182">
        <property type="protein sequence ID" value="AKH82182"/>
        <property type="gene ID" value="AA958_07985"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_07985"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1684"/>
    <dbReference type="OrthoDB" id="964689at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="323" mass="34710" checksum="6A45E7DE0B89D549" modified="2015-07-22" version="1">METKRWAGPVLAVALAAVAIGWGTVSHSGDGEAGGDTVDSAVRDQAPDRSRFTPPDPATPGPGASGSAPADPGAPPRAPQDVLYLGDSLAMEAQDILGSRLERSARVGSYSSEPVAGVTVCDYLQGRPGRSLVPDEDKAAALVRKREPGVIVLQFWGNTWGYTPCMEGVEWGTPAYYERYAEDLRALTGQITDAAREADVPRPRIVWVQQPPDALHPDRIEQVNDLYERQSAASGDLLADGGRELRDGDGKWTQYLPCNDYEQRTAGFCTGPGGTARLHRDDDPLHFCLAPTPEGGRPCPAKSPGLERYTRAIEDEVDAYLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N607</accession>
    <name>A0A0F7N607_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">50S ribosomal protein L9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rplI</name>
        <name evidence="9" type="ORF">AA958_16065</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the bacterial ribosomal protein bL9 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_027741613.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_16065"/>
    <dbReference type="EnsemblBacteria" id="AKH83471">
        <property type="protein sequence ID" value="AKH83471"/>
        <property type="gene ID" value="AA958_16065"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_16065"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3385"/>
    <dbReference type="OrthoDB" id="1959318at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.430.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00503">
        <property type="entry name" value="Ribosomal_L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000244">
        <property type="entry name" value="Ribosomal_L9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009027">
        <property type="entry name" value="Ribosomal_L9/RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020594">
        <property type="entry name" value="Ribosomal_L9_bac/chp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020069">
        <property type="entry name" value="Ribosomal_L9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036791">
        <property type="entry name" value="Ribosomal_L9_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020070">
        <property type="entry name" value="Ribosomal_L9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036935">
        <property type="entry name" value="Ribosomal_L9_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21368">
        <property type="entry name" value="PTHR21368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03948">
        <property type="entry name" value="Ribosomal_L9_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01281">
        <property type="entry name" value="Ribosomal_L9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55653">
        <property type="entry name" value="SSF55653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55658">
        <property type="entry name" value="SSF55658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00158">
        <property type="entry name" value="L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00651">
        <property type="entry name" value="RIBOSOMAL_L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 7" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="RIBOSOMAL_L9" evidence="8">
        <location>
            <begin position="13"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH83471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="148" mass="15600" checksum="63D2A705D6256EAC" modified="2015-07-22" version="1">MKIILKGEVSGLGAAGDVVEVKDGYARNYLIPNGLAIRWTRGGEKDVAQIRRGRKLREIASVEQANAVKSELEGVQVRLSTRAGASGRLFGAVTPADIATAIKQAGGPDVDKRRIELSAPIKSLGAHQVSVRLHPEVDAKVGVEVVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N625</accession>
    <name>A0A0F7N625_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosomal RNA small subunit methyltransferase G</fullName>
            <ecNumber evidence="2">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">16S rRNA 7-methylguanosine methyltransferase</fullName>
            <shortName evidence="2">16S rRNA m7G methyltransferase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rsmG</name>
        <name evidence="3" type="ORF">AA958_16180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Specifically methylates the N7 position of a guanine in 16S rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016799.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_16180"/>
    <dbReference type="EnsemblBacteria" id="AKH83491">
        <property type="protein sequence ID" value="AKH83491"/>
        <property type="gene ID" value="AA958_16180"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_16180"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3409"/>
    <dbReference type="OrthoDB" id="1590629at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070043">
        <property type="term" value="F:rRNA (guanine-N7-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00074">
        <property type="entry name" value="16SrRNA_methyltr_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003682">
        <property type="entry name" value="rRNA_ssu_MeTfrase_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31760">
        <property type="entry name" value="PTHR31760"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02527">
        <property type="entry name" value="GidB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00138">
        <property type="entry name" value="rsmG_gidB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="2">
        <location>
            <begin position="127"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH83491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="242" mass="25638" checksum="6D55C6AC944C011D" modified="2015-07-22" version="1">MSEVADLPPAPEAADKVFGGALPDAVRYAELLADTAVTRGLIGPREVPRLWERHLLNCAVLAEVVPDGVAVCDVGSGAGLPGIPLALVRPDLRITLLEPLLRRTRFLQEVTELLGLEQQVTVVRGRAEEVLGTLEPVHVVTARAVAPLDRLAGWGVPLLRPYGEMLALKGESAEEELRASKAALHKLGVTETEIVQVGADVVDPPATVVRAVVGESPGGVRFAAKRARAARKGGRGGHGRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N632</accession>
    <name>A0A0F7N632_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_08600</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Membrane</location>
            <topology evidence="1 5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015630.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_08600"/>
    <dbReference type="EnsemblBacteria" id="AKH82282">
        <property type="protein sequence ID" value="AKH82282"/>
        <property type="gene ID" value="AA958_08600"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_08600"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1814"/>
    <dbReference type="OrthoDB" id="751256at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008271">
        <property type="term" value="F:secondary active sulfate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="PTHR11814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="245"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="352"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="409"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="7">
        <location>
            <begin position="471"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="286"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="286"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH82282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="602" mass="61849" checksum="1B4D20E93E46FEC5" modified="2015-07-22" version="1">MNAFLLRVWRPVRTLLPARADLGDMGREPRRDLLAGLTVAIVALPLALGFGVSSGLGAEAGLATAVVAGAVAAFFGGSSLQVSGPTGAMTVVLVPIVAQYGPGGVLAVGLLAGVMLVGLAVARAGRYMRYVPAPVVEGFTLGIACVIALQQMPNALGVEKPEGERVLVVTWRALEEFAAAPNWTAVALTAAVVTIMLAGARWRPTVPFSVVAVIAATLAAQAFHLTDAKPIGELPAGLPAPSLGFLDVGDLGTLLAPAVAVAALAALESLLSAQVADGMATAQASHAAQTGQASQTSQKAKAAPAPQHHDPDKELFGQGLANIAAPLFGGVPATGAIARTAVNVRTGARSRLASLTHAAVLAVIVFAAAPLVSKIPLAALAGVLLATAVRMVEVASLRAMARATRSDAAVLVLTAGATLALDLVYAVIIGLLVAGALALRDVARQARLDQVSFKAHLPGDHTDEEHSLLAEHIVKYRLEGPLFFAGAHRFLLELTDIADVRVVILRMSRVSTIDATGALVLKDAVETLDRRGIVVLTSGIRPEHRRALDSVGALDLLRAEGREYATTPGAVAAARRHLHGAGILPAPHPDPRAATLVEEPNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N649</accession>
    <name>A0A0F7N649_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-oxoisovalerate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_16460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016841.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_16460"/>
    <dbReference type="EnsemblBacteria" id="AKH83536">
        <property type="protein sequence ID" value="AKH83536"/>
        <property type="gene ID" value="AA958_16460"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_16460"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3464"/>
    <dbReference type="OrthoDB" id="900125at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transket_pyr" evidence="1">
        <location>
            <begin position="16"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="345" mass="36900" checksum="DAF10B3F61C0A7BF" modified="2015-07-22" version="1">MTTTAVAGTAAGRKPATMAQALTRAMRDAMAADPAVHVMGEDVGQLGGVFRITQGLAEEFGEDRCADTPLAEAGILGTAVGMAMYGLRPVVEMQFDAFGYPAFEQLVSHVSRMRNRTRGATPMPLTIRVPYGGGIGGVEHHGDSSEAYYMATPGLHVVTPGTVADAYGLLRAAIASDDPVVFMEPKRLYWSKAAWDPDRPEEVPGIGRAVVRRPGTTATLVTYGPSVPVCLEAAEAAREEGWDLEVVDLRSLVPFDEETVTASVRRTGRAVVVHESPGFAGPGGEIAARIGERCFHYLEAPVLRVAGLDIPYPPPMLEKHHLPGVDRVLDAVSRLQWEAEWTEGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N668</accession>
    <name>A0A0F7N668_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_16660</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_16660"/>
    <dbReference type="EnsemblBacteria" id="AKH83571">
        <property type="protein sequence ID" value="AKH83571"/>
        <property type="gene ID" value="AA958_16660"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_16660"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3506"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="14"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="134"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="134"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH83571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="238" mass="25587" checksum="6F6E3F781728121D" modified="2015-07-22" version="1">MDTPAIPGQRHGHVLLLADPDEQVAHDLAEHLAGHQVKVVFCSDGAEALLQVGLQSPDALLVSAKLPLVPGARVVEVLRRRSTTPVIIGVGPDDAEDAVEALTAGASACVARPYRPYEVLKMLGVASPATYDVDQTVASGPYSVNPATFEARVDGRLVQLPLREFKLLHLLVANAEKVVTRDQISAELWGGSAPKSNTIAVHIRRLRDRIGDNPHDPRIILTVRNVGYRFVPPAPDLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N685</accession>
    <name>A0A0F7N685_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">4-diphosphocytidyl-2-C-methyl-D-erythritol kinase</fullName>
            <shortName evidence="8">CMK</shortName>
            <ecNumber evidence="2 8">2.7.1.148</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ispE</name>
        <name evidence="11" type="ORF">AA958_12100</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>4-CDP-2-C-methyl-D-erythritol + ATP = 4-CDP-2-C-methyl-D-erythritol 2-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57823"/>
            <dbReference type="ChEBI" id="CHEBI:57919"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.148"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 3/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the GHMP kinase family. IspE subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.148" evidence="2 8"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016189.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_12100"/>
    <dbReference type="EnsemblBacteria" id="AKH82854">
        <property type="protein sequence ID" value="AKH82854"/>
        <property type="gene ID" value="AA958_12100"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_12100"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2546"/>
    <dbReference type="OrthoDB" id="1938933at2"/>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00094"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050515">
        <property type="term" value="F:4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00061">
        <property type="entry name" value="IspE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004424">
        <property type="entry name" value="IspE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010376">
        <property type="entry name" value="IspE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="SSF55060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00154">
        <property type="entry name" value="ispE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="5 8 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP_kinases_N" evidence="9">
        <location>
            <begin position="105"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP_kinases_C" evidence="10">
        <location>
            <begin position="223"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="28"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="113"/>
            <end position="123"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AKH82854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="321" mass="31615" checksum="8E0A03720658BB55" modified="2015-07-22" version="1">MTSGSTTPAPGPAPAAAARSVTVRVPAKVNVQLAVGPPRADGFHDLANVFLAVGLYDEVTATEADALRVTVTGPDAAAVPTDTSNLAARAAQLLAARHGREPNVHLHIAKDIPVAGGMAGGSADGAGALLACDALWGTRTGTDELLRICAELGSDVPFSLVGGAALGRGRGERLTTLSAKGPLYWVFAVADGGLSTPEVYGEFDRLVAGRSVPDPDPSPAVLDALGSGDPADLAAALTAIAGGNDLQPAALSLRPSLAETLEAGTAAGALAALVSGSGPTCAFLAADETAAVEVAAALEASGTCRKARVAQAPAPGAVVVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-10-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6G8</accession>
    <name>A0A0F7N6G8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_09270</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015733.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH82387">
        <property type="protein sequence ID" value="AKH82387"/>
        <property type="gene ID" value="AA958_09270"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_09270"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1956"/>
    <dbReference type="OrthoDB" id="1439189at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="290"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH82387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="317" mass="33901" checksum="5AF4AB483C3B20DF" modified="2015-07-22" version="1">MDAHVRDLRYFAAVAEELSFTRAAERLYVSQPALSKQIRALERQLGFPLFERRARTIALTPQGAALLPAVRELTAGWAEAVRAARTAGPAESLAVGMQTAVGRDLQREVLGRFRERGWRISLRLVNWEDPTAGLAGGGADAAFCWLPVPGVGAELTAKVLAREERWVALPLDHRFAGRTAVDFADLLDEPFVALPRSAGVLRDFWLGTAERGGREPVVALEASAPEEVFEAVGAGLGVVLLAEGNARLYPRPDVVSVPVRGLAPCELALLWRTADGRREVAEFAAAFREAPAPAGGGGGSGPGRRDSGAQGSTREHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6T1</accession>
    <name>A0A0F7N6T1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Small membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_13425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016395.1">
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_13425"/>
    <dbReference type="EnsemblBacteria" id="AKH83064">
        <property type="protein sequence ID" value="AKH83064"/>
        <property type="gene ID" value="AA958_13425"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_13425"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2823"/>
    <dbReference type="OrthoDB" id="1864842at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519262" evidence="1">
        <location>
            <begin position="35"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="137" mass="14361" checksum="5B3C90958ADB4656" modified="2015-07-22" version="1">MKQAARRIGRTIAFVLPVVLVLSGTLAVATVPWASPSTDARMLSASAESATARSGARAPQEVLRERLIAELQEKDPDAALTQLQREVHARPSLARHCAGLARALGEAAVAKYGVARAQSFSRPVCDTAFASGVVAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6X0</accession>
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        <submittedName>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_13735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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    <dbReference type="EnsemblBacteria" id="AKH83119">
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        <property type="gene ID" value="AA958_13735"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_13735"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2891"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
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    </dbReference>
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    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="48"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="81"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="134" mass="13464" checksum="307B4F2D77CA80E9" modified="2015-07-22" version="1">MSGVDEPAHDPAVFELATKAFELARQGQTDTLAAYVDAGVPAGLRDDDGNTLVMLAAVNGHPRTVAALLQRGADADQVGAAGATPLAAAVRAGADDVVRVLLRHGADPQAGSPSAVATARVAGRTELLELFGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6X3</accession>
    <name>A0A0F7N6X3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_13770</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
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            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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    <dbReference type="EnsemblBacteria" id="AKH83124">
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        <property type="gene ID" value="AA958_13770"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_13770"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2900"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
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    </dbReference>
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        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:phosphorelay signal transduction system"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="55"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH83124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="471" mass="49477" checksum="360608B351FB4092" modified="2015-07-22" version="1">MAETQAATRRRHPLPSAAHAPSPQPHAPLPAQRSGHGPVPGQPHARQRAVPEALTLLLIEAEPGSGPGIARLLEQAGAGRHGERIRVRTARNLTEAERLLGPDVHCILLDLSVTGEAAAADDGEPAEEGDELGALREVLAMAPLHAVLTLTDEDDVELAAEAVRVGAQDYLFRGELDGRVLGRAIRYAVERKRADLAQSRLTASRLRAQENARLERGLLPTPLLAGSGLGFAACYRPGLPPPAAGATPTRALLGGDFYDAVRTPDGAVHAMIGDVCGHGPDEAALGVELRIAWRALTFAGLVGDELLATLQQVLENERADDEIFATMCTVDVSPDARRAGLYLAGHPAPLVAVPGGRPRLMPQELGGPALGLLPRARWPRQQVELGGAWSLMLYTDGLIEGRTGPGRGRLGQDGMLALVGRLLDQGLAGDDLLHGAVTEARALNGGDLTDDVAVLLLDRPPGPCGPGDRMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N722</accession>
    <name>A0A0F7N722_9ACTN</name>
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    </protein>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
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        <lineage>
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            <taxon>Streptomycetales</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_14175"/>
    <dbReference type="EnsemblBacteria" id="AKH83189">
        <property type="protein sequence ID" value="AKH83189"/>
        <property type="gene ID" value="AA958_14175"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_14175"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2984"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="49"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="418" mass="46727" checksum="FFA3C652CC9B8517" modified="2015-07-22" version="1">MLLRARVANVRSLRDEQELSFVAPDEEPGAAVRDVRLGGERSAAVFPLIGIFGANASGKSNVLRALADMRRAVLDSYGRWASYEGVSRKPFALDAKSESEPSFFEVDLVMDEVRWTYGFELGPKRVESEWIHSYPRGHRQVWLDRDASRPEVFEWPGGRVKDRNQLVRRTRPNALLLSTAGTDNHPQLSPLFHWFRRNLWLINPEDERAERERYTMNQLTGDRASRIKELLRVADLGVTGAEYVPESAGGPTVTLTHRSAAGEVNLDWKNESLGTRSWFALLGPLLLALDEGAVLLIDELNASLHPRFAAEVVRLYHDPLSNPKGAQLVFTTHDPSVLTTPSGERLLEPGQVWLTEKDKDGATELYSMTAASPGEREDLAKSYLAGAFGAVPDLLEGQIARRLLATTEQEREYEAERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N793</accession>
    <name>A0A0F7N793_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_18975</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EccE family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017226.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_18975"/>
    <dbReference type="EnsemblBacteria" id="AKH83931">
        <property type="protein sequence ID" value="AKH83931"/>
        <property type="gene ID" value="AA958_18975"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_18975"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3983"/>
    <dbReference type="OrthoDB" id="827116at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021368">
        <property type="entry name" value="T7SS_EccE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11203">
        <property type="entry name" value="EccE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH83931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="492" mass="52152" checksum="E57B62F75BECA364" modified="2015-07-22" version="1">MSDPSAAPVTVKFPHRSRRGILLGLSLPQLVLVSSTLALLLMTVVTTGLIGAVVLAPLWAASAALVAVRRHGRSLIDWAPITARYALRRHTGQNLWLARPVTRPRHDGILHLPGTAASLKVVTPGDSATGAAAVHDPHRQTLTAIARVTGPAFVLLDPATQNQHVAGWGRALAGIARSGHIATVQVLERTVADSGDSLARHFTRTAHAQTQAPVAGQIYSELLTSASPAAAPHETYLAISLDLKAARRLISQAGGGLTGAFTVMAQTTTSVAQAARNAGLLATGWLTAQEIAAVIRTAYDPNALPALQQWSTTGRAEADPAAAGPVVQVEEYDRLATDSARHATYWVENWPRTESNAAFLHGLMFTPGVRRTLSLIYVPQGLQAALRDVQRKKAAIIADANERARRGQVDSEEDSVEYADVKTRERQLLAGHADVALTGLVTVTAATDALLDTACAQIETHAVTAGVDLRRLNYQQPDAFTITALPLARTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7N3</accession>
    <name>A0A0F7N7N3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_15580</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S58 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016706.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_15580"/>
    <dbReference type="EnsemblBacteria" id="AKH83394">
        <property type="protein sequence ID" value="AKH83394"/>
        <property type="gene ID" value="AA958_15580"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_15580"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3279"/>
    <dbReference type="OrthoDB" id="2000083at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016117">
        <property type="entry name" value="ArgJ-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005321">
        <property type="entry name" value="Peptidase_S58_DmpA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36512">
        <property type="entry name" value="PTHR36512"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03576">
        <property type="entry name" value="Peptidase_S58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56266">
        <property type="entry name" value="SSF56266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="231"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH83394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="400" mass="40542" checksum="3BE144863AF8DB21" modified="2015-07-22" version="1">MSEERGRARDFGIPLTGEPGEWNAITDVPGVQVGYVTLVEGDDVRTGVTALLPRGRDGVGTPCAAGWHSLNGNGEMTGTAWLEESGALAVPVLLTNTYAVGPVHRGVVEWVRTHRRDIAPEWLLPVVTETWDGYLHDIHGAHVTPAHAGAAIDAAAGGPVAEGGVGGGTGMRCYGWKGGSGTASRVVRYGSERYTVGVFVQANFGARRELVVAGTPLGRAAAEAAEVAEAAEAAREGGGGSGGGTGAGGGPGAERPVPPGAGSVIVVVATDAPLLPGQCKALARRVPLGLARTGTTGSHFSGDLFLAFSTANQGALTSTFPPRPAADGDAGGAGDDAPYETLRFIPWGRVDPFHAAVVEAVEEAVLNVLTAAGPMTGRDGHHVPAFPLAALAGLRGARTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7X4</accession>
    <name>A0A0F7N7X4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Arginine--tRNA ligase</fullName>
            <ecNumber evidence="9">6.1.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Arginyl-tRNA synthetase</fullName>
            <shortName evidence="9">ArgRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">argS</name>
        <name evidence="13" type="ORF">AA958_20240</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg)</text>
            <dbReference type="Rhea" id="RHEA:20301"/>
            <dbReference type="Rhea" id="RHEA-COMP:9658"/>
            <dbReference type="Rhea" id="RHEA-COMP:9673"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78513"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.19"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.19" evidence="9"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017415.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_20240"/>
    <dbReference type="EnsemblBacteria" id="AKH84126">
        <property type="protein sequence ID" value="AKH84126"/>
        <property type="gene ID" value="AA958_20240"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_20240"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4262"/>
    <dbReference type="OrthoDB" id="1146366at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004814">
        <property type="term" value="F:arginine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006420">
        <property type="term" value="P:arginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00671">
        <property type="entry name" value="ArgRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00123">
        <property type="entry name" value="Arg_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001278">
        <property type="entry name" value="Arg-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005148">
        <property type="entry name" value="Arg-tRNA-synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036695">
        <property type="entry name" value="Arg-tRNA-synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035684">
        <property type="entry name" value="ArgRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008909">
        <property type="entry name" value="DALR_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956">
        <property type="entry name" value="PTHR11956"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03485">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05746">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00750">
        <property type="entry name" value="tRNA-synt_1d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01038">
        <property type="entry name" value="TRNASYNTHARG"/>
    </dbReference>
    <dbReference type="SMART" id="SM01016">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00836">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55190">
        <property type="entry name" value="SSF55190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00456">
        <property type="entry name" value="argS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arg_tRNA_synt_N" evidence="12">
        <location>
            <begin position="9"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="DALR_1" evidence="11">
        <location>
            <begin position="477"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="9">
        <location>
            <begin position="125"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AKH84126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="593" mass="64518" checksum="C681E5689264BB9B" modified="2015-07-22" version="1">MASVPSLATQVRQRVADALAAALPQEADADPLLRRSDRADFQANGMLALAKRLKTNPRELAGQVAERVDAGDVLADVEVSGPGFLNIAVTDAAITSNLAARAADDRLGVPYADAPGTTVIDYAQPNVAKEMHVGHLRSAVIGDSLVRVLEFTGETVVRRHHIGDWGTQFGMLIQYLDEHPHELDHGGADGAAVSGEEAASNLNRLYKAARAVFDADDAFKERARRRVVALQSGDPETRALWQRFVDESKLYFFSVFDKLDMEVRDADIVGESGYNDMLDETCELLADAGVAVDSEGALCVFFDDIKGQDGQPVPLIVRKSDGGYGYAATDLSAIRDRVFNLKAQTLLYVVDHRQSLHFRMVFETARRMGWLDGDVTATQLAFGTVLGKDGKPFKTRAGTTVRLEDLLDEAIDRASSVVREKADKAVPPLTEAEIAERGAQVGIGAVKYADLSTSAARDYKFDLDQMVSLHGDTSVYLQYAYARIRSILRRAGDTAHPAAHPELALEPAERALGLHVDGFAAVVAEAAEEHAPHKIAAYLYQLASLFTTFYEHCPVLKADTPAQVENRLFLSDLTARTLNTGMSLLGIRTPERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N805</accession>
    <name>A0A0F7N805_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_12580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016262.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH82927">
        <property type="protein sequence ID" value="AKH82927"/>
        <property type="gene ID" value="AA958_12580"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_12580"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2643"/>
    <dbReference type="OrthoDB" id="1785875at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH82927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="166" mass="18432" checksum="6DDB3D8CF32BC44C" modified="2015-07-22" version="1">MDPVTTADQYRTVVIEGCDGTGKTTLARRLTGRHGFSLIHATRTPDHLDLTTRYLHMLGTDSRLVMDRSFVSELVYGPLQRGRSRLTWAQVLDLAEAVTQRNGAFIHLTAPVDVVHARLLLRDGEADEPSALTDLLVAYERAFRTLADYATVITIDTAQHDLRSTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N849</accession>
    <name>A0A0F7N849_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FAD-linked oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_16800</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016898.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH83594">
        <property type="protein sequence ID" value="AKH83594"/>
        <property type="gene ID" value="AA958_16800"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_16800"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3534"/>
    <dbReference type="OrthoDB" id="330793at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006093">
        <property type="entry name" value="Oxy_OxRdtase_FAD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00862">
        <property type="entry name" value="OX2_COVAL_FAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519227" evidence="2">
        <location>
            <begin position="33"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="3">
        <location>
            <begin position="74"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH83594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="549" mass="58127" checksum="3BF0978E36FC79A9" modified="2015-07-22" version="1">MSASTRRGLLRAGAVAAVAAPAAAYTAPRAHAAPQAAAEGAAGTAAGAAFGPVTVRPDDPRYASLRLRGYNHRHASHPSRIRLVGTTADVVRAVSDALRTGGRLAVRSGGHCFEDFVDHPGTDVIIDMSGMRAVGYDPARRAFAVEAGATLAEAYRRLFLGWGVTVPGGTCPGVGAGGHVAGGGYGALCRLYGLTVDHLYAVEVVVADRSGRARSVVATREPSDPHRDLWWAHTGGGGGSFGVVTRYWFRSPDAAPGAEPGDLLPRPPATVLTYSLIWHWADLDEDAFATLMRNYARWGERNSAPGSPAAALYGEFAMTTSPGGTLGIAGQVAAGDTAARRLLDDLQGALTGGRGVPPPARQAETLPWLSATLAHSGADAVPFAARMKIKSGYRRRGFSAAQLTTLYRSLTDPAYDNPFGSVFLNTYGGQVNAVSPGATAMPHRDSVFLAGFLTGWTGEDEDERQLRWLRELYGKLYARSGGVPAGPDDSGTFINYPDNDLADPAHNTSGTPWHTLYFGEDGYARLQRAKERWDPRNVFHHGLSVRPLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N887</accession>
    <name>A0A0F7N887_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LuxR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_20960</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017536.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_20960"/>
    <dbReference type="EnsemblBacteria" id="AKH84251">
        <property type="protein sequence ID" value="AKH84251"/>
        <property type="gene ID" value="AA958_20960"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_20960"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4417"/>
    <dbReference type="OrthoDB" id="930905at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="2"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="144"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH84251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="214" mass="23336" checksum="20858A92A4DAC07E" modified="2015-07-22" version="1">MRVVLADDSTLLREGLARLLADEGHEVTAAVGDAPALVVAVAADPPDVAVVDVRMPPGHSDDGLRAALEIRERWPETGVLVLSQYVERRYATELVTGSTGGVGYLLKDRVVQVDEFLDALDRVAAGGTALDPEVVRRLLAHSTRTDPLDRLTPREREVLDRMAQGHTNATIAARLHVSQSAVEKHVNAIFDKLDLGHTQGYSRRVLAILRYLEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8E1</accession>
    <name>A0A0F7N8E1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_17470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017003.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_17470"/>
    <dbReference type="EnsemblBacteria" id="AKH83699">
        <property type="protein sequence ID" value="AKH83699"/>
        <property type="gene ID" value="AA958_17470"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_17470"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3674"/>
    <dbReference type="OrthoDB" id="416257at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="70"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="300"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="354"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="396"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="422"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="457"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH83699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="486" mass="52874" checksum="2493A9D9E3A5A8BC" modified="2015-07-22" version="1">MTHADDHVTPPRSSPFPLRTQNLPAPEVRELPAPPKRVWPIIGPGVVAAGVGLSSGEFILWPYIASQAGLVFLWGAVVGVLTQWFINMEVERYTLATGETAVSGFNRYWKHWGAVMVVFTYAANLWPGWATSSATMLSYVFGGDPAIIGICLLAAIGAMLTLAPVVYNALEKLLFFKLAVVAVFFVLAVVLAVEASSWGDLPDGVTHIGQFPTELGVAVLMGAIAYAGAGGGQNLCQSNWIRDKGFGMGRYVPRLVSPITGKEEAASTTEAPAGYVFDPADHENMSRWQRWWRLANLEQGMTFVLVTIVTITLTSLLSHSTVFGVEGLANDVSFVEAEGEELKSAVGGWFGTTFWLIGAFSLFTAATGIVDYTSRMAADILKSTYLRQHPVSESRLYFWLVWGVVAVGALILLIGFDQPLVLLVISACVSGLMMFVYSILLLVLNRKSLPPPLKIRNYRVAALIWAVLLYGTLAALTIRQQYIDNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8P8</accession>
    <name>A0A0F7N8P8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_21965</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017678.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_21965"/>
    <dbReference type="EnsemblBacteria" id="AKH84416">
        <property type="protein sequence ID" value="AKH84416"/>
        <property type="gene ID" value="AA958_21965"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_21965"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4625"/>
    <dbReference type="OrthoDB" id="1857352at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH84416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="150" mass="15529" checksum="A3756AFD19CAD472" modified="2015-07-22" version="1">MTTTAPAANARSLALAHYAARGVLEHVLARHGVTFQQQIALRAAVTADAPQTADDLVAQVRGSLKADPADIRATLDELLARELLVADAAHLRPTDAGRELLAAVGAETAPFSARIWGGIAAEDLAAAGRVLALVNERANAELAALTDAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8T1</accession>
    <name>A0A0F7N8T1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_18840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017210.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH83913">
        <property type="protein sequence ID" value="AKH83913"/>
        <property type="gene ID" value="AA958_18840"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_18840"/>
    <dbReference type="OrthoDB" id="1831625at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH83913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="198" mass="20912" checksum="B4D888EC76198C5D" modified="2015-07-22" version="1">MNLTAPAEHLLDLAQKFTCHNDDLARLRVTLARHGLSGSSPATALTDHAAVTQRLANAALDIVDVLKAQPMYLSPAIRTVYARVWQLAYLVSDSTDHLLDAVDIIDDTRAAIPGLLPGAQNSNEAGVHGADEVSGDSGGVVGKVSSSLARCRTKACLRRLHDGRGGSGRGRTCVRAGVGRDRCWWLSLPGEARAAGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8V9</accession>
    <name>A0A0F7N8V9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_19040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017238.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH83943">
        <property type="protein sequence ID" value="AKH83943"/>
        <property type="gene ID" value="AA958_19040"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_19040"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3997"/>
    <dbReference type="OrthoDB" id="1573516at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH83943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="167" mass="17654" checksum="3070173B8D596581" modified="2015-07-22" version="1">MTTTPGPSELRAAARVLASPALIRLITEIDDNGPIPPRTLTATLPDLTRSSARRAVHMARAHGLVQAGPAGGLDLTDSGFHLAAFYDATARWARHHAYPTPVSTFTTRIQHTLDLLVHLLATQSADGSGADLPGAEAAGEDLPGLLIRWLTANPQLTQPVTEYEPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N932</accession>
    <name>A0A0F7N932_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_19020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017234.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH83939">
        <property type="protein sequence ID" value="AKH83939"/>
        <property type="gene ID" value="AA958_19020"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_19020"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3993"/>
    <dbReference type="OrthoDB" id="1806189at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="156" mass="16466" checksum="EA20F175E4D76ACD" modified="2015-07-22" version="1">MSDDIPENADDIVSVFTERVEAQFDMTIGELKAAAAARPDANPHATDVVRWHGLLVDAQEVLDSAVDDLRAALDTQPGQLDDPTMDLAQWVNAAVTARDGRALVVRYLLDPDALGNHTTPRRKGPAVQTTAPARPAAGPASTPAQAAPRAAGRARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N959</accession>
    <name>A0A0F7N959_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ATP-dependent DNA helicase RecG</fullName>
            <ecNumber evidence="2">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_25815</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. RecG subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="2"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018314.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_25815"/>
    <dbReference type="EnsemblBacteria" id="AKH85070">
        <property type="protein sequence ID" value="AKH85070"/>
        <property type="gene ID" value="AA958_25815"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_25815"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5437"/>
    <dbReference type="OrthoDB" id="234717at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045562">
        <property type="entry name" value="RecG_dom3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033454">
        <property type="entry name" value="RecG_wedge"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19833">
        <property type="entry name" value="RecG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17191">
        <property type="entry name" value="RecG_wedge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="287"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="512"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="513"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH85070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="756" mass="81079" checksum="4EF8A8248A309E4E" modified="2015-07-22" version="1">MSVLEEPLKTSVGDRTAKAMAEHLDLHTAGDLLHHYPRRYAERGELTRLADLEIDEHVTVVAQVEKAAMLGTGRGRRLEVVITDGSGRLTLVFFGRGAYHPQKELLPGRRALFAGKVTVFNRKRQLAHPDYKPLSGKDGAGADAEADEWAGKLLPLYPACRQLASWQLQQAVDTVLDGLEATGWEGVADPLPAALRAERGLVPLREALLKVHRPKTKADLWAARDRLKWDEAFVLQVALARRRHADGQLPAVPRVAPAGGLLADFDARLPFTLTEGQQRVSADIFADLATDHPMHRLLQGEVGSGKTLVALRAMLAVVDAGGQAAMLAPTEVLAQQHHRSITEMMGELAEAGLLGGAEHGTKVELLTGSSGAAARRKALLDLATGEAGIVVGTHALIEDKVHFHDLGLVVVDEQHRFGVEQRDALRAKGNRGDDKRTPHLLVMTATPIPRTVAMTVFGDLETSVLDQLPAGRSPIASHVVPAADKPHFLSRAWERVREEVEGGHQAYVVCPRIGDSAEETEPTGGKSGKGAKGGKGAKEAPSPEDEAERRPPLAVLDVAAQLSAAPGAPLAGLKVEVLHGRMQPDAKDDVMRRFAAGEVDVLVATTVIEVGVNVPNATVMVIMDADRFGVSQLHQLRGRVGRGAAAGLCLLVTEMPEGTPARTRLDAVAATQDGFRLSRIDLEQRREGDVLGQAQSGARSSLRMLTVIDDEDVIAEARDAAAAIVAEDPELTAYPELRGALASLLDDEREQFLDKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9E8</accession>
    <name>A0A0F7N9E8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sugar ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_19870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_19870"/>
    <dbReference type="EnsemblBacteria" id="AKH84064">
        <property type="protein sequence ID" value="AKH84064"/>
        <property type="gene ID" value="AA958_19870"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_19870"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4187"/>
    <dbReference type="OrthoDB" id="447734at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
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        <property type="entry name" value="SBP"/>
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        <property type="entry name" value="TAT_signal"/>
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        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="466" mass="49720" checksum="83B8CA3B6819291C" modified="2015-07-22" version="1">MLHHGNGAVPARGAPARRRTPGAPSRRRFLGGTAGAAAAATAAATPLLSGCGSASADGGTLKFWHFYDPKASDPAMVAQSKWFDKLVKDWNDTHDVKIEPYFVPGVSYQGSKMVTAFAAGAGPDIFLLSPGDFTRYYNGGILADLTPHLDDGVVEDYGTSLTSRTVGGKVYALPMEVEPLAMFYNVPVWEEAGLSEADIPTTWDQLLDAGDKIRSKTGAAGLVFHTDPGYYQNFTWYCWMWQGGGEVVDKAGNVAFDSKGARQALALWQDAVEAGIAPRTLPAADDRITAFTSGLAGMWQIGIWEVQAFKAGAPDHEYGVFKLPVPPGGEYTTTLGGWSFCASTQGANPDAAAEFCGWALGGMSDESIDRTVEWCTGVKSDISPRTSALERGAERGGYDSWAMKKFKEDIFPGGRAEPRYPPIVYKAISDAIQATMLAGKGVEGEADRAAQTIDAFMKSYQGASLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9F9</accession>
    <name>A0A0F7N9F9_9ACTN</name>
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        <submittedName>
            <fullName evidence="9">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AA958_20445</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
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            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017452.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_20445"/>
    <dbReference type="EnsemblBacteria" id="AKH84163">
        <property type="protein sequence ID" value="AKH84163"/>
        <property type="gene ID" value="AA958_20445"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_20445"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4309"/>
    <dbReference type="OrthoDB" id="2063795at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027379">
        <property type="entry name" value="CLS_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13396">
        <property type="entry name" value="PLDc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="PLDc_N" evidence="8">
        <location>
            <begin position="12"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="66"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="91"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH84163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="126" mass="13632" checksum="06587CC6652349F0" modified="2015-07-22" version="1">MLRYLPFLLVLAVWIYAFIDCLNTPERDVRNLPKLVWVAIIVLFGSVLFGPLAWFIGGRPRGRPVIAGEGAGGGGRRPGRGGWVAPDDNPEFLKKLGDVNAKDDEGKDDGGDGDGDGKRDGDPRTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9J3</accession>
    <name>A0A0F7N9J3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Carbon starvation protein CstA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AA958_23660</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptide transporter carbon starvation (CstA) (TC 2.A.114) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_23660"/>
    <dbReference type="EnsemblBacteria" id="AKH84706">
        <property type="protein sequence ID" value="AKH84706"/>
        <property type="gene ID" value="AA958_23660"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_23660"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4987"/>
    <dbReference type="OrthoDB" id="457782at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025299">
        <property type="entry name" value="CstA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003706">
        <property type="entry name" value="CstA_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02554">
        <property type="entry name" value="CstA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13722">
        <property type="entry name" value="CstA_5TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="169"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="298"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="335"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="376"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="475"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="517"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="552"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="583"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="650"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="domain" description="CstA" evidence="10">
        <location>
            <begin position="43"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="CstA_5TM" evidence="11">
        <location>
            <begin position="474"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="711"/>
            <end position="738"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AKH84706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="738" mass="78071" checksum="1E11170E9D1E823A" modified="2015-07-22" version="1">MQAPPDVPKKPRLEPKSVILWTVVALVGAIGWTMLALSRGEEVSAAWMVAAALGSYAIGYRFYSKFIAYRVLKADKTRATPAERLDNGIDFQPTDRRVLLGHHFAAISGAGPLVGPVLAAQMGFLPGTIWIVAGVIFAGAVQDMVVLFFSTRRNGRSLGQMAREEIGPFGGAAALLAVFAIMIILLAVLALVIVNALAESPWGTFSIGMTVPIALFMGFYLRMIRPGRVAEVSLIGIALLLLALVAGRWVAESSLADTFTLSKESLVIWMVIYAFIASVLPVWMLLAPRDYLSTFMKLGTIALLFIGVVVAAPTLKMDGVTDFAGEGTGPVFAGSLFPFVFITIACGALSGFHSLISSGTTPKMVQKETQIRMIGYGSMLMESSVAIVAMIAACVLDPGLYFAMNSAPTVIGDTAQSASEAIQGFGYEITPAALQAAADSVEESTLLSRTGGAPTFAIGVSEIFSDVTGDSLKAFWYHFAIMFEALFILTALDAGTRVGRFMLQDTLGNVYKPLKRVSWWPGLIATSAVVVGLWGYFLWVGVNDPLGGINQLFPLFGITNQLLGAVALTICTTLLIKSGRLKWAWVTGIPLIWVAVVTLTASWQKVFSDDPRVGFFAQGDVAQEGIDSGKLSGQELEDAETIVTNTTVDGVLSAVFALLVVVVILDAARVCVKSLRNPESVVSHEEPYHESSYVAPAQLIATKEEKEELAAAGLGSGGGFKPGTGPGAGGGARDGGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9W7</accession>
    <name>A0A0F7N9W7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">50S ribosomal protein L10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rplJ</name>
        <name evidence="6" type="ORF">AA958_21045</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017547.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_21045"/>
    <dbReference type="EnsemblBacteria" id="AKH84264">
        <property type="protein sequence ID" value="AKH84264"/>
        <property type="gene ID" value="AA958_21045"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_21045"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4432"/>
    <dbReference type="OrthoDB" id="1470978at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05797">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00362">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022973">
        <property type="entry name" value="Ribosomal_L10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_L10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001790">
        <property type="entry name" value="Ribosomal_L10P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11560">
        <property type="entry name" value="PTHR11560"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="SSF160369"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH84264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="184" mass="19127" checksum="F8F51E3567FCC29D" modified="2015-07-22" version="1">MATPDKVEAVKEIADKLRGSNAAVVTAYTGLSVAQLKDLRRSLGENAQYRVVKNTLTKIAAKEAGLDQLDEHLQGSTAVAFVTGDPVEAAKGLRNFAKDNPALVIKGGVLDGKALTADEINKLADLESREVLLAKLAGGMKASMAKAAATFQAPLTKFVRTADALRDKVEQGGAGTPAPADAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NA28</accession>
    <name>A0A0F7NA28_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PAC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_16600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016867.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_16600"/>
    <dbReference type="EnsemblBacteria" id="AKH83562">
        <property type="protein sequence ID" value="AKH83562"/>
        <property type="gene ID" value="AA958_16600"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_16600"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3493"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAC" evidence="1">
        <location>
            <begin position="268"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="999" mass="106959" checksum="D44F6F8C3D196D8F" modified="2015-07-22" version="1">MHSESGRGGRPGETPGAAMDDDLRLGWVAGLPADADVTRVLGLALPHAVAGAAGLGGLVHLSGREPGTLDLAAVIGLPPDLTGAWDHLGDAATPGLAPARAIATGRPVWSQARPPTPDRTQGHPRGVLSVPLRAGGDVIGALSVLADREPPRDRVHYLGQVAALVGDRLASARRWRSSGTHPWWEIGTDEIPAEHRLMRAVRAGRWSWDLSTGLLDTDEVAESLLVKAGIDRYDWDHHILTWLAHIYPADRGQVEQEITRSRREDSAYVVEYRVQDSAGRLSWLLVCGWWEHDDTGRLVRMVGYTWDVTDRRSSEAWLAGLTDSYPLPTYVIAPDDHVTWCNAVAREVAALRQVEIVGRVPWEVFPELREQGVPDVLAAARAAPGRPASKTVTSWEAFRGDSGGLGHYEVNAVGITDYVVVTLTDVTDKAEAAEAAAERRERLTGLNAALIQACTPRHVVDAVLTHVVPLLSADSALIHDLTGPEPQVAGSRGCSPELLRQVAMLSWQERMEARAVASAQIQLVKSVGELAERWPHLVPLARMGRGQAWAIVPLVTADAQVGSVVLGWHTPRVFDGEAEALLGTVAVAVAAAFARAAEFREAQQRAERLQHELMPGRLPALTAASAAAQYRTASTAGIGGDWYDAIALPGGRTLAVVGDVAGDGIDEPVVMGILRQAIAAIAAMDLVPDELLAYANDVTLRLGSVQATVLLALYDPATGVLSLTSSGHPPPLMMAPGRPPAVLDMPIGKPLGLPHVPPEVAEVTVPDGTLLTLYTDGLLGLDDPDPARLAEVITRHAVSTPLPSDPARRAPWLDDLCHAAMATLLPESRPDDAALLALTLGRIPADHIATWDMPRIPESAQTARATVSDRLQRWGLDALVWPADQVVSELVGNAVRHAVGIGVSAAHAAVGDIRVRLLRLVDQLVIEVYDGSKAAPYVRHPSYDQEFGRGLPIVSVLAHRWGTRRVGTDEPDDADPTTPSKCVWAALSLTEERDDQVFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAB9</accession>
    <name>A0A0F7NAB9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_25400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018247.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_25400"/>
    <dbReference type="EnsemblBacteria" id="AKH84996">
        <property type="protein sequence ID" value="AKH84996"/>
        <property type="gene ID" value="AA958_25400"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_25400"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5354"/>
    <dbReference type="OrthoDB" id="1255066at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027945">
        <property type="entry name" value="SseB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009839">
        <property type="entry name" value="SseB_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07179">
        <property type="entry name" value="SseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14581">
        <property type="entry name" value="SseB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SseB" evidence="1">
        <location>
            <begin position="21"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="SseB_C" evidence="2">
        <location>
            <begin position="146"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH84996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="257" mass="27317" checksum="9EC29D1881F3617C" modified="2015-07-22" version="1">MSFDYRSPQPPATGGFPGNELEEVLAASLGNPQAAPRLLEVLGRSSLWVPLPAGGGPDSPSLPVPTTEIGGAPYVPVFSSQEEFLRVSGSHMSFTVAPAREFARGLPPQVGIAVNPGGTVGVPLPPAAVAELCRDRGAARLPGEARGGRVRLFTPDWQDDPVDFLAVAREEFERIGVVRSARRGLASVEGGAVQLYIGVELLDTYDESRQATVEALGRALGAQPVPWKVQLVFLDAAVDPVITWMRAKVEPFYIRVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAK8</accession>
    <name>A0A0F7NAK8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphoenolpyruvate carboxykinase [GTP]</fullName>
            <shortName evidence="8">PEP carboxykinase</shortName>
            <shortName evidence="8">PEPCK</shortName>
            <ecNumber evidence="8">4.1.1.32</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">GTP-dependent phosphoenolpyruvate carboxykinase</fullName>
            <shortName evidence="8">GTP-PEPCK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">pckG</name>
        <name evidence="11" type="ORF">AA958_22400</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>GTP + oxaloacetate = CO2 + GDP + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:10388"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="4.1.1.32"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="8">Binds 1 Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.32" evidence="8"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017754.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_22400"/>
    <dbReference type="EnsemblBacteria" id="AKH84494">
        <property type="protein sequence ID" value="AKH84494"/>
        <property type="gene ID" value="AA958_22400"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_22400"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4716"/>
    <dbReference type="OrthoDB" id="267285at2"/>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004613">
        <property type="term" value="F:phosphoenolpyruvate carboxykinase (GTP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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</entry>
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                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
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    </evidence>
    <sequence length="275" mass="30178" checksum="CA04773DB87201B5" modified="2015-07-22" version="1">MRVPRRRRWVVAVPMAALALATVYPLVFTANVAMKSRRDYILDRFSPADSLRWENIATAWTSVGLGRYFVNSVVVVASAVALLLLIGSMAGFALSHLRFRGSRALFLCFLAALFVPFQVVMVPLAQVMADTGLIDTYPGLILAYVAQFLPFSIFLMTSYYSGIPREIVDAARVDGNTLYGVYRRIMLPIGRPALLSVGILNALFCWNDVLISLLMMPSAEHRTLMVGVTSLRGQYSDDIPTFASGVLIAALPVLVIYLFFQRQIADGITAGATKG</sequence>
</entry>
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    <accession>A0A0F7NBH0</accession>
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        <submittedName>
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        </lineage>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH rpiR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="2">
        <location>
            <begin position="112"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH84052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="277" mass="28769" checksum="A0FC002BF98FB056" modified="2015-07-22" version="1">MTRSMQRVAEAVAGDPAGCAALTVTGLAERTGTSEATVVRTARLLGYPGYRDLRLALAAAAAQQEAGRAPSVTADIAVDDSMADVIAKLARDEQQALADTAAGLDPVQLEAAIAAMATARRIDVYGIGASNLVGQDLVQKLLRIGVVAHASPDPHLAVTNAVQLRAGDVAIAITHSGRTVDVIEPLRVAFDHGATTVAITGRPDGPVASYADHILTTSTGRESELRPAAMSSRTGQLLVVDCLFIGVAQRTYERAAPALAASYEALAHRHSPLRPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBM2</accession>
    <name>A0A0F7NBM2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Hemerythrin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_24445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018090.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH84838">
        <property type="protein sequence ID" value="AKH84838"/>
        <property type="gene ID" value="AA958_24445"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_24445"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5151"/>
    <dbReference type="OrthoDB" id="1701106at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012312">
        <property type="entry name" value="Hemerythrin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01814">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hemerythrin" evidence="1">
        <location>
            <begin position="15"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="170" mass="18203" checksum="9C8BA864C3199AF3" modified="2015-07-22" version="1">MSPESRARLVALGAELLAIHRGLRAQLARLREETDDYLAGGPRPRDLKAHCLAFCTALTSHHTGEDRGAFPALAARDPELRPLIAKMEQDHAMMSGLLQSLERVLDTLPEDPGEGDAARVRSELEGLSAIVESHFRFEERTIVAALDALPPEAGGAEDLLGLPGPGKDGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBX4</accession>
    <name>A0A0F7NBX4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_25050</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018184.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH84933">
        <property type="protein sequence ID" value="AKH84933"/>
        <property type="gene ID" value="AA958_25050"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_25050"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5279"/>
    <dbReference type="OrthoDB" id="498436at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="279"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="306"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="341"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="364"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="399"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="426"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="261"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH84933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="462" mass="46969" checksum="32622A7E114FBBDA" modified="2015-07-22" version="1">MPKDYGPPPAAGEAPGMSDTTAPDGAAAPVPAAPPSGRDGTGVRAAAPPGTPAGPRARYADVFRVREFRFVFAAHVMSILGEVVAAIALTVLVYDRTGSPLLSALTLGVGLLPYLVGGTLLSSIADRLPARRVLVTCDLLAAVCFALMVLPGMPVAALLALRCVAGVISPVFTGTRIATLADILGTGDRFVLGRSVIRLTAQAAQLAGFALGGLLAAFSPRATLTLTALGMLGSALVLRFGTRARPARTAAGTPGRASTVGASLAAAGTFLRDRRIRALLLLTWIPPTFVVAPEALAAAYADDLGIGALGLGLLMTGMPIGAVTSEILAGSLLGPRGRERIVFPVAVLCTVPAIGFVTHPSFGWALPLLVLTGFGISYSLGLDQWFVAAVPEEMRGRAMTLQTAGLMTLQGVGMAGAGAVAEFAPVHLAVAAVGVTGTVCSLLVCLEVRRTRPKGETGLTAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NC50</accession>
    <name>A0A0F7NC50_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_30160</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019004.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_30160"/>
    <dbReference type="EnsemblBacteria" id="AKH85776">
        <property type="protein sequence ID" value="AKH85776"/>
        <property type="gene ID" value="AA958_30160"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_30160"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6369"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13492">
        <property type="entry name" value="GAF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAF" evidence="2">
        <location>
            <begin position="40"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="3">
        <location>
            <begin position="299"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH85776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="390" mass="41446" checksum="FEB33C3FADA64CC1" modified="2015-07-22" version="1">MSPYRHRPGELVRRREPSRFTERWLEATADITAGLLSGLEEPAVLEMIVERARRILETDLGVLALAEGGSGRLRVALASGKEAETYQGVLLPCRGSFAGAAAEAGKPLTSADLSRDPRITAGSPGARRPGPAVAVPMVAEEGVRGVLLLARSDPLDVFTDVETGPLLAFAGQAAIAMELADRRRDAEQVALLKDRDRIARDLHDLAIQRLFATGISVQSALRFVEHEEARARLLRAVDELDETTRIIRSTIFGLRTGRGAAGGGLRAQVVRAVEDAVPVLGFTPSLRLEGLIDTDVPADVADAVRAVLGEALTNVGRHARASAAEVVLTVTDGTTTLSVQDDGVGMPRGGRRSGLANLADRAEKLGGRFSVTAPREGGTCVTWSVPLTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCI6</accession>
    <name>A0A0F7NCI6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_26500</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018427.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_26500"/>
    <dbReference type="EnsemblBacteria" id="AKH85189">
        <property type="protein sequence ID" value="AKH85189"/>
        <property type="gene ID" value="AA958_26500"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_26500"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5577"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
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        <property type="entry name" value="Put_sensor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
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        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="458"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="504"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="Sensor" evidence="3">
        <location>
            <begin position="17"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="2">
        <location>
            <begin position="245"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH85189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="534" mass="56918" checksum="B6E76A1D002E1CF7" modified="2015-07-22" version="1">MGRPRRYATALGRALVLVALAPLVTLVQAVMLASLVLAFGLGLMFVFPWAVGLTRGVANLARAVHGRWTGRPIPTAYLPAPPHPRPGPDGRYRHLGISYRSPALPEFFERVHRLLSDRATWRDTLWLVADPVVGFAMAALPLFAVGYGLAGMALPLLWDPSYPGDTLGHYAGVEVASEGTALALVPVGAALFALGLWAGPRSMALHARWTRMLLAPTRASELALQVAELDRKRTAATDWQAAEVRRIERDLHDGPQARLVALGMTVSAAEELVDDDPAAAKALLRQAQESSSMVLQELRGLVRGIHPPVLAERGLGDAVRALALDSALEVRVEVDLRGRLPDPVQSAAYFAVAELLANAGKHAGADRVDIDLWHRDGVLRATVTDDGRGGALPVTGGGLRGVERRIKPFDGVLAISSPEGGPTTVVVEIPCPLGEECCEPDDAAPGAARGAAAGRGELWLTALAPVLCSVALFPQGLVAGLLLIFGTDNRSWFLALYMPEPLRWPTVLAMVALGLSGVPPLLRRWRKTGSAQRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCK0</accession>
    <name>A0A0F7NCK0_9ACTN</name>
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        <submittedName>
            <fullName evidence="6">Iron ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_26040</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85108.1"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_26040"/>
    <dbReference type="EnsemblBacteria" id="AKH85108">
        <property type="protein sequence ID" value="AKH85108"/>
        <property type="gene ID" value="AA958_26040"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_26040"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5483"/>
    <dbReference type="OrthoDB" id="1200451at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015408">
        <property type="term" value="F:ABC-type ferric iron transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
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        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013611">
        <property type="entry name" value="Transp-assoc_OB_typ2"/>
    </dbReference>
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        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TOBE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="2"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH85108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="339" mass="35438" checksum="3079A95AEFDE6A01" modified="2015-07-22" version="1">MLVLDDVTVRYGARAAVDGIALDVADREIVSVVGPSGSGKSTLLRAVAGLQPVAGGRVLLGGRDLAGVPAHRRGVGLMFQDQQLFPHRDVGGNVSFGLRMHGAPRAAARERVAELLSLVGLPGAQRRAVGALSGGEQQRVALARALAPSPDLLMLDEPLGQLDRSLRERLVVELRQLFGRLGTTVLAVTHDQGEAFALSDRVVVMREGRVAQTGTPVEVWERPADEFVARFLGFANVVRGTVRGSAAETPWGRVGVAGAGVSGEHSLLVRPAGVRVRPAGTGLDCAVVGRTFRGDHVLLTLRPDTGPELESSVALRGAPEAGARVGVEFDPSEVVVLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCN0</accession>
    <name>A0A0F7NCN0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Rare lipoprotein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_31290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019184.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_31290"/>
    <dbReference type="EnsemblBacteria" id="AKH85956">
        <property type="protein sequence ID" value="AKH85956"/>
        <property type="gene ID" value="AA958_31290"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_31290"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6611"/>
    <dbReference type="OrthoDB" id="1502015at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH85956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="141" mass="14676" checksum="2AC0AD638A592980" modified="2015-07-22" version="1">MACSTNYLWRGEATWFCCGAAWGPCGSAGGGACGNCRSASNHGAWPNASAACWDITRPDLCGEGGIPRRGCGSVMRVVQECSKAAVCITITDCGPRTKSFCGEASCCNGVCRTNRILDLTPAAYSQIASLSSGKTGVWIYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCN7</accession>
    <name>A0A0F7NCN7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_22315</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017738.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH84477">
        <property type="protein sequence ID" value="AKH84477"/>
        <property type="gene ID" value="AA958_22315"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_22315"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4699"/>
    <dbReference type="OrthoDB" id="2027466at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH84477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="90" mass="10019" checksum="B48B8741C46F16D0" modified="2015-07-22" version="1">MSTGWRWEYDPDRVHVADGLPEHVVAEVERLAGDLVELAGTGIDITDLDHGPRPGSLRRMDAAGGWFYFLPVPRDRLIAVVRIVPPFDAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDP3</accession>
    <name>A0A0F7NDP3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_24325</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aromatic prenyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH84817">
        <property type="protein sequence ID" value="AKH84817"/>
        <property type="gene ID" value="AA958_24325"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_24325"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5125"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd13931">
        <property type="entry name" value="PT-CloQ_NphB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033964">
        <property type="entry name" value="Aro_prenylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020965">
        <property type="entry name" value="Prenyltransferase_CloQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036239">
        <property type="entry name" value="PrenylTrfase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11468">
        <property type="entry name" value="PTase_Orf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00036">
        <property type="entry name" value="Aromatic_Prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01163">
        <property type="entry name" value="II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143492">
        <property type="entry name" value="SSF143492"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH84817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="305" mass="33940" checksum="99DC7235FA92EDD5" modified="2015-07-22" version="1">MSGAADVERVYSAMEEAARLLDITVSREKVRPALEAYHEVLADAVVVFSMASGRYATELDFSISVPAEAGDPYRVALAKGLTPRTDHPVGRLLADTQEHCPVSMFAFDGEITGGFKKTYAFFPTNDLQSASKLAEIPSMPDSVKENADLFARYGLDKVQMTSIDYKKKAVNLYFSEMSPDILGPDTVRSMLRDMGLKETGETGLTFARRSFSVYPTLNWETGRIERLCFAVISRDPTLAPAERAEDLAKFSKYANNAPYAYAGEARTLVYGLTLTPREEYYKLGSYYQISDIQRKLLKAFDSLND</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDX5</accession>
    <name>A0A0F7NDX5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_28965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018841.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH85608">
        <property type="protein sequence ID" value="AKH85608"/>
        <property type="gene ID" value="AA958_28965"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_28965"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6103"/>
    <dbReference type="OrthoDB" id="1997513at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="150" mass="15195" checksum="C90205EA839E35F3" modified="2015-07-22" version="1">MDPVSVALLAALAGGAGSEAGRQAWTGLSALVRRPFRCGQGDSPEAPAISSGEAELTRLAEAPTDPARAQALSTALAVRAVLDADFSAGLQRWHEQARLVRTGDGEVHNTISGGTFSGPVLQGRDFSGVSSTPLPPPATAPGVSTPPVDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NE04</accession>
    <name>A0A0F7NE04_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Phosphonate ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_29510</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018918.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_29510"/>
    <dbReference type="EnsemblBacteria" id="AKH85689">
        <property type="protein sequence ID" value="AKH85689"/>
        <property type="gene ID" value="AA958_29510"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_29510"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6227"/>
    <dbReference type="OrthoDB" id="426495at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015416">
        <property type="term" value="F:ABC-type phosphonate transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005769">
        <property type="entry name" value="PhnE/PtxC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01097">
        <property type="entry name" value="PhnE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="139"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="253"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="336"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="396"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="527"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="552"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="87"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="390"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="280"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH85689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="581" mass="60681" checksum="FA1A88B9243851F2" modified="2015-07-22" version="1">MSQVTLPDPPRPPPVREDKARVAARPTLLGTAAAFTMLALCVLSLWAFVDLKINVATLVDSAGNAVDFLGRALPLDFPPWEELFRLARQTLAIVVCATLLSVVISVPVAVLAAANTTPTRAGRLGARGLIVLARAVPDVVLAIVFFRVFGLGAMAGVLAMGLHSVGMVGKMYADAIEQIDEGPRTAVRAAGASRLQQLATGVLPQVLPSFTANALHRFDINLRISVVLGFVGVDGLGFAIASSLRELDYPRAMALALVVLVLCILAELLSGALRRGLLPRQERRSRRPAGRSHTSSSAVPGVRKPPPVGDGQSRPAQQRTLMRVGMPWDGRRVRRTVYAAVSFAAVTGCVVAAGLGPGQFFTGLGNLPHALGLFWPPETGSILPTLLADLWVTVKIALAATLIGTVLALPVGALAARNVSPSPFVTGAFRTLIVLIRGIPELVLAIVFVVITGLGAVAGSLALGVGAIGLLGKLVADSLEEVDGGVEQALRATGAGRWQVFVSATLPQAAPALVGHVLYQLDVNIRAATLLGIVGAGGIGFQLLNASRVLEFGVVTTVMLLVFATVLVVEGLAMWFRRTVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NE24</accession>
    <name>A0A0F7NE24_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methylmalonyl-CoA epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_24990</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methylmalonyl-CoA epimerase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018173.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_24990"/>
    <dbReference type="EnsemblBacteria" id="AKH84922">
        <property type="protein sequence ID" value="AKH84922"/>
        <property type="gene ID" value="AA958_24990"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_24990"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5266"/>
    <dbReference type="OrthoDB" id="1335734at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd07249">
        <property type="entry name" value="MMCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017515">
        <property type="entry name" value="MeMalonyl-CoA_epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03081">
        <property type="entry name" value="metmalonyl_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="2">
        <location>
            <begin position="4"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH84922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="145" mass="15878" checksum="AD0090B78741C513" modified="2015-07-22" version="1">MLTRIDHIGIACHDLDATVEFYRATYGFEVFHTEVNEEQGVREAMLKINETSDGGASYLQLLEPIRENSAVGKWLAKNGEGVHHIAFGTADVDADADAIRDKGVRVLYDEPRRGSMGSRITFLHPKDCHGVLTELVTSASAPGAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NE63</accession>
    <name>A0A0F7NE63_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_03825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019758.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_03825"/>
    <dbReference type="EnsemblBacteria" id="AKH86531">
        <property type="protein sequence ID" value="AKH86531"/>
        <property type="gene ID" value="AA958_03825"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_03825"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.804"/>
    <dbReference type="OrthoDB" id="1704648at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="284" mass="29398" checksum="AB8F22DD1E1A53ED" modified="2015-07-22" version="1">MPAVPPKPVGAPLHMASVLPSDIPRPEPEPPAERRSIARTVAAAVALVTGVGLVVGAATGSLLSDGPSAQATPGAYEVARGLWHATPVDTLFPPRLEGDGAGPGGADRVWVRVAVAPPADCKEGLDAALARELRRVGCEKLLRATYTDATRSSVTTVGMVFTAAGAAKMGRFEDRFDERELAARADMLPRAYGTETGPAAGFGAEQRATWTMRVLSDAPVVLYAVTGFADGRAVTEPQPANEAVHPDATTAPAQAGLGHDAEGIADRVERGLRKTSAKATESPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NE89</accession>
    <name>A0A0F7NE89_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AAA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_30075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_30075"/>
    <dbReference type="EnsemblBacteria" id="AKH85764">
        <property type="protein sequence ID" value="AKH85764"/>
        <property type="gene ID" value="AA958_30075"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_30075"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6350"/>
    <dbReference type="OrthoDB" id="2111298at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="376"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="647" mass="68797" checksum="1FDB9496708EED16" modified="2015-07-22" version="1">MENLGIDRLDPALLAAADGLVGAVAAAVETGAARVEPSHLVITLARLPGSEAARLFDRSGIPVEAFVEALRAKSPPRTGLPPTELTAGTAARATRELLGALPAGAGERHLLAAALARLEPAAAELLVRYGRVDLDRAIGELRAEPAAPREVFGDDGRLLPDRFSPGARRVLAGLTGLAAQGGGAEAAPLPTTLLLQAMAAVPNGLVEQGCGFLGHDVRTLRTQLASLTGNGAGPSGAPGPATGAPVTLTRDGVHEPLARTLEKAAAVTAQRRGELVAERDLLAALLDTPVGLAAGFLRGTRIDITRLRRFADTLYQEHVPQEPEGDALAEMPPLHESLAWMHERLVGRESVIERLTPSLEMITRSLRRGVRLQDRPLARFLFCGRSGTGKTLAARVLAKVVYGSEDDVLFFEMGQFNTKESMNNFIGAAPGYVGFGEGKLTNGLRDNPRRVLLFDEVEKADGRVLDALLRLLDEGQISDPAGPVRDARDSVIVLTSNLGTTGPADGPDPYGYGAGEAPDGAAHMRRIMEGFFRPEFLNRIDEVILFEAFRQDQLEAIALGGLRRQAARVGTQLGVELYWQQDVPARIAELAVTRRGQEAARGVNRYIDGVFPPLLRLLDEADARGESVARARIVVDGERLSVVNGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NEU0</accession>
    <name>A0A0F7NEU0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_26790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018479.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH85242">
        <property type="protein sequence ID" value="AKH85242"/>
        <property type="gene ID" value="AA958_26790"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_26790"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5636"/>
    <dbReference type="OrthoDB" id="1938183at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH85242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="76" mass="8231" checksum="951839240587551A" modified="2015-07-22" version="1">MTTVLTPASPLTAADRCDRCGAQAYLRVVLTSGGDLLFCAHHGRKFEPELKKIAAEIQDETERLQTTPASASADER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NF23</accession>
    <name>A0A0F7NF23_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_27540</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_27540"/>
    <dbReference type="EnsemblBacteria" id="AKH87065">
        <property type="protein sequence ID" value="AKH87065"/>
        <property type="gene ID" value="AA958_27540"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_27540"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5803"/>
    <dbReference type="OrthoDB" id="1832232at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="1"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="26"/>
            <end position="33"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH87065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="244" mass="26532" checksum="EC9300CBBD2271F3" modified="2015-07-22" version="1">MKGTDFTALDGVSLDIADREFVTVVGPSGCGKSTLLNMAAGLTEPTSGDVLVDGSPVTGPGPDRGVIFQQYALFPWLTVRRNVEFGLKLAGLAADERRKRADSAIELVGLTDFADALPKTLSGGMKQRCAIARAYAVNPQVLLMDEPFGALDALTRVQLQDQLLDTWSQDKRTVMFITHDVDEAVYLASRVVVMAARPGRIHRIVDVALPYPRTEEIRLSPEFGRIRNEVWHSVYHQGAAPAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NF34</accession>
    <name>A0A0F7NF34_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sugar hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_31180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019166.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_31180"/>
    <dbReference type="EnsemblBacteria" id="AKH85938">
        <property type="protein sequence ID" value="AKH85938"/>
        <property type="gene ID" value="AA958_31180"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_31180"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6589"/>
    <dbReference type="OrthoDB" id="949956at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_3" evidence="2">
        <location>
            <begin position="36"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH85938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="513" mass="53360" checksum="8B867AC137A6603F" modified="2015-07-22" version="1">MAANNPELARLANSVLQPGFVGTTAPDWLRRRIGEGLASVVLFGRNIVHPEQVAALTAELRAENPDLIIAIDEEAGDVTRIEAGTGATRPGNLALGAVDDVELTEQVAYDIGRQLHAMGVSLNYAPSADVNSNPKNPVIGVRSFGARTDLVCRHTAAWIRGLQSAGVAACAKHFPGHGDTSVDSHHGLPHVADDAREIARTALPPFTAAMEAGVRTVMTAHMLIPAYDDTLPATLSPRIIRDLLRDELGFTGLVVTDGIEMGAVSDLYGIDGATVRALAGGVDAVCVGGENAEESVTTGLTDAIVAAVRDGSLPGERLAEAAARVHEFAAWSAALTRGVPAGDPRGGDGADHQIGLVAARRAVRVHHDPAGPARFPLAGDPHVVEFSPVTSLAIDGRTPWGVADPLRALRPGTTSVRLGESELTGAAGGAAEVLDGRALRPADGRELVVVVRDAARHPWMWQALADLLRRRPDALVVEMGLPAEDRLGAVHLSTHGATRVSGIAAAEVLTGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NF47</accession>
    <name>A0A0F7NF47_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ArsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_32100</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_32100"/>
    <dbReference type="EnsemblBacteria" id="AKH86094">
        <property type="protein sequence ID" value="AKH86094"/>
        <property type="gene ID" value="AA958_32100"/>
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    <dbReference type="KEGG" id="strc:AA958_32100"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6777"/>
    <dbReference type="OrthoDB" id="1534467at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH86094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="151" mass="17039" checksum="52E66F4FBCD51FE5" modified="2015-07-22" version="1">MDAIDRAILRELQQDGRLSNTELAERVRLTPSPCLRRVRQLERDGVIRGYRALLDGEAVGRGFHAFVTVALAQEDRATVAEFESTIRERAEVVEAHRVFGDTDFLLRVAVRDLPAYEKFNTEVLLALPGVARVTSHLTMKTVKEDRGLPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NF51</accession>
    <name>A0A0F7NF51_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_32125</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019327.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_32125"/>
    <dbReference type="EnsemblBacteria" id="AKH86099">
        <property type="protein sequence ID" value="AKH86099"/>
        <property type="gene ID" value="AA958_32125"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_32125"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6783"/>
    <dbReference type="OrthoDB" id="1112046at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="13"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="326"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="241"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="305"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="45"/>
            <end position="52"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="376"/>
            <end position="383"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH86099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="541" mass="59275" checksum="95B59195C4BE2350" modified="2015-07-22" version="1">MSFPSTPRAAASVICAGLAFTWPDGTTVFEDFDLAVGPGRTGLIGRNGTGKSTLLRLMAGELAPAAGTVKAAGTVGYLPQNLVLDTAARVDEALGIDGVRRALHAIESGDVAEEHFTAVGDDWDVEERARATLDQLGLAHVGLDRTIGEVSGGESVLLRLAALLMLRPDVLLLDEPTNNLDLKARRRLYAAVESWPGVMVIVSHDRELLDRVDQVADLRDGEVAWYGGNFTAYEEALAVEQEAAERTVRSAEADLRRQKRELAEAHEKLSKRKRYADKQFANKREPKIIMNLRKREAQVSAGKHRIMHEERLRDAKERLDEAEAAVRDDDEIRVDLSYTAVPAGRDVLMLRELELRYGARVPALQVRGPERIALTGRNGAGKSTLLRTIAGQLAPVAGSASVHVPLRYLPQRLDVLDDALSIVENVALLAPAATNQEIRSRLARFLFRQGRADQIVGTLSGGERFRATLAALMLADPAPQLLMLDEPTNNLDMASVRQLVKALESYEGALVVASHDVRFLRDIGITRWLVLDEELSDIEPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NF66</accession>
    <name>A0A0F7NF66_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_27375</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FGGY kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018571.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_27375"/>
    <dbReference type="EnsemblBacteria" id="AKH85337">
        <property type="protein sequence ID" value="AKH85337"/>
        <property type="gene ID" value="AA958_27375"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_27375"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5769"/>
    <dbReference type="OrthoDB" id="1619686at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018483">
        <property type="entry name" value="Carb_kinase_FGGY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00445">
        <property type="entry name" value="FGGY_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FGGY_N" evidence="2">
        <location>
            <begin position="1"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="FGGY_C" evidence="3">
        <location>
            <begin position="256"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH85337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="496" mass="52675" checksum="BA02D83D93E08ADC" modified="2015-07-22" version="1">MIIAHDLGTTGDKASLHADDGTPVAALTEHYGTDFRAGGVAEQDPEVWWRAVCAATRRLLEHTGVRPAEVSAVGFSGQMMGAVLLDSAYRPVRPSLIWADHRSQEQAGRLTAALVAERAYRLLGHQLHPTYSLTKVMWVRDHEPETFARVAHVCLAKDYVVHRLTGVLATDRSDASSTNAYDQPAGSWSAEVLAAAGLDPALFPEIVPSTTVAGPLLPEAAEATGLAAGTPVVLGGGDGPLAALGAGVIDPADGAYTYLGSSSWVSLSAERPLHDPRMRTMTFDHVVPGRYVPTATMQAGGASLDWVAEVLRPGQGGDRFPDLLAAAADADTAGLYFLPHLLGERSPYWNAAAAGAFLGLTRHHQEAHLTRAVLEGVAFNLATCVGAFREAGHPVDRVDAIGGGAASDLWLQILADVWGATVRRRSIVEEANSLGAAVTAGVGAGLVDGFAVARDLSDVTAEFTPDPGRHADYRWRHALFLEAYERLEPWFAKEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFB6</accession>
    <name>A0A0F7NFB6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_31385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020601.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_31385"/>
    <dbReference type="EnsemblBacteria" id="AKH87170">
        <property type="protein sequence ID" value="AKH87170"/>
        <property type="gene ID" value="AA958_31385"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_31385"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6632"/>
    <dbReference type="OrthoDB" id="70058at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032856">
        <property type="entry name" value="GDE_N_bis"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14742">
        <property type="entry name" value="GDE_N_bis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GDE_N_bis" evidence="1">
        <location>
            <begin position="10"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH87170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="662" mass="70536" checksum="E4985F9BE4D67AAD" modified="2015-07-22" version="1">MSDGRVLLARDGTFAALTRGGGVTGRRGTSPDGLFRHDARHLSRWLLTVDGAEPAVLTPARDGSLPAASVLTPPAVRDAPAPYTVFREQAVASGLLLERLRLVSNSPDRVTARLELLVDADFADQFELRSDGRAYARPPEAAREAGERPDGVEFTYRRGEGWLSRTTVTCDPPPDEVTPEDRPGRRAGTARRLGWTLTLPPHGAAELALRVEARPHGAPPVADVATPARAAAEHRAGIEAFTHPPAAADAALLSPAERAALRTACAHGLSDLALLRVPAAGPRGEPLRVPGAGIPWFLTLFGRDSVLTSLFALPYRPALARDTLLALAATQGTRHDAFSAEQPGRIAHEVRHGELAAFRQVPYGRYYGSVDVTPLFLVLLQAHAEATQDTALAARLEPQARAAVEWMLGDGGLAERGWLVYTPDPGGLVNQNWKDSAGAICFADGTQAEGPVAVAEAQGYAYDALVRTARLARGVWGDAPCADRLDALAAGLRDRFHRDFWLPAQDFPALALDGRGRQVDALASDAGHLLWSGILDRERGERTGRRLLAGDFFSGWAVRTLAAGQRPYHPLSYHRGSCWPHDNAVIALGLARYGLGAEVRTLARGLLATAEAHGWRLPEVLAGYARSDHPAPVPYPHACSPQAWAAATPLALLTAVSGGGGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFL5</accession>
    <name>A0A0F7NFL5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Biotin transporter BioY</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_27625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020461.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_27625"/>
    <dbReference type="EnsemblBacteria" id="AKH87066">
        <property type="protein sequence ID" value="AKH87066"/>
        <property type="gene ID" value="AA958_27625"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_27625"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5821"/>
    <dbReference type="OrthoDB" id="318943at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="381"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH87066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="403" mass="41969" checksum="85BFC88937314F41" modified="2015-07-22" version="1">MRTAHTGRHPHTDRATLGELRVSAFKSHRGTRLGLGPVTLLTGGSGSGKTAALEACGVLARLGAGATLEEAFAPVPGGAAACVPQRARPDSAGRRGVRLGCTVRGPLGDVRLDVAVQAEPELRIVGERLTGAGHTLLATALRDPRRDRVQATWHTAGPAPVTRAPLPDDRLGTALLPLRIGGRTDGEQLVLAAAEQAVLALRSVYPCDPHPALMRAATAVPIGGEQLTPDSRNLPAVLRRVRDECSLRHAALVDAVRGGCAGPVHDLTTEEYGDGLVRAVLLREPGRRSTPVETLGDGELRYLALALVLLTGPGVLAVDPASEVLPARQVLTVLADGLDRSMDARQAGELVALSGRMGERGHIRVLGSVGDPSLAQAECATAVPLPQRRERPGPQGEGAKGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NG62</accession>
    <name>A0A0F7NG62_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Streptogrisin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AA958_34010</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019641.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_34010"/>
    <dbReference type="EnsemblBacteria" id="AKH86419">
        <property type="protein sequence ID" value="AKH86419"/>
        <property type="gene ID" value="AA958_34010"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_34010"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.7185"/>
    <dbReference type="OrthoDB" id="1347457at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004236">
        <property type="entry name" value="Pept_S1_alpha_lytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001316">
        <property type="entry name" value="Pept_S1A_streptogrisin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02983">
        <property type="entry name" value="Pro_Al_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001134">
        <property type="entry name" value="Streptogrisin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00861">
        <property type="entry name" value="ALYTICPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002520065" evidence="7">
        <location>
            <begin position="46"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Pro_Al_protease" evidence="8">
        <location>
            <begin position="50"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="264"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="258"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001134-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001134-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH86419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="314" mass="31636" checksum="A2EB372CF3835431" modified="2015-07-22" version="1">MSTERTNPLRRTARRFRRPVTALTALAVLALPAGLGLAGPQAAQAQPRTFSTGELAAAGDAVLAADIAGTAWGVDQATGTVLVTVDERVSAAEIAELRRSAGAQAGALTFERTAGTFRPYLQGGEPVWSTTGRCTAGFNVRVSNADYFVTAGHCTAGFPTWYTNSSRTTLVGPTAASSYPGNDFGIVRYTNPAVPRPGTVNCNGTIIDITGPANLVVGQSVSMAGGATGCHGGGITGINVTVNYGDAIVSGLIRTTLCCGPGDSGSPVFTLTGDGTTALAVGVLSGGSGNCTSGGTSFVQPINEILTAYGAVLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NGA9</accession>
    <name>A0A0F7NGA9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_30235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019015.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_30235"/>
    <dbReference type="EnsemblBacteria" id="AKH85787">
        <property type="protein sequence ID" value="AKH85787"/>
        <property type="gene ID" value="AA958_30235"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_30235"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6388"/>
    <dbReference type="OrthoDB" id="1736098at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13577">
        <property type="entry name" value="SnoaL_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="13"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="151" mass="16385" checksum="999992A171B4AE6E" modified="2015-07-22" version="1">MTSTESPAVLEFLDAAAVAGLVDSYLIGLDTGELDDDWARGLFTEDAAVVFPMSRHEGIRGMAEWHRTSLAAFARTQHLHSPVVTDVRGNVAKLRANLVSTHVHHPGGDRPPLFVTGTGVSGEARRTDDGRWRLTLLEFTVIWLEGTPPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NGF9</accession>
    <name>A0A0F7NGF9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Methylmalonyl-CoA mutase</fullName>
            <ecNumber evidence="10">5.4.99.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AA958_33750</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(R)-methylmalonyl-CoA = succinyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:22888"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:57326"/>
            <dbReference type="EC" id="5.4.99.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Metabolic intermediate metabolism; propanoyl-CoA degradation; succinyl-CoA from propanoyl-CoA: step 3/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Heterodimer of an alpha and a beta chain.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.2" evidence="10"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019595.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_33750"/>
    <dbReference type="EnsemblBacteria" id="AKH86373">
        <property type="protein sequence ID" value="AKH86373"/>
        <property type="gene ID" value="AA958_33750"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_33750"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.7126"/>
    <dbReference type="OrthoDB" id="154460at2"/>
    <dbReference type="UniPathway" id="UPA00945">
        <property type="reaction ID" value="UER00910"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004494">
        <property type="term" value="F:methylmalonyl-CoA mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006159">
        <property type="entry name" value="Acid_CoA_mut_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016176">
        <property type="entry name" value="Cbl-dep_enz_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006099">
        <property type="entry name" value="MeMalonylCoA_mutase_a/b_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006098">
        <property type="entry name" value="MMCoA_mutase_a_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01642">
        <property type="entry name" value="MM_CoA_mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51703">
        <property type="entry name" value="SSF51703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="SSF52242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00640">
        <property type="entry name" value="acid_CoA_mut_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00641">
        <property type="entry name" value="acid_CoA_mut_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00544">
        <property type="entry name" value="METMALONYL_COA_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0846">Cobalamin</keyword>
    <keyword evidence="8" id="KW-0170">Cobalt</keyword>
    <keyword evidence="7 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B12-binding" evidence="9">
        <location>
            <begin position="591"/>
            <end position="723"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AKH86373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="725" mass="78695" checksum="509993011CE15294" modified="2015-07-22" version="1">MTVPDFSDIELGTPAPAAGSDEWRAAVKRGGDGGDLGWETPEGIAVRPLYTGQDLADLDFLDTYPGIAPYLRGPYPTMYVNQPWTIRQYAGFSTAEESNAFYRRNLAAGQKGLSVAFDLPTHRGYDSDHPRVTGDVGMAGVAIDSILDMRRLFDGIPLDRMTVSMTMNGAVLPVLALYIVAAEEQGVPPEKLAGTIQNDILKEFMVRNTYIYPPKPSMRIISDIFAFTSRKMPRYNSISISGYHIQEAGATADLELAYTLADGVEYIRAGREAGLDVDAFAPRLSFFWAIGMNFFMEIAKLRAARLLWAKLVKRFDPQNPKSLSLRTHSQTSGWSLTAQDVYNNVTRTCVEAMAATQGHTQSLHTNALDEALALPTDFSARIARNTQLLLQQESGTTRVIDPWGGSAYVERLTYDLARRAWQHIEEVEQAGGMAQAIDAGIPKLRVEEAAARTQARIDSGRQPVIGVNKYRVASDEQVEVLKVDNSAVRAQQIAKLERLRAERDETACRDALDDLMRAAGGEGNLLELAVRAARARATVGEISYALEKTYGRHAGQIRTISGVYRNEAGESPSVERTRARVGAFAEAEGRRPRILVAKMGQDGHDRGQKVIATAFADLGFDVDVGPLFQTPAEVARQAVEADVHIVGVSSLAAGHLTLVPALREALAEEGRDDIMVVVGGVIPPQDVATLLETGATAVFPPGTVIPDAAYDLVTQLAAGLGHDTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NGS3</accession>
    <name>A0A0F7NGS3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_31115</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019155.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH85927">
        <property type="protein sequence ID" value="AKH85927"/>
        <property type="gene ID" value="AA958_31115"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_31115"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6575"/>
    <dbReference type="OrthoDB" id="504558at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="2">
        <location>
            <begin position="293"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="385"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH85927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="406" mass="43557" checksum="06CC1938835665F2" modified="2015-07-22" version="1">MDEDSVAVVGGSIAGCATAQAVARAGAGRVTVFERAGGELRDRGVGIGLHDARFAELEAAGYVDSSMPWSGLNRRVWTIRDGDAELGHGFAEQHFPFRSYNWGSLWHELRNRVPESVTYHTGAAVTVVEQDADGVTLKLADGRQERFAAVIGADGYRSVVREAMFPGLAPDYAGYLGWRGTSAPVAGDPETDGAEARVVVFPGGHCMMYLIPAAGGGFRMNWVLYAVPPDDPDLLLDLRTPTSLPPGRVAAKLTAYLRDLVAEHFPPYWGRCVLRTAPEDSFIQPIYDLEVPRLAVGRLLLAGDAATVVRPHTGGGSVKALQDATALEAACRAGGDWPEIAAAYDADRTAVGAAMVALGRRLGRAQVEETPDWQKMGQQEFDAWWQEQNQGPDRSSGFGGHALKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NH99</accession>
    <name>A0A0F7NH99_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_16740</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_16740"/>
    <dbReference type="EnsemblBacteria" id="AKH86829">
        <property type="protein sequence ID" value="AKH86829"/>
        <property type="gene ID" value="AA958_16740"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_16740"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3522"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_16" evidence="2">
        <location>
            <begin position="1"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="908"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH86829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="1109" mass="119663" checksum="712CD0AC8A2971E8" modified="2015-07-22" version="1">MLVTGEPGIGKTSLVTAAVAEARRRGTLVLGGSCWASDSAPGYWPWVQVVRGLRRGVPAEEWAAAREAAGSGLDVLLGEEPAAGGRLEHGAPAERVRDDRGPHHEHDRDGAHDRAGAHDRDGAHDRSAAHPHDAARHHDAARGTDPAVVTGPPAGPGTDPAAAGTYADSFHLADAVTTALVAVSHHRPVIVVLDDLHWADPASLRLLEFAAQHTWFERLLLIGTYRDAEVDTPGHPLREQIAPLVAKATTLTLTGLDRAGTARLMARTAGRDPDEALAAEVHRRTGGNPFFIEQTARLWAGGASAEAVAPGVRDALQRRLQLLPAPVAELLVAAAVLGREFHRQVLAAAVGRPPGYVDRLLETAVAARLVVGRGAGLFAFAHDLVRETLYEDLDPAEARRRHAAVVRALDASPALSEKVFPADRARHAWEAGDELPAEQAVGLLRDAGQDAGSRLAFEEVVSHLRRAYERSAAASPRCRVLTALDLGGALLHAGKTADAWPLFEGAVRTAREQDDPEMLARVALGVFSAEGYCATIPQDQAEANRLLLREAHRALARSSHPASAGPDEDELTAGQMAAELSITLSVSARRGQDDEELGFGLWTRHNAIWGLGTAAERVALTEELITLAERAGNPAGRHMAVAMRWVALLELGDPRFAPTYRGYVEAAERSDVPSIRHTLVIDQSLVEALRGDFDAAERHIAQVVEMGRDTEHEHWIEMLDHHWWTIRMLQGRYAEAAEAAGRLTVAGHGFPAGLQALAELRRGDPEPALRLVAEGPPTDEQQNRGFFPLWLRLQAETAAATRDPELAASVRDALSPYRGQWLVAVYGWDVSGPVDYWLALVDAAEGRWAPAAAGFRAARRSADLMQARPWSVLARHGLAGVLREQGDPAAERLARETAAEAARLGMRLEAERPRTPPAEPAAEPPPPAAEFRYDGRVWTLTYAGRTVHLPDAKGLRDLHTLLSAPGTDLPAVRLLNPEGGEELAAAHRLGGDPVLDAEAKSRYRRRLELLDEEIDHATATGDDTRAAAYDRERAALLDELRAAAGLAGRTRRLGDEAERARKAVGARIRDALRKIAKDHPALAEHLKQSLSTGTTCTYHPQNPPPIWRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NHS3</accession>
    <name>A0A0F7NHS3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_23840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86999">
        <property type="protein sequence ID" value="AKH86999"/>
        <property type="gene ID" value="AA958_23840"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_23840"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5024"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH86999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="97" mass="10432" checksum="F5B8D458468837FA" modified="2015-07-22" version="1">MATSTIGFVETVRTLDRMGSFPTAMQDLMRDLTEVLVTEEVRDLAGLLPGRVRTLDAVHVASAQTIGPALDSLISYDKRMLEVAREAGLPTAAPGMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NI75</accession>
    <name>A0A0F7NI75_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Streptogrisin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AA958_30755</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH87154">
        <property type="protein sequence ID" value="AKH87154"/>
        <property type="gene ID" value="AA958_30755"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Pept_S1A_streptogrisin"/>
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        <property type="entry name" value="Peptidase_S1_PA"/>
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        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Trypsin_dom"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ALYTICPTASE"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
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            <end position="296"/>
        </location>
    </feature>
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        <location>
            <begin position="45"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="8">
        <location>
            <begin position="162"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
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        <location>
            <begin position="246"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001134-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001134-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AKH87154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="296" mass="29706" checksum="A21B76D6AB59C751" modified="2015-07-22" version="1">MPRTTPTGASRGRLRFLTATAGLAAVAALALPAGANAQEASPSFSAAELRAVDQAVGDADVAGSAWYVDRASDTVVVTVDSTVSKAEVARITEAAGEHAGAVDINRTEGKFTKYIAGGEAITTGGARCSLGFNVQNSSGTKFALTAGHCTNIGSSWSIGTRSGTSFPTNDYGIIRHSNPAAADGRVYLWNGSYQDITNAANPSVGQSVRRSGSTTGLHGGSVTGLNATVNYGGGDVVYGMIQTNVCAEPGDSGGPLFAGSTALGLTSGGSGNCSSGGTTFYQPVVEALNAYGVSVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NIJ4</accession>
    <name>A0A0F7NIJ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipopolysaccharide biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_07410</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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    </dbReference>
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    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="237"/>
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        </location>
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        <location>
            <begin position="494"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH86592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="559" mass="58582" checksum="B8336B82119924F5" modified="2015-07-22" version="1">MQPQDEPDLLRDQFRQLLRYRGMIVLGVVLGLLGGGWIALASGDEYIASSEVTLRQVSLDPFSSGSDATAIKENIGTERQTAASNAVARIVADEVDHPEDGEKLQHGLQVTNPPNTLVLRFDYSADDPETAAERSNAFAAAYLAYREDKSKRTIDNMVEAYDDQVKPLIAERDALDSEIESLGEGRALESALSARSSLSQSIGQITADRAKLQALDTTPGHVVRDATPPAEPAGPGIFMLLGLGAAFGVGLGLLVAWVRLVFDPTARSESDVVRALHAPVLGTLPRTRRPGGLLATGRVAEEYRSMAFRLAYDQRFADRRRLLVVAPRGSIDIPAAVSVNLAASFVEMGHEVLLVEADLRTPSLSARLSAADGVRPGWARTPARGDGGWPTGLQIPIDAGESGAFDLIPGTRVRNAARALTSAPATQLISEADAPGSVVVVLAPAVLSYADALALADRVDGVLVVCDPRQVHREDLARIRELISGAGGTVLGAVLHSHGSGEPDAGGRGRSGRGAVRGGARGDGRGGEAGAGAGVPAPPAEATGADYPADSRAVRSSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NJK6</accession>
    <name>A0A0F7NJK6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_22420</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86967">
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        <property type="gene ID" value="AA958_22420"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_22420"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4720"/>
    <dbReference type="OrthoDB" id="1437290at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
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        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
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        <property type="entry name" value="MftR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17754">
        <property type="entry name" value="TetR_C_14"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH86967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="184" mass="20976" checksum="6374EFA55A06CC4C" modified="2015-07-22" version="1">MRTRQAIRQAAYRLIGKQGYEQTTVEQIAEAAEVSPSTVFRYFATKEDIILTDEYDPVLEQAILDRPADEPPLVALREAVVASLRLLYDEFRPEFVLRMQLVREVPALRAQMHEGMDQNVELLCRVLSERTGRPRDDFELRVVVGAIFGALTQVLFEWVDRGPEGDLVETVDRALAVLERGMTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MY77</accession>
    <name>A0A0F7MY77_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alpha-L-rhamnosidase</fullName>
            <ecNumber evidence="2">3.2.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AA958_02215</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing alpha-L-rhamnose residues in alpha-L-rhamnosides.</text>
            <dbReference type="EC" id="3.2.1.40"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.2.1.40" evidence="2"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014544.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_02215"/>
    <dbReference type="EnsemblBacteria" id="AKH81180">
        <property type="protein sequence ID" value="AKH81180"/>
        <property type="gene ID" value="AA958_02215"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_02215"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.476"/>
    <dbReference type="OrthoDB" id="170130at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030596">
        <property type="term" value="F:alpha-L-rhamnosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016007">
        <property type="entry name" value="Alpha_rhamnosid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035396">
        <property type="entry name" value="Bac_rhamnosid6H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035398">
        <property type="entry name" value="Bac_rhamnosid_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013737">
        <property type="entry name" value="Bac_rhamnosid_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008902">
        <property type="entry name" value="Rhamnosid_concanavalin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05592">
        <property type="entry name" value="Bac_rhamnosid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17389">
        <property type="entry name" value="Bac_rhamnosid6H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17390">
        <property type="entry name" value="Bac_rhamnosid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08531">
        <property type="entry name" value="Bac_rhamnosid_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010631">
        <property type="entry name" value="A-rhamnsds"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519576" description="Alpha-L-rhamnosidase" evidence="4">
        <location>
            <begin position="29"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_rhamnosid_N" evidence="6">
        <location>
            <begin position="345"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_rhamnosid" evidence="5">
        <location>
            <begin position="524"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_rhamnosid6H" evidence="7">
        <location>
            <begin position="629"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_rhamnosid_C" evidence="8">
        <location>
            <begin position="963"/>
            <end position="1035"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH81180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="1061" mass="114715" checksum="22884458EBC9B452" modified="2015-07-22" version="1">MISRRRLLGTATALGTAAATGATPAARAATVAGSDAVREAEVTRPTVEYAGRPLGLDVDRPRLSWPVESGAPGGTQSAYRIKVATAEQKLSDPDVWDSGKVESGDSVLVPYGGPELRPRTRYHWTVRVWDQDGTASDWSEPTWWETGLRGEDWDASWIAAPGLPADAPDITGSSWIWFPEGDPASSAPAETRWFRARLAVPEGVTRARLAVAADDRHTTYVDGTEVSSGTAWNRPDVVDVTGLLTAGTAVIAVSATNGAVGPAGLLGALELTTADGVTTLVTDGDWKSADAEPAAGWTAPDFDDSGWEAAKVLAPWGAGPWGEVAVPVSLPAARLRHEFRLPTRRIVRARLYATALGLYEAHLNGHRVGEDVLAPGWTDYHKRVQYQTYDVTSLLRPGANAIGVDLAAGWYAGNLGWFGPHHYGERPALLAQLEVTYADGGVERILSDTGWRGAGGPVTAADLMAGEDHDARLETPGWTSPGFDDSGWRPAEAADGGGTAIVAQVDAPTRVESELPARTVTEPAPGVFVFDLGQNMVGAVRLRVKGRAGTVVTLRHAEVLNPDGTLYTANLRTARATDTYTLSGADGGEVYEPKFTFHGFRYVEVTGYPGRPEKTAVTGRVMHTAAPFTMEFETNVPTLNRLHSNITWGQRGNFLSVPTDTPARDERLGWTGDINVFAPTAAYTMESARFLTKWLYDLRDDQDDDGAYPDVAPWVGPVGKGVAGWGDAGTTVPWALYQAYGDTRVLEQSWSSMLEWLEYLKRNSNGYLRPAAGYGDWLNTQDETPKDVIGTAYFAHSADLVARIARVLGRDPAPYDTLFRAVREAFTAAYVSEGGARIKGDTQTAYVLALSMDLLPEDARKPAADRLVALVGARDWHLSTGFLGTPRLLPVLTATGHTDVAYRLLHQDTFPGWGYQIANGATTMWERWDSIKPDGSFQDAGMNSFNHYAYGCVGEWMYRHITGIAPAEPGFRKLLIRPRPGGEVDRARGRLSTLYGPVTTDWQVRDGRLRLDVTLPFNTTAEVWVPARAAADVSHGRARFLRTEDGCAVFAADAGTHRFAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MYN5</accession>
    <name>A0A0F7MYN5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_03120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014695.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_03120"/>
    <dbReference type="EnsemblBacteria" id="AKH81335">
        <property type="protein sequence ID" value="AKH81335"/>
        <property type="gene ID" value="AA958_03120"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_03120"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.665"/>
    <dbReference type="OrthoDB" id="1835805at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH81335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="201" mass="21556" checksum="D68A93966C6DC65E" modified="2015-07-22" version="1">MRLATLLAEEPRSQPVTDWAARIGWVVGLILFIALVYWLMREGWKWRGQLQSGIPDLPAIPEETGEVRLELTGRYHGTTAAGQWLDRIVAHGLGVRSRVELTLTEQGLAVVRPGAADFFVPAAHLRGARLDKAIAGKVLTEGGLLVVTWAHGGAEYDSGFRSDHAAEHAAWVAALGARTTENAPADAAASTADSTTTEGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MYW2</accession>
    <name>A0A0F7MYW2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_03725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014803.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH81445">
        <property type="protein sequence ID" value="AKH81445"/>
        <property type="gene ID" value="AA958_03725"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_03725"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.784"/>
    <dbReference type="OrthoDB" id="2145143at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="366" mass="39454" checksum="6CD3F8A217C8EDD5" modified="2015-07-22" version="1">MIPWYRQLWHFVTSREGFGAITVATSFGVAVGVVPSILQELSGDLWVFVVVFVAAVAAVVGGWALGRPRGVGVVACLYPQPDRDRLRRLEDASDGNHSSSQRLHPDLLSLGGVTLDPAARVDLAAKLISARIAEHQANDPDGSVTLYPLAPLDDGYLLGRRLRDTRFHALHVMHVPSVGSEKAVHTITLGPHLEDPLTEAQHRLVSRHMVTPAGTATSAPAPVANPDCPARYRHRLALIVRITPSTSMVADARFVATTGEVQRSADHPHTGYVPSDSHPCGAHAVIEAAGPLTESREVFEAVSAHIHQSWQTARATWAEETGQPGITTRLFISAPLPIVLALGWLLAREDVTLVPHRLHLSERGGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MZU2</accession>
    <name>A0A0F7MZU2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Xylulose kinase</fullName>
            <shortName evidence="3 5">Xylulokinase</shortName>
            <ecNumber evidence="3 5">2.7.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">xylB</name>
        <name evidence="8" type="ORF">AA958_02450</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the phosphorylation of D-xylulose to D-xylulose 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 5">
            <text>ATP + D-xylulose = ADP + D-xylulose 5-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10964"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17140"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.17"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the FGGY kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.17" evidence="3 5"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014584.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_02450"/>
    <dbReference type="EnsemblBacteria" id="AKH81221">
        <property type="protein sequence ID" value="AKH81221"/>
        <property type="gene ID" value="AA958_02450"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_02450"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.524"/>
    <dbReference type="OrthoDB" id="1619686at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004856">
        <property type="term" value="F:xylulokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005998">
        <property type="term" value="P:xylulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02220">
        <property type="entry name" value="XylB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018483">
        <property type="entry name" value="Carb_kinase_FGGY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006000">
        <property type="entry name" value="Xylulokinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01312">
        <property type="entry name" value="XylB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00933">
        <property type="entry name" value="FGGY_KINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00445">
        <property type="entry name" value="FGGY_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 3 5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="1 3 5" id="KW-0859">Xylose metabolism</keyword>
    <feature type="domain" description="FGGY_N" evidence="6">
        <location>
            <begin position="5"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="FGGY_C" evidence="7">
        <location>
            <begin position="251"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="77"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="234"/>
        </location>
    </feature>
    <feature type="site" description="Important for activity" evidence="3">
        <location>
            <position position="9"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH81221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="473" mass="48719" checksum="59E06E2F2D75C9BE" modified="2015-07-22" version="1">MGPLVIGVDSSTQSTKALVVDSETGQVVAHGQAAHVVSTGGRRESDPEQWWDALGAALAACGPPAREAAAISVGAQQHGLVTLDAGGRPVRPALLWNDVRSAAQRDRLVTELGGPKGWAERTGSVPAASFTVTKWAWLAEQEPESAAATAAVRLPHDYLTERLTGEAVTDRGDASGTGWWDAATEAYDSATLEHVGLSPDRLPRVVRPGGAAGTVHAEGLPVPRGALVAPGTGDNMAAALGLGLAAGQPVLSLGTSGTVYAVSRHRPADPTGTVAGFADARGDWLPLACTLNCTQAVDRIAALLSRYREEVQPGGTAVVLPFLDGERTPDLPHASGLVHGLRHDTTPGQVLQAAYDGAVHALLTALAEVSGPDADPDAPLLLIGGGAQGAAWRETVRRLSGRAVQVPRAQELVALGAAAQAAGLLLDEDPAAVARRWSTAEGRTYEPLERDDATLERIGAVLADAGALLRRAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N039</accession>
    <name>A0A0F7N039_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HEPN_SAV_6107 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_06605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_06605"/>
    <dbReference type="EnsemblBacteria" id="AKH81935">
        <property type="protein sequence ID" value="AKH81935"/>
        <property type="gene ID" value="AA958_06605"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_06605"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1378"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040891">
        <property type="entry name" value="HEPN_SAV_6107"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18726">
        <property type="entry name" value="HEPN_SAV_6107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HEPN_SAV_6107" evidence="1">
        <location>
            <begin position="40"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="158" mass="17005" checksum="6C74D241B8B4C2E5" modified="2015-07-22" version="1">MAAEPAYAPPSDVHPVLRPGSAPKAALELLAQAHAGLAEAAEMETANERYSLAHLAALRTAAAVLAVRGRPEPTPRRRQRIRSAWEVLPEVAPELAEWSAMFAAGARLRARAEAGIRDAVDAEEAADLLRAAGMFTRIVERMLVVQPLIRPQPGPEPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0H4</accession>
    <name>A0A0F7N0H4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cyclodipeptide synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_00575</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDPS family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH80908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH80908">
        <property type="protein sequence ID" value="AKH80908"/>
        <property type="gene ID" value="AA958_00575"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_00575"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.135"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016755">
        <property type="term" value="F:aminoacyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030903">
        <property type="entry name" value="CDPS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038622">
        <property type="entry name" value="CDPS_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16715">
        <property type="entry name" value="CDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04539">
        <property type="entry name" value="tRNA_cyclodipep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00030771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH80908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="240" mass="25839" checksum="9A44D948529108E4" modified="2015-07-22" version="1">MEFTDTPLTPNCARVFESGVHVVVGVSLGNSYFNGDVLRGLLRWLHARFETIDVVVPDSSYHDNLLVAGHPAAYAKRKTTRETATARSRILRSWQQAGIGASGAEHVHPLSALAGDAVYRSLRAQVVRGLAEDAELRRCCLEMSASALRSQLRGAEPSPGQVEAGLGYLEAELPFFLGSADVFGVASSVCFYHRPIPAAELLFSRGGSLHPPPSQGYALIRPAHEARPVPAEGEMQGVRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0I1</accession>
    <name>A0A0F7N0I1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_00210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH80849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014216.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH80849">
        <property type="protein sequence ID" value="AKH80849"/>
        <property type="gene ID" value="AA958_00210"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_00210"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.48"/>
    <dbReference type="OrthoDB" id="2092457at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH80849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="92" mass="10208" checksum="86372FFA7D8F894B" modified="2015-07-22" version="1">MTTVKSTDFAHTEAGKMLSLINNQLPQLIQQLNGHGQQLSDPNHWDGPLAQRFRGEVWPQAKTDLDRMKASLEQLQQQVQKILTSISNAGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0M3</accession>
    <name>A0A0F7N0M3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Antitoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_00880</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Antitoxin component of a type II toxin-antitoxin (TA) system.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the phD/YefM antitoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH80958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014324.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_00880"/>
    <dbReference type="EnsemblBacteria" id="AKH80958">
        <property type="protein sequence ID" value="AKH80958"/>
        <property type="gene ID" value="AA958_00880"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_00880"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.196"/>
    <dbReference type="OrthoDB" id="2047723at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006442">
        <property type="entry name" value="Antitoxin_Phd/YefM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036165">
        <property type="entry name" value="YefM-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02604">
        <property type="entry name" value="PhdYeFM_antitox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143120">
        <property type="entry name" value="SSF143120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="70"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH80958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="102" mass="10734" checksum="D49ECB99572D366F" modified="2015-07-22" version="1">MAYEIPVTQARAELADLINRVVYGGERVVVTRHGRPLVALVSAADLEKLDELENPPAEEQVITTVSGVHTAHPAGSATGERRFGIAAEHRAPGTRASGEGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0X1</accession>
    <name>A0A0F7N0X1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome segregation protein ScpA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_04925</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015001.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_04925"/>
    <dbReference type="EnsemblBacteria" id="AKH81646">
        <property type="protein sequence ID" value="AKH81646"/>
        <property type="gene ID" value="AA958_04925"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_04925"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1036"/>
    <dbReference type="OrthoDB" id="959677at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003768">
        <property type="entry name" value="ScpA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33969">
        <property type="entry name" value="PTHR33969"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02616">
        <property type="entry name" value="SMC_ScpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="416"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="43"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH81646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="438" mass="47216" checksum="6942E5507D4B9492" modified="2015-07-22" version="1">MDDRHDDPQRPARTARRSLGRGPGVAATPTKPAPRPVEPDPVREPYPEPMPLPQPEPAPVPGPPVPIPGPAPRPDEPGPAPGRPDPEPETEPAPVGPGGADPAEEPAPEPGRDPEPETDREPAPGPVPEPDSAPEPAAQSRPATGPGNAPEPGAEPGGDDPDDGAFRVRLANFEGPFDLLLQLISKHKLDVTEVSLHRVTDDFMAHIRAMGPDWDLDQTTEFLVVAATLLDLKAARLLPAAEVEDEEDLALLEARDLLFARLLQYRAYKEIAGIFHRRLEEESLLHPRTVGLEPHHAELLPEVVISIGPEGFARLAVKAMQPKPVPQVYVDHIHAPLVSVQEQAQVVVSRLREHGSVSFQELIADAPDPLTVVARFLALLELYRERAVALDQEGALEPLTVRWTGREDVVPVVTDEFDTAPGDADAAGGNQGEGEDER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N121</accession>
    <name>A0A0F7N121_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_08805</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015657.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_08805"/>
    <dbReference type="EnsemblBacteria" id="AKH82310">
        <property type="protein sequence ID" value="AKH82310"/>
        <property type="gene ID" value="AA958_08805"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_08805"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1855"/>
    <dbReference type="OrthoDB" id="1510342at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="34"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="222"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="267"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="97"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH82310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="303" mass="32991" checksum="E8AEF873E2C208B2" modified="2015-07-22" version="1">MSQATTSRPTRSAASRPPRPAASRPRRRGERSTAASVALHGTLLLASFVALFPVAWLAWISLGPDKTDFLHAGEIAGKVSLSNYTTVLSDTDFLHWVGNSLIVSLGTCVIGVFVSASAAYAVSRMRFPGHRQLMWTFLVTQMFPFAILIVPLYNILAGLDLLDTYWALIAVNLTQAVPYCAWLLKGYFDTIPHEIDEAGRVDGLTPFGTFWRLVLPLARPGMAVAAFYTFITAWAEFAFASVFLLSSDKYTLPIGLATFVSEHDQQWNLMAATGVLIGLPAAAFFYLVQRHLVTGLTAGAAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N1D0</accession>
    <name>A0A0F7N1D0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LacI family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_02495</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014591.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_02495"/>
    <dbReference type="EnsemblBacteria" id="AKH81228">
        <property type="protein sequence ID" value="AKH81228"/>
        <property type="gene ID" value="AA958_02495"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_02495"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.534"/>
    <dbReference type="OrthoDB" id="1796334at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001761">
        <property type="entry name" value="Peripla_BP/Lac1_sug-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00532">
        <property type="entry name" value="Peripla_BP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="16"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH81228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="353" mass="36427" checksum="9BE3B0054BBDBFF6" modified="2015-07-22" version="1">MTPGPAGGAAPRDAQPTLRDVAERAAVSAMTVSRVLRDDPKVLPATAARVRAAVAELGYRRNEVARSLRLGSGTGLVGLVVTNLANPFYSRLALGVDAVVAQHGLKAVIGNTGQDIDTERSLVEDLVARRVDGIVAVPAGGDQRHLAAAAAEGVPVVLASRPPVGFAADHVLVDDYGGARAATERLLAAGHRRIGFLGTPPAVYTGTERLRGYTAALADAGLPADGTYIRQGQQQTAEAAVATAALLALPEPPTALFCSNNRNTIGAFRAIREAGTATALAGFDDFEMADTLGLPLTLVAYDTDELGREAGRLLLARLGERAGAGPRVDAAPTPPERRTMVPTTLVSYGTPGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N1N3</accession>
    <name>A0A0F7N1N3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NAD_synthase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_02865</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014652.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_02865"/>
    <dbReference type="EnsemblBacteria" id="AKH81289">
        <property type="protein sequence ID" value="AKH81289"/>
        <property type="gene ID" value="AA958_02865"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_02865"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.613"/>
    <dbReference type="OrthoDB" id="846643at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016783">
        <property type="term" value="F:sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005232">
        <property type="entry name" value="LarE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43169:SF2">
        <property type="entry name" value="PTHR43169:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_synthase" evidence="2">
        <location>
            <begin position="61"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH81289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="332" mass="33470" checksum="D77A3398433AACB3" modified="2015-07-22" version="1">MTDAGPAAHHGPAADRRGPTATAAGDPAAVPAPGAAAADSGEPDAGAAAAALLAEVGRLGSVAVAYSGGVDSTVVLAAAVRALGPGRAVAVIADSPALARGELALARETAADLGAELVVLDTDELSVAGYRANAGDRCYFCKQTVLGRVSGYAAEHGFAHVATGTHLDDRRAAHRPGLRAAKELAAAEPLAAAGLGKAAVRAVARAWGLPVAEKPGMPCLASRIAVGITVSKDRLHLVERAEERVRETLDEHRVGARDVRVRLLKQGFRIELDAPAHREVAAAHGLGDTLLREVAAVGPLGEGSLAPYRTGAVSTAARAASRTVSSDGAPTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N1N7</accession>
    <name>A0A0F7N1N7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">von Willebrand factor A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_09895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015837.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_09895"/>
    <dbReference type="EnsemblBacteria" id="AKH82495">
        <property type="protein sequence ID" value="AKH82495"/>
        <property type="gene ID" value="AA958_09895"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_09895"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="VWF_A"/>
    </dbReference>
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        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18571">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="1">
        <location>
            <begin position="66"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="451" mass="47137" checksum="E20FC2A8FEF90F67" modified="2015-07-22" version="1">MANFSKSNAPEFSVEVYQNEYLPEDGREVNAIVTVASTGGGTTGGMPLPAADPGRMQFGSAGPDAGVVIMVDCSGSMDYPPTKMRNARDATAAAIETVRDGVAFAVVAGTHVAREVYPGGGRLAVADPATRTEAKEALRKLSAGGGTAIGTWLRLADKLLGSSEVAIRHGILLTDGRNEHESPEDLRAALDACAGRFTCDARGVGTDWEVKEVTGIASALLGTADIVADPAGLAADFTQMMETAMGKEVADVALRLWTPQGSVIKFVKQVAPTVEELTERRTEAGPRAGDYPTGSWGDESRDYHVCVEVPPASVGQEMLAARVSLILPRPDGSAQTLSQGLIRAVWTDDMAASTRINAQVAHYTGQAELAQVIQAGLEDRKAGDMDGATAKLGRAVQLASASGNADTAKLLSKVVDVVDAASGTVRLKAKVAEADEMTLETRSTKTVRVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N227</accession>
    <name>A0A0F7N227_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_10930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015995.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_10930"/>
    <dbReference type="EnsemblBacteria" id="AKH82655">
        <property type="protein sequence ID" value="AKH82655"/>
        <property type="gene ID" value="AA958_10930"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_10930"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2299"/>
    <dbReference type="OrthoDB" id="1017413at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036683">
        <property type="entry name" value="CO_DH_flav_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002346">
        <property type="entry name" value="Mopterin_DH_FAD-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00941">
        <property type="entry name" value="FAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55447">
        <property type="entry name" value="SSF55447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="1">
        <location>
            <begin position="5"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="298" mass="30254" checksum="C8BD4436EA9A1F47" modified="2015-07-22" version="1">MTTHAPQAAPTVVLPDSLDEAVAALVAMPAAVPVAGGTDLMAAVNAGLLRPSALVGLGRISELRGWQYQDGAALLGSGLTHARIGRPDFAALIPALAAAARAAGPPQVRNAATLGGNIASADRTGDTLPVLAALDATVVIAEPGGGHREIPVSHLLAGVEMLRTGELIAFVRAPLLHAPQVFLKATGRTGPGRAVASVALVLDPARRSVRCAVGAVAPAPLRPMEAEQWVAGLMDWDGHRGLPPEALAAFGEYVAAACIPDPPPGAEGEEPPRLPAAALHLRRTVSALARRALGRALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2B1</accession>
    <name>A0A0F7N2B1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_07755</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015496.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_07755"/>
    <dbReference type="EnsemblBacteria" id="AKH82146">
        <property type="protein sequence ID" value="AKH82146"/>
        <property type="gene ID" value="AA958_07755"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_07755"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1631"/>
    <dbReference type="OrthoDB" id="1309950at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041642">
        <property type="entry name" value="KstR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17925">
        <property type="entry name" value="TetR_C_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="17"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH82146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="208" mass="22832" checksum="C0DDFF61662F0F04" modified="2015-07-22" version="1">MTTTSRAGRAQLTERQEARRRRILQATAELAGRGGFDAVQMREVAERAGVALGTLYRYFPSKVHLLVATLQDQLRQLHETLRKRPPTATEPGARVAQTLLRAFRALQREPQLADAMVRALIFADRSASPEVEVASRLTSAIILDAMGAEGRPAPEQLSVARVIEHTWHAALITWLSGRASSAQVRTDIETVCRLVDGTGTDARAGWVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2G4</accession>
    <name>A0A0F7N2G4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha-sialidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_04495</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014928.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_04495"/>
    <dbReference type="EnsemblBacteria" id="AKH81573">
        <property type="protein sequence ID" value="AKH81573"/>
        <property type="gene ID" value="AA958_04495"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_04495"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.948"/>
    <dbReference type="OrthoDB" id="1293876at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004308">
        <property type="term" value="F:exo-alpha-sialidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011040">
        <property type="entry name" value="Sialidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026856">
        <property type="entry name" value="Sialidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10628">
        <property type="entry name" value="PTHR10628"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13088">
        <property type="entry name" value="BNR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50939">
        <property type="entry name" value="SSF50939"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519711" evidence="1">
        <location>
            <begin position="29"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="Sialidase" evidence="2">
        <location>
            <begin position="67"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH81573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="407" mass="43051" checksum="D71A52FBD6AE94EA" modified="2015-07-22" version="1">MRTSTSLLFLSATALLGTLAAGPGTAAADAGATASGQARCTSSVPYRSGEGGYDTYRIPATVKTRGGSLLAFAEGRVGGAGDTGNIDVVVRRSEDGGCTWGPMSVVAAGGGDTRGNPAPVVDPETGDLVLVTSYNSGKVTEAQIMRGEVTAEQSRRVFVQRSTDDGRTFDAPREITADVKLPQWRWYATGPGHAVALKQGPNRGRLVIPSNHSTAPPAGSADTGQEARYYGAHAIYSDDGGRSWKMGFVDDEYEGEINSNENIAAELPDGRLYFSTRDQNGTSPGNRLDAYSSDGGATLDRPYRVQPDLDEVPVVQASVLQPVGRHAPLLFSGPSNPAKREKLAVWRSDDAGRNFTKVTTLSQQPAAYSDLVQVNGQTIGVLYETGAAGSYETIEFRRLDLRNLGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2T2</accession>
    <name>A0A0F7N2T2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Xylose isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_08900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015673.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_08900"/>
    <dbReference type="EnsemblBacteria" id="AKH82326">
        <property type="protein sequence ID" value="AKH82326"/>
        <property type="gene ID" value="AA958_08900"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_08900"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1874"/>
    <dbReference type="OrthoDB" id="1007505at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="26"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="285" mass="30817" checksum="10A5EBB61E11A06D" modified="2015-07-22" version="1">MPADTLPLCGIGDEAGTPAAVQTGALNELGWPLIELRSVDGVALADLDDTAFAELAGSVRAAGLGVHCVDSRIANWARPVTGDFDEDLHELDILAERCATLGTRYVRVMSYPNDGLSPGAWRAVVLRRMAILTERAERAGLVLLHENCAGWAGASADRMLQLLRYVDSPALRLVFDTGNGPAYGYRAYDLLPQLTPWIEHVQIKDAVVEGDEIRYTLPGHGECRVLDCLRHLIDRGYTGALSIEPHVKVRPHESATAGDDETRAAFVACGRALEELLARIGKVTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-10-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N338</accession>
    <name>A0A0F7N338_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_13400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016391.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH83060">
        <property type="protein sequence ID" value="AKH83060"/>
        <property type="gene ID" value="AA958_13400"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_13400"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2818"/>
    <dbReference type="OrthoDB" id="1832218at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519070" evidence="1">
        <location>
            <begin position="33"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="Amidohydro-rel" evidence="2">
        <location>
            <begin position="120"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH83060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="362" mass="40615" checksum="C93AFF32FAD295A3" modified="2015-07-22" version="1">MPYVSRRTAVTATTWLAAVVVLGPTAGSAASAAGEDCFDRRTQPYTSVVDGHLHFRPFGGEAVPFREVVGYLKRTGVRHAGVFGIGQKLPVDSPCTYYLDCPGTPVLPSIKNDFVNAENVVEHKQEDVDLALSMTYPDLAHPETVVGGMRQLDREFPGMFQWMGEVNLIKQALLPNKHEPADEADITGWAPFMAELRRRDMPITIHSDLGNDRDPTRYLHLMERVLRLYPHNKIVWAHMGLSKELSAMDPDEHVALMARLLERHPNLTLDLSWRVLEDMYFGKPGVRAKYAALFDAYPEQAIPGTDFVASRDKSFGVYKEELEVTSRINKAMGDEAFRRIALGQNYFDLLGIKERAPEICEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N362</accession>
    <name>A0A0F7N362_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_05970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015177.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_05970"/>
    <dbReference type="EnsemblBacteria" id="AKH81824">
        <property type="protein sequence ID" value="AKH81824"/>
        <property type="gene ID" value="AA958_05970"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_05970"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1248"/>
    <dbReference type="OrthoDB" id="1818432at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="207" mass="21532" checksum="A5D61D60072B2EF5" modified="2015-07-22" version="1">MSAPTRPEPGPEPDPGPPAEILGGGSAGPRLGERWTALPPRFRRLAAAGAGLAVLAAAGGYALATRPEPEPPAPVPYPLQSTHFSFLGIETPKAGDNVFDAQLMATSESGASLEKITQGYSGLRLSVRPALPLDLAEGQPTRVTVRFEVVRCAGLPLDASLPSLRVTLRNMRAIQDYSSILGGTYAAELSRALRTICEPASRAAPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N378</accession>
    <name>A0A0F7N378_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">30S ribosomal protein S1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rpsA</name>
        <name evidence="3" type="ORF">AA958_05910</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015166.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_05910"/>
    <dbReference type="EnsemblBacteria" id="AKH81813">
        <property type="protein sequence ID" value="AKH81813"/>
        <property type="gene ID" value="AA958_05910"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_05910"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1237"/>
    <dbReference type="OrthoDB" id="1235756at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035104">
        <property type="entry name" value="Ribosomal_protein_S1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10724:SF7">
        <property type="entry name" value="PTHR10724:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00681">
        <property type="entry name" value="RIBOSOMALS1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="S1 motif" evidence="2">
        <location>
            <begin position="40"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="2">
        <location>
            <begin position="127"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="2">
        <location>
            <begin position="213"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="2">
        <location>
            <begin position="298"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="438"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH81813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="497" mass="54641" checksum="11A7DFB477892A0F" modified="2015-07-22" version="1">MTSSTENTAAATTQVAVNDIGSEEAFLAAIDETIKYFNDGDIVDGVIVKVDRDEVLLDIGYKTEGVIPSRELSIKHDVDPNEVVAVGDEIEALVLQKEDKEGRLILSKKRAQYERAWGTIEKIKEEDGIVTGTVIEVVKGGLILDIGLRGFLPASLVEMRRVRDLQPYVGKELEAKIIELDKNRNNVVLSRRAWLEQTQSEVRQTFLTTLQKGQVRSGVVSSIVNFGAFVDLGGVDGLVHVSELSWKHIDHPSEVVEVGQEVTVEVLDVDMDRERVSLSLKATQEDPWQQFARTHQIGQVVPGKVTKLVPFGAFVRVDEGIEGLVHISELAERHVEIPEQVVQVGDEIFVKVIDIDLERRRISLSLKQANETFGPDPMAVDFDPTLYGMAASYDDQGNYIYPEGFDPETNEWLDGYEKQREEWEGQYAEAHARFEQHQAQVVKSREADAQAAAEAGDSAPAPSGGGSYSSEGADDSGALASDEALAALREKLAGGQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3F4</accession>
    <name>A0A0F7N3F4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">K(+)-insensitive pyrophosphate-energized proton pump</fullName>
            <ecNumber evidence="9">7.1.3.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Membrane-bound proton-translocating pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Pyrophosphate-energized inorganic pyrophosphatase</fullName>
            <shortName evidence="9">H(+)-PPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">hppA</name>
        <name evidence="11" type="ORF">AA958_14310</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>diphosphate + H(+)(in) + H2O = 2 H(+)(out) + 2 phosphate</text>
            <dbReference type="Rhea" id="RHEA:13973"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="EC" id="7.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-insensitive subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="7.1.3.1" evidence="9"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016527.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_14310"/>
    <dbReference type="EnsemblBacteria" id="AKH83210">
        <property type="protein sequence ID" value="AKH83210"/>
        <property type="gene ID" value="AA958_14310"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_14310"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3012"/>
    <dbReference type="OrthoDB" id="98036at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009678">
        <property type="term" value="F:pyrophosphate hydrolysis-driven proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01129">
        <property type="entry name" value="PPase_energized_pump"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PPase-energised_H-pump"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31998">
        <property type="entry name" value="PTHR31998"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="H_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001265">
        <property type="entry name" value="H+-PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01104">
        <property type="entry name" value="V_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="195"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
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            <begin position="265"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
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            <begin position="289"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="322"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
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            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
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            <begin position="413"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
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            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
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            <end position="532"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
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    <feature type="transmembrane region" description="Helical" evidence="9">
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            <end position="766"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="775"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
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        </location>
    </feature>
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        <location>
            <position position="510"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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        <source>
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            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01129"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
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        <source>
            <dbReference type="EMBL" id="AKH83210.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="800" mass="81103" checksum="1D145DB215192C8A" modified="2015-07-22" version="1">MAGHFTPLQQDHLLAVELTSGNRAIVAIIAVVALAALAVAVVLLRQVLAAGEGTDNMKKIAAAVQEGANAYLARQLRTIGIFAVVVFFLLFLLPADDWSERAGRSIFFLVGAAFSAATGYIGMWLAVRSNVRVAAAARAATPREGEPAKDLTAVSHEATKLAFRTGGVVGMFTVGLGLLGACSVVLVYAADAPKVLEGFGLGAALIAMFMRVGGGIFTKAADVGADLVGKVEQGIPEDDPRNAATIADNVGDNVGDCAGMAADLFESYAVTLVAALILGKVALGDAGLAFPLIVPAIGVVTAMIGVFVVAPKASDRSGMTAINRGFFISAVISLVMVAIAVFAYLPSSYADLDGVGAGIAEHDGNPQVLALVAVAIGIVLAAVIQQLTGYFTETNRRPVRDIGKTSLTGPATVVLSGISIGLESAVYTAVLIGLSVYGAFLLGGTSIMLALFAVALAGTGLLTTVGVIVAMDTFGPVSDNAQGIAEMSGDVEGDGAQVLTNLDAVGNTTKAITKGIAIATAVLAAAALFGSYRDAVNEAVSEATNVGNPLALSLDIGQPNNLVGLILGAAVVFLFSGLAINAVSRSAGAVVFEVRRQFRERPGIMDYSEEPEYGKVVDICTRDALRELRTPGLLAVMAPIAVGFTLGVGALASFLAGAIGAGVLMAVFLANSGGAWDNAKKLVEDGNHGGKGSEAHAATVIGDTVGDPFKDTAGPAINPLLKVMNLVALLIAPAVVKFSYGDDANPAVRAVIAVAAIGIIAGAVYISKRRGIAVGDEESETTAPTGPPPTSQTDPAVVNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3F5</accession>
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        <submittedName>
            <fullName evidence="2">Sugar-binding protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">AA958_10455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519739" evidence="1">
        <location>
            <begin position="29"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="441" mass="47273" checksum="F9167ABD36F0152B" modified="2015-07-22" version="1">MRSYRTTRRAVGLLAAAALGTGLLSACASDDEDGGSKAGSEDGGGGKTTITMGLFGTFGFKEAGLYDEYEKLNPDITIKETVIERNENYYPQLLNHLTSNSGLADVQAIEVANIAEVVDTQSDRFVDLGKVDGASKDAFLDWKWQQATADDGKTIGLGTDVGPMAVCYRKDHFKAAGLPTDRDEVAKLWAGDWEKFLDAGRDFKENGPEGVAWVDSADAVYDGAIASSEGKYYDESGEVIYKDSQDVKDAWGIAATAAEEKLTGNLEQFTKQWDQAMSNGDFATISCPAWMLGYIQEKGGTKAEGKWDVAQSPKPGNWGGAFLGVPESGPNKDEAAKLVAWLTAPEQQAKLFAERGNFPSAPPAYDMEAVKTATNPYFGDAPIGELFSASAQEIPVQTIGPKDQVIDDNIGNGLQLIEQGKQDPDGAWDEAVKAVDNALDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3F7</accession>
    <name>A0A0F7N3F7_9ACTN</name>
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        <submittedName>
            <fullName evidence="1">Growth inhibitor PemK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_06270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81878.1"/>
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    </dbReference>
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    </dbReference>
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    <dbReference type="PATRIC" id="fig|444103.5.peg.1311"/>
    <dbReference type="OrthoDB" id="1754531at2"/>
    <dbReference type="Proteomes" id="UP000034283">
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003477">
        <property type="entry name" value="PemK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011067">
        <property type="entry name" value="Plasmid_toxin/cell-grow_inhib"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02452">
        <property type="entry name" value="PemK_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH81878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="134" mass="14442" checksum="1315EDEA5B88323C" modified="2015-07-22" version="1">MQRGEVWWVEFDERRPVVLLSGDDASGIRVMQVVAPAGVDITGLGVEVAVGAVEGLPFEGVLRFALPRPGFTPCTWLTTVSRDDLIERAGVLSPAKLSEMENALRLGEQAKEWTPATTAKLSELRNALRLGGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3I4</accession>
    <name>A0A0F7N3I4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Probable endonuclease 4</fullName>
            <ecNumber evidence="7">3.1.21.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Endodeoxyribonuclease IV</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Endonuclease IV</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">nfo</name>
        <name evidence="10" type="ORF">AA958_06660</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>Endonucleolytic cleavage to 5'-phosphooligonucleotide end-products.</text>
            <dbReference type="EC" id="3.1.21.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 3 Zn(2+) ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the AP endonuclease 2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.21.2" evidence="7"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015296.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_06660"/>
    <dbReference type="EnsemblBacteria" id="AKH81944">
        <property type="protein sequence ID" value="AKH81944"/>
        <property type="gene ID" value="AA958_06660"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_06660"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1389"/>
    <dbReference type="OrthoDB" id="1088517at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008833">
        <property type="term" value="F:deoxyribonuclease IV (phage-T4-induced) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00019">
        <property type="entry name" value="AP2Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00152">
        <property type="entry name" value="Nfo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001719">
        <property type="entry name" value="AP_endonuc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018246">
        <property type="entry name" value="AP_endonuc_F2_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21445">
        <property type="entry name" value="PTHR21445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00518">
        <property type="entry name" value="AP2Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00587">
        <property type="entry name" value="nfo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00729">
        <property type="entry name" value="AP_NUCLEASE_F2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00730">
        <property type="entry name" value="AP_NUCLEASE_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00731">
        <property type="entry name" value="AP_NUCLEASE_F2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51432">
        <property type="entry name" value="AP_NUCLEASE_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7 10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="9">
        <location>
            <begin position="38"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AKH81944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="308" mass="32017" checksum="A1E165ACB2F384A9" modified="2015-07-22" version="1">MSSRTPGERRSDGSAARARNPVGSHVRVAGGLAAKGLAHARRIGAEAVQVFVANARGWATPPGDPAQDEEFLRRCAEDGIPVYVHAPYLINLGSHTPATAANSVASLQHSLRRGRAIGARGVVVHTGSATGGRPRETALAQVRELTLPLLDELDDAPDAPALLLEPTAGQGFSLCSRLPELGAYLDLLDRHPRLGVCLDTCHVFAAGHDLAASGGAKQVLDELVEVAGPGRLRLLHANDSKAAVGSRLDRHENIGAGQIGAEAFRELIRHPAMAGVPLIIETPGGGPEGPKAAADIALLKELREPAGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3L2</accession>
    <name>A0A0F7N3L2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cytochrome bc1 complex Rieske iron-sulfur subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Cytochrome bc1 reductase complex subunit QcrA</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Rieske iron-sulfur protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">AA958_06825</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Iron-sulfur subunit of the cytochrome bc1 complex, an essential component of the respiratory electron transport chain required for ATP synthesis. The bc1 complex catalyzes the oxidation of menaquinol and the reduction of cytochrome c in the respiratory chain. The bc1 complex operates through a Q-cycle mechanism that couples electron transfer to generation of the proton gradient that drives ATP synthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the Rieske iron-sulfur protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015326.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_06825"/>
    <dbReference type="EnsemblBacteria" id="AKH81974">
        <property type="protein sequence ID" value="AKH81974"/>
        <property type="gene ID" value="AA958_06825"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_06825"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1427"/>
    <dbReference type="OrthoDB" id="1632945at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045603">
        <property type="entry name" value="QcrA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014349">
        <property type="entry name" value="Rieske_Fe-S_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10134">
        <property type="entry name" value="PTHR10134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19297">
        <property type="entry name" value="QcrA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="96"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Rieske" evidence="16">
        <location>
            <begin position="250"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="14"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AKH81974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="357" mass="39077" checksum="AF06795100B97264" modified="2015-07-22" version="1">MSSQPGSENENNGEHLPTVREGEESGGVAVEERDPFANPGLPPHEPRKQDIDERAAKRSERTVSLLFTVSMLATVGFIVSFVAIDVDKIVYIFPLGHISALNFALGVTLGLALFCIGAGAIHWSRTLMSDVEVIQERHQIESSEETKAITKAQWRQGTEESAIGSRKIIRRTMLGALTLVPLAGVVLLRDLGPLPGTKLRHTLWGKGKLLINMNTDEPLRPEDITVGSLSFAKPEGLKEGDHDFNTEIAKAALMLVRIHPGDIKDKKSADWGHEGILAYSKICTHVGCPVSLYEQQTHHVLCPCHQSTFDLSDGARVLFGPAGHPLPQLRITVNDEGYLYALGDFDEPVGPSFWERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3U2</accession>
    <name>A0A0F7N3U2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HIT family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_07200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015394.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_07200"/>
    <dbReference type="EnsemblBacteria" id="AKH82044">
        <property type="protein sequence ID" value="AKH82044"/>
        <property type="gene ID" value="AA958_07200"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_07200"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1508"/>
    <dbReference type="OrthoDB" id="1934382at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46648">
        <property type="entry name" value="PTHR46648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00332">
        <property type="entry name" value="HISTRIAD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="SSF54197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="2">
        <location>
            <begin position="4"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="1">
        <location>
            <begin position="94"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH82044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="137" mass="15252" checksum="2221F12D86AA439B" modified="2015-07-22" version="1">MNCTFCAIASGELPSHRVFADEVAVGFLDARPLFPGHVLVIPHHHVETLTDLPEPEVGPFFVRVRRLTGAVERGTAAAGSFVAMNNRVSQSVPHLHVHVVPRNRKDGLRGFFWPRTRYRDEEHAVETARLIRAALDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-12-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N409</accession>
    <name>A0A0F7N409_9ACTN</name>
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        <submittedName>
            <fullName evidence="6">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_07510</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="WP_047015454.1">
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH82104">
        <property type="protein sequence ID" value="AKH82104"/>
        <property type="gene ID" value="AA958_07510"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_07510"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1574"/>
    <dbReference type="OrthoDB" id="1927576at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001123">
        <property type="entry name" value="LeuE-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30086">
        <property type="entry name" value="PTHR30086"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01810">
        <property type="entry name" value="LysE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006324">
        <property type="entry name" value="LeuE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH82104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="223" mass="23913" checksum="94B882893E4D7B84" modified="2015-07-22" version="1">MLGVTDLSTYLAGLALIILLPGPNSLYVVSVAARRGARAGYRAAGGVMCGDMVLMVLSAGGVASLLQASPAAFAVVKFAGAGYLTWLAVGMLRGAWRMWREREARAVARAEGEAGRPEPAREEMERPYRRAFVVSLLNPKAILFFVSFFVQFIDPAYAHPELTFVVLAAWAQLFSITYLTALIFSGTHLAALFRRRRRLTAGMSAAAGTAFLGFAAKLSMSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N438</accession>
    <name>A0A0F7N438_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acid phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_07695</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015484.1">
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_07695"/>
    <dbReference type="EnsemblBacteria" id="AKH82134">
        <property type="protein sequence ID" value="AKH82134"/>
        <property type="gene ID" value="AA958_07695"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_07695"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1617"/>
    <dbReference type="OrthoDB" id="1122642at2"/>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
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    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
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        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014636">
        <property type="entry name" value="RNaseH/PGlycerate_mutase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13456">
        <property type="entry name" value="RVT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036922">
        <property type="entry name" value="RNaseH_PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="2">
        <location>
            <begin position="5"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH82134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="407" mass="42730" checksum="7A85EC0E7855AFF3" modified="2015-07-22" version="1">MAGPARRVFTVEADGGSRGNPGPAGYGAVVRDADGGVLAEDAAYVGVASNNVAEYRGLIAGLRAARGLDPDAEVRVRMDSKLVVEQMSGRWKIKHPGMRELAAEAREVFPPGRVSYEWIPREQNKHADRLANEAMDAGRRGERWSAEASRAELGAGTGAAGSREGSEARGEGSGTRAEGGVRAGEAGRTATPAVGWGTDLGAPTTFLLLRHGETALTPQKRFSGTGGGDPALSATGRGQAAAAAGLLAARGTVRAVVSSPLRRCRETAEAAAVRLGLEIRVEDGLREADFGAWEGLTFAEVRERHPDDLAAWLRSTKAAPSGGGESFAEVSRRVAVARDKLLARYAGRTVLLVSHVTPIKTLVRLALGAPPESLYRMELSPAGVSEVAYYADGHASVRLLNDTSHLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N458</accession>
    <name>A0A0F7N458_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_11755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_11755"/>
    <dbReference type="EnsemblBacteria" id="AKH82796">
        <property type="protein sequence ID" value="AKH82796"/>
        <property type="gene ID" value="AA958_11755"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_11755"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2471"/>
    <dbReference type="OrthoDB" id="1693549at2"/>
    <dbReference type="Proteomes" id="UP000034283">
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    </dbReference>
    <dbReference type="InterPro" id="IPR027304">
        <property type="entry name" value="Trigger_fact/SurA_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109998">
        <property type="entry name" value="SSF109998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519221" evidence="1">
        <location>
            <begin position="32"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="217" mass="23285" checksum="C09E463B7FE4D259" modified="2015-07-22" version="1">MRRTALAVTAAAFIAAVPLLSSCSGEPRAGAAAVLGDDERITVSQLQNRVADVRAAQNASPQADEMIDQSGDLSVDTLNTMLQGRVIEQAAESHGVTVPRGEVQRTRRAEADSVGGEKQLEAMYLQQYSIPPEGLDTHYKQQLMVQGLVEKLGINPQTQEGQARLGGVLVEASKDLGIDVSPRFGKWDNEQVRLGQADTPWIKQVNATAEDGALPQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N482</accession>
    <name>A0A0F7N482_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FAD_binding_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_08060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015543.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH82193">
        <property type="protein sequence ID" value="AKH82193"/>
        <property type="gene ID" value="AA958_08060"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_08060"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1700"/>
    <dbReference type="OrthoDB" id="1770293at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="2">
        <location>
            <begin position="14"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="458"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH82193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="477" mass="52209" checksum="141AD55AB8BFFFD8" modified="2015-07-22" version="1">MTDISTGARGGRAIVIGGGLTGMLAAWALAEVMDEVTVLERDREPTGPDFRPGVPQGRHAHAFMEGGQRALEELLPGIIDELVEAGATRTKLPAELLWLDYAGWNDRGTAIRGGAGSFLTCTRPMLDWIVRSRVLKSPRITVRHGVTVSALLCSEDAVRGVVAQEKGGEPEELKAPLVVDASGRGSNAPRWLRELGYPEPKEELIDSGMAYASRLLHRTPESEKESFNVVMIQPVLSTPRFGLLIPVEDNRWLVALGGLRGYEPPTESDDWTQFAKELRSPMIYKMIENAEPATNVFGFRNTQNRRRYYEKLSRRPDGFLVLGDAACTFNPVYGQGMSVACFEGLALRKLLAKHGAGKGMTRKAQKMVARTIRNPWTMATSEDRRYPTTVGGGRPNALERMLDWYVKRVSAEALVNPVAGKAFFSVVMLLEPPTHLFRPGVVLAALRRRGASITVPEPVLAGAQTDDEGPGVPSGNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-08-12" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4P9</accession>
    <name>A0A0F7N4P9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DeoR faimly transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_12880</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016305.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH82971">
        <property type="protein sequence ID" value="AKH82971"/>
        <property type="gene ID" value="AA958_12880"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_12880"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2710"/>
    <dbReference type="OrthoDB" id="1654295at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013196">
        <property type="entry name" value="HTH_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028349">
        <property type="entry name" value="PafC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026881">
        <property type="entry name" value="WYL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08279">
        <property type="entry name" value="HTH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13280">
        <property type="entry name" value="WYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016838">
        <property type="entry name" value="PafC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="3">
        <location>
            <begin position="2"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH82971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="324" mass="35256" checksum="6B4F54BE93FE023C" modified="2015-07-22" version="1">MRADRLVSLVLLLRQRGRLSAATLARELEVSTRTVLRDIEALSAAGVPVHSERGRHGGFALLPGFRTELTGLNHDEALALLIAGSRRGAQAFGLGSALASAMLKVVDALPPGYRDTAAGVAERLLVDPETDLLARPLTADEVPDEVMAALRGAVFAGRKLRIRYAPEGRAAAWRTVDPIGLVTVRDKGYLLAARDGADRTYRLSRVRAAEELPEPAQRPERVDLDRAWQERSARFRSGGDRVAVAVRITPRRREELVGTALAVLAEDVEPDGRLRLEVAFQDARHAEWAVWQLATDAEALTPGWLRTALRDRAAALAAHYASPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4R5</accession>
    <name>A0A0F7N4R5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_09275</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015734.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH82388">
        <property type="protein sequence ID" value="AKH82388"/>
        <property type="gene ID" value="AA958_09275"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_09275"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1957"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519046" evidence="2">
        <location>
            <begin position="37"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH82388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="130" mass="12775" checksum="FF318BA29C3FC15C" modified="2015-07-22" version="1">MIVRAALVRGLALRAVLVLLLGVLLVPGGAAERASAADGYSTSSAAPGAAGAAGEAAPGEDTGPAPALARRGPRSAKAGQIDQAGHVAAAGRPVPRTARGAEKTGSPWCPYAPEAAVLAAARTRYAVLRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4X6</accession>
    <name>A0A0F7N4X6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_13405</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH83061">
        <property type="protein sequence ID" value="AKH83061"/>
        <property type="gene ID" value="AA958_13405"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_13405"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2819"/>
    <dbReference type="OrthoDB" id="2047616at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH83061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="135" mass="14041" checksum="462820BBD969D485" modified="2015-07-22" version="1">MALAGGAGGEMGRDAWAGLVRLVRMPFRRDGGDDAGGSSAEAELTRLAEEPADEARAQALSTALAVRAALDGEFRAALRTWHEELPPLPGDGADSVSNSVSGQVWYGPVVQGRDFHAADGIHIQSGTPPPDAPQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N560</accession>
    <name>A0A0F7N560_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Streptogrisin B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_10100</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015861.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_10100"/>
    <dbReference type="EnsemblBacteria" id="AKH82519">
        <property type="protein sequence ID" value="AKH82519"/>
        <property type="gene ID" value="AA958_10100"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_10100"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2127"/>
    <dbReference type="OrthoDB" id="1110723at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001316">
        <property type="entry name" value="Pept_S1A_streptogrisin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001134">
        <property type="entry name" value="Streptogrisin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00861">
        <property type="entry name" value="ALYTICPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519205" evidence="3">
        <location>
            <begin position="36"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="150"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="186"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001134-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH82519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="236" mass="23178" checksum="AA2D57F7448EA066" modified="2015-07-22" version="1">MSRRRTAPPLRTTATAAVLAVLGALLTVLAPPASASDAGRPAAATAVRGGEALYGPSYACTLGFNAVSGGTSYGIIAGHCADVGSTWAVEAEGGRVSVGVTSGSVFPGSDYGVVRYTNTSVSYPGEVKGSGGAPVDITGAADPAPGMSLCHYGRVGGYRCGTVQAVNLTVNFPGGTVSGLFRSSICSEPGDTGGPAFSGGRAVGIIVGGSGNCTSGGVTYYQPVKEILAAYGLTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5B5</accession>
    <name>A0A0F7N5B5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PfkB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_14255</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the carbohydrate kinase PfkB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016521.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_14255"/>
    <dbReference type="EnsemblBacteria" id="AKH83201">
        <property type="protein sequence ID" value="AKH83201"/>
        <property type="gene ID" value="AA958_14255"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_14255"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3000"/>
    <dbReference type="OrthoDB" id="1604782at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002139">
        <property type="entry name" value="Ribo/fructo_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00990">
        <property type="entry name" value="RIBOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="5">
        <location>
            <begin position="3"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH83201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="317" mass="33246" checksum="6B29A86A1326EF52" modified="2015-07-22" version="1">MDNDILAIGEPLLEFNARAEGREPVGPGDDFAVGYGGDSSNFAVAAQRSGARTGYVTRIGDDDFGGALLRLWEWEGVGTEHVIREAGGRTGIYFISRTPAASRFTYYRADSPASRLTPADVPAAAIERARMLHVTGITQAISPSACDAAFHAMELARGSGTLVGYDPNYRPALWPVERARAVVMRSVELCDVALPNLEEGRLLTGLHEPEEVLDAFVRRGPGIVVLKMGDQGALLAHEGTVTRIPPHPVRAVDPSGAGDTFDGAFAARLLEGAVPPEAARYAAVAAALTTTGPGAVLPIPHRAAVDALLPGAPTPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5G8</accession>
    <name>A0A0F7N5G8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_15040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016631.1">
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_15040"/>
    <dbReference type="EnsemblBacteria" id="AKH83316">
        <property type="protein sequence ID" value="AKH83316"/>
        <property type="gene ID" value="AA958_15040"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_15040"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3169"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="94" mass="10460" checksum="2363C263631F978B" modified="2015-07-22" version="1">MPNRSRPSAAAVIAGIADLAAIVIGLWILLYVLDANRSNDFVAFVHDIASWLAGWSRDMFTVDPDWWQVLLNYGIAACVYLAVGHTVSRTVKRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5J0</accession>
    <name>A0A0F7N5J0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CDP-alcohol phosphatidyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_07395</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_07395"/>
    <dbReference type="EnsemblBacteria" id="AKH82082">
        <property type="protein sequence ID" value="AKH82082"/>
        <property type="gene ID" value="AA958_07395"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_07395"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1550"/>
    <dbReference type="OrthoDB" id="1232102at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016780">
        <property type="term" value="F:phosphotransferase activity, for other substituted phosphate groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="64"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH82082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="229" mass="24082" checksum="4EEDC25705149EF0" modified="2015-07-22" version="1">MRNAQKTAKGVSLYSRRVNRPLGRVFAAGAYVLGLRPNHVTLLSAAFTGGGIAAVALVRPGWGLALAVYALLVVGFALDSADGQLARLRRESSAAGEWLDHVVDCAKVTAVHAAVLVSFYRFFDLSSDAWLLLPLGFQLAAVLIFCGGLLADKLKPKPAPGAAPAPAPPPSRLRAVALLPVDYGVFCVVFLLLGSESAFLAGYTALALAAALFLIAFMAKWFRELSATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5J6</accession>
    <name>A0A0F7N5J6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ArsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_11000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016006.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_11000"/>
    <dbReference type="EnsemblBacteria" id="AKH82668">
        <property type="protein sequence ID" value="AKH82668"/>
        <property type="gene ID" value="AA958_11000"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_11000"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2316"/>
    <dbReference type="OrthoDB" id="1617768at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="111" mass="12517" checksum="29696C5C16352F2B" modified="2015-07-22" version="1">MLKYEAEAADRVFHALADANRRAVIERLTHGPATVSELAAHLRVTVAATVQHLRVLQDSELVRSEKAGRVRTCQLDPAGLRSAEAWLQRRRTAWEHRLDRLGAVLDDQTKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5R1</accession>
    <name>A0A0F7N5R1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Anti-sigma factor antagonist</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_11520</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the anti-sigma-factor antagonist family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016094.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_11520"/>
    <dbReference type="EnsemblBacteria" id="AKH82758">
        <property type="protein sequence ID" value="AKH82758"/>
        <property type="gene ID" value="AA958_11520"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_11520"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2424"/>
    <dbReference type="OrthoDB" id="1864829at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043856">
        <property type="term" value="F:anti-sigma factor antagonist activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003658">
        <property type="entry name" value="Anti-sigma_ant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00377">
        <property type="entry name" value="ant_ant_sig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="3">
        <location>
            <begin position="14"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH82758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="122" mass="12871" checksum="FE0CABF7F2D2F614" modified="2015-07-22" version="1">MDAGTAGSPSRGRLHVDVRVHGGSAVLTPAGELDYHTAEVLREPLERCIAGGRSRLVLDCSRLEFCDSTGLNVLLGARLKAEADGGAVHLAGLRPVVARVFEITGAEAVFRLHDTLESALVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5R2</accession>
    <name>A0A0F7N5R2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Diaminopimelate decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_11555</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Orn/Lys/Arg decarboxylase class-II family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_11555"/>
    <dbReference type="EnsemblBacteria" id="AKH82763">
        <property type="protein sequence ID" value="AKH82763"/>
        <property type="gene ID" value="AA958_11555"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_11555"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2431"/>
    <dbReference type="OrthoDB" id="861683at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022643">
        <property type="entry name" value="De-COase2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022657">
        <property type="entry name" value="De-COase2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022644">
        <property type="entry name" value="De-COase2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000183">
        <property type="entry name" value="Orn/DAP/Arg_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02784">
        <property type="entry name" value="Orn_Arg_deC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00278">
        <property type="entry name" value="Orn_DAP_Arg_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01179">
        <property type="entry name" value="ODADCRBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="SSF50621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00879">
        <property type="entry name" value="ODR_DC_2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orn_Arg_deC_N" evidence="3">
        <location>
            <begin position="57"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="Orn_DAP_Arg_deC" evidence="2">
        <location>
            <begin position="302"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH82763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="454" mass="47239" checksum="284E0911346584A8" modified="2015-07-22" version="1">MPDDEPVPVPQNLPLAARRDLAVHAALAQGLVSGAEPVAGLLDVAGIRESAAALRAAFDEVIAPGTPVLHSFAVKAASLVPVLRLLADEGLGAEVASPGELELARAADVPPDRTVLDSPAKTPAELRGALALGIAVNADNPEELARIDALVRSAPTRSTIGVRINPQVGGGSIGAMSTATATSKFGVTLQDEGARDWLVRAYVDRPWLTALHTHTGSQGVPLPLMAAGVRAAYELAEEINAAAGRRQVTTLDIGGGLPVNFGSDEVTPSFADYARLLRAEIPGLFDGRYALITEFGRSLLAKNGLVLARVEYAKSAGGRPIAVTHAGVQVAVRTVFAPDSWPLRVTAYDAEGRPKTGTPVAQDVAGPCCFAGDLVARARELPPLAAGDHVALLDTGAYYYSNPFSYNSLPRPAIHGFTTAGTEVRFATVRTAQTLQEIVKESGGPHCTSLTTLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N611</accession>
    <name>A0A0F7N611_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glycerophosphodiester phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_12095</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016188.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_12095"/>
    <dbReference type="EnsemblBacteria" id="AKH82853">
        <property type="protein sequence ID" value="AKH82853"/>
        <property type="gene ID" value="AA958_12095"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_12095"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2545"/>
    <dbReference type="OrthoDB" id="1112046at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032524">
        <property type="entry name" value="ABC_tran_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16326">
        <property type="entry name" value="ABC_tran_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="7"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="292"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="518"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="550"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="39"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="328"/>
            <end position="335"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH82853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="619" mass="67789" checksum="62CF48897A99AAF6" modified="2015-07-22" version="1">MAAANLVNLEAVDKVYGTRTLLDGISLGVAEGDRIGVVGRNGDGKTTLVRLLAKLEEPDAGRVTHTGGLSLGVLTQGDTLDPAATVRHEVVGDMADHEWAGDARVRDVLTGLFGGLDLPGFEQGLDTVIGPLSGGERRRIALAKLLIGTPGLIVLDEPTNHLDVEGIAWLAEHLRTRRAALVVVTHDRWFLDQVCTRMWDVQRGAVHEYDGGYSDYVFARAERERIAATEEAKRQNLVRKELAWLRRGAPARTSKPRFRIEAANALIADVPPPRDSAELMKFANSRLGKTVFDLEDVTVRAGGGPEGRVLLTGLTWQLGPGDRVGLLGVNGAGKTSLLRTLADAARSGGETQPAAGRIVAGRTVRLAYLSQEVTELDPDWRLLESVERVRQRVDLGRGREMTASQLCEQFGFGREKQWTPVGDLSGGERRRLQLLRLLMDEPNVLFLDEPTNDLDIETLTQLEDLLDGWPGTLVVISHDRYFIERTTDTVHALLGDGTLRMLPGGIEEYLRRRARIRETQQDRQPQAQAAAGAQPQPQARPAAGLSAADARAAKKELQRIERQLDRIGGKEGDLHAAIAEHATDFARVAELDAQLRELTAEREELELRWLELAEAAEAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N635</accession>
    <name>A0A0F7N635_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_16305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_16305"/>
    <dbReference type="EnsemblBacteria" id="AKH83511">
        <property type="protein sequence ID" value="AKH83511"/>
        <property type="gene ID" value="AA958_16305"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_16305"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3435"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="57" mass="6569" checksum="31A3433CC2FF3513" modified="2015-07-22" version="1">MYGWIWRHLPGNALVRALISLILVLGIVFLLFQYVFPWAEPLLPFNDVTVDEGAARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6K7</accession>
    <name>A0A0F7N6K7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_09555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015776.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_09555"/>
    <dbReference type="EnsemblBacteria" id="AKH82432">
        <property type="protein sequence ID" value="AKH82432"/>
        <property type="gene ID" value="AA958_09555"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_09555"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2014"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF13302">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="24"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="184" mass="20647" checksum="5AA0CF206CC683F0" modified="2015-07-22" version="1">MPQLTTPHIRFRASFAGAMKEFEAEGRGAVGDDTSIGQDLRRWRRRWHDPAVFASYVAGLRAEADETIPMIRPGWVHCTTLWYVDGDAYLGRIAIRHSLTGWLREQGGHIGYDVRPTARRRGHATAMLREALPVARGLGLAEVLVTCDHDNVASRKVIEANGGVFEDRRGLKLRYWVATGEPKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6P7</accession>
    <name>A0A0F7N6P7_9ACTN</name>
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        <submittedName>
            <fullName evidence="1">2-hydroxycyclohexanecarboxyl-CoA dehydrogenase</fullName>
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    <gene>
        <name evidence="1" type="ORF">AA958_09780</name>
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    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_09780"/>
    <dbReference type="EnsemblBacteria" id="AKH82472">
        <property type="protein sequence ID" value="AKH82472"/>
        <property type="gene ID" value="AA958_09780"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_09780"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2061"/>
    <dbReference type="OrthoDB" id="1209997at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH82472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="260" mass="26535" checksum="33F2BF316E89AC7E" modified="2015-07-22" version="1">MLLQEKNAIVYGAGGAIGAAVARTFAREGARVHLTGRHAANVELVARDINESGGTAHAAVVDALDEHAVEEHAARVAEEAGSLDVSINLITRNDVQGTPLVDLSVSDYVSCVTRGLTTNFVTARAAGKRMAAQGSGVILALNSGSSHTSPMMGGTCPADAAIDTLIRSLAQELGPSGVRAAGLWAAGVPETLTPQKLGAVNPAMATPEALRGVLDTLDGLRMLPASPRLKEIADLAAFLASDHAGAVTGTWVNATAMFPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7D5</accession>
    <name>A0A0F7N7D5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_14985</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
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            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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    <dbReference type="STRING" id="444103.AA958_14985"/>
    <dbReference type="EnsemblBacteria" id="AKH83308">
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        <property type="gene ID" value="AA958_14985"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_14985"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3158"/>
    <dbReference type="OrthoDB" id="1942521at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
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        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519277" evidence="2">
        <location>
            <begin position="28"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="3">
        <location>
            <begin position="63"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH83308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="333" mass="34968" checksum="EC0A535E791D00F8" modified="2015-07-22" version="1">MTRLLLTAAVATAATLTLAACGTTEDAADDDDKGGAGKGAAQPITLTDSTGKKVTLEDGPATKVVGTEWNVVENLVSLGVDPVGVADVKGYNTWDSAVPLTNEPEDIGTRGEPSIDTIASLNPDLIIATSDLPESAVKQLSERTPVLTLRSADASDPVGQMTENLDLIAKATGTTDRAEKLKKDFDAKLDEGRKALDDAGLGGAKVAFADGYVVSNQVSIRPFTSGSLLGGVNERLGLENAWDVKGDKDYGLGSTDVEGLTKLPEDTQFVYIGNDEDEASTPFTGELKDDSVWKSLPFVKAGDVHRLDDGIWMFGSVESMNQYVDALVGALTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7H7</accession>
    <name>A0A0F7N7H7_9ACTN</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_19375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH83986">
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        <property type="gene ID" value="AA958_19375"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_19375"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4073"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
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    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="389" mass="41548" checksum="4CDE12BFF1E329B5" modified="2015-07-22" version="1">MTSVTDRYDPLDAEILRDPYPVLAELRVRAPVFWHAGMDSWALTQYADCVRVLRDHERFARDPRRTGGTAPEPSLSVQTLDPPQQNAVRSLFMTALRAQDLTGIEDRARLLVGERLDQLAGGGPFDVVAEIAVPLSVAVVADLLGVEPPPYGEFAAVSDAIMRSMDGGLDPALVEPGRVARQQLSDLVDSWFTASARPGLLARVRQATAPGSDPLTRLYVKNTARVMFQGGYSTMAAAIGNAVHTLLAHPGALGQMRDGELLAAGVDELVRFDGPVQGTTRTAVRSCRIGGVDIAPGQKVVPLFAAANRDPAAFVQADDLVLDRTPNRHLGYGWGPHACIGTTVAQAGLRALVTALNDHPARLAAAGVGVRRRTATMRAFHTLPAALIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7P2</accession>
    <name>A0A0F7N7P2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Repetin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_15855</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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        </lineage>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016750.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH83438">
        <property type="protein sequence ID" value="AKH83438"/>
        <property type="gene ID" value="AA958_15855"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_15855"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3340"/>
    <dbReference type="OrthoDB" id="2027902at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519286" evidence="2">
        <location>
            <begin position="30"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH83438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="205" mass="21316" checksum="89E13778D1EE8B61" modified="2015-07-22" version="1">MRYVRSNRLRAVALAAALLATATAGTAAAAGDARTDDRGARNVHDAGGTDSAPGADRGQRPAASLTGTAKLTRSLGDDITFSFDARLAAKHNDNPRQATGTFRFSHYLGGEGAWAEADVDCLVTGGKVAVVSGVITDTDLPGAKGLRVGVTVHDQGRHDRLGYSWAATGSPVEDEDLVPCVSSAPFEKVKGGTGDFRVQPWQPEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N816</accession>
    <name>A0A0F7N816_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alkyl hydroperoxide reductase / thiol specific antioxidant / Mal allergen</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_16560</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016859.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_16560"/>
    <dbReference type="EnsemblBacteria" id="AKH83554">
        <property type="protein sequence ID" value="AKH83554"/>
        <property type="gene ID" value="AA958_16560"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_16560"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3485"/>
    <dbReference type="OrthoDB" id="966287at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="NHL2_NHL_rpt_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001258">
        <property type="entry name" value="NHL_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
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        <property type="entry name" value="NHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13905">
        <property type="entry name" value="Thioredoxin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="3"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH83554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="615" mass="65668" checksum="C36E6C8B78E819A9" modified="2015-07-22" version="1">MAKRARVRAPELAGSGGWLNTGGVELSLAALRGRVVILDFWTFCCINCLHVLDELRELEEKHRDTVVVVGVHSPKFVHEAEHAAVVDAVERYGVHHPVLDDPELATWKQYAVRAWPTLVVIDPEGYVVAQHAGEGHVHAIERMVAELEAEHAAKGTLRRGDGPYRAPEPVATHLRFPGKVLRLPSGNLLVSDTTRHRLVELEPDGETVVRSIGSGERGYADGAAPRFNEPQGLALLPSGAVAVADAVNHAIRAVDLGTGSVTTLAGTGRQWWQGSPAAGPGREVDLSSPWDVAWFDGRLWIAMAGVHQLWTYDPETDTVRAAAGTTNEGLLDGPAEEAWFAQPSGLAATAGRLWIADSETSALRWLEPGGGPGRRARVHTAVGTGLFDFGHRDGPAGEALLQHPLGVTALPDGSVAVSDTYNHALRRYDPATGTVTTLATDLREPSDAVVDGDEIVVVESARHRLTRLRLPDEAVRVTPVAHRTRRAATDVAPGALSLDVVFRPPPGQKLDTRYGPATRLLVSATPPSLLAAGEGAGTDLTREVTLSADGPGEGVLHVSAMAASCDDDPSVEYPACHVHQQDWGVPIRLTESGARRLPLILAGLDEGEEKEEEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8C2</accession>
    <name>A0A0F7N8C2_9ACTN</name>
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        <submittedName>
            <fullName evidence="7">Peptide ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_17330</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
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        <property type="protein sequence ID" value="AKH83679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016983.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_17330"/>
    <dbReference type="EnsemblBacteria" id="AKH83679">
        <property type="protein sequence ID" value="AKH83679"/>
        <property type="gene ID" value="AA958_17330"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_17330"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3644"/>
    <dbReference type="OrthoDB" id="1734230at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="101"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="220"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="265"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="99"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH83679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="301" mass="31094" checksum="EF7B17D8E6A528D2" modified="2015-07-22" version="1">MSGTTTAAPAQAVDSPRTDKSRGDAARRVPVRVWTGAGVLALFVLAALVGPLLHPYDPVATDLPNRLLSPGERTDGGDIAWLGTDQMGRDLLANLLAGARISLLVAAATILVGGAVGLVVGLVSGYFGGWPDTIASRIGDIQLAFPSILLAILLAGVLGPSVTNIVITLAITRWVIFARVARASAMATRKLGFVDSARVLGAGHVRIMVRHVLPSLWQPLLVAATVQVGLVMVAEASLSFLGLGVPVDTSSWGATVSVGRDYLGSAWWISTMPAAALALVVTAVGVIGDGFRDVSDPRSQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8F4</accession>
    <name>A0A0F7N8F4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AA958_17910</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017075.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH83773">
        <property type="protein sequence ID" value="AKH83773"/>
        <property type="gene ID" value="AA958_17910"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_17910"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3772"/>
    <dbReference type="OrthoDB" id="149255at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004869">
        <property type="entry name" value="MMPL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03176">
        <property type="entry name" value="MMPL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="203"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="238"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="281"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="314"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="372"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="515"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="541"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="573"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="615"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="643"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="8">
        <location>
            <begin position="203"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="691"/>
            <end position="710"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH83773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="710" mass="74515" checksum="0D71198CF7F1B27E" modified="2015-07-22" version="1">MSARIKQLVAAPGGQRTKWLVLAAWILLLVALGPLAGKLGDVEDTGPNAFLPRSAESAELNTELEKFRGDPEDEVMPAVAVYSVPEGAMTDAGRLKAEADVRAFAPYVAAGERVTPPMPSDDGGALMTIVPITDEDDLTDTVEDVREVAADGAPPGVDVEVGGPAASLADSVAVFDSLDATLMLATLAVVTVLLLITYRSPVLWLFPVLAVGFAAVLTQAATYLLAKHASLPVDPQAAGILMVLVFGVGTDYALLLIARYREELHRHENRHEAMQLALRRCFPAILASAATIAVGLSCLYFADISSSRSLGLVGAVGAVCAFLALVTVLPTLLVIVGRWVFWPFVPRHGTPVHGHRTVWSRIGAAVARRPRWSWLMSLGVTALLVFGVVGMDFGLKQSELFQDKPESVVAQERISAHYPSGASDPADIVTNADAKDAVRAAAGKVDGVAGVADGGTTGDLAALRVTLDDEPDSDAAKDTIDDLRAAVGAVDGADALVGGTTAEALDTQRAADRDLRVVVPIVLLVVFLVLIGLLRALVAPLVLLATAVLSNVAALGASYLLFDHVFDFAAVDWSIPLMGFVFLTALGIDYNIFLMTRVREEVALHGHAKGVLTGLTSTGGVITSAGIVLAATFSVFAGLPLVTMAQLGVLVGVGVLLDTFLIRTVMVPALALDLGKWTWWPGALFRQETRRPPAAADTAAGLPEADRVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8X7</accession>
    <name>A0A0F7N8X7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_14230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_027773296.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH83197">
        <property type="protein sequence ID" value="AKH83197"/>
        <property type="gene ID" value="AA958_14230"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_14230"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2995"/>
    <dbReference type="OrthoDB" id="1918406at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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            <begin position="21"/>
            <end position="37"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="122" mass="13751" checksum="6448F18FF2F4EB83" modified="2015-07-22" version="1">MPRERQSLAFRALRSPTIRRLLILVLLIVAYQVWLTVQASGKVDPAVGDERDMRGRFSADVELGFPPERYHILRMQKHGRIAGTDGNVVHLRGVAPAGVDALAREYWIERIVPPEDETPAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
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        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">CNQ-509</strain>
        </source>
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    </dbReference>
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        <location>
            <begin position="10"/>
            <end position="76"/>
        </location>
    </feature>
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        <location>
            <begin position="79"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH83978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="115" mass="12640" checksum="85464678FCD5829E" modified="2015-07-22" version="1">MTAKLDYQWHLRKVMADRGMFSTTDLIAPLEERGISLSSSQVYRLVVERPERLSLKVLMALLDILDCRMNDLIEPVRAAGTAARPRKKAAAGGAAPEPGLGALRPKRARITGVDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N949</accession>
    <name>A0A0F7N949_9ACTN</name>
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        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">AA958_19760</name>
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    <organism evidence="2 3">
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">CNQ-509</strain>
        </source>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <begin position="26"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="286" mass="31917" checksum="DE948B6A699F8C79" modified="2015-07-22" version="1">MTVRHRTARIDGLDVFYREAGDPGAPTLVLLHGFPTSSVGFAPLMAELAGEFRLIAPDYPGFGLSSAPPAGEWAYTFDHLADVVDKLLDQLGVRRYAIYVHDYGAPVGFRLALRHPERITGIVSQNGNAYDEGFTPFWTPLRAYWAEPTPANREALRSLLTPDATHWQYSHGVPDTSLVDPALEVHDQALLDRPGNQEIQLDLFLDYGTNPGRYADWQEYLRVHQPPVLAAWGRHDEIFGPDGARAFARDVKDAQVQLLDAGHFPLTTRFAQSAGLIRDFLRRLSD</sequence>
</entry>
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    <accession>A0A0F7N9A5</accession>
    <name>A0A0F7N9A5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Beta-lactamase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_26080</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
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        <property type="gene ID" value="AA958_26080"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_26080"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5491"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="1"/>
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        </location>
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            <end position="395"/>
        </location>
    </feature>
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            <begin position="72"/>
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        </location>
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        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH85115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="395" mass="42288" checksum="8E80E722385393DF" modified="2015-07-22" version="1">MTTYGDIRARRLLAALLVLLVLPAAAACGADRDRDRDVRDDGAAGIRTQARAGDPATRAVEKYLDEVWPEDAPGTVVAARGGAAVTCSGRGPADPGTGARAGCGTVYDIASMTKQFTAAAIVKLQTEGKLRVTDPLSRHLDGVPADKRGITLHHLLTHTAGLPESLGDDYDPLSRAGLVSGALATPLHSPPGERYAYSNTGYSLLAAVVEEASGTGYEPYLAGHLFRPAGMTDTGYVLPDWDRDRIAVEYDRRGRPQGRPMDHPWAGDGPYWNLRGNGGMLSTARDMLRWHRALLGDRVLPAKARKLLFTRYVPEGGGAGSFYGYGWSLLDLGGAPVATHDGGNEWSSGRVARFLDDGTLVFWISNAATRAGAWDLPDLDRELTTGIAERVRERA</sequence>
</entry>
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    <accession>A0A0F7N9B6</accession>
    <name>A0A0F7N9B6_9ACTN</name>
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        </submittedName>
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    <organism evidence="3 4">
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AKH84621">
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    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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            <begin position="382"/>
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        </location>
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        <location>
            <begin position="1"/>
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        </location>
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            <begin position="116"/>
            <end position="130"/>
        </location>
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    <feature type="compositionally biased region" description="Pro residues" evidence="1">
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            <begin position="152"/>
            <end position="166"/>
        </location>
    </feature>
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        <location>
            <begin position="265"/>
            <end position="279"/>
        </location>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="690" mass="68029" checksum="1858152F70C0AFAE" modified="2015-07-22" version="1">MGEPTAPAPGTGAGGDGGAGVPATETTLTTRIRINIPGSRPIPPVVVRQPLEAGAEEPDTSGAGVPAPAPGPAEAAAAAANGQNGGSAKPRTSDWFAPRKAPKDPAAAQGAPEAAPTPLPAQPPMTPPSGPTGTTDGAGMQFPAFAPPGDAGAPLDTPPAGVPQPHPAPGDTGAVDVPVSESGHGFAGDDPANALPVRPAPAGGTPRRGPGAPGGVPSGPTSGPATGSMPLKPAGPAAGRTLRGSAAPQAPTGGMGDTAVGGIPVVPPGPDPAPAHGVPQGPGHTPAHGVPQAGPQGPGPGHTPAHGLPQAGPDGARYPQEAASVPGFSPAGQPPPGAAPPPGPVPAPGGDGPPVPPPAPASAARSRSGSPSGRARGDRKKLAVMAGAGVFGVLCIAYGAGLVLNNDDVPKGTTVLGVDIGGSSRDQAVAKLDAAVEKRTQAPIVLRVGDQEQKLTPQSAGLGIDTAESVRSAMGSDYNPVSVIGSLFGGSREVDPAMVDDTDKLRAQLQEIADEAGGGRDGMIRFVDGKAVPVKGEPHEAVDVEKSMDAVRKAFDERAAGGANKPVTLPVSQQEPAVSQAEFDTAMNGFAKTAMSGYVAVQAGGAYIEFSPERSISEFLTMQATPDGKLAPKFDLEKLEELYGSTFDGLMVQRGDGSTTEITPNDVASAMMGPLRETDPAKRVGVIDIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9C4</accession>
    <name>A0A0F7N9C4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_26185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH85135">
        <property type="protein sequence ID" value="AKH85135"/>
        <property type="gene ID" value="AA958_26185"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_26185"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5512"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="86" mass="8552" checksum="293C81A97DCA3F07" modified="2015-07-22" version="1">MSASTGPGGPVIRAITSSAGRPSSPGRISTSHSRPAGSRATPSGLRSHSHLQISGSDAAETSHSTADSAPAPVITPVSRLPSHRSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9G1</accession>
    <name>A0A0F7N9G1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AA958_19950</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017369.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_19950"/>
    <dbReference type="EnsemblBacteria" id="AKH84079">
        <property type="protein sequence ID" value="AKH84079"/>
        <property type="gene ID" value="AA958_19950"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_19950"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4203"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018391">
        <property type="entry name" value="PQQ_beta_propeller_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002372">
        <property type="entry name" value="PQQ_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01011">
        <property type="entry name" value="PQQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13360">
        <property type="entry name" value="PQQ_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00564">
        <property type="entry name" value="PQQ"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="353"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="8"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="271"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="379"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="685"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="293"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="688"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AKH84079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="740" mass="76653" checksum="77AD3BEE68F4B495" modified="2015-07-22" version="1">MRVIADRYELVAFVGRGGMGEVWEGRDRVIGRRVAVKLLPDHQHGPAADLFFREARTAGGLNHRGVVTVHDLGRDPGDGTLYLVMEYVAGRNVAVVLREDGPPSPAVGVEWAAQTTAALAAAHDAGVVHRDLKPANLMLTTGGEVKILDFGIARFMAATDKSSQVMGTLAYMPPERFAQHSGDARSDLYAIGCILHELLTGQVPFDADDPVSLMTAHLTRAPEAPSVRRSGIPVALDDLVLRLLAKEPADRPQSAASVHDELRALDLASVRPQEPGPADADGSRAVTPTPTATPTAPGTPPAPAPADPPPYAPPAPGQPPAAHRLPTRTAAPAAPGNAPGAGGGPAAPGRRRALLYGLGGAVVLVAGGGLALALATDDGAKRADGGGSGATGPEADAAPKRKVRPWRYDITSEPPTACAVADGVLYVSADFRITALDARTGKKLWAGPRFSFLPDQPTAADGTVYVGGGEELWALDADGKKKWTFPTGDRIRSRPTVSGGIAGIVYCTSLDTNVYAVHADGGRKAWSFPCGDELYSSPTVADGTVYVGCAGKDNTLYALDAASGDLKWTFPADKGFPQAPLVSGGLVYAGAGDGRLYAIHADEGTKKWSIEGTAATKQTLYLADDTVYAAGDDGRVHAFDASSGDKKWTNEGMSTVNPTQLAVAGGLVYFGETLSDVGSVRALDTGDGSERWTTSTLSSLSPGNRENGPVTAYDFVYVTNENGVVALDAATGAAPDLGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9H5</accession>
    <name>A0A0F7N9H5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_15300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016665.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH83352">
        <property type="protein sequence ID" value="AKH83352"/>
        <property type="gene ID" value="AA958_15300"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_15300"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3221"/>
    <dbReference type="OrthoDB" id="2068706at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519392" evidence="1">
        <location>
            <begin position="27"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="59" mass="6336" checksum="D0176920D64BDD2D" modified="2015-07-22" version="1">MDYKKIALGLLGLFAIYSIISSPSQAADLVQVVFEWISELAKAIGDVMSDLLDDASSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9K0</accession>
    <name>A0A0F7N9K0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GCN5 family acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_15485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016689.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_15485"/>
    <dbReference type="EnsemblBacteria" id="AKH83377">
        <property type="protein sequence ID" value="AKH83377"/>
        <property type="gene ID" value="AA958_15485"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_15485"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3258"/>
    <dbReference type="OrthoDB" id="1826274at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017255">
        <property type="entry name" value="AcTrfase_GNAT_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037663">
        <property type="entry name" value="Acetyltransf_GNAT_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="151" mass="16241" checksum="3A56B8114830A26A" modified="2015-07-22" version="1">MTAEATHIGPAGVADFHRVLADHPRYWGERNLRALHLLAMVQEFGDTCLVARAGDGIRGYVFGFVTPSRTGYVHLIATRDDARGTGLGRRLYGAFAAAAARQGAERLKAITSVANTGSQAFHRGLGFAARVEEDYDGAGRPMVVFGRDLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9K3</accession>
    <name>A0A0F7N9K3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DeoR faimly transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_23715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017970.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_23715"/>
    <dbReference type="EnsemblBacteria" id="AKH84716">
        <property type="protein sequence ID" value="AKH84716"/>
        <property type="gene ID" value="AA958_23715"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_23715"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4998"/>
    <dbReference type="OrthoDB" id="869726at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00046">
        <property type="entry name" value="DAGKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="SSF111331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAGKc" evidence="1">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="322" mass="34270" checksum="BC9A372AAC97A401" modified="2015-07-22" version="1">MRALLVVNPAATDTSARTRDVLIHALASDLKLETVTTEYRGHARDVARHAAESGEVDIVVALGGDGTVNEVVNGLLHRGPAPGDLPRLAVVPGGSTNVFARALGLPNDAVEATGALLDAMHSGSERTVGLGLASGTPDTDDEGAPARWFTFCAGMGFDAGVVGRVEQKRERGKKSTHPLYVRQLLRQWLGEGDRRHGTITLRRPDGDPVEGLVLSLVCNTSPWSYLGNRPLYATPGASFDTALDVLGLARLSTPSLLRYGTQLLTSSPERGPHGKHAASLHDLTDFTLESQAPLPFQMDGDHLGLRTSVTFTGVRRALRVIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAA0</accession>
    <name>A0A0F7NAA0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alpha-mannosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_28200</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 38 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018709.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_28200"/>
    <dbReference type="EnsemblBacteria" id="AKH85475">
        <property type="protein sequence ID" value="AKH85475"/>
        <property type="gene ID" value="AA958_28200"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_28200"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5944"/>
    <dbReference type="OrthoDB" id="299689at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004559">
        <property type="term" value="F:alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041147">
        <property type="entry name" value="GH38_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011682">
        <property type="entry name" value="Glyco_hydro_38_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015341">
        <property type="entry name" value="Glyco_hydro_38_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037094">
        <property type="entry name" value="Glyco_hydro_38_cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000602">
        <property type="entry name" value="Glyco_hydro_38_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027291">
        <property type="entry name" value="Glyco_hydro_38_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028995">
        <property type="entry name" value="Glyco_hydro_57/38_cen_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09261">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17677">
        <property type="entry name" value="Glyco_hydro38C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07748">
        <property type="entry name" value="Glyco_hydro_38C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01074">
        <property type="entry name" value="Glyco_hydro_38N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00872">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88688">
        <property type="entry name" value="SSF88688"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-mann_mid" evidence="5">
        <location>
            <begin position="523"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH85475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="1044" mass="113619" checksum="773BD5FFEAE9A250" modified="2015-07-22" version="1">MHDDRLLAEGRLDRALRQFIRPAQYTERVPLELSVWHRPGEPVPADEALKIPPEEYEPFTVGTAWGPPWSTSWFRLTGAVPAGWAGRRVEAVIDPGFGTEMPGFQAEGLVYDAAGAPVKGVHPRNRHVPIASPAAGGEPVRLLLEAAANPAVLQDFTPTLLGQLRTAGDAPLYTFRSADLAVLNEDVWHLVLDIEVLSELMHELPVDRGRRHDILHTLDRMLDVLDLHDVPGTAAAAREVLAPALAQPASASAHRAYAAGHAHIDSAWLWPLRETVRKASRTFANVTELALSGDYPELVFACSQAQQYAWVKQHQPQIYERIRAAVQTGQFVPVGSMWVESDANMPGGEALARQLIHGKRFFAEEFGVDTQEVWLPDSFGYTAAFPQLARLAGIRWFLTQKLSWNQTNKMPHHTFWWEGIDGTRVFTHFPPVDTYNATMHASELSLAERNFADKGRASMSLVPFGYGDGGGGPTREMLEKARRLRSLEGSPRVEVADPAVFFAAAEEEYGAAAPVWSGELYLEFHRGTYTSQADTKSGNRRSEHLLREAELWATAAALADPAYAYPYEELDRIWKTVLLHQFHDILPGSSIAWVHREAAQTYAAVAEELAGITAAAVAALSTPGGDGVAVLNASPYDRGEVVELAAEEATALPPDAVTQPLGDGRSLARVDAPALGAGTAGAAAGAGVSAVRDGAQVVLDNGLLRVVVDGDGLVASVRDLTAGREVLAPGARANLLQLHPDHPNQWDAWDIDKFYRRTRTDLVDAESVEVTESGPLRAAVRVVRTTGRSRIVQDISLAAESGRVDFTTEVDWREEEKVLKAAFPLDVHADRSTSEIQFGHVHRPTHANTSWDAAKFEICAHRWLHVGEPGYGVAVLNDATYGHDVTREAHEAGLGTTVRLTILRAPKFPDPETDLGVHRYRYALLPGADVGAAVEQGLALNLPLRTARTAARAPLVSVSDPAITVESVKPAEDRSGDVVVRVYESRGGRASGTLTTSFAVGDVQVTDLLERPLDSSDATREEGGGVSLRLRPFQILTLRMRPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAI0</accession>
    <name>A0A0F7NAI0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Enoyl-CoA hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_22245</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017725.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_22245"/>
    <dbReference type="EnsemblBacteria" id="AKH84464">
        <property type="protein sequence ID" value="AKH84464"/>
        <property type="gene ID" value="AA958_22245"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_22245"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4685"/>
    <dbReference type="OrthoDB" id="1498685at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH84464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="259" mass="27437" checksum="F9F0E005F56679E0" modified="2015-07-22" version="1">MGEGIAVRTHEHVAELVLDRPEAMNAVSTELARALTETTARLAADASVRAVVLTSSHERAFCVGADLKERNAFTDADMHRHRPTSRAAYTGVLELPMPAIAAVHGFALGGGYELALSCDFIVADETAVVGLPEVSVGVVPGGGGTQLLPRRVGSARAAELIFTARRVEAAEAHELGLVDRLVPAGEARTTALDLARRIAGNSPVGVRAAKRALRLGHGRELRAGLEIEDAAWHRTALSADRKEGVAAFNEKRRPEWPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAU2</accession>
    <name>A0A0F7NAU2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glutamate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_26560</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the bacterial solute-binding protein 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018438.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_26560"/>
    <dbReference type="EnsemblBacteria" id="AKH85201">
        <property type="protein sequence ID" value="AKH85201"/>
        <property type="gene ID" value="AA958_26560"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_26560"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5589"/>
    <dbReference type="OrthoDB" id="685252at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018313">
        <property type="entry name" value="SBP_3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01039">
        <property type="entry name" value="SBP_BACTERIAL_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519915" evidence="4">
        <location>
            <begin position="23"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="PBPb" evidence="5">
        <location>
            <begin position="42"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH85201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="282" mass="29828" checksum="AD396D587D9781F7" modified="2015-07-22" version="1">MNLRKVSAAAACALALTVTAAACGSDDDSGDNGDGGGGGKDSITIGIKFDQPGLGLKEPDGSYSGFDVDVATYVAKELGYSEDQIEWKEAISADRETMLERGDVDMIAATYSITDERKQKVDFAGPYLLAHQDLLIRADDDITKGEDLNGKTLCSVTGSTSAQNVKDTIAPKAQLAERPGYSECLDAVANGQIDALTTDDSILAGYAAQEANKGKFKLAGLNLSNENYGVGIKKGDEKMKTDIDAALEKMVSDGSWEKFMDANLGPANYDFEPAPKIGDIKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAV2</accession>
    <name>A0A0F7NAV2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phage-shock protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_22855</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PspA/IM30 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017826.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_22855"/>
    <dbReference type="EnsemblBacteria" id="AKH84569">
        <property type="protein sequence ID" value="AKH84569"/>
        <property type="gene ID" value="AA958_22855"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_22855"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4813"/>
    <dbReference type="OrthoDB" id="941029at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007157">
        <property type="entry name" value="PspA_IM30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31088">
        <property type="entry name" value="PTHR31088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04012">
        <property type="entry name" value="PspA_IM30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="229"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH84569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="258" mass="28025" checksum="1A35DE34C1A0E9F8" modified="2015-07-22" version="1">MTGITKRIGDLFRIKANKALDRAEDPREVLDYSYQQQLEMLQKVRRGLADVATSRKRIELQADQLRQSTDKLEGQAQQALAVGREDLAREALTRRTTAASQIADLQDQQTALQAEEEKLTLASQRLQAKVDSFRTRKETIKATYTAAEAQTRITEAVSGVGEEMGDVGLAVQRAQDKTEQMQARAGALDELIDSGALEDATLPGGRDDIETELERVGADQDVEIELARMKAQLPAGSAPEEKGDPGAAGGGSDEEATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAX9</accession>
    <name>A0A0F7NAX9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Methylamine utilization protein MauE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AA958_23010</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be specifically involved in the processing, transport, and/or maturation of the MADH beta-subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">One-carbon metabolism; methylamine degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017851.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_23010"/>
    <dbReference type="EnsemblBacteria" id="AKH84594">
        <property type="protein sequence ID" value="AKH84594"/>
        <property type="gene ID" value="AA958_23010"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_23010"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4849"/>
    <dbReference type="UniPathway" id="UPA00895"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030416">
        <property type="term" value="P:methylamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009908">
        <property type="entry name" value="Methylamine_util_MauE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07291">
        <property type="entry name" value="MauE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="54"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="77"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="MauE" evidence="11">
        <location>
            <begin position="9"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AKH84594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="191" mass="19542" checksum="B143F847AB8D0557" modified="2015-07-22" version="1">MPAGQYLDLAIRVLLGVVFATALVSKLRPADFREFVETTGALLPAGLRPRRRPLGIAYLLCEAAIVLLVAVPPAVPAGMALAAGVLLVLAVAISRKERRGGHVLCRCFGAGTAPLGRPHLVRNVVLAGLAVTGLAANTLGPGGDVDSAAAVISAVAGGLFCALLVIRFDDLLSLFAPTPASRHQDPAGSGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NB16</accession>
    <name>A0A0F7NB16_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-methyladenine DNA glycosylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_23270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017895.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_23270"/>
    <dbReference type="EnsemblBacteria" id="AKH84639">
        <property type="protein sequence ID" value="AKH84639"/>
        <property type="gene ID" value="AA958_23270"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_23270"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4905"/>
    <dbReference type="OrthoDB" id="1835478at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008725">
        <property type="term" value="F:DNA-3-methyladenine glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005019">
        <property type="entry name" value="Adenine_glyco"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03352">
        <property type="entry name" value="Adenine_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH84639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="193" mass="20892" checksum="BFC58AFF0EF2B144" modified="2015-07-22" version="1">MSAEGGAVAGPDGLLRCPWGLSAEDYVAYHDEEWGRPVHGDDALFERLSLEAFQSGLSWLTILRRREGFRTAFAGFEIAAVAEFGPGDEQRLLADPGIIRNRLKVRATLANAKTLAAWTPGELDALIWSFAPDPAGRHAPRTLADVPAVTPESTALAKELKRRGVRFVGPTTAYALMQACGLVDDHLADCHAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NB29</accession>
    <name>A0A0F7NB29_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">UPF0056 membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_23345</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the UPF0056 (MarC) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017910.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_23345"/>
    <dbReference type="EnsemblBacteria" id="AKH84654">
        <property type="protein sequence ID" value="AKH84654"/>
        <property type="gene ID" value="AA958_23345"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_23345"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4921"/>
    <dbReference type="OrthoDB" id="1323133at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002771">
        <property type="entry name" value="Multi_antbiot-R_MarC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33508">
        <property type="entry name" value="PTHR33508"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01914">
        <property type="entry name" value="MarC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00427">
        <property type="entry name" value="TIGR00427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="67"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH84654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="201" mass="21267" checksum="BFAB7170F41E530C" modified="2015-07-22" version="1">MFDLALFGSVFVTLFVIMDPPGTTPIFLALTSGRPLKLQRKMAMQAAAVAFGVIAVFAFGGQQILDYLHVSVPALMVAGGLLLLLISLDLLTGKAEEPTQTKDVNAALVPLGMPLLAGPGAIVTVILAVQDAHGVRQELAVWAAIVAIHLVLWVTMRYSMLIIRVIKEGGVVLVSRLAGMLLATIAVQQIANGVTEFIQQA</sequence>
</entry>
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    <accession>A0A0F7NB32</accession>
    <name>A0A0F7NB32_9ACTN</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_18625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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    </dbReference>
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    </dbReference>
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        <property type="gene ID" value="AA958_18625"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_18625"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3906"/>
    <dbReference type="OrthoDB" id="2065888at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011024">
        <property type="entry name" value="G_crystallin-like"/>
    </dbReference>
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        <property type="entry name" value="SSF49695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519330" evidence="1">
        <location>
            <begin position="27"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="127" mass="13352" checksum="D3A25A6D28AB0DD2" modified="2015-07-22" version="1">MTKKLHAALVTAAAAAALLAAPGASAQAVADGYDRCPADHYCLFSGLDGTGDIVALQDDTPNLAAVGMDDRAKSDWNRTGYWINLWSDADYTGCMAVTSPGGKGNFFSSFRDFFSSVEIDEPNGMSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBP8</accession>
    <name>A0A0F7NBP8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cysteine desulfurase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_24535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AKH84849">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProt"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotran_5" evidence="1">
        <location>
            <begin position="39"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="484" mass="52223" checksum="9075584099D0E44A" modified="2015-07-22" version="1">MGRADTTGHVRERAADAPDLFAELREREFGYLDEGGHTYLDHTGAGLPPRSLVAESARRITGGLFGNPHSESPASRASGDRLAEAREAVLRYFNADPAEYAVIFTPNATGALRLVGEAYPLGRGSRLVLSLDNHNSVNGLREYARARGATVEYVPLRTPDMGIDEDRMHAALAVRTRRPALVRRAPRGLLAYPAQSNFTGVQHSLDWITTAQAHGYDIVLDAAAYVPTNALDLGRHHPDFTVVSWYKLFGHPTGLGALIARRTALAKLRRPWFAGGTIYAVSAQAQWHVLADDEAAFEDGTVNFLAIPDVTAGLAWIEDIGIDRVHDHVDALTAHLLAGLRTLRHGDGSPLVRVYGPDRAGAPRGGTVALNVLDAGGRVVDERVIIRDSGAYGISLRTGCFCNPGAGEAAFGLSPRRLRRAARRRLDSLEDYLKMLHLPSAGAVRVSLGASSQPADVETFLSFVTQTYRDRVPDAAGLAPRLGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NC21</accession>
    <name>A0A0F7NC21_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_20990</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017542.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH84257">
        <property type="protein sequence ID" value="AKH84257"/>
        <property type="gene ID" value="AA958_20990"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_20990"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4423"/>
    <dbReference type="OrthoDB" id="948454at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="2">
        <location>
            <begin position="7"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="2">
        <location>
            <begin position="74"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH84257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="246" mass="24686" checksum="C10F855FC10F1CED" modified="2015-07-22" version="1">MKLTVLGASGGTGREVVRQALAAGHEVTAVVRKEARSLAAVAGADPGGGAASGGKGRGAADGPGRGGQGGGRGRLTVMTVEDLTNPAALGPVVRGRDALLFCPGLPGGGRPTGRLGAAAHALVRAARAAGVRRLLVVSTAPVGPLPPDEGVLGRAVSPVLRTLFKDVYAEAAAMESELAHSGLDWTVLRPGKLTNRRGKGRYRRRVGGNVPGTGTLARADLARAVLDLMDDPAVRGRTVGLGSARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NC89</accession>
    <name>A0A0F7NC89_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Heat shock protein 90</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_25810</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 90 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018313.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_25810"/>
    <dbReference type="EnsemblBacteria" id="AKH85069">
        <property type="protein sequence ID" value="AKH85069"/>
        <property type="gene ID" value="AA958_25810"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_25810"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5436"/>
    <dbReference type="OrthoDB" id="246194at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001404">
        <property type="entry name" value="Hsp90_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020575">
        <property type="entry name" value="Hsp90_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11528">
        <property type="entry name" value="PTHR11528"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002583">
        <property type="entry name" value="Hsp90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00775">
        <property type="entry name" value="HEATSHOCK90"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0346">Stress response</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH85069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="622" mass="66834" checksum="ED7C13CCE22C67CA" modified="2015-07-22" version="1">MTSENAAPASSHTFQVDLRGLVDLLSHHLYSSPRVYLRELLQNAVDAVTARRAADPGAPDRIRLYPRDGGGAGLRVEDSGVGLTEAEVHELLATIGRSSKRAGGLESVRAGFLGRFGIGLLACFLVAERIRVVSRSAREPGAPPVEWTAAGDGSYTVRTLPPAARPEPGTTVYLTPRPGCAEWFEPARVAGLARDFGSLLPYDVRVDETPVTELPAVWDRPYPSPAARRVALAAHCRDVFGFTPLDAVELDVPLAGVRGVAYVLPSAVSPAQRAGHRVHLKGMLLTARAEGLLPDWAFFVRCVVDTDSLRPTASREALYEDETLLAVREALGGAVRDWLTSLATGDPDRLTQFLSVHHLGVKSLARHDEEMLRTMLPWLPFETTDGQVSLAEFAQRHPVVHFTRSVEEFRQVAPIASAQGIGVVNGGYTYDAELVELLPRVRPGTAVAELDPDTVTAHLDGVDAAEELALSGFLGVARARLDPLACDVVLRAFHPLTVPALHLDDRAARHERARADEEEQADELWADILGSLRGGAPRARLVLNHRSPLVRRISTLGAPELVGSAVEALYGQALLMAQRPLRPADSALLNRAFAGLLEWATHPPGAADPAAGAPGTGEEDGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCC7</accession>
    <name>A0A0F7NCC7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_32330</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019362.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_32330"/>
    <dbReference type="EnsemblBacteria" id="AKH86135">
        <property type="protein sequence ID" value="AKH86135"/>
        <property type="gene ID" value="AA958_32330"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_32330"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6825"/>
    <dbReference type="OrthoDB" id="1074175at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="68"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="105"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="69"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH86135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="272" mass="30802" checksum="F835B28F09E6E32C" modified="2015-07-22" version="1">MTARTYKTIAYVLLTVASLITVVPLLYTVSLSLQTEKEMLSAESVLWPESPQWGNYSTLFEEAPFGSFILNSLVVAGAIALSHLIFDPLVGYVFAKFDFPFKNTLFVAILATLMIPLFVRMIPLYVMMSDLGWLDSYQGLIVPFLMDGFGIFLMRQFIQPIPDDLIHAARVDGANEFTIYWRIILPQCKPALAVLGLFTFVFQWNEFLWPLVVTTSERMRTIPVGLTQFSQEQFQLWHLTAAGSVIMFVPTALLLIFSQRYFVRGIALTGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCK7</accession>
    <name>A0A0F7NCK7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Branched-chain amino acid ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_31140</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019159.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_31140"/>
    <dbReference type="EnsemblBacteria" id="AKH85931">
        <property type="protein sequence ID" value="AKH85931"/>
        <property type="gene ID" value="AA958_31140"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_31140"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6580"/>
    <dbReference type="OrthoDB" id="1179151at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="11"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="256"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="43"/>
            <end position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH85931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="277" mass="29087" checksum="756DB88783612245" modified="2015-07-22" version="1">MTASTTASTALELAGLTRRFGSLTAVDDVSLDLPAGARHALIGPNGAGKTTLLNLIAGTERPDQGSITFLGRDVTRTAPARRSRLGVARSFQQPTAVADLTVLDNVLLASWRHHPERRGAWRRSARRGRLAAAAAERLADVGLAGVADRPAGSLSHGQRRLLDLAAALVARPRVLLLDEPAAGLTDRDVVRLLDVLGSLDDDIAVLLVEHNTEVVARLARTVTVLVTGRVLASGRVREVFELPEVRSAYLDAAATADAPAPAGTPDAADAHDTGAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCL2</accession>
    <name>A0A0F7NCL2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_32910</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019452.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_32910"/>
    <dbReference type="EnsemblBacteria" id="AKH86225">
        <property type="protein sequence ID" value="AKH86225"/>
        <property type="gene ID" value="AA958_32910"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_32910"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6954"/>
    <dbReference type="OrthoDB" id="377638at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="16"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="430"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH86225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="529" mass="58236" checksum="BF6719B6F08487EE" modified="2015-07-22" version="1">MRNEALASLVLGDVLRERAETHRTETFLKFREGEVTYGEVDSMADRVAQGLATAGIDRGDHVGVMLPNCADFIHVIFALARLGAVAVPINVGYRGELLRHVLHSSDASALIIDAPYADRLPEVARHLPDLGRLIVRTEGASDVRLGALGKPAATLSSLLSNGVEAPRVDVGFGDLQAIMYTSGTTGPSKGAMIPHALALTCALDSLDFLDRWGKTTYCPLPLFHAAGLWDGVMSALLAGGAIAIVERFSASRFWDDVRLFDAQVAMSVFSMIPILLNQPRTERDKEHPLETFYMGKSSLDEPLWERFGVRSVETYTSTEVGIATASPYGEWRLGSCGQAHEERFEVAVVDEWDREVGADEPGELVVRPRQPFVITTGYYGAPEATADCFRNMWFHTGDRVWRDADGYFYFLDRMKDAIRRRGENISAFDLECEVNLHPSILESAAIGVPSELGDEDVKLAVVLQPGAALEPAELVAFCAERLPRSMVPRYIEFIDALPRTPTDKVAKYRLRAEGDHGLTPGTWDREETP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCQ6</accession>
    <name>A0A0F7NCQ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_26310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AKH85158">
        <property type="protein sequence ID" value="AKH85158"/>
        <property type="gene ID" value="AA958_26310"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_26310"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5539"/>
    <dbReference type="OrthoDB" id="1813824at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007546">
        <property type="entry name" value="DUF503"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036746">
        <property type="entry name" value="TT1725-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36441">
        <property type="entry name" value="PTHR36441"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04456">
        <property type="entry name" value="DUF503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103007">
        <property type="entry name" value="SSF103007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH85158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="98" mass="11031" checksum="FCCE893FB867113C" modified="2015-07-22" version="1">MYVGTLSCDFLLGDVRSLKEKRSVVRPIVAELIRKYAVTAAEVGHQDLHRRTVIGLAAISGDAGHLTDILDRCERMLAARPEVELLSVRRRIHHEDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCU7</accession>
    <name>A0A0F7NCU7_9ACTN</name>
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        <recommendedName>
            <fullName evidence="4">Fructose-1,6-bisphosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_22680</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>beta-D-fructose 1,6-bisphosphate + H2O = beta-D-fructose 6-phosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:11064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="EC" id="3.1.3.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the FBPase class 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017799.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_22680"/>
    <dbReference type="EnsemblBacteria" id="AKH84542">
        <property type="protein sequence ID" value="AKH84542"/>
        <property type="gene ID" value="AA958_22680"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_22680"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4771"/>
    <dbReference type="OrthoDB" id="879338at2"/>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042132">
        <property type="term" value="F:fructose 1,6-bisphosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01516">
        <property type="entry name" value="FBPase_glpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004464">
        <property type="entry name" value="FBPase_class-2/SBPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30447">
        <property type="entry name" value="PTHR30447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03320">
        <property type="entry name" value="FBPase_glpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004532">
        <property type="entry name" value="GlpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00330">
        <property type="entry name" value="glpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="109"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="186"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="208"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR004532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR004532-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR004532-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH84542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="348" mass="36971" checksum="7976672B3849D1BC" modified="2015-07-22" version="1">MSQSHETPHHLPEQLEVAPEAPDRNLALELVRVTEAGAMASGRWVGRGDKNGADGAAVRAMRTLVSTVSMNGVVVIGEGEKDHAPMLFNGERVGDGTGPECDVAVDPVDGTTLTAKGMGNAVSVLAVAERGCMFDPSAVFYMDKLATGPEAAEYVDINAPVAVNIRRVAKAKGGTTGDVTVCVLDRPRHDGLVQEVREAGARIKFISDGDVAGAIMTARDGTGVDLLLGVGGTPEAVIAACAMKCLGGTFQGRLWPRDDAERQRALDAGHDLDRTLLIDDLVSGENVFFVATGITDGELLRGVRYRADRAFTQSLVMRSKSGTIRQIESEHRLSKLRAYSSVDFDRAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCY0</accession>
    <name>A0A0F7NCY0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NocE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_27335</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018564.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_27335"/>
    <dbReference type="EnsemblBacteria" id="AKH85329">
        <property type="protein sequence ID" value="AKH85329"/>
        <property type="gene ID" value="AA958_27335"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_27335"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5760"/>
    <dbReference type="OrthoDB" id="51824at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01823">
        <property type="entry name" value="SEST_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037460">
        <property type="entry name" value="SEST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
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    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR37981">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
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    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519414" evidence="2">
        <location>
            <begin position="35"/>
            <end position="1346"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH_hydro" evidence="3">
        <location>
            <begin position="1033"/>
            <end position="1324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="416"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH85329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="1346" mass="142649" checksum="AE48614F44B4B2DA" modified="2015-07-22" version="1">MRNVRRGRRPLLPTAASLVVAAALSLPLALPALAAPAGPLPPASPAAAGPGGRPDRIAPADRPGVLGDGYRSSEDRAWTTSGDAAGFHVLVADAADGYRWRTAATLAEPGFEADAWIGNACVTESGDRAVVAYAPRTFTNDPELMSRGAFTAVVHLRTGEVTKLPVQASLAYFSPGCGAGERAVLAQFADESMAENSTRLIAVDAAAGRTAEPLTLDGQVTSAIPYGGDTIVAADGTRLVRIDERGRRAEIADTAATPFRLTRDAAGGIGYVDRPGRDARTGGTAGEVRFVPASAVSAAGRGGTRPEPRLVATGELTAFDLIGSASGEVYVTGEAGARGKAPAHLHNPGGLAKDAVPSTRGHAVVATGWADGGDSRSAAEDAVDVRAVTVDLTVPGTGKTARLGALPAAEPVARSAVASGRETSPALIGAGGTERGGTAASADPNDPVESERTCSVPRGDPRKQAFQPSPRQVEWAVDQAVIDGLDKWIDRPANWKNTGMEAYSPQELFPLRVLAGDPNGTVDRDDEWHIPAQILLGITAQESNMWQATRFAVPGVTANPLIGNYYGTNYASDGTQVDPWRINWADADCGYGITQVTDGMRLPGHGQPTLSEKQQEAAALDYTANIAAGADILAEKWNQTRSAGMTVNNGEPQWIENWFYALWAYNSGFYPESQADQNKGKWGVGWTNNPANPLWKANRLPFLESASGGDDYSHAAHPQDWPYQEKVLGWAGRPISALVEPGEFAAGYVGSWWNSHADRTAVKPPESLFCDASNECDPALIGPDDENDPGLGACEREDLYCWFNKSTAWKDCDLNAACGYPVHRFNNGDYPEQPDLNSYPPRCISGLPQGALIVDDLPDQAGSAGSSERQCAGFRSQGSFEFTFTEDEGQYPGKIDTHQIGAGYGNHFWFGHTRDTHDPQDTDGRRLATTGTWTLNRQLDGWARVLVHMPDHGAHTRQAAYVIEGTDSTSPVRVHPQRTRENRWVDLGVFRFTGTPKVSLGTDTADGNGSEDVAWDAVAFQPLPEKPADFVVAMGDSYSSGEGASASGGGDYLPETDWGGDQGDLRHACHRSTEAWSRQAALPGNGTSVGERVANWDETLDYHMTACSGATTDDFPVGGEGGYGELPQLAQGYLDQNTSLVMLSIGGNDARFSDIVDKCVRAFDECYRETLDGDDAPLEEAEPAYIRNQVKAAIVETLGAVRAEAPDAEVVLMGYPLLYSDSGSCLNYLGISGEEAAWMNEMGGVMNESMADAVTEANAASGETYAVFSDPTGAFEDKSICGDPEAVHGVVTDLTPGDDPMWDFGAFEGGISAQSFHPKIDGARLYANTLEQTLRERAGRAGAAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7ND16</accession>
    <name>A0A0F7ND16_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Squalene-hopene cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_32215</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis; hopanoid biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_32215"/>
    <dbReference type="EnsemblBacteria" id="AKH86116">
        <property type="protein sequence ID" value="AKH86116"/>
        <property type="gene ID" value="AA958_32215"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_32215"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6802"/>
    <dbReference type="OrthoDB" id="260889at2"/>
    <dbReference type="UniPathway" id="UPA00337"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016866">
        <property type="term" value="F:intramolecular transferase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:triterpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02892">
        <property type="entry name" value="SQCY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SQ_cyclase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032697">
        <property type="entry name" value="SQ_cyclase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018333">
        <property type="entry name" value="Squalene_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11764">
        <property type="entry name" value="PTHR11764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13243">
        <property type="entry name" value="SQHop_cyclase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01016">
        <property type="entry name" value="Prenyltransferase_Like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="SSF48239"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01507">
        <property type="entry name" value="hopene_cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01787">
        <property type="entry name" value="squalene_cyclas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="SQHop_cyclase_N" evidence="4">
        <location>
            <begin position="29"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="SQHop_cyclase_C" evidence="3">
        <location>
            <begin position="346"/>
            <end position="661"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH86116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="677" mass="73523" checksum="28E6402D69F2970D" modified="2015-07-22" version="1">MKATADGGNANDTAPAGAAASLLAARQAVERASANLLGRQDVEGWWKGDLETNVTMDAEDLFLREFLGVRDEHTTRAAARFIRGRQGAEGAWATFHGGPGDISATVEAYVALRLAGDAPDEEHMAQAAAWVRAHGGIAATRVFTRIWLALFGWWRWEDLPELPPELIYLPSWFPLNIYDFGCWARQTIVPLTVVSAKRPVHPAPFALDELHTDPAVPNPPRRQAPATSWDGLFQRLDRALHVYRKVAVRPLRKAALRSCARWIIERQESDGCWGGIQPPAVYSVIALNLLGYDLDHPVLKAGLESLDRFAVWTDAAEKPAADTGAASDTGDTRDDGPVRMIEACQSPVWDTCLATIALVDAGVPADHPQLVKAADWMLAEQVLATGDWSVRRPGLTPGGWAFEFHNDNYPDTDDTAEVVLALRRVAHPDQARVDAAVERAVRWLAGMQSKNGAWGAFDADNTSALPNKLPFCDFGEVIDPPSADVTAHVVEMLAGEKLGDDPHARRGVAWLLAEQEAAGGWFGRWGVNYVYGTGSAVPALVAAGLPTSHPAIRRAVSWLESVQNEDGGWGEDLRSYPDPQWIARGDSTASQTGWALLALLAAGEHDSAAVERGVAWLVRTQLPDGSWDEPQFTGTGFPWDFSINYHLYRMVFPLTALGRYLSATAGLTPAAGDGREV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDT9</accession>
    <name>A0A0F7NDT9_9ACTN</name>
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        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_33850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019613.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86391">
        <property type="protein sequence ID" value="AKH86391"/>
        <property type="gene ID" value="AA958_33850"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_33850"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.7148"/>
    <dbReference type="OrthoDB" id="1681849at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="155" mass="17500" checksum="412855CF702ED10B" modified="2015-07-22" version="1">MDATPRWLTPEQTAAWESFIRMQEKLIGRLSRRVQADSGMSAADYTVLVKLTESGEGRMRFMDLTKLVEWEKSRMSHQVGRMMKRGLVSKEDCPDDGRGAFIVATPAGYEAIEEAAPLHVAHVRRLFINALTEEELATLARISDRLLAHMEKQPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NE10</accession>
    <name>A0A0F7NE10_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP/GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_24900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018158.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_24900"/>
    <dbReference type="EnsemblBacteria" id="AKH84907">
        <property type="protein sequence ID" value="AKH84907"/>
        <property type="gene ID" value="AA958_24900"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_24900"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5249"/>
    <dbReference type="OrthoDB" id="2043725at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="108" mass="12179" checksum="13B80A72AD67B2C8" modified="2015-07-22" version="1">MSPRRNKPRSRGAARPSADDDLAGRIGTPDAADYGGEEYLVRRVAGSATDKSYRCPGCDQEIRPGTPHVVAWPEHRGADLRRHWHTACWNARDRRGTRPQRSRNAPRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NEA2</accession>
    <name>A0A0F7NEA2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">OmpR/PhoB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_30210</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AfsR/DnrI/RedD regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019012.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_30210"/>
    <dbReference type="EnsemblBacteria" id="AKH85784">
        <property type="protein sequence ID" value="AKH85784"/>
        <property type="gene ID" value="AA958_30210"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_30210"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6379"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15831">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03704">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH85784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="275" mass="30514" checksum="E0D0227B893270C8" modified="2015-07-22" version="1">MDIEVLGPLTVHLRGRLVLPTAPKPRKLLAMLALRADQVVPITVLIDELWGQNPPRSARTTMQTYVLQLRELIGEALELGGGDRGAAKDVLVTLPGGYRLETSGGSVDFREFDRRVAAGYRAFGAEDFHAAARLLRSALSLWTAPALADVQAGPYIRMEINRLEETRLGALDRRMEVDLRLGRHREVLSELTLLVNQHRTNESLHRQFMLALHRCGRPGEALSAYQRLRATLVEELGLEPSPQLQRLQRAIIASRGTQSPGRAVVEQPEAPARHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NEF0</accession>
    <name>A0A0F7NEF0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Single-stranded DNA-binding protein</fullName>
            <shortName evidence="2">SSB</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_09985</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
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        <property type="protein sequence ID" value="AKH86651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="entry name" value="Primosome_PriB/ssb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011344">
        <property type="entry name" value="ssDNA-bd"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ssb"/>
        <property type="match status" value="1"/>
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        <location>
            <begin position="143"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH86651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="167" mass="18233" checksum="1DC6DE37774C114B" modified="2015-07-22" version="1">MNETMVTVVGNAATSADYRTTQSGVPAVRFRLAATVRRFDQATGSWSDSYTNFFTVWAWRQLADNVAASVAIGEPLLVRGRLRVREYEKEGVRCTDPTIDATAVGHDLGWGTAAFRRVSRLRPSFADPARTDLDVAVRDALTPALEPGTPDAADREPRQPVLTPDLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NEF5</accession>
    <name>A0A0F7NEF5_9ACTN</name>
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        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_29955</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_29955"/>
    <dbReference type="EnsemblBacteria" id="AKH85748">
        <property type="protein sequence ID" value="AKH85748"/>
        <property type="gene ID" value="AA958_29955"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_29955"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6325"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="75"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="108"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="218"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="281"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH85748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="301" mass="33079" checksum="2E71EA41592DA0DE" modified="2015-07-22" version="1">MRYACVIRRFEFLPVILTVSFAPALLSAHEWSDVYSLNTLLGVLFSVSGMQIGNMTNALADREQDALYKSRQSEAIYGLGVSRVVAHIGVSTAINCVLAVFLAVRTGHWDLLPLAVFVGILGFQYSAPPLKLKGAGAWQLPTLQLSLVFLPGLFVLRSSEYAVEWGSVVALAGFALLLVSLFVTSHAEDYIEDEKFGIRTYTVAWGLKKTMYIQSSMLLVGSALFIVAVWATFGFSWAFVPWIAAWLVSQRLLYTVIRDVSDNTHEAAIEALHKKSLIGPYHAALMGWATVLLAVFVVIGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NEQ3</accession>
    <name>A0A0F7NEQ3_9ACTN</name>
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        <submittedName>
            <fullName evidence="8">Glutamate ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_26565</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018439.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_26565"/>
    <dbReference type="EnsemblBacteria" id="AKH85202">
        <property type="protein sequence ID" value="AKH85202"/>
        <property type="gene ID" value="AA958_26565"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_26565"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5590"/>
    <dbReference type="OrthoDB" id="1523519at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010065">
        <property type="entry name" value="AA_ABC_transptr_permease_3TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043429">
        <property type="entry name" value="ArtM/GltK/GlnP/TcyL/YhdX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01726">
        <property type="entry name" value="HEQRo_perm_3TM"/>
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    </dbReference>
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        <property type="entry name" value="ABC_TM1"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="15"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="15"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH85202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="223" mass="23690" checksum="73556BED539AB164" modified="2015-07-22" version="1">MDIISDYDTQILDAFWVTVKLTLLSGLFSLIWGTILAAMRVSPVPLMRGFGTVYVNVIRNIPLTVIIVFCALGLSDVFGVTLGAGIDFDSKFFRLAVLGLSAYTAAFVCEALRSGINTVPVGQAEAARAIGLSFTQVLGLIVLPQAFRSVVGPLTNVLIALTKNTTVAAAIGVAEAALLMKEMIENEAQLLLISAIFALGFLVLTLPTGLFLGWVGKKVAVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NEU7</accession>
    <name>A0A0F7NEU7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cellulose-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_22300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020324.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_22300"/>
    <dbReference type="EnsemblBacteria" id="AKH86965">
        <property type="protein sequence ID" value="AKH86965"/>
        <property type="gene ID" value="AA958_22300"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_22300"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4696"/>
    <dbReference type="OrthoDB" id="1005693at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004302">
        <property type="entry name" value="Cellulose/chitin-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03067">
        <property type="entry name" value="LPMO_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002520021" evidence="1">
        <location>
            <begin position="19"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-4" evidence="2">
        <location>
            <begin position="19"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH86965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="201" mass="22532" checksum="62F2CD27D850C9FB" modified="2015-07-22" version="1">MLVAVLAGALAWTSSAQAHGTVVDPATRAYHCWEEWGDDHLNPAMEQEDPMCWQAYQANPNTMWNWMSMLQDGLGGKFEERTPNGKLCSNNHQNFESLNNPGPWTTTDVTDNFSIHLYDQASHGADFFRVYVSKQGFDPKTQALGWDDLDFITETGSYPPASDITFPVQTSGYSGHHIVFTIWQASHLDQAYLMCSDVNFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NF18</accession>
    <name>A0A0F7NF18_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_27325</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CdaR family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018562.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_27325"/>
    <dbReference type="EnsemblBacteria" id="AKH85327">
        <property type="protein sequence ID" value="AKH85327"/>
        <property type="gene ID" value="AA958_27325"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_27325"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5758"/>
    <dbReference type="OrthoDB" id="469123at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041522">
        <property type="entry name" value="CdaR_GGDEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17853">
        <property type="entry name" value="GGDEF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGDEF_2" evidence="4">
        <location>
            <begin position="212"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_30" evidence="3">
        <location>
            <begin position="365"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_30" evidence="3">
        <location>
            <begin position="451"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="104"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH85327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="526" mass="56454" checksum="B8BB9EC775A4C93D" modified="2015-07-22" version="1">MQSPDVRDPHWRVARSDELLRETQRQAERPGEPDLRRICDWLCRHIDAHVALVWSTGTVAATSAGFPRAVLSALATRLPGLGGGRGVVAGLEAGGLHLRLEALEPQPRPADPRARPAAPGGGGTGPRPPRPVLVVASAAPLAREPALLASDTARSALLLLRLNEAAAVHRNYQHKARQVRFAVLQALLAGDPDLARRMTTGAVPELLDARTLRVYLLQCPPGERDRLALVLQDPSGYHDRDLMVQCPVIREHLICLVSEDSDDDRAPAGRGAELCRLAAGSAGYAVGISAVHALEDTSQAYEQARHALAVARNLPGAVASYRGESPLAQLLPRPEAVEWARSFLRPLAGAPRLTPQILRVGLTVSRSGAARFLDVSRNTVAAHFRRAERLLGLDLDEVTSRALLHLALALADPPPPATARTGTAPTVCELIRARPAAAWAAAFLHPLDDTLRTTARAWVAANANAQRTARDLGISRNTVRARLRTAEALLNRDLLTTGFGSYDLVHAFAIAEGRAAVVREGFLRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-08-12" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NF68</accession>
    <name>A0A0F7NF68_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_31440</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019211.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH85983">
        <property type="protein sequence ID" value="AKH85983"/>
        <property type="gene ID" value="AA958_31440"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_31440"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6643"/>
    <dbReference type="OrthoDB" id="1812435at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SSF49879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="3">
        <location>
            <begin position="38"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="207"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH85983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="258" mass="27626" checksum="D62C5CD2973D72DA" modified="2015-07-22" version="1">MSGRDSLARGVTPGQPGTLHARSATDGIEVAPLPGLTVRFGRGPGDEGAGGDVELHVGGRDQGVSRRHGELTCLEGGWTLRNTGQQALRLPRGRLLPPGSDRLPLTAGYTPVFVKGSGFREHLVELYVVRPEPVRPGDLAGAPPPAAWALSEDERLVLVVLGQRYLRHEPDPHPLPYRQTAEVMAFLRPGERWDAAEVARRVEDVRRRMPPAAGRSAVPDEEPPEPRGCTPDHRLLTDLVAATALVPPDLGLLDAAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFG4</accession>
    <name>A0A0F7NFG4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DeoR faimly transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_27975</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_27975"/>
    <dbReference type="EnsemblBacteria" id="AKH85437">
        <property type="protein sequence ID" value="AKH85437"/>
        <property type="gene ID" value="AA958_27975"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_27975"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5896"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014036">
        <property type="entry name" value="DeoR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00455">
        <property type="entry name" value="DeoRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08220">
        <property type="entry name" value="HTH_DeoR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00037">
        <property type="entry name" value="HTHLACR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00420">
        <property type="entry name" value="HTH_DEOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH85437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="241" mass="26084" checksum="BF46F0237F8D20EB" modified="2015-07-22" version="1">MDEGFVRIEQLADELGVTPMTIRRDLDHLQSRGWLRKVRGGATAQPSTAFHGDVRHRTQAMTAEKNALARAALPLVKSGQSVIIDDSTTALALTRLLTQQAPLTVITNFVPVTQVLAGSPGIELISLGGTYYPAYDAFLGLRTVDAVTSLYADTLFASTTAITRGHCYHQSQETVAVKRALMEACARKILLVDHTKFRRHGLYQLAPVTAFDLVIVDSGIPPADLDALQADGVEVLVAHPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFI5</accession>
    <name>A0A0F7NFI5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_25775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_25775"/>
    <dbReference type="EnsemblBacteria" id="AKH87036">
        <property type="protein sequence ID" value="AKH87036"/>
        <property type="gene ID" value="AA958_25775"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_25775"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5429"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021903">
        <property type="entry name" value="DUF3515"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12028">
        <property type="entry name" value="DUF3515"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519450" evidence="1">
        <location>
            <begin position="40"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH87036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="168" mass="17682" checksum="F73369625E49A76A" modified="2015-07-22" version="1">MHFRPTRPYRSALRLPAALLLLAAPLACSGGGGGTPQVAVPTPQGKAVDHCRALADRLPGTVDGQSRRETDPVSALTAGWGDPAVELRCGVPRPEVLTPGSEHYNPTADAVSVNGVDWLYEELDDGARFTTTQRRAFVEVTVPGAYAPEVNALTDLAEAVDKTVPGTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-10-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFK8</accession>
    <name>A0A0F7NFK8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_28260</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018721.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH85487">
        <property type="protein sequence ID" value="AKH85487"/>
        <property type="gene ID" value="AA958_28260"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_28260"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5956"/>
    <dbReference type="OrthoDB" id="1439158at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012914">
        <property type="entry name" value="PucR_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07905">
        <property type="entry name" value="PucR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PucR" evidence="2">
        <location>
            <begin position="6"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_30" evidence="3">
        <location>
            <begin position="550"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="389"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH85487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="609" mass="63318" checksum="E240CD61B3657A40" modified="2015-07-22" version="1">MRLRALLDSEALGLRLLGGADELDRTVRGVMTTDLTDPSRYLSGGELVLTGLAWRHGPQDSEPFVRILAAAGVAGLAAGEAELSGAGVPEDLVRACARHRLPLFAVDEDVAFATITEHVVRQVSGERAGDLAAVVERHRRLMSSGPAGGGPDVVLDLLGSDLDLRAWVLSPTGRQIAGTAAGAAGGRLPAQLRAQLAGEHLGALRGGRPGPHRVTLPAAGGGVTYSLFPVGGGRDLRETVLSDWLLAVEADAGEWPPERLDLVHGVTQLIAVERERRDAARSVRRRLAQEVLELVQAGAQPAEIAARLRVAVPVLLPGTGAAPQWQVVVARVEWEVPYGQPGIAGGPVAQAMLEEMLAGADRDPAERIAVAHTGDEAVALVPLPAVPARGAADGAPETGGADPGAGGGRSRKGAAEGAGTGRARSGGPSAVAGPGAAGGAAAGAGGLRAAALLAAVREPLARALADDGRLTLGISAAVDSPEGLRGALEEARHARRVAAARPGSVCAAGHEELASHVLLLPFVPDDVRRAFTARLLDPLRAYDHRHRAELVTTLEAFLDCDGSWTRCAARLHLHVNTLRYRVGRIEQLTGRDLARLEDKLDFFLALRMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NGA0</accession>
    <name>A0A0F7NGA0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LuxR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_00780</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019685.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86469">
        <property type="protein sequence ID" value="AKH86469"/>
        <property type="gene ID" value="AA958_00780"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_00780"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.176"/>
    <dbReference type="OrthoDB" id="1687028at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="15"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="173"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH86469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="251" mass="26443" checksum="16E64D6EC51FBECA" modified="2015-07-22" version="1">MGRQAEPGGADRAPRVLIADDQALVRTGFRMILAADGIDVVGEAADGEEAVAAVRRSLPDVVLMDIRMPGMDGLEATRRLLGADGRTAAGPAPGPGSGPGAPRVIILTTYDLDQYVYAALAAGASGFLLKDVTPEHLAAAVRLVRSGDALLAPSITRRLVERFATRDDRAVALHRDLSALTRRELEVLESLARGHSNAELAARFRLSEATVKTHVARILAKLQLRDRAQAVIAAYETGLITPGSAQPPPGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NGS1</accession>
    <name>A0A0F7NGS1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_09100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019893.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86634">
        <property type="protein sequence ID" value="AKH86634"/>
        <property type="gene ID" value="AA958_09100"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_09100"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1917"/>
    <dbReference type="OrthoDB" id="2056482at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH86634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="82" mass="9458" checksum="113C2F3958508CA6" modified="2015-07-22" version="1">MIERDLGIVKREFESCEDHQEQLRGIWGSGTVADAMEDFTTNWDRHRKEVLESVKSVGEMASSVHQSFLKTDKKLEQECKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NGX4</accession>
    <name>A0A0F7NGX4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_31435</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019210.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_31435"/>
    <dbReference type="EnsemblBacteria" id="AKH85982">
        <property type="protein sequence ID" value="AKH85982"/>
        <property type="gene ID" value="AA958_31435"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_31435"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6642"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="11"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="310"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="147"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH85982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="622" mass="67507" checksum="88754F54DD7100F0" modified="2015-07-22" version="1">MRVGQLVGDRYRLEELIGDEGRGEVWFAADEQLGRRVVLKRSGAIGERPRLLGVARAQAKATHPHVVTLYGVEFIESGPDAGCWLVMEHVTGGSLEKQPRMAPEKAARIGAQIASALAALHANGVVHCDVKPANVVITDDGTPKLTDFDSAQRTGSNETISPDRPLSYTPDYAAPEVVNGSPVPRSDVYSLAAMLYKVVTGVPHDEDDGEDDESTLREWKVSQGVLRRERDTGPLAGALEAMLRRRADRRPDATGARRLLQEAAGQRSWARRFGFPGAPRRHPRATAAAGTALVTAAAVAGAWFWWLSADGDDEPGGTPGGEKPRAGSVIGDQRTMDPCALTDPGEFDRFGTYVERDRDYGNFDRCDVLVYPQGEDGEHIDVQVEFDSGPAPESPAPVRTFGGIGIIEEPQQGDECARALVLPDEADRDVSIWIYVDGGAARDYGGVETLCDMADIAARTASETLGKARAEKRAVPRRDPPAPDVSLLWLDACRLLDARALEIVPGVDAGDPDVGFGNWDCDWYSTTRDIEVQLRYDRDQPLSGEDGRVTRLAGRDTVVSPGYDGEDTCTVRVEYREYPDENGQKAVELLYLTLDGDDESPDELCAMATRLAETAAGELPRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NHI1</accession>
    <name>A0A0F7NHI1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_32765</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86202">
        <property type="protein sequence ID" value="AKH86202"/>
        <property type="gene ID" value="AA958_32765"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_32765"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6923"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033456">
        <property type="entry name" value="DUF5132"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17195">
        <property type="entry name" value="DUF5132"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="79" mass="8116" checksum="F83D39E5E764DC5E" modified="2015-07-22" version="1">MVSAPLVKKAVRPVVRGTIKTSVKLAVDVKRAAHEINEDISDIAAEASAEAFAADVRGDADVPHAGAKKPRGGKAVATD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NHQ8</accession>
    <name>A0A0F7NHQ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD-dependent dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_22900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020337.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_22900"/>
    <dbReference type="EnsemblBacteria" id="AKH86974">
        <property type="protein sequence ID" value="AKH86974"/>
        <property type="gene ID" value="AA958_22900"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_22900"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4823"/>
    <dbReference type="OrthoDB" id="1928091at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021295">
        <property type="entry name" value="DUF2867"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11066">
        <property type="entry name" value="DUF2867"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="18"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="509" mass="55625" checksum="7AA01D500591294A" modified="2015-07-22" version="1">MDTVGQPAPESLTCLVAGASGYIGGRLVPELLAAGYRVRCLARTPGKLRDHPWAGDVEVVRGDVTDEESVGAALRGTDVAYYLVHALASGGGFEETDRRAARLFARQADAAGVRRIVYLGGLTPRGVPETSLSPHLRSRAEVGRIFLDGAVPATVLRAAVVIGSGSASFEMLRYLTERLPVMVTPRWVATRTQPIGIRDVLRYLVGSAAMPPDVDRAFDIGGPDVLTYREMMRRYAATAGLRKRLILPVPVLTPGLSSHWIGLVTPVPAAIARPLTESLRHEVVCREHDIARYVPDLPGRPLPFDEALALALRRVGEARIATRWSSAAVPGAPSDPLPTDPDWAGGSLYEDERQLSVDVPPDVLWKVIEAIGGDNGWYSFPLAWAVRGWLDRFAGGAGLRRGRRDAAHLRAGDSLDFWRVEEIEPGRLLRLRAEMRMPGLAWLEMYAEQDAAGRTRYRQRALFHPSGLPGHAYWWSVFPFHRVVFGGMARNITRAAARDAGVSPSGRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NHW8</accession>
    <name>A0A0F7NHW8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_27075</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_27075"/>
    <dbReference type="EnsemblBacteria" id="AKH87054">
        <property type="protein sequence ID" value="AKH87054"/>
        <property type="gene ID" value="AA958_27075"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_27075"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5700"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="116"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH87054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="340" mass="35731" checksum="59DAE6BB5A903149" modified="2015-07-22" version="1">MAIVAAVDTSAGPEVGYLPLVSLGPAFAGLVGGWRRTALIGALALLLCAALGQYNGLLGDRRGYTAMFSVVAVTAAGLVAVRMRQVREAELASVRSIAETAQRVLLRPVPRAAGNLRIALSYTSALADARIGGDLYEVVTSPAGVRVIVGDVQGKGLEAVEAAAVVLGAFREAAYDEPDLQAVGKRVELALERQLPSEKFVTAIMAEIGDTPAVTLLNYGHPAPLAVNSSGDARLLDPPARALPLGLGMHGATPPQPHVHPFSPGDQILFYTDGVTEARNERGAFYPLTQCTAHLMDTDADTALAAIRQSLVDHVRGPLQDDAAMLLLRYRKDDTDAQQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NI79</accession>
    <name>A0A0F7NI79_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chemical-damaging agent resistance protein C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_30890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020586.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_30890"/>
    <dbReference type="EnsemblBacteria" id="AKH87159">
        <property type="protein sequence ID" value="AKH87159"/>
        <property type="gene ID" value="AA958_30890"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_30890"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6528"/>
    <dbReference type="OrthoDB" id="1437267at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd06974">
        <property type="entry name" value="TerD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003325">
        <property type="entry name" value="TerD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02342">
        <property type="entry name" value="TerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TerD" evidence="1">
        <location>
            <begin position="1"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH87159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="192" mass="20219" checksum="F0B339D1E3552AD2" modified="2015-07-22" version="1">MGVSLAKGGNVSLSKEAPGLTAVTVGLGWDVRTTTGAAHDLDASALMCGASGKVLSDQHFIFYNNLTSPDGSVEHTGDNLTGEGDGDDESINVDLSLVPPQVEKIVFPVSIHDADLRGQNFGQVSNAFIRVVNRSDGVELVRFDLSEDASTETAMVFGELYRRAGEWKFRAVGQGYASGLHGIATDYGVNVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NIL0</accession>
    <name>A0A0F7NIL0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PaaX family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_29235</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020504.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH87108">
        <property type="protein sequence ID" value="AKH87108"/>
        <property type="gene ID" value="AA958_29235"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_29235"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6163"/>
    <dbReference type="OrthoDB" id="1210594at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012906">
        <property type="entry name" value="PaaX-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013225">
        <property type="entry name" value="PaaX_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011965">
        <property type="entry name" value="PaaX_trns_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07848">
        <property type="entry name" value="PaaX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08223">
        <property type="entry name" value="PaaX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF020623">
        <property type="entry name" value="PaaX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PaaX" evidence="1">
        <location>
            <begin position="2"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="PaaX_C" evidence="2">
        <location>
            <begin position="161"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH87108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="259" mass="29284" checksum="C34A02687C515D9C" modified="2015-07-22" version="1">MLTFLGNYVLGRDIAVFSGSFIDVFARLGVGEHALRSTLTRMVGRDLLARHRRGRRMYFGLTERSAEILRDGETRVWQRGAVNADWDGTWTVLAFSLPESWQRQRHDLRARLVWAGFGTLGNGMWIAPSGVDVSRIVSSPELAGRVKVFSGTAQPPTDVGQMVRQAFDLDGLVAGYSDFLLRWDMPDPFPDAPDDLARYLRLLTEWLQLVRMDPRLPVQHLPADWPAARAQDVVHRLRSRYEGPAREIADRACEIVELG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NJL9</accession>
    <name>A0A0F7NJL9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_23195</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020348.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_23195"/>
    <dbReference type="EnsemblBacteria" id="AKH86982">
        <property type="protein sequence ID" value="AKH86982"/>
        <property type="gene ID" value="AA958_23195"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_23195"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4890"/>
    <dbReference type="OrthoDB" id="1734230at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025966">
        <property type="entry name" value="OppC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12911">
        <property type="entry name" value="OppC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="94"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="132"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="162"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="220"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="270"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="90"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH86982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="305" mass="33093" checksum="8470D9752699F7B6" modified="2015-07-22" version="1">MWQRFKRDRAGVISAYVVGFFVLVAIFAPLIAKLYGKSPYTLYNSATGKPELFDALGYPIKPNGGISGEFWFGLEPILGRDVFTLLIYSIRTSLAIAVAVTVLTVGIGVLLGVAAGFTGGRTDTLIGRFTDLMLAFPSQLFFVAFMPVITAMFVAPEDATPTWLRVAVLIGVLAALNWMRMARIVRGVALSMREREFVEAAKVSGASNWRIIRKEMLPNLVTPILVQGTFELPLVVTNAAGLSFLGVGLVNPTPDWGLMFARAADVSETVPTFMFFPGVAIVIFVVAFNLLGDSVRDAFDPKAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NJT5</accession>
    <name>A0A0F7NJT5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-(apurinic or apyrimidinic site) lyase</fullName>
            <ecNumber evidence="3">4.2.99.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">AA958_26495</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPG family.</text>
    </comment>
    <dbReference type="EC" id="4.2.99.18" evidence="3"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020426.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_26495"/>
    <dbReference type="EnsemblBacteria" id="AKH87047">
        <property type="protein sequence ID" value="AKH87047"/>
        <property type="gene ID" value="AA958_26495"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_26495"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5576"/>
    <dbReference type="OrthoDB" id="1162346at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019104">
        <property type="term" value="F:DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08971">
        <property type="entry name" value="AcNei2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015886">
        <property type="entry name" value="DNA_glyclase/AP_lyase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015887">
        <property type="entry name" value="DNA_glyclase_Znf_dom_DNA_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012319">
        <property type="entry name" value="FPG_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035937">
        <property type="entry name" value="MutM-like_N-ter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044090">
        <property type="entry name" value="Nei2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_S13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000214">
        <property type="entry name" value="Znf_DNA_glyclase/AP_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010663">
        <property type="entry name" value="Znf_FPG/IleRS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01149">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06831">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06827">
        <property type="entry name" value="zf-FPG_IleRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00898">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01232">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="SSF46946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81624">
        <property type="entry name" value="SSF81624"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51068">
        <property type="entry name" value="FPG_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01242">
        <property type="entry name" value="ZF_FPG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51066">
        <property type="entry name" value="ZF_FPG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FPG_CAT" evidence="17">
        <location>
            <begin position="2"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="FPG-type" evidence="16">
        <location>
            <begin position="222"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00024490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="AKH87047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="262" mass="28857" checksum="770C0A513EF21FD7" modified="2015-07-22" version="1">MPEGDTVWRTARLLHAALAGRRLTRCDLRVPKLATADLTGREVTEVVPRGKHLLTRVEGGLTLHSHLRMEGAWITYADGERWRGGPGHQIRAVLGNADRTAVGYRLPVLELLRTAAEDRIVGHLGPDLLGPDWDPAEAERRLLADPARPLGDALLDQRNLAGIGNVYKSELCFLAGVSPYAPVAALPEPARLVAAARRLLEANRDRVARTTTPSRRPDRRLWVYGRGGRPCLRCGTAVRKRAQGETADERVTYWCPRCQPGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MXD6</accession>
    <name>A0A0F7MXD6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
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        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="AA958_00500"/>
    </dbReference>
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    <dbReference type="PATRIC" id="fig|444103.5.peg.116"/>
    <dbReference type="OrthoDB" id="2040145at2"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0016021">
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    </dbReference>
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            <end position="60"/>
        </location>
    </feature>
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        <location>
            <begin position="64"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH80895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="103" mass="10954" checksum="4327284CFFE50BDC" modified="2015-07-22" version="1">MKIFGWLLFVCGLYFLVQGFAMPMIAERSDVESIEFQQIRESSSYLGIGLMIGAVACGVLDRGPGGSTRHAAQQPPAYPAQQPYGAPPPPQQPHGGWGPPPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MXL2</accession>
    <name>A0A0F7MXL2_9ACTN</name>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_01030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
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            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000034283">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="AKH80985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="78" mass="8122" checksum="9C89D17698B2DC82" modified="2015-07-22" version="1">MIQFHRLLYTPGTGAGAAVRGGQDDGVVRLTERAAQRLTVPHELRVLPGATHLFPQQGALAEVGAAAAGWFTQTASVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N089</accession>
    <name>A0A0F7N089_9ACTN</name>
    <protein>
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            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="6" type="ORF">AA958_34125</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="AKH86433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014205.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_00130"/>
    <dbReference type="EnsemblBacteria" id="AKH80838">
        <property type="protein sequence ID" value="AKH80838"/>
        <property type="gene ID" value="AA958_00130"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86433">
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        <property type="gene ID" value="AA958_34125"/>
    </dbReference>
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    <dbReference type="PATRIC" id="fig|444103.5.peg.29"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
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            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="4">
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            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
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            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH80838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH86433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="274" mass="29071" checksum="E6DE74102D7EA975" modified="2015-07-22" version="1">MSDDEVRPKLQRAGAVKSPIQTIDRVAALLEAVAGAGPAGIALTQATDAVGLRASTGRTLLSALVMHGLVVQIESSRRYVLGPRFFELNRTYTLQNDLGAVAAPVLRELWETSQETVQLATLQHGRRVDVSVLVGPQLLNINPTTMRSASEPVEPLIHTAAGKVLLAGLPEAERDRLLASGRTAFDRETVLAELTAVAERGVATNHEEEVTGVCGIAAPVRDHSGRVVAALCLGYPSARRSPAYEERLRAATTASAAELSVLLGAPDDERGHRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0F9</accession>
    <name>A0A0F7N0F9_9ACTN</name>
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        <submittedName>
            <fullName evidence="7">Amino acid permease</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
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        <lineage>
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    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="AKH80888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_00465"/>
    <dbReference type="EnsemblBacteria" id="AKH80888">
        <property type="protein sequence ID" value="AKH80888"/>
        <property type="gene ID" value="AA958_00465"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_00465"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.109"/>
    <dbReference type="OrthoDB" id="527053at2"/>
    <dbReference type="Proteomes" id="UP000034283">
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    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
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        <location>
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            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="217"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="264"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AKH80888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="512" mass="54371" checksum="28F73EEC64521066" modified="2015-07-22" version="1">MADVEARPPGAEPARQDGGPPPQRMARELGWYASFSVAFGFVSIATGIFTTYGAVLSTSGPRGIWAWPISVVGQLSIALVFGALAARIPISGYSYQWVSRIVGPVWGWIMGWVSFAFLGVVLVAVDYTIASTILPELFQYVGTTQNAWVITAVVVLLQAVLVAASTRFTHRVNSTAVTVQLIGMIALTVLLFVVGALTGKLDFGHLFEAGPVPESGYYALGGATEAGPFALAFLLGAFTIVGFESAANLAEETKNPAHVIPRAMVQAVISLGVLGLLFLIAITAAAGRVHGVGASDTPVATVITAVLGSVVGKILLVLVVISIFSCGLVITLSGTRLVYAMSRDERFPGWQLLRRIHPRTATPLNASVFMMLVAQIILAVFSQSTDALFELFSAGTLLPALIYAGTVAMYAAKRRSLPPSRGFTLGRWEIPVLVVAAVWLVYELLIFRDASFRAPWIYVLVLFAIGAVYFAGLLLRSGRAGLTMPDLADVDRSLDTADTAIPRPKAAEGNAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0H3</accession>
    <name>A0A0F7N0H3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pup--protein ligase</fullName>
            <ecNumber evidence="2">6.3.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Proteasome accessory factor A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Pup-conjugating enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">pafA</name>
        <name evidence="4" type="ORF">AA958_03980</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + [prokaryotic ubiquitin-like protein]-L-glutamate + [protein]-L-lysine = ADP + phosphate + N(6)-([prokaryotic ubiquitin-like protein]-gamma-L-glutamyl)-[protein]-L-lysine.</text>
            <dbReference type="EC" id="6.3.1.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein degradation; proteasomal Pup-dependent pathway.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein pupylation.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="2">The reaction mechanism probably proceeds via the activation of Pup by phosphorylation of its C-terminal glutamate, which is then subject to nucleophilic attack by the substrate lysine, resulting in an isopeptide bond and the release of phosphate as a good leaving group.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Pup ligase/Pup deamidase family. Pup-conjugating enzyme subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.19" evidence="2"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018836870.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_03980"/>
    <dbReference type="EnsemblBacteria" id="AKH81486">
        <property type="protein sequence ID" value="AKH81486"/>
        <property type="gene ID" value="AA958_03980"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_03980"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.835"/>
    <dbReference type="OrthoDB" id="537546at2"/>
    <dbReference type="UniPathway" id="UPA00997"/>
    <dbReference type="UniPathway" id="UPA00998"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016879">
        <property type="term" value="F:ligase activity, forming carbon-nitrogen bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019787">
        <property type="term" value="F:ubiquitin-like protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019941">
        <property type="term" value="P:modification-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070490">
        <property type="term" value="P:protein pupylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02111">
        <property type="entry name" value="Pup_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022279">
        <property type="entry name" value="Pup_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004347">
        <property type="entry name" value="Pup_ligase/deamidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42307">
        <property type="entry name" value="PTHR42307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03136">
        <property type="entry name" value="Pup_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018077">
        <property type="entry name" value="UCP018077"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03686">
        <property type="entry name" value="pupylate_PafA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="active site" description="Proton acceptor" evidence="2 3">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="420"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR018077-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH81486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="453" mass="51995" checksum="00194F9B1EAA1BC3" modified="2015-07-22" version="1">MDRRIFGLENEYGVTCTFRGQRRLSPDEVARYLFRRVVSWGRSSNVFLRNGARLYLDVGSHPEYATPECDNVIELVTHDKAGERILEGLLVDAERRLHEEGIAGDVYLFKNNTDSAGNSYGCHENYLVARHGEFSRLADILIPFLVTRQLICGAGKVLQTPRGAVYCVSQRAEHIWEGVSSATTRSRPIINTRDEPHADAERYRRLHVIVGDSNMSETTMLLKVGATDLVLRMIEAGTVMRDLTLENPIRAIREVSHDMTGQRKVRLASGREASALEVQQEYYEKAVDFVDRRGIRTGVVEQVLELWGRTLEAIRSQDLAKVGTEIDWVMKHQLIERYRAKNNITLSHPRIAQIDLAYHDIHRRRGLYYLLEKRGQAARVCNDLKIFEAKSVPPQTTRARLRGDFIRRAQEQRRDFTVDWVHLKLNDQAQRTVLCKDPFRSVDDRVEKLIAGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0L5</accession>
    <name>A0A0F7N0L5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FMN_red domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_04205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014881.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_04205"/>
    <dbReference type="EnsemblBacteria" id="AKH81526">
        <property type="protein sequence ID" value="AKH81526"/>
        <property type="gene ID" value="AA958_04205"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_04205"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.882"/>
    <dbReference type="OrthoDB" id="1818437at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN_red" evidence="1">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="184" mass="19413" checksum="CDEA7B4E5924AB25" modified="2015-07-22" version="1">MRILGLCGSLRSGSFNASVLRTAVDMTVSPRELVVWPDLGRLPFFNADVEQTALPGIVADLRSAVGLSDGVLIVSPEYAHGTSGVLKNALEWLVGGGEIAAKPVALVSASTAITGGDNARSWLSQTLTVMGAQVIPQDLRIPIATRKITDGRLTDEPTLAALHDLLDHLTDAAVKAREENDTYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0U7</accession>
    <name>A0A0F7N0U7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HxlR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_04770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014976.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_04770"/>
    <dbReference type="EnsemblBacteria" id="AKH81621">
        <property type="protein sequence ID" value="AKH81621"/>
        <property type="gene ID" value="AA958_04770"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_04770"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1005"/>
    <dbReference type="OrthoDB" id="2057904at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="1">
        <location>
            <begin position="14"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="133" mass="14849" checksum="9F82EDA24F11964F" modified="2015-07-22" version="1">MSEPLRPDMFDELCPSSVLPFRFGDKWGGLILACLEGGPRRYSELRVPLRRVTPKMMTRSLRSLERDGLVARTVYEGPPQRVEYALTPLGRSMLEPLRAACAWAAEHWDELLDAREAYERRSGTAEAAGAAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0W1</accession>
    <name>A0A0F7N0W1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">TNT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_08455</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015608.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_08455"/>
    <dbReference type="EnsemblBacteria" id="AKH82260">
        <property type="protein sequence ID" value="AKH82260"/>
        <property type="gene ID" value="AA958_08455"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_08455"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1785"/>
    <dbReference type="OrthoDB" id="155126at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061810">
        <property type="term" value="F:NAD glycohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025331">
        <property type="entry name" value="TNT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14021">
        <property type="entry name" value="TNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519051" description="TNT domain-containing protein" evidence="2">
        <location>
            <begin position="31"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="TNT" evidence="3">
        <location>
            <begin position="146"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH82260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="249" mass="26398" checksum="D48F4523AD218086" modified="2015-07-22" version="1">MTRTRTVRTALAVLVAAAGLAGGVPAAAGAAGHPDPATRPSVLHPPATGRAAPVPAPAVGASSRAAPVCTGERFGDARLGPEHLPGRWEPRVGPLLQGWHPTGSLTPAAFLDKYWTGPAEGGTWKYPPNDGFAEVNGTVDREATRLEAGQLLDRFGSEYGGYLAPAGDRYAERALPPQNLNTRDPDAPCDYRVYQVTKPFRVWQGAVAPWFEQPGGGEQIKLDPVFLDPGEGQRLNVTWLLEHGYLAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0W5</accession>
    <name>A0A0F7N0W5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Prolyl-tRNA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_01150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014369.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_01150"/>
    <dbReference type="EnsemblBacteria" id="AKH81004">
        <property type="protein sequence ID" value="AKH81004"/>
        <property type="gene ID" value="AA958_01150"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_01150"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.253"/>
    <dbReference type="OrthoDB" id="1935578at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004812">
        <property type="term" value="F:aminoacyl-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.960.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036754">
        <property type="entry name" value="YbaK/aa-tRNA-synt-asso_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007214">
        <property type="entry name" value="YbaK/aa-tRNA-synth-assoc-dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04073">
        <property type="entry name" value="tRNA_edit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55826">
        <property type="entry name" value="SSF55826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA_edit" evidence="1">
        <location>
            <begin position="62"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="184" mass="18739" checksum="41A4365026DE37DA" modified="2015-07-22" version="1">MRAPIGAFDDAAPATERLDLLADPVAAALRGWQGAVPAAELVHVDSDPELADTAVFCEAYGQELLEQSANCVVVAGKRGGNVTLAACVVLSTTRVDVNGTVRRHLGVRKASFAPAGTATAETGMEYGGITPVGLPESWPVLVDARVADTPHLVVGSGRRRGKLIVPGKALAGLPGAVVLDGLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N101</accession>
    <name>A0A0F7N101_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_05110</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015031.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_05110"/>
    <dbReference type="EnsemblBacteria" id="AKH81676">
        <property type="protein sequence ID" value="AKH81676"/>
        <property type="gene ID" value="AA958_05110"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_05110"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1074"/>
    <dbReference type="OrthoDB" id="1875458at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="5">
        <location>
            <begin position="9"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="96"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH81676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="227" mass="24251" checksum="F7FB126EC9C473E2" modified="2015-07-22" version="1">MALTSPRRSSLTDQVIAQLRTQITAGEWPVGSRIPTEPELVEQLGVARNTVREAVRALANNGLLDIRQGSGTYVAATSELAGVMQRRFADARPAHVAELRSALEAQAARLAAVRRTEAEMTQLELLLRRREEAWESGDAAAFVDADATLHLAVATASHNEVLTAVYADLGEVVRTTLRSKVGDVLLPAEHLDHARMVTAIRAGDAETAAEEAASHAYGCMPEPALGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N196</accession>
    <name>A0A0F7N196_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AA958_02065</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M48 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014518.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_02065"/>
    <dbReference type="EnsemblBacteria" id="AKH81154">
        <property type="protein sequence ID" value="AKH81154"/>
        <property type="gene ID" value="AA958_02065"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_02065"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.445"/>
    <dbReference type="OrthoDB" id="1707650at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="89"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M48" evidence="8">
        <location>
            <begin position="144"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH81154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="313" mass="33724" checksum="C5500FB9878D1F19" modified="2015-07-22" version="1">MVIPLTLLAFAVLVAAVAPRLLTRAAWADREPVLALWVWQCVVAAVLLCCGLAMSLSAAVAWAQVHSGVFAPAPAAVRDAYGDATGATWAAVLAVGLAAGGLWTAVMFVREVRTARVQRRRRREELRRRAPLLPGEDAGAERLVVLEGERPDAWWLPGGQAAQLIITTAALRRLKKRQLDAVLAHEQGHSRARHHWLRHCAGALAGVPSFPVFRAFRDEVHRLCELAADDVASRRFGRMTFATALVELNEERGVFGPGPGHGHHAHLPQRVDRLLAAAPRFTPARRLRLTVAALAAPAVPLLVAFGPGLSALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N1G8</accession>
    <name>A0A0F7N1G8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate carboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_02860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_02860"/>
    <dbReference type="EnsemblBacteria" id="AKH81288">
        <property type="protein sequence ID" value="AKH81288"/>
        <property type="gene ID" value="AA958_02860"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_02860"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.612"/>
    <dbReference type="OrthoDB" id="1744359at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039476">
        <property type="entry name" value="P2CMN_synthase_LarB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000031">
        <property type="entry name" value="PurE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43064">
        <property type="entry name" value="PTHR43064"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00731">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01001">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIRC" evidence="1">
        <location>
            <begin position="112"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="245" mass="24628" checksum="F97570A97B1DCC33" modified="2015-07-22" version="1">MSEPRGSALDPTGLAGLLSGGVAEVGDFARLDVGRRRRTGVPEVVYADGKTPQQTLQLLAELRLRAPDSPALATRCPEEVLRDAPDTFADEPVRVDTRARTVTVGPLPAPRGTVAVLTAGTSDLPVAREAVATLDALGTGSRLYADVGVAGLSRLLSVLAEVRAADCAIVVAGMDGALPSVVTGLLTTPVVGVPTSVGYGFADGGRAAAGAMLASCAPGLTVVNIDNGFGAAVHAAKIVGVRAGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N1N1</accession>
    <name>A0A0F7N1N1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sugar ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_09845</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015827.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_09845"/>
    <dbReference type="EnsemblBacteria" id="AKH82485">
        <property type="protein sequence ID" value="AKH82485"/>
        <property type="gene ID" value="AA958_09845"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_09845"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2074"/>
    <dbReference type="OrthoDB" id="1303718at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519067" evidence="1">
        <location>
            <begin position="36"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="448" mass="48115" checksum="3D30772A3C8E72AF" modified="2015-07-22" version="1">MPTTRPRGRAVAAVAAAAALSLFAAACTGGNDSGAANDDPDADVTLTFWHGWSAPSEVEAIEANIDAFEEKFPNITVKSVKGVNDDKLNQGLRAGGSNGPDVVSSFTTDNVGRFCSSHVLADLDPFLKKSGISPEETFPAPMLEYTQYEGKRCALPLLGDAYGLYYNKDAFAEAGIDAPPKTLSELEEVAKKLTKPDGDGYEQLGFMPNFQGYETTVEHYGGQFGLTYFDDEGKSNAAADPRMAELFEWQKGMVDALGGFGKLRKYRNTFGDEWGPKHPFHTGQVAMQMDGEWRGKMAADAGVGFEIGAAPFPVPDDQADSYGKGYLSGTITGIATTSEKKNAAWELVKYLTTDTGAVVDFANAIHNVPSTLAALKSPKLNDDPVYRTFVDIAQHPGSSHAPPSKNGGAFLLTLQDYGLKYEKGEEDDLRSLLEQADEQIDKDNAQAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N1R5</accession>
    <name>A0A0F7N1R5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cupin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_10160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015872.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_10160"/>
    <dbReference type="EnsemblBacteria" id="AKH82530">
        <property type="protein sequence ID" value="AKH82530"/>
        <property type="gene ID" value="AA958_10160"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_10160"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2139"/>
    <dbReference type="OrthoDB" id="1593544at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH82530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="242" mass="25464" checksum="BEE01DCC72DADADD" modified="2015-07-22" version="1">MADPALPPLPGGVSVSRLRVYDWQAPDGLRGGTPHLHLACTEAYVVLGGHGAVQTLTASGYAETELVEDAVVWFTPGTIHRLVNADGRLDILVLMQNAGLPEAGDAVFPFPSDVLYDDAAYARAAALDPAEPEKSAQARRDLALAGFAELAGAARAGDPAPLEAFHARAVELVRPHLDNWRERWERGPSAAAAATDAHLTALRTDGAHLRSASVQRTGAESRYGMCGRLQACDLDGAVTVGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N270</accession>
    <name>A0A0F7N270_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptidase S41</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_11145</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S41A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016033.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_11145"/>
    <dbReference type="EnsemblBacteria" id="AKH82695">
        <property type="protein sequence ID" value="AKH82695"/>
        <property type="gene ID" value="AA958_11145"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_11145"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2348"/>
    <dbReference type="OrthoDB" id="1646508at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07560">
        <property type="entry name" value="Peptidase_S41_CPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004447">
        <property type="entry name" value="Peptidase_S41A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005151">
        <property type="entry name" value="Tail-specific_protease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03572">
        <property type="entry name" value="Peptidase_S41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00245">
        <property type="entry name" value="TSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="PDZ" evidence="4">
        <location>
            <begin position="70"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH82695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="371" mass="38152" checksum="403DB2519590DFA4" modified="2015-07-22" version="1">MVFVSVLATGAATGSWPGEAERPPKVLTGHVADEQDYEPRAGGGGTAGSAGELVSRSGDRWSTAYSAREYESLQQMLAGKYVGVGLWIKTDGAGRMEIAQVGEDSPAAEAGIRAGDTLRAVDGTPVAGRPVTEVVALLRGEELGEGARGSTVVLALQRGERRWTRPVRRVELTTEPVTVRHDRPGGEGAATPVIRVESFTRGSGAEVRRAAAEARGSDGLILDLRGNSGGLVVEAVEAASGFLDDGVVATYDMEGSQQVLYAKPGGNTRTPMVVLVDGGTMSSAELLAGALQDRGRAVVVGSRTFGKGSVQMPKALPDGSVAELTVGEYRTPAGRSLEGVGVTPDLDLAVAGGRSAEEEARTVLSGLGSGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2S9</accession>
    <name>A0A0F7N2S9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_12480</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016250.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_12480"/>
    <dbReference type="EnsemblBacteria" id="AKH82915">
        <property type="protein sequence ID" value="AKH82915"/>
        <property type="gene ID" value="AA958_12480"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_12480"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2622"/>
    <dbReference type="OrthoDB" id="807474at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005693">
        <property type="entry name" value="Mce"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024516">
        <property type="entry name" value="Mce_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11887">
        <property type="entry name" value="Mce4_CUP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00996">
        <property type="entry name" value="Mtu_fam_mce"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519185" evidence="2">
        <location>
            <begin position="24"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="MlaD" evidence="3">
        <location>
            <begin position="42"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Mce4_CUP1" evidence="4">
        <location>
            <begin position="121"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF11887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH82915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="343" mass="36905" checksum="A7CCAEF6562F66A4" modified="2015-07-22" version="1">MNRRSLAGPLIKSLVFVAVTALATTALAFSIANTGVGPTDGYSARFTDVTGLVEGDSVRVAGVKVGEVESIELSGRRYARVEFTVREGRELPASVNASVKYLNMVGQRYIDLEQGEGPVGRSLAPGGTIPLERTRPALDLTELFNGFQPLFQGLSPRDTNKLANEIVQVLQGQGGTVDSLVETVGSLTGTLAAKDQVIGEVIDNLTEVVETVNTREKEFNDLLVTLQDLVSGFSDDRKPLFRAVDAMGDLTATTADLVRDGRAPLKEDIHQVGRVAERLADNVPLVEEFLEQTPVKMATLGRLASYGSWFNLYLCEARVTGVSMSDGSEPPTGITVHPPRCER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N326</accession>
    <name>A0A0F7N326_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protoheme IX farnesyltransferase</fullName>
            <ecNumber evidence="8">2.5.1.141</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Heme B farnesyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Heme O synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ctaB</name>
        <name evidence="9" type="ORF">AA958_05620</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>(2E,6E)-farnesyl diphosphate + H2O + heme b = diphosphate + Fe(II)-heme o</text>
            <dbReference type="Rhea" id="RHEA:28070"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="ChEBI" id="CHEBI:60530"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.141"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Porphyrin-containing compound metabolism; heme O biosynthesis; heme O from protoheme: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="8">Carbon 2 of the heme B porphyrin ring is defined according to the Fischer nomenclature.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.141" evidence="8"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015117.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_05620"/>
    <dbReference type="EnsemblBacteria" id="AKH81763">
        <property type="protein sequence ID" value="AKH81763"/>
        <property type="gene ID" value="AA958_05620"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_05620"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1177"/>
    <dbReference type="OrthoDB" id="1875497at2"/>
    <dbReference type="UniPathway" id="UPA00834">
        <property type="reaction ID" value="UER00712"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008495">
        <property type="term" value="F:protoheme IX farnesyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048034">
        <property type="term" value="P:heme O biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13957">
        <property type="entry name" value="PT_UbiA_Cox10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00154">
        <property type="entry name" value="CyoE_CtaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006369">
        <property type="entry name" value="Protohaem_IX_farnesylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030470">
        <property type="entry name" value="UbiA_prenylTrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43448">
        <property type="entry name" value="PTHR43448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01473">
        <property type="entry name" value="cyoE_ctaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00943">
        <property type="entry name" value="UBIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="36"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="58"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="252"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH81763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="313" mass="34240" checksum="E846E7CBA361877F" modified="2015-07-22" version="1">MTAVESRPAGVLGQGTAHRPTGARVKAFVALTKPRIIELLLITTVPVMFLAAEGVPDLWLVLATCIGGYLSAGGANALNMYLDRDIDALMHRTEQRPLVTGMVRPAEGLAFGLALTVVSTVWFATLVNPLSAALALGANLFYVLVYTMLLKRRTSQNIVWGGIAGCMPVAIGWSAVTNSVSWASLILFLVMFFWTPPHYWPLSMKVKDDYARVKVPMLPVVASNKVVARQIVAYSWVMVAVSLLLWPLGYTGWFYPVVAAVLGAVWLREAHGLLRRAKSGVVGAKLKEMRLFHWSITYVSLLFIAVAVDPFLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-12-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3B4</accession>
    <name>A0A0F7N3B4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AA958_10115</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015863.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH82521">
        <property type="protein sequence ID" value="AKH82521"/>
        <property type="gene ID" value="AA958_10115"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_10115"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2130"/>
    <dbReference type="OrthoDB" id="149255at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004869">
        <property type="entry name" value="MMPL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03176">
        <property type="entry name" value="MMPL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="187"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="234"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="312"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="376"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="537"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="563"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="605"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="646"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="682"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="domain" description="MMPL" evidence="8">
        <location>
            <begin position="61"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="MMPL" evidence="8">
        <location>
            <begin position="408"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="341"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH82521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="744" mass="78800" checksum="29C940456F257A06" modified="2015-07-22" version="1">MRNLPVRTARWSARHPWRAIAGWFVFVALCLGTGIAVGGNPATTEDFWVGEAGRAEQMATEGGLERKPTEHVLIRAESGRSLDHAAARAAARDITDRMERLPEVASVAAPVRSAHGEALRVPVVLKGAELDGKKNVGPLLEQTGKAAAAHPGVVIEETGSPAISKGVNEQRGEDLALSERISLPVTLVTLLVVFGSFVMAGVPLLLALTSIAAALGLSMTASHLLPDPGVGTNLILLIGLAVGVDYTLFYLKREREERARAEGRLSSAALVELAASTAGRAIVVSGLAVIVSTATLYLATDVIFSSLATGTILVVAMAVVSSLTALPALLVTIGRRTERRAARREARGATPRRRRQRPEHGRVFAALMRPAQRRPAATLVVSVLAMAALAVPALDMKLVDPGKDTFSRDIPAMQTYDRLTAAFPELKVEHEVVARAAAERAPEVRRALAGLGRRVSADPLFVRDAEPAVRTSPDGRTSVLVLSVPHFANSRPAKDSLRHLRDEHLPATVGRLAGVETAVSGDVARGTDYVEDERDKLPLVVGALLLLTFVMTVIAFRSVVIGLLGVVLNLLSAAAALGALVIVFQGTWAEGLLDFDSMGAIASRVPLFLFVILFGLSMDYQVFVVSRIKEARDTGMPARESVIAGIGASAKVVTSAAVVMVTVFAGFVALHLTEMKQMGFCLALAVLLDAVVIRLMVLPAALLLLGERAWWRTPRRPAPLPAAGVPVPVGGADGETARTARNVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3U0</accession>
    <name>A0A0F7N3U0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">YCII domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_11120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the YciI family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016029.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_11120"/>
    <dbReference type="EnsemblBacteria" id="AKH82691">
        <property type="protein sequence ID" value="AKH82691"/>
        <property type="gene ID" value="AA958_11120"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_11120"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2342"/>
    <dbReference type="OrthoDB" id="1780176at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005545">
        <property type="entry name" value="YCII"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03795">
        <property type="entry name" value="YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YCII" evidence="2">
        <location>
            <begin position="12"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH82691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="86" mass="9611" checksum="19853739860E7F83" modified="2015-07-22" version="1">MLVLELSFSPTPDRLAARTAHRERLARLHRDKVLLAAGPWADDSGALLVFDTTRDRLDALMADDPYYRTPGVRVVGVREWSPVVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3U9</accession>
    <name>A0A0F7N3U9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">3-methyl-2-oxobutanoate hydroxymethyltransferase</fullName>
            <ecNumber evidence="5">2.1.2.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Ketopantoate hydroxymethyltransferase</fullName>
            <shortName evidence="5">KPHMT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">panB</name>
        <name evidence="10" type="ORF">AA958_07225</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + 3-methyl-2-oxobutanoate + H2O = (6S)-5,6,7,8-tetrahydrofolate + 2-dehydropantoate</text>
            <dbReference type="Rhea" id="RHEA:11824"/>
            <dbReference type="ChEBI" id="CHEBI:11561"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="5 8">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantoate from 3-methyl-2-oxobutanoate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 5">Homodecamer; pentamer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the PanB family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.11" evidence="5"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015399.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_07225"/>
    <dbReference type="EnsemblBacteria" id="AKH82049">
        <property type="protein sequence ID" value="AKH82049"/>
        <property type="gene ID" value="AA958_07225"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_07225"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1514"/>
    <dbReference type="OrthoDB" id="916845at2"/>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00003"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003864">
        <property type="term" value="F:3-methyl-2-oxobutanoate hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06557">
        <property type="entry name" value="KPHMT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00156">
        <property type="entry name" value="PanB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003700">
        <property type="entry name" value="Pantoate_hydroxy_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20881">
        <property type="entry name" value="PTHR20881"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02548">
        <property type="entry name" value="Pantoate_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000388">
        <property type="entry name" value="Pantoate_hydroxy_MeTrfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00222">
        <property type="entry name" value="panB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3 5" id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 10" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Alpha-ketoisovalerate binding" evidence="5 7">
        <location>
            <begin position="73"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5 6">
        <location>
            <position position="210"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7 8">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>3-methyl-2-oxobutanoate</name>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000388-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000388-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000388-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AKH82049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="293" mass="30899" checksum="6D5679DAB4D38976" modified="2015-07-22" version="1">MTHVSHARKTPGGADSAPALYGGDGGNRGRRVTIRDLAAAKRRGEKWPMLTAYDSTTAGIFDEAGIPVLLVGDSMGNVHLGYDTTVPVTLDEMTMLSAAVVRGTRRALVVGDLPFGSYQEGPVQALRSATRLVKDAGVGAVKLEGGERSLRQTELLVESGIPVMSHLGLTPQSVNAMGYRVQGRSDEDAHRLVRDAKAAQEAGAFAVVLELVPAEVAAEVTRSLEIPTIGIGAGIDTDAQVLVWTDMAGLTGGKLPRFVKQYAQLRQSLGDAARAFAEDVGSAAFPAEEHTFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N411</accession>
    <name>A0A0F7N411_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">N5-carboxyaminoimidazole ribonucleotide mutase</fullName>
            <shortName evidence="3 4">N5-CAIR mutase</shortName>
            <ecNumber evidence="3 4">5.4.99.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">5-(carboxyamino)imidazole ribonucleotide mutase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">purE</name>
        <name evidence="7" type="ORF">AA958_11485</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + H(+) = 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate</text>
            <dbReference type="Rhea" id="RHEA:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58730"/>
            <dbReference type="ChEBI" id="CHEBI:77657"/>
            <dbReference type="EC" id="5.4.99.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route): step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the AIR carboxylase family. Class I subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.18" evidence="3 4"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016087.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_11485"/>
    <dbReference type="EnsemblBacteria" id="AKH82751">
        <property type="protein sequence ID" value="AKH82751"/>
        <property type="gene ID" value="AA958_11485"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_11485"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2417"/>
    <dbReference type="OrthoDB" id="1701464at2"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00943"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034023">
        <property type="term" value="F:5-(carboxyamino)imidazole ribonucleotide mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01929">
        <property type="entry name" value="PurE_classI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033747">
        <property type="entry name" value="PurE_ClassI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000031">
        <property type="entry name" value="PurE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024694">
        <property type="entry name" value="PurE_prokaryotes"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00731">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001338">
        <property type="entry name" value="AIR_carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01001">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01162">
        <property type="entry name" value="purE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="1 3 4" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIRC" evidence="6">
        <location>
            <begin position="7"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR001338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001338-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH82751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="171" mass="18052" checksum="1D3704AA8E3A4174" modified="2015-07-22" version="1">MSAENGPLVGIVMGSDSDWPVMEAAAQALDEFEVPYEVDVVSAHRMPREMIAYGEEAASRGLRTLIAGAGGAAHLPGMLASVTPLPVIGVPVPLKYLDGMDSLLSIVQMPAGVPVAAVSVAGARNAGLLAARILAAHDEDLRARMTAFQEDLNHQAREKGTRLRRKTTRAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4Q9</accession>
    <name>A0A0F7N4Q9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_09040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015696.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_09040"/>
    <dbReference type="EnsemblBacteria" id="AKH82349">
        <property type="protein sequence ID" value="AKH82349"/>
        <property type="gene ID" value="AA958_09040"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_09040"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1905"/>
    <dbReference type="OrthoDB" id="70058at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032856">
        <property type="entry name" value="GDE_N_bis"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14742">
        <property type="entry name" value="GDE_N_bis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GDE_N_bis" evidence="2">
        <location>
            <begin position="11"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="656"/>
            <end position="676"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH82349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="704" mass="73489" checksum="EE417FF7B91BB795" modified="2015-07-22" version="1">MSGVEHRLLFHGGAFAAVTRAGDITGARGTQPDGFFLGDTRHLSRWQLTVDGAVPTLLVAEPAAAVLVPPTGRDEPPPHTVFREQRVEGGALVDVLRVTSNRAEPEKLWLALTVDADFADQFELRADHRVYGKSHAVRGREVLPAGVEFHYRRGGWQASTTVTAEPPPDAVEETGSGARRLVWHLKLDPHETTELTLRAAARPGAGPLPTAGPGAVTEDPAVDAAARRAATDAGARATGTEAAEAAVGAAPRPAAVAASRPEAAPGAADVPPGTAGTARTAATPVPTSHHPAPWPGLAQAAEQGLADLDGLLIPAAGPGGEQVRVPAAGVPWYLALVGRHALVTSLFALRHRPALARATLLALAATQAEEADGEPGKIVHEVRHGELAHFGQVPYGRYYGAVDTTPLFLVLLGALTGHTGDDKPARRLEPQARAAVEWMFRDGGLGDSGYLRHRADDGRAGTGPANQSWRDSPGALCAADGTRVTGALAPAAPQGYAYAALVHTARLASTAWADRRLADRLTAAADDLRARFLTDFWLSAQDFPALALDGAGRPADALASDAGHLLWSGLLDPERARRVGRRLLEPDFFSGWGVRTIAAGQGAYHPMAYHRGSVWPHDNAILTLGLARYGLHEEARTVARALTDLAAHSAGRLPEATAGYPRASQPTPVPFPHAASPQSWSAAAPLALLTALTTAGNPSGGLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4S6</accession>
    <name>A0A0F7N4S6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_13050</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016334.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_13050"/>
    <dbReference type="EnsemblBacteria" id="AKH83001">
        <property type="protein sequence ID" value="AKH83001"/>
        <property type="gene ID" value="AA958_13050"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_13050"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2746"/>
    <dbReference type="OrthoDB" id="947123at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519187" evidence="3">
        <location>
            <begin position="40"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="471"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="641"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="644"/>
            <end position="658"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH83001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="696" mass="72267" checksum="B1D3B416C8E783F7" modified="2015-07-22" version="1">MVKSVGGAGASVRAMLTAGLLLLLASLTAAGVPAGDAVAAGRAEGDGGRSGGGGGQAAYLAEQLRAEPVYVTDQAPREIPRSAAGEFAKAAKRTGVPTYVVLLPERNPFDERLLGAVHDRLRRDGLYVLLDSSGIGITAVPFGVDVPAESAATVALYELPYDAGPLLTFQRFVEALTDDDPAGRAEAAREKYGSDAGRAPEEEPERLHITRTDRANQSFLTGILLAGVPLLALLLVPYVLRRRAARAGAKTTGRGFADVGGRGLPAAVATAAVLAGSIALGAAVLYDEETTDPGPPPTRADMDARLDRVSAGLAQDPVYVDPESPAQIDSAELAGLRRKIGGLDVPVYVASVPMAPEDESGGQADTFLKALGRTAGGDGVYVLADPRSGYVSAVDHGIGLDVDLYLLPEAIGYPPRDVDDDDLRLGERVAMLVEELDGARPGGAPGRAPSPMDPPDPVAEDALPSVFAADFAPGLFVGTLAAGLVFGLVAGTVRIFRRVRPARTAAVAAAGERSYEAPPDPSEAYLRRTAHAELEALAREFETADPAGALRVRVWDCLDAAQLLVDVEEDGRIDTDATAESLATAITLIRAARATLAAPGTPARLCTLNPMHGPAHGRQRIRPAPGAPARTVPLCAGCRRAARSDPGTAHRRRLTLPSPRGEARIPYDTAPGPLRTAGEGVPRLIREVQEAAGVHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5K8</accession>
    <name>A0A0F7N5K8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_11080</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016021.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_11080"/>
    <dbReference type="EnsemblBacteria" id="AKH82683">
        <property type="protein sequence ID" value="AKH82683"/>
        <property type="gene ID" value="AA958_11080"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_11080"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2333"/>
    <dbReference type="OrthoDB" id="1510342at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="251"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="303"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="378"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="438"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="475"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="507"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="556"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="613"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="106"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="439"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH82683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="646" mass="70080" checksum="6E7B692550076F17" modified="2015-07-22" version="1">MTTTPRTEAAADPVRNEGGAPPTSPGPRAGAAPPPVSPLRALWRRTVPARWLAPGTLLIAAVIVFPAIYMVGMSFVEINRIGLTDGFAGLENYRSLFAEDELPGVVGNTLLWVVVVVGLTVLASLALAQFLAKDFVGRRFVRLALIVPWATSLVMTATVWRFLYEGGNGLLNRLLMDLRILDSPVDWYKDPDIAFFSLMAVGVITSIPFTAYVLLSGLQTIPGEVWEAAKIDGAGPWTTWRRVTLPMLRPSLTVALVLNMLHVFNAFALIWVIMGKTAGNHADTSVTFMYKIAFTGRLDTGEAAALGVLNVIAISLLIAVLIRLLKGRAPAAYGKERAGSGAAEALGRRTRLASAALARALRPVTGPLAAGWRRVRHIGLPLAGLGVALFFLAPYVAMFLGSLKTDAELFQVPADYLPDEWAWSNYADVWDKIPLADYFRVSLIVALVSTAVVLLIAAPAAFILARTDFRGRGAFLGLVLVSQMFPAVALLIGLYREAVFTGGIHSYWFIIAVNCAFNIAFAIWILHTQFSSIPVEIDEAAMLDGLGRFRTLVRMALPLAAPALITVTIFTFIQVWNEFVISLTVFNEPTENRVPLTVGVQQFVGLYETNYQYLFAASLMAIVPAVILFALIERFLVSGLTKGSTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-10-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5Q5</accession>
    <name>A0A0F7N5Q5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_11390</name>
    </gene>
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        <lineage>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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</entry>
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            <authorList>
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">CNQ-509</strain>
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            <dbReference type="EMBL" id="AKH82813.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="84" mass="9275" checksum="757F158FE0198615" modified="2015-07-22" version="1">MVSHMKTTVDISDALLTEARRTARRNGTTLKALIEQGLRAVLEEEADRAAFTLRDASVTGDGLQRDVRGASWDEIRDLAYGDRA</sequence>
</entry>
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    <accession>A0A0F7N610</accession>
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        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
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                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
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            <begin position="1"/>
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    <evidence type="ECO:0000256" key="1">
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    </evidence>
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            <dbReference type="EMBL" id="AKH82848.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="127" mass="13921" checksum="3A62D4B7FAFA315C" modified="2015-07-22" version="1">MSDTHERPDDPDGRGHRVPDTGELAQQIEELERKSATASRLFDVRRLIGGLFVAYGLILAITGAFDSDAEIAKAEDVRINLWTGLGMLALGLFFLVWHLLRPVRPPSGEELAEAIDGDGGQDRPDAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N646</accession>
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                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="532" mass="58624" checksum="E2913D3535DC64A0" modified="2015-07-22" version="1">MGRERQFKGTDAEIALARFLCDITESLGLDTVKKAAGHFPHIGSRSTWAEYLNGAKRIPQPVLRDVLQELRRMRPDKWSGRLLVEANALWKAAAEGTPPPQDSSSSELVSLYRRLTETTEALYKAQSVAMNSESVIRLLLQFAGWQERRVADLAHEVEQLRERERAQAARSLDRARFRLSRVQAELERARSDRYTAEQAQTTLMREQQEIYRDFEQLQQAASDPDIEPTLLPERAPEPQMSDEEIDRRMDEQLDLIGTDREQRGVMLSEVLEQSGLDPETEEDGPRILRGTVVTEHTPAQGPAPLPARSEAVQELSRTMSDGPPTGNETFAHGPSAPSGQWRTRRKLAFGGLAIALVGAAVLVAYAVQGGDAAGPGGGDATSAAQRCLARPGSWKLKQMTEEPHDAHSVNISFTGSSVFTFHADGTGTRVDQALKTTTSYEEIEENTAPWAPIHGKQNGTIAFRYGIKEDETGLMVTFIQKKGKITQYTNGDGVDPSRSNLKLSDGFFSCADDVLTISWGGVGGRSDTYTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N671</accession>
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    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
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            <name>pyridoxal 5'-phosphate</name>
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        </cofactor>
    </comment>
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    <dbReference type="EnsemblBacteria" id="AKH82883">
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    </dbReference>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR003739">
        <property type="entry name" value="Lys_aminomutase/Glu_NH3_mut"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
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        <location>
            <begin position="66"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="6">
        <location>
            <position position="295"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR603739-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH82883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="329" mass="37794" checksum="243F7DE8D67D0ADA" modified="2015-07-22" version="1">MTTQGEFMDEARFAEKTTSHLRQLAETSDAIKTMYFFDPETEDIPADTNRDLLNEKVNTPIFGTVRKFDGRLLVLLSYTCAANCRYCERQDRVGVGLDRVGRLGTPQIDRIVKYIAQDPTLYEIIASGGDPLVNPKGLEYLFESLQAVEHVKVLRIHTRFPLQTPRQVNMDLMRRLAVMKPTVYLSLHIDHPDELTPETVELIREFRSAGFILISQSVFLKGVNDSADTLADMFTRLFQLGVRPYYIYHCQRILTTERFEMELADEIAIMSELRERLSGLAFPQHVLDLPSARGKVLVPSNHWRFDPTFTRDFDGTELSTISWSPREPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6A6</accession>
    <name>A0A0F7N6A6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ATP-grasp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_12290</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016219.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_12290"/>
    <dbReference type="EnsemblBacteria" id="AKH82884">
        <property type="protein sequence ID" value="AKH82884"/>
        <property type="gene ID" value="AA958_12290"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_12290"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2584"/>
    <dbReference type="OrthoDB" id="764798at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008716">
        <property type="term" value="F:D-alanine-D-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011095">
        <property type="entry name" value="Dala_Dala_lig_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07478">
        <property type="entry name" value="Dala_Dala_lig_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="2">
        <location>
            <begin position="111"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH82884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="337" mass="36416" checksum="11FAB4B2F4FD6B0F" modified="2015-07-22" version="1">MVVLLHHVPDPEVRTWGDLTPQVLANFETVDSIAAMVDHIRPYIPGLTAVNVADDDWRLRTFGHRVFNYTYAFGMLADSALPTVALEGAGADYFGARPQGLYCSANKPYCSDLMAALGFRCPKQRIVAGRMDAAQAEKVSREFAGSEQLVVKPACEDSSVGLSLINNAPTEIRTAVNGLHEMLQGVVLLQDYVEGQDVTVPVIGRSQARCLPALTLSHETPLSGPFVFDAQAKATKEKVHYEPVADWPRALREHLYAMATTAFGAVGLRDYARLDCRVTPAGECLFLEVNANPQLGLSKASFAVSAQAAGMTLGKVVQMIVDDEPLPFGDSPLQVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6E9</accession>
    <name>A0A0F7N6E9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">3'-kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_20680</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the aminoglycoside phosphotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017491.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH84205">
        <property type="protein sequence ID" value="AKH84205"/>
        <property type="gene ID" value="AA958_20680"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_20680"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4362"/>
    <dbReference type="OrthoDB" id="1457558at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05150">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024165">
        <property type="entry name" value="Kan/Strep_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000706">
        <property type="entry name" value="Kanamycin_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APH" evidence="6">
        <location>
            <begin position="11"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000706-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000706-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH84205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="262" mass="28207" checksum="083C0E39F02DF29C" modified="2015-07-22" version="1">MTPLLPDDTEWTPVTTGESGAAVFRSTDGTRYARCVPAEVAAELTGERDRIAWLATQGVPGPRVLDFRSDDVGACLVTGAVPGVPADQLSAADLRACWKRIADAVRALHEVPIAECPFHRDLDLMISVARTVVAVGTVNPAFLPVEQQTTPAPQLLARLEPQLARRRAQEAADTVVCHGDLTLPNIILDPATLDVAGFVDLGRLGLADRHADLALLLANSRETWPDEAEARAQDAAFAGHYGTAPDPDRLRFYLHLDPLTWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6J7</accession>
    <name>A0A0F7N6J7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L7/L12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rplL</name>
        <name evidence="7" type="ORF">AA958_21050</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL12 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017548.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_21050"/>
    <dbReference type="EnsemblBacteria" id="AKH84265">
        <property type="protein sequence ID" value="AKH84265"/>
        <property type="gene ID" value="AA958_21050"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_21050"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4433"/>
    <dbReference type="OrthoDB" id="1822695at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00387">
        <property type="entry name" value="Ribosomal_L7_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00368">
        <property type="entry name" value="Ribosomal_L7_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000206">
        <property type="entry name" value="Ribosomal_L7/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014719">
        <property type="entry name" value="Ribosomal_L7/12_C/ClpS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013823">
        <property type="entry name" value="Ribosomal_L7/L12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008932">
        <property type="entry name" value="Ribosomal_L7/L12_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036235">
        <property type="entry name" value="Ribosomal_L7/L12_oligo_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45987">
        <property type="entry name" value="PTHR45987"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00542">
        <property type="entry name" value="Ribosomal_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16320">
        <property type="entry name" value="Ribosomal_L12_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48300">
        <property type="entry name" value="SSF48300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54736">
        <property type="entry name" value="SSF54736"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00855">
        <property type="entry name" value="L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_L12_N" evidence="6">
        <location>
            <begin position="6"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L12" evidence="5">
        <location>
            <begin position="62"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH84265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="128" mass="13480" checksum="71F3707A1C2119FD" modified="2015-07-22" version="1">MAKLSQEDLLAQFEEMTLLELSDFVKKFEEKFDVEAAAPAAVVAAPGGGAAAAEAAPEQDEFDVVLLGAGEKKIQVIKVVRELTSLGLKEAKELVDGTPKPVLEKVNKEAADKAKESLEGAGASVEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6Q4</accession>
    <name>A0A0F7N6Q4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_13195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AKH83029">
        <property type="protein sequence ID" value="AKH83029"/>
        <property type="gene ID" value="AA958_13195"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_13195"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2777"/>
    <dbReference type="OrthoDB" id="1351747at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
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    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
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    </dbReference>
    <dbReference type="Pfam" id="PF00248">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="15"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="327" mass="35471" checksum="67BA330BF15FE66E" modified="2015-07-22" version="1">MRYTQLGRTGLKVSRLVLGTMNFGPHADEAASHAMMDAALDAGVNFFDTANVYGWGENKGRTEEIVGTWLAQGGSRRDKVVLATKVYGSMAADSDTTWPNHDRLSALNIRRAVDASLKRLQTDHIDLYQFHHVDRHTPWDEIWQAVDVLVQQGKILYVGSSNHAGWHIAQANEAARRRHSLGLVSEQCLYNLYERRAEMEVIPAAESYGLGIIPWSPLGGGLLGGALRKEREGGGARSSAALARGAVRERVQAYEDLVAEHGLDPAEVALAWLLTRPGVTGPIVGPRTIGQLTSALPALDLTLPDGLLASLDEIFPGPGPSPEAFAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N744</accession>
    <name>A0A0F7N744_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">T2SSF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_14350</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP011492">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AKH83218">
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        <property type="gene ID" value="AA958_14350"/>
    </dbReference>
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    <dbReference type="PATRIC" id="fig|444103.5.peg.3020"/>
    <dbReference type="OrthoDB" id="2079512at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="244"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="7">
        <location>
            <begin position="135"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH83218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="273" mass="27569" checksum="AEA7FDCC52E35EB1" modified="2015-07-22" version="1">MRMRAEFIHSLWTVFSVLAAAYCAADAALASWRARVGRRRLPAVLGPVAPPVRPEPAGAPGGGREPAMVRLRAAAVRWGPGLLAGAAVLIFVGGAVGAVAGLAAAYGIRRWQRRTATVARRDAGIRTGPDLALAADLLAACLAAGAGPREAAAEVGRSLGGPVGTRLAQGAAELRLGAAPHAAWAPLAELPGAARLAGWLEQADHTGVPVVDAVSRLAAECRAEETRAAAARARRAGVKVAGPLGLCFLPAFLAVGVAPVVMGLAAQLLGGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N777</accession>
    <name>A0A0F7N777_9ACTN</name>
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        <submittedName>
            <fullName evidence="3">Aldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_22135</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84445.1"/>
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_22135"/>
    <dbReference type="EnsemblBacteria" id="AKH84445">
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        <property type="gene ID" value="AA958_22135"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_22135"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4662"/>
    <dbReference type="OrthoDB" id="1452155at2"/>
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    </dbReference>
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        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
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    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
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        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="2">
        <location>
            <begin position="26"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH84445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="298" mass="31253" checksum="C36C4DD0DC81D578" modified="2015-07-22" version="1">MTQADARLSVLKTYKLYVGGKFPRSESGRVYEVTDAKGRWLANAPRASRKDARDAVVAARKAVAGWSGATAYNRGQVLYRVAEMLQGRREQYVAEVADAEGLSKPKSAAQVDAAIDRWVWYAGWTDKIAQVAGGGNPVAGPYFNLSAPEPTGVVAVVAPQESALLGLVSVLAPVIATGNAAVVVAAEERPLPALSLAEVLATSDVPGGVVNVLSGRTAEIAPTLAAHQDVNAIDLAGADAELARELEVAAADNLKRVLRPRPPYDWTADPGTGRLTAFLETKTVWHPTGSLGVSGSAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7A0</accession>
    <name>A0A0F7N7A0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_19000</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the N(4)/N(6)-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017231.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="REBASE" id="113745">
        <property type="entry name" value="M.Ssp509ORF19000P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH83936">
        <property type="protein sequence ID" value="AKH83936"/>
        <property type="gene ID" value="AA958_19000"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_19000"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3989"/>
    <dbReference type="OrthoDB" id="1487464at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006306">
        <property type="term" value="P:DNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002941">
        <property type="entry name" value="DNA_methylase_N4/N6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001091">
        <property type="entry name" value="RM_Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01555">
        <property type="entry name" value="N6_N4_Mtase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00508">
        <property type="entry name" value="S21N4MTFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N6_N4_Mtase" evidence="6">
        <location>
            <begin position="22"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="N6_N4_Mtase" evidence="6">
        <location>
            <begin position="169"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH83936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="251" mass="27332" checksum="17C5BEF42CCEACC2" modified="2015-07-22" version="1">MPFSLHQGDALTVLSGLPDDCVDSVITDPPYNSGGRTAKERTTRSAKQKYTSADAKNTLADFTGENMDQRSYGFWLTQIMTEAHRLTRTGGTGLLFTDWRQLPITTDAIQAAGWLWRGVLAWHKPRARPQKGRFTQNVEFIVWASKGAIDGSRNPVYLDGMYSGSQPSGAGRRHITQKPVSVMRELVKISPPGGTVLDFCAGSGSTGVAALLEGRDFIGVEKSPHYASIASGRLTETLRETLTQDDVVLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7C8</accession>
    <name>A0A0F7N7C8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_14870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016604.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_14870"/>
    <dbReference type="EnsemblBacteria" id="AKH83289">
        <property type="protein sequence ID" value="AKH83289"/>
        <property type="gene ID" value="AA958_14870"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_14870"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3134"/>
    <dbReference type="OrthoDB" id="1950459at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH83289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="73" mass="7856" checksum="CC6CC8F2F774166D" modified="2015-07-22" version="1">MKKASAPRRHLPTSPFDAPVVPAVKTFAPGDKVTHDRYGLGTIVAAENGVAMLVDFGSCQVRVTAPYDQMEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7E6</accession>
    <name>A0A0F7N7E6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_19060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017241.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_19060"/>
    <dbReference type="EnsemblBacteria" id="AKH83946">
        <property type="protein sequence ID" value="AKH83946"/>
        <property type="gene ID" value="AA958_19060"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_19060"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4001"/>
    <dbReference type="OrthoDB" id="1161781at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005523">
        <property type="entry name" value="DUF317"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03771">
        <property type="entry name" value="SPDY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SPDY" evidence="2">
        <location>
            <begin position="51"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="SPDY" evidence="2">
        <location>
            <begin position="154"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH83946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="284" mass="31145" checksum="3F3FB8C6D78011B8" modified="2015-07-22" version="1">MNDPDIDGDVYVTPRYLAGTTGIGDPALAPLLALGWELRHDDLGNAYTAAPDRRVRLGYLPEGDDDGLWRINAYRDPFGPPAWAVCFNDATPTEFVTAFTTALAIAYEAGRAAYLARPLPGIAERDPIRIIDPLLQQGWTLDRPYLGLFTIDAPDRRAGLEYTGGNLDPEAEVTTRTARWQLWAGRSIDRPAWYATASTDTPVALLAAATRCIADPTPLPRWREDTSSYIKDMAQLTPIRPPQPPTPSPLDVRRAAARRPAALPPASVPRWSTSTRPALPGPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7N7</accession>
    <name>A0A0F7N7N7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein-L-isoaspartate O-methyltransferase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">L-isoaspartyl protein carboxyl methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Protein L-isoaspartyl methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Protein-beta-aspartate methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_15650</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016716.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_15650"/>
    <dbReference type="EnsemblBacteria" id="AKH83404">
        <property type="protein sequence ID" value="AKH83404"/>
        <property type="gene ID" value="AA958_15650"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_15650"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3297"/>
    <dbReference type="OrthoDB" id="1948290at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004719">
        <property type="term" value="F:protein-L-isoaspartate (D-aspartate) O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027573">
        <property type="entry name" value="Methyltran_FxLD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000682">
        <property type="entry name" value="PCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023809">
        <property type="entry name" value="Thiopep_bacteriocin_synth_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11579">
        <property type="entry name" value="PTHR11579"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14028">
        <property type="entry name" value="Lant_dehydr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04364">
        <property type="entry name" value="methyltran_FxLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03891">
        <property type="entry name" value="thiopep_ocin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lant_dehydr_C" evidence="6">
        <location>
            <begin position="11"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00030757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH83404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="692" mass="74461" checksum="8594C65CC7A56106" modified="2015-07-22" version="1">MITRDEPAPAWRQVNLSSDTWQAAENRAVRHHLPLLAQAEDDGAITSWWFIRKRETWRLRLRPAANRDEDTTTLLMQMAEASGLNAYADVVYEPETYRFGGKRAIEIAHRLFHADSRHVLAHLARACGGPDHRHEIGLRLATRMMQAAGQDFYEQGDIWTAVAEHRATHAMAPSASTQARVQMLITAADDSPGSPLAQTPAWPAAYENAAKALADLAGHGALTRGIRAVLTDHLLFAFNRLGISAEHQAAVAHAASRTVFHRKPGSGTVPRGSDVAIAQPTTVRPVTMDTAPAPTTDPRGLRDALVAKIDSLGTFRTGAVKNAFRTIPRHLFLPEVDLATAYAPKQVVTKRAADGTAVSSASSPNIVATMLEQLDAAPGQRVLEIGAATGINAALLAELVGESGQVVTIELDDDLAEGARTHLAEAGYEHVTVLCQDGALGAPDHAPFDRITVTAGAWDIPAAWWAQLAPGGRLVVPLRLHGSGLTRSIAFTRTEEDRMVSTNSAVCGFVPLRGAAEMGEIHVRLADDAILKIDADDEPDQAALAGVLTYPAHQQWTGIHVRHDEQAAHLDLWLATVDSGMSFGKLSIGPAARDLGLAAPARRWSGAAMYVDSTLAYLTSRPVDDDADELGIITHGPNADQLTEQIGDLLHRWSQQRPGQPLITAYPAATEDDQLGDGARITRPDTRLTIGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N803</accession>
    <name>A0A0F7N803_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ion channel protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_16480</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016844.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_16480"/>
    <dbReference type="EnsemblBacteria" id="AKH83539">
        <property type="protein sequence ID" value="AKH83539"/>
        <property type="gene ID" value="AA958_16480"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_16480"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3468"/>
    <dbReference type="OrthoDB" id="599322at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02254">
        <property type="entry name" value="TrkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51201">
        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="RCK N-terminal" evidence="3">
        <location>
            <begin position="129"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="336"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="385"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH83539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="420" mass="45407" checksum="039B69A29597EBAB" modified="2015-07-22" version="1">MKYPDQRVALPRRPRAPLRQVGGRILAALFVLALAIFVVYLGRDGYHDNAGGKVGLLDAAYYATVSLSTTGYGDIVPATPGTRLTTVLVVTPLRVLFLIILVGTTLEVLTERTRQQWRLDRWRSTLRDHTVIVGYGTKGRSALQTLRAKGLDKSQVVIIDPSSKVIEAANADGFAGVVGDATRSAVLLRAEGQRAAQFVVSPQRDDTAVLVTLTVRQLNPRAKIVTAVREEENAPLLRQSGADAVITSSSAAGRLLGLSVLSPSAGTVLEDLIVQGSGLDLIERPATKAESGLHPRETDDLVVAVKRGHRLMAYDDPDVGRLEMTDRLITISRAAGPATTPEKERVVTREGGWDLGGRRDRGYRDYEDIRDPRGARGYGAHGELGGVDRGRDRDRDRDRGRNRNGDRGPGEDGGGTDDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8B1</accession>
    <name>A0A0F7N8B1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Ribonuclease H</fullName>
            <shortName evidence="5">RNase H</shortName>
            <ecNumber evidence="4 5">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rnhA</name>
        <name evidence="8" type="ORF">AA958_17235</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="5">Binds 1 Mg(2+) ion per subunit. May bind a second metal ion at a regulatory site, or after substrate binding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 5">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the RNase H family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="4 5"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016968.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_17235"/>
    <dbReference type="EnsemblBacteria" id="AKH83664">
        <property type="protein sequence ID" value="AKH83664"/>
        <property type="gene ID" value="AA958_17235"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_17235"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3624"/>
    <dbReference type="OrthoDB" id="1953872at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09278">
        <property type="entry name" value="RNase_HI_prokaryote_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00042">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022892">
        <property type="entry name" value="RNaseHI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="7">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="141"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="10"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH83664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="219" mass="22937" checksum="EB0E6020AD13EB21" modified="2015-07-22" version="1">MADLIIAACDGAASPNPGPAAWAWVVAGPDGAVARWESGPLGTATNNIAELTALLRLLESTDPAVPLEVRMDSTYAMQAVTDWLPGWRKRGWKTAAGKPVANQELVRSIDDRLTGRDVRLVHVRAHQVGGDPYNAAADAAAAESARTQNPAGTAHGSPLPTVEDAPARVPSAAPKRRSGRTGTLKAKYPGRCRCGRPYEAGTTIAKNGTGWGHMECAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8G5</accession>
    <name>A0A0F7N8G5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphate transport regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_18045</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PhoU family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0111 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_026276740.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_18045"/>
    <dbReference type="EnsemblBacteria" id="AKH83793">
        <property type="protein sequence ID" value="AKH83793"/>
        <property type="gene ID" value="AA958_18045"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_18045"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3795"/>
    <dbReference type="OrthoDB" id="1837604at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038078">
        <property type="entry name" value="PhoU-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018445">
        <property type="entry name" value="Put_Phosphate_transp_reg"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01865">
        <property type="entry name" value="PhoU_div"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH83793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="206" mass="23272" checksum="5EDACE4A760B8960" modified="2015-07-22" version="1">MRFRLTPRETSFYDMFAASADNIVTGSKLLMELLGADSSARAEIAERMRAAEHAGDDATHAILHQLNASFITPFDREDIYRLASSLDDVMDFMEEAVDLVVLYQIEELPRGVEQQIEVLARAAELTAEAMPNLRTLNHLPEFWIEVNRLENQADQIHRKLLAHLFNGKYDAIEVLKLKQIVDVLEEAADAFEKVANTVETIAVKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8K1</accession>
    <name>A0A0F7N8K1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Chaperonin GroEL</fullName>
            <ecNumber evidence="9">5.6.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">60 kDa chaperonin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Chaperonin-60</fullName>
            <shortName evidence="9">Cpn60</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 12" type="primary">groEL</name>
        <name evidence="9" type="synonym">groL</name>
        <name evidence="12" type="ORF">AA958_21470</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 11">Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9 11">Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell surface</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Secreted</location>
            <location evidence="8">Capsule</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9 10">Belongs to the chaperonin (HSP60) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="5.6.1.7" evidence="9"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017604.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_21470"/>
    <dbReference type="EnsemblBacteria" id="AKH84341">
        <property type="protein sequence ID" value="AKH84341"/>
        <property type="gene ID" value="AA958_21470"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_21470"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4520"/>
    <dbReference type="OrthoDB" id="265347at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042603">
        <property type="term" value="C:capsule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03344">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00600">
        <property type="entry name" value="CH60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018370">
        <property type="entry name" value="Chaperonin_Cpn60_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001844">
        <property type="entry name" value="Cpn60/GroEL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00298">
        <property type="entry name" value="CHAPERONIN60"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="SSF48592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="SSF52029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="SSF54849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02348">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00296">
        <property type="entry name" value="CHAPERONINS_CPN60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="29"/>
            <end position="32"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="86"/>
            <end position="90"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="415"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="479"/>
            <end position="481"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="495"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AKH84341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="541" mass="56709" checksum="4081054AE8CD226A" modified="2015-07-22" version="1">MAKTLKFDEDARRALERGVDKLADTVKVTIGPRGRNVVIDKKFGAPTITNDGVTIAREIEVEDPYENLGVQLVKEVATKTNDIAGDGTTTATVLAQALVREGLRNVAAGASPSALKRGIDAAVAAISDELLKAASPIDSKSDIAAVAALSAQDDQVGQLIGEAMDKVGKDGVITVEESNTFGLELDFTEGMAFDKGYLSHYMVTDQDRMEAVLEDPYILINQGKISSIQDLLPLLEKVMQAGSAKPLLIVAEDVEGEALSTLVVNKIRGTFNSVAVKAPGFGDRRKAMLGDMATLTGGTVVSEEVGLKLDQVGLEVLGTARRVVITKDDTTIVDGAGKADEVAGRVAQIKAEIDATDSDWDREKLQERLAKLAGGVCVIRVGAATEVELKEKKHRLEDAISATRAAVEEGIVSGGGSALVHAAKVLEDGLGLTGDEATGVAVVRRASVEPLRWIAENAGLEGYVITSKVAELTAGQGFNAATGEYGDLVKAGVIDPVKVTRSALENAASIASLLLTTESAVVEKPEPEEDAGHSHGHGHSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8P2</accession>
    <name>A0A0F7N8P2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">50S ribosomal protein L31</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rpmE</name>
        <name evidence="8" type="ORF">AA958_24810</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Binds the 23S rRNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018142.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_24810"/>
    <dbReference type="EnsemblBacteria" id="AKH84890">
        <property type="protein sequence ID" value="AKH84890"/>
        <property type="gene ID" value="AA958_24810"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_24810"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5231"/>
    <dbReference type="OrthoDB" id="2014569at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00501">
        <property type="entry name" value="Ribosomal_L31_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034704">
        <property type="entry name" value="L28p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002150">
        <property type="entry name" value="Ribosomal_L31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027491">
        <property type="entry name" value="Ribosomal_L31_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042105">
        <property type="entry name" value="Ribosomal_L31_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33280">
        <property type="entry name" value="PTHR33280"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01197">
        <property type="entry name" value="Ribosomal_L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01249">
        <property type="entry name" value="RIBOSOMALL31"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143800">
        <property type="entry name" value="SSF143800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00105">
        <property type="entry name" value="L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01143">
        <property type="entry name" value="RIBOSOMAL_L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 7" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH84890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="73" mass="8003" checksum="4CF085DE6EA002B4" modified="2015-07-22" version="1">MKRDIHPEYVETTVSCTCGNSFTTRSTVTSGTIRADICSACHPFYTGKQKILDTGGRVARFEARFGKQAAAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-10-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N913</accession>
    <name>A0A0F7N913_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_18890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017216.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH83919">
        <property type="protein sequence ID" value="AKH83919"/>
        <property type="gene ID" value="AA958_18890"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_18890"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3965"/>
    <dbReference type="OrthoDB" id="1205921at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH83919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="227" mass="23965" checksum="DBE0858E9CAAE3FF" modified="2015-07-22" version="1">MPTVEQLLDVRRDPHSGELLARGGDLAAHSILQRTGFVAVVRVHETYHRAPTGLAKDDEDRLGTEAVARLRTAGYHIDCDDAFDTDARPAGYLPLGAGVAHLADLLREATTTAEAADVLTEVTAAHDGVLAALEDVLLAAAEFHDGLGDAADPHIAQRLRHLADHHLRAVRTDLACTRDALADHPGRSTCTEQVPAGEPERSAVCACPPPPGGVPPAPPDVAAVLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N961</accession>
    <name>A0A0F7N961_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_22840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017823.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_22840"/>
    <dbReference type="EnsemblBacteria" id="AKH84566">
        <property type="protein sequence ID" value="AKH84566"/>
        <property type="gene ID" value="AA958_22840"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_22840"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4810"/>
    <dbReference type="OrthoDB" id="1714995at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH84566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="192" mass="20925" checksum="BBD72D2ED695576D" modified="2015-07-22" version="1">MGFLDSLFGRSKPVKPDLDQLFGLPSAAITLQAAVGFTPTGAGSVCFASIEGGAFAQVQQEVRALLDADSERAGAPVEFSRDDYGYSWLLSRRTPDDLPALVGDLHAVNSALEDSGFGPQLLCSLVTFHDVEMRSLALVYLYKRGTFYPFAPLSGEKRDNPLELQVKAVVKDDLRVEEDLTRWFPLWGAPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9C5</accession>
    <name>A0A0F7N9C5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Ferredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AA958_23230</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 7">Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
        <text evidence="7">Binds 1 [3Fe-4S] cluster.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_027754067.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_23230"/>
    <dbReference type="EnsemblBacteria" id="AKH84631">
        <property type="protein sequence ID" value="AKH84631"/>
        <property type="gene ID" value="AA958_23230"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_23230"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4897"/>
    <dbReference type="OrthoDB" id="1873445at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000813">
        <property type="entry name" value="7Fe_ferredoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00354">
        <property type="entry name" value="7FE8SFRDOXIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="7" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="6 7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="8">
        <location>
            <begin position="31"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH84631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="108" mass="12203" checksum="7C5E53FF85F4F35C" modified="2015-07-22" version="1">MTYVIAEPCVDLKDKACIEECPVDCIYEGQRFLYIHPDECVDCGACEPVCPVEAIFYEDDTPEEWKDYYKVNVEFFDDLGSPGGASKLGLIERDHPIVAALPPQEHDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9J0</accession>
    <name>A0A0F7N9J0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0020 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_15410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016679.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_15410"/>
    <dbReference type="EnsemblBacteria" id="AKH83367">
        <property type="protein sequence ID" value="AKH83367"/>
        <property type="gene ID" value="AA958_15410"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_15410"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3243"/>
    <dbReference type="OrthoDB" id="1772619at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034470">
        <property type="term" value="P:ncRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001510">
        <property type="term" value="P:RNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000241">
        <property type="entry name" value="RNA_methylase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01170">
        <property type="entry name" value="UPF0020"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UPF0020" evidence="1">
        <location>
            <begin position="182"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="363" mass="39242" checksum="BD9479937E294D63" modified="2015-07-22" version="1">MRDDAHFVARCARGLEPQLAAEILQRELGSITAVGHRSVHFRAWRPYDAGVTGLRTADDVFLLAARGRDVGTRKSAVPALTELAAETDPAGLLDHRDTLAGQGTVNPQGVEVSASFLGRRSFNRYDAEDAVGNALAARLKVPYHARRTKGAPPPDYASWRLTLDGTEATLMLRITPRPLHRRPYKQATVPGTLHPPLAAAMTRLADIGRGHTVLDPCCGAGTVLIEAALAHPEAGQYRGFDIDETALRAASANKTNASLDRIRLERADAGRLPLPDGTVDRIVCNPPWGTQVEAKARLAKTPTAWWRELHRLLTPTGAAVLLLPTPTPLSPAIQADLLPTHTQRIHLSGTPTYVVKLEPGKPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9J4</accession>
    <name>A0A0F7N9J4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Iron transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_26640</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IucA/IucC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018452.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_26640"/>
    <dbReference type="EnsemblBacteria" id="AKH85215">
        <property type="protein sequence ID" value="AKH85215"/>
        <property type="gene ID" value="AA958_26640"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_26640"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5605"/>
    <dbReference type="OrthoDB" id="210513at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016881">
        <property type="term" value="F:acid-amino acid ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019290">
        <property type="term" value="P:siderophore biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007310">
        <property type="entry name" value="Aerobactin_biosyn_IucA/IucC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022770">
        <property type="entry name" value="FhuF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037455">
        <property type="entry name" value="LucA/IucC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34384">
        <property type="entry name" value="PTHR34384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06276">
        <property type="entry name" value="FhuF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04183">
        <property type="entry name" value="IucA_IucC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IucA_IucC" evidence="3">
        <location>
            <begin position="198"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="FhuF" evidence="4">
        <location>
            <begin position="470"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH85215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="648" mass="69242" checksum="FFA4DB606D6A20A4" modified="2015-07-22" version="1">MNAKPAGDELPAGSGRPPVRRRLARLIEPAVPRQYRRGAEGGGGQPEPDPLEHPDPKAAADAAGTENLLRCWVREQGVAEPENGTLRLLLPASGACLRVPVRYWSAAGWHRFGRPVLHGAPKDAQPVDAVTLASLLSREAAYASAQAAGADGSGARTVPGPAGGAADLVGRVADSVRHTAVFLTARRAGSPPATADPFLTGEQSLLLGHPLHPTPKSREGLSEAEARRYSPELRGSFPLHWLAVHDSVLACDSAWTERGKGVPARELAARLAGPGPRVPPGCTPLPVHPWQAREVRERPGVAALLDAGLLRDLGPHGDPWHPTASVRTLYRPGAPAMLKLSLGVRITNSRRENLRKELHRGTEVHRLLRAGLGKEWQASFPGGFPGAPGFDVVRDPAWLAVDTPAGEPVAGLDAVVRHQPFAAQDDALCVAALTSPVPRSPKGAMRSRLQEVVGQLADRTGQRAAAVAAEWFLRYLEVVVRPVLWLDSEAGVALEAHQQNTVLLLDADGWPAGGRYRDNQGYYFRESRRAELERRLPGLGAASDTFVPDDVTDERFTYYVGVNNVLGLVGAFGAAELVDERVLLAAFRRFLEQSATAGGRCALAERLLSGGTLRCKANLLTRVHGLDELVGPVDTQSVYVTVPNPLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9R1</accession>
    <name>A0A0F7N9R1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">NADH dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_20600</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I 24 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017475.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_20600"/>
    <dbReference type="EnsemblBacteria" id="AKH84189">
        <property type="protein sequence ID" value="AKH84189"/>
        <property type="gene ID" value="AA958_20600"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_20600"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4346"/>
    <dbReference type="OrthoDB" id="1206880at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03064">
        <property type="entry name" value="TRX_Fd_NuoE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002023">
        <property type="entry name" value="NuoE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042128">
        <property type="entry name" value="NuoE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041921">
        <property type="entry name" value="NuoE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01958">
        <property type="entry name" value="nuoE_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01099">
        <property type="entry name" value="COMPLEX1_24K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="233"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="266"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH84189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="296" mass="31560" checksum="48E32F9A1B746EC7" modified="2015-07-22" version="1">MTTAEQGQAAVSLGMPQLPAPDYPAEVRERLAADAREIIARYPDSRSALLPMLHLVQSEEGHVTRTGMQFCAEMLDLTAAEVTAVATFYTMYRRKPSGDYQVGVCTNTLCAVMGGDAIFDELKEYLGVGNQETTEDGKVTLEHIECNAACDFAPVVMVNWEFFDNQTPESAKRLVDDLRAGAEVHPTRGAKLCTFKETARILAGFPDERPGAVAESGGAGPASLIGLRMAKGEEPAARVVSQRAEPHPAHPPADALEDQPPAGHPSSHDAPQQTSASDPAHPPTASADEPTEEEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9V0</accession>
    <name>A0A0F7N9V0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_21155</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017562.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH84283">
        <property type="protein sequence ID" value="AKH84283"/>
        <property type="gene ID" value="AA958_21155"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_21155"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4456"/>
    <dbReference type="OrthoDB" id="1995337at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH84283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="64" mass="7022" checksum="5E73B5EFFAF294CE" modified="2015-07-22" version="1">MTHTIDWEDPFCGEGNACFRIGTDPEGNAHIAVAGQEEDRITDSVEALRTLIRDIKAGKADHLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NA18</accession>
    <name>A0A0F7NA18_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_27635</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018614.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_27635"/>
    <dbReference type="EnsemblBacteria" id="AKH85380">
        <property type="protein sequence ID" value="AKH85380"/>
        <property type="gene ID" value="AA958_27635"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_27635"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5823"/>
    <dbReference type="OrthoDB" id="469123at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_30" evidence="2">
        <location>
            <begin position="351"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_30" evidence="2">
        <location>
            <begin position="439"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="501"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="502"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH85380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="521" mass="55873" checksum="913A6D2E9D643F52" modified="2015-07-22" version="1">MDVARGDIGGPDGLLREVRRQASRRDEPDTREILDWLHRHTGADFALVAEDGFTVDSSTAGFPREILPSLAPLLARLSGGQLAAAATRAGEWNVHCEVLGVHESRPVLVAVARSAPSPETVALISHTGTVITLLRRATDGERTWRGFQYKARQVRFGVLSALLAGGPVLARRMTTGAVPPLLKAERLRVLLLHCSPADRDRIVRVYQDPSGYHGPDLMVHCPVFKEHVICLIAEDTVAGGGGGGGGGPGGRTGGLAEELRRVVRENPGYAMGISGPHPLGATAEAYGQAAHALAAARSTPGHVVSYQGQTLLDNVLPRRPALAWARTFLRPLDTLPQTSVDITRLLMSMPRAAVARLLDLSRNTVTAHIRRVERALGLDLADVHARAAVHLALALAGPLTAHEPDERPTPPRLEDLLHSEPAAAWARTFLLPLQPRQRRTLQAWIDANTDGQQAARRLGISRNTVRAHLRTAEAHLRRDLLTAGAGIHDVVHALHISTTAMGTRKGGDSSKSAQAGPTPRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NA21</accession>
    <name>A0A0F7NA21_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Homocysteine methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_27665</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 zinc ion per subunit.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018619.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_27665"/>
    <dbReference type="EnsemblBacteria" id="AKH85385">
        <property type="protein sequence ID" value="AKH85385"/>
        <property type="gene ID" value="AA958_27665"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_27665"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5828"/>
    <dbReference type="OrthoDB" id="1149455at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047150">
        <property type="term" value="F:betaine-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017226">
        <property type="entry name" value="Betaine-hCys_S-MeTrfase_BHMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003726">
        <property type="entry name" value="HCY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036589">
        <property type="entry name" value="HCY_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02574">
        <property type="entry name" value="S-methyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037505">
        <property type="entry name" value="Betaine_HMT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82282">
        <property type="entry name" value="SSF82282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50970">
        <property type="entry name" value="HCY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 4 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Hcy-binding" evidence="5">
        <location>
            <begin position="9"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3 4">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR037505-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH85385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="312" mass="31570" checksum="C31B4DCEB4EAF3CB" modified="2015-07-22" version="1">MRPASSFADAVGRAASCGPPLVLDGGLSNQLEAQGCDLRDALWSARVLAEEPAQIEAAHAAYVRAGADVLLTASYQATFEGFARRGAGRAEAAGLLAGSVALARRVADEAPRPVWVAASAGPYGAMLADGSEYHGRYGDGMGVAELERFHRPRLEVLAAAEPDVLALETVPGVTEATALLRAAAGLGVPVWLTYTVAGGATRAGEPLADAFALAADDEAVAAVGVNCCAPEDVAYAVETAARVTGRPVLAYPNSGETWNAETHAWRGPGSFDAQAAAGWRRAGAAAVGGCCRVGPQAIAALAAELHGSGTPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NA34</accession>
    <name>A0A0F7NA34_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Aconitate hydratase</fullName>
            <shortName evidence="10">Aconitase</shortName>
            <ecNumber evidence="10">4.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">acnA</name>
        <name evidence="14" type="ORF">AA958_27755</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = 2-methyl-cis-aconitate + H2O</text>
            <dbReference type="Rhea" id="RHEA:17941"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57429"/>
            <dbReference type="ChEBI" id="CHEBI:57872"/>
            <dbReference type="EC" id="4.2.1.99"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>citrate = D-threo-isocitrate</text>
            <dbReference type="Rhea" id="RHEA:10336"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="EC" id="4.2.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <text evidence="10">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Organic acid metabolism; propanoate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 10">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.3" evidence="10"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_27755"/>
    <dbReference type="EnsemblBacteria" id="AKH85400">
        <property type="protein sequence ID" value="AKH85400"/>
        <property type="gene ID" value="AA958_27755"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_27755"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5849"/>
    <dbReference type="OrthoDB" id="363064at2"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00718"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00946"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047456">
        <property type="term" value="F:2-methylisocitrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003994">
        <property type="term" value="F:aconitate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047780">
        <property type="term" value="F:citrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
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    <dbReference type="CDD" id="cd01580">
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
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    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
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        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
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        <property type="entry name" value="Aconitase/IRP2"/>
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        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
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        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
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    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11670">
        <property type="entry name" value="PTHR11670"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="SSF53732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01341">
        <property type="entry name" value="aconitase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 10" id="KW-0408">Iron</keyword>
    <keyword evidence="8 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="10 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase" evidence="12">
        <location>
            <begin position="64"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase_C" evidence="13">
        <location>
            <begin position="702"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="395"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004717"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00007185"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
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    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AKH85400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="904" mass="97336" checksum="1D4B8D5A27149CCB" modified="2015-07-22" version="1">MSANSFDARSTLQVGGESYEIFRLDEVPGAARLPYSLKVLLENLLRTEDGANITADHIRALGSWDSQAQPSREIQFTPARVIMQDFTGVPCVVDLATMREAVKDLGGDPARINPLAPAELVIDHSVIADKFGTPDSFQVNVELEYGRNRERYQFLRWGQTAFDEFKVVPPGTGIVHQVNIEHLARVVMVRDGKAYPDTLVGTDSHTTMVNGLGVLGWGVGGIEAEAAMLGQPVSMLIPRVVGFKLTGELPTGTTATDLVLTITEMLRKHGVVGKFVEFYGAGVGQIPLANRATIGNMSPEFGSTAAIFPIDAETITYLKLTGRDAQQLALVEEYAKAQGLWHDPAHEPEYSEYLELDLATVVPSLAGPKRPQDRIELSKAAEQFRLDVRNYVEDADEPGKESFPASDAPASSNGVPTRVIPVTAPDGTTYEIDHGAVTVAAITSCTNTSNPSVMVGAALLAKKAVEKGLTRKPWVKTTLAPGSKVVMDYYDRAGLTPYLDKLGFNLVGYGCTTCIGNSGPLPEEISKAVNEHDLAVTSVLSGNRNFEGRINPDVKMNYLASPPLVVAYALAGTMKTDITREPLGTDKEGKPVYLKDIWPSEQEVEEVVAAAIGEEMFTESYQDVFAGDEQWQALPIPTGDTFAWDPESTYVRKPPYFEGMGMDPAPVEDIAGARVLALLGDSVTTDHISPAGAIKADTPAGTYLTEHGVTRRDFNSYGSRRGNHEVMIRGTFANIRLRNQIAPGTEGGYTRDFTRADAPVSFIYDAAQNYAAAGTPLVVLAGKEYGSGSSRDWAAKGTALLGVRAVIAESYERIHRSNLIGMGVLPLQFPAGATAQSLGLTGEETFAFTGITALNDGAIPETVKVTTDTGVEFDAVVRIDTPGEADYYRNGGILQYVLRQLIGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NA95</accession>
    <name>A0A0F7NA95_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA polymerase beta</fullName>
            <ecNumber evidence="4">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">AA958_28175</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="4"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_28175"/>
    <dbReference type="EnsemblBacteria" id="AKH85470">
        <property type="protein sequence ID" value="AKH85470"/>
        <property type="gene ID" value="AA958_28175"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_28175"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5939"/>
    <dbReference type="OrthoDB" id="1615112at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00141">
        <property type="entry name" value="NT_POLXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.210.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002054">
        <property type="entry name" value="DNA-dir_DNA_pol_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010996">
        <property type="entry name" value="DNA_pol_b-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027421">
        <property type="entry name" value="DNA_pol_lamdba_lyase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037160">
        <property type="entry name" value="DNA_Pol_thumb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002008">
        <property type="entry name" value="DNA_pol_X_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029398">
        <property type="entry name" value="PolB_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022311">
        <property type="entry name" value="UCP005047_YshC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14791">
        <property type="entry name" value="DNA_pol_B_thumb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14716">
        <property type="entry name" value="HHH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005047">
        <property type="entry name" value="UCP005047_YshC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00870">
        <property type="entry name" value="DNAPOLXBETA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00483">
        <property type="entry name" value="POLXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47802">
        <property type="entry name" value="SSF47802"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0227">DNA damage</keyword>
    <keyword evidence="15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0237">DNA synthesis</keyword>
    <keyword evidence="13" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="6" id="KW-0488">Methylation</keyword>
    <keyword evidence="10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="18" id="KW-0732">Signal</keyword>
    <keyword evidence="14" id="KW-0915">Sodium</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0832">Ubl conjugation</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519303" description="DNA polymerase beta" evidence="18">
        <location>
            <begin position="21"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="domain" description="POLXc" evidence="21">
        <location>
            <begin position="30"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="HhH1" evidence="19">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="HhH1" evidence="19">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="HhH1" evidence="19">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="POLIIIAc" evidence="20">
        <location>
            <begin position="367"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00024632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00025610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="SMART" id="SM00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="AKH85470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="605" mass="65551" checksum="E7269B427EE8652A" modified="2015-07-22" version="1">MLVRRGASPARLRSRTPAASATWTEVTDVASNEEVAALLQEYADLLSITGGDAFKARAYERAARAVANHSADVAALNAKELKEIPGVGASIAGKVGEYLRTGHMAAVEEARGRIPAGVRELIAIPALGPKRALVLYEELGVSSVGELATAIGEHRLRDLKGFGPKSEEKLLHGIDLLRSATGRIPVDTALALADDIVAHLSAVTGCERCAYAGSLRRRRGTVGDLDVLAAAADSAPLMAAFTGLPLVGEVIGSGETKTSIRTTGGVQVDLRVVPPGAWGAALLYFTGSKQHNIRLREIAVRKKLKLSEYGLFHARSERRIRVTTEEDVYACLGLPWIPPPLREDRGEIEAAADGGLPEPVTEDDLRGDLHTHTDLTDGIDTLEAMAEAARERGYAYYAITDHAPELRMQRMTREKMLAQRETVAELDARYRRRSGGLRLLHGTELNIAPDGSVDWPGEFLETFDICVASVHSHFTQPKDEMTRRFLAAVENPYVHVIGHPTTRKAGKRPAVEADWDAVFAACARTGTALEVNAHPNRLDLPDELILRARGHGVKFAVNSDAHSVPDLANTRYGVGIAQRGWLTPADVINTWPLARLRRFLRAKGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NA98</accession>
    <name>A0A0F7NA98_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_17055</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_17055"/>
    <dbReference type="EnsemblBacteria" id="AKH83637">
        <property type="protein sequence ID" value="AKH83637"/>
        <property type="gene ID" value="AA958_17055"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_17055"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3586"/>
    <dbReference type="OrthoDB" id="1445710at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH83637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="121" mass="12292" checksum="85DEBDEC1694CCAA" modified="2015-07-22" version="1">MAAGSIAAMRALAAAGLDRIGWIAAGLAALDRGEDLPEPFDDEGRAFDRLFTDPSVPRTLVPAPGGGNDDALQQAMALPALPAAAGPDPLRAALEALAHAAVTWGGARQELFAQARAQLPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAA7</accession>
    <name>A0A0F7NAA7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SPFH/Band 7/PHB domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_17125</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the band 7/mec-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016951.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_17125"/>
    <dbReference type="EnsemblBacteria" id="AKH83647">
        <property type="protein sequence ID" value="AKH83647"/>
        <property type="gene ID" value="AA958_17125"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_17125"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3601"/>
    <dbReference type="OrthoDB" id="1213601at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018080">
        <property type="entry name" value="Band_7/stomatin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001972">
        <property type="entry name" value="Stomatin_HflK_HflKC_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00721">
        <property type="entry name" value="STOMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="SSF117892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01270">
        <property type="entry name" value="BAND_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="PHB" evidence="4">
        <location>
            <begin position="21"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="286"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="336"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="286"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH83647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="370" mass="40439" checksum="728EAD4530CF4B3B" modified="2015-07-22" version="1">MDPVVIPILVAVLAVIFLVSASVRVVPQARRYNIERFGRYRRTLQPGLNFVVPVADRINTKLDVREQVYSSDPRPVITEDNLVVNIDTVLYYQITDPRAAAYEVSDYLQAIDQLTVTTLRNVIGGMDLEETLTSREEINARLRTVLDDATGKWGIRVNRVEIKAIDPPHSIKEAMEKQMRAERDKRAAILHAEGERQAKILTAEGTKQSDILEAQGTQQAMILRADGEAQAVERVFQAVHRNNADPKILAYKYLETLPHLANSDNNTFWVIPGELTEAVRTVTTAFGDKSASGPPEVAQTTPTPDEKPAESVTGAPALEAGAAPTLDAVTAAVEAAKEADAAVSEAKAEAEAASSTQPPRPNRKKADTDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAH0</accession>
    <name>A0A0F7NAH0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L28</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpmB</name>
        <name evidence="5" type="ORF">AA958_25795</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL28 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018839653.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_25795"/>
    <dbReference type="EnsemblBacteria" id="AKH85066">
        <property type="protein sequence ID" value="AKH85066"/>
        <property type="gene ID" value="AA958_25795"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_25795"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5433"/>
    <dbReference type="OrthoDB" id="2062238at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00373">
        <property type="entry name" value="Ribosomal_L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034704">
        <property type="entry name" value="L28p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026569">
        <property type="entry name" value="Ribo_L28/L24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037147">
        <property type="entry name" value="Ribo_L28/L24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001383">
        <property type="entry name" value="Ribosomal_L28"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00830">
        <property type="entry name" value="Ribosomal_L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143800">
        <property type="entry name" value="SSF143800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00009">
        <property type="entry name" value="L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH85066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="61" mass="6662" checksum="8F0CBCB4A96377E0" modified="2015-07-22" version="1">MAANCDVCGKGPGFGNNISHSHRRTRRRWNPNIQRVRAVVGGTPKRLNACTSCIKAGKVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAK7</accession>
    <name>A0A0F7NAK7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glyoxalase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_28715</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_027770346.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_28715"/>
    <dbReference type="EnsemblBacteria" id="AKH85565">
        <property type="protein sequence ID" value="AKH85565"/>
        <property type="gene ID" value="AA958_28715"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_28715"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6052"/>
    <dbReference type="OrthoDB" id="1984437at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH85565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="115" mass="12407" checksum="E86C84C99F2A6981" modified="2015-07-22" version="1">MEILGTSLRICVDDLESAVDTYERLTGEQAQHFSQAGVSVAAVGCFLLMSGPPQTLDVLRRITATLAVKDVAEAYATLRSVGAEIVAGPSETPIGRNMVARHPDGSIFEYVDRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAS0</accession>
    <name>A0A0F7NAS0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_26355</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018407.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_26355"/>
    <dbReference type="EnsemblBacteria" id="AKH85166">
        <property type="protein sequence ID" value="AKH85166"/>
        <property type="gene ID" value="AA958_26355"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_26355"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5548"/>
    <dbReference type="OrthoDB" id="162819at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="595"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="3">
        <location>
            <begin position="108"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH85166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="628" mass="67969" checksum="EF2EDF5F3BC75368" modified="2015-07-22" version="1">MQPTDDNAPTPGPLRRPTPAARSGRRLRRALCAGAAALALLGAATAGPAAATSAQDDGGDDGDKTVLTAAVAQSVDSLSPFLAVTLVATSLNRLMYDSLVNYDVKTQEPIPGLAEKWEPSNAGRTWTYTIRDGVKWSDGKPLTAEDARWTFHTMMTDEAAGAANGSYVANFAEVSAPSARTLVVELKEPQATMNSMDLPIVPKHVWQDVDDLGKFNNDSDFPVVGSGPFVLTGFKTDSHVTFEPNENFWRGRPKFDEVTFKYYKETDAAVAALRKGEVSFVPDLTPAQAASLKGQPDIKVNDGQGRRFWAIATNPGARDAEGRKFGDGHPALLDPRVREALFLAVDRTAIVDKVLQGHGVEGEGYIPPRFADYHWKPSAEQKIGYDPEKAARLLDRAGYEMKDGKRVGKDGKPLNFRMLCHATDPKDKAAGKFLEEWWGELGIGLDLQCLDNVGDPWVAGEYDLAFDGWSVNPDPDFVLAIHTCAALPESEDVVGQTDNFICDKDYDRLYAEQLAAYDDPAKRAEIVREMQSVLYDTGYMNVLAYPNSVEAYRTDHIESITAMPAGNGNIWGQDGSWSWATAVPAAKASDDGGSAMGVVLGGGAAVVVVVAAGVFFTLRRRATAEDRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAT8</accession>
    <name>A0A0F7NAT8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylase</fullName>
            <shortName evidence="3">GlcNAc-Ins deacetylase</shortName>
            <ecNumber evidence="3">3.5.1.103</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">mshB</name>
        <name evidence="4" type="ORF">AA958_23180</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the deacetylation of 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside + H2O = 1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside + acetate</text>
            <dbReference type="Rhea" id="RHEA:26180"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:52442"/>
            <dbReference type="ChEBI" id="CHEBI:58886"/>
            <dbReference type="EC" id="3.5.1.103"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MshB deacetylase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.103" evidence="3"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017880.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_23180"/>
    <dbReference type="EnsemblBacteria" id="AKH84623">
        <property type="protein sequence ID" value="AKH84623"/>
        <property type="gene ID" value="AA958_23180"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_23180"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4887"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035595">
        <property type="term" value="F:N-acetylglucosaminylinositol deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010125">
        <property type="term" value="P:mycothiol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01696">
        <property type="entry name" value="MshB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003737">
        <property type="entry name" value="GlcNAc_PI_deacetylase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024078">
        <property type="entry name" value="LmbE-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017810">
        <property type="entry name" value="Mycothiol_biosynthesis_MshB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993">
        <property type="entry name" value="PTHR12993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02585">
        <property type="entry name" value="PIG-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102588">
        <property type="entry name" value="SSF102588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03445">
        <property type="entry name" value="mycothiol_MshB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH84623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="298" mass="30790" checksum="9387560AA3BC8491" modified="2015-07-22" version="1">MSRELPPRRLLLVHAHPDDETITTGATMARYAAEGALVTLVTCTLGEEGEVIPPALARLGPERDDVLGAHRAGELAAAMRALGVTDHRFLGGPGRFRDSGMQGLDRNGRPGTFWSAGVDEAAGLLVPVIREVRPQVLVTYDPQGGYGHPDHVQAHRVATRAAELAAAASYDADPAEPWAVARIYWTCVARGAAEKALAELAAAGHPFPGTATVADLPGVVDDGEVTAAVAGGAYAAAKARAMAAHETQITVAGGAFALSNGLGQPILTTEQFRLAGGADAARRDPGAVETDLFAEVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NB57</accession>
    <name>A0A0F7NB57_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_23855</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017990.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_23855"/>
    <dbReference type="EnsemblBacteria" id="AKH84738">
        <property type="protein sequence ID" value="AKH84738"/>
        <property type="gene ID" value="AA958_23855"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_23855"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5027"/>
    <dbReference type="OrthoDB" id="1708060at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
        <property type="entry name" value="SSF81923"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51903">
        <property type="entry name" value="CLP_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Clp R" evidence="3">
        <location>
            <begin position="2"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH84738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="184" mass="19161" checksum="59B3F83BD2E3E348" modified="2015-07-22" version="1">MFERFTQAARDLVRGAAERAERDGDSHVAPEHLLRQLLAGSGTAGAVALAAAGVDSEARRAGVLRGLDEARRRGGLTKSDAEALAGIGIDVAAVVDRVESAHGPGALARRRAWRRGRTRFDADAKAVLERSLRIALVRGDKAIGDEHILLALAATPGIPAEVLADHGATYAAIEAALPAVQRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NB60</accession>
    <name>A0A0F7NB60_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_18910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017219.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_18910"/>
    <dbReference type="EnsemblBacteria" id="AKH83922">
        <property type="protein sequence ID" value="AKH83922"/>
        <property type="gene ID" value="AA958_18910"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_18910"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3969"/>
    <dbReference type="OrthoDB" id="1571905at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="400"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="411"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="598" mass="62949" checksum="4DDE6988D99DE580" modified="2015-07-22" version="1">MSAHHHVQSRLDDDADLARWDDDGAPPAQPRTSPAAWLRVGAELGDRLVALSGRQDLLVTCRPGTRSGAPAAFFPTLGEVEVDAGLFAPLKPHEIHPRIVGDEDRYPAAWGVFVHEAAHAAHSDWTWTAPAGANPRVVETALLLEESRVEGAHLITRPTDRTYLRTSARTLVMPDIAHPTLKGIEHAAAVAALVLGRRDVGILDAGETRAVADLCEKVLGAALLATLTRIWTAAHQCADHDATTMLAHAKEWCDALDTSAPALPVPENLTDLLSGAVGVVMDNTAATDAADLAAQAAATNAIATRSRAQANDRAQQASRRRQAAATAQSVFNARGATVTPDGTPAPYATPVTGTRRPTAAEQSAAARLSRALRAAAYRERTEERTTSPTPPGRLSMRAALARDAQRAAGSVPTAQPFTHTRRRNSPTPPLRVGIAVDVSGSMRAACAPVASAAWIVARAAALTDPDSLTATIAYDTHLTALTRPTHRAPKRVTTFGANGSSHNLANALEALDHGLELSRPGTGRLLVIVTDAIYTPDETAQAVTRVKQLTTAGCAVLQLTLTAKSHHLPGTTLLHLPQPSSAPVAIATAATDAIRRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NB70</accession>
    <name>A0A0F7NB70_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_27400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018575.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH85341">
        <property type="protein sequence ID" value="AKH85341"/>
        <property type="gene ID" value="AA958_27400"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_27400"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5774"/>
    <dbReference type="OrthoDB" id="1570162at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="4"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH85341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="232" mass="24384" checksum="17D9F36B91C72B32" modified="2015-07-22" version="1">METRNNRDRIIEAAAALLAEGGGDAVSTRAVSAAAGVQAPAIYRIFGDKQGLLDAVASHGFADYLRSKTAGQPTDDPVADLRRGWDLHVGFGLANPAFYTLIYGDQRPGTEPSAAREASAVLAGMISRIAAAGRLRMSEDRAAFLVHSTGRGVTLTLISQPENARDMSLSVLARESVIATVTTDPPRRTQPDGGGVVGHAVALRAALPQTTSLTAPERALLTEWLDRIATAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBB0</accession>
    <name>A0A0F7NBB0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Enoyl-CoA hydratase</fullName>
            <ecNumber evidence="3">4.2.1.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_27700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.17" evidence="3"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018625.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_27700"/>
    <dbReference type="EnsemblBacteria" id="AKH85391">
        <property type="protein sequence ID" value="AKH85391"/>
        <property type="gene ID" value="AA958_27700"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_27700"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5837"/>
    <dbReference type="OrthoDB" id="1275789at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH85391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="275" mass="28731" checksum="D408BA53F6BC3E0D" modified="2015-07-22" version="1">MSPFTGSAGRTAQWEHLRVTEDDGVVTVTLDRPEKLNALTFEAYADLRDLIAELARTGGTRALVLAGAGRGFCSGGDVDEIIGATLAMDTGRLLDFNRMTGQVVRALREAPFPVVAAVHGVAAGAGAVLALAADFRVADHSARFAFLFTRVGLSGGDMGAAYLLPRVVGLGHATRLLMLGDAVRAAEAARIGLLSELADEGRADEAAQALARRLAAGPTLAYAQTKALLTAELDMPLAAAVEMDAATQALLMNSADYAEFHAAFTAKRPPAWQGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBN5</accession>
    <name>A0A0F7NBN5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Lysine--tRNA ligase</fullName>
            <ecNumber evidence="9">6.1.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Lysyl-tRNA synthetase</fullName>
            <shortName evidence="9">LysRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">lysS</name>
        <name evidence="11" type="ORF">AA958_20245</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys)</text>
            <dbReference type="Rhea" id="RHEA:20792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9696"/>
            <dbReference type="Rhea" id="RHEA-COMP:9697"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78529"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.6" evidence="9"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017416.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_20245"/>
    <dbReference type="EnsemblBacteria" id="AKH84127">
        <property type="protein sequence ID" value="AKH84127"/>
        <property type="gene ID" value="AA958_20245"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_20245"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4263"/>
    <dbReference type="OrthoDB" id="256927at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004824">
        <property type="term" value="F:lysine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006430">
        <property type="term" value="P:lysyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00177">
        <property type="entry name" value="Lys_tRNA_synth_class1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020751">
        <property type="entry name" value="aa-tRNA-synth_I_codon-bd_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008925">
        <property type="entry name" value="aa_tRNA-synth_I_cd-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002904">
        <property type="entry name" value="Lys-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042078">
        <property type="entry name" value="Lys-tRNA-ligase_SC_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37940">
        <property type="entry name" value="PTHR37940"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01921">
        <property type="entry name" value="tRNA-synt_1f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48163">
        <property type="entry name" value="SSF48163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00467">
        <property type="entry name" value="lysS_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="172"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="9">
        <location>
            <begin position="39"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="9">
        <location>
            <begin position="321"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AKH84127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="573" mass="62737" checksum="55ACB4A048E603FE" modified="2015-07-22" version="1">MGATTEAADWVSRFADEVIAEAERRAPGKPVVCASGLSPSGPIHLGNLREVMTPHLVADEIRRRGVPCEHLISWDDYDRFRKVPVGVEGVDESWAEHIGKPLTSVPPPAGSPHASWAAHFKAAMEGALAEMGVTYRGISQTEMYRAGAYREQILFAMRHRAEIDAVLAEFRTKPKQQKKQQQKPVDEAELAAAEGSGAADEDDGLTAGGAYYPYKPYCGVCGRDLTTVTAYDDETTELTYTCACGHGETVRLAEFDRGKLVWKVDWPMRWAYEGVVFEPSGVDHHSPGSSWNVGGKLVGIFGWERPIGPMYAFVGISGMAKMSSSKGGVPTPAEALEIMEPMLLRWLYARRRPNQSFKVAFDQEIQRTYDEWDALVRKVGAGTAQPGDVAAYERAAGTAGGLLPATPRPLPYRMLASVTDVTAGDDEQTLRILADVDPEHPLTSLADARPRLDKAERWITTQVPADQRTQVRKDADAELLASLGDSERELLRLLLAGLDEHWSLDGLTTLLYGVPKLRAGLPADAKPTPELKAEQRAFFALLYRLLVGRDTGPRLPTLLLAVGQERVRELLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCD5</accession>
    <name>A0A0F7NCD5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Probable DNA ligase</fullName>
            <ecNumber evidence="12">6.5.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Polydeoxyribonucleotide synthase [ATP]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">ligB</name>
        <name evidence="12" type="synonym">lig</name>
        <name evidence="16" type="ORF">AA958_32405</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="12 14">Belongs to the ATP-dependent DNA ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.1" evidence="12"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019372.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_32405"/>
    <dbReference type="EnsemblBacteria" id="AKH86145">
        <property type="protein sequence ID" value="AKH86145"/>
        <property type="gene ID" value="AA958_32405"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_32405"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6840"/>
    <dbReference type="OrthoDB" id="1073940at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00407">
        <property type="entry name" value="DNA_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022865">
        <property type="entry name" value="DNA_ligae_ATP-dep_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000977">
        <property type="entry name" value="DNA_ligase_ATP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012309">
        <property type="entry name" value="DNA_ligase_ATP-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016059">
        <property type="entry name" value="DNA_ligase_ATP-dep_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012308">
        <property type="entry name" value="DNA_ligase_ATP-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036599">
        <property type="entry name" value="DNA_ligase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04679">
        <property type="entry name" value="DNA_ligase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04675">
        <property type="entry name" value="DNA_ligase_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117018">
        <property type="entry name" value="SSF117018"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00574">
        <property type="entry name" value="dnl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00697">
        <property type="entry name" value="DNA_LIGASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 12" id="KW-0132">Cell division</keyword>
    <keyword evidence="6 12 13" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9 12 13" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="10 12 13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 12 13" id="KW-0235">DNA replication</keyword>
    <keyword evidence="1 12 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="8 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 12 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_LIGASE_A3" evidence="15">
        <location>
            <begin position="287"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="active site" description="N6-AMP-lysine intermediate" evidence="12">
        <location>
            <position position="210"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="377"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="383"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AKH86145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="511" mass="54803" checksum="C99B3BB8D8DDD48C" modified="2015-07-22" version="1">MLFADLARTSREIAATRARSEKTALLAALFREADPADAPLVVTYLAGRLPQRRTGVGWSALKDAPAAARQPRLTVREVHDAFDAIAAVSGKGAQAERRRLVHELLGAATTEEQRFLAGLIGGELRQGALDALAVEGLAAAVDADPARVRRAVMLAGSVGAVAEALLARGPEALADFKLSVGSPVQPMLAQSAKDVDEAIGRLGPCAVEEKLDGIRVQVHRDGDDVRIYTRTLDEITARLPEVVAAARELTAADAVLDGEVIALGDGGDPRPFQEVAGRVGSRVDVAGAQQTLPVYPVFFDLLAVDGRDLLTAPMRERQAELARITPEPRRVRRVEVADPEDAAQRAAAREFAAVTLARGHEGVVVKALDSEYSAGRRGAAWLKVKPVHTLDLVVLGAEWGHGRRTGTLSNLHLGARREDGSFAMLGKTFKGMTDALLAWQTERLQELAVAQKDWGVVVLPELVVEVAFDGVQRSPRYPEGVTLRFARVVRYRDDKTAAEADTVASVLAMLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCM7</accession>
    <name>A0A0F7NCM7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_26175</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018374.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH85133">
        <property type="protein sequence ID" value="AKH85133"/>
        <property type="gene ID" value="AA958_26175"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_26175"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5510"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH85133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="113" mass="11356" checksum="84F97D287819CC9A" modified="2015-07-22" version="1">MVCGIVGVTLLPTVYGIVLSVLLGPAALVLGLVARSRARREGAAAGRNAVIGIATGAVAFAVAAAVIVLTLTGVIFSGDDDEEEKPAERRDGQRVQVMAERSGTLSWPGGGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCN6</accession>
    <name>A0A0F7NCN6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA polymerase sigma factor SigA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">sigA</name>
        <name evidence="9" type="ORF">AA958_26770</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Interacts transiently with the RNA polymerase catalytic core.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the sigma-70 factor family. RpoD/SigA subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_26770"/>
    <dbReference type="EnsemblBacteria" id="AKH85239">
        <property type="protein sequence ID" value="AKH85239"/>
        <property type="gene ID" value="AA958_26770"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_26770"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5632"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00963">
        <property type="entry name" value="Sigma70_RpoD_SigA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009042">
        <property type="entry name" value="RNA_pol_sigma70_r1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012760">
        <property type="entry name" value="RNA_pol_sigma_RpoD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028630">
        <property type="entry name" value="Sigma70_RpoD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00140">
        <property type="entry name" value="Sigma70_r1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02393">
        <property type="entry name" value="RpoD_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00715">
        <property type="entry name" value="SIGMA70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00716">
        <property type="entry name" value="SIGMA70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="1 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RNA_pol_sigma70" evidence="7">
        <location>
            <begin position="299"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_sigma70" evidence="8">
        <location>
            <begin position="468"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="5">
        <location>
            <begin position="469"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="58"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Sigma-70 factor domain-2" evidence="5">
        <location>
            <begin position="275"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Sigma-70 factor domain-3" evidence="5">
        <location>
            <begin position="354"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Sigma-70 factor domain-4" evidence="5">
        <location>
            <begin position="443"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Interaction with polymerase core subunit RpoC" evidence="5">
        <location>
            <begin position="299"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="153"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH85239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="508" mass="55381" checksum="6807405FCA7DEE62" modified="2015-07-22" version="1">MALIERGKAEGQIAGDDVRRAFEVDQIPPTQWKSVLRSLNQILEEEGVTLMVSAAEAPKRTRKSVPAKTPAKRTATKAVAKQAVPAKTATKKPTATATAHAVQEAPMDDPVPAGLGDPADEPEKKAAAKKTTAKKAAAKKTAAKKAPAKKAAGKKGAAKDGESGAEGPDDGSLEKEEPPAEAEAEGFVLSDEDEDDAPAQQVAAAGATADPVKDYLKQIGKVPLLNAEQEVELAKRIEAGLFAEDKLAAADKLAPKLRRELEIIAEDGRRAKNHLLEANLRLVVSLAKRYTGRGMLFLDLIQEGNLGLIRAVEKFDYTKGYKFSTYATWWIRQAITRAMADQARTIRIPVHMVEVINKLARVQRQMLQDLGREPTPEELAKELDMTPEKVIEVQKYGREPISLHTPLGEDGDSEFGDLIEDSEAVVPADAVSFTLLQEQLHSVLDTLSEREAGVVSMRFGLTDGQPKTLDEIGKVYGVTRERIRQIESKTMSKLRHPSRSQVLRDYLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCU9</accession>
    <name>A0A0F7NCU9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CbxX/CfqX</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_33390</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CbxX/CfxQ family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019535.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_33390"/>
    <dbReference type="EnsemblBacteria" id="AKH86310">
        <property type="protein sequence ID" value="AKH86310"/>
        <property type="gene ID" value="AA958_33390"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_33390"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.7051"/>
    <dbReference type="OrthoDB" id="1115436at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041627">
        <property type="entry name" value="AAA_lid_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000641">
        <property type="entry name" value="CbxX/CfxQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17866">
        <property type="entry name" value="AAA_lid_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00819">
        <property type="entry name" value="CBXCFQXSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="12"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="4">
        <location>
            <begin position="376"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="272"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH86310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="621" mass="67751" checksum="38D918F0A35DF091" modified="2015-07-22" version="1">MDNGARGPEAPAELAWLRGVDAYTMGAYTRAEEEFRSAVRLDPQMADAWLGLHALRADTATALLEMYRHRDRFGEQRARHRRPLNSWYWLGWWVQPVLDSGRDLLLAHASHWLDGRHVAELEQALAACPPAEADPQVRFLHACRAYLVKDWEQLVRLTVPLTDDPLLGIEAGLFAGMARVRLEMYGQAVPMLSAALMRCRSEQPQRKELRYWLARAQEGSGRSAAALPLYRAVHRIDPSFMDTAARIAAIDDLDDFDGLDPVPGLASVSLGGAEQETAPGDPAPPAPDGRELVPADEVLRPPPPAGGPGVLRERASLHAGSAHQPAAADPGILAEALADLDRMVGLDPVKRQVRALSAQLNMARLRAGEGLPVQPPKRHFVFSGPSGTGKTTVARILGRVFYALGLLASDRLVEAGRADLVGEFLGQTAVKANDLIDSALGGVLFIDEAYSLAGVGYSRGDAYGDEALQVLLKRAEDNRDRLVVILAGYPKGMDRLLSSNPGLTSRFTTRVDFPSYRPLELTAIGEVLAAQNGDKWDEESVEELRSICGHVVDQGWIDELGNGRFLRTLYEKSCAYRDLRLSAYPGPPGREDLATLRLPDLMQAYGEILSGREPKAEPDAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDD0</accession>
    <name>A0A0F7NDD0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_23810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017984.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_23810"/>
    <dbReference type="EnsemblBacteria" id="AKH84732">
        <property type="protein sequence ID" value="AKH84732"/>
        <property type="gene ID" value="AA958_23810"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_23810"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5018"/>
    <dbReference type="OrthoDB" id="1351747at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="17"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="342" mass="37386" checksum="3D52B6F000B1856F" modified="2015-07-22" version="1">MQYRTLGRTGIKVSPYCLGAMMFGAQGNPDHDESVRIIHKALAAGVNFVDTADIYGHGESEEIVGKALRGRRDDVVLATKAHLPMGDDPNRQGNSRRWLVRALEDSLRRLGTDHVDLFQIHRPAPDTDIEETLSALTDLVRAGKVRAVGTSAFPASDLVEAQWTAERRGLVRFRTEQPNYSVLDRGIEREVLPVCERYGMGTLVWSPLAGGMLTGRYRKGQKPTTFRGGYGFRHLADERRLDTVERLLPLAEKAGLSLTHMALAFVISHPGVTSAIIGPRTMEQLDDLLAGAGTALGDDVLDEIDAIVPPGTEVGRLDMAYDPPAILHAGLRRRAPAERVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDD8</accession>
    <name>A0A0F7NDD8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Flavohemoprotein</fullName>
            <ecNumber evidence="6">1.14.12.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Flavohemoglobin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Hemoglobin-like protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Nitric oxide dioxygenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">AA958_27985</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>NADH + 2 nitric oxide + 2 O2 = H(+) + NAD(+) + 2 nitrate</text>
            <dbReference type="Rhea" id="RHEA:19469"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16480"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.14.12.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>NADPH + 2 nitric oxide + 2 O2 = H(+) + NADP(+) + 2 nitrate</text>
            <dbReference type="Rhea" id="RHEA:19465"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16480"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.14.12.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the globin family. Two-domain flavohemoproteins subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.14.12.17" evidence="6"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018673.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_27985"/>
    <dbReference type="EnsemblBacteria" id="AKH85439">
        <property type="protein sequence ID" value="AKH85439"/>
        <property type="gene ID" value="AA958_27985"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_27985"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5898"/>
    <dbReference type="OrthoDB" id="1834577at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008941">
        <property type="term" value="F:nitric oxide dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000971">
        <property type="entry name" value="Globin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="SSF46458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01033">
        <property type="entry name" value="GLOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-0521">NADP</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GLOBIN" evidence="15">
        <location>
            <begin position="7"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="16">
        <location>
            <begin position="96"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="317"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00014637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00033187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AKH85439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="355" mass="39386" checksum="9C7899AEFFEA20F2" modified="2015-07-22" version="1">MSEQRDRLFAALTHVVQRLDDPGLPRYLATLGRDHRKFDARPEHYAAVGESLIAALRFGLPNTWDEETEQAWLGAYKILSEAMIGGSEEADKRQAPRWWDCRVVARHAAAPGVTVLTLLPDRTLPYAAGQFVSVSTPKVPRVWRPYSIGCAPRADRTIDLHVSRVDGGLLSPVLVDRTAPDDTLRLGSPAGTAVLPKRAGQPVTFIAAGTGWAPVRALLEEMVHRWTPTTARLFLVARSPAHLYDPEAVDALRKHHSWVDVTVITPEGMERQGATAHRLEAALSAHRDWAKHRVYVSGPAQFIAEVRELVRGYGTPPEQIAHDHVPSPERASREPGHSAWFLHPSQPQWINPADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDH8</accession>
    <name>A0A0F7NDH8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_27895</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018657.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_27895"/>
    <dbReference type="EnsemblBacteria" id="AKH85423">
        <property type="protein sequence ID" value="AKH85423"/>
        <property type="gene ID" value="AA958_27895"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_27895"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5880"/>
    <dbReference type="OrthoDB" id="1063432at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002838">
        <property type="entry name" value="AIM24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036983">
        <property type="entry name" value="AIM24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016031">
        <property type="entry name" value="Trp_RNA-bd_attenuator-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01987">
        <property type="entry name" value="AIM24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51219">
        <property type="entry name" value="SSF51219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH85423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="225" mass="23687" checksum="778C6AC24A0F2E21" modified="2015-07-22" version="1">MRSDLFAKENMAEPATQVGMTLQNAKSIKYAVNGECLARQGAMIAYRGNLQFEKKGQGAGQFLKRAVTGEGLALMSVKGQGECWFALSAANCFILDFDQPNDSLTLNGRNVLCFDSTLSYDIKVVKGAGMAGGGLFNSVFTGQGRLGVVCDGTPIVIPVSPGYPVFVDTDAVVGWSTQLQTGLHRSQSFGSMIRGGSGEVMQLRLDGEGFVVVRPSETGAGAPTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDL3</accession>
    <name>A0A0F7NDL3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Dihydrodipicolinate synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_33510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019553.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_33510"/>
    <dbReference type="EnsemblBacteria" id="AKH86331">
        <property type="protein sequence ID" value="AKH86331"/>
        <property type="gene ID" value="AA958_33510"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_33510"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.7077"/>
    <dbReference type="OrthoDB" id="1438588at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="PTHR12128"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH86331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="350" mass="37172" checksum="A66FF4E376A11883" modified="2015-07-22" version="1">MPTERPTPLDVLADGAVIPAHPLALTADRHLDERRQRALTRYYLAAGAGGIAVAVHTTQFAIREPQVGLLRPVLELAAETAAESAAASGRPAVRIAGACGYTAQAVAEAELAASLGYDAVLLSPAVPGANEEGLLDRARAVGEVLPVIGFYLQEAVGGRYLSPAFWAALADQPSTAAIKIAPFDRYRTADVVRAVAGADRGPEVALYTGNDDDIAGDLLTPYDTAGGRRWFAGGLLGQWAVWTRPAAGLLADVRRARAGDHEALLRCLTRRPQLTDANSAVFDVRGGFRGCIAGVHEVLRRQGLLAGTWCLDPGEVLSPGQADELTRVAAAYPWLTDDDFVKEHLDDWLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDM7</accession>
    <name>A0A0F7NDM7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carbon monoxide dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_28265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018722.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_28265"/>
    <dbReference type="EnsemblBacteria" id="AKH85488">
        <property type="protein sequence ID" value="AKH85488"/>
        <property type="gene ID" value="AA958_28265"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_28265"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5958"/>
    <dbReference type="OrthoDB" id="1017413at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005107">
        <property type="entry name" value="CO_DH_flav_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036683">
        <property type="entry name" value="CO_DH_flav_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002346">
        <property type="entry name" value="Mopterin_DH_FAD-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03450">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00941">
        <property type="entry name" value="FAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01092">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55447">
        <property type="entry name" value="SSF55447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="299" mass="31510" checksum="702BCB6BF1EEE8B9" modified="2015-07-22" version="1">MDFLRPASWAEALAAKAEHPEAVPIAGGTDLMVEINFDHRRPEYLLDLNRIGELGEWETGAESVRLGASVPYARIVAELGGALPGLARAAHTVASPQIRNRGGVGGNLGTASPAGDAHPALLAAGAEVEVESVRGGRRIPVDEFFTGVKRNALAPDELIKWVHVKKATGPQEFSKVGTRNAMVIAVCAFGIALHPDTRTVRTGIGSAAPTPVRATAAEEFLNAALAEGGYWESGRTLPPALARQFAELAAGACNPIDDVRGSARYRRHAVGVMARRTLGWTWESYRRGAAGATRAEGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDN0</accession>
    <name>A0A0F7NDN0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransf_25 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_28290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018727.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH85493">
        <property type="protein sequence ID" value="AKH85493"/>
        <property type="gene ID" value="AA958_28290"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_28290"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5963"/>
    <dbReference type="OrthoDB" id="1664438at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="19"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="175" mass="18343" checksum="C26001BFAA019031" modified="2015-07-22" version="1">MDRHEWAARTLAVRPGDRVLEIGAGHGVTASHVCAELARGPRDGAPRFVGLDRSAKMTAAAGRRNAAHVAAGLAEFRTGAFPADLASWQPFDVAYAFNVRLLWTEPAAARAAAVLLRPGGRLSVFFQLPAWSAATHREVAARAARTLAAGGLAVTADGQDETVECGYVTARTPSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NEI8</accession>
    <name>A0A0F7NEI8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methylmalonyl-CoA carboxyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_30205</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019011.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_30205"/>
    <dbReference type="EnsemblBacteria" id="AKH85783">
        <property type="protein sequence ID" value="AKH85783"/>
        <property type="gene ID" value="AA958_30205"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_30205"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6378"/>
    <dbReference type="OrthoDB" id="886663at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="1">
        <location>
            <begin position="19"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="2">
        <location>
            <begin position="279"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH85783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="532" mass="57679" checksum="D2379E78BB1355B0" modified="2015-07-22" version="1">MTTVQEPVPARLRTETGVACERMQQYRRIRAQAHAGPSERATAAQRAKGKLTARERIDLLLDEGSFSEVEPLRRHRASGFGLEVKRPYTDGVITGWGAVHGRTVFVYAHDFRIFGGALGEAHAEKIHKIMDKAIAAGAPLVSLNDGAGARIQEGVSALAGYGGIFQRNTRASGVIPQISVMLGPCAGGAAYSPALTDFVFMVRETSQMFITGPDVVKAVTGEEITQNGLGGADVHAETSGVCHFAYDDEVTCLEEVRYLLSMLPQNNRENPPAVAAEDPADRGGEVLLDLVPADGNRPYDMRRVIEELVDDGEYLEVHERWATNLICALTRLDGQVVGIVANQPQSLAGVLDIEASEKGARFVQMCDAFNIPIVTLLDVPGFLPGVDQEHGGIIRHGAKLLYAYCNATVPRISVVLRKAYGGAYIVMDSQSIGADLTYAWPTNEIAVMGAEGAANVIFRRDIAAADDPDAKRAEMVKQYKAELMHPYYAAERGLVDDVIDPVDTRQILIRSLAMLRTKHADLPARKHGNPPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NEN8</accession>
    <name>A0A0F7NEN8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CopY family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_30490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BlaI transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019056.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_30490"/>
    <dbReference type="EnsemblBacteria" id="AKH85828">
        <property type="protein sequence ID" value="AKH85828"/>
        <property type="gene ID" value="AA958_30490"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_30490"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6443"/>
    <dbReference type="OrthoDB" id="2027769at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005650">
        <property type="entry name" value="BlaI_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34134">
        <property type="entry name" value="PTHR34134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03965">
        <property type="entry name" value="Penicillinase_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019455">
        <property type="entry name" value="CopR_AtkY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="122" mass="13567" checksum="8DAE6303FA631D11" modified="2015-07-22" version="1">MRRLGELEAEIMERLWGWGRPATARDVLADLNKTRPLAYSTVKTVADILHRKGVLRRAKNGRAWVYEPTLTRQEYTAALMQDALGSNPDPAGALMSFVEQMSSADVDALRSALRSAKRRAGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-08-12" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NES8</accession>
    <name>A0A0F7NES8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FMN-linked alkanal monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_31305</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">To bacterial alkanal monooxygenase alpha and beta chains.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019187.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH85959">
        <property type="protein sequence ID" value="AKH85959"/>
        <property type="gene ID" value="AA958_31305"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_31305"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6614"/>
    <dbReference type="OrthoDB" id="1003376at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019949">
        <property type="entry name" value="Luciferase_OxRdatse_group-1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03558">
        <property type="entry name" value="oxido_grp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="2">
        <location>
            <begin position="28"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH85959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="376" mass="39693" checksum="F0EA508CEB8BB1A6" modified="2015-07-22" version="1">MAAADVTAPDAQDEIRGRAGGSAPVPLSVLDLATVGAGYTATDALRTGVALARLAEARGFHRYWVAEHHSMPGVASSSPAVILAHLAAHTTAIRLGSGGVMLPNHAPLVVAEQFGTLEALAPGRVDLGLGRAPGTDGATAAALRRTDRLREGAEEFPQQLAELIRFLDDDFPDGHPYRRIHAVPGPVQGTAAGGVQSPHRPPVWLLGSSMFSARLAAELGLPFAFAHHFAGQHTGPALELYREAFQPSAVLSAPYALIGVSVMAAEDAREARRQVMAGALNMLRLRTGRPGLVPSPEEAESYEFSPLEREFADSWIGNVVYGTPDEVTTGLDDLRKRTGADELMLTTNVHGPAARLRSYDLIADAYDMPAAAAAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NEV1</accession>
    <name>A0A0F7NEV1_9ACTN</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_22535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_22535"/>
    <dbReference type="EnsemblBacteria" id="AKH86970">
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        <property type="gene ID" value="AA958_22535"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_22535"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4742"/>
    <dbReference type="Proteomes" id="UP000034283">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="129"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="207" mass="21713" checksum="A1F433EAE71A08BB" modified="2015-07-22" version="1">MFLAVAYFAVGQAAANRNDAQGAADAAALAAANDAREQLSDGLLDTLLDPGSWDDVIGGEGFEYGSACAAAQDFAAKNDADTTACDRVYDPDDGFTVTVRNREAVGDTLVPGTESKRSEATATAVLESRCDVQEPNGSGGEDDGRDQDDGGRGEGDGDGGRDDEDEDEDRDKPPLELDCEGGDWSLDPDDIDLLPDPDDLFSVRLVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFL4</accession>
    <name>A0A0F7NFL4_9ACTN</name>
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        <submittedName>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AA958_33085</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
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            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP011492">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_33085"/>
    <dbReference type="EnsemblBacteria" id="AKH86254">
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        <property type="gene ID" value="AA958_33085"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_33085"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6989"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519452" evidence="7">
        <location>
            <begin position="25"/>
            <end position="425"/>
        </location>
    </feature>
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            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="133"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="309"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="372"/>
            <end position="391"/>
        </location>
    </feature>
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        <location>
            <begin position="8"/>
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        </location>
    </feature>
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            <begin position="397"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH86254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="425" mass="42768" checksum="358E93E14495EF63" modified="2015-07-22" version="1">MATVSRRRRLSLSLMFLIPGLSLASWVTRTPDVRDELGASTAEMGLILFGLSVGSTIGIAGSGALVARMGTRPVIGGGTVLIALGVAGVGTGALASSAALVTAGLFVFGLGGGSGEVALNVEGAEVERLLGRSVMTALHGFFSLGTVLGASLGMLATAAGFPVQWHLIIMSGVALAVFLASFGDIPGGVGKPTATAEADAAEASEGAAGGRPLWQDTRLLLIGAVVLAMALAEGAATDWLPLLMVDGHDLDAALGSLVYVGFATAMTVGRFCGGFFIDRFGRYLVIRTSAISAALGLVVVIFVDHPVAAGAAVLFWGLGASLGFPVAISAAGDSGPNPTARVSMVAMIAYAAFLVGPPGLGFLGDHYGLRSAMIAVLALVATAIFLAPAVGERRPAVADVKNEPRAAPQGEKEPADDAACADRDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFM8</accession>
    <name>A0A0F7NFM8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP011492">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_28670"/>
    <dbReference type="EnsemblBacteria" id="AKH87091">
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        <property type="gene ID" value="AA958_28670"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_28670"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6042"/>
    <dbReference type="OrthoDB" id="1558246at2"/>
    <dbReference type="Proteomes" id="UP000034283">
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="SSF49452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="92"/>
        </location>
    </feature>
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        <location>
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            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="528"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="70"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH87091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="835" mass="85827" checksum="BF8CF86ADDFD1330" modified="2015-07-22" version="1">MGSWHVGTTLVNDEPVTVPAAGPAVGTAEPAQRPGRTGKGGPPAGSGAAPGAGAGDGDGDELSPWRVRLVFPALMLALLLAALEQMIVATALPKIVGELHGLDQMSWAITAYLLTSTISLPIYGKFGDLFGRKGVFQFAIVVFVAGSALAGASRSMDQLIAFRAVQGLGAGGLLIGVQAIIADIVPSRERGRYMGLIGASFGLASVAGPLLGGFFTDELSWRWCFYFNVPFGLVTLLVTGLVLKLPKPAARPRLDVLGGLFLAAASTCLVLLTSWGGLEYDWTSDVILGLGAGAVAATVLLLVVEHFAVEPVMPLRLFRDSIFNVTSLVGVVTGVAMFGAASYLPTFLQMVDGASATESGMLMLPMMIGTVAASITSGQLITRTGRYRPYPVAGCAVAAVGMWLLSRLDEDTSQLSYSIWMAVLGIGLGLVLPVLILAVQNAVRPADLGVATSAHNYFRQIGGSVGTAVFGTLFFDRLADELAGTLPPPPPGATLPEAESITPEAVHALDAELRDGYIRAYAEAMPGIFLYLVPVLVLGVVFAFLLKERPLVSQNHSGPGPATDEYPGVDTTVPAARGTVPAGAGVPVCGSVQHQDGTTVPRAALTLIDGAGRQVGRDASRDDGRYVLPTPGAGSYVLVAAAGGHQPQAVTVTVGDRPVELDLVLGGAGRICGTVAAADGTPLGNVVVTLTDARGEVVASARSSHDGSYAIGELVAGEYTLAATAPGFRPAALPVSVQAARETRQDVELAGGAVLRGTVRAYGGRPVEDARVTLLDAAGNVVDTGTTGPDGAFRFVDLSAGEYTVIAAGYPPVATVLRVEGGGRTERDLQLGHGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NG47</accession>
    <name>A0A0F7NG47_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peripla_BP_6 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_29735</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_29735"/>
    <dbReference type="EnsemblBacteria" id="AKH85717">
        <property type="protein sequence ID" value="AKH85717"/>
        <property type="gene ID" value="AA958_29735"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_29735"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6277"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028081">
        <property type="entry name" value="Leu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13458">
        <property type="entry name" value="Peripla_BP_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peripla_BP_6" evidence="2">
        <location>
            <begin position="38"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="435"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH85717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="474" mass="48903" checksum="F69DFEE2110C71C9" modified="2015-07-22" version="1">MVASLALVAAGCSGDDSSSGLPADEQSSAFSPKDGDGVRLGILGQCEGPFGGFHEDVAAGTTLAFARFAGASPNSSTSALKGFSGAEVEGTPIELVGIGCGDDTADRILQEVRRLVEQQGANVIIGPLSGDEGIAVAEYAKGKPDLTVFAGISGSQEQTLQVQAPNYFRFYGDGAIWNAGLGDLLYHEEGWRKVAVIADDYSFGHTSAAGFIADFCGVGGEVTHRVFPPLGTTDYSSYISQLPNPDEVDGYFWAVGGTGTQAALEAFVNAKGDLTGDEHAGNFFFNPDLAQALGTDIAGAHVGGFATLPGDIRTPEIEEYLAAADETWESIPGSLSGNDPAPPSTAAAFGFFYGYYTAGVALVEGLKAVDGDISDPQAFQAAVAGLTLDLPHGSISLDENRSGIVDVGLSRLVVDDSGEVVQESVAVVPGVDQTFGGTFSPDTPSPGRDFPACEKRDLPWEGKAIPVVDGAPQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NGB5</accession>
    <name>A0A0F7NGB5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Beta-ketoacyl synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_30260</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019020.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_30260"/>
    <dbReference type="EnsemblBacteria" id="AKH85792">
        <property type="protein sequence ID" value="AKH85792"/>
        <property type="gene ID" value="AA958_30260"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_30260"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6393"/>
    <dbReference type="OrthoDB" id="606297at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000794">
        <property type="entry name" value="Beta-ketoacyl_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712">
        <property type="entry name" value="PTHR11712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_KS" evidence="3">
        <location>
            <begin position="4"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH85792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="412" mass="42510" checksum="DD68778AD2C74D2A" modified="2015-07-22" version="1">MTAVAVTGLGIAAPNGLGTADYWAATRGGKSGIGRITRFDPSGYPARLAGEIPGFVDADHLPSRLLPQTDRVTRLALTAADWALADAGVDTGAFDPLDMGVITASHAGGFEFGQYELQSLWSKGSQYVSAYQSFAWFYAVNSGQISIRHGMKGPSGVVVTDEAGGLDALAQARRQIRKGTPLVVSGAVDASLCPWGWVAQLAAGRMSERDEPTRAYVPFDRDATGYVPGEGGAILVLEDAAAARARGARSYGEIAGYGATLEPGPEAGPGHADRGALRRSIEIALADAGLGTGDVDVVFADGAGVPEEDAAEAGTLCEVFGPRAVPVTVPKSMTGRLYSGAASLDVAAALLAMRDGVIPPTVHVDPCPEYDLDLVLHQARPAAALRHALVLARGHGGFNAAMVLRAHPTTTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NGP8</accession>
    <name>A0A0F7NGP8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_08340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019866.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_08340"/>
    <dbReference type="EnsemblBacteria" id="AKH86614">
        <property type="protein sequence ID" value="AKH86614"/>
        <property type="gene ID" value="AA958_08340"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_08340"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1760"/>
    <dbReference type="OrthoDB" id="1830049at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH86614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="201" mass="21475" checksum="A3914659BAF2817A" modified="2015-07-22" version="1">MASLLYDDSAPPPGPVQFQLVLLRRMQDFQPDLVAGALRALGVPRTAMREANRRWQGRLRARGGPAAGAARARDFAALLGPPVSVTRRAHGDMALDVHVWPVPLWPDLRFEATCGVGGVALNAWLVRAPDAAGPALRTLADLAPWGCTVDEVARAFPPAAPRETSAAPRFVLAFTAPDAAGEPRACTAEFAWGLVQRWGVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NGY6</accession>
    <name>A0A0F7NGY6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_11770</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_11770"/>
    <dbReference type="EnsemblBacteria" id="AKH86699">
        <property type="protein sequence ID" value="AKH86699"/>
        <property type="gene ID" value="AA958_11770"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_11770"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2474"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="6"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH86699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="329" mass="36956" checksum="8F12564D2FC1B6AD" modified="2015-07-22" version="1">MQDFAQDTLRSLARNARSGREFILVDDCSTDATPQIVDRAAKTLPGARVIRHETNQGIARARNSGIDAARGDYLTFLDGDDWYAPGYLDDLIAAMDRYGTDFVRVDHVQSNGRDRVVRRAPARRRDTILAARDGIGQANLETMVDYPFVWAGIYHRRLFKDGAGRFAAELRTAEDRLWTWMLHLTAETFAVTGLLGVFYRRGVKTSLTQISDDRQLDFIPAHDAMLDAVLADPDADRFLPKAVRTYCALIAFHRGNSERLEPGLARRLERASAEALRRMPQDVLEETLRGMDEQRARMLRQLRASGRGKPGKPGGQGTQDRTGKPERVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NH46</accession>
    <name>A0A0F7NH46_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_14545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="AA958_14545"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_14545"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3062"/>
    <dbReference type="OrthoDB" id="1143444at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="319"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="599" mass="67453" checksum="D5BF6C53D4DBA7D0" modified="2015-07-22" version="1">MISDAIAHGHDNAEVRFHWVLAMLSTRAYHDLSAEELQRLRHACGLIETYAEGEWKDALRVVFELLAMRSTADGETGHVLERLLALSPRQRDAILHHLDLVLSGGLKDSLWAEYRERAEGARFGNDRGQRVWAYFEPDPIGPRALPPRPSTAAAAQAALKVPAGLFVIATAFFCTLALVADPAAAVIELLVALGAGLTAAYSGRRWWYQVYRLKEKKRAPHIPHAGASVSTGDGFTNRVRHSFDYYFSTRVPYGSAPHEWLARTVHIRYSLAAEIALLYRESRISVDRVNWLIRYLAEDARDRHDRGTLFDHRPNHTPAAAALCVVALITLGVTTLTLLGTVASGIGASQMLLALLAVVGAVWSGRAAASSWLESWGEERRLAEETQEYEEQLTARQVAYQKWKSFLEFTRPSELEMETWLTCDKTLFVDEALRHYQLAWRDLVTHTILMTPARPYKRGRVKGGPWRYSRYSFRLFLVTQDGVREISTEFDFTDAKRGNEQRSNYRFDALSSVQVTERTHVGYDLELILTNGPARNIRVKDADTHQLTPDENAHEIAEINLDAAGFVHTFRLLEGIAADGKSWIERNNPNNLPPFRAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NHE1</accession>
    <name>A0A0F7NHE1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl-CoA hydratase 2</fullName>
            <ecNumber evidence="1">4.2.1.119</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Enoyl-CoA hydratase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_12540</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3R)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:26526"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57319"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="EC" id="4.2.1.119"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="4.2.1.119" evidence="1"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019993.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_12540"/>
    <dbReference type="EnsemblBacteria" id="AKH86718">
        <property type="protein sequence ID" value="AKH86718"/>
        <property type="gene ID" value="AA958_12540"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_12540"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2635"/>
    <dbReference type="OrthoDB" id="942354at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MaoC-like" evidence="6">
        <location>
            <begin position="195"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="151"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH86718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="300" mass="31675" checksum="264FB81D70CE5D82" modified="2015-07-22" version="1">MVPKRRGRAYGTGAGAGGAGEAGPEAGAGLPAVPQRRLVLRDVRPDPARLRRYAAVCGFPDDGRLPVTYPHVVAFPLAMSLMTARDFPFPLLGLVHLANRVEHLRPVDAGERLTYVVATGRARPHPKGTAFPVAAHARLRGETVWRSTSTYLSRGPRTGTGTGSGEPPAEASGAPEVTAAAREESWRLPGSLGRSYAAASGDRNPIHLHPLTARPFGFRRAIAHGMWTKAHCLAALAADLPAAYAVEVSFRAPVLLPAAVRFRAERAERAEHAAGGWAFDVRGADGDRAHLRGAVSPLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NHP7</accession>
    <name>A0A0F7NHP7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_16715</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_16715"/>
    <dbReference type="EnsemblBacteria" id="AKH86828">
        <property type="protein sequence ID" value="AKH86828"/>
        <property type="gene ID" value="AA958_16715"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_16715"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3516"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="237"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="274"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="307"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="339"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="370"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="403"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="445"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="19"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH86828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="474" mass="47849" checksum="29B4DE5B9B51B60F" modified="2015-07-22" version="1">MTAASAAAGPGAGGRRGPALVVLCFVQFMLVVDDNVVSVALPTVRDDLGFSTPGLAWVVNAYFLAFGGLLLLFGRMADLLGRRRIFLTGVTVFGAASLLCGLAQEPWHLVAGRFAQGAGAAMASPAALALIALLYPGTRERARAFGIWGGIAGLGGTAGLVISGALTGLASWRWIFLINLPVALAAVVLLPRLEPESRAARAARLDVPGAVLGTGALVSLVYGLLRSAESGWGDPGTAGPLVLAALLAAAFLAVEARTAEPLVPLSFLAFRFRAVANGATLLFSAAMYAMAFLLMVHLQTVLGYRPLAAGLAYLPYGGGILIGMWLSSRAVTRLGARPALVLSFLITAAGLLLLAGVAPSDGYGSGVLPGMLLTSLGCGLSLPALTVAALTGTTGENAGLGSAVLTSVQQVGGAVGVAVFVGLATRRRDDLTAGHDPLHAATEGFSTALTTAAALLTLGAILIAALLRAPAVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NHZ2</accession>
    <name>A0A0F7NHZ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA polymerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_19265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020236.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_19265"/>
    <dbReference type="EnsemblBacteria" id="AKH86898">
        <property type="protein sequence ID" value="AKH86898"/>
        <property type="gene ID" value="AA958_19265"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_19265"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4052"/>
    <dbReference type="OrthoDB" id="1581397at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030931">
        <property type="entry name" value="Group_II_RT_mat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013597">
        <property type="entry name" value="Mat_intron_G2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08388">
        <property type="entry name" value="GIIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04416">
        <property type="entry name" value="group_II_RT_mat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="95"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="487" mass="54679" checksum="517C56D25ECC6BA8" modified="2015-07-22" version="1">MPGGALVNTGGPGFGDLVYEAERRVLGIQNKLHRWACEDRHRRFDDLFNLVCDPAFLVVAWARVRSNKGARSAGVDGRSASVIEAQGVEGFLDGLRQGLKDQSFHPLPVRERTIPKAGGKLRRLGIATITDRVVQASLKLVLEPIFEADFLPCSYGFRPNRRAHDAVAEVRHFASRTYEWVLEGDIKACFDEISHSALMGRVRGRIGDKRVLSLVKAFLKAGILTEYGALEDTDAGTPQGSILSPLLSNVALSVLDEHIAQAPGGPGTSDWQRRVRRRTGLANFRLVRYADDWCLMITGTRADAEGLRDEIAAVLSTMGLRLSVDKTLITHIDEGLDFLGWRIQRHRKKGQHEQSDRRYVYTYPAKKALRAICRKVKTICRTTNIDQPLSVLLHRLNPVLRGWCAYFRPGVSSKTFGYLASVTWRQVLAWLRRKHRKTGWKTLRRRYCAGGWWPSDGDVKLLHTGSISTTRYRYRGAVIPSPWTATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NI34</accession>
    <name>A0A0F7NI34_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Amino acid ABC transporter ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_34070</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019649.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_34070"/>
    <dbReference type="EnsemblBacteria" id="AKH86427">
        <property type="protein sequence ID" value="AKH86427"/>
        <property type="gene ID" value="AA958_34070"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_34070"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.7199"/>
    <dbReference type="OrthoDB" id="1475841at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032823">
        <property type="entry name" value="BCA_ABC_TP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12399">
        <property type="entry name" value="BCA_ABC_TP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH86427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="237" mass="25211" checksum="B4F6F6827A4CCE90" modified="2015-07-22" version="1">MSTVLDIKGLEVVYGKVEALRGLDLTVGENEIVALLGNNGAGKSTTVSTISGVVRPRVGSITAYGDDITVATPWSIVQRGIVHVPEGRRIFSRLTVHENLQLGGYTVKDGATIDKRINRVYELFPRMAERRNQQGGTLSGGEQQMLAIGRAMVGGPRLIMLDEPSMGLAPLVVAQVMDAIVSINQAGTSVLLIEQNARAALKIAHRGYVIDSGRVKVAGAADQLRADPQVVEAYLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NI56</accession>
    <name>A0A0F7NI56_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Selenocysteine-specific elongation factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_30010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020546.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_30010"/>
    <dbReference type="EnsemblBacteria" id="AKH87134">
        <property type="protein sequence ID" value="AKH87134"/>
        <property type="gene ID" value="AA958_30010"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_30010"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6336"/>
    <dbReference type="OrthoDB" id="244339at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001514">
        <property type="term" value="P:selenocysteine incorporation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015191">
        <property type="entry name" value="Elong_fac_SelB-wing-hlx_typ-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09107">
        <property type="entry name" value="SelB-wing_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="1" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="2">
        <location>
            <begin position="1"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH87134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="592" mass="61476" checksum="ABAA459B935F1D7F" modified="2015-07-22" version="1">MIATAGHVDHGKSTLVRALTGTDPDRLAEERRRGLTLDLGFAWTTAPGGRTLAFVDVPGHHRYLATTFAGIATAPAVLLVVSAEEGWRPQTAEHLAALDAFGVRTGLLAVTRADLADPAPTLAEAAERTSGTGLAGAPAVAVSARTGEGLDRLLRELDALAAALPPPDPAAPVRLWLDRAFTVAGAGTVVTGTLSAGTLAEGDTLHLAPAGRAVQVRGLHSLGHAVPRVTGPARVAVNLRRIAADQVRRGNALLTPGRWWTTDLVDIRCEPTGGTDDGGAPPRLPAEPLVHCGTAATSARLRPLGLDTARLALRTPLPLHVGDRLLLRDPGSRLLAGATVLDPEPPPLTGRGAAATRARLLAGISEPTDPAVRLAAAGLGDRGRLTAQGYAVDADGERWLFDRAYAERLAAALAAAVKEHAGAHPADPGLPVARARQLLALPPDTALAGLAAVAGAGLTLRDGRLYRAEEADRLPAAVAAGLERLLDEVRSAPFQAPTRRRLDELGLDAEALALLVRRGALERVGTVHLPAGSVGRAARELAGLPQPFTVSEAARALAVSRRVAIPLLETLDETGHTHRRPDGRRVLKDDPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NIB2</accession>
    <name>A0A0F7NIB2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_02100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_02100"/>
    <dbReference type="EnsemblBacteria" id="AKH86502">
        <property type="protein sequence ID" value="AKH86502"/>
        <property type="gene ID" value="AA958_02100"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_02100"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.452"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013211">
        <property type="entry name" value="LVIVD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08309">
        <property type="entry name" value="LVIVD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519548" evidence="2">
        <location>
            <begin position="33"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH86502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="489" mass="52701" checksum="8F751B2DA04A1856" modified="2015-07-22" version="1">MHRSRTRRRGLAAAAALIGLVGSLLTAGTAAAVPDPGDGPNAPKKLSSSERSQAQEAIERGDVPGVDEIDNSDNIEHVAHLDKGALQGTNSDIAFQGRYAFAGNYDGFVIYDIADPKSPEVVSEVLCPGSQNDVSVSGDLLFLSTDSSRSDDSCNSTTQPATEKDSWEGMKVFDISDKRNPEYVAAVETACGSHTHTLVPERKNVYLYVSSYSPSATFPDCQPPHDGISIVKVPRSAPERSEVIDFPVLFPDGGNPGSPGKSATTGCHDITAFPKLDLAAGACMGDGILMDISDPAAPEVIDQVSDYENFAFWHSATFSKDGQKVVFTDELGGGGAATCNEEIGPKQGANGIYDLKQRGTKSELIFRSYYKIPRHQADTENCVAHNGSLVPVAGGRDIMVQAWYQGGVSVWDFTDSRNPKEIGYFERGPLSDTSLVTGGSWSAYYYNGYVYSNDIAKGLDVLKINDRRTDSARWVRLPELNTQTQPDYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NIE1</accession>
    <name>A0A0F7NIE1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methylmalonyl-CoA carboxyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_25645</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020409.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_25645"/>
    <dbReference type="EnsemblBacteria" id="AKH87033">
        <property type="protein sequence ID" value="AKH87033"/>
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            <begin position="22"/>
            <end position="278"/>
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        <location>
            <begin position="282"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AKH87033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="535" mass="57647" checksum="0C7E7B985E882161" modified="2015-07-22" version="1">MTTVDYAPSDAAATAGAVENEARGRAAELRRIREQAHAGPSERATAAQRAKGKLTARERIDLLLDEGSFSEVEPLRRHRASGFGLEVKRPYTDGVITGWGAVHGRTVFVYAHDFRIFGGALGEAHAEKIHKIMDKAIAAGAPLVSLNDGAGARIQEGVSALAGYGGIFQRNTRASGVIPQISVMLGPCAGGAAYSPALTDFVFMVRETSQMFITGPDVVKAVTGEEITQNGLGGADVHAETSGVCHFAYDDEVTCLEEVRYLLSMLPQNNRENPPAVAAEDPADRGGEVLLDLVPADGNRPYDMRRVIEELVDDGEYLEVHERWATNLICALTRLDGQVVGIVANQPQSLAGVLDIEASEKGARFVQMCDAFNIPIVTLLDVPGFLPGVDQEHGGIIRHGAKLLYAYCNATVPRISVVLRKAYGGAYIVMDSQSIGADLTYAWPTNEIAVMGAEGAANVIFRRDIAAADDPDAKRAEMVKQYKAELMHPYYAAERGLVDDVIDPVDTRQILIRSLAMLRTKHADLPARKHGNPPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NIP3</accession>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_30735</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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    </dbReference>
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    <dbReference type="PATRIC" id="fig|444103.5.peg.6496"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Prenyltransferase_CloQ"/>
    </dbReference>
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        <property type="entry name" value="PrenylTrfase-like_sf"/>
    </dbReference>
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        <property type="entry name" value="PTase_Orf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143492">
        <property type="entry name" value="SSF143492"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH87153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="280" mass="30835" checksum="6E0F39DFA74DE03F" modified="2015-07-22" version="1">MDAPCAREKIWPALDTFGKWLVDDAHIIFSMGTGERYRGELAFDFTLPTEAGDPYAAAVAGGLLEETDHAITGLFTEIRDRFPVDAYAVDFGVVGGFRKAVTFFPLAKPQSMKALTELPSIPPGLAAHADSFAEAGLDGKVSAIGVDYRSRSWNLYVSGLTPEYTRPDALIPTLRDMGLPEPSEHMLEFIGTSYAMYPTFGWDTTRIERMCFSTRTSDPDLLPSRIAPEVGRFARDMPTVHGGEPSYVYAGTVARGEEFFKLASYYQMSSQVSDRVRPAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NIS9</accession>
    <name>A0A0F7NIS9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Puromycin resistance protein pur8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_12420</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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        </lineage>
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    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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                <person name="Albersmeier A."/>
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                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_12420"/>
    <dbReference type="EnsemblBacteria" id="AKH86712">
        <property type="protein sequence ID" value="AKH86712"/>
        <property type="gene ID" value="AA958_12420"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_12420"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2610"/>
    <dbReference type="OrthoDB" id="1108236at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EmrB-like"/>
    </dbReference>
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        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="272"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="307"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="336"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="361"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="457"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="15"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="484"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH86712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="506" mass="52653" checksum="57F0878BCDAD11FF" modified="2015-07-22" version="1">MPETALQPDPRRWKALAFIAVAQLMVVLDATIVNIALPSAQEDLGISDANRQWVITAYALAFGGLLLFGGRIADLWGRKRTFITGLVGFAIASALGGAATGQAMMFGARALQGVFGALLAPAALSLLAVLFTDGKERAKAFGIYGAIAGGGGAVGLILGGVLTEYLDWRWTFFVNIPFAVVAVLGAMAVIHDPKGSRNRSPLDIPGVLLATTGLVALVYGFTRAESEGWTDTLTIVMFVASVVLLAAFVAVEAKVKSPLLPLRVLLERNRGGVYLSLGLAVIAMFGVFLFLTYYLQVVKGYSPVKTGLAFLPMIVGMIIGSTQIGARLMTRVQPRLLLVPGFLTGALGMLLLAQMEPGSSYAALVLPALVLLGLGLGTAFMPAMSLATYGVEPRDSGVASAMVNTSQQVGGAIGTALLNTIAASATTDWISSHASEARTLGREGFANSAAVHGYSTAIWWAVGILVVSAALAYTLVTARAQSGHEVSGDGKDAGTEDEVQAPVMVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NIW0</accession>
    <name>A0A0F7NIW0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_33305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="AA958_33305"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_33305"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.7034"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH87208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="79" mass="7890" checksum="5BF987B945EA14AE" modified="2015-07-22" version="1">MPAATTGTRRTPAADREPDPVPPPMPPPTPPAPPGRGPDPRPGPGPGPGPQPPPEPDPIPRPPGPDPVPEPDPQPGPVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NIX8</accession>
    <name>A0A0F7NIX8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_14640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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            <authorList>
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                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
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            <begin position="28"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
    <sequence length="143" mass="15229" checksum="F09A682EEFCAF60A" modified="2015-07-22" version="1">MVMAMTRTRSLLVPAALLAAALTACGGSDDAADRSDRGEEPSSSSAAPAPSATSHEAVCVRLITYWAHDQLKPGGGSQSDYQQKGLSDGQNTILLDVVEQAREERRNNGDAAARKLVEREVKKRCAERYEGEGSDAPSAGWPR</sequence>
</entry>
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    <accession>A0A0F7MZ06</accession>
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                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
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        </subcellularLocation>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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    <feature type="transmembrane region" description="Helical" evidence="6">
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    <feature type="domain" description="SSD" evidence="8">
        <location>
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            <end position="698"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH80956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="744" mass="75974" checksum="57F20F3744E7888A" modified="2015-07-22" version="1">MATFLYRIGRWAFRRRRLVGGTWLVALVLAGVAAAAAPAGEEEDLSMPGTESQEAFDLLDERFPESNAQGAEARLVFRAPDGQRVTAQEHKAAVADALGSLAGGGQVASATDPYEAGDVSKDGTIAYSTITYTADAVDLTGSAKSALEDAADQARDAGLTVETGGSALDAEEEPGGTTEIIGVAVAAVVLVLALGSLVAAGLSLLTAFAGVAIAFGLVSALAVPLGLTSTVAILALMLGLAVGIDYALFITSRFRDELARGSEPEEAAGRAVGTAGAAVVFAGATVFIALVGLGVVGIPELTKMGMGGAGAVALAVLVALTLVPAMLGFAGRRVLSRAARKAARRAGERPHAVPPASGRPGLGVRWARFVLRRPVAVLLVAGLGLGAVAVPALGLELGLPGDESKSVETTQRRAYDLLSEGFGPGFNGPLTVVVDTSEAVDTEAATGRVAETVRELDGVASVGDPVLDEAGETALFTAVPETAPNSGETKDLVNSIRDEAAGVEADTGADVLVTGTTAMNIDISAAMSDALLPYLTVVIGLAVLLLTVVFRSILVPLKAALGFLLSVGAAFGVLVAVFQWGWGADLLGIEQTGPVMSLMPILIIGIVFGLAMDYEVFLLTRMRETYVHGASPAEAIVHGFRHSGRVVAAAAIIMISVFAGFVGMSSPTIQTMGVGLAAAVAFDAFVVRMAIVPAVLALLGHRAWWLPRILNRVLPNVDIEGEALSGRAPAPVSGSVPRLPAGRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-10-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MZJ0</accession>
    <name>A0A0F7MZJ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_01885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014490.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH81126">
        <property type="protein sequence ID" value="AKH81126"/>
        <property type="gene ID" value="AA958_01885"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_01885"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.409"/>
    <dbReference type="OrthoDB" id="1681849at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023187">
        <property type="entry name" value="Tscrpt_reg_MarR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01117">
        <property type="entry name" value="HTH_MARR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="131" mass="14204" checksum="353EA0B3DF66A495" modified="2015-07-22" version="1">MATGSAEGAVVSQWREIRAVHARAVGELDRELHRYGIGASDFEVLDVLLGMANSGDRASLRVQELADRVHLSQSALSRLVGRLEKHGLVTRGMCPEDRRGVQVCVTDAGRTLHAEALPVQRAVLARTVGIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N044</accession>
    <name>A0A0F7N044_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Response regulator receiver protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_06695</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015302.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_06695"/>
    <dbReference type="EnsemblBacteria" id="AKH81950">
        <property type="protein sequence ID" value="AKH81950"/>
        <property type="gene ID" value="AA958_06695"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_06695"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1397"/>
    <dbReference type="OrthoDB" id="930905at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="145"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH81950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="214" mass="22901" checksum="387DCB1285B0E3ED" modified="2015-07-22" version="1">MVVDDHPMWRDAVARDLAAAGFDVVATAGDGPQAVRRARAAAPDVLVLDLNLPGLPGVQVCKEVLGAQPGVRVLVLSASGEHADVLEAVKSGATGYLVKSASTEELTDAVHRTAQGDPVFTPGLAGLVLGEYRRLAGEPVAENADEPEVPKLTDRETEVLRLVAKGLSYKQIAERLVISHRTVQNHVQNTLGKLQLHNRVELVRYAIERGLDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N051</accession>
    <name>A0A0F7N051_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AA958_06805</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015322.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_06805"/>
    <dbReference type="EnsemblBacteria" id="AKH81970">
        <property type="protein sequence ID" value="AKH81970"/>
        <property type="gene ID" value="AA958_06805"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_06805"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1423"/>
    <dbReference type="OrthoDB" id="692375at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519627" description="Histidine kinase" evidence="8">
        <location>
            <begin position="22"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="175"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="10">
        <location>
            <begin position="199"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="262"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AKH81970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="471" mass="51776" checksum="F31E0E52F734E62A" modified="2015-07-22" version="1">MISARARILLLLLVVMAAALAAVAGTTRSILLRDLEHRVDRLLAQETREFASLYERGVDPETSRPFTDPERLLTVFLERQYADPDEELLGLVRQRGDGPKQLVQPRDLTMSRQLENDKAGRRTIFESGDRTGFLDRPSGEVRWAKAGIGAKEEPDAAAFVVAIHTEREREQVSDVFVIMLMISAMALVVVSAIGWAVAGRILAPVRLVGQTAAQLTEQDLTRRIPVRGRADRDETAALAATFNAMLDRLERAFAAQREFVDDAGHELRTPITIVRGHLELMGEDPAEREETLRLVTDELDRMTRIVEDLLLLAKAERPDFVQPEPVQLAELTADVFVKARTLGERDWELSEVAEGETRLDPQRVTQAMVQLAQNAVQHTAPGGRIRIGSRTAEGHVELYVADSGPGIPPQDAGLIFERFRRGTARRGSRGGGAGLGLAIVRAIAEGHRGHVELSPTDGGGATFTLILQEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N084</accession>
    <name>A0A0F7N084_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_07100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_07100"/>
    <dbReference type="EnsemblBacteria" id="AKH82025">
        <property type="protein sequence ID" value="AKH82025"/>
        <property type="gene ID" value="AA958_07100"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_07100"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1488"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH82025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="83" mass="9334" checksum="2F388B3B2E5BE155" modified="2015-07-22" version="1">MPVAYAPTPLPKKPLPAGMPREWYVAHNRMLKAMRIAIALLDTGVYTPQRARNEVIRHTAERIGVHPPSLTTCRLVRSLLPLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0M6</accession>
    <name>A0A0F7N0M6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Endoribonuclease L-PSP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_00520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH80899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014265.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH80899">
        <property type="protein sequence ID" value="AKH80899"/>
        <property type="gene ID" value="AA958_00520"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_00520"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.120"/>
    <dbReference type="OrthoDB" id="1850770at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="PTHR11803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="SSF55298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH80899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="133" mass="14150" checksum="360A916CB3495DF2" modified="2015-07-22" version="1">MATTDAFHHGVAAENDFGYAQAIRSGELIHVSGQVAFDEAGEFAHADDCAAQLTLTYANLDKVLEHYGATRNQIVSQTVYGVRLQQNAEAISAGNLAYFGAHRPASTVVGVTELAFPGQLVEIAVVVYTRLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N143</accession>
    <name>A0A0F7N143_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_01680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014453.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_01680"/>
    <dbReference type="EnsemblBacteria" id="AKH81089">
        <property type="protein sequence ID" value="AKH81089"/>
        <property type="gene ID" value="AA958_01680"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_01680"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.368"/>
    <dbReference type="OrthoDB" id="710201at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH81089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="490" mass="52925" checksum="7224B2DF21217F58" modified="2015-07-22" version="1">MSKGPNTRLADLFGMTGWSKGELARLVNRQAAATGHPQLSTDTSRVRRWIETGEIPREPVPKVLAVLFTERLGRVVTTEDLGFERAGGPGRVRRQSDDALPWAPERTAEVLTEFTGMDLMLNRRGLVGAGSALAAGSALTSSLHEWLHSDPAAPGTAAGSGTPTVEPARYGRYEATPVGAQEVDALERSVEVFRAWDAERGGGLQRKAVVGQLNEVGGMLAYRHPEPLQSRLWGVAANLAVLAGWMSHDVGLEPTAQRYFVIAAHAAREGGDRPRAAEALSRAARQMIHLGRPDDALELIGLAKSGTGTGTHPRTRSMLHTIEAWAQAAKGRTGAVQRTLGEAEDLFAADGKDAAAPTWMQLFDEADLHGMQALAYRTLAEHDPSAALRACEHGELALAKRPDGRQRSQILDYVSLAAAGFLADDPDRGEDYARLALERIGENSSHRTWDRLRETCRLTAPFSDDPVVKALREEMSETLAKAPKGRTSPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N155</accession>
    <name>A0A0F7N155_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_01765</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014468.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_01765"/>
    <dbReference type="EnsemblBacteria" id="AKH81104">
        <property type="protein sequence ID" value="AKH81104"/>
        <property type="gene ID" value="AA958_01765"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_01765"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.385"/>
    <dbReference type="OrthoDB" id="1664438at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_12" evidence="1">
        <location>
            <begin position="99"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="261" mass="30162" checksum="A068655E9163F4A1" modified="2015-07-22" version="1">MPRKNLTANRTTLTHRVRYAARHPDRVPRYLARAGRDAWLRLRHPRDHVAYYRAVMRSDSAADPEAAVGSKSHDRWLALGKMQFDYLVEHGLRPGDPMLEIGCGNLRAGWRFIDYLERGRYYGLDISPDILFAAQDTIVRHDLQDKLPRLTPVRDLTFAFLPAAHFRVVHAHSVFSHSPPGVIDECLAHVGRVLRPDGWFDFTFDRTETEEHHVLREDFYYRTETLVALAEKHGLRAEFMADWEKLPHGQSKIRVRPPAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N176</accession>
    <name>A0A0F7N176_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glucose-6-phosphate 1-dehydrogenase</fullName>
            <shortName evidence="5">G6PD</shortName>
            <ecNumber evidence="5">1.1.1.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">zwf</name>
        <name evidence="9" type="ORF">AA958_05635</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>D-glucose 6-phosphate + NADP(+) = 6-phospho-D-glucono-1,5-lactone + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:15841"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57955"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="EC" id="1.1.1.49"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the glucose-6-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.49" evidence="5"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015120.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_05635"/>
    <dbReference type="EnsemblBacteria" id="AKH81766">
        <property type="protein sequence ID" value="AKH81766"/>
        <property type="gene ID" value="AA958_05635"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_05635"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1180"/>
    <dbReference type="OrthoDB" id="1153269at2"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00408"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004345">
        <property type="term" value="F:glucose-6-phosphate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00966">
        <property type="entry name" value="G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001282">
        <property type="entry name" value="G6P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019796">
        <property type="entry name" value="G6P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022675">
        <property type="entry name" value="G6P_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022674">
        <property type="entry name" value="G6P_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23429">
        <property type="entry name" value="PTHR23429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02781">
        <property type="entry name" value="G6PD_C"/>
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    </dbReference>
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            <begin position="27"/>
            <end position="210"/>
        </location>
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            <begin position="212"/>
            <end position="507"/>
        </location>
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        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
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        <location>
            <begin position="106"/>
            <end position="107"/>
        </location>
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            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
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        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
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        </location>
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        </location>
        <ligand>
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        </ligand>
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        <ligand>
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        </location>
        <ligand>
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        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
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    </evidence>
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        <source>
            <dbReference type="HAMAP-Rule" id="MF_00966"/>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02781"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AKH81766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="509" mass="57469" checksum="783D8FB2C43C11E3" modified="2015-07-22" version="1">MTGSESNPLRDPQDRRLPRIAGPSGLVIFGVTGDLSRKKLMPAVYDLANRGLLPPGFSLVGFARRDWEDEDFAQVVHDSVKEHARTPFREEVWQQLSEGFRFVQGDFDDDEAFERLRTTVEDLDKARGTGGNFAFYLSVPPKFFPLVVQQLKEHHLADPAGDSWRRAVIEKPFGHDLKSAEELNRIVHEVFEPDQVFRIDHYLGKETVQNILALRFANTMFEPIWNRSYVDHVQITMAEDIGIGGRAGYYDGIGAARDVIQNHLLQLLALTAMEEPTAFDAQALVAEKTKALESVRLPEDLGRHTVRAQYTAGWQGGEKVRGYLEEEGIDPHSGTDTYAAIKLEIDNRRWAGVPFYLRAGKRLGRRVTEIAVVFQRAPHLPFDTTDTMELGQNALVIRVQPDEGITVRFGSKVPGTSMEVRDVTMDFAYGESFTESSPEAYERLLLDVLLGDANLFPRPQEVELSWKILDPIEEHWARHGKPASYTAGTWGPKAADEMLARDGRSWRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N1B9</accession>
    <name>A0A0F7N1B9_9ACTN</name>
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            <fullName evidence="2">Fe-S osidoreductase</fullName>
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        <name evidence="2" type="ORF">AA958_02235</name>
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    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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    </dbReference>
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        <location>
            <begin position="3"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="CCG" evidence="1">
        <location>
            <begin position="126"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="238" mass="25657" checksum="FB0F9D9E7964EDBB" modified="2015-07-22" version="1">MRVALFVTCVNDTLYPRTGRAVVALLERLGVTVDFPLAQSCCGQAQFNTGYLGETRPLARRYADVFADYEYVVSPSGSCAAMVRDNYPRIGEPAAAAVAPRTYELTEFLTDVLDVTDVGAYYPHTVTYHPTCHGLRVLRLGDRPRHLLEQVKGLTLHELEGADECCGFGGTFALKNPAVSAAMGADKARHVEESGAQAVCAADNSCLMHIGGTLARRGSPVRPVHIAEILASTEGDVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N1M5</accession>
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        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">AA958_02800</name>
    </gene>
    <organism evidence="1 2">
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
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    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_02800"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.599"/>
    <dbReference type="OrthoDB" id="1356861at2"/>
    <dbReference type="Proteomes" id="UP000034283">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH81279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="262" mass="26366" checksum="0A5FBC174812BD76" modified="2015-07-22" version="1">MTAQTGEDPGGRFAGRTAVVAGASEGIGLAVAAGLVAGGANVVLVARREDVLAEATAKLGPAASGVAGDVADETTAARAVAHAVDTHGGLDLLHFNAGTLLPGDIAGQPLDHVDRMLAVNLRGPITFVRAAAPELAKRPGAAVTLTSSATGRLPVPGLGVYGATKAALHYLVSTWAIELAPSGIRVNALCPGGTYTPSMYEAAKAIPGLEEATIATNLVKRMATPEEIARPALTLLDSAESGYVTGAVWDIDGGYQRDRSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N1W9</accession>
    <name>A0A0F7N1W9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_03580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_03580"/>
    <dbReference type="EnsemblBacteria" id="AKH81418">
        <property type="protein sequence ID" value="AKH81418"/>
        <property type="gene ID" value="AA958_03580"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_03580"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.754"/>
    <dbReference type="OrthoDB" id="1054546at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="48"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="323" mass="34321" checksum="B0AAB3909CEDC403" modified="2015-07-22" version="1">MAFDRLTEVTTPAAHIGFGLAAVGRPAYLTTGRAEDLPAGRGVEEMRARTHELLDAAYAQGVRYFDAARSYGRAEEFLADWLKQHPDARDAVVGSKWGYAYVGDWRADAEVHEVKDHGVDAYDRQREESAELLGDRLDLYQIHSLTPDSPALTDTDLHRRLAALAANGVTVGFSTSGPEQAAAVRAALEVTVEGERLFDTVQSTYNVLEPAVGEALAEAHDAGLTVIVKEGLANGRLAGADAPAELRAVAAECGAEPDAVALAAVLRQPWAGVVLSGAATAAQLHSNLAAAAVDLDPAQYDRVAALAEPAADYWQRRAATPWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N1Z5</accession>
    <name>A0A0F7N1Z5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Acetylglutamate kinase</fullName>
            <ecNumber evidence="7">2.7.2.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">N-acetyl-L-glutamate 5-phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">NAG kinase</fullName>
            <shortName evidence="7">NAGK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">argB</name>
        <name evidence="9" type="ORF">AA958_03635</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamyl 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:14629"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:57936"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 2/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the acetylglutamate kinase family. ArgB subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.8" evidence="7"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014787.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_03635"/>
    <dbReference type="EnsemblBacteria" id="AKH81429">
        <property type="protein sequence ID" value="AKH81429"/>
        <property type="gene ID" value="AA958_03635"/>
    </dbReference>
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    </evidence>
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    </evidence>
    <sequence length="316" mass="33243" checksum="1FFF626D72D0482F" modified="2015-07-22" version="1">MTTTSAPAAAPATPTRKHTALPKARTLIEALPWLTRHHGKVVVVKFGGNAMVDDDLKRAFAQDVVFLRHAGLRPVVVHGGGPQISAQLDRHGLASEFRAGLRVTTPEAMAVVRMVLAGQVQRELVGLLNEHGPFAVGLTGEDAHTITATRHRPLVDGEPVDIGRVGEVTDIDTGAIEALLADGRIPVVSSVARSADESDAAGEVFNVNADTAAAALAAALGAETLMVLTDVEGLYENWPDSDEVISRLTAGELERLLPDLASGMVPKMEGCLYAVRHGVHTARVIDGRVPHSILLEIFTDEGIGTMVVPDAEGAAT</sequence>
</entry>
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    <name>A0A0F7N250_9ACTN</name>
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        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
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</entry>
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    <accession>A0A0F7N286</accession>
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    </gene>
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        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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                <person name="Winkler A."/>
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                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="AKH82715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="399" mass="43684" checksum="C939BF405B01DEC7" modified="2015-07-22" version="1">MTTKVSLSADDARRIALRAQGLLGAPDRRAGARGVLRRLGAVQLDTISVLARSHELVPYARLGAIGREAVESAYWSGTTAFEYWSHAACILPIEEWPLFAFRRRDRRARGYRWHRLQDPEGSRAAVVDRLRAEGPLTSTDLGGAKKGGPWWDWSETKIAVETLLDAGEVVVTARRGWKRVYDLAERAVPDALFHDDVPDEECMRRLVAQAGRALGVATRADLADYHRLKGEQVAAVLGDTELVEVEVEGWGKPAWADPEALADAPRGRHRTTLLSPFDSLIWDRPRTERIFGLTHRLEAYVPKPQRIHGYFAMPVLAGGRLVGRVDPGREGNTLVARQVTLGADRPNGVTPAKAVEPTAAALAEAATWVGAQSVRVERVSPPELHTPLARAAEKAVAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2D8</accession>
    <name>A0A0F7N2D8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_07880</name>
    </gene>
    <organism evidence="3 4">
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        <lineage>
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            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomyces</taxon>
        </lineage>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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    </dbReference>
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        <property type="gene ID" value="AA958_07880"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_07880"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1659"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR038721">
        <property type="entry name" value="IS701-like_DDE_dom"/>
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    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13546">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_5" evidence="2">
        <location>
            <begin position="22"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="438"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH82166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="485" mass="54656" checksum="CA4F58602ECDAA59" modified="2015-07-22" version="1">MSVVCRDVRREAFAEASRFRGEFYECLTARRDELFELTDALLCVDGPVTSPVDLTMVPEHRRGHGALYGALNRGGIDVERLRTLLAGLPLPRFESGRLVLAVDVSPWLRSDAPCSADRLFCHVYGRAKSASQFIPGWPYSFVAVLEPGATSWTSILDVVRLGPEDDATAVTAAQLRAVAERLISAGQWTPGDPDITIVMDAGYDVTRLAWVLRDLPVELVGRIRSDRVMRLPKPSPEEYSLAYPQGGRPPKHGKEFRFAKPETWPEAAITTITDTANYGKAEAQAWDRVHPRLTHRSAWLEHDGELPVVEGTLVRLKVEHLSKEREAPPVWLWSSKTGAAPTDVDLWWQVFLRRFDLEHTFRFGKQILGWTTPKVRAPEAADRWTWLVVVAHTQLRLARPLAADLRRPWEKPTKPERLTPARVRRGFRNIRAHLLCPARVPQPRGTGPGRPPGTKNRRPAPRYDVGKTVRRPETLKAIGRPGRSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2I1</accession>
    <name>A0A0F7N2I1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_01560</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0749 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014432.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_01560"/>
    <dbReference type="EnsemblBacteria" id="AKH81067">
        <property type="protein sequence ID" value="AKH81067"/>
        <property type="gene ID" value="AA958_01560"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_01560"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.343"/>
    <dbReference type="OrthoDB" id="1711743at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010273">
        <property type="entry name" value="DUF881"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37313">
        <property type="entry name" value="PTHR37313"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05949">
        <property type="entry name" value="DUF881"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="60"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="109"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH81067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="278" mass="30300" checksum="D52B52164C0AE6A0" modified="2015-07-22" version="1">MQRRPPAPQLPGPPAPPERTAPAERSAPPEPSSPPEPELGAGRRRLVDAVWPLRLTRSQLIVALLLFVLGLGLAIQVRSTGESSALRGARQEDLVRILDELDDRTQRLEDERERLEDQKAELENSSDQAEEARRQTEAKERQLGVLAGTVAAEGPGIEITVRGPEGAVEADMLLDTIQELRAAGAEAIQINGVRVVAGTHFADAGESDVEIDGRRVSQPYVFRVIGRAEDLEPALNIPGGVVQTMEEEQATVSIEPRDTVLVDALRREKRPDYARSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2S7</accession>
    <name>A0A0F7N2S7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycerol acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_02025</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014511.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_02025"/>
    <dbReference type="EnsemblBacteria" id="AKH81147">
        <property type="protein sequence ID" value="AKH81147"/>
        <property type="gene ID" value="AA958_02025"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_02025"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.437"/>
    <dbReference type="OrthoDB" id="1756450at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PlsC" evidence="2">
        <location>
            <begin position="38"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH81147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="245" mass="26695" checksum="DC4B58EEA06D6A1F" modified="2015-07-22" version="1">MADLVYPPVVGICKTAFKAMDLRIDLKGQEHVPRRGGAVLVSNHISYLDFVFCGYAARPAKRFVRFMTKESVFRHRVSGPLLRAMKHIPVDRAQGGQAFAHALRALRSGEVVGVFPEATISQSFTLKSFKSGAARLAQQAGVPLLPMAVWGTQRIWTKGRSRDFGRNHLPITLRLGAPVPTGDGVADAPAEGAHEDAEKLTERLKGRIQELLEAAQHAYPDRPRGPGDDWWQPAHLGGSAPVPGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N359</accession>
    <name>A0A0F7N359_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_02885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014655.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_02885"/>
    <dbReference type="EnsemblBacteria" id="AKH81292">
        <property type="protein sequence ID" value="AKH81292"/>
        <property type="gene ID" value="AA958_02885"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_02885"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.617"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="63" mass="6502" checksum="AA2DA76527DBEBDB" modified="2015-07-22" version="1">MTGAEDLLARRRGGAALAPLDPAARTPAGRVAVLACMDARLGVTEGPAGERPPGKFPDYQLMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N370</accession>
    <name>A0A0F7N370_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LacI family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_13600</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016425.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_13600"/>
    <dbReference type="EnsemblBacteria" id="AKH83095">
        <property type="protein sequence ID" value="AKH83095"/>
        <property type="gene ID" value="AA958_13600"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_13600"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2862"/>
    <dbReference type="OrthoDB" id="1796334at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="4"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH83095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="338" mass="36566" checksum="B0E5954DA8D60000" modified="2015-07-22" version="1">MAKVTRDDVARLAGTSTAVVSYVINNGPRPVAPATRERVLAAIKELGYRPDRVAQAMASRRTDLIGMIVPDARQPFFGEMAHAVEQAASERGKMVLVGNSDYLDDREVHYLRAFLGMRVSGLILVSQGPSAAAAAEIDAWDARVVLMHERRDQPDDLVVVTDDVGGARLATSHLLEHGHAYVACLGGVETTPTTGDPVTDHVEGWRIAMRAAGRSTEGRLFQSPYNRYDAYQVGLKLLSGPDRPPAIFCATDDQAIGLLRAARELRIDVPGELAVAAFDNVKEAGLTDPPLTTVASDRPAMARAAVDLVLDETPLATRRERLKQFPSHLVVRRSCGCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3L1</accession>
    <name>A0A0F7N3L1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_14635</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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            <begin position="1"/>
            <end position="33"/>
        </location>
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        <location>
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            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH83260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="160" mass="15749" checksum="CDCFB362B7DAEE19" modified="2015-07-22" version="1">MPGTHAASLPRLCRAVIALLAGLAIVVLAPVFACVDAGTPHHDGGGSLRGSTPALALAPVAYAEVTRAHAARHVEDHLDDHAGHADCGEPCCEPSAALPHAVVRDDPAGSAAHPAAAVPAPAPGALRDDGGARAAPPAAAVLPAARPGAALLRLVCVSRT</sequence>
</entry>
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    <accession>A0A0F7N3X1</accession>
    <name>A0A0F7N3X1_9ACTN</name>
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        <name evidence="2" type="ORF">AA958_07245</name>
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        <name type="scientific">Streptomyces sp. CNQ-509</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="17"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="103" mass="11659" checksum="68444383EA3C1F60" modified="2015-07-22" version="1">MTADDSFGRLDDDDYPAYTMGRAAEILGTTPGFLRALGEHRLITPLRSKGGHRRFSRYQLRIAARARELVDQGTPIEAACRIVILEDQLEEAQRINAERDRTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N433</accession>
    <name>A0A0F7N433_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chitinase</fullName>
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    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_07670</name>
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    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:cell wall macromolecule catabolic process"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Lysozyme-like_dom_sf"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
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        <location>
            <begin position="33"/>
            <end position="254"/>
        </location>
    </feature>
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        </location>
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    <feature type="active site" description="Proton donor" evidence="1">
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        </location>
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        <location>
            <begin position="126"/>
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        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="222"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH82129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="254" mass="26832" checksum="1FEE407C03AD4184" modified="2015-07-22" version="1">MLRKLGTKVKAMLAIGALAAALAVVVPVTASAGEGGTAGEGGADRAVAAEFMVSEAQFEQMFPGRNAFYTYQGLTDALSAYPAFANTGDETTRKREAAAFLANVSHETGGLVHVVEQNQDNYPHYCDASQPYGCPAGQAAYYGRGPIQLSWNFNYKAAGDALGIDLLNDPWQVERNAAVAWKTGIWYWMTQSGPGSMPAHDAIVGGHGFGETIRAINGSLECNGGNPGQVQSRIDKYTQFAQILGTTPGDNLSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N459</accession>
    <name>A0A0F7N459_9ACTN</name>
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    </gene>
    <organism evidence="4 5">
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        <lineage>
            <taxon>Bacteria</taxon>
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        </lineage>
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    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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    </dbReference>
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    </dbReference>
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        <property type="gene ID" value="AA958_07890"/>
    </dbReference>
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    <dbReference type="PATRIC" id="fig|444103.5.peg.1661"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="project" value="UniProt"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
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            <end position="68"/>
        </location>
    </feature>
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            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH82168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="207" mass="22193" checksum="52315D0F5FC5643C" modified="2015-07-22" version="1">MPRQVDHESRRRTIAEAVCRLADERGLEGVTLRDVAARAEVSMGAVQRCFRTKEEMLVFALGYVGERIGERVRARLVRSPAQSAGTALGHAAAEVSLLGDEHRAEARVWLAFVAQAAVSEALAGTLRANYAGLHEVFARLVAEARGGAGREESGDPAPEGAEPLDPEREARTLLALADGLTVHVLVGHLTPHEAHEVLHAHLAGLWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4K5</accession>
    <name>A0A0F7N4K5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_08855</name>
    </gene>
    <organism evidence="1 2">
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        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015665.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_08855"/>
    <dbReference type="EnsemblBacteria" id="AKH82318">
        <property type="protein sequence ID" value="AKH82318"/>
        <property type="gene ID" value="AA958_08855"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_08855"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1865"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH82318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="309" mass="32802" checksum="A74C202E219F4520" modified="2015-07-22" version="1">MAHSHHVRHTGTVAAPPIVVYGLLSDAPGWSRLFPAVVHAERDPAAGGEDVLRLWTTADGGVGDVRVRLTPDPDALTLGFRYEGPRPPAAGRSGTWRIRPAAGGCEVVLDQAYAAAGDAPERLARLRAAAEADAESGLESLKQAAEHADRIGDVLLTFADELEIAAAPAAVHDFLWRAGAWAELVPHVARAALTEVSPRAQFLELDTVLPDGSTHTTESVRVRPGPGRIVSKRLRLPALLAAHLTEWSFTETAGGVRAVHRHTAVLRPEAMPDFPGAGATLAEARAHVRKALGTASRETLRCARAAVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4K7</accession>
    <name>A0A0F7N4K7_9ACTN</name>
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        </submittedName>
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        <name evidence="3" type="ORF">AA958_05755</name>
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        <name type="scientific">Streptomyces sp. CNQ-509</name>
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        <lineage>
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        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="37"/>
            <end position="70"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH81787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="289" mass="32014" checksum="AFAA392A3E389901" modified="2015-07-22" version="1">MGAGGSEQARHQRKAGKRVKKEKEAPPPAWVAYGKLVKLHRQRAGMTQPQLADLVGYSVDTVAAIEQAKRPAKLAFTQGAERELDAQGTLMVLQEEVDRAKLPEFFRDVALLEEEALSRYGWDPLLVPGLLQTEDYARALFSAHCPPLAEDEIEQSVEARLARQRLLTRKKPVELCFVIGEAALRNPVGGKRVQREQLEALQKHADLPHVEIQVMSWACGFHPGLNGPMVVMETAEHEVVGYVESQGAGFVVSDADRVSSFTHRYGKMRSLALSPDESARFIDRLAGDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4M5</accession>
    <name>A0A0F7N4M5_9ACTN</name>
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        <recommendedName>
            <fullName evidence="1">Methyltransf_25 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_12735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="AA958_12735"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_12735"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2676"/>
    <dbReference type="OrthoDB" id="1865374at2"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="52"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="215" mass="22918" checksum="9E561506EEACB750" modified="2015-07-22" version="1">MARAGDHDRTRTSYDTVAETYLGTVGGELAHKPLDRALLAAVLEQAGDGAPVADLGCGPGHVTGWLAAHGARAVGIDLSPGMVALARREHPAAEFREGDLLRLPAADGEFGAAVALYSVIHLAPEELAPAFAEARRVLRPGGRLLVSFHVGTEVRHLDDWWGHPVDVDFRFLEPAAVAALLGAAGFEVEATLERAHYPQEPETTRAYVLARRPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4R6</accession>
    <name>A0A0F7N4R6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Molybdate ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AA958_17115</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="AKH83645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_17115"/>
    <dbReference type="EnsemblBacteria" id="AKH83645">
        <property type="protein sequence ID" value="AKH83645"/>
        <property type="gene ID" value="AA958_17115"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_17115"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3599"/>
    <dbReference type="OrthoDB" id="1915735at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015098">
        <property type="term" value="F:molybdate ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011867">
        <property type="entry name" value="ModB_ABC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006469">
        <property type="entry name" value="NifC_ABC_porter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01581">
        <property type="entry name" value="Mo_ABC_porter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02141">
        <property type="entry name" value="modB_ABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="94"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="223"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="94"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AKH83645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="305" mass="31849" checksum="61B7FE11C73EC045" modified="2015-07-22" version="1">MTLPSGADKGEAADTPAGGPAPLRRRRVRPRPASRTASRPRARPPGRGGAPLPLLVPALLGLAFLVLPLLALLLRAPWSSMPELLTSTEVWQALRLSLVCATAATALSLVIGVPLAWLLARVEFPGRGLVRALVTLPLVLPPVVGGVALLMALGRNGVVGRWLDDWFGVTLPFTTAGVVVAEAFVAMPFLVIAVEGTLRAADPRYEEAATTLGASRFTAFRRVTLPLVAPGIAAGAVLAWARALGEFGATITFAGNFPGRTQTMPLSVYLALQSDPEAAIALSLVLLAVSVAVLAGLRDRWMTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4T1</accession>
    <name>A0A0F7N4T1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA_pol3_delta domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_09400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015753.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_09400"/>
    <dbReference type="EnsemblBacteria" id="AKH82408">
        <property type="protein sequence ID" value="AKH82408"/>
        <property type="gene ID" value="AA958_09400"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_09400"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1984"/>
    <dbReference type="OrthoDB" id="1199768at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009360">
        <property type="term" value="C:DNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010372">
        <property type="entry name" value="DNA_pol3_delta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005790">
        <property type="entry name" value="DNA_polIII_delta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06144">
        <property type="entry name" value="DNA_pol3_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="SSF48019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01128">
        <property type="entry name" value="holA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_pol3_delta" evidence="2">
        <location>
            <begin position="28"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH82408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="337" mass="34790" checksum="D3A6E5F434E5E732" modified="2015-07-22" version="1">MAATTRNPRTSKGGSAGGDPLTPVTLAVGQEDLLVDRAVQEVVAAARAADPDTDVRELTHDALQPGTLAELTSPSLFAERKVVVVRGAQDLAADAVKDVKAYVAAPAPEITLVLAHAGGAKGKGLLDAARKAGAREVDCAKVTRPADRLAFVKAEFRAAGRTATPSACQALVDAIGSDLREMAGACAQLAADVEGTIDDAVVARYYTGRAETSGFEVADRAVEGRTAEALEALRWALGTGVAPVLLTSALAQGVRSIGRLASAPRGMRPADLARELGMPPWKVDRVRQQMRGWTADGVATALRAVAQADADVKGGSDDPGYALEKAVVTISTAARPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N510</accession>
    <name>A0A0F7N510_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_13605</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016426.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_13605"/>
    <dbReference type="EnsemblBacteria" id="AKH83096">
        <property type="protein sequence ID" value="AKH83096"/>
        <property type="gene ID" value="AA958_13605"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_13605"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2863"/>
    <dbReference type="OrthoDB" id="817710at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="124"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="1">
        <location>
            <begin position="124"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="223"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH83096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="249" mass="27219" checksum="5C77438611EDFAB9" modified="2015-07-22" version="1">MSSLLLLTNALQPSAEVLPALGLLLHNVRVAPAEGPALIDTPGADVILVDGRRDLPQVRSLCQLLRSTGPGCPLILVVTEGGLAAVTAEWGVDDVLLDTAGPAEVEARLRLALGRQQLPADESPTEIRNGDLTVDEATYSAKLKGRVLDLTFKEFELLKYLAQHPGRVFTRAQLLQEVWGYDYFGGTRTVDVHVRRLRAKLGPEHESLIGTVRNVGYRFVVPEKGEKKPENRAEKQEQKGAAQEARHRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5A8</accession>
    <name>A0A0F7N5A8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Endoglucanase</fullName>
            <ecNumber evidence="6">3.2.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AA958_10440</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the glycosyl hydrolase 9 (cellulase E) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.4" evidence="6"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015916.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_10440"/>
    <dbReference type="EnsemblBacteria" id="AKH82574">
        <property type="protein sequence ID" value="AKH82574"/>
        <property type="gene ID" value="AA958_10440"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_10440"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2199"/>
    <dbReference type="OrthoDB" id="1226595at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030247">
        <property type="term" value="F:polysaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02850">
        <property type="entry name" value="E_set_Cellulase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001919">
        <property type="entry name" value="CBD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008965">
        <property type="entry name" value="CBM2/CBM3_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012291">
        <property type="entry name" value="CBM2_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004197">
        <property type="entry name" value="Cellulase_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003305">
        <property type="entry name" value="CenC_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001701">
        <property type="entry name" value="Glyco_hydro_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033126">
        <property type="entry name" value="Glyco_hydro_9_Asp/Glu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00553">
        <property type="entry name" value="CBM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02018">
        <property type="entry name" value="CBM_4_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02927">
        <property type="entry name" value="CelD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00759">
        <property type="entry name" value="Glyco_hydro_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00637">
        <property type="entry name" value="CBD_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49384">
        <property type="entry name" value="SSF49384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51173">
        <property type="entry name" value="CBM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00698">
        <property type="entry name" value="GH9_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="3 5 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 5 6" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005117482" description="Endoglucanase" evidence="6">
        <location>
            <begin position="27"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="domain" description="CBM2" evidence="8">
        <location>
            <begin position="756"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="678"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="720"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="729"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH82574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="861" mass="89774" checksum="B41D341199035649" modified="2015-07-22" version="1">MRRHLPRALAAVLVAGALAAPGAAAADEGPELILNGGFDAGTAPWWFTPDSPGTVVDGRLCADVPAGTVNPWDAIIGQDALPITAGETYALRYTATATTPVTIRTNVQQAVEPWGQFFSSADQVTETATTFEHVFTATAADDAAQLAFQIGGSDAAFTFCLDDVSLRGGAEQPPYDPDTGSPVRVNQVGYLTEGPKNGTFVTEAAQPLTWTLNAADGTEKASGTTVPAGTDPTSLENVHTFAFGDFTEAGEGYTVTIDGETSEPFAIGDDIYGTLRTDALAYFYHNRSGIEIDADLVGEEYARPAGHVNVEPNQGDSDVPCQPGVCDYTLDAAGGWYDAGDHGKYVVNGGIAAAQVMSVYERTLTTDGADGEPIGDGKLAVPERGNGVPDVLDEARWQMEFLLSMQVPAGEELAGMAHHKLHDDQWTALPTLPHEDAQARELHPPSTAATLNLAATGAQCARLYADFDADFADRCLAAARTAYAAAEANPDRLADPNDGTGGGAYSDGEVSDEFYWAAAELYLSTGEDAYLQDVLDSPLHGDAEAVFPADGMSWAATAGLGALDLATVDSGLTDAQLAAVRGMVTDAADGYAADAANAAYGVPYAPAGGRYVWGSNSQVLNNMVVLATAHGLTGEAGYRDAVLTGLDYLLGRNPLNQSYVTGHGERDSKNQHHRFWANQLDPSLPNPPAGALAGGPDSQLEDPVAQRELAGCPPAMCYIDHIESYSTNEVTINWNAPLAWIAGYADDLGSGGGDPGPGPGEECSAAYSVPNQWPGGFTGTVTISCDGAALDGWTAQWDFPDGQRLQNAWNAVCSQTGTTVTCRNTPYNGRVPDGGSVSFGFNAGWSGSNGTPREVKLGGGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5G3</accession>
    <name>A0A0F7N5G3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_14950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH83301">
        <property type="protein sequence ID" value="AKH83301"/>
        <property type="gene ID" value="AA958_14950"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_14950"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3151"/>
    <dbReference type="OrthoDB" id="1995337at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH83301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="63" mass="6977" checksum="ADC5E55ABF1B68B1" modified="2015-07-22" version="1">MPDITWEQPFCQDSGNCFRIGTDAEGNAHIAVAGREEHRVTDSVEALRTLIRDIKAGKADHLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5G7</accession>
    <name>A0A0F7N5G7_9ACTN</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_10860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
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    <dbReference type="EnsemblBacteria" id="AKH82644">
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        <property type="gene ID" value="AA958_10860"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_10860"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2284"/>
    <dbReference type="OrthoDB" id="1735354at2"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="DUF6529"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="195" mass="21049" checksum="3C9231F4AD47AB37" modified="2015-07-22" version="1">MPSKTGRHRAPRRPTRAHRVFFALGALLPVATGVAIWLVGQHHTPEYATSLFGEEGEGAVTLKARLGTALFGLAVIQVLLALLMYGRRGGLTAAPRRVRLTHRVIGWGAFVLSVPIAYHCVRTYGVETSSTRVYMHSVAGCALYGAFVAKVLVVHSRHLPGWLLPAAGSTLFAAIGVLWYSAPLWVLNEYAVPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N617</accession>
    <name>A0A0F7N617_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_12180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH82868">
        <property type="protein sequence ID" value="AKH82868"/>
        <property type="gene ID" value="AA958_12180"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_12180"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2562"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
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        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="281"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH82868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="302" mass="31879" checksum="3330D1F6346DCD12" modified="2015-07-22" version="1">MSRRHGLEGRTVVVTGAARGVGALLARRLAARGARLALVGLEPGELKKVADSLPGEAAHWYADVTDHDAMAGAAAEVEEHFGSVDVVVANAGVATGGPFLDSDARSFDRVIEVNLLGSVATARAFLPALVRARGYHLQIASLAAVTPAPMMAAYCASKSGVEAFAHCLRGEVGHQGVDVGVAYLSWTDTDMVRGADEDEVLRDMRARLPWPSNKTYPLAPAVERLVAGIERRSPHVYGQWWLRGMQSVRGALPSLVTGPLGRREMGKLAPRLAATRGARGGLVGAGGAADERTRALREAPER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N666</accession>
    <name>A0A0F7N666_9ACTN</name>
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        <submittedName>
            <fullName evidence="2">GNAT family acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_08935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
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        <lineage>
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            <taxon>Actinobacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH82332">
        <property type="protein sequence ID" value="AKH82332"/>
        <property type="gene ID" value="AA958_08935"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_08935"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1882"/>
    <dbReference type="OrthoDB" id="1777515at2"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="F:glucosamine 6-phosphate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13508">
        <property type="entry name" value="Acetyltransf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="150" mass="15677" checksum="9AB22F16C1E5A55C" modified="2015-07-22" version="1">MAIRTARVDVAEIFALRHSVLLPGRPPAEAEFAEDGAPGAFHLAAYDERGALAACVSFCPELLPGDGTPAYRFRGMASAPAVRGRGYGVAVLAAGLAEAAARDAHLVWCNARTSAAGFYLKHGFEVRGAEFDIEGVGPHVVMTRKLTPGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N697</accession>
    <name>A0A0F7N697_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">AA958_12185</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016204.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_12185"/>
    <dbReference type="EnsemblBacteria" id="AKH82869">
        <property type="protein sequence ID" value="AKH82869"/>
        <property type="gene ID" value="AA958_12185"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_12185"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2563"/>
    <dbReference type="OrthoDB" id="1196738at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="44"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH82869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="349" mass="36020" checksum="6E54FFF8A03B9793" modified="2015-07-22" version="1">MTRLMHVTTGPYAPPVPRRELTAVSADGTRLYVEEHGPEDAPAVVLAHGWCCSTAFWAPVVRQLAPEYRVVVYDQRGHGRSPAGGYGSYHTATLADDLGAVLDAALVPGEKAVIGGHSMGGMTLMAAAGRPYLRERAAAVLLCSTGSSGLVPESRVIPLRARALRSAIQRALLVSRLPMGPVTPLSKKVLAPAILGRGATPAQIEASVRIVFATPRRARGAWGRVLAELDLDAEVARMPVPAAVVHGGADRLTPVKLARKIDELLPERAGFTELPGLGHMTPVEAPYAVAEVLRGLVRDHLAGAPEEAQAEGGAVAAGDAVSGTAGDAADGKTAGPAAAAAVEKEEAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6B4</accession>
    <name>A0A0F7N6B4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Potassium transporter</fullName>
        </submittedName>
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        <name evidence="6" type="ORF">AA958_12365</name>
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        <name type="scientific">Streptomyces sp. CNQ-509</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AKH82894">
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        <property type="gene ID" value="AA958_12365"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_12365"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2598"/>
    <dbReference type="OrthoDB" id="1194802at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:monovalent cation:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR006037">
        <property type="entry name" value="RCK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036721">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR32507:SF7">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02080">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
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        <location>
            <begin position="92"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
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        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="297"/>
            <end position="320"/>
        </location>
    </feature>
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        <location>
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            <end position="352"/>
        </location>
    </feature>
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        <location>
            <begin position="364"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="RCK C-terminal" evidence="5">
        <location>
            <begin position="400"/>
            <end position="481"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="500" mass="52706" checksum="6EB069E63BE55A53" modified="2015-07-22" version="1">MSVEELNKLALVAALVLLVAVAAVRLASRSGLPSLLLYMGIGVLVGEDGLFGYDFDDAELTQVFGYAALALILAEGGLGTKWSEIKPALPTAAVLSTAGVAVSVGVTATGAHYLIGLEWKQALIMGAVVSSTDAAAVFSVLRRVPLPKRITGVMEAESGFNDAPVVILVVAFSTSGHLESWYVLLGEILLELAIGAALGLAIGWLGSMALRHVALPASGLYPIAVMALAIVAYAVGALAHGSGFLAVYLAAMVLGNAKLPHWSATRGFADGVGWLAQIGMFVLLGLLVTPHELGDDIVPAVIVGLVLTMVARPASVIVSLLPFRIPWREQALMSWAGLRGAVPIVLATIPMVNEVADSGRVFNIVFVLVIVYTMVQGPTLPLVARWLRLGDGDEAYDLGIESAPLERVRGHLLSLSVPERSRMHGVEVGELRLPPGAAVTLVVRDGTSFVPAPTDILRRGDELLVVTTDEVRDATEQRLRDVGRGGKLARWLSADERRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6J9</accession>
    <name>A0A0F7N6J9_9ACTN</name>
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            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="2" type="ORF">AA958_12870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH82969">
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        <property type="gene ID" value="AA958_12870"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_12870"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2707"/>
    <dbReference type="OrthoDB" id="2002534at2"/>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="143"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="305" mass="32716" checksum="8D360B47D9898ECD" modified="2015-07-22" version="1">MRRRPLAPPSPARLTVRPYAPADESAVLRLVNADRLPGQPPATPAMLADALAGRSRADADWWAELDPPVTAVAETPGGGVQGVVSYALRPPDDTGLILWAHCREQAPVARALVDHAVAALAPRAVDAFHLTSALTLGLECLPVRHRPDTRAALVRAGFADQRRWRYLRRGLPAAELPRVPGLLVGPGPDGDPRKRQLTVRDERGEAVVAEALVGAHGGYGALWWIGVEEHARGRGLARRLLGSALATLTDDLRATQVILLLDDDDTDATAQDIRDRTAAAALYGRAGFTEIDLLHAFTRPRAEGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6L2</accession>
    <name>A0A0F7N6L2_9ACTN</name>
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        <submittedName>
            <fullName evidence="7">RNA polymerase sigma70</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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        </lineage>
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    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_12960"/>
    <dbReference type="EnsemblBacteria" id="AKH82984">
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        <property type="gene ID" value="AA958_12960"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_12960"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2728"/>
    <dbReference type="OrthoDB" id="1992113at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
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        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
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        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="5">
        <location>
            <begin position="38"/>
            <end position="102"/>
        </location>
    </feature>
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        <location>
            <begin position="134"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH82984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="191" mass="21317" checksum="801A6BDEDDE3B810" modified="2015-07-22" version="1">MVQGTGPHGTGQGAVPPRWNRKMQQRLARGEAAALSELYDRFAPLVYGLAQRVLENEEEANGVLAEVFSYVWQHPDAYDPKRGQLRSFLAGLAHKHAVRRLRWAVIQAGAAGEIEDSEERIRAVSAAARADYIVTSMPEPQRAALELAYFKRRDYRQTAEELGVSPDEARRRLRLGLQMLATAHTEAGRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6M3</accession>
    <name>A0A0F7N6M3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pilus assembly protein TadG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_13015</name>
    </gene>
    <organism evidence="2 3">
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        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_13015"/>
    <dbReference type="EnsemblBacteria" id="AKH82994">
        <property type="protein sequence ID" value="AKH82994"/>
        <property type="gene ID" value="AA958_13015"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_13015"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2739"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012495">
        <property type="entry name" value="TadE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07811">
        <property type="entry name" value="TadE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="125" mass="13596" checksum="AC37AB6B51DDB5F5" modified="2015-07-22" version="1">MSAVEFVLLTPVLYFMIFATVQFGLYFFADHVAQATAQHGAREARRTAESNPGGWQGLAQQAARERLNTVGPKLLTSPDIRVYEAADDRVGVAVEGGVVNVFPFIDLTARAESEGPIERFVPDLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6Z2</accession>
    <name>A0A0F7N6Z2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Transcriptional regulator WhiB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">whiB</name>
        <name evidence="14" type="ORF">AA958_21495</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="11">Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="11">The Fe-S cluster can be nitrosylated by nitric oxide (NO).</text>
    </comment>
    <comment type="PTM">
        <text evidence="11">Upon Fe-S cluster removal intramolecular disulfide bonds are formed.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the WhiB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017608.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_21495"/>
    <dbReference type="EnsemblBacteria" id="AKH84345">
        <property type="protein sequence ID" value="AKH84345"/>
        <property type="gene ID" value="AA958_21495"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_21495"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4525"/>
    <dbReference type="OrthoDB" id="1975204at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035731">
        <property type="term" value="F:dinitrosyl-iron complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01479">
        <property type="entry name" value="WhiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034768">
        <property type="entry name" value="4FE4S_WBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003482">
        <property type="entry name" value="Whib"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38839">
        <property type="entry name" value="PTHR38839"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02467">
        <property type="entry name" value="Whib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51674">
        <property type="entry name" value="4FE4S_WBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 11" id="KW-0408">Iron</keyword>
    <keyword evidence="6 11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 11" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="4Fe-4S Wbl-type" evidence="13">
        <location>
            <begin position="22"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="86"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="98"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AKH84345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="123" mass="13208" checksum="C760487E57D0904A" modified="2015-07-22" version="1">MADFSRLPGPNADLWDWQLIAACRGVDSSLFFHPEGERGAARSAREASAKEVCMRCPVRAECAAHALAVREPYGVWGGLTEDEREELLGRARHRTPPPGSASPAPAAAPAPEEAPTRTPTPHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N770</accession>
    <name>A0A0F7N770_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_14485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016554.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_14485"/>
    <dbReference type="EnsemblBacteria" id="AKH83239">
        <property type="protein sequence ID" value="AKH83239"/>
        <property type="gene ID" value="AA958_14485"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_14485"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3049"/>
    <dbReference type="OrthoDB" id="1956412at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd02199">
        <property type="entry name" value="YjgF_YER057c_UK114_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013813">
        <property type="entry name" value="Endoribo_LPSP/chorism_mut-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14588">
        <property type="entry name" value="YjgF_endoribonc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="SSF55298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YjgF_endoribonc" evidence="1">
        <location>
            <begin position="6"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="155" mass="15634" checksum="455DF7AAE58F8E7B" modified="2015-07-22" version="1">MAGRVEGKLAELGLSLPEVVPPLASYVPAVRSGPYVFTAGQLPMVDGTLPLTGKVGAEVTPEEARELAARCALNGLAAIKSVAGDLDRVVRVVKVVGFVASAPDFTAQPGVVNGASELLGQALGEAGVHARSAVGVAVLPLDAPVEIEFQAELAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N792</accession>
    <name>A0A0F7N792_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_22220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017721.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH84460">
        <property type="protein sequence ID" value="AKH84460"/>
        <property type="gene ID" value="AA958_22220"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_22220"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4680"/>
    <dbReference type="OrthoDB" id="2093632at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004658">
        <property type="term" value="F:propionyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032716">
        <property type="entry name" value="ACC_epsilon"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13822">
        <property type="entry name" value="ACC_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH84460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="70" mass="7394" checksum="88DFC95B4DE97750" modified="2015-07-22" version="1">MSDEIKVVRGNPTAEELAAALAVVQARAASSVPGGRGGPAGEWADPARRVLARRTPQPGPKAWRTTYWPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7E4</accession>
    <name>A0A0F7N7E4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_15060</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016633.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_15060"/>
    <dbReference type="EnsemblBacteria" id="AKH83318">
        <property type="protein sequence ID" value="AKH83318"/>
        <property type="gene ID" value="AA958_15060"/>
    </dbReference>
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    <dbReference type="PATRIC" id="fig|444103.5.peg.3173"/>
    <dbReference type="OrthoDB" id="1283908at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="161"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="254"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="293"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="321"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH83318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="345" mass="35251" checksum="94259653C391C231" modified="2015-07-22" version="1">MTRARALPFPALLVLLLGLLLLSATAAVALGSVRVPAGQVWGILLHRLHPALADPGWSPVRETIVWDVRLPRVLLAGAVGAGLAVCGMALQALVRNPLADPMLLGISSGATVGAVLVVVLNVTVLGLFTLPLAAFAGALAALVAVYFLALGADGRMTSLRLVLAGVATAEVLSAVVGFLIVTSGDPHKTQAALRWMLGGLAGSTWRLIWIPLAVVVLGTVALLAVARPLNLLLAGEEAAAALGLDVHRFRSAMFALVAVMVGAAVAVSGAIGFVGLILPHVVRLLTGADHRRALPAAALLGAAFLIAADLAARTLISPEEVPVGVLTALAGGPFFLWLMRRGAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7I7</accession>
    <name>A0A0F7N7I7_9ACTN</name>
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        <recommendedName>
            <fullName evidence="2">HTH luxR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_15190</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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    <dbReference type="EnsemblBacteria" id="AKH83338">
        <property type="protein sequence ID" value="AKH83338"/>
        <property type="gene ID" value="AA958_15190"/>
    </dbReference>
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    <dbReference type="PATRIC" id="fig|444103.5.peg.3200"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="LuxR_C_like"/>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="262"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH83338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="329" mass="35248" checksum="9EAE5B8DA5C594B6" modified="2015-07-22" version="1">MFEPFGVLASDEALYRLLLRHPPLDTARLAAAAGRTEAETAPAVERLAELGLVTLLPGAPVRLVATRPDAAVDQLTVRWQDQVAVARTAATALLADLPVDRRHRPEDQVEILFGRGSVAARFDRLQRSVRRELLVLDRPPYAQEPAEPNRAELEILARGARVRGLYAPEALEVPGAFDVFEAVVAAGEQARVHTDVPLKLAVADASTAILPFSREAHEMVDSAFVIHEGALLDALVQLFELLWAAAVPVPAGPGTAAGAAPNERAGDAESDRQLLTLLAAGLKDEAVARRLGVSARTLNRRVSALMLRLGARTRFQAGLQAARNGALDL</sequence>
</entry>
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    <accession>A0A0F7N7W6</accession>
    <name>A0A0F7N7W6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chemical-damaging agent resistance protein C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_16375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_16375"/>
    <dbReference type="EnsemblBacteria" id="AKH83523">
        <property type="protein sequence ID" value="AKH83523"/>
        <property type="gene ID" value="AA958_16375"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_16375"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3447"/>
    <dbReference type="OrthoDB" id="1437267at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd06974">
        <property type="entry name" value="TerD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003325">
        <property type="entry name" value="TerD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02342">
        <property type="entry name" value="TerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TerD" evidence="1">
        <location>
            <begin position="1"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="191" mass="20379" checksum="89BDB4A691AD0720" modified="2015-07-22" version="1">MGVSLAKGGNVSLTKEAPGLTAVVVGLGWDVRTTTGSDFDLDASALLLGADGKVLSDQHFIFFNNLKSPDGSVEHTGDNLTGEGEGDDEQVKVNLAGVPAEIEKISFPVSIYEAESRQQSFGQVRNAFIRVVNQADNNEIARYDLSEDASTETAMVFGELYRNGAEWKFRAVGQGYASGLRGIAQDFGVNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7Y9</accession>
    <name>A0A0F7N7Y9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SLT_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_12435</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_12435"/>
    <dbReference type="EnsemblBacteria" id="AKH82907">
        <property type="protein sequence ID" value="AKH82907"/>
        <property type="gene ID" value="AA958_12435"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_12435"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2613"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043426">
        <property type="entry name" value="MltB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031304">
        <property type="entry name" value="SLT_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30163">
        <property type="entry name" value="PTHR30163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13406">
        <property type="entry name" value="SLT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519224" description="SLT_2 domain-containing protein" evidence="2">
        <location>
            <begin position="29"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="SLT_2" evidence="3">
        <location>
            <begin position="177"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH82907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="429" mass="41298" checksum="AC7209C7D9AD7C07" modified="2015-07-22" version="1">MASLSRMRHSVATAALAAAAMVALTASQAPGDEAGRAAGGGAEDRLDTAPVLPPGTPGDGQYHTEIPPLQGMDPVVSTQPTPPAVIEQQSGVPATVLDAYRKAERRIAVSDPGCGLPWELLAAIGKVESGHARGGAVDADGTTLTPILGPVLDGNGFAHISDTDGGRYDGDTGYDRAVGPMQFIPSTWAGWAADGNGDGRSDPDNVYDATLAAGHYLCAGGRDLTAAADLDRAILSYNYSRDYLTTVLAWLGFYRSGVHAVPDGAGVLPASSGAGNPRSVPEKGSRTPPGEPDGPGGIVVGPRPSPPDGGSGGTGGSGGSGGTGGSGGTGDSGGSGDPGGTGDPGGDPGGGDPGPSPSDPGESGGSGDPGGSGDPGGDPGGGTGDPGDPDPGGSCSADPGESPSPSPGEDPGASPCPDDSASPDPSGTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N846</accession>
    <name>A0A0F7N846_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_16770</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016893.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_16770"/>
    <dbReference type="EnsemblBacteria" id="AKH83589">
        <property type="protein sequence ID" value="AKH83589"/>
        <property type="gene ID" value="AA958_16770"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_16770"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3528"/>
    <dbReference type="OrthoDB" id="721431at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triglyceride lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005152">
        <property type="entry name" value="Lipase_secreted"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853">
        <property type="entry name" value="PTHR34853"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03583">
        <property type="entry name" value="LIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029171">
        <property type="entry name" value="Esterase_LipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519345" evidence="2">
        <location>
            <begin position="35"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH83589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="408" mass="42230" checksum="E55ECE9DBBD2C8B0" modified="2015-07-22" version="1">MHGRTLRRAFGTLAGTTAAAVAATVALPLTTASAAERPPFYEPPATLPAADGDVIRAEPSVYYLDPLKTLKVDANVQRVMYRSTDGQGAPIAVTGTVITPKSAWSGPGERPVIGYAAGTQGLGDQCAPSRQLANGTEYEGLFVKGLLARGYGVAMTDYEGLGTPGLHTYMNRAVQGHAVLDSVRAAQRLPAAGLPDDGPVAVYGYSQGGGAAASAAELARSYAPDLDVRGVAAGAVPADLAAVGRNLDGSLYAAFLGFAVAGLAEGSDVDLGPYLNDRGRQVMAEAAETCTAEAVLRYPFLQSKTLTADGRPITDHMDASPWREVVAEQRIGARKPEVPVFVSHSMLDDVIPYGVGKKLVAEWCAKGATVDFSTNVAPTHVGGAVASYPAAYGWLEGRLAGKPAPDNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N896</accession>
    <name>A0A0F7N896_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_24110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018037.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH84785">
        <property type="protein sequence ID" value="AKH84785"/>
        <property type="gene ID" value="AA958_24110"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_24110"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5081"/>
    <dbReference type="OrthoDB" id="1387978at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="46"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="298" mass="33422" checksum="E2A41A8683772EC1" modified="2015-07-22" version="1">MPELPFTRRRALGTAAAALAPTVAGFTEARADSRASGDGEDELHVMSFNLRYASATPPNSWPERRPVMRALLRAEEPHLVGTQEGLYPQLLDIAADLGRHHAWIGTGRKGGSKDEFMAVFYDIRRLAPVAFDHYWLSDEPYLIGSNTWGNAVLRMVTWIRFRDLVTGGEFYHVNTHLDHVNQQARELSAALITSRFAEFDASLPRVVTGDFNVPAHRNPVYDAMLVGGGLVDTWDAAERRSDAYATFHGYRPLVPDGDRIDWILVTPGVRTRYAKINTYERGGQFPSDHLPVQAFLRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8H2</accession>
    <name>A0A0F7N8H2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dihydropteroate synthase</fullName>
            <shortName evidence="1">DHPS</shortName>
            <ecNumber evidence="1">2.5.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Dihydropteroate pyrophosphorylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_18105</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DHPS family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.15" evidence="1"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017103.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_18105"/>
    <dbReference type="EnsemblBacteria" id="AKH83803">
        <property type="protein sequence ID" value="AKH83803"/>
        <property type="gene ID" value="AA958_18105"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_18105"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3807"/>
    <dbReference type="OrthoDB" id="1275854at2"/>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00156"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004156">
        <property type="term" value="F:dihydropteroate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00739">
        <property type="entry name" value="DHPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045031">
        <property type="entry name" value="DHP_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006390">
        <property type="entry name" value="DHP_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000489">
        <property type="entry name" value="Pterin-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20941">
        <property type="entry name" value="PTHR20941"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00809">
        <property type="entry name" value="Pterin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="SSF51717"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01496">
        <property type="entry name" value="DHPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00792">
        <property type="entry name" value="DHPS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00793">
        <property type="entry name" value="DHPS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50972">
        <property type="entry name" value="PTERIN_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pterin-binding" evidence="2">
        <location>
            <begin position="18"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU361205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH83803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="285" mass="29624" checksum="9D59529AEE0F3931" modified="2015-07-22" version="1">MTDARRGQVAGLPDFGRCAVMGVVNVTPDSFSDGGLWFDSAAAIKHGIDLVATGADIVDVGGESTRPGAPRVDEAEELRRVLPVVRGLAAEGVLVSVDTMRATVAEQAVAAGARLVNDVSGGQADPAMVPAVAATGVPFVVMHWRGQSIDMNNRAVYEDTVTEVVDELRRSLDRAVAGGIDVERIIADPGLGFAKAAPHDLVLLNSLARLRAELGRPLLVAASRKRFLGRILAGPDGSPPPARERDAATAAVSAIVAREGAWAVRVHEVRPTADAVRVASALEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8K2</accession>
    <name>A0A0F7N8K2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Multidrug ABC transporter ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_17915</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017076.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_17915"/>
    <dbReference type="EnsemblBacteria" id="AKH83774">
        <property type="protein sequence ID" value="AKH83774"/>
        <property type="gene ID" value="AA958_17915"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_17915"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3773"/>
    <dbReference type="OrthoDB" id="1926714at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="9"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH83774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="267" mass="28422" checksum="E21FEE1FD844D9FC" modified="2015-07-22" version="1">MVNIGPGAVHARGLSVVRGGATVLHDLGFDVPRGQVTGLLGPSGCGKTTLMRAIVGTQARVTGTLDVLGAPAGAARLRHRIGYVTQEPSVYRDLTARQNLDYFAAILEPGTSRAERRTQVARALADVDLTGEGDRLAGRLSGGQLARVSLAVALLGRPELLVLDEPTVGLDPVLRRDLWALFHEIAAERGATLLVSSHVMDEAERCQRLMLMRAGRILADDTPDGLRERVGSETVEEAFLRLVAAAGQRERRREGTDGDGDRGDGAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8N9</accession>
    <name>A0A0F7N8N9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nicotinate-nucleotide diphosphorylase (carboxylating)</fullName>
            <ecNumber evidence="4">2.4.2.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Quinolinate phosphoribosyltransferase [decarboxylating]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AA958_18230</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the catabolism of quinolinic acid (QA).</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from quinolinate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NadC/ModD family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.19" evidence="4"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017124.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_18230"/>
    <dbReference type="EnsemblBacteria" id="AKH83824">
        <property type="protein sequence ID" value="AKH83824"/>
        <property type="gene ID" value="AA958_18230"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_18230"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3833"/>
    <dbReference type="OrthoDB" id="1718114at2"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00331"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004514">
        <property type="term" value="F:nicotinate-nucleotide diphosphorylase (carboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01572">
        <property type="entry name" value="QPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004393">
        <property type="entry name" value="NadC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027277">
        <property type="entry name" value="NadC/ModD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037128">
        <property type="entry name" value="Quinolinate_PRibosylTase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002638">
        <property type="entry name" value="Quinolinate_PRibosylTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022412">
        <property type="entry name" value="Quinolinate_PRibosylTrfase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32179">
        <property type="entry name" value="PTHR32179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01729">
        <property type="entry name" value="QRPTase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02749">
        <property type="entry name" value="QRPTase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="SSF51690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00078">
        <property type="entry name" value="nadC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="QRPTase_N" evidence="10">
        <location>
            <begin position="78"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="QRPTase_C" evidence="9">
        <location>
            <begin position="167"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AKH83824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="338" mass="35102" checksum="FECA044779F008F1" modified="2015-07-22" version="1">MELTLLPLGGPDTGAGGCGDACGCGAGDGAADGAYGHDPLECGLDPGLAQLLVDAGLDPVYVEDVAHLAVEEDLDHGVDVTTVATVPEDAVATGDFTAREAGVVAGLRVTEAVLSVVCTDDMEVERHAEDGDLVAPGQRLLTVRTRTRDLLTAERSALNLLCRMSGIATSTRTWADALKGTAAKVRDTRKTTPGLRALEKYAVRCGGGVNHRMSLSDAALVKDNHVVAAGGLAEAFRLVRAEFPDLDVEVEADTLHQVREAVDAGADLILLDNFTPVETEEAVALVAGRARLESSGRLTLDNARAYAETGVDYLAVGALTHSTPILDIGLDLREGGDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8Q6</accession>
    <name>A0A0F7N8Q6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_13725</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016446.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_13725"/>
    <dbReference type="EnsemblBacteria" id="AKH83117">
        <property type="protein sequence ID" value="AKH83117"/>
        <property type="gene ID" value="AA958_13725"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_13725"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2889"/>
    <dbReference type="OrthoDB" id="1562270at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH83117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="241" mass="25646" checksum="C4D06D17EE1895FC" modified="2015-07-22" version="1">MNATPLAAALDSAKCVFFDFDGPICRLFSAHPAGLIAGQLLDLLDHWAPRLLGPGMYRPNDPLGILSAALQVAPDHEVIPTAEQLLTQEEQKAARHATSTPDAHALIEELDGQGRALAITSNNSAAAIRVYLDRHGLAPCFSPHVHGRRADPIRLKPDPDCLWRALESTGAMPGECLMIGDSPSDWKAAETAGVNFVGYARAPHKAEALEQAGVRLIVHSMKEILDAISGAAPAAVRPPDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8X5</accession>
    <name>A0A0F7N8X5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GH18 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_25340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_25340"/>
    <dbReference type="EnsemblBacteria" id="AKH84985">
        <property type="protein sequence ID" value="AKH84985"/>
        <property type="gene ID" value="AA958_25340"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_25340"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5340"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH18" evidence="1">
        <location>
            <begin position="1"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="174" mass="19410" checksum="E1A64577DD502928" modified="2015-07-22" version="1">MLTMAPETFFVQMGYQFYGTGQWGGQDPRCGAYLPVIHALRDSLTLLHVQDYNSGPIMGLDNQYHTMGGADFHIAMTDMLLTGFPVAGNAERFFPALRPDQVAIGMPASTQAGNGHVPTAEVNKTLDCLTKGSNCGSYKTHGTWPGMRGLMTWSINWDRYNNWEFSRNFDAYWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N919</accession>
    <name>A0A0F7N919_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptidase A24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_22575</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peptidase A24 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017779.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_22575"/>
    <dbReference type="EnsemblBacteria" id="AKH84521">
        <property type="protein sequence ID" value="AKH84521"/>
        <property type="gene ID" value="AA958_22575"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_22575"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4750"/>
    <dbReference type="OrthoDB" id="2046608at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014032">
        <property type="entry name" value="Peptidase_A24A_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000045">
        <property type="entry name" value="Prepilin_IV_endopep_pep"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01478">
        <property type="entry name" value="Peptidase_A24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00864">
        <property type="entry name" value="PREPILNPTASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="145"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="193"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="218"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_A24" evidence="4">
        <location>
            <begin position="96"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH84521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="242" mass="24355" checksum="D5A290702E23BD17" modified="2015-07-22" version="1">MLAVLLVVLAAGYGAAAGALLPRAAYRLSVAADEPWRDRCPQDHPLPGWAGPATCKECGGSPYGLRVRLPATATAAACAALAAATGPEPELAVWLLLAPFGVLLFAVDRAVRRLPDVLTLPLAGAAVVLLGGAALVGGAGSWTRALLGGLALGAIYFLLFFLNPAGMGFGDVKLALVLGVALGWYGWDVLFTGSFAGLLLGAGYAITMLAARRVGRKTGIAFGPFMIVGAFAGLVAGGLAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N978</accession>
    <name>A0A0F7N978_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosome maturation factor RimM</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rimM</name>
        <name evidence="6" type="ORF">AA958_25930</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Binds ribosomal protein S19.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="2">The PRC barrel domain binds ribosomal protein S19.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RimM family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018331.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_25930"/>
    <dbReference type="EnsemblBacteria" id="AKH85090">
        <property type="protein sequence ID" value="AKH85090"/>
        <property type="gene ID" value="AA958_25930"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_25930"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5460"/>
    <dbReference type="OrthoDB" id="1497415at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00014">
        <property type="entry name" value="Ribosome_mat_RimM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011961">
        <property type="entry name" value="16S_RimM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027275">
        <property type="entry name" value="PRC-brl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011033">
        <property type="entry name" value="PRC_barrel-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002676">
        <property type="entry name" value="RimM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036976">
        <property type="entry name" value="RimM_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05239">
        <property type="entry name" value="PRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01782">
        <property type="entry name" value="RimM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50346">
        <property type="entry name" value="SSF50346"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02273">
        <property type="entry name" value="16S_RimM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1 2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="RimM" evidence="4">
        <location>
            <begin position="5"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="PRC" evidence="5">
        <location>
            <begin position="94"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH85090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="189" mass="19920" checksum="2F7D1D82AF96BA4B" modified="2015-07-22" version="1">MQLVVARIGRAHGIKGEVTVEVRTDEPERRLAPGAVLTTDPAAAGPLTIATGRVHSGRLLLRFEGVTDRTAAEALRNTLLVADVDPEATPEDPEEFYDHQLADLDVVLRDGTPVGRVAEVAHLPYQDLLVVARPDGGEALIPFVSEIVPEIDLDAQRVVVQPPPGLLDVAVSGDRDGAPEGGRGGEGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9A0</accession>
    <name>A0A0F7N9A0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_26050</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018351.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_26050"/>
    <dbReference type="EnsemblBacteria" id="AKH85110">
        <property type="protein sequence ID" value="AKH85110"/>
        <property type="gene ID" value="AA958_26050"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_26050"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5485"/>
    <dbReference type="OrthoDB" id="1181903at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042953">
        <property type="term" value="P:lipoprotein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015854">
        <property type="entry name" value="ABC_transpr_LolD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24220:SF654">
        <property type="entry name" value="PTHR24220:SF654"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH85110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="223" mass="23224" checksum="90824B91E49DA3B3" modified="2015-07-22" version="1">MIELTNVTKTYPGGVTALAGVSLRVAAGELVAATGPSGSGKSTMLHVLGTLESPTSGEVRIAGYDVGALSDAGLSALRAHRIGFVFQQFHLAGGTSALDNVADGLLYTGLRPAERRRRAAGVLHRVGLAHRMEHRPHELSGGERQRVAVARAVAGDPPLLLADEPTGALDTASGAGVVELLRELNAAGTTVVVITHERELAASLPRQVRLRDGRLEQEGARAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9L4</accession>
    <name>A0A0F7N9L4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_26750</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018472.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_26750"/>
    <dbReference type="EnsemblBacteria" id="AKH85235">
        <property type="protein sequence ID" value="AKH85235"/>
        <property type="gene ID" value="AA958_26750"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_26750"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5628"/>
    <dbReference type="OrthoDB" id="1846332at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045830">
        <property type="entry name" value="AraR_wHTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19368">
        <property type="entry name" value="AraR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="4">
        <location>
            <begin position="11"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH85235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="251" mass="27115" checksum="6A59CCFDAB2F91B2" modified="2015-07-22" version="1">MPPYEPTAYPPFAVTVDLVVLTVRRHALSALIVRRGEAPFQGRWALPGGFVREEEDLTEAAARELAEETGLHAHGPVEEDTPAHAAHLEQLATYGDPKRDPRMRVVSVAHLVLAPDLPAPRPGGDVGGARWAPVATLVGPADEDGEQPPLAFDHRRILADGVERARSKIEYSSLATAFCPPEFTVGELRRVYEAVWGVALDPRNFHRKVTGTPGFLLPTGGTTTRQGGRPAQLFQAGGATILNPPMLRPEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9Q6</accession>
    <name>A0A0F7N9Q6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RNA methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_27015</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018521.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_27015"/>
    <dbReference type="EnsemblBacteria" id="AKH85285">
        <property type="protein sequence ID" value="AKH85285"/>
        <property type="gene ID" value="AA958_27015"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_27015"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5684"/>
    <dbReference type="OrthoDB" id="1421660at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030391">
        <property type="entry name" value="MeTrfase_TrmA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010280">
        <property type="entry name" value="U5_MeTrfase_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11061">
        <property type="entry name" value="PTHR11061"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01938">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05958">
        <property type="entry name" value="tRNA_U5-meth_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51687">
        <property type="entry name" value="SAM_MT_RNA_M5U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01231">
        <property type="entry name" value="TRMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TRAM" evidence="5">
        <location>
            <begin position="12"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="405"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="334"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="378"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH85285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="452" mass="48797" checksum="CDA95D14A747CF91" modified="2015-07-22" version="1">MPEEQQAHATSPPLVGEEYEVEIGPVAHGGHCVARTPEGQVLFVRHTLPGERVVARVTEGRAGARFLRADAVRVLEPAKDRIEAPCPYAGPGKCGGCDFQHVAPGAQRRLKADVLAEQLTRLAGLTAEDAGWDGTVEPVPGDKVPKGEVPAWRTRVQYAIDPEDHAGLRKHRSHEVQPVDRCLIAAPEVEELGVESREWPQLATVEAIAATGSGDRQVVLTPRPGGRLPLVELDRPVSVLRAEEPRTPGAPAAIHRVHGRDFVRERAAGRTWRVGAGGFWQVHPRGADLLVETVMTGLMPKKGDMALDLYCGVGLFAGALAERVGPKGAVLGIESGKRAAADARHNLADLDRVRIEQGKVDRVLPRTGITEADLVVLDPPRTGAGRQVITQITALHPRRIAYVACDPAALARDLSYFTAAGYTPKWTRAFDLFPMTHHMECVAVLVRAEKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9T8</accession>
    <name>A0A0F7N9T8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cystathionine gamma-lyase</fullName>
            <ecNumber evidence="5">4.4.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_15905</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.1" evidence="5"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_15905"/>
    <dbReference type="EnsemblBacteria" id="AKH83447">
        <property type="protein sequence ID" value="AKH83447"/>
        <property type="gene ID" value="AA958_15905"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_15905"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3351"/>
    <dbReference type="OrthoDB" id="637281at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004123">
        <property type="term" value="F:cystathionine gamma-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080146">
        <property type="term" value="F:L-cysteine desulfhydrase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044540">
        <property type="term" value="F:L-cystine L-cysteine-lyase (deaminating)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808">
        <property type="entry name" value="PTHR11808"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH83447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="415" mass="43130" checksum="DDEFC5BC18CC2BD6" modified="2015-07-22" version="1">MTPDDTPHADPPPRHTAETPETPETPEAADSVAADATRVVRAGLPAPEPYEPALPGPVFAAHYHLPGDVTAAPYDYGRDANPTWTRLEAALAELESPGVPAEAVAFASGMAAITAVLMAVPGPPRDGGAPRGHVVLPSDGYNLVPGGLRALLQEHGTDVRTAPTAGDAQAELLDGARLLWLETPSNPGLDVCDIRRLAAAAHAAGALVAVDNTLPTPLGQRPLELGADLSVASGTKALTGHGDVLLGYAVTRDPALARRLRTWRKTAGAIPGPMEAWLAHRSLATLELRTGRQAANALAVAEALRATPGVRDVRHPGLPSDPAHALAARQMRAGRYGCVVAFTLPDRAAAERFLGAARLVDEATSFGGVRSTAERRGRWGGDAVPEGFVRFSAGVEDSADLVADLREALAYALGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9U5</accession>
    <name>A0A0F7N9U5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Translation initiation factor IF-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">infA</name>
        <name evidence="5" type="ORF">AA958_21125</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IF-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018834859.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_21125"/>
    <dbReference type="EnsemblBacteria" id="AKH84278">
        <property type="protein sequence ID" value="AKH84278"/>
        <property type="gene ID" value="AA958_21125"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_21125"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4448"/>
    <dbReference type="OrthoDB" id="2066663at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04451">
        <property type="entry name" value="S1_IF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00075">
        <property type="entry name" value="IF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006196">
        <property type="entry name" value="RNA-binding_domain_S1_IF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004368">
        <property type="entry name" value="TIF_IF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33370">
        <property type="entry name" value="PTHR33370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01176">
        <property type="entry name" value="eIF-1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00008">
        <property type="entry name" value="infA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50832">
        <property type="entry name" value="S1_IF1_TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2 3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="2 3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="S1-like" evidence="4">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH84278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="74" mass="8724" checksum="C546F48F271D0CD3" modified="2015-07-22" version="1">MTKDKNVIEAEGRVVECLRSAMFTVELENGHRVLAHISGKMRKHYIRINLEDRVLVELPPYDLARGRIVFRYRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NA49</accession>
    <name>A0A0F7NA49_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_27880</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018654.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_27880"/>
    <dbReference type="EnsemblBacteria" id="AKH85420">
        <property type="protein sequence ID" value="AKH85420"/>
        <property type="gene ID" value="AA958_27880"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_27880"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5877"/>
    <dbReference type="OrthoDB" id="1977328at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025645">
        <property type="entry name" value="DUF4349"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14257">
        <property type="entry name" value="DUF4349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519235" evidence="3">
        <location>
            <begin position="31"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="270"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH85420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="322" mass="32744" checksum="A27B55D8BBF63CC1" modified="2015-07-22" version="1">MPARISTRPALAAALLAAALAVGGCSGSGADSADGGSARDDAKAQGAAPREDGGADAGGDSADSSAPRGGATAAEGVTLAPQALVRTAAITIRTKDLAGAADSARTLAEGAGGYVGDESTSQEPGAPARARLTLRVPAGEYDAVLGDLAELGRVVDRDVEVKDVTDEVVDVDSRVRSQRASVARIRDLMDDATKLADVVTLEGELGTRQADLEALLAQQSSLKERTELGTITLELRRPAAAPPADEDDGTGVTDALAGGWDAFVTGLRGVLIAVSASLPFAALLVLLALAWRWLRGRLPRRHIAPPPSPFPGQPTPQGGEPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NA50</accession>
    <name>A0A0F7NA50_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="6">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AA958_21660</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the helicase family. UvrD subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="6"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017635.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_21660"/>
    <dbReference type="EnsemblBacteria" id="AKH84373">
        <property type="protein sequence ID" value="AKH84373"/>
        <property type="gene ID" value="AA958_21660"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_21660"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4562"/>
    <dbReference type="OrthoDB" id="137860at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006268">
        <property type="term" value="P:DNA unwinding involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005751">
        <property type="entry name" value="ATP-dep_DNA_helicase_PcrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013986">
        <property type="entry name" value="DExx_box_DNA_helicase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00580">
        <property type="entry name" value="UvrD-helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01073">
        <property type="entry name" value="pcrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51217">
        <property type="entry name" value="UVRD_HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="8">
        <location>
            <begin position="37"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="UvrD-like helicase C-terminal" evidence="9">
        <location>
            <begin position="350"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="267"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="58"/>
            <end position="65"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AKH84373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="817" mass="89314" checksum="0CCB758542606699" modified="2015-07-22" version="1">MSSLFDDSHLALAASTPEPYYRDGAPRPVTDPEALLTGLNEQQRAAVEHTGSPLLIVAGAGSGKTRVLTHRIAYLLAKRRAHPGQILAITFTNKAAGEMKERVEELVGARANAMWVSTFHSACVRILRRESKKLGFTSSFSIYDAADSRRLMALVCRDLDLDPKRYPPKALSARVSSLKNELIDEESWAAQAVDGFEKTLAEAYALYQSRLREANALDFDDLIMTTVNLLQAFPDVAEHYRRRFRHVLVDEYQDTNRAQYMLVRELVGPPAGPPGEGGAAAPEEDGAAAADGGGVRTTGPEGPAELCVVGDADQSIYAFRGATIRNILQFEEDYPEARTILLEQNYRSTQTILNAANAVIERNASRRPKNLWTDAGAGARIVGYVADTEHDEAQFVADEIDRLSDAGEARAGDVAVFYRTNAQSRVFEEVFIRVGLPYKVVGGVRFYERREVRDVLAYLRVLANPEDSVPLRRIMNVPKRGIGDRAEAMIEALAQRERISFPQALVRVDEAYGMASRSVNAVKRFNVLMEELRTVVESGAGPATVLEAVLEQTGYLAELQASTDPQDETRIENLQELAAVALEFEQERGEEGPGTLADFLERVALVADSDEIPEEETDGSGVITLMTLHTAKGLEFPVVFLSGMEDGVFPHMRALGDVKELEEERRLAYVGITRAQERLYLTRSVMRSSWGQPSYNPPSRFLDEIPPAYVEWRRTGASATRGGGGGRSPMESAAAALASSTSAARTRQGPSGFATGRATERPVIALSVGDRVTHDQFGMGTVVEVSGSGANAQATIDFGDGGRTKKLLLRYAPVEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NA96</accession>
    <name>A0A0F7NA96_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Beta-N-acetylhexosaminidase</fullName>
            <ecNumber evidence="3">3.2.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AA958_22005</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="3"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017685.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_22005"/>
    <dbReference type="EnsemblBacteria" id="AKH84423">
        <property type="protein sequence ID" value="AKH84423"/>
        <property type="gene ID" value="AA958_22005"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_22005"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4634"/>
    <dbReference type="OrthoDB" id="727559at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004563">
        <property type="term" value="F:beta-N-acetylhexosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102148">
        <property type="term" value="F:N-acetyl-beta-D-galactosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025705">
        <property type="entry name" value="Beta_hexosaminidase_sua/sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015882">
        <property type="entry name" value="HEX_bac_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02838">
        <property type="entry name" value="Glyco_hydro_20b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00738">
        <property type="entry name" value="GLHYDRLASE20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="SSF55545"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_20b" evidence="8">
        <location>
            <begin position="109"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_20" evidence="7">
        <location>
            <begin position="240"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="60"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="90"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH84423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="589" mass="63703" checksum="C39F90216D78F7E5" modified="2015-07-22" version="1">MRFPPRPSRPPRRSPAGRHAHRPGGPLRALRGPRRALYWAVATVLATAAVLLALRPVLDGGDGDGTPRSGVGAAAHRTGQGQAPATPTPGGEDFPAPPRGDRGTPLPDPRTVPAVRSYERADGTGWRPADRAVVIAEDDALTDESMRLAAELGMLYAKAPGGDGPPDSGQRGGDIRLRLDPGRAGGPEAYRIDVADGRATVTAATDTGVFYGTRTLLQAARAGGGVPPGRIDDRPDRRQRGFMVDIARKHFSAAWLSDRLREMADLKLNQLHLHLSDDQAFRIESDSHPEVVSDPHLTKAQVRDILDLAADLHITVIPEIDSPGHLGAVLDAHPDLQLKTPEGSPVEGAIDISEPRAARIVDDLLTEYARLFPGPYVHIGGDEYVALMASDPEARYPDLAAAARERFGAGAAVADLNAAWLNERADTVRERGKKVKAWNDGFIPGAKVSPDRDREVEYWTGKEAFARDPQAFLEDGWRLVNLNDEYLYYVLGEPNDFTYPTGKRIYEEWTPAVLRGTRPVPERLAGPGKVLGARFAVWGDRAGAQTPEQVAEGVRLPLAALAQKVWDPREPRLGWGEFADLAGTVRGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NA97</accession>
    <name>A0A0F7NA97_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GMP synthase [glutamine-hydrolyzing]</fullName>
            <ecNumber evidence="9">6.3.5.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">GMP synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Glutamine amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 12" type="primary">guaA</name>
        <name evidence="12" type="ORF">AA958_21610</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Catalyzes the synthesis of GMP from XMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O + L-glutamine + XMP = AMP + diphosphate + GMP + 2 H(+) + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:11680"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Purine metabolism; GMP biosynthesis; GMP from XMP (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.2" evidence="9"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017626.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_21610"/>
    <dbReference type="EnsemblBacteria" id="AKH84364">
        <property type="protein sequence ID" value="AKH84364"/>
        <property type="gene ID" value="AA958_21610"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_21610"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4551"/>
    <dbReference type="OrthoDB" id="504464at2"/>
    <dbReference type="UniPathway" id="UPA00189">
        <property type="reaction ID" value="UER00296"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003922">
        <property type="term" value="F:GMP synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016462">
        <property type="term" value="F:pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01742">
        <property type="entry name" value="GATase1_GMP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01997">
        <property type="entry name" value="GMP_synthase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00344">
        <property type="entry name" value="GMP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001674">
        <property type="entry name" value="GMP_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004739">
        <property type="entry name" value="GMP_synth_GATase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022955">
        <property type="entry name" value="GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025777">
        <property type="entry name" value="GMPS_ATP_PPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00958">
        <property type="entry name" value="GMP_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00884">
        <property type="entry name" value="guaA_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00888">
        <property type="entry name" value="guaA_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51553">
        <property type="entry name" value="GMPS_ATP_PPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="5 9 10" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="3 9 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GMPS ATP-PPase" evidence="11">
        <location>
            <begin position="200"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="227"/>
            <end position="233"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AKH84364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="524" mass="56279" checksum="66D8287FDF1FE7A1" modified="2015-07-22" version="1">MTSATPDTVLVVDFGAQYAQLIARRVREARIYSEIVPHTMPVPEILAKNPKAIILSGGPSSVYAEDAPGIDPAIFTAGVPVFGMCYGFQLMAQALGGTVDNTGSREYGRTRLDVTRPDSTLFTGTPERQDVWMSHGDACSAAPAGFTVTASTEGVPVAAFEDDERKLYGVQHHPEVVHSTHGQLVLEHFLYRGAGLAPTWTTANVVEESVAAVRAQVGDAQAICALSGGVDSAVAAALVQRAIGDRLTCVYVDHGLMRKGESEQVEKDFVAATGVQLKVVDAAERFLTALAGVSDPEQKRKIIGREFIRVFEQAQAEIVAAAGETGAPVRFLVQGTLYPDVVESGGGTGTANIKSHHNVGGLPEDLDFELVEPLRRLFKDEVRMVGKELGLPEAMVQRQPFPGPGLGIRIVGEVTKDRLDLLREADAIAREELTAAGLDRDIWQCPVVLLADVRSVGVQGDGRTYGHPVVLRPVSSEDAMTADWSRLPYDVLARISTRITNEVADVNRVVLDVTSKPPGTIEWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAA5</accession>
    <name>A0A0F7NAA5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Heme ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_22065</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017695.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_22065"/>
    <dbReference type="EnsemblBacteria" id="AKH84433">
        <property type="protein sequence ID" value="AKH84433"/>
        <property type="gene ID" value="AA958_22065"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_22065"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4648"/>
    <dbReference type="OrthoDB" id="551294at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
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        <property type="entry name" value="ABC_tran"/>
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    </dbReference>
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        <property type="entry name" value="AAA"/>
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        <property type="match status" value="2"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 7" id="KW-0067">ATP-binding</keyword>
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    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519903" evidence="5">
        <location>
            <begin position="21"/>
            <end position="555"/>
        </location>
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        <location>
            <begin position="23"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="272"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="512"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="55"/>
            <end position="62"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AKH84433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="555" mass="58718" checksum="625D87AA867EA729" modified="2015-07-22" version="1">MCAITALSSSSTAADPPAGAAAVELHGITKRFPGVVANHDIDITVRRGTVHALVGENGAGKSTLMKILYGMQKPDEGTITLDGTEVAFASPADAIARGIGMVHQHFMLADNLTVLENTVLGSEKLHGIGDRARARIKELSDAYGLGIRPDVLVEDLGVADRQRVEILKVLYRGARTLILDEPTAVLVPQEVDALFDNLRGLKAEGLTVLFISHKLGEVLAVADDITVIRRGTTVASVKPADVTSKQLAELMVGSELPTPETRESTVTDIPMLRVGDLHLCAVDPDGVSREVLDRISFTIHKGEVLGIAGVEGNGQSELVETIMGLRHPDTGSIVLDGADISHAATRKRREGGIGYIPEDRQRHGLLLEAPLWENRILGHTTESPNSRGVLIDAAAARKDTKRIVEEYDVRTPGIDVTAASLSGGNQQKLIVGREMSHSPKLLIAAHPTRGVDVGAQADIWEQIRAARREGLAVLLISADLDELIGLSDTLRVMYRGRLVADADPAAITPEELGSAMTGAASGHLEDGAAPRDAAVPDPRSAAGGSDDGQGGGRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAE9</accession>
    <name>A0A0F7NAE9_9ACTN</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_22320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_22320"/>
    <dbReference type="EnsemblBacteria" id="AKH84478">
        <property type="protein sequence ID" value="AKH84478"/>
        <property type="gene ID" value="AA958_22320"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_22320"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4700"/>
    <dbReference type="OrthoDB" id="2079742at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH84478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="117" mass="12686" checksum="024A21199DD81B56" modified="2015-07-22" version="1">MTISTAGQPLIPQPAATVTTLRQAVSQIAPAALPAFTRELDQAADQTRQGSEMGPLQRFIAQWAVYVHIQRHPDMAAQLRYWEDTAQGDDSAQARRAVSEIGKILDAAHTALGIPIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAS5</accession>
    <name>A0A0F7NAS5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serine/threonine protein phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_18100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017102.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_18100"/>
    <dbReference type="EnsemblBacteria" id="AKH83802">
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        <property type="gene ID" value="AA958_18100"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_18100"/>
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    <dbReference type="OrthoDB" id="1377603at2"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005532">
        <property type="entry name" value="SUMF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042095">
        <property type="entry name" value="SUMF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03781">
        <property type="entry name" value="FGE-sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="SSF56436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FGE-sulfatase" evidence="1">
        <location>
            <begin position="53"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="328" mass="35226" checksum="FA2D3716010F0C85" modified="2015-07-22" version="1">MGGGGVEPGACCAPGRGAEGAAVPEGGGVVAGPGKAVAASGPAAYEPRGGWRKLPGGAFLMGYDDGPYPADGEGPAREVTVDGFAVAATAVTNEGFAAFTDATSYVTDAERFGWSFVFAGFLPKNFPPTASPPQTPWWRQVHQADWRHPEGPGSGLRGRWDHPVVHVSHTDALAFCDWAGARLPTEAEWEYAARGGLEGEPYPWGAERDPEGAYRMNIWRGSFPDRNTAADGYRGTCPVDAFEPNDYGLYNATGNVWEWCADWFHARHHRKAPRDNPRGPRLGQSRVLKGGSHLCHESYCLRYRTSARMGNTPDSSSGNTGFRAIRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAS6</accession>
    <name>A0A0F7NAS6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">4-hydroxy-tetrahydrodipicolinate reductase</fullName>
            <shortName evidence="9">HTPA reductase</shortName>
            <ecNumber evidence="9">1.17.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">dapB</name>
        <name evidence="12" type="ORF">AA958_26405</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(S)-2,3,4,5-tetrahydrodipicolinate + H2O + NAD(+) = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:35323"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16845"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:67139"/>
            <dbReference type="EC" id="1.17.1.8"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(S)-2,3,4,5-tetrahydrodipicolinate + H2O + NADP(+) = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:35331"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16845"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:67139"/>
            <dbReference type="EC" id="1.17.1.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="9">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 4/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the DapB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.</text>
    </comment>
    <dbReference type="EC" id="1.17.1.8" evidence="9"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018416.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_26405"/>
    <dbReference type="EnsemblBacteria" id="AKH85176">
        <property type="protein sequence ID" value="AKH85176"/>
        <property type="gene ID" value="AA958_26405"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_26405"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5559"/>
    <dbReference type="OrthoDB" id="803114at2"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00018"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008839">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate reductase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016726">
        <property type="term" value="F:oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00102">
        <property type="entry name" value="DapB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022663">
        <property type="entry name" value="DapB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000846">
        <property type="entry name" value="DapB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022664">
        <property type="entry name" value="DapB_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023940">
        <property type="entry name" value="DHDPR_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20836">
        <property type="entry name" value="PTHR20836"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05173">
        <property type="entry name" value="DapB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01113">
        <property type="entry name" value="DapB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000161">
        <property type="entry name" value="DHPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00036">
        <property type="entry name" value="dapB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01298">
        <property type="entry name" value="DAPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0520">NAD</keyword>
    <keyword evidence="4 9" id="KW-0521">NADP</keyword>
    <keyword evidence="6 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DapB_N" evidence="10">
        <location>
            <begin position="6"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="DapB_C" evidence="11">
        <location>
            <begin position="112"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="(S)-2,3,4,5-tetrahydrodipicolinate binding" evidence="9">
        <location>
            <begin position="146"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="11"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="79"/>
            <end position="81"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="106"/>
            <end position="109"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>(S)-2,3,4,5-tetrahydrodipicolinate</name>
            <dbReference type="ChEBI" id="CHEBI:16845"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AKH85176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="251" mass="26110" checksum="97FD03D9D619F14C" modified="2015-07-22" version="1">MTTQLKVGVIGARGRIGSEAAGAVEAAGDMDLVAAVDRDDDLAELTRAGAQVAVELTHPDSAPANVDFCVRHGIHAVVGTTGWTDDRLAALRARLAESPGTGVLIAPNFSLGAVLTMHFARQAARFFESAEVVELHHPNKADAPSGTATRTARLIAEARREAGLPPQPDATATALPGARGADVDGVPVHAVRLRGLLAHQEVLLGDTGETLTIRHDSLHHSSFMPGILLAARRVPGTPGLTVGLEHFLDLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NB93</accession>
    <name>A0A0F7NB93_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AtrA protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_23820</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017986.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_23820"/>
    <dbReference type="EnsemblBacteria" id="AKH84734">
        <property type="protein sequence ID" value="AKH84734"/>
        <property type="gene ID" value="AA958_23820"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_23820"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5020"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519271" evidence="3">
        <location>
            <begin position="24"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="PBPb" evidence="4">
        <location>
            <begin position="69"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="34"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH84734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="307" mass="32040" checksum="96B00A43A1D77B43" modified="2015-07-22" version="1">MSPRTTRRTGAAKSRLVAVGALAAAGALVLSSCGDQTDDGGDGGDGGESKTSSNAAPGALPKAIKDAGVIKVGSDIAYAPMEFDQGGKPAGVDIDIANALGEELGVEFQFQNNVFDNLIPSLDSGRFDIIMSSMTDNKERQAEVDFVDYFSAGVSILVQKGNPEGISTLDDLCGKTVAFQRGTVSADIAKAQNEKCDKPIKTLPFTKDTEALQQVKQGRAVADLNDFPVAAYNARESGGGEDFEVVGEQIDAAPYGIAVSKDNAELRDALAAALDAIIENGEYQKVLEKWEVQQGGVDKATVNGGNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBJ7</accession>
    <name>A0A0F7NBJ7_9ACTN</name>
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        <submittedName>
            <fullName evidence="3">Phenylacetic acid degradation protein PaaI</fullName>
        </submittedName>
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        <name evidence="3" type="ORF">AA958_30525</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioesterase PaaI family.</text>
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    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019063.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_30525"/>
    <dbReference type="EnsemblBacteria" id="AKH85835">
        <property type="protein sequence ID" value="AKH85835"/>
        <property type="gene ID" value="AA958_30525"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_30525"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6451"/>
    <dbReference type="OrthoDB" id="1814691at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039298">
        <property type="entry name" value="ACOT13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003736">
        <property type="entry name" value="PAAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660">
        <property type="entry name" value="PTHR21660"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00369">
        <property type="entry name" value="unchar_dom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4HBT" evidence="2">
        <location>
            <begin position="57"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH85835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="151" mass="16310" checksum="61978B982E33D347" modified="2015-07-22" version="1">MEDESQSGEASPAVQKRVRESFDRQGLMRHLGARISLIAPGRVHIVLPARPEVTQQHGYFHAGATSAIADSAGGYAGYTLFPEDADVLTVEYKINLLAPAVGEYLEAVGTVLKSGRTLTVCGLEVFGHRADGVRKLVANGQQTLIRVPRER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBM3</accession>
    <name>A0A0F7NBM3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_28800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018814.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_28800"/>
    <dbReference type="EnsemblBacteria" id="AKH85581">
        <property type="protein sequence ID" value="AKH85581"/>
        <property type="gene ID" value="AA958_28800"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_28800"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6069"/>
    <dbReference type="OrthoDB" id="1928091at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="286" mass="30671" checksum="0F10D37CA7FD3CD9" modified="2015-07-22" version="1">MSVLVTGATGAVGQRFVPRLLQWAGGEEVRLLVRDEERAAPLAGRGARLVVGDLREPGDRRRALAGVRDVVHVAAAFRDVPDEEAYAVNRDATLALGAEAAAAGVRRFVFTSTNLVYGAGRGRPAVETDEPRGDGPLAGAYPRSKTAAEQGLLELHRGRGLDVRVARLAFVYGEGDGHLEASLRWTPHMAAHQRIQMVHQADVARALWRVLSAPGLAGRVYNVADDAPVSALELLHLVGAPVPEGMAERASDDPWHGVVSNERIRAELGFRPLYPSLWTARDAGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBY9</accession>
    <name>A0A0F7NBY9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Protein rarD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AA958_20690</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EamA transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017493.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_20690"/>
    <dbReference type="EnsemblBacteria" id="AKH84207">
        <property type="protein sequence ID" value="AKH84207"/>
        <property type="gene ID" value="AA958_20690"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_20690"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4364"/>
    <dbReference type="OrthoDB" id="1391352at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004626">
        <property type="entry name" value="RarD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22911:SF114">
        <property type="entry name" value="PTHR22911:SF114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00688">
        <property type="entry name" value="rarD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
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            <end position="129"/>
        </location>
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        <location>
            <begin position="136"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="159"/>
            <end position="176"/>
        </location>
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            <begin position="188"/>
            <end position="208"/>
        </location>
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            <begin position="220"/>
            <end position="244"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
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        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
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        <location>
            <begin position="17"/>
            <end position="153"/>
        </location>
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        <location>
            <begin position="162"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="319"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AKH84207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="346" mass="36759" checksum="5F6046AF50A1943C" modified="2015-07-22" version="1">MGSSGEAPARAASEARLGLLYGFAAYGSWGVIPLFWPLLEPASPAEILANRMVWSLVACILLLLVLRRWAWIRPLLREPRRLALVAGAAATITVNWFVYIWAVNSGHVVEAALGYFINPLVSIAFGVLLLRERLRALQWIAVAVGAAAVVVLTVGYGRLPWIALVLAFSFGTYGLIKKRIGLEGIESFAAETAVQFLPALVFMLVLGARGDSTFHTEGAGHALLLASCGVITAFPLICFGAAAVRLPLSTIGLMQYLAPTLQFALGVLYFRESMPAERWAGFLLVWLALALLTYDALRTARRGRLELRRAEAEARAAAAGDAGDAGGAAGPAAAGVPEAVNPGRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBZ4</accession>
    <name>A0A0F7NBZ4_9ACTN</name>
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        <submittedName>
            <fullName evidence="4">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_20720</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
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    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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        <property type="gene ID" value="AA958_20720"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
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        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH84212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="438" mass="47763" checksum="925B0B9FA3F91C03" modified="2015-07-22" version="1">MDSTAYAPEARRPRLPLALRAPFEARTWREFLYHLLSLPVSIVFFVYTITMLSLGLGLLITFLGVPVLAAMLAGCRGMGYVERTRARLLLDLHVDDPEPLHRRASGFMGWVGSLFRSGESWRTMLYGLLHMFWAVCSFTLSVAVMFWSWSMVTYPLWQWVFPAHWGQDGLQVYGNADGDGWYLDSPLEQLFAVGVGAVFLLASPWVVRSLSYVDRAMVVGLLGPSKLATRVQELETDRGVVVDTAAADLRRIERDLHDGAQARLVALAMDLGLAKEKLLEDPEAAAAMVDEAHGEVKLALQELRDLARGIHPAILTDRGLGPALSAVAARCTVPVSVTVDLLERPAQSIEGIAYYTTSELLQNISKHSGASRAMVDLWRAEGRLMIQVTDDGNGGARLDAGSGLSGLAERLGSVDGLLVVDSPPGGPTVVTAELPWRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NC00</accession>
    <name>A0A0F7NC00_9ACTN</name>
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        <submittedName>
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        </submittedName>
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    </gene>
    <organism evidence="3 4">
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        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
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    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_31475"/>
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    <dbReference type="OrthoDB" id="1036370at2"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:regulation of transcription, DNA-templated"/>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
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        <property type="entry name" value="GerE"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="270"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH85990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="338" mass="35953" checksum="D0685D9B54DE15DF" modified="2015-07-22" version="1">MLEPAGVEPTEERVYRLLVGLHGADAESVAAELGLDRRRAESLLTSLQEKGLVSGPEQRPGGGGHFVAVAPDVALGPRLLRGQEALERARRGVTELAEEFRAGGRRRDARQLVEVVTGVAAIRQQIRDLAYGARTEVLALCKAGHVAMPSEENDEEFEMLAKGVRYRVIYERALLEEPGMLGNVALGVRAGEAARAASALPVRLMIADGALALCPLVPNADSRFGEPTVAVVRSSALLDALIALFESQWAAASPLHVTGAGELAGLGEGTGAAGPALAEDERYLLSLVVAGLADKAIATQLGISQRTVQRRLRDMMGRVGADTRAQLVWQAARRDWLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NC11</accession>
    <name>A0A0F7NC11_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cysteine desulfurase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_31605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019238.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_31605"/>
    <dbReference type="EnsemblBacteria" id="AKH86010">
        <property type="protein sequence ID" value="AKH86010"/>
        <property type="gene ID" value="AA958_31605"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_31605"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6675"/>
    <dbReference type="OrthoDB" id="446447at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011340">
        <property type="entry name" value="Cys_dSase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01976">
        <property type="entry name" value="am_tr_V_VC1184"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotran_5" evidence="1">
        <location>
            <begin position="21"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="405" mass="42248" checksum="2D08340FD0A31608" modified="2015-07-22" version="1">MTYDLAALRARIPALKDGTAYFDGPGGTQTPAPVIEAMAAALAAPLSNQGHVTAAERNAEAIVAGARAALADLLGVPADGVVFGRSATQLTYDVARTLARAWGPGDEVVVTRLDHDANIRPWVQAAERAGAAVRWCDFDPDTGELTPGHLAAVLTERTRLVAVTAAANLLGTRPPVPELARMAHDAGALVHVDAVHYAAHAAVDAAALGADFVVCSPYKFLGPHLGVLGARPELLRSLAPDKLLPATDAVPQRFEQGTLPYELLAGARAAVDFLAGLDPEPAAGGDRRARLIRAYAAIEAHEDALRLRAEDGLAALPGVTLRSRAGHRTPTLLLTLEGRTTEDAYRFLAERGVNAPSGSFYALEASRRLGLGDSGGLRAGLAPYSSADDVDRLVAGLGEFLRTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NC16</accession>
    <name>A0A0F7NC16_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sugar-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_31695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019253.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_31695"/>
    <dbReference type="EnsemblBacteria" id="AKH86025">
        <property type="protein sequence ID" value="AKH86025"/>
        <property type="gene ID" value="AA958_31695"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_31695"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6693"/>
    <dbReference type="OrthoDB" id="1746871at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519946" evidence="1">
        <location>
            <begin position="33"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="433" mass="47208" checksum="9C942C033B0F8BB1" modified="2015-07-22" version="1">MKTRRRMPRILAGGVALGLTLTLAACGDDGGSASGENEFTVLVYGDATNKVEKKLVDEFNKTSEVKARLDTIPGADYQQKLQTIISTPQAPDVFFHWGGGSIKPFVDADLLLPLDDFIKKDPGLKDNFLPSVFDASVVDGKAYGVPMRGTQPVMLFHNKKVLADAGVEPPETWDDLLAAVAELKDAGVTPIALGGGDMWPTQMWFQYLYDRIAGPELFQQALDGDKEAWASEDSRRALGMIRELVDAGAFGDTYDSVKFTNNGSPQLVASGKAGFELMGSWYYSTQQSLNEEFAAEDLGYSAFPSVDGGKGDPANLAGNTNNYYSVMKKAEHPEAIAEFLKLMYSDQFVKDQLSIGNLPTTANTPDFLDQAASPEYSKYQYDLVEKAPHFQLSWDQAYPQSAATDMHKAVQQFFNGGIDEDGFISAMQALPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NC55</accession>
    <name>A0A0F7NC55_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_30320</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_30320"/>
    <dbReference type="EnsemblBacteria" id="AKH85801">
        <property type="protein sequence ID" value="AKH85801"/>
        <property type="gene ID" value="AA958_30320"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_30320"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6405"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="238"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="311"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="340"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="368"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="454"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="20"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="480"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH85801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="502" mass="51800" checksum="4484A1C86C13B406" modified="2015-07-22" version="1">MSGPDSTANRAPQKAGSGAILAFVCLGQFMVFTDVSIVNLALPSIQEGLDMTDVSLNYIVTAYATVLGGFLLFGGRLADTFGRRRLIQIGFTLFALASLVSGLAENGPTLIAARGVQGFGAALITPAALAILTNTFAEGPERNKALGVWGSLSGIASIAGVILGGVLADGPGWEWIFWINVPIGLGAALFAVRILPESRAEERSQFDSLGAATLTAGLLLLIFTLGEATHVGWGTFRTIGSLIGVAVLLTGFIVIESLVKSPMMPLRIFRLKTMRVANISAVLVFGTFAALFFFASLFMQNAFGYTPLEAGFAYVPLAVSVAAGAGIASGLVAKFPPRNLVMAGLVLAVVGLLLMWRAPADGTYLVDLLTPFILLGLGCGIVFVTLQIAAFVGVSDEEAGVGAGLINTSQEAGGALGLAIIATIAYSGIDSEMEATGGDPELIMNIQESANHDAFLSGAVLGVIALLVVAFLMPRADAGASHAEDDGKNLNETDLAPAESDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NC80</accession>
    <name>A0A0F7NC80_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NADAR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_30505</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + H2O = 2,5,6-triamino-4-hydroxypyrimidine + D-ribose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23436"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58614"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:137796"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-amino-6-(5-phospho-D-ribosylamino)uracil + H2O = 5,6-diaminouracil + D-ribose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:55020"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:46252"/>
            <dbReference type="ChEBI" id="CHEBI:58453"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019059.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_30505"/>
    <dbReference type="EnsemblBacteria" id="AKH85831">
        <property type="protein sequence ID" value="AKH85831"/>
        <property type="gene ID" value="AA958_30505"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_30505"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6446"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd15457">
        <property type="entry name" value="NADAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012816">
        <property type="entry name" value="NADAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037238">
        <property type="entry name" value="YbiA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08719">
        <property type="entry name" value="NADAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143990">
        <property type="entry name" value="SSF143990"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02464">
        <property type="entry name" value="ribofla_fusion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADAR" evidence="3">
        <location>
            <begin position="26"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH85831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="192" mass="20809" checksum="A650F8DE65065AD4" modified="2015-07-22" version="1">MGELPGSVAELRAAAEEGRKLKYLYFWGHRPKRQDVVDAACLSQWWPVEFEVDGVGYVTAEHWMMAAKARLFGDEAAVARILATRHPGAAKAEGRKVRGFDEAVWEEHRFAAVVRGNLAKFGRHPGLGAYLLGTGSRILVEASPVDRVWGIGLAATDDRAQDPGAWRGLNLLGFALMEVRATLAARAAAAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCJ7</accession>
    <name>A0A0F7NCJ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_22060</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017694.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_22060"/>
    <dbReference type="EnsemblBacteria" id="AKH84432">
        <property type="protein sequence ID" value="AKH84432"/>
        <property type="gene ID" value="AA958_22060"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_22060"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4647"/>
    <dbReference type="OrthoDB" id="974216at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="319"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH84432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="367" mass="39243" checksum="4DE73D34D2A1EC84" modified="2015-07-22" version="1">MKRLDRDKLITAVGAPVLAVFAALVLTSLIILISGKDPFRAYQVMIEFGTTDRSAIYIVNKSTMFFLSALAVAIGFRMNLFNIGVDGQYRIAAFFAAAVGGALSLPGIIQIPLIILVAMGVGAIWAGIAGVLRTTRGVSEVITTIMLNSIAGAVIGYYLTAGRLGEKDGNLTHTPNIPSSSHIFMIETSVGDINGFVVFAVLAGFLYWFVLNRTRFGFDLRSVGQSETAAAASGVDVKRMIVTSMVLSGAVAGLVGMPTLLGESYNYGTDFPLGVGFTGIAIALLGRNHPVGIALGALLWAFLERTGTQLEFEGYDQKIVEVIKGIIVLCVVIAYEVVRRWALRDQQRRVGEELAQARKTEKAEVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCJ8</accession>
    <name>A0A0F7NCJ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Multidrug ABC transporter ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_31080</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019149.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_31080"/>
    <dbReference type="EnsemblBacteria" id="AKH85921">
        <property type="protein sequence ID" value="AKH85921"/>
        <property type="gene ID" value="AA958_31080"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_31080"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6568"/>
    <dbReference type="OrthoDB" id="1926714at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="7"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="257"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="39"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH85921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="298" mass="32225" checksum="543832D0D39D11CF" modified="2015-07-22" version="1">MSAAAAVAVEGLRMRYGAADVLHGVDLHVRYGETVALLGPNGAGKTTTIEILEGFRPRSAGEVAVLGTDPAQGDERWRARVGVVLQSWRDHGKWRVRELLAHLASYYACAGRTPWDPGELADAVGLGGRGEQKIRTLSGGQRRRLDVAIGIVGRPDLLFLDEPTTGFDPEARRGFHRLVRDLRAAGTTVLVTTHDLHEAEVLADRIVILDAGRVLADGTPAELARRIAGADRVRWRHRGRPRVHATDDSTAFVRGLFERHGEEIAELEVRRASLEQTYLALVQAAEGAPAGAAEGGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7ND15</accession>
    <name>A0A0F7ND15_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminotransferase</fullName>
            <ecNumber evidence="1">2.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_23235</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.-" evidence="1"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017888.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_23235"/>
    <dbReference type="EnsemblBacteria" id="AKH84632">
        <property type="protein sequence ID" value="AKH84632"/>
        <property type="gene ID" value="AA958_23235"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_23235"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4898"/>
    <dbReference type="OrthoDB" id="417859at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019880">
        <property type="entry name" value="OxyQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03539">
        <property type="entry name" value="DapC_actino"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="2">
        <location>
            <begin position="30"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH84632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="368" mass="39483" checksum="E7B9CC4B7C3244CB" modified="2015-07-22" version="1">MRPVTSRLPVFPWDRLEPYKTAAAAHPGGIVDLSVGTPVDPVPEVVRAALADAADSPGYPLAWGTPALREAIAGWFGRRLGAELRPDAVLPAIGTKELVGWLPTLLGLEPGDQVAYPSLAYPTYEIGALTARAEPVTYADPVTDLDPARVKLLWLNTPSNPTGRTMDAAELRRAVAWARAHGVLVASDECYLELGWETEPVSVLHPSVSEGSYEGLLAVHSLSKRSSLAGYRAGFAGGDAAVVRELVAVRKHTGMMVPKPVQQAMIAALGDGRHVAEQRERYARRRAALREALTGAGFRIEHSEASLYLWVTRDEPCWDTVAELAKLGIAVAPGEFYGAAGERFVRVAFTATDERVAAAVERLAALRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7ND70</accession>
    <name>A0A0F7ND70_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sugar ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_27355</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018568.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_27355"/>
    <dbReference type="EnsemblBacteria" id="AKH85333">
        <property type="protein sequence ID" value="AKH85333"/>
        <property type="gene ID" value="AA958_27355"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_27355"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5765"/>
    <dbReference type="OrthoDB" id="1378040at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519418" evidence="1">
        <location>
            <begin position="21"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_4" evidence="2">
        <location>
            <begin position="50"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH85333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="342" mass="34850" checksum="4F9C38602D352FF8" modified="2015-07-22" version="1">MARIRFVSSGVAAALAVVFAAGGVAAGKAAFDDSGSSSGGGAAVGGTKVDVITKATDSDFWQSMLAGSKQAGDDFGIDLGLFGPTSETDIEEQVSLVENSISRGADAIVLASNSSTALNGAVDRARNAGIKVITVDNAVTTEAEGFIGTDNVKAGEQAGVRMCELLTDKGQKNGKILHESSTSGQQVLVDRFNGFKSGLAAKCPDAEIIQTSVNDNDLNKAVSQVNDALTATPDLAGVFADNNTSGTGAAKAVAERDASDRVAVVAFDSDPAEIAGVRDGSIDAIIVQNPFFFGYQGVVEAAMAAGDSTPPVRLDPGAVVIDRSTVDEAQYEQLLNPPKTKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7ND76</accession>
    <name>A0A0F7ND76_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH gntR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_34025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_34025"/>
    <dbReference type="EnsemblBacteria" id="AKH86420">
        <property type="protein sequence ID" value="AKH86420"/>
        <property type="gene ID" value="AA958_34025"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_34025"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.7189"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="21"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="78" mass="8107" checksum="7E0C251F746CA6C5" modified="2015-07-22" version="1">MSQPGLDELTPVNPRSTPALVADRLREQIVSGAFVPGSRMTESQLGARLGVSRGQEDFHPGVAAVAVGVDPVAEQVPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDM9</accession>
    <name>A0A0F7NDM9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_28550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018773.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_28550"/>
    <dbReference type="EnsemblBacteria" id="AKH85539">
        <property type="protein sequence ID" value="AKH85539"/>
        <property type="gene ID" value="AA958_28550"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_28550"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6015"/>
    <dbReference type="OrthoDB" id="1583074at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CN hydrolase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="280" mass="31665" checksum="ABA39A1AD834C9B9" modified="2015-07-22" version="1">MANVVRAALVQATWTGDTESMIAKHEEHARAAAARGARIIGFQEVFNAPYFCQVQEPEHYRWAEPVPDGPTVVRMRALARETGMVVVVPVFEIEQEGFYYNTAVVIDADGTVLGKYRKHHIPQVKGFWEKYYFKPGNAGWPVFDTAVGRVGVYICYDRHFPEGWRALGLAGAQLVYNPSATSRGLSAYLWQLEQPAAAVANEYFIAAINRVGVEEYGDNDFYGTSYFVDPRGQFVGDVASDKEEELVVRDLDFGMIEEVRRQWAFYRDRRPDAYGDLVQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDZ6</accession>
    <name>A0A0F7NDZ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RNA polymerase sigma70 factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AA958_12205</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Interacts transiently with the RNA polymerase catalytic core formed by RpoA, RpoB, RpoC and RpoZ (2 alpha, 1 beta, 1 beta' and 1 omega subunit) to form the RNA polymerase holoenzyme that can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86705">
        <property type="protein sequence ID" value="AKH86705"/>
        <property type="gene ID" value="AA958_12205"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_12205"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2567"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014305">
        <property type="entry name" value="RNA_pol_sigma-G_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02960">
        <property type="entry name" value="SigX5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="15"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="7">
        <location>
            <begin position="138"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="SnoaL-like" evidence="8">
        <location>
            <begin position="213"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH86705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="330" mass="36478" checksum="EE974EB1866EADC8" modified="2015-07-22" version="1">MADPAAEEPVEKRLESHRIELTGYCYRMLGSAFEAEDAVQETMVRAWKGFERFEGRASMRSWLYRIATNVCFDMHGSPQRRARPMDLSSPGAATTPPEAALGAALPETTWLEPMPDTKVLPAGGDPAEVAAQRDSVRLAFVAALQHLPPRQRVVLILRDVFAWKASEVAELLETSVASVNSALQRARATLAAEAPADSEPAKPLDADQQRFLERYVDAFERYDLDALTALMREDVILSMPPLPLWLQGPEDIRTWFLGTGSVCRGSRLIPCSANGMPAFAQYHPDPESGGHRGWAIQVLEIEDGKVTHLNSFLGVERLFPLFGLPLVLKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NE31</accession>
    <name>A0A0F7NE31_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_02045</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019723.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_02045"/>
    <dbReference type="EnsemblBacteria" id="AKH86501">
        <property type="protein sequence ID" value="AKH86501"/>
        <property type="gene ID" value="AA958_02045"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_02045"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.441"/>
    <dbReference type="OrthoDB" id="1356861at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH86501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="261" mass="26772" checksum="D1570BDF21312520" modified="2015-07-22" version="1">MSPGANGRNGKSGPLTGAVVAVAGAGGPAGQAALCRLAKAGAVLIGCDADAERLAEAVDAARAAGGGMAQVTGDTVDLLDLHAAHAWAERIEKDYGRVDGLVHLVGGWRGSRSFAATDLADWTVLHDLLLRTVQHTSLAFDEPLRRSDRGRYVLVSAAGASQPTAGNAAYAAAKAGAEAWTLAMADGFRKAGEAEGLDGPAGAAVILVVKALVNDAMRKAKPNAKFAGFTDVDDLADNIAEVWDRPAQELNGTRLWLTAQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NEL0</accession>
    <name>A0A0F7NEL0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_19185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020231.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_19185"/>
    <dbReference type="EnsemblBacteria" id="AKH86895">
        <property type="protein sequence ID" value="AKH86895"/>
        <property type="gene ID" value="AA958_19185"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_19185"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4033"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="SSF50969"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1406"/>
            <end position="1425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="1425" mass="156432" checksum="84E0717DCE6BE81A" modified="2015-07-22" version="1">MASSIVRILTQDGAIVGAGFLIASDTVLTCAHVVSDALGLDRDSPVDLGRQVRLDLPFVPGDTTWTAGVKHWTPVEADQGGDIAVLRLPAPLPGGRPLPMADRREVWDHETRAVGFTRDMSGGDWQKGRFRGPVGSSLVQLSRDNDQAVYVKPGFSGSPVWDDDLGAAVGMVVASQPEQEAQQAFVIRTETLSERVPELRQILLPANPFLGLRRFSEGDEERFFGRDEDISRVVTELKGNHPIVTLCGPSGSGKSSLARAGVVPQLRRSGWDVLIVDCVSTSASTAALATSLFEYAVGGAGGSRSDGIARVRSVDQVDVWLRDVGLVDAFHRATGRPAEHLLVVLDQAEALLSLPDPKLAETLELLFPPRRGGLRILATLRADVINTALNHALLAPVLTSGRTLPLAPMTRGQLHAVITRPLEQAPAVFYDPGLDMRILDDAGTDPGILPLLGFLLKELWDKQHGGQLSAATYQQIGGVKGALVNHAKQVWKQCVSPESEAEARRLLAGLVRVVPGGEATLRRPLTREEAGEERWRLAQEMAMEDKRLLVLYGGNGQAESVELVHEALITEWPELAEVVRDGAAFLNARAEIQHDLERWEQAERRADLLPGGFQLDNLMQRLDGRTDELTQDQREFLHAARRRHRAARKRTRLRWTAGALTLTLIATLTTFGVLQSQVSSQRAAEARSRALAVQSDDLVDTNPSHAALAALAAYEAAPTQEARNALLRRYAEVRDEEWSLSAAEGKFEDAAMSADGKVALVQTEGGRAVLFVRTAQGQVRQESLRLRPRINDPDVSFDGRRISYVRADDGVVVWHNVSFTGQTLVGRGHPLEMPERTAPDAQDRSSSLLQFKETSFSPDGRFLVESGDDAGVFDQPEHPVRVWDLETGRTHELPEKYAIATKAWFGPDNRTMVLEAPSKSMIAVDLRTEKMRRLTEPFEDNPNDSRNEAWVSADGTVALSCRRNPDVEKYSVSYTAIRVADGKVLRSYRDDRGLCGETRLAPSGTRFAREANALNVDWEVLPTSGDARPRKTLGPGPELGGPDLPLLGTADEPVVPVLRDNRLIGQKLTDSEGETAYGRPHLLGDGSTMLVRTRGEGDKLTIVETEGNQRVVSETSVAFKTPPSRDQLFAVNDSQTLMADVSDDTRVTVRRLPSLKKISEFKVAPPPPWAPKDPNPVTLEFLPADRLVTLSGSRVEHWDVADGRRLGGQIDLMDLQPTSRDKREYFISRHRVPGMIGVAVSGKPNVYAVDLRTGRERKNLRISLHDDLLTAEFLKDSRYMAVLTTGRVLELWNAEPGKPPRRVFSQMGPLESGEFTVGNPADAKFFVAYGDTIVFLNLSDPSYRDTYKFGRNQFFEPANTSDGKAFLGSPARDDRDTSIPSGPLKLTRLDPALWEKQVCKVVGRELTDDERDTLPGPLPGRLCPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-12-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NEZ3</accession>
    <name>A0A0F7NEZ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alkaline phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_31730</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019257.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86029">
        <property type="protein sequence ID" value="AKH86029"/>
        <property type="gene ID" value="AA958_31730"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_31730"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6700"/>
    <dbReference type="OrthoDB" id="1629121at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014036">
        <property type="entry name" value="DeoR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018356">
        <property type="entry name" value="Tscrpt_reg_HTH_DeoR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00455">
        <property type="entry name" value="DeoRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08220">
        <property type="entry name" value="HTH_DeoR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00037">
        <property type="entry name" value="HTHLACR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00420">
        <property type="entry name" value="HTH_DEOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00894">
        <property type="entry name" value="HTH_DEOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="4">
        <location>
            <begin position="3"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH86029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="267" mass="27982" checksum="C767D3BCCAD24820" modified="2015-07-22" version="1">MNQHERHGALLRLLAERGRLDVEAAALEVAVSAATIRRDLDQLAEQQLLVRTRGGAVPNDVAYDLPLRHRAGRDAAEKERIGRAAAAMVERGMVVGLNGGTTTAAVARALAARADWGDGEGDGARGDGQPAVTVVTNALNIAAELAVRRSVKVVVSGGVAMPSSYELVGPLAGHILREIRLDIAFVGADAVDAEHGASARDEHEASINALLAAQAATLVVVADSTKLGVRTFARICPPADIDVLVTDDRAADRAREFEEQGMSVVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NF20</accession>
    <name>A0A0F7NF20_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF1524 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_27285</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020452.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_27285"/>
    <dbReference type="EnsemblBacteria" id="AKH87060">
        <property type="protein sequence ID" value="AKH87060"/>
        <property type="gene ID" value="AA958_27285"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_27285"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5749"/>
    <dbReference type="OrthoDB" id="1510738at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011089">
        <property type="entry name" value="DUF1524"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07510">
        <property type="entry name" value="DUF1524"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519439" description="DUF1524 domain-containing protein" evidence="1">
        <location>
            <begin position="37"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1524" evidence="2">
        <location>
            <begin position="119"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH87060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="220" mass="23494" checksum="132E7720DB140E2F" modified="2015-07-22" version="1">MLPGSPAISPRGLIAALALLALALGVALGAAPPAAAFPPDVPPKAQVQAELNSLTVAAEGSMTGYSRDLFPHWTTVSGTCNTRETVLKRDGTNVTTGADCYPTGGSWYSYFDGVTRSSPADISIDHIVALAEAWRSGASSWTTARRQQFANDLTGPQLIAVTTEVNSSKGDRDPADWKPPRTASWCGYAKFWIHTKYRWNLKIDSAEKSAVQSMLNGCSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFD5</accession>
    <name>A0A0F7NFD5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sugar ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_27810</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018641.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_27810"/>
    <dbReference type="EnsemblBacteria" id="AKH85407">
        <property type="protein sequence ID" value="AKH85407"/>
        <property type="gene ID" value="AA958_27810"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_27810"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5862"/>
    <dbReference type="OrthoDB" id="1179151at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
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    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="10"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="42"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH85407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="263" mass="28117" checksum="35015955BC32A550" modified="2015-07-22" version="1">MVHVSATPVLALRGISKRFGAVQALTDVDLEVRAGEVVALVGDNGAGKSTLVKTVAGVHAIDDGRIEWGGRPVRIHKPHDAQDLGIATVYQDLSLCDNLDVVGNLFLGREIRRAGVLDEVEMERRARELLTTLSIRIPSVRIPTASLSGGQRQTVAIARSLLGDPKLVILDEPTAALGVEQTAQVLDLVERLRERDHAVLLISHNMEDVKAVADRVAVLRLGRNNGVFDVATTTQEEIVAAITGATDNAVTRRSARGSAEAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFF3</accession>
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        <submittedName>
            <fullName evidence="3">Xanthine dehydrogenase</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">AA958_32715</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
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            <taxon>Bacteria</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AKH86194.1"/>
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_32715"/>
    <dbReference type="EnsemblBacteria" id="AKH86194">
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    </dbReference>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Ald_Xan_dh_C"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF02738">
        <property type="entry name" value="Ald_Xan_dh_C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01008">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54665">
        <property type="entry name" value="SSF54665"/>
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    </dbReference>
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        <property type="entry name" value="SSF56003"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ald_Xan_dh_C" evidence="2">
        <location>
            <begin position="23"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="528"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH86194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="703" mass="74976" checksum="C774E98919595B95" modified="2015-07-22" version="1">MTTLRPRAVGTPLRRLDGPAKVTGTARYAFEHPLEEPLYVHPVQATVARGRITGVDTEAAAACPGVAVVLTPRDVPRLENTGDEELAVLQSGMIAFRGQLVGAVVAEDVETARHAASLVRIAYEDERPDVELRTDRDDLYAPETVNPFFATDTEDGDVDAAMDRAPVTVDVTYTTPMEHNNPMEPHTTVAVWQPDSAVRLLLYASTQGVHTVGTALAPLFGLEADQVRVISPHVGGGFGSKGMPHAHDVLAALCARAVPGRPVKLALTRQQMFTLAGHRTPTIQHLRLGCGTDGRITAIGHDVVEHTAHIKEFAEQTAVGTRMMYSAAHRRTSHRLAALDVPVPSWMRAPGECPGLFALECAMDELAAACGLDPVELRVRNDPPEDPETGRPWSGRKLVECLREGARRFGWDRRAAAPGARREGRELVGLGVASATYPYNAGQGSEALVRHEGEGRWTVRIGAADIGTGTWTTLTQIAADALDATPDDVMLQIGDTALPPATVAGGSSGLASWGSAVVAAVRAFRERHGDDPAPGAEARAGTPENPDQETYALHSFGAHFAEVRVDADTGEIRVPRMLGVFSAGRIVNPRTARSQFLGGMTMGLSMALHEHTVLDPRTGHVVNNDLADYHIASHADVCDMDAVWLDEEDPHSNPMGTRGIGEIGIVGSPAAVINAVYNATGVRVRDLPATPDKLLAGLDALRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFM6</accession>
    <name>A0A0F7NFM6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_28405</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_28405"/>
    <dbReference type="EnsemblBacteria" id="AKH87086">
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        <property type="gene ID" value="AA958_28405"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_28405"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5986"/>
    <dbReference type="OrthoDB" id="2054097at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029756">
        <property type="entry name" value="MTH1187/YkoF-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89957">
        <property type="entry name" value="SSF89957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH87086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="86" mass="8773" checksum="913F7731A7D8A0F1" modified="2015-07-22" version="1">MEFTTEPFDLEEPPPHAVAARDLVESADLDAVDVGPFGNSAEGGAEVVLDAVDELLRRSLASGATRISLQVSVVGGAPEEPGKAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFW6</accession>
    <name>A0A0F7NFW6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Isoprenyl transferase</fullName>
            <ecNumber evidence="2">2.5.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_32740</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="2">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.-" evidence="2"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_32740"/>
    <dbReference type="EnsemblBacteria" id="AKH87201">
        <property type="protein sequence ID" value="AKH87201"/>
        <property type="gene ID" value="AA958_32740"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_32740"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6917"/>
    <dbReference type="OrthoDB" id="1630604at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00475">
        <property type="entry name" value="Cis_IPPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01139">
        <property type="entry name" value="ISPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001441">
        <property type="entry name" value="UPP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018520">
        <property type="entry name" value="UPP_synth-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036424">
        <property type="entry name" value="UPP_synth-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291">
        <property type="entry name" value="PTHR10291"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Prenyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF64005"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="uppS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01066">
        <property type="entry name" value="UPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2 3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="14"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="58"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="184"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="13"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH87201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="239" mass="27039" checksum="5E8F2F0D8E740EAA" modified="2015-07-22" version="1">MRAGPRHVACVMDGNGRWAQQRSLPRTAGHRAAEAAVIDVIEAARTAGVEWLSLYAFSTENWIRPGTEVEFLMRLVRRVVRTHAPLLLARGIRCRFLGVADPRIPRALARDFYDLAELTAGNRGMTLTVAFDHGGRRDIVEAARSLIRSGTPADEVTERLFADHLPFPDTPNVDLVIRTSGEQRISNFMLWQVAYAEWVFPQVLWPDFRAPDFLAHLHAYRRRDRRFGGVPARTNGDRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NHT6</accession>
    <name>A0A0F7NHT6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_33430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AKH86317">
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        <property type="gene ID" value="AA958_33430"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_33430"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.7060"/>
    <dbReference type="OrthoDB" id="1824834at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH86317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="130" mass="14111" checksum="7A767326880D1C7F" modified="2015-07-22" version="1">MRRSEHVELVDPDAVDDEEGGSYAETSLIFRVLCPDCVQPIALLEGEDVLPEHARVTPANPFGLTVCTGSGSPLSAAVPEDARLDARAEDTAVLLTLPEGLDWRRQPFSHVGGTGNAPVLRRLPGMRRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NID9</accession>
    <name>A0A0F7NID9_9ACTN</name>
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        <submittedName>
            <fullName evidence="8">Glycine/betaine ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_03895</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="444103.AA958_03895"/>
    <dbReference type="EnsemblBacteria" id="AKH86532">
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        <property type="gene ID" value="AA958_03895"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_03895"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.818"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031460">
        <property type="term" value="P:glycine betaine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
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        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
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    </dbReference>
    <dbReference type="InterPro" id="IPR005892">
        <property type="entry name" value="Gly-betaine_transp_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01186">
        <property type="entry name" value="proV"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0129">CBS domain</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="2"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="7">
        <location>
            <begin position="249"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="18"/>
            <end position="25"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH86532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="315" mass="34416" checksum="78EE2CE6FCE16801" modified="2015-07-22" version="1">MVDASFTVESGEIFVVMGLSGSGKSTLLRMLNGLLDATSGRVLFDGQDLTSLTDRELREVRSTKISMVFQHFALFPHRSVLENAAYGLEVQGIPRAEREQRATEALELTGLKGWEHHWPDELSGGMKQRVGLARALATDADLLLMDESFSALDPLIRRDMQDQLIELQSKLKKTIVFITHDLNEAMRLGDRIAVMRDGRIVQIGTPEDILVRPADDYVRRFVEDVDRTRVLTAGSIMEEPQDGLSPKELRAAAPVSVTEDTPVAELFGPFATGDDAVGVTDADGDLVGLVERGRLLSILGDQAGDDEGEKVTAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NIM2</accession>
    <name>A0A0F7NIM2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransf_25 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_08910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_08910"/>
    <dbReference type="EnsemblBacteria" id="AKH86627">
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        <property type="gene ID" value="AA958_08910"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_08910"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1876"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="54"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="270" mass="29753" checksum="150FCC91DBBD927A" modified="2015-07-22" version="1">MGACVSNSEQPAKRYVFDPLWDQETERLLTNEAIWDPGTSERLDRLGVAAGWSVLEVGAGYGGTAERLAELVGPTGRVTAADLETGRLARLKDKGIEVLQVDITTDELPAGQFDLVHSRMLVQHLPDRPAAVRKMVAALKPGGWLFLEDTDSLPLFRSVVSEDFLQDVRAAGYGLMRESGHEPRGGHFDLQAVLECGLEDVSAEGRTVMMQGGSPQARHYQLWLEFMRPRITGAGLLDDARIDAALEEMADPANRWLSQILISTYGRRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NJ19</accession>
    <name>A0A0F7NJ19_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_15480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_15480"/>
    <dbReference type="EnsemblBacteria" id="AKH86797">
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    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_15480"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3257"/>
    <dbReference type="OrthoDB" id="1984437at2"/>
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    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
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    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
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    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="128" mass="13641" checksum="D3E20E35A66BD782" modified="2015-07-22" version="1">MAATAAGSNVAAKRRPGYATFAIAEPPLRLVLIEGEPGEDTRLDHLGVEVETTEQVTAATSRLRDAGLAAFEESGTSCRYALQDKVWVHGPGREPWEVYVVKVDAERLAKEERLTGDAGPRAGSCCGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NJI2</accession>
    <name>A0A0F7NJI2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_21445</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020293.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_21445"/>
    <dbReference type="EnsemblBacteria" id="AKH86942">
        <property type="protein sequence ID" value="AKH86942"/>
        <property type="gene ID" value="AA958_21445"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_21445"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4515"/>
    <dbReference type="OrthoDB" id="1850202at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH86942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="91" mass="10157" checksum="32C92BACD5A9DEC1" modified="2015-07-22" version="1">MALMWEARAAAGRGDELLAWARAQRLPARPLRRETFRAPGDRVLVITWWDADCGNREAPMPELGDPDAGLLARPVHRWRFTSLGPDGPEAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NJY7</accession>
    <name>A0A0F7NJY7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Radical SAM core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_28985</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_28985"/>
    <dbReference type="EnsemblBacteria" id="AKH87097">
        <property type="protein sequence ID" value="AKH87097"/>
        <property type="gene ID" value="AA958_28985"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_28985"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6107"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043365">
        <property type="term" value="F:[formate-C-acetyltransferase]-activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012837">
        <property type="entry name" value="NrdG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034457">
        <property type="entry name" value="Organic_radical-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30352">
        <property type="entry name" value="PTHR30352"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30352:SF2">
        <property type="entry name" value="PTHR30352:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="7">
        <location>
            <begin position="22"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH87097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="190" mass="19600" checksum="AFFCA6CA54425D29" modified="2015-07-22" version="1">MWRVHGVLPRSLANGPGERFVVWSQGCPLACPGCFNPDTHATDGGGTRSVGGLLDAVRAQVPGIEGVTLTGGEPLAQPEAVAAFCAGLRGEPAFGDLGIIVLTGFTRTEIDADPARLAAVAAADLVVAGRYNQSQRLASGLRGSANKEYLYRTGRYRGLDLGGVPEVEVHIGGDGTITGTGMADLRGGDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A097H0W6</accession>
    <name>A0A097H0W6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glucokinase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="1">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">cnq720</name>
        <name evidence="2" type="ORF">AA958_30815</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="ChemBioChem" volume="15" first="2385" last="2392">
            <title>A Membrane-Bound Prenyltransferase Catalyzes the O-Prenylation of 1,6-Dihydroxyphenazine in the Marine Bacterium Streptomyces sp. CNQ-509.</title>
            <authorList>
                <person name="Zeyhle P."/>
                <person name="Bauer J.S."/>
                <person name="Steimle M."/>
                <person name="Leipoldt F."/>
                <person name="Rosch M."/>
                <person name="Kalinowski J."/>
                <person name="Gross H."/>
                <person name="Heide L."/>
            </authorList>
            <dbReference type="PubMed" id="25224759"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CNQ-509</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KJ451627">
        <property type="protein sequence ID" value="AIT42110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019106.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_30815"/>
    <dbReference type="EnsemblBacteria" id="AKH85878">
        <property type="protein sequence ID" value="AKH85878"/>
        <property type="gene ID" value="AA958_30815"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_30815"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6513"/>
    <dbReference type="OrthoDB" id="1130699at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIT42110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="310" mass="29716" checksum="9212687318DC52CE" modified="2015-01-07" version="1">MTVVAALDIGGTKTAAALVGEDGRLLHRRTAPTPAAAGPAAVLDAAAAAVAELTAAGGPYAAVGVGSAGVIDAAAGTVLSATAALPGWAGTALRDELGRRLGVPVAVDNDVHAHALGETWRGAAAGRTHVLLVAAGTGIGGSLVLDGRPLRGARSAAGHLGHLPVPAAAGRPCTCGGTGHAEAVAAGPAMAAEYHRRAGEAAGGDPAGGRGLAVVAERAAAGDTAAVAVLAEGAAALGEAVGGLVNALDPELVLVTGGVSRCGPVWWRPLRAAITTTALPLLSDVPVVPGELGDDAALLGAARLAREAIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MYD3</accession>
    <name>A0A0F7MYD3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Anhydro-N-acetylmuramic acid kinase</fullName>
            <ecNumber evidence="1">2.7.1.170</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">AnhMurNAc kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">anmK</name>
        <name evidence="2" type="ORF">AA958_02530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the specific phosphorylation of 1,6-anhydro-N-acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>1,6-anhydro-N-acetyl-beta-muramate + ATP + H2O = ADP + H(+) + N-acetyl-D-muramate 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:24952"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58690"/>
            <dbReference type="ChEBI" id="CHEBI:58722"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.170"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-sugar metabolism; 1,6-anhydro-N-acetylmuramate degradation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan recycling.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the anhydro-N-acetylmuramic acid kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.170" evidence="1"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014598.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_02530"/>
    <dbReference type="EnsemblBacteria" id="AKH81235">
        <property type="protein sequence ID" value="AKH81235"/>
        <property type="gene ID" value="AA958_02530"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_02530"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.541"/>
    <dbReference type="OrthoDB" id="736294at2"/>
    <dbReference type="UniPathway" id="UPA00343"/>
    <dbReference type="UniPathway" id="UPA00544"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097175">
        <property type="term" value="P:1,6-anhydro-N-acetyl-beta-muramic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006040">
        <property type="term" value="P:amino sugar metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009254">
        <property type="term" value="P:peptidoglycan turnover"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01270">
        <property type="entry name" value="AnhMurNAc_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005338">
        <property type="entry name" value="Anhydro_N_Ac-Mur_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30605">
        <property type="entry name" value="PTHR30605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03702">
        <property type="entry name" value="AnmK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1 2" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="18"/>
            <end position="25"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="399" mass="40904" checksum="E0FF4B8332763960" modified="2015-07-22" version="1">MTHPHPAPALTVVGLLSGTSYDAADAAVCDLRLAGDELLLHPRGLHSAPFPGELRRAVAACLPPAATTMAEVCRLDTELGRFFGRVAAEAVDAVAGGQADLVVSHGQTVYHWVEGRRARGTLQLGGAAWIAEATGLPVVSDVRTRDIARGGQGAPLASTLDALLLLGEGPGPRRGALNLGGIANITVRGGGGVVAYDLGPANALIDAAVADGTGGAETMDTDGARARRGTVDRELLRRLLAEPYYALPAPKSTGKELFHGAYLREQVAAAGARAALDDLVATVTELTAELAAAACREYGVEELVVSGGGVRNPALMARLAELCAPARVSRMEDHGLSSQGKEGYLFALLGFLTVCGLPASVPSATGAREAALLGSVTPGARPLRLPEPAAQAPVRLRVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MYG1</accession>
    <name>A0A0F7MYG1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_02720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014628.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH81265">
        <property type="protein sequence ID" value="AKH81265"/>
        <property type="gene ID" value="AA958_02720"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_02720"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.580"/>
    <dbReference type="OrthoDB" id="2085167at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="62" mass="6905" checksum="7E1CCF74073CE3DC" modified="2015-07-22" version="1">MTTEAAPERHPQPAPRPHPRPRVPEESLTSLDVWARSAPIRLAGYEDDPADTAELHILRGID</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MZR9</accession>
    <name>A0A0F7MZR9_9ACTN</name>
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        <submittedName>
            <fullName evidence="4">RNA helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_05920</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_05920"/>
    <dbReference type="EnsemblBacteria" id="AKH81815">
        <property type="protein sequence ID" value="AKH81815"/>
        <property type="gene ID" value="AA958_05920"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_05920"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1239"/>
    <dbReference type="OrthoDB" id="604268at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010225">
        <property type="entry name" value="HrpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013689">
        <property type="entry name" value="RNA_helicase_ATP-dep_HrpB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08482">
        <property type="entry name" value="HrpB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005496">
        <property type="entry name" value="ATP_hel_hrpB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="21"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="3">
        <location>
            <begin position="222"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="508"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="865"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="508"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="878"/>
            <end position="892"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH81815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="892" mass="94107" checksum="923FCFF7171D222B" modified="2015-07-22" version="1">MALRSDALDALPVRHALPALRAALEEPGVAVLGAPPGTGKTTLVPLALAGLVPGAGDPPRRVLVAEPRRMAARAAARRMAWLLGEETGDRVGFTVRGERRAGPRTRVEVVTTGVLLQRLQRDPELAGVDAVLLDECHERHLDADTALAFLVDVRATLRPELRLVAASATSDTAAWARLLTAPDTAAPAPVVRGEGTMHAVAIGYRPPPAGVRPAHGTRVDPALLAHIADVVREGLRRPDGDVLCFLPGVGEIARVAGLLTDTAADVLQLHGQAPAEVQNAVLRGSAPGERRVILSTAVAESSLTVPGVRIVVDGGLAREPRMDHARGLGALTTVRVSAATATQRLGRAGREGPGLALRCWSEAEDGRLPRYPSPEIAVADLAGFALQAACWGDPDATGLALLDLPPPGALAAARDVLRAVGAVDTAGRPTPRGTRLAGLGLHPRLGRALLDAADEAGPGAAAEAVALLSEEPPRMYGDDLAAAWRRARRGGDAYAPRWRREAQRLRRALRVPAGDRNPANAHRDDEPGAASQAPGAGGGAGPPAEAPAPADDAARRAAPARAPARDGGRPGDDAVAGLVAALAFPERVARGRGDGSYLMASGTRVEAGAESALRGQPWLAVAVADRPVGAAGARLRLGAPLDEATALRAAETLLRTEDEVTWSAERHETVARRVTRLGAVELRARPLPRPDPARLRAARLDGLRREGTGLLRWSEHARALRRRLAFLHGALGDPWPDVSDDALLARAGDWLDDDPHRIDAGRVLQGLLPWARGEAARLDELAPERIEVPSGSRIRVDYEDPQQPVLAVKLQELFGLDRTPRIADGRVPLLVHLLSPAGRPAAVTADLESFWRQGYPAVRAELRGRYPKHPWPGDPATATPTRHTTRRTNAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0D8</accession>
    <name>A0A0F7N0D8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_00290</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH80863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014229.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH80863">
        <property type="protein sequence ID" value="AKH80863"/>
        <property type="gene ID" value="AA958_00290"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_00290"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.69"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045597">
        <property type="entry name" value="DUF6458"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20059">
        <property type="entry name" value="DUF6458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6458" evidence="2">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH80863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="73" mass="7948" checksum="F6E66232860CDF69" modified="2015-07-22" version="1">MGLGGSILLMAAGGILAFATNWDVNGLDVQVMGWIMMLAGFVGLVVISSVQRRRRAVAPPTEAVVEERHRYYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0S2</accession>
    <name>A0A0F7N0S2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LuxR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_00850</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH80954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014320.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH80954">
        <property type="protein sequence ID" value="AKH80954"/>
        <property type="gene ID" value="AA958_00850"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_00850"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.190"/>
    <dbReference type="OrthoDB" id="1687028at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="4"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="151"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH80954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="230" mass="24817" checksum="B8D92DE04D5B05C0" modified="2015-07-22" version="1">MTLRVLLADDQALLRGAFRMLLDTADDITVVGEAADGREAVHLTRELRPDVVVMDIRMPDVDGLTATSEIAADPELRGSRILILTTYETDEYVAQALRAGAGGFIGKGIGAEELVDAVRTIAAGDTLLSPAATRSLVARFLATPDDAPRHHPERLAVLTPREREMVALVATGLSNQEIAERMFLSPFTVRAHVQRAMTKLEARDRAQLVVIAYRTGLVRATPGGDGDRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0Y2</accession>
    <name>A0A0F7N0Y2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_01285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014389.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_01285"/>
    <dbReference type="EnsemblBacteria" id="AKH81024">
        <property type="protein sequence ID" value="AKH81024"/>
        <property type="gene ID" value="AA958_01285"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_01285"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.283"/>
    <dbReference type="OrthoDB" id="1542347at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="152" mass="16481" checksum="8CA25BBD1FEFFC9B" modified="2015-07-22" version="1">MDRLRSGDSWLAFTDGDRDGPRGPQDPLWPLDAPFGAGEDIIEAGTGTIRDAATTHYRLTVDIAAADALLSTGIRVPGGPFRRLRELPTEVWLDDAGLARRIAIQNAAGNRQSWKVTEFWDFGVAGAITPPDADQITTADPADFQRIFMGDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N122</accession>
    <name>A0A0F7N122_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Enoyl-CoA hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_05240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015055.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_05240"/>
    <dbReference type="EnsemblBacteria" id="AKH81701">
        <property type="protein sequence ID" value="AKH81701"/>
        <property type="gene ID" value="AA958_05240"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_05240"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1100"/>
    <dbReference type="OrthoDB" id="1275789at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH81701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="263" mass="27831" checksum="CCF64AC1A90C1832" modified="2015-07-22" version="1">MTELLHRDGVRLALDGEDGTLATVTLDHPARRNAQSPALWRALAAAGRELPGSVRVVVLRAEGKSFSAGLDRQAFTPEGFADEPSFLELAGYSDGDLDAVIAEYQEAFTWWRRNDIVSLAAVQGHAIGAGFQLALACDLRVCADDAQFAMRETSLGLVPDLTGTGPLVQLVGYARALEMCVTGRFVHAAEAERVGLANLVVPAAELGAATADLAAALLAAPRDAVIETKALLREAAGRTYEDQRAAERAAQARRLRDLAGAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N140</accession>
    <name>A0A0F7N140_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Peptidase M20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_08895</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015672.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_08895"/>
    <dbReference type="EnsemblBacteria" id="AKH82325">
        <property type="protein sequence ID" value="AKH82325"/>
        <property type="gene ID" value="AA958_08895"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_08895"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1873"/>
    <dbReference type="OrthoDB" id="906744at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH82325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="431" mass="45027" checksum="953BA6D1E56B0DA1" modified="2015-07-22" version="1">MTTAQVRLSRADRDLLLDLVGLPTAGPMETGPDAEPPRLREAQMRYARAAAELGFEVAYHAAPGPEWLDRPDVPAQVRDMARRVDGFLDSQPSLVLRLGGALPRARTLMFNVHLDTVAGGKPPHLAGDRFHGRGAVDAKGPAVALLAGLRAAITRVPALGTDVGVLIQAVSGEEGGAMGVFGTRPLVEQGWTGRINVFCEPTRGLLVPRATAAATARIAVAGADSIDDHPDAGHNASVLLGFLAQRLARTLPGAVAEGRVCVAGLHTGAAHNKVYGTGALLLNLAYRTAAAGRAQEEALERELSAGIDEFAAVFGGLPDFARTARDARRITRLAWLKRGLPALDNRDAWAEQVLTGAGLEYAPPDAPACTCDAIWAHALPHAHTVVYGPGDLDANGAHAADEYVDASDLERYADGIASMVAAFASATNGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N156</accession>
    <name>A0A0F7N156_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_05495</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015095.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_05495"/>
    <dbReference type="EnsemblBacteria" id="AKH81741">
        <property type="protein sequence ID" value="AKH81741"/>
        <property type="gene ID" value="AA958_05495"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_05495"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1152"/>
    <dbReference type="OrthoDB" id="1911275at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="9"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH81741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="210" mass="22518" checksum="F58D85113DED6878" modified="2015-07-22" version="1">MTFAPGPIPSRTQYVQDAIKHAILTGKLTPGQPLVETDLAAQFGVSKTPVREALKTLAGSGLVVMSQYKGVTVRTVDAAMAREVYDVRLLLEPEALRRTVALEASLLAAEEALVRAESAPDAADRSLANRDFHRALYLPCGNPLLSRMLDDLRDQAALVSTVAWSANPSWEREAGEHREILRLAAAGDAQAAGAALHDHIASFLARAFPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N251</accession>
    <name>A0A0F7N251_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA primase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_07385</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015431.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_07385"/>
    <dbReference type="EnsemblBacteria" id="AKH82081">
        <property type="protein sequence ID" value="AKH82081"/>
        <property type="gene ID" value="AA958_07385"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_07385"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1548"/>
    <dbReference type="OrthoDB" id="1173531at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015330">
        <property type="entry name" value="DNA_primase/pol_bifunc_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09250">
        <property type="entry name" value="Prim-Pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00943">
        <property type="entry name" value="Prim-Pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prim-Pol" evidence="2">
        <location>
            <begin position="40"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH82081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="247" mass="26711" checksum="B358D533671BD7D3" modified="2015-07-22" version="1">MARVRRLPQWLPGTRRGRTRGSAAAAERLQAAAAERRELLLAAADAGLPLAPAAYPEGYGCSCDRIGCPSPGRHPVSFAWQTQASADAQRVERWLAAQPEANFITATGRSHDVLDVPQEAGTRALAQLEAEGVAVGPVAVSPEPPGPGRMLFFTSTRGTPEDEDEWWPCELDCRPETMDEHPGLRWHCRGSYVLVPPARLPGDDGVTWLRGPEHPLPDPLTLLEALTDACAAYAGAEREREAAWPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N299</accession>
    <name>A0A0F7N299_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_01070</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH80992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014358.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH80992">
        <property type="protein sequence ID" value="AKH80992"/>
        <property type="gene ID" value="AA958_01070"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_01070"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.235"/>
    <dbReference type="OrthoDB" id="2047542at2"/>
    <dbReference type="Proteomes" id="UP000034283">
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    </dbReference>
    <dbReference type="GO" id="GO:0003677">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="24"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH80992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="230" mass="25345" checksum="A892C1D3CCECA062" modified="2015-07-22" version="1">MAIDRPSASAGNPAPVRPLRRDAQRNREALLTAARSCFAEQGMEAPLEQVAKRAGVAIGTLYRHFPTRLDLVQATFAEKLAVWREAAEKAVTMDDAWAGLCHFLETMCELQSQDRGFNDLASIRLPESACLAGAQTRIRELGVHIVERAQEQGSLRPDLTPEDLAFVIWSHSRVTEATHAIAPDAWRRHLYLLLDGFRTDRAHPLPAPPLTEEQLYRAMISLGGNGACGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2C8</accession>
    <name>A0A0F7N2C8_9ACTN</name>
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        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_11570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
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    <dbReference type="EnsemblBacteria" id="AKH82765">
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        <property type="gene ID" value="AA958_11570"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_11570"/>
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    <dbReference type="OrthoDB" id="653697at2"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
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    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
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    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="13"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="358" mass="39601" checksum="CCA142B251845872" modified="2015-07-22" version="1">MATVHHWTGLEARALRHALRMSVRAFAQHLGLAVATISKWESKLAATEPRPDTQAILDTALGKADASVHLRFEAILSETTGTMPAGPRAWEYESWADDLDRVVVALSRQNFTFADSLLDRWLGRFSPTELDEKGLYLFARSTALLGDLQRYRGTLGGLLSAQHSYTDARAVFTELGIPRRVAQLDLALAVVMEMSGKLEIAARTYEALAVDDRLSRRDRARARLWVGTALSKDGRHDYATRAMRAATREFEELAEPDDWSMAHQKLALARRGAGDLTAAFRLLDIARTAGAPESPMQRVQLTTAQAHILRTDPATRDDGLRLLDDAAQVAARSGLGHQLRSIEAIKKTCEGAFKPRHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2T4</accession>
    <name>A0A0F7N2T4_9ACTN</name>
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        <recommendedName>
            <fullName evidence="2">HTH_30 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_12525</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016255.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_12525"/>
    <dbReference type="EnsemblBacteria" id="AKH82920">
        <property type="protein sequence ID" value="AKH82920"/>
        <property type="gene ID" value="AA958_12525"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_12525"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2632"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_30" evidence="2">
        <location>
            <begin position="335"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="402"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="413"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH82920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="428" mass="47560" checksum="AD4811AE5E3E4894" modified="2015-07-22" version="1">MPSEVQAVALAEPPEPLPRELAALIRPELPSLYREIVAAIRGAVPEYGLQRGEAYDRALRLGVRQSLNTFTDRVATPRKRAVSLAEVHRRLGRFEAQEGRSLDALQSAYRIGGRVAWRRAMVVGERNHLASHVMNAFADALLAYIDELSELAREGYLQAEADSAERLKSLRRRLLRTLVAEPPVPRHTVEDIAAQARWQLPEEVTPAALMPAERLTSLTGLPEDVLADTAGPHPYLLIPGPFDDERREALDVALGTVGVAVGLTVPLHRTADSLRWARQALGMVESGVIRAPSPVRVEDHLLTLWLLTDPALVEQMAGRQLQPLAAVTTGRRERLVETLRVWLTTRATAGRIAEQLHVHPQTVRYRMRTLGRHFGSQLTEPDRRFALEATLRALWLRDQADLPSTGPVTGRTGRAEHPDRTERTEPPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2X9</accession>
    <name>A0A0F7N2X9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_02360</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014571.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_02360"/>
    <dbReference type="EnsemblBacteria" id="AKH81207">
        <property type="protein sequence ID" value="AKH81207"/>
        <property type="gene ID" value="AA958_02360"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_02360"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.506"/>
    <dbReference type="OrthoDB" id="1438064at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH81207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="204" mass="21955" checksum="5E1A9B141861B67F" modified="2015-07-22" version="1">MDSAPSDRRVDDALALKILIAGGFGVGKTTLVGSVSEIRPLRTEEQLSEVGTAVDDTGGVDEKTTTTVAMDFGRITIRAGLAVYLFGTPGQDRFWFLWDELATGALGAVVLADTRRLQDCFPAVDYFEHRSIPFIVAVNCFPGSRGFGAHEVARALDLDQGTPVVLCDARDRDSGKEVLIRLVEYAGRVHTARLLDTVGTEPVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N348</accession>
    <name>A0A0F7N348_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">UvrABC system protein A</fullName>
            <shortName evidence="13">UvrA protein</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Excinuclease ABC subunit A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">uvrA</name>
        <name evidence="17" type="ORF">AA958_05735</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Forms a heterotetramer with UvrB during the search for lesions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the ABC transporter superfamily. UvrA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015136.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_05735"/>
    <dbReference type="EnsemblBacteria" id="AKH81783">
        <property type="protein sequence ID" value="AKH81783"/>
        <property type="gene ID" value="AA958_05735"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_05735"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1200"/>
    <dbReference type="OrthoDB" id="152379at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009380">
        <property type="term" value="C:excinuclease repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009381">
        <property type="term" value="F:excinuclease ABC activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00205">
        <property type="entry name" value="UvrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004602">
        <property type="entry name" value="UvrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041552">
        <property type="entry name" value="UvrA_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041102">
        <property type="entry name" value="UvrA_inter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17755">
        <property type="entry name" value="UvrA_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17760">
        <property type="entry name" value="UvrA_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00630">
        <property type="entry name" value="uvra"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 13" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 13" id="KW-0228">DNA excision</keyword>
    <keyword evidence="12 13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10 13" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="2 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 13 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0677">Repeat</keyword>
    <keyword evidence="13" id="KW-0742">SOS response</keyword>
    <keyword evidence="8 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ABC transporter" evidence="16">
        <location>
            <begin position="603"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="13">
        <location>
            <begin position="744"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="942"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="942"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="32"/>
            <end position="39"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13 14">
        <location>
            <begin position="645"/>
            <end position="652"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AKH81783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="992" mass="108739" checksum="F214B2F5E3D0E2FE" modified="2015-07-22" version="1">MADRLLVRGAREHNLKNVSLDLPRDSLIVFTGLSGSGKSSLAFDTIFAEGQRRYVESLSSYARQFLGQMDKPDVDFIEGLSPAVSIDQKSTSRNPRSTVGTITEVYDYLRLLFARIGKPHCPVCGRPITRQSPQAIVDKVLALPEGSRFQVLSPLVRERKGEFVDLFSDLQSKGYSRARVDGQTSSLTDPPKLKKQEKHTIEVVVDRLTVKESAKRRLTDSVETALGLSGGMVILDFVDLDADDPDRERMYSEHLYCPYDDLSFEEMEPRSFSFNSPFGACPDCTGIGSRMEVDPELIVPDPDKSLDEGAIHPWSHGHTKDYFARLVGALADDLGFRTDIPWGGLPQRAQKALLQGHRTKIEVRYRNRYGRERSYTTSFEGAVPFVKRRHAEAESDASRERFEGYMREVPCPTCNGTRLKPVVLAVTVQDRSIADISAMSISDCADFLGAMELTDREKTIAERVLKEVNERLRFLVDVGLDYLSLNRAAGTLSGGEAQRIRLATQIGSGLVGVLYVLDEPSIGLHQRDNHRLIETLVRLRDLGNTLIVVEHDEDTIKTSDWVVDIGPGAGEHGGTVVHSGSLKELLDNDASVTGQYLSGKREIPTPEIRRPVDGGRQLVVRGARENNLQDIDVAFPLGVLTAVTGVSGSGKSTLVNDILYTHLARELNGARSVPGRHTRVDGDDLVDKVVHVDQSPIGRTPRSNPATYTGVFDHVRKLFAETTEAKVRGYQPGRFSFNVKGGRCENCSGDGTIKIEMNFLPDVYVPCEVCHGARYNRETLDVHYKGKSIAEVLDMPIEEALSFFEAVPAIARHLRTLNEVGLGYVRLGQPAPTLSGGEAQRVKLSSELQKRSTGRTVYVLDEPTTGLHFEDIKKLIGVLTGLVDKGNTVIVIEHNLDVIKTADWVVDLGPEGGSGGGLVVAEGSPEEVAAVPASHTGKFLREILGDRVSDSPPARRRTTAKKPAKKAAAKTASAKAPAKKAAAKKTAAKRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3A0</accession>
    <name>A0A0F7N3A0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_13825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016464.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_13825"/>
    <dbReference type="EnsemblBacteria" id="AKH83135">
        <property type="protein sequence ID" value="AKH83135"/>
        <property type="gene ID" value="AA958_13825"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_13825"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2911"/>
    <dbReference type="OrthoDB" id="1832160at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HATPase_c" evidence="1">
        <location>
            <begin position="35"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="162" mass="16937" checksum="34B257C8F62A1419" modified="2015-07-22" version="1">MGTEAAAVLAPLWRGLPSLDSGAVDGAASCAISGSHESVSGARAFTHTTLRHWELTDLSDDVALVVSELVTNALRHALTGREGQDPAVRLHLMRWASRLVCAVRDPSTASPVAGVADVGAESGRGLYLVDSFSDGWGWHPLDGPLRGKVVWAVFHLPPPAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3H5</accession>
    <name>A0A0F7N3H5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Amino acid ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AA958_10580</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015937.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_10580"/>
    <dbReference type="EnsemblBacteria" id="AKH82596">
        <property type="protein sequence ID" value="AKH82596"/>
        <property type="gene ID" value="AA958_10580"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_10580"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2227"/>
    <dbReference type="OrthoDB" id="1523519at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010065">
        <property type="entry name" value="AA_ABC_transptr_permease_3TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043429">
        <property type="entry name" value="ArtM/GltK/GlnP/TcyL/YhdX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014342">
        <property type="entry name" value="Ectoine_EhuC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30614">
        <property type="entry name" value="PTHR30614"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03004">
        <property type="entry name" value="ectoine_ehuC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01726">
        <property type="entry name" value="HEQRo_perm_3TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="8">
        <location>
            <begin position="15"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="218"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH82596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="248" mass="27609" checksum="4259D2C4DC7E0AC0" modified="2015-07-22" version="1">MMSWEFFREWFLPGIWITIQVLVYSAVLSAVVAFVIGTLRTSRFWIVRFLAGAYFEIFRGMSALIFMFWMAFAVPLMLGWQFVPLWSGTLALGLTYGAYGSEIVRGALAAVPAAQREAGIALSFTRWQRLRRIELPQAFPEMVPPFNNLLIELLKGTSLVSVIAVADMTFAGNLLRLAKNESAPIYTLLLVLYFILAFILTRLMRMLERRAKAGVGRAPEKRNGLLSRKLSPSGESMQASTQGAGGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N401</accession>
    <name>A0A0F7N401_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_11430</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LytR/CpsA/Psr (LCP) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016077.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH82741">
        <property type="protein sequence ID" value="AKH82741"/>
        <property type="gene ID" value="AA958_11430"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_11430"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2405"/>
    <dbReference type="OrthoDB" id="491753at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027381">
        <property type="entry name" value="LytR/CpsA/Psr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004474">
        <property type="entry name" value="LytR_CpsA_psr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13399">
        <property type="entry name" value="LytR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03816">
        <property type="entry name" value="LytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00350">
        <property type="entry name" value="lytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="LytR_cpsA_psr" evidence="4">
        <location>
            <begin position="175"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="LytR_C" evidence="5">
        <location>
            <begin position="440"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="532"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH82741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="581" mass="62285" checksum="574E75D2072AE8B7" modified="2015-07-22" version="1">MRRSNVRGSGADGRPDRAGELGWDDSLYEDAGAPGMPRQRGYARHTGDHDPHDDDGREGPGPGAHPGSHAEGPGDGGPPPPRRRRGMRIARWFFGIVAFLILGTAAAGYLYYRDLNNNLEKDRLNLGKNKLDEKQPNADGQTPLDILLLGSDSRNSDENVRLGGSRADRGRKPLADVQMLLHVSADRSNMSVVSVPRDTRVTIPECTDPDDGTVYPETTSQTINTSLQNGGPGCTVAAWEALTGVSIDHFMMIDFAGVVSMADAVGGVPVCVRDNVYDDDSGLRLEEGETTIKGEQALQWLRTRHGFEDGSDIGRTHAQHQYMNSMARQLKEGAKLSDPGKLRRLAEAATNALTVDDGLGDLKKLYDLGNDIKRVPPERITMTTMPWVPDPQNNAHVVPNEEDAPQIWSMIRNDVAFDGKDKPKKKKPDDLVAQAEPKADIPVLVQNGTGTTMYAPVTGRAGDIAGVLAEDGFTQAATDATPKSQADTTVSYATEEQHANALAVAKALGLPDRAVKESSGVDGVTLVVGADWREGNAYPPDAGGDADDGEEAGPEKAPESSNPLAGSDKKACMDVNPSYTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4B4</accession>
    <name>A0A0F7N4B4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_08245</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015573.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_08245"/>
    <dbReference type="EnsemblBacteria" id="AKH82223">
        <property type="protein sequence ID" value="AKH82223"/>
        <property type="gene ID" value="AA958_08245"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_08245"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1739"/>
    <dbReference type="OrthoDB" id="121040at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021345">
        <property type="entry name" value="DUF2961"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11175">
        <property type="entry name" value="DUF2961"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519226" evidence="2">
        <location>
            <begin position="30"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="693"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="821"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="693"/>
            <end position="710"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH82223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="842" mass="89436" checksum="85C0F053164A144F" modified="2015-07-22" version="1">MDRHGRIRGGTAALLAVVTALATGGLAAAAPEAPEPRGGPDRAAAKGPVGWDTYRQLDRLSDLPAGVHTKQFSSFDRTGGNAHDGFDGKYSCLRTTPAGCVIAEQAGAGEIGAIWFTRDEGDVSRTGRITVELDGEKVVDATLQDLVDGKLGAPFVSPLVANADQTSGGVVIEVPMPYRESMRITTEHNPLFHHVSYRTFADAEGVTTFDPDDPAADVVAALRAAGTADPKPVVPGARTQRTGLSLAPGASQTLARADRPGLLTELRLKLPQAPYVQPRSETDDGRAYGAGGGSEFTLAIDPGNEGVRLTRRYDPIIANQVATVYVDGREAGTWGPTPQAGGGLWGEDSVELPAELTAGKSEITVRNAFVSSDLDVNEFTYWADSRVGGETRRTDTMDVGDAASETAHGYAITAPNWHGVRTYDYPLGDGERAELAAAQDVLRGLRLRATFDGERTVDAPLGEFFGSGHATAPVRALMYGIDAEAAGGPVLTSWWPMPFARNAKVELYNGSGTAVTSGTAEVTAAPSRTHAQAVASGDAGRFRATSHAGPTVPGESWDFLATAGTGKFTGVTHTMTGELNRNYLEGDERVYVDGARTPQIHGTGTEDFYQSGWYFNRGTYAQPFNGNPAHLGPPTGCAADRDCTGTYRLMIHDAVPFTQAIDFDIEHGFVNDKQADYSSTAYWYGEKKATGAKTDTLDVGDPESEEAHGYTSDAPGDVTGLDSVFEGDAQKPLRLTADVRATTAPVSFTLRVDRGNAGVELRRTSDQAAPYQRAAVRVDGKRLPDWLQPLGNAERRWLDDTYQIPASVTAGKREITVTLTPAADAPPWSAESYEAHSLRDGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4C1</accession>
    <name>A0A0F7N4C1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_08300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015583.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_08300"/>
    <dbReference type="EnsemblBacteria" id="AKH82233">
        <property type="protein sequence ID" value="AKH82233"/>
        <property type="gene ID" value="AA958_08300"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_08300"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1751"/>
    <dbReference type="OrthoDB" id="957193at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="52"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="263" mass="27577" checksum="4B6ECD8E1C30B55D" modified="2015-07-22" version="1">MSRAGAPASLREFYENPAVPVASGDARSRRQARMLADALGPFRTGAAPAVVVDVGCGDGSAAAVAAGVLDARRPGGQRIVAVDWSHDALRRARTRTRDAAAGTPVHVVRGGLPDGAAQPAGLPFAAGSADAVLFSEVVEHLVDPDAALDELRRVLRPGGHLLLSTPNLAAWYNRALLLAGVQPVFSEVSLRGIHGRPGSQVVGHLRLYTARALRGFLAASGFTVEKVAGAPYHDVPRPLRPFDRALCRAPSLASILLVHARRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4D5</accession>
    <name>A0A0F7N4D5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="5">PPIase</shortName>
            <ecNumber evidence="5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_16325</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 5">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="5"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016820.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_16325"/>
    <dbReference type="EnsemblBacteria" id="AKH83515">
        <property type="protein sequence ID" value="AKH83515"/>
        <property type="gene ID" value="AA958_16325"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_16325"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3439"/>
    <dbReference type="OrthoDB" id="1861282at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000413">
        <property type="term" value="P:protein peptidyl-prolyl isomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PTHR45625"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="SSF50891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="6">
        <location>
            <begin position="11"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH83515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="174" mass="18959" checksum="AB49E71965EE5DA4" modified="2015-07-22" version="1">MAEQLYATLKTNHGDIEVKLLPNHAPKTVQNFVGLATGEREWTHPATGQVSHERLYDGTVFHRVISGFMIQGGDPLGNGTGGPGYEFGDEFHPDLAFDRPYLLAMANAGPGTNGSQFFITVAPTAWLTGKHTIFGEVADEAGKKVVDEIAAVRTKRADRPEKDVVIESVEITRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4J2</accession>
    <name>A0A0F7N4J2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Antibiotic transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_05670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015126.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_05670"/>
    <dbReference type="EnsemblBacteria" id="AKH81772">
        <property type="protein sequence ID" value="AKH81772"/>
        <property type="gene ID" value="AA958_05670"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_05670"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1187"/>
    <dbReference type="OrthoDB" id="498436at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010290">
        <property type="entry name" value="TM_effector"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05977">
        <property type="entry name" value="MFS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="295"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="319"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="360"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="385"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="408" mass="40979" checksum="D7F5F43D0BA79CD2" modified="2015-07-22" version="1">MRSGTTHPRQTAAPAWRGGFGRLWAAAAVSRFGDALRGAALPLLAVELTDSALLVALVTACGFLPWLLFGLIGGALADRVDQRRAMWITDVLRGLLMAAFALAVWQERAGIALLLVLAFALTALQTVFDNAATALLPAVVPAAALGTANGRLLAGQEAVHRFAGTPLVPVLVGAGAAVPYAVDAVSYLLAAALVAGLPRRRRPAAERPPTPLRRDVADGLRALWTEPVLRGVCAATVVANTGFGALVATLVLHLTGWLGAGTTGYALALTAYGIGSVSGGMAAGRIAAALGAPRTLVWAGLAQAACLTAFGTVRSLPAAGAALAVLGFAGMLWTATEITVLQRRSPAGAIGRTSAAFRTLSISVVPLGAVLGGVLAGSLGENTPALAAAVLTGLGVAALGPAARSGIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4Y5</accession>
    <name>A0A0F7N4Y5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MDMPI_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_06195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015220.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_06195"/>
    <dbReference type="EnsemblBacteria" id="AKH81867">
        <property type="protein sequence ID" value="AKH81867"/>
        <property type="gene ID" value="AA958_06195"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_06195"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1294"/>
    <dbReference type="OrthoDB" id="1914615at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017517">
        <property type="entry name" value="CHP03083_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017519">
        <property type="entry name" value="CHP03085"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024344">
        <property type="entry name" value="MDMPI_metal-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11716">
        <property type="entry name" value="MDMPI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03083">
        <property type="entry name" value="TIGR03083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03085">
        <property type="entry name" value="TIGR03085"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MDMPI_N" evidence="1">
        <location>
            <begin position="12"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="210" mass="23251" checksum="FA92FFB907860786" modified="2015-07-22" version="1">MTTHAKRERLLLADLLEGAGSEAPTLCEGWTTYDLAAHVVVRERRQDAAGGILFKPLQNRLERVQAEFRQKSYEELVQLIRSGPPRFSPFALKQVDEAANVVEFYVHAEDVRRAQPDYAPRELDPVFSDTLWNRLERGAKMMGRKSPVGLVLRRPDGQTAVAHRGAPVVTVTGEPAELLLFATGRQEAAKVELEGDEDAVAQARSAPLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N504</accession>
    <name>A0A0F7N504_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_06335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015240.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_06335"/>
    <dbReference type="EnsemblBacteria" id="AKH81887">
        <property type="protein sequence ID" value="AKH81887"/>
        <property type="gene ID" value="AA958_06335"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_06335"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1323"/>
    <dbReference type="OrthoDB" id="1757088at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="162"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="280" mass="31372" checksum="D637A42C3614C005" modified="2015-07-22" version="1">MEYVGIVPAPPLDRFIDDIYCLTGVPRHRLMNVPPMPSAHLFLHHGGPVRLWDSDRSVPPALMTDGWFMGVWTRRFLFAYPPRVRLVGVHFKPWGMSPFAGLPAAELRNRWAPLDAVWQRSADRIRNRIGDAASAAEALRVVEEELRSHLAVAPARGLDLVRHTGGWLETSHGTVAVRALADAAGVSGNHLAGLFKDHVGVTPKRMARIYRFARLIVSVDALRPVDWSGLAQTAGYFDHAHFSREFKDFTGHTPTEYLALRRRFPAERRDPQDLGPMPAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N559</accession>
    <name>A0A0F7N559_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ATP/GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_17975</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017082.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_17975"/>
    <dbReference type="EnsemblBacteria" id="AKH83780">
        <property type="protein sequence ID" value="AKH83780"/>
        <property type="gene ID" value="AA958_17975"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_17975"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3781"/>
    <dbReference type="OrthoDB" id="260566at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH83780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="457" mass="49576" checksum="95150833DF082672" modified="2015-07-22" version="1">MADLLDLATRAFAGFVFGKTETQRLPVRTSSAQAQAVYLPTAAPGLGDSGVIIGREVYSGKGYIYDPFQLYGQQLPAPHWLVLGESGNGKSALEKTYVLRQLRFRDRQVVVLDAQGEDGVGEWALIAQELGITPIRLDPLAALDSGIRLNPLDPAITTTGQLALLRTIIEVATGSGLDERSGFALKVAHGHVTATVTDRQPVLTDIVEQLRHPAPTAAEAMNVDVEDVRNWGLDVALVLDRLVDGDLRGMFDGPTTVGIDLDSPLIIFDLSHIDRNSIAMPILMAIVGVWLEHTWIRPDRKKRIFLVEEAWHIINSPFVAQLFQRLLKFGRRLGLSFVAVVHHLSDVVDGAAAREAAAILKMASTRTIYAQKADEARATGKVLGLPRWAVEIIPTLTPGIAVWDVNGNVQVVKHLVTEAERPLVFTDRAMTESAPVPALEAADDTGPVVMAKESTVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5H8</accession>
    <name>A0A0F7N5H8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AA958_07315</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial sugar transferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_07315"/>
    <dbReference type="EnsemblBacteria" id="AKH82067">
        <property type="protein sequence ID" value="AKH82067"/>
        <property type="gene ID" value="AA958_07315"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_07315"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1532"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003362">
        <property type="entry name" value="Bact_transf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017475">
        <property type="entry name" value="EPS_sugar_tfrase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02397">
        <property type="entry name" value="Bac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03025">
        <property type="entry name" value="EPS_sugtrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="113"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="294"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_transf" evidence="8">
        <location>
            <begin position="288"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH82067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="482" mass="51712" checksum="5257AAF984FDA8DF" modified="2015-07-22" version="1">MTAEPRRGTRVRSAAAKPAWYLPAALVTDAAGIAIPVVLVFLTTRQPYPAHCAALAAGGWLAVRAARRRYSARQLGESGAVVPLLQDWLLLFGVLAVVRAFTADSAAEPQPALLALLPALVLTVVTAKLLHHHLVASRREGQAVRRVLVVAEPATADHVVGRLAARTDHEYVVVGVVPVGEAPLSCGAPEAARLGPVPSDRAGWDAQAVLAAAREHGAELVLAAPGPLLPAARLRQLAWALHDAGLPLAVLPGIAEVAERRLRLSVVAGLTLLHIAPPLRRGAQSTLKALSDRVAAAIGIVLLAPVFAVIAAAVRFTSPGPVFHRQTRLGRGGAPFTMWKFRSMVEDAEQQKAALSVVNDHDGSPIFKIRRDPRVTRVGEVLRRSSLDELPQLFNVLRGEMSLVGPRPPLPEEVARYSDTELRRLAVKPGMTGLWQVSGRSDLTWDETIALDLHYVENWSFAHDMDVMARTLRAVVDGRGAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5I2</accession>
    <name>A0A0F7N5I2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RNA polymerase sigma factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AA958_10975</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016002.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_10975"/>
    <dbReference type="EnsemblBacteria" id="AKH82664">
        <property type="protein sequence ID" value="AKH82664"/>
        <property type="gene ID" value="AA958_10975"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_10975"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2310"/>
    <dbReference type="OrthoDB" id="1914729at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000838">
        <property type="entry name" value="RNA_pol_sigma70_ECF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01063">
        <property type="entry name" value="SIGMA70_ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="5 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="8">
        <location>
            <begin position="24"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4" evidence="9">
        <location>
            <begin position="124"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AKH82664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="182" mass="20292" checksum="AEF512AEA4E89276" modified="2015-07-22" version="1">MRDDAVVAAQRSKPTPDEELMRVLYREHAGPLFGFVLRLVAGDRHRAEDVVQETLLRAWRHADELAAADGSVRPWLVTVARRIVIDGHRSRQARPRETDPAPLESLPAADDTDRVLRLMTISEALDDLTPAHRAALVETYFKGRTANEAAEVLGVPAGTVRSRVFYALRSLRLSLEERGVVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5V5</accession>
    <name>A0A0F7N5V5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Carbon starvation protein CstA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AA958_11925</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptide transporter carbon starvation (CstA) (TC 2.A.114) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016159.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_11925"/>
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</entry>
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            <authorList>
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                <person name="Albersmeier A."/>
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                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">CNQ-509</strain>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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    </evidence>
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</entry>
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                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
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            <text>a quinol + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) = a quinone + reduced coenzyme F420-(gamma-L-Glu)(n)</text>
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    </dbReference>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="322" mass="34327" checksum="CF9166C786D56734" modified="2015-07-22" version="1">MTTEQQQPPSPAEFNRLVIEEFRANGGRVGGMFEGAPLVLLTTTGARSGTRRTNPVVYLRDGARLLVFGSNGGADHHPAWYHNLLAHPRVTVEIRDADAPGGTTAYEADAVPLPAAERDRMYAVQAGLDPAFAAYERATARTIPVVALHPAPDPAADSDPNPFADPERRLAAGEQLLKAHEELRRELAGVLAAAEGASADTARDPALRDLRRHCLAYCGSLEEHHGAEDGALGAMERQFPRLAPAVARIREEHRDVTAMLERVRDLAAAAPQAAAAPAAAPVRAELHALAARLDAHFAYEERELLPALGLPAPPTRAVTAGP</sequence>
</entry>
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                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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    </dbReference>
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH83791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="65" mass="7185" checksum="758F579108C5F0E1" modified="2015-07-22" version="1">MGRGSAVQDHVALAEIELCGELIIAATSAPEERLSDDRIDEVLRVEAERRGSGLERRRGRQEITP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6Z0</accession>
    <name>A0A0F7N6Z0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_13910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
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            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <sequence length="256" mass="27655" checksum="C8C357C0378A25BF" modified="2015-07-22" version="1">MVREHKDGGPTLTFAEPLPTSGEGSAASAVGQLVHGIRRLWPLVRPLSAEAVVGCLDRETGYPDIGVQPLRPHWFIHDRAAARPTDGRALDVVGPWPVDPVVEPVPDLSAAAIESWLARAQAQASPAPGTHDVGWTDLWFNATRALVPGPYAPDATAHVALDVAEARWVAHVPLRWREGTAWVAGPTREMRQLGARAPITLHASDYGRVELAVSANWSLWSEDGSPGRTVLIDVARDLVADGWCVTYGTEFFHELA</sequence>
</entry>
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    <accession>A0A0F7N705</accession>
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            <authorList>
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="430" mass="46288" checksum="2CD92C973D48C82C" modified="2015-07-22" version="1">MDRPAAEGPGGFAYTDADAEKRRGVRRMKTIATGLLLLAAVVFTLARWAQHNGAGAWSGYVAAAAEAGMVGALADWFAVTALFKRPLGLPIPHTAIIPTKKDQLGQSLGDFVGENFLSADVVRARLHALGLGSRVGGWLAEPDNADRVTAEASTVLRGALTVLRDNDVQAVVGEAINRRAAALEVGPGLGKLLERIVADDGHRRVVDLICERAESWLILNGPSVVGAVTGGAPGWTPRFVDRRVGERVYKELLRFIGEMRESPDHPARGALDRFLSDFAADLQGDTATRARVERLKGELLARDELQDFIAAAWTSLRGMIVGAAEDERSELRLRARAALLSFGQRMAADERLQAKVDGWAEDVATHVVTTYQHQITSLISDTVAGWDADQTSRKIEANIGRDLQFIRINGTVVGSLAGLVIYTVYRAVAG</sequence>
</entry>
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                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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    <dbReference type="EnsemblBacteria" id="AKH84425">
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    </evidence>
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        <source>
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        <source>
            <dbReference type="EMBL" id="AKH84425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="114" mass="12742" checksum="5A128F23780BC2D6" modified="2015-07-22" version="1">MWSWVAHRVTGVLIFFFLFVHVLDTSLVRVSPEAYDDVVATYKTPIVSLLEYGLVAAVLFHALNGLRVIAVDFWSKGPRLQKPMLWIVVGIWAVLMAGAIYPVLGHTARELFGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N789</accession>
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                <person name="Winkler A."/>
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                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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    </reference>
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    <feature type="compositionally biased region" description="Pro residues" evidence="1">
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            <begin position="169"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="EMBL" id="AKH83926.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="195" mass="21194" checksum="CC5397EA61C90DEF" modified="2015-07-22" version="1">MATRSFIARPTDTGYAGVYVHYDGYPSARLPLLLTSCRYRFHGDVEALAGYLIDDLPDSAYGWVELGAGLLRGAPEELRHALTGGVEYPSRTLDNVIDTGGAPAAGRLVTPSTTGGLDWGYVLHPHGIEVINLHTEDRHRGPIVDWRTDPRTAFSDFHRLWKPGRPPAVRTRPASPPVATTPAGPHPAGQRTSRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7G9</accession>
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        <name evidence="4" type="ORF">AA958_15165</name>
    </gene>
    <organism evidence="4 5">
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        <lineage>
            <taxon>Bacteria</taxon>
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        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1 2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Clp R" evidence="3">
        <location>
            <begin position="98"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH83334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="246" mass="25834" checksum="E0D49CBE0BAB45D0" modified="2015-07-22" version="1">MTEPDRSTHPVRLDDLIEAIKKVHPDVLDQLTGAVVAADHLGDVADHLIGHFVDQARRSGASWTDIGKSMGVTRQAAQKRFVTKGSDEGLTLDPSEGFARFTPRAKNVVMASQSEARAAGNTEIGPAHLVLGLLAEPDAVGGAAIKAQGILLDTVRQEAAAALPPAAEGTVPELIPYNAEGKKALELTFREALRLGHNYIGTEHILLALLEQENGDGVLSRLGVDRAAAEAHIAATLAPYQQGGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7N1</accession>
    <name>A0A0F7N7N1_9ACTN</name>
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        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_15550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH83389">
        <property type="protein sequence ID" value="AKH83389"/>
        <property type="gene ID" value="AA958_15550"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_15550"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3273"/>
    <dbReference type="OrthoDB" id="2075110at2"/>
    <dbReference type="Proteomes" id="UP000034283">
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    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="171" mass="18539" checksum="79CB447C92D1677C" modified="2015-07-22" version="1">MSDFRTAALFAAVLTTGLSAGLFYVWSYSVMPGLARASDRTFAESFQQMNRAMMNGWFALTFGGALVLLLLAGGLLLGADGDQRSKPLPWLVAALVLYVAMLAITFAINVPMNNELDAAGAVDQIKDLAGLRERVEDRWVRWNNVRSVVTVLSFGSVSWALLQYGRATGKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7X8</accession>
    <name>A0A0F7N7X8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Rhomboid family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_16320</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016819.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_16320"/>
    <dbReference type="EnsemblBacteria" id="AKH83514">
        <property type="protein sequence ID" value="AKH83514"/>
        <property type="gene ID" value="AA958_16320"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_16320"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3438"/>
    <dbReference type="OrthoDB" id="2053476at2"/>
    <dbReference type="Proteomes" id="UP000034283">
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    </dbReference>
    <dbReference type="GO" id="GO:0016021">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="SSF144091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="228"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="279"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="Rhomboid" evidence="7">
        <location>
            <begin position="132"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH83514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="299" mass="31309" checksum="7C005C9945615462" modified="2015-07-22" version="1">MTDQAPGGAERPAGDSGLPGCYRHPDRETGVRCVRCDRPICPECMISASVGFQCPECVRGGSGTGAAPGASAPRTLAGGVMSEDPRLITKIILGLNLAVFLAVLTGGDRVSDPMLLVGKAIFSFGGSLEGVAEGQYYRLLSSVFLHEEVAHIALNMLALWFLGPPLEAALGRLRFVTLYVLSGLGGSALFYLVAAPNDAALGASGAIFGLFGATAVLMRRMNYDMRPVLVLLAINLVFTFTWSGIAWQGHIGGLVIGTAVAYGFVHAPRDKRVLVQRAVAAAALLAIVAVVVIRTLQLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N800</accession>
    <name>A0A0F7N800_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_12535</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016257.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_12535"/>
    <dbReference type="EnsemblBacteria" id="AKH82922">
        <property type="protein sequence ID" value="AKH82922"/>
        <property type="gene ID" value="AA958_12535"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_12535"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2634"/>
    <dbReference type="OrthoDB" id="1437290at2"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041490">
        <property type="entry name" value="KstR2_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17932">
        <property type="entry name" value="TetR_C_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="12"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="4">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH82922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="224" mass="24645" checksum="050D95381E8BEE1C" modified="2015-07-22" version="1">MTEKRRRRLPRQVREQQIIDVAVRVFSKRGYHAASVDEIAELAGISKPMVYLYLESKEGLFIACLRREAERLVAAFQGAADGVLTPELRLRAGLRAFFSFVSEHRDGWVVLHRHAAELSEAIAAESAGARRAVMAEVTALVRTGIEENGGPVRLGDEDAEFVAHTIVGAADALTDWMAEHPAESPEGMTRRLMNMIWVGMRNVLDGETWAPPPPPPPEPSAAQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8C0</accession>
    <name>A0A0F7N8C0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_17535</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017012.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_17535"/>
    <dbReference type="EnsemblBacteria" id="AKH83708">
        <property type="protein sequence ID" value="AKH83708"/>
        <property type="gene ID" value="AA958_17535"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_17535"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3690"/>
    <dbReference type="OrthoDB" id="1200451at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="12"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="49"/>
            <end position="56"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH83708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="353" mass="37331" checksum="77E68B088874C31E" modified="2015-07-22" version="1">MTPTPPAPAHGLRMSGITVTHPGQRGRRATVLDGLDLDVGDGRLLALLGPSGCGKTTTVQVISGLLRPDHGTVHVGGHDITRTPPERRGAAVVFQQPMLLPHRTALDNVALPVRLRGQHRRAARTAAHDELARVGVADLAGRYPRQLSGGQAQRVALARALAARPRVLLLDEPFSALDTGLRHEMRELLASVQRQLRLTTVLVTHDRSEAAAVADTVAILHGGRLLQHAPAADLHARPASRTVAHFLGAPTALPGTATGHFTCALGRLKLPDHVHHRGPGYLVIRPETVTLGDGPDAVPATVGTVRPDGAFTALRAETNAGPVHALLPPGPPPAVGEQIRLRLPVEHRWVVPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8D8</accession>
    <name>A0A0F7N8D8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNA polymerase sigma24 factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_24340</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Interacts transiently with the RNA polymerase catalytic core formed by RpoA, RpoB, RpoC and RpoZ (2 alpha, 1 beta, 1 beta' and 1 omega subunit) to form the RNA polymerase holoenzyme that can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018072.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH84820">
        <property type="protein sequence ID" value="AKH84820"/>
        <property type="gene ID" value="AA958_24340"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_24340"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5129"/>
    <dbReference type="OrthoDB" id="1335404at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="23"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="7">
        <location>
            <begin position="130"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH84820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="310" mass="33509" checksum="E2D4B0490E2605B1" modified="2015-07-22" version="1">MTTESGPGVAAPDPGLGVIMGERRQMINLAYRLLGSLSDAEDAVQEAYARWYAMPRAEQEAIESPGAWLTTVTSRICLNLLNSARVRRETYVGQWIPEPLPEHTEWTTARGGGSHMDPADRITLDESVSMAFLVMLESMTPAERVAFVLHDVFRYSFAEVAEIVGRSPGACRQLASSARRRIRPSRTPATAPARKAGIVREFRQVWEAQDIDALIGLLDPNATVTADGGGLAAAVTHPVTGAREIALACAGLAARSPLTILERTVNGQPGLVSERNGETVAVLAFDIGGDRITRIWAVLNPEKLRAWNTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8L9</accession>
    <name>A0A0F7N8L9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_18135</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017109.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH83809">
        <property type="protein sequence ID" value="AKH83809"/>
        <property type="gene ID" value="AA958_18135"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_18135"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3813"/>
    <dbReference type="OrthoDB" id="1927273at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519311" evidence="2">
        <location>
            <begin position="29"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH83809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="214" mass="23052" checksum="A694D24C128D9F3F" modified="2015-07-22" version="1">MKRHPLPAAAATAAALALFLAACGGSETDSNEDEKVTGANSAKPSPSPSETEAARPEIKLPDDAKNVFEDWGSSDPEKDAVLRDSAQMIDSIDDAIFKGTTETEALDFYLVGAARQNATDYIKGYLDESHAWAGTTRFTVREVSKRDDGATVVIYCSDESDSYITNVKTGKPIKDSSGGSSAYVLYNTRYEKNKLGVWQMTDGISERGAEQCES</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8N2</accession>
    <name>A0A0F7N8N2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LuxR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_18200</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017119.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH83819">
        <property type="protein sequence ID" value="AKH83819"/>
        <property type="gene ID" value="AA958_18200"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_18200"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3826"/>
    <dbReference type="OrthoDB" id="1687028at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="4"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="153"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH83819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="224" mass="24058" checksum="84EB2F94BF3CD54A" modified="2015-07-22" version="1">MTIRVMLVDDQALLRTGFRMVLAAQPDMDVVAEAGDGDEAVQLLAVTKVDVVLMDVRMPRLDGVEATRRICADKPAEAPPKVLILTTFDLDEYAFSALQAGASGFMLKDVPPGDLLSAIRAVHSGDAVVAPSTTRRLIDRFTAVMPAPAGERAHPELKRLTGREREVLLLIAQGLSNGEIAAQLVLSEATVKTHVGRILTKLELRDRVQAVVLAYETGLVRAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8Q1</accession>
    <name>A0A0F7N8Q1_9ACTN</name>
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        <submittedName>
            <fullName evidence="2">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_13700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016442.1">
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_13700"/>
    <dbReference type="EnsemblBacteria" id="AKH83112">
        <property type="protein sequence ID" value="AKH83112"/>
        <property type="gene ID" value="AA958_13700"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_13700"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2884"/>
    <dbReference type="OrthoDB" id="1865763at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="227" mass="24272" checksum="53115F17A60BD3E0" modified="2015-07-22" version="1">MSSPGAGRPTPPVPTARSSPPADRPPRPPGPRAPDGGPAQASQAARAAATAPAGGGATAVLAAAGPATPPAPLDSLGLPELRRLRRSAQQEEADLSYVRRLLHGRIDILRAELGRRASPHSPVLDRLPEILTDGPSPRPASARHVTLGTPLREEYRELAEEMLAEVALSDLSARTDEELHRGLARLAGYEARISRRRQRLQRTADECCAEIARRYREGEAQVDDLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8Y0</accession>
    <name>A0A0F7N8Y0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_19250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017263.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH83968">
        <property type="protein sequence ID" value="AKH83968"/>
        <property type="gene ID" value="AA958_19250"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_19250"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4049"/>
    <dbReference type="OrthoDB" id="2190377at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH83968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="150" mass="16107" checksum="7016C882717E53F9" modified="2015-07-22" version="1">MADPMAPEDVLRACAYMEAVWRTDTAAMAALLQHEPAEVPTATLLTELGENIMQWIFPAQFGIRGGLTAEELDAAAGKMDADPTVRVSRVLLETLKTLASDGTPENTETIARAVTGFLVAISDAATESDVMTMFDNLRQSALHGFGPRPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9F5</accession>
    <name>A0A0F7N9F5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_20410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH84158">
        <property type="protein sequence ID" value="AKH84158"/>
        <property type="gene ID" value="AA958_20410"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_20410"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4301"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046036">
        <property type="entry name" value="DUF5994"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19457">
        <property type="entry name" value="DUF5994"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="193" mass="20822" checksum="F901CAA24FD0EAC0" modified="2015-07-22" version="1">MTATTIPPPATEDHFTPPPPRLSLTPAGTTPTRLDGAWWPRSRDLTAELPALVAVLDPLWGRIIRLAVNSTHWPVMPRKIPVSGHVVKVGWFTTELDPHGLILRSYGAGRWDLLVVPPQTAPESAAWLMAAAVDPARMQSASRLMEEAGHRRHSTGGGTSQQEVWDSEGGRTVPPRTEHPAVPAAPPASTEKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9G2</accession>
    <name>A0A0F7N9G2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_23475</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017931.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_23475"/>
    <dbReference type="EnsemblBacteria" id="AKH84676">
        <property type="protein sequence ID" value="AKH84676"/>
        <property type="gene ID" value="AA958_23475"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_23475"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4949"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH84676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="104" mass="10634" checksum="58CC757CE1DBCD17" modified="2015-07-22" version="1">MISITKLDGRAADGREVVSSCLLALSKFQVPATGVSGVRGGLGVRDERPTKALLVAAAQAPAYAAAAAGADLQQEWANGAFAGGIAATTHMRAFRGPEPWKEPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9G5</accession>
    <name>A0A0F7N9G5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AsnC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_20475</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018840218.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_20475"/>
    <dbReference type="EnsemblBacteria" id="AKH84168">
        <property type="protein sequence ID" value="AKH84168"/>
        <property type="gene ID" value="AA958_20475"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_20475"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4315"/>
    <dbReference type="OrthoDB" id="1844486at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019885">
        <property type="entry name" value="Tscrpt_reg_HTH_AsnC-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13404">
        <property type="entry name" value="HTH_AsnC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00519">
        <property type="entry name" value="HTH_ASNC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH84168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="150" mass="16141" checksum="8611518263270C8A" modified="2015-07-22" version="1">MDAVDRQLIQALRENGRASYAELGRLVGLSGPSVTDRINRLEAAGVITGYRATVDAALLGRGVTALVGISLSEAVDHDDVADRLRDLPEIEDCFFIAGADSFMLKVRAPDVDGLGKTVRRMSRIKGVSHTATTVVLSTMWESRVGEIAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9H6</accession>
    <name>A0A0F7N9H6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_20040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017384.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_20040"/>
    <dbReference type="EnsemblBacteria" id="AKH84094">
        <property type="protein sequence ID" value="AKH84094"/>
        <property type="gene ID" value="AA958_20040"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_20040"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4222"/>
    <dbReference type="OrthoDB" id="1891666at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M23" evidence="2">
        <location>
            <begin position="268"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH84094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="373" mass="38966" checksum="030F26F126305EEE" modified="2015-07-22" version="1">MASYRSGPGYGHGYDDYGYDGYAPGGHAPEGYAPTGYAAEEPVDEVLPEDDLPSRGRRRLPRQRGGSMARSGAVLGVGVFAAVGAGSMATAQEKPPVAISMPDQVDTVANRIGAQLPDAESLPGVGDLMPSEEEPASDSVVTTAPLTQVSYASDTDTANQPADSGEALRARILEQAEQQQAEADASARAAAEAEAAKQAAEEAAEAKAAEEERQRRLEEERRRKAEEEARRKAEAERLAKLAASYVAPVANYTLTSTFGESGDMWAAGHTGQDFAASTGTPVKAVHGGTITEAGWAGSYGYRIVLTLEDGTEVWYCHLSSIIQSSGEVTTADVIGRVGATGNVTGPHLHLEVRPGGGDAVDPLAWLRNNGAPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-08-12" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9M1</accession>
    <name>A0A0F7N9M1_9ACTN</name>
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        <recommendedName>
            <fullName evidence="2">Antitoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_23845</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Antitoxin component of a type II toxin-antitoxin (TA) system.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the phD/YefM antitoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017988.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH84736">
        <property type="protein sequence ID" value="AKH84736"/>
        <property type="gene ID" value="AA958_23845"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_23845"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5025"/>
    <dbReference type="OrthoDB" id="2047723at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006442">
        <property type="entry name" value="Antitoxin_Phd/YefM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036165">
        <property type="entry name" value="YefM-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02604">
        <property type="entry name" value="PhdYeFM_antitox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143120">
        <property type="entry name" value="SSF143120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH84736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="94" mass="10190" checksum="6B13C975A684530E" modified="2015-07-22" version="1">MSAISVREFSYNPSAVFARVEQGEAVQVTRHGNVIAILLPASGAAERYADLVSRGQIRLKAATSADLSRLPHYEVAEDADPLAVLLAEREDDPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9R6</accession>
    <name>A0A0F7N9R6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_27150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018535.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_27150"/>
    <dbReference type="EnsemblBacteria" id="AKH85300">
        <property type="protein sequence ID" value="AKH85300"/>
        <property type="gene ID" value="AA958_27150"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_27150"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5721"/>
    <dbReference type="OrthoDB" id="522981at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004013">
        <property type="term" value="F:adenosylhomocysteinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042172">
        <property type="entry name" value="Adenosylhomocyst_ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000043">
        <property type="entry name" value="Adenosylhomocysteinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020082">
        <property type="entry name" value="S-Ado-L-homoCys_hydrolase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23420">
        <property type="entry name" value="PTHR23420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05221">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00738">
        <property type="entry name" value="ADOHCYASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="135" mass="14689" checksum="68765BD2A65D928F" modified="2015-07-22" version="1">MPLLRDPALAEEGARKIDFAYSRMPVLRALTARWAEEKPLTGARIAACLHVTTETANLCRALVAGGAQVALCASNPLSTKDDVAAAIQRDLGAEVFAVHGCDRDTYYRQLDAYGITLDELGPHQRDYLASWRTGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9W2</accession>
    <name>A0A0F7N9W2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_24400</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018083.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_24400"/>
    <dbReference type="EnsemblBacteria" id="AKH84831">
        <property type="protein sequence ID" value="AKH84831"/>
        <property type="gene ID" value="AA958_24400"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_24400"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5143"/>
    <dbReference type="OrthoDB" id="1213908at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031725">
        <property type="entry name" value="ASMT_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="O_MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11746">
        <property type="entry name" value="PTHR11746"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16864">
        <property type="entry name" value="Dimerisation2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Dimerisation2" evidence="4">
        <location>
            <begin position="11"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransf_2" evidence="3">
        <location>
            <begin position="166"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="2">
        <location>
            <begin position="220"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH84831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="333" mass="35838" checksum="41EE719A5B5C822F" modified="2015-07-22" version="1">MTDGRPNSDRVLRLITGYWATGIVGTAAKYALFTHIEDGARTVDALAARAELSVRGTQALLDGLVSLDLVERRGGEYHNTEEAATYLVDHLPTSLTSFAQFKMGHMGSLTDLPEVVRAGGPLSTSVVEVADNPHWEALVTALAASSVPATEIAAEALGIAGAGEVSILDIGGGSGIYCGTFLELNPAARATQLDWAPINAIARRLLAERGVGERVDYIDGDFHTTEFGTSAYDYVVYSNIARQEGPQDNMALFAKIRAALKPGGTLIVSDYVVDDDRGGGSKYALQFASEMLLKSRHGSTWRRADYHEWLVKSEFEEITFQPTPSPATLIFAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9Z6</accession>
    <name>A0A0F7N9Z6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">50S ribosomal protein L30</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpmD</name>
        <name evidence="7" type="ORF">AA958_21265</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2 5">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL30 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="rpmD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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    <feature type="domain" description="Ribosomal_L30" evidence="6">
        <location>
            <begin position="4"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH84304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="60" mass="6909" checksum="808F7020E3B8E66F" modified="2015-07-22" version="1">MAQLKITQSKSYIGSKQNHRDTLRTLGLRRLHDSVVRDDSPQVRGMVHTVRHLVTVEEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NA03</accession>
    <name>A0A0F7NA03_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Molybdopterin-guanine dinucleotide biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_16470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_16470"/>
    <dbReference type="EnsemblBacteria" id="AKH83537">
        <property type="protein sequence ID" value="AKH83537"/>
        <property type="gene ID" value="AA958_16470"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_16470"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3466"/>
    <dbReference type="OrthoDB" id="651103at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045598">
        <property type="entry name" value="DUF6457"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025877">
        <property type="entry name" value="MobA-like_NTP_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20058">
        <property type="entry name" value="DUF6457"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12804">
        <property type="entry name" value="NTP_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transf_3" evidence="1">
        <location>
            <begin position="26"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6457" evidence="2">
        <location>
            <begin position="215"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH83537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="304" mass="30852" checksum="778A7C383767EA77" modified="2015-07-22" version="1">MEESGGTGSGAAHAGAGAGAAGAYAAVVLAGGAARRLGGVDKMALRVGGRTLLDRVLRACRGAGQTVVVGPRRPTVRPVTWTREAPPGGGPVAALAAALPFTSAGTVVLLSADLPFLDDGTVRTLRAALAAAGDGVDGAMLVDGTGRDQPLVAAYRSESLRRGLALLAVEYGGVAGLPLRLLTGELTLVRSASGATFDCDTWEDLATARDRIREHGHVLDEWLAAVKEELGLDTEVDTRVLLDLARDAAHGVARPAAPLTTFLVGYAAGRAGGGPEAVAEAAHKVTALTERWAEEAAEEGRSGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAB7</accession>
    <name>A0A0F7NAB7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_17185</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 4">Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the UPF0677 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016961.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH83657">
        <property type="protein sequence ID" value="AKH83657"/>
        <property type="gene ID" value="AA958_17185"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_17185"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3614"/>
    <dbReference type="OrthoDB" id="847145at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011610">
        <property type="entry name" value="CHP00027_methylltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007213">
        <property type="entry name" value="Ppm1/Ppm2/Tcmp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04072">
        <property type="entry name" value="LCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00027">
        <property type="entry name" value="mthyl_TIGR00027"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH83657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="266" mass="29710" checksum="4C4A020C5654266C" modified="2015-07-22" version="1">MRAIESRRSDRLFDDPYAHRLCGQVGPCLLEELRAATLPAGQPRRMPDVLDVNAVRTRFFDDRLRADVHEGTQVVLPASGMDCRAYRTEWPRGVRWYEIDRPAVVAHKQARLADVRPCVDRRAVGADLTGPNWERRLVAAGYEPQVPSVWLLEGLLCYLREGEVNDLLDRIRRVTAPGSVLLADCVGAAAFTVPHASGQLNMFARWGCPWHFGTDEPEVLFSGHGMRATSVQPGEAPADYPRWSHAVPPRSAGGVRRIFLIRAVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAU5</accession>
    <name>A0A0F7NAU5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_22800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH84559">
        <property type="protein sequence ID" value="AKH84559"/>
        <property type="gene ID" value="AA958_22800"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_22800"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4800"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH84559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="68" mass="6899" checksum="590FCDF0C4DE16DF" modified="2015-07-22" version="1">MPGGSRVQVPHLASEFAERRQVETGKAELDRAGGVEAGVGREVGGKALGQRGQTLGTLLSVVEGRGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAX8</accession>
    <name>A0A0F7NAX8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_23375</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018834999.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_23375"/>
    <dbReference type="EnsemblBacteria" id="AKH84658">
        <property type="protein sequence ID" value="AKH84658"/>
        <property type="gene ID" value="AA958_23375"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_23375"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4928"/>
    <dbReference type="OrthoDB" id="1975208at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021456">
        <property type="entry name" value="DUF3107"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11305">
        <property type="entry name" value="DUF3107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH84658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="75" mass="7845" checksum="7EADFA3FE493934E" modified="2015-07-22" version="1">MEVKIGVQHAPREISLESGQSAEEIESAVADALGGKSEVLTLVDDRGRKILVPSGRIAYVEIGAPTARKVGFGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBC7</accession>
    <name>A0A0F7NBC7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_24015</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018021.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_24015"/>
    <dbReference type="EnsemblBacteria" id="AKH84769">
        <property type="protein sequence ID" value="AKH84769"/>
        <property type="gene ID" value="AA958_24015"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_24015"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5061"/>
    <dbReference type="OrthoDB" id="1994461at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH84769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="85" mass="9412" checksum="BD9007159535B68C" modified="2015-07-22" version="1">MRTEDTAFVGGPLDGRTLAVHVGATGRPPKVYEVPVPDPGGGPPAVHVYRLEPANLSPRLKLPRGWVYTYDPEGVPERRKWPWAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBD3</accession>
    <name>A0A0F7NBD3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_24070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_24070"/>
    <dbReference type="EnsemblBacteria" id="AKH84778">
        <property type="protein sequence ID" value="AKH84778"/>
        <property type="gene ID" value="AA958_24070"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_24070"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5073"/>
    <dbReference type="OrthoDB" id="2091189at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="146" mass="15215" checksum="DC324A04D15B4895" modified="2015-07-22" version="1">MTRPAEGQGDISGATRSEMSGTAQQANGLFDEALATYDRAAALHRRVGDGGREALAWHGTGETCRALARADEAAACHRRAAARFHELGDPWHEAVALDGLAAAVRSDDPAGARGHWETALVLLAGYGDQRTAALRDGITVRLGAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBL4</accession>
    <name>A0A0F7NBL4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA (guanine-N(7)-)-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">tRNA (guanine(46)-N(7))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">tRNA(m7G46)-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">trmB</name>
        <name evidence="3" type="ORF">AA958_20080</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>guanosine(46) in tRNA + S-adenosyl-L-methionine = N(7)-methylguanosine(46) in tRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42708"/>
            <dbReference type="Rhea" id="RHEA-COMP:10188"/>
            <dbReference type="Rhea" id="RHEA-COMP:10189"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74480"/>
            <dbReference type="EC" id="2.1.1.33"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">tRNA modification; N(7)-methylguanine-tRNA biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.33" evidence="1"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017392.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_20080"/>
    <dbReference type="EnsemblBacteria" id="AKH84102">
        <property type="protein sequence ID" value="AKH84102"/>
        <property type="gene ID" value="AA958_20080"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_20080"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4230"/>
    <dbReference type="OrthoDB" id="1025521at2"/>
    <dbReference type="UniPathway" id="UPA00989"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008176">
        <property type="term" value="F:tRNA (guanine-N7-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01057">
        <property type="entry name" value="tRNA_methyltr_TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003358">
        <property type="entry name" value="tRNA_(Gua-N-7)_MeTrfase_Trmb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23417">
        <property type="entry name" value="PTHR23417"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02390">
        <property type="entry name" value="Methyltransf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00091">
        <property type="entry name" value="TIGR00091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51625">
        <property type="entry name" value="SAM_MT_TRMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="1">
        <location>
            <begin position="228"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH84102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="252" mass="27986" checksum="D360D3E03F73BDA6" modified="2015-07-22" version="1">MSDHSDQHDRPQPRFPDGPAPAPAGPHDERRIRSFVPRRSRVTLAQGEALKRLWPKWGFDIDGASVLDLDDLFCGLPVILEIGFGMGEATADMAAADPATGILAVDVHTPGQGNLLRLIEQRGLTNVRIGNGDAVILLREMLPPAALAGMRIYFPDPWPKKRHHKRRLIQPEFLALAASRMAPGAVLHCATDWEPYGEWMLETLEASPYFENTHPGGYAPRPAFRPRTRFEGQGLGKGHIVNDLLFRRISDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NC42</accession>
    <name>A0A0F7NC42_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GCN5 family acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_21120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017557.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_21120"/>
    <dbReference type="EnsemblBacteria" id="AKH84277">
        <property type="protein sequence ID" value="AKH84277"/>
        <property type="gene ID" value="AA958_21120"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_21120"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4447"/>
    <dbReference type="OrthoDB" id="1885106at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="123"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="264" mass="28506" checksum="D930F6068368F7FB" modified="2015-07-22" version="1">MDAKPFLSGLSDDAVTITRVADRHWQALDDDLVVGSGYAEYRADGRLFVGIDAWHPDTFDRIARAMLPELPAPLYTVVDEADAGMTDAWRRAGFTVGRREWEYVMATDPRDTGLDGALPPAGVTVVPAGEADEGLLRAVDRTIRDEVEAAAGWWQSMPAEVIIRPAGDTVVDPAKYAVAAAPDRYLGLIRVVTVNRSRVGLVAVRAGEQRRGIARALLAHALGTLHRSGTTAAWTEVHESNRAATALFEGIGARPVSSNLELVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCB9</accession>
    <name>A0A0F7NCB9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_30530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019064.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH85836">
        <property type="protein sequence ID" value="AKH85836"/>
        <property type="gene ID" value="AA958_30530"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_30530"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6452"/>
    <dbReference type="OrthoDB" id="2153720at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519291" evidence="1">
        <location>
            <begin position="33"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="127" mass="12649" checksum="6506DD90B8A13CE3" modified="2015-07-22" version="1">MRRVPAGCAVLIALLAGCSGSGELDPVTGEWAADGAQPAGFAHFAENATISVDGGKATLGTPPSSLCGGATVEATGDDGFRIAFAGANSCVTVNVPVSLDVRVEGDTLRATPTGAPGDAVFRFRRAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCD0</accession>
    <name>A0A0F7NCD0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pyridoxal-5'-phosphate-dependent protein subunit beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_32370</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019367.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_32370"/>
    <dbReference type="EnsemblBacteria" id="AKH86140">
        <property type="protein sequence ID" value="AKH86140"/>
        <property type="gene ID" value="AA958_32370"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_32370"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6833"/>
    <dbReference type="OrthoDB" id="428821at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901607">
        <property type="term" value="P:alpha-amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PALP" evidence="3">
        <location>
            <begin position="64"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH86140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="376" mass="38708" checksum="16F4D85D2B87D99A" modified="2015-07-22" version="1">MTHLVDERSGRTYPFDALRWRADDGTPLQVGGVPGIGRDDIDTAERSLWRYRAALPFGIEAPVSLGEGRTPLLARRWGGGEVFFKPEWFGPTGSFKDRGSTVMISALARLGVAEVIEDSSGNGGASVAAYCAAAGIRARILAPEGTSPAKVLQARAYGAEVELVPGGRDATAAEAVRRAATVPYAGHNWHPLFLQGTKTLAYELWEDLGFAAPDCVVTVAGAGSTVLGLDAGFGELLAAGHIDRRPRILAAQPANCAPIHASFAAGADGPVPTGFAPTIAEGTAIREPVRLPEVLRAVRRSGGDMAAIGEDGIRAAVVRLAALGLYAEPTSATAAAAVDVFRARGAIRPGETTAVLLTGTGLKAAPVLAGVFGGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCG4</accession>
    <name>A0A0F7NCG4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_26345</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018405.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_26345"/>
    <dbReference type="EnsemblBacteria" id="AKH85164">
        <property type="protein sequence ID" value="AKH85164"/>
        <property type="gene ID" value="AA958_26345"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_26345"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5546"/>
    <dbReference type="OrthoDB" id="1734230at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="130"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="170"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="298"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="128"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH85164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="334" mass="34695" checksum="BC662221AC25186C" modified="2015-07-22" version="1">MSTEALGEEPGFEPKGPPATEPPASEPPAPGPPAEPSAADPRALARARRRRSAARFWRAYRKQRAGLGGLVALVVIAFVALAAPLLAGSDADSVTDAPGTALEDPSTEFPLGTDQFGRSVLDLLVHGARISLTVGLLAAALTVGIGTLVGMVAGHYGGWLSGVIMRVTDFFLVMPTLVLAIVLATVMSRSVTTVIIAIGVAAWPKTARLVRAQTLAIEARPYVERARALGGGHTHIMLRHVLPNVMPLVLAQTTLVISEAILTEATLAFLGLGDPQVISWGGMLQDAREAGAISSGHWSFLVPPGIAIAVVALCFTLSGRALESVLNPKLGVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCH5</accession>
    <name>A0A0F7NCH5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Polyketide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_32660</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019412.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_32660"/>
    <dbReference type="EnsemblBacteria" id="AKH86185">
        <property type="protein sequence ID" value="AKH86185"/>
        <property type="gene ID" value="AA958_32660"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_32660"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6899"/>
    <dbReference type="OrthoDB" id="1788762at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1090">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006765">
        <property type="entry name" value="Polyketide_synth_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038474">
        <property type="entry name" value="Polyketide_synth_cyclase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04673">
        <property type="entry name" value="Cyclase_polyket"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH86185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="109" mass="12867" checksum="4CD0589EFBC83C3E" modified="2015-07-22" version="1">MAYRALMVLRMNPADAPHVAAAFAEHDETVLPREIGVRRRVLFRFHDLYMHLIEADDDIMDRLYRARSSALFQQVNERVGRFLTPYDAAWKELKDSRAHIFYTWEADTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCK1</accession>
    <name>A0A0F7NCK1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 3">Adenosine deaminase</fullName>
            <ecNumber evidence="1 3">3.5.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2 3">Adenosine aminohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">add</name>
        <name evidence="5" type="ORF">AA958_22090</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>2'-deoxyadenosine + H(+) + H2O = 2'-deoxyinosine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:28190"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17256"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:28997"/>
            <dbReference type="EC" id="3.5.4.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>adenosine + H(+) + H2O = inosine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:24408"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:17596"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenosine deaminase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.4" evidence="1 3"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017699.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_22090"/>
    <dbReference type="EnsemblBacteria" id="AKH84437">
        <property type="protein sequence ID" value="AKH84437"/>
        <property type="gene ID" value="AA958_22090"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_22090"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4653"/>
    <dbReference type="OrthoDB" id="554648at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046936">
        <property type="term" value="F:2'-deoxyadenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004000">
        <property type="term" value="F:adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009168">
        <property type="term" value="P:purine ribonucleoside monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00540">
        <property type="entry name" value="A_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028893">
        <property type="entry name" value="A_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001365">
        <property type="entry name" value="A_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006330">
        <property type="entry name" value="Ado/ade_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409">
        <property type="entry name" value="PTHR11409"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00962">
        <property type="entry name" value="A_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01430">
        <property type="entry name" value="aden_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="A_deaminase" evidence="4">
        <location>
            <begin position="23"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="220"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="30"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="3">
        <location>
            <position position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00031852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH84437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="376" mass="41932" checksum="15ADA3AB9DEE1E6D" modified="2015-07-22" version="1">MADDNRGAPARAVPDPERIRRAPKVLLHDHLDGGLRPATIVDIARETGYDGLPETDPERLGVWFREAADSGSLERYLETFAHTCAVMQTRDALVRVAAECAEDLAADGVVYAEVRYAPEQHLQGGLSLEQVVEAVNEGFREGERRAHAAGHRIRVGALLTAMRHAARSLEIAELANRYRDLGVVGFDIAGAEAGFPPTRHLDAFEYLKRENNHFTIHAGEAFGLPSIWQALQWCGADRLGHGVRIIDDIHVADDGTVKLGRLAAYVRDKRIPLELCPTSNLQTGAATSYAEHPIGLLRRLYFRATVNTDNRLMSGTSMSREFEELVRTFHYTLDDMQWFTVNAMKSAFIPFDERLAMINDVIKPGYAGLKSEWLFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCY5</accession>
    <name>A0A0F7NCY5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">D-ribose transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_27360</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018569.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_27360"/>
    <dbReference type="EnsemblBacteria" id="AKH85334">
        <property type="protein sequence ID" value="AKH85334"/>
        <property type="gene ID" value="AA958_27360"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_27360"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5766"/>
    <dbReference type="OrthoDB" id="551294at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="10"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="246"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="501"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="42"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH85334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="530" mass="55751" checksum="E55FF12D7AFF00FD" modified="2015-07-22" version="1">MATPESSPVVSLRGVGKSYRAVTALAAVDLDIAPGEVHCLAGENGAGKSTLIKVLTGAVARDGGTYRVLGREMRAHVTPAEARAAGIGVVYQELSLMPELTVASNLSMFGIPARAGWVDRRRQRAQAGEMLARVGLADLDPRTRVSELTTATRQLVEIARVLGQDARLVVFDEPTTALSAQEADALLARIATLRDEGVSVLYVTHRLEEMSAVGDRVTVLRDGRVVETRPMAAYDEDSLVQSMVGRRIENLYPGERPDPGDVRLELRGLRPAGFPAPVDLTVRRGEVVGLAGLLGSGRTELLRAAFGADPVLGGEVLVDGRRVHATSPRAAARAGLGLLPEDRKESGLLPGLSIEKNVAIASLPRAGTFGVLRRRRMREHVTAASAGLRIKLGDWGDPVSSLSGGNQQKTLVARWRATGAKVLLLDEPTKGVDVGSKADIYQVIAELAADGLAIVVVSSYLPELLGLCDRVEVVRQRRLVGSLPAAEATEEAVLRLASPVGPAAAPPAAGAPATGRPGPAEPSAPSLESQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7ND00</accession>
    <name>A0A0F7ND00_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Succinate dehydrogenase</fullName>
            <ecNumber evidence="6">1.3.5.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">sdhA</name>
        <name evidence="6" type="ORF">AA958_23115</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.3.5.1" evidence="6"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017869.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_23115"/>
    <dbReference type="EnsemblBacteria" id="AKH84612">
        <property type="protein sequence ID" value="AKH84612"/>
        <property type="gene ID" value="AA958_23115"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_23115"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4873"/>
    <dbReference type="OrthoDB" id="153138at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033765">
        <property type="term" value="F:steroid dehydrogenase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008177">
        <property type="term" value="F:succinate dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037099">
        <property type="entry name" value="Fum_R/Succ_DH_flav-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015939">
        <property type="entry name" value="Fum_Rdtase/Succ_DH_flav-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030664">
        <property type="entry name" value="SdhA/FrdA/AprA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632">
        <property type="entry name" value="PTHR11632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02910">
        <property type="entry name" value="Succ_DH_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46977">
        <property type="entry name" value="SSF46977"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="SSF56425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="4">
        <location>
            <begin position="10"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="Succ_DH_flav_C" evidence="5">
        <location>
            <begin position="507"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="300"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="482"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH84612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="662" mass="72485" checksum="D8C514D95426AA03" modified="2015-07-22" version="1">MTQVERQQWDVVVVGAGGAGLRAAIEAREQGLRTAVICKSLFGKAHTVMAEGGIAASMGNVNAGDNWQVHFRDTMRGGKFLNSWRMAELHAKEAPDRVWELETWGALFDRTKDGKISQRNFGGHEYPRLAHVGDRTGLELIRTLQQKVVSLQQEDFKAGGDYESRIKVFQECTVTRILKAPDGRVSGVFCYERESGRFFVIEAPSVVLATGGIGKSFKVTSNSWEYTGDGHALALLAGASLINMEFVQFHPTGMVWPPSVKGILVTESVRGDGGVLRNSEGKRFMFDYIPDVFKEKYAQSEDEGDRWYEDPDNNRRPPELLPRDEVARAINSEVKAGRGSPHGGVFLDVSTRLPAEEIKRRLPSMHHQFKELADVDITAEPMEVGPTCHYVMGGVDVDPDTAAALGVPGLFAAGEVAGGMHGSNRLGGNSLSDLLVFGRRAGLYAAEYARDAAGSADGRPEVDEEQIAAASAEALRPFSAEAGAGAGAGGREGDGGAKPPENPYTLHQELQQSMNDLVGIIRREAEMSEALTRLGDLRVRARGAGVEGHRQFNPGWHLALDMRNMLLVSECVARAARERTESRGGHTRDDHPAMDRDWRKQNLVCRLADPAGGALPAADVPDPERGQIRLEKREMPPIRPDLLDLFEKEELVKYLTDEELTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7ND06</accession>
    <name>A0A0F7ND06_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_23175</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017879.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_23175"/>
    <dbReference type="EnsemblBacteria" id="AKH84622">
        <property type="protein sequence ID" value="AKH84622"/>
        <property type="gene ID" value="AA958_23175"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_23175"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4886"/>
    <dbReference type="OrthoDB" id="2043211at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046095">
        <property type="entry name" value="DUF6113"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19608">
        <property type="entry name" value="DUF6113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH84622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="207" mass="20008" checksum="F47A18F113850BFF" modified="2015-07-22" version="1">MSAKKRSVRPKSAARGGNPGDTGAERARAGDGGAANGRTSRGGSTGGGSADGGGAEKRGRAAATTKSSPARRPAAPPPGSALARPVTPGHLLTYLAALVLGGLVGLAGSLVQAAWSPGGLLLALAAVGGLCYGAGVATGGRGAGFTAAGGWFLAVIAISLNRPEGDFVFASGLGPQLFLFGGMLTAVICTTLPQLLAVAAPPSRLPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7ND68</accession>
    <name>A0A0F7ND68_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sel1 domain-containing protein repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_23545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017942.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_23545"/>
    <dbReference type="EnsemblBacteria" id="AKH84687">
        <property type="protein sequence ID" value="AKH84687"/>
        <property type="gene ID" value="AA958_23545"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_23545"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4964"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="432"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="600" mass="63140" checksum="004CBE3003CA899B" modified="2015-07-22" version="1">MARLSAEGAALLRKGDLDGAEPVLRAATAEGDRAAANNLGVLLYQRGQVHEAAGWWRIAAVGGSPAAAHALGRYYRENGDEPGAEYWLRQSAEAGHALGAYALADLLEHRSDVGAERWFRIAADKGHREAAYRLARILDTGTRARSGSGVETGTRLTPPAAPGAVSLVRGGPGAGDDPVAEAEQWYRQAAARGHVRAALHLGTLLEERGESQEAGRWYVISARGGEPRAACALGFLLRDAGDDASAAVWWRQAARDGDGNAANALGALYADRGEPQEAERWYRAALGAGDVNGAYNLALLCAGENRVEQAEQWYRQAAYTGHCEAANALAVLLLQRGDAAGAEPWFSKAAEAGSVDAAFNLGIIHAGRDDETGARQWYERAASAGHVEAALQVGIALLREGEEKDAEHRLRTAAEGGSAEGAFRLAALLDDRRPGAGAGPGPDAAGSRGARAWGGPGPAGTAGGSDADAAECERWYEQAARQGHRRAQVRLGMRAAARGDTEAAGRWYRAAAEAGSRNGAFNLGLLLAREGSVPEAAIWWRRAAEHGHGRAALRLALLAARRGDLPESQHWSSRAVELGPAEVAERAARLRDALAQELTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDF4</accession>
    <name>A0A0F7NDF4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Lactate 2-monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_28090</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018688.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_28090"/>
    <dbReference type="EnsemblBacteria" id="AKH85454">
        <property type="protein sequence ID" value="AKH85454"/>
        <property type="gene ID" value="AA958_28090"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_28090"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5920"/>
    <dbReference type="OrthoDB" id="1186741at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012133">
        <property type="entry name" value="Alpha-hydoxy_acid_DH_FMN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008259">
        <property type="entry name" value="FMN_hydac_DH_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000138">
        <property type="entry name" value="Al-hdrx_acd_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00557">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0288">FMN</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="6">
        <location>
            <begin position="20"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="284"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="99"/>
            <end position="101"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="315"/>
            <end position="319"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="338"/>
            <end position="339"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH85454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="389" mass="41377" checksum="D231F51EE95E5022" modified="2015-07-22" version="1">MNLPFGNYQNEIYLNGLADELPPFTTDLTALEQSARERLADGPFWYVAGAAGSGATARANRSAFDRVRLVPRMLTGATERSPATTVLGTALPAPVLLAPVGVQSIVHPDGELATARAAAALGLPMVMSTASSYTIEEVAEASGAGPRWYQLYWPNDDEVCVSILARARAAGFTALVVTLDTWTLAWRPRDLDAAYLPFIRGVGTAVAFSDPAFRAGLEKPPEEDLGAAVLRWVPMFTGKDRTWDRLPFLREHWDGPILLKGVQHPDDARRAADAGMDGVVVSNHGGRQVDGAVASLDVLPEVAAAVGDRVEVLFDSGVRTGADVLKALALGARAVLYGRPYAYGLAHGGEAGVTHVLRSLLADLDLTLGLSGHRSVRELGPGDVRRLPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDF7</accession>
    <name>A0A0F7NDF7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Lon protease</fullName>
            <ecNumber evidence="5 6">3.4.21.53</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ATP-dependent protease La</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">lon</name>
        <name evidence="13" type="ORF">AA958_23955</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6 9">
            <text>Hydrolysis of proteins in presence of ATP.</text>
            <dbReference type="EC" id="3.4.21.53"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5 6">Homohexamer. Organized in a ring with a central cavity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="5">By heat shock.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 6 9 10">Belongs to the peptidase S16 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.53" evidence="5 6"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018009.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_23955"/>
    <dbReference type="EnsemblBacteria" id="AKH84757">
        <property type="protein sequence ID" value="AKH84757"/>
        <property type="gene ID" value="AA958_23955"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_23955"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5049"/>
    <dbReference type="OrthoDB" id="128102at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01973">
        <property type="entry name" value="lon_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027543">
        <property type="entry name" value="Lon_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004815">
        <property type="entry name" value="Lon_bac/euk-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008269">
        <property type="entry name" value="Lon_proteolytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027065">
        <property type="entry name" value="Lon_Prtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003111">
        <property type="entry name" value="Lon_prtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046336">
        <property type="entry name" value="Lon_prtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008268">
        <property type="entry name" value="Peptidase_S16_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10046">
        <property type="entry name" value="PTHR10046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05362">
        <property type="entry name" value="Lon_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02190">
        <property type="entry name" value="LON_substr_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001174">
        <property type="entry name" value="Lon_proteas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00464">
        <property type="entry name" value="LON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00763">
        <property type="entry name" value="lon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51787">
        <property type="entry name" value="LON_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51786">
        <property type="entry name" value="LON_PROTEOLYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01046">
        <property type="entry name" value="LON_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="5 6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 5 6" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0720">Serine protease</keyword>
    <keyword evidence="4 5" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="Lon N-terminal" evidence="12">
        <location>
            <begin position="13"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="Lon proteolytic" evidence="11">
        <location>
            <begin position="610"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 7 9">
        <location>
            <position position="700"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 7 9">
        <location>
            <position position="743"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <begin position="368"/>
            <end position="375"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR001174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001174-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001174-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AKH84757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="807" mass="86282" checksum="02AB410183BC4595" modified="2015-07-22" version="1">MATESGSSTPLALPVLPLDDEVVLPGMVVPLDLSDGEVRAAVEAAQAAARGSGRKPRVLLVPRVDGTYVGTGVLGRVEQVGRLADGDPGALIRGVARIRIGAGTTGPGAALWVEGTEIEESVPDPVPGAVTELTKEYKAVATDWLRKRGAWQVVDRVQQIDDVGQLADNSGYSPFLTIEQRVELLETADPVARLKLATQWLKEHLAEQDVAESIAKDVQEGVDKQQREFLLRRQLEAVRKELRELNGEPEGEESDDYRARVEAADLPGKVREAALKEVGKLERSSDASPEGGWIRTWLDTVLEMPWSERTQDAYDITGAKEILDADHAGLEDVKERITEYLAVRKRRADRGLGLVGGRRGGAVLALVGPPGVGKTSLGESVARAMGRKFVRVALGGVRDEAEIRGHRRTYVGALPGRVVRAIKEAGSMNPVVLLDEIDKVGSDFRGDPAAALLEVLDPAQNHTFRDHYLEVELDLSDVVFLATANVLEAIPEALLDRMELVRLDGYTEDEKVTIARDHLLPRQLERAGLEAGEVAVDDDALRKLAGEYTREAGVRNLERALARLLRKIAAQHELGDAKLPYTVGVDALRPLIGRPHHTPESATDPAERRTAVPGVATGLAVTGAGGDVLYIEASLADPESGASGLTLTGQLGDVMKESAHIALSFLRSRGAELELPVADLKDRGIHLHVPAGAVPKDGPSAGITMTTALASLLSGRQVRTDVAMTGEVSLTGRVLPIGGVKQKLLAAHRAGVTTVIIPKRNEPDLDDVPAEVLEKLEVHPVSDVRHVLDLALTPAAATAQPGVPVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDH7</accession>
    <name>A0A0F7NDH7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Proteinase inhibitor I78</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_04835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019786.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_04835"/>
    <dbReference type="EnsemblBacteria" id="AKH86550">
        <property type="protein sequence ID" value="AKH86550"/>
        <property type="gene ID" value="AA958_04835"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_04835"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1018"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021719">
        <property type="entry name" value="Prot_inh_I78"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11720">
        <property type="entry name" value="Inhibitor_I78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="74" mass="8014" checksum="90A578D34C3A471D" modified="2015-07-22" version="1">MATPPNLPTPSPNPDDDPESYVGLAAADAEERARDRGWTTVRSLPPGAIITMEFMGGRLNFTVQDGRVTRSWVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDN9</accession>
    <name>A0A0F7NDN9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_24270</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aromatic prenyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018064.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH84812">
        <property type="protein sequence ID" value="AKH84812"/>
        <property type="gene ID" value="AA958_24270"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_24270"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5114"/>
    <dbReference type="OrthoDB" id="747559at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd13931">
        <property type="entry name" value="PT-CloQ_NphB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033964">
        <property type="entry name" value="Aro_prenylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020965">
        <property type="entry name" value="Prenyltransferase_CloQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036239">
        <property type="entry name" value="PrenylTrfase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11468">
        <property type="entry name" value="PTase_Orf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00036">
        <property type="entry name" value="Aromatic_Prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01163">
        <property type="entry name" value="II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143492">
        <property type="entry name" value="SSF143492"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH84812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="303" mass="33484" checksum="DD6F606455974831" modified="2015-07-22" version="1">MSGAVELERVYSAIEESAHLVGVACSREKVWPLLSTFGESIEDALLVLSLQTGGRHAGELDYSFTASPGLGDPYPHAVAHGFLEPTDHPVHSLLSDLQGRWTIREHFVDCGVTGGFKKLYAHFPQDLQPVAKLAEVPSVSHAVADNAGLFARYGLDEVAMVGVDYKRQTMNLYFQFTPDGRPEPSALRAMLREIGLYDADEGMLEFASRSMRANITFRWDSSRIVRVAFAPPPGRGLDPAAVPAPIEPHIARFATNAPYAYPGERLNLFGVKWFPDGEFIDVCAYYQLSAGYEPVRLMETHKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDQ6</accession>
    <name>A0A0F7NDQ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_33620</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019573.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_33620"/>
    <dbReference type="EnsemblBacteria" id="AKH86351">
        <property type="protein sequence ID" value="AKH86351"/>
        <property type="gene ID" value="AA958_33620"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_33620"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.7099"/>
    <dbReference type="OrthoDB" id="1046649at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="GH16"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH16" evidence="2">
        <location>
            <begin position="1"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH86351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="248" mass="26898" checksum="22F2C8883D4ED698" modified="2015-07-22" version="1">MTFEDDFDGPAGSAVDGGKWLTETGDNVNNHERQYYTAGNANAALDGQGNLVITARKENPGDYQCWYGRCEYTSARLNTSGRFTTTYGHVEARMKLPRGQGMWPAFWMLGDDIGQVGWPASGEIDVMENVGFEPGTVHGTIHGPDYSGSGGIGAGYSLPGGEAFADGFHTFAVDWSPDEITWSVDGTVYQTRTPADLGGKRWVFDKPFFLILNLAVGGYWPGDPDGSTSFPQQLVVDYVRVTTPDAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDU5</accession>
    <name>A0A0F7NDU5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TYR_PHOSPHATASE_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_28785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018811.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_28785"/>
    <dbReference type="EnsemblBacteria" id="AKH85578">
        <property type="protein sequence ID" value="AKH85578"/>
        <property type="gene ID" value="AA958_28785"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_28785"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6066"/>
    <dbReference type="OrthoDB" id="1972497at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016311">
        <property type="term" value="P:dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026893">
        <property type="entry name" value="Tyr/Ser_Pase_IphP-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13350">
        <property type="entry name" value="Y_phosphatase3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="SSF52799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TYR_PHOSPHATASE_2" evidence="1">
        <location>
            <begin position="111"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="241" mass="25188" checksum="98ADAA66CC4808C7" modified="2015-07-22" version="1">MAARAGRELDWDGCFNVRDLGGLPAAGGRRTRPGALVRADNLDGLTGAGWAAVADHGVRTVVDLRNAIDHRPRLPRPEGIGLVRVPVDELAGNVRWWREWGHLEGTPLTWAAYLEYVPQVAASVVREVAAAPPGGVVVHCTAGRDRTGFASFVLLTLAGVAAADIAADYLLSGPNHRRAAAALGHPDQTLEIAGIQARSGRTATQVITDTHAAFDAAAYLAKAGLPDAAVAAARERLLAPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NEA6</accession>
    <name>A0A0F7NEA6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carbonic anhydrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_06575</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the reversible hydration of carbon dioxide to form bicarbonate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the beta-class carbonic anhydrase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019828.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_06575"/>
    <dbReference type="EnsemblBacteria" id="AKH86581">
        <property type="protein sequence ID" value="AKH86581"/>
        <property type="gene ID" value="AA958_06575"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_06575"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1372"/>
    <dbReference type="OrthoDB" id="1841447at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001765">
        <property type="entry name" value="Carbonic_anhydrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036874">
        <property type="entry name" value="Carbonic_anhydrase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43175">
        <property type="entry name" value="PTHR43175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00484">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00947">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53056">
        <property type="entry name" value="SSF53056"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH86581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="186" mass="20233" checksum="ED81DBCDD487987D" modified="2015-07-22" version="1">MTPAESTSTAENAVAAPTVTDRLVAANRGYAGGFEDPGMDAKPVLRVAVVACMDARLDLHAALGLELGDCHTIRNAGGVVTDDTIRSLTISQRALGTRSVVLIHHTDCGLLRITEEFRFELEAEVGQRPAWSVESFRDLDQDVRQSIRRVETSPFLLHTDDVRGFVFDVRTGLLREVSAEQITAGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NEB7</accession>
    <name>A0A0F7NEB7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribonuclease P protein component</fullName>
            <shortName evidence="6">RNase P protein</shortName>
            <shortName evidence="6">RNaseP protein</shortName>
            <ecNumber evidence="6">3.1.26.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Protein C5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rnpA</name>
        <name evidence="7" type="ORF">AA958_16200</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.</text>
            <dbReference type="EC" id="3.1.26.5"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Consists of a catalytic RNA component (M1 or rnpB) and a protein subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the RnpA family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.5" evidence="6"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020124.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_16200"/>
    <dbReference type="EnsemblBacteria" id="AKH86820">
        <property type="protein sequence ID" value="AKH86820"/>
        <property type="gene ID" value="AA958_16200"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_16200"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3413"/>
    <dbReference type="OrthoDB" id="2014742at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00227">
        <property type="entry name" value="RNase_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000100">
        <property type="entry name" value="RNase_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020539">
        <property type="entry name" value="RNase_P_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33992">
        <property type="entry name" value="PTHR33992"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00825">
        <property type="entry name" value="Ribonuclease_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00188">
        <property type="entry name" value="rnpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00648">
        <property type="entry name" value="RIBONUCLEASE_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH86820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="122" mass="13314" checksum="B249C48D86B3070A" modified="2015-07-22" version="1">MLPAEHRLRRREDFARAVRRGRRAGRPLLVVHLNSGGDPHAAGEDASPTRAGFVVSRAVGPAVARNLVKRRLRHLLRDRLDLLPAGSLVVVRALPGAAEAGYDRLRDDLDAALGRLLGRAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NED8</accession>
    <name>A0A0F7NED8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Glycoside hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AA958_29795</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018951.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_29795"/>
    <dbReference type="EnsemblBacteria" id="AKH85723">
        <property type="protein sequence ID" value="AKH85723"/>
        <property type="gene ID" value="AA958_29795"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_29795"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6290"/>
    <dbReference type="OrthoDB" id="442641at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041542">
        <property type="entry name" value="GH43_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17851">
        <property type="entry name" value="GH43_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH43_C2" evidence="8">
        <location>
            <begin position="307"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="201"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="15"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate" evidence="5">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH85723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="511" mass="54952" checksum="24F9D2444AC08E10" modified="2015-07-22" version="1">MRTYDNPVISGFHPDPSVCRVGGDYYLVCSSFEYFPGLPLFHSKDLVHWEQIGNVLDRPGQLPLPLPGAKASGGLYAPTIRHHRGRYWVINTNVDGGGNFVVSAARPEGPWSDPVWIDLPGIDPDLAWEEDGTCWSAFSGPQGGINLARIDPVEGEVLEGPFATWSGTGLKFPEAPHLYRIGDWWYLLIAEGGTERGHSVSVARSRSPRGPWEGAPANPLLSHSGTARPIQNTGHADLVEAPDGGWWMVLLGVRPRGFTPDVHVLGRETFLTPVEWTEDGWPVVAPVPESHTAPGGAWHPVPAPPARDDFDGPALAPHWISPFARPEESWSLTERPGWLTLSATGTTLDRPGYTFVGRRQQHHDCRVTVAIDPGTGRGGLGVRLDEAHHYELEVGNGEAGVVARIGPLRQTVAARPVPPGPLTLTLAIRTSRLVPASPGLTDAAATGPDTLAFWLGDPGAPDARLLAELDGRYLATEIACGFTGRVIGMYATEGTVAFDWFAYTPASPASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NEF4</accession>
    <name>A0A0F7NEF4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_10065</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019924.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86656">
        <property type="protein sequence ID" value="AKH86656"/>
        <property type="gene ID" value="AA958_10065"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_10065"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2119"/>
    <dbReference type="OrthoDB" id="548749at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021889">
        <property type="entry name" value="DUF3500"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37489">
        <property type="entry name" value="PTHR37489"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12006">
        <property type="entry name" value="DUF3500"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH86656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="309" mass="33961" checksum="8B1D58C9FE57B23F" modified="2015-07-22" version="1">MREAARALLSVLAPEQVRELRAGPARLDTPELREWTYLPGPRPGLSTEELDGDQREAVDALLAAAHSAHGGRLAAGAIEVERHRRELAGRPGPDRYWLRLLGDPDGEGPWGWRMNGHHLAVHVLITPTGLRVTPHFVGSEPAVVASGPRAGRLLGPEEDLARELVTDLDTAARTTAVYSAEPPDDILTRADPFADPDLLPPGLTYAAMTPAQHALLERLVRRYLARAPEAYARACWSDTVAGGLERLSFAWAGGLAPGDRHYYCVRAPDFLIEYDNTQDDGNHAHSVWRHTRHDWGLDLLRAHYESGHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NEG3</accession>
    <name>A0A0F7NEG3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Spermine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_10490</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019939.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_10490"/>
    <dbReference type="EnsemblBacteria" id="AKH86671">
        <property type="protein sequence ID" value="AKH86671"/>
        <property type="gene ID" value="AA958_10490"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_10490"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2210"/>
    <dbReference type="OrthoDB" id="1613081at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006596">
        <property type="term" value="P:polyamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030374">
        <property type="entry name" value="PABS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51006">
        <property type="entry name" value="PABS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PABS" evidence="5">
        <location>
            <begin position="1"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="250"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH86671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="272" mass="28978" checksum="96396F187F67CA47" modified="2015-07-22" version="1">MVDVDGGTAELRPDPGRPRAWMLLLDGAPQSHVDLDDPVHLAFEYQRRLGHAADLVAPAGRPVQVLHLGGGALTLPRYIAATRPRSVQQAVEIDGRLTALVRAELPLPERARIRVRHGDARAVLARMPDGWADLIIGDVFHVARTPAHLTTTEFLGDVRRVLRPGGVYAANLADGPPLAYLRAQIATAAAVFPELCVVAAPAVWRGRRFGNAVLLASAVPLPVGELTRRAATDPQSGRVEHGRALRDFAAGARPVTDATATESPAPPPGVFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NEG7</accession>
    <name>A0A0F7NEG7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SGNH hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_10680</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019945.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_10680"/>
    <dbReference type="EnsemblBacteria" id="AKH86676">
        <property type="protein sequence ID" value="AKH86676"/>
        <property type="gene ID" value="AA958_10680"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_10680"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2246"/>
    <dbReference type="OrthoDB" id="1247435at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519357" evidence="1">
        <location>
            <begin position="27"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH_hydro" evidence="2">
        <location>
            <begin position="226"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH86676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="436" mass="45574" checksum="B71404EC689EBEDC" modified="2015-07-22" version="1">MRNRTGYAVLAALVAVVALLVAGVHALTDRPGVPAAAGAGGSADAAAPASVGGWAGTWAAAQAAAEPGTRDGFAGMSLRNVVHTSIGGARARIHLSNEYGETPLTLTRSSVAVAAGAGAPAAQPETMRPLTFAGAAAVTIPAGRTVTSDPVRLRVPADTDLLVTTYAPAPAGPVTYHPHALQTSYLAAGDHTRDAEGTAYDREFRSWRYVTAVDVWSEHATGAVAVLGDSLTDGTTSTPDANRRWTDYLAVRLREEPGAPRYGVLNLGLSGNRILTDGGTEFPGNGPSGRGRLDRDVLSRTGVKAVIVELGINDILKSPATADADAIVAGLREIARQSRDRGLRVLGATLMPFRGHPAYTPRAERVRQEVNELIRAGGVFDAVLDFDAALRDPDRPARLHPAYDSGDHLHLTDLGFHEMALTLDPADLKPRAQAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NEG8</accession>
    <name>A0A0F7NEG8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6 7">Elongation factor Ts</fullName>
            <shortName evidence="6">EF-Ts</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">tsf</name>
        <name evidence="11" type="ORF">AA958_26005</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6 7">Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the EF-Ts family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018343.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_26005"/>
    <dbReference type="EnsemblBacteria" id="AKH85102">
        <property type="protein sequence ID" value="AKH85102"/>
        <property type="gene ID" value="AA958_26005"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_26005"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5476"/>
    <dbReference type="OrthoDB" id="1405357at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00050">
        <property type="entry name" value="EF_Ts"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036402">
        <property type="entry name" value="EF-Ts_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001816">
        <property type="entry name" value="Transl_elong_EFTs/EF1B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014039">
        <property type="entry name" value="Transl_elong_EFTs/EF1B_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018101">
        <property type="entry name" value="Transl_elong_Ts_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11741">
        <property type="entry name" value="PTHR11741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00889">
        <property type="entry name" value="EF_TS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="SSF46934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54713">
        <property type="entry name" value="SSF54713"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00116">
        <property type="entry name" value="tsf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01126">
        <property type="entry name" value="EF_TS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01127">
        <property type="entry name" value="EF_TS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6 7" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="4 6 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF_TS" evidence="10">
        <location>
            <begin position="73"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Involved in Mg(2+) ion dislocation from EF-Tu" evidence="6">
        <location>
            <begin position="82"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AKH85102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="277" mass="30002" checksum="8BA384E4012906F0" modified="2015-07-22" version="1">MANFTAADVKKLRELTGAGMMDCKKALEEAEGDVDKAVELLRVKGQKGVAKRESRSAENGAVVSLIADDNSSGVLLELKCETDFVAKGDKFIAVADALAEHVAATKPADLEALLASEIDGKTVQAYVDEANATLGEKIVLDRFARFEGAYVGTYMHRTMPDLPPQVGVLVELDKADPQTAKEVAQHIAAFSPRWLSREEVPADTVENERRVAEATSREEGKPEAALPKIVEGRVNGFFKENVLLDQPFAKDPKKSVQKVLDEAGAQVIRFARIRVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NF79</accession>
    <name>A0A0F7NF79_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">OmdA domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_31525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019226.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_31525"/>
    <dbReference type="EnsemblBacteria" id="AKH85998">
        <property type="protein sequence ID" value="AKH85998"/>
        <property type="gene ID" value="AA958_31525"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_31525"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6659"/>
    <dbReference type="OrthoDB" id="1966598at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="203" mass="22070" checksum="9132B7D51E0C2531" modified="2015-07-22" version="1">MASPGSETPASGADSPDGAPVRAFDGPAGLESWLDEHHGLQSGMWLKVAKKGSGIASVTMAEVDDVVLCYGWITGLRRRYDDHYFLQKITPRRPRSQWSQVNVDRVEALTAAGRMREPGLAAVRAAQADGRWEAAYESQKNAEVPPDLAEALAASPRAAAFFDGLGKTDRYLVILRLLRARTEENRAVQLARAVEMLAAGQRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFH5</accession>
    <name>A0A0F7NFH5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AA958_25025</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020400.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_25025"/>
    <dbReference type="EnsemblBacteria" id="AKH87026">
        <property type="protein sequence ID" value="AKH87026"/>
        <property type="gene ID" value="AA958_25025"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_25025"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5274"/>
    <dbReference type="OrthoDB" id="1709780at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023845">
        <property type="entry name" value="DUF3817_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12823">
        <property type="entry name" value="DUF3817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03954">
        <property type="entry name" value="integ_memb_HG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="73"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3817" evidence="8">
        <location>
            <begin position="9"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH87026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="114" mass="12673" checksum="A5AA5460B10EDC4D" modified="2015-07-22" version="1">MDIDTASALRRLRLISAPEAVSFLLLLVCSVLKRTTDFDAVPVMGMIHGLLFIGYVLFLADAWNRTRWPLKRAALYFVLAVLPGGGFVAERMLRRELEAGIIADRARREAVVGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFM0</accession>
    <name>A0A0F7NFM0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_27790</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_27790"/>
    <dbReference type="EnsemblBacteria" id="AKH87071">
        <property type="protein sequence ID" value="AKH87071"/>
        <property type="gene ID" value="AA958_27790"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_27790"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5858"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="5"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="103"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="151"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="55"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH87071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="294" mass="32094" checksum="786DC156829460F5" modified="2015-07-22" version="1">MVVPFGLYAVFVISPFVQTFYYSFTDWSGLSSDFKMVGFDNFTRLMDDERFWAAVRNNLILALAVPLVTLSLGLFFAFMINIGGRSRRGEAVTGVAGAKAYKILYFFPQALSIAVIAALWGYIFTPGIGVLEAVLPSSLSPENGWLGERRFALFAVMIVMCWAMVGFFVVLFSAAIGQIPKEINESALLDGASRARTFFSITLPLIRDTVQTGWVYMGIMALGAESFAVVNIITIGPGGPDDSTQVLGVYLWQTGFTQAQAGRGAAMGVCLFILTMLLAVAALSLGRRRDRIEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-10-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFR8</accession>
    <name>A0A0F7NFR8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_32525</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86163">
        <property type="protein sequence ID" value="AKH86163"/>
        <property type="gene ID" value="AA958_32525"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_32525"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6865"/>
    <dbReference type="OrthoDB" id="2047542at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH86163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="60" mass="6598" checksum="325402F8A036C71E" modified="2015-07-22" version="1">MPPHWTRSLAAAGVGNATLCRHFPTRQALIAAVYDDRLRRVRAAAEETCTSQPAFKALMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFT1</accession>
    <name>A0A0F7NFT1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sulfur carrier protein FdhD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">fdhD</name>
        <name evidence="4" type="ORF">AA958_28835</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FdhD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018820.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_28835"/>
    <dbReference type="EnsemblBacteria" id="AKH85587">
        <property type="protein sequence ID" value="AKH85587"/>
        <property type="gene ID" value="AA958_28835"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_28835"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6076"/>
    <dbReference type="OrthoDB" id="948173at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097163">
        <property type="term" value="F:sulfur carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016783">
        <property type="term" value="F:sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00187">
        <property type="entry name" value="FdhD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003786">
        <property type="entry name" value="FdhD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30592">
        <property type="entry name" value="PTHR30592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02634">
        <property type="entry name" value="FdhD-NarQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015626">
        <property type="entry name" value="FdhD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00129">
        <property type="entry name" value="fdhD_narQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Cysteine persulfide intermediate" evidence="3">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH85587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="276" mass="28870" checksum="FBB4D135F1BDD13B" modified="2015-07-22" version="1">MGRVTVRRPVVRVRGGRVDRRADTLVAEEPLEIRLGGRALAITMRTPGDDFALAAGFLVSEGVVAEGRELAGITYCAGAVDGAEGGNTYNVVDVRLAAGVVVPDITLARNVYTTSSCGLCGKASLDAVRTTTRWPPGDEGMRLAPGILAALPDRLRAGQRVFDRTGGLHAAALFTEGGELIDLREDVGRHNAVDKLIGRALQQDRLPLSGTVLMVSGRASFELAQKAAMAGIPVLAAVSAPSSLAVDLAAETGMTLVGFLRGDTMNVYAGDHRIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NG28</accession>
    <name>A0A0F7NG28_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transporter integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_33240</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019508.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_33240"/>
    <dbReference type="EnsemblBacteria" id="AKH86283">
        <property type="protein sequence ID" value="AKH86283"/>
        <property type="gene ID" value="AA958_33240"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_33240"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.7021"/>
    <dbReference type="OrthoDB" id="1619224at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="235"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="281"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="94"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH86283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="318" mass="34590" checksum="14F328AB80BB5D2A" modified="2015-07-22" version="1">MSVAAPPPPKAAGRGTPPPRTPRARKAALGLDGGTWFLLLPALLPILVLSVGPLLYGASLAFTDAQAGRTEPTEFIGLTNLADLRHDTLFWDSFRIGLIWAVCVTTLQLVLALGLALLLNQNLRFRWFARTLALVPWAMPEVVVGIMWRLVYHQDAGILNETLSRLHLIDENVDWLTSLSLALPAVIAVGVWAGMPQTTVVLLAGLQNVPYELKEAAALDGAGVRRRFTAVTWPAIKPVVIAITALNFIWNFNSFSLVFVLTQGGPGGETRLPMLFAYEEAFAYGQYGYAAAMGLAMIAVIAVFLTLFLRKRLKEEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NGA5</accession>
    <name>A0A0F7NGA5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_01290</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019700.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_01290"/>
    <dbReference type="EnsemblBacteria" id="AKH86479">
        <property type="protein sequence ID" value="AKH86479"/>
        <property type="gene ID" value="AA958_01290"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_01290"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.284"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
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        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
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        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="320"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="11"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="210"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="217"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH86479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="647" mass="68779" checksum="BA1496D65D7F5196" modified="2015-07-22" version="1">MRSGEEFADRYVLKEVIGAGRGGDVWLAHDTVVGQDVALKPERTDGEGETAVRRLLGEPRAMAKFRDHPHVVTLYDVVTVAPEGDGGDAETYWFVMEYVPGGGLDRHPRVSPEQAARIGSQLADALVALHEEGIVHCDVKPANIGLTRRGDAKLLDFGAAYRVGGSETITFNGPFSYTPDYAAPELARGSVPRPVSDVFCLAATLYALVTGTPPRGSEPGERERTGRPEDADTWENTRSLRHLQAEQGFVELDPDAVGPLYPALAAMLRRNPRQRPDATEAKQLLEDVAAAGPRASKDTATALGDAADFDTLTKRRRRPLLAAALGVGAVMALALVFILGGDGEDGKPASEDGQSGQPGARALIGSPHTADVCALADTSVLDQFAGEDVRKDVDYGNFDRCDVLVGVDEETRIDVSIRLLQSSPPQGAEPFRTIGRINIVEDEAESDECSRLLTTGGSTEETVVQVRVNMGEGSVNGGNATLCTVAERAAASAAEILDAGPIPRRASAYPQTSLVWGNACTLLDATALSVVPGLRADVPDAAIANWGCEWSSTVDELDAEVSFFRDQPSSAQDGTVLTLSGYRTVVKTNDEGDTCSALVEHHRYKGQDAVTAAEMVRLDVHGERPTEDLCGMAKDLAASAAARLRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NGD5</accession>
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            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_30395</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
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        </lineage>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_30395"/>
    <dbReference type="EnsemblBacteria" id="AKH85812">
        <property type="protein sequence ID" value="AKH85812"/>
        <property type="gene ID" value="AA958_30395"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_30395"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6422"/>
    <dbReference type="OrthoDB" id="1278667at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037079">
        <property type="entry name" value="AF2212/PG0164-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015018">
        <property type="entry name" value="DUF1905"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08922">
        <property type="entry name" value="DUF1905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH85812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="150" mass="16190" checksum="D7A123B444150330" modified="2015-07-22" version="1">MRFRTMIEPAGNATGFEVPGEVVDGFGAGRRPPVVVEINGHSWRTRIAPVNGRYVVGVSAAHRKASGVVQREEVEAEVRLDTEPREIVEPPELTAALDAEPGARAAYDRLAPTHKRRHVRAVEGAKTAATRERRVARVLAELAGEEAPGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NGS6</accession>
    <name>A0A0F7NGS6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PPM-type phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_09380</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_09380"/>
    <dbReference type="EnsemblBacteria" id="AKH86639">
        <property type="protein sequence ID" value="AKH86639"/>
        <property type="gene ID" value="AA958_09380"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_09380"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1979"/>
    <dbReference type="Proteomes" id="UP000034283">
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    </dbReference>
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        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="441"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH86639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="682" mass="70356" checksum="5AD4256429EE5ED1" modified="2015-07-22" version="1">MTDVALALAAGMPAAAAARRFVRELLAGRAGPEVDDAELLTSELVTNAVVHAGTDVRVRCRLVTEDATAAGLARDGAAGGGPAAEPTLLVEVTDGHAARVMPLPAPEESYGYGLQLVAALADAWGVEHRRSEKTVWFRMGPLREVADEPAGDPAAAAPRRETGAAHAEGGAHGTGAVPDDAAHGRGVPHHADGSGGDTVRGAHDLADDDPADPHADPHTDPYAAHSAAFRLPSQATAHTPRSATDPELRGGGPWAGVGAFSFLAETSDMLAGQFDEDMVASLATQLLVPRLADWSAVWLEGADGAEPRLAQVWHAAEERISPLRRALEQCPLPPPDARPVPVAWPGGSGGVARGPGDAGSGLGGPALACPLVAGGRRVGTLLFGRAGVARIDGDVVAVVTDFARRVAHAVSAARQYTRQVTISEVLQRGLLPSGIAEMPAMDTAVVYEPAEGAAAGGDFYDLFPSGSDRWCFALGDVCGQGPEAAVVTGLARPVLRLLAREGYGVADVLAGLNRTLVEHAFEAVEAATAFGLPPEQARFLSLLYGELVPYEHGGGGVRCTVASAGHPLPLLLRSDGGVRAAADAQLLLGVLDDAEYYSQSFDLEPGDTLLCVTDGVTERRYGDRLFDDGDGLAEALSCCTGLGAAAVAERIRTAVHDFAPAPPRDDLAMMVLQARGTEPGGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NH77</accession>
    <name>A0A0F7NH77_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_09085</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86633">
        <property type="protein sequence ID" value="AKH86633"/>
        <property type="gene ID" value="AA958_09085"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_09085"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1914"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH86633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="192" mass="21070" checksum="1F445FA3F02827BB" modified="2015-07-22" version="1">MLPPNWSRIPLRDGTDEAIMRIVDEAVADLPDDMPRDRIPQVRLELVRRLRKAAADARKSGGLDLYLPVQQMHGVTVAASFVVSEITLATGADPSLILARLLADAEKSQPAAVDGSVGYRNERVARGSGEEGGEYASRRVDYVLAVPEDDTRWVTVGFSTLADGDPKGQFADVLVELFDALMTTFRWTRSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NH82</accession>
    <name>A0A0F7NH82_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cytidine deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_09305</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019900.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_09305"/>
    <dbReference type="EnsemblBacteria" id="AKH86638">
        <property type="protein sequence ID" value="AKH86638"/>
        <property type="gene ID" value="AA958_09305"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_09305"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1963"/>
    <dbReference type="OrthoDB" id="2043951at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH86638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="116" mass="11764" checksum="0C880CEB012882DB" modified="2015-07-22" version="1">MSESSTLDPEDRKIVTLARSTRARNAVPEGAAVRDETGRTYVAGTVALESLRLTALQTAVAMAVASGATSLEAAAVVTEAEGPADADLAAVRDLGGADTPILLAGPDGEVRSTTRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NHA7</accession>
    <name>A0A0F7NHA7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_10520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_10520"/>
    <dbReference type="EnsemblBacteria" id="AKH86673">
        <property type="protein sequence ID" value="AKH86673"/>
        <property type="gene ID" value="AA958_10520"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_10520"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2216"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_12" evidence="1">
        <location>
            <begin position="274"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="435" mass="46138" checksum="2DD873BC44C2FAFF" modified="2015-07-22" version="1">MLRDTLDGTSRGVLVDSPPGAGKSTLVVRAARELAAAGRRLLLVAQTNAQVDDLVDRLAREEPDLPVGRLHSSDPRPYDPVLDGHEHVRTATSLAGLAGLGVIASTAAKWAYVAAARAKEGDGAERWEHAIVDEAYQMRSDALLSVAGLFERALFVGDPGQLDPFSAVGAEQWSGLAWDPAASAVTTLLAHHPGLPQHRLPVSWRLPASAAPLVSRAFYPFTPFRSGTGPGERRLAFAERSDGSGADRVLDEAAASGWGLLELPAAHTPRTDPEAVAAVARVVRRLLERRGTTASERGEGELTADRIAVGAAHRDQAAAVRAALARTLPAVSADAVTVDTANRLQGMEFDVTVVLHPLSGRPDATAFHLETGRLCVLASRHRHACVVVCRAGVPELLDEHPSTEPVQLGAVVKFPDGWEAHQAVLAHLADHRVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NHD7</accession>
    <name>A0A0F7NHD7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_12470</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019988.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_12470"/>
    <dbReference type="EnsemblBacteria" id="AKH86713">
        <property type="protein sequence ID" value="AKH86713"/>
        <property type="gene ID" value="AA958_12470"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_12470"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2620"/>
    <dbReference type="OrthoDB" id="807474at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005693">
        <property type="entry name" value="Mce"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024516">
        <property type="entry name" value="Mce_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11887">
        <property type="entry name" value="Mce4_CUP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00996">
        <property type="entry name" value="Mtu_fam_mce"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MlaD" evidence="2">
        <location>
            <begin position="49"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Mce4_CUP1" evidence="3">
        <location>
            <begin position="131"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH86713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="390" mass="40560" checksum="DDBD26E626B63955" modified="2015-07-22" version="1">MARPVTGAVRRLRAAGGRLRGRRPVALLVTAAVLVAAGTWGVRALTGPDGKEITAYFDSGVGLYGGSDLRILGVKVGTVDSVEPEGDRVRVGLTLHDGVRAPADVQAAVIAPSVVSGRYVQLSPPYTGGPELADGDEIPVERTATPVEIDELYASLTDLSDALGPDGANATGELSKLLETGARNLEGNGKEIGDSIDRFGDATQTLSGRSGDLFGTIENLQSFTTMLKRNDRQVRDAEQQLADVGTFLAEDKDELAAALEELGTALGRVQGFIKDNRGRLKANVGKLADLTRLLVDNRASLAEALDTAPLATDNLLRAYNPGKRTIDGRGNLNELSMGGPPDAGLADDGGGATGREGLVPAPAERQEELPGLPLPAIGDVYGTPEQGGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NHR7</accession>
    <name>A0A0F7NHR7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AsnC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_33320</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019522.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_33320"/>
    <dbReference type="EnsemblBacteria" id="AKH86297">
        <property type="protein sequence ID" value="AKH86297"/>
        <property type="gene ID" value="AA958_33320"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_33320"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.7037"/>
    <dbReference type="OrthoDB" id="1844486at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019885">
        <property type="entry name" value="Tscrpt_reg_HTH_AsnC-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13404">
        <property type="entry name" value="HTH_AsnC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00519">
        <property type="entry name" value="HTH_ASNC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="3"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH86297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="151" mass="16616" checksum="2B1BCB66E798DFB0" modified="2015-07-22" version="1">MRLDELDERIVRALAEDARRTYADIGAEVGLSAPAVKRRVDRLRAAGAITGFTVRVDPTALGWATEGYVELYCRSNTGPGDIRRALSRYAEVAAASTVTGDADAIVQIFATDMRHFEEVLERIAGEPFVERTRSVLVLSPLVRRYAPDPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NI00</accession>
    <name>A0A0F7NI00_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nucleotidyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_33715</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + spectinomycin = 9-O-adenylylspectinomycin + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:63228"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:146260"/>
            <dbReference type="ChEBI" id="CHEBI:146261"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019589.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86367">
        <property type="protein sequence ID" value="AKH86367"/>
        <property type="gene ID" value="AA958_33715"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_33715"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.7118"/>
    <dbReference type="OrthoDB" id="1607767at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070566">
        <property type="term" value="F:adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024172">
        <property type="entry name" value="AadA/Aad9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025184">
        <property type="entry name" value="DUF4111"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002934">
        <property type="entry name" value="Polymerase_NTP_transf_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13427">
        <property type="entry name" value="DUF4111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01909">
        <property type="entry name" value="NTP_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000819">
        <property type="entry name" value="Streptomycin_3-adenylyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transf_2" evidence="4">
        <location>
            <begin position="18"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4111" evidence="5">
        <location>
            <begin position="142"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH86367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="253" mass="27326" checksum="399695C175D1AB16" modified="2015-07-22" version="1">MGDQVRKVMTLVDDVLGPEVAGAYLHGSAVLGGLRPASDLDVLVVARHSLTDGERRALLDGLLRVSGFTGGLRPVELTVVVEAEIRPWRYPPTGDFLYGEWLREEFETGGPPRPEPMPDLAIVLTMTLAGDHALAGPPPGRLLDPVPYEDVARAATAGIPELLAEAADDTRNVLLTLARIWSTLATGEIRPKDAAAAWALDRLPPEHRPVLEHARELYLGSRYAEESWTAELRAAVRPHTDYVVAGIGKLSGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NJZ4</accession>
    <name>A0A0F7NJZ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_29220</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_29220"/>
    <dbReference type="EnsemblBacteria" id="AKH87107">
        <property type="protein sequence ID" value="AKH87107"/>
        <property type="gene ID" value="AA958_29220"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_29220"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6160"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH87107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="233" mass="24427" checksum="FD801B79644BE681" modified="2015-07-22" version="1">MVAVDDIVIRYGTATAVDRVSLSVAAGEAVALVGPNGAGKSSLVNAVMGLIRPAAGSVTVRGRAALVPEGRQMFPDLDVEDNLRLGAWSLRSRGAKARDTSRVYEVLPDLAGIRRRKAGTLSGGEQQMVAFGRALMADPEVLVVDELSLGLAPKITRALADHLRDLNATRGLAVLLIEQNARLALDLCTRAYVLETGRIRIEGTSAELAESTEVSAAYLGSPAEQPGAEGDQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MZB2</accession>
    <name>A0A0F7MZB2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_04765</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014975.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_04765"/>
    <dbReference type="EnsemblBacteria" id="AKH81620">
        <property type="protein sequence ID" value="AKH81620"/>
        <property type="gene ID" value="AA958_04765"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_04765"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1004"/>
    <dbReference type="OrthoDB" id="1696971at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009097">
        <property type="entry name" value="Cyclic_Pdiesterase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55144">
        <property type="entry name" value="SSF55144"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="200" mass="21654" checksum="545DD037FC8DFBB6" modified="2015-07-22" version="1">MPRARTEPAADAEAGADAEGWPTAPGTTALSVPLPEVDSVVRNWRARYDTAAAHGGTAHVTVLYPFLHRARVDAPVRTALRRLFAGHEPFEVTFARCARFPGVLYLVPEPDDPLRALTKAVVEQWPEHPPYGGLFGDLDPHLTVANGGGDAVHAAIEADLAPRLPVAARVRAVDLVAYDGRRWREWLRFPLGGREPGHGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MZE6</accession>
    <name>A0A0F7MZE6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">5-oxoprolinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_01665</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxoprolinase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014450.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_01665"/>
    <dbReference type="EnsemblBacteria" id="AKH81086">
        <property type="protein sequence ID" value="AKH81086"/>
        <property type="gene ID" value="AA958_01665"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_01665"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.365"/>
    <dbReference type="OrthoDB" id="1018930at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008040">
        <property type="entry name" value="Hydant_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002821">
        <property type="entry name" value="Hydantoinase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003692">
        <property type="entry name" value="Hydantoinase_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045079">
        <property type="entry name" value="Oxoprolinase_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365">
        <property type="entry name" value="PTHR11365"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05378">
        <property type="entry name" value="Hydant_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01968">
        <property type="entry name" value="Hydantoinase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02538">
        <property type="entry name" value="Hydantoinase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydant_A_N" evidence="4">
        <location>
            <begin position="7"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase_A" evidence="2">
        <location>
            <begin position="208"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase_B" evidence="3">
        <location>
            <begin position="695"/>
            <end position="1205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH81086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="1206" mass="127993" checksum="4E7C410A56C2EA34" modified="2015-07-22" version="1">MTAPWQFWIDRGGTFTDVVGRRPDGTLVARKLLSHDPGRYGAHDDAAVAGVRLLLGLGPDEPVPAERVEVVKMGTTVATNALLERKGEPTVLVVTEGFRDALRIAYQNRPLLFERRILKPEALYERVIEVPERVGAHGEVVRALDLDAARAALAEAYRDGYRSAAVVLVHGYRYADHERTVAEEARRAGFSQISCGHEVSPLMKLVPRGDTTVVDAYLSPILRRYVDRVAGELPGIRLQFMQSNGGLREATHFRGKDAVLSGPAGGVVGMVRSSAEAGHDRVIGFDMGGTSTDVSHYAGEFERDFDTRVAGVRMRAPMLSIHTVAAGGGSVLHFDGRRYRVGPDSAGAVPGPACYRRGGPLTVTDANVMLGRVQPQHFPAVFGPGGDQPLDGEAVRRAFTELAETSAAATGDRRSPEEVAAGFLDIAVLNMANAVKKISVQRGHDVTRYALTSFGGAGGQHACAVADVLGISTVVVPPHPGVLSACGIGVAAATAMREQAVEAELTGESMPRIRQVCAELAERAAADLTDEGIPAAAVDTAARVHLRYAGTDSAIAVPLAAEAEMRAEFTAVHRRRFAFTMDKPIVAEAASVEAAAEQAPTTREEVGEAARTGGAPQPADCVRIFTDGQWREAGLFQRAELRADDTVTGPAIIAEEGSTTVVDPGWQAAVHHRGHLTLTRVRPRPATLAVGTGVDPVMLEVFNSLFMAIAEQMGVRLESTAHSVNIKERLDFSCALFDAEGNLISNAPHMPVHLGSMGESIKEVLRRNRDGGHGLRPGDVYAINDPYHGGTHLPDVTVVTPVFDDAGRQLLFLVASRGHHAEIGGITPGSMPAFSRTIQEEGVLFDNWLLVRDGELREAETRRLLTSGAYPSRAPDANLADLRAQIAANNKGIDELRRMIGMFGLDVVQAYTGHVQDNAEESVRRVIAALGDGTYRYETDAGAVIEVAVRVDRDARGAVVDFTGTSPQQPGNANAPSSVVMAAVLYVFRTLVAEDIPLNSGCLKPLDVRIPPGSMLAPEFPAATVAGNVETSQAVTGALYAALGVQAEGSGTMNNVTFGNDKAQYYETVASGSGAGDGFAGADVVQTHMTNSRLTDPEVLEWRYPVRVEEFAVRDGSGGRGRWEGGRGAVRRIRFLEPMTVTLLTGHRRVAPYGMAGGAPGALGHNAMERADGTVEPLKGCDTVEAAAGDALVVETPGGGGYGAPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-08-12" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MZS7</accession>
    <name>A0A0F7MZS7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pyridoxamine 5-phosphate oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_02355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014570.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH81206">
        <property type="protein sequence ID" value="AKH81206"/>
        <property type="gene ID" value="AA958_02355"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_02355"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.505"/>
    <dbReference type="OrthoDB" id="1804797at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019920">
        <property type="entry name" value="F420-binding_dom_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03618">
        <property type="entry name" value="Rv1155_F420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="1">
        <location>
            <begin position="8"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="142" mass="15616" checksum="52169DAE7E657F28" modified="2015-07-22" version="1">MGEKMTGEEWRTFVSAGTRTGKLATVRADGSPHVAPIWFVLDGDDFVFNTGAGSVKGRNLARDGRATLCVDDERYPYSFAVLSGRARLSDDLDEMRRWATVIAARYVDRELAETYGARNAVAGELLVRVTIDKVVSEARVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0B1</accession>
    <name>A0A0F7N0B1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chloride transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_03425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_03425"/>
    <dbReference type="EnsemblBacteria" id="AKH81391">
        <property type="protein sequence ID" value="AKH81391"/>
        <property type="gene ID" value="AA958_03425"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_03425"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.727"/>
    <dbReference type="OrthoDB" id="1786019at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019999">
        <property type="entry name" value="Anth_synth_I-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236">
        <property type="entry name" value="PTHR11236"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00095">
        <property type="entry name" value="ANTSNTHASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="SSF56322"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chorismate_bind" evidence="1">
        <location>
            <begin position="80"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="356" mass="37344" checksum="0AF3135205036152" modified="2015-07-22" version="1">MPRLAPLVRFGGLVASDLRDVTDDPAALDSAGWWAVVAGYEGRTVCARFGDVRPDPHPPAARAHRWRGPGAACWTTSLDRAGYVAGVHRIRERIAAGDVYQVNLCRVLTAPLPGPDQDAADVDALAAVLARGNPAPYAGVVRLPAHGVEVATASPELYLRRAGRAVESGPIKGTGRTAADLTAKDRAENVMIVDLVRNDLGRVCTTGSVTVPALCAVEEHPGLVHLVSTVRGELAPGAGWAELIGATFPAGSVTGAPKSSALRIIDELETVPRGPYCGGVGWVDADRGTGELAVGIRTFWIDRAAPRGPALRFGTGAGITWGSDPEREWRETELKASRLLAVASEAEVTSEGTVRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0F6</accession>
    <name>A0A0F7N0F6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_00425</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH80883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_00425"/>
    <dbReference type="EnsemblBacteria" id="AKH80883">
        <property type="protein sequence ID" value="AKH80883"/>
        <property type="gene ID" value="AA958_00425"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_00425"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.101"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015658">
        <property type="term" value="F:branched-chain amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06581">
        <property type="entry name" value="TM_PBP1_LivM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043428">
        <property type="entry name" value="LivM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30482">
        <property type="entry name" value="PTHR30482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="254"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH80883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="352" mass="35456" checksum="06CB8E92EEA37191" modified="2015-07-22" version="1">MRGAAAAGALVVAAALPFYLDHFWLNLGLLVAASVVGALGLDLLVGHTGQISLAHPFFIATGGYGYTALASDGSGELAGAGWPTALAALGAIVLAGVAGALYAPISARVRGIYLAVASLGLVVLGQHLLLNLTDLTGGYDGRDAPPLNFFGLAFDDGGGDLLGVPFGRVERLWYVALAVAVAAYALYASLRNTRPGRALAAIRGGETAAAAMGVHVPRYKAAAFAIAAAYAGAAGVLLALTLQRLVPSSYEVEMAFSYMAMIVIGGLGSPLGAVLGAAFVTSLPILLRHYSDHLPLLAAEGSGGLSAGVAAQILYGAAVVAVLLFARGGLAGACRAALRPRRRPTATKAGIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0R6</accession>
    <name>A0A0F7N0R6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Amidase</fullName>
            <ecNumber evidence="4">3.5.1.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_04570</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.5.1.4" evidence="4"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014941.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_04570"/>
    <dbReference type="EnsemblBacteria" id="AKH81586">
        <property type="protein sequence ID" value="AKH81586"/>
        <property type="gene ID" value="AA958_04570"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_04570"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.963"/>
    <dbReference type="OrthoDB" id="1239251at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043864">
        <property type="term" value="F:indoleacetamide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="PTHR11895"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="SSF75304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="345"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="Amidase" evidence="3">
        <location>
            <begin position="81"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH81586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="512" mass="53822" checksum="3CCD5717732E7713" modified="2015-07-22" version="1">MTDDTTADRQDGKAAGERGRGARRGDPGAGARAGTAATPAAHPPVHAFRDDALGAHDAVALAALVRDGEVGAGELARAAVERIRLVDPELHAVAVPAFDTYETDGAATGPLAGVPTLLKDNTDYGGLPTGHGSAAFTPHPAPRHAPFTRQFLSTGMTFLGKTRLPEFGFNASTEYEDGEPVRNPWHTSYSPGGSSGGSAALVASGAVPIAHANDGGGSIRIPAACCGLVGLKPTRGRVVANETGRRLPIDMVGDGVLSRSVRDTAAFLAAAERHWRNPRMPPLGLVEGPGTRRLRIGLVAESPTGAPTDAATRAAVAAVATALAGQGHTVETYALPLDGRFEQDFIAYWGMLAFLAGAGGRFVYDRHFDARRMDGLSKGLRSTYVRRMHTTPAFLRRLRRAADEAYDAALTRYDVLLSPVLAHTTPRLGHLSPNVPYEELLNRLRAYVAFTPINNINGGPAISLPAPATEPAPADGLPVGVMLSAAHGDERTLLELAFALEADLPWRRIQDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N115</accession>
    <name>A0A0F7N115_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glutamate--cysteine ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_01510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014424.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_01510"/>
    <dbReference type="EnsemblBacteria" id="AKH81059">
        <property type="protein sequence ID" value="AKH81059"/>
        <property type="gene ID" value="AA958_01510"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_01510"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.331"/>
    <dbReference type="OrthoDB" id="367541at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016602">
        <property type="entry name" value="UCP012666"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF012666">
        <property type="entry name" value="UCP012666"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH81059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="497" mass="55426" checksum="F8190F6004CD9D61" modified="2015-07-22" version="1">MGEKVVAGGFDLSDRRRYRQRLRECLVGLERLLEEKRFDRPQNLMGLEIELNLVGADGMPQMMNTEVLERIASPDFQTELAQFNLEVNIAPHRLAGRVLDQLAEELRTGLWYADRQAREVGAGIVMIGILPTLTAADLVSGNLSEVDRFHRLNEQILAARGEEIHLDLRGVEELTYTTGSIASEAACTSVQMHLQVTPSRFADVWNASQAAAAVQVALGANAPFVFGRELLSESRPELFLQATDTRPPEYRAQGVRPRVWFGERWITEPLELFEENLRYFPSLLPLCSAEDPLRVLDEGGVPELSELVLHNGTVYRWNRPVYDLAGGVPHLRVENRVLPAGPTVTDVVANAAFYYGLVRTLADEQRPVWGRLPFDGAAANFAAACRDGIDATLVWPGRRRLGGVARVPVAKLVRDELLPMAASGLDAWGVDPADRDRYLGVIEERCRRRVNGASWQAAAFHRALGRGLDRGAALAEMTRRYVELTRTEEPVHRWPAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N116</accession>
    <name>A0A0F7N116_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_08760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015652.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_08760"/>
    <dbReference type="EnsemblBacteria" id="AKH82305">
        <property type="protein sequence ID" value="AKH82305"/>
        <property type="gene ID" value="AA958_08760"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_08760"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1848"/>
    <dbReference type="OrthoDB" id="578966at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040871">
        <property type="entry name" value="HopA1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17914">
        <property type="entry name" value="HopA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH82305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="326" mass="34076" checksum="78E3821BB8872234" modified="2015-07-22" version="1">MTHADNPLPGGIKDALCRVTVRRGGRSALAWGEELVAEGPIHLRTLLQLAVYERLHAGLALGPETWMSGARRDAVVESRLLAAMPHRDTVVRARPAEWRAGELLADIGGVRVRVPAERVRGEADEGRVSVALPAARPALSPGYFLADGSRGGPRGTPLLRVYVHLDAAEAVPAVWSAVLRCLEDREVPYRAKVSSSSAFLPRRDGLVVYLGPADWSAAVDVASSSAGLPGQGADVSAFAAQLAPGAAVAWEPPAAEGAGRRLSFGEHRAMAVATGLMEHALGGGEAPKADAVAAALRGAGIDPRAPYRNLDSPPLDFLAVDTPPAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N199</accession>
    <name>A0A0F7N199_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_05810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015149.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH81796">
        <property type="protein sequence ID" value="AKH81796"/>
        <property type="gene ID" value="AA958_05810"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_05810"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1216"/>
    <dbReference type="OrthoDB" id="1518964at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH81796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="157" mass="17650" checksum="E953D33362AFEA87" modified="2015-07-22" version="1">MAIPEVIPIRHEPGYRTENIGRYDHGQFLASITAAYPPDYRMGPDWLEHRRWYAVLHRFDAEGHHTGSDIWTPGPGVPADGRMDAKMEGWLDELPGLVFGDIAIRPFEVSVDGIRFGLVAERHAEPAAGAGGDEPDWAELYPDRLGFHEPWDGLYDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N1E7</accession>
    <name>A0A0F7N1E7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycine--tRNA ligase</fullName>
            <ecNumber evidence="7">6.1.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Glycyl-tRNA synthetase</fullName>
            <shortName evidence="7">GlyRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">glyQS</name>
        <name evidence="9" type="ORF">AA958_09180</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the attachment of glycine to tRNA(Gly).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly)</text>
            <dbReference type="Rhea" id="RHEA:16013"/>
            <dbReference type="Rhea" id="RHEA-COMP:9664"/>
            <dbReference type="Rhea" id="RHEA-COMP:9683"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78522"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.14"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.14" evidence="7"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015716.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_09180"/>
    <dbReference type="EnsemblBacteria" id="AKH82370">
        <property type="protein sequence ID" value="AKH82370"/>
        <property type="gene ID" value="AA958_09180"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_09180"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1936"/>
    <dbReference type="OrthoDB" id="626850at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004820">
        <property type="term" value="F:glycine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006426">
        <property type="term" value="P:glycyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00774">
        <property type="entry name" value="GlyRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00253_B">
        <property type="entry name" value="Gly_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027031">
        <property type="entry name" value="Gly-tRNA_synthase/POLG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022961">
        <property type="entry name" value="Gly_tRNA_ligase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033731">
        <property type="entry name" value="GlyRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002315">
        <property type="entry name" value="tRNA-synt_gly"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10745">
        <property type="entry name" value="PTHR10745"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01043">
        <property type="entry name" value="TRNASYNTHGLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00389">
        <property type="entry name" value="glyS_dimeric"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="8">
        <location>
            <begin position="7"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="209"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="321"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="194"/>
            <end position="196"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="204"/>
            <end position="209"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="281"/>
            <end position="282"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="325"/>
            <end position="328"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH82370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="460" mass="52179" checksum="E76CA1760327610D" modified="2015-07-22" version="1">MAADKIDTIVSLSKRRGFVYPCSEIYGGQRAAWDYGPLGVELKENIKRQWWRSMVTSRDDVVGLDSSVILAREVWEASGHVATFTDPLTECTSCHKRYRADHLEETYEAKHGHPPTGGLADINCPHCGNKGGFTEPKQFSGLLATHLGPTQDAGSETFLRPETAQGIFTNFMQVQTSSRKKPPFGIAQTGKSFRNEITPGNFIFRTREFEQMEMEFFVKPGEDETWHEYWMQQRWNWYTGLGMQETNLRWFEHPKDKLSHYSKRTVDIEYRFDFAGSQWGELEGIANRTDFDLKAHSAASGQDLSFFDQEAGERWTPFVIEPAAGVGRTMLAFMLDAYVEDEAPNAKGKMEKRTVMRLDPRLAPVKAAVLPLSRNPELSPKAKGLAADLRGHWNIEFDDAGAIGRRYRRQDEIGTPYCITVDFDTLDDNAVTVRERDTMKQERVSLDQVGTYLGGRLLGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N1G5</accession>
    <name>A0A0F7N1G5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3'-5' exonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_02830</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014646.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_02830"/>
    <dbReference type="EnsemblBacteria" id="AKH81283">
        <property type="protein sequence ID" value="AKH81283"/>
        <property type="gene ID" value="AA958_02830"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_02830"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.605"/>
    <dbReference type="OrthoDB" id="461084at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001098">
        <property type="entry name" value="DNA-dir_DNA_pol_A_palm_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002298">
        <property type="entry name" value="DNA_polymerase_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10133">
        <property type="entry name" value="PTHR10133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00476">
        <property type="entry name" value="DNA_pol_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00868">
        <property type="entry name" value="DNAPOLI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00482">
        <property type="entry name" value="POLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POLAc" evidence="2">
        <location>
            <begin position="313"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="432"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH81283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="556" mass="59533" checksum="2142F8218518747B" modified="2015-07-22" version="1">MRWAMADGPRGGVIVCPVDAAGDPQGPEHTYPHPAHALRHHPTADRWIWSSTAAFYPRLLDAGETVPRCHDVEAAEAILLGHEGMWGLPRSLAAAWARLRGLPVPKDPPPRSFAGEPQPTLFDAAPARPHGTDDLPALLAVHAAQQDRVAASAHPHRLRLLLAAESAGMLVAAEMHHAGLPWRADVHDALLTELLGGRYPGGLEPPRLAALADDVSRAFGERVRPDLPAEVVRAFRKAGVRITSTRKWELQDIDHPAVAPLLEYKKLYRLHTAHGWSWLQTWVHGGRFRPEYLPGGAMSGRWTTHGGGALQIPRVVRRAVVADEGWRLVVADADQMEPRVLAAVSGDAGLMAAADGTRDLYEALAARAFAGGRAEAKLALLGAIYGQTSGDALTYLADLRRRFPAAVAYVDEAARAGEEGRLVRSHLGRTCAPSEAADDGEAGLPQEDDGGGAAARGGAAARARGRFTRNFVVQASAAEWALCLLAALRQELAGMRAELVFFQHDEVIVHCPEAEAPAVEKALAVASARAGEVMFGQTPVVFSFTTAVVECYADAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N1M2</accession>
    <name>A0A0F7N1M2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Imidazoleglycerol-phosphate dehydratase</fullName>
            <shortName evidence="5">IGPD</shortName>
            <ecNumber evidence="5 6">4.2.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">hisB</name>
        <name evidence="7" type="ORF">AA958_06385</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:11040"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57766"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="EC" id="4.2.1.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 5 6">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 6/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the imidazoleglycerol-phosphate dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.19" evidence="5 6"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015249.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_06385"/>
    <dbReference type="EnsemblBacteria" id="AKH81896">
        <property type="protein sequence ID" value="AKH81896"/>
        <property type="gene ID" value="AA958_06385"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_06385"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1333"/>
    <dbReference type="OrthoDB" id="1278103at2"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00011"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004424">
        <property type="term" value="F:imidazoleglycerol-phosphate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07914">
        <property type="entry name" value="IGPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00076">
        <property type="entry name" value="HisB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038494">
        <property type="entry name" value="IGPD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000807">
        <property type="entry name" value="ImidazoleglycerolP_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020565">
        <property type="entry name" value="ImidazoleglycerP_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23133">
        <property type="entry name" value="PTHR23133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00475">
        <property type="entry name" value="IGPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00954">
        <property type="entry name" value="IGP_DEHYDRATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00955">
        <property type="entry name" value="IGP_DEHYDRATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 6" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="4 5 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH81896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="197" mass="21511" checksum="47252C928197DC28" modified="2015-07-22" version="1">MTRVGRVERTTKETSVVVELNLDGRGEVSVSTGVGFFDHMLDQLGRHGLFDLTVKTDGDLHIDSHHTMEDTALALGAAFRQALGDKRGIVRFADASVPLDESLAQVTVDLSGRPYLVHTEPEGMAPMIGADYDTTMTRHILESFVAQAQIALHVHVPYGRNAHHIVECQFKALARALRYAAEIDPRQTGIPSTKGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N1X5</accession>
    <name>A0A0F7N1X5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH araC/xylS-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_00225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH80852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_00225"/>
    <dbReference type="EnsemblBacteria" id="AKH80852">
        <property type="protein sequence ID" value="AKH80852"/>
        <property type="gene ID" value="AA958_00225"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_00225"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.52"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035418">
        <property type="entry name" value="AraC-bd_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14525">
        <property type="entry name" value="AraC_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="213"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH80852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="341" mass="37492" checksum="D37C1F3546B72AA1" modified="2015-07-22" version="1">MGWPEMHTATVPKAERFGWWRDLLMQDLPSAHIVSEHYEDFQGSTAALELGPIRVSVLSFSPLSSARTAGLIRRSDPELWELGYMTRGIMTVDQAHSHTQVGAGDLLLYDTSQPWQMQVPQGGGLTILHLPKTAVPLPDRSMRDLLSRRLPVQGTGSLLAGFLQGLAGGGQWSELEAERLGAAAVQLASAFLGGLADREGLLPLETRQTVLLREVKAFIEAHLPEPRLSPQTIADAHCISVRYLHQLFRSEKQTVSALIRDLRLDRCRTDLAQPCYAHCPVAAIGARWGFSDAAMFSRAFKSAFGMPPGEYRKWSGTRRSAGDHPDGFAGPASLYDLRDLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N200</accession>
    <name>A0A0F7N200_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Thiamine biosynthesis protein ThiS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_10730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015961.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_10730"/>
    <dbReference type="EnsemblBacteria" id="AKH82620">
        <property type="protein sequence ID" value="AKH82620"/>
        <property type="gene ID" value="AA958_10730"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_10730"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2257"/>
    <dbReference type="OrthoDB" id="1995573at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003749">
        <property type="entry name" value="ThiS/MoaD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02597">
        <property type="entry name" value="ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="SSF54285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH82620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="92" mass="9975" checksum="FC9B1E87AEB923CF" modified="2015-07-22" version="1">MAIEVRIPTILRSYTDGEKAVEGDGTTLAELIDDLESRHTGIRARLVDGDDLRRFVNVYLNDEDVRFLDGIATKLTDGDSVTILPAVAGGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N259</accession>
    <name>A0A0F7N259_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Beta-N-acetylhexosaminidase</fullName>
            <ecNumber evidence="3">3.2.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_11090</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="3"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_11090"/>
    <dbReference type="EnsemblBacteria" id="AKH82685">
        <property type="protein sequence ID" value="AKH82685"/>
        <property type="gene ID" value="AA958_11090"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_11090"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2335"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004563">
        <property type="term" value="F:beta-N-acetylhexosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102148">
        <property type="term" value="F:N-acetyl-beta-D-galactosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025705">
        <property type="entry name" value="Beta_hexosaminidase_sua/sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015882">
        <property type="entry name" value="HEX_bac_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600">
        <property type="entry name" value="PTHR22600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02838">
        <property type="entry name" value="Glyco_hydro_20b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00738">
        <property type="entry name" value="GLHYDRLASE20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="SSF55545"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_20b" evidence="7">
        <location>
            <begin position="22"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_20" evidence="6">
        <location>
            <begin position="154"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH82685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="559" mass="61694" checksum="94339BF2FEC609FA" modified="2015-07-22" version="1">MEPFIWSGERQRQPVERRPTLIIPTPSRSSPRPGSYALGPDTPLHVADPALAPVARVLREQLLPGTGCTLPPGRGGIELALSGELAADPGAGPESYRLTIGPDGIRIAAGGPAGAFYGVQTLRQLLPPHTLRHSALDEGPWDLAGVEIEDRPRFAWRGVLLDVARHFFTKRDVLRVLDQMALHKLNVLHFHLTDDQGWRLEVKRYPRLTEVGSWRTESKPGWNETGDGRPHGGYYTQDDIREIVAYAAARHILVVPEVDVPGHTQAAITAYPELGNTGAQLAVETGWGVKSNILSVSDGTLDFVRNVFDEVIELFPSPIICVGGDECPKDQWKASPAAQARMAELGLRNEDELQSWFIRQVSDHLEARGRQLLGWDEILEGGLPPAATIVSWRDNHGAVRAAREGHQVITSPARQVYLDYRASDSPDEPVPVGTVLPVEEVYAFEPVPEELRGTPAADLVIGAQCGLWTEAIDNARALDYQAFPRMSAFAETVWCDATRDGTAFAERLAHHLGRLEALGVEYRRPEGPRPWERRPGVRGRPVTMEEYLAEVEADTRNIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2N9</accession>
    <name>A0A0F7N2N9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cobalt ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_12155</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_12155"/>
    <dbReference type="EnsemblBacteria" id="AKH82865">
        <property type="protein sequence ID" value="AKH82865"/>
        <property type="gene ID" value="AA958_12155"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_12155"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2557"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03225">
        <property type="entry name" value="ABC_cobalt_CbiO_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015856">
        <property type="entry name" value="ABC_transpr_CbiO/EcfA_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="12"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="45"/>
            <end position="52"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH82865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="252" mass="26974" checksum="B05BA9115D81F6D4" modified="2015-07-22" version="1">MDSPMTLLPPSLEVTGLAYAYPDGHQALFGVDLTVERGERVAVLGPNGAGKTTLVLHLNGILGGGAGTVRVAGLPVEKRNFAEVRRRVGIVFQDPDDQLFMPTVRDDVAFGPAAGGMRGPELEACVRRALEQVGMADHADRPPHHLSFGQRRRVAVATVLAMEPEVLVLDEPSSNLDPAARRELADIVRSLDVTVLMVTHDLPYALELCPRSVVLGGGLIVADGATKELLLDEELMAAHRLEIPFGFDPGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2Y4</accession>
    <name>A0A0F7N2Y4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">AA958_09025</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015693.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_09025"/>
    <dbReference type="EnsemblBacteria" id="AKH82346">
        <property type="protein sequence ID" value="AKH82346"/>
        <property type="gene ID" value="AA958_09025"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_09025"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1902"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 8" id="KW-0853">WD repeat</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="386"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="40"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="445"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="564"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="621"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="313"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AKH82346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="749" mass="77287" checksum="95090FFBC76CEFD0" modified="2015-07-22" version="1">MSRPDESAVPHGRTGDAGWSAVAPPHLPLGAADPAVAGPYRLEAVLGAGGMGRVYLGRTPAGSAVAVKLVHREYAGDAAFRQRFAQEVAAARRVQGLYTVPVVDADLQADEPWLATAYVPGPSLQHAVAESGPLPADAALALIARVAEALQSIHAADVIHRDLKPSNILLTDDGPKVIDFGIARAADLTAVTATGVRTGTPAYMAPEYIRGQTVTEAGDIFALGGVAHFAATGGHAFGGGTDHGVVYRILEQEPDLDGSPEPVRAVAAACLAKDPERRPTPAEVIELCRLAAAAGAGGHPATVLAVPAPGTSPGVAGPAVASGPGDAERTVSARPTALDEAGTPPAGPAAPAAPGPHDLATRTAAAPAAPGTVPRPPDPDARTGTLAPLALLIGGAVAVVLVLVLIAVFLPSGDPGKPQADSPYDTYEPTGTLAFPARAAGPAGIDFSPDSETLATVGDDGKIRLWDVARRKQRAAFTQDDEAGNVFGVGTVTYSPDGKLLATGLPTGQTGLWDVAKRRPLNYLHMGGESLAFSPDSKLLAIGSRTGSVYLFDPAERSDDIVAYFDHRSDVTALAFSPDGRTVASAGDDSESNSGRNDTTQLWNVAKLDPQPHGQDGPRKILDQPREATAAAFSPDSRTLAVGHPDGEVWLWDVTTGREKGMLRNDYLTAVADLEFSPDGKTIATTTALGGGVLLWNVADRMPRALLETGEEDEEGKGAVEEVTFSPDGKLIAGADRKDGAVRLWRDPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3A3</accession>
    <name>A0A0F7N3A3_9ACTN</name>
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        <submittedName>
            <fullName evidence="5">Histidine kinase</fullName>
        </submittedName>
    </protein>
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        <name evidence="5" type="ORF">AA958_13855</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="AKH83140.1"/>
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AKH83140">
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        <property type="gene ID" value="AA958_13855"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_13855"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2917"/>
    <dbReference type="OrthoDB" id="1827824at2"/>
    <dbReference type="Proteomes" id="UP000034283">
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HATPase_C"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
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        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HIS_KIN"/>
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    </dbReference>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="33"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="161"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH83140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="382" mass="39721" checksum="B5CC32F616CF9167" modified="2015-07-22" version="1">MNDILLMAAFAFLGAAVAGLLGAVALRLLRNRSLVVSVSVVAATAVTAMLLGTLAVAREMFLSGHDLTVVSIVCLMAAVVSLATAVLLGRWVVARSNALAAATRSFGHAFDAGGSFAPPAGGATAELAALSRELAATAERLAQSRQRERALDASRRELVAWISHDLRTPLAGLRAMAEALEDGMAADPGRYHRQIRAETERLDAMVGDLFELSRIHAGALALAPTRMSVHDLVGDALAGADPLARERGVRLVGEPPEPAAAVPVEVDGKEMTRVLGNLLVNAIRRTPADGTVAVTVAVREREGPAVVVSVTDQCGGIPEEDLARVFDTGWRGNHARTPVPPAGAGLGLAIVRGIVEAHRGRAEVRNVPGGCRFEVTLPAATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3C3</accession>
    <name>A0A0F7N3C3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_06215</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015222.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_06215"/>
    <dbReference type="EnsemblBacteria" id="AKH81869">
        <property type="protein sequence ID" value="AKH81869"/>
        <property type="gene ID" value="AA958_06215"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_06215"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1300"/>
    <dbReference type="OrthoDB" id="1387978at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="82"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="3">
        <location>
            <begin position="141"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH81869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="348" mass="36475" checksum="CE99B144A686609C" modified="2015-07-22" version="1">MKQPDPADTSNTPDTPDAPDAAATPRPRTPPLRRAARALRRPAPWRRGLVLAALALLLGLVMALHARVPSGIMNLGSFTETFLPWFGLCVLPLLAGALWRRSASAVVALVLPVTVWLSLFGGLLTDKSRPGSDLTVAGHNVGAANPDPAGTARDLAASGADLLALQELTDTARPVYEAELAKTYPHHTTSGTVGLWSKLPLSATRPVDIAMYPSRALRTTVATERGPLAVYVAHLGSVRVNLRAGMSTAQRDAGAEALAAAVAAEPTGRVVVLGDLNGTVDDRAFDALTGQMRSVQEEAGNGFGFSWPAGFPVARIDQILVRGVEPRSAWLLPATGSDHLPVAAGIAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3U8</accession>
    <name>A0A0F7N3U8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF2201_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_07090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015373.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_07090"/>
    <dbReference type="EnsemblBacteria" id="AKH82023">
        <property type="protein sequence ID" value="AKH82023"/>
        <property type="gene ID" value="AA958_07090"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_07090"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1486"/>
    <dbReference type="OrthoDB" id="278539at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025154">
        <property type="entry name" value="Put_metallopeptidase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13203">
        <property type="entry name" value="DUF2201_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2201_N" evidence="2">
        <location>
            <begin position="248"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH82023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="633" mass="68696" checksum="0A2FD2DC2F264C69" modified="2015-07-22" version="1">MSRTNRAAGRRGKAKAQQRDDPATRAFSAGLAKAMQNPALRALGAQVVRKGAAGTGAAPHSTGGTTIVSGTADTPAPAHGLARVDSYGTVHAHPTRRAEPAEWTWALAHCLLHLGFGHAPAARGERTQPDRYEQAARCTVVNRFLLSFGTGRPPADLPAHYPGGGEEELAARWRRDGIPPEYERCGAAGDEPDVLLLPWDGWPGTTPPDWQKDFAHALARTMSAAMEVAGGRRDSLTGARAPRRPWERALEWFVSSYPLLGGIAAGMTVVADADLARAHDISVAAVDAAAGEIYVNPLKDHSDEEWRFILGHEMLHAALRHGERRGARDPYLFNIAADFVVNGWLLEMRVGEMPAGLLHDPRLAGLSTEEVYDRLAADLRVQRRRLATPRGRGLGDVLGEPLVPRDPAAAYVDLDEFYRRGLQRGLDLHERDQDRGLLPAGLIEEIRALAQPPLPWDALLARWFDEFVPRAEPVRTFARPARRQAATPDIPRAGRYFPPEEVARCTFGVVLDTSGSMSRTLLGKALGAIASYAEARDVPAARVVFCDAMPYDAGYLPPTEIAGRVRVKGRGGTVLQPGLDLLERADDFPGAAPVLVITDGMCDVLRVRREHAYLIPAGASLPFVARGPVFRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N441</accession>
    <name>A0A0F7N441_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_15695</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016722.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_15695"/>
    <dbReference type="EnsemblBacteria" id="AKH83410">
        <property type="protein sequence ID" value="AKH83410"/>
        <property type="gene ID" value="AA958_15695"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_15695"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3308"/>
    <dbReference type="OrthoDB" id="1828335at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd08545">
        <property type="entry name" value="YcnI_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012533">
        <property type="entry name" value="YcnI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038507">
        <property type="entry name" value="YcnI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07987">
        <property type="entry name" value="DUF1775"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519761" evidence="2">
        <location>
            <begin position="25"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1775" evidence="3">
        <location>
            <begin position="25"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH83410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="258" mass="26106" checksum="5E463427F9268F83" modified="2015-07-22" version="1">MRRMSVSTAVAAGTVLILAGPAAAHVSVDPGEAEQGGYATVSFKVPNERDNASTIKLEVTLPTDHPLTSVMPEPVPGWDVKVEQAELDTPIESHGEKITEAVSKVTWSGGKVEPGTFQRFPVSMGALPEDADQLVFKAVQTYDNDEVVRWIEVPGEGAEEPESPAPVLALTPAEDGGHGGADDDDADDAGNGDDAEPAAAEGESSEDSAADDDGSSDTMARTLGIVGIVLGAGGVAFGVLSRRGAGSGGGAGGSSAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N478</accession>
    <name>A0A0F7N478_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AMP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_08025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015538.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_08025"/>
    <dbReference type="EnsemblBacteria" id="AKH82188">
        <property type="protein sequence ID" value="AKH82188"/>
        <property type="gene ID" value="AA958_08025"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_08025"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1693"/>
    <dbReference type="OrthoDB" id="961884at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="37"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="539" mass="58696" checksum="0AF1494FA9D3AB4E" modified="2015-07-22" version="1">MKKAPRPKNLGGLLESYAGAETPQWNLDRPFDIAPDGGREYDVSGLARLVADMSGRLREAGLRRGDRLAIVKENHHDVVLLAAAAARIGALPAMISTSIAPATLATMMERFDPRVFIASDSVLAAAAAADVTMTGEKTQVVAIEGDTSLAPGSLALADLAGADVPPMDLRADDEPMICTHTSGTTGVPKLVAHSANTLIGVLTKLETLPIPGLAVRKDDVFASCIAFVHGRAITWTYAQLARPPKKVVVLGGSEPRLVAETLKEHRPTVLETCPNLYQRWEPLTESDPEAFSRIRAYLNTFDAIHPSTVRKFMEASRRSRPVWGQVWGQSETGPVAMALYSRNKIRKNAGALNPVTSNVGRPVPFVTRIKLADPETRKPVARGEQGLVLVRTKGLCLTYLGEDERHREKKWDGWWNTGDIGVRSRTGLLRILDREVDVIPGTSGIELESILLERLKRSTEVIVLGNPGGLPVPVISLSGGSTLGKEEWSEATEGLPELAEPKIIDWDEFPRTGTWKVRRFDLRQQVLGSQATYGSGRWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4C8</accession>
    <name>A0A0F7N4C8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GDE_N_bis domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_08345</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_08345"/>
    <dbReference type="EnsemblBacteria" id="AKH82238">
        <property type="protein sequence ID" value="AKH82238"/>
        <property type="gene ID" value="AA958_08345"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_08345"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1761"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032856">
        <property type="entry name" value="GDE_N_bis"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14742">
        <property type="entry name" value="GDE_N_bis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GDE_N_bis" evidence="2">
        <location>
            <begin position="24"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH82238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="687" mass="73924" checksum="E474C1862E2E28C7" modified="2015-07-22" version="1">MLTDWIPQPFIHDAIICVGAPELVLSPRDGQIRGGAEGFYAADSRLISRLVLSVNGQEPEIVDAWLSHAGEAHFLAVHRDGDDPTPDPTVTVERVRTAGRDFERITVSNHRRRDVRLALRLSTACDLSDMSEVRAGRPREARPATESGRSIVWTSPGKGAVTLTGTPAPDRVEAGRHAAAFVWDVELAPAQTWTTTLALDTTPGTVSAPPAAVVAPRPGRQPWSAPRLTCTDPRLTRLIDQSLNDLAALLLADPQARDDRFLAAGVPWYLTLFGRDSLWAARMMLPLGTELAAGTLRSLARRQGTTHDAATEEQPGKIMHELRREASAVLPPLYYGTIDATLLFVTVLAEAWHWGMPESEVAALLPAAERALDWLREHADADGDGFVEYARLRETGLVNQGWKDSEDAVQSTAARLAKPPIALAEVQGYAYEAARAGAQLLTAFGRPGADYWREWAEQLAGRFRSAFWLEDDLGPYVAIALDGQKRPVDAVASNMGHLPGTGILSQEECRLVARRLSRADMDSGWGLRTMSANARGFNPFGYHTGSVWAHDTAIAVAGLAATGNHQAAASLMDGLVEAASAFDYRLPELYAGEQRRAGGRPAPYPASCRPQAWAATAGVSLLTSLLGLRPDLPAGRIRMRPLTASPVGALEVSGIRLGSSSVTVTVDGRGHGDIVGLPLETRVETGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4I1</accession>
    <name>A0A0F7N4I1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome B561</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_05610</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015116.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_05610"/>
    <dbReference type="EnsemblBacteria" id="AKH81762">
        <property type="protein sequence ID" value="AKH81762"/>
        <property type="gene ID" value="AA958_05610"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_05610"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1175"/>
    <dbReference type="OrthoDB" id="1135592at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016653">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006784">
        <property type="term" value="P:heme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003780">
        <property type="entry name" value="COX15/CtaA_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02628">
        <property type="entry name" value="COX15-CtaA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="253"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH81762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="327" mass="34897" checksum="67EEAB657980159F" modified="2015-07-22" version="1">MQNPLALIAERWTPTQKTVQRATLSALLMSIVIVVTGGAVRLTGSGLGCDTWPKCSNDSLLATSEMGVHGAIEFGNRLLTYVLCAAVGWAIVAARATKPWRRELTRLGWVQFWVVMGNAVLGGAAVLTELNPYTVAAHFLLATGLITITYLTWHRAREGDGGPDLLVGAVVRRLTRALVAVSVLLLAAGTVVTGTGPHAGDSSDVPRMGWISWDHAAKVHSFTAWTVVALTIAIWVTLKLVDGPPGPLSRTRDLFWVLMSQAVVGYAQYLTDVPEFLVMIHLFGSTLVWIAVLRVAVSLRHRPEVAPAASPSAATPAEVRPVGSTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4L5</accession>
    <name>A0A0F7N4L5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_08915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_08915"/>
    <dbReference type="EnsemblBacteria" id="AKH82328">
        <property type="protein sequence ID" value="AKH82328"/>
        <property type="gene ID" value="AA958_08915"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_08915"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1877"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042925">
        <property type="term" value="F:benzoate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004711">
        <property type="entry name" value="Benzoate_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30199">
        <property type="entry name" value="PTHR30199"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03594">
        <property type="entry name" value="BenE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00843">
        <property type="entry name" value="benE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="261"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="297"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="327"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="359"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="396" mass="39696" checksum="F167CB2BB4BDEA0D" modified="2015-07-22" version="1">MTPDAAPAAKRRPALTVSTVVAGVVVVVVSYTGPVAVVLHAARAGDLTAGQLESWLWALSLGSGVTCVLLSLAYRAPVLTAWSTPGAALLVTALTTHSFAEATGAYVIAAVLTVLLGLSRLFGALLRLLPPEVAAATLAGILLEFGLRLFRTAEGDLTLVVLMLGAYLAGRRFAASWATACALLTGCAWTAATGDFGTWSGEVGVAVPAFTAPEFTLDAAVGIALPLFLVTMASQNAPGLAVLNAAGYRPDADRLVTSTGAAWLVLAPFGAHGINLAAITAAICSGPSAHPDPERRYGAGVAAGVGYVVVGVFGSAFLGLFAVLPAALVAAIAGIALLGATGGALAAATRDASRLDSALVAFLVTASGIELLGVGAAFWGLLAGVLTHLALHRRAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4S7</accession>
    <name>A0A0F7N4S7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hydroxybenzoate hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_17210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016964.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_17210"/>
    <dbReference type="EnsemblBacteria" id="AKH83660">
        <property type="protein sequence ID" value="AKH83660"/>
        <property type="gene ID" value="AA958_17210"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_17210"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3619"/>
    <dbReference type="OrthoDB" id="1770293at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="2">
        <location>
            <begin position="14"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="405"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="410"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH83660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="425" mass="45981" checksum="354FD2E6F8C8596A" modified="2015-07-22" version="1">MSGTSTTAGPRRLRTQVAVVGAGPAGLVLANVLLRAGVGVAVVERRSRAEVERRARAGLVEHRVVEYLRAHGLAGRLLAEGTRHGWCDFLCAGRLLRFDYGAQSGGIRHWVYPQQLLVRDLIADLGTAGHTPEFGLPATRVHVDGAGPARVECPGLDIECDYVVGCDGPHGITPQALPPDTAPRAELDERYPYDWLTLLAEVDRGVPGVVYAVHEDGFAGVMPRTSRIARLYLEIPAGDATARWTAARVHERLRTRLVGAGAAVPRLGRIVETGVLRMRSSVRQRFQHGRLFLAGDAAHVLTPSGAKGMNLAVADAADLADALIRRYRDGDETHLAGYTARRLPEVLRTRDLAAGFLDLLHPQGEHPADRRGELARRLERLRELAEPGPAGAAFAHWYVGAGPGLPVPHSTPHTMQSREPRESTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4T8</accession>
    <name>A0A0F7N4T8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_17275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016974.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH83670">
        <property type="protein sequence ID" value="AKH83670"/>
        <property type="gene ID" value="AA958_17275"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_17275"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3633"/>
    <dbReference type="OrthoDB" id="1573721at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="9"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="240" mass="24911" checksum="91C6A2E330B84C1A" modified="2015-07-22" version="1">MSNRKQPTVVLVHGAFADGSSWNGVVDKLRRAGYPVVAPANPLRGLRSDAAYLRDVLDSVEGPVVLAGHSYGGSVISEAAAGNDKVKALVYVAAFLPDEGESAAELSGKFPGSTLGETLKEVPTALPDGGAVTDLSIDQDKFHGQFAADVPPVTAQRMAATQRPITSAALGEGAGAAAWRTVPSWALLTTEDKNIPVAAQRFMAERAGARTVTLDASHAVTVSRPDAVADLIEEAARSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4T9</accession>
    <name>A0A0F7N4T9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosomal silencing factor RsfS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rsfS</name>
        <name evidence="3" type="ORF">AA958_09470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Interacts with ribosomal protein L14 (rplN).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the Iojap/RsfS family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015762.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_09470"/>
    <dbReference type="EnsemblBacteria" id="AKH82418">
        <property type="protein sequence ID" value="AKH82418"/>
        <property type="gene ID" value="AA958_09470"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_09470"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1997"/>
    <dbReference type="OrthoDB" id="1990650at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:mature ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090071">
        <property type="term" value="P:negative regulation of ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PTHR21043"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00090">
        <property type="entry name" value="rsfS_iojap_ybeB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="2" id="KW-0810">Translation regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH82418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="143" mass="15711" checksum="DAE474E8F979A3B1" modified="2015-07-22" version="1">MTATDRSIDLVSTAAQAAADKLAHDIVAYDVSDVLAITDAFLLASAPNDRQVKAIVDGVEEALLKERGAKPVRREGERDGRWVLLDYSDIVVHVQHSEERVFYALERLWKDCPELDLPPDAVATRGRAAEYAEAHGDGARRDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4Z4</accession>
    <name>A0A0F7N4Z4_9ACTN</name>
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        <submittedName>
            <fullName evidence="3">DNA mismatch repair protein MutT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_13540</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_13540"/>
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        <property type="protein sequence ID" value="AKH83086"/>
        <property type="gene ID" value="AA958_13540"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_13540"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2849"/>
    <dbReference type="OrthoDB" id="1308416at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="10"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH83086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="147" mass="15897" checksum="7460C4ADD5D6326F" modified="2015-07-22" version="1">MKEHPAHPAPPIRAAGCVLWRTAPGVPGGLEIALVHRPKYDDWSHPKGKLKQGEEPLAAAVREVAEETGMACEPGAPLPTTRYRVADGRPKEIRYWAARAAAGTFVPSREVDRVVWLPPAAARHRLTQGHDRALVDALLATLPSEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N517</accession>
    <name>A0A0F7N517_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_06415</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015255.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_06415"/>
    <dbReference type="EnsemblBacteria" id="AKH81902">
        <property type="protein sequence ID" value="AKH81902"/>
        <property type="gene ID" value="AA958_06415"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_06415"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1340"/>
    <dbReference type="OrthoDB" id="1926714at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
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        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="16"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="54"/>
            <end position="61"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH81902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="331" mass="35449" checksum="AFC63F2AF5F08DCB" modified="2015-07-22" version="1">MRALVKTYPAPRERRRRRRDAERPASSTSPAGPVRASDGVELDIHAGEIFGLLGPNGAGKSTLVRQLTGLLRPDSGGIELFGHDLVRRPELAARLLAYLGQESTALDDLTVALAAETTARLRGLPAAAARAERDAVLGELGLDRLADRPLRRLSGGERRLACVAAALVGERPLLVLDEPTTAMDPVARRAVWAAIDRRRAERGATVLLVTHNVIEAETVLDRVAVLDRGRVIACDSPAGLKALVGGEVRVDLVWRDEPPLDLPQIAELARTARRTGRRWTLRLPEDAARAAVAAVTGGPAFAALDDFTLTTPSLEDVYLALGGRDEGLVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N541</accession>
    <name>A0A0F7N541_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">D-alanyl-D-alanine carboxypeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_13780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S13 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_13780"/>
    <dbReference type="EnsemblBacteria" id="AKH83126">
        <property type="protein sequence ID" value="AKH83126"/>
        <property type="gene ID" value="AA958_13780"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_13780"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2902"/>
    <dbReference type="OrthoDB" id="720131at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000667">
        <property type="entry name" value="Peptidase_S13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30023">
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02113">
        <property type="entry name" value="Peptidase_S13"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00922">
        <property type="entry name" value="DADACBPTASE3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00666">
        <property type="entry name" value="PBP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="59"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH83126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="520" mass="53034" checksum="6483081D66D86F02" modified="2015-07-22" version="1">MRVRVAVARRKAARWVRHWTRRWEAQPLHTRRTVRLVAASGALGGVLAAGMIAAAGPWDSGQRTAEKQTAARADAAGGRTGDADHGSSDGVPGKGAPGDGLQGAGAGAPRVLTPLGPQDGTRPVAAPRPTGAGLAKELAPLLKDPALGSPTTAAVWDVTTGRELYGAHETTGVVPASTVKLATGAAALAALGPDHRIPTASLAEGGEVFLVGGGDPTLSAKRLKGLARDTARKLKKDGVRKVAVRYDATAYAGDVLHEIGPNENIAPVTPLMVNEARLDDSWHGPAPRGTDPARDAADAFAGELREAGVRVAGEPRAERVPEKAGELAATYSAPLAELTERMLTYSDNDLGEALARQTAIAAGRDASFAGSGKAVAGQLKKLGLPVRGARFADGSGISRDNRVSADLLARLLVTAADPDRPELRSLLTGLPVAGFNGTLRDRYGDAGADGSDAGDTAAARGVVRAKTGTLTGVNSLAGTVVDADGRLLAFAFFTMGATDRTGAGDALDRMAAAVASCGCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N563</accession>
    <name>A0A0F7N563_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_13890</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016474.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_13890"/>
    <dbReference type="EnsemblBacteria" id="AKH83146">
        <property type="protein sequence ID" value="AKH83146"/>
        <property type="gene ID" value="AA958_13890"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_13890"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2923"/>
    <dbReference type="OrthoDB" id="1834774at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
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            <end position="69"/>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
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            <end position="234"/>
        </location>
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            <begin position="255"/>
            <end position="282"/>
        </location>
    </feature>
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            <end position="325"/>
        </location>
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        </location>
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        <location>
            <begin position="448"/>
            <end position="466"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH83146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="491" mass="51106" checksum="2569C9E5A1A34499" modified="2015-07-22" version="1">MTSSPLGPPAAGTETETGTGTGTGPGPAAETVVPASPASAPAAGRRWDLLAAGLAAVAITTAALVGRAVNDRDILHVHFPPLSAVWEPHYGPGTPAALAVAAAVVAYGPALADRLPWRRLLLTTWAASMAWIWSLALVDGWRDGVTGQLTATNEYARPETVARFADLGHAVRTFTDHILIQTPDNWPAHIAGHPPAAILTFVGLDRAGLGGGAWAAVFCITVGGSAAVAVLVALRTLGGEERTRRAAPFLVLGPWAVWAGVSADGYFAAVAAWGLALLALAATRTARRPAGAATGAGLLLGWAVYLSYGLTLLVLPMAAVLWCAARRGRGTGVLRTLPWVVLGALPVAVAFTAAGFWWWEGYTLLHERYYQGFGGERPYSYWVWANLTVAAISAGLAAVAGTRRAVRTACRRGAGRSSAYAVAVMAVAGLACLVAADLSGLSKAETERIWLPFTLWLLPAAALLPARDHRTWLTAQAAVALAVNHLLVTSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N578</accession>
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        </submittedName>
    </protein>
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        <name evidence="4" type="ORF">AA958_13985</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
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    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
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        <property type="gene ID" value="AA958_13985"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_13985"/>
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    </dbReference>
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        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
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        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519796" evidence="2">
        <location>
            <begin position="43"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_4" evidence="3">
        <location>
            <begin position="122"/>
            <end position="365"/>
        </location>
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            <begin position="34"/>
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        </location>
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        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH83161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="414" mass="44293" checksum="DD1AF563BFF8B037" modified="2015-07-22" version="1">MSRTRRTTRPGARHRLAAPAAALLAAALLASCSSDAPKDDLADDPAASEQAEDGGKQSEFFDQADYDRQLELTKATPEGPEGKPWEQMLDPQSGGMVDTSEYAMKGGVEGAKLCFSNAGVFNPWRQVGLKTMKAEVAQHDEIADFTVLDAQGKDDKQISDIQELSGQNCDALIVSPNTTATLTPAVEEACGKIPVIVFDRGVETDCAITFISPIGGYAYGAAAADFLVDEVDKGGKIVALRISPGVDVLETRWSAAEIAFEKAGLDVVEVKFTDGDPSKAKSIVSDAIARHGQIDGVWMDSGATSVAAVEAFEDAGEDIPPITGEDQQDFLQAWKDKDLTAIAPAYPTFQWRTPVIAALKILAGEEVPKEWTLPQPVVTEENFDEYYKEGMPPLHYGACGCEDLPGYPGDWGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5M9</accession>
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        </submittedName>
    </protein>
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        <name evidence="6" type="ORF">AA958_11235</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomyces</taxon>
        </lineage>
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    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the stealth family.</text>
    </comment>
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    </dbReference>
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AKH82708">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0270">Exopolysaccharide synthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="398"/>
        </location>
    </feature>
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        <location>
            <begin position="411"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF11380"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF17102"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AKH82708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="525" mass="57120" checksum="CD08211E50FCE547" modified="2015-07-22" version="1">MGQTVMDQRPPRVGPGTASVVAAYRRALPRAVRRHLAVLTAPHHADRLRAALKARREQAASEAPGRVVLTVDGRPRIAQLQRALSPVQARRAGVLGVTRALRTAGVPYFAVRGRACGPSVVAVPADQRRRACRALARLCRVQPAYVTVVAGAGAGPGARSGAGHEARVRTGPARDGAAGAYPRLVPGYEPGVWQQLEKADVLRLTWYRTEPGLRLVIGGDSGCEVEFWHEDATGDRLLAPRPGRVADSVPAGATTVKMTDRGSWGCGRLTLRTREEFAHPLPEDVTYAVDAVFTWTDPELRYALRSLATYAPWLRHIHLLTDDGEPSWLDTAHPGLKVVAHREVFADPTMLPTSNPRAVESQLHHIEGLAEHFLYFGDRLFLGTETVPEQFFLANGLTRFFVSPVQEPLRHAPHPLRRSVLCEIEREFGDRHVATAAHREPRRDDLAIASSLYHHYAAHTGRAAAATLRHADVDLAAPGADTVLRGLLAARNRTVIRARGTGAPGQLGAFLEAYFPVPSAYELPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5Z1</accession>
    <name>A0A0F7N5Z1_9ACTN</name>
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        <submittedName>
            <fullName evidence="2">Methyltransferase type 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_08335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH82237">
        <property type="protein sequence ID" value="AKH82237"/>
        <property type="gene ID" value="AA958_08335"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_08335"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1759"/>
    <dbReference type="OrthoDB" id="1812981at2"/>
    <dbReference type="Proteomes" id="UP000034283">
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    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DinB_2" evidence="1">
        <location>
            <begin position="50"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="182" mass="20792" checksum="6392134A4B75AF97" modified="2015-07-22" version="1">MITPDTKDWTWVLDRPCPECGFVAAETRAQDVPALVRKSAVRWVQVLADEPERLRARPRPDVWSALEYACHVRDVFRLYDERLDLMLTQDGPTFANWDQDETAVAERYGEQDPLQVAAELSAWAETLAEHLDEVGEGRWQRTGFRSDGAAFTVDTFARYFVHDVIHHLYDVGALDRSAEGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N691</accession>
    <name>A0A0F7N691_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Virulence factor Mce family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_12465</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016248.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_12465"/>
    <dbReference type="EnsemblBacteria" id="AKH82913">
        <property type="protein sequence ID" value="AKH82913"/>
        <property type="gene ID" value="AA958_12465"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_12465"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2619"/>
    <dbReference type="OrthoDB" id="807474at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005693">
        <property type="entry name" value="Mce"/>
    </dbReference>
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        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024516">
        <property type="entry name" value="Mce_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11887">
        <property type="entry name" value="Mce4_CUP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00996">
        <property type="entry name" value="Mtu_fam_mce"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MlaD" evidence="2">
        <location>
            <begin position="53"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Mce4_CUP1" evidence="3">
        <location>
            <begin position="167"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="393"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="448"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH82913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="464" mass="47695" checksum="5C8F481241F70BEC" modified="2015-07-22" version="1">MNWHVKTVAGVVAAALVIASPLVVREVYESADVEFTGIQDLPLPGGADLGSHPYEVTAEFEDVLSLVPQSSVRVNDVAVGRVTDIEVADDRWTAVVTMKVNGDVRLPAGAYARIEQSSLLGEKYVQLLAPPGKKQADAEQAGDLGTAPGDVTTAILPDDGGTDIPLARTNRNPQVEEVFGALSMLLNGGGIEQLRTISRELNDALQGNEPQVRSMLKRVDTLMTSLDDNKDGITDALDSVNRLSATLATRKTEIGVILDDLSPGMKVLEEQRGALVTMLRSLDRLSDVAVETIDASKEDMIADLRALGKVLKNLADAGQALPASLEVLLTYPFTDEVLRGVKGDYLNIYLAVTAPSGTELIPPLTEDPVPGSGDPGGAPTGTALSLPLPSVGPTTPGAGPPASPDPGGPAPDGTGPRDPGSASPGGGPSDGAGIPSGSPPGSPSATEPESPPASGSESPGGESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6G9</accession>
    <name>A0A0F7N6G9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AA958_20880</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017525.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH84240">
        <property type="protein sequence ID" value="AKH84240"/>
        <property type="gene ID" value="AA958_20880"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_20880"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4401"/>
    <dbReference type="OrthoDB" id="1891092at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00164">
        <property type="entry name" value="ABC2TRNSPORT"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="65"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="111"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="149"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="236"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="9">
        <location>
            <begin position="13"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AKH84240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="266" mass="28384" checksum="8EA65972281EB169" modified="2015-07-22" version="1">MSTLALAVRDSATMLRRNLLHARRYPSMTLNLLLTPVMLLLLFVYVFGDTMSAGLAGGAPDRDVYIAYVVPGLLLMTIGSTTIGTAVSVATDMTEGIVARFRTMAIHRGSVLIGHVLGSVLQCLASVVFVGAIAVAIGFRSTDATVLEWLAAFGLLALFAMALTWVAVGMGLVSPNAEGASNNATPLILLPLLSSAFVPLDAMPGWFRPIAEYQPFTPAIETLRGLLLGTEIGHDGWLSFAWCLGLVVLGYLWSKASFNRDPKEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6V2</accession>
    <name>A0A0F7N6V2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_13645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016433.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_13645"/>
    <dbReference type="EnsemblBacteria" id="AKH83103">
        <property type="protein sequence ID" value="AKH83103"/>
        <property type="gene ID" value="AA958_13645"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_13645"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2872"/>
    <dbReference type="OrthoDB" id="1774182at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010814">
        <property type="entry name" value="DUF1416"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07210">
        <property type="entry name" value="DUF1416"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="95" mass="9604" checksum="E82DBD57BFAD36FC" modified="2015-07-22" version="1">MCGAKAGGPDAASVKAGETTIQGSVTRDGEPVTGYVRLLDASGEFTAEVPTSATGQFRFYAAEGTWTVRALVPGATADRTVVARQGGLSEVAIAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N717</accession>
    <name>A0A0F7N717_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_14150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016512.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH83184">
        <property type="protein sequence ID" value="AKH83184"/>
        <property type="gene ID" value="AA958_14150"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_14150"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2978"/>
    <dbReference type="OrthoDB" id="2094787at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="111" mass="12407" checksum="CB33D69F08103A75" modified="2015-07-22" version="1">MLDRIASVLDPLLRLLWPATGRRRYLPSLRAAAPVLFPYPVPAPPAPAAPPPDRHAPDRHAPATPRVRPYVLAHERRAEARRQRARRLELWLAVHGVDVGPRLIHGVEVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N742</accession>
    <name>A0A0F7N742_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_14330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016530.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_14330"/>
    <dbReference type="EnsemblBacteria" id="AKH83214">
        <property type="protein sequence ID" value="AKH83214"/>
        <property type="gene ID" value="AA958_14330"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_14330"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3016"/>
    <dbReference type="OrthoDB" id="1351747at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="19"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
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    </evidence>
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</entry>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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                <person name="Albersmeier A."/>
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                <person name="Kalinowski J."/>
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                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
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    </dbReference>
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            <dbReference type="EMBL" id="AKH83269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
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            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="86" mass="9301" checksum="95D6F2CBF6F3F5BF" modified="2015-07-22" version="1">MSDWTWHYNPDAELVTAGLPVEVVVEVERLAEQLTALGHDAAAAGRGPAHGGGLRTLDIFGGRGFFMYLAPERARVISIVRVVWVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7E1</accession>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">CNQ-509</strain>
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    </dbReference>
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            <end position="132"/>
        </location>
    </feature>
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    </evidence>
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            <dbReference type="EMBL" id="AKH83941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="132" mass="13886" checksum="FA13192ACD141B9F" modified="2015-07-22" version="1">MAGLTAAGIAGRIEDLYGEPLADLKAHPEAQRPGMLAALLGMHQALADAEHSITFHRDYLTRLLQPGRQLGPHEISHLLDGTRRLAEAVAVHDVQAASAAAVLQSLTRPAASPPTTEPPSPPPRSTAAARSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7E2</accession>
    <name>A0A0F7N7E2_9ACTN</name>
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        </submittedName>
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    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Albersmeier A."/>
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                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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        </subcellularLocation>
    </comment>
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    <dbReference type="STRING" id="444103.AA958_11580"/>
    <dbReference type="EnsemblBacteria" id="AKH82767">
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
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            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
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            <begin position="100"/>
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        </location>
    </feature>
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            <end position="153"/>
        </location>
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            <end position="185"/>
        </location>
    </feature>
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            <end position="225"/>
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            <end position="268"/>
        </location>
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            <end position="320"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="341"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="370"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="399"/>
            <end position="419"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="425"/>
            <end position="447"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="453" mass="47266" checksum="74170BDABF271F7C" modified="2015-07-22" version="1">MSKSSTEAAGPTPTDSGTPLKRAIGPKLLLLFVVGDILGTGIYANTGAVAGRIGGALWVPFVIGFVVAMLTAASYVELVGKYPRAAGAALYTQKAFRVPFLTFIVAFMVMCSGLSSASAAARAFSGDYLQEFVDISPTLIAILFVLLLASLNLRGVSESVKTNVVLTVVEVTGLLVILGIGVAAVLTGEGEPSRLTEFETGGTGYAVLTGVLGATALGFFAFVGFEDSVNMAEETKDPVRNFPRAIFLGVAITGTIYVLVALVSSLMVDHERLAGSSGPLLLVVDESGVDFPAKLFALIALFAVSNSALINIMMASRLCYGLANERVLPRAMARVLPGRRTPVVGIVFVTALAIGLVSTGEIEGLGDTTSFLLLCVFAVVNVAVLVLRRDPVDHRHFRAPTWIPVLGAVTAGILASPLSDRPADVYIRAGVLLAIGIGLWIVNQVAVRAAGQR</sequence>
</entry>
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    <accession>A0A0F7N7F9</accession>
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    <reference evidence="2 3" key="1">
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                <person name="Leipoldt F."/>
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                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
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    <dbReference type="EnsemblBacteria" id="AKH83333">
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        <property type="gene ID" value="AA958_15160"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="1242748at2"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0004115">
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="4"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="252" mass="27102" checksum="BD6ED2B3035BC05C" modified="2015-07-22" version="1">MAVIAHFSDVHIDDERSVLRTRAVVEYLEELPYDLDLVLVTGDIADHGAPAEYATARELLASRHPVLVCPGNHDDRAAFRSGLLGEAAASGPVDQVHRGDGFTVLACDSSVPGKPEGWLGDETLAWLEGELGRVPEGEPVLVAFHHPPVELHVPYVDEIRQFDAARLAELAGRHGQVAAFLAGHAHTAAATTFAGRPLLVAPGVVNTVRLPWERQGDAAHHVHLDQPPALAFHVLEADGRLTTHFRTVSTEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7U6</accession>
    <name>A0A0F7N7U6_9ACTN</name>
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    <organism evidence="2 3">
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH82867">
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    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_12175"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2561"/>
    <dbReference type="Proteomes" id="UP000034283">
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="68" mass="7709" checksum="B627EC8EE5522A2A" modified="2015-07-22" version="1">MGAFDKAKDMASEAAEKAKQAAQKAQQSREQKQESGQDPSQRAKEGAEQGRDRMKGDRDERDDKREQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7X2</accession>
    <name>A0A0F7N7X2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sortase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_16290</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016815.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_16290"/>
    <dbReference type="EnsemblBacteria" id="AKH83509">
        <property type="protein sequence ID" value="AKH83509"/>
        <property type="gene ID" value="AA958_16290"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_16290"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3432"/>
    <dbReference type="OrthoDB" id="1022681at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05830">
        <property type="entry name" value="Sortase_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005754">
        <property type="entry name" value="Sortase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023365">
        <property type="entry name" value="Sortase_dom-sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042003">
        <property type="entry name" value="Sortase_E"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04203">
        <property type="entry name" value="Sortase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63817">
        <property type="entry name" value="SSF63817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01076">
        <property type="entry name" value="sortase_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="63"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="21"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH83509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="287" mass="31807" checksum="AFFA88D0C1B46598" modified="2015-07-22" version="1">MAATDDERESRPAAEAAGEAAPKAREPEDAGEEAAGPVRDDGETAAEEEAGEAAPPRPRRRGLLAGAVSLFGEVLITVGVLMALFVVYSLYWTNVQANREAGRMTDDLRDSWENTPDDGKPRPVDIGDLKGGIGFLHVPAMEENILVRKGTATDDLNKGVAGYYTEPKKSAMPWDRRGNFTLAAHRDGHGAKFHDIHRIEEGDPIVFETKDRWYVYKTYAVLSETSKYNTAVLDKTPEESGKTKPGRYITLTTCTPMYTSRHRYVVWGELERVDRVDEERTPPPELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7Y4</accession>
    <name>A0A0F7N7Y4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Bacterial proteasome activator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_16500</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Forms a homooligomeric, either hexameric or heptameric, ring-like structure which stacks co-axially with the proteasomal alpha-rings.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Bpa family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016848.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_16500"/>
    <dbReference type="EnsemblBacteria" id="AKH83543">
        <property type="protein sequence ID" value="AKH83543"/>
        <property type="gene ID" value="AA958_16500"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_16500"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3472"/>
    <dbReference type="OrthoDB" id="1767315at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061136">
        <property type="term" value="P:regulation of proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019695">
        <property type="entry name" value="Proteasome_act"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10759">
        <property type="entry name" value="DUF2587"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="161"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH83543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="188" mass="20223" checksum="B4FB472F83148284" modified="2015-07-22" version="1">MNTPSNERPPETPQVVVVGPDGMARGTVAPGDGGADEEGREIPLTDKVEQPAKVMRIGSMIKQLLEEVRAAPLDEASRARLKEIHSSSVKELEDGLAPDLIDELERLTLPFTDETVPTEAELRIAQAQLVGWLEGLFHGIQTTLFAQQMAARAQLEQMRRALPPGGGLGGDDQGEMGPEHGRTGGPYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N804</accession>
    <name>A0A0F7N804_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutamate-1-semialdehyde 2,1-aminomutase</fullName>
            <shortName evidence="7">GSA</shortName>
            <ecNumber evidence="7">5.4.3.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Glutamate-1-semialdehyde aminotransferase</fullName>
            <shortName evidence="7">GSA-AT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">hemL</name>
        <name evidence="10" type="ORF">AA958_20370</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(S)-4-amino-5-oxopentanoate = 5-aminolevulinate</text>
            <dbReference type="Rhea" id="RHEA:14265"/>
            <dbReference type="ChEBI" id="CHEBI:57501"/>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <dbReference type="EC" id="5.4.3.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from L-glutamyl-tRNA(Glu): step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.4.3.8" evidence="7"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017440.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_20370"/>
    <dbReference type="EnsemblBacteria" id="AKH84151">
        <property type="protein sequence ID" value="AKH84151"/>
        <property type="gene ID" value="AA958_20370"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_20370"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4290"/>
    <dbReference type="OrthoDB" id="493793at2"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00317"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042286">
        <property type="term" value="F:glutamate-1-semialdehyde 2,1-aminomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00375">
        <property type="entry name" value="HemL_aminotrans_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004639">
        <property type="entry name" value="4pyrrol_synth_GluAld_NH2Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00713">
        <property type="entry name" value="hemL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 7" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="4 7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="437"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AKH84151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="456" mass="47019" checksum="7282917CA5241704" modified="2015-07-22" version="1">MACVTYPYQAPVSQKLYDRAAAVTPGGVNSPVRAFRAVGGTPRFMVSGKGPYLTDADGREYVDLVCSWGPMILGHAHPEVTAAVQEAVARGTSFGTPGAGEVALAEEIVSRVTPAEQVRLVSSGTEATMSAIRLARGFTGRAKVVKFAGCYHGHVDALLAAAGSGVATLGLPDTPGVTGAQAGETLVLPYNDLAAVRAAFEEHPGDIACVITEASPGNMGTVPPLPGFNQGLKDLCTEHGALYVSDEVMTGFRTSRAGWYGVDGVTPDLMTFGKVMGGGFPAAAFGGRADVMARLAPAGPVYQAGTLSGNPVATAAGLAQLRLLDDAAYDTLDAVSRQLRGLVTEALAKEGVPHRVQTASSMFSVFFTGSDSPVIDYEGAKAQRREQFTAFFHAMLAEGVYLPPSAFECWFVSTALDGDAMERIARALPVAARAAAEAGDEAGGGSPAGGRDVQNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-12-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N807</accession>
    <name>A0A0F7N807_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_23760</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017977.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH84725">
        <property type="protein sequence ID" value="AKH84725"/>
        <property type="gene ID" value="AA958_23760"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_23760"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5007"/>
    <dbReference type="OrthoDB" id="1697277at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005344">
        <property type="term" value="F:oxygen carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001486">
        <property type="entry name" value="Hemoglobin_trunc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01152">
        <property type="entry name" value="Bac_globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="SSF46458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0561">Oxygen transport</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH84725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="155" mass="17532" checksum="0DA5BC3E0CC884EA" modified="2015-07-22" version="1">MSEDTPSIYEWAGGDEAFLRLTATFYGHVRKDPVLAPVFAGMDGEHPRHVAMFLAEVFGGPERYSAERGGHDHMARMHLGRHITEEQRRRWVSLLMDSADEVGLPTDPEFRAVFSYYIEWGTRMALVYSADDPPPTAGPMPKWEWGQTPPWQPGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N835</accession>
    <name>A0A0F7N835_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Fe-S oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_23920</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018002.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_23920"/>
    <dbReference type="EnsemblBacteria" id="AKH84750">
        <property type="protein sequence ID" value="AKH84750"/>
        <property type="gene ID" value="AA958_23920"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_23920"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5041"/>
    <dbReference type="OrthoDB" id="1172757at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026335">
        <property type="entry name" value="SAM_SPASM_FxsB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023867">
        <property type="entry name" value="Sulphatase_maturase_rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43273">
        <property type="entry name" value="PTHR43273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04269">
        <property type="entry name" value="SAM_SPASM_FxsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="6">
        <location>
            <begin position="42"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH84750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="414" mass="44102" checksum="B69E64307DFBFDA1" modified="2015-07-22" version="1">MDYGGTGAEEEAPWPGRLLDVDRLRAAGVRAVPFRQFILKVHSRCNLSCTYCYVYHGADSGWRGRPALMPEAVTRRTAQRIAQHVRAHGLRRIHLVLHGGEPLLAGAASLVRQTTVVRAALPAGCAVVAGVQTNGTLLTESALETLAAGGIRVGLSADGGTSELNSRRVDHAGRPAWPALERAARLLRRHPESYGGILCTVDVTASPGAVLDSLCALDPPVIDFLLPHANWSAPPAPVPGRGPTPYGDWLCEVFDLWWNLPRPSPRVRMFTEILGLLLGRPSGTESVGLSPVTALVVETDGAIEQIDSLKSVYEDAAGTGLDVFRNSFDEALNHPGIAARQLGLRALSAQCRSCAVVGVCGGGNYAHRFRAGEGFRNPSVYCADLERLIRHVAHRLAAAVAGQRKVTAGPPCVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N870</accession>
    <name>A0A0F7N870_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_23970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018012.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH84760">
        <property type="protein sequence ID" value="AKH84760"/>
        <property type="gene ID" value="AA958_23970"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_23970"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5052"/>
    <dbReference type="OrthoDB" id="2205045at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="90" mass="9745" checksum="7A88BDCA447F386F" modified="2015-07-22" version="1">MTISSEELAEVRIALRRTLPRDASRPPEPESGAVGGEEASDLLGRLMTLGATLVEGRELAVTELADRLTRSEMRTCITDQALGRAFVFGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N871</accession>
    <name>A0A0F7N871_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AA958_17165</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M48 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016957.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_17165"/>
    <dbReference type="EnsemblBacteria" id="AKH83653">
        <property type="protein sequence ID" value="AKH83653"/>
        <property type="gene ID" value="AA958_17165"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_17165"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3609"/>
    <dbReference type="OrthoDB" id="1707650at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="289"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M48" evidence="8">
        <location>
            <begin position="124"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH83653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="311" mass="32422" checksum="D938948E96E5EC72" modified="2015-07-22" version="1">MSEALPVLGYAAVLGVVAPRFVLRGAWPHRAPRLAVAVWHALAVAFTLSVALAAYHLATPTEHLHASFVGFLHSCGLGLDRGVDLGLGTGRPDPGVASRLAGVLPAAVAGAVAVSVGGHALRARRVRARHRAVLDMVGRRSSALGATVVAHGTPVAYCLPGRRARVVVSEGALRLLSAAQVDAVLEHERAHVAGRHHLPQAAADGFAAVFRGLPLARHVRRQTALLLEMAADDRALRRHPGRVLATAMYEMAACRAPRGAFAVGGGTVPVRLRRVLGPRRRAHPVLRGAVAAVALTVPLVPLLVACPPALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N894</accession>
    <name>A0A0F7N894_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Molybdate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_17110</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial solute-binding protein ModA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016948.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_17110"/>
    <dbReference type="EnsemblBacteria" id="AKH83644">
        <property type="protein sequence ID" value="AKH83644"/>
        <property type="gene ID" value="AA958_17110"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_17110"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3598"/>
    <dbReference type="OrthoDB" id="1506401at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015689">
        <property type="term" value="P:molybdate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005950">
        <property type="entry name" value="ModA"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004846">
        <property type="entry name" value="ModA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01256">
        <property type="entry name" value="modA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519302" evidence="4">
        <location>
            <begin position="40"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>molybdate</name>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>molybdate</name>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>molybdate</name>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>molybdate</name>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR004846-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH83644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="275" mass="27620" checksum="C213743E907CD45D" modified="2015-07-22" version="1">MTRSARRTGGCRPTLRMAGAGAAALLALTACSDSDPAPGSDPGKGGESGELSGEVTVFAAASLTESFEKLGAQFEKDHPGTNVTFSFGGSDALAASITGGAPADVFASASPTTMEIVADAGAAAGTPETFVRNRLEIATLPGNPDGIASLKDLTDPGLKVVICDETVPCGSAVRKALDAGALKLTPVSYEEDVKSALTKVMLKEADAAVVYKTDVRAAGGTVEGVDFPESAGAINDYPITLLEEAPNAAAAEAFVGLVQSAAGQKVLTEAGFLKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-10-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8B0</accession>
    <name>A0A0F7N8B0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_21115</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH84276">
        <property type="protein sequence ID" value="AKH84276"/>
        <property type="gene ID" value="AA958_21115"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_21115"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4446"/>
    <dbReference type="OrthoDB" id="1932479at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH84276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="205" mass="21664" checksum="311ED87480C95BFA" modified="2015-07-22" version="1">MALVTFEVPAGYSQMPVGLTLAQTGEFVAGPAAVTEIAGDEAENQTVQLQQWSTALQALGAMYAGAYWPGEGDLSRFGVLLVAAQPLTYGDAHLASRGLPHALRGPEDDAIAAKPFDLPCGPASVFARQIGLPAEGERSAAEGGAVVPVGELQAFVPVPRELSAGREEMVVVAVQTPDLDHWDMYAQHLVLLLKSIQFDEEPRSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8D4</accession>
    <name>A0A0F7N8D4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Universal stress protein UspA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_17425</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016998.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH83694">
        <property type="protein sequence ID" value="AKH83694"/>
        <property type="gene ID" value="AA958_17425"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_17425"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3665"/>
    <dbReference type="OrthoDB" id="2040681at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="7"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="164"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH83694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="292" mass="31503" checksum="E7E53274FE90EF3D" modified="2015-07-22" version="1">MAGASGRRPIVAGVDPDPAKRLALLWAADEAGRRHLPLRLVHAQALPPLPGGHRSEAVRRYREEWSRALRGVGDELLRQAAEFAESRQPSVEVSTVLAEEEPASVLLQEARNASLVVVGSRHLSRRREMFTPDSVALPLTARAPCPVIVVREPEHVTQEPAYFVVGVDGSAHSAAAVDMAFEEAGLRGAQLRALYVWHPPLLGPADEHATMRECRRVLSETVAGREAAHPDVELHHEVLRGHPVQVLTDASEHSLGLVVGTRGRGGFAGMLLGSVSQGVLRHARCPVISVPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8F3</accession>
    <name>A0A0F7N8F3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_17885</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017070.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_17885"/>
    <dbReference type="EnsemblBacteria" id="AKH83768">
        <property type="protein sequence ID" value="AKH83768"/>
        <property type="gene ID" value="AA958_17885"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_17885"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3767"/>
    <dbReference type="OrthoDB" id="1791088at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH83768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="167" mass="18386" checksum="410E3744FC553681" modified="2015-07-22" version="1">MSDNQQSESHDGAPLPETLRFFGTTWVDRSRGYWARRVGVAVLALVLAAAGAFVLALSYNGLQLADSGGIIQLLMIAAFAVCSSLAFTRTLGGFSRPHEAGPADSSWRPIRVIGFVGVLLAYTVRSFAEAPGEGMLRKDYEHRLEQHARRRSSRTGNPAKRKRKKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8J2</accession>
    <name>A0A0F7N8J2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AA958_24540</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018102.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_24540"/>
    <dbReference type="EnsemblBacteria" id="AKH84850">
        <property type="protein sequence ID" value="AKH84850"/>
        <property type="gene ID" value="AA958_24540"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_24540"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5170"/>
    <dbReference type="OrthoDB" id="345602at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="384"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="424"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="470"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="500"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="532"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="611"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="11"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="254"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="315"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="44"/>
            <end position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AKH84850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="644" mass="65673" checksum="65505512A3D6576B" modified="2015-07-22" version="1">MSVPPAAGLRLRARRVSRDVRGAGRVLRGVSLDVAPGTLTVIAGSSGAGKTVLLQTLAGLSVPSEGDVWHDGAPPGPPGPEFGYVPQEDIIHRELPLHRTLVYAAGLRMPPRTPAAAVAATVDRVLATLGLTSRRDTPVRALSGGERKRASIAVELLTRPRVLFLDEPTSGLDPATGAELMHTLRGLADDGTTVVLTTHVLADLPRGDQVVFLSADGEVAYAGEPGALCETFGVHTAEEVYGAVAAGARAPGAGAGGLPERGDTWGPGAPSGPAARAGHAAPTGHAAPTGHAAPPGAVAPAGAVAATGLATATATAAEPSARSGPAATAGPATPADPTTPAAPAVPARAPSSAVPATTPARVGALRQWALLTRRGTALLLHNRLSVAVLVGSPVVIVAMFAVLFRGGAFDPASPDPGSTAMIMFWIAFGAFFFGLTYGLLQICTELAVLRREWLAGLRVGPYVASKLTTMLPALALADALLLAVLRALDRLPPAGWDTYASLLASSLLASAAALALGLLASAAVAEPGQATLMLPLLCFPQVLFSGAFVPVPRMTPGGEAISLAMTNRWAFEALGSGVGLESLWRTGVSPAGWPLLASYGESFGHPAARGWLILAGFAVLFLALTWWVVVRKCRDGAERSRQGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8S7</accession>
    <name>A0A0F7N8S7_9ACTN</name>
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        <submittedName>
            <fullName evidence="2">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">AA958_13870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83142.1"/>
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        <property type="gene ID" value="AA958_13870"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_13870"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2920"/>
    <dbReference type="OrthoDB" id="1445278at2"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
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    </dbReference>
    <dbReference type="InterPro" id="IPR018641">
        <property type="entry name" value="Trfase_1_rSAM/selenodom_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36529">
        <property type="entry name" value="PTHR36529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09837">
        <property type="entry name" value="DUF2064"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
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        <location>
            <begin position="222"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="247" mass="24976" checksum="DE437277F1924C57" modified="2015-07-22" version="1">MRGGGVTVLVIAKEPRPGRVKTRLTPAYTPAEAARLAEAALADTLAVVRGLPARRRVLVLDGAPGDWLPPGFTVVPQAAGGLDERLAAAFGGCTGPALLVGMDTPQLTAALLAPALAGDAWSACDAYLGPAQDGGFWALGLARPDPELLRGVPMSTPHTGAAQHRRLREAGLHVRELPPLRDVDTPADVPPVAEAAAPGSRFAATAHRLDAWTRAARAATAPGAAAPDGAAVHPAAADGAALDRAAG</sequence>
</entry>
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    <accession>A0A0F7N8Y3</accession>
    <name>A0A0F7N8Y3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_25395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018246.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH84995">
        <property type="protein sequence ID" value="AKH84995"/>
        <property type="gene ID" value="AA958_25395"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_25395"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5353"/>
    <dbReference type="Proteomes" id="UP000034283">
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="194" mass="18870" checksum="424BD4ADF0A2DF17" modified="2015-07-22" version="1">MAGLAATVVPAVAGGALVLGMAGPAAGDGAGGGHPGGRTAASAPALTDVDPSTLHLLGELGQLTAATARTVEQVRQAVADGGRQNPRTLPDVRAHLDAVGAAAGTKGTVKSMKARETTALAQAVGSLREELARLVRAGRAGDRAAVAERSPVTVTALVRVLSATAASGLVPAGQVPQTPPNAAVPPKLPARSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N907</accession>
    <name>A0A0F7N907_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_14410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016543.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_14410"/>
    <dbReference type="EnsemblBacteria" id="AKH83227">
        <property type="protein sequence ID" value="AKH83227"/>
        <property type="gene ID" value="AA958_14410"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_14410"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3032"/>
    <dbReference type="OrthoDB" id="1439833at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="40"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="308" mass="34551" checksum="B06DCEDF58CBD202" modified="2015-07-22" version="1">MTAPSPVDPAVHLEGPWTHRDVAANGARFHIVEMGEGPLVLLLHGFPQFWWTWRHQLPALAEAGYRAVAMDLRGVGGSDRTPRGYDPANLALDVTGVIRSLGEPDAALVGHDLGGYLAWTAAVMRPKLIRRLTVASMPHPRRWRSAMLTDPRQSAAGSFVWSAQRPWLPERQLVADDAALVGRLIRGWSGPRQPDDKALEVYRRAMTVPSTAHCSVEPYRWLVRSLGRPDGIQFYRRMKLPVRVPVLHLHGSLDPVMRTRSAAGSVAYVEAPYRWRLFDGLGHFPHEEDPLAFTTELVNWLRDPEPDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N957</accession>
    <name>A0A0F7N957_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_22810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017818.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_22810"/>
    <dbReference type="EnsemblBacteria" id="AKH84561">
        <property type="protein sequence ID" value="AKH84561"/>
        <property type="gene ID" value="AA958_22810"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_22810"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4802"/>
    <dbReference type="OrthoDB" id="764010at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013493">
        <property type="entry name" value="CHP02677"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09660">
        <property type="entry name" value="DUF2397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02677">
        <property type="entry name" value="TIGR02677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="385"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="532" mass="58391" checksum="DAFFDF184B326A23" modified="2015-07-22" version="1">MSAPESARHEAGRGPFAHLTVPHAARYRQVMAVFTAAKERFAVHLRPEDVHAALPPEERPAEVEAVAKALDSLVQWGNLRADPDTSRVTAVEDFYRKRFIYQLTPAGEAVELAIAAYDEALGRRGALQAVALHDIVTQLRALLVLAADDEPDAAKAHLALAALADRFAALAENARAFMGSLQRTIDLHGVEVEVFLAYKDRLIQYLERFIQDLIALGGRIARLIGELEQQGRVETLLRLAAARESADAAPEETETAQARAYERWAARWSGLASWFVSADGRESQARLLRGRALGAIPQLLAVVRQLNERRAGRTDRSADFRTLARWFAEAPDDAARHRLWRAAFGLYPARHLTIDADTLAARAAEPVPPATPWAAAEPLRISPQLRRTGSYERRGKPRRVRDRSAERRRLAEYAGRQAAEVAAARARLATGGEVRLSQVGELDPLAFGLFLRLLGDALATWRPDTLTTTVTSTDGTMEIRLTALRDGGRAEVRTPAGVFRGPDHLVEIITRAGTVQAVDMSADMPVDTGVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N960</accession>
    <name>A0A0F7N960_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_14775</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016592.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_14775"/>
    <dbReference type="EnsemblBacteria" id="AKH83277">
        <property type="protein sequence ID" value="AKH83277"/>
        <property type="gene ID" value="AA958_14775"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_14775"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3113"/>
    <dbReference type="OrthoDB" id="1670369at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH83277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="141" mass="15720" checksum="0AE21CAA98816C00" modified="2015-07-22" version="1">MRKQAGERGQRPLRVFVLDCEALSLAVRGDRKMIAWLDLAAGGEAEVVTSPMTLVEAYDGRTTEQRWDWVLSRIKAADIGKDEARQARRLLADVKLHGHKYAIDAVLAVIARQQKGQVTVFTSDVDDLEKLVPEPVVVKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9V8</accession>
    <name>A0A0F7N9V8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_27340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018565.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_27340"/>
    <dbReference type="EnsemblBacteria" id="AKH85330">
        <property type="protein sequence ID" value="AKH85330"/>
        <property type="gene ID" value="AA958_27340"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_27340"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5761"/>
    <dbReference type="OrthoDB" id="1986389at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013434">
        <property type="entry name" value="CHP02611"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019099">
        <property type="entry name" value="Uncharacterised_PGPGW_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09656">
        <property type="entry name" value="PGPGW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02611">
        <property type="entry name" value="TIGR02611"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="70"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH85330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="145" mass="16137" checksum="5C51C7C70B3278DF" modified="2015-07-22" version="1">MDKTDTDAPVAKLDEPEKPDAPEHSTWGSKAPHFIQRSRALHLSWQVGVFIVGLAIVIGGIILLPLPGPGWLVIFAGMAVWATEFVWAQIILHWTKRKVTEAAQRALDPKVRRRNAILTAIGLVICGVLLGVYLYEFGFEMPWKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NA56</accession>
    <name>A0A0F7NA56_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_25010</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the transposase 35 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018177.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_25010"/>
    <dbReference type="EnsemblBacteria" id="AKH84926">
        <property type="protein sequence ID" value="AKH84926"/>
        <property type="gene ID" value="AA958_25010"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_25010"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5271"/>
    <dbReference type="OrthoDB" id="222391at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001959">
        <property type="entry name" value="Transposase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010095">
        <property type="entry name" value="Transposase_IS605_OrfB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01385">
        <property type="entry name" value="OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07282">
        <property type="entry name" value="OrfB_Zn_ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="OrfB_IS605" evidence="6">
        <location>
            <begin position="187"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="OrfB_Zn_ribbon" evidence="7">
        <location>
            <begin position="314"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="239"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="255"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH84926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="401" mass="44282" checksum="F9FA30F8D1C2484B" modified="2015-07-22" version="1">MATSWQQRDGAGYARYTYRLRVSSSARAALTGEWARCRWVWNECVARSRKAHAEGDKCGPARLDKMLTEARSTMEWLSAGSSVPQQQTIRDFGKSRAKALKDIKAGIPVRRRSGMPRIKRKRDALPSLNYTRRGFRLKDGRLHLAGNIVLTVVWSRELPAEPSSVRVYRNAVGHWHCSFVVPAAVVPLPATGAVIGIDWGVKQIATTTSDDYDLPHPGHGKNAAHRLARYQRMMARRRPGRGRAASNGYRQAQRQAAKLHEKVARQRQDTARKWAKKVVADHDAIAVEDFRPRFLAKSTMARKAADAAVGAAKKALIEMGRKYGRDVRLVHPAHTTMDCASCGARTKHALPLSERTYTCTTCGALCPRDKNSARVMLLRAGLNPAGADGVRPTGAPPLEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAB3</accession>
    <name>A0A0F7NAB3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Serine hydroxymethyltransferase</fullName>
            <shortName evidence="7">SHMT</shortName>
            <shortName evidence="7">Serine methylase</shortName>
            <ecNumber evidence="7">2.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">glyA</name>
        <name evidence="10" type="ORF">AA958_25375</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine</text>
            <dbReference type="Rhea" id="RHEA:15481"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Amino-acid biosynthesis; glycine biosynthesis; glycine from L-serine: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the SHMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.1" evidence="7"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018242.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_25375"/>
    <dbReference type="EnsemblBacteria" id="AKH84991">
        <property type="protein sequence ID" value="AKH84991"/>
        <property type="gene ID" value="AA958_25375"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_25375"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5349"/>
    <dbReference type="OrthoDB" id="861782at2"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="UniPathway" id="UPA00288">
        <property type="reaction ID" value="UER01023"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="F:methyltransferase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:pyridoxal phosphate binding"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00378">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
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        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
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        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001085">
        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019798">
        <property type="entry name" value="Ser_HO-MeTrfase_PLP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="PTHR11680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000412">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00096">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4 7" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="6 7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SHMT" evidence="9">
        <location>
            <begin position="8"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="125"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
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        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
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        </ligand>
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        <location>
            <position position="57"/>
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        <ligand>
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        </ligand>
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        <location>
            <position position="64"/>
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        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="366"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7 8">
        <location>
            <position position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006376"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
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        <source>
            <dbReference type="HAMAP-Rule" id="MF_00051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000412-50"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AKH84991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="427" mass="45563" checksum="8624E5D4CBFEEFBC" modified="2015-07-22" version="1">MSLLNGSLHEVDPEVAAAVDAELKRQQSTLEMIASENFAPVAVLEAQGSVLTNKYAEGYPGRRYYGGCEYVDVAEELARERVKALFGAEAANVQPHSGASANAAAMFAVLKPGDTILGLDLAHGGHLTHGMKINFSGKLYDVAAYHVDAETGQVDMAEVERLAKERRPKLIIAGWSAYPRQLDFAGFRRIADEVDALLMVDMAHFAGLVAAGLHPNPVPYADIVTTTTHKTLGGPRGGVILSRQALAKKINSAVFPGQQGGPLEHVIAAKAVSFKIAASEEFRERQRRTLDGARILAERLLRDDARAAGVSVLSGGTDVHLVLVDLRASELDGQQAEDRLHEIGITVNRNAVPDDPRPPMVTSGLRIGSPALATRGFTAADFEEVADVIAEALKAPLTRWGSDDPKTAALAARVTALAQKHPLYPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAJ7</accession>
    <name>A0A0F7NAJ7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 13 15">tRNA (guanine-N(1)-)-methyltransferase</fullName>
            <ecNumber evidence="6 13 15">2.1.1.228</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">M1G-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">tRNA [GM37] methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">trmD</name>
        <name evidence="17" type="ORF">AA958_25935</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 13 15">Specifically methylates guanosine-37 in various tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13 15">
            <text>guanosine(37) in tRNA + S-adenosyl-L-methionine = H(+) + N(1)-methylguanosine(37) in tRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:36899"/>
            <dbReference type="Rhea" id="RHEA-COMP:10145"/>
            <dbReference type="Rhea" id="RHEA-COMP:10147"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="EC" id="2.1.1.228"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5 13 15">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 13 15">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13 15">Belongs to the RNA methyltransferase TrmD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.228" evidence="6 13 15"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018332.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_25935"/>
    <dbReference type="EnsemblBacteria" id="AKH85091">
        <property type="protein sequence ID" value="AKH85091"/>
        <property type="gene ID" value="AA958_25935"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_25935"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5461"/>
    <dbReference type="OrthoDB" id="525632at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052906">
        <property type="term" value="F:tRNA (guanine(37)-N(1))-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18080">
        <property type="entry name" value="TrmD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1270.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00605">
        <property type="entry name" value="TrmD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002649">
        <property type="entry name" value="tRNA_m1G_MeTrfase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023148">
        <property type="entry name" value="tRNA_m1G_MeTrfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016009">
        <property type="entry name" value="tRNA_MeTrfase_TRMD/TRM10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46417">
        <property type="entry name" value="PTHR46417"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01746">
        <property type="entry name" value="tRNA_m1G_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000386">
        <property type="entry name" value="tRNA_mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00088">
        <property type="entry name" value="trmD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 13 15" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 13 14" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="10 13 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="12 13 15" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA_m1G_MT" evidence="16">
        <location>
            <begin position="22"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="13 14">
        <location>
            <begin position="136"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00014679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000386-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AKH85091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="269" mass="29373" checksum="79A9E1648B35D073" modified="2015-07-22" version="1">MRIDVVSIFPAYLEPLRLSLPGKAIERGVLDVRVHDLREWAFDRHHTVDDTPYGGGPGMVMKPEPWGAALDAVAGSGTGDPVLVVPTPSGRPFTQELAVELAAEPWLVFAPARYEGIDRRLVEEYAGRYRLHEVSIGDYVLAGGEAPVLVIAEAVVRLLPGVLGNAASHQDDSFAPGAMADLLEGPVYTKPPDWRGRTVPDVLLSGDHGRIARWRRDQALRRTAEVRPDLIARAAPGAYDKHDRALLAELGWAEGPDGRFWRTGADVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBA9</accession>
    <name>A0A0F7NBA9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_30275</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019023.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_30275"/>
    <dbReference type="EnsemblBacteria" id="AKH85795">
        <property type="protein sequence ID" value="AKH85795"/>
        <property type="gene ID" value="AA958_30275"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_30275"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6396"/>
    <dbReference type="OrthoDB" id="1427617at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH85795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="315" mass="34871" checksum="1FD17AA7F6D98CEA" modified="2015-07-22" version="1">MTTREVEHTIDIGAPADTIYTLLADVGHWPRIFPPTIYADREETGPDEERIRIWATANGAAKNWTSRRFLYPAERRIRFRQEVSTPPVAEMGGTWIIEELGAGGSRVRLLHDYRAIGDDPDDLAWIDRAVDTNSTSELASLKENVERAHAADRSELTFSFSDEVRIEGSAKDVFDFINEAGQWPERLPHVATVRFSEETPGLQSLEMDTRAKDGSTHTTKSYRVAFAPHRIAYKQVTLPALMTLHTGIWTFEEDGGGGAVTATSQHTVTINTENIARILGEQATVADARAYVQGALSANSSATLGHAKDYAERMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBH4</accession>
    <name>A0A0F7NBH4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_28205</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018710.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_28205"/>
    <dbReference type="EnsemblBacteria" id="AKH85476">
        <property type="protein sequence ID" value="AKH85476"/>
        <property type="gene ID" value="AA958_28205"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_28205"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5945"/>
    <dbReference type="OrthoDB" id="1338921at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021235">
        <property type="entry name" value="DUF2637"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10935">
        <property type="entry name" value="DUF2637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="58"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="125"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH85476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="346" mass="37382" checksum="152CA6F6DD9CB410" modified="2015-07-22" version="1">MGFNGIPLSWALPAAVLLLGVLAAIAVVVRGRQKADEPADSWEAGEQRRRRKEAMYGTLAYVLLFCCAAVAAALSFHGLVGFGRQNLGLSGGWEYLVPFGLDGAAMFCSVIAVREASNGDAALGSRLLVWTFAGAAAWFNWVHAPRGTGHAGAPQFFAGMSLSAAVLFDRALKQTRRAALREQGLVPRPLPQIRFVRWLRAPRETFRAWSLMLLEGVRTLDEAVDEVRQDSRDEARRRAEEREQARLERARLKALGKHQRALAPGDFTAARAEPQVALTPEPVTEAARFPLRSRSAPETRPAVAGGPSGGQPPAKSVAAAAGPDDALAAPLDTLEQKLTAMENQYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBR3</accession>
    <name>A0A0F7NBR3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Clp protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_31075</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019148.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH85920">
        <property type="protein sequence ID" value="AKH85920"/>
        <property type="gene ID" value="AA958_31075"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_31075"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6567"/>
    <dbReference type="OrthoDB" id="1959218at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
        <property type="entry name" value="SSF81923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51903">
        <property type="entry name" value="CLP_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Clp R" evidence="3">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH85920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="153" mass="16093" checksum="715ED094261FB563" modified="2015-07-22" version="1">MSTFDRYLQAVLLTAEAEAREDGSAAMEARHVLLAVAAQDGTEPQRVLAAAGLGRAELKAALDREFAHSLGAAGVAPGAFDLRATPDPGRRPQFGASLKLVLDRMAGAHRKKDLTPLHVLDALLRAEVGTVPRALDLAGVDRAALAARVREAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBS3</accession>
    <name>A0A0F7NBS3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ATP-grasp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_24695</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018126.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_24695"/>
    <dbReference type="EnsemblBacteria" id="AKH84874">
        <property type="protein sequence ID" value="AKH84874"/>
        <property type="gene ID" value="AA958_24695"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_24695"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5208"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013651">
        <property type="entry name" value="ATP-grasp_RimK-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08443">
        <property type="entry name" value="RimK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="2">
        <location>
            <begin position="110"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH84874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="297" mass="32396" checksum="C938BD8A0DA1A587" modified="2015-07-22" version="1">MKIGLLGWDYTGIDPDGPSLVEYGRERGHEMSFFTLEEIAYRTGSGGDVELSLRGEPAAAFDAILNRAKLYGDDWQDRVERLTMLSDTPGPRMFDPAEAWLTGYSKFQMAQRLAAAGLPVPPLRSVTTTAEVEAACAEWGPVIIKPSFGYRGQDVERIADYAAGKALAEELLSRHRTLVCQPYYPTEGGEYRITVAGEVAPINMLKLPAAGSWRCKTLEGSSFERFDAPDELIELSVAATRAMGLTLAGLDVLPTSDGYVILEVNAVPGFLSLLGREQHRQVLGGVFDWVERSMAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBT3</accession>
    <name>A0A0F7NBT3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_31190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019168.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_31190"/>
    <dbReference type="EnsemblBacteria" id="AKH85940">
        <property type="protein sequence ID" value="AKH85940"/>
        <property type="gene ID" value="AA958_31190"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_31190"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6591"/>
    <dbReference type="OrthoDB" id="337840at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046238">
        <property type="entry name" value="DUF6271"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19787">
        <property type="entry name" value="DUF6271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519940" evidence="1">
        <location>
            <begin position="16"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="437" mass="46834" checksum="23DF027212AD2338" modified="2015-07-22" version="1">MARICLTLPTNRACAATIAAVHEEAVHAAAHFGAEVHFLILDSAADRDRAGHAAAVAGLPRVPGVVVHHLGEAEQRTFLTAVLRRARVAGAGKLLRLLLPDAVSYGACTDRAFLLAAALGCGSVHRRDSDSRYQTAGGRPVFPVHHELATLGLPAAEAARRVDADALNPLHAPKPVSLVGASFVGEMSVDIAEIHDLDPAVYHDVVSLWAPPHWPEERKRALVEESFKGAGTEAFGGDHAVLGAVDPMRVDMCNVAFHRGVYEAVPLPPATDTIGSDYFLLHLVHDATLPGVLHNRHIVNYHTDERKTGAGFTAYQMRFAKFLLSMRYFNVVYDELAAAGAALLDDRHRLRAAAVGELVARSARLDRDENVMRLTALEIAYRKLGGTYAEFAGVLAARASGLPAEAARDMADFALLIAAWEPLVRASRATDVPGAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NC74</accession>
    <name>A0A0F7NC74_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AA958_25625</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018289.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_25625"/>
    <dbReference type="EnsemblBacteria" id="AKH85039">
        <property type="protein sequence ID" value="AKH85039"/>
        <property type="gene ID" value="AA958_25625"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_25625"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5403"/>
    <dbReference type="OrthoDB" id="1110723at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004236">
        <property type="entry name" value="Pept_S1_alpha_lytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001316">
        <property type="entry name" value="Pept_S1A_streptogrisin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035070">
        <property type="entry name" value="Streptogrisin_prodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02983">
        <property type="entry name" value="Pro_Al_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001134">
        <property type="entry name" value="Streptogrisin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00861">
        <property type="entry name" value="ALYTICPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 10" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519949" evidence="7">
        <location>
            <begin position="31"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="Pro_Al_protease" evidence="9">
        <location>
            <begin position="100"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="8">
        <location>
            <begin position="174"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="204"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="233"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="314"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="308"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001134-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001134-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AKH85039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="358" mass="35801" checksum="ABAA6DC58997A0C7" modified="2015-07-22" version="1">MRPQKSARLGGTFAALLLLGTAALGSTAAAAPPPADRSGQGVQADAATLALDADVTRTLGSDSAGTYLDADTGDLVVTVTDKAAAAEARAAGARAELVEHSAAELRSAMGAFEDRAKITGTSWGVDPATNQIAVQADSTVSAAEYAKLKRVAKSLDGAARVERVPGAFKKEVLGGDAIYGGGYRCSAAFNVTKNNARYFVTAGHCTNAGASWSATSGGAAIGTREGTSFPTNDYGIVRYTDGSSPAGTVNLYNGSTRDISSAANAVVGQAIQKSGSTTQVTSGTVTAVNVTVNYSDGPVYNMVRTTACSAGGDSGGAHFSGNVAYGIHSGSSGCSGTNGSAIHQPVTEALSAYGVSVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCE3</accession>
    <name>A0A0F7NCE3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_25865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018321.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_25865"/>
    <dbReference type="EnsemblBacteria" id="AKH85078">
        <property type="protein sequence ID" value="AKH85078"/>
        <property type="gene ID" value="AA958_25865"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_25865"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5447"/>
    <dbReference type="OrthoDB" id="2079019at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="13"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="66" mass="7173" checksum="71B6045D6CDB074C" modified="2015-07-22" version="1">MAKALLGYVGGTDPRLLAEMRRLQQRVQDLESELVRVQAENDMLAAAAAHNSESLLDVPQAEPALT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCJ4</accession>
    <name>A0A0F7NCJ4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 16">Succinate dehydrogenase flavoprotein subunit</fullName>
            <ecNumber evidence="5 16">1.3.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">AA958_22025</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>a quinone + succinate = a quinol + fumarate</text>
            <dbReference type="Rhea" id="RHEA:40523"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.3.5.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 16">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 16">Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (bacterial route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.1" evidence="5 16"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017689.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_22025"/>
    <dbReference type="EnsemblBacteria" id="AKH84427">
        <property type="protein sequence ID" value="AKH84427"/>
        <property type="gene ID" value="AA958_22025"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_22025"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4639"/>
    <dbReference type="OrthoDB" id="153138at2"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER01005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033765">
        <property type="term" value="F:steroid dehydrogenase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008177">
        <property type="term" value="F:succinate dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022900">
        <property type="term" value="P:electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003952">
        <property type="entry name" value="FRD_SDH_FAD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037099">
        <property type="entry name" value="Fum_R/Succ_DH_flav-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015939">
        <property type="entry name" value="Fum_Rdtase/Succ_DH_flav-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030664">
        <property type="entry name" value="SdhA/FrdA/AprA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011281">
        <property type="entry name" value="Succ_DH_flav_su_fwd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014006">
        <property type="entry name" value="Succ_Dhase_FrdA_Gneg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632">
        <property type="entry name" value="PTHR11632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02910">
        <property type="entry name" value="Succ_DH_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46977">
        <property type="entry name" value="SSF46977"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="SSF56425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01816">
        <property type="entry name" value="sdhA_forward"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01812">
        <property type="entry name" value="sdhA_frdA_Gneg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00504">
        <property type="entry name" value="FRD_SDH_FAD_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11 16" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10 16" id="KW-0274">FAD</keyword>
    <keyword evidence="9 16" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="12 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 16" id="KW-0813">Transport</keyword>
    <keyword evidence="8 16" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="18">
        <location>
            <begin position="7"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="Succ_DH_flav_C" evidence="19">
        <location>
            <begin position="467"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="480"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="14">
        <location>
            <position position="299"/>
        </location>
    </feature>
    <feature type="modified residue" description="Tele-8alpha-FAD histidine" evidence="15">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR611281-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR611281-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU362051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF02910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="AKH84427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="597" mass="65973" checksum="5A93ED88142C6DE8" modified="2015-07-22" version="1">MQIHKYDTVIVGAGGAGMRAAIEATKRPHGPGGPGDAPCRTAVLTKLYPTRSHTGAAQGGMAAALANVEEDNWEWHTFDTIKGGDYLVDQDAAEILAKEAIDAVLDLEKMGLPFNRTPQGRIDQRRFGGHSRNHGEAPVRRACYAADRTGHMILQTLYQNCVKEGVEFFNEFYVLDQLIAEDPETGLKRSAGVVAYELATGEIHVFQAKAVVYASGGNGKFFKVTSNAHTLTGDGQASVFRRGLPLEDMEFFQFHPTGIWRMGILLTEGARGEGGILRNKDGERFMEKYAPVMKDLASRDVVSRAIYTEIREGRGCGPEGDHVYLDLTHLPPEQLDAKLPDITEFARTYLGIEPYTDPIPIQPTAHYAMGGIPTNVRGEVLADNTTVVPGLYAAGEVACVSVHGANRLGTNSLLDINVFGRRAGIAAAEYAATADHVELPEDPAAFVVGEVERLRDSAGKERVAELRRELQETMDKNVMVFRTEQTIKEAVEKLAELRARYKNVSIQDKGRRFNTDLLEAIELGNLLDLAEVMAISALARKESRGGHYREDYPNRDDVNFMRHTMAYREVGDDGAETVRLDYKPVVQTRYQPMERKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCU0</accession>
    <name>A0A0F7NCU0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lycopene cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_31665</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019249.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_31665"/>
    <dbReference type="EnsemblBacteria" id="AKH86021">
        <property type="protein sequence ID" value="AKH86021"/>
        <property type="gene ID" value="AA958_31665"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_31665"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6687"/>
    <dbReference type="OrthoDB" id="1239213at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd05804">
        <property type="entry name" value="StaR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038732">
        <property type="entry name" value="HpyO_NAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033891">
        <property type="entry name" value="TTC38"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13454">
        <property type="entry name" value="NAD_binding_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="NAD_binding_9" evidence="2">
        <location>
            <begin position="2"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH86021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="897" mass="95178" checksum="C78A7306FD2E9865" modified="2015-07-22" version="1">MAVVGAGAAGALTAMQLCETAIRRSTPLELVLIDPASEAGRGVAYATPDPRHRLNVPAGGMSCYPDDPTHFVRWLRAHGEPAAAACDFVSRHRYGAYLADSLGQAVIRAHGTVAVSRLRTKATGCTWTAGGRAALRLADGRTQRADSVVLATGPAPGPRGWAPAALRASDRFVPDPWAPGALDALAGDAHAADDVLLVGTGLTAVDMALSLERSGRRVHAVSRGGELPRPHALTALPPLQADPGLPGLPLAELRAAVRRHVAAAVRAHGDWRPAVDGLRPLTQAMWARLSDDDRADFLARDASRWNVHRHRMPPATAESVQRALAARRLRLHSGQVRDVAEGPDGGLAVTLSGGRTLHVGWVVDCTGPGLRVEECADPLWRGLLADGTATPGPLGIGVATDAGRLRPGHAPAIRAGFPGAAPPPLFTLGAARRGELWETTAVPEIRVQAAEVAAAVLEPLREPVRGRRRPTDLNGLPVSTHAAAAAAYRTGLERLLKVRAGAGTALARAVELDPGFALGHAALALVGHECGADVDVPRALADAQRAARERADERERAFVEVVTRRIAGSGGDEALTRHLAAYPGDALALSVAVPTIAFSGVTDLDGAMARRLVERTTSAYEGHWFHTSLLAFMRQDDGRFDEAGELARRALAVEPAAGHAVHALAHVHYETGAHERGRDWLDGWIGDQGRGATHRAHFSWHVALHELALDDPDAVRRRWFAQLAPGRVNGVRALVDSGSLLWRARMSGCWTGEQPVEGVLAAVEREVVERPATPFTAMHSAVALTAAGDLAALRRLRTHAAGADPVQREVVAPLCEALEAVLEERWPDAVARLESIRPVLRKVGGSAAQREVVEETLLFALVSGGRCEAARRLLETRLDRRDSPADHRRLAALPGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCV1</accession>
    <name>A0A0F7NCV1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_27145</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018534.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_27145"/>
    <dbReference type="EnsemblBacteria" id="AKH85299">
        <property type="protein sequence ID" value="AKH85299"/>
        <property type="gene ID" value="AA958_27145"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_27145"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5720"/>
    <dbReference type="OrthoDB" id="1484726at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH85299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="220" mass="23290" checksum="CDF9CFDA8CD55E67" modified="2015-07-22" version="1">MTPGGITHVVWDWNGTLFDDADALIASTIEAFARQGLPPVTPERYRALHTQPIDAFYDRLLGRTVPAPLRAALHAAFHDAYLCRRPGIGLAPDALAALRTAARAGLTQSVLSMHPHDVLAELIERFALGPHLVRVDGQRGADAGHKRDHLAAHLRALDRPPGAVLLVGDSVDDARAAAAVGTRCVLYASGLHSGTALRAEGVPVTRTLEDALAVALGPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCX0</accession>
    <name>A0A0F7NCX0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase type 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_26655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018455.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH85218">
        <property type="protein sequence ID" value="AKH85218"/>
        <property type="gene ID" value="AA958_26655"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_26655"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5609"/>
    <dbReference type="OrthoDB" id="1515497at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="40"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="241" mass="26698" checksum="B99DB40CFEDB0AD3" modified="2015-07-22" version="1">MADDCFAHPQLAAIYDPLHPDRRDLDAYLRLTDEFGARRVLDIGCGTGVFAHLLADRGIEVVGVDPAQASIDVARAKPGGERVRWICGDATALPPLRAGLATMTANVAQAITDPQTWNETLRGARAALRPGGHLVFETRDPARRAWEEWTRERSSRVTEIPGVGSVASWVELIEVDLPLVTFRWTYEFAADGQVLTSDSTLRFRGREEVEQDLAAHGYAVEDVRDAPDRPGKEFVFLARRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDI6</accession>
    <name>A0A0F7NDI6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phenazine biosynthesis protein PhzF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_24090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018034.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_24090"/>
    <dbReference type="EnsemblBacteria" id="AKH84782">
        <property type="protein sequence ID" value="AKH84782"/>
        <property type="gene ID" value="AA958_24090"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_24090"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5077"/>
    <dbReference type="OrthoDB" id="1468060at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003719">
        <property type="entry name" value="Phenazine_PhzF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13774">
        <property type="entry name" value="PTHR13774"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02567">
        <property type="entry name" value="PhzC-PhzF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016184">
        <property type="entry name" value="PhzC_PhzF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00654">
        <property type="entry name" value="PhzF_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="1">
        <location>
            <position position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR016184-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="283" mass="29390" checksum="2DD2C924DA60C543" modified="2015-07-22" version="1">MTDVLRYTAFSTDPAGGNRAGVVLDAAGLSDERMAAIAADVGYSETAFLTPGPADEAGAGRSFTARYFSPAAEVPFCGHATVATAVALAERLGAGDFALHTRPGRVPVAVTEADGVLKATLSSVEPHVREAPAADVAEALAALRWSAAELDPALPPRIAFAGAHHLVLAAATRARLADLDYDFGRLRTLMEKLDLTTVQLVWRESPAVFHVRDPFPVGGVVEDAATGAAAAAFGAYLRELGLAAGQDRLALHQGHDMGSPSLLEVELRAGDPRVHVTGAAVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDK0</accession>
    <name>A0A0F7NDK0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AMP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_28325</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018733.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_28325"/>
    <dbReference type="EnsemblBacteria" id="AKH85499">
        <property type="protein sequence ID" value="AKH85499"/>
        <property type="gene ID" value="AA958_28325"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_28325"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5970"/>
    <dbReference type="OrthoDB" id="1015470at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="26"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="448"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH85499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="538" mass="59150" checksum="EEBF0F26589081E8" modified="2015-07-22" version="1">MTAEPSYTSGTGATALLGDTIGANLDRAIAAHPDREALVDVVSGRRWTYAEFGAAVDEVARGLLARGVAKGERVGIWAVNCPEWVLVQYASARIGAVMVTINPAYRVHELEYVLNQSGTSLLVASLAHKSSDYRRMVEQVRGSCPALRNVFYIGDSGWGRLIEAGRAVPPERVREREALLSCDDPVNIQYTSGTTGFAKGATLSHHSILNNGFFVGETLGYTEQDRVCIPVPYYHCFGMVMGNLAATSHGACMVVPGPSFDPAATLAAVEQERCTSLYGVPTMFVAELALPDFALYDLTSLRTGIMAGSPCPVEVMKRVVNEMHMAEVTICYGMTETSPVATQTRREDDLERRTATVGRVLPHIEVKVVDPVTGVTMPRGTTGELCTRGYSVMQGYWEQPERTAEVVDAGRWMHTGDLARMREDGCVEIVGRIKDMIIRGGENVYPREIEEFLYTHPKIADVQVVGVPDETYGEEILACVILSDPGHALSRRELAHYCENRLAHYKIPRHLRIMEEFPMTVSGKVRKVELREQFSAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDS4</accession>
    <name>A0A0F7NDS4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphatidylserine decarboxylase proenzyme</fullName>
            <ecNumber evidence="5">4.1.1.65</ecNumber>
        </recommendedName>
        <component>
            <recommendedName>
                <fullName evidence="5">Phosphatidylserine decarboxylase alpha chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="5">Phosphatidylserine decarboxylase beta chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="5" type="primary">psd</name>
        <name evidence="6" type="ORF">AA958_28620</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H(+) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CO2</text>
            <dbReference type="Rhea" id="RHEA:20828"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="EC" id="4.1.1.65"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
        <text evidence="5">Binds 1 pyruvoyl group covalently per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="5">Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the phosphatidylserine decarboxylase family. PSD-A subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.65" evidence="5"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018782.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_28620"/>
    <dbReference type="EnsemblBacteria" id="AKH85548">
        <property type="protein sequence ID" value="AKH85548"/>
        <property type="gene ID" value="AA958_28620"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_28620"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6029"/>
    <dbReference type="OrthoDB" id="891720at2"/>
    <dbReference type="UniPathway" id="UPA00558">
        <property type="reaction ID" value="UER00616"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004609">
        <property type="term" value="F:phosphatidylserine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00664">
        <property type="entry name" value="PS_decarb_PSD_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003817">
        <property type="entry name" value="PS_Dcarbxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033175">
        <property type="entry name" value="PSD-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35809">
        <property type="entry name" value="PTHR35809"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02666">
        <property type="entry name" value="PS_Dcarbxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00164">
        <property type="entry name" value="PS_decarb_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1 5" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="4 5" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0865">Zymogen</keyword>
    <feature type="chain" id="PRO_5023540444" description="Phosphatidylserine decarboxylase beta chain" evidence="5">
        <location>
            <begin position="1"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023540443" description="Phosphatidylserine decarboxylase alpha chain" evidence="5">
        <location>
            <begin position="187"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via pyruvic acid" evidence="5">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage (non-hydrolytic); by autocatalysis" evidence="5">
        <location>
            <begin position="186"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="modified residue" description="Pyruvic acid (Ser); by autocatalysis" evidence="5">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH85548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="217" mass="23575" checksum="EFC4C4F569BF46F0" modified="2015-07-22" version="1">MPHSPDNVPRRRIRLARGASPWLLPTLATAAVTAVRARRSGRWPDRLAAVPPAALAAGMLWFFRDPDREIAEGRVISPADGVVQSIMPWPDGRTRVAIFMSPLNVHVNRAPLAGTVRSVEHVPGGYVPAFNKESENNERVVWHLDTELGDVEMVQIAGAVARRIVPYVTGGTKVEQGERVGLIRFGSRVDVYLPQGIAPGVDVGQATTAGVTRLDRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDY5</accession>
    <name>A0A0F7NDY5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_24770</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018134.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_24770"/>
    <dbReference type="EnsemblBacteria" id="AKH84882">
        <property type="protein sequence ID" value="AKH84882"/>
        <property type="gene ID" value="AA958_24770"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_24770"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5223"/>
    <dbReference type="OrthoDB" id="1146366at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004814">
        <property type="term" value="F:arginine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006420">
        <property type="term" value="P:arginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005148">
        <property type="entry name" value="Arg-tRNA-synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036695">
        <property type="entry name" value="Arg-tRNA-synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008909">
        <property type="entry name" value="DALR_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03485">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05746">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01016">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00836">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55190">
        <property type="entry name" value="SSF55190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arg_tRNA_synt_N" evidence="7">
        <location>
            <begin position="4"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="DALR_1" evidence="6">
        <location>
            <begin position="214"/>
            <end position="346"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH84882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="346" mass="35955" checksum="28BAB88DA19F62B2" modified="2015-07-22" version="1">MDPAELTGTVLRTVRSAAVGEFGAPVPARVVVERPRPGGSGDYATNAALQLAHAAGRDPLDVAALLRDRLAVQPGIAAVTVTGPGYLNITLLHEGDPVEDALAAGESFGHGDCLRGRSFRLVADEHPRALVLADSLRRLLLAAGASLGEQGDLVRVTGVAAPTGAGIGAGAGRGLGELPPDVLRWAFLRAPARQRPRLAPELLLRREANPLFRIQYAHSRTAALARAAAQLRIDTRVGTRADGPPAVPPAAPVRHTRSDGVLLAAIGELPAVVETAARRRAPDRLARHLDVLAGAFLGAEAAHPALPSGDEEPTAVHRARLRRAAAAGVALRNGLALLGIRAPRHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NE47</accession>
    <name>A0A0F7NE47_9ACTN</name>
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        <submittedName>
            <fullName evidence="13">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">AA958_25325</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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    </dbReference>
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        <property type="protein sequence ID" value="AKH84982"/>
        <property type="gene ID" value="AA958_25325"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000034283">
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="CBS_pair_CorC_HlyC_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044751">
        <property type="entry name" value="Ion_transp-like_CBS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005170">
        <property type="entry name" value="Transptr-assoc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03471">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="DUF21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01091">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4 8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="90"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="12">
        <location>
            <begin position="1"/>
            <end position="201"/>
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            <end position="280"/>
        </location>
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            <end position="341"/>
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            <end position="459"/>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AKH84982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="459" mass="48374" checksum="A170AE4FE3B599D4" modified="2015-07-22" version="1">MTEILLLLAALALTLACAIFVAAEFSLTTVERGDLERAAAAGERGAEGALKAVRRLTFQLSGAQLGITVTSLVIGMLAEPSLATLLRGPLAATGLGGTAAPVATLLGVALSTVVLMVIGELVPKNWAIARPLAVAKTVAGPQRGFTAAFGPFIRHLNSTANRVVRRVGLEPAEELASARTPDELVSLARHSAEGGALEPDSAELFVRTLHLHELTAENVMTPRVDVKALESGATALDAANLAHATGLSRFPVYAHSLDEVVGTVHIRDVLALEPRTRAATPVTELATEPLLVPETLPADRLLEQLRERRTMAVVIDEYGGTAGVATMEDIVEEVVGEVRDEHDPVELPDLQPAGVGADSRPTWDADGSVRLDQLAELGLEAPEGPYETVAGLIATLLARIPAKGDAVHLAGWRLDVLAVEHHRADRVRITAPAESAARAAPPRPTAAPDQRRPAEEVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NE57</accession>
    <name>A0A0F7NE57_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_03020</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_03020"/>
    <dbReference type="EnsemblBacteria" id="AKH86521">
        <property type="protein sequence ID" value="AKH86521"/>
        <property type="gene ID" value="AA958_03020"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_03020"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.644"/>
    <dbReference type="Proteomes" id="UP000034283">
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    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
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    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
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            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
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            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="85"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH86521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="293" mass="32295" checksum="1D8B75EAA193D1AC" modified="2015-07-22" version="1">MAGSPPATPAPRPRRAPRPGRILLVAVLTAAALYFLLPVYWLVIAATKSNDSLYGSFGLWFDDPRLWDNLSRVFSYDGHVYLRWMLNSLLYAGVGAVLATLLSAAAGFALAKYNFAGREAVFTFVLAGVLLPSTALALPLYLMFSKLELTNTYWGVLIPSVVSPFGVYLCRIYAEAAVPDTLLEAARVDGAGEGRIFFSLVLRIMTPALVTVFLFQFVHIWNNYFLPLVMLSDDRKYPITLGLVTWQQAADRVPELTQYTIGGAFVSVIPLAVAMLVLQRFWQTGLTEGSVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NEF6</accession>
    <name>A0A0F7NEF6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_10265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86661">
        <property type="protein sequence ID" value="AKH86661"/>
        <property type="gene ID" value="AA958_10265"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_10265"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2163"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="8"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="312" mass="33572" checksum="02E9181D696FE9F4" modified="2015-07-22" version="1">MAGAALALAAAGPATAGDGTGQGGSDQIGSRVDFSHSSPGSGETSPMTPIGGSWSPPVCWYEPRYTPDQMDDYVHENYNAEHNATSAISELVTDDSTFDLRKDEEGLWWELVYQDDGVTAEECPATKSFMFIGPEEPAEPNTDVIDPETLAALAYNETELPAPPVDLKPNADRQVVNLETLAVLDPAELQRVWVTAFIDPPGMERIAATTVATPQRLRLEAGTEYADPNVCEYDLVRKGGGFAVDTEDAGCNITYRKSSGEGTYELEASLTWNVNWNPTGSPDGTPVHEDFPDGQSATEIPVTVKEIQTVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NEL4</accession>
    <name>A0A0F7NEL4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_30330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019031.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_30330"/>
    <dbReference type="EnsemblBacteria" id="AKH85803">
        <property type="protein sequence ID" value="AKH85803"/>
        <property type="gene ID" value="AA958_30330"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_30330"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6408"/>
    <dbReference type="OrthoDB" id="867226at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="6"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="488" mass="51853" checksum="10A09974DB8D8584" modified="2015-07-22" version="1">MAKGAIVVGAGPVGLMSAAELRLGGVDVMVYDRLPAPSGESRGLGFTGRTAEILDQRGLLSRLGPFRWGQQGHFGGVRIDFDLLEESHFGVMGLPQSRTEQLLGDWAAELGVQIRRGYEVTGFAETGTGVTVQYQGPDGPGEDTAQYLVACDGSHSVVRERAGIAFPGDPATRGLYLADIVGAEIQPRPIGERIKGGGMVLAVGLGDGVTRIVIHEPGVRPHHGEGSLTFTEVADAWQRMTGDDIHHAEPRWMAALTDATGLAETYRAGRVFLAGDAAHDHAPLGAQGLSVGLQDAVNLGWKLAAVVKGRAPEELLDTYHAERHPVGRHLLRNVHAQSLLYLNAEMEPLRAVMHELVQLPEAARQLAGQVSGLHIRYDVGAEGHPLLGLRLAPGYELACADGTVVRVAELLHAGRGVLILTSDVGLRQKTAARWADRIDVVVGSWVRENGPEAALLRPDGHVAWAAPDGGDLEDGLTRWFGPGTAPEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-08-12" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NEM4</accession>
    <name>A0A0F7NEM4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_19540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020255.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86910">
        <property type="protein sequence ID" value="AKH86910"/>
        <property type="gene ID" value="AA958_19540"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_19540"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4118"/>
    <dbReference type="OrthoDB" id="1459004at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="216"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="326" mass="35653" checksum="857EBDF697E3E95E" modified="2015-07-22" version="1">MHRVVVLALEGVYPFEMTIPVRIFGTAANSRGEPLYEVLTCSLDGRPVVTSADFSLTVQHGGEVLPSADTVVIPPFVCGPDEEREWLPEGLAEALDRIRPEARVMSICTASYALAAAGLLDGRPATTHWNEAPRFKRAFPEVRVDADVLFVDDGRVLTAAGVAAGVDLCLHLVRRDHGSEIANRVARMCVVPPWREGGQAQYIERPMPEPSQSSTSHTRAWALERLHEPLSLSGMAAHAGMSVRTLTRHFHSEVGTTPGQWLAQQRLDHARRLLETTDWTVDVIADRAGLGTGASLRQRLTAAIGVSPTAYRQTFRARDTEGLPTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NEM5</accession>
    <name>A0A0F7NEM5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alkylhydroperoxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_30400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019041.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_30400"/>
    <dbReference type="EnsemblBacteria" id="AKH85813">
        <property type="protein sequence ID" value="AKH85813"/>
        <property type="gene ID" value="AA958_30400"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_30400"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6423"/>
    <dbReference type="OrthoDB" id="1893149at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004675">
        <property type="entry name" value="AhpD_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00778">
        <property type="entry name" value="ahpD_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMD" evidence="1">
        <location>
            <begin position="14"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="152" mass="16215" checksum="038DE2D95351CD80" modified="2015-07-22" version="1">MQARIASPTAAVPGAVPALRALGEALKRSGVPESTLLLVYLRTSQINGASWNVDRHAAEMRAAGESPERIAAVAAWRDAPYYSDAERAALLLAESAARLGDRPDAVPDAVWHEAARHFDESQLATLVLASGFCNLWHRVVATTRRPAGQPPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NER2</accession>
    <name>A0A0F7NER2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phytanoyl-CoA dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_31185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_31185"/>
    <dbReference type="EnsemblBacteria" id="AKH85939">
        <property type="protein sequence ID" value="AKH85939"/>
        <property type="gene ID" value="AA958_31185"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_31185"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6590"/>
    <dbReference type="OrthoDB" id="1070946at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="368" mass="41671" checksum="8D60369DD9BE3261" modified="2015-07-22" version="1">MPDPGPYLYRAASDIPYFSADGESYLARTPLRDIRKSRPLRVLSDEDYAHWQTYGYVVVREAIPAEAAALLLDFAWDFQGLDPDRPETWYEDREFRSDLDRDLHVYGFVEAYQHQLIWDSRQTRRVYDAFADVWDCDELWVTLDRLNLNPPNVGNRSRTLIEPTDTGFDIELHWDVDTTLAVLPQRVQGIIALNDTRPDHGGFQCAPELFRDFEKWKLAQPAGRDPIRPDTDPAEFPVVRPELAAGDLLIWNGLLAHGVAANASESGVRAVQYLAMMPALEEHERLRRSRVESWRTLSTPDWNATLLGDSRRHESERYGPAALTGLGRKLLGLDSWRAPAPDAAPGGTEEGRAGAEPERTGEPWHASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFP0</accession>
    <name>A0A0F7NFP0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_33135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019489.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_33135"/>
    <dbReference type="EnsemblBacteria" id="AKH86264">
        <property type="protein sequence ID" value="AKH86264"/>
        <property type="gene ID" value="AA958_33135"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_33135"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.7000"/>
    <dbReference type="OrthoDB" id="1848269at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018729">
        <property type="entry name" value="DUF2269_transmembrane"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10027">
        <property type="entry name" value="DUF2269"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="158" mass="16061" checksum="80FEAA8F82982F84" modified="2015-07-22" version="1">MTKVLLSVHVLAAILAVGPIAVAASVFPRIARESAAADPAHRDRTPAFLHRVCRAYAVVGLAVPAFGVATGAQLGVLTDAWLLASIVLTAGAAALLALAILPGQQRMLTRVSGDAPAVEGDGLRPAAGRLAMLTGVFNLLWAVVVVLMIVRPGSTTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFQ0</accession>
    <name>A0A0F7NFQ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_33190</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019499.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_33190"/>
    <dbReference type="EnsemblBacteria" id="AKH86274">
        <property type="protein sequence ID" value="AKH86274"/>
        <property type="gene ID" value="AA958_33190"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_33190"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.7011"/>
    <dbReference type="OrthoDB" id="1268974at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003313">
        <property type="entry name" value="AraC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037923">
        <property type="entry name" value="HTH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02311">
        <property type="entry name" value="AraC_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
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        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51215">
        <property type="entry name" value="SSF51215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="4">
        <location>
            <begin position="179"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH86274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="303" mass="33146" checksum="F8EAE82521AF659D" modified="2015-07-22" version="1">MHRLEVPAPEVLPFALGSFDSIGPLSRAGFPHRHTFHEIVYVRAGRGHHVVDQRRWPITPPHLGIVTPGQVHHWEGAAGLDGWVMIFTEDFLLPTPGDRDRLRELARVSWLSPAPRSAGILAALFAEMAREYAGRAPGFISVLQSYLHVLLIRADRLSRTARTAPEGGGDAWPAAGRAAEIARRFDRLLTEPGAAVAELSVRGCAASVGVSVGYLNEAVKRVTGLTPGHLIRQAQAREAKRLLAATDLTVRQVARLAGFSDPAYFSRFFRRETGSSPGDYRRGTRADHHDRRILSIDCPGGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFR7</accession>
    <name>A0A0F7NFR7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ParB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_30385</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_30385"/>
    <dbReference type="EnsemblBacteria" id="AKH87146">
        <property type="protein sequence ID" value="AKH87146"/>
        <property type="gene ID" value="AA958_30385"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_30385"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6419"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003115">
        <property type="entry name" value="ParB/Sulfiredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036086">
        <property type="entry name" value="ParB/Sulfiredoxin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02195">
        <property type="entry name" value="ParBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00470">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110849">
        <property type="entry name" value="SSF110849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ParB" evidence="2">
        <location>
            <begin position="14"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH87146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="326" mass="34999" checksum="B4C947561DA992CE" modified="2015-07-22" version="1">MLALREAVRDLPVEKVPVASLVVTFSPRAAGVDAGYALALSEVEAELPPILVHRGRMAVIDGRHRLRAARLNGAAYIGTRFFDGSESDARLLAVAMNVAQGLPLSRGDRIASALRILTARPQWSDRSVAAVAGLSARTVAELRGRARGQAHDAPRIGLDGRRRPFRSAQGRELAAKLLGEEPGASLRSVARRAGISPATVADVRDRLRRGDDPVPLGQREEPAAERPAREPAPPPVPALSPGELFVIFDSLCRDPSLRMTETGRTVLRMLDACHLIARDREKITVNLPPHCREQLAELLRGYAGLWRDLAGELGAGRAAGAVGAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFW4</accession>
    <name>A0A0F7NFW4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_32485</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_32485"/>
    <dbReference type="EnsemblBacteria" id="AKH87196">
        <property type="protein sequence ID" value="AKH87196"/>
        <property type="gene ID" value="AA958_32485"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_32485"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6856"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="PTHR21240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519497" evidence="2">
        <location>
            <begin position="24"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="Amidohydro-rel" evidence="3">
        <location>
            <begin position="87"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH87196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="375" mass="41906" checksum="974870AB3A8ABE90" modified="2015-07-22" version="1">MGRRGFLAASTALGAGAGLSAYAAVSAADGNKTADKTADIALRDRDLPFIGTEETFSTPTLLKLNSINQDHIAFLEEIGLSDLGQRRIGDMDAGGLNVQILSAHTPSVQNVPGQRGIDLAYRLNRQLVDGPIAKYPGRFKAFATLPLQSPEAAADELERSVREDGFLGALTNGHIAKKYLDHPDFEPVLARAVALDVPIYLHPGYPADEVFKIYYSTTRSEYTEDYQDYILSGSGYGWHQEVLTQCIRMITYGVFDRFPKLKIIIGHMGEGLPFYYERIVNDMGEPTEDSLEKPIGQYFQDNFWVTTSAFPQTELLHLLLKYISVDRVMFATDYPFADIKEQTDWFRGVDLPREDKEKIAFRNAEKLFGMKVPVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFY0</accession>
    <name>A0A0F7NFY0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-oxoadipate:succinyl-CoA transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_29260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018881.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_29260"/>
    <dbReference type="EnsemblBacteria" id="AKH85652">
        <property type="protein sequence ID" value="AKH85652"/>
        <property type="gene ID" value="AA958_29260"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_29260"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6169"/>
    <dbReference type="OrthoDB" id="1380130at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008410">
        <property type="term" value="F:CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004165">
        <property type="entry name" value="CoA_trans_fam_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01144">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00882">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH85652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="254" mass="26527" checksum="4B36F25EDE77658B" modified="2015-07-22" version="1">MSGWTSDELMTVNAARALADARTCFVGIGLPSTAANLARRTARPDLVLVYESGTIGSRPTRLPLSIGDGELADTADAVVSVPEMFNYWLQAGRIDVGFLGAAQLDRYANINTTVVDRGPDRPQGRLPGAGGAPEIAASCGEVLIVLRHSPRSFVERLDFVTSVGHGSGPGDRRRLGLRGKGPTAVITDLGVLRPDPATAELVLTELHPGVTAEQVRAATGWELKTADAVGTTVPPTAQELSALRALKTAGRASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NG61</accession>
    <name>A0A0F7NG61_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Chaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_33410</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019538.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86313">
        <property type="protein sequence ID" value="AKH86313"/>
        <property type="gene ID" value="AA958_33410"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_33410"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.7056"/>
    <dbReference type="OrthoDB" id="1990300at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000390">
        <property type="entry name" value="Small_drug/metabolite_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045324">
        <property type="entry name" value="Small_multidrug_res"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30561">
        <property type="entry name" value="PTHR30561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00893">
        <property type="entry name" value="Multi_Drug_Res"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH86313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="105" mass="10690" checksum="E86A02AAE5D57EAD" modified="2015-07-22" version="1">MPWIFLLIAAGLELVWASALNQSDGLTRLWPSTIGLVMAMASVVVLTMALRSLPVGTAYAVWVGLGSLGVAAVGILALGESASPARLACLGLILAGVIGLKFVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NG67</accession>
    <name>A0A0F7NG67_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Branched-chain amino acid ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_34050</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the leucine-binding protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019646.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_34050"/>
    <dbReference type="EnsemblBacteria" id="AKH86424">
        <property type="protein sequence ID" value="AKH86424"/>
        <property type="gene ID" value="AA958_34050"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_34050"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.7195"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028081">
        <property type="entry name" value="Leu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000709">
        <property type="entry name" value="Leu_Ile_Val-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13458">
        <property type="entry name" value="Peripla_BP_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00337">
        <property type="entry name" value="LEUILEVALBP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peripla_BP_6" evidence="3">
        <location>
            <begin position="28"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH86424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="372" mass="38378" checksum="78FDA00E39B28FE6" modified="2015-07-22" version="1">MLGLSLTACGGNLTSGGSTDSDSGTKGTIKLGMLTPLSGSSAAIGPNMRHGAQLSVDEINAKGGVDGRKLELTVEDEACDPKTAAAGAAKLVSAGIDISVGGYCSSATLPTLSIFNKANIPVIIPVANSTDLVAQKLPNVFLINGTGIQQAQAASQFLKDQGATGVALLDDNTSYSTDIAKRTEQDLKSLGVKVAGHQSVTAGESDYSGAVNAVIRAKADFVYWTGYYQEGGLIIKQLKAAGYQGKFMVADGSVDPKLIEIAGQRNAQGVFATMTQTPQTVPGGAAWAKKYKAKFGSAPGPYSTQAYDAVRVAAEAVRESGSTDGQAVIKALEAIDDFEIFSGSLKFTSEHTLIEGGFHILVVKGNGFTLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NGC6</accession>
    <name>A0A0F7NGC6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Hemerythrin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_30325</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019030.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH85802">
        <property type="protein sequence ID" value="AKH85802"/>
        <property type="gene ID" value="AA958_30325"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_30325"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6407"/>
    <dbReference type="OrthoDB" id="1701106at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012312">
        <property type="entry name" value="Hemerythrin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01814">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hemerythrin" evidence="2">
        <location>
            <begin position="13"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH85802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="221" mass="24182" checksum="9101205CDD557682" modified="2015-07-22" version="1">MGDTTKNAGALLYEEFVAIHEVLRRGTAMVADAYKALARGDEVDPGELAEAARWLLAFTHAHHRAEDDVFWPLLHALYPRQKTELAELSAEHAVLDQALNDLEAAALGPSHRDGEPSPGPTGRASEAATRVRDIMAGHLAAEEAVVEGLFPGVPEADVVWLREAFIQGSPRFGLHLMFGLLEDPEPARGQDLLRENFPPALRDAREGLLEQYRITREALAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NH62</accession>
    <name>A0A0F7NH62_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNA polymerase sigma 70</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_08610</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Interacts transiently with the RNA polymerase catalytic core formed by RpoA, RpoB, RpoC and RpoZ (2 alpha, 1 beta, 1 beta' and 1 omega subunit) to form the RNA polymerase holoenzyme that can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86618">
        <property type="protein sequence ID" value="AKH86618"/>
        <property type="gene ID" value="AA958_08610"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_08610"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1816"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="12"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="7">
        <location>
            <begin position="115"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH86618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="292" mass="31509" checksum="446616158B312330" modified="2015-07-22" version="1">MYESELLAGRFEEKRPRLQAVAHRMLGSAEEAEDAVQEAWIRLQRADVAAVENLDAWLTTVVGRVCLDILRARTRREELFEELLDQHADPPPAAPADEAADPEQAAMLADSVGKALLVVLDTLEPDERLAFVLHDMFAVPFSDIAAVIERSPAATRQLASRARRRVQGASPLPDLRRQHKVVSAFLTAARKGEFDRLLALLAPDVAMRADATAVSIGAAEATHGAEGVARIFSGGAQGARLALVDGAVGAVWQAKARTIVAFGFTLEDGRITAIELTGEPARLEELDIAVLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NHJ5</accession>
    <name>A0A0F7NHJ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_32865</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86217">
        <property type="protein sequence ID" value="AKH86217"/>
        <property type="gene ID" value="AA958_32865"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_32865"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6943"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH86217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="70" mass="7380" checksum="35D8C2221C05852A" modified="2015-07-22" version="1">MLGGLTEHLPGVVGIAIEDGHQNPAGLIDHRPGPDGLFELGVLLAQLGQPVADPRRQLAEGRAGLSRRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NIQ4</accession>
    <name>A0A0F7NIQ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_10510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019940.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_10510"/>
    <dbReference type="EnsemblBacteria" id="AKH86672">
        <property type="protein sequence ID" value="AKH86672"/>
        <property type="gene ID" value="AA958_10510"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_10510"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2214"/>
    <dbReference type="OrthoDB" id="1271858at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="374"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="421" mass="42391" checksum="7C6E2F0C52C4BBF7" modified="2015-07-22" version="1">MTPARAGAPTAGPGTASAPGPALRRRLDALRGAGVEARALDARALAALAANPGCRRRTLLDGAGIDKGALAEALGRPAPFGQSQFAFARGNAFEARITADGGAELLSLLAERTGEVPPEPAAVRVPDLAAPGPRGRTERTRLAIAEAVAAGGWTLLRHPMVSLEVAGAPVYLEPDAAVVGPDGRCRVVEIKSFPILDGAADPAKVGAAARQAAVYVLALRPHCEVHHDVLLVCPKDFSNQPVAEPVDVRKQLAATRRQLARLTRLEAIAATLPADLTLDVRQPPPRLVTAVESVPAAYAPECLAACELAFHCRAQARERGDVTALGRGVRGDLGGLRTVAEVVTAASGGAPPAGGADAEEGVAGAAAAGRPAAGPAAAARAVAPEADQAGPSPEDPAVAALRRAAVLRAEALAAAEGGGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NIR6</accession>
    <name>A0A0F7NIR6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_11525</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_11525"/>
    <dbReference type="EnsemblBacteria" id="AKH86692">
        <property type="protein sequence ID" value="AKH86692"/>
        <property type="gene ID" value="AA958_11525"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_11525"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2425"/>
    <dbReference type="OrthoDB" id="1857862at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014322">
        <property type="entry name" value="RNA_pol_sigma-B/F/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02980">
        <property type="entry name" value="SigBFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00715">
        <property type="entry name" value="SIGMA70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RNA_pol_sigma70" evidence="5">
        <location>
            <begin position="86"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH86692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="283" mass="31350" checksum="4E2129A1AD7EC7AA" modified="2015-07-22" version="1">MANAADAAGTAASFTGSIDELEGIAFDEVAPADARAMSKTLFDRLGTLEEGTHEYSYVRNTLIELNLALVKFAASRFRSRSEPMEDIIQVGTIGLIKAIDRFEPARGVEFPTFAMPTIIGEIKRFFRDTSWSVRVPRRLQELRLDLAKAGDELAQQLDRAPTVDELAERLAIGRDEVVEGMAASNAYTASSLDAQPEEDDSESTLADRIGYEDHGLEGIEYVESLKPLIAELTPRDRKILSLRFVANMTQSEIGEELGISQMHVSRLLSRTLVRLRKGLMVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A097H0Y8</accession>
    <name>A0A097H0Y8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phenazine biosynthesis protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Putative enzyme of phenazine biosynthesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cnq734</name>
        <name evidence="4" type="ORF">AA958_30745</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="ChemBioChem" volume="15" first="2385" last="2392">
            <title>A Membrane-Bound Prenyltransferase Catalyzes the O-Prenylation of 1,6-Dihydroxyphenazine in the Marine Bacterium Streptomyces sp. CNQ-509.</title>
            <authorList>
                <person name="Zeyhle P."/>
                <person name="Bauer J.S."/>
                <person name="Steimle M."/>
                <person name="Leipoldt F."/>
                <person name="Rosch M."/>
                <person name="Kalinowski J."/>
                <person name="Gross H."/>
                <person name="Heide L."/>
            </authorList>
            <dbReference type="PubMed" id="25224759"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CNQ-509</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PhzA/PhzB family.</text>
    </comment>
    <dbReference type="EMBL" id="KJ451627">
        <property type="protein sequence ID" value="AIT42135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019094.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH85866">
        <property type="protein sequence ID" value="AKH85866"/>
        <property type="gene ID" value="AA958_30745"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_30745"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6499"/>
    <dbReference type="OrthoDB" id="1644255at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004964">
        <property type="entry name" value="PhzA_PhzB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03284">
        <property type="entry name" value="PHZA_PHZB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIT42135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH85866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="168" mass="19555" checksum="D10BE5BE9E4C5C2E" modified="2015-01-07" version="1">MTPSVSRPPDTAAPVFTDHHDLRARNLLAVEQYMRTGAEARLRRYTLYTDDGTASLFYTDMGRPIVVRGREKLKRHGELSMQVLPDWQWHDVQIYQTQDPSVIWVECQGEGTIRFPGYPHGRYRNHFIHGFTLSDGHILASREYTNPIEHMRALSIETPHIERDWIPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MXA5</accession>
    <name>A0A0F7MXA5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_00275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH80860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014226.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_00275"/>
    <dbReference type="EnsemblBacteria" id="AKH80860">
        <property type="protein sequence ID" value="AKH80860"/>
        <property type="gene ID" value="AA958_00275"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_00275"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.65"/>
    <dbReference type="OrthoDB" id="1859760at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="9"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH80860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="368" mass="38164" checksum="31F9D002E94B7DED" modified="2015-07-22" version="1">MRFQAAVLRAYENPFTVEEVVLRTEPAAGEILVEIAGTGMCRTDLAVRRSAGRSPVPAVLGHEGAGVVVRTGGGPDAAIGVGDHVVLSFDSCGHCRTCRGAAPAYCDSFASLNLFGGRKEEPPRLTDATGQALAPRWFGQSSFAEYALVAARNAVRVDPVLPLELLGPLGCGALTGAGAVLNTFGAGPGDTLVVLGAGAVGLTAVMAATAAGVLTVAVDRHPDRLASADRFGATPLPAASPDLAGRIRRLTDGGAQYALDTTASPPLIHRALHALRPTGTLGLVARLHTPLALEPGMLEGGRSIRHICEGDAVPGVLIPRLIGLWQAGRFPFDQLIRTYPLAGINEAERDLDAGRVVKPVLLPERTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MXR4</accession>
    <name>A0A0F7MXR4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LacI family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_01355</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014400.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH81035">
        <property type="protein sequence ID" value="AKH81035"/>
        <property type="gene ID" value="AA958_01355"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_01355"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.299"/>
    <dbReference type="OrthoDB" id="1796334at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="4"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH81035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="347" mass="36695" checksum="66E8DAC32A82F31F" modified="2015-07-22" version="1">MGGPTVYDVAERVGVSIATVSRVYRSPESVRSETRERVLSAARELGYVPSASARGLASRVTGVLGLCFPDFAEPAADDASDAQGTELSLYGDEVIRGMERAARRRGYALLISASPAGRAGESMAEIAGRVDGLALLAQQWPAAELDVVSRRLPLVVLAGQRHPGLDRVEVANFDGQLALTRHLLSEHGRHRLAFLGGPEDSPDAEARFRGFQAALLEEGLEVPERPDTRGDLTLAAGRKAVAELLDRDGPRPQGLVCANDQMAVGALQALAERSIAVPGDMSVTGFDGIPLSGAVSPPLTTVRQPMGRLGEEAVEVLLARLADRTLPVESRTLPTVLVRRASCGCPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MXX7</accession>
    <name>A0A0F7MXX7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Beta-lactamase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_01745</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014464.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_01745"/>
    <dbReference type="EnsemblBacteria" id="AKH81100">
        <property type="protein sequence ID" value="AKH81100"/>
        <property type="gene ID" value="AA958_01745"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_01745"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.381"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008757">
        <property type="entry name" value="Peptidase_M6-like_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05547">
        <property type="entry name" value="Peptidase_M6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519041" evidence="2">
        <location>
            <begin position="35"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase" evidence="3">
        <location>
            <begin position="79"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M6" evidence="4">
        <location>
            <begin position="428"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="492"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH81100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="591" mass="64259" checksum="5C34C0CAF0132F0B" modified="2015-07-22" version="1">MTGQLGRRRFAAGVVATGGALFVVPGSTGLPAHAAEASSGAPVLRRGSGARAGLLEPHLRQLVADAETFLGPSPKYPWYAGAVILAGRGRTVALERAIGKAVRYERYDEATDTGVELPPEQQVDMSMDTVFDLASVSKLFTSLLAVQQIERGALTLEAPVASYLPEFGAAGKQDVTVLQLLTHTSGFASWIPLYAEPTWDAKLARLWREAPVNPPGTKYLYSDLNLISLQLVLEKITGKTLDRLLADEITGPLGLEHTRYNPPAAWLPRIAATEDARKPWSGLDRGMVRGEVHDENAYSFGGVAGHAGLFSTAWDLAILCRTLLNGGAYGRTRILERESVELMFTDFNTDFPGDEHGLGFELYQHWFMGAMATPESAGHTGFTGTALVIDPTTDTFLVLLGNSVHPVRSWRSGSAPRAAAGTNLARAVAVRPEDGRTAWFSGTASQKTSTLTLPEVTVRDAAAGLEFALWWDTEPQWDKVYLEASADDGGSWEPVPFSTRRPRGGGVREHAEGTADGWSGRVWHRASAELGAWRGRPVRLRWRYVTDRQYVGRGVYVDDVRVTDGRRVLFDDGRRGDAERVETDGWTASAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MY81</accession>
    <name>A0A0F7MY81_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lactate utilization protein B/C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_02245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014549.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_02245"/>
    <dbReference type="EnsemblBacteria" id="AKH81185">
        <property type="protein sequence ID" value="AKH81185"/>
        <property type="gene ID" value="AA958_02245"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_02245"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.482"/>
    <dbReference type="OrthoDB" id="1580190at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024185">
        <property type="entry name" value="FTHF_cligase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003741">
        <property type="entry name" value="LUD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02589">
        <property type="entry name" value="LUD_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LUD_dom" evidence="1">
        <location>
            <begin position="103"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="212" mass="22326" checksum="1A79DF4153612D9B" modified="2015-07-22" version="1">MSSSRETILARVRAATRDTAGTPEPAVPRDYLRVHGDRSPAESADLLAENLADYRALVHRTDAGGLPALLARLFAGRGTRTLLVPDGLPPAWTAAVGATRVPDTAASTARDLDAVDSVLTGCALAVAETGTIVLDAGAGQGRRRITLIPDHHVCVVRVPEQVVDSLPQAMERLDPARPQTWISGPSATSDIELDRVEGVHGPRTLEVVLVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MYS1</accession>
    <name>A0A0F7MYS1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sporulation protein SsgA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_03395</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell septum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SsgA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018836768.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_03395"/>
    <dbReference type="EnsemblBacteria" id="AKH81385">
        <property type="protein sequence ID" value="AKH81385"/>
        <property type="gene ID" value="AA958_03395"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_03395"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.720"/>
    <dbReference type="OrthoDB" id="1627707at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.31.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006776">
        <property type="entry name" value="SsgB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038658">
        <property type="entry name" value="SsgB_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04686">
        <property type="entry name" value="SsgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0749">Sporulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH81385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="137" mass="14834" checksum="7D3E67C65350A2DA" modified="2015-07-22" version="1">MNHTVSCELHLRLVVSSESSLPVPAGLRYDTADPYAVHATFHTGAEETVEWVFARDLLAEGLHRPTGTGDVRVWPSRSHGQGVVCIALSSPEGEALLEAPARALESFLKRTDAAVPPGTEPRHFDLDTELSHILAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MYX1</accession>
    <name>A0A0F7MYX1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SseB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_03815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014817.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_03815"/>
    <dbReference type="EnsemblBacteria" id="AKH81460">
        <property type="protein sequence ID" value="AKH81460"/>
        <property type="gene ID" value="AA958_03815"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_03815"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.802"/>
    <dbReference type="OrthoDB" id="1461900at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009839">
        <property type="entry name" value="SseB_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07179">
        <property type="entry name" value="SseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SseB" evidence="1">
        <location>
            <begin position="22"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="251" mass="24637" checksum="48DF3A969A83168A" modified="2015-07-22" version="1">MSLKNIPDPGFAADDGSADPGLAAALTAYAEAPDDPAAGVRVLAALAGTRVLVPVVALLGEAEEGPDRLRRDKTSDMAVPTLEVPGGRRALPAFTSTAALARWDPAARPVAVALPQAVQAAVAERADTVVLDVAGPVPYELTGPALLAAAEGRGSTDPLADPGVVAAVTAVVSGVAGIRAASLARAGEADGTLALVPAAGTAPAAVARAVAEALAADATLRARLVRGLDLALLPPDTPLPGAPLPLRPGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MZ17</accession>
    <name>A0A0F7MZ17_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">M20_dimer domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_04190</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014880.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_04190"/>
    <dbReference type="EnsemblBacteria" id="AKH81525">
        <property type="protein sequence ID" value="AKH81525"/>
        <property type="gene ID" value="AA958_04190"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_04190"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.879"/>
    <dbReference type="OrthoDB" id="906744at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00758">
        <property type="entry name" value="ARGE_DAPE_CPG2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="2">
        <location>
            <begin position="204"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH81525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="444" mass="47934" checksum="432E704C5DCBE9C2" modified="2015-07-22" version="1">MSQPENARGGTVERAESEVVDLCRELIRIDTSNYGDHSGPGERAAAEYVAEKLAEVGLEPEIFESHPGRASTVARIEGEDSSRPALLIHGHLDVVPANAADWTHDPFSGEVADGCVWGRGAVDMKDMDAMTLAVVRERLRTGRKPPRDVVLAFLADEEAGGLYGARHLVDTKPELFEGVTEAIGEVGGFSFTVNEDVRLYLIETAQKGMHWMRLTVDGTAGHGSMTNRDNAITELSEAVARLGRHEFPVRLTKSVRGFLDELGDALGVELDPEDMDATLARLGGIAKIIGATLRNTANPTMLGSGYKVNVIPGQATAHVDGRFLPGYEEEFLADLDRILGPRVKREDVHADKALETTFDGALVEAMATALKAEDPIARAVPYCLSGGTDAKSFDDLGIRCFGFAPLQLPPELDFAGMFHGVDERVPVAGLQFGVRVLDRFLDAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MZ27</accession>
    <name>A0A0F7MZ27_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_04265</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_04265"/>
    <dbReference type="EnsemblBacteria" id="AKH81535">
        <property type="protein sequence ID" value="AKH81535"/>
        <property type="gene ID" value="AA958_04265"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_04265"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.894"/>
    <dbReference type="OrthoDB" id="1981410at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH81535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="413" mass="43695" checksum="E2CAD27031356944" modified="2015-07-22" version="1">MFYLTPASAVIWEAGSGDITGAGAAESPAAAGNPGAVRAFQERFPGVSDEEAWRRIQAEDGRVALITRLAKDNAGTFGGSWYDGATDTQHLQATTAEAADRFAALAVDSGVKAEVHQVDYSYARLTAEAEQARAGEHRALGGAAKGDAAVDVEANRVVAGLAPADLKAARNETMAVPDTFQIRPRSTTDPSGLPIVDEVCNSRADCSKPLRGGISVKSPDVGCSLGFTAYENDHPKRKFAITAGHCGEKGERLKHSNWTIGNFDRVVFDNDSGTDVARARVENTHWLSSPLGWLYNPGDHDDPDPVTGRLTSESGIQNGQIVCLSAQHNPENGSDCGTIDGVVGNGYIRVVGHDACPGDSGGGWYRPSGGKRIAYGIHKGGAESCHGDQGGNYDYFTSLPRTEDRLDVTIHTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-10-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N057</accession>
    <name>A0A0F7N057_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_00035</name>
        <name evidence="2" type="ORF">AA958_34225</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH80828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH80828">
        <property type="protein sequence ID" value="AKH80828"/>
        <property type="gene ID" value="AA958_00035"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86443">
        <property type="protein sequence ID" value="AKH86443"/>
        <property type="gene ID" value="AA958_34225"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_00035"/>
    <dbReference type="KEGG" id="strc:AA958_34225"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.7"/>
    <dbReference type="OrthoDB" id="2210944at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH80828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="305" mass="32225" checksum="214BBD54CE870A36" modified="2015-07-22" version="1">MFQASSEPTVGRMCQIDPALAAQPLASRVGAFEVVLAFPPIENGLPAPGYVSWSITDTGEPIALGPAYFTAHAVFPSAPGTNESGMQDELKSAVTAIRFAAARLSDALRVEQPNVGMVGDIPRMLSLTARDTTRDLELKVSEPLSPGYPIVRGSPLLSAEAATNALGDGVSPPRALLSQARYLTQSTSSPQPGLAVLLSAVAAETYAKQTLQSCRPAGSSPSLRSLTEAHGKAVELYGPVTQGVIGRTLATEDPALWKGLGQLFSTRNKMAHRLKTPTHLDARRLVVVAMQAMDWLGTAVTQRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0E3</accession>
    <name>A0A0F7N0E3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Choline dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_07490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015450.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_07490"/>
    <dbReference type="EnsemblBacteria" id="AKH82100">
        <property type="protein sequence ID" value="AKH82100"/>
        <property type="gene ID" value="AA958_07490"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_07490"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1570"/>
    <dbReference type="OrthoDB" id="2018729at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021957">
        <property type="entry name" value="DUF3574"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12098">
        <property type="entry name" value="DUF3574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002518993" evidence="1">
        <location>
            <begin position="33"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="157" mass="17140" checksum="240B319EC0D5459D" modified="2015-07-22" version="1">MNLTKPRLRLAALALAAALAGAAAATAPAALADGDPTPPVALSQAAELEPYVQTHLMFGTVRPNGGPDVTDRQFRGFVDEVVTPRFPAGLTVDEVRGQYRDRHGTIERERSYEVYLLYPLTEAQEQDARIEEIRDAYTARFAQESVARVDEPARAGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0G6</accession>
    <name>A0A0F7N0G6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HxlR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_00515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH80898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014264.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH80898">
        <property type="protein sequence ID" value="AKH80898"/>
        <property type="gene ID" value="AA958_00515"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_00515"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.119"/>
    <dbReference type="OrthoDB" id="2057904at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="1">
        <location>
            <begin position="19"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH80898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="127" mass="14323" checksum="3507A174CDEB8925" modified="2015-07-22" version="1">MVTKHESGGLPGDADLRRADSLAREIFSDVANKWALLIIEALGERTLRFGELRNEVDGVSHKMLTQNLRTLERDGLVDRKVYPTVPPRVEYTLTEPGRALRATVDAMCGWTQQYLGHIEDARSRFDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0H8</accession>
    <name>A0A0F7N0H8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Prokaryotic ubiquitin-like protein Pup</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4 5">Bacterial ubiquitin-like modifier</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">pup</name>
        <name evidence="7" type="ORF">AA958_04005</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 5">Protein degradation; proteasomal Pup-dependent pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Strongly interacts with the proteasome-associated ATPase ARC through a hydrophobic interface; the interacting region of Pup lies in its C-terminal half. There is one Pup binding site per ARC hexamer ring.</text>
    </comment>
    <comment type="domain">
        <text evidence="5">The N-terminal unstructured half of Pup provides a signal required to initiate unfolding and degradation by the proteasome but is not needed for pupylation, while the C-terminal helical half of Pup interacts with ARC to target proteins to the proteasome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the prokaryotic ubiquitin-like protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018836875.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_04005"/>
    <dbReference type="EnsemblBacteria" id="AKH81491">
        <property type="protein sequence ID" value="AKH81491"/>
        <property type="gene ID" value="AA958_04005"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_04005"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.840"/>
    <dbReference type="OrthoDB" id="2059180at2"/>
    <dbReference type="UniPathway" id="UPA00997"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031386">
        <property type="term" value="F:protein tag"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019941">
        <property type="term" value="P:modification-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070490">
        <property type="term" value="P:protein pupylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02106">
        <property type="entry name" value="Pup"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008515">
        <property type="entry name" value="Ubiquitin-like_Pup"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05639">
        <property type="entry name" value="Pup"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03687">
        <property type="entry name" value="pupylate_cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="ARC ATPase binding" evidence="5">
        <location>
            <begin position="29"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="15"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="cross-link" description="Isoglutamyl lysine isopeptide (Glu-Lys) (interchain with K-? in acceptor proteins)" evidence="5">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH81491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="72" mass="8047" checksum="BC0F8BD82B5F4B76" modified="2015-07-22" version="1">MATKDTGGGQQKATRSQEEVEEQAQDAEVSEDLKERQEKLSEDVDSVLDEIDDVLEENAEDFVRSFVQKGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0J3</accession>
    <name>A0A0F7N0J3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_00695</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH80928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014294.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_00695"/>
    <dbReference type="EnsemblBacteria" id="AKH80928">
        <property type="protein sequence ID" value="AKH80928"/>
        <property type="gene ID" value="AA958_00695"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_00695"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.159"/>
    <dbReference type="OrthoDB" id="816674at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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            <end position="26"/>
        </location>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH80928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="400" mass="44390" checksum="652415758BE5AAA2" modified="2015-07-22" version="1">MSDTLSTPPRRLPTERPRPLDPPEELGRLRAEEPVSPLLYPDGHVGWLVTSHAAARKVLSDQRFSARGDIKKVPFELPSGGRPWEKVPPGFFMHMDPPDHTRYRRLLTGQFTVRRMKALEPRIEQITEEHLDEMERQGPPTDLVPSFALPIPSLAICELLGVPYGERQRFQDHSTTVMRIGSSGEEVAAAFAAIYGLIHELVQLKHKEPEDDLLSGLIATGELNDAELTGIGMLLLMAGHETTASMLSLGTYALLRHPGEVKRLREDPELFGNAVEELMRYLTIAQFGVPRTALEDVELEGKLIKAGDGVTVSLSAANRDPGRFGDADSFDVSRSTSGHMAFSYGIHQCLGQQLARVEMRIAYSALFRRFPDLRLAVEPEEVPLRAEATMYAASSLPVAW</sequence>
</entry>
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    <accession>A0A0F7N1R6</accession>
    <name>A0A0F7N1R6_9ACTN</name>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="12"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="239" mass="24678" checksum="6E7A45BDC7CA95F8" modified="2015-07-22" version="1">MLIAGFPAGAWGTNCYLLAPAAGEECVIVDPGHRAADGVAETVAKHRLKPVAVVLTHGHLDHVASVIPVCGAHDVPAWIHPADRYMLADPEKALGMAVGAPLLGDLTVGEPDDVAELADGAELELAGLSLTVAHAPGHTKGSVTFRLPEQRDVPQVLFSGDLLFAGSIGRTDLPGGDGAEILESLARVCLPLDDSTVVLPGHGPQTTIGRERAGNPFLRELAAGRAGGPAAPLRHRRGM</sequence>
</entry>
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    <accession>A0A0F7N1S5</accession>
    <name>A0A0F7N1S5_9ACTN</name>
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        <submittedName>
            <fullName evidence="3">MarR family transcriptional regulator</fullName>
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    </gene>
    <organism evidence="3 4">
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="149"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH82545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="306" mass="34435" checksum="8A814B0DF1A7934E" modified="2015-07-22" version="1">MTVEDIRSFNRFYTNLIGALDYSRQLHTPYTLTEARVLYELSYARQADAADLRGALTLDAGYLSRLLGKFEKDGLITRGPSAADARRQRVELTPRGREAAHLLEERSREQVGTLLAQVPLEQRARLAAAMSTVRELLSESAVPSPVEEAELREPGPGELGWIVKRHGELYAQEYGWDTDFEALVARIVADHAAQRDPSCERTWIADLGGRPVGTVMCVRDDAPETARLRLLLVDPEVRGHRLGARLVDECVRFAREAGYRELVLWTNSVLESARRLYERAGFELVAEKPHHSYGADLVGQDWRLTL</sequence>
</entry>
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    <accession>A0A0F7N1Y4</accession>
    <name>A0A0F7N1Y4_9ACTN</name>
    <protein>
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        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">AA958_06920</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_06920"/>
    <dbReference type="EnsemblBacteria" id="AKH81991">
        <property type="protein sequence ID" value="AKH81991"/>
        <property type="gene ID" value="AA958_06920"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_06920"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1446"/>
    <dbReference type="OrthoDB" id="1936227at2"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH81991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="183" mass="20955" checksum="0C068D9D62AB83DE" modified="2015-07-22" version="1">MSEVESKHVRPAEAPKGRPTPKRSESQAQRRAMAKTPVTRKEASKRARETRRADMARQREALASGNEKYLPARDKGPVRKFVRDYVDSRWCVAEFFLPLAIVILLLSITPSAGLKNISLLLWLFVIVLIVFDSIAISVQVKKQLKARFPDESHRGARAYALMRTLQLRRMRLPKPQVKRGERP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N205</accession>
    <name>A0A0F7N205_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peripla_BP_6 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_00420</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH80882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_00420"/>
    <dbReference type="EnsemblBacteria" id="AKH80882">
        <property type="protein sequence ID" value="AKH80882"/>
        <property type="gene ID" value="AA958_00420"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_00420"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.100"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028081">
        <property type="entry name" value="Leu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13458">
        <property type="entry name" value="Peripla_BP_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519044" description="Peripla_BP_6 domain-containing protein" evidence="2">
        <location>
            <begin position="32"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_6" evidence="3">
        <location>
            <begin position="39"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="373"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH80882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="404" mass="42149" checksum="A700C3F56CE7616B" modified="2015-07-22" version="1">MNRSFPAAVAVTTAVSLVVLGCSPKASQSAAAPGVDGDTISLGVLTDLSGAFVAGGTDTLRGLQLQWDEINDRGGVCGRKVELAVEDHGYNTETAVSQYTGMEPDVLAFQMLLGSPMVSALTPRIGKDEVLTIPSSFAANLLESPLIALTGTTYRQETANAVHWLKETGALEGGKKIGHIYLQGEYGEDALAGTEDAAAELGLGKVAGQVVKASDKDLTAQVSALRSSGVDYVMLTTAPTQTASAVSVAKALGYDADFIGSTFTYVPSLLDGSAKGPLTEHFYQTSALAPLSSSQEGPARILEAFKDRWPDQIPNPPVVHGAGAAEVMHKVLKAACAEGDLTRENVEKTYRDLAGVDTGGLLPALDFTARGEPPTHTSYLLRPDPDEPGGLKLLTELRPGPGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N275</accession>
    <name>A0A0F7N275_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AAA ATPase forming ring-shaped complexes</fullName>
            <shortName evidence="2">ARC</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">arc</name>
        <name evidence="6" type="ORF">AA958_04015</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homohexamer. Assembles into a hexameric ring structure.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014848.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_04015"/>
    <dbReference type="EnsemblBacteria" id="AKH81493">
        <property type="protein sequence ID" value="AKH81493"/>
        <property type="gene ID" value="AA958_04015"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_04015"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.842"/>
    <dbReference type="OrthoDB" id="1115436at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019941">
        <property type="term" value="P:modification-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02112">
        <property type="entry name" value="ARC_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041626">
        <property type="entry name" value="Prot_ATP_ID_OB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022482">
        <property type="entry name" value="Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17758">
        <property type="entry name" value="Prot_ATP_OB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03689">
        <property type="entry name" value="pup_AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="5">
        <location>
            <begin position="265"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="60"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="276"/>
            <end position="281"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH81493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="588" mass="65204" checksum="24308E3BBB32CF6F" modified="2015-07-22" version="1">MAAHDDDTNRGIRPGRGSEDPAGQVAYLEQEIAVLRRKLADSPRHTRILEERIVELQTNLAGVSAQNERLASTLREARDQIVALKEEVDRLAQPPAGFGVFLEANDDGTADIFTGGRKLRVNVSPSVELDELRRGQELMLNEALNVVEAMAFERSGDIVTLKEILEDGERALVMGHTDEEKVVRLAEPLLHTTIRAGDALLLEPRSGYVYEVIPKSEVEELVLEEVPDIDYTKIGGLGNQIELIRDAVELPYLYPDLFKEHELRPPKGVLLYGPPGCGKTLIAKAVANSLAKKVAEHTGRPAGKSYFLNIKGPELLNKYVGETERHIRLVFQRAREKASEGTPVIVFFDEMDSLFRTRGSGVSSDVENTIVPQLLSEIDGVEGLENVIVIGASNREDMIDPAILRPGRLDVKIKIERPDAEAAKDIFSKYLTRTLPLHAEDMSEHGDSAEATVDAMIQSVVEQMYAESEENRFLEVTYANGDKEVLYFKDFNSGAMIENIVDRAKKMAIKAFLDHNQKGLRVSHLLAACVDEFKENEDLPNTTNPDDWARISGKKGERIVFIRTLVTGKQGADTGRSIDTVANTGQYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2A6</accession>
    <name>A0A0F7N2A6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_07730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015491.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_07730"/>
    <dbReference type="EnsemblBacteria" id="AKH82141">
        <property type="protein sequence ID" value="AKH82141"/>
        <property type="gene ID" value="AA958_07730"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_07730"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1625"/>
    <dbReference type="OrthoDB" id="1948290at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH82141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="226" mass="23424" checksum="C8C5EB09B4B16350" modified="2015-07-22" version="1">MELPPPAPALLSPPAPAVLAAFEAAPGFMPRDEGLALHAAAAEAAGLGLPLLEVGTYCGRSTILLAAAARAAARPGVVAVTVDHHRGSEEQQPGWEYHDPALVDPATGLMDTLPAFRRTLYAAGLEDHVVAVVGRSPQIAALWNRPLGLAFVDGGHTDEHATADYEGWAPHVAPGGLLAVHDVFADPAEGGQAPYRIYRRALDSGAFTESAAQGSLKVLRRTGTGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2E3</accession>
    <name>A0A0F7N2E3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_04370</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014904.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH81549">
        <property type="protein sequence ID" value="AKH81549"/>
        <property type="gene ID" value="AA958_04370"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_04370"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.918"/>
    <dbReference type="OrthoDB" id="1857862at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014322">
        <property type="entry name" value="RNA_pol_sigma-B/F/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02980">
        <property type="entry name" value="SigBFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="42"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4" evidence="7">
        <location>
            <begin position="209"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH81549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="281" mass="31255" checksum="50B7EA4BEDEB07FC" modified="2015-07-22" version="1">MAHVRTRRKHPHHDAPDTSAQFRRLAGMPEGPDKKALRQEVVRAWMPMAARLARQFRNRGEALEDLEQVAHLGLVKAVRRYDAGRSSAFESFAVPTIVGELKRHFRDHMWGVHVPRRVQELRNRVRSAGLALAVTADDRFPAIADIAEAAELTEEEVRTGLEAWESYATLSLDAALPGAGDGYSLLDTFGSTEPGFDQAVDREAVRPHLSRLPEREREILYLRFFCDMTQRGIAEHLGISQMHVSRLISHSCARVCERVEADQAAAGRTPAPDPLGSATAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2E6</accession>
    <name>A0A0F7N2E6_9ACTN</name>
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    </gene>
    <organism evidence="2 3">
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        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
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    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_04390"/>
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    <dbReference type="Proteomes" id="UP000034283">
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="87" mass="9468" checksum="C15031AE7D002146" modified="2015-07-22" version="1">MVLLVTACGGAGDDGPGAEEDSRPSSPAAQDEDRAEPLSKQGIRQALPRKSDFGRDWDVGPVETEKEYLDDGGKAPPSDRWWHLMMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2T1</accession>
    <name>A0A0F7N2T1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycerophosphodiester phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_02055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_02055"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.443"/>
    <dbReference type="Proteomes" id="UP000034283">
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GP-PDE" evidence="1">
        <location>
            <begin position="1"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="216" mass="23570" checksum="47B8829B3A5807AD" modified="2015-07-22" version="1">MGVEPENTIRSFVRADREGMDAIELDVHLSKDGHLVVMHDPDVDRTTDGEGPIADFTLAELRELDAGQGERVPTFDEVVEAVKGRLQVEIKDVAAAKALAGAMTAHDLAGRVEVLSFHDEALAEMRQLLPDVPRVLVASHYGVGVVDRAREVGAVMLSLNIRRLTLELADRAHDAGLQVIAWTVNTPEELKLARGLRLQGVVTDFPGMKHSVRFTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-12-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N308</accession>
    <name>A0A0F7N308_9ACTN</name>
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        <submittedName>
            <fullName evidence="9">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AA958_09235</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP011492">
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    </dbReference>
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH82381">
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        <property type="gene ID" value="AA958_09235"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_09235"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1948"/>
    <dbReference type="OrthoDB" id="149255at2"/>
    <dbReference type="Proteomes" id="UP000034283">
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
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    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="161"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="370"/>
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    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="513"/>
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    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="541"/>
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        </location>
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            <end position="646"/>
        </location>
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        </location>
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            <end position="688"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH82381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="688" mass="71182" checksum="FB77BF0A8F793BFA" modified="2015-07-22" version="1">MLGLWVAILALAMPFGSKLGDVSRDRAVDYLPGSADSTQVSQIAEEMPGGDTLAGILVYQRDGGITAADRELAAGHAGAVADRFELAKDGTPQAVPAEDGSTLMLPFSVVGLPDEDAQTAAVEEIREEIVADPPEGLSVELGGPAGIQADAEAVYEEVDGTLMYATAGIVTILLILTYRSPFLWLLPLVCVGVASMSAMALVYGLVQAFDLTVNSMSSAVMTVLIFGAGTDYALLLVARYREELRRTTDAQEAMLTAVRNCGPAILASSGTVAAGLICLLAADLNSSAGLGPVGAVGVVCALAVMTTLLPALMVLFGRRIFWPLVPAYGSEPKRRGFFDRMGSSVGRRPAAILLGGVVLLGALALGAFNLPGNLKQEDAFTDKPESITAMEKLKDAYPEQSAQAIVVVADAARADAALSAAQGVEGVVSAETARSGNGYTEITVYAADPPQSAGEDRTIADLRSELGALDGADALVGGPSAEALDLAEANSGDRKLVIPLTLAAVLVILIVLLRSLVAPLVLTVAVVASWGAAMGIGGLIFEPVMGYPGIGGELALLTFVFGVALGVDYGIFLLHRMREEATNGADTRTAALTALRRTGGVIASAGLVLAATFAALATMPMVMMFELGFVVAVGVLLDTFLVRTYLVTSASWLLGKKIWWPGPLSKREEAPPSAPGEQREPEPAGAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3I7</accession>
    <name>A0A0F7N3I7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_10640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
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        <lineage>
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            <taxon>Streptomycetaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_10640"/>
    <dbReference type="EnsemblBacteria" id="AKH82606">
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        <property type="gene ID" value="AA958_10640"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_10640"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2238"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF12277">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="114" mass="12270" checksum="94C0558BC711BCF7" modified="2015-07-22" version="1">MSDGRTPAQIEADIARRRQDLAATLDEISLRVSPKNLVDEAKARTKGAVDRTAGQAFVVANRAVDSARGVLVSPDGGPRMERIVPVAVTLVAVAGLLALGSRRPGKYRGRRRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N446</accession>
    <name>A0A0F7N446_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_04745</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="451" mass="47516" checksum="CDABA847CFE8506B" modified="2015-07-22" version="1">MAERVAGWLRTALRVLRADLWTTAVSPPPRTEPAAAAERSRLREWLPALVVPVVLGLAALQIAATNQYAFGYGMGMRIAALLTALQTAAFLIALVRPVLAWWIMTVAMVVVARYAIVSSGSDAGAMFPWTGTGLVLQATVLFAVALRCRPRIAVETLVISVLVGLGYGFLGDTEGVPFAVLVLTLPVGAGVALRGRRVARTELAAQEELTAEERARRVLLQERTRIARELHDVVAHHMSVISIQAQVAPHLVRDPPAELKENLAGIRASAVEALTELRRVLGVLRADDPSPGAAALRPHDVRHAPQPTLDRLGELAAAVRRAGVDAGIRTTGEPYPLPPGIELSAYRIVQEALSNVARHAPGARALVEIGYHPAGLTVRVTNTAPERAAPPWAGAGHGLLGMRERAAMLGGELATGTTPDGGYEVTAILPAAAPVPAAPASPAIPDGEDTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
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            <authorList>
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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            <end position="160"/>
        </location>
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        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH82204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="161" mass="17361" checksum="59C670D139D2817E" modified="2015-07-22" version="1">MALDGIEALAPGAGAPDFALRNEHGETVRLSDYRGEKAVVLLFFPYAFTGVCTGELCALRDRLPAFVNDEVQLLAVSCDTPFALRVFADREGFGYPLLSDFWPHGATARAYGVFDGEKGCAVRGTFIIDTAGTVRWTVVNDLPDARDLDEYVAALKALAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4C0</accession>
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        <recommendedName>
            <fullName evidence="6">Phosphate transporter</fullName>
        </recommendedName>
    </protein>
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    </gene>
    <organism evidence="8 9">
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        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.</text>
    </comment>
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        <property type="protein sequence ID" value="AKH81707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_05275"/>
    <dbReference type="EnsemblBacteria" id="AKH81707">
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        <property type="gene ID" value="AA958_05275"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_05275"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1107"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Phos_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101">
        <property type="entry name" value="PTHR11101"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PHO4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
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        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="241"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        </location>
    </feature>
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            <begin position="362"/>
            <end position="405"/>
        </location>
    </feature>
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        <source>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH81707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="405" mass="40743" checksum="FD4EDC95213E6345" modified="2015-07-22" version="1">MEHLTLIIGVVVVTALVFDFTNGFHDTANAMATTISTGALKPKTAVAMSAVLNLIGAFLSVEVAKTISGGIIDEGSGIQPEVIFAGLVGAIVWNLLTWLAGLPSSSSHALFGGLIGATLVSVGWNGVHMDAIVMKVLIPAIAAPLVAGVAAAAATRLTYRLAKRRSADQTARGYRAGQITSGALVSLAHGTNDAQKTMGVITLALITGGSLAPNSDPPTWVIVSAALAIALGTYLGGWRIIRTMGKGLTDIQPPQGFSAQTSSATVILASSHLGFALSTTQVCSGAIMGSGVGKKGGVVRWSTAGRMVAAWGLTLPAAGLIAGAAAFLADRGDWGVVTVAILGVAACATIWAASRRDRVDHSNVNDVDPVTGEPVTAGDGADGAVEPVSIPAPRTASGPASQATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4E9</accession>
    <name>A0A0F7N4E9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_08475</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015611.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH82263">
        <property type="protein sequence ID" value="AKH82263"/>
        <property type="gene ID" value="AA958_08475"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_08475"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1789"/>
    <dbReference type="OrthoDB" id="1854263at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="101"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="123"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH82263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="148" mass="15636" checksum="44DF683A4D2F8226" modified="2015-07-22" version="1">MTSPTASSHGTTSPSPTPPHRGGSPWATGGTVFAGVMMLVYGVLAVFQGIAGIAHDDVYARQGDYVFKFDLTTWGWIHLILGVVVAAAGLGILMGNEWARLLGVALAALAVIANFAWLPYLPVWAIVNIAIGVFVIWALCTDRSRSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-12-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4G5</accession>
    <name>A0A0F7N4G5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ion_trans_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_08480</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH82264">
        <property type="protein sequence ID" value="AKH82264"/>
        <property type="gene ID" value="AA958_08480"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_08480"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1790"/>
    <dbReference type="OrthoDB" id="1991946at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Ion_trans_2" evidence="3">
        <location>
            <begin position="103"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH82264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="215" mass="23420" checksum="BA406A14A5EEF316" modified="2015-07-22" version="1">MKSPRDDDEADVRGGHRDDGPERRRDPLLAWLREVVPVALMVVAYFLLPLHLLGGERPELSWTLFALALSTVTLLLLREIRAVLMEVPHARPGVTIPLLMIASLLVFSAAYNGIARHSAEFHGLRTRVDALYFTVATVATVGYGDITARGQTARILVMGQITYSFVFLTAAATALSRRLRRSLGEGRTSGGGRHGRGRRRGTGRRRGGGPSAGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4I4</accession>
    <name>A0A0F7N4I4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aspartate--tRNA ligase</fullName>
            <ecNumber evidence="7">6.1.1.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Aspartyl-tRNA synthetase</fullName>
            <shortName evidence="7">AspRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">aspS</name>
        <name evidence="9" type="ORF">AA958_16630</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + L-aspartate + tRNA(Asp) = AMP + diphosphate + L-aspartyl-tRNA(Asp)</text>
            <dbReference type="Rhea" id="RHEA:19649"/>
            <dbReference type="Rhea" id="RHEA-COMP:9660"/>
            <dbReference type="Rhea" id="RHEA-COMP:9678"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.12" evidence="7"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016870.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_16630"/>
    <dbReference type="EnsemblBacteria" id="AKH83565">
        <property type="protein sequence ID" value="AKH83565"/>
        <property type="gene ID" value="AA958_16630"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_16630"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3500"/>
    <dbReference type="OrthoDB" id="226836at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004815">
        <property type="term" value="F:aspartate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006422">
        <property type="term" value="P:aspartyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00044">
        <property type="entry name" value="Asp_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004524">
        <property type="entry name" value="Asp-tRNA-ligase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004115">
        <property type="entry name" value="GAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029351">
        <property type="entry name" value="GAD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594:SF5">
        <property type="entry name" value="PTHR22594:SF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02938">
        <property type="entry name" value="GAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55261">
        <property type="entry name" value="SSF55261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00459">
        <property type="entry name" value="aspS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="8">
        <location>
            <begin position="144"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Aspartate" evidence="7">
        <location>
            <begin position="199"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="221"/>
            <end position="223"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="446"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="480"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="487"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="532"/>
            <end position="535"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH83565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="587" mass="65191" checksum="7DDC4F8F4AA38CE2" modified="2015-07-22" version="1">MHRYRSHTCGELRASDVGSDVRLSGWLHNRRDLGGILFIDLRDHYGIVQLVARPGTPGNEALAHLTKETVVRIDGKVVSRGADNVNPELPTGEIEIEVGDVEVLGGAEQIPFTINAEDGVGEERRLEYRFLDLRRERMHRNIMLRTAVVTAIRQKMTALGFNELTTPILSATSPEGARDFLVPSRLHPGTFYALPQAPQQFKQLLMMAGFDRYFQIAPCFRDEDARADRSPGEFYQLDMEMSFVEQEDVFAVIEKVMTELFEEFGDGRHVTSPFPRVPYRDAMVKYGSDKPDLRAELELSDVTDVFAESGFQAFAGKHVRALPVPAVQDQPRKFFDALGDFAVEQGAKGLAWVRVGEGGALSGPIAKFLTEENVRVLTERLGLEAGHAVFFGAGETGEVSRIMGAVRVEAAKRAGHFAEGVFRFCWIVDFPMFEKNEDTGEIEFSHNPFSMPQGGMAALENKDPLDVLAFQYDIVCNGVELSSGAIRNHEPEVMFKAFGIAGYSKDEVEREFGGMLRALRFGAPPHGGIAPGIDRIVMLLADEPNIRETIAFPLNGNAQDLLMGAPSEVDEARLRELHIELRKPQPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4N0</accession>
    <name>A0A0F7N4N0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lactate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_08890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015671.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_08890"/>
    <dbReference type="EnsemblBacteria" id="AKH82324">
        <property type="protein sequence ID" value="AKH82324"/>
        <property type="gene ID" value="AA958_08890"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_08890"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1872"/>
    <dbReference type="OrthoDB" id="1374098at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1530.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043144">
        <property type="entry name" value="Mal/L-sulf/L-lact_DH-like_ah"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043143">
        <property type="entry name" value="Mal/L-sulf/L-lact_DH-like_NADP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036111">
        <property type="entry name" value="Mal/L-sulfo/L-lacto_DH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003767">
        <property type="entry name" value="Malate/L-lactate_DH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11091">
        <property type="entry name" value="PTHR11091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02615">
        <property type="entry name" value="Ldh_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89733">
        <property type="entry name" value="SSF89733"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="368" mass="38049" checksum="37CC48795A7C7D5B" modified="2015-07-22" version="1">MTLLPYHQLTDFTTEVFQAHGVPEDRARTAAEALVYGDLVGMRSHGLANLTRLYLPLFTSGRVAPAAEPEVLADRGATVLLDSRKGLGLWAAAEAMDLAAERAGQYGIGMVSVRDATHLGCAGFHAARAVENGMIGLVASNCGRQRIARPPGGRVAMLGTNPLAAAAPAGPGQAPFVLDMSTTVAPTGKVREAARAGRSIPEGWLQDAEGRWVTDPHALDRGEGFPLFLGGQPETGGYKGYGLALLVEVLAALVPGAGLGPDPEAYSGTGGPSGRDDDIGFFVLAVAPAALRPEEDFTRQAAGLFAALTGSPTLPGTDKVVYPGCREADLKAAALAEGVPVADALLGELRSVADDLGLKLPEGDRNDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N522</accession>
    <name>A0A0F7N522_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_06450</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_06450"/>
    <dbReference type="EnsemblBacteria" id="AKH81907">
        <property type="protein sequence ID" value="AKH81907"/>
        <property type="gene ID" value="AA958_06450"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_06450"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1347"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519130" evidence="3">
        <location>
            <begin position="28"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="126"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="163"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH81907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="223" mass="22872" checksum="91C1126533E09F50" modified="2015-07-22" version="1">MEHAAVTIRVMRAAVFTALCISLSAGAHVLLSANPLPLGMLAALSAGVFAVAFLLAGRRERGYWSIAALLVPLELAADTVFTTGQHTCYGQSGGPVAGSMRSLGLDLLCSGEFGTPLARMTARGEALAGTAASPWLLLGAHVGVGLVAAAWLRRGEAALAGLLRAAAAVAFRPLLLAVAIVTVAPVRSTGRPGRRPDRTRAGRPQPHLLHSVLRRGPPCPAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5B2</accession>
    <name>A0A0F7N5B2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Beta-glucosidase</fullName>
            <ecNumber evidence="3 11">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AA958_10470</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="3 11"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015921.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_10470"/>
    <dbReference type="EnsemblBacteria" id="AKH82579">
        <property type="protein sequence ID" value="AKH82579"/>
        <property type="gene ID" value="AA958_10470"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_10470"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2206"/>
    <dbReference type="OrthoDB" id="654705at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102483">
        <property type="term" value="F:scopolin beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018120">
        <property type="entry name" value="Glyco_hydro_1_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017736">
        <property type="entry name" value="Glyco_hydro_1_beta-glucosidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033132">
        <property type="entry name" value="Glyco_hydro_1_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="PTHR10353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00131">
        <property type="entry name" value="GLHYDRLASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03356">
        <property type="entry name" value="BGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00572">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00653">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="6 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="428"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8 10">
        <location>
            <position position="374"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="421"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR617736-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR617736-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AKH82579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="472" mass="51457" checksum="FED0AE7410F55BC9" modified="2015-07-22" version="1">MSDTTATFPEDFLWGTATAAYQIEGAAREHGRTPSIWDTFSHTPGKTAGGDTGDVAVDHYHRRTEDVELMAGLGIGAYRFSVSWPRVQPTGRGPAVQRGLDFYRQLADELLAAGIKPVLTLYHWDLPQELETAGGWPERDTAHRFADYARLVGEALGDRVELWTTLNEPWCSAFLGYAAGVHAPGRTDPVAALRAAHHLNLAHGLATDVLRTVLPARAQVSVSLNPAVVRPRTDSEADRDAARQVDALATRIFTGPMLDGAYPPDLLDDTARLTDWSFVRDGDLPLINRPLDSIGLNYYTPTVVSAVSGDARPERADGHGGGAQSPWPAADHIAFHQPPGERTAMGWTVDPTGLTELLLRFTADAPDLPLYITENGAAYDDKPEPDGSVHDPDRIAYLHGHIGAVHRAMAEGADVRGYFLWSLLDNFEWAYGYAKRFGAVHVDYATQRRTPKSSARWYADVIRTGALPAPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5K7</accession>
    <name>A0A0F7N5K7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SsrA-binding protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Small protein B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">smpB</name>
        <name evidence="5" type="ORF">AA958_11140</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="3">The tmRNA-SmpB complex associates with stalled 70S ribosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SmpB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016032.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_11140"/>
    <dbReference type="EnsemblBacteria" id="AKH82694">
        <property type="protein sequence ID" value="AKH82694"/>
        <property type="gene ID" value="AA958_11140"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_11140"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2347"/>
    <dbReference type="OrthoDB" id="1720952at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070929">
        <property type="term" value="P:trans-translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09294">
        <property type="entry name" value="SmpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00023">
        <property type="entry name" value="SmpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023620">
        <property type="entry name" value="SmpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000037">
        <property type="entry name" value="SsrA-bd_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020081">
        <property type="entry name" value="SsrA-bd_prot_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30308">
        <property type="entry name" value="PTHR30308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01668">
        <property type="entry name" value="SmpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74982">
        <property type="entry name" value="SSF74982"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00086">
        <property type="entry name" value="smpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01317">
        <property type="entry name" value="SSRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="133"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH82694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="159" mass="18128" checksum="D8E9AC137093E2D6" modified="2015-07-22" version="1">MGKDTGRKLIAQNKKARHDYLILDTYEAGLVLTGTEVKSLRQGRASLADGFAHLDGGEIWLHNVHIPEYSQGTWTNHTARRKRKLLLHRAEIDKLIGKTQETGLTIVPLALYFKDGRAKVEIALARGKREYDKRQALREKQDNREAQKAISAARRRFRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5M5</accession>
    <name>A0A0F7N5M5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_15180</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016650.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_15180"/>
    <dbReference type="EnsemblBacteria" id="AKH83336">
        <property type="protein sequence ID" value="AKH83336"/>
        <property type="gene ID" value="AA958_15180"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_15180"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3198"/>
    <dbReference type="OrthoDB" id="1108236at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="239"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="278"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="312"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="342"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="365"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="401"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="446"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="21"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH83336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="486" mass="50377" checksum="8E9272DA2FF3D43B" modified="2015-07-22" version="1">MSSSAHLSTTSTKWDARLWGILLTVSLVVGLDALDVSMVGVALPSIQADLGLSTSTLQWVVGGYVLTYGGLLLLGGRTADLLGRRRVFLVAVAVFAVTSLLGGLVDDGGLLIATRLLKGVSAAFTAPAALSIITTTFHEGPARNKALGIFAVFGASGYSAGLVFSGLLTEAGWRWTFFLPFPVAVIALIAAFRVLPKEGPQERNGGYDLPGAVTGVGAMLLLVYTVVEAPEVGWGAARTLLQFVAAAVLLAAFFIIEQRSKHPLIRLGILRSGPLARANLGAAVFFGGYLGFQFLVMQYLQAVLGWSAMETALGFLPAALIVAFGSPRMVPLIMRYGTGRTIAGGVLAHLLAYVLFLAIDRDAPYAVGTLPSMVLLGIGFTLAFASFNIQATAGIEDHEQGLAGGLLNTSLQVGGAIGLAIVTAVLTANAEGATGSGALLNGFDPALYVVAGMALVGLVIALTGLRGSRRADPKPVEDREFVYAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5P1</accession>
    <name>A0A0F7N5P1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoadenosine phosphosulfate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_18750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017197.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_18750"/>
    <dbReference type="EnsemblBacteria" id="AKH83900">
        <property type="protein sequence ID" value="AKH83900"/>
        <property type="gene ID" value="AA958_18750"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_18750"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3932"/>
    <dbReference type="OrthoDB" id="674332at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01713">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002500">
        <property type="entry name" value="PAPS_reduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01507">
        <property type="entry name" value="PAPS_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAPS_reduct" evidence="1">
        <location>
            <begin position="12"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="277" mass="32110" checksum="4C4862D0B0964194" modified="2015-07-22" version="1">MSDVADNQKVRHVLGISGGKDSSALAVYMRNRVPEMEYFFCDTGAELPETYEYLNRLEAALGKSIVRLNADRDFDHWMEVYQGTLPSPQMRWCTKNLKIKPLEDWVGDDKVISYVAIRADENRLGYVSTKPNIDAVFPFREDGIDKEGVMRILDEAGIGLPDYYEWRTRSGCYFCFFQRKHEWVGLKERHPDLFDRAVEYEEKVRYRHTAMKGRNYTWSQGESLPELLERREEIEAKHQAALDRAAKRTKPNRPLLEVLSDALDSDDDEAGCSVCHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5T1</accession>
    <name>A0A0F7N5T1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PKS_ER domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_15475</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016688.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_15475"/>
    <dbReference type="EnsemblBacteria" id="AKH83376">
        <property type="protein sequence ID" value="AKH83376"/>
        <property type="gene ID" value="AA958_15475"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_15475"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3256"/>
    <dbReference type="OrthoDB" id="969875at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="3">
        <location>
            <begin position="8"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH83376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="336" mass="34415" checksum="F35BA78938F7300D" modified="2015-07-22" version="1">MLTAVATAADAPLTLTEREVPEPGPGEVLVRVIACGVCHTDLDLLQGHWPLARFPVVPGHEITGEVAALGPGVSWPAVGTAVGAQFLGDSCRHCDYCVRGEQILCPAKRITGIVMDGGYTEYAVLKADFVTPLPEGLDPVGAAPLMCAGLTAHNSLRQAGTTASSRVAVIGTGGVGALAIRYAVAMGARVAALGRSPHGEAAARDLGAERYITTRDTDPAEALRAWDGGADVILNAAPSTAAATAAVEGLAPDGTLVLCGYDDTPLELPPGPMVLNRLHVMLNPSGSPHDARDTLAFSATHGIVPDYTPIGLEGANAALEAMARSTPPNRSVITFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6A3</accession>
    <name>A0A0F7N6A3_9ACTN</name>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_12255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="444103.AA958_12255"/>
    <dbReference type="EnsemblBacteria" id="AKH82879">
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        <property type="gene ID" value="AA958_12255"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_12255"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2577"/>
    <dbReference type="Proteomes" id="UP000034283">
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    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
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    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519826" evidence="1">
        <location>
            <begin position="28"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="298" mass="31426" checksum="66F1686C4B614CA4" modified="2015-07-22" version="1">MRRISRLRLAGPVLLAAGLLVSGPATAEPFAESAQSAAAGRSSGKTTAVPYDWRNARIDGGGFVPGIVFNRSEPGLAYARTDIGGAYRWRESDKTWTPLLDSVGWDDWGHTGVASIASDPVEPDRVYAAVGTYTNDCDPGNGAVYRSADRGATWQKSPLPFKLGGNMPGRGMGERLAVDPHDNDVLYLGAPSGHGLWRSTDAGATFARVSGVDEADTIGFGKAAPGATYQALYTSARIGGVRGIFRSTDAGATWERINDDAHQWGRTGAAITGDPRVFGRVYVSTNGRGVVYGDVSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6M0</accession>
    <name>A0A0F7N6M0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Heat shock protein hspR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_17605</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_17605"/>
    <dbReference type="EnsemblBacteria" id="AKH83721">
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        <property type="gene ID" value="AA958_17605"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_17605"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3706"/>
    <dbReference type="OrthoDB" id="1661714at2"/>
    <dbReference type="Proteomes" id="UP000034283">
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="HTH merR-type" evidence="2">
        <location>
            <begin position="25"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="91"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH83721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="156" mass="17191" checksum="DABAD0211DA491B2" modified="2015-07-22" version="1">MNGRNGGRGAPRGRNPYELTEETPVYVISVAAELSGLHPQTLRQYDRLGLVSPDRTAGRGRRYSARDIALLRQVQTLSQDEGINLAGIKRIIELETQVAALQAKVAELTDALDGAASAMAQREAQVHASYRRDLVPYQQVQQTSALVVWKPKKKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6W3</accession>
    <name>A0A0F7N6W3_9ACTN</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="2 3">
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        <lineage>
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            <taxon>Actinobacteria</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AKH83826">
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        <property type="gene ID" value="AA958_18240"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_18240"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3835"/>
    <dbReference type="OrthoDB" id="1884920at2"/>
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    </dbReference>
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        <location>
            <begin position="142"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="268" mass="28416" checksum="C1BE8B51E9D833B3" modified="2015-07-22" version="1">MALSADELRVVRDALAIAIESSWGLPRPARGDGTEPAAAPAVPRGAVVRDCTELAAALDEAAAEADRMRLFRNADLARYRAALPGSASGYAELLHDALATGYAPGQADIAALRVLCDEPADSGVAERRRRLLRRCEALTAAQVPPRRRPEEPAPQVPAAAVTTAPAATSAPQSPPVPSPGLPRPALRALPGGRARRAARGSEESEPAPDRRPGKPGEQPQRPPRENPPDRQPASPHRPVPTPAEVFPPRRRPARPPEHLLRPHAARTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6Y4</accession>
    <name>A0A0F7N6Y4_9ACTN</name>
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            <fullName evidence="1">3-oxoacyl-ACP reductase</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="1 2">
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        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
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            <taxon>Actinobacteria</taxon>
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        </lineage>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_13905"/>
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        <property type="gene ID" value="AA958_13905"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_13905"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2927"/>
    <dbReference type="Proteomes" id="UP000034283">
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH83148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="247" mass="25219" checksum="5C1E6BBE07067590" modified="2015-07-22" version="1">MTRTVPTPQAPRTVLVTGGTSGIGRAIAARFAADQDRVFLTGRRPGTVEQAAEELGVHGVTCDATDPGQVAALAAGFGELDVLVNAAGGLPQAAPEDVPALEAVLAQWHSSLAQNLLGAVLTTTAVRDKLTSGSSVISIGSIGAERRGGSYGAAKAALAAWNAALSGELGPHGVTSNVISAGYIAGTNFFQGQMTDERHDALVQETHDKRPGTVEDIAETAYFLASPGARHLTGQTIHVNGGAFTTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6Z5</accession>
    <name>A0A0F7N6Z5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_13995</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016491.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_13995"/>
    <dbReference type="EnsemblBacteria" id="AKH83163">
        <property type="protein sequence ID" value="AKH83163"/>
        <property type="gene ID" value="AA958_13995"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_13995"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2945"/>
    <dbReference type="OrthoDB" id="1254678at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
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</entry>
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                <person name="Heide L."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
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    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_14550"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3063"/>
    <dbReference type="OrthoDB" id="1567374at2"/>
    <dbReference type="Proteomes" id="UP000034283">
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    </dbReference>
    <dbReference type="GO" id="GO:0016021">
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        <property type="project" value="UniProtKB-KW"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="179" mass="19910" checksum="FA3B4B2A2C65A042" modified="2015-07-22" version="1">MAVAAIEDVTESRLLLAEYDRIKEEQKTRIGFRDNLLYFTLAASTAVLAITVQSRQAQLLLAIPVICLILGWTYLVNDEKVSAVGCYIRDQLGPRLAELSGAHGAVFGWEIYHRAGASRTTRKRLQTAVDLFTYLGLPIICLTAFWCSPVVQPLLVIVSIAQTLALAVLGWQFLRFAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7N5</accession>
    <name>A0A0F7N7N5_9ACTN</name>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_15615</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
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            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
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    <reference evidence="1 2" key="1">
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
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    <dbReference type="STRING" id="444103.AA958_15615"/>
    <dbReference type="EnsemblBacteria" id="AKH83399">
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        <property type="gene ID" value="AA958_15615"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_15615"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3289"/>
    <dbReference type="OrthoDB" id="675981at2"/>
    <dbReference type="Proteomes" id="UP000034283">
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH83399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="78" mass="8491" checksum="03B67682B5B1D50E" modified="2015-07-22" version="1">MRAFPVCSLAVPAGEGRQCAASLLIPQIEPHTTPDVLDDARTLGEEDFMAGATEDRYPTSSSWRKEWTAEAVTVPVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7S6</accession>
    <name>A0A0F7N7S6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA nucleotidyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_16125</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
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            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
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    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_16125"/>
    <dbReference type="EnsemblBacteria" id="AKH83483">
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        <property type="gene ID" value="AA958_16125"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_16125"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3398"/>
    <dbReference type="OrthoDB" id="2018439at2"/>
    <dbReference type="Proteomes" id="UP000034283">
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProt"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01743">
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
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        <location>
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            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH83483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="486" mass="54402" checksum="4074C6621601C8FF" modified="2015-07-22" version="1">MPNAREDHRTQQATLSRAQRSAVSELLRVSPVADDLAHRFQDAGARLALVGGSVRDALLGRLGNDLDFTTDARPERVLDIVRPWADAVWEVGIAFGTVGCRKGELQIEITTYRSEAYDRTSRKPEVSYGDSIEEDLVRRDFTVNAMAVALPEKEFVDPHGGLDDLAARVLRTPGTPEESFGDDPLRMMRAARFAAQLGFEVAPEVVAAMTDMAARIEIVSAERVRDELNKLLLAPRPRLGLHLLVDTGLAGHVLPELPALRLERDEHHRHKDVYEHSLIVLEQAIALEESGPDLVLRLAALLHDIGKPRTRRFEKDGRVSFHHHEVVGAKMTKARMTKLKYPNDQIKDVSRLVELHLRFHGYGTGEWTDSAVRRYVRDAGPLLERLHKLTRSDCTTRNKRKALALQRAYDGLEERIARLQAQEELDAIRPDLDGNEIMKILGIGPGPAVGGAYRHMLELRLEHGPMGHEAAVEALRAWWAEQNPPA</sequence>
</entry>
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    <accession>A0A0F7N7X1</accession>
    <name>A0A0F7N7X1_9ACTN</name>
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    </protein>
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    <organism evidence="3 4">
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        <lineage>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AKH83528">
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        <property type="gene ID" value="AA958_16415"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_16415"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3455"/>
    <dbReference type="OrthoDB" id="1808992at2"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="54"/>
            <end position="78"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH83528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="261" mass="28941" checksum="C95C8E95FED6F48C" modified="2015-07-22" version="1">MESRQPDESRAGIPDGGGVTGAEAAAQAEPAEGGAAASPRPVLGVAGLSPVSRIIVALAIAVLVGVVTVHLGAGFLHVAPANTLSKKHDETIDRIVFPEFEQNWRLFAPNPLQTNIHVEVRAQLRMPGGDTEETGWVDLTAMDHENIRGNPAPSHTVQNELRRGWDYWTDTHDEDNRAISDRADLAEDYVKRIVMRRLGPVLNEGRVEKIQLRQTSRRIAPPPWSSEQWDTAPVYRELPWWIVTGEDLMESDREVWEESAQ</sequence>
</entry>
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    <accession>A0A0F7N815</accession>
    <name>A0A0F7N815_9ACTN</name>
    <protein>
        <submittedName>
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        </submittedName>
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    <gene>
        <name evidence="1" type="ORF">AA958_12660</name>
    </gene>
    <organism evidence="1 2">
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        <lineage>
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            <taxon>Actinobacteria</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_12660"/>
    <dbReference type="EnsemblBacteria" id="AKH82937">
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        <property type="gene ID" value="AA958_12660"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_12660"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2661"/>
    <dbReference type="OrthoDB" id="1377545at2"/>
    <dbReference type="Proteomes" id="UP000034283">
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    </dbReference>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH82937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="337" mass="35329" checksum="1CE89D808D913C11" modified="2015-07-22" version="1">MTHTTTPQQRTGSGFGARSTTADVLRGVDLSGRLAVVTGGYVGLGLATTRAFVRAGARVVVPARRRDAAEQALGGLAGEGPGAAEVDEMDLADLDSVRGFADRFLASGRSLDLLVNNAGVMASPETRVGPAGWEGQFAVNHLGHYALANHLRPALVRDGGARVVALSSRGHHLSGIRWDDPQFRAEPYDKWLAYGQSKTANALFAVHLDALGRDAGVRAFSVHPGEILTELARHIPREEQIAQGWIDEDGKVSDAFKTAEQGAATQVWAATSPHLAGLGGVYCEDCDVAERAGAGGEGELRAGVRDYATDPDQAARLWALSAELTGVEAFGAASSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N853</accession>
    <name>A0A0F7N853_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AA958_17010</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
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        <property type="protein sequence ID" value="AKH83628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_17010"/>
    <dbReference type="EnsemblBacteria" id="AKH83628">
        <property type="protein sequence ID" value="AKH83628"/>
        <property type="gene ID" value="AA958_17010"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_17010"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3577"/>
    <dbReference type="OrthoDB" id="760677at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
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        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
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        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
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    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
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    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="7"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="123"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="227"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH83628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="398" mass="42893" checksum="7DBE87EA0BD937E6" modified="2015-07-22" version="1">MDGYFLTERHIRLREEVRAYAEREVRPRIAGMEESRSVQFELSRDIARQGWLGVTVEAEYGGMDLGHLAKTIVIEELSRVSAAMGAMVQASQLGVAKIVHFGSAVQKKTWLPLISAGVCMPTIAVTEPTSGSHVLGMSASAERVGDEYIVNGRKVFVGNSHVGDLHGVVVRTGPGSKGLSALLVEADRPGCTLGPHRPSMGLHGFSFGEVIFDNCRVPVSNLLGQEGDGLSVAYSSSILYGRPNLTAVALGIHQALVEETTAFAARQIRYGRPLAELGTVKQRLGEMQSRLMTARLAAYHATHLLDRGLPCDAELQNAKLVNVESALDSARTAMEVHGACGLYPEMSVERYLRDAYHVLPPAGTSDVQRLRLAEVALGADHEPWSTRLAPHAVASQAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8A9</accession>
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        </submittedName>
    </protein>
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    </gene>
    <organism evidence="2 3">
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        <lineage>
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            <taxon>Actinobacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_17420"/>
    <dbReference type="EnsemblBacteria" id="AKH83693">
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        <property type="gene ID" value="AA958_17420"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_17420"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3664"/>
    <dbReference type="Proteomes" id="UP000034283">
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="110" mass="11298" checksum="98C49E2388C7EAE9" modified="2015-07-22" version="1">MVLIVASGITFLAYALEQPRDVGTLQLGVAILGVVALNAAIGFAQEYSAERTAETLAATVPHTCRVLRGGERREVPARDLVPGDAVVLEAGDAVSAGPVPGGPQLRVHGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-12-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8C9</accession>
    <name>A0A0F7N8C9_9ACTN</name>
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        <submittedName>
            <fullName evidence="2">Sporulation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_17385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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    </dbReference>
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    </dbReference>
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        <property type="gene ID" value="AA958_17385"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_17385"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3656"/>
    <dbReference type="OrthoDB" id="1033384at2"/>
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    </dbReference>
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        <property type="entry name" value="Spore_0_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40053">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="257"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="321" mass="33125" checksum="D36B1D1FBF04F217" modified="2015-07-22" version="1">MVFKRLLGAIGVGAPSVDTVLEGGAVLPGGTLGGRVLLRGGSAAADIEQITLELVARVEAEGGDGEHEGTVSFGRFPVGGAFRLGEEEAHEVPFSLVLPWETPITELHGQSLGLPLGVRTELAVAGARDAGDLDPLAVRPLPVQEAVLEAFGQLGFAFTSADLELGHIPGTGQQLPFYQEIELAPGPQFAHAMQEVEVTFLASPGGMEVVLEADKRGGMFSAGHDALARFTVSHHDVAQADWTALVDSWVKQLAEHRGAPPGSYGHGGHHHGEDHGRRGPGMGTVAVAAAGGLAAGVVGGMVAAEVVDEIGDAFEAEDEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8K9</accession>
    <name>A0A0F7N8K9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_18025</name>
    </gene>
    <organism evidence="2 3">
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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    </dbReference>
    <dbReference type="RefSeq" id="WP_047017090.1">
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH83789">
        <property type="protein sequence ID" value="AKH83789"/>
        <property type="gene ID" value="AA958_18025"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_18025"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3791"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="71" mass="7101" checksum="F57AF11B5F162603" modified="2015-07-22" version="1">MLSDGPGDGPGDPQGGAGSDGPYGGGTHRTSTAERGAFAFARCTCGWTGPARRARSRARTDAADHLPDALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8Q7</accession>
    <name>A0A0F7N8Q7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Succinate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_22020</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017688.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_22020"/>
    <dbReference type="EnsemblBacteria" id="AKH84426">
        <property type="protein sequence ID" value="AKH84426"/>
        <property type="gene ID" value="AA958_22020"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_22020"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4638"/>
    <dbReference type="OrthoDB" id="1992496at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000701">
        <property type="entry name" value="SuccDH_FuR_B_TM-su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01127">
        <property type="entry name" value="Sdh_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81343">
        <property type="entry name" value="SSF81343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="131"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH84426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="160" mass="17733" checksum="FECA0977EBAEDA52" modified="2015-07-22" version="1">MTMATSDVELTGSSAAYSADNPAPLIEAPRARTPRSARSTSRTRTNFELYGWVFMRVSGVVLAVLVVGHLLIQLVLDGGVSKVSFAFVAGRWASPFWMAWDLVMLWLAMLHGGNGLRTVINDYAERDGTRFWLKMLLYAATVFTILLGTLVIFTFDPNIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N938</accession>
    <name>A0A0F7N938_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Transcriptional regulator WhiB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">whiB</name>
        <name evidence="14" type="ORF">AA958_22675</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="11">Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="11">The Fe-S cluster can be nitrosylated by nitric oxide (NO).</text>
    </comment>
    <comment type="PTM">
        <text evidence="11">Upon Fe-S cluster removal intramolecular disulfide bonds are formed.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the WhiB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018834542.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_22675"/>
    <dbReference type="EnsemblBacteria" id="AKH84541">
        <property type="protein sequence ID" value="AKH84541"/>
        <property type="gene ID" value="AA958_22675"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_22675"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4770"/>
    <dbReference type="OrthoDB" id="1975204at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035731">
        <property type="term" value="F:dinitrosyl-iron complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01479">
        <property type="entry name" value="WhiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034768">
        <property type="entry name" value="4FE4S_WBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003482">
        <property type="entry name" value="Whib"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38839">
        <property type="entry name" value="PTHR38839"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02467">
        <property type="entry name" value="Whib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51674">
        <property type="entry name" value="4FE4S_WBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 11" id="KW-0408">Iron</keyword>
    <keyword evidence="6 11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 11" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="4Fe-4S Wbl-type" evidence="13">
        <location>
            <begin position="33"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="16"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AKH84541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="121" mass="13642" checksum="0DE29DB425736526" modified="2015-07-22" version="1">MLQSHQQSLQEARVPIQRSGRREEGDPWHTEAVCRRDEAALFFAPSKEPTADRLSREAAAKRVCARCPVMVECREHALLLPEPYGVWGGLTAAERRVVQARRRRRETAEKLTAPRGIAQAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9F7</accession>
    <name>A0A0F7N9F7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Deaminase/reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_19920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017364.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_19920"/>
    <dbReference type="EnsemblBacteria" id="AKH84074">
        <property type="protein sequence ID" value="AKH84074"/>
        <property type="gene ID" value="AA958_19920"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_19920"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4197"/>
    <dbReference type="OrthoDB" id="1306955at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RibD_C" evidence="1">
        <location>
            <begin position="3"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="195" mass="20661" checksum="2C28CE206E5FF35C" modified="2015-07-22" version="1">MRKLVYYIAATLDGFIAGPDGADPTGPGGFWPLPADYVQYLAAHYPETLPFMAREALGVTAEGSSFDTVLEGRKSYEIGLAAGVPDAYPHLRHLVFSTTLGESPAAAVEVVAGDPVARVAELKQEDGKDIWLIGGGALAGALYGEIDRLIVKLAPVTTGAGIPLFGREAAFDPRVWKLTAHEAVESGALFLTYDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-12-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9S2</accession>
    <name>A0A0F7N9S2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GCN5 family acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_15790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016739.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH83427">
        <property type="protein sequence ID" value="AKH83427"/>
        <property type="gene ID" value="AA958_15790"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_15790"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3328"/>
    <dbReference type="OrthoDB" id="1538300at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="11"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="185" mass="20528" checksum="EA027DD49DC74591" modified="2015-07-22" version="1">MFAISLGDDGAELRPLEPWQAGEFLAHMDRGREFIGRHVGLPDATADLESTRAWLQSYADKAASDSGRLYGIWLDGLLVGGVLFRVFDARQRTCEAGCWLEPAAAGRGLVTRAARVIIDWAVHERGVERVEWLVSAENTPSIKVAQRLGMSREAVLRAKHPYRGVRQDTEVWSVLASEWGKGREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9T5</accession>
    <name>A0A0F7N9T5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_27315</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018560.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH85325">
        <property type="protein sequence ID" value="AKH85325"/>
        <property type="gene ID" value="AA958_27315"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_27315"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5756"/>
    <dbReference type="OrthoDB" id="1085574at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519881" evidence="2">
        <location>
            <begin position="32"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH85325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="331" mass="34666" checksum="F32BFA9A3B5A4CB0" modified="2015-07-22" version="1">MRKHSGSVAARAVAAAAALALTALAAGPVQAVQGGDTAEAAERGAPVVLPSLGPDLVAYYDFGHPVRGNPALERDRGRSGTDIELVNGGAAMRVPDSAFPGAGSALQTAQVSPATAGNDDWKAGVYRPGGVPSMRAFNGVQSATVMGWFKMTGDNPSPNSNTSDPDDRYGAIGLAGVLSGTSDGHGVRALLELIEVNGELRLVALGRRVDEGSSQTFAAAEDWRRLLPPDEWVFLAATFDYSDGTMALFRNGERLDGFSTNPGDPWQVGGPGEHRASPTDPAGIKIGGSFPQKTREANPCNCRMDSLMFLDRELTGSQVRAQYRLMVAPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9V5</accession>
    <name>A0A0F7N9V5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FAD_binding_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_24370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_24370"/>
    <dbReference type="EnsemblBacteria" id="AKH84826">
        <property type="protein sequence ID" value="AKH84826"/>
        <property type="gene ID" value="AA958_24370"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_24370"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5136"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="2"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="481" mass="51440" checksum="A33B07B595A1D0F7" modified="2015-07-22" version="1">MGAGPAGMVAGITLAGYGVDVLLVEKRPEASELSRAMLISTRTMELVRRWGLEAAVRAKASDVEAYTYVTETLAAGTGTEMPMAIPTRPEAALVSPTRPAWAPQDDLEPVLLAHLRTLPAAQVRLGCELTALFQDDDGIRATLLDHATGSSHVVEARYVIGGDGPYSTVREQLGIAMEGLDHLGGYESVQFRAELDGVIGDPDRKPAVYMITRPDAAGFLSRRGQGDRWSFARGRAPDQPGLADLDDAGLAALLARAAGVDTLRPRIERFSSFALAAMLADRYRERRGFVIGDAAHRMTPRGGTGMNTAIQDAFDLGWKLAWTLQGWARDDLLDTYETERRPVGRHNVDFSAAPPTEPATAAETLPWDLNGRLAHHWVPPADGARDEPVSTVDLIGDGLTLLTGPEGKRWTGAGAVGAGPVPLAVHTLDRATADALGLPPAGAMLVRPDCREIQRWPEYDEAAPPRVESLTPAAHALLAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NA13</accession>
    <name>A0A0F7NA13_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH arsR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_27605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018609.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_27605"/>
    <dbReference type="EnsemblBacteria" id="AKH85375">
        <property type="protein sequence ID" value="AKH85375"/>
        <property type="gene ID" value="AA958_27605"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_27605"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5817"/>
    <dbReference type="OrthoDB" id="1617768at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="248"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="334" mass="36489" checksum="4CBE58C507023C2B" modified="2015-07-22" version="1">MAGKLHVHFNDRDFRHVQLARTADPIWEAILGLHVAYTPAPRLPARLRPWHRRARHRLQEHDLRRTCRFVNGIAPADATYFPDFLTPAESEDGITAALRTLRATPATRLAREIRLAARHRPLPSWTRRLAAGDRTVLADLADALHHLHHHLVAPDWSEIEATVAADRARQLEALEAGLPAVLATLEPFTWTDPVLTAPYPVDSTLHLHGRGLRLIPSYFCHTTPIALADPGLPPVVVHPVRRHPAPPPANGPTPHRDTALAALLGTSRARVLAALTPTTVPATTGGIAARLGMPASSVSGHLTVLRRAGLAESERAGPHVVHRLTARGRHLLDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NA54</accession>
    <name>A0A0F7NA54_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Succinate--CoA ligase [ADP-forming] subunit beta</fullName>
            <ecNumber evidence="6">6.2.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Succinyl-CoA synthetase subunit beta</fullName>
            <shortName evidence="6">SCS-beta</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">sucC</name>
        <name evidence="9" type="ORF">AA958_21700</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + CoA + succinate = ADP + phosphate + succinyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:17661"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.2.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterotetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the succinate/malate CoA ligase beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.5" evidence="6"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017640.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_21700"/>
    <dbReference type="EnsemblBacteria" id="AKH84378">
        <property type="protein sequence ID" value="AKH84378"/>
        <property type="gene ID" value="AA958_21700"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_21700"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4571"/>
    <dbReference type="OrthoDB" id="316012at2"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00558">
        <property type="entry name" value="Succ_CoA_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013650">
        <property type="entry name" value="ATP-grasp_succ-CoA_synth-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="CoA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017866">
        <property type="entry name" value="Succ-CoA_synthase_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005809">
        <property type="entry name" value="Succ_CoA_synthase_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815">
        <property type="entry name" value="PTHR11815"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08442">
        <property type="entry name" value="ATP-grasp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001554">
        <property type="entry name" value="SucCS_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="SSF52210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01016">
        <property type="entry name" value="sucCoAbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01217">
        <property type="entry name" value="SUCCINYL_COA_LIG_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="ATP-grasp" evidence="8">
        <location>
            <begin position="9"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding; shared with subunit alpha" evidence="6">
        <location>
            <begin position="318"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="52"/>
            <end position="54"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit alpha</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH84378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="390" mass="40968" checksum="B1E5C6067808B6FA" modified="2015-07-22" version="1">MDLFEYQARDLFAKHGVPVLAGEVIDTPEAARQVTAELGGRAVVKAQVKTGGRGKAGGVKLASDPDDAVEKAGQILGMDIKGHTVHKVMLAQTADIADEYYVSYLLDRANRTFLAMASVEGGMDIEEVAATKPEALAKIPVDANEGVTEAKAREIVDAARFPAEIADQVVEVLQTLWTVFVREDALLVEVNPLVKTAEGRVLALDGKVSLDENAEFRQPDHVAFEDKAAANPLEAAAKAKGLNYVKLDGQVGIIGNGAGLVMSTLDVVAYAGEKHSGVKPANFLDIGGGASADVMANGLEIILGDPDVRSVFVNVFGGITACDAVANGIVQALELLKTKGEDVTKPLVVRLDGNNAELGRKILSDANHPLVEQVDTMDGAADRAAELAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NA60</accession>
    <name>A0A0F7NA60_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glucanase</fullName>
            <ecNumber evidence="9">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AA958_25040</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="9">Belongs to the glycosyl hydrolase family 6.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="9"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018182.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_25040"/>
    <dbReference type="EnsemblBacteria" id="AKH84931">
        <property type="protein sequence ID" value="AKH84931"/>
        <property type="gene ID" value="AA958_25040"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_25040"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5277"/>
    <dbReference type="OrthoDB" id="1331351at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016288">
        <property type="entry name" value="Beta_cellobiohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036434">
        <property type="entry name" value="Beta_cellobiohydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001524">
        <property type="entry name" value="Glyco_hydro_6_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34876">
        <property type="entry name" value="PTHR34876"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01341">
        <property type="entry name" value="Glyco_hydro_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001100">
        <property type="entry name" value="Beta_cellobiohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00733">
        <property type="entry name" value="GLHYDRLASE6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51989">
        <property type="entry name" value="SSF51989"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00655">
        <property type="entry name" value="GLYCOSYL_HYDROL_F6_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00656">
        <property type="entry name" value="GLYCOSYL_HYDROL_F6_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2 9" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="4 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005117491" description="Glucanase" evidence="9">
        <location>
            <begin position="22"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6 8">
        <location>
            <position position="159"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001100-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AKH84931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="335" mass="35244" checksum="A88EFC4E54BA397B" modified="2015-07-22" version="1">MSVRIRTLLSLLLLGVLLGCAPDGGDGDGDAARDGERARPATAAKTPFWVDPGSPAARQVQAYKQQGRAEDAALLERIASRPVAEWPAGHDPGGDVRTAVRGAEADGRTAVLVAYNIPHRDCGQHSAGGAADAAAYERWIGSFADGIGDAKALVILEPDAIPHVVDGCTPPELHEERYRLISGAIARLKQHPGVMVYLDAGNSSWIADPGKLAHALRQAGIGAADGFALNVSNFQRTGEQLAYGRRLSDHLDGAHFVVDTSRNGNGPLSGAPDKVWCNPPGRALGEPPTTRTGDERADAFLWVKRPGESDGPCRGGPEAGAWWPEYALGLARRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAE2</accession>
    <name>A0A0F7NAE2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">Uricase</fullName>
            <ecNumber evidence="5 7">1.7.3.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Urate oxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_28425</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 7">Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5 7">
            <text>H2O + O2 + urate = 5-hydroxyisourate + H2O2</text>
            <dbReference type="Rhea" id="RHEA:21368"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
            <dbReference type="EC" id="1.7.3.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Purine metabolism; urate degradation; (S)-allantoin from urate: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 7">Belongs to the uricase family.</text>
    </comment>
    <dbReference type="EC" id="1.7.3.3" evidence="5 7"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018749.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_28425"/>
    <dbReference type="EnsemblBacteria" id="AKH85515">
        <property type="protein sequence ID" value="AKH85515"/>
        <property type="gene ID" value="AA958_28425"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_28425"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5990"/>
    <dbReference type="OrthoDB" id="1150949at2"/>
    <dbReference type="UniPathway" id="UPA00394">
        <property type="reaction ID" value="UER00650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004846">
        <property type="term" value="F:urate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019628">
        <property type="term" value="P:urate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002042">
        <property type="entry name" value="Uricase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42874">
        <property type="entry name" value="PTHR42874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01014">
        <property type="entry name" value="Uricase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000241">
        <property type="entry name" value="Urate_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00093">
        <property type="entry name" value="URICASE"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03383">
        <property type="entry name" value="urate_oxi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 5 7" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="21"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR000241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000241-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH85515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="325" mass="36226" checksum="E561610BEAC90E9F" modified="2015-07-22" version="1">MADRPARAARPAVLGRNQYGKAETRVVKVTRDGDTHHVRDLNVSVALAGDMDEVHYSGTNTHVLPTDTTKNTVYAFAKRYGIESPEAFAVHLARHFTTTQEAIHRARIRVEEYAWERIDAPSPAGYALTGGGTPTRHSFVRRGRETRVAQVTYDGERFEVLGGLKDLVVMNTTASEFWGYAKDAYTTLQEDYDRILATEVSAWWRHRWTGAAGTAGAEPPAWDESYGQTAKHLVTAFADTYSLSLQQSLYAMGARVVEHRPEIEEIRFSLPNKHHFRVDLEPFGLKNDAADGAVYFAADRPYGLIEATVLRAGADARIPEDMTNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAG1</accession>
    <name>A0A0F7NAG1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Pyrimidine-nucleoside phosphorylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_22045</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017691.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_22045"/>
    <dbReference type="EnsemblBacteria" id="AKH84429">
        <property type="protein sequence ID" value="AKH84429"/>
        <property type="gene ID" value="AA958_22045"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_22045"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4644"/>
    <dbReference type="OrthoDB" id="1724909at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004645">
        <property type="term" value="F:1,4-alpha-oligoglucan phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016154">
        <property type="term" value="F:pyrimidine-nucleoside phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006206">
        <property type="term" value="P:pyrimidine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006213">
        <property type="term" value="P:pyrimidine nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1030.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000312">
        <property type="entry name" value="Glycosyl_Trfase_fam3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017459">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036320">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035902">
        <property type="entry name" value="Nuc_phospho_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036566">
        <property type="entry name" value="PYNP-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013102">
        <property type="entry name" value="PYNP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018090">
        <property type="entry name" value="Pyrmidine_PPas_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017872">
        <property type="entry name" value="Pyrmidine_PPase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000053">
        <property type="entry name" value="Thymidine/pyrmidine_PPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10515">
        <property type="entry name" value="PTHR10515"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02885">
        <property type="entry name" value="Glycos_trans_3N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00591">
        <property type="entry name" value="Glycos_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07831">
        <property type="entry name" value="PYNP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000478">
        <property type="entry name" value="TP_PyNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00941">
        <property type="entry name" value="PYNP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47648">
        <property type="entry name" value="SSF47648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52418">
        <property type="entry name" value="SSF52418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54680">
        <property type="entry name" value="SSF54680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02644">
        <property type="entry name" value="Y_phosphoryl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00647">
        <property type="entry name" value="THYMID_PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PYNP_C" evidence="5">
        <location>
            <begin position="334"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH84429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="425" mass="44125" checksum="AA1E020CF020411D" modified="2015-07-22" version="1">MDAISVIRAKRDRERLSDEQIDWVVAAYTRGEVADEQMSALAMAILLNGMDRDEIARWTAAMIASGERMDFTALPRPTADKHSTGGIGDKITLPLAPLVAACGAAVPQLSGRGLGHTGGTLDKLESVPGWRASLSNDEMMATLRDVGAVICAPGTGLAPADRKLYALRDVTGTVESIPLIASSIMSKKIAEGTGALVLDVKVGSGAFMKDLDRARELAATMVGLGNDHGLRTVALLTDMSTPLGLTAGNALEVRESLEVLAGGGPADVVELTLALAREMLTAAGLRDADPAAALADGSAMDVWRRMISAQGGDPSAPLPTARETHPVPAPSTGVLTRLDAYAVGLAAWRLGAGRARKEDPVQAAAGVELHAKPGTVVTAGQPLLTLHTDTPERIPDALAALESAYDVAPPGATVERSPLILDRLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBD7</accession>
    <name>A0A0F7NBD7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_24075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018031.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_24075"/>
    <dbReference type="EnsemblBacteria" id="AKH84779">
        <property type="protein sequence ID" value="AKH84779"/>
        <property type="gene ID" value="AA958_24075"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_24075"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5074"/>
    <dbReference type="OrthoDB" id="1984437at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041581">
        <property type="entry name" value="Glyoxalase_6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18029">
        <property type="entry name" value="Glyoxalase_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyoxalase_6" evidence="1">
        <location>
            <begin position="8"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Glyoxalase_6" evidence="1">
        <location>
            <begin position="136"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="246" mass="26488" checksum="239710790CA728E0" modified="2015-07-22" version="1">MPLRPVQVNIKAVDHPAVGRFWADALGWEVQASGATTYVAPAGGLRWPHPAVLGIDVVPVPEPKTAAKNRVHLDLATLSAAHQEELVERLRALGAAPVDVGQAEVPWTVLADPEGNEFCVLEPRDVYRDTGPVAAVVVDCADPRAMARFWGGATDWKVHEVSDEHGVLRAAAGTGPYLELLRVPNPKTAPDRVHLDLLPYPGDDKEAEVARLRALGARDLDVGQGDAPWTCLTDPEDHEFCVLALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBD8</accession>
    <name>A0A0F7NBD8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNA polymerase sigma 70</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_24095</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Interacts transiently with the RNA polymerase catalytic core formed by RpoA, RpoB, RpoC and RpoZ (2 alpha, 1 beta, 1 beta' and 1 omega subunit) to form the RNA polymerase holoenzyme that can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH84783">
        <property type="protein sequence ID" value="AKH84783"/>
        <property type="gene ID" value="AA958_24095"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_24095"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5078"/>
    <dbReference type="OrthoDB" id="1335404at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="21"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="7">
        <location>
            <begin position="116"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH84783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="320" mass="34818" checksum="B9B3305883AC3AC1" modified="2015-07-22" version="1">MERMDGTATDRFDTGRFEDGRARLVSLAYRMLGSVADAEDAVQDAYLRWQAADRRRIEVPEAWLTKVLTNLCIDRLRSARARRERSVGAWLPEPVLDGDPVLGPADTFEQRESVSLAVLTLMERLSPVQRAVYLLHVTFSYGHAEIAGILGISESASQQHLHRARRRVTATRHGGGEADRAAALRIAEEFFTAAASGRTERLVELLTDDATAISDGAGLTGTMLRYDTPQRIAAIARAGFAASPTKRRFAGGIPAVHSAHVNGGPAILFVVGGKVFGAVTFDLAGGRIALVRGIADPARLGRLNEAWRRYEPGPPVLARW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-08-12" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBM9</accession>
    <name>A0A0F7NBM9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_30865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AHA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019113.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH85885">
        <property type="protein sequence ID" value="AKH85885"/>
        <property type="gene ID" value="AA958_30865"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_30865"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6523"/>
    <dbReference type="OrthoDB" id="1914312at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013538">
        <property type="entry name" value="Activator_of_Hsp90_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08327">
        <property type="entry name" value="AHSA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="267" mass="27918" checksum="C449345E16474B28" modified="2015-07-22" version="1">MTDDDPTARLSSHEITVPGTPDEVWRAIATGPGHAAWLFPADIDPAAGGAMTVHREPYGETAHATVTDWDPPHRFGYEEPAGPDAPPLATEFLVEAAGGGSCVVRVVNGFRHDGEGWEDLVEGAGEGWRMSLTVLRAYLTHFAGRPAGSVGVLVGLGLPAAERPRAAAVLDRLLGVGAAPAGAAFRTPAGAPELTGTVEARSPGYVLLRAAEPYPALYAFSCFPMAPGAPLSVNLLARLYGAPPGAAAREEDRWRAWLTSARHAFGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NC26</accession>
    <name>A0A0F7NC26_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MDMPI_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_25275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018224.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_25275"/>
    <dbReference type="EnsemblBacteria" id="AKH84973">
        <property type="protein sequence ID" value="AKH84973"/>
        <property type="gene ID" value="AA958_25275"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_25275"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5327"/>
    <dbReference type="OrthoDB" id="1805421at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017517">
        <property type="entry name" value="CHP03083_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017520">
        <property type="entry name" value="CHP03086"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024344">
        <property type="entry name" value="MDMPI_metal-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11716">
        <property type="entry name" value="MDMPI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03083">
        <property type="entry name" value="TIGR03083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03086">
        <property type="entry name" value="TIGR03086"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MDMPI_N" evidence="1">
        <location>
            <begin position="11"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="190" mass="20308" checksum="44A3104BBE1865FE" modified="2015-07-22" version="1">MAENETLALHAAALDQFTRHVHQVGPDQWGAATPCTEWSVRDLVNHMTVEQLWVPPLLAGDRVEGVGDEYEGDQLGDDPVEVWDGASAEARAAFAEPLALSRTVHLSYGDSSAESYCTEMAVDAIVHSWDLARGIGADDVLPAELAEFALAQVEPQARMLAASGLFAAPVPVPPDADAQTRLLGLTGRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NC43</accession>
    <name>A0A0F7NC43_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_30055</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018989.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH85761">
        <property type="protein sequence ID" value="AKH85761"/>
        <property type="gene ID" value="AA958_30055"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_30055"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6346"/>
    <dbReference type="OrthoDB" id="2092236at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036737">
        <property type="entry name" value="OmpA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH85761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="329" mass="35056" checksum="BC86A56E00ED2EAB" modified="2015-07-22" version="1">MTSTEPARQPLPGSRPEPAGDTALRVELTVARAAAAARAGDLDAALRELARSDDPAVTGHREVADLRARIHAQRGDWDEAERCWRQLLDDHPDDRSATAGLDRIRRFRRTGPMAAFDRRRHRLLPAAAVALCAGAVTAAAWVLPGGPADGSGDRPSDVSAPVAGAEQQAEKDVRQDLTAERERAAAAAETRREKALDALADEVRTPGIRTVRHEDSVEVVFEQGLFSRAAELTDAGAADLARLGKALGRPGDMRIEVLGHIADVREAPPSGGSDTSVWRAMVAARALSDASGRPLTAFSIASAEQRDAPYETDAQNRTVTVVLTPRTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCD4</accession>
    <name>A0A0F7NCD4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AA958_21565</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017619.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH84357">
        <property type="protein sequence ID" value="AKH84357"/>
        <property type="gene ID" value="AA958_21565"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_21565"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4541"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="50"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH84357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="531" mass="56564" checksum="683F685D1503DCA6" modified="2015-07-22" version="1">MTDEGDKVGDEPTSYGLRPPQQNAGGIAQGPAATQFVGDPSVGRLIGGRYRLAARLGVGGMGTVWRAHDEVVDRDVAVKEPRLPADLDERTRQTAYERMQREARAAARIDHPSVVTVHDVVMEDGRPWIVMELVRGRSLGDQLTEGTLDPREVARIGVAVLGALTAAHEAGILHRDVKPDNVLLGRHDRVVLTDFGIAQIEGEQGLTETGAFVGSPEYIAPERVLGQRPGPESDLWSLGVVMYAAVEGMSPYRRQTAPATLQAVLSAEPAALARGSGALGTVVMQLLRKDPAARPAPDEVRRQLEAVARPAPAPTMIAPVGGGAGGGLGGKLAAALPKGRGGRLAVLGGAIAVVAALVLTLANPFGGGDGAPEGWKTYDETEQLKASLAVPEDYKRSVDEGTVTYTDPGGTPSLWLTRSSGNEDSALAEANQTLDCDKGENLECTELSSDVDGSVEEFEYRGKDAAVMVTTWTRDEGYETETEMRSREFFYVNDDNIGWHLTVEMPAAGEGKRDGDRVFEEVVDSLDIQDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-10-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCG7</accession>
    <name>A0A0F7NCG7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_32590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019402.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86175">
        <property type="protein sequence ID" value="AKH86175"/>
        <property type="gene ID" value="AA958_32590"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_32590"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6881"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH86175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="139" mass="15229" checksum="1621064A96EC6F25" modified="2015-07-22" version="1">MGGDRRAARGITRQSAHERYKAAVDEWQLSLVEPYEQAAPGYRPARIHEAALEPTRTGQQLDEWARAHVPAARDDEHPVTGHLPRLSTAEEMVQVLDESCGSCKARSVAASAFEAGGAPDRWALSDCPARVGAWRSGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCH3</accession>
    <name>A0A0F7NCH3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Polyribonucleotide nucleotidyltransferase</fullName>
            <ecNumber evidence="7">2.7.7.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Polynucleotide phosphorylase</fullName>
            <shortName evidence="7">PNPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">pnp</name>
        <name evidence="10" type="ORF">AA958_26395</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>phosphate + RNA(n+1) = a ribonucleoside 5'-diphosphate + RNA(n)</text>
            <dbReference type="Rhea" id="RHEA:22096"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the polyribonucleotide nucleotidyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.8" evidence="7"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018414.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_26395"/>
    <dbReference type="EnsemblBacteria" id="AKH85174">
        <property type="protein sequence ID" value="AKH85174"/>
        <property type="gene ID" value="AA958_26395"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_26395"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5557"/>
    <dbReference type="OrthoDB" id="122725at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004654">
        <property type="term" value="F:polyribonucleotide nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01595">
        <property type="entry name" value="PNPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014069">
        <property type="entry name" value="GPSI/PNP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012162">
        <property type="entry name" value="PNPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015848">
        <property type="entry name" value="PNPase_PH_RNA-bd_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036456">
        <property type="entry name" value="PNPase_PH_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11252">
        <property type="entry name" value="PTHR11252"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03726">
        <property type="entry name" value="PNPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005499">
        <property type="entry name" value="PNPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46915">
        <property type="entry name" value="SSF46915"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="SSF54791"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="SSF55666"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03591">
        <property type="entry name" value="polynuc_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02696">
        <property type="entry name" value="pppGpp_PNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="S1 motif" evidence="9">
        <location>
            <begin position="651"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="723"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="514"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="520"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AKH85174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="743" mass="80276" checksum="19F223B8CB018872" modified="2015-07-22" version="1">MENETHYSEAVIDNGSFGTRTIRFETGRLAKLAAGSAVAYLDDETMVLAATSASKQPKDQLDFFPLTVDVEERMYAIGKIPGSFFRREGRPSEDAILTCRLIDRPLRPSFKKGLRNEIQIVATIEALNPDHLYDVVAINAASASTQLAGLPFSGPIGGTRVALIRGQWVAFPTHAELEEAVFDMVVAGRVLDDGDVAIMMVEAEATDQTVELVKGGATAPTEEVVAAGLDAAKPFIKTLCKAQADLAAKAAKPTGEFPVFLDYQDDVLQALTQAVRDELAQALTISNKLEREAELDRVKDVAAEKLLPQFEGREKEISAAYRALTKELVRERVIREKVRIDGRGVTDIRPLAVEVEAIPRVHGSALFERGETQIMGVTTLNMLRMEQQLDTLNPVTRKRYMHNYIFPPYSTGETGRVGTPKRREIGHGALAERAIVPVLPSREDFPYAIRQVSEALGSNGSTSMGSVCASTMSLLNAGVPLKAPVAGIAMGLISKEIEGETRYVTLTDILGAEDAFGDMDFKVAGTKEFVTALQLDTKLDGIPASVLAAALKQARDARLHILDVMMEAIDRPDEMSPHAPRIITIKIPVDKIGEVIGPKGKMINQIQEDTGAEITIEDDGTIYIGAADGPAAEAARTTINGIANPTMPEVGERYLGTVVKTTSFGAFVSLLPGKDGLLHISQIRKLAGGKRVENVEDVLGVGQKVQVEIAEIDQRGKLSLIPVLEDEEKDGDDAGKSEDESAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCQ5</accession>
    <name>A0A0F7NCQ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminotransferase</fullName>
            <ecNumber evidence="2">2.6.1.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_22430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.6.1.2" evidence="2"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017757.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_22430"/>
    <dbReference type="EnsemblBacteria" id="AKH84497">
        <property type="protein sequence ID" value="AKH84497"/>
        <property type="gene ID" value="AA958_22430"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_22430"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4723"/>
    <dbReference type="OrthoDB" id="554560at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004021">
        <property type="term" value="F:L-alanine:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="1">
        <location>
            <begin position="34"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="403" mass="44513" checksum="6BA836AF567527A6" modified="2015-07-22" version="1">MQVIQSTKLANVCYDIRGPVLEEAMRREAAGHQILKLNIGNPAPFGFECPPEILEDLLRTAGSAHGYGDSKGILPARRAVMQHYQTKGIDLDVEDVFLGNGVSELIQMSMQALLNDGDEVLIPAPDYPLWTASVSLAGGTPVHYRCDEQADWMPDLDDIERRITDRTRALVVINPNNPTGAVYDAELMRGLTDIARRHGLVLCSDEIYDKILYDDATHAPTATYAPDLLVLTFNGLSKAYRVAGYRSGWLAVCGPKQDARSYLEGLTILANMRLCANVPAQHIVATALGGRQSINDLILPGGRLLVQRDTAYDLLTQIPGVTCVKPKGALYAFPRLDPKVHKIKDDARFVLDLLRAENILLVQGTGFNWPRPDHFRIVTLLEKDGLTDAITRIGTFLDGYRQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCV4</accession>
    <name>A0A0F7NCV4_9ACTN</name>
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        <submittedName>
            <fullName evidence="4">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_33420</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
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    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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        <property type="gene ID" value="AA958_33420"/>
    </dbReference>
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    <dbReference type="PATRIC" id="fig|444103.5.peg.7058"/>
    <dbReference type="OrthoDB" id="2047542at2"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
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        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
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        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="31"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH86315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="217" mass="22935" checksum="8F2AEBB0ABDFD787" modified="2015-07-22" version="1">MTQDDVTSRRRPAGAELPLAGGPPAERADAAQNRRRILAAAAAMVAERGPDALSMDEVAKAAGVGVGTVYRRFGDRAGLAYAVIDDREVQFQAAFLQGPPPLGPGASAPERIRAFLHALVDRTEDQLGLLLVAEMDSADARFTEGSYELYRQHLALLVGRIRPEADVRWLADALLAPLAANLYGYQRRTGGMSVARVKAGYDDLLAGLAADGGAAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7ND12</accession>
    <name>A0A0F7ND12_9ACTN</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_33590</name>
    </gene>
    <organism evidence="3 4">
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        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019567.1">
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86345">
        <property type="protein sequence ID" value="AKH86345"/>
        <property type="gene ID" value="AA958_33590"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_33590"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.7093"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH86345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="268" mass="26458" checksum="ACC95DCCCAA42C23" modified="2015-07-22" version="1">MAMMDCPACGRWHDAGGAPWCAAAGRPPGAPADGGPVPLQEPGPAVPGPDPRDLELFAEGRAAYPDTSPYAQVPADDGTVEHPVVPGRARHGRGRRRRPPRARLAALAAAGVAALSGGLVAANVLGGDGRPDADRADERPDALFGPLPTNSAGTPDAGTPTAASPPAARADAPDRAQRSRPSTAPPPAPTADPTTPGPSPGGSSTEPAGPSSTASSRARVSAPSGTPSGSPSSSPSGSPTPTPTGSEGEEGEEEHGRTDGQGDRHPNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7ND65</accession>
    <name>A0A0F7ND65_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_27330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH85328">
        <property type="protein sequence ID" value="AKH85328"/>
        <property type="gene ID" value="AA958_27330"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_27330"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5759"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519515" evidence="1">
        <location>
            <begin position="32"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="184" mass="20021" checksum="E79512A9B98F7ABB" modified="2015-07-22" version="1">MKWVKAGATVGAALALSIGGVTPVGAWSAQASTADALDELVAPQADEETRRIAASDPQAVQTMATLCGDGYNLVGAEQLPDDGWRLGTLFRYSKLTSGGNWRYCMLFDNNTGSTKYMRLRTCEYTLEDPECRTDQGDFSQYAGPVYTGLHWKYPQCSKVVAIMKNTKESEKALIDAVRTANTCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7ND77</accession>
    <name>A0A0F7ND77_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ABM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_32665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_32665"/>
    <dbReference type="EnsemblBacteria" id="AKH86186">
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        <property type="gene ID" value="AA958_32665"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_32665"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6900"/>
    <dbReference type="Proteomes" id="UP000034283">
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    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
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        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51725">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABM" evidence="1">
        <location>
            <begin position="11"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="112" mass="12641" checksum="EC1B11074BF630C5" modified="2015-07-22" version="1">MASISAASPLFTLVNVFPVHRHEQKQLCDRMAQVTEELIRHLPGFVSASFHLSHDGEHVVNYAQWQSEADFRSMHDDPRLAEYFAYCRSVSRPVPLSCDVVHSYDAGRPDGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDE3</accession>
    <name>A0A0F7NDE3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA polymerase III subunit epsilon</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_28035</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018678.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_28035"/>
    <dbReference type="EnsemblBacteria" id="AKH85444">
        <property type="protein sequence ID" value="AKH85444"/>
        <property type="gene ID" value="AA958_28035"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_28035"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5909"/>
    <dbReference type="OrthoDB" id="1985371at2"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Exonuclease_RNaseT/DNA_pol3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="2">
        <location>
            <begin position="7"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH85444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="249" mass="26431" checksum="CDEC65EEB3CE1DCF" modified="2015-07-22" version="1">MGWYGELLVGFDLETTGTDPGEARIVSAAVVEAVRGVPARRREWLADPGVPVPPETTAIHGITDERATAHGRPAAEVADEVADALAAHWTRGVPVVAYNATFDLTLLAAELRRHGLASMRERLGGGEEGPVIDPYAMDRTVDPFREGKRTLEAVCVEYGVVLGRAHDAAEDALAAVRLAVAIAERYGDVASAGAWDLHRGQAGWHAERAEGYRQWLARQTRDAATAPMPDAATAGPVPKRGYGPDGAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDG8</accession>
    <name>A0A0F7NDG8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">LuxR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_27845</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018647.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_27845"/>
    <dbReference type="EnsemblBacteria" id="AKH85413">
        <property type="protein sequence ID" value="AKH85413"/>
        <property type="gene ID" value="AA958_27845"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_27845"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5869"/>
    <dbReference type="OrthoDB" id="930905at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="5">
        <location>
            <begin position="20"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="4">
        <location>
            <begin position="162"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="141"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH85413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="230" mass="23727" checksum="7B1D688CD7C0DAAB" modified="2015-07-22" version="1">MSVLLEQPTSLVAYRPNKPTAMVVVADPRVRSTVTRHLWALGVRDVIEASSIAEARPRIANPRDICVADVHLPDGSGLTLLSEARSAGWPNGLALSAADDIGAVRNALAGGVRGYVVTGTRTGMGLPTRPNAAHIGAAAGRLHHRRPPGSPGAGGNSGPPGHPGGYRELSGREVEVLRLVAEGQSNKAIGVSMGLSALTVKSHLARIARKLGTGDRAGMVAVALRTGIIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDM2</accession>
    <name>A0A0F7NDM2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">6-phosphofructokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_07915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_07915"/>
    <dbReference type="EnsemblBacteria" id="AKH86600">
        <property type="protein sequence ID" value="AKH86600"/>
        <property type="gene ID" value="AA958_07915"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_07915"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1666"/>
    <dbReference type="OrthoDB" id="1832160at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HATPase_c" evidence="1">
        <location>
            <begin position="12"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="129" mass="13936" checksum="B598470CEF1C3CFE" modified="2015-07-22" version="1">MPLEPVHKRQFARDAGEVGRARDFVAAALGGIACAELLADIRLCTSELATNAVRYGPAGRDFLVRVVTLHDTVRVEVHDTGDGCPRTRAPRHDDDHGRGLLVVAALADEWGVAERSGPGKAVWAEFVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDW7</accession>
    <name>A0A0F7NDW7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">3-oxoadipate enol-lactonase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_29245</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018878.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_29245"/>
    <dbReference type="EnsemblBacteria" id="AKH85649">
        <property type="protein sequence ID" value="AKH85649"/>
        <property type="gene ID" value="AA958_29245"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_29245"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6165"/>
    <dbReference type="OrthoDB" id="1792151at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012788">
        <property type="entry name" value="Decarb_PcaC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013595">
        <property type="entry name" value="Pept_S33_TAP-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08386">
        <property type="entry name" value="Abhydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02425">
        <property type="entry name" value="decarb_PcaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="21"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="Abhydrolase_4" evidence="5">
        <location>
            <begin position="240"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="CMD" evidence="4">
        <location>
            <begin position="340"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="427"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH85649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="448" mass="46161" checksum="234F7CCEAF7371BB" modified="2015-07-22" version="1">MTPPPRPRLLHHRVDGPAAAPPLFLGPALGTSLAVWDPQLPALARGHRVVRWDLPGHGVRPDGPLPGTGREAATRVRTGAVPRTGPAAATVAGTAAAAEPGAGAAQGAGGVGELAGLVLELADHLGIDRFRYAGISLGGAVGAWLAVHHPDRVDSLALVCTSARFGDPGPWLERAELVREKGTEPVAGAAPGRWFTPAFAGEPAARALVGDLRRADPYAYAALCEALAGYDLRADLPRITAPTLVVAGRDDPATPPAHARELADGIPGAGLTEVAHAAHLANVERPGPVLAALLAHFTGQGTPAESDAERRAAGTAVRRSVLGDAHVDRAAARTTGFTADFQDFITRYAWGEIWTRPGLSRATRSCITLTALVAGGHLEELAMHVRAALRNGLTPDEIQEVLLQSAVYCGVPAANAAFAVADRALAQPGQPGASGEADEPDEPERGVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NE94</accession>
    <name>A0A0F7NE94_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_29615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018932.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH85703">
        <property type="protein sequence ID" value="AKH85703"/>
        <property type="gene ID" value="AA958_29615"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_29615"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6251"/>
    <dbReference type="OrthoDB" id="1196738at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="31"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="310" mass="33839" checksum="AA5F3E55F2CE3CAE" modified="2015-07-22" version="1">MHDVVPAPDRVRATDGRILRVECSGDPCGRPVFLLHGMPGCRVGPRPRPMFLYQRGIRLISYDRPGYGGSDRRPGRRVADVVEDVTQVADALGLNRFVVAGRSGGAPHALACAALLPRRVTRAAALVGLAPRDAEGLDWFEGMAPGNVRVFRTAATDPERFVARLIPRSAAIREDPARLLNELRGDLTDEDRQIVSDRGIRAMLLRNYREALRKSPYGWVDDILALISDWGFDPADIQVPVLLWHGRKDAFSPVAHHSWLAGRIARATAVLDPAAAHFAALRALPEAIAWLLSDTPAASGAHTARGSRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NEH7</accession>
    <name>A0A0F7NEH7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glyco_trans_2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_11200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_11200"/>
    <dbReference type="EnsemblBacteria" id="AKH86686">
        <property type="protein sequence ID" value="AKH86686"/>
        <property type="gene ID" value="AA958_11200"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_11200"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2360"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047355">
        <property type="term" value="F:CDP-glycerol glycerophosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007554">
        <property type="entry name" value="Glycerophosphate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043149">
        <property type="entry name" value="TagF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04464">
        <property type="entry name" value="Glyphos_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="5"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="539" mass="59519" checksum="85798AC1003E601C" modified="2015-07-22" version="1">MPRFSVIVPAYRVQAYLDECLESVLTQSFTDVEVIAVDDRSPDFCGEIIDAAAARDPRLTAVHLSANVGLGRARNAGLERATGDYVLFLDGDDTLAPGALQALADRLTATADPDVLVYDYARTYWDGQHARNVRAGLLAERDPQVFRLADRPELLRLLMVVWNKAYRRNFVAAQGLSFPPGYYEDTPWTYPALLSAERIAVLDRVCVHYRQRRSGNILGTPGEQHLDVFEQYERVFAFLAARRLERWRPVLFVRMVDHLTTIFNRSERVPRHKRAEFFRRARALYVRYGTGPAPVAEGGVRARGAAGGALRAGRGPRARTRHLLVRLGTRRTFQLLGAAGRLLSRTRDLAARAARRARAGCGLLYYRLQLRLPLDPHLAVFAAYWYRGYSCNPAALEARARELVPGLATAWIARPAYAHTVPPGVRVLRPGSLACHRTLARGTYFDLTAEPPGRVCRTADEIADTFATGAHAAPAAAARLAAFRRRFCPYDDGHAAERVVRHVFLGEAGHPPVPGPGGVARGVPGVLPRPAGSAVVRSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NEH9</accession>
    <name>A0A0F7NEH9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phosphate transport system permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AA958_18065</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020184.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_18065"/>
    <dbReference type="EnsemblBacteria" id="AKH86860">
        <property type="protein sequence ID" value="AKH86860"/>
        <property type="gene ID" value="AA958_18065"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_18065"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3799"/>
    <dbReference type="OrthoDB" id="1325025at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011864">
        <property type="entry name" value="Phosphate_PstC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02138">
        <property type="entry name" value="phosphate_pstC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="80"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="124"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="293"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="87"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AKH86860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="327" mass="34484" checksum="968CAAF135EF4688" modified="2015-07-22" version="1">MRTTAPPPPEAPRKKGRRRSATRLGDRVFAGLSKGSGITLLVIMGAIAAFLAYRASLALAKNEGNFLTTFQWDANADPPVFGIAVLAFGTIVSSVIAMVIAVPIAVGIALFITHYAPRRVAAPLAYVIDLLAAVPSIVYGLWGALFLVPHLVGPYEWLDDLLGWTVVFSFDGSAPRSLMTAGILLAIMILPIITNVSREVFRQSPQTQQEAALALGATRWELIRMSVLPFGRSGVISASMLGLGRALGETMAVATVLSPSAILSAKLLEPGGGTFAQNIASAFKEAGEFGRDALIASGLVLFVITLLVNGAARLIIARRKEYSGANA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NEP2</accession>
    <name>A0A0F7NEP2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_31010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019137.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_31010"/>
    <dbReference type="EnsemblBacteria" id="AKH85909">
        <property type="protein sequence ID" value="AKH85909"/>
        <property type="gene ID" value="AA958_31010"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_31010"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6553"/>
    <dbReference type="OrthoDB" id="298863at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="SSF51695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="327"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="382"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="481"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="425"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH85909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="804" mass="85728" checksum="0FC713FAA3D44980" modified="2015-07-22" version="1">MTSFDKLRARLARAVRRVGEAAPPRNAAVLRWLAFVVAALATAVLVIAGTARSTVADAGFYRAALDREHAYDRLYDQVLVDPEASGVTRDLLARLPVPESVVTSNLKTVLPPTTARALAEDVIGDAVAYLRGEKDDLTLEVDLRPVLDNLGAVGNVHFADVVANLQDKPAPDYAAFQSDLGEAVDRIADGERPEGLPTLDLTEAQARTATDTVLRAVPADERAELRPRLLAALGVGDLATALAEVGPALFSGREESASSALRNTADGVSWDLASEFGSGGDELGPAREARAFTKLGLGWVQTGAILLGLASLGVLWRYGPRAPGRRLVRIGGTLACGGALTFVLALVVRGNVGGNIAAAPRNWPDTAARLLDDVQRTALDRLYTVALTTAAVPLTAGVLLTAGGWLWHRRATAIAAARTAAAERDAEAVAGAEPATGEAGGPEAVATPETGQADGGEAGPAGAAWPPVPAPVSPLPPRYRWGAVGVVAAALAGAVFVPNAFGGESDRRCNGREELCELRYDEVAQLASHNAMATSQDRFIAPLQDPSITGQLNDGVRALLIDTHRWETPPEITDRLAESDFTPTMQRQIRSVLNTVDPPRKGEWLCHAVCRGGALPLVPELQKIGDWLEQNPSDVVTLVVQDGISGADTRTAMRQAGLEDLAFTPADDPDEPWPTLGEMIDEDRRLVVFAEKADGPAPWYRNFYRYGMETPFAFRTPEDMTCTANRGGEDKQLFLMNHFITNSGGSRLDAGRINARDFVLDRARECERVRGRPVNLVAVDYATIGDARGAVKVLNDERLARREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NEZ1</accession>
    <name>A0A0F7NEZ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_27135</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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    </dbReference>
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH85297">
        <property type="protein sequence ID" value="AKH85297"/>
        <property type="gene ID" value="AA958_27135"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_27135"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5718"/>
    <dbReference type="OrthoDB" id="2133307at2"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH85297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="149" mass="16876" checksum="2AD0B91C0392A8E3" modified="2015-07-22" version="1">MDKSPHASDYGRWLMNVSRLNGVPLPLPAVLDDGTPDSIRIEPGDAYIHRETGVILAFVLTDDQGARHMFALDHADRSFEPLRDAIHAFLDSRFLRNLRNATPLGRLVNIAGAAVRHYWRWEKEPAGTGYYLYPQGKLLFRGTYKLEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NF01</accession>
    <name>A0A0F7NF01_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_25700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_25700"/>
    <dbReference type="EnsemblBacteria" id="AKH87035">
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        <property type="gene ID" value="AA958_25700"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_25700"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5417"/>
    <dbReference type="Proteomes" id="UP000034283">
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    </dbReference>
    <dbReference type="InterPro" id="IPR007995">
        <property type="entry name" value="DUF742"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH87035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="109" mass="11685" checksum="91F5AB758CF00976" modified="2015-07-22" version="1">MRPYAVTGGRTRPRYQLAIEALVQTTADPSRLTSQLPEHQRICRLCYELKSVAEVSALLTLPLGVARILVADLAEAGLVTIHQPGGGEAAGGQPDVTLLERVLSGLRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFA0</accession>
    <name>A0A0F7NFA0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_27565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018601.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_27565"/>
    <dbReference type="EnsemblBacteria" id="AKH85367">
        <property type="protein sequence ID" value="AKH85367"/>
        <property type="gene ID" value="AA958_27565"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_27565"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5808"/>
    <dbReference type="OrthoDB" id="1828423at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519589" evidence="1">
        <location>
            <begin position="33"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="340" mass="37021" checksum="7572ED625A337D0C" modified="2015-07-22" version="1">MTAVQTVRNRLLPILTALLLTLVPAAPTLAAAAPEALAGAAAQGGPRGDAEVVGVEQVGERLVDLSVRSPALGGRTVPVRLLTPDGWDARERGRNWPTLWLLHGCCGDYTSWTSATDVEDTDDLRNVLVVMPEAGWNGWYSDWWNFGAGGDPAWETFHTDELRRLLESDWGASSNRAVAGLSMGGQGALMYAARHRGMFRAAAAYSGAAHPLLNDESVNRIMGFFAGQGDDPRRVWGDPVDQRAIWQAHDPYYLAKKLKSTPVYLSCGDGTAGPLDPPGARDALEADFNRQNEALADELKRVGAKRVITNLYGPGTHRWAYWERELHASLPMLLDALKVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFS8</accession>
    <name>A0A0F7NFS8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">6,7-dimethyl-8-ribityllumazine synthase</fullName>
            <shortName evidence="7">DMRL synthase</shortName>
            <shortName evidence="7">LS</shortName>
            <shortName evidence="7">Lumazine synthase</shortName>
            <ecNumber evidence="4 7">2.5.1.78</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ribH</name>
        <name evidence="8" type="ORF">AA958_33360</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>(2S)-2-hydroxy-3-oxobutyl phosphate + 5-amino-6-(D-ribitylamino)uracil = 6,7-dimethyl-8-(1-D-ribityl)lumazine + H(+) + 2 H2O + phosphate</text>
            <dbReference type="Rhea" id="RHEA:26152"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58201"/>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
            <dbReference type="EC" id="2.5.1.78"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Cofactor biosynthesis; riboflavin biosynthesis; riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the DMRL synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.78" evidence="4 7"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019529.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_33360"/>
    <dbReference type="EnsemblBacteria" id="AKH86304">
        <property type="protein sequence ID" value="AKH86304"/>
        <property type="gene ID" value="AA958_33360"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_33360"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.7045"/>
    <dbReference type="OrthoDB" id="1680292at2"/>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00404"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009349">
        <property type="term" value="C:riboflavin synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000906">
        <property type="term" value="F:6,7-dimethyl-8-ribityllumazine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09209">
        <property type="entry name" value="Lumazine_synthase-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.960">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00178">
        <property type="entry name" value="Lumazine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034964">
        <property type="entry name" value="LS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002180">
        <property type="entry name" value="LS/RS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036467">
        <property type="entry name" value="LS/RS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21058">
        <property type="entry name" value="PTHR21058"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00885">
        <property type="entry name" value="DMRL_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52121">
        <property type="entry name" value="SSF52121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00114">
        <property type="entry name" value="lumazine-synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0686">Riboflavin biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="5-amino-6-(D-ribitylamino)uracil binding" evidence="7">
        <location>
            <begin position="58"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="5-amino-6-(D-ribitylamino)uracil binding" evidence="7">
        <location>
            <begin position="81"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="1-deoxy-L-glycero-tetrulose 4-phosphate binding" evidence="7">
        <location>
            <begin position="86"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>5-amino-6-(D-ribitylamino)uracil</name>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>5-amino-6-(D-ribitylamino)uracil</name>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>(2S)-2-hydroxy-3-oxobutyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH86304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="161" mass="16550" checksum="E3812F6C772E9F84" modified="2015-07-22" version="1">MSGKGAPELTVKNCEDLRVAVVAALWHEQVMDGLVDGALRALGELGIAEPTLLRVPGSFELPVVAKAMAGRGYDAVVALGVVIRGGTPHFDYVCQGVTQGLTSVGVETGVPVGFGVLTCDTEEQALARAGLADSVEDKGHEAATAAVATATALRNVAEPWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFT7</accession>
    <name>A0A0F7NFT7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_31220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH87166">
        <property type="protein sequence ID" value="AKH87166"/>
        <property type="gene ID" value="AA958_31220"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_31220"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6597"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH87166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="216" mass="22443" checksum="29414EA491BDFECF" modified="2015-07-22" version="1">MLNVGFRNVGDPGGPRSLDVHALLFDMDGTLVESAAAMDRHTRMWARRHSLDPEKVIRASHGRRDIDVIRELAPHADPYAELAWFDHLSCTDAAGVRAAPGAPRLLAALPPRRWGLVTSATRSVARSRMAAAGLPLPDVLVCAEDVAAGKPSPEGYLTAAALVGAPPSSCLVIEDADVGLRAARAAGMPALAVAGPPGPVHGHRIAGLGALCVTAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFX7</accession>
    <name>A0A0F7NFX7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_29230</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the leucine-binding protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018876.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_29230"/>
    <dbReference type="EnsemblBacteria" id="AKH85647">
        <property type="protein sequence ID" value="AKH85647"/>
        <property type="gene ID" value="AA958_29230"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_29230"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6162"/>
    <dbReference type="OrthoDB" id="776281at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028081">
        <property type="entry name" value="Leu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000709">
        <property type="entry name" value="Leu_Ile_Val-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13458">
        <property type="entry name" value="Peripla_BP_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00337">
        <property type="entry name" value="LEUILEVALBP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519463" evidence="3">
        <location>
            <begin position="25"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_6" evidence="4">
        <location>
            <begin position="29"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH85647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="395" mass="42010" checksum="254ABCCBF501E010" modified="2015-07-22" version="1">MRRLLPLLAAVALLATACGDDAGSDGEGPIHIGFIESLTGNYAPLGTEAAKTVELAIDQINKAGGIDGRKIELTTLDDKTAPDQAVVHFNKLKEDGVDAIIGSTFSNCALAVEPLAEREQIPYISLAPADEQVDPIQPHTFVVPATSSKYAESMLRYFEAEGITKIAVAYDTKSAYAVAGYEGMEKFASEYGVELVQTERYETNASDFSPVFTHVRNSDAEALAVWASGAPGVTLAKQYAAAGLDIPLVMTASQASKLWLEPVGDAAEDVYVQSAVGVVGDELPDGKLKDVIDKMADPFEKKYGYEPPQFAMDGYAGAQLIAAAFEKAGGTDKAEVRDALESMDLVTPTGRYTYSAEDHSGLDVVNISMNQVRDGKLVPTEWGRKQLAEAAEAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NGQ3</accession>
    <name>A0A0F7NGQ3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ABC transmembrane type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_30995</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019135.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_30995"/>
    <dbReference type="EnsemblBacteria" id="AKH85907">
        <property type="protein sequence ID" value="AKH85907"/>
        <property type="gene ID" value="AA958_30995"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_30995"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6550"/>
    <dbReference type="OrthoDB" id="1688736at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="29"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="87"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="175"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="221"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="282"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="88"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH85907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="314" mass="34962" checksum="C720076AAFD0C3DE" modified="2015-07-22" version="1">MTLTKVRPERAAAPRPAGRGGGRFRRGEWVGYAFLSPALLLFLAFVAGPFAVAIVLAFFSWDMLTPAEFNGVGNFTEMFSDPLLYEALANTFVFALASVLTHLGGGLLLAMGVNRMMRRALSYFVRTTLFFPFVISWAAVALLWKYVLDPTFGLVTHYAGEIGVEPPEWFTDPAWALPAIIAIDFWHTIGFTFVIMLAGLQTVPRELHEAARVDGARPHQVFWRVTLPMMSPTIFFAAVVTFIGAFQIFDPVQIITPDGGPENSTITIVMYLYQKGFQSFQIGYAAAVSILVFVIMMAVTLLQFWGSRKWVHQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NH85</accession>
    <name>A0A0F7NH85_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_09485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019907.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86643">
        <property type="protein sequence ID" value="AKH86643"/>
        <property type="gene ID" value="AA958_09485"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_09485"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2000"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="59" mass="6071" checksum="8734F82E95DCDB47" modified="2015-07-22" version="1">MSALTAAHDLAVTLASASESGGGGGHEGDSSPNAYFVGGSTLFVLLLLLFITTRFNRDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NH89</accession>
    <name>A0A0F7NH89_9ACTN</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_09955</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_09955"/>
    <dbReference type="EnsemblBacteria" id="AKH86648">
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        <property type="gene ID" value="AA958_09955"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_09955"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2096"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002520092" evidence="2">
        <location>
            <begin position="26"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="332"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="376"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="411"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="455"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="484"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="540"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="776"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="823"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="881"/>
            <end position="905"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH86648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="920" mass="94284" checksum="8DB07A67112F9963" modified="2015-07-22" version="1">MRTRLRAAPGGAVALALLVLVTAFLAAAFPRGVDTYEDREARRLIEGATAAERNVALTAQPDPEVRFEDRAESMGGRVVERFVRPVLGEFREPLRAERGQVSYGVRTKPVLVTDDPWLPKTDGQRPEVQLDARAGVGERARVVEGRLPEPTAYEAEGGGDVALEAAVTAATADRLHLRVGSRVHIPRSEGTVAVEVTGILEPKAPGSDYWSVDPLLRTPELRQRPESLEPQRYWAAAFLLHPDSGPALFAGTQSFGPSFEDAGASPYWNVPVAGGGLRGRNVAAVLDALSALQEGPGFERLAQRTGGTLDVSTGATGLLAGYTGVREAVTPVVAVAAFGVGAVAAVVLGMSGGLAASRRRAELALLRSRGGSLRSIATRLLAENAAAVLPAAAAGYGLAVLLLPGARHAPALLAAGATAVLALCALPLLAVAAVRRPRPPVRTDLVRARPSRQRLVAEVTAVVLAVGAIVVLRRRGDADGGADALVSAAPVLVGSVAATVFVRLYPLPLRLAARPAAWARGALGFLSLARAGRAPAASALPLLALLVALTTASFGGSVLAGVADARATASLHSVGGDARLTSAAPLPDGLAAQAEKVGGVRHLAAVSTESGLQVIGLSGDLTLLTVDAAAYARLSADLGLGPFDAGRLRDGNGGRALPALVSPGVADLIGDGTLGLQSSRGRITAEVAAVRTTTPALTGGQFAVVDAESVARHLPGTESVTEARPDTLLLSAAGGLDGAALRELVRDSAPAAGLLLRDDVTDDLAASELQRGAERLYAAAVVAATGYALLAVLLSLLRAAPERVALLARLRTMGFSRRHGRRLLVLEALPQLVAAGLVGALAGLVTVRLLGPGIDLSALALGEESPDLLGPGGAELRADPLALALPSVAVPALALAAVLVQAWWGGRRRAVQELRAGERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NI61</accession>
    <name>A0A0F7NI61_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pyridoxamine 5'-phosphate oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_30230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_30230"/>
    <dbReference type="EnsemblBacteria" id="AKH87139">
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        <property type="gene ID" value="AA958_30230"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_30230"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6387"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="F420-binding_dom_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03618">
        <property type="entry name" value="Rv1155_F420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="1">
        <location>
            <begin position="5"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH87139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="129" mass="13961" checksum="8E705745F52B3B51" modified="2015-07-22" version="1">MPGVTPGVAAFLNAPHAAVLTTLRQDGSPHLAPVRFTWDPGTGLARVLTVRTARKARNLLASPGAATALCQVDGFRWVTLEGPAEVSDHPARVEEGLRRYAERYWSAPPNPPGRVVVELRVERVMSLNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NI77</accession>
    <name>A0A0F7NI77_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_00990</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019690.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_00990"/>
    <dbReference type="EnsemblBacteria" id="AKH86472">
        <property type="protein sequence ID" value="AKH86472"/>
        <property type="gene ID" value="AA958_00990"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_00990"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.219"/>
    <dbReference type="OrthoDB" id="1833499at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
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        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="7"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="39"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH86472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="248" mass="26049" checksum="C3CF1E4C0D5195D0" modified="2015-07-22" version="1">MTAATAIDVRELTKDYGDVRALDAVTFTVRPGRVTGFLGPNGAGKSTAMRLVLGLDRATSGTAAVGGRPYPELAEPLRHVGALLDAQAAHGSRTGRAHLRALAASNGLPDARVDEVLRLTGIESAAGRRVRTYSLGMRQRLGIAAALLGDPPVLLLDEPSNGLDPEGIVWIRRLLRGLADEGRTVLVSSHLMGETAAFADHLVVLGRGRLLADAPLAEFVEGNSGGLEEAYLRLTAGAAEFTSETREV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NIA3</accession>
    <name>A0A0F7NIA3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dihydroxyacetone kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_01775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019714.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_01775"/>
    <dbReference type="EnsemblBacteria" id="AKH86492">
        <property type="protein sequence ID" value="AKH86492"/>
        <property type="gene ID" value="AA958_01775"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_01775"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.387"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004371">
        <property type="term" value="F:glycerone kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012737">
        <property type="entry name" value="DhaK_L_YcgS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004007">
        <property type="entry name" value="DhaL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036117">
        <property type="entry name" value="DhaL_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02734">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01120">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101473">
        <property type="entry name" value="SSF101473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02365">
        <property type="entry name" value="dha_L_ycgS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51480">
        <property type="entry name" value="DHAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DhaL" evidence="1">
        <location>
            <begin position="5"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="203" mass="20431" checksum="37D7C9124E8D0F83" modified="2015-07-22" version="1">MLDAEFFRRWMLTTAAAVDREADRLTELDSAIGDADHGANLKRGFTAVRAALEEEPPQTPGAVLVLSGRQLISKVGGASGPLYGTLLRATGKALGDDAEVTDAALRAALDEGVGAVAKLGGAAPGDKTMLDALTPAVAALGDGYGAAHAAADKGAEDTIPLRARKGRASYLGERSIGHQDPGATSSALLVGALADTVEAVSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NJG6</accession>
    <name>A0A0F7NJG6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Peptidase S54</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_20465</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_20465"/>
    <dbReference type="EnsemblBacteria" id="AKH86927">
        <property type="protein sequence ID" value="AKH86927"/>
        <property type="gene ID" value="AA958_20465"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_20465"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4313"/>
    <dbReference type="OrthoDB" id="2053476at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="SSF144091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="162"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Rhomboid" evidence="6">
        <location>
            <begin position="41"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH86927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="190" mass="20170" checksum="037426A9246F0AE3" modified="2015-07-22" version="1">MKRAGMVMLAWVALLWVLEAVDQAGGNKLDTYAITPRDFGELRDVVPASFMHFGWDHLSANTGPLLVLGFIAAMRGIGRFVGVVAVIVLVSGLGVWLVSPAGTATAGASGVVFGLFAYVAVRGFVDRRMSDVLIGIVVALVYGSMVWGALPTDQVLEQSISWQAHLFGLLGGVLAAFYFSDRRRAALQGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MXF4</accession>
    <name>A0A0F7MXF4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_00620</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH80915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014281.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_00620"/>
    <dbReference type="EnsemblBacteria" id="AKH80915">
        <property type="protein sequence ID" value="AKH80915"/>
        <property type="gene ID" value="AA958_00620"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_00620"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.144"/>
    <dbReference type="OrthoDB" id="1943389at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="2">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="1">
        <location>
            <position position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH80915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="75" mass="8032" checksum="99E1387E47E831A0" modified="2015-07-22" version="1">MTTIDDLVVLIRDELGLPVSVEDADRPLDEIAGWDSVHLLWLTAAIERRTGRSVSLPDLLEAGSLSGIHKAAVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MZ94</accession>
    <name>A0A0F7MZ94_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_01435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014411.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_01435"/>
    <dbReference type="EnsemblBacteria" id="AKH81046">
        <property type="protein sequence ID" value="AKH81046"/>
        <property type="gene ID" value="AA958_01435"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_01435"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.316"/>
    <dbReference type="OrthoDB" id="1659652at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045998">
        <property type="entry name" value="DUF5954"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19379">
        <property type="entry name" value="DUF5954"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="336" mass="37560" checksum="F0B7614669432DF0" modified="2015-07-22" version="1">MPDSTDREPRRVTIRLPDPDDPVGRVTETDAARYAMRYPYMVVRGPLFGVAEQRPGDAPRWRLCSDMDSGMPQDARDALNSRLWFTARDKAGDREQRRRLLDAVAVLEREPVDEVRVGDVRHRIVRADEFTRTDGRRPEPPRPTDPDSDGWEDDGTPSRTEGFVIDPDAATGPAAALLRMALKDYAYSSPRFPRQVLDDSAAAVVSHPDVVMLPPAFRVLEQHETSWEMIGNQHATPQQARRLLADFLTHEHGFPPPMGPPAADAAACRRAANAYRRRRRGNEADVCGRRFVIARVERTMRVGADGPETPRPSDVDDYGPSRIHPTMDADGTVTPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0A5</accession>
    <name>A0A0F7N0A5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_03345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_03345"/>
    <dbReference type="EnsemblBacteria" id="AKH81376">
        <property type="protein sequence ID" value="AKH81376"/>
        <property type="gene ID" value="AA958_03345"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_03345"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.711"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="557" mass="61135" checksum="4CC364E56BD1E484" modified="2015-07-22" version="1">MGAAVAGSEGLEFDFAPRAQVPLSGAQGQTAATHALASTAYRDSAVTKLLDANNDWSKSEFKKGRLSLFEPNLGEAFARAVTVRMLADGRKPLIQSFGTEPQAVLEHCLAANRYRKERDTRLTVVMGVFGLLFLPGVLLWLGVFQLRRTLAGASDKRVGAVGYVLLGLIGVAAIYLFLTMPLDGLLYIYLRGLLVAPIIGWFWANRICEKYAKGLREHWTALLSGGGLGAKIPEAVPSNPGEASAERLRLGLAKLSAEQHSNVVFYAGPKGILGMGTRWGAWHLAEDLKPKESGGEINPFRSWDIVKAVHDQLRMLERTPLHTGGFPAPAIKHWIVSPIGEGAGEVARPGGTIVDGYSVRDFEVQRICNEQQFGAGNRHYLGVQFTLWDGQLVITLLVSVTVLHHTLRIEVTGHALGPVHPLFTSKPSRETKTVSGMKFWETKEKPLPLVRTREVVRLAARAPFTWYPPLLDYLGGKLKLPEPFGLRHVWADKPWRHRFMADDALRAATPVLRVVHQAALRVLEENNVDTTNFAGRSMALSGMVQSAEPRQADVYDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0T9</accession>
    <name>A0A0F7N0T9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_08355</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AKH82240">
        <property type="protein sequence ID" value="AKH82240"/>
        <property type="gene ID" value="AA958_08355"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_08355"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1763"/>
    <dbReference type="OrthoDB" id="1619224at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="176"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="277"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="93"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH82240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="315" mass="34189" checksum="279D695F982C2306" modified="2015-07-22" version="1">MSTAVSASTKPGTSPPGKPQRRGRRSRGEARLAWYLITPAILLLAAVIGYPLVKAVYLSLFSDTIGEEAEFIGLGNYRRALTGDASADFWSAVQVTLLFAVVTVLLEVVIGTAMALVMHRAFRGRGLVRASVLVPWAIPTALTSVLWQWMLQPDGIVNGMTGETVLWTGSEWPATWAIIIADTWKTAPFLALLVLAGLQLIPDELHEAARVDGAGVWRRFRSITLPLLMPALMVAVLFRLLDVLRIYDLPQILTGGANGTTTLSMLVVQASVEQTKFGYGSALSTLTFLFIFVVALLFVRFLGTTLMPAEEGKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N157</accession>
    <name>A0A0F7N157_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sugar ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_01965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_01965"/>
    <dbReference type="EnsemblBacteria" id="AKH81138">
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        <property type="gene ID" value="AA958_01965"/>
    </dbReference>
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    <dbReference type="PATRIC" id="fig|444103.5.peg.424"/>
    <dbReference type="OrthoDB" id="1746871at2"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
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        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519059" evidence="1">
        <location>
            <begin position="25"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="424" mass="47231" checksum="2630B7C76482B3F9" modified="2015-07-22" version="1">MTRRSLLRGAALGAGAVTLPTLLAACGSGPGGDGKTVTLGSNASDEVPRKAFQDAFDLFEKNSKKKVEVNTVDHNTFQENINRYLQGRPDDVFMWFAGYRMQFFAERGLLSEISDLWKGFDGFSGALKDQSTGADGKQYFVPFYYYPWAVFYRKSVFEQGGYEIPTTFDQYTALAKQMQKDGLVPFAFGDKDGWPAMGTFDYLDMRANGYEFHKSLMAGEESWTDPRVREVFDLWRGLMPYHDKGANGRTWQEAAQTLAQKKTGMAVFGLPQPGQQFSEADREDLDFFPFPEISPEHGQDAVEAPIDGFLMSSKVKNEEGAEELLKFLATPAAEDAYLKSDPNNIAVHSGADTSAYSTLQKKAAELVSNAKHISQFLDRDTRPDFASTVMIKAFQDFIDDPDDIDGLLKGIESQKKTIFAEGQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N165</accession>
    <name>A0A0F7N165_9ACTN</name>
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        <submittedName>
            <fullName evidence="2">Cytoplasmic protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_02030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_02030"/>
    <dbReference type="EnsemblBacteria" id="AKH81148">
        <property type="protein sequence ID" value="AKH81148"/>
        <property type="gene ID" value="AA958_02030"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_02030"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.438"/>
    <dbReference type="OrthoDB" id="1424960at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="B3/B4_tRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020825">
        <property type="entry name" value="Phe-tRNA_synthase-like_B3/B4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03483">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00873">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B3_4" evidence="1">
        <location>
            <begin position="64"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="222" mass="24045" checksum="A02F391879B488B0" modified="2015-07-22" version="1">MTLRTHVADDVRALAPGFAHVAVVARGLVGGPSDAAGAALLDDAARRLAARLGGTPPQQDPHMQAWRAAYAAFGAKPSKFRNSAEALARRALADAGLPRINRLVDIYNAVSVAHLVPVGGEDTDHIDGDMHLIRATGEERFDEEHPDPGEVVWRDGTGVTCRRWNWRQGVRTRLTEDSTNALFLLERQEPMTYDELTAAAEELAEALQKSSPGAEIEIRDPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N1B5</accession>
    <name>A0A0F7N1B5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">D-ribose transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_02210</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014543.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_02210"/>
    <dbReference type="EnsemblBacteria" id="AKH81179">
        <property type="protein sequence ID" value="AKH81179"/>
        <property type="gene ID" value="AA958_02210"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_02210"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.475"/>
    <dbReference type="OrthoDB" id="551294at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="7"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="255"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="39"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH81179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="503" mass="53591" checksum="976381053E3490E2" modified="2015-07-22" version="1">MTEVPVLAARGLSKSFGAVRALQDVSLTLHAGEAHALAGENGAGKSTLIKTLAGVHSPDAGQLLLDDAPVAFHGPADARDAGIAVIYQEPTLFPDLSIAENIFMGRQPRRTLHRIDRAAVHDATAALMRRLGVDLDPDRPARGLSIADQQIVEIAKALSFDARVLIMDEPTAALTGSETARLFAVVEALRAEGAAVLFISHRLDEIFRLCRRVTTLRDGRWIATDEVAALTEDDLVRRMVGRDLDELYPKQDAELGGTALSVRRLTREGVFHDVSFDVRRGEIVALAGLVGAGRSEVVQAAFGVDTPDAGEVHVAGRPLRRGSPTAAMDAGVALVPEDRRQRGLVMEMSIERNIGLTGLGRLGSAGLVKRTLERGRAADWAAKLRLKYGRLSDDVGVLSGGNQQKVVLAKWLATEPSVLIVDEPTRGIDVGTKAEVHRLLSELAAGGLAVLMVSSDLPEVLGMADRVLVMHEGRLVAEIPRAEATEESVMTAATGRGAREAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N1E3</accession>
    <name>A0A0F7N1E3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Metallo-beta-lactamase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_09155</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH82365">
        <property type="protein sequence ID" value="AKH82365"/>
        <property type="gene ID" value="AA958_09155"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_09155"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1931"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="2">
        <location>
            <begin position="102"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH82365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="379" mass="41262" checksum="79AABE34646715F1" modified="2015-07-22" version="1">MRRIRPASFGAEPAGARLARILKSPNYDPEAGAFRNPVPAGIGPQPGGGSRGEMFRALLRRDGRKPAAPIPVQRPDLSAPPADGLRLTWLGHATVLAEIDGRRVLFDPVFGERCSPFSFAGPRRFHRVPLPLGELGPLDAVVISHDHYDHLDMSTVRELRKAVAPDVLFAVPLGVGAHLERWGVPRDRIAELDWNESTGAAGLTLTATPARHFCGRGIRNKQRTLWASWSVRGPEHRVFHSGDTGYFPGFAEIGADHGPFDAAMVQIGAYSEYWPDIHMTPEEGVRAHLDLRGGVLLPIHWGTFNLAPHRWEEPAERTAAAAAAADVRAAIPRPGEPFEPSAQTLPTTPWWQEIAAPERTPQARGGRKAAAKPSPATEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N1N4</accession>
    <name>A0A0F7N1N4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sugar-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_09870</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the bacterial solute-binding protein 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_09870"/>
    <dbReference type="EnsemblBacteria" id="AKH82490">
        <property type="protein sequence ID" value="AKH82490"/>
        <property type="gene ID" value="AA958_09870"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_09870"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2079"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018313">
        <property type="entry name" value="SBP_3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01039">
        <property type="entry name" value="SBP_BACTERIAL_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="PBPb" evidence="5">
        <location>
            <begin position="92"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="38"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="60"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH82490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="329" mass="35251" checksum="FBA50B80787E4619" modified="2015-07-22" version="1">MRTAKAPRTRRNLRGWGGVAGTAAAVALTAALLPGLTGGDRQDGPADDRAGGAVAAQPAKSSQEECQTPEASLRPSGTASGDGVERIVDRGYLIAGIDQNSYQWGYRNPLTGKLEGFDIDLARAIAEEILGDETKVVFRSIPTSQRIPALQDKDVDVVVRTMTINCERIQDVAFSTEYFTGDQAVLAPADSEITGFDESLDGERVCTAEGSTGEDALEKGDYGAKVKTVPNQLDCLVRVQLGKADAVVTDNALAAGQAAQDPSMKLFGTLDQPEPYGVAMNLDDDDLVRRVNKLLDDYRKDGRWQDAYDKWLADAMPGIEGPPAPKYKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N258</accession>
    <name>A0A0F7N258_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glutamine amidotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_03865</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014826.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_03865"/>
    <dbReference type="EnsemblBacteria" id="AKH81469">
        <property type="protein sequence ID" value="AKH81469"/>
        <property type="gene ID" value="AA958_03865"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_03865"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.812"/>
    <dbReference type="OrthoDB" id="1628378at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011697">
        <property type="entry name" value="Peptidase_C26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044668">
        <property type="entry name" value="PuuD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43235">
        <property type="entry name" value="PTHR43235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07722">
        <property type="entry name" value="Peptidase_C26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH81469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="232" mass="24487" checksum="7852104E66BDEF21" modified="2015-07-22" version="1">MSRTRPLIGVSTYLVDEAAWGRWHLPAALLPAGYHRLTQRAGGLAALLPPDAPARAAETLRRLDGLIIAGGPDLDPARYGAEADARTDPVTPTSRERDEWELALIEAALAAELPLLGICRGAQLLNVVRGGTLRQHMEGHRERPGVFGAHEIKPVPGTRLASLLPEAVTVPAYHHQAVADLGTGVIASAYAADGVVEALELPDAGGFALGVQWHPEMGEDARVLRGLVEAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N262</accession>
    <name>A0A0F7N262_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_03955</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014840.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH81483">
        <property type="protein sequence ID" value="AKH81483"/>
        <property type="gene ID" value="AA958_03955"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_03955"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.830"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="74" mass="7923" checksum="E85511DA12D266C9" modified="2015-07-22" version="1">MMWPMTAVALGFLGLVALAVPALRVGLEVQRLARRLDDAAQQISRATSDLERSAADVARRAGSTRDLPGSDFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N267</accession>
    <name>A0A0F7N267_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_03930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014836.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_03930"/>
    <dbReference type="EnsemblBacteria" id="AKH81479">
        <property type="protein sequence ID" value="AKH81479"/>
        <property type="gene ID" value="AA958_03930"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_03930"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.825"/>
    <dbReference type="OrthoDB" id="1262147at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="402"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="466"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="493" mass="52408" checksum="63F17080A4918394" modified="2015-07-22" version="1">MITYDDLTPPERELWAAFSEGRPVDLRVGDAALDDPAGGVAWGPERTVRAAVLAALLLGAHPPQPGAIPALRLAGARITGGLDLTGAETTHRLRLEHCYLHEEVVLTSATTASVHLDDSVLPRVDARLARVEGVLSVRRSRVAGALLATNARISGELLLHGARLTGENGWSLFAGGLEVDGAVFCTHGFTGGGGIRLIGARLSGGLFLDGARIGAADGLALLLDHAEITTVRLTDGFAAAGRLELRGTHIADLLSLDGARLGDCTGIDCARMQATDFRFTPAVRPAGPVSLDGTQVTTLHDDPESWPVTVLLDGFAYGSIQSAGAAGKDSVPRRLDWIRRGTGYAPQPYEQLAAWYRQIGHVDDARRVLLAKQRARRRTLRPAGRAWSLLLDGTVGFGYRPWLAGLWLAALTLLGSLVFAAGDDRPVREGEGPDFHPVVYALDLLIPVGGLGQRDFWYMSGGAAQILSYVLVATGWLLTTALVAGMTRTLERT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2B3</accession>
    <name>A0A0F7N2B3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_04215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014883.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_04215"/>
    <dbReference type="EnsemblBacteria" id="AKH81528">
        <property type="protein sequence ID" value="AKH81528"/>
        <property type="gene ID" value="AA958_04215"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_04215"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.884"/>
    <dbReference type="OrthoDB" id="816674at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="397" mass="44264" checksum="B1341AC78FFB0C96" modified="2015-07-22" version="1">MTAVLPDFPMPREHPLDPPPQYRALSAERPVFQVRTPRGDTAWVVTRHEDVRAVLTDRAFSSDPRTPGFPTYVTGDVPPPQGFFMQADPPDHGRLRRTVTREFLINQMEALRPTMRRILDGLVDRMTADDRTSGDLVREFALPMAAMTICEILGVPFEDHVLFVSLTDTVLDRSSTPEQAVQAAGELMGYFDRLVTAKEKEPSEDLFGRMVARSADGGLTHEELVGMAALLLLGGYDTMAQIIGIGTVTLFEHPDQLEALRRDDTLLPGAVEEMLRYLSINHAGLPRGVTEDVVVGGQQIRAGDGVLVMLNAANRDEDVFEEADRFDIRRVNNSKHLAFGHGFHKCVGATLARVELTEVFGGLFRRLPGLRPTRSLDELPFRHDMVLYGVRELPVTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2F8</accession>
    <name>A0A0F7N2F8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Pyruvate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_04450</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014919.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_04450"/>
    <dbReference type="EnsemblBacteria" id="AKH81564">
        <property type="protein sequence ID" value="AKH81564"/>
        <property type="gene ID" value="AA958_04450"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_04450"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.938"/>
    <dbReference type="OrthoDB" id="351701at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="5">
        <location>
            <begin position="5"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_M" evidence="3">
        <location>
            <begin position="193"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="4">
        <location>
            <begin position="383"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH81564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="580" mass="61741" checksum="937967B8A5C4B9F4" modified="2015-07-22" version="1">MSSAKVADQLVEVLLQYGVKRIYGVVGDSLNPLVDAIRRSDGVIEWIHVQNEEAGAFAAAAEAQVTGELAACAGSCGPGNTHLIQGLFDAQRSGAPVLAIASHIPSTQIGSGYFQETHPEKLFDQASGYCQLISQPEQMPRIARIAAQHAVGANEVAVLVLPGDIADKPAAKPTGHTVPCARPAAIVPDPQTVRELADALNGADRVALFAGAGVRGAHAKVMRLAETVKAPVGHTLRGKEWIQYDNPYDVGMIGLLGYGACYDALQDADLVVMLGTDFPYDAFLPQGKTVQIDIDATRLGRRTPLEVAVHGDVASTLDAVQPLLREKRERRFLDATLRKHERSLTKVVEAYTSNVDKHVPIHPEYAARLLDTLAADDAVFTVDTGMNNVWAARYLTPNGRRRVIGSFTHGSMANALPHAIGAASADRDRQVISLSGDGGLGMLLGELITVKQHDLPVKTVLFNNSSLGMVKLEMLVDGLPAYGTDHSKVDFSAIARGVGIPAWRVEKPGEIEGALREALAAKGPALVELITDSNALSIPSRITLEQVRGFALAAGRTVLEGGVGTMLDLARSNLRNIPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2N4</accession>
    <name>A0A0F7N2N4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NAD kinase</fullName>
            <ecNumber evidence="5">2.7.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ATP-dependent NAD kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ppnK</name>
        <name evidence="5" type="synonym">nadK</name>
        <name evidence="6" type="ORF">AA958_04975</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + NAD(+) = ADP + H(+) + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:18629"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the NAD kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.23" evidence="5"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015009.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_04975"/>
    <dbReference type="EnsemblBacteria" id="AKH81654">
        <property type="protein sequence ID" value="AKH81654"/>
        <property type="gene ID" value="AA958_04975"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_04975"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1046"/>
    <dbReference type="OrthoDB" id="1463423at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019674">
        <property type="term" value="P:NAD metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006741">
        <property type="term" value="P:NADP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00361">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002504">
        <property type="entry name" value="NADK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01513">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="SSF111331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 5" id="KW-0520">NAD</keyword>
    <keyword evidence="3 5" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5 6" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="73"/>
            <end position="74"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="147"/>
            <end position="148"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="188"/>
            <end position="193"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH81654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="297" mass="31701" checksum="53E27850F8252573" modified="2015-07-22" version="1">MTDRTVFLLAHTGRPAAIRSAELVVRGLLRCGVGVRVLAGEAADLPLPPEAELVEAGPGVMDDCELLIVLGGDGTLLRGAAFARKSGVPMLGVNLGRVGFLAEAERDDLDKVVDRVVTREYEVEERMTLDVLVRNGGRTVHADWALNEASVEKAARERMLEVVTEVDGRPVSRFGCDGVVCATPTGSTAYAFSAGGPVVWPEVEALLMVPISAHALFAKPLVTSPDSILAVEVQPNNQHGVLWCDGRRTVDLPSGARVEVRRGAVPVRLARLHHASFTDRLVAKFALPVAGWRGAPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2S5</accession>
    <name>A0A0F7N2S5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cobyric acid synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">cobQ</name>
        <name evidence="7" type="ORF">AA958_05285</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 4">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CobB/CobQ family. CobQ subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015063.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_05285"/>
    <dbReference type="EnsemblBacteria" id="AKH81709">
        <property type="protein sequence ID" value="AKH81709"/>
        <property type="gene ID" value="AA958_05285"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_05285"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1109"/>
    <dbReference type="OrthoDB" id="744477at2"/>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015420">
        <property type="term" value="F:ABC-type vitamin B12 transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01750">
        <property type="entry name" value="GATase1_CobQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00028">
        <property type="entry name" value="CobQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002586">
        <property type="entry name" value="CobQ/CobB/MinD/ParA_Nub-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033949">
        <property type="entry name" value="CobQ_GATase1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004459">
        <property type="entry name" value="CobQ_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011698">
        <property type="entry name" value="GATase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21343:SF1">
        <property type="entry name" value="PTHR21343:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01656">
        <property type="entry name" value="CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07685">
        <property type="entry name" value="GATase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00313">
        <property type="entry name" value="cobQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="3 4" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CbiA" evidence="5">
        <location>
            <begin position="8"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="GATase_3" evidence="6">
        <location>
            <begin position="265"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="344"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH81709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="509" mass="53514" checksum="ABDC22BAD425BAA7" modified="2015-07-22" version="1">MTARAGGLLVAGTTSDAGKSVVTAGICRWLARRGVSVAPFKAQNMSLNSYVTREGAEIGRAQAMQAAAARTEPTALMNPVLLKPGGEAQSQVVVLGRPVAELSAAGYHGERQRALFDTVTDCLEELRRAYDVVICEGAGSPAEINLRHSDIVNMGLARAARLPVVVVGDIDRGGVFASFFGTTALLSAADQGLVAGYLVNKFRGDVSLLEPGLSMLRGLTGRQTLGVLPFRHGLGIDEEDGLRLSLRGLIRELPAEPPHGREALRVAVVPVPLMSNFTDVDALAAEPGVAVQFTDRPEELAEADLVVLPGTRGTIRALAWLRERGLDAAVARRAAQGRPVLGICGGFQMLAERIGDAAGVEARPAQSVAGLGLLPVRVEFAARKTLGRPAGTALGEPVAGYEIHHGVADVRGGEPFLAGCRVGQVWGTHWHGALENDGFRRAFLRQVAADAGRAFVPAPDTSFAALREEQLEKLGDLIEEHADTKALLRLIEAGAPGDLPFLPPGAPTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2U3</accession>
    <name>A0A0F7N2U3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sugar-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_12595</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH82930">
        <property type="protein sequence ID" value="AKH82930"/>
        <property type="gene ID" value="AA958_12595"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_12595"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2646"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003587">
        <property type="entry name" value="Hint_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036844">
        <property type="entry name" value="Hint_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030934">
        <property type="entry name" value="Intein_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022385">
        <property type="entry name" value="Rhs_assc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031325">
        <property type="entry name" value="RHS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006530">
        <property type="entry name" value="YD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05593">
        <property type="entry name" value="RHS_repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00306">
        <property type="entry name" value="HintN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51294">
        <property type="entry name" value="SSF51294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01443">
        <property type="entry name" value="intein_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03696">
        <property type="entry name" value="Rhs_assc_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01643">
        <property type="entry name" value="YD_repeat_2x"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50818">
        <property type="entry name" value="INTEIN_C_TER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="INTEIN_C_TER" evidence="2">
        <location>
            <begin position="2025"/>
            <end position="2051"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="676"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1210"/>
            <end position="1229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1522"/>
            <end position="1550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1778"/>
            <end position="1801"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1884"/>
            <end position="1913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1884"/>
            <end position="1898"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH82930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="2177" mass="234811" checksum="A75B63D4D04A3DCF" modified="2015-07-22" version="1">MKGAKQLATGRAEITTLDSTTAEKTGANGPVFSITGKDGTQGRAGVELDYSSFAEAYGGTYASRLTLVQLPACALTTPAKSACRTATPVATTNDTESQILTGNAVALRAGEPTVLAVTTAAEGDQGDFKATQLSPSATWNTNLNTGDFTWEYDIPVPEVPGELTPKVGLSYSSGGVDGRTGGTNNQSSWVGDGFEMWPGFIERRYKPCADDGVEHPDGNKPADLCWGYDNAFISFNGQAGELVPAGADEWKLKKDDGTRIKRLASADRGNGDNDGEYWRLTDPNGIRYYFGYNRLPGWASGKETTGSAWKVPVFGDDSGEPCHDAAGFGSSWCQQAWRWNLDYVVDPHGNAISYYYHQEENSYGRNLKADNNTRYTRGGSLDRIEYGLKHSSVYDTKPLAKVDFSSSERCLPNAQTTCDSISTDSAYWYDTPWDLNCGETATCDQGRLAPSFWTRKRLTEVTTEVLKSDGTYGPVDSWKLQHRWGQADIDYQLLLDSIQRTGHTATPAITLPKTTFTYTQLANRLDKTGDGYAPFIKARLESISDEYGGKITANYSEPACNWNDLPTPQTNTTRCFPQYIGGSATADPERQWFNKYVTTSVASTDRTGGAAGSMTRYEYLGGAAWHYDDDDGLTKEKFKTWSQWRGYGQVRVKAGGLLGDEAMKSQSDTYFLRGMHGDRESPAGGTKNVSVSLGTGEGDPLTDHESAAGFAYKTVEFSGPGGKVLNKAVSRPWHHQTAKKERNWGTVTANFTGAAQRKTFTSLDNGAGTDWRTTQVSNTYDTIAGRVTHVDDFGDTSTAADNRCTRTTYATNADDNILTLPARVETVAKGCDGTVDRTKDVISDTRTAYDGDAITAAPGKPTKGDATATAVLKSHTASEAVYLESGATYDAYGRETSSTDLTANLVFDAAGAFVSRTQRDDARTDKTQYKPASGLVTQVVTTSPPAKAGDATTAQTTTTDVATLRGLPIRETDTNGKATEFAYDALGRSTKVWLPNRTTSQLPTHEFDYQVTEGKPVAVSTKTLTEGGGGQLTSYLLYDGFLRERQTQTPGPEGGRLVNDVFYDERGLREKIFSQYYTTGAPAAALFEPADALSVESQTWFGYDGLGRVIKEEQVSGNGEGNPHRILATTTTSYHGDRTTVIPPQGGTATTTLTDARGQTTELRQHHARAAEAAYDTTRYDYTPRGELAKFTDPAGNEWSYSYDQLGRQITANDPDKGTTTSTYDDRGQLTTTTDARGVKLAHVYDGLGRKTELRDDSPTGTLRSQWVYDTIAGAKGQLAASTRYEDGAAYTSRVTAYDQLYRPYRTAVTIPAKEGALAGTYQDGTSYKANGLVAGETYSAAGSLPGGGMTFAYDDILRPTKAYGAWGSSSVLAYRNTGQPMQYDLAASDGGRRARITNTYEWGTQRLKNSRVDRENVPGVDKYATYAYDETGNITSVSDVNRTGTDNQCFTYDYLRRMTEAWTEADENCETAPSPGIVGGPAAYWQSFTYDKAGNRTTHTDHTAPGGAAQDTKYTYSYPTPGQPQPHALTDVTSTGPTGTSTDSYTYDEAGNTKTRTLAGSTQNLTWDAEGHLASVSVPDGAGGTKSTSYLYDADGNRLIGRTPTETTLYLGHTEVTLPKGATKAKATRYYDLGDGHQAVQEDDGSVWFTIADHHATGQLAVNAANTDLQRRRELPFGNPRGQEPADWPGSKGFVGGTTDTTTGLTHLGAREYDPATGRFISVDPLMDLTDPQQWQGYAYANNNPITHADPTGLFWNGIIDLIQETVERVVQHKNYNRSVSSGGSSSGGGGGGGGTTTATQATFTTAPSCVGPACIPHITLPFKETVQGWFENFVPGWDCLMNPGFNFECGAAALEVPMTKAVGTVVKAGKKIADKILDAKKAKKADEAKPKEGSKSPDCESNSFTAGTPVLMADGTTKPIEDVKVGDKVLATDPETGETSIETVTAEIVGTGSKNLVEITIDLDGKQGKKTATVTATDGHPFWVPELSEWIDATALQTGQWLQTSAGTHIQITTIERWTTHTTVYNLTVSDKHTYYVLAGDTSVLVHNCGRRPEGPDPDGNIVYRALAKNEDPAKGLTARDPGNVGVTPLSHVAGKKMTPWISTSKNPSVTFDKYNKGHGVVAIDLRRIPLSYVDISTGPFPSSPRHSAYARRDSEVLIWQKVPAGAIVGHWPGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2Y2</accession>
    <name>A0A0F7N2Y2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Delta-6 fatty acid desaturase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_02390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014575.1">
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            <dbReference type="Pfam" id="PF00487"/>
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        <source>
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    <sequence length="350" mass="38723" checksum="D438AA5C02D552BD" modified="2015-07-22" version="1">MPQATVTSAPKGAATVRSSEFTPLLREVKAAGLLRRRRGWYGCSIAVTLLSLAATGVGIHLLGNTWWTLFLAVPAAVFSTRTAFIGHDSGHAQIAGTRKANRALGLFHGNLLIGMSYHWWTDKHNRHHANPNHIDKDPDVGVGALVWTQRQAAQREGFARWLTRHQAALFFPMLLLEGIALKVSSWQDLRRQGKGERRLEALLLGLHVLGYATLLLTAMSPGKAVVFALVQHAVFGLHLGMCFAPNHKGMEMPETGDDDWGHLRRQVLTSRNVRGGAVTDWLMGGLNYQIEHHLFPNMPRPHLRRVQPLVRAHCAALGLPYAQTSAVESYRLALEHMHEVGEPLRAPDVP</sequence>
</entry>
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            <authorList>
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                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH83200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="379" mass="39779" checksum="99CB1C30B1F08264" modified="2015-07-22" version="1">MFRATRHIAVAAACSGALLLAACGGDSTVDDDVDGGAGGTEPTKLSAGYVSAIDQIGLPAGVEAGYFDEQNLNVKLKEPYPTGVDALNALQAGEVDVVQVGTPAIAAAQQGIDLVLVGNYTGSSSQLSIDETMAVVAGGDSGVDGKDLTTLRGKRIGVSEGSINHLYLLGLLEEAGLKAGDIEIVNTEPPDMAVALETGGIDAGIVWDPWPITMTEQVDGAEEVLRGGGYIPFIGYLVTTRAYAEKNPEVIEGFLTARAQTDQWMRENPDDAADSATRWLPGTEKKVAQEAMKHNVKQLDGRFSACNYLALDTLAGLLAEQGNVEKGFDVNKYFQPEPILKVMKDNPDLFADLPPVPDAAAIDGGYTFDRDTAAEACPS</sequence>
</entry>
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    <accession>A0A0F7N3M4</accession>
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    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81402.1"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <dbReference type="PATRIC" id="fig|444103.5.peg.739"/>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="4pyrrol_Mease"/>
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        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
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        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
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        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
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        <property type="entry name" value="CbiE"/>
    </dbReference>
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        <property type="entry name" value="Cbl_synth_CobL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CbiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="6">
        <location>
            <begin position="15"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH81402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="423" mass="42924" checksum="C8CD205BF892E92D" modified="2015-07-22" version="1">MADRVTVIGWDGSPLTEAALGALGAASLVAGAAHHLALPEVPPGAERIRLGSVGLAARRIARHRGTAVVIADGDPGFFGVVRTLRAPEHGLEVEVLPAVSSVAAAFARAGMPWDDAQVVVAHERNLRRAVNVCRAHPKVAVLTSPGAGPAELALLLRDVHRTFVICEELGGAHERVTVLTSDKVAEHVWRDPNVTLVIGGGIGAGAGPTTAGGAAAPAAGGWLAGHDAGYPPPVRGWSLAPAEYGAAPDEGEAPQLRAVQLARLGPRQGDLVWDIGAGSGAAAVEAARFGAAVIAVDRDPGACARASAAARRFGVLLQTVHGTAPGVLNDLPEPDVVRVGGGGAAAVAGCAARRPERIVAHARTRDGAEEIVRALTDAGYAVECSLLQSVDLDPQGPADAGAGAGWRERERTVVFLIAGSRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N452</accession>
    <name>A0A0F7N452_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-phosphate glycerol 3-phosphate acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_11725</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016127.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_11725"/>
    <dbReference type="EnsemblBacteria" id="AKH82791">
        <property type="protein sequence ID" value="AKH82791"/>
        <property type="gene ID" value="AA958_11725"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_11725"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2465"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007060">
        <property type="entry name" value="FtsL/DivIC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04977">
        <property type="entry name" value="DivIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="63"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH82791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="155" mass="17870" checksum="CBD2E0DD19E8A472" modified="2015-07-22" version="1">MARERFSTTTRLKLLGEQAVSRVSERVYRARPPRRSRLTGRAAVLALVVCSLVVALAYPLRQYIAQRAEVAELEREKAQAEQRVEELRDEKSRWNDPEYVRRQAREHLHYVLPGETGYLMRDGTGSARSGEEGEAVDRPWYENLWDGLDAADGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4M6</accession>
    <name>A0A0F7N4M6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aminotransferase DegT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_08860</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the DegT/DnrJ/EryC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015666.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_08860"/>
    <dbReference type="EnsemblBacteria" id="AKH82319">
        <property type="protein sequence ID" value="AKH82319"/>
        <property type="gene ID" value="AA958_08860"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_08860"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1866"/>
    <dbReference type="OrthoDB" id="1006364at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00616">
        <property type="entry name" value="AHBA_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000653">
        <property type="entry name" value="DegT/StrS_aminotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30244">
        <property type="entry name" value="PTHR30244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01041">
        <property type="entry name" value="DegT_DnrJ_EryC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000390">
        <property type="entry name" value="PLP_StrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000390-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000390-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH82319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="396" mass="42633" checksum="53163CCFE5E6DD61" modified="2015-07-22" version="1">MALTHSEAAAPPVPFFSQARSFTELWPQISDHVNAVFDRGKYSHGRQVGQLERAVAEYTGARHALGVNSGTDALVLLLRAAGIGPGDEVIVPAFTFFATASSVTMAGARPVFADITADGDYALDAGSAEALVTERTKAVMPVHLFHQLAAMDRLTELARRHDLKLLEDSAEGIGMRWDGVHAGLLGAGGVLSFFPTKTLGALGDAGMILTDDDDIAQQAAILRHHGRMGKTLDHIAGISNLSGVSGTNSKMDDVQAAVLLAKLTRLDADIARRRELAAAYDERLRGQEGIHSLPRLVPRPAQADPVFYVYLIEVEKRDELVEFLTARGIGTETYYPRPLHLQPCYAGPEHPEGSLPVAERTCKRTLALPFYPDLTEDQVDIVCGAVADFYAGGADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4Y0</accession>
    <name>A0A0F7N4Y0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_09570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015778.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH82434">
        <property type="protein sequence ID" value="AKH82434"/>
        <property type="gene ID" value="AA958_09570"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_09570"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2017"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519126" evidence="1">
        <location>
            <begin position="26"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="103" mass="10228" checksum="A0AE8A5C37F92298" modified="2015-07-22" version="1">MKYVKSAVVLCGAALALGTAGQAGAIDPGLTSPDLSLDAAAQQAVEGLVNRPPTELVQHNLPVDGPAVRELTRPVGEAAHDVIQGALPQNALAPAGAESRGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N574</accession>
    <name>A0A0F7N574_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_13950</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016484.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH83156">
        <property type="protein sequence ID" value="AKH83156"/>
        <property type="gene ID" value="AA958_13950"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_13950"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2936"/>
    <dbReference type="OrthoDB" id="1437290at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011075">
        <property type="entry name" value="TetR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16859">
        <property type="entry name" value="TetR_C_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="19"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH83156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="204" mass="21459" checksum="7037C219EB65A94B" modified="2015-07-22" version="1">MKPEPDPDPGTLRPGGRTARVRAAVLRATGDALAEQGFAHLDLADVARRAEVGKTTVYRRWGSATGLVADLLAEMAEQSVPRTETGTLLGDLRANARLVLGTLTDPRQGALFRAVIAAATCDDRAAAALHRFYAIRIAEWAPCVEQAVARGELPAGTDPHEVIRAVSAPLYYRLLASGDPLDPAAADRAAEAAAVAAREGAYVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5I9</accession>
    <name>A0A0F7N5I9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UPF0301 protein AA958_10945</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_10945</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the UPF0301 (AlgH) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015997.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_10945"/>
    <dbReference type="EnsemblBacteria" id="AKH82658">
        <property type="protein sequence ID" value="AKH82658"/>
        <property type="gene ID" value="AA958_10945"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_10945"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2302"/>
    <dbReference type="OrthoDB" id="1736059at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00758">
        <property type="entry name" value="UPF0301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003774">
        <property type="entry name" value="UPF0301"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30327">
        <property type="entry name" value="PTHR30327"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02622">
        <property type="entry name" value="DUF179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH82658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="193" mass="20139" checksum="61ACC2929F3C98B4" modified="2015-07-22" version="1">MTEVSSLTGRLLVATPALTDPNFTRTVVLLLDHDDEGSLGVVLNRPTPVGVGDVLRDWADLAGDPGVVFQGGPVSLDSALGLAVVPGDKGGVPGGEGPLGWRRVHGAIGLVDLDAPPELLAAELGTLRIFAGYAGWGPGQLEEELDDGAWYVVESEPGDVSSPAPEGLWRAVLRRQRSELAMVATYPDDPSLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N677</accession>
    <name>A0A0F7N677_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Penicillin amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_12360</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="5">Binds 1 Ca(2+) ion per dimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S45 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016228.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_12360"/>
    <dbReference type="EnsemblBacteria" id="AKH82893">
        <property type="protein sequence ID" value="AKH82893"/>
        <property type="gene ID" value="AA958_12360"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_12360"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2597"/>
    <dbReference type="OrthoDB" id="186419at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.439.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014395">
        <property type="entry name" value="Pen/GL7ACA/AHL_acylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043147">
        <property type="entry name" value="Penicillin_amidase_A-knob"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023343">
        <property type="entry name" value="Penicillin_amidase_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043146">
        <property type="entry name" value="Penicillin_amidase_N_B-knob"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002692">
        <property type="entry name" value="S45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34218">
        <property type="entry name" value="PTHR34218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01804">
        <property type="entry name" value="Penicil_amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001227">
        <property type="entry name" value="Pen_acylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0865">Zymogen</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="16"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="429"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="299"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="377"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="380"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001227-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001227-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH82893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="901" mass="99074" checksum="E0918F4C62CDF7EB" modified="2015-07-22" version="1">MPVNENGRTAGKRRRFIFVAIGLATLLVLGVGAAAFWTVSTVRDSFPQTTGSLKLPGLASPVTVKRDARGVPTLYGDSAEDLFRAQGFVHAQDRFWEMDVRRHMTSGRLSEMFGKDQVETDEFLRTLGWRQVAQKEYDEELSGETKKYLRAYADGVNAYLADHSGSSLSVEYAALGFVNDYEPEKWTPVDSVAWLKAMAWDLRANVEDEIDRSLLSQRFDEGEIADLYPPYPYKRNKPIVEGGTATTGGYEPQSAGGAQGVENTYSTASEGLRSQMGSLAQTMDDIPALLGPSGSGIGSNSWVVSGDLTTTEKPLLANDPHLSAQLPSVWYQMGLQCTRVSDECPYEVSGFSFSGMPGVVIGHNADISWGLTNLGADVADLYLEKVEDDGYLYDGKTREFGTREELIKVAGGEDKRITVRTTRNGPVISDRSDDMAEVGKEAPVGNSAPDRGDGYAVSLRWTALEPSSTMDAVFGINKAADFEEFRQAARDFAVPSQNLVYADTDGNIGYQAPGRIPQRGSGDGSLPAPGWNPAYSWDGYIPFDALPWELNPDRGYIVTANQAVVDEKDYPYLLTTDPGYGARSHRISGLIEEKIEDGGKISPDDMRTMQLDNHSEIAELLTPLLLEIEIDDPMVREAQDLLKDWDYSQDTDSSAAAYFNAVWRNILKLSFGDKMPKELRPDGECLHVPPANPAANPDGPATVRECGERDADAAQPDGGDRWYEVVRSILKDEDNRWWKTTGSDGEPLDENRDELFEHAMNDARWELTAELGKDIDTWSWGRLHRLMLRNQTLGTEGPGVVQWLLNRGPWNLSGGEAAVNATGWNAAGGYDVLWVPSMRMVVDLADLDASGWVNLSGASGHAFHPNYTDQTTAWAKGELYEWAFSDKAVQEAAEDTMTLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6B8</accession>
    <name>A0A0F7N6B8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Large-conductance mechanosensitive channel</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">mscL</name>
        <name evidence="11" type="ORF">AA958_12390</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homopentamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the MscL family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016234.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_12390"/>
    <dbReference type="EnsemblBacteria" id="AKH82899">
        <property type="protein sequence ID" value="AKH82899"/>
        <property type="gene ID" value="AA958_12390"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_12390"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2603"/>
    <dbReference type="OrthoDB" id="1863650at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00115">
        <property type="entry name" value="MscL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001185">
        <property type="entry name" value="MS_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037673">
        <property type="entry name" value="MSC/AndL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036019">
        <property type="entry name" value="MscL_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30266">
        <property type="entry name" value="PTHR30266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01741">
        <property type="entry name" value="MscL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81330">
        <property type="entry name" value="SSF81330"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00220">
        <property type="entry name" value="mscL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="89"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AKH82899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="170" mass="18029" checksum="C5D283118091B83A" modified="2015-07-22" version="1">MSTQDAGSTSESQGVIAGFKQFLMRGNVMELAVAVVVGAAFTSIVNAVVKGVINPIVGVFGSKNLDKYHSCFSDVCTTSPEGEVTKGIAILWGPVLSATLTFVMTAAVVYFAMILPMNKLRERQAAKAPVAETPAEATEIELLTQIRDELVAQRNGETPNREGGTLPTPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6G5</accession>
    <name>A0A0F7N6G5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_12640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016269.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_12640"/>
    <dbReference type="EnsemblBacteria" id="AKH82934">
        <property type="protein sequence ID" value="AKH82934"/>
        <property type="gene ID" value="AA958_12640"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_12640"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2656"/>
    <dbReference type="OrthoDB" id="1896620at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH82934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="211" mass="23193" checksum="34DF5698104B05AD" modified="2015-07-22" version="1">MPFHPCTRGHAQRTSAAAPSLLCAPCIRQAGRHLRELAGLHRECLYQASPTVATRWSNPTKVSTSRRLDYPDISVLDTRQRISSLLESWSRTVVEKRRAAAPKRSVPHLAVFLAGQLDWISAQPAAADFADEVEALVKELRQTIDPELGGHFTFVGECVQDGCGGTITASLRPGEPVPVRSIACSGGHTWAPHEWLLLKQLMERQRKGSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N702</accession>
    <name>A0A0F7N702_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_21585</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_21585"/>
    <dbReference type="EnsemblBacteria" id="AKH84360">
        <property type="protein sequence ID" value="AKH84360"/>
        <property type="gene ID" value="AA958_21585"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_21585"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4545"/>
    <dbReference type="OrthoDB" id="1437290at2"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
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        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039536">
        <property type="entry name" value="TetR_C_Proteobacteria"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14246">
        <property type="entry name" value="TetR_C_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="14"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH84360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="212" mass="23202" checksum="3B2566E8FCA344C3" modified="2015-07-22" version="1">MTAQPSEYHRRVAAQKRTSIIEAATKLFLDSGYDGTSLARIAEAAGVSRATLFKQFTTKAALFEAIVTEYWKVDDGEAPLPEPGNLRAGLETIGRRYVALLTQPGMAALFRIVIAEVPRFPELGETQFKLGKMPYFESVRRYLAAENAAGTARLDDAEMAATQFLGMISNYVFWPRMLLARWEPDDSALSNAVDQAVLTMLARYGAPGAGGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N715</accession>
    <name>A0A0F7N715_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_18395</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017149.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_18395"/>
    <dbReference type="EnsemblBacteria" id="AKH83851">
        <property type="protein sequence ID" value="AKH83851"/>
        <property type="gene ID" value="AA958_18395"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_18395"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3862"/>
    <dbReference type="OrthoDB" id="1797476at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519269" evidence="3">
        <location>
            <begin position="29"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH83851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="246" mass="26115" checksum="64B204711CF401C1" modified="2015-07-22" version="1">MRGRGRGVAGLVAGLVLALGPGAGQAAAEDAETQAGYLAERLRENPVYISDQVPLAVPRSATGEFAKTADRTGVPTYVLVLPNAPAFAEQLLAAVHDRLGEDGLYVLIDAGMSWIDATSYGVDVPVQDARSVVTYEMPFDAWPIESFALFVEALTSDDVAERAQAAREKYGGGPDGRSPTATPEPLHRTPPPEEPESTDDVSVTDRENQSFVTGISLAGVPLLILLVGAYVRRLRRLPHASGPGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N747</accession>
    <name>A0A0F7N747_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_14355</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016535.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_14355"/>
    <dbReference type="EnsemblBacteria" id="AKH83219">
        <property type="protein sequence ID" value="AKH83219"/>
        <property type="gene ID" value="AA958_14355"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_14355"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3021"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="T2SS_GspF_dom"/>
    </dbReference>
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        <property type="entry name" value="T2SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="252"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="7">
        <location>
            <begin position="121"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH83219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="285" mass="28199" checksum="5E824D9BBD366687" modified="2015-07-22" version="1">MSGEAAAVAPVCGAALCAGAAVVLAGGRRPAVRRARALLGPPGSAVRVGRRWRVAAVVRTWGGRRELWCLPAGCVVGLLGASWLPLLAGVVAVPLVGRRLRGRERRGAEVRRAAAVIELCAAVAGGLRAGRQPAGALLAAAPGGPAGGPEVLAAARFGGDVPGALRSAAGAPGAQGLAGVAACWQVAAGGGAGLADGLDRVAAALRAERDERDEVQAQLAGPRATALLLALLPCFGLLMGSALGAAPLRVLLHTPAGLVCLVAGGLLEWAGLAWVGRIVRGAHAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N758</accession>
    <name>A0A0F7N758_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NUDIX hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_14420</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Nudix hydrolase family. PCD1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016545.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_14420"/>
    <dbReference type="EnsemblBacteria" id="AKH83229">
        <property type="protein sequence ID" value="AKH83229"/>
        <property type="gene ID" value="AA958_14420"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_14420"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3035"/>
    <dbReference type="OrthoDB" id="1623169at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010945">
        <property type="term" value="F:CoA pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009132">
        <property type="term" value="P:nucleoside diphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03426">
        <property type="entry name" value="CoAse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045121">
        <property type="entry name" value="CoAse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000059">
        <property type="entry name" value="NUDIX_hydrolase_NudL_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992">
        <property type="entry name" value="PTHR12992"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01293">
        <property type="entry name" value="NUDIX_COA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="5">
        <location>
            <begin position="37"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="65"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH83229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="220" mass="23366" checksum="32796C28A87D8972" modified="2015-07-22" version="1">MAVSDAGLPGWLAPVAEAARTVRPEELSSFLPPDGDGGRPAAVLVLFGDGDDGPELLLTERASSLRSHAGQPSFPGGSLDPEDGDPEGEGPLRAALREAQEETGLDPAGVQVFSVLPRLYIPVSGFVVSPVLGWWREPSPVGVVDPAETARVFSVPVADLTDPANRAMAVHPRGHLGPAFLVCSALVWGFTAGVIDRILHLAGWERPWDRDRRVPLDWHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N776</accession>
    <name>A0A0F7N776_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_10965</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="2"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016000.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_10965"/>
    <dbReference type="EnsemblBacteria" id="AKH82662">
        <property type="protein sequence ID" value="AKH82662"/>
        <property type="gene ID" value="AA958_10965"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_10965"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2308"/>
    <dbReference type="OrthoDB" id="114076at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027785">
        <property type="entry name" value="UvrD-like_helicase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13538">
        <property type="entry name" value="UvrD_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="7">
        <location>
            <begin position="226"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="247"/>
            <end position="254"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH82662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="762" mass="82494" checksum="30D3535DB62644D4" modified="2015-07-22" version="1">MTAHITAPDSVRDREIQAEQEHLDRVYDRLEEKIHEAEFLMSDAAKRGQVGTPGALAERDAQVFRAGVHLNRLNSEFEDFLFGRIDLLPGKDGVRGPDGAYTSVEPADDAVSPSGAGGEQRARIAETLHIGRLGVLDADYAPLVIDWRAPAAAPFYRATPVAPGRVVRRRVIRSKGRRVLGVEDDLLRPELSVTLEGAALPVVGDGALMAALGRARTHAMRDIVSSIQAEQDTVIRAPAASVTEVEGGPGTGKTAVALHRAAYLLYQDRRRYAGGILVVSPTPLLVAYTEGVLPSLGEEGQVAIRAVGSLVEGAEATLYDEPRVARVKGSARMVRVLRRAARGALTAGEVPQRLRVVAFGARVELDARDLRRVRQAVLGGTAPVNLLRARARRFLLDALWQKSGARPRYDDPELAAEARAGFDEDISTEDDFLAFLDAWWPELTPRVVLAALADERRLAGFARRVLNPGEVRGLARSLARDGLTVHDVALLDELQVLLGAPAKPARPRELDPLDQLTGLEELTTYGERTAPAVRRRDEERQEYAHVIVDEAQDLTPMQWRMVGRRGRHATWTVVGDPAQSSWPDPEEAAAARTEALGSRPRRRFTLTVNYRNPAEIAEVASRVLALAMPGTEPPEAVRSTGVVPAFAAAGADPYDTVRAEVGRLLADVDGTVGVVVPMGRREEARARLAELGERVVVLGSLEAKGLEYDATVVLSPAEMADESPAGLRVLYVALTRATQRLTVVSTAPDLPDADGVPDLLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7G3</accession>
    <name>A0A0F7N7G3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine/threonine protein phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_22645</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017793.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_22645"/>
    <dbReference type="EnsemblBacteria" id="AKH84535">
        <property type="protein sequence ID" value="AKH84535"/>
        <property type="gene ID" value="AA958_22645"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_22645"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4764"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="332"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH84535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="673" mass="71265" checksum="876900F564C28DB5" modified="2015-07-22" version="1">MTERDRRRAAAERTESGNTLAAAGTDGAVSPTPPTANSGEAIPDPRDALHRAKPAQPAKAPGAAAGGVPAHQGADDTPSGGRPRPQPGADGDADPAPGMGRPEEDAASARLRFLGAATRRIARGIDLDEIVLGLCRSVVPSFADAILVYLRDPLPVGDEQPTEPFRLRLRRTDRITDGVEDVDSMGGSRLLPAAAEPDAPGLGAAEQVDVVRAGALLEVLRGVRPVFGETLAARAALIELLGRESPLANAPADKRTIVAPLRGRRRVIGVAVLVRGPARPAYGQDDLLIAAQLATHTALGVDKAVIYDREAYIADQLQRTMLPEYLPEPTGVRLASRYRPAAETARVGGDWYDAIPLPGSRVALVVGDVMGHSVTSAAIMGQLRTAAQTLAQLDLPPQEVLHHLDEQAQRLGDDRMATCLYAVYDPIAHTLTASNAGHPPPVLLRRDGFSEVLDVPPGAPIGVGGVGFEAVELQAPQGSTLLLYTDGLVESRLMDVSTGIDQLCARLTRTAALTGPGNPPPLEPLCDEVLDVLGPGDRDDDIALLAARLDGIAPSAAAQWSLDPRAQAPREARSLARGALAGWGLEELTDIVELLVSEVVTNAVRYAQRPVTLRLVHTDRLRCEVVDDVPQLPRMRRAGPADEGGRGMFLVNKLARHWGAERLSVGKVVWFEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7I4</accession>
    <name>A0A0F7N7I4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AA958_11890</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016153.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_11890"/>
    <dbReference type="EnsemblBacteria" id="AKH82817">
        <property type="protein sequence ID" value="AKH82817"/>
        <property type="gene ID" value="AA958_11890"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_11890"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2500"/>
    <dbReference type="OrthoDB" id="856767at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519145" evidence="8">
        <location>
            <begin position="40"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="271"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="320"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="366"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="413"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="444"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="498"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="738"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="784"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="824"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="10">
        <location>
            <begin position="19"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="9">
        <location>
            <begin position="301"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="10">
        <location>
            <begin position="499"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="9">
        <location>
            <begin position="763"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AKH82817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="861" mass="90399" checksum="D9A37101039C2235" modified="2015-07-22" version="1">MTVFKTSMRNFFSHKGRMALSAVAVVLSVAFVCGTLVFSDTMTTTFDRLFKASASDVRVSPKAADNDDGEWGRKPQPTMPAADLKRVEKVDGVKAADGEVANDAITVADADNDNLGSTTGAPTIGTNWDRLELETAEITSGHEPRGPNEVVIDADAADKHGVEIGDEIRTIAAPGSFTSEVVGIATFKITNPGATIVYFDTATAQEKLLGKPGVFSSVNLTAEAGVSNEELRAEVRKAVADSAEPLKVQTKDEVVEENKNDLGSFMDVMKYAMLGFAGIAVLVGIFLIVNTFSMLVAQRTRELGLLRAIGSSRRQVNRSVLVEALLLGVIGSVLGVGAGIGIAVGLMKLMGAVGMELNTADLTINATTPVVGIVLGVVVTVLAAWLPARRAGKVSPMAALREAGTPGDRKAGAVRTALGVLLTAGGGGLLFLTTRVEEAADGAMYLAGGVLLSLLGFIVFAPVLAGLLVRALAAGVLRIFGPVGRMAERNALRNPRRTGATASALMIGLSLVACLSVVGSSMVASATEELDKSVGADFIIQADMGQPIVPEAAKVLDGAPHMEHVTHYKALDADLTLPDGETVEEYSLTAASATYAQDLRTETVRGDLADAYKRDSMSLGEDFAKDHGLKLGDTLTVDFADGGTAELTLRAVTSSETTLDSGAAYLNLTTARDYIKAGDLPFDDIMFGKAKEGQEEAAYASLKELMDPYPQYQVRDQTDFKQTLKDQVGQMLNLVNGLLALAIIVAVLGVVNTLALSVVERTREIGLVRAIGLSRRQLRRMIRLESVVIALFGALLGLGLGLAWGTAAQQLLALEGLKVLDIPWPTIGVVFAGSAVVGLFAALVPAFRAGRMNVLNAIATE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7I8</accession>
    <name>A0A0F7N7I8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_11920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016158.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_11920"/>
    <dbReference type="EnsemblBacteria" id="AKH82822">
        <property type="protein sequence ID" value="AKH82822"/>
        <property type="gene ID" value="AA958_11920"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_11920"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2507"/>
    <dbReference type="OrthoDB" id="1935149at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH82822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="85" mass="9781" checksum="6E18CABE5D5F0EC3" modified="2015-07-22" version="1">MTSRWASLRAGLEEFYAGPYRRTFARARREEDDLFRMVVLAEALGVPDPAAYYTAELVPALYEDFHAWHRRMGMDRSPLGHVGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7K9</accession>
    <name>A0A0F7N7K9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chemical-damaging agent resistance protein C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_19695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017323.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_19695"/>
    <dbReference type="EnsemblBacteria" id="AKH84031">
        <property type="protein sequence ID" value="AKH84031"/>
        <property type="gene ID" value="AA958_19695"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_19695"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4150"/>
    <dbReference type="OrthoDB" id="1437267at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd06974">
        <property type="entry name" value="TerD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003325">
        <property type="entry name" value="TerD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02342">
        <property type="entry name" value="TerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TerD" evidence="1">
        <location>
            <begin position="1"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="191" mass="20379" checksum="8B8F789AF797049C" modified="2015-07-22" version="1">MPVSLSKGGNVSLTKEAPGLTAVTVGLGWDVRTTTGVDFDLDASAIAVNAEGRVFSDQHFIFFNNRQSPDQTIVHTGDNVTGEGAGDDEQINVNLVGLPPEIDKIVFPVSIYDAETRSQNFGQVRNAFIRVVNQAGGTEIARYDLSEDAATETAMVFGELYRNGAEWKFRAVGQGYASGLSGIAQDFGVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7M1</accession>
    <name>A0A0F7N7M1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Glutamate decarboxylase</fullName>
            <ecNumber evidence="3 7">4.1.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_15575</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>H(+) + L-glutamate = 4-aminobutanoate + CO2</text>
            <dbReference type="Rhea" id="RHEA:17785"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:59888"/>
            <dbReference type="EC" id="4.1.1.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 5 6">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the group II decarboxylase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.15" evidence="3 7"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016705.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_15575"/>
    <dbReference type="EnsemblBacteria" id="AKH83393">
        <property type="protein sequence ID" value="AKH83393"/>
        <property type="gene ID" value="AA958_15575"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_15575"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3278"/>
    <dbReference type="OrthoDB" id="1478871at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004351">
        <property type="term" value="F:glutamate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006536">
        <property type="term" value="P:glutamate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010107">
        <property type="entry name" value="Glutamate_decarboxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43321">
        <property type="entry name" value="PTHR43321"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01788">
        <property type="entry name" value="Glu-decarb-GAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="4 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="5">
        <location>
            <position position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH83393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="460" mass="50964" checksum="7FA7712142ED0CC9" modified="2015-07-22" version="1">MALHQTERGVAGPYDDVYAMPISEHALPKYFMPEEVSDPRAVNALIRDELALDGNAAQNLATFCTTWAEDEVHSLMDECIGKNMVDKDEYPQTADIENRCVHILADLWHSPHGETTMGCSTTGSSEAAMLGGLALKWRWRTRRKAEGKPADRPNLVCGPVQVCWEKFARYFDVELRQVPLEPDATGLRPHQLREYVDENTIGVVAILGVTYTCDYEPVKEIAAELDAIQADTGLDVPVHVDAASGGFVAPFLRPELEWDFRVERVASINSSGHKYGMAPLGVGWAIWRSADLLPEDLIFRVSYLGGDMPTFALNFSRPGGEVVAQYYNLLRLGRAGYRRIYRAAAGSAEWLGEQIAGMGPFTLLYDGRGALPAVSWTLTDPAGAGFTLYDVTEQLRLRGWQVPAYPLPPRRQETVIQRVLIRHGISHDKIELLAADVREALDRLKDGAGTPAPQQPAFHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N818</accession>
    <name>A0A0F7N818_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_23825</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017987.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_23825"/>
    <dbReference type="EnsemblBacteria" id="AKH84735">
        <property type="protein sequence ID" value="AKH84735"/>
        <property type="gene ID" value="AA958_23825"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_23825"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5021"/>
    <dbReference type="OrthoDB" id="1523519at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071705">
        <property type="term" value="P:nitrogen compound transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010065">
        <property type="entry name" value="AA_ABC_transptr_permease_3TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01726">
        <property type="entry name" value="HEQRo_perm_3TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="266"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="84"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH84735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="322" mass="35484" checksum="F4228CA38510E507" modified="2015-07-22" version="1">MTDPTSPGPADKRPAGPDLAKTGTATAVPPEAIKAIPVRHPWRWVSAAVVLALLGLLVYAFANAKIEWGDVPEYLFSDRVVEAAGNTLLITVLAMLLGVVLGIVLAIMRLSDNPVTSAFANLYIWFFRGTPVLLQLLLWYNLGLVFQTLNLGPLYKNEMTDVMTPFVAALLGLGLNEAAYMAEIVRAGIQSVDEGQTEASHALGMSRGKTMRRIVLPQAMRVIVPPTGNEFINMLKTSSLAMVIQYTELTFVANEISATNLNPMEMYIVVAIWYLAMTSVFSVIQYYIERHYAKGSVRQLPLTPWQKIRRSIFSGPRLKGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N854</accession>
    <name>A0A0F7N854_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">2-oxoglutarate ferredoxin oxidoreductase subunit alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_20710</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017497.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_20710"/>
    <dbReference type="EnsemblBacteria" id="AKH84211">
        <property type="protein sequence ID" value="AKH84211"/>
        <property type="gene ID" value="AA958_20710"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_20710"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4368"/>
    <dbReference type="OrthoDB" id="360732at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016903">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07034">
        <property type="entry name" value="TPP_PYR_PFOR_IOR-alpha_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.920.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022367">
        <property type="entry name" value="2-oxoacid/accept_OxRdtase_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033412">
        <property type="entry name" value="PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019752">
        <property type="entry name" value="Pyrv/ketoisovalerate_OxRed_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002880">
        <property type="entry name" value="Pyrv_Fd/Flavodoxin_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002869">
        <property type="entry name" value="Pyrv_flavodox_OxRed_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17147">
        <property type="entry name" value="PFOR_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01558">
        <property type="entry name" value="POR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01855">
        <property type="entry name" value="POR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53323">
        <property type="entry name" value="SSF53323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03710">
        <property type="entry name" value="OAFO_sf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POR" evidence="2">
        <location>
            <begin position="24"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="POR_N" evidence="3">
        <location>
            <begin position="265"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="PFOR_II" evidence="4">
        <location>
            <begin position="527"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH84211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="629" mass="67211" checksum="D4D25783EFE83DAD" modified="2015-07-22" version="1">MTSEVNSKEVKRLDRVIIRFAGDSGDGMQLTGDRFTSETASFGNDLSTLPNFPAEIRAPAGTLPGVSSFQVHFADHDILTPGDAPNVLVAMNPAALKANIGDVPRGAEVIVNTDEFNKRAMAKVGYEASPLEDGSLDGYSVHEVPLTTLTVEALKEYGLSRKDAGRSKNMFALGLLSWMYHRPTEGTIGFLRAKFAKKPDIAEANIAAFRAGWNFGETTEDFAVSYEVAPAQSAFPAGTYRSISGNLALAYGLIAAGQQADLPLFLGSYPITPASDILHELSRHKNFGVRTFQAEDEIAGIGAALGAAFGGALGVTTTSGPGVALKAETVGLAVSLELPLLIVDIQRGGPSTGLPTKTEQADLLQAMFGRNGEAPVPIVAPATPSDCFTAALDAARIALTYRTPVMLLSDGYLANGSEPWRIPEVDDLPDLRVQFASKTNHTLADGTEVFWPYKRDPQTLARPWAIPGTPGLEHRIGGIEKEDGSGNISYSPSNHDLMVRTRQAKVDGIEVPDIEVDDPEGPSGERARTLVLGWGSTYGPITAAVRRVRRAGDHIAQAHLRYLNPFPGNLGEVLAAYDKVIVPEMNLGQLATLVRARYLVDAFSYNQVNGMPFKAEQLATALKEAIDNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N878</accession>
    <name>A0A0F7N878_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">LuxR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_20885</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017526.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH84241">
        <property type="protein sequence ID" value="AKH84241"/>
        <property type="gene ID" value="AA958_20885"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_20885"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4402"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03704">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="BTAD" evidence="3">
        <location>
            <begin position="94"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="909"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="909"/>
            <end position="926"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH84241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="1075" mass="112767" checksum="3E6A5D92F44915C4" modified="2015-07-22" version="1">MTGRVELTFLSRVAFRGREITAPRVRGLLALLAGELRGGCSVGRLVDGLWGEELPADPANALRILASRARAQVGADVVVSTPTGYRLALAPEQVDTAAVERCAEDAARAVRAGDHAAALAAAEEGLGYWDAPPEAEGLPGDPVAELRAEHAAAYADLVRARALALARTGRRAEAAAPLARLHAGAPRDEEVLAELLRAEAASAGPAAALARYDAYRRRLRDGLGTDPGAGLKAVHQELLRAGAPAVRHGVPHDPNPLLGRDADLAAVGALLRSSRLTSIVGPGGLGKTRLAYAVSRRAEQQLVHVVSLAGVRADEDVAGEVASAVGGGSGTPGADVHATLVAALGGQPALLVLDNCEQVVHGAADLVRALLTSAADLRVLVTSRAPLGLSSEAVHHLPQLTPETSAELFAQRARAARPDAELPPAAVAELCQHLDGLPLAVELAAARVRVLSVPEIARRLGDRFALLRGGSRDAPERHRTLHAVVEWSWNLLEEDARGALRALSVFPGGFTAQAAEQLLTSGDALELLEQLVDQSLLKAADTAAGIRFHMLETVREFSAARRAAAGEDEAVTARFLGWARDFGVAHHDALFGREPLQHWPRLRAEQDNLVLALRYALARGDHATTAAAGAVLAGVWITDSASFHRTFGLAADTARPLSHYRPDPRHTEVTRTLCALATAAPFMGYGPLHPRHLATLRRLPPAEPDTLLRALAVVLCAAPGMRPPGYGALDELRASDAPLLAGIAECVASYLLEHAHEPERALAAARRVLAAVDAVPNPSLGLLGHSRCSELCMEAGMGEEAYGHLLAALEALAHLGDQSPTTGLRRGLVLACLQRGEPDEAAMWLRRVEEERSAAEQPQLLAGYEAAWGEIALSRGLTELGLKHWRTAVDKLRPGGPREATYPPVAVPVALSTPPDEGPPGDRPDAPPADPLDDSWGLHVAAAAVAAHAYAGRLEPVADLVALLERRIRALLLAGPLPATEVPAEAGVDGTAVLCLGLVRLAAGDTSAVRLVALAERLYVPQAFHPTLSVDRARRAAQDADGAAYADAVSEYAALGRSELREVARGLIAPPSGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N898</accession>
    <name>A0A0F7N898_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Peptide ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_17325</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016982.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_17325"/>
    <dbReference type="EnsemblBacteria" id="AKH83678">
        <property type="protein sequence ID" value="AKH83678"/>
        <property type="gene ID" value="AA958_17325"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_17325"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3643"/>
    <dbReference type="OrthoDB" id="1479518at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="127"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="227"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="276"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="95"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH83678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="308" mass="32666" checksum="B8AD8B740DC4F381" modified="2015-07-22" version="1">MGAFLAKRLAQAVVVAFGALTLVFLIVRVVPGDPAKLIVGPDASAGQLESVRADFGLDDPLWRQYADHLAGIVRGDLGDSWRLGGSALSNTLDRFPATLSLSLAALLFTVAVGIPLGMLCARRPGKLLDLVVSTGSLAGQAIPSFWLGIVLILVFARRLDWLPATVDGSPTAVLLPAFTLSLPFIGWLARLVRSSALEEGAKDYARTARAKGVGEGTIQYVHVGRNIAIPVVTVLGLLMGNFIANAVIIEVVFSWPGIGSLMVDAITNRDYAVVEAAILTITLAYIVLNLLVDVVYFVIDPRLTPEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8A5</accession>
    <name>A0A0F7N8A5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7 8">Elongation factor Tu</fullName>
            <shortName evidence="7">EF-Tu</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">tuf</name>
        <name evidence="10" type="ORF">AA958_21085</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_027771071.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_21085"/>
    <dbReference type="EnsemblBacteria" id="AKH84271">
        <property type="protein sequence ID" value="AKH84271"/>
        <property type="gene ID" value="AA958_21085"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_21085"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4440"/>
    <dbReference type="OrthoDB" id="621774at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01884">
        <property type="entry name" value="EF_Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03697">
        <property type="entry name" value="EFTU_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00118_B">
        <property type="entry name" value="EF_Tu_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041709">
        <property type="entry name" value="EF-Tu_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033720">
        <property type="entry name" value="EFTU_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004541">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_bac/org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004160">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03143">
        <property type="entry name" value="GTP_EFTU_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="SSF50465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00485">
        <property type="entry name" value="EF-Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7 10" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="5 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="9">
        <location>
            <begin position="10"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="19"/>
            <end position="26"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="83"/>
            <end position="87"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="138"/>
            <end position="141"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AKH84271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="397" mass="43891" checksum="3B729200A5A53714" modified="2015-07-22" version="1">MAKAKFERTKPHVNIGTIGHIDHGKTTLTAAITKVLHDAYPDLNEASAFDQIDKAPEEKQRGITISIAHVEYQTESRHYAHVDCPGHADYIKNMITGAAQMDGAILVVAATDGPMPQTKEHVLLARQVGVPYIVVALNKADMVDDEEIMELVELEVRELLSEYEFPGDDVPVVKVSALKALEGDAEWGKTVLDLMKAVDESIPEPVREIDKPFLMPIEDVFTITGRGTVVTGRIERGILKVNEEVEIIGIKEEKTKTTVTGIEMFRKLLDEGQAGENVGLLLRGIKREDVERGQVIIKPGTVTPHTEFEATAYILSKDEGGRHTPFFNNYRPQFYFRTTDVTGVVHLPEGTEMVMPGDNTDMKVELIQPIAMEEGLKFAIREGGRTVGAGQVTKILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-12-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8P4</accession>
    <name>A0A0F7N8P4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_18520</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH83868">
        <property type="protein sequence ID" value="AKH83868"/>
        <property type="gene ID" value="AA958_18520"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_18520"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3887"/>
    <dbReference type="OrthoDB" id="1832218at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="PTHR21240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="2">
        <location>
            <begin position="25"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH83868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="302" mass="33479" checksum="CB0A27AA5A2A9C93" modified="2015-07-22" version="1">MTSAGNAERDRVAEFRRALGLEHLIDVHTHFMPQRVLAKVWAYFDAAGPLVGRPWPIMYRQEEAERVALLRGFGVRAFTSMLYPHKPGMARWLNDWSADFAARTPDCLHTATFFAEPGAADDVRRAVGQGARVFKCHLQVGAYDPNDPVLDEVWSLLADAALPVVTHCGSGPVPGPYTGPAPIAALLKRHPRLRLIVAHLGMPEYEDFLTLAERHEDVMLDTTMAFTAFSESAAPFPPHARPRLAALRDRILLGTDFPNTPYPYAAALDALTTQDQDDDWLRAVCHDNAARLFGLEATRGFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8R4</accession>
    <name>A0A0F7N8R4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Dienelactone hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_22085</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017698.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_22085"/>
    <dbReference type="EnsemblBacteria" id="AKH84436">
        <property type="protein sequence ID" value="AKH84436"/>
        <property type="gene ID" value="AA958_22085"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_22085"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4652"/>
    <dbReference type="OrthoDB" id="1694750at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH84436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="246" mass="25946" checksum="535B4408646C15BF" modified="2015-07-22" version="1">MPQEISASRPARLGRATGAASAQAVALLLPAGEDVSSRRPSRLAAASVWSLARRLGRAGRGDGLVAHTVHYRYRGWNGAAADAAQDAEWALEEIVRRYGDVPVALVGTDVGGRAALRAAGHEAVVSVLAIAPWLPDAQAADAEPVRQLSGRTVLFVHGTDDARTDPDLSYRLAVRAKKANRDVCRFEVHSDGHGLHQHRPEVLALSADFVTGSLFGRPYSRPLADALAAPPPIGLRMPLAAGFAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8Y9</accession>
    <name>A0A0F7N8Y9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Carbohydrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_18670</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017186.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_18670"/>
    <dbReference type="EnsemblBacteria" id="AKH83889">
        <property type="protein sequence ID" value="AKH83889"/>
        <property type="gene ID" value="AA958_18670"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_18670"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3915"/>
    <dbReference type="OrthoDB" id="469334at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018905">
        <property type="entry name" value="A-galactase_NEW3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029483">
        <property type="entry name" value="GH97_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019563">
        <property type="entry name" value="GH97_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029486">
        <property type="entry name" value="GH97_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013222">
        <property type="entry name" value="Glyco_hyd_98_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038637">
        <property type="entry name" value="NPCBM_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14509">
        <property type="entry name" value="GH97_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14508">
        <property type="entry name" value="GH97_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10566">
        <property type="entry name" value="Glyco_hydro_97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08305">
        <property type="entry name" value="NPCBM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10633">
        <property type="entry name" value="NPCBM_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00776">
        <property type="entry name" value="NPCBM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519191" evidence="3">
        <location>
            <begin position="33"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="domain" description="NPCBM" evidence="4">
        <location>
            <begin position="767"/>
            <end position="912"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH83889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="913" mass="96816" checksum="B5786F45D5D1E95B" modified="2015-07-22" version="1">MPLFGPLGRRPAGTMLTAFTVLATAWLSPAAATPVPDSPTPTATTSDVWTVAPPQGNNDQLAADVVRDDATGALTLTVRRGGDEVLPDSPLGLRTKGADLTRGLDVLGRDDRSLRERYEMTTGKQRRVDSPMTESRFALRGDGGVRMDLVVRVARDGVAFRYELPDSEGTVVTGEASGYRLPADAPAWLLPHTSWYEEVRGETTAGGAAADDYGYPALFEVAADDYVLLTESGMDSTYPGSKLAHAGGGAYDVALAEAEVVSPGDLATPWRTAIVGDLATVTESTLVSDLAPDAEFSDTSWIRPGTVSWSWLVEHDSPRDFERQKDYVDYAAAHGWEYTLVDEGWSREWVPELVRYARTKGVDILLWFRWWEVDTPQEMETVFGELNDWGVKGVKVDFMNSGGGEPEGVGRHAWYEDVLAATAEHRLLVNFHGATLPKGLQRTWPHLMTYEAVRGHEYYSFNQPLTPTYNTMLPFTRNVVGSADVTPGTFSMTNRTHSDAHELALPVVYESGLQHPADSPETYATLPEAERVLDQLPTVWDETRYLGGRPGDDAVLARRAGDRWFVGGIHAGAAGTAEVDLGRLGADDGERLLVELVTDGADGLARETRRVGGDARLTVPVAENGGFVAVVCAAENGRSTCDEPVRTTPATGLAITPGSATVSSGDEIEVTGRFAAADGESATLRNVTLGARPRAGWTAAGEDVARPALRPGQAVSGSWTVRVPESAEPGYVDVPVVAEYSAPGAGPAEPRVHVERAVRVLVAPPVPQGEAHVGDLHLLTASNGWGPVEIDTSVGDDGAGDGAPLTIGGTTYAKGLGAHAPSRVTVYLGGACTSFAAQVGVDDEVGDRGSVSFRVLGDGTELTATGTLRGTDAAQSVTADVTGVDLLTLEVADGGDGISYDHADWADPKVTCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N903</accession>
    <name>A0A0F7N903_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_18815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017206.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH83909">
        <property type="protein sequence ID" value="AKH83909"/>
        <property type="gene ID" value="AA958_18815"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_18815"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3951"/>
    <dbReference type="OrthoDB" id="1927012at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="170" mass="18182" checksum="B36CA9990DAB22B9" modified="2015-07-22" version="1">MARALADQIRPGAAPRDVTVSFGVRRQAAAEYHHRSRGGPVTVFAQALHAALYGLPVDDDPLPTALDELLQATHTATSREQRAAVMRRLADQLGNAAEIIQRYQYQAQADRLPDDIATQLSDACGQAQRIAEILDRAAPAFSSPPAAQVPPGPRPRHAAGPPAAPPGHRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N923</accession>
    <name>A0A0F7N923_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_18965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017224.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_18965"/>
    <dbReference type="EnsemblBacteria" id="AKH83929">
        <property type="protein sequence ID" value="AKH83929"/>
        <property type="gene ID" value="AA958_18965"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_18965"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3981"/>
    <dbReference type="OrthoDB" id="260566at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="504" mass="53618" checksum="6D0429CAA397E4FB" modified="2015-07-22" version="1">MNRRSARRAVRASALFTPHGTDRADRKAARRRLAEATAEARAQAGTQQTEPAAATGQAAVALYPTSGRPGPASARNNRLKLPDHHMTTAVAAGAYPFLAEGGLGADGIYIGRDVHAEASFVFDPFELYGKIPGFTNPNLMLAGVIGQGKSAFAKSIALRSVAFGYRVYIPCDPKGEWTAVATALGGRTVALGPGLPGRLNPLDAAARPNGVAEADWAGEIRKRRLLLLGSLARTVLGRDLMPMEHTALDVALDHAVIHAAGARRPPLLGDIAAALTDTGVLDEAGEPGMVSGHLAEAARDLAHAMRRLVHGDLAGMFDAPSTVAFDPNAAMLTIDLSRLGGSGDDTALVLAMTCASAWMEAALADPHGGRRWIIYDEAWRLMRHVGLLQRMQAQWKLSRGLGIANMMIIHRLSDLLTAGDAGSQGRALAEGLLADCSTRIIYRQETDQLHTAATLLGLTSVETDAVSHLGRGRGLWKVADRSFIVQHLLHSRELALFDTDARMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9B3</accession>
    <name>A0A0F7N9B3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GCN5 family acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_19660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017316.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH84024">
        <property type="protein sequence ID" value="AKH84024"/>
        <property type="gene ID" value="AA958_19660"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_19660"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4142"/>
    <dbReference type="OrthoDB" id="1497607at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="167" mass="18576" checksum="996744EA7EB9AA11" modified="2015-07-22" version="1">MIETERLLLRPLTTGDADVDAFVALHADERVNRFVGAYTPEQARTRLAAIERQWAERGHGLCAVELKSSGEFIGRVGLNYWEELDEVELGWTLAAEHWGHGYATEAAGACLEWGFATLAEEYFISLIRPANTASARVAERLGFEARREETFMGHGVAVWVRERPAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9E5</accession>
    <name>A0A0F7N9E5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_23355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017912.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_23355"/>
    <dbReference type="EnsemblBacteria" id="AKH84656">
        <property type="protein sequence ID" value="AKH84656"/>
        <property type="gene ID" value="AA958_23355"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_23355"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4923"/>
    <dbReference type="OrthoDB" id="1196738at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="39"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="286" mass="30308" checksum="9E434A17D295397A" modified="2015-07-22" version="1">MSKPPFVALPGGVEALRVETPRGAFAALRAGRPVHGTALLLPGFTGSKEDFIALLEPLAAAGFRVIAVDGRGQYETEGPGDEDAYTQDELAQDVLALTTALGTADGPPPHLLGHSHGGHVARAAVLRAPGAFSSLTLMSSGPGVVCDEQRSRAKLLGDALATYDLETVWQAMRAFDPPEAADARTPADVNDFLHRRWLGTSPAQLRATARQLCEEPDRTAELAALPLSVHVLTGTSDYVWPVAQMDDMAKRLRAHRTVVDGADHSPNVDRPAETAAALAAFWSADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9R9</accession>
    <name>A0A0F7N9R9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_20970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017538.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_20970"/>
    <dbReference type="EnsemblBacteria" id="AKH84253">
        <property type="protein sequence ID" value="AKH84253"/>
        <property type="gene ID" value="AA958_20970"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_20970"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4419"/>
    <dbReference type="OrthoDB" id="1928533at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="SNARE_assoc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="SNARE_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="197" mass="21050" checksum="7CD712D444F4FBC8" modified="2015-07-22" version="1">MEDLGAPGAGLAIALENLFPPLPSEVILPLAGFTASQGGLNLAAVLVWTTIGSVVGALALYWVGALLGRERTVALAAKLPLLKVRDIERTEAWFLRHGTKAVFFGRMIPIFRSLISVPAGVERMRVPVFLGLTAAGSALWNTVFVLAGYWLGSRWHEISDLVGVYSKVVLGAVALAVVLFFTLRAVTAGHGRHRAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9T4</accession>
    <name>A0A0F7N9T4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_27290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH85320">
        <property type="protein sequence ID" value="AKH85320"/>
        <property type="gene ID" value="AA958_27290"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_27290"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5750"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="126" mass="11977" checksum="BF1183B41941B346" modified="2015-07-22" version="1">MVVAVVLAVAGVLGAGAGQGGGAAVFGGPSPYGAAFDVVGESAPGADQHLADAPGAGPEDHAAPQQGQRGAPAERPCAPFVAVPRPPYDLPRTPSVPAPAPPDGGTLPGFSPAPGGERAPPPVPGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9W8</accession>
    <name>A0A0F7N9W8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Methionine aminopeptidase</fullName>
            <shortName evidence="2">MAP</shortName>
            <shortName evidence="2">MetAP</shortName>
            <ecNumber evidence="2 3">3.4.11.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Peptidase M</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">map</name>
        <name evidence="6" type="ORF">AA958_21285</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 2">Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 3">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="2 3">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="2 3"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017577.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_21285"/>
    <dbReference type="EnsemblBacteria" id="AKH84308">
        <property type="protein sequence ID" value="AKH84308"/>
        <property type="gene ID" value="AA958_21285"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_21285"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4482"/>
    <dbReference type="OrthoDB" id="1285136at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070084">
        <property type="term" value="P:protein initiator methionine removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01086">
        <property type="entry name" value="MetAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01974">
        <property type="entry name" value="MetAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002467">
        <property type="entry name" value="Pept_M24A_MAP1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00500">
        <property type="entry name" value="met_pdase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00680">
        <property type="entry name" value="MAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 6" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519349" description="Methionine aminopeptidase" evidence="4">
        <location>
            <begin position="32"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M24" evidence="5">
        <location>
            <begin position="12"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH84308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="278" mass="29357" checksum="3FE10D4AAA35DF97" modified="2015-07-22" version="1">MVEIKTPEQIAKMRAAGLVVAAMHQACAAAAVPGATTKDLDEIAAKVLADHGAKPNFLGYGGFPGNICTSVNDVVVHGIPDRETVLREGDVISIDAGAIVDGWHADAAITAFVGSGHKAELHELSRVTEESMWAGIAAVRKGNRLVDISAAIEGYIRRQPRPAAGKYGIVEDYGGHGIGSQMHMDPHLLNYVDRRRGRGPKLVPGFCIAIEPMVSLGTPRTHVLADEWTVKTDDGSWSSHWEHSVALTEAGPLVLTAPDGGREKLAAYGITAAPDPLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9X1</accession>
    <name>A0A0F7N9X1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">30S ribosomal protein S4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rpsD</name>
        <name evidence="10" type="ORF">AA958_21310</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="6">With S5 and S12 plays an important role in translational accuracy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017578.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_21310"/>
    <dbReference type="EnsemblBacteria" id="AKH84313">
        <property type="protein sequence ID" value="AKH84313"/>
        <property type="gene ID" value="AA958_21310"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_21310"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4487"/>
    <dbReference type="OrthoDB" id="1211060at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01306_B">
        <property type="entry name" value="Ribosomal_S4_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_S4/S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001912">
        <property type="entry name" value="Ribosomal_S4/S9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005709">
        <property type="entry name" value="Ribosomal_S4_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018079">
        <property type="entry name" value="Ribosomal_S4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="PTHR11831"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831:SF4">
        <property type="entry name" value="PTHR11831:SF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00163">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01390">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01017">
        <property type="entry name" value="rpsD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00632">
        <property type="entry name" value="RIBOSOMAL_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_S4" evidence="9">
        <location>
            <begin position="3"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="S4" evidence="8">
        <location>
            <begin position="98"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AKH84313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="208" mass="23827" checksum="FC0FE494869E22FB" modified="2015-07-22" version="1">MARYTGADCKRCRREKQKLFLKGAKCESAKCPIEIRPYPPGEHGRGRTKDSEYLLQKREKQKCARIYGVLEKQFRGYYNEANRQSGKTGENLLRILETRLDNVVYRAGFAKSRDHARQLVRHGHITVNGRKTDIPSARVVPSDIIEVRESSRNLTPFAVAQAEAGDRTVPAWLEAIPSKLRILVHSLPERQVIDTQVQEQLIVELYSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9X8</accession>
    <name>A0A0F7N9X8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_16255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_16255"/>
    <dbReference type="EnsemblBacteria" id="AKH83502">
        <property type="protein sequence ID" value="AKH83502"/>
        <property type="gene ID" value="AA958_16255"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_16255"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3424"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="135" mass="13054" checksum="682962C985E84579" modified="2015-07-22" version="1">MTVTGGLLTGAGFLWQAAAMDADGAFLSAILGPALPMAAGQAVLLALLTDVSTSGVGERDAGGVSGLVNTSRQIGAVPGLAILGAVASAGHGAPEDGYARAFLAAGLITAASMLLVPFLPRPGKQTRPVSGSVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NA46</accession>
    <name>A0A0F7NA46_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8 9">Uroporphyrinogen decarboxylase</fullName>
            <shortName evidence="8">UPD</shortName>
            <shortName evidence="8">URO-D</shortName>
            <ecNumber evidence="4 8 9">4.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">hemE</name>
        <name evidence="14" type="ORF">AA958_27855</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>4 H(+) + uroporphyrinogen III = 4 CO2 + coproporphyrinogen III</text>
            <dbReference type="Rhea" id="RHEA:19865"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57308"/>
            <dbReference type="ChEBI" id="CHEBI:57309"/>
            <dbReference type="EC" id="4.1.1.37"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8 9">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8 10">Belongs to the uroporphyrinogen decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.37" evidence="4 8 9"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="WP_047018649.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
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    <dbReference type="STRING" id="444103.AA958_27855"/>
    <dbReference type="EnsemblBacteria" id="AKH85415">
        <property type="protein sequence ID" value="AKH85415"/>
        <property type="gene ID" value="AA958_27855"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_27855"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5871"/>
    <dbReference type="OrthoDB" id="1104410at2"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00321"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004853">
        <property type="term" value="F:uroporphyrinogen decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
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        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00717">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="URO_D"/>
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006361">
        <property type="entry name" value="Uroporphyrinogen_deCO2ase_HemE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000257">
        <property type="entry name" value="Uroporphyrinogen_deCOase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01208">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="SSF51726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01464">
        <property type="entry name" value="hemE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00906">
        <property type="entry name" value="UROD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00907">
        <property type="entry name" value="UROD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8 9" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="6 8 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 8 9" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uroporphyrinogen_deCOase" evidence="12">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="Uroporphyrinogen_deCOase" evidence="13">
        <location>
            <begin position="163"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="51"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
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        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
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            <position position="230"/>
        </location>
        <ligand>
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        <location>
            <position position="344"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="8">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
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    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012288"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
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        <source>
            <dbReference type="PROSITE" id="PS00906"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS00907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AKH85415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="368" mass="38649" checksum="7D5140E0EB73DFB3" modified="2015-07-22" version="1">MSADSAPRPSATSTAGAASTATAPAGPAADSAFLRACRREPVPHTPVWFMRQAGRSLPEYRRLREGIAMLDSCRRPDLVTEITLQPVRRHGVDAAILFSDIVVPLKAIGVDLDIKPGVGPVVAQPVRSRADLAQLRPLEPDDVPYVTEAVGRLTEELGATPLIGFAGAPFTLASYLVEGGPSRNHEHTKAMMYGAPELWAELVGRLAGITAAFLRVQIEAGASAVQLFDSWAGALAPADYRRAVLPASAEVFAAVAGYGVPRIHFGVGTGELLTAMGESGADVVGVDWRVPLDEAARRAGPGKALQGNLDPAVLFAPREAMEAKAGEVLQAAAGLEGHVFNLGHGVLPTTDPDALTRLVEYVHESSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAF8</accession>
    <name>A0A0F7NAF8_9ACTN</name>
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        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_28500</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
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    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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    </dbReference>
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        <property type="gene ID" value="AA958_28500"/>
    </dbReference>
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    <dbReference type="PATRIC" id="fig|444103.5.peg.6005"/>
    <dbReference type="OrthoDB" id="1179151at2"/>
    <dbReference type="Proteomes" id="UP000034283">
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
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    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="19"/>
            <end position="259"/>
        </location>
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    <feature type="binding site" evidence="3">
        <location>
            <begin position="51"/>
            <end position="58"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH85530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="273" mass="29282" checksum="12A5311F3C5DD157" modified="2015-07-22" version="1">MTKATDDTAAGSAAGRPLVELADVSKYYGNIRALEGVSLQVHPGEITCVLGDNGAGKSTLIKIISGLHQHDAGSFRIDGRDSRLSNPREALDRGIATVYQDLAVVPLMPVWRNFFLGSEPTLGRGPLRRLDVAKMRATTHAELLRMGIDLRDVDQPIGTLSGGERQSVAIARAIYFGAKVLVLDEPTAALGVKQSGVVLKYVAAARDHGLGVVLITHNPHHAYLVGDRFILLKRGAMAGSHARAGITLDELTRQMAGGSELEQLSHELQREKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAG7</accession>
    <name>A0A0F7NAG7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_22130</name>
    </gene>
    <organism evidence="8 9">
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        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="AKH84444"/>
        <property type="gene ID" value="AA958_22130"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_22130"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4661"/>
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    <dbReference type="Proteomes" id="UP000034283">
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014325">
        <property type="entry name" value="RNA_pol_sigma-E_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02983">
        <property type="entry name" value="SigE-fam_strep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="76"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="7">
        <location>
            <begin position="165"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="236" mass="25439" checksum="8B2074BDB7E51664" modified="2015-07-22" version="1">MVAIAGNTGPGGTGVMPAGTGPAADPGGNAGGDTRGDDGGKKAYGEVPGETAGTQAGAAAEADSTAAFTAYVAERRASLYATAYHLTGDRFEAEDLLQSALFSTYRAWDRISDKAAVGGYLRRTMTNLHISAWRRRKLAEYPTEELPEAPGESDAMRGTELRTVLWQALARLPEMQRTMLVLRYYEGRTDPEIADVLGISVGTVKSSIWRSLRRLRDDEALSFGRDREESFEELVA</sequence>
</entry>
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">CNQ-509</strain>
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="AKH84578.1"/>
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    </evidence>
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            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="134" mass="14411" checksum="E66C00EF8B6BD7DF" modified="2015-07-22" version="1">MRYDRTVHLDTDFTTAVARTRDALAAQGFGILTEIDVTATLKAKLDHDMEDYVILGACNPPLAHRALDTDRSIGLLLPCNVVVRRDGDRIAVQALDPGTMVTLTGLDALRPVAEEATERLDAALAALTAAGRKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
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                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">CNQ-509</strain>
        </source>
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    </dbReference>
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    </dbReference>
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        <location>
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        <location>
            <begin position="100"/>
            <end position="114"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH84663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="502" mass="49965" checksum="776E722005BC7118" modified="2015-07-22" version="1">MTDGPRAAPEPPTRAPSPPTPAEDLAEALEEAFGPRPEPPAVASLHPPPADGEADSPGTGAAEAAGRGTAAPGAQPASSGAASRRAGGAAAAVAGHPGPPRTAQPAPPSAPAAAAAPAVRPRRGSADPVRGLMYRHRELCRRAVDPLEIAAGLEAHGVTDRTAVRCRHRDVFSLAEEMYVRTRRPGAEPPPPGAPLPRTPLAPLAHLLPLGGGLLVLGAAGLHGRAQVALTAAGVAWAVVALVLGSQRGPLRVGAGLPPAAGLAVGWLLAYAVYGDWFLGELLGGATGVTRAPVVPYATAAALAALTAAVLPAAAVARWFSARARGRLRESRDLAEFRTRTRPLLAAAVAAVLAVLAVLQFAAAAAGPALGEATRGPAVPAAACALGTLLFLARLLAVHGFPRAAAYGLAAACAAQVTALLLVLAARVPGLAVLGRPVELLVAGSAGFRMAAVPAVACGAAALALLAYAGRALTRASAHRKEHNEMTAPPLATPGSNDGGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAZ1</accession>
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            <fullName evidence="6">MFS domain-containing protein</fullName>
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        <lineage>
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        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_29335"/>
    <dbReference type="EnsemblBacteria" id="AKH85665">
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        <property type="gene ID" value="AA958_29335"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AKH85665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="419" mass="43487" checksum="63D079E1749D9487" modified="2015-07-22" version="1">MTTTAPAKRSPLRSGQFRRVIVAEFVSSIGTQMTTLALPWFVLTTTGSPARMGLVFVIQILPVPLLSMPAGLLVARWGARRVSIVGDAVGAVLIAAVPTLYLAGALPFWALLVIVALLGCIASAYLPSQRMLLVETLGTDERVVTAANALFETATSTARLVGPAVAGFLIAGFGPLHVLWVDAATFAVSAVLLLGLPRRKRAPEPMSASKMGEGLSFVLRDPVLKRMSLAAFGYGLLMPVVLLALPVMAKSRYDSDPHVVGWLMAAWGGGTAVGTVVVARLADRIPPVHFAACGGVGAAVMLWLLPWDQPAVTAALTIGAGCMFLPGVTAPAVALLTLRPPEDLRPHVIPLFGAAVFVASPIAYGTAGVLFEHLAVGTVLAAVAVGATLCALILLSLVRHPEADPRREAGDGSAAGITR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NB22</accession>
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            <fullName evidence="2">GATase1_like domain-containing protein</fullName>
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        <lineage>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR010768">
        <property type="entry name" value="GATase1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07090">
        <property type="entry name" value="GATase1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GATase1_like" evidence="2">
        <location>
            <begin position="3"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH85326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="66" mass="6833" checksum="349C39A37AE8D135" modified="2015-07-22" version="1">MLRDEATLLAEIDGDPLIAVREVGAGRTAVFTSGMSAHWAPAGRTADLDVEAPRAAEPATPGTAMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NB68</accession>
    <name>A0A0F7NB68_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATPase AAA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_23905</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018000.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_23905"/>
    <dbReference type="EnsemblBacteria" id="AKH84748">
        <property type="protein sequence ID" value="AKH84748"/>
        <property type="gene ID" value="AA958_23905"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_23905"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5038"/>
    <dbReference type="OrthoDB" id="489714at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="75"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH84748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="349" mass="38393" checksum="83BDAF4FC85E6821" modified="2015-07-22" version="1">MSEWLIYRGTGAPHEGMERLPAPPPWREFDGGPPVPPPAALEPSSERRLGQRRREASHHRPSTRECEMVNAALYLRRPLLVTGQAGSGKSTLAHSVAYELGLGRVLTWPIVSRSTLRDGLYAYDAIGRLQDAQLDRAARRADTAGASGAEGAAEEPGGGIGRYIRLGPLGTALLPSARPRVLLVDELDKSDIDLPNDLLHVLEEGEFTIPELERIADRAPVVEVLSDDGTKVPVRGGRVRCGAFPFIVLTSNGEREFPAPLRRRCIELQLPVPDRARLTGMVRAHFPEGDDERFTELIDRFLAAGPGDVRAVDQLLNAIELTRQADWDQADGSARRVTEELMRPINRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBG2</accession>
    <name>A0A0F7NBG2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Trehalose 6-phosphate phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_19755</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 2">Removes the phosphate from trehalose 6-phosphate to produce free trehalose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>alpha,alpha-trehalose 6-phosphate + H2O = alpha,alpha-trehalose + phosphate</text>
            <dbReference type="Rhea" id="RHEA:23420"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16551"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58429"/>
            <dbReference type="EC" id="3.1.3.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan biosynthesis; trehalose biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the trehalose phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.12" evidence="2"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017334.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_19755"/>
    <dbReference type="EnsemblBacteria" id="AKH84042">
        <property type="protein sequence ID" value="AKH84042"/>
        <property type="gene ID" value="AA958_19755"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_19755"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4163"/>
    <dbReference type="OrthoDB" id="1374424at2"/>
    <dbReference type="UniPathway" id="UPA00299"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004805">
        <property type="term" value="F:trehalose-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044651">
        <property type="entry name" value="OTSB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003337">
        <property type="entry name" value="Trehalose_PPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43768">
        <property type="entry name" value="PTHR43768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02358">
        <property type="entry name" value="Trehalose_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00685">
        <property type="entry name" value="T6PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH84042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="286" mass="29130" checksum="588F906BAA738E74" modified="2015-07-22" version="1">MGSTSAAQLPVPRTEAGRAGLAALLADPEQALLAFDFDGTLAPIVPDPDSARAHPGAVPALARVAPRVGTVAVITGRPAAVAVRYGGFAGVAGLTHLRVLGHYGDEQWDAATGTLRAPDPHPGVAAVQAELPGVLEAAGAWRGTWIEDKGRAVAVHTRRADRPAEAADALRKPLDDLAEAHGLVVEPGRFVLELRPPGMDKGRALTALTRETGARTVLYAGDDLGDLAAYDAVDALRPEGVAGLLVCSAATTGEGADALADRADLTVEGPRGVVDLLTALATALGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBR5</accession>
    <name>A0A0F7NBR5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LuxR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_29075</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018855.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_29075"/>
    <dbReference type="EnsemblBacteria" id="AKH85626">
        <property type="protein sequence ID" value="AKH85626"/>
        <property type="gene ID" value="AA958_29075"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_29075"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6127"/>
    <dbReference type="OrthoDB" id="930905at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="14"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="157"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH85626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="235" mass="25578" checksum="0C6926ADC232E2D4" modified="2015-07-22" version="1">MAEAPASAEQRPIRVFLLDDHEVVRRGLHDLLDAQPDIEVVGDASTAAEAVARGPALRPDVAVLDVRLPDGDGIGVCRELRSRMPELACLMLTSFDEDQALLDAIMAGASGYVLKQIRGDEIVNAVRTVASGKSMLDPSTTARLMESLRHEAEPEPRDAALASLTGRERDILELIGEGLTNREIGKRLYLSEKTVKNHISRMLSKLGVERRIQAAMIATQAKPSAADDKRPDGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBX2</accession>
    <name>A0A0F7NBX2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH-quinone oxidoreductase subunit H</fullName>
            <ecNumber evidence="5">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">NADH dehydrogenase I subunit H</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">NDH-1 subunit H</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nuoH</name>
        <name evidence="8" type="ORF">AA958_20615</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
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            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 6">Cell membrane</location>
            <topology evidence="5 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the complex I subunit 1 family.</text>
    </comment>
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    </dbReference>
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    </dbReference>
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    <dbReference type="PATRIC" id="fig|444103.5.peg.4349"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016655">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01350">
        <property type="entry name" value="NDH1_NuoH"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NADH_UbQ_OxRdtase_su1/FPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018086">
        <property type="entry name" value="NADH_UbQ_OxRdtase_su1_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11432">
        <property type="entry name" value="PTHR11432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00146">
        <property type="entry name" value="NADHdh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00667">
        <property type="entry name" value="COMPLEX1_ND1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00668">
        <property type="entry name" value="COMPLEX1_ND1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0874">Quinone</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0830">Ubiquinone</keyword>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <source>
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        <source>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="AKH84192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="460" mass="50327" checksum="8F45A5E97C52E5C7" modified="2015-07-22" version="1">MIASASAAQGASVLAAEDLSFFGGDPWWLILLKAVFCFAFLMVTVLMAIVFERKVLGWMQLRIGPNRHGPWGLLQSLADGVKLMFKEDIIVKGADKVVYILAPLLAVIPAFMAIAVIPFGPADNQVSIFGERTAMQLTDLPVAMLYVLATASIAAYGVVLAGWASNSTYPLLGGVRATAQVISYEVAMGLSFAAVFLYSGSLSTSEIVAAQDDRWFAVLLPVSFIVYLIAMVGEAHRLPFDMPESEGDLVAGYSTEYSSIKFAMFMLSEYVHMVTLSAVAVTLFLGGWRAPAPVSTVWEGANTAWWPMLWFTGKVLVLLFVFVWLRGTLPRVRYDQFMKLGWKVLIPVSMVWLMLVATVRALRNEDVDFTEIVLYIAGGLLVILLLSFVVDIFRDRKEKEEAAREAAKPTPEFDPMAGGYPVPPLPGQTLPPVPRRPSRRERELVGTNGPGGDTEEADNG</sequence>
</entry>
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        </submittedName>
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        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
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    </dbReference>
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            <end position="46"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="PROSITE" id="PS50977"/>
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        </source>
    </evidence>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NC75</accession>
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        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
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                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
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        </location>
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        </location>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AKH86080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
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        </source>
    </evidence>
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</entry>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018355.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_26070"/>
    <dbReference type="EnsemblBacteria" id="AKH85114">
        <property type="protein sequence ID" value="AKH85114"/>
        <property type="gene ID" value="AA958_26070"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_26070"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5489"/>
    <dbReference type="OrthoDB" id="692375at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="10">
        <location>
            <begin position="124"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="190"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="52"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="383"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AKH85114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="423" mass="44115" checksum="8F9BDBE400B1D73E" modified="2015-07-22" version="1">MSGPRTVLRPRRFTLRARLTLVYGAMFLAAGAVLLGLTYVLFNARLGAGGTFNSSSTEPSAAPTGTPARAPGPGPEPGFEHQRFTESREDVLRDAAGTSLLTQGGIALLVVGAAAAGSGWLVAGRVLAPLHRVTDTARRIADAPAAGRGLHERIALGGPDDEVKELADTFDTMVERLDRSFDGQRRFVANASHELRTPLTLGRALVETAMHRPAASADIRRLGEDLLQINSRHERLISGLLLLASSENEITERHPVDLADIVTHVVAQAVSEAAKAGIEVTVKTAEAWTAGDALLLERLVHNLVENGVRHNSGAGGYVRVTCATGAGGRAELRVANTGPTVPPYEIPALFEPFRRLGADRLVTGGGAGLGLSIVRAVARAHGGDAAARPRDGGGLTVTVTLPPDPDAGRHSGQDAGQRAGPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCE9</accession>
    <name>A0A0F7NCE9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycoside hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_21655</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017634.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_21655"/>
    <dbReference type="EnsemblBacteria" id="AKH84372">
        <property type="protein sequence ID" value="AKH84372"/>
        <property type="gene ID" value="AA958_21655"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_21655"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4560"/>
    <dbReference type="OrthoDB" id="682655at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NlpC/P60" evidence="3">
        <location>
            <begin position="270"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="164"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="223"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="223"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH84372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="385" mass="43245" checksum="615A437489656EB5" modified="2015-07-22" version="1">MASHRKPRTRILESPAGRRTAVGVGFAALASATLLTQEAGATPAERSIEDVQKEVDHLYHEAERATERYNGAKERTAQQRTRVEQQLDEVAKETARLNESRRELGRLAAAQYRTGGITPTATFMLAPDPQTYFDQAHLMERLTNREKAAVDQFQVRQAEAAKKRSEAQESLRTLTDSQEQLQASKQEVQTKLSDARKVLDRLTEAEKKRLAELERKREEEARRKAEEAARQAELERQQQAEQERREQQQREQEQQEEEQQEDPPPADPAPSKSAQVLAFAEAQLGKPYVWGATGPDSYDCSGLTQAAWREAGISLPRTTYDQVNAGTQVAKADLQPGDLVFFYDDVSHVGIYVGNGQMIHASKPGDDVKYESIDYMPFHSGVRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCI5</accession>
    <name>A0A0F7NCI5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_30985</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019134.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_30985"/>
    <dbReference type="EnsemblBacteria" id="AKH85906">
        <property type="protein sequence ID" value="AKH85906"/>
        <property type="gene ID" value="AA958_30985"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_30985"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6548"/>
    <dbReference type="OrthoDB" id="139229at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006775">
        <property type="entry name" value="GH116_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024462">
        <property type="entry name" value="GH116_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04685">
        <property type="entry name" value="DUF608"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12215">
        <property type="entry name" value="Glyco_hydr_116N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydr_116N" evidence="2">
        <location>
            <begin position="21"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="DUF608" evidence="1">
        <location>
            <begin position="453"/>
            <end position="752"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH85906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="834" mass="89578" checksum="EECE56A51755396D" modified="2015-07-22" version="1">MHDTPWPVVRRYRGDRLARIAMPVGGIGTGSIGFGGRGQLLDWELFNRPAKGFTPDSFFCLRAEGAAGSFTRVLESALLPGEYAGHGGSPSALHGLPRFREGEFAAAYPFGQVRLTDPELPVAATVRVFNPLVPGDADASGVPALVYRVTVRNTGAGELAVDVCGNLQHVAGRRPTGGLPAGNAFRLVELDGATVLSGHTTEVAEGDESWGTLALAALEGPVTSHRLTWARRSWGDSLLDFWDDFAADGRLAEPAEGARVPTGSLVVSDRLPAGAEREFTFVLAWHFPNRRGWSHRFQGPPDYGHSADTVGNHYATRYTDAADVVRRIAPRLPDHERRTRAYVEAVTTSSLPPAVQDAVLSNAAVLKTQTCFRIADGTFLAWEGGNPDHGSCHGSCTHVWNYQYALEQLFPDLAWTMREVEFAHALDGRGMMSFRAGLPLDREGTGWRIAAADGQMGALVRLYRTWRLTGRDDLLAALWPGARRALEFAWIPLGWDADRDGLMEGCQHSTSDVEYYGPSGVNQSWYLAALAACERMARALGDHAFAATCAEVLAGGAARTDAELFNGAYYEQKVLPAGSADNIADGLRIRYDGDNPDVGSDDLVDPDLQIGPGCMGDQLAGHTYAVLCGLDDRLDAAHTRTALRSVLRHNHRGEFHSHMNHLRTFALGDEHGLLNCTYPHGGRPTRPFPYCNEVWTGVEYTAALGLAAQGDREAAEHVVADVRDRYDGRVRNPFNEVECGNHYVRSMASFGLAHAWPRTVVDAGAGTVELDPLPGRWPVVAGGHVGTVRVTAGPEGAAAEAVWESVAEGSGGPLTVRLRAAAAGAGEAAAPPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCK8</accession>
    <name>A0A0F7NCK8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_26065</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        <property type="protein sequence ID" value="AKH85113"/>
        <property type="gene ID" value="AA958_26065"/>
    </dbReference>
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    <dbReference type="PATRIC" id="fig|444103.5.peg.5488"/>
    <dbReference type="OrthoDB" id="1020672at2"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
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        <location>
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        </location>
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        <location>
            <begin position="124"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH85113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="218" mass="23393" checksum="1414EBE4F1E7FFF4" modified="2015-07-22" version="1">MRVLVAEDEPVLAAAVRAWLRAEAHAVDVAYDGAAALERAAVHDYDVVVLDRDLPAVHGDDVCRRLVAAGSAARVLMLTASADVADRVAGLGLGADDYLTKPFAFPELAARVHALGRRARPAAPPVLRRAGIALDQARHEVVRDGRYVPLSRKEFAVLAELLRAEGAPVSAELLLEKAWDEHADPFTGAVRLAVLKLRRKLGEPPVVETVTGVGYRIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCT8</accession>
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    </gene>
    <organism evidence="2 3">
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AKH85188">
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        <property type="gene ID" value="AA958_26490"/>
    </dbReference>
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    <dbReference type="PATRIC" id="fig|444103.5.peg.5575"/>
    <dbReference type="OrthoDB" id="2063007at2"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="12"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="122" mass="13346" checksum="94A2B944B7D686C4" modified="2015-07-22" version="1">MILLRRLLGDVLRRQRQRQGRTLREVSSSARVSLGYLSEVERGQKEASSELLNSICEALDVRMSELMREVSGELALAELAQSAAATEPIPAPVRSFTVTSVTGMPDERVTIKAPKEPDPVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCU4</accession>
    <name>A0A0F7NCU4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Phosphoribosyl-ATP pyrophosphatase</fullName>
            <shortName evidence="10">PRA-PH</shortName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 11" type="primary">hisE</name>
        <name evidence="11" type="ORF">AA958_33365</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>1-(5-phospho-beta-D-ribosyl)-ATP + H2O = 1-(5-phospho-beta-D-ribosyl)-5'-AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22828"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:59457"/>
            <dbReference type="ChEBI" id="CHEBI:73183"/>
            <dbReference type="EC" id="3.6.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the PRA-PH family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.31" evidence="3 10"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019530.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_33365"/>
    <dbReference type="EnsemblBacteria" id="AKH86305">
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        <property type="gene ID" value="AA958_33365"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_33365"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.7046"/>
    <dbReference type="OrthoDB" id="2022633at2"/>
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        <property type="reaction ID" value="UER00007"/>
    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HisE"/>
    </dbReference>
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        <property type="entry name" value="PRib-ATP_PPHydrolase-like"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AKH86305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="90" mass="9916" checksum="2D1CF8F094B96E02" modified="2015-07-22" version="1">MASKTFEELFAELCQKAATGDPATSRTAQLVEQGVHAIGKKVVEEAAEVWMAAEHEGEERTAEEISQLLYHLQVMMVARGISLDDVYAHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCX4</accession>
    <name>A0A0F7NCX4_9ACTN</name>
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        <recommendedName>
            <fullName evidence="1">Sigma70_r4_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_22870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017829.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_22870"/>
    <dbReference type="EnsemblBacteria" id="AKH84572">
        <property type="protein sequence ID" value="AKH84572"/>
        <property type="gene ID" value="AA958_22870"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_22870"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4816"/>
    <dbReference type="OrthoDB" id="1914729at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r4_2" evidence="1">
        <location>
            <begin position="118"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="183" mass="21149" checksum="2D4F9EC5BB3C2483" modified="2015-07-22" version="1">MTEEVPAEDHSSPVTHAMLHVPPVCEALYLANADAYFTYAQYWLDDETAEEAIHLAFHQIRNRWEELGRHGDLRQQAWAILRRVVASYVEESAVRREIAHVLAVYQELLEQQHAGVGLYEAIAKLSPRQFDVVVLRYLCKFPTERIAWYLGVTASTVDYHCRRATKRLERDLAQLLKKDGDTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-10-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7ND56</accession>
    <name>A0A0F7ND56_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_27270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH85318">
        <property type="protein sequence ID" value="AKH85318"/>
        <property type="gene ID" value="AA958_27270"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_27270"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5746"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH85318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="78" mass="8264" checksum="ABE3B1380D24DD10" modified="2015-07-22" version="1">MPAGYIVTVFIFKYLALPPRPEDRPAGPAGAGGERLLCARVPADMPVESGDTVDLAMRPEALHYFAPADGARLPDGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7ND71</accession>
    <name>A0A0F7ND71_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Molecular chaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_23575</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017947.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH84692">
        <property type="protein sequence ID" value="AKH84692"/>
        <property type="gene ID" value="AA958_23575"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_23575"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4969"/>
    <dbReference type="OrthoDB" id="1990300at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000390">
        <property type="entry name" value="Small_drug/metabolite_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045324">
        <property type="entry name" value="Small_multidrug_res"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30561">
        <property type="entry name" value="PTHR30561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00893">
        <property type="entry name" value="Multi_Drug_Res"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH84692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="107" mass="11071" checksum="0DC569E5C9009A98" modified="2015-07-22" version="1">MAWLLVVVAGILETGFAVCLKLSHGFTRLWPTVAFCVFALGSFGLLTLSLKKLDVGPAYAVWTGIGAAGTAIYGMAFLGDMVSTLKLVSISLVIVGVIGLQLSGSAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDE2</accession>
    <name>A0A0F7NDE2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_23875</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017994.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_23875"/>
    <dbReference type="EnsemblBacteria" id="AKH84742">
        <property type="protein sequence ID" value="AKH84742"/>
        <property type="gene ID" value="AA958_23875"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_23875"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5031"/>
    <dbReference type="OrthoDB" id="913951at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519971" evidence="4">
        <location>
            <begin position="32"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="5">
        <location>
            <begin position="41"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="5">
        <location>
            <begin position="138"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="111"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="206"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH84742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="330" mass="34462" checksum="8C05918164CE8A5F" modified="2015-07-22" version="1">MRPTPTLAALSTTAACLLALTAASCGSDGEAAAEPPETPTVPTGVTVYTSTSTSVHVMWNKAAEAENVRRYEVYRNGKKIQNVPAEKHMTDITGLKPSSSYTFAVRARDADGKLSGPGQAPAVTTPSADADDSKPPTRPASLKARADGPRSATLTWTRAEDDKEVTSYDIYQEGTKIHSVGGTESTAAVTTLRPDTDYTFTVKARDAAGNSGPASPSASVTTEPEPGGKAGAEIPTDLQATARKDAGTWNLDLVWNAPKAGGDITEYEVYVDGTFASKLVLGESAPKDTGRISLPLEKSGKATYAVKVRAKLPDGKWGPFTKDVTVQAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDE4</accession>
    <name>A0A0F7NDE4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4037 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_33145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019491.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86266">
        <property type="protein sequence ID" value="AKH86266"/>
        <property type="gene ID" value="AA958_33145"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_33145"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.7002"/>
    <dbReference type="OrthoDB" id="681174at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025117">
        <property type="entry name" value="DUF4037"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13228">
        <property type="entry name" value="DUF4037"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4037" evidence="1">
        <location>
            <begin position="134"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="357" mass="39100" checksum="0948660150CC778F" modified="2015-07-22" version="1">MNAAFRPGLALAGDFHTEAVAPLLDRVLPGTPYAAALLGWGSEVQGFDTPRSTDHAWGPRLQVFLAPAAHRAHAAELTALLDRELPERFGGYPVRFAFPGGTAPRHWVDVLDTGAHFAEQLGEVPDGGLSVGGWLAAPWQVLRELTGGAVFHDGAGVLTAYREHLRWYPDPVWRYVLACQWQRLHQEEPFVGRCGEVGDDLGSAVTAARQARELMRLCLLMHRVYPPYGKWLGSAFAALPEAAELAPLLSGALAARGWRERERQLSPAYERVARLHNELGLTEPLAPEVRPFHERPFLVLGAERFCAALLATVRDPELVALPPVGSVDQYADSTDLTAHGFADRRRRYLARPGGPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NEA3</accession>
    <name>A0A0F7NEA3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Imidazole glycerol phosphate synthase subunit HisH</fullName>
            <ecNumber evidence="8">4.3.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">IGP synthase glutaminase subunit</fullName>
            <ecNumber evidence="8">3.5.1.2</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">IGP synthase subunit HisH</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">ImGP synthase subunit HisH</fullName>
            <shortName evidence="8">IGPS subunit HisH</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">hisH</name>
        <name evidence="11" type="ORF">AA958_06375</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + H(+) + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24793"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="ChEBI" id="CHEBI:58525"/>
            <dbReference type="EC" id="4.3.2.10"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 8">
            <text>H2O + L-glutamine = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 5/9.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterodimer of HisH and HisF.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="4.3.2.10" evidence="8"/>
    <dbReference type="EC" id="3.5.1.2" evidence="8"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019823.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_06375"/>
    <dbReference type="EnsemblBacteria" id="AKH86576">
        <property type="protein sequence ID" value="AKH86576"/>
        <property type="gene ID" value="AA958_06375"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_06375"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1331"/>
    <dbReference type="OrthoDB" id="1726024at2"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000107">
        <property type="term" value="F:imidazoleglycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01748">
        <property type="entry name" value="GATase1_IGP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00278">
        <property type="entry name" value="HisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010139">
        <property type="entry name" value="Imidazole-glycPsynth_HisH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42701">
        <property type="entry name" value="PTHR42701"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000495">
        <property type="entry name" value="Amidotransf_hisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01855">
        <property type="entry name" value="IMP_synth_hisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="6 8" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GATase" evidence="10">
        <location>
            <begin position="18"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8 9">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <feature type="active site" evidence="8 9">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <feature type="active site" evidence="8 9">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000495-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AKH86576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="222" mass="23744" checksum="63404E15748D954B" modified="2015-07-22" version="1">MPAARRGEGGGGRKSVVVFDYGFGNVRSAERAVARAGAEVEITGDYDRAMAADGLLVPGVGAFAACMGGLKEARGDWVVERRLAGGRPVLGICVGMQILFEQGVEHGVRTDGMGEWPGTVEALRADVVPHMGWNTVEVGAGSRMFAGIDAGERFYFVHSYAARRWELEVHNPRISPPAVTWSTHGEPFVAAVENGPLWAAQFHPEKSGDAGALLLKNWIETL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NED4</accession>
    <name>A0A0F7NED4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_25685</name>
        <name evidence="5" type="ORF">AA958_25705</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_25685"/>
    <dbReference type="EnsemblBacteria" id="AKH85050">
        <property type="protein sequence ID" value="AKH85050"/>
        <property type="gene ID" value="AA958_25685"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH85052">
        <property type="protein sequence ID" value="AKH85052"/>
        <property type="gene ID" value="AA958_25705"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_25685"/>
    <dbReference type="KEGG" id="strc:AA958_25705"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5414"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH85050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH85052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="174" mass="18933" checksum="28D007423AA89614" modified="2015-07-22" version="1">MVAGGFGVGKTTFVGSVSEINPLRTEAVMTSASAGIDDLSQVSGKTTTTVAMDFGRITLDQDLILYLFGTPGQDRFWFMWDDLVRGAIGAVVLVDTRRLADCFPAVDYFENSGLPFVIALNGFDGHQPYSPDEVREALQIGPETPILTTDARQRSESKSTLITLVEHALMARLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NEX8</accession>
    <name>A0A0F7NEX8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_31600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_31600"/>
    <dbReference type="EnsemblBacteria" id="AKH86009">
        <property type="protein sequence ID" value="AKH86009"/>
        <property type="gene ID" value="AA958_31600"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_31600"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6674"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="130" mass="14960" checksum="93FBC77302D68F40" modified="2015-07-22" version="1">MLRTAARMIDVMPTSQPSDETSYDRRRLRQWLDGRRPHPGRRPARHAAALRRRRRGRRAGRPRRRAKLAGAPRADGWVRWSADWRPEKPGPADVRARATDVSGRTQPERTVPNDQGYLFDAVVRHPVTVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NF16</accession>
    <name>A0A0F7NF16_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_31910</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Antibiotic biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019287.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_31910"/>
    <dbReference type="EnsemblBacteria" id="AKH86059">
        <property type="protein sequence ID" value="AKH86059"/>
        <property type="gene ID" value="AA958_31910"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_31910"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6739"/>
    <dbReference type="OrthoDB" id="572620at2"/>
    <dbReference type="UniPathway" id="UPA00189">
        <property type="reaction ID" value="UER00296"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901362">
        <property type="term" value="P:organic cyclic compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010060">
        <property type="entry name" value="NRPS_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01720">
        <property type="entry name" value="NRPS-para261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="3 6" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="966"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="6">
        <location>
            <position position="1001"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH86059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="1544" mass="163459" checksum="8BCC9E06F10A238E" modified="2015-07-22" version="1">MNPSAVAKGSALAEMWPLSPLQEGLLFHAGFDTDSPGVYAVQFMLDVDGPLDHRRFRAAWAGLLARHPALRASFHRRPSGEAVQLITREVALPWRDADLSALPRADALAETQALADAERARPIDLAAAPLLRLLLVRLGEERHRLVVTTHHILIDGWSMPILLRELAAVYEAGGDLSMLKPAPSYGQYLAWLRRQDKGRAQAAWRAELAGADEPTLVVPRDALEGPVVPGRVRFTLGAELSAGVAELARAHGLTVNTVVQGAWALVLARLTGRDDVVFGATAAGRPPELPGVEAMVGLFINTLPVRVRLDPARPAVELLADLQRRQVGLMAHQHIGLPDVQKLAGPGATFDTLVVYENYPLTSAESDDPEALSIRFAGEPQDAGHYPLTLIAWPGEQLRAELFYRRDVFEPGRAETVTASFVRVLEQLVADPAAPVGRLDAIDARRRALVTTRCNDTAAPVPEPLAPELFSVQVGRSSGAVALVAGGESLSYGKLGGRVGRLGRYLVAAGVGPEVRVAVVVERSALLVEALLAVSLAGGVFVPVDPGYPPERVVFVLGDADPAVVLCTVATRDVLPEDVGAVVLDDPAVAAEVVAYPGGVLRAEERRGPLTADHAAYVIYTSGSTGTPKGVVVSHHGLRNLVADRLAQYGFGPGSRVLQLVSPSFDVSMSDIWPVLCAGGRLVLGPVRLDLSGHELTRLMRDERVTYVATTPTLLAEVPPADLPELRSVVLGGEPGSPELRRRWLAGRELFNEYGVTEATVASTLGRIHDSRGTPPIGGPVTNSRVYALDAFLQPVPPGVAGELYLAGAGVARGYLGRQGLTAERFVACPFMPGERMYRTGDLVRWTDDGELVFVGRADEQVKVRGHRIELGEIEAALREAAGVAEAVVVARADGPGDKRLVGYVVPEGPDVDPRRVREEAAAALPDYMVPAAVLVLPGLPRTTSGKIDRTALPAPDFAEHATGRPPEGETETALCALFAEVLGLERVGADDDFFALGGDSITSMQLASRARRAGLVLTPRQVFDERTPERLAVPAALAAAPAAADGADSGVGEVPWTPVMCRLGPQTAGREFAQWTVVGAPAGLGPEALAGGIGALLDTHDVLRARADLSHEADPRLLVAQRGTVDPAARVTRIDAANIDDLDGLAEQAARAAVNRLDPANGVMVHAVWLDAGPARVGRIALLVHHLVVDGVSWRILLPDLRAACEAVGEGRKPALEPVATSFRRWSRELAAQAVSKDRQAELEHWSAQLGAGAPALTRRPPDPATDTVVSLQNESWTLPADQAVTLTGRTPAAFHCGVHEVLLATLAAAVAYWRPGARATVLVDVEGHGREPAGNLDLSRTVGWFTSVHPLRLDLQGIDLDDVRAGGPAAGRLLKAVKEQAQAVPGDGLGYGLLRYLNADTAAAVAALPQPQLGFNYLGRFPARGAGPVAAWQPAGERAVGGTAPPDMPILHTLGTNAVVRDSAAGPELSFTLGWPPDLLDRADAERLGDTWLEMLAGLAAHTEDPAAGGHTPSDFPLLDLGQDDVERLEEIAGTIEGGLFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFA2</accession>
    <name>A0A0F7NFA2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_27590</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018606.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH85372">
        <property type="protein sequence ID" value="AKH85372"/>
        <property type="gene ID" value="AA958_27590"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_27590"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5814"/>
    <dbReference type="OrthoDB" id="2017992at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH85372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="271" mass="28945" checksum="D7E79DDC957478C2" modified="2015-07-22" version="1">MAGVNGGGERVRTYRGNLASMVLLALLCALFGALFVFFGLLLVIGADAPAAVAIPFCAVALGLFLLTFCVVRGVTVVDDGGITIRWLRTRRLAWPDLLAVELEHNVPASAERKRPVMGVVVYHRDGRRLTLPNVIDTRGLVAHREVQAIREVWERRRGEDWTPRPEVTAAARAKADAAERNENALVEAMGFSLTAVRVLVGCILVVAVVFLATGNADAFPDIPGGVIAVVFAAVAVAPVAIALAGRARRRRGEGEGEGEGPDREGDEAPPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFQ2</accession>
    <name>A0A0F7NFQ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Radical SAM protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_28665</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018791.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_28665"/>
    <dbReference type="EnsemblBacteria" id="AKH85557">
        <property type="protein sequence ID" value="AKH85557"/>
        <property type="gene ID" value="AA958_28665"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_28665"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6040"/>
    <dbReference type="OrthoDB" id="979208at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040086">
        <property type="entry name" value="MJ0683-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43432">
        <property type="entry name" value="PTHR43432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01084">
        <property type="entry name" value="Uncharacterised_Radical_SAM_Su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="7">
        <location>
            <begin position="59"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="325"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH85557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="352" mass="38936" checksum="928374AEB7EF2947" modified="2015-07-22" version="1">MRWENLTDEAADGGAATGAGPPALFGTAAVVTRTFDTPEFRGITFHEVRARSIVNRVPGASRMAFDWTVNPYRGCSHACVYCFARKTHGYLDLDTGRGFDSQIVVKINAPELLRRELASRRWRGEHIAMGTNVDCYQRAEGRYRLMPGILAALRDFANPYSILTKGTLILRDLPLLKQSAEVTQVGVAVSVGFLDEELWRTVEPGTPAPQRRLDVVRTLAEHGIGCGVLMAPVIPFLSDSPRQLRATVRTVAEAGATSVTPLVLHLRPGAREWFMAWLEYHHPHLVRRYRTMYAGGSYAPKWYQRQITRQVHEYAAELGIGPSAPGIARRIEPEGGPGAPPEGPENTQLTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFQ3</accession>
    <name>A0A0F7NFQ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_29915</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020543.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH87131">
        <property type="protein sequence ID" value="AKH87131"/>
        <property type="gene ID" value="AA958_29915"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_29915"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6317"/>
    <dbReference type="OrthoDB" id="1796334at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="9"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH87131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="336" mass="35535" checksum="9944277EA4FABD8D" modified="2015-07-22" version="1">MTDVPRRQPTLDEVAERAGVSRSAASRVLNNAPHVSPAKRAAVLRAIRELDYVPNTTARALATRQRGAVALVISGEAPSIFADPFFAKVIVGASGALEGADLHLMLCLAASERSRGRLAGLLRARGVDGAMFMAVRENDPVLHLAREAEVPVVFGGRPAGFDPPRYVDVDNAGGAREATEHLLARGRRRVGMICGLPDTEASRARHRGYREAMILAGLRPLPPEYGDFTEPSGAAAMATLLKRQPELDGVFAANDNMAAGALRTLRGSGRAVPADVAVVGFDDLDIARIAEPSLTTVHQPIEALGNEMARMLAGLIAGEDPSSLILPTHLVARSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFS1</accession>
    <name>A0A0F7NFS1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Putative pterin-4-alpha-carbinolamine dehydratase</fullName>
            <ecNumber evidence="3">4.2.1.96</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_28780</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin = (6R)-L-erythro-6,7-dihydrobiopterin + H2O</text>
            <dbReference type="Rhea" id="RHEA:11920"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15642"/>
            <dbReference type="ChEBI" id="CHEBI:43120"/>
            <dbReference type="EC" id="4.2.1.96"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pterin-4-alpha-carbinolamine dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.96" evidence="3"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018810.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_28780"/>
    <dbReference type="EnsemblBacteria" id="AKH85577">
        <property type="protein sequence ID" value="AKH85577"/>
        <property type="gene ID" value="AA958_28780"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_28780"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6065"/>
    <dbReference type="OrthoDB" id="1862336at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008124">
        <property type="term" value="F:4-alpha-hydroxytetrahydrobiopterin dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006729">
        <property type="term" value="P:tetrahydrobiopterin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036428">
        <property type="entry name" value="PCD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001533">
        <property type="entry name" value="Pterin_deHydtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12599">
        <property type="entry name" value="PTHR12599"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01329">
        <property type="entry name" value="Pterin_4a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55248">
        <property type="entry name" value="SSF55248"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH85577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="102" mass="11149" checksum="A16B06667F3F908D" modified="2015-07-22" version="1">MAVEPLSPQDTEDRLARLPGWSVAEGELLSRTYRFDSHPPAAAMVADVSRIQEELGHHAMLTLGYNTLDIAVNTHSVGGRVTELDFDLARRIEDVAPEHGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFS5</accession>
    <name>A0A0F7NFS5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">XRE family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_28805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018815.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_28805"/>
    <dbReference type="EnsemblBacteria" id="AKH85582">
        <property type="protein sequence ID" value="AKH85582"/>
        <property type="gene ID" value="AA958_28805"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_28805"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6070"/>
    <dbReference type="OrthoDB" id="922937at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041413">
        <property type="entry name" value="MLTR_LBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17765">
        <property type="entry name" value="MLTR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="9"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="279" mass="31078" checksum="2A266E30ED70D2B9" modified="2015-07-22" version="1">MDRTELADFLRRSRARLTPADVGLPPGARRRTPGLRREEVAQLAGMSADHYTRLEQARGSRPSRQMLAAVARGLRLGDDERDHLFHLAGEEPPRARGAGAHVRPGLLLILDRLTDTPAQVLADCGDVLAQNALSRALSGDTADRAGDGRNIVWRFFTEPESRALIPPEDREDVARRAVADLRATVARRPDDTRVAGLVRRLRARSAEFAALWEAHDVAVRRREAKRFVHPVVGLLELDCEVLLNPEHDQRLVVYTARPGSESHQRLELLRVVGLQRLTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFU0</accession>
    <name>A0A0F7NFU0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Xylose isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_28890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018830.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_28890"/>
    <dbReference type="EnsemblBacteria" id="AKH85597">
        <property type="protein sequence ID" value="AKH85597"/>
        <property type="gene ID" value="AA958_28890"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_28890"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6087"/>
    <dbReference type="OrthoDB" id="1007505at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="22"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="290" mass="31323" checksum="5D1D8A6133E99D0E" modified="2015-07-22" version="1">MSRLRLAYGTNGLTDLRLTDAVALLADLGYDGIALTLDHMHLDPLAPDLPARTATVRRLLARHGLAVTIETGARYVLDPRRKHHPTLLDPDPEARAVRSRLLRTAVNVAAELGANAVHCFSGTRPYGVSEPDAWKRLGEELIPVLQAADAAGVPLAIEPEPGHLLYDLAGFHRLRGELDDPPALALTLDIGHCQCLEEALPADCVRAAAPWLAHVQIEDMCRGVHEHLPFGEGEIGFPSVLEALQTTGYQGLISVELPRHSHAGPELASSSIRFLRAAEEEARARGPVPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NG87</accession>
    <name>A0A0F7NG87_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_29980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018980.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH85752">
        <property type="protein sequence ID" value="AKH85752"/>
        <property type="gene ID" value="AA958_29980"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_29980"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6331"/>
    <dbReference type="OrthoDB" id="1953692at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH85752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="168" mass="17189" checksum="8112455683C87620" modified="2015-07-22" version="1">MDFTTSALILSWAAIALLALVVSGLVRQVHQLSRGAVVRSPGRLGVTPGSSAPHADELLAADRETLLLFLSAECRTCAEVLAAAGRLDGPTAVRAVYAGDAPPATEAGVPVTENRPDLFTAYDAIATPFAVLVGTTGRVVRSEPLGSADALGDLVAAAPHHTSQPRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NGH2</accession>
    <name>A0A0F7NGH2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_33830</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019610.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86388">
        <property type="protein sequence ID" value="AKH86388"/>
        <property type="gene ID" value="AA958_33830"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_33830"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.7144"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519435" evidence="2">
        <location>
            <begin position="31"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH86388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="88" mass="8719" checksum="810CD7345F2A42AD" modified="2015-07-22" version="1">MRRTGALAAALSSAALLGFTALAAAPAASAAPAGDTAYAATATAEEGGDGDEMPYGVDLRMHDDGSVSVVALTEDDIDDESGHWHSVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NGV9</accession>
    <name>A0A0F7NGV9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_03935</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019761.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_03935"/>
    <dbReference type="EnsemblBacteria" id="AKH86533">
        <property type="protein sequence ID" value="AKH86533"/>
        <property type="gene ID" value="AA958_03935"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_03935"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.826"/>
    <dbReference type="OrthoDB" id="66530at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012961">
        <property type="entry name" value="Ski2_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08148">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01142">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="45"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="3">
        <location>
            <begin position="289"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="655"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="671"/>
            <end position="692"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH86533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="945" mass="104800" checksum="465D9FC4AAEE100B" modified="2015-07-22" version="1">MTDEHIPPAEAYAAHRRRAAEEATALGSFRGLYDFALDPFQLDACRALEDGRGVLVAAPTGSGKTVVGEFAVHLALEQGRKCFYTTPIKALSNQKYGDLVRRYGAANVGLLTGDNTINSDAPVIVMTTEVLRNMLYAGSQTLLGLGYVVMDEVHYLSDRFRGAVWEEVIIHLPESVTLVSLSATVSNAEEFGSWLDTVRGDTAVIVSEHRPVPLWQHVMAGRRMYDLFEERTAAGGRQEPAKAVNPDLLRLARQEYARPSGPRDRRRGRGREADRERERRSRSRVWTPSRVEVIERLDAEALLPAITFIFSRAGCEGAVQQCLYAGLRLNDEEERAAVREIAELRTAAIPREDLHVLGYFDWLEALERGIAAHHAGMLPTFKEVVEELFAKGLVKAVFATETLALGINMPARSVVLEKLVKWNGETHADVTPGEFTQLTGRAGRRGIDIEGHAVVLWQRGMSPEYVAGLAGTRTYPLRSSFRPSYNMAVNLVAQFGRHRTRELLEMSFAQFQADKSVVGISRQVQKNEEGLSGYREAMTCHLGDFEEYARLRRDLKDRETELARQGAAQRRAAAAGSLEKLRPGDVIHVPTGKFAGLALVLDPGTPAGRTNGHRGFEQHDGPRPLVLTAARQVKRLAAMDFPVPVEALERMRIPKSFNPKSPQSRRDLASALRTKAGHLEPRRHRKERAPAADDAEIARLRKAIRAHPCHGCDEREDHARWAERYHRLLRDTHQLERRIEGRTNTIARTFDRVYALLTEVGYIAEQDGGEKVTEDGRRLARLYGELDLLASECLREGVWEGLGPAELAACASALVYEARQSDDAMAPKLPGGGAKRALGDMVRIWGRLDALEEDHGIRQTEGVGQREPDLGFAWAAYQWASGRSLDEVLREADMPPGDFVRWCKQLIDVLGQLSAATDPESTVAGSARKAVDKVLRGVVAYSSVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NH01</accession>
    <name>A0A0F7NH01_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_12490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019989.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_12490"/>
    <dbReference type="EnsemblBacteria" id="AKH86714">
        <property type="protein sequence ID" value="AKH86714"/>
        <property type="gene ID" value="AA958_12490"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_12490"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2624"/>
    <dbReference type="OrthoDB" id="1253502at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030802">
        <property type="entry name" value="Permease_MalE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30188">
        <property type="entry name" value="PTHR30188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02405">
        <property type="entry name" value="MlaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="248"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="274" mass="29012" checksum="55F1167034D43F8A" modified="2015-07-22" version="1">MRAGRLLDRPLSWLDQAGDQLVFYVRALLWTPRAARRYLKEVQRLLAEVAFGSGGLGVIGGTIGVMFAMTLFTGTVVGLQGYAALNQIGTAAFTGFVSAYFNTREIAPLVAGLALSATVGAGFTAQLGAMRINEEVDALEGMGVRSMPYLVTTRIIAGVVAIIPLYGIGLLSSYLASRAVTVLYNGQAAGTYDHYFNLFLSPADVLLSFMKVLIFSVMVILAHCYYGFRATGGPAGVGVAVGRSVRTAIVLIAVTDFFLSLAIWGTTTTVKVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NH35</accession>
    <name>A0A0F7NH35_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_31830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86047">
        <property type="protein sequence ID" value="AKH86047"/>
        <property type="gene ID" value="AA958_31830"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_31830"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6722"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH86047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="89" mass="9436" checksum="6F33AD9E883E182A" modified="2015-07-22" version="1">MPRAGCSGTRGTCGSAPGAAPLAPAATCRFWPRHHRALHRGPQNLLLGLLLVQVNAARHSAQYRVWVAMDPPRPARQRAGTVGSGFGDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-12-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NH96</accession>
    <name>A0A0F7NH96_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">von Willebrand factor type A domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_10185</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019926.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86658">
        <property type="protein sequence ID" value="AKH86658"/>
        <property type="gene ID" value="AA958_10185"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_10185"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2144"/>
    <dbReference type="OrthoDB" id="692608at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021908">
        <property type="entry name" value="DUF3520"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022156">
        <property type="entry name" value="Uncharacterised_YfbK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12034">
        <property type="entry name" value="DUF3520"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12450">
        <property type="entry name" value="vWF_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="160"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="462"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH86658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="533" mass="55489" checksum="6C750B2501A24983" modified="2015-07-22" version="1">MTVPLLLTGCSGGGGDTSDKQVSHDRAGGGSAPLPAPAAPSAAPEGAYDAAPEAAGKERADSFVPEPDMVSTFALDVDTASYSYARRTIDSGALPQPDTVRHEEFINSFSQDYPAPEDDGFSVTTDGARTADDRWSLMRVGLATRPESNEYGTQPRRPAALTFVVDVSGSMAEPGRLSLVREALHTAVDELRDDDALALVAFSDEARTVLPMTAVGGAEDRIHDAVEELQPTESTNLGAGVARGYDEAVDGHRKGATNRVVLLSDALANTGATDAETILDRIAAAREDYGITLFGVGVGSEYGDALMERLTNQGDGHTAYVSGTTEARKVFVEDLPRNVDLRARDAKAQVVFDADAVSDYRLIGYDNRRVADEDFRNDAVDGGEVGPGHTVTALYAVRLAEGASGSVATATVRWLDPDTRAPHEESSTVDAGALTGDLWGAAPPRLQLTALAAYFADALRGGSGAGTTPTPTPEPYADGKEGAGTTGAGYLPLPGAPTVDELAGHAEDLAAETEDPAVGDLAETVRQAVELTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NHK8</accession>
    <name>A0A0F7NHK8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_19655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020259.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_19655"/>
    <dbReference type="EnsemblBacteria" id="AKH86914">
        <property type="protein sequence ID" value="AKH86914"/>
        <property type="gene ID" value="AA958_19655"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_19655"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4141"/>
    <dbReference type="OrthoDB" id="1687413at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="9"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="181" mass="19181" checksum="E26A9D0C2BA384DA" modified="2015-07-22" version="1">MGNTGNTSWITRAETRADIPVIREITLAAFGRAHEADIVDTLRADESAWIEGLSLVVTEPAAADDTTGAALLGHILLTRGHIGDTPALCLGPVSVRPERQRDGVGSVAMRAALAAAAARGERYVVLVGHPEYYPRFGFTRASAYGIRLSVEVPDDALMALALDEAHPLPGGMIRWPAAFGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NI35</accession>
    <name>A0A0F7NI35_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_20515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_20515"/>
    <dbReference type="EnsemblBacteria" id="AKH86928">
        <property type="protein sequence ID" value="AKH86928"/>
        <property type="gene ID" value="AA958_20515"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_20515"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4325"/>
    <dbReference type="OrthoDB" id="1736628at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="122" mass="12941" checksum="C0B933CE9B13C919" modified="2015-07-22" version="1">MHIVLDDTAMTSAGQGNVLTSRLIHRAHAEPGWFLYAPACALVEADRHRPGTAEHLAALPGITVLDLDLPAALAVAKQKTWAAAHSSHAAQPTPDRPDGAVLATTAPERWEGQQVRVLDLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NIC9</accession>
    <name>A0A0F7NIC9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NADH dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_32700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NADH dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020636.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_32700"/>
    <dbReference type="EnsemblBacteria" id="AKH87199">
        <property type="protein sequence ID" value="AKH87199"/>
        <property type="gene ID" value="AA958_32700"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_32700"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6909"/>
    <dbReference type="OrthoDB" id="403436at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006116">
        <property type="term" value="P:NADH oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045024">
        <property type="entry name" value="NDH-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706">
        <property type="entry name" value="PTHR43706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="2">
        <location>
            <begin position="1"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH87199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="432" mass="46760" checksum="497F998BEC66E76C" modified="2015-07-22" version="1">MVVGAGFAGYQAARTLARRAPDGAEIVLINPNDYFLYVPMLPYVATGVLEARHICVPLARLRPRVRLVLGEVDTVDLAAGRVLWTGPEGHRGETPFDRLVVTVGSVSKLLPVPGVAEHAHGFRGIPEALYLRDHVTRQIELAASTKDEEERAARRTFVVVGAGYTGTEVAAHGALFTRALDRRYDARRDGPRPRWMLLDIAPRIMPEMDERMSRSATDVLRRRGVDVRTGRSVKEATSDGVLLDDGEFVGTRSLIWCVGVRPDPLVESVGLPLEKGRLVVDEFLNVPGHPEVYACGDAAAVPDPDRPGEYTTMTAQHAMPQGRLAGRNVAASLTGGRQQPYRHRPRGFAVDLGGVNAAADPFGVQIAGPLAAALTRGYHLLAMPSGRARVAVDWTMDALLPRQAVQLGLVGSWSVPLDTASPETPRIPDGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NIT8</accession>
    <name>A0A0F7NIT8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_31715</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="2"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020612.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_31715"/>
    <dbReference type="EnsemblBacteria" id="AKH87178">
        <property type="protein sequence ID" value="AKH87178"/>
        <property type="gene ID" value="AA958_31715"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_31715"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6697"/>
    <dbReference type="OrthoDB" id="114076at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="6">
        <location>
            <begin position="180"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="201"/>
            <end position="208"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH87178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="749" mass="80187" checksum="C4823A9CE002152B" modified="2015-07-22" version="1">MRREQEFLDLLRQRLTELRDGAAAGVRAALARDGGNTLQARLERDVLVAEQSGLLAAFNAGEQGLCFGRLSFRDGRDHHIGRIGMRADDEERTPLVVDWRAEVARPFYLATGHTPMGLRRRRHISTEGGPDGPRITGLHDEILDLTDTERTGLEGADADAVLLAALDAARTGRMHDIVQTIQADQDRIIRAPHRGVLVVEGGPGTGKTAVALHRAAYLLYAHREQLARRAVLIVGPGPAFLGYISEVLPALGETGVLLATPGELFPGVDATGTDTPAAAAVKGGTAMAGALAAYLRDRQRLPESTVVIPHEDGELHLDYWLANAARRRARDTELPHNAAQPHFAFNVIDGLTRQLTDRLGEDPFGDENLLGPDDIAQLGKAVAANEEVHAAIAELWPLLTPQELVADFLAGPVHLPEADGELIRRAGGPWTPADVPLLDEAAELLGDDGPAQAAARARAEAERQERIAYAQGVLEMSYGSRTQEFEDRDDDEAEVLAAHDLIDAERLAERQEEADHRTAAERAAADRTWAFGHIIVDEAQELSPMAWRLLMRRCPTRSMTLVGDPAQTAEPGACGAWEAILGPYVDKRFEHITLGVNYRTPAEIMEVAAEVARAEDPGYVPPRSVRATGVRPWAERAGEGPGAVPAAVAAAVARESDGAGRLAVIAPRELLPALTAALPDAASGAAPDLTRPVVLLGPRQAKGLEFDTVIVAEPALFGSSDLYVALTRATQRLGVVYADALPAALGGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MX98</accession>
    <name>A0A0F7MX98_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_00215</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH80850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014217.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_00215"/>
    <dbReference type="EnsemblBacteria" id="AKH80850">
        <property type="protein sequence ID" value="AKH80850"/>
        <property type="gene ID" value="AA958_00215"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_00215"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.49"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.101.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036366">
        <property type="entry name" value="PGBDSf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="SSF47090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="383"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="38"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="60"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="407"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="407"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="473"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="499"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH80850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="594" mass="62723" checksum="B80452A3CBC58057" modified="2015-07-22" version="1">MAETDPAHPWTDELSAADLEQLGVEPLRRTDPVTVGPYRVLARLGGGGMGRLYLGREATVPSTAASRPSPPATAGGPAPETGDDESVAYGAGSLVAVKTIRPEYVEDAPFRRRFEREVAAVRRVHGRYTASLLGSGFDNDEHLWMATAYVPGLSLEDTVRRFGSLSAPVVWRLASEVGQALTSIAAVGIVHRDLKPSNVLLGQDGARVIDFGVSHTADASALTVTGQHLGTPAFMSPEQADGGRVGTASDVFSLGSVLALAATRRAPFGGESAGEVIHRVIYSEPSAEVLEEVASADPALADLISRCLDKDATRRPTPQQIVNAVHAQASAAQWPATVNDLIEARTAWVGRTASVPQADQLTVLRRAAPAHTPRPRKHGRRRALVLSAVVAGIAAVTTVVAMAATNSHPSGTAAPSQPSSPHTSPHRTAPSPSHRSGQPSDVPESTTPTPTHTATPEPPEIVVTIPPAAPKETEEPDVTEPPAESRTPDRRPAEKPRPTTTVTSPPRPPASKPAKPWESCTFYSGTALTDYGDRGRRVSQVQCILTKRGYSVGPDGVDGDFGPNTQAAVKKFQSRHHLQVDGQVGVFTWAALRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MXB3</accession>
    <name>A0A0F7MXB3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Urease accessory protein UreG</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ureG</name>
        <name evidence="6" type="ORF">AA958_00330</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer. UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the SIMIBI class G3E GTPase family. UreG subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH80870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014236.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_00330"/>
    <dbReference type="EnsemblBacteria" id="AKH80870">
        <property type="protein sequence ID" value="AKH80870"/>
        <property type="gene ID" value="AA958_00330"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_00330"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.78"/>
    <dbReference type="OrthoDB" id="1134430at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01389">
        <property type="entry name" value="UreG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004400">
        <property type="entry name" value="UreG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31715">
        <property type="entry name" value="PTHR31715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00101">
        <property type="entry name" value="ureG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 4" id="KW-0996">Nickel insertion</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="cobW" evidence="5">
        <location>
            <begin position="46"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="50"/>
            <end position="57"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH80870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="243" mass="25868" checksum="DBE7C4F09B212B90" modified="2015-07-22" version="1">MHRDHPETTPQRYSYGTAARRLGTLPAPAGPAGSAIRATPRRALRVGLGGPVGSGKTAIVAALCRLMRDELALAVVTNDIYTREDAEFLLREAVLPPERITAVQTGACPHTAIRDDISANVEAVEELEATVGPLDVVLVESGGDNLTATFSRGLADVQLFVIDVAGGDDIPRKGGPGVTMADLLVVNKVDLAPHVGSDLRRMARDARTQRGEKPVVFTSLAREGGVRPVADWLRERVAAWRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MYJ0</accession>
    <name>A0A0F7MYJ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_02900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014658.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_02900"/>
    <dbReference type="EnsemblBacteria" id="AKH81295">
        <property type="protein sequence ID" value="AKH81295"/>
        <property type="gene ID" value="AA958_02900"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_02900"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.620"/>
    <dbReference type="OrthoDB" id="1437290at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="8"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH81295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="199" mass="21962" checksum="81BAC1529BEE0C41" modified="2015-07-22" version="1">MKSKRHKPSLDDLALDALRDCVLAVGVRRTTLTDVARRAGVSRMTLYRRWPDVQSLVGDLMTREWIGVARGALPAADGAANAREVLVAGLTEGSRALRAHPLFRKILDVDPELLLPYMLDRRGASQDVLLDLIAEDVRKGHADGSVREGHAVRQARAALLVVQSFTFSMRTMTDEDDPDLGTAAFEHELRGVLERMLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MYS9</accession>
    <name>A0A0F7MYS9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Uroporphyrin-III C-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">AA958_03490</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>NAD(+) + precorrin-2 = 2 H(+) + NADH + sirohydrochlorin</text>
            <dbReference type="Rhea" id="RHEA:15613"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58351"/>
            <dbReference type="ChEBI" id="CHEBI:58827"/>
            <dbReference type="EC" id="1.3.1.76"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Porphyrin-containing compound metabolism; siroheme biosynthesis; sirohydrochlorin from precorrin-2: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014758.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_03490"/>
    <dbReference type="EnsemblBacteria" id="AKH81400">
        <property type="protein sequence ID" value="AKH81400"/>
        <property type="gene ID" value="AA958_03490"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_03490"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.737"/>
    <dbReference type="OrthoDB" id="1185397at2"/>
    <dbReference type="UniPathway" id="UPA00262">
        <property type="reaction ID" value="UER00222"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043115">
        <property type="term" value="F:precorrin-2 dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051266">
        <property type="term" value="F:sirohydrochlorin ferrochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004851">
        <property type="term" value="F:uroporphyrin-III C-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019354">
        <property type="term" value="P:siroheme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd11642">
        <property type="entry name" value="SUMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006366">
        <property type="entry name" value="CobA/CysG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012409">
        <property type="entry name" value="Sirohaem_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006367">
        <property type="entry name" value="Sirohaem_synthase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003043">
        <property type="entry name" value="Uropor_MeTrfase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036426">
        <property type="entry name" value="Sirohaem_synth"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01469">
        <property type="entry name" value="cobA_cysG_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01470">
        <property type="entry name" value="cysG_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00840">
        <property type="entry name" value="SUMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 14 17" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 14 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="16">
        <location>
            <begin position="190"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="160"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="220"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="13">
        <location>
            <position position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR036426-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AKH81400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="427" mass="43783" checksum="04DB5BF5C37B0837" modified="2015-07-22" version="1">MSRPPAHSAPGSDTFAYPVGLRLAGRRVVVLGGGQVAQRRLPALLAAGARVTLVSPSATPSVEAMADAGELTWERRPYADGDLEGAWYAVVATRDPAANAAASAEAERRRVWCVRSDDASAATAWTPATGRSEGVTVAVLTGSDPRRSAAVRDAVVEGLRDGTLSAPRHRTLPQGPPTSSGPGGTPVPGVALVGGGPGDPDLITVRGRRLLAEADVVIADRLGPRDLLDELPPHVEVIDAAKIPYGRAMAQEAINDALIRHARAGKAVVRLKGGDPFVFGRGMEEAEALARAGVACTVVPGVTSAISVPAAAGIPVTHRGVAHEFTVVSGHVAPGDERSLVDWPALARLRGTLVLLMAVERIGAIAETLVREGRDPATPVAIVQEGTTAAQRRVDAALGTAAAAVAREGVRPPAVIVVGEVAARSPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MYZ6</accession>
    <name>A0A0F7MYZ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_00805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH80946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH80946">
        <property type="protein sequence ID" value="AKH80946"/>
        <property type="gene ID" value="AA958_00805"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_00805"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.181"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH80946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="56" mass="5710" checksum="044920BD7F456ED0" modified="2015-07-22" version="1">MAKPGSAKTMVVSTVAGLVVITAYTVSVGSSGWLWFGWVILGLAALGVVLTGGSWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MZ77</accession>
    <name>A0A0F7MZ77_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_04615</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014950.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH81595">
        <property type="protein sequence ID" value="AKH81595"/>
        <property type="gene ID" value="AA958_04615"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_04615"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.973"/>
    <dbReference type="OrthoDB" id="1570162at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004111">
        <property type="entry name" value="Repressor_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02909">
        <property type="entry name" value="TetR_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="34"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH81595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="251" mass="27000" checksum="1DE6E6DDA2EC66C0" modified="2015-07-22" version="1">MAASGRAADGTARGAAPEVIWTRPERAGRGPRPAHSRAAIAAAAVRIADADGLDAVSMRRVAAEIGSGTMSLYNYVPRKEDLHELMVDAVSAEYDLSVPLTGDWRADVLALAEQSRDLMRRHPWLPRLTSTTAYGFTPHALRYLDRFLAALAGLDVPPGTKMELVAMVTASVTSYVTFEIALAERARALPWTEAEEEAVRGAYLARQLATGEYPHLAATLAQAPQPGDHEAAFRRLLGRVLDGFEPSGGPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MZC0</accession>
    <name>A0A0F7MZC0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_01520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_01520"/>
    <dbReference type="EnsemblBacteria" id="AKH81061">
        <property type="protein sequence ID" value="AKH81061"/>
        <property type="gene ID" value="AA958_01520"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_01520"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.334"/>
    <dbReference type="OrthoDB" id="2031580at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046041">
        <property type="entry name" value="DUF5999"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19462">
        <property type="entry name" value="DUF5999"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="68" mass="7321" checksum="9D28C4617CE9FA66" modified="2015-07-22" version="1">MCQHQPPCPTAQSTDREAARPVAHHPEQGWSLLCNGVLLFEDTGELLPDGRIIAPHRPPNADDVTAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MZX0</accession>
    <name>A0A0F7MZX0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sugar ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_06110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015203.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_06110"/>
    <dbReference type="EnsemblBacteria" id="AKH81850">
        <property type="protein sequence ID" value="AKH81850"/>
        <property type="gene ID" value="AA958_06110"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_06110"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1276"/>
    <dbReference type="OrthoDB" id="447734at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519091" evidence="1">
        <location>
            <begin position="22"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="433" mass="46655" checksum="35D8D4E62388C8D6" modified="2015-07-22" version="1">MRKFVIGAVSAAMVLGLAACGSDSDDGDGGGDALDGKGKTLDVWIMKGTNPDAEPFFDKLNKEFEKKTGAKVNVEYQQWESAQRKFTTAIEGGPDQVPDVAEVGTTWVPQFADTGGLVDVTDQVKDAGLDQDLVEGLKDAGTLEGKQYGMPWYAGVRGLVYRKDIFDKHGLKAPTTWEELRDVALTLKKEEPDMISFPVAGGAEMFAMPFVWGAGGEPAVQDGDTWKSAINSPESVEGLQFYTDLATKDKLSPAKVTTWREDEVAQEFTKGNVAMTISGNWTPKTFLDEAPELEGKIAAAPIPGKDGGMSPSFLGGSYLSTFDSDKKELAWEYVKMATTGKFAAEWAKQTNYFPGTNTDLKKIADEGDPLVEPFAKQMMEAGATVPKTTAYGEIQASQVVLKLVQSVLKGDQSVQEAADKAAGEMDDIFAKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N027</accession>
    <name>A0A0F7N027_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Purine nucleoside phosphorylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AA958_06515</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>adenosine + H(+) + H2O = inosine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:24408"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:17596"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:24409"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>adenosine + phosphate = adenine + alpha-D-ribose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:27642"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57720"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="2">
            <dbReference type="Rhea" id="RHEA:27643"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>inosine + phosphate = alpha-D-ribose 1-phosphate + hypoxanthine</text>
            <dbReference type="Rhea" id="RHEA:27646"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:17596"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57720"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:27647"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>phosphate + S-methyl-5'-thioadenosine = adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11852"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58533"/>
            <dbReference type="EC" id="2.4.2.28"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:11853"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="5 9">Belongs to the purine nucleoside phosphorylase YfiH/LACC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_06515"/>
    <dbReference type="EnsemblBacteria" id="AKH81920">
        <property type="protein sequence ID" value="AKH81920"/>
        <property type="gene ID" value="AA958_06515"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_06515"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1360"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004000">
        <property type="term" value="F:adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017061">
        <property type="term" value="F:S-methyl-5-thioadenosine phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd16833">
        <property type="entry name" value="YfiH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.140.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003730">
        <property type="entry name" value="Cu_polyphenol_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038371">
        <property type="entry name" value="Cu_polyphenol_OxRdtase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011324">
        <property type="entry name" value="Cytotoxic_necrot_fac-like_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30616">
        <property type="entry name" value="PTHR30616"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02578">
        <property type="entry name" value="Cu-oxidase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64438">
        <property type="entry name" value="SSF64438"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00726">
        <property type="entry name" value="TIGR00726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AKH81920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="224" mass="22644" checksum="972D775BBFC19CB8" modified="2015-07-22" version="1">MSAAPYAELNLGGAVGADDPAAVAVNRERAARSLGVEPARVVWMHQVHGRDVAVVDGPWGDAPPPAVDAVVTRARDVPLAARGADCVPLLLADPGAGVAGAAHAGRPGMVAGVAGAAVEAMVGLGAEPARIVAHLGPAVCGRCYEVPEALREEAAGRVPAARATTSWGTPALDIRAGVVAQLEALGVGMITVSDVCTLESGDHFSYRREGATGRHAGYVWLDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N031</accession>
    <name>A0A0F7N031_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_03015</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014679.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_03015"/>
    <dbReference type="EnsemblBacteria" id="AKH81316">
        <property type="protein sequence ID" value="AKH81316"/>
        <property type="gene ID" value="AA958_03015"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_03015"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.643"/>
    <dbReference type="OrthoDB" id="1688736at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="283"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="92"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH81316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="316" mass="34457" checksum="23744601BF29467E" modified="2015-07-22" version="1">MSTSVKPGRARSGTAGRGRRGGRPDRKAWAFLGPFLALYLFAMVVPVLYAVYQSMLKVERSGPMGLGEPSVGFAGFENYSLALQQETFVDGFGRVLLFGIVQVPVMLLLALVLALLLDQVSHRWAGLLRATYFLPYGIPGVVATILWGFLYVPGVSPITSVLGDLGFQPDFLGYDSVLWSIANIVVWQFAGYNMLIIIAQLKSVPQELYEAARIDGAGPWQTALRIKIPLVRPALVLTTVFSIIGTMQLFAEPLVLKKVAPAVTTDYTPNLSAYFDAFANANLYLAAAKSVILAVVAMVLSFGFLSLVTRRQRSER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0F0</accession>
    <name>A0A0F7N0F0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH gntR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_00395</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH80878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014244.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_00395"/>
    <dbReference type="EnsemblBacteria" id="AKH80878">
        <property type="protein sequence ID" value="AKH80878"/>
        <property type="gene ID" value="AA958_00395"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_00395"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.94"/>
    <dbReference type="OrthoDB" id="1911275at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="9"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH80878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="220" mass="24581" checksum="2A1438B8C5BABE97" modified="2015-07-22" version="1">MQHNKPTPPSKADQVYEALLEQIGTGTLAPGVRLSEREMVERYGASRTTVRAAAARLIHEGLLERTTRGMLIQERPREQILQVYDAWALLEAAAVEQAAQAATETDLKELERLLTGHRRHDGGQGHRPDLHLKFHEALWDASHNPVLVGLLLSLNTRLLQVATSTLAQPGRWQVALDEHGKILTALRAGRGPEAAGLARDHILSAREARLEMWRNEHRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0N4</accession>
    <name>A0A0F7N0N4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_08080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015545.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_08080"/>
    <dbReference type="EnsemblBacteria" id="AKH82195">
        <property type="protein sequence ID" value="AKH82195"/>
        <property type="gene ID" value="AA958_08080"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_08080"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1703"/>
    <dbReference type="OrthoDB" id="840225at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="423" mass="46370" checksum="23A95D8E83AE9444" modified="2015-07-22" version="1">MAFGGGGGGTRRWGWGDRGDGARAEAQAAKDAAATAFYELDTAERDLRISVETIAAVDDSPAARKATADFAALGRRIDEVSHTYISAVDSYDLDRDDLDHGTASRARHELQQATNGLEKVRSDLNHFAHGLGPLLDQAESQLARLAPAVERARQALLAATTALDEVRAKGFRADDLAARLAGLGPELTKLNEGAGRHGVQETIHRAVGVQRDAEALRSEAEQLPQRAEEIDRRLVSLRTRAQALATRAEKVKPVLSELRRRFALACWRDLQEVPDRAAQAVTEAEEKIADASRARREQRWPDAIALLASVRALLNQTDEAVDATRDRLHRLDAVEKDRASEVNRTRFAIRDAQRLAMAGRDRPDPRHAGPLDAAVERVDRAEAALTGRHPDYWSFLEELEAVRETVAEVVQAIRAERGAGTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0R2</accession>
    <name>A0A0F7N0R2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_01075</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH80993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014359.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH80993">
        <property type="protein sequence ID" value="AKH80993"/>
        <property type="gene ID" value="AA958_01075"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_01075"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.236"/>
    <dbReference type="OrthoDB" id="1261526at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH80993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="223" mass="22892" checksum="BAEF817C7FA17CDA" modified="2015-07-22" version="1">MPVLAVIGAGPGLGLSIARRFGREGFQVALVSRTQDKLDALAAQLADEGIEAAGFAADVTRPDSLQSALAAVADRFGAVDLLEYSPADPTFAGAAAVDATAQDLHKQLDYYLYGAVAAVRQVLPAMLERGSGTLLFTTGASSVRPLGGAFGSVGVAAAALRNYAMALGVDLAESGVHAAHVAIGVFIGSGPGTEPETIAEHYWDAYTKRDQAEIVHTVPGGIW</sequence>
</entry>
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
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    <dbReference type="PATRIC" id="fig|444103.5.peg.269"/>
    <dbReference type="Proteomes" id="UP000034283">
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        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
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            <begin position="34"/>
            <end position="165"/>
        </location>
    </feature>
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        <location>
            <begin position="34"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH81014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="165" mass="15845" checksum="104F275CD5BF77FD" modified="2015-07-22" version="1">MHPTHAAGALLTGLTTLAAVAGCVTVSPVPATGSGTGARHGPGAGSPATAAPAPAASPLPGRDELATIGPVPRPRRTSAAPAPAPSAGAARPDVSAPGDGLPPAPETPAPRTGQGRPARTAQPAPPPRTPAASGGAVDLCGLAGDYGRWAPGSREDAACAEYLER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0Y1</accession>
    <name>A0A0F7N0Y1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">AA958_04985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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    <dbReference type="EnsemblBacteria" id="AKH81656">
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        <property type="gene ID" value="AA958_04985"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_04985"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1048"/>
    <dbReference type="OrthoDB" id="2066171at2"/>
    <dbReference type="Proteomes" id="UP000034283">
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="181" mass="18691" checksum="ADB5346547296193" modified="2015-07-22" version="1">MSEPTPMPAAQPETATAPPYVRQPAAQWPEPGGGDVADAAESAGPPARTATGPEGERRPEAEPEPEPDAVEPEPVEAGPVPLGIARTPTGNADVDAALDRLADADELPTGSHLEVYEDAHGRMREALEELDRTQGPPPPPVQAPAGPAAYAQQHRPGPPPPAPHGPTPPRPGAHPYRPGNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0Z8</accession>
    <name>A0A0F7N0Z8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="13">ABC transporter ATPase</fullName>
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    </protein>
    <gene>
        <name evidence="13" type="ORF">AA958_05085</name>
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    <organism evidence="13 14">
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        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
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    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
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                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="13 14">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AKH81671">
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        <property type="gene ID" value="AA958_05085"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_05085"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1065"/>
    <dbReference type="Proteomes" id="UP000034283">
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    </dbReference>
    <dbReference type="GO" id="GO:0016021">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SSF49879"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <location>
            <begin position="571"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="610"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
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            <end position="678"/>
        </location>
    </feature>
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            <end position="720"/>
        </location>
    </feature>
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        </location>
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            <end position="819"/>
        </location>
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            <end position="40"/>
        </location>
    </feature>
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            <end position="226"/>
        </location>
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            <begin position="258"/>
            <end position="499"/>
        </location>
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            <end position="165"/>
        </location>
    </feature>
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            <end position="127"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
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            <end position="305"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="828" mass="89393" checksum="32139F1311D49325" modified="2015-07-22" version="1">MVLEDARVSWRHASLRWGGRSWLLEDVGSTNGSYVEGQRVHQIEVGPGSVVYLGNATDGPQLRLSAPAGAAAPDVYSAQTAMAQPPPGAHQAAPPQQAPGAWGAPPQGPPPQGPPFQGPPAGMPPQQQPYVPQQQSAPQRPPAAAGAGHGGGPGAPSVYGDRSPTTFHQLSLGRVTRIGRALENELVVSDLQVSRHHAEFRSTPDGRSEIVDLGSHNGTYVNGEQLPQRGRRPIGPDDIIGIGHSTFRLVGDRLEEFVDTGEVSFSARHLTVKVDGGKVILDNVSFGVPEKSLIAVIGPSGSGKSTLLKALTGYRPADVGEVLYDNRNLYKQFAELRHRIGLVPQDDILHTQLTVTRALRYAAKLRFPGDTAEAERAARVDEVLRELKLDIHKEKRISSLSGGQRKRVSVALELLTKPSLIFLDEPTSGLDPGMDRDVMQLLRGLADDGRTVLVVTHSVAELALCDRLLVMAPGGGVAYFGPPEEALNFFGYETWADIFSAFENYREYDWKGRWQGSQHYQMYAADIDAVAPQPVAMQPPQMLRPSKPQGWGPQLWTLVRRYVSVLASDRFFIALTIILPVVLGVVSMVIPAEFGLGYGPAKIHLINRAAGTILLILAVGACFSGAANSVRELIKERVIYERERAVGLSRSAYVMSKVLVLGIITIFQGAVISAIGVLSRSKLPEEGVILSDLPAVELAIGVTTLGLTSMMFGLIISALVKTSEMTMPLLVMFAIVQVVFTGVLFQLHGTPGVEQLAWLMPSRWAVAAMGSTSDLNVLLPWDSGETDALWEHTAGTYLLNIGVLLTMGVICGFIVARLLRKHEPEVMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N1D4</accession>
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    </gene>
    <organism evidence="4 5">
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        <lineage>
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    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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    <dbReference type="EnsemblBacteria" id="AKH82350">
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    </dbReference>
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    <dbReference type="OrthoDB" id="1155703at2"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519681" description="F5/8 type C domain-containing protein" evidence="2">
        <location>
            <begin position="28"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="3">
        <location>
            <begin position="12"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH82350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="431" mass="45177" checksum="FEF94029D4106313" modified="2015-07-22" version="1">MRRMLTAALCACTAVGSVALLAPAASAATLPISAATASSHDGNVPANAIDGDLSTRWSGAGDGVWIRFDLGSVTTVDSVALAWYVGDSRRSTFDVQLSQDGSTWSTVLSRETSSGTTRSLETYDFAEGSARYVRIVGHGNDSSDSSKWTSITEAAVSGEPGGDPQPPGQSLGVGGVATPPGAILVPDRDSRFEIESGGTSAAPKVYDCQGNTIRGGVLIDADHVVIQNCRVDAEQQYGIYSDDNTDVTIQNNDIKGVEGPGDLNAVTFFGNRHKILYNTAVDFVTGDPGDSHTDFIQTWVSSSHPIASDDVQIRGNKAVGPANPDRENSVPSIHQWLMVEDYGRGGNSGGNTDGMKNWIVADNEMGDSWNQSIKLDGPDDVSITRNDFTGSSTRVMEVTSASTGVRFYGDNHVGPDYGSVGMTITPGAGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-10-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N1K4</accession>
    <name>A0A0F7N1K4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_06225</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015224.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH81871">
        <property type="protein sequence ID" value="AKH81871"/>
        <property type="gene ID" value="AA958_06225"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_06225"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1302"/>
    <dbReference type="OrthoDB" id="990666at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH81871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="302" mass="32312" checksum="F13554681AD0B8E9" modified="2015-07-22" version="1">MHLQQLRYFAAVADTRHFTRAAEREHVAQPSLSQSVRALERELGAELFHRARGHITLTDAGEALLPLARRILADTETARREVQEVAHLRRGRVRLGATPSLCASLVPDALRAFHARYPGIELHVHEDGSQDLVRTLAAGELDLALVITPLAGQAPALTTTELLREELVVVSSPDAPPVTSADGAGRGIRIGDLRGRPLAMFRHGYDLRELTVAACREAGFEPEFGVEGGEMDAVLGFVRAGLGVAVVPSMVAERSGLRTTAFAAPGLHRTISVAHRGDVSPPRAARELRRLLISAAGGGSGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N1W3</accession>
    <name>A0A0F7N1W3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NlpC/P60 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_06785</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015318.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_06785"/>
    <dbReference type="EnsemblBacteria" id="AKH81966">
        <property type="protein sequence ID" value="AKH81966"/>
        <property type="gene ID" value="AA958_06785"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_06785"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1419"/>
    <dbReference type="OrthoDB" id="682655at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519073" description="NlpC/P60 domain-containing protein" evidence="4">
        <location>
            <begin position="36"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="NlpC/P60" evidence="5">
        <location>
            <begin position="225"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="141"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH81966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="340" mass="36803" checksum="83D62FC87042F3D8" modified="2015-07-22" version="1">MASHRRPKQPNRARVTVFTATAAAAVALSTQSAQAAPDKDDVKRQVDNLYEDAERATEKYNGAKERQDKLEEDVKELQDKAARGQQELNDLRDGLGSLATAQYRSGSIDPSVQLFLSADPDTYLDKASTMDRVSGKQAESLERIADKQRSLAQQRQEASAKLKDLEETRKELGSQKKKVQDKLSDARALLNQLTEEEQAALAEEEQRASREAEDRVDLGDVAPGSSHGAAALSAAQSKLGAPYVYGATGPSSFDCSGLTGWAFSQAGVALPRISQDQANVGTRISSVSQLQPGDLVFFYSDLHHVGIYAGNGQIIHAPKPGAVVRYEAVGNMPFMWGARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N283</accession>
    <name>A0A0F7N283_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_11250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016048.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_11250"/>
    <dbReference type="EnsemblBacteria" id="AKH82710">
        <property type="protein sequence ID" value="AKH82710"/>
        <property type="gene ID" value="AA958_11250"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_11250"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2371"/>
    <dbReference type="OrthoDB" id="1943830at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH82710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="170" mass="17405" checksum="752D9638F2386090" modified="2015-07-22" version="1">MRVYVPLTLPGLARAHEAGELGPAPLVAYAVTPALREWYVSDNLEELEYAALTRAAQASLRLLAIAPAPGAPPRRVVVAVELPESAAAADPDRGMDPAAIGEVRVAAAVPLKLAAAVHVDADDAAADVAAAVAALGAADAGDDDARFTVDGAEDHELLWYGVQEIGNLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2Q3</accession>
    <name>A0A0F7N2Q3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Molybdenum cofactor synthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_12335</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016225.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_12335"/>
    <dbReference type="EnsemblBacteria" id="AKH82890">
        <property type="protein sequence ID" value="AKH82890"/>
        <property type="gene ID" value="AA958_12335"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_12335"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2592"/>
    <dbReference type="OrthoDB" id="1877633at2"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00886">
        <property type="entry name" value="MogA_MoaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008284">
        <property type="entry name" value="MoCF_biosynth_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="SSF53218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00177">
        <property type="entry name" value="molyb_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01078">
        <property type="entry name" value="MOCF_BIOSYNTHESIS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MoCF_biosynth" evidence="4">
        <location>
            <begin position="4"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="151"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH82890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="188" mass="19043" checksum="3EF152F036658EBE" modified="2015-07-22" version="1">MRALAVTVSNRAAAGVYADTGGPLLVAGLTEMGFAADGPLVVPDGEPVEAALREAVAAGYDVVLTTGGTGVSPTDRTPEMTARVLDRQLPGVPEAIRAYGYAKVPTAALSRGLAGVADRTVIVNLPGSSGGVRDGLAVLARLLPHAVDQVHGGDHARAEDGPRGDDGPRAEDAPRADDGRHRHPGGAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2U5</accession>
    <name>A0A0F7N2U5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_05225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018835772.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_05225"/>
    <dbReference type="EnsemblBacteria" id="AKH81698">
        <property type="protein sequence ID" value="AKH81698"/>
        <property type="gene ID" value="AA958_05225"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_05225"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1097"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="64" mass="6737" checksum="1C9ADD8811E7F72F" modified="2015-07-22" version="1">MSMAVVGLIAGMALGFAGYFGGFGAFLLVAALGAIGFVVGRVLDGDLEPGDFFRRPGERDDRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N322</accession>
    <name>A0A0F7N322_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_13305</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. RAD25/XPB subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="2"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016376.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_13305"/>
    <dbReference type="EnsemblBacteria" id="AKH83045">
        <property type="protein sequence ID" value="AKH83045"/>
        <property type="gene ID" value="AA958_13305"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_13305"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2799"/>
    <dbReference type="OrthoDB" id="377818at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032438">
        <property type="entry name" value="ERCC3_RAD25_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032830">
        <property type="entry name" value="XPB/Ssl2_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16203">
        <property type="entry name" value="ERCC3_RAD25_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13625">
        <property type="entry name" value="Helicase_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="188"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="396"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH83045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="548" mass="60741" checksum="6E2FE464A351C146" modified="2015-07-22" version="1">MSCLIVQSDKTLLLEVDHELAGECRRAIAPFAELERAPEHIHTYRVTPLGLWNARAAGHDAEQVVDALVTYSRYPVPHALLVDIAETMARYGRLTLTKDPAHGLVLSTTDRPVLEEILRSKRIQPLVGARLDDDTVAVHPSERGQIKQALLKLGWPAEDLAGYVDGEAHPIALVEEGWGLRPYQKQAVEGFWHGGSGVVVLPCGAGKTLVGAGAMAEAQATTLILVTNTVAARQWKSELLRRTSLTEHEIGEYSGARKEIRPVTIATYQVLTTRRKGVYPHLELFDSRDWGLIVYDEVHLLPAPVFKFTADLQARRRLGLTATLVREDGRESDVFSLIGPKRFDAPWKEIEAQGYIAPADCVEVRVNLTDAERLAYATAEAEEKYRFCATTDTKRKIAEALVARHTGEQTLVIGQYIDQLDELGEHLDAPVIKGETTNARREKLFDAFRSGEISVLVVSKVANFSVDLPEATVAIQVSGTFGSRQEEAQRLGRVLRPKEDGHEARFYSLVARDTIDQDFAAHRQRFLAEQGYAYRIVDADDVLAGDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N380</accession>
    <name>A0A0F7N380_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_02995</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014675.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_02995"/>
    <dbReference type="EnsemblBacteria" id="AKH81312">
        <property type="protein sequence ID" value="AKH81312"/>
        <property type="gene ID" value="AA958_02995"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_02995"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.639"/>
    <dbReference type="OrthoDB" id="1045165at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="5">
        <location>
            <begin position="7"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="242"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH81312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="270" mass="27828" checksum="86314CBFE017393B" modified="2015-07-22" version="1">MAGYARRGVHGQTVETLAHRVLGGEIAEGATLDLAALQAELGVSLTALRESLKVLAAKGMVDARQKRGTFVRPRADWHLLDADVLRWRFETAGRQQGEGAAARAASPLLRDLDEVRGIVEPAAVRLAAVRRTDADLAALEAALTAMAGARDGAAEAVAADLAFHRALLAASHNELLERMDQVLASGLAARDRLVHGPGHHPSDPVPGHRAVLAAIRAQDPDAAEAAMHRLLAQAARDLAELSAGEPGAGSAEGSAAEPAGGSAAERAAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N386</accession>
    <name>A0A0F7N386_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_13715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_027772341.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH83115">
        <property type="protein sequence ID" value="AKH83115"/>
        <property type="gene ID" value="AA958_13715"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_13715"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2887"/>
    <dbReference type="OrthoDB" id="2102568at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="71" mass="7243" checksum="643920C9680158D3" modified="2015-07-22" version="1">MPVGITLAMSALLVGFERFVEWRFGAVGAIGLTTLLVGLKAQNVTCMTIGGLALAVLLLQSAEPGRAAAGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3B7</accession>
    <name>A0A0F7N3B7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">YceI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_10140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015868.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_10140"/>
    <dbReference type="EnsemblBacteria" id="AKH82526">
        <property type="protein sequence ID" value="AKH82526"/>
        <property type="gene ID" value="AA958_10140"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_10140"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2135"/>
    <dbReference type="OrthoDB" id="1767227at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007372">
        <property type="entry name" value="Lipid/polyisoprenoid-bd_YceI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036761">
        <property type="entry name" value="TTHA0802/YceI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04264">
        <property type="entry name" value="YceI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00867">
        <property type="entry name" value="YceI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101874">
        <property type="entry name" value="SSF101874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YceI" evidence="1">
        <location>
            <begin position="15"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="181" mass="19677" checksum="B0AB274E0604292A" modified="2015-07-22" version="1">MTTHADRIPAYQTGTWTIDPVHSDVSFVVRHLGVTRVRGTFDHVEGTIVTHEDPLQSEVTAVIRTTSVNTRNDMRDDHVRTADFLDVETYPEMTFKSTGIRVKDDVYLIDGDLTLRGVTRPVTLETEVGGFGPGMQEGHTVVGFSATTEINRSDFGVTGGAAGAAVSDKIKITLDIEAGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3D7</accession>
    <name>A0A0F7N3D7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acetyl-CoA acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_06345</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015242.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_06345"/>
    <dbReference type="EnsemblBacteria" id="AKH81889">
        <property type="protein sequence ID" value="AKH81889"/>
        <property type="gene ID" value="AA958_06345"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_06345"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1325"/>
    <dbReference type="OrthoDB" id="550338at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="3">
        <location>
            <begin position="6"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="4">
        <location>
            <begin position="267"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="1">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="345"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH81889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="390" mass="40449" checksum="7A2DD656A990665C" modified="2015-07-22" version="1">MTTTAVVVDAVRTASGKGKPGGALSGVHSVDLLAEVLRALVDRNGLDPARLDDVIAGCVTQAADQSFNIARNAVLAAGFPESVPGTTVDRQCGSSQQAAHFAAQGVMAGAYDIAVAAGVESMSRVPMGTAAVGRDPFGDRLAARYPGGLIAQGHSAELIAARWGLGRTELDAFSERSHRLAVRAWERGVFDADVVPVGEHRKDETVRPSTSLDGLAALKPSFYDPAVAERFPEIGWHITPGNSSPLTDGASAVLITSEERAAELGLTPRARFHSFAVTGDDPVLMLMGVVPATRKVLAKAGLTIGDIDAFEVNEAFAPVPLAWQRDVGADPERVNVHGGAIALGHALGASGTRLLGTLLGALDAVDGRYGLQVMCEAGGLANATIVERLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-10-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3Y5</accession>
    <name>A0A0F7N3Y5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_15175</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016649.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH83335">
        <property type="protein sequence ID" value="AKH83335"/>
        <property type="gene ID" value="AA958_15175"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_15175"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3197"/>
    <dbReference type="OrthoDB" id="990666at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH83335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="301" mass="32003" checksum="DB89338FCE35D8AE" modified="2015-07-22" version="1">MELQQLRYVVAVADTGGFTRAAERCHVVQSALSHQIGKLERELGARLFDRTSRQVRPTRAGEAFLPAARATLAAAERARAEVAAATGEVRGRLAIGSIPTVAAVNLPAALKEFHDTYPQVRISLAVGASEHLVRAVAEGTYDLALLGVPAGFRADKIRERILVRDRHLAVLPPDHPLAGTDETDLARLAEETFVDFAAGTAARAQSEEAFAAAGLRRTVGFEVSSMDFMADLVRAGLGVALLPSTFAPRLPGLATVRIADGPSREERLIWPRTRPSPAAAAFLHSLGVTPGEDDDGDTPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4A4</accession>
    <name>A0A0F7N4A4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phosphoribosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_08105</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_08105"/>
    <dbReference type="EnsemblBacteria" id="AKH82199">
        <property type="protein sequence ID" value="AKH82199"/>
        <property type="gene ID" value="AA958_08105"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_08105"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1708"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028157">
        <property type="entry name" value="PELOTA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011215">
        <property type="entry name" value="PRTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041688">
        <property type="entry name" value="PRTase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022537">
        <property type="entry name" value="TRSP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15608">
        <property type="entry name" value="PELOTA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11202">
        <property type="entry name" value="PRTase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15609">
        <property type="entry name" value="PRTase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12500">
        <property type="entry name" value="TRSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PRTase_2" evidence="4">
        <location>
            <begin position="18"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="TRSP" evidence="2">
        <location>
            <begin position="395"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="domain" description="PELOTA_1" evidence="3">
        <location>
            <begin position="854"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF15608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF15609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH82199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="965" mass="98320" checksum="04E973EADAD4C071" modified="2015-07-22" version="1">MESRLGVELSGPAELRDLVGLALRRNPRRAHLLVSTVLGKHVPQRPSRIHGAGLRLGGLARDLLGPGAAARAVVLGYAETATGLGHCVADGLGASAYLHSTRRAVPGVRRAAGFEEEHSHATEHLLLPADPGLLTGEGPLVLVDDELSTGRTLRNTIAALHAARPRARYVVAALTDMRPEEDRRALEKSAADLGTRVDVVSLTSGTVRLPPDVLRRGAELVAQHEPPAAGTAGPAGGGPDAAGDVPGGSSGGAVVAGAAGGRGPVTGSAGAAGQEHEAPVAEAVPAAWDPAATGPAEVARPGPADAEGRAAGVAAPGAVGGQAAGRSAPPPAGTSSASGTSSASGTSSASGSSSASGGAGGSGAERPGFGKGRGRGTIAAAVRRVALGWPAGLPDGGRHGFGSGHRTRLESALPGMAGRVAGALGLPAAPAEPPRLLVLGTEELMYAPLRLATALEDLLPGADVRFSSTTRSPVLPVDHPGYAIRSRLTFPAHDTHDTPGAHGGTRYAYNVTGDDAYDAVVVVTDSAADTPALHAPGGLLDVLAAHTDRVLLAVIPSYAPPAESGTEAGAGPGAAAPAEPLRGPAFSSYAPDEVGWLLKDLSDVALEAPTEEREEAIQRGGAHYAESLPVEYQPSPDYVRLFHSALDATAGRIADAVATVTETVLAERSPAPVLVSLARAGTPVGILMRRWARHAHGLDLPHYAVSIVRGRGIDTAALRRLAAHHDPADVVFVDGWTGKGAIARELAAALRDFPGFDPRLAVLADPGRCVDTYGTREDFLIPSACLNSTVSGLISRTVLRADLIGPADYHGAKFYRELAGDDLSGHFLDAVTARFPAPAAVRPMPAAAEREPTWAGWAAVERISEAYGIGDVNLVKPGVGETTRVMLRRVPWRVLARRGAGADLDHVRLLAEQRGVPVEETDDLPYTCVGLIHPRYTRGATGADGTAAAAAPGAALPDVPGAPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4A7</accession>
    <name>A0A0F7N4A7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PadR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_16110</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016789.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_16110"/>
    <dbReference type="EnsemblBacteria" id="AKH83480">
        <property type="protein sequence ID" value="AKH83480"/>
        <property type="gene ID" value="AA958_16110"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_16110"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3395"/>
    <dbReference type="OrthoDB" id="1706427at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="3">
        <location>
            <begin position="12"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="182"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="126"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="204"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH83480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="220" mass="25005" checksum="0BF9AB8E03DD8318" modified="2015-07-22" version="1">MSRRSGILEFAILGLLRESPMHGYELRKRLNSSLGVFRAFSYGSLYPCLKTLVAQGWLTEETAPAPQDGPAVPLAGRRAKIVYRLTAEGKEHFEELLAQTGPEAWEDEHFGVRFAFFGQTSRDVRVRVLEGRRSRLEERLDKMRTSLARTRERLDDYTLELQRHGMESVEREVRWLTELIESERAGRDERPSGNAGSAETGGLPRDRDSTRPDPSDDTAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4A9</accession>
    <name>A0A0F7N4A9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_08215</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015568.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_08215"/>
    <dbReference type="EnsemblBacteria" id="AKH82218">
        <property type="protein sequence ID" value="AKH82218"/>
        <property type="gene ID" value="AA958_08215"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_08215"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1733"/>
    <dbReference type="OrthoDB" id="972769at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ADH_N" evidence="4">
        <location>
            <begin position="28"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="ADH_zinc_N" evidence="3">
        <location>
            <begin position="179"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH82218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="338" mass="33942" checksum="BB8E08F7EEA5089D" modified="2015-07-22" version="1">MAESHRAVVLHEPGRARVGSVASSPPGPGEVRVRVYAAGVCGSDREVYDGTRPAGYVTYPLTPGHEWSGTVAEVGPGADAALAGRRVVAEGFRCCQVCARCRSGETNLCAGPYDETGFTRAGAFAETVTVPARLLHVLDDDADLRAAALLEPAAVAAAAVLRGAPLPGERVAVVGGGTLGLLAVQLLAGYAPAELLVVEPRAERAEAARGFGARAVAPGAAGGLAGAYDMVVETAGAERSAAAAVELVRRGGRVVVAGIPPGGAAGVDPVALAMRQIAVYGVFGASSAAWSYAVRAFGAGQLDPAALITHELPLDAYEKAVGLVGGGDPAVGKVLLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4M0</accession>
    <name>A0A0F7N4M0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pseudouridine-5'-phosphate glycosidase</fullName>
            <shortName evidence="6">PsiMP glycosidase</shortName>
            <ecNumber evidence="6">4.2.1.70</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">psuG</name>
        <name evidence="7" type="ORF">AA958_05815</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible cleavage of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil. Functions biologically in the cleavage direction, as part of a pseudouridine degradation pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>D-ribose 5-phosphate + uracil = H2O + psi-UMP</text>
            <dbReference type="Rhea" id="RHEA:18337"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17568"/>
            <dbReference type="ChEBI" id="CHEBI:58380"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="EC" id="4.2.1.70"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="6">Binds 1 Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the pseudouridine-5'-phosphate glycosidase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.70" evidence="6"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015150.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_05815"/>
    <dbReference type="EnsemblBacteria" id="AKH81797">
        <property type="protein sequence ID" value="AKH81797"/>
        <property type="gene ID" value="AA958_05815"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_05815"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1217"/>
    <dbReference type="OrthoDB" id="1294333at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004730">
        <property type="term" value="F:pseudouridylate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046113">
        <property type="term" value="P:nucleobase catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1790.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01876">
        <property type="entry name" value="PsiMP_glycosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022830">
        <property type="entry name" value="Indigdn_synthA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007342">
        <property type="entry name" value="PsuG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42909">
        <property type="entry name" value="PTHR42909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04227">
        <property type="entry name" value="Indigoidine_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110581">
        <property type="entry name" value="SSF110581"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 6" id="KW-0464">Manganese</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="136"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="21"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH81797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="299" mass="30932" checksum="DBE2A6D519DB9E04" modified="2015-07-22" version="1">MHLTDEVRAALADRRPVVALESTIIAHGLPRPRNLQVAAELEDIVRSAGAVPATIAVLDGTPHVGLGGAQLERIASDDTVRKLTVRDLAPAAALGASGATTVAATAFLAARTGIGVFATGGLGGVHREWTQSQDESADLRLLAETRIAVVCAGVKSILDVPATLQRLETLGVTVLGYGTAEFPGFYLRTSGEPVEWTVRTPAEVAAVLRAQRELDVPPSAVIVANPVPAAEQLDPAVHDAVLADALREAERRGVSGQAITPFLLGYLTEHTRGASLEANLAAVRGNVRLAAEIAVAGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4Q5</accession>
    <name>A0A0F7N4Q5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 2">Adenylyl-sulfate kinase</fullName>
            <ecNumber evidence="1 2">2.7.1.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">APS kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">ATP adenosine-5'-phosphosulfate 3'-phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Adenosine-5'-phosphosulfate kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">cysC</name>
        <name evidence="3" type="ORF">AA958_05985</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 2">Catalyzes the synthesis of activated sulfate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 2">
            <text>adenosine 5'-phosphosulfate + ATP = 3'-phosphoadenylyl sulfate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24152"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 2">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the APS kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.25" evidence="1 2"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015180.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_05985"/>
    <dbReference type="EnsemblBacteria" id="AKH81827">
        <property type="protein sequence ID" value="AKH81827"/>
        <property type="gene ID" value="AA958_05985"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_05985"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1251"/>
    <dbReference type="OrthoDB" id="1574819at2"/>
    <dbReference type="UniPathway" id="UPA00140">
        <property type="reaction ID" value="UER00205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004020">
        <property type="term" value="F:adenylylsulfate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070814">
        <property type="term" value="P:hydrogen sulfide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02027">
        <property type="entry name" value="APSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00065">
        <property type="entry name" value="Adenylyl_sulf_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002891">
        <property type="entry name" value="APS_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00455">
        <property type="entry name" value="apsK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 2 3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="22"/>
            <end position="29"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH81827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="189" mass="20270" checksum="C7989509EABBE2E3" modified="2015-07-22" version="1">MPDNAPGADGVHARGATIWLTGLPSAGKTTLARTFGERLRDAGHRVEVLDGDEIREFLTAGLGFSREDRDTNVQRIGFVAELLASHGVKVLVPVIAPYADSREAVRKRHQTEGTTYVEVHVATPVDVCAERDVKGLYAKQAAGEISGLTGVDDPYEPPADPDLRIPTHEQSVEQSAAMLHAALVERGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4T2</accession>
    <name>A0A0F7N4T2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LuxR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_09225</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015725.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH82379">
        <property type="protein sequence ID" value="AKH82379"/>
        <property type="gene ID" value="AA958_09225"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_09225"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1946"/>
    <dbReference type="OrthoDB" id="1687028at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="7"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="158"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH82379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="234" mass="24535" checksum="3F4DB743E4C847DD" modified="2015-07-22" version="1">MTAQPIRVLLADDQTLVRKAFAMLVDSAADMEVVGEAGNGREAVALTRSERVDLVVMDLRMPELDGIEATRLIAADEDLAGVRVLVLTTYDTDEHIMAALRAGASGFLVKDTQPAALLEAIRTVAAGDALLSPGPTARLIERLVRLPEAPQPAATQHGGAALGALSERERQVLVLVARGLNNTEIAESLALSPLTAKTHVSRIMGKVGARDRAQLVVIGYESGLITPGSSSSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4U1</accession>
    <name>A0A0F7N4U1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_09280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015735.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH82389">
        <property type="protein sequence ID" value="AKH82389"/>
        <property type="gene ID" value="AA958_09280"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_09280"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1958"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="92" mass="9383" checksum="B4DE92B8A419B77D" modified="2015-07-22" version="1">MPIDLSRALEAYVRAQTLPPPPADKPADQPPAPEPREGRPAGHGPALEPDAAPEPDAAPDPTDHPAPAEPQADAVRPAPDVPPEPPGAPLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N542</accession>
    <name>A0A0F7N542_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA integrity scanning protein DisA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cyclic di-AMP synthase</fullName>
            <shortName evidence="10">c-di-AMP synthase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Diadenylate cyclase</fullName>
            <ecNumber evidence="10">2.7.7.85</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">disA</name>
        <name evidence="12" type="ORF">AA958_17870</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation; upon encountering a lesion, the DisA focus arrests at the damaged site and halts c-di-AMP synthesis.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Participates in a DNA-damage check-point that is active prior to asymmetric division when DNA is damaged. DisA forms globular foci that rapidly scan along the chromosomes during sporulation, searching for lesions. When a lesion is present, DisA pauses at the lesion site. This triggers a cellular response that culminates in a temporary block in sporulation initiation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>2 ATP = 3',3'-c-di-AMP + 2 diphosphate</text>
            <dbReference type="Rhea" id="RHEA:35655"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:71500"/>
            <dbReference type="EC" id="2.7.7.85"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homooctamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DisA family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.85" evidence="10"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017067.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_17870"/>
    <dbReference type="EnsemblBacteria" id="AKH83765">
        <property type="protein sequence ID" value="AKH83765"/>
        <property type="gene ID" value="AA958_17870"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_17870"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3764"/>
    <dbReference type="OrthoDB" id="1139866at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106408">
        <property type="term" value="F:diadenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019932">
        <property type="term" value="P:second-messenger-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01438">
        <property type="entry name" value="DisA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041663">
        <property type="entry name" value="DisA/LigA_HHH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038331">
        <property type="entry name" value="DisA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036888">
        <property type="entry name" value="DNA_integrity_DisA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018906">
        <property type="entry name" value="DNA_integrity_scan_DisA_link"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003390">
        <property type="entry name" value="DNA_integrity_scan_DisA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023763">
        <property type="entry name" value="DNA_integrity_scanning_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02457">
        <property type="entry name" value="DAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10635">
        <property type="entry name" value="DisA-linker"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12826">
        <property type="entry name" value="HHH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143597">
        <property type="entry name" value="SSF143597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51794">
        <property type="entry name" value="DAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAC" evidence="11">
        <location>
            <begin position="20"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="118"/>
            <end position="122"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AKH83765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="374" mass="40222" checksum="0EDC636B43EE48E4" modified="2015-07-22" version="1">MAAGDRAGAPGRAGGSSGSDAAVRAALSAVAPGTALRDGLERVLRGNTGGLIVLGTDKIIESICTGGFVLDVEFTATRLRELCKLDGAVVLDQDITRIERAGVQLLPDASIPTEETGTRHRTAQRVSIQSGFPVVSVSQSMRLIALYVDGQRRVLEDSAAILSRANQALATLERYKLRLDEVAGTLSALEIEDLVTVRDVSAVAQRLEMVRRIATEIAEYVVELGTDGRLLSLQLDELIAGVEPERQLVVRDYVPERTGRRPHTVDRALTELDRLSHGELLELPIVARSLGYSGVPETLDAAVSPRGYRLLAKVPRIPSAVIDRLVEHFGGLQKLLAASVDDLQTVDGVGEARARSVREGLSRLAESSILERYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N591</accession>
    <name>A0A0F7N591_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_06870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015334.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_06870"/>
    <dbReference type="EnsemblBacteria" id="AKH81982">
        <property type="protein sequence ID" value="AKH81982"/>
        <property type="gene ID" value="AA958_06870"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_06870"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1436"/>
    <dbReference type="OrthoDB" id="1604782at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="1">
        <location>
            <begin position="30"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="329" mass="35691" checksum="5EC8FFAE2157EAD2" modified="2015-07-22" version="1">MHIAVSGSIATDHLMTFPGRFSDQLVADQLHTVSLSFLVDKLDVRRGGVGPNICFGMGQLGARPILVGAAGADFGEYRDWLDRHGVDTGSVRISEVLHTARFVVTTDADHNQIGSFYTGAMSEARLIELKTVADRVGGLDLVSIGADDPEAMLRHTEECRTRGIPFAADFSQQIARMEGDGIRTLTEGAAFLFSNEYEKGLIETKTGWGDEEMLTHVATRVTTLGARGVRIDRAGEEPILVGCPEEERKADPTGVGDAFRAGFLSGLSWGVSMERAAQLGCMLATLVIETVGPQEYELRRSNFVARFTKVYGEEAAAEVQEHLPESVQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5J2</accession>
    <name>A0A0F7N5J2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">zf-HC2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_10970</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016001.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_10970"/>
    <dbReference type="EnsemblBacteria" id="AKH82663">
        <property type="protein sequence ID" value="AKH82663"/>
        <property type="gene ID" value="AA958_10970"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_10970"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2309"/>
    <dbReference type="OrthoDB" id="1740922at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041916">
        <property type="entry name" value="Anti_sigma_zinc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027383">
        <property type="entry name" value="Znf_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13490">
        <property type="entry name" value="zf-HC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="zf-HC2" evidence="3">
        <location>
            <begin position="11"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH82663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="239" mass="24848" checksum="0584DAE4B6132C78" modified="2015-07-22" version="1">MTGKRHPDVGAYAIGALEHDEAERFEEHLAGCERCAAALAELVPVADMLADVPPPQDPPPGALDRLLAELTAVRARQRRVRRRLVVAVTAAAVVAVAAPVVTAVVLTGEEPAPEQRRADVAGQEVRAVDPETGVEARISMRPVTWGTSVDLDLRGVSGPRRCDLQAVGRDGSHETVTSWGVPADGYGAGDGRNAGASGRGGGTSLRTSGGTSMSPDDIDHFEVVTSEGDRLVIVPAEAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5J7</accession>
    <name>A0A0F7N5J7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphoribosylformylglycinamidine synthase subunit PurS</fullName>
            <shortName evidence="5">FGAM synthase</shortName>
            <ecNumber evidence="5">6.3.5.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Formylglycinamide ribonucleotide amidotransferase subunit III</fullName>
            <shortName evidence="5">FGAR amidotransferase III</shortName>
            <shortName evidence="5">FGAR-AT III</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Phosphoribosylformylglycinamidine synthase subunit III</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">purS</name>
        <name evidence="6" type="ORF">AA958_18360</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + H2O + L-glutamine + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide = 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ADP + H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17129"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PurS family.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.3" evidence="5"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017143.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_18360"/>
    <dbReference type="EnsemblBacteria" id="AKH83845">
        <property type="protein sequence ID" value="AKH83845"/>
        <property type="gene ID" value="AA958_18360"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_18360"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3855"/>
    <dbReference type="OrthoDB" id="2012814at2"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00128"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004642">
        <property type="term" value="F:phosphoribosylformylglycinamidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01926">
        <property type="entry name" value="PurS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003850">
        <property type="entry name" value="PurS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036604">
        <property type="entry name" value="PurS-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34696">
        <property type="entry name" value="PTHR34696"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02700">
        <property type="entry name" value="PurS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82697">
        <property type="entry name" value="SSF82697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00302">
        <property type="entry name" value="TIGR00302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 5" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH83845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="89" mass="9660" checksum="B57F37D6FCC0A9D8" modified="2015-07-22" version="1">MARVVVDVMLKPEILDPQGQAVQRALPRLGFAGIADVRQGKRFELEVEGPVDDAALAQINTMAETFLANTVIEDFTVRVEEVAHGGEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5U0</accession>
    <name>A0A0F7N5U0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acetyl-CoA acetyltransferase</fullName>
            <ecNumber evidence="6">2.3.1.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_11595</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.9" evidence="6"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_11595"/>
    <dbReference type="EnsemblBacteria" id="AKH82769">
        <property type="protein sequence ID" value="AKH82769"/>
        <property type="gene ID" value="AA958_11595"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_11595"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2439"/>
    <dbReference type="OrthoDB" id="330994at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003985">
        <property type="term" value="F:acetyl-CoA C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="4">
        <location>
            <begin position="6"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="5">
        <location>
            <begin position="287"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="2">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="366"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH82769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="411" mass="42917" checksum="61BF911FD70127D3" modified="2015-07-22" version="1">MMPEAVIVSAARSPIGRAGKGSLKDVRPDDLTAGIVRAALDKVPGLDPGDIDDLMLGCGLPGGEQGHNLGRVVAVQLGMDHLPGCTVTRYCSSSLQTTRMAFHAIKAGEGDVFVSAGVETVSRFVNGSSDGMPGTHNPFFAEAEARTAERQEKGSAFEGGGWHDPRADGLVPDVYIAMGQTAENLARAKGVTRQDMDEFGVRSQNLAEKAIAAGFWEREITPVTTPDGTVVTKDDGPRPGVTMEGVAGLKPVFRPDGRVTAGNCCPLNDGAAAVVVMSDTKARELGLTPLARIVSTGLSALSPEIMGLGPVEASRQALARAGMAIGDIDLVEINEAFAAQVIPSYRDLGIDLDRLNVNGGAIAVGHPFGMTGARITTTLINSLQWHDKQFGLETMCVGGGQGMAMVLERLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N608</accession>
    <name>A0A0F7N608_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Branched-chain amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_08440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018834472.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_08440"/>
    <dbReference type="EnsemblBacteria" id="AKH82257">
        <property type="protein sequence ID" value="AKH82257"/>
        <property type="gene ID" value="AA958_08440"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_08440"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1782"/>
    <dbReference type="OrthoDB" id="1965661at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008407">
        <property type="entry name" value="Brnchd-chn_aa_trnsp_AzlD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05437">
        <property type="entry name" value="AzlD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="106" mass="10867" checksum="F75B15C8C1108136" modified="2015-07-22" version="1">MSTTTLVFAVFVLGAGTFAFRFAGPALRSRVRLEPRVERLMTVAAIVLLTALVGTQALLDDGGFAGVARPAGVAVGGVLAWRRAPFVVVVVAAAATAALLRLCGVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N664</accession>
    <name>A0A0F7N664_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glyoxalase_6 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_20045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017385.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_20045"/>
    <dbReference type="EnsemblBacteria" id="AKH84095">
        <property type="protein sequence ID" value="AKH84095"/>
        <property type="gene ID" value="AA958_20045"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_20045"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4223"/>
    <dbReference type="OrthoDB" id="1984437at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041581">
        <property type="entry name" value="Glyoxalase_6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18029">
        <property type="entry name" value="Glyoxalase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyoxalase_6" evidence="1">
        <location>
            <begin position="8"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="121" mass="13441" checksum="23537E177F1FECAB" modified="2015-07-22" version="1">MDAYVRNIVLDCADARQLADFYTQLLGMRVIREDWMVIAKDEDSFPRLAFEEVEGYRPPLWPDLDRTYPQQMHICFGVDDSTAAGELALRLGATRLSEAGGSCPVFADPAGHPFCLCGPGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6D8</accession>
    <name>A0A0F7N6D8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NADH-quinone oxidoreductase subunit A</fullName>
            <ecNumber evidence="6">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">NADH dehydrogenase I subunit A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">NDH-1 subunit A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">NUO1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">nuoA</name>
        <name evidence="8" type="ORF">AA958_20580</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6 7">Cell membrane</location>
            <topology evidence="6 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the complex I subunit 3 family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018840719.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_20580"/>
    <dbReference type="EnsemblBacteria" id="AKH84185">
        <property type="protein sequence ID" value="AKH84185"/>
        <property type="gene ID" value="AA958_20580"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_20580"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4342"/>
    <dbReference type="OrthoDB" id="1748431at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01394">
        <property type="entry name" value="NDH1_NuoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023043">
        <property type="entry name" value="NAD(P)H_OxRDtase_bac/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000440">
        <property type="entry name" value="NADH_UbQ/plastoQ_OxRdtase_su3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038430">
        <property type="entry name" value="NDAH_ubi_oxred_su3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11058">
        <property type="entry name" value="PTHR11058"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00507">
        <property type="entry name" value="Oxidored_q4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 7" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6 7" id="KW-0874">Quinone</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH84185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="119" mass="13252" checksum="714210F441343B8C" modified="2015-07-22" version="1">MNVYTPILVLGAIAAAFAVFSVVAAALVGPKRYNRAKLEAYECGIEPTPMPPGGGRFPVKYYLTAMLFIIFDIEIVFLYPWAVSFDALGIFGLVEMLLFVLTVFVAYAYVWRRGGLEWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6Q5</accession>
    <name>A0A0F7N6Q5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">50S ribosomal protein L17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rplQ</name>
        <name evidence="7" type="ORF">AA958_21320</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Part of the 50S ribosomal subunit. Contacts protein L32.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the bacterial ribosomal protein bL17 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017579.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_21320"/>
    <dbReference type="EnsemblBacteria" id="AKH84315">
        <property type="protein sequence ID" value="AKH84315"/>
        <property type="gene ID" value="AA958_21320"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_21320"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4489"/>
    <dbReference type="OrthoDB" id="1838961at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1030.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01368">
        <property type="entry name" value="Ribosomal_L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000456">
        <property type="entry name" value="Ribosomal_L17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036373">
        <property type="entry name" value="Ribosomal_L17_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14413">
        <property type="entry name" value="PTHR14413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01196">
        <property type="entry name" value="Ribosomal_L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64263">
        <property type="entry name" value="SSF64263"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00059">
        <property type="entry name" value="L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01167">
        <property type="entry name" value="RIBOSOMAL_L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="131"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH84315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="191" mass="20207" checksum="C32136E0A407E8AB" modified="2015-07-22" version="1">MPKPTKGARLGGGAAHERAMLRNLATALFEHGRITTTEAKARRLRPYAERLVTKAKKGDLHNRRQVMQLISDKSVVHTLFTEIGPRYDNRPGGYTRITKIGNRRGDNAKMAVIELVEALTVQQEAVGEAEAATKRSAKDVAGEEAAAGLKKDTEAAGAADATEAGAAESEAAESEAGEAAESAEGKDAKNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6S3</accession>
    <name>A0A0F7N6S3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_17900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017073.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH83771">
        <property type="protein sequence ID" value="AKH83771"/>
        <property type="gene ID" value="AA958_17900"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_17900"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3770"/>
    <dbReference type="OrthoDB" id="1772343at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="2">
        <location>
            <begin position="16"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH83771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="134" mass="14509" checksum="3566659E60BFE874" modified="2015-07-22" version="1">MARTPAPAPSGDELLKVLAALGNPHRLRIVAALHQGRNYVSRLAREIGMSRPLLHMHLQRLEAAGLITGSLELSADGKAMKFYEVVSFRYELTPELIAEVARTLGDGDGEPEGEPPGKDKARTGKPETVKEEAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6Y9</accession>
    <name>A0A0F7N6Y9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HAD family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_10620</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAD-like hydrolase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015943.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_10620"/>
    <dbReference type="EnsemblBacteria" id="AKH82602">
        <property type="protein sequence ID" value="AKH82602"/>
        <property type="gene ID" value="AA958_10620"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_10620"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2234"/>
    <dbReference type="OrthoDB" id="1308416at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000915">
        <property type="entry name" value="PGP-type_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01460">
        <property type="entry name" value="HAD-SF-IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="13"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR000915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000915-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH82602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="259" mass="27987" checksum="95769D8FC54ADB13" modified="2015-07-22" version="1">MAERMPVESWLTDMDGVLMHEGIPIPGADAFIKRLRDSGKPFLVLTNNSIYTPGDLHARLSRIGLDVPVQNIWTSALATAKFLDDQRPGGTAYVIGEAGLTTALHDHGYVLSDHRPDYVVLGETRTYSFEALTKAIRLIENGARFIATNPDQTGPSTEGPLPATGAVAALITKATGKEPYFVGKPNPLMMRAGLNQIGAHSESTAMIGDRMDTDVLAGLEAGMETYLVLTGLTRADQVERFPYRPSHIVDSIADLVTLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N775</accession>
    <name>A0A0F7N775_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glutamyl-tRNA amidotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_14510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016559.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_14510"/>
    <dbReference type="EnsemblBacteria" id="AKH83244">
        <property type="protein sequence ID" value="AKH83244"/>
        <property type="gene ID" value="AA958_14510"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_14510"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3055"/>
    <dbReference type="OrthoDB" id="1498741at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016884">
        <property type="term" value="F:carbon-nitrogen ligase activity, with glutamine as amido-N-donor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003789">
        <property type="entry name" value="Asn/Gln_tRNA_amidoTrase-B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023168">
        <property type="entry name" value="GatB_Yqey_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019004">
        <property type="entry name" value="YqeY/Aim41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042184">
        <property type="entry name" value="YqeY/Aim41_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28055">
        <property type="entry name" value="PTHR28055"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09424">
        <property type="entry name" value="YqeY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89095">
        <property type="entry name" value="SSF89095"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH83244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="155" mass="16326" checksum="599D61373678F944" modified="2015-07-22" version="1">MTTLKSKLQDDLTAAIKGRDELRAATLRMTLTAITKEEVAGKEARVLSDDEVLKVITREAKKRREAAEAFAQGGRTESAERERAEGEVLADYLPKQLGDEELAALVGEAVAEAKAGGAEGPRAMGAVMKIVNPKVAGRAEGGRVAAAVKRALGQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7A4</accession>
    <name>A0A0F7N7A4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Cell division ATP-binding protein FtsE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ftsE</name>
        <name evidence="8" type="ORF">AA958_11155</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Part of the ABC transporter FtsEX involved in cellular division.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer. Forms a membrane-associated complex with FtsX.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016035.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_11155"/>
    <dbReference type="EnsemblBacteria" id="AKH82697">
        <property type="protein sequence ID" value="AKH82697"/>
        <property type="gene ID" value="AA958_11155"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_11155"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2350"/>
    <dbReference type="OrthoDB" id="1181903at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005286">
        <property type="entry name" value="Cell_div_FtsE_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02673">
        <property type="entry name" value="FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="2"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH82697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="229" mass="25839" checksum="6116DFFB06D841D2" modified="2015-07-22" version="1">MIRFDNVTKMYPKQNRPALQDVSLEIERGEFVFLVGSSGSGKSTFLRLILREERTTHGQVYVLGKDLARLSNWKVPQMRRQLGTVFQDFRLLPNKTVAENVAFALEVIGKPRGQIRKTVPEVLDLVGLSGKGDRMPGELSGGEQQRVAVARAFVNRPMLLIADEPTGNLDPQTSVGIMKLLDRINRTGTTVIMATHDQQIVDQMRRRVIELELGRLVRDQSRGVYGYQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7F6</accession>
    <name>A0A0F7N7F6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_19160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017251.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH83956">
        <property type="protein sequence ID" value="AKH83956"/>
        <property type="gene ID" value="AA958_19160"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_19160"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4028"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="148" mass="15237" checksum="AB79280DAB82AF92" modified="2015-07-22" version="1">MAERRVRAESCCAAGETETGFGERVALGGRRRLLVRRVLLSASLAFAVAAVVVTITGGSPGLADRLAWATCVWGAGLALGLVRRVVTGRSLDWRLVVIVAGVVVGAAWQPLAAAVVAVALLAEQVLRRRGARAPAAGQVPSQFVGQAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7R6</accession>
    <name>A0A0F7N7R6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GCN5 family acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_15860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016751.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_15860"/>
    <dbReference type="EnsemblBacteria" id="AKH83439">
        <property type="protein sequence ID" value="AKH83439"/>
        <property type="gene ID" value="AA958_15860"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_15860"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3341"/>
    <dbReference type="OrthoDB" id="1563557at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="124"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="252" mass="25824" checksum="2842387D215E506C" modified="2015-07-22" version="1">MDKQVQNFAVANLRRRPDVVETGGFVAGFAADTDSPYLNYATPLPGTAPTPADVAALVGAFRERGLLPRLEFAPQAAPLVAGALRAAGFATEAVHEYLVCTPHTYTAPLPGGSHPRVETPTTDAEFRALDAALAEAFGGAFAASAEGAARLRRLGEDGGEVRFVRAGDGGCAGGATCSPPAEDTAELAGVGTRPAHRRRGVAAAVTAALTAAIFERGAGSVWLESSGAGSRGTYTRVGYRPGGTRLYVSLPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7V4</accession>
    <name>A0A0F7N7V4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NUDIX hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_23505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017935.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_23505"/>
    <dbReference type="EnsemblBacteria" id="AKH84680">
        <property type="protein sequence ID" value="AKH84680"/>
        <property type="gene ID" value="AA958_23505"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_23505"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4956"/>
    <dbReference type="OrthoDB" id="1308416at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="45"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="176" mass="19195" checksum="F10A6CA10B933E8C" modified="2015-07-22" version="1">MTLRDDAERVLKEWSAPDGDQDALRLRYLEFLAAHPDGMWKPCADGHMTASALIVDTAHERVLLTLHRKLNMWLQTGGHCEPEDATLAAAALREAHEESGVAGLTLLPGGPVGLDLHHTPCAWHLDVQYVALAPEGAVPAISEESLDLRWYGYDAVAGVADESVALLMERTRARLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N848</accession>
    <name>A0A0F7N848_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MucB_RseB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_20660</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017487.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_20660"/>
    <dbReference type="EnsemblBacteria" id="AKH84201">
        <property type="protein sequence ID" value="AKH84201"/>
        <property type="gene ID" value="AA958_20660"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_20660"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4358"/>
    <dbReference type="OrthoDB" id="1525859at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16325">
        <property type="entry name" value="LolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029046">
        <property type="entry name" value="LolA/LolB/LppX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033434">
        <property type="entry name" value="MucB/RseB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004564">
        <property type="entry name" value="OM_lipoprot_carrier_LolA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03888">
        <property type="entry name" value="MucB_RseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89392">
        <property type="entry name" value="SSF89392"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="MucB_RseB" evidence="3">
        <location>
            <begin position="119"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH84201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="406" mass="41009" checksum="B5C498E7ACAE242E" modified="2015-07-22" version="1">MALIPPERPADEAEDRAADLAAARRRKAVRYGVPLGIAGLAAATIGLVPALAQDEGPSKDDVTAGELIAKALASEVESVDGTVKVSTDLGLPSIPFGGGGGGGEGADLSRLLAGDTKLHVAADGPEKQRVTLTGSDGDRTVVRNGTDVWTFGGGSDEVSHSTLPKDAGKKDGKEHGLGLPEDLKDATPQELAERLLKAADETTDVDVAGTAQVAGQDAYELRLTPKQDESTVRDVTIAVDADNGVPLRVALTADDGNTVLDAGFTKVDFNKPDAGLFAPPAGADVTEKGSGEGFGEGHGGDFGKGFGGFGGAWSGGDWSGGDRAGGGTPGGLEDVKVHGEGWGSIAEISLPGGTLSEDGAGAALDFFTDKTDAGRVFESRLVNVLITDDKVYVGAVTPEALEAAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N862</accession>
    <name>A0A0F7N862_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_12825</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AfsR/DnrI/RedD regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_12825"/>
    <dbReference type="EnsemblBacteria" id="AKH82962">
        <property type="protein sequence ID" value="AKH82962"/>
        <property type="gene ID" value="AA958_12825"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_12825"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2696"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15831">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03704">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="11"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="11"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH82962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="967" mass="103318" checksum="D416B2F3F63DF48E" modified="2015-07-22" version="1">MYRRGWGTAEGRAVARGAVVYFAVLGPVAAWRGAAPVNVGPPQQRTVLAALLIGSGHHATTHELVDALGGEDPPRDAVGTVRTHVSRLRKALGPDADLITGQAGGYVLRPGAGAVPDVAIAEEAVALADAAAHDGDAGRARSLLREALGLWDGGPLAGLPGTFAETERARLTEWRLSLLERRLALGIESHDYAEAISELTALTAAYPLRERFRELLMLSLSRSGRQAEALAVSTDSRRLSIDELGVEPGPKLAELQQRILRGGEQPVAPAATTTARLSPAQLPARLADFTGRDAFVDELGKQLEQASGMVMAVSSVSGIGGVGKTTLAVHVGHAVRDSFPDGQLYADLQGAGASPAEPAAVLGSFLRSLGTPDAEIPEPLEERAALFRSTLAGRRVLTLLDNARDAAQVRPLLPGTEGCAAVITSRARMTDLASAHHVDLDVMAPDEALLLFTRIVGAHRVTPERNAAMDVVAACGFLPLAIRIAASRLAARRTWTVSVLARKLSDEHRRLDELRVGDLAVKATFELGYGQLEPEQARAFRLLGLADGPDISLSAAAAILDRTEDDAEDLLETLVDTSLLESAAPGRYRYHDLLRLFARACAHREEPEAERDAAQSRLLDHYLAAAARVYELGRPGDTLVKHLSPVVHAGPCFDDRQAAQDWLFSEAECLLAAVRQFAHGDSLPRTVGLLLATKDLAESGLYSPRFVPLATAVIQAAEQRGDIRSQARAHVVLSSAHQFTGRFELSYEHAGHACRLAGACNDIWTAGEAANDRGVTASLLGNLDDARYYLDQALVAYRADGNLNGESYALGNLARVHLDAGATATAIEMAQQTVEIDRQAGALLRMACSRYHLAIALNQANRHLGALTQLDLAVATFREDRMGLWEGLAHFRIAQVHLSMRQPAEAASYAEKALSRFRGIGGDWHRGSVLTVLGRALGELGQRDRAQACLSEARELRESGSTQAQQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N884</accession>
    <name>A0A0F7N884_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Diguanylate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_17040</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016938.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_17040"/>
    <dbReference type="EnsemblBacteria" id="AKH83634">
        <property type="protein sequence ID" value="AKH83634"/>
        <property type="gene ID" value="AA958_17040"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_17040"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3583"/>
    <dbReference type="OrthoDB" id="1734230at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="96"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="141"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="92"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH83634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="297" mass="31148" checksum="09B6A1F42EC1DB33" modified="2015-07-22" version="1">MPTVELTTAPPPPTAATPPRRGGRHLLRSLAANRRTSIAGGFLLLVFAAALLAPVIAPHDYRDIAGTPLTQGGMLGIDDYGRDVFSRLLIGLRTSLAVALSAVLIAGAIGTTLGLVAGYGGRWASSIIMRGIDILLSFPPIVLAIAVVAAMGPELVNVVMVIGVLYIPRFTRIVYSQVLAIRSVEYVEAAEIMGTGRSTILLRTILPNVAAPVIVQLSLSVSFAIQMEAGLSFLGLGAQPPLPSLGTMVGAGRDFLEVQPTLLIYPSVLIILIVLALNVFGDGLRDLLDPRRSGTDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N942</accession>
    <name>A0A0F7N942_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">4-hydroxy-3-methylbut-2-enyl diphosphate reductase</fullName>
            <shortName evidence="6">HMBPP reductase</shortName>
            <ecNumber evidence="6">1.17.7.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ispH</name>
        <name evidence="7" type="ORF">AA958_22700</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>H2O + isopentenyl diphosphate + 2 oxidized [2Fe-2S]-[ferredoxin] = (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:24488"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:128753"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="EC" id="1.17.7.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>dimethylallyl diphosphate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] = (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:24825"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:128753"/>
            <dbReference type="EC" id="1.17.7.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from (2E)-4-hydroxy-3-methylbutenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 6/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the IspH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.17.7.4" evidence="6"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_22700"/>
    <dbReference type="EnsemblBacteria" id="AKH84546">
        <property type="protein sequence ID" value="AKH84546"/>
        <property type="gene ID" value="AA958_22700"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_22700"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4775"/>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00097"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00059">
        <property type="reaction ID" value="UER00105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051745">
        <property type="term" value="F:4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050992">
        <property type="term" value="P:dimethylallyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13944">
        <property type="entry name" value="lytB_ispH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00191">
        <property type="entry name" value="IspH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003451">
        <property type="entry name" value="LytB/IspH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30426">
        <property type="entry name" value="PTHR30426"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02401">
        <property type="entry name" value="LYTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00216">
        <property type="entry name" value="ispH_lytB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="204"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH84546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="305" mass="32905" checksum="5B4E3A2C34C09099" modified="2015-07-22" version="1">MIAVEQALEQYGAPVYVRHEIVHNKYVVKTLERKGAIFVEETAEVPPGNIVIFSAHGVAPTVHDEAKEGRLATIDATCPLVTKVHKEAVRFAKDDFDILLIGHEGHEEVIGTSGEAPEHIQLVDGPEGADQIEVRDPDKVVWLSQTTLSVDETMETVDRLKGRFPNLLDPPSDDICYATQNRQVAVKQVGAESDLVIVVGSQNSSNSLRLVEVAVDAGAKASYLVDGAEEIDEAWLDGVTTVGVTSGASVPEVLVDGVLEWLAERGYVDVDLVQPVDERITFSLPKELRRDLRAEAAALGGGAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9H0</accession>
    <name>A0A0F7N9H0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_15250</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M28 family. M28A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016661.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_15250"/>
    <dbReference type="EnsemblBacteria" id="AKH83347">
        <property type="protein sequence ID" value="AKH83347"/>
        <property type="gene ID" value="AA958_15250"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_15250"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3212"/>
    <dbReference type="OrthoDB" id="1465483at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03876">
        <property type="entry name" value="M28_SGAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029514">
        <property type="entry name" value="Ape3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041756">
        <property type="entry name" value="M28_SGAP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="PTHR12147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147:SF17">
        <property type="entry name" value="PTHR12147:SF17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519206" evidence="5">
        <location>
            <begin position="30"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="PA" evidence="6">
        <location>
            <begin position="141"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M28" evidence="7">
        <location>
            <begin position="255"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="489"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH83347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="510" mass="53330" checksum="DC27DA8C5B2BC067" modified="2015-07-22" version="1">MFPRRFTAALGAAALAVPLLLASSAPAGAAQPAKDGAKLARDLVRASSAADAYKHLKAFQRIADRNGGHRAAGSPGYEASAAYVYDQLKQAGYDVGYDTFDFTYSETLKDEFAVVSPEARDIEIFAMTFSKSTPEGGLDAPLAAVPVDADGTSGCEPGDFTGGDYTGKVALVQRGGCNFSVKQAHAADAGAVATVIYNNTEGALNGTLGDADAVKVPTGGITKAEGEALTTLLTQGEVTVHVDIQTIVEPRTTRNVIAETRGGAEDRTVMLGAHLDSVAEGAGINDNASGSAALLEVAKELAKAEKKPRNQVRFAFWSAEELSLVGSTDYVSRLTPRQLRDIELYLNFDMVASPNYGLFVYDGDDSDGVGEGPGPEGSAQLERQITDFMDRKGMPHEGTDFTGRSDYGPFIEVGIPSGGTFTGAEGTKTEAQAVKFGGTAGKAYDPCYHTACDDLDNISMPAFDANIDVIAHAVGTYAHDVSSLREPVSFVPTEGDEGSGGGAHDDHAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9K7</accession>
    <name>A0A0F7N9K7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_23740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_037740986.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_23740"/>
    <dbReference type="EnsemblBacteria" id="AKH84721">
        <property type="protein sequence ID" value="AKH84721"/>
        <property type="gene ID" value="AA958_23740"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_23740"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5003"/>
    <dbReference type="OrthoDB" id="1955945at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="78" mass="8444" checksum="1021C0F1A3434466" modified="2015-07-22" version="1">MAGFLDRAKEKAETALNQGKEKVGEVQAQREGQALLRRLGAAYFNEQRGSGSPQEVQDALQAVHAHIAQHGDGFLTRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9W5</accession>
    <name>A0A0F7N9W5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Adenine deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_21000</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017544.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_21000"/>
    <dbReference type="EnsemblBacteria" id="AKH84259">
        <property type="protein sequence ID" value="AKH84259"/>
        <property type="gene ID" value="AA958_21000"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_21000"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4424"/>
    <dbReference type="OrthoDB" id="554648at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019239">
        <property type="term" value="F:deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009168">
        <property type="term" value="P:purine ribonucleoside monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006650">
        <property type="entry name" value="A/AMP_deam_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001365">
        <property type="entry name" value="A_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006330">
        <property type="entry name" value="Ado/ade_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43114">
        <property type="entry name" value="PTHR43114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00962">
        <property type="entry name" value="A_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01430">
        <property type="entry name" value="aden_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00485">
        <property type="entry name" value="A_DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="A_deaminase" evidence="4">
        <location>
            <begin position="16"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="346"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH84259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="384" mass="41110" checksum="8D907B7B12AB455B" modified="2015-07-22" version="1">MEHDHRAAARDVRRLPKAHLHLHFTGSMRSATLIELAGKYGVHLPEALSSGEPPKLRATDERGWFRFQRLYDLARSCLRTPEDIQRLVREAAEEDLADGSGWLEIQVDPTSYAPRLGGLIPALEIILDAVETTARETGLGMRVLVAANRMKHPLDARTLARLAVRYADRGVVGFGLSNDERRGFARDFDRAFAIARDGGLLAAPHGGELAGPPSVRDCLDDLDARRIGHGIRAAEDPRLLSRLAAAGVTCEVCPSSNVALGVYERPQDVPLRALWDAGVPMALGADDPLLFGSRLAAQYELARTHHGFTDEELAELARQSVRASVAPEDVRRGLLARVDDWLSGEPEAGRQAAGGAAGGAAAADGGASAAQSVRDRAAAKSSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9X7</accession>
    <name>A0A0F7N9X7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 8">Phosphoglucosamine mutase</fullName>
            <ecNumber evidence="6 8">5.4.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">glmM</name>
        <name evidence="13" type="ORF">AA958_21360</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 8">Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 8">
            <text>alpha-D-glucosamine 1-phosphate = D-glucosamine 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23424"/>
            <dbReference type="ChEBI" id="CHEBI:58516"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="EC" id="5.4.2.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="PTM">
        <text evidence="6">Activated by phosphorylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.10" evidence="6 8"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017586.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_21360"/>
    <dbReference type="EnsemblBacteria" id="AKH84323">
        <property type="protein sequence ID" value="AKH84323"/>
        <property type="gene ID" value="AA958_21360"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_21360"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4497"/>
    <dbReference type="OrthoDB" id="1265792at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008966">
        <property type="term" value="F:phosphoglucosamine mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05802">
        <property type="entry name" value="GlmM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01554_B">
        <property type="entry name" value="GlmM_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
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        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006352">
        <property type="entry name" value="GlmM_bact"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="SSF55957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01455">
        <property type="entry name" value="glmM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 6 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGM_PMM_I" evidence="10">
        <location>
            <begin position="3"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_II" evidence="11">
        <location>
            <begin position="166"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_III" evidence="12">
        <location>
            <begin position="265"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_IV" evidence="9">
        <location>
            <begin position="381"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphoserine intermediate" evidence="6">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <feature type="binding site" description="via phosphate group" evidence="6">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="Phosphoserine" evidence="6">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AKH84323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="454" mass="47198" checksum="91A001F13D6DCFD6" modified="2015-07-22" version="1">MGRLFGTDGVRGVANADLTAEMALGLSVAAAHVLAIADAAQPAGQRPKAVVGRDPRASGEFLEAAVVAGLASAGVDVLRVGVLPTPAVAYLTGALGADLGVMLSASHNPMPDNGVKFIARGGHKLSDELEDEIEELYHKHERGEPWERPTGAGVGRVQRYEQGFDRYVAHLLGVLPHRLDGLKVVVDGAHGAAARVSPEAFQRAGAEVIPIGTEPTGLNINDGYGSTHLDQLSAAVVEHGADLGIAHDGDADRCLAVDAAGKEIDGDQILAVLALGLREAGRLRKNTVVATVMSNLGFKLALEREGVDLIQTAVGDRYVLEEMKRGGYALGGEQSGHVIVLDHATTGDGTLTGLLLASRVAASGRPLAELAAVMDRLPQVLINVRDVDKSRVASAPELRQAVLEAERELGATGRVLLRSSGTEPVVRVMVEAADIDQARSVAGKLADVVKSALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9Z5</accession>
    <name>A0A0F7N9Z5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">XRE family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_27460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85350.1"/>
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    <dbReference type="EnsemblBacteria" id="AKH85350">
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        <property type="gene ID" value="AA958_27460"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_27460"/>
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    <dbReference type="OrthoDB" id="1069752at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
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        <property type="entry name" value="Cupin_2"/>
    </dbReference>
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        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="14"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="211" mass="22049" checksum="9A5D168DE0D5A1CB" modified="2015-07-22" version="1">MVREQAGRVLGANLRALRARAGLSLSGLARASGIAKGTLSQLESGTGNPTIETVFSLSNALGVPVSSLLTEREDPDVLLVRSAGLDVLSSNAVDLRMLRRMDLTDTVVELYDQRVRPGEVQHSAGHPGREHVVVTSGRLRVGPPEAPYELGPGDYVCFPAAAPHVYETVGGPVLSVLMLEYPAAAHPVPPVASCAVPAPRQNAPRVPGTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9Z9</accession>
    <name>A0A0F7N9Z9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Universal stress protein UspA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_27495</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018589.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH85355">
        <property type="protein sequence ID" value="AKH85355"/>
        <property type="gene ID" value="AA958_27495"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_27495"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5793"/>
    <dbReference type="OrthoDB" id="2040681at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="6"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="151"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH85355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="294" mass="29905" checksum="8BDB76CFD6512E7E" modified="2015-07-22" version="1">METAPVVVGVDGSAAGLDAVAVAAREAKLRGCPLRVVHAFLWPAFGAYPGAPGMLPGDTALRKEAEKAVEDAVAHARSAEPRVTAHGAVVTGEAMEILVRETKTAQLAVVAGRGLSAFTRLLVGSTAVHLSAYGHCPVLVVRAGGAGPRGPVLLAVDGSPAGAAAVEFAFAEAARRRAGLVALHVWSAWTRYAPRRDEPARPTADGPAAEGDRVLAEALAGAEKSYPDVRVERTAVEGSARELLIEASKDAGLLVTGARGHGGFAGLLLGSVSQALLQHAHCPVAVVRGAGGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NA20</accession>
    <name>A0A0F7NA20_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_24720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018128.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_24720"/>
    <dbReference type="EnsemblBacteria" id="AKH84876">
        <property type="protein sequence ID" value="AKH84876"/>
        <property type="gene ID" value="AA958_24720"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_24720"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5213"/>
    <dbReference type="OrthoDB" id="1054546at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="15"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="327" mass="36880" checksum="1B6EBA0AE0E2129D" modified="2015-07-22" version="1">MQNRTMGRLGWQVSEIGYGMWGIGGGPGGFTGWDYDVAPDCLDLAVELGCTFFDTAWVYGRGVSEQLLAALLKRHPERRLYTATKVPPRNREWPPGKDDTLDDVFPPDHVREYVHRSLENLGTDSIDLLQFHVWEDRWAGDERWQRVVADLKAEGVIEGFGISVNRWEPENCMRALDTGLIDVVQVIYNIFDQAPEDELFERAQRDGIGIIARVPFDEGGLTGTLTRQTSFPEDDWRAVYFGPDNLGPTVDRAEALKKVLPEGMTLPELALRFILHHPAVSTVIPGMRKPAHVRANVAVSDAPPLDAGLLAELRRHRWDRRPTAWSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NA73</accession>
    <name>A0A0F7NA73_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_16910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016916.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_16910"/>
    <dbReference type="EnsemblBacteria" id="AKH83612">
        <property type="protein sequence ID" value="AKH83612"/>
        <property type="gene ID" value="AA958_16910"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_16910"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3558"/>
    <dbReference type="OrthoDB" id="1478362at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="21"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="276" mass="30444" checksum="D65CC19D378340CE" modified="2015-07-22" version="1">MPARPRELTPDRSARHLFGAKMRAHRMRAGMSLEALNDVVNISRSHLARIETAEAMPPPDLPPRLDAAFGTDGIFQELYRLAAKEIHPDQFKRRMELEARAQAIGEYGGQIVPGILQTEGYARAQFRQANPWASEDSIEELVTARMSRQSVLTSDTLMDYSAVLDEAALRRGFGGPEVMRTQLAHLAELTLTQKTMVQVVPFGLGGHALAGGTLTLMTSADGARVAYEESITTGTLMEEKESVVERQRVYDLLRASALSPDDSATFFRSVMEVLPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAC3</accession>
    <name>A0A0F7NAC3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Flavoprotein disulfide reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_22180</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="2">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017714.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_22180"/>
    <dbReference type="EnsemblBacteria" id="AKH84453">
        <property type="protein sequence ID" value="AKH84453"/>
        <property type="gene ID" value="AA958_22180"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_22180"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4671"/>
    <dbReference type="OrthoDB" id="267896at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="4">
        <location>
            <begin position="6"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_dim" evidence="3">
        <location>
            <begin position="364"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="199"/>
            <end position="206"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH84453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="483" mass="50329" checksum="6B1B99E84F2999F8" modified="2015-07-22" version="1">MGYVTRIVIIGGGPGGYEAALVAAQLGAEVTVVDSDGLGGASVLTDCVPSKTLIATAEVMTTFDSSYEELGIIVADDTPPEEQAARVVGVDLGKVNARVKRLALAQSEDITTSVTRAGGRVVRGRASVSPQQAPDGSRTVRVTGAAVGEPAELVADAVLVATGGSPRELPDAQPDGERILNWKQVYDLDELPAELIVVGSGVTGAEFAGAYQALGSRVTLVSSRDRVLPGEDPDAAAVLEDVFRRRGMNVMSRSRAQGAKRVGDRVEVTLNDGRVITGSHCLMAVGAVPNTRGIGLEEAGVRLTDSGHVWTDKVSRTSAPGIYAAGDCTGVFALASVAAMQGRIAMYHFLGETVAPLRLKTVSANVFTDPEIATVGYQQSDVDEGRIDARVMKLPLLRNPRAKMQGVRDGFVKLICRPGTGIVVGGVVVAPRASELIHPISIAVDNNLTVEQIAKAFTVYPSLSGSIAEVARQLQASKPGGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAI3</accession>
    <name>A0A0F7NAI3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">dCTP deaminase, dUMP-forming</fullName>
            <ecNumber evidence="3">3.5.4.30</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Bifunctional dCTP deaminase:dUTPase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">DCD-DUT</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">dcd</name>
        <name evidence="6" type="ORF">AA958_17560</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>dCTP + 2 H2O = diphosphate + dUMP + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:19205"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="3.5.4.30"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the dCTP deaminase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.30" evidence="3"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017016.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_17560"/>
    <dbReference type="EnsemblBacteria" id="AKH83712">
        <property type="protein sequence ID" value="AKH83712"/>
        <property type="gene ID" value="AA958_17560"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_17560"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3697"/>
    <dbReference type="OrthoDB" id="1598407at2"/>
    <dbReference type="UniPathway" id="UPA00610">
        <property type="reaction ID" value="UER00667"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033973">
        <property type="term" value="F:dCTP deaminase (dUMP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008829">
        <property type="term" value="F:dCTP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006226">
        <property type="term" value="P:dUMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006229">
        <property type="term" value="P:dUTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07557">
        <property type="entry name" value="trimeric_dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00146">
        <property type="entry name" value="dCTP_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011962">
        <property type="entry name" value="dCTP_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029054">
        <property type="entry name" value="dUTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036157">
        <property type="entry name" value="dUTPase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033704">
        <property type="entry name" value="dUTPase_trimeric"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00692">
        <property type="entry name" value="dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51283">
        <property type="entry name" value="SSF51283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02274">
        <property type="entry name" value="dCTP_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="dUTPase" evidence="5">
        <location>
            <begin position="72"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="165"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="101"/>
            <end position="106"/>
        </location>
        <ligand>
            <name>dCTP</name>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>dCTP</name>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="127"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>dCTP</name>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>dCTP</name>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>dCTP</name>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>dCTP</name>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for bifunctional activity" evidence="3">
        <location>
            <begin position="116"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH83712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="191" mass="21433" checksum="7DB4F8804AEB0FDB" modified="2015-07-22" version="1">MLLSDKDIRTEVDAGRVRIEPFEDAMIQPSSVDVRLDRYFRVFENHRYPHIDPAVEQSDLTRLVEPEGDECFILHPGEFVLASTYEVISLPDDIASRLEGKSSLGRLGLLTHSTAGFIDPGFSGHVTLELSNVATLPIKLWPGMKIGQLCMFRLSSPAEHPYGSAKYGSRYQGQRGPTPSRSYQNFHRTVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAY9</accession>
    <name>A0A0F7NAY9_9ACTN</name>
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        <submittedName>
            <fullName evidence="9">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AA958_23050</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017856.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_23050"/>
    <dbReference type="EnsemblBacteria" id="AKH84599">
        <property type="protein sequence ID" value="AKH84599"/>
        <property type="gene ID" value="AA958_23050"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_23050"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4858"/>
    <dbReference type="OrthoDB" id="856767at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
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    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519326" evidence="7">
        <location>
            <begin position="18"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="273"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="320"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="362"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="406"/>
            <end position="425"/>
        </location>
    </feature>
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        <location>
            <begin position="85"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH84599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="444" mass="45786" checksum="5EAA5FD8D7AEDE3C" modified="2015-07-22" version="1">MFSLAMRSIRQRPGRFAATLLSAFLGATIIMMFNSLLDTAGAKGVDDVSSESLSTAAMVVGGYGSLLVFFAVASTLTVAVRQRTAEIDLLRSTGATPAQITRMIVGEAAVVGLVGSLLAIVPGMTGGRILLDMFQDSGQVADDVDHAFGTIALMSGIDITLLASVGAAFLAVRRATKAREQRAPRRRLRTWGGYAALGLGAALCLTGFAMSDAGPEAMAPPAYGAILLSVGFAAFSPALLGGLLRLTGRLLTAFGGGSGYLTVHGLRQRAAQLSGVLMPMVLFVGISVATLYMQSVENDRIEAAGLTQSVDDKNLETLNFVVVGIIAVFACVMLINTLYAATSYRSREFGQQRLAGATPGQVLAGVGLEGLLLTVTGVFFGTLAAVAGIVPFTVARTDDVLPSAGYGIWLAVVGVAAAATMVTALGTTRRVLRTPAVETVALAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBH7</accession>
    <name>A0A0F7NBH7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AP_endonuc_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_28230</name>
    </gene>
    <organism evidence="2 3">
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        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_28230"/>
    <dbReference type="EnsemblBacteria" id="AKH85481">
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        <property type="gene ID" value="AA958_28230"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_28230"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5950"/>
    <dbReference type="OrthoDB" id="1194699at2"/>
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    </dbReference>
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        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="24"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="250" mass="26400" checksum="B694A3A8E00DF9D1" modified="2015-07-22" version="1">MSPSLGVQLYTVRDEIAADRPGTFAALAGFGYRQVECYDVLTDPEELRADLDTAGLAAGSVHAHVLAGPEQADAAFRGARTVGADTVFVPYLPPERFAGAEEVRAVAGELAEAAKRAAGHGLALGYHNHEFELSQHVGGVPALEVLADLLAGLDAPVQFEVDTYWAAVGGQDVPALLGRLGERVTHLHIKDGPVTKDDPMTAVGAGRMPVEDVLAAGAGARRHIVELDACATDMLTAVRESFDWLEGKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBW0</accession>
    <name>A0A0F7NBW0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_25030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84929.1"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_25030"/>
    <dbReference type="EnsemblBacteria" id="AKH84929">
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        <property type="gene ID" value="AA958_25030"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_25030"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5275"/>
    <dbReference type="OrthoDB" id="724641at2"/>
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    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13632">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="384"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="425"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="505"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="537"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="222"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH84929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="661" mass="71935" checksum="BFCD3DACEDB0E9C5" modified="2015-07-22" version="1">MRPEGYDYEKFSRLAGPLTDPDPSRPYRVRYTRLLSREPHRVRAVLLMALAPVLSCALLLYLVWPSHWTERTGAPPWLLTADAVMLISIGLIESFRLVNVVSIAHATMVARDPIPVTAEPGTRVAFLTTYVPGKEPLAMVRATLTAAVALRHDGPLDVWLLDEGDDPEARALCAELGVRHFSRKGVPQWNAEEGPHRAKTKHGNYNAWLAAYGDGYDFFASVDTDHVPLPNYLERMLGYFRDPDVAFVVGPQVYGNYDTAVTKFAESQQYLFHALIQRAGNAYGSPMFVGTNNAVRITALRQIGGLYDSITEDMATGFELHRTRNPATGRHWSSVYTPDVLAVGEGPTSWTDFFTQQLRWSRGTYETLIGQYGRGRGRFPLRRLLNYSLMLVYYPMTAVNWLLGALSCVLFLWLGSSGTQVPASIWLMLYSDAAALQIGLYLWNRRHNVSPHEPEGSGGLAGMLMSAMSAPIYFTSFKAAVLRRPCRFVVTPKGGDASPDRLATFRIHLFWAGLLAASFLASLVLGHTHVAMRTWTVLGAGIALAPVAIWVWSAWQVRSANRREDARRRADVAAAAAVRGRARGLRTRLWKPARAAEDAAAGAGGTAAPATAAPAATTATTATATTATATTTTATTATATATTATATATTATTTATTSGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NC87</accession>
    <name>A0A0F7NC87_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thiamine-monophosphate kinase</fullName>
            <shortName evidence="2">TMP kinase</shortName>
            <shortName evidence="2">Thiamine-phosphate kinase</shortName>
            <ecNumber evidence="2">2.7.4.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">thiL</name>
        <name evidence="5" type="ORF">AA958_25785</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + thiamine phosphate = ADP + thiamine diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15913"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine diphosphate from thiamine phosphate: step 1/1.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="2">Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the thiamine-monophosphate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.16" evidence="2"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018309.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_25785"/>
    <dbReference type="EnsemblBacteria" id="AKH85064">
        <property type="protein sequence ID" value="AKH85064"/>
        <property type="gene ID" value="AA958_25785"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_25785"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5431"/>
    <dbReference type="OrthoDB" id="1016556at2"/>
    <dbReference type="UniPathway" id="UPA00060">
        <property type="reaction ID" value="UER00142"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009030">
        <property type="term" value="F:thiamine-phosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02194">
        <property type="entry name" value="ThiL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02128">
        <property type="entry name" value="TMP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006283">
        <property type="entry name" value="ThiL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30270">
        <property type="entry name" value="PTHR30270"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005303">
        <property type="entry name" value="Thiam_monoph_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01379">
        <property type="entry name" value="thiL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AIRS" evidence="3">
        <location>
            <begin position="39"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="4">
        <location>
            <begin position="162"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="40"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>4</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="132"/>
            <end position="133"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>5</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH85064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="324" mass="33498" checksum="CBB53C76AC43B464" modified="2015-07-22" version="1">MRGHGQGQGTVGELGEFGLIRELTSRLTTTPAVRIGPGDDAAVISAPDRRVVASTDVLIEGRHFRRDWSTAYDVGRKSAAQNLADIAAMGAVPTALLLGLVVPADLLVTWPAELMDGLRDECQVAGAAVVGGDVVRGDAITLAITALGDMQGHEPVTRAGARPGDVVAVTGWLGWSAAGHAVLARGFRSPRAFVEAHRRPEPPYQAGPAAAALGATSMTDVSDGLLADLGHVAEAGKVRIDVRTAALDVPGQMADIGKAVGVDPLQWVLTGGEDHAIVATFPPQVKLPARWRVVGEVQAPSAAAQVTVDGEPWRGAAGWDHFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCK9</accession>
    <name>A0A0F7NCK9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Lysine N-acyltransferase MbtK</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Mycobactin synthase protein K</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_26635</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Acyltransferase required for the direct transfer of medium- to long-chain fatty acyl moieties from a carrier protein (MbtL) on to the epsilon-amino group of lysine residue in the mycobactin core.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Siderophore biosynthesis; mycobactin biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018451.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_26635"/>
    <dbReference type="EnsemblBacteria" id="AKH85214">
        <property type="protein sequence ID" value="AKH85214"/>
        <property type="gene ID" value="AA958_26635"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_26635"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5604"/>
    <dbReference type="OrthoDB" id="1538300at2"/>
    <dbReference type="UniPathway" id="UPA00011"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019290">
        <property type="term" value="P:siderophore biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019432">
        <property type="entry name" value="Acyltransferase_MbtK/IucB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM01006">
        <property type="entry name" value="AlcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="6">
        <location>
            <begin position="58"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="223"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH85214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="259" mass="27811" checksum="E7876BD56745DBFB" modified="2015-07-22" version="1">MSPDPPTPTRPPELLPDDTIDFGVGLARLLRGAARSPAPYDINCWSPAGTPAGPFRLVPVDPAEPERDLTLLHNWMNDPSVAAFWKLAGPVEVTARHVRAQWEAGHSVPCIGVLDGVRMSYWEVYRADRDPLAGYYRARPYDTGVHLLLGGGADRGRGLGSLLIRAVSDLVFAHEPRCGRVLAEPDVHNVPSVAAFLNAGFHFQEELAVPDKHAALMVRERALRDIDSDGHDDGGTRAGPAPPPGPSPSPPGPPRPGLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCZ1</accession>
    <name>A0A0F7NCZ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_32020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019309.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_32020"/>
    <dbReference type="EnsemblBacteria" id="AKH86081">
        <property type="protein sequence ID" value="AKH86081"/>
        <property type="gene ID" value="AA958_32020"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_32020"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6761"/>
    <dbReference type="OrthoDB" id="2084452at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH86081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="152" mass="15584" checksum="E9AAB1407631B8F7" modified="2015-07-22" version="1">MTSRDDTDIDDTGLDETEKTGNAGKTGIAAAGTDTGDLHTPGAGDSDETAGLPGPLDGEEGEDGEEPPPPRLTPRQARRVRALTSAGVMVAVGVAMVVRFRTEASLLTFALYGGALILSGTAIMLSRAGRTRVAMAVLAAGFAFVVADQLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDC7</accession>
    <name>A0A0F7NDC7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">UDP-N-acetylmuramate--L-alanine ligase</fullName>
            <ecNumber evidence="4 11">6.3.2.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">UDP-N-acetylmuramoyl-L-alanine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">murC</name>
        <name evidence="15" type="ORF">AA958_27925</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Cell wall formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>ATP + L-alanine + UDP-N-acetyl-alpha-D-muramate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine</text>
            <dbReference type="Rhea" id="RHEA:23372"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:70757"/>
            <dbReference type="ChEBI" id="CHEBI:83898"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the MurCDEF family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.8" evidence="4 11"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018663.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_27925"/>
    <dbReference type="EnsemblBacteria" id="AKH85429">
        <property type="protein sequence ID" value="AKH85429"/>
        <property type="gene ID" value="AA958_27925"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_27925"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5886"/>
    <dbReference type="OrthoDB" id="307881at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008763">
        <property type="term" value="F:UDP-N-acetylmuramate-L-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00046">
        <property type="entry name" value="MurC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000713">
        <property type="entry name" value="Mur_ligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005758">
        <property type="entry name" value="UDP-N-AcMur_Ala_ligase_MurC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01225">
        <property type="entry name" value="Mur_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01082">
        <property type="entry name" value="murC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6 11" id="KW-0132">Cell division</keyword>
    <keyword evidence="7 11" id="KW-0133">Cell shape</keyword>
    <keyword evidence="10 11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 11" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase" evidence="12">
        <location>
            <begin position="13"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_M" evidence="14">
        <location>
            <begin position="115"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_C" evidence="13">
        <location>
            <begin position="316"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="117"/>
            <end position="123"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AKH85429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="469" mass="47435" checksum="E4689DF676080D0C" modified="2015-07-22" version="1">MTPGIPPTLESPHFVGIGGAGMSGIAKILAQRGAAVAGSDARESGTVAALRELGAVVHLGHAAGHLDPGASAVVVSSAIREDNPELAAARARGLPVVHRSDALAAVMDGLRPIAVAGTHGKTTTTSMLAVALRSLGRDPSYAIGGDIDAPGSNAHHGTGDLFVAEADESDRSFHKYAPEVAIVLNVELDHHANYASLEEIYASFETFAARIVPGGTLVVSADHPGARELTGRLAASGVRTVTYGESPDADARVLSVTPKGLASEVAVVLGGAKLTFGVSVPGRHYAHNAVAALAAGAAAGVPAAELAPALASFTGVGRRLQPKGTAGGVRVVDTYAHHPTEMSADLEAVRAAADDGHGGRSGRILVVFQPHLFSRTRELGTEMGQALALADASLVLGIYPAREDPIPGVTSDIIIDAARAQGADVTFAPDMAAVPGLVAGMAKPGDLVLTMGAGDVTELGPRILSRLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDG0</accession>
    <name>A0A0F7NDG0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_27775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018637.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH85403">
        <property type="protein sequence ID" value="AKH85403"/>
        <property type="gene ID" value="AA958_27775"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_27775"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5855"/>
    <dbReference type="OrthoDB" id="1927273at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="215" mass="23221" checksum="87E6751ABBB32C6D" modified="2015-07-22" version="1">MTISRWGGGAAAVLGAALLLTSCGDSGDSGPDEIVGADRDPTQQSSTPTGEEPARDAPEFDFPADLKVEVDADTTGDGTKDAVLRDHGYAVRANMLALAELDPELPVLADYVTGDAFINSAENVESFKAEGRTVAGATHFYDREVELRNKGLASVTYCEDQRKAFNKDVDSGEVERTEPSDESFVRYKALMEKTDEGVWQMTFDQSERGAPECRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDQ9</accession>
    <name>A0A0F7NDQ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sugar ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_28490</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018762.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_28490"/>
    <dbReference type="EnsemblBacteria" id="AKH85528">
        <property type="protein sequence ID" value="AKH85528"/>
        <property type="gene ID" value="AA958_28490"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_28490"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6003"/>
    <dbReference type="OrthoDB" id="1378040at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519535" evidence="2">
        <location>
            <begin position="28"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_4" evidence="3">
        <location>
            <begin position="53"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH85528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="333" mass="34280" checksum="C6478DEB54D1F940" modified="2015-07-22" version="1">MARSTRVFAAVATATLLAVAAAGCSDSGGKDAEENDGGGGGGGGVNTPRMEIAMVTHSAPGDTFWDIVQSGSKQAAAKDNVEFLYANSEKDDEQARLVQTFVDKKVDGIIVTLAKPEAMKSAVQAAVDAGIPVVTINSGAEFSKEYGALSHIGQEEAVAGEAVGEELNERGRKNAVCVIHEQGNVGLEQRCAGVKKTFSGSVENLTVDGASKPAVLSGIQAKLEADGGIDSVVTLNADVAASAVEAKDASGSKAEVATFDLNAAVAASLESKQLSFAVDQQPYLQGYLAVDELWLYETNGNVIGGGQTVLTGPAIVTEEDAPDLKKFTERGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDR7</accession>
    <name>A0A0F7NDR7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thioesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_09970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019916.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_09970"/>
    <dbReference type="EnsemblBacteria" id="AKH86650">
        <property type="protein sequence ID" value="AKH86650"/>
        <property type="gene ID" value="AA958_09970"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_09970"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2099"/>
    <dbReference type="OrthoDB" id="1989068at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="161" mass="17564" checksum="A32F4E13C1EB42FF" modified="2015-07-22" version="1">MARHVYRCPLRWADMDAYGHVNNVEFLRYLEEARIDFMFRLAPGEGAGGGGTSFAGGSVVARHEIDYRRQLVHRYEPVTIEVWVTEIRAAAATLAYEVKDAPEDGGAVYAQASTVIVPFDFAAGRPRRITAEERAFLEKYLGPPPPAGSGKPGRPGEAAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDU2</accession>
    <name>A0A0F7NDU2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_28760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018806.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_28760"/>
    <dbReference type="EnsemblBacteria" id="AKH85573">
        <property type="protein sequence ID" value="AKH85573"/>
        <property type="gene ID" value="AA958_28760"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_28760"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6061"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="141" mass="14436" checksum="E0B3C46FA577442A" modified="2015-07-22" version="1">MSAAVSPTAASTPQITLRRWLGLDAVVTGANGLAYLALSGPVADLLGVDRGLLLVLGAVLVLYAADVAWLARKPVPPARLVALVVDINVAWAVASVVVLVTGVLDPTTAGYVWIPMQAAVVLGFAVVQYGLLRGLRAAAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDX7</accession>
    <name>A0A0F7NDX7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Beta-ketoacyl synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AA958_29295</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018888.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_29295"/>
    <dbReference type="EnsemblBacteria" id="AKH85659">
        <property type="protein sequence ID" value="AKH85659"/>
        <property type="gene ID" value="AA958_29295"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_29295"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6178"/>
    <dbReference type="OrthoDB" id="572620at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901362">
        <property type="term" value="P:organic cyclic compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="1 6" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="968"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="901"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="6">
        <location>
            <position position="1005"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH85659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="1102" mass="117398" checksum="FA19B773FAD25ECD" modified="2015-07-22" version="1">MTSPERTLVSADTLKNAYLTMERLQRRIEEYERARTEPVAVVGVGCRFPGGVTDTATYWRMLTGGVDAVGDIPADRWDHDAFYDEEAGKPGKIYTRSGAFIEGLDRFDHDFFGISRREALAMDPHQRLTLEVCWEALEDAGQAPSGLAGSDTGVFMGTASSDHVTSRIRHPEDVTAYTSSGAAASFVPARISYLLDLRGPNLAVDTACSSSLLAVHQACQSLRTGECDMALAGGVNVVLSPVLLISQSQFGSVSRQGRAMTFSDAADGYVRGEGCGVVVLKRLSDAVRDRDRILAVVRGGAVNQDGRSAGITAPNGAAQVGVYRRALAAGGVRPEQVGYIETHGTGTRLGDPIEAGALAEVYGRDHGAPVYLGAVKTNIGHLEAAAGIAGLIKAALCVSHGAIPPNLHFTRLNSNISFEGTTFDVPTRVTPWPETEGPRTAAVSSFGLSGTNVHMILEQAPSAPPVPADHRRPAGVLALSARTETALAALARRYADRLADGDGTPLADLCHSAATGRTHFRHRLAAVGTTRKEVADRLAGFLRGETRPGLAFGEARGSDVVFLFTGQGAQRPGMARVLYDTQPTFRRTVDECARILEPLLDRPLLSVLFPDDPEDRQINETAYAQPATFAVEYAMAELWRSWGVTPAAVLGHSFGECVAACVAGVMSPADGLAFTVQRARVIQEHSLPGTMAAVFAPEEEVAAEIAAHPDRIAVAAVNGPASTTISGDRDLVEAVCAAFAARGVKAKPLHIASAGHSPLMEPAVEPLRRAADKIAFAAPRIPLVSNVSGELWPWEQVPGADYWGRHVRDTVRFADGVQTLRDLGHRTFVEVGPAPTLLGVVSDALPPDHDDLLLPSLRPRHDDWEVLLETVAELYAAGVDIDWDGFDGDYTRTKAALPTYPFEPTRCWEPPRPWHGDRPAAPAAESTAEAGDDSRTRPARSSRRSSRNRRRPSRIPTATELRGLAEPEQLDTLAARFVLSVKDVLGSASGDVGLDEPLTGFGLDSLMAVELRNEIQDRLGLTLQITDFLGGATIRSVAERLVKELAATGGGSETDTPHDRSGAPAAIRRVPRAADTAAALLAEFTGPPQGPAAQNSGREGRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NE36</accession>
    <name>A0A0F7NE36_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_25070</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018188.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_25070"/>
    <dbReference type="EnsemblBacteria" id="AKH84937">
        <property type="protein sequence ID" value="AKH84937"/>
        <property type="gene ID" value="AA958_25070"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_25070"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5283"/>
    <dbReference type="OrthoDB" id="1437290at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011075">
        <property type="entry name" value="TetR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16859">
        <property type="entry name" value="TetR_C_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="17"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH84937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="226" mass="23751" checksum="DAB789C2C5C762CE" modified="2015-07-22" version="1">MSHETPAARRAGRPRSATADRAILDAARAAIAETGWAGVTLGGVAARAGVAKTTLYRRWPGKNELVLDALADLFDSLRLPDHGSLARDVEGVVLQFAELLREPRTRGALMAVLAEATQDAALRERIRDAIVDRQRHLVLLGRARAQARGELPVEPDAAAADRTADMIFDVIAGSVLHRLLVSAEPVTAAWATAFATLLTGGLAALTDPAPVPAPDPAAGSRDPSAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NE37</accession>
    <name>A0A0F7NE37_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 14">Pyruvate kinase</fullName>
            <ecNumber evidence="5 14">2.7.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">AA958_25095</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + pyruvate = ADP + H(+) + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:18157"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.40"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the pyruvate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.40" evidence="5 14"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018193.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_25095"/>
    <dbReference type="EnsemblBacteria" id="AKH84942">
        <property type="protein sequence ID" value="AKH84942"/>
        <property type="gene ID" value="AA958_25095"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_25095"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5289"/>
    <dbReference type="OrthoDB" id="1098983at2"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00188"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004743">
        <property type="term" value="F:pyruvate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.33.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001697">
        <property type="entry name" value="Pyr_Knase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018209">
        <property type="entry name" value="Pyrv_Knase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015793">
        <property type="entry name" value="Pyrv_Knase_brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015795">
        <property type="entry name" value="Pyrv_Knase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036918">
        <property type="entry name" value="Pyrv_Knase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015806">
        <property type="entry name" value="Pyrv_Knase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11817">
        <property type="entry name" value="PTHR11817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00224">
        <property type="entry name" value="PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02887">
        <property type="entry name" value="PK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01050">
        <property type="entry name" value="PYRUVTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="SSF50800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52935">
        <property type="entry name" value="SSF52935"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01064">
        <property type="entry name" value="pyruv_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00110">
        <property type="entry name" value="PYRUVATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12 14" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="9 14 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="11 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13 17" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PK" evidence="15">
        <location>
            <begin position="1"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="PK_C" evidence="16">
        <location>
            <begin position="356"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AKH84942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="474" mass="51276" checksum="BB40E6AC9C43EB0D" modified="2015-07-22" version="1">MRRAKIVCTLGPAVDSFEQLKALIEAGMSVARFNMSHGTQAEHQERYDRLRKAAEETGRPIGVLADLQGPKIRLETFAQGPVELARGDEFTITTEDVPGDRSICGTTYKGLPGDVSPGERILVNDGAVALEVLEVRGPEVRTMVIEGGVVSDHKGINLPGVAVNVPALSGKDVDDLRFALRMGCDMVALSFVRDAGDIGDVHRVMDEVGRRVPVIAKVEKPQAIDHMEEIVLAFDGVMVARGDLAVEYPLEKVPVVQKRLIEMCRRNAKPVIVATQMMESMISSSRPTRAEASDVANAILDGTDAVMLSAESSVGKYPIETVKTMSRIVVAAEDELLSRGLQPLVPGKKPRTQGGSVARAACEIADFLDAQTLVAFTQSGDTARRLSRYRACQPILAFTTDEHTRNQLTLSWGVEPVLVPHVNNTDAMVDLVDAELLKLNRFREGDTMVMTAGSPPGVAGTTNMVRVHHLGGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NEJ3</accession>
    <name>A0A0F7NEJ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_18685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020205.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86875">
        <property type="protein sequence ID" value="AKH86875"/>
        <property type="gene ID" value="AA958_18685"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_18685"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3918"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="166" mass="15815" checksum="2EB6B8E8C6809C24" modified="2015-07-22" version="1">MAVLALGGCMTVSGSGRPGAPDPGSGRSGTEPDGGVRVNDAPSAAAGGTGTREAGGARGPAGERDGDQKEPSATGRRSDGAADPESPSPGTREPADAGGTRGTPDPPRPTTPRPRPQPTTPSPTPTVPDPTPTPTPTPTPTPTGDDTTGGGAAAGAGGSSPRLPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NEL8</accession>
    <name>A0A0F7NEL8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glutamine synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_30365</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutamine synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019036.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_30365"/>
    <dbReference type="EnsemblBacteria" id="AKH85808">
        <property type="protein sequence ID" value="AKH85808"/>
        <property type="gene ID" value="AA958_30365"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_30365"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6415"/>
    <dbReference type="OrthoDB" id="416474at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamate-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="SSF54368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gln-synt_C" evidence="2">
        <location>
            <begin position="148"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH85808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="498" mass="53758" checksum="32E608BD7F481A71" modified="2015-07-22" version="1">MYSRKWRSPSGEESVGRPSFVADHDLWTDDQAAVADRIEAELGQLELVRLVYGDPHGLVRSKTLTVPAFRSVLRHGMNFSPGPFLFDTGHAVAVDFLGDPGIGVEEIAGAGNFILVPDPLTFQVLPGTEPRTAWVIGDEYLREGSPHPLSSRAVLRAVEKRYAVRGLDPLLGLEAEWYLTRRLDDEPGNEGNGFGTQGRAPRVAAVNAGYQFNLDFRYDSVAAVADPLAQCLTALGLPLRSMEHESGPGQVETTFAPMPPLDTADAMLLFRTVTKRLAARRGYHASFMSLPKLPSFDPSGWHLHQSVRESATGRNLFGAEGLSGGLSPEGKAYTDGLLSWARELLLLSVPTVNGYRRLDSAHTLAPTRIGLSVEDRTAMLRVAGGGANARIENRMGEPCANPYLNIAAQLFAGLDGLEGGAAGTPADPGAGLVPQSLRESFGAFRAGRAEQLLGAPLTACLTRLKESELDRFETWCAATGAPAGEVTDWEQREYFEAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NEN3</accession>
    <name>A0A0F7NEN3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_13580</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_13580"/>
    <dbReference type="EnsemblBacteria" id="AKH86741">
        <property type="protein sequence ID" value="AKH86741"/>
        <property type="gene ID" value="AA958_13580"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_13580"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2858"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH86741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="322" mass="31483" checksum="CE61E762DB7A9E11" modified="2015-07-22" version="1">MPADRAGAGQPQTLAGAHGGGYAGFGAPPPPPAGPPRRGRARGPLGLLAAAALVAAIVGGGSAALVGELTDSSGTSTSASSPASGTQVSSGNSGSVAGVAAAVSPSVVEIKSSSTAGQSTGSGVIVTESGEILTNNHVVSGAEQVQVTFSDGSTAAADVVGTDPDLDMALIKVQGKSGLKPATLGDSDSLKVGDEVVAIGSPEGLSGSVTSGIVSALDRDVTVEKEEGGQPQRGEQWPFGFGGGQYNGRLGPETTTYQAIQTDASLNHGNSGGALIDMQGRIVGINSAMYTPPDDSSAGSVGLGFAIPINDVKHILGDLRNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NF22</accession>
    <name>A0A0F7NF22_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNA polymerase sigma24 factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_31090</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Interacts transiently with the RNA polymerase catalytic core formed by RpoA, RpoB, RpoC and RpoZ (2 alpha, 1 beta, 1 beta' and 1 omega subunit) to form the RNA polymerase holoenzyme that can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019151.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH85923">
        <property type="protein sequence ID" value="AKH85923"/>
        <property type="gene ID" value="AA958_31090"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_31090"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6570"/>
    <dbReference type="OrthoDB" id="1335404at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="21"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="7">
        <location>
            <begin position="133"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH85923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="313" mass="33746" checksum="61864ADB5F02E4F6" modified="2015-07-22" version="1">MTTPSAQQPGRLDPGPAGIASERRRLTNLAYRLLGSLADAEDVVQETYARWYAMPAERRAAVVSPGGWLTKVAGRVCLDLLGSARVRRERYVGEWLPEPLPDRAELVGGRVGGAYADAVDPADLVTMDESVHMAFLVVLESMTPAERVAFVLHDVFRYPFPEVAGIVGRSPAACRQLASSARRRIRTARRPAAAEHHAALVREFRRAWAAKDIGALVGLLDPAATSTPDSGGLVPAVLRPVVGSESIARGLAEVREQQPGIELLERTVNGQPGVVARLDGVTVSVLAFAVADGRITRIWAMRNPEKLRAWTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NF24</accession>
    <name>A0A0F7NF24_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glucose-6-phosphate isomerase</fullName>
            <ecNumber evidence="3">5.3.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AA958_27350</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>alpha-D-glucose 6-phosphate = beta-D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11816"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="EC" id="5.3.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the archaeal-type GPI family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.9" evidence="3"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018567.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_27350"/>
    <dbReference type="EnsemblBacteria" id="AKH85332">
        <property type="protein sequence ID" value="AKH85332"/>
        <property type="gene ID" value="AA958_27350"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_27350"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5764"/>
    <dbReference type="OrthoDB" id="1276228at2"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00181"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004347">
        <property type="term" value="F:glucose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010551">
        <property type="entry name" value="G6P_isomerase_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06560">
        <property type="entry name" value="GPI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="5" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GPI" evidence="8">
        <location>
            <begin position="32"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF06560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH85332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="204" mass="21821" checksum="9C8D369EB7CBCFC7" modified="2015-07-22" version="1">MPSYASPPIEPSLITFDPRAGGMSPSGPVLTRRMSDLDGLFADGDAWRAAVRDGDPVVYDVASSPVPEAEGELPQSITTIRPGTVGGEFHMTKGHQHPNPQGEIYLGLAGTGGLLLFDGGRPRWIDMYPGAIGYIPPGWAHRSVNTGDEPYRFLAVYPGNAGHDYGWVLDHGMGYRVRRAPDGAPPLLVPFTASSPRTSPSNQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NF65</accession>
    <name>A0A0F7NF65_9ACTN</name>
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            <fullName evidence="4">Phytoene dehydrogenase</fullName>
        </submittedName>
    </protein>
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        <name evidence="4" type="ORF">AA958_32205</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
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        </lineage>
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    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="cofactor">
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            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP011492">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_32205"/>
    <dbReference type="EnsemblBacteria" id="AKH86114">
        <property type="protein sequence ID" value="AKH86114"/>
        <property type="gene ID" value="AA958_32205"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_32205"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6800"/>
    <dbReference type="OrthoDB" id="630753at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001613">
        <property type="entry name" value="Flavin_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017830">
        <property type="entry name" value="SQase_HpnE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00757">
        <property type="entry name" value="AMINEOXDASEF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03467">
        <property type="entry name" value="HpnE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amino_oxidase" evidence="3">
        <location>
            <begin position="19"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH86114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="481" mass="51103" checksum="29AC6B0C7B4B96DC" modified="2015-07-22" version="1">MADPGPDRRPRAVVVGGGLAGMTAAMGLADSGVDVTLLEGRPRLGGLAFSFRRGELSVDNGQHVYLRCCTAYRWFLDQVGGTGLAPLQERLDVRVLDAATTARKGPGPRTGTLGRTDLPVPLHLAAGLARYPHLSLAERASVGRAALAMRRLDPADPALDGVDFASWLHKHGQSPRAVSALWDMVGVATLNAFAPQVSLGLAAMVFRTGLLTERGAADIGWARVPLGELHDTLARRRLERSGTRIMMRTRATELRRGPAGGWQVDVATGPERAGGTPATLDADTVVLAVPQREAHGLLPAGALDHKDRLLEIGTAPILNLHVVYDRRVLHSPFVAAINTPVQWIFDRTDTSGLAGTPGGRGCQYVAVSQSAAQDDIERPVAELRERYLPELAKLLPDARGAEVRDFFVTRERTATFAPAPGVGRLRPGPRTHAPGLALAGAWTATGWPATMESAVLSGLAAVRETLGGLGREVPRNLLEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFA6</accession>
    <name>A0A0F7NFA6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_21885</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86956">
        <property type="protein sequence ID" value="AKH86956"/>
        <property type="gene ID" value="AA958_21885"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_21885"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4609"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH86956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="192" mass="22532" checksum="04384193E45252D5" modified="2015-07-22" version="1">MPLAPYYADFETHYWRSADLGFWKLERQQTFKEPGYDSWEAFAGGDWEESLRLLEAGREKLTRYHRKARQHGFTPRRIRVVEEPLSPYMQWELHALRVRAESGGRIHVIDADKVVQYESDSPLPEIYTLGSQVMYEAVYDRQGVLEAARKYVDRDLIMRCQSFIEELYQAGEPLLDWFDGHVAHLPPPPAQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFC1</accession>
    <name>A0A0F7NFC1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_32530</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019391.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_32530"/>
    <dbReference type="EnsemblBacteria" id="AKH86164">
        <property type="protein sequence ID" value="AKH86164"/>
        <property type="gene ID" value="AA958_32530"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_32530"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6866"/>
    <dbReference type="OrthoDB" id="1425840at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="229"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="3">
        <location>
            <begin position="5"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="3">
        <location>
            <begin position="141"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH86164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="304" mass="31229" checksum="220003ED3B5D97B7" modified="2015-07-22" version="1">MRWSVITAIAPVAWGTTYYVTGEYLPPERPLYGAAIRALPAGLLLLAVRRALPRGSWWWRSLVLGVLNMGGFFALVYVAAQRLPTSVASTVMATAPLVMTVLAWPLVREPPRARHLAAAVAGAAGVCVMLLTASASIDPVGVLASASAMAMSSCGYLLAKRWSDGADTLATTAWQLAAGGLILLPAAAAIEGRPPALDAPALLGFGYVALVATALAFVAWFAGLRRLPAATVGLVGLLNPVTGVLLGTAVAGETLTGRQLAGLALTLASVTLARPTTRRAERERTADAPRATSACPPGSRTAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFE2</accession>
    <name>A0A0F7NFE2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_32455</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_32455"/>
    <dbReference type="EnsemblBacteria" id="AKH87195">
        <property type="protein sequence ID" value="AKH87195"/>
        <property type="gene ID" value="AA958_32455"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_32455"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6849"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="70"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="149"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="195"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="218"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH87195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="260" mass="26434" checksum="C43AB51F5A252AC1" modified="2015-07-22" version="1">MLAAAHGGPALAVTAVTALLAVRADLQPLDAVVVTGAVFTGQLTIGWGNDLRDLSRDRVVGRTDKPLATGALPVGWVVRAVVTAALACLVLSMLCGWRSALVNVVLGTGAGHVYNLGLKATSWSWVPYVSGFGTLPSIVTLAGPTPVWAPLWMIGAGAALGVGAHLLNALPDLADDARTGVRSLPHRLGGRRSRVLAAVLLPAASLLAVLGPAGTPSWWAGVSLAPVAVLAVFTLVARGRTPFRAALAIALLDVVLLVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-12-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFH6</accession>
    <name>A0A0F7NFH6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_32090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019321.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86093">
        <property type="protein sequence ID" value="AKH86093"/>
        <property type="gene ID" value="AA958_32090"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_32090"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6775"/>
    <dbReference type="OrthoDB" id="1422015at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SpoU_methylase" evidence="2">
        <location>
            <begin position="50"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH86093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="184" mass="19962" checksum="B04468EC426442A2" modified="2015-07-22" version="1">MSARPGASRSGRDAPAIRTRTPREVKRSRRPRAHSCWDHLYAAPLWPLHGANLGTLLRTCDAVGACLVVPRFPWVPEALARGNTLRRPVCVHWTGDPLRWLERQRAAGKSVLGVELADEAVRLADLPAARRATVMVLGHEQHGIPQDALDLLDEAVEIPMVGTGASLNVAVAGSLVLYRLAGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFR9</accession>
    <name>A0A0F7NFR9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_33300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019519.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_33300"/>
    <dbReference type="EnsemblBacteria" id="AKH86294">
        <property type="protein sequence ID" value="AKH86294"/>
        <property type="gene ID" value="AA958_33300"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_33300"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.7033"/>
    <dbReference type="OrthoDB" id="1635052at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH86294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="131" mass="13993" checksum="6E0DAAF214FCF719" modified="2015-07-22" version="1">MKEAIQVAVSADELDREALVRYIEDGFVCAQACAECATACLQPAGAAEPGTVQRLDLRCADVCEQTARILSQHGRHDAPGLRAQVELCAATCAACAEDYERLAAEAPRAAERAAACRRCEQACHDFLVNLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NHE5</accession>
    <name>A0A0F7NHE5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_12625</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aromatic prenyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86723">
        <property type="protein sequence ID" value="AKH86723"/>
        <property type="gene ID" value="AA958_12625"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_12625"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2652"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033964">
        <property type="entry name" value="Aro_prenylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020965">
        <property type="entry name" value="Prenyltransferase_CloQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036239">
        <property type="entry name" value="PrenylTrfase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11468">
        <property type="entry name" value="PTase_Orf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00036">
        <property type="entry name" value="Aromatic_Prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01163">
        <property type="entry name" value="II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143492">
        <property type="entry name" value="SSF143492"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH86723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="299" mass="32733" checksum="D4CD9E3501F73884" modified="2015-07-22" version="1">MADKTEVEEVYSALEESARLVGAVCVRDKAWPVLDAFGAVVGEDLVVLGVQSGKRNAAELDFSFRVPGEIGNPYPYALEKGFVGETDHPVGTLLSDVGARFPVQEYYVDAGVVGGFKKLYAHFPLALQPLAALTDIPSMPEAVAENAGLFARYGLDKVAMVGVNYRANTMNLYFQFAPDNRPEPGALASMLREMGMPEPTEAVLRYVSAAMRANITLGWDSAHIFRVALAPPPSAGFEPAEIPAPMEPHMERFVREAPFAYEGERVNLIAVKWVPEEQFVEANSYYQLSPMLKKLTRGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NHF7</accession>
    <name>A0A0F7NHF7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">5-dehydro-2-deoxygluconokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_13345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020022.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_13345"/>
    <dbReference type="EnsemblBacteria" id="AKH86738">
        <property type="protein sequence ID" value="AKH86738"/>
        <property type="gene ID" value="AA958_13345"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_13345"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2807"/>
    <dbReference type="OrthoDB" id="1604782at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030830">
        <property type="entry name" value="Myo_inos_IolC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023314">
        <property type="entry name" value="Myo_inos_IolC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04382">
        <property type="entry name" value="myo_inos_iolC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="1">
        <location>
            <begin position="5"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="316" mass="32922" checksum="F70A5B740BA52C4B" modified="2015-07-22" version="1">MGRVGVDIYPLQTGVGLAEVSTFGKYLGGSATNVAVAAARYGHGAAVITKTGADPFGTFIRDALRGYGVGTDFVGTSPALPTPVTFCEIFPPDDFPLYFYRYPKAPDLDLAVDELDMDAVRAARVFWMTGTGLSEEPSRTATLAALEARGRTAHTVFDLDWRPMFWPEGAGASADGLARGLYRQALAHATVAVGNLEECAVATGEREPRAAARALLATGVELAVVKQGPRGVLAVHRDGAEAEVPPVPVEVVNGLGAGDAFGGALIHGMLEGWQLDRTIAFANAAGAHVAGELACSDAMPTAAQVEARLRAAETRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NHL9</accession>
    <name>A0A0F7NHL9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_20375</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_20375"/>
    <dbReference type="EnsemblBacteria" id="AKH86924">
        <property type="protein sequence ID" value="AKH86924"/>
        <property type="gene ID" value="AA958_20375"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_20375"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4291"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH86924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="143" mass="15753" checksum="7A1DC11667A79C7E" modified="2015-07-22" version="1">MTYKYFGAPDGATAARVPISMRPEELGGDELGQGGLFAKVKPETMSAMVLTGIEGIPLHKVPPLELVVLHPDYAVVRLPMTVVDPLRGIGEEEVGAAAFIWSTVPDRGGPRDAFDVYRMLHEWQEFADRLHEAGHQPYCLVWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NHN0</accession>
    <name>A0A0F7NHN0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Siderophore biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_33075</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IucA/IucC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_33075"/>
    <dbReference type="EnsemblBacteria" id="AKH86252">
        <property type="protein sequence ID" value="AKH86252"/>
        <property type="gene ID" value="AA958_33075"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_33075"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6987"/>
    <dbReference type="OrthoDB" id="856726at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016881">
        <property type="term" value="F:acid-amino acid ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019290">
        <property type="term" value="P:siderophore biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Aerobactin_biosyn_IucA/IucC_N"/>
    </dbReference>
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        <property type="entry name" value="FhuF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037455">
        <property type="entry name" value="LucA/IucC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34384">
        <property type="entry name" value="PTHR34384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06276">
        <property type="entry name" value="FhuF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04183">
        <property type="entry name" value="IucA_IucC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="163"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="FhuF" evidence="4">
        <location>
            <begin position="415"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="599"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH86252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="622" mass="64680" checksum="464CFD6172986B28" modified="2015-07-22" version="1">MTGAAPDSGAGVDAEEAELTLRVLSALLREDAAGLRTRTTAHDRADGRWLRLADSAGPGALLLPVAPDGFQGAYCARLPLLLRECGAATAEITGLDAVLAALAGRAEPEDRGGFAGVAAECRQALAAARLHAATRDGTAAALTARYGAEPARWTGHAGTLAYDTLAARLDHPVYPASRARAGLTEAELRAYAPEFHPRFALRWLALPYDALTLRGALDPAAAPDPPAAWPAPSTLGLPAALDRTHLALPVHPLTLGGPLDGALRATGLAARAALAPVPYLDVVPTLSMRTVASAADPRLHLKLPLATATLGLRNRRTVKPATLADGATVQRLLEAVVRREPRFRETVLHADETAYAHAGHDLLAALCRRQPAGLDGALVVPLAALLAPAPGGGLVADHLADRWYGGDPLALLDGLLTPLFDFQTTLFGYGVALESHQQNVSLVLDQPGRTAGGRPRVRLLFKDDDGPRIHHARLRAALGPDAPGPGDFADPRTLCDGDAPVADVFATITVHLCAGAYAFGLARHGRAPLAALLALVRDRLAGAVARLGTGPGEPGAVLRAHVLTAGHLPVKAMVTSGTLMSKERSGAADINKHYTTGPNYLRAAAPGPRPGTVPYPSTGWNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NI93</accession>
    <name>A0A0F7NI93_9ACTN</name>
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        <submittedName>
            <fullName evidence="1">Dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_01370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86482">
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        <property type="gene ID" value="AA958_01370"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_01370"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.301"/>
    <dbReference type="OrthoDB" id="1261526at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH86482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="227" mass="23941" checksum="5CBC23EF002C07C5" modified="2015-07-22" version="1">MTTLALVGAGPGLGLATARRFGREGFDIALISRSQDRLDALAAELDRDGVRARGFTADVREHRSLTAALDAATATLGVIEVLQYSPVPHADFMKPVLDTTTTDLDAPLAFSVKGPVACVNAVLPGMRDLGRGTLLFVNGGTAVRPRPDRAGTSIAFAAESAYAAMLHDALAPDGIHAAQLIIPGAIRPDAEYSSPTALAERLYTIHTERGTFRHYAEPMPEPQDGSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NID4</accession>
    <name>A0A0F7NID4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_32950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020645.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_32950"/>
    <dbReference type="EnsemblBacteria" id="AKH87204">
        <property type="protein sequence ID" value="AKH87204"/>
        <property type="gene ID" value="AA958_32950"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_32950"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6962"/>
    <dbReference type="OrthoDB" id="1818898at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH87204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="237" mass="25311" checksum="958E12AEF12DA49C" modified="2015-07-22" version="1">MAGRVLGALRGTRVPLPAVSHADRPADATALAAVRVLGPDLFAPALFCRQPLPQPDRETLGSALRVFPPRPGDSTEARWRDRTTAALLARGAAGARAAVPYAEEDSERAAIAEVVEIAGFAEDAEDTELTWQERSQRMARLAPLALPEVDGPYQQRACLHVRALSQGAVRSLMRRDHPTAARLVRWLALAQSRGASPALDVPTALEHLRLWGAPNARTALDLAIAGRLLAAAEGGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NIL8</accession>
    <name>A0A0F7NIL8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_29605</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020521.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_29605"/>
    <dbReference type="EnsemblBacteria" id="AKH87118">
        <property type="protein sequence ID" value="AKH87118"/>
        <property type="gene ID" value="AA958_29605"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_29605"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6248"/>
    <dbReference type="OrthoDB" id="2091761at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045512">
        <property type="entry name" value="DUF6480"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20088">
        <property type="entry name" value="DUF6480"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH87118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="77" mass="7781" checksum="B131F7932DF177FD" modified="2015-07-22" version="1">MPASNPDPDPDRTTGLEPGGSVPPGETPPAEGSTPGAGPDETHNPTKGWAKGPLFLIGLVVVLFAVGYVGYALALTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NJY2</accession>
    <name>A0A0F7NJY2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_28700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020487.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH87092">
        <property type="protein sequence ID" value="AKH87092"/>
        <property type="gene ID" value="AA958_28700"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_28700"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6049"/>
    <dbReference type="OrthoDB" id="1611562at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1800.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004211">
        <property type="entry name" value="Endonuclease_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038563">
        <property type="entry name" value="Endonuclease_7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044925">
        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02945">
        <property type="entry name" value="Endonuclease_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54060">
        <property type="entry name" value="SSF54060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH87092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="177" mass="19121" checksum="45DEEE85AD173EAA" modified="2015-07-22" version="1">MSSTPPPGREVPACHEWTPPGAAPALVPAAGPGGALGAIRRWQDGRCAVCGLRPARLVVDHHHVSGLVRGLLCDSCNVAEGRRTSSYAEPYASYRRRPPALIVGLTERYPHWRPNAYHYVLGDPPDDPALAARVLGHLIRHPPRRPTGRPVEIPGLPGHYLVGDGMRRLAERLAAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NJZ9</accession>
    <name>A0A0F7NJZ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_29350</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AKH87112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
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    </evidence>
    <sequence length="422" mass="42228" checksum="421F510590D5E3D5" modified="2015-07-22" version="1">MPHAGPGKVQAPLRRACGASGPLRQSVLPALCVTEIVSWGVLYYAFPVLAPQISQNTGWSSPSVAAAFSGALIVSALAGIPLGRVLDRRGPRKIMTGGSLLAVPAVVAVALAPSLPLFTIAWLVCGLAMSATLYPPAFAAVTGWFDGTQRTRALTTVTLVAGLASTVFAPLTATLADHMSWRTTYLVLAAVLAVVTVPLHALCLRAPWPAPSGHAAAGLTAAAGRRPESAVPRTRPFLLLGLSMALASFAFAAAVVATVPLLTNRALSSEAAAWALGLGGVGQVLGRLGYAALVRRVGVRARTVLAYSLGGLTTLALGIAPGPMPLLIAASMAAGAVRGVATLLQATAITDRWGAQSYGTLSGLLSAPAVAATALAPWAGAGLAVLLGGYPALFALLAALLGAAAVLAAGSVPRKATGASTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NK06</accession>
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    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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    <dbReference type="EnsemblBacteria" id="AKH87122">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <begin position="446"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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    </evidence>
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        </source>
    </evidence>
    <sequence length="883" mass="94701" checksum="3CB416DDB283462D" modified="2015-07-22" version="1">MPAATADEQELSIDLAAGTGAFHGGAAGTLYGLYGQDVPTNNLIEGMNLRTVSTKAQDGPQHPGADALDVVKPLADSTGGDVYIYMTDIHRGFPYQWEGDTPGEKVSIYREKIAKQVDQVLELPEEYRDNIVFVPFNEPEGNMFGTGEWSYDRTSWLDDPADYFATWDDFYRLIKGKMPGARIAGPNTSILYDQVKGFLEHTVEAGTVPDVVTWHELSHPEQVRTSVATYRAWEKEVFAGTAYEEKTPLPVNVNEYAFNYHTSVPGQMIQWISAIEESKVDADMAYWNIDGNISDSAVQSNRGNGQWWLFNAYGAMSGHTVEVTPPSPGENYTMQGVATLDEEKRQARALFGGADGPSRVRFDNVPAAVFGDTVHAWVREIPWTGQIGDSDRPEPVAEGDADVQDGAVEFDFGGDLPELEESSAYEIVLAPGGGGDASPPRALWQGSYEAEDAAHTGSGYSLNGPEGSPKEVSKFYTSGGYNVGGLRTGSDVRLDFTVDVPADGTYDLRVFANSLNTYGLVAEQGPTNVFLRVDGEDEQELHLPLGYKWVVWDHADTTVELTEGEHTLSLAARSLDGTGATKGDAIIDRITLSQPAATADQAVYEGELASFDGGGPVYDLPQDGSTTGAGAARLADGESATFWVYSEADAEARLGVAALGGGRSRLAVNGQDVQNVTRASGEVAVSLSGGVNKVTVTATAGTVLIDHLAVAPGGGVLEPREYQAEAAELAGTAEVADFSLADGGKAVQGVGGEPGNGNTATFRVTADTAGLYAMRVRYANPEQSEATHYNPDPLVRHADVSVNGGEARRVTFPHSFHENNFWDLTVPVRLERGDNTIAFRAEELPNFDGESYASDTWPGVLLRSQYAPVLDRITLAPYAVGQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MYA5</accession>
    <name>A0A0F7MYA5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_02380</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH81210">
        <property type="protein sequence ID" value="AKH81210"/>
        <property type="gene ID" value="AA958_02380"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_02380"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.510"/>
    <dbReference type="OrthoDB" id="1290978at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005330">
        <property type="entry name" value="MHYT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03707">
        <property type="entry name" value="MHYT"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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        </location>
    </feature>
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        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="MHYT" evidence="2">
        <location>
            <begin position="9"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH81210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="259" mass="26394" checksum="5BDD77DE0788E17C" modified="2015-07-22" version="1">MGHLDHAAYGWLTPVLSYAMACIGAALGLRCTVQALAAPTARSRRNWLLTAASATGTGIWTMHFIAMLGFTVSGTEIRYDIQRTVLSLVVAMAVAGAGVFALGHLRARGPALLVAGLATGLGVAAMHYLGMSAVRLHGSIAYDLPAVVLSVLIAVATATAALWAALTIRSPLAVTLASLVMGAAVTSMHYTGMAAVSVSVMPSPEALAGATATQFVFPLTVGLGSYLFLTSAFVALTPTAAERAATVSAQRLTRAPGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MYW8</accession>
    <name>A0A0F7MYW8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_03785</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014813.1">
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_03785"/>
    <dbReference type="EnsemblBacteria" id="AKH81455">
        <property type="protein sequence ID" value="AKH81455"/>
        <property type="gene ID" value="AA958_03785"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_03785"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.796"/>
    <dbReference type="OrthoDB" id="1827824at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAS" evidence="4">
        <location>
            <begin position="18"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="3">
        <location>
            <begin position="140"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH81455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="361" mass="39140" checksum="08DCAF4C5ED791AB" modified="2015-07-22" version="1">MESADDGPGVKDLGCAPDDLPDGLVVADEHGVVVRFNAAAARITALEPAAVLGRPLAEALPLEDLKGRRWWRLTDPYGGLAIRTGHPERNLLLPGNREVLVAARYVRDGRTGPVRKLVVTLRGTEARRRSERSHAELIATVAHELRSPLTSVKGFTATLLAKWERFTDDQKRLMLETVHADANRVTRLIAELLDISRIDSGRLEVRKQRVDVVAAVHRHVEAQTTAGQDPARFRTLVPGELPELWADPDKVDQVLGNLLENAVRHGEGLVTIEVAPATLTHGREGTQVTVSDEGPGIPEESMSRVFTRFWRGSKRGGTGLGLYIVKGIVEAHGGIITVGRAPGGGARFRFTLPVGAPAHLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MYY6</accession>
    <name>A0A0F7MYY6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidyl-prolyl cis-trans isomerase</fullName>
            <ecNumber evidence="4">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_03970</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the FKBP-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014842.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_03970"/>
    <dbReference type="EnsemblBacteria" id="AKH81485">
        <property type="protein sequence ID" value="AKH81485"/>
        <property type="gene ID" value="AA958_03970"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_03970"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.833"/>
    <dbReference type="OrthoDB" id="1861282at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="5">
        <location>
            <begin position="35"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH81485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="124" mass="13014" checksum="EA524A2E1A8F8F60" modified="2015-07-22" version="1">MSIDKPEVDFPEGPPPADLEVQDLWEGDGPVAKAGDTVSVHYVGVAFSSGEEFDASWNRGKPLQFQLGAGQVIPGWDQGVAGMKVGGRRRLTIPPHLAYGEAGAGGGRIKPGETLIFVCDLVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MZJ8</accession>
    <name>A0A0F7MZJ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cobalamin biosynthesis protein CbiX</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_05395</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015079.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_05395"/>
    <dbReference type="EnsemblBacteria" id="AKH81725">
        <property type="protein sequence ID" value="AKH81725"/>
        <property type="gene ID" value="AA958_05395"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_05395"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1131"/>
    <dbReference type="OrthoDB" id="1573073at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002762">
        <property type="entry name" value="CbiX-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01903">
        <property type="entry name" value="CbiX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="271"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="281"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH81725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="312" mass="33116" checksum="3D7897E9A2AC44FB" modified="2015-07-22" version="1">MTKPALLIAGHGTRDAAGAEAFRAFVRVLAERHPGLPVAGGFIELSPPPLGEAVAQLVARGVRHFAAVPLMLVSAGHAKGDIPAALAREKGRHPGLSYAYGRPLGPHPKLLAVLARRVAGAQRTERARTTVLLVGRGSTDPDANAEVHKAARLLWEGRGYAGVETAFVSLAAPDVAAGLERCRRLGAEHVVVLPYFLFTGVLPERVAHQARQWAAAHPGVVVRTADVIGPEEELVELVTERYEEAVAGDLRMNCDSCVYRVALPGYEAKVGAPQQPHFHPGEDGTAHDHGPGHGHVHTHGPGYHHGDHAHAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MZP9</accession>
    <name>A0A0F7MZP9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Export associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_05770</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015143.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_05770"/>
    <dbReference type="EnsemblBacteria" id="AKH81790">
        <property type="protein sequence ID" value="AKH81790"/>
        <property type="gene ID" value="AA958_05770"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_05770"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1208"/>
    <dbReference type="OrthoDB" id="355053at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd06974">
        <property type="entry name" value="TerD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003325">
        <property type="entry name" value="TerD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02342">
        <property type="entry name" value="TerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TerD" evidence="2">
        <location>
            <begin position="65"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH81790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="686" mass="71065" checksum="306DBFCBDD226151" modified="2015-07-22" version="1">MTAELVRGQNHLLPQTRVEIRISAGCPVTPGATLGGQDGRLSDPGRIAHPGATQLPGLEVPGQAAAEHRLAVDLDAVPPDVERVHVLLALPAGVPGPRNFGAIAPPSVAVTGLDGTAIARFVITGLDSESAVTAVELYRRGDAWKIRAVGQGYAGGLAAMLADQGLPEAQQLAADIERAVAEGLARAVAPAPPPVTGQPTGPGARRPQQAAEERQTQAGPVDYRHPRRAAAGAAGASGGSSGGPGTPGASGAPRAPASAAAPPPPGVGAGAGAGARPGAAAGAGSAAGGVPPQSGRPQSGPAAPVAGDAPGWSMEERLYNQVWGMFEDLARTVAAYRSAVDFADSRMDRELDQLLADPRARMGSIADSARAEVLARHSTLVDRAREVLDRDLGQLVAEAGVVEPALPPAFASWASPVWHEYEVPEDAPMALRLGDLHLPEHTELRVPLLVRLPLQRGLWVDSGTSSLGPGALEGDPEHGFPDSAERRALALDTAVAHASRLLSVHPAGEFNVHFIDPGGTATTALTPLLHSGVLAEPPPKGAAAVTDTLSRLTQRIDLVQMALRSGAADALPPDLDPAQQLLVVNDFPHGFDDRAINQLRYLADEGPSVGVHLLVVADREDAKGYGPLLDPFWRGMLRLTPTPDDHLADPWIGHAWTYEPARAPMGSRVLEQVLAQVAAARRALRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N015</accession>
    <name>A0A0F7N015_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_06440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015258.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH81905">
        <property type="protein sequence ID" value="AKH81905"/>
        <property type="gene ID" value="AA958_06440"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_06440"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1345"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="61" mass="6680" checksum="DBDDBB56D15DEFCD" modified="2015-07-22" version="1">MSRKNRNRQNDRAASPQEERGTETDSPSAGGPPPDQVSEAVNPGSGSHKTQKHKEKRFGHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0N2</accession>
    <name>A0A0F7N0N2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Adenosylmethionine-8-amino-7-oxononanoate aminotransferase</fullName>
            <ecNumber evidence="4">2.6.1.62</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">7,8-diamino-pelargonic acid aminotransferase</fullName>
            <shortName evidence="4">DAPA AT</shortName>
            <shortName evidence="4">DAPA aminotransferase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">7,8-diaminononanoate synthase</fullName>
            <shortName evidence="4">DANS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Diaminopelargonic acid synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">bioA</name>
        <name evidence="6" type="ORF">AA958_00935</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only aminotransferase known to utilize SAM as an amino donor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(8S)-8-amino-7-oxononanoate + S-adenosyl-L-methionine = (7R,8S)-7,8-diammoniononanoate + S-adenosyl-4-methylsulfanyl-2-oxobutanoate</text>
            <dbReference type="Rhea" id="RHEA:16861"/>
            <dbReference type="ChEBI" id="CHEBI:16490"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:149468"/>
            <dbReference type="ChEBI" id="CHEBI:149469"/>
            <dbReference type="EC" id="2.6.1.62"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; biotin biosynthesis; 7,8-diaminononanoate from 8-amino-7-oxononanoate (SAM route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.62" evidence="4"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH80968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014334.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_00935"/>
    <dbReference type="EnsemblBacteria" id="AKH80968">
        <property type="protein sequence ID" value="AKH80968"/>
        <property type="gene ID" value="AA958_00935"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_00935"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.207"/>
    <dbReference type="OrthoDB" id="478143at2"/>
    <dbReference type="UniPathway" id="UPA00078">
        <property type="reaction ID" value="UER00160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004015">
        <property type="term" value="F:adenosylmethionine-8-amino-7-oxononanoate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00834">
        <property type="entry name" value="BioA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005815">
        <property type="entry name" value="BioA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00508">
        <property type="entry name" value="bioA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-0093">Biotin biosynthesis</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="4">
        <location>
            <begin position="121"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="4">
        <location>
            <begin position="318"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="401"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM" evidence="4">
        <location>
            <position position="22"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4">
        <location>
            <position position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH80968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="434" mass="46556" checksum="A3F3D99F8E486261" modified="2015-07-22" version="1">MPEPLPPRRLLDLDREHVWHPYGPMPGRQEPLVVDSAEGVRLRLAQPAWGVDELVDGMSSWWSAIHGYRHPALDAAARGQLERMSHVMFGGLTHEPAVRLAARLVEVTPEPLEHVFLSDSGSVSVEVAVKMCLQYWRSRGLPDKRRLMTWRGGYHGDTWQPMSVCDPDGGMHELWSGVLPRQLFAGVPPAGFDAPVDGAYERELRDLVARHADELAAVIVEPVVQGAGGMRFTAPGYLRVLREACDEHGVLLVFDEIATGFGRTGAFFAADHAGVTPDVMCVGKALTGGYLSMAATLCTPAIAEGISRGEVPVLAHGPTFMGNPLASAVALASLDLLADGGWRQDVKRIESGLREGLAEAAELPGVRDVRVVGAIGVVQLDHDVDMAAATRAAVGAGVWLRPFRDLIYTMPPYVTGDADLARICAAVRAAAAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0S9</accession>
    <name>A0A0F7N0S9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_04645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_04645"/>
    <dbReference type="EnsemblBacteria" id="AKH81601">
        <property type="protein sequence ID" value="AKH81601"/>
        <property type="gene ID" value="AA958_04645"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_04645"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.979"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="166"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="303" mass="33312" checksum="33B614E74A39D925" modified="2015-07-22" version="1">MSVLVRDFRPEDADAVAEVQRAAVPFLVTTPESVRWNVASAPPEKRLRALVAEVGGKVVGECEAFVQYDSSTPGQGIAQPYVHPGHTGRGAGSALVAAAEAHLAARGVTTVYTWVYDTERDLGFAERRGYRRGRTGRILHLDLRAALPPRREPAADVELRAFADFDDPRPLYEADAEAALDEPSDTPADAMSYEHWLDHTWREPLLDRDLTIAALVDGEVAAFSLAETDGRTRYLSGMTGSRRAFRGRGLAKLAKHESLLRARAAGYTDAFTGNDSGNEPMLAINRWFGYEPFLTELRCIKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0Y5</accession>
    <name>A0A0F7N0Y5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycoside hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_01325</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014394.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_01325"/>
    <dbReference type="EnsemblBacteria" id="AKH81029">
        <property type="protein sequence ID" value="AKH81029"/>
        <property type="gene ID" value="AA958_01325"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_01325"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.293"/>
    <dbReference type="OrthoDB" id="419160at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019800">
        <property type="entry name" value="Glyco_hydro_3_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="SSF52279"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00775">
        <property type="entry name" value="GLYCOSYL_HYDROL_F3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fn3_like" evidence="4">
        <location>
            <begin position="628"/>
            <end position="699"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH81029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="710" mass="74961" checksum="9BEE41424659DBD9" modified="2015-07-22" version="1">MLGPHEGKVKDLISRMTVEEKLGQLQQLTWTGATGPGGGQTEEVERAARAGLLGSVLNLHGARHTNSLQRMAVEESRLGIPLLFAQDIIHGFWTTFPIPLAQAAAFDPAVVERDAVVSAKEARSNGVRWTFSPMMDVTHDPRWGRIAESCGEDPYLNGELAAAKVRGYQGDDLAADGSLAACAKHFVAYGGAEGGRDYNTVDVSEQRLRNHYLPPFKAAVDAGVATVMAAFNTVSGVPAHGNSHTLTGILKEEWGFDGLVVSDYTGVEELIAHGYAADGADAGRLALTAGIDMEMVSTRIATHGAQLLAAGRIREDRIDDAVARVLHLKFTLGLFDDPYTDEDAAIDGPTPEARAAARETATRSMVLMKNDGVLPLDRGLRSLAVVGPFADSTDLHGTWAGPGCRRFPSVSVLDAVRAAAPGAEVAHAGADPAEAAAAAGAADATVVVVGEAAELSGEAAVRSDISLPAGQRELIAAVAATGKPFAVVLVNGRPLTIGDWSGEVPALLEAWHPGIEAGNAVADVLFGAVNPGGKLPVTFPRSVGQIPLYYNRESTGRPYDPAEKYTSKYLDVADGPQFPFGHGLSYTVFRTGQPRPVRDTVTTGALERGERIGIEVDVTNTGERAGDEVVQLYVHDPVASIAQPVRRLRGFSRVTLGPGEKRTVRFTLGAEDLGFWTNDTAGRYVVEPGRIDVYAGSSSLAEARCTLTIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N1N8</accession>
    <name>A0A0F7N1N8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Glycerol-3-phosphate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AA958_02895</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_02895"/>
    <dbReference type="EnsemblBacteria" id="AKH81294">
        <property type="protein sequence ID" value="AKH81294"/>
        <property type="gene ID" value="AA958_02895"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_02895"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.619"/>
    <dbReference type="OrthoDB" id="360065at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009331">
        <property type="term" value="C:glycerol-3-phosphate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004368">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006072">
        <property type="term" value="P:glycerol-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.870">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031656">
        <property type="entry name" value="DAO_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038299">
        <property type="entry name" value="DAO_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000447">
        <property type="entry name" value="G3P_DH_FAD-dep"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11985">
        <property type="entry name" value="PTHR11985"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16901">
        <property type="entry name" value="DAO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01001">
        <property type="entry name" value="FADG3PDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="7">
        <location>
            <begin position="45"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="DAO_C" evidence="8">
        <location>
            <begin position="427"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH81294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="539" mass="55551" checksum="BDFD9043A041AB3B" modified="2015-07-22" version="1">MTVQPAGGPAGPSAASAADAPRDFSLNARRRTRELAALAAGERVDLLVVGLGATGAGVALDAAARGLSVAAIDAHDLAFGTSRWSSKLIHGGLRYLASGQVGIARECAVERGALLEHIAPHLVHAQPFVIPLTPLTTRAQAAVAWAGLRSGDLLRAAARTSRAALPPPRRLSAVETGQLVPGLRRYGLRGGLLSWDGQLTDDARLVTAVARTAAGYGARVLTRVRAEELTGTGAVVRDETTGERLRIRARAVVNAAGVWAGSLVPGVRLRPSRGTHLVLRAEALGMGRQPGGAGVHIPIPGATGRFALVLPQDDGRVYVGLTDEPVDGEVPDVPAAPETDVGFLLDVLDSALDVPVRRSDVVGAFAGLRPLLESDGSTADLSRRHAIRTSPDGVVTVVGGKLTTYRRMAEDAVDTAVSCAGLTAGPCRTARLPLVGAAPAAELAGLDAPRRLVQRYGTEAPAVQALAAAEPALAAPVVPGYPVTGAELVWAVRHEGALDEADLLDRRTRLGLVAAERAAAVAAAREVLSAVRSAVRPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N1Q5</accession>
    <name>A0A0F7N1Q5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_03165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014702.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH81343">
        <property type="protein sequence ID" value="AKH81343"/>
        <property type="gene ID" value="AA958_03165"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_03165"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.675"/>
    <dbReference type="OrthoDB" id="2079705at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519069" evidence="1">
        <location>
            <begin position="22"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="65" mass="6639" checksum="AB28797762453F71" modified="2015-07-22" version="1">MAVAMVAAPAGVGLQGGVAAADEHYNGGSVSNGSSFALLRTGQIDDPMEDVLEHFLLLGGNHTWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N1X4</accession>
    <name>A0A0F7N1X4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pyridoxamine 5'-phosphate oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_03605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014781.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_03605"/>
    <dbReference type="EnsemblBacteria" id="AKH81423">
        <property type="protein sequence ID" value="AKH81423"/>
        <property type="gene ID" value="AA958_03605"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_03605"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.759"/>
    <dbReference type="OrthoDB" id="1885467at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="1">
        <location>
            <begin position="9"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="194" mass="21289" checksum="E9216FF1D1F494CB" modified="2015-07-22" version="1">MGKTYERIDGRLRAFIEAQHMFFTATAPLAADGTVNLSPKGLTGSFAVLDERTVAYLDFAGSNAETIAHLRENGRITLMWCAFDGPPNIVRVHGSGEAVFRDDPRFPALLGHFPAIDPSRHGLRAIVVVTAELIRDTCGYAVPFMTYEADRDLHARRFAREDDAGLDAYFRKKEHIAASIDGLPGLPLPLPPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N261</accession>
    <name>A0A0F7N261_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Non-homologous end joining protein Ku</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ku</name>
        <name evidence="5" type="ORF">AA958_07445</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer. Interacts with LigD.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the prokaryotic Ku family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_07445"/>
    <dbReference type="EnsemblBacteria" id="AKH82091">
        <property type="protein sequence ID" value="AKH82091"/>
        <property type="gene ID" value="AA958_07445"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_07445"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1560"/>
    <dbReference type="Proteomes" id="UP000034283">
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        <property type="evidence" value="ECO:0007669"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR006164">
        <property type="entry name" value="Ku70/Ku80_beta-barrel_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009187">
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    </dbReference>
    <dbReference type="InterPro" id="IPR016194">
        <property type="entry name" value="SPOC-like_C_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41251">
        <property type="entry name" value="PTHR41251"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02735">
        <property type="entry name" value="Ku"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006493">
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00559">
        <property type="entry name" value="Ku78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100939">
        <property type="entry name" value="SSF100939"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02772">
        <property type="entry name" value="Ku_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="2" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ku" evidence="4">
        <location>
            <begin position="52"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="257"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="305"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH82091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="325" mass="35205" checksum="55C9A0B374364477" modified="2015-07-22" version="1">MKSIWKGAISFGLVSIPVQLYSATEERGVSFRQVHAADGGRIRYRRFCELEDREVQYAEITRAYETEDGELVVLTPEDLAELPLPSKKIIDVVGFEEVGYFDPIQFSRAYYVKAADAAAAKPYVLLREALKRSGRVAVVKVALRNREAPALVRVLAEEDVLVLHTMLWPDEVRSAQAVAPDEKVTVRRQELDMVDSLMDALGGYDPEEFTDEYREAVEALVASKEGIAPLPKEAAAGEERGQVIDLMSALEASVQAAKDKRGGTAAPRKKAAAKKATGKKTAAKKATGKTAGTKKAAAKKTGTAGKKTAAKKTAKKTTKKPGKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N274</accession>
    <name>A0A0F7N274_9ACTN</name>
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        <submittedName>
            <fullName evidence="10">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AA958_00955</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH80972">
        <property type="protein sequence ID" value="AKH80972"/>
        <property type="gene ID" value="AA958_00955"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_00955"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.211"/>
    <dbReference type="OrthoDB" id="856767at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002518978" evidence="7">
        <location>
            <begin position="18"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="329"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="371"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="421"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="448"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="504"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="735"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="789"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="829"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="9">
        <location>
            <begin position="17"/>
            <end position="245"/>
        </location>
    </feature>
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        <location>
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            <end position="401"/>
        </location>
    </feature>
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        <location>
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            <end position="708"/>
        </location>
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        <location>
            <begin position="768"/>
            <end position="858"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AKH80972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="866" mass="90904" checksum="645DB4D48D14670D" modified="2015-07-22" version="1">MLKATLRSFFAHKGRLLLSALAVLLSVAFVSGSLIFSDTVSRTFDRLFASTAADVAVSPKEAFEQNRGFGSGLVPTLPASVADEVAKVPGVQAVHLDVEVENLTVTDAENEPIGRSTGPPTIATNWYVSDRSPVELSDGREPAGAGEALLDKDTADRKNIGIGDTLNVLAQPGRFEVEVVGIAKFTTTNPGATVVYLDTAAAQRQLLDNPELRDGEAAGPALATSVSVDAAPGVSDGALKKRVKAALDGNYAVQTADEQAKSAAEELGTFLDIIKYVMLGFAGIAVLVGIFLIVNTFSMLIAQRTRELGLMRALGADRRQVRRSVLTEALLLGLAGSTLGLLSGIGLAVGLIETMGLLGMNLDAAEMVVSWVTPVFAYAVGVGVTFVAAYLPARRAARVSPMAALADLEIAEVGRPMRVRAALGSVLGVAGALSFSLCATADRTRDSAVWLVGGVVLTMLAVVAAGPLLVRPVIRVVGGWFPRIFGSVGALSQRNALRNPRRTGATAVALMVGLALVGGMSVAAASMTKSFDEEIDRTLGADFLVQSDSFGPFPREVTERVEEADGVGLVVRQRFAPLRVTLPDGEKTSTSAGAFDKELDQVSRLEYAQGSTGGALAPGHVGLQRQFARDHGIRMGSTLRVEFPNGKEAELTVGALTKQETSGGFGAAGGFFLGMETLEKYLPGGQEAVVFVNAASGTDVDKLRASLESGLEAFPQVKVRDQADFKELIREQIIVLLYLVFALLGLAIVIAVLGVVNTLALSVVERTREIGMLRAIGLSRRQTRRMIRLESVVIAVFGALLGLVLGLAWGAGVHEVLALEGMRAFAIDWTVQLAVVIGSVLVGLLAALLPALRASRLNVLAAIAHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2B8</accession>
    <name>A0A0F7N2B8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH luxR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_04250</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014888.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_04250"/>
    <dbReference type="EnsemblBacteria" id="AKH81533">
        <property type="protein sequence ID" value="AKH81533"/>
        <property type="gene ID" value="AA958_04250"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_04250"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.891"/>
    <dbReference type="OrthoDB" id="1687028at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA_16"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
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        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
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        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="323"/>
            <end position="389"/>
        </location>
    </feature>
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        <location>
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            <end position="409"/>
        </location>
    </feature>
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        <location>
            <begin position="394"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH81533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="409" mass="43385" checksum="0B9BCB56BFED1D6B" modified="2015-07-22" version="1">MELHGRVYELSVMYGRLHRMRHEQSGLILLNGPKGCGKTVLLDRITDTARRAGFDVVNGRMAHRKKLLLAASFGFLAFSSPDQPDNPASGPDLLEEALGAELPAHGRTAARPVLVALDDVSWGDPHVQAALRGLPAALPTRPVLWLLSGTGGPAPHVPIQHPDAVGLALGPLNGRDALRMAAERLGGAPDELIQRLVAACGGHPALLGAVLDELVADGGCRVCGRVAALVPAMLPPRVVTALLRTDPRLSGPARDLLHAVAARRLPPRMSELLRLPASQAVSTLASAQEATEAGVLVLDGDRLHFRHPLLQQAAELLHYERPAARAGELLSPTEEAVTRLVAAGLTNRQIASRINLSPHTVNFHLRKIFQKLGVSSRVELVGARLHLLDPASDAGHPPPAPESRPAHAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-12-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2H7</accession>
    <name>A0A0F7N2H7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNAse</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_04560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014939.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH81584">
        <property type="protein sequence ID" value="AKH81584"/>
        <property type="gene ID" value="AA958_04560"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_04560"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.961"/>
    <dbReference type="OrthoDB" id="1473648at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007295">
        <property type="entry name" value="DUF402"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035930">
        <property type="entry name" value="FomD-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04167">
        <property type="entry name" value="DUF402"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159234">
        <property type="entry name" value="SSF159234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF402" evidence="1">
        <location>
            <begin position="57"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="170" mass="19158" checksum="53C0B4C33A3E588E" modified="2015-07-22" version="1">MADLVRVIYRKYDGTLHWNSTMRRLGEDEHGVWLGQPAGGTTRKGTGPPVVFECAHVALFPRDAWWTAEFNAPPRRTDLYADITTPPRWRSAAEVTMVDLDLDVARRRGEREPRLLDEDEFADHRVRYGYSEETVARATASAAWLMAAVAAGTEPFAGAYLHWLEQVAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2I8</accession>
    <name>A0A0F7N2I8_9ACTN</name>
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        <recommendedName>
            <fullName evidence="3">Aldose 1-epimerase</fullName>
            <ecNumber evidence="3">5.1.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_08205</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>alpha-D-glucose = beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:10264"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:17925"/>
            <dbReference type="EC" id="5.1.3.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 3">Carbohydrate metabolism; hexose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the aldose epimerase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.3" evidence="3"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015566.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_08205"/>
    <dbReference type="EnsemblBacteria" id="AKH82216">
        <property type="protein sequence ID" value="AKH82216"/>
        <property type="gene ID" value="AA958_08205"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_08205"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1731"/>
    <dbReference type="OrthoDB" id="1512477at2"/>
    <dbReference type="UniPathway" id="UPA00242"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004034">
        <property type="term" value="F:aldose 1-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019318">
        <property type="term" value="P:hexose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015443">
        <property type="entry name" value="Aldose_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005096">
        <property type="entry name" value="GALM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="94"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="195"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="333"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR005096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR005096-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR005096-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR005096-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH82216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="368" mass="38776" checksum="880049A9EE73D93F" modified="2015-07-22" version="1">MAETPLPPPGAVPAPSVTAEPFGKLADGTPVERWTLVAGGTRVRVLSYGGIVQSVEVPDRAGRYANVVLGLATVDEYVEHPDPYFGALIGRYANRIAGASFTLGDRTYPLPANDGPNCLHGGARGFDKRVWAAAAAPAAPGSAALLLSRTSPDGEEGFPGTLDVRATYTVTAEGALRFDYEATTDAPTVVSLTNHSYVNLDGEGSGSIEDHRLRVAASRFTVNSPTSAPTGEIADVAGTPFDFRTARPVGAELRSGHPQLLIGLGYDQNLVLDKGVTATPEPVAEVSSPASGRSLRVLTTEPGLQLYTANFVFPSFTGPSGRAYRPGDGLALETQHFADSPHHPHFPSTVLRPGEHYRSATVYEFAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2I9</accession>
    <name>A0A0F7N2I9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_04635</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014954.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_04635"/>
    <dbReference type="EnsemblBacteria" id="AKH81599">
        <property type="protein sequence ID" value="AKH81599"/>
        <property type="gene ID" value="AA958_04635"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_04635"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.977"/>
    <dbReference type="OrthoDB" id="1502873at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="13"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="392"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="586"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH81599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="692" mass="68780" checksum="8707F55FA7078E1D" modified="2015-07-22" version="1">MKDAATEKFAALLRELKQRSGRSYGSLAARLHVSTSTLHRYCNGDAVPSSYAPAERFARLCGATPEELVELHRRWHRVNGTRRGSAPSWAAGEPPAGSSRGGAEGRPAGARPGARGSGARGAPGAGMSEGEAGRRSRGARPGSGAAAGGGVGDRSGAAAEAARGGATGEVNEAKPPAAGPAANDATATVPSPPGAAQGRGSAAAGAASAARPSASGGADGRDSGAGEAPDSAAPAERPMASGGIAARGADVRAGSGGVRGGAGSAGGGAGDVADSAVQHSVAGGTGVATHGPSAAAPRGDAAREGGAGDASASAPLGSPAREVRGGASDSGSGEIRRLSGKLRPGRDSARGASPSSRDGRGPRWARRWRRVGVPGAGVAAAALVAFVAASSGSTGEGRADGDTGPASGVLADGGRGGGGAQGGESAEKERSAEPSERRKPAPAGGGEGAEADATPGATPRRGGAGTAGKDTPAVRTPLAWSVRSHVWSNGCDHRYLIDKSPDDVPPPPVAQDAEAWASSQGAVHGGTTNIETAIEPRGDEPVTINAVHVRKTSTGAPLPWSAFAMSSGCGGEVTQAAYRVDLDKPRPVLKPRQGGDSTHTWDPPALPFRVTDDEPLSLLIHADTEDYDVGWYLEVEWSSGDESGAVRIDDQGAPFRTSSLKGRPLYDYDTLEGSWYSWPVDAPADESASPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2J0</accession>
    <name>A0A0F7N2J0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_04660</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014958.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_04660"/>
    <dbReference type="EnsemblBacteria" id="AKH81603">
        <property type="protein sequence ID" value="AKH81603"/>
        <property type="gene ID" value="AA958_04660"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_04660"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.982"/>
    <dbReference type="OrthoDB" id="445691at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.101.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015020">
        <property type="entry name" value="DUF1906"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036366">
        <property type="entry name" value="PGBDSf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08924">
        <property type="entry name" value="DUF1906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="SSF47090"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519097" evidence="2">
        <location>
            <begin position="34"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="domain" description="PG_binding_1" evidence="3">
        <location>
            <begin position="455"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="PG_binding_1" evidence="3">
        <location>
            <begin position="527"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH81603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="586" mass="59434" checksum="5EB32DBD880A674B" modified="2015-07-22" version="1">MSPSRTGSWRPLLAGLAALVTLGGLTAAGPAAAASPPGTGRTVDYRGYEVTVPAGWRVVDLAADPGACIRFDRPAVYLGEPGDQSSCPPGLKGRTAGLVVEPIDAGAARQTTAATAVAPRGSATAPAAKSRDGAIQVAVEDAGVLVTAAHGPATEDLVRGVLAGAELTAGAERTELPAAGAASGGAAAPTAAAGPQPGDFRGQGFDACAAPSQTTMDAWLAGSPYRAVGVYISGATRACAQPNLTASWVTNQTNKGWHLIPIDVGRQAPCSNFSNKMSSDPVTARAQGVSAANASVTAAQSLGIPAGSALYSDIEGYTSTASCKAAVMSYVSGWTEGLHAKGYLSGLYSSASSGIRDAASVYDDARYLRVDHLWFAWWNGVADTDAGSYVPDSYWAGHQRIHQYVGEVYETYGGQRLHIDRNYLDVGKGTPPPVTCTTANLSFNAYGTIRSGSTGALVDAAQCLLEAAGHDPGGATPTGTFDAGTVTATKAFQTARGLTADGIIGPRTWTALLARGTTPTLQNGSTGDAVTRLQRALTAALGRTVGIDGIFGSGTQTAVRDYQTSRGLGVDGIVGPATWGALQAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2N7</accession>
    <name>A0A0F7N2N7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SpoOJ or ParA or ParB or repB family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_05000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015014.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_05000"/>
    <dbReference type="EnsemblBacteria" id="AKH81659">
        <property type="protein sequence ID" value="AKH81659"/>
        <property type="gene ID" value="AA958_05000"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_05000"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1051"/>
    <dbReference type="OrthoDB" id="591335at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008323">
        <property type="entry name" value="UCP033563"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36454">
        <property type="entry name" value="PTHR36454"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06245">
        <property type="entry name" value="DUF1015"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033563">
        <property type="entry name" value="UCP033563"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH81659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="423" mass="46165" checksum="B700DB05FAA494A0" modified="2015-07-22" version="1">MQRSPGLDLRPFRGLRYAPSRVRSLAAVTSPPYDVVVRPDGLHHLETADPYNIVRLILPQDGDPATRHRLAADTLHRWRAEGVLVPDPRPALYVYEQRRGDLLQRGVVGLLALSEPADGVVLPHEDVMEEIVADRAGLMRETAANPEPLLLSYRSDGAATGTAAVVARTTARTPLLATTTDDGFAHRLWAVTDQEEIAAVRADLARRQALIADGHHRWATYLRLRAERPAPPGETGPWDYGLVLLVDTARHPLVVRGIHRVLRTLPPAEALRLVGDGARVRRLDAPLPAALRELEGTEGNAFLLAGEDGLHLVERPDQGLLARTVRTDRPAAWRTLDATVLHATLIEHVWRLPDDPEHIGYVHEAAAAAAQAARLGGTAVLMKPVAEDLVRELARDGVMMPRKSTSFGPKPATGLVLRALDLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2W1</accession>
    <name>A0A0F7N2W1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_05540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015103.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_05540"/>
    <dbReference type="EnsemblBacteria" id="AKH81749">
        <property type="protein sequence ID" value="AKH81749"/>
        <property type="gene ID" value="AA958_05540"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_05540"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1161"/>
    <dbReference type="OrthoDB" id="1972181at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="263" mass="28043" checksum="870B318D82D17FF9" modified="2015-07-22" version="1">MRDFTTGFGYVGKGLRWVAGHGRSWALGLVPALIALVLYAAALAALAYWADDIAVWATPFADGWDSPWQGLLRGLFMALLLLGGIGFALLTFTAVALLIGDPFYEALSGRVEEDAGFCPPSPDEPLLPGLWRSLKESVHVLSRALMFTVPLFFLGFVPFLGQTVVPALGFAVAGFFLTVELTSFALQRRGIDVRGRLALLRRRKMLALGFGVPIVLLFLVPLAAVVVMPGAVAGATLLARHLVGDDVRDRGPAPAPGPPPVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2X2</accession>
    <name>A0A0F7N2X2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ricin B lectin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_12875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH82970">
        <property type="protein sequence ID" value="AKH82970"/>
        <property type="gene ID" value="AA958_12875"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_12875"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2709"/>
    <dbReference type="OrthoDB" id="1708804at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="SSF50370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0430">Lectin</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="356" mass="37891" checksum="2DEDFC0D45DF4A77" modified="2015-07-22" version="1">MNKADFTVAGDRPCRHAGVVIHEEGGLPGPRPARPGPARAPRPEQLRTRAEYLAALRELRTWSGLTYRELEAKAGTHADSLPASTIATALGRTTLPRERFVDAFTRACGLAEQDVGPWLEARRRIATREHAPPPPEKDDDREPAPPPAGPAPRWRWAAGLLAAVGIGAGGTLSVQALLPDGSGPGAPRAAVGSLAVPGLDLQAVGSWAEIRPGRSPELCVTEGTDRTGRYRSAVAAQQPCARAALPRVYLEPVGDGAVQIQWHHPEHGIGCLTVMREGPGRDLLEPREACADDDPAQRFRLEAAGEGADRRFRIRPDTGECLAPREEDTGPGAEIARARCSGGAEQEFTISLTAPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2Z0</accession>
    <name>A0A0F7N2Z0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_09080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015703.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH82356">
        <property type="protein sequence ID" value="AKH82356"/>
        <property type="gene ID" value="AA958_09080"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_09080"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1913"/>
    <dbReference type="OrthoDB" id="1869153at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH82356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="199" mass="22308" checksum="AA6B98636698144F" modified="2015-07-22" version="1">MSWIEVDYDDAKWLWVPQQWEGMPWSGPAEWAEAFAEAWWTLADVEPGDEEEVARLRDALLEFATRAGTVFPGQDLYLYLPDPRQAPVPLAVWGLATAGERNDRLRELVRSMDAEAVEAPIVELFRHPHLGNGLRAMRYFTDPGDGTLGCSLNYAFRSEPHGVDVLVRALSSDVGRLAAAAQDMDELALAVRVRRDGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3A6</accession>
    <name>A0A0F7N3A6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_13885</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016473.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_13885"/>
    <dbReference type="EnsemblBacteria" id="AKH83145">
        <property type="protein sequence ID" value="AKH83145"/>
        <property type="gene ID" value="AA958_13885"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_13885"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2922"/>
    <dbReference type="OrthoDB" id="973241at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008335">
        <property type="entry name" value="Mopterin_OxRdtase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000572">
        <property type="entry name" value="OxRdtase_Mopterin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036374">
        <property type="entry name" value="OxRdtase_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00174">
        <property type="entry name" value="Oxidored_molyb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00407">
        <property type="entry name" value="EUMOPTERIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56524">
        <property type="entry name" value="SSF56524"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="Oxidored_molyb" evidence="3">
        <location>
            <begin position="293"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH83145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="429" mass="45454" checksum="2034110633E56C9E" modified="2015-07-22" version="1">MSAVRPPAPRPGPHSGPAAGPGAGPPPPGPFRPAFWRSPLRGPWFTALLGTVLLAGLPLMLLTGFLSYAAYNPDLPGNDTTPGKGLLGFYLFSWPTDPHWLYRLNQGVHVTLGVALVPVLLAKLWSVLPRLFAWPPLRSARHALERGSTLLLVGSALFEFATGILNMQLFYVFPGSFYTLHFYGAWVFLGALAVHLATRVGKLRRGLHDRGMDELRATEPAPPTISRRGAVALVGAGSLGLVAVTAGQSIGGPLRRTALLAPHGGGNPGEGPNGFQINKTAAALGIEPADIGERWRLVVRAGDGRPAVLTRAELLALPQHTAALPIACVEGWSTDDQLWRGVRLADLAALAGAGEGDGVFAESAQQKGAFRAASLRANQVRDPRSLLALHVNGAPLSRDHGYPARIIVPANPGVHNTKWVTRLTFGELP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3J8</accession>
    <name>A0A0F7N3J8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_06745</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015311.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_06745"/>
    <dbReference type="EnsemblBacteria" id="AKH81959">
        <property type="protein sequence ID" value="AKH81959"/>
        <property type="gene ID" value="AA958_06745"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_06745"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1409"/>
    <dbReference type="OrthoDB" id="1691158at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH81959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="160" mass="17718" checksum="F86530DDE8202F98" modified="2015-07-22" version="1">MAEHTRSSITIDAAPDAVMTVIADFDRYPEWTGEVRRTEVLEADGQGRAVRVLLVLDAKTIRDEQTLAYTWAGPHEVRWTLEKSQMLRALDGAYLLRPLAGGERTEVTYELTVDVKIPMLGMMKRKMEKIIIERALDGLKQRVESVPGASADSGSGSGTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3T6</accession>
    <name>A0A0F7N3T6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Anti-anti-sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_15035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016630.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_15035"/>
    <dbReference type="EnsemblBacteria" id="AKH83315">
        <property type="protein sequence ID" value="AKH83315"/>
        <property type="gene ID" value="AA958_15035"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_15035"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3168"/>
    <dbReference type="OrthoDB" id="1864829at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="1">
        <location>
            <begin position="19"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="140" mass="15481" checksum="24C8A3AD27828A25" modified="2015-07-22" version="1">MRAHRLTLNVLSSSAQCAVIRVGGELDHGGERLFLDTVGSCVDSGHRYVVLDLTTLTFCDSRGLNCLFAVRWLLRRQGGELLLAAVGRRVTYLLEQTGSTDVIAMYRSVREALEHVPEPLRARWPPGAVPDAARPSRPDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N406</accession>
    <name>A0A0F7N406_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-methyladenine DNA glycosylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_11455</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016082.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_11455"/>
    <dbReference type="EnsemblBacteria" id="AKH82746">
        <property type="protein sequence ID" value="AKH82746"/>
        <property type="gene ID" value="AA958_11455"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_11455"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2411"/>
    <dbReference type="OrthoDB" id="1781735at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH82746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="312" mass="34120" checksum="A04FB5266745746F" modified="2015-07-22" version="1">MSAAPDHRARTRTWAPPGPYDLWRTLGVLRRGPGDPAFRVADGAVWRASRTPAGPGTLRVAPAGGAVAAEAWGPGAEWLLDGLPALLGAEDDPEPFTPRHRVVHEARRRHPGLRLIRTGVVLESLIPSVLEQKVTTDEAYRSWRLLLHRYGTEAPGPAGTELRMRVMPDARGWAMIPSWEWHRAGVDGKRAATIVRAVRRARALQAAADMDLEAATRRLTALTGIGPWTAAETLQRVIGAADAVTVGDLHLPRIVGYTLAGERNADDERMLELLAPYEAGGQRHRATRYICLLGRMPPRRKPKAAIPDIARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N416</accession>
    <name>A0A0F7N416_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Xaa-Pro aminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_15530</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase M24B family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016697.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_15530"/>
    <dbReference type="EnsemblBacteria" id="AKH83385">
        <property type="protein sequence ID" value="AKH83385"/>
        <property type="gene ID" value="AA958_15530"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_15530"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3269"/>
    <dbReference type="OrthoDB" id="415910at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007865">
        <property type="entry name" value="Aminopep_P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_NTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001131">
        <property type="entry name" value="Peptidase_M24B_aminopep-P_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05195">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01011">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="SSF53092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00491">
        <property type="entry name" value="PROLINE_PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP_N" evidence="7">
        <location>
            <begin position="76"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH83385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="516" mass="56921" checksum="FB86334E56DE7D67" modified="2015-07-22" version="1">MTQEQPQTRTPETAETAEPAETAPGATAEGAEGAEGAEEKPVKQRKNGLYGALSDELAENMKSGWADTERHDLQPLPQAPYAAERRAALSARFPGERLVIPAGNLKVRANDTEYPFRPSSDYAYLTGDRTEDGVLVLEPVTTGDGTPGHEATAYLLPRSDRTNGEFWLSGQGELWVGRRNSLTENEKLLGLPVKDVRKLTEHLAEATGPVRLLRGYDAAVDKALDDKVTGERDEEFRVFLSEMRLVKDEFEIAELEYACESTARGFEDVVKVLDRAEATSERYIEGTFFLRARVEGNDVGYSSICASGPHATTLHWVRNDGPVRSGELLLLDAGVETRNLYTADVTRTLPIDGTYTPLQRRIYDAVYEAQEAGIAAVRPGAAYRDFHDASQRVLAAKLIEWGLLQVEDVDKVLELGLQRRWTLHGTGHMLGIDVHDCAAARTEEYVGGTLRPGMCLTVEPGLYFQADDLTVPDEYRGIGVRIEDDILVTEDGCRNLSAGLPRQADEVEAWMARLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4C2</accession>
    <name>A0A0F7N4C2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_08220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015569.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_08220"/>
    <dbReference type="EnsemblBacteria" id="AKH82219">
        <property type="protein sequence ID" value="AKH82219"/>
        <property type="gene ID" value="AA958_08220"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_08220"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1734"/>
    <dbReference type="OrthoDB" id="1341722at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="345" mass="35836" checksum="F7C02F3004AF660A" modified="2015-07-22" version="1">MPHAPGEPALGRLGFAAPPPDPADTSPYAFPDGGRWRTEIPSVEGPEALAAVLEESTRLGVPVHRISQGSGVWMLTDAEIADMVAACAARDIELSLFTGPRGTWDTGGATRSPSGGGGLRARGHDQLAGCVEDALRAARLGVRCLLVADEGVLWLLHGLREIGELPADTTFKVSALVGPVNPAAYAVWERLGADSLNIPSDLSLQQLTEIRRVSAAPMDLYVEAPDDLGGYVRMYDAAELIRRGAPLYLKFGLSKAPGIYPYGAHMRETVLATARERVRRGRLVLDLLDRLGAGGAMSPPGSRLPGALHRFPGAGSGAAPGTGPGPGPVATPAPASSPASVSEGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4S3</accession>
    <name>A0A0F7N4S3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA small subunit methyltransferase E</fullName>
            <ecNumber evidence="6">2.1.1.193</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_09340</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>S-adenosyl-L-methionine + uridine(1498) in 16S rRNA = H(+) + N(3)-methyluridine(1498) in 16S rRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42920"/>
            <dbReference type="Rhea" id="RHEA-COMP:10283"/>
            <dbReference type="Rhea" id="RHEA-COMP:10284"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74502"/>
            <dbReference type="EC" id="2.1.1.193"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the RNA methyltransferase RsmE family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.193" evidence="6"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015744.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_09340"/>
    <dbReference type="EnsemblBacteria" id="AKH82398">
        <property type="protein sequence ID" value="AKH82398"/>
        <property type="gene ID" value="AA958_09340"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_09340"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1971"/>
    <dbReference type="OrthoDB" id="1490892at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006700">
        <property type="entry name" value="rRNA_ssu_MeTrfase-E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30027">
        <property type="entry name" value="PTHR30027"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04452">
        <property type="entry name" value="Methyltrans_RNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015601">
        <property type="entry name" value="MTase_slr0722"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00046">
        <property type="entry name" value="TIGR00046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR015601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH82398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="249" mass="25668" checksum="9446F9C9058EF573" modified="2015-07-22" version="1">MTAPVFVAEPAVLDAARPGAVLALTGPEGRHAVSVRRLRAGEDVVLTDGAGRGAYGIVAGAEGRDRLLVTCAEVREEPAPRPRLTVVQALPKGDRGELAVETMTETGVDAVVPWAAARCVTRWRAERGKKSLAKWRATAREAGKQARRLRFPEVAGLHATKELLPLLADAAFAAVLHEEGAAPLAAAALPEEGEIVLVVGPEGGVAPEELAAFEGTGAGAYRLGPSVLRTSTAGTAAGAVVLAATGRWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4U5</accession>
    <name>A0A0F7N4U5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_09510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015767.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_09510"/>
    <dbReference type="EnsemblBacteria" id="AKH82423">
        <property type="protein sequence ID" value="AKH82423"/>
        <property type="gene ID" value="AA958_09510"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_09510"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2005"/>
    <dbReference type="OrthoDB" id="1711335at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="161" mass="17230" checksum="C8A6B17A8207E711" modified="2015-07-22" version="1">MTQGRPGALPRGTAQRTLNSVQGTGGGHAGSAEEPGAVADADGPAAGGAHRLWHVTLSVAGPEAPLKEIRRGLERLAHDHPFLLTSRYANDHAEIRYWEEARDLHDAAAVALRLWGEHRASAQLPPWEIVGLEVIARETYHQRIADGYGPAPAVPVGVHPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4W5</accession>
    <name>A0A0F7N4W5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_06095</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015200.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_06095"/>
    <dbReference type="EnsemblBacteria" id="AKH81847">
        <property type="protein sequence ID" value="AKH81847"/>
        <property type="gene ID" value="AA958_06095"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_06095"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1273"/>
    <dbReference type="OrthoDB" id="1100985at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH81847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="305" mass="33676" checksum="5E60313C63E52B03" modified="2015-07-22" version="1">MNSVSEVVHGFPHLRTVRSALTALYRRLTADLLHADFPVSVPPADVALAADEDLHLGVQRVAHTLVQHLRLPDARVIVGFREMPEAAVVELAAGPEYFVELNPRFREHRRDIGGALAHEVMHVYLDRLGLSFPETAENEILTDTATAYLGAGWLLLDAFREGGGASQRFGYLTPEEFGYVVAKRALAFGENPEVWFTSPQAYEAYTAGMDLARRDAARPPLAASGRLGRHRYTRDRRRAQELFLRAADGGLTTTAAPVDGYAFEAGPPMRVSFPCPVCHQRIRVPVRGYVRARCGLCKAVLECDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4Y1</accession>
    <name>A0A0F7N4Y1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_06170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015215.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_06170"/>
    <dbReference type="EnsemblBacteria" id="AKH81862">
        <property type="protein sequence ID" value="AKH81862"/>
        <property type="gene ID" value="AA958_06170"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_06170"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1289"/>
    <dbReference type="OrthoDB" id="2092752at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="74" mass="7783" checksum="A7EB8A92894F4DA8" modified="2015-07-22" version="1">MAENHDHGHTPAAWTAVVIIFIGFCVSGALMVMDQPLLFWLSLAIIPIGGVVGAVMRGMGMGKKPLPPVRTAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5B7</accession>
    <name>A0A0F7N5B7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidoglycan glycosyltransferase</fullName>
            <ecNumber evidence="1">2.4.1.129</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AA958_10655</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23708"/>
            <dbReference type="Rhea" id="RHEA-COMP:9602"/>
            <dbReference type="Rhea" id="RHEA-COMP:9603"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:78435"/>
            <dbReference type="EC" id="2.4.1.129"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.4.1.129" evidence="1"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_10655"/>
    <dbReference type="EnsemblBacteria" id="AKH82608">
        <property type="protein sequence ID" value="AKH82608"/>
        <property type="gene ID" value="AA958_10655"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_10655"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2241"/>
    <dbReference type="OrthoDB" id="652304at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008955">
        <property type="term" value="F:peptidoglycan glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3810.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001264">
        <property type="entry name" value="Glyco_trans_51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036950">
        <property type="entry name" value="PBP_transglycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00912">
        <property type="entry name" value="Transgly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="52"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Transgly" evidence="11">
        <location>
            <begin position="105"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="10">
        <location>
            <begin position="379"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="591"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="692"/>
            <end position="761"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AKH82608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="761" mass="81555" checksum="919D51467EFB6FD7" modified="2015-07-22" version="1">MSHTEMRQGTRSFGPQAEPEDTERTDLEPAPPPAPPAGRPAKERRRRTYRRTWWKVLLGAAMLTVALASGAFAVGYLTVDIPRPNDMATAQSNHYFYADGTKLADKGEVDRESVELQRVPDHVRMAVLAAEDREFYSDSAVNPMAMVRAGFNTLTGKGTQSGSTITQQYVKNYYLDQEQTISRKLREAFIAIKLDREVTKDDVLEGYLNTSYFGRNAYGVQAAAQAYYDKDVEELTVAEGAFLATLLQAPSTYDVAVHPGNRPAAEARWNYVLDGMVKEGWLAPGSRGSLEFPVPEPSRLDPGLSGQRGYLVEAINGYLTEHRIIDEKTLAAGGFRIVTTLQPEKQDAFVGAVEEQLTYQLDPESNPADAYVRVGGASIDVASGKVVALYGGTDYTQQYVSNATRRDYQAGSTFKPFVFAAAVQEKAENWEGKPITPRTMYDGDTARRVIGKKGKALRYAPSNQDDVSYGRLNVADATNDSVNSVYAQMAQDVGPRKVRATAVRLGLPSATPELKAHPSIGLGTATPSALDLAQAYATLAGHGDHGGYRLVDELSRNGEIFQLPPRRPHPVISRNAADATTAMLQNVVENGSGEEAQSAERPAAGKTGTGEHDRSAWFAGYTPELATVVGVMGQDPETGAQKSLHGVLGEDRISGGGVPAKIWGAYTRDALWDVPASDFDLEVSHRQRMPYVPPPAPDPAEVPMPAPAAFPAPPVPAAPPVPAPPVPAAPPVPAPPVPAPPVPAAPPVPAAPAGAAPPVPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5M3</accession>
    <name>A0A0F7N5M3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_18595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017177.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH83880">
        <property type="protein sequence ID" value="AKH83880"/>
        <property type="gene ID" value="AA958_18595"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_18595"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3901"/>
    <dbReference type="OrthoDB" id="1865374at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="63"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="225" mass="24244" checksum="1F5B72B9241240AA" modified="2015-07-22" version="1">MRADTPRIDRPADLDAVRTSYDHVADNYVQLMRTTGMGDIRRYPWLKAAVDVFADAVGDSGPVLDVGCGPGQVTAYLAERGLDASGVDLSPGMIENARRLHPQCRFSVSSATDLELADGSLGGVLGWWSLFNLPRDVLPQVLGLFARALKPGGHFLTGTHVGEGDLVRTEAYGKEGVRWTTHRWRPEEFVAVIEGAGLRPVAELRLPADGQTGPGVVVMAKKPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5R0</accession>
    <name>A0A0F7N5R0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AA958_11495</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GtrA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016089.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_11495"/>
    <dbReference type="EnsemblBacteria" id="AKH82753">
        <property type="protein sequence ID" value="AKH82753"/>
        <property type="gene ID" value="AA958_11495"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_11495"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2419"/>
    <dbReference type="OrthoDB" id="1813832at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007267">
        <property type="entry name" value="GtrA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04138">
        <property type="entry name" value="GtrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="GtrA" evidence="8">
        <location>
            <begin position="4"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="136"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH82753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="183" mass="20178" checksum="D454F190C8DA26C6" modified="2015-07-22" version="1">MAEFAAVGGIGVLVNLAVFNLVRNSTELPVVRCSMIATAVAIIFNYIGFRYFTYRDRDKTRPPREFTLFLVFSTAGLVIENGLLYVATYGFDWDTPLQNNIFKFLGIGMASLFRFWSYRSWVFRAVPAAARPAAAPADGGEAGDIAVAPGVPIPGSRRKPREAKEPEEPEEPEAQEEAVAARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5U6</accession>
    <name>A0A0F7N5U6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptide ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_11620</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016110.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_11620"/>
    <dbReference type="EnsemblBacteria" id="AKH82774">
        <property type="protein sequence ID" value="AKH82774"/>
        <property type="gene ID" value="AA958_11620"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_11620"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2444"/>
    <dbReference type="OrthoDB" id="1181903at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="24"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="242"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="57"/>
            <end position="64"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH82774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="272" mass="28871" checksum="3F47F8AF9422184D" modified="2015-07-22" version="1">MTTTIPGASGPGTAYARVAAAGATELTKVYGEGETKVVALDRVSVEFMQGEFTAIMGPSGSGKSTLMHCMAGLDTISGGSSRIGETELNGLKDKKLTQLRRDKVGFVFQAFNLLPTLNALENITLPMDIAGRKPDEQWLRQVVETVGLSGRLKHRPSQLSGGQQQRVAVARALAARPEIIFADEPTGNLDSRSGAEVLGFLRNSVRELGQTVVMVTHDPVAAGYADRVVFLADGRIVDELRDPTSEQVLDKMRSLPGGAAPQTPQASTPRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N656</accession>
    <name>A0A0F7N656_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">APH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_08850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
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            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015664.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_08850"/>
    <dbReference type="EnsemblBacteria" id="AKH82317">
        <property type="protein sequence ID" value="AKH82317"/>
        <property type="gene ID" value="AA958_08850"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_08850"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1864"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd05154">
        <property type="entry name" value="ACAD10_11_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041726">
        <property type="entry name" value="ACAD10_11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="52"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="356" mass="38736" checksum="7B5A65F414FC99D2" modified="2015-07-22" version="1">MPEPPQRDIETTRRSLARWLAGRLPEAGTPEVGVEAPRGRGFGPETLWAVAAWQRTGTRRDFAVRVASTRYQVLPESRLVDEYRVLRALAPTPVPVPAVLGYEADPAVLGAPFYVTERVRGWTPAERSPYRAGGALADRDEAGRAELWWAGLGVLRTLHGLDADRLNVAFLEHATGAPSSLGGQLDFYERHLDHFAADRSGVVLAALDWLRENLPEPAGPPRLLWGDARLGNIVFRGARPAAVLGWETALLGPPEADLAWFLHVGRHLAGDGPRLAGLPGRQATIDRYEEWLGRPIAGQLPWHEVFAGFRFALVAARTGRLLAEQGLADGASEVPFTRAAERLLAAILAPLDTVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N663</accession>
    <name>A0A0F7N663_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SseB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_16595</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016866.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_16595"/>
    <dbReference type="EnsemblBacteria" id="AKH83561">
        <property type="protein sequence ID" value="AKH83561"/>
        <property type="gene ID" value="AA958_16595"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_16595"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3492"/>
    <dbReference type="OrthoDB" id="1607221at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009839">
        <property type="entry name" value="SseB_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07179">
        <property type="entry name" value="SseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SseB" evidence="2">
        <location>
            <begin position="95"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH83561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="171" mass="18569" checksum="136A72063A0B218B" modified="2015-07-22" version="1">MYGYDQSAGYGAPPGHPQAPPQGHQYAAPPGPYDQPAPGYAEQPLYPEPSQPAPPSLADAVKAFTGGAIGSEDFQQIFATSKIYCPRGDNPGFLALHNTQQPVIPLFSSLKELRRYAGRESKYFTVTGAEVIDLLPTGYGFVLDIEGDHRMVVDAKAVEEMVDFAMRRMYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6A9</accession>
    <name>A0A0F7N6A9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_08990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015689.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH82342">
        <property type="protein sequence ID" value="AKH82342"/>
        <property type="gene ID" value="AA958_08990"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_08990"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1895"/>
    <dbReference type="OrthoDB" id="1771936at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH82342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="145" mass="15914" checksum="5602F7F50DC79749" modified="2015-07-22" version="1">MGSEQTGTGRVTVFPLTHHWPDRRCLLAYTTTGDFGTTAIVGVLPVPELEHPELLAVAAAHHAQGLYGSRRGHENACAGWVICTGWSARIGGSGPRLDVQHTAWSLHLDRRIPLAEQMYGHDVLHTGTFTLNDDELMQQALQLIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6B6</accession>
    <name>A0A0F7N6B6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_12745</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016283.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH82948">
        <property type="protein sequence ID" value="AKH82948"/>
        <property type="gene ID" value="AA958_12745"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_12745"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2678"/>
    <dbReference type="OrthoDB" id="1850770at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="PTHR11803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="SSF55298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH82948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="147" mass="15123" checksum="5175536C62887A7B" modified="2015-07-22" version="1">MTRTLHNPPQLHDPTGYGYSHVATAPGRPVFIAGQYASDETGAVVSADFATQVERSFANLRTALAAAGLGVEDVVRLGTYVVGHDRERLETVLAALHRVWGGSPPAQTLVGVASLALPEMLFEVDAVAVRAVPAAGTGAPGAAAGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6B9</accession>
    <name>A0A0F7N6B9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Prenyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ubiA</name>
        <name evidence="5" type="ORF">AA958_20455</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017454.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_20455"/>
    <dbReference type="EnsemblBacteria" id="AKH84165">
        <property type="protein sequence ID" value="AKH84165"/>
        <property type="gene ID" value="AA958_20455"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_20455"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4311"/>
    <dbReference type="OrthoDB" id="1472516at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13959">
        <property type="entry name" value="PT_UbiA_COQ2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006371">
        <property type="entry name" value="HB_polyprenyl-transferase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039653">
        <property type="entry name" value="Prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048">
        <property type="entry name" value="PTHR11048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01475">
        <property type="entry name" value="ubiA_other"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="154"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="217"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH84165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="306" mass="32210" checksum="5DCC96E23EDF1456" modified="2015-07-22" version="1">MTAAGSVVGPGPARSGSGVRAFLRLVMIEHSIFALPFAYIAALTAMLVDGDGAIEWGTLLLVTVAMVALRTFAMAANRIIDREIDGRNPRTAHRELVTGAVSVRSAWTGALIALAIFLGAAALLNPLCLVLAPVAAVPMVVYPYGKRFTTYPHAILGLAQAIGPIGAWLAVTGEWSWPAVLLGLAVGVWIGGFDLIYACQDVDTDRAQGIRSVPARFGIAGALYGARAAHVVTMALFVWYALATDAGAPFWAGLAVVAGVFAYEHSIVRPDDLSRLNRAFFTLNGVIGIVLFCCAAADLFVRDLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6C9</accession>
    <name>A0A0F7N6C9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_09165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015713.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_09165"/>
    <dbReference type="EnsemblBacteria" id="AKH82367">
        <property type="protein sequence ID" value="AKH82367"/>
        <property type="gene ID" value="AA958_09165"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_09165"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1933"/>
    <dbReference type="OrthoDB" id="1054546at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="19"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="349" mass="36477" checksum="F416A8AE19B77C31" modified="2015-07-22" version="1">MTSIPTRTLGTTGPRVSALGLGCMGMSALYGPVDRKESIATIHAALDAGVTLLDTGDFYGMGHNELLIRDALAARPGSRDQAVVSVKFGALRDPAGGFLGYDGRPAAVKNFAAYSLQRLGTDHIDVYRLARLDPDVPVEETVGAVQELIDAGYVRHIGLSEVGAETVRRAAATAPVADLQIEYSLISRGIEDEILPACRELGVSVTAYGVLSRGLISGHMTRESVRGLGAQDFRAHSPRFAAENIDRNLALVDALRRVADGKGVTVAQIAIAWVLGRGEDIVPLVGARRRDRLAESLGALDVVLDAADLAAIEEAVPPGAAAGERYAPEQMAMLDSERTGGGSGGTAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6K3</accession>
    <name>A0A0F7N6K3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Elongation factor G</fullName>
            <shortName evidence="6">EF-G</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">fusA</name>
        <name evidence="8" type="ORF">AA958_21080</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017551.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_21080"/>
    <dbReference type="EnsemblBacteria" id="AKH84270">
        <property type="protein sequence ID" value="AKH84270"/>
        <property type="gene ID" value="AA958_21080"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_21080"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4439"/>
    <dbReference type="OrthoDB" id="88967at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16262">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01434">
        <property type="entry name" value="EFG_mtEFG1_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03713">
        <property type="entry name" value="EFG_mtEFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00054_B">
        <property type="entry name" value="EF_G_EF_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009022">
        <property type="entry name" value="EFG_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035649">
        <property type="entry name" value="EFG_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004540">
        <property type="entry name" value="Transl_elong_EFG/EF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00484">
        <property type="entry name" value="EF-G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6 8" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="5 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="7">
        <location>
            <begin position="9"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="18"/>
            <end position="25"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="86"/>
            <end position="90"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="140"/>
            <end position="143"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH84270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="706" mass="77472" checksum="7095374CF9CDFD6C" modified="2015-07-22" version="1">MATTSLDLAKVRNIGIMAHIDAGKTTTTERILYYTGVSYKIGEVHDGAATMDWMAQEQERGITITSAATTCHWPLDEVDHTINIIDTPGHVDFTVEVERSLRVLDGAVTVFDGVAGVEPQSETVWRQADRYGVPRICFVNKLDRTGAEFHRCVDMITDRLGATPLVMQLPIGTEADFKGVVDLVRMKAFVWSPEAKLGEAYDVVDIPETHLEAADEWRGKLLEAVAENDEEMMELYLEGEEPTEEQLHAAVRRITINSGKGEGTTVTPVFCGTAFKNKGVQPLLDAIVRYLPSPLDVEAIEGHAVGDPDEVIVRRPSEEEPLSALAFKIASDPHLGKLTFIRVYSGRLNAGSQVQNSVKGRKERIGKIYRMHANKREEIDSVGAGDIVAVMGLKQTTTGETLSDPANPVILESMDFPAPVIEVAIEPKSKGDQEKLGVAIQRLAEEDPSFRVKTDEETGQTIISGMGELHLDVLVDRMKREFKVEANVGKPQVAYRETVRRPVAKHEYTHKKQTGGSGQFARVIIALEPLEGDGYEFVNEVTGGRIPKEYIPSVDAGSQEAMEFGILAGYPLTGVRVRLLDGAYHEVDSSEMAFKIAGSMAFKEAARKAAPVLLEPMMKVEVTTPEDYMGDVIGDINSRRGQIQSMEDRSGAKLVTGLVPLSEMFGYVGDLRSKTSGRASYSMQFDSYAEVPRNVAEEIIAKAKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6M9</accession>
    <name>A0A0F7N6M9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_13355</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_13355"/>
    <dbReference type="EnsemblBacteria" id="AKH83053">
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        <property type="gene ID" value="AA958_13355"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_13355"/>
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    <dbReference type="OrthoDB" id="1688736at2"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
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    </dbReference>
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        <property type="entry name" value="MetI-like"/>
    </dbReference>
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        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
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        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
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        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
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            <end position="132"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="4">
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            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
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            <end position="235"/>
        </location>
    </feature>
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            <end position="295"/>
        </location>
    </feature>
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            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH83053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="300" mass="32399" checksum="6F64B2958F418725" modified="2015-07-22" version="1">MKSLTAGYGRRAPGEPRAVGYLYVLPALVIYALFLLVPFGQSVWLSFLHWDGLTRATSAGFSNYSDIFTDPSLRAPFGHALVLLIFYSLLPVCIGLLLAAAMSRIRIRGMTFFRTVLFLPQVLAMVVVGVAWQSILAPDGLLNDVLRAVGLDSLARPWLGDYDWALPAVGIVGTWVMTGLCLVLFLAGAQRIPKELYEAARLDGAGAFREFFAVTLPALRAEIAVALTLTIVAGLRNFDLIYVMTSGGPGEATSVPAYEVYHRAFELNQVGSAAAVGVALTVLIFTLTVTVSRLVEGRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6X7</accession>
    <name>A0A0F7N6X7_9ACTN</name>
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        </submittedName>
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    </gene>
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        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="AA958_10530"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_10530"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2218"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="119" mass="11405" checksum="C2B4ADA41F01D764" modified="2015-07-22" version="1">MTASPGPWQSAGGSPGRHSSQESRAGSRAAVPGAAKRSVRSRTAAAGPLPAPCVHSSSSTRRPGSAGKLTTSNAPPHGSTAGAAGRCDQSACTLRGKGLAEASQSAPAGVTSLAGASDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-08-12" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7B7</accession>
    <name>A0A0F7N7B7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_11410</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LytR/CpsA/Psr (LCP) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016073.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH82737">
        <property type="protein sequence ID" value="AKH82737"/>
        <property type="gene ID" value="AA958_11410"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_11410"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2401"/>
    <dbReference type="OrthoDB" id="491753at2"/>
    <dbReference type="Proteomes" id="UP000034283">
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    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004474">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00350">
        <property type="entry name" value="lytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
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    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
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        <location>
            <begin position="143"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH82737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="389" mass="42134" checksum="9129E146B67AC8CE" modified="2015-07-22" version="1">MPVVGGGGVPPQRSRGYDDGHGAYGDGYNEGQVYRSGGGDPSGPYDDDGGGRQAGGYGKPPPNWRKRIKIGAIVALVILIVVPVVTYFWADSKLRREVDLSKVEDRPGDQDGTNYLIVGSDSREGMSKERQQELHTGSVEGKRTDSMMILHTGDNGNTMVSLPRDWMVTIPSFTGSETGNRIPEQTQKINAAYAIEGPELLVRTVEYNTGLKIDHYAEIGFGGFANIVDELGGVEMCFDEAVKDKNSGADFEKGCQDLDGAEALAFVRNRYALPGGDLDRTKNQQKLLSKLASESAKFTTIMNPFKLYPTMGAGLDSLIVDKDMSLFNVAQMFWAMKGVSGGDGKSMNLPVVSGGTDPRLGSVQKWDEPKAKQLFEQLKNDDKVTVSAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7L0</accession>
    <name>A0A0F7N7L0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MerR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_23055</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017857.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH84600">
        <property type="protein sequence ID" value="AKH84600"/>
        <property type="gene ID" value="AA958_23055"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_23055"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4859"/>
    <dbReference type="OrthoDB" id="1467120at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036244">
        <property type="entry name" value="TipA-like_antibiotic-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012925">
        <property type="entry name" value="TipAS_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07739">
        <property type="entry name" value="TipAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89082">
        <property type="entry name" value="SSF89082"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0010">Activator</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH merR-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="79"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH84600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="253" mass="28548" checksum="E97FC4304FBCD151" modified="2015-07-22" version="1">MEWSIQEIARTAGTTSRTLRHYGDVGLLRPSRVAANGYRYYDEQALVRLQRILLLRELGLGLPAIAEVLDAGGGPGDTAAALATHLELLEQERRRLGRQIASVKTTLRKLTEGEPLMAEEVLDGFDHTRYEEEVTRRWGKAAYERSDRWWRALSEEEKSDFQRRQQNIARDFAAAHTAGETPDGARAQEIARRQFEWISAGWQGQGPSAEAFAGLGQMYVDDPRFGAHYDAHGEGTAVFVRDAMRVYAERELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7S1</accession>
    <name>A0A0F7N7S1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AA958_16100</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glycosyltransferase 87 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016787.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_16100"/>
    <dbReference type="EnsemblBacteria" id="AKH83478">
        <property type="protein sequence ID" value="AKH83478"/>
        <property type="gene ID" value="AA958_16100"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_16100"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3393"/>
    <dbReference type="OrthoDB" id="1529783at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018584">
        <property type="entry name" value="GT87"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016570">
        <property type="entry name" value="UCP010361"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09594">
        <property type="entry name" value="GT87"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010361">
        <property type="entry name" value="UCP010361"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="192"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="228"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="350"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="485"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH83478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="533" mass="57210" checksum="21A71CC9EDFE99C3" modified="2015-07-22" version="1">MTSVDHDPARRPAAAPAPDEPPVPPTRHDEIAARGSEVLGGPLGRRALLGGSWWTPVRVIALVAIGMFALGMVQKYPCYDGAWFSGANAQYTRACYSDIPHLYQGRGFADDLTPYFDRIPPEASGGMEFLEYPVLTGLFMEVASWLTPGGDDLVHREQVYWLVNAGMLMICVAIVAVCVARTHRRRPWDALLVALAPALALTATINWDLLAVALTAAAMLAWSRSRPVAAGVLLGLATAAKLYPVLLLWPLLLLCLRAGRLRQFATATAAAAGAWLVVNLPVMIRAPDGWAKFYTFSQERGVDFGSFWLIISQRSGEPLDDANIYAAALMVLGCLGIGALALAAPRRPRFAQLAFLIVALFIVTNKVYSPQYVLWLIPLAALARPRWRDFLIWQGCEVGYYMGIWLYLAYTNGGEDAKGLPPDGYHVAIAAHLLGTLYLCAVVVRDIVMPDRDPVRRLGDDDPGGGVLDRARDVRVLAEAGHGRHAAGVHGGPGFGGGPGAPGAPGAGGAPGTMRVRWGVERSAQAGRVSPVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7S2</accession>
    <name>A0A0F7N7S2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_12035</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016177.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_12035"/>
    <dbReference type="EnsemblBacteria" id="AKH82842">
        <property type="protein sequence ID" value="AKH82842"/>
        <property type="gene ID" value="AA958_12035"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_12035"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2532"/>
    <dbReference type="OrthoDB" id="1437290at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045823">
        <property type="entry name" value="TetR_C_32"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19344">
        <property type="entry name" value="TetR_C_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="31"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH82842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="227" mass="24740" checksum="514E8A90EE9D893D" modified="2015-07-22" version="1">MATGGKSSTGNSGDGGEGKPPRRTRRRMTGKERREQLVDVGRMLFAARGFEATSVEEIAAKAGVSKPVVYEHFGGKEGLYAVVVDRETRQLLDMVAGALTAGHPRELLEQAAFALLDYIDEYTDGFRIMVRDSPVAQSHGSFASLISDIATQVEDILGLEFKSRGFDPKLAPLYAQALVGMVALTGQWWLDVRKPKKAEVAAHLVNLAWHGLGDLEAKPRLIGHRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8B4</accession>
    <name>A0A0F7N8B4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_21145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RutC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017560.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_21145"/>
    <dbReference type="EnsemblBacteria" id="AKH84281">
        <property type="protein sequence ID" value="AKH84281"/>
        <property type="gene ID" value="AA958_21145"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_21145"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4453"/>
    <dbReference type="OrthoDB" id="1850770at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006056">
        <property type="entry name" value="RidA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="PTHR11803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="SSF55298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00004">
        <property type="entry name" value="TIGR00004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="135" mass="14732" checksum="7743A3382FB51320" modified="2015-07-22" version="1">MNDTQHTPAKRVIHTPNAVLPVGPFPQAVQAGDFLFISGTVPYDSAREEVVEGGIEEQTAHVMGSIKAILEAAGGTLDDLVKVTIHMKDVDDWARMNAVYETYFDDYLPARMTMQSPPPLGFLVDIDAIAHLPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8F8</accession>
    <name>A0A0F7N8F8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA pseudouridine synthase A</fullName>
            <ecNumber evidence="4">5.4.99.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">tRNA pseudouridine(38-40) synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">tRNA pseudouridylate synthase I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">tRNA-uridine isomerase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">truA</name>
        <name evidence="9" type="ORF">AA958_21325</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 7">
            <text>uridine(38/39/40) in tRNA = pseudouridine(38/39/40) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:22376"/>
            <dbReference type="Rhea" id="RHEA-COMP:10085"/>
            <dbReference type="Rhea" id="RHEA-COMP:10087"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="EC" id="5.4.99.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 7">Belongs to the tRNA pseudouridine synthase TruA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.12" evidence="4"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017580.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_21325"/>
    <dbReference type="EnsemblBacteria" id="AKH84316">
        <property type="protein sequence ID" value="AKH84316"/>
        <property type="gene ID" value="AA958_21325"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_21325"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4490"/>
    <dbReference type="OrthoDB" id="1075262at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106029">
        <property type="term" value="F:tRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02570">
        <property type="entry name" value="PseudoU_synth_EcTruA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00171">
        <property type="entry name" value="TruA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001406">
        <property type="entry name" value="PsdUridine_synth_TruA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020097">
        <property type="entry name" value="PsdUridine_synth_TruA_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020095">
        <property type="entry name" value="PsdUridine_synth_TruA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142">
        <property type="entry name" value="PTHR11142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01416">
        <property type="entry name" value="PseudoU_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001430">
        <property type="entry name" value="tRNA_psdUrid_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00071">
        <property type="entry name" value="hisT_truA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="PseudoU_synth_1" evidence="8">
        <location>
            <begin position="161"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4 5">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4 6">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001430-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001430-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH84316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="284" mass="31293" checksum="85DB84EB66564E42" modified="2015-07-22" version="1">MSDEVAAGCVRVRLDLSYDGSGFSGWARQREGQRTVQEELETALRVVLRAPAPYELTVAGRTDAGVHARGQVAHVDLPEPVWAAQGERGELLLRRLAGRLPHDVRVWRVTAAPPHFNARFSAIWRRYAYRVGDDPGGVDPLLRGHVLWHNRPLDAAAMNAAAELLLGEHDFAAFCKRREGATTIRRLLDLRWSRRADGVLEATVKADAFCHNMVRALVGAMLFVGDGHREPEWVGRVLGAAVRDSAVQVVRPHGLTLEEVGYPADEALAARNTASRRLRTLGAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8N6</accession>
    <name>A0A0F7N8N6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_13610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016427.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_13610"/>
    <dbReference type="EnsemblBacteria" id="AKH83097">
        <property type="protein sequence ID" value="AKH83097"/>
        <property type="gene ID" value="AA958_13610"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_13610"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2864"/>
    <dbReference type="OrthoDB" id="721431at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="52"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH83097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="349" mass="35469" checksum="6E9B64562244A01F" modified="2015-07-22" version="1">MSSTSAASSGRRDAAPGSAAPVPPVSRTALLRAADGVPIEAAYAPGPGAGAPAIVVAHGFTGALERPAIRRAAAVFAQRAGVVTFSFRGHGGSGGRSTVGDREVLDLAAAVAWARALGHARVATVGFSMGGSVVLRHGALYRPEARGDEWEREGRTGAYGNAAAGAGGGARGPATHGAGPDGPVALGSGAEGSVALGADALGAGAIPAGTVPYADAVVSVSAPARWYYRGTAPMRRLHWIVERRTGRAVSRLALKTRIHHRRWNPVPLSPTAAVPRIAPAPLLIVHGTRDGYFPLDHPEALAAAAAPGTAELWLEEDFAHAENAASEDLLERIAAWAAEAAGRRPSRGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8Y7</accession>
    <name>A0A0F7N8Y7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TM2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_14290</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_14290"/>
    <dbReference type="EnsemblBacteria" id="AKH83207">
        <property type="protein sequence ID" value="AKH83207"/>
        <property type="gene ID" value="AA958_14290"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_14290"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3008"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007829">
        <property type="entry name" value="TM2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05154">
        <property type="entry name" value="TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="TM2" evidence="7">
        <location>
            <begin position="91"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH83207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="157" mass="16490" checksum="7195579723AE61BB" modified="2015-07-22" version="1">MSDPYQNPYGQQPGQPGQPGQPGQQPQPGYGYPQYGQQDPNQNPYAQPGQQPGYGYPGGQPGGLPQAPAAAAGYDPNAPYGYDPHGRPYSDKSKIVAGVLQLFIGTLGIGRFYTGHTGMAIAQLLTCGGVGIWALIDGIMILVSDDKTDAKGRVLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N972</accession>
    <name>A0A0F7N972_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4440 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_22890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
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                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">CNQ-509</strain>
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            <dbReference type="EMBL" id="AKH84576.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
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    </evidence>
    <sequence length="126" mass="14021" checksum="407E8902DD8C3652" modified="2015-07-22" version="1">MPNDDHTESLRAAERRLQAAQLASDVAALGELLDDAGRFTGPDGRLYSKDDDLDAHRTGHQVLTGLEEEDLRVFATAHTGVTWFLGTLEGSVGEQPLRARMRYTRTWTRDRAGWKIIAAHATFVTE</sequence>
</entry>
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                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5 6">CNQ-509</strain>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
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    </evidence>
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</entry>
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                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">CNQ-509</strain>
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    </dbReference>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="101" mass="11546" checksum="CD27E79C18BB8194" modified="2015-07-22" version="1">MSVRMFRAKIKEDKVETAEKAAKELFAAIEEAKPEGVRYSWCKLADGRTLVLVVDLEDDEKNPLLTMPAFQETMNGLKNEWISEPLSVEPMTSLGSYRLFY</sequence>
</entry>
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    <accession>A0A0F7N9Z3</accession>
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            <authorList>
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
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    </reference>
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    </evidence>
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    </evidence>
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</entry>
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                <person name="Leipoldt F."/>
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                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">CNQ-509</strain>
        </source>
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    </feature>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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    </evidence>
    <sequence length="278" mass="29628" checksum="BE6D7D4D2308D1D3" modified="2015-07-22" version="1">MRVGLISFGAREFATLHEVCVEGGHTPVVYAYSRSMRPRSATDPAAADTAGRIAAALPAGIDLLLPGSSEGLGTALGGYGLDLLVCFGFSWRLPPAVLSVPRYGVVNVHCSMLPEYRGPAPVLWAIRNGDPKLGVTAHRMNEEFDAGPVLAQERTVPIPDDATPEALWPRLAESLRRVLAVALERAADPSAGEPQSDRGATYAGLMEEEFSVIDTARTAHEVHNQVRTHRYIGPGRGPVAIVGGQRMKVLRTSLTHADGPRLDCADGPLWIAESAPAE</sequence>
</entry>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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    </dbReference>
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        <property type="gene ID" value="AA958_17090"/>
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    <dbReference type="KEGG" id="strc:AA958_17090"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0003700">
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
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        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
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        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="169"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH83642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="269" mass="28828" checksum="70285E9531AE5574" modified="2015-07-22" version="1">MVVNVHSIPARRQAEPCESVVRTPPPRLGPYVIGCSAFRAGGGAPVRHRLLPVNATVLVIDVTGADRLVTGARSAYGIHTTQRWREGVTVGLTPVGTAALLGVPAREFVGETVELADVLGRRREEELAERLAEAGPRRLDVLVATMEAWLTAGPGSPAATPFAAAWHRLQRPGRRIPIPALAARLGVSRRYLELGFRREIGMPPGRVARIARLQHAVGRLADPAHDLAAIAATCGYADQPHFTRDVRELTGLTPTALCANLQYREPAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAG5</accession>
    <name>A0A0F7NAG5_9ACTN</name>
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        <submittedName>
            <fullName evidence="8">Phage-shock protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_22100</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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        </subcellularLocation>
    </comment>
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_22100"/>
    <dbReference type="EnsemblBacteria" id="AKH84439">
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    </dbReference>
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    <dbReference type="PATRIC" id="fig|444103.5.peg.4655"/>
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    <dbReference type="Proteomes" id="UP000034283">
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007168">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="PspC" evidence="7">
        <location>
            <begin position="5"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH84439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="67" mass="7543" checksum="2A72F8A084FA696B" modified="2015-07-22" version="1">MAMPMRPRDGRMIAGVCAGLARRFDTTPTTVRVVFLVSCLLPGPQFLLYLALWVLMPSEEKVQHPAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAG6</accession>
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            <fullName evidence="1">Uncharacterized protein</fullName>
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    <organism evidence="1 2">
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        <lineage>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH85056">
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        <property type="gene ID" value="AA958_25740"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="1938271at2"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH85056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="70" mass="7692" checksum="94FE0A1C04871EA3" modified="2015-07-22" version="1">MDPDGQLALYEAVAAGLKEAHRQVREVAATDAERAELTRRLLAITGAAKHDLAGAARRLERLRRELDARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAR8</accession>
    <name>A0A0F7NAR8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_22965</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_22965"/>
    <dbReference type="EnsemblBacteria" id="AKH84588">
        <property type="protein sequence ID" value="AKH84588"/>
        <property type="gene ID" value="AA958_22965"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_22965"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4838"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH84588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="77" mass="7843" checksum="E07DEF0A29B0BA29" modified="2015-07-22" version="1">MDSGPPAAAAARGPSLSPAFACSLRSAAGAYQEGGRLVAHPDVAMVTIISSLPVWPWMDVTAYALAVHPVDPKAAEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAU4</accession>
    <name>A0A0F7NAU4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_23240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017889.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH84633">
        <property type="protein sequence ID" value="AKH84633"/>
        <property type="gene ID" value="AA958_23240"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_23240"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4899"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519319" evidence="2">
        <location>
            <begin position="30"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH84633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="122" mass="11736" checksum="842C89D81D97E8D8" modified="2015-07-22" version="1">MSHPLKRHLARVALVVAAGAAPVVGAAGAAGAVELPSTNGLNPVSALETGSLPATASQTGSEVLTTGTETANQLGENAGPTTEKALGAVQDTTGKTVEQGQGAVGDTAANLTPELPTSGLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NB47</accession>
    <name>A0A0F7NB47_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metal-dependent hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_23500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017934.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_23500"/>
    <dbReference type="EnsemblBacteria" id="AKH84679">
        <property type="protein sequence ID" value="AKH84679"/>
        <property type="gene ID" value="AA958_23500"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_23500"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4955"/>
    <dbReference type="OrthoDB" id="1301886at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002725">
        <property type="entry name" value="YgjP-like_metallopeptidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01863">
        <property type="entry name" value="DUF45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF45" evidence="1">
        <location>
            <begin position="54"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="154" mass="17453" checksum="87FFE8E74D29227F" modified="2015-07-22" version="1">MLIPARMSEAEEQRWVTVMLDKLQAQENRRMPGDAELADRAQRLSAQYLEGRARPSSVRWVTNQNTRWGSCTPAEGTIRLSHRLKGMPEYVIDYVLIHELAHLLVPGHGPRFWDLVGAYPRTERARGYLEGVVAGESLPFIPRPTPTTPPPARD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBG9</accession>
    <name>A0A0F7NBG9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Isopentenyl-diphosphate Delta-isomerase</fullName>
            <shortName evidence="6">IPP isomerase</shortName>
            <ecNumber evidence="3 6">5.3.3.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">IPP:DMAPP isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Isopentenyl pyrophosphate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">idi</name>
        <name evidence="9" type="ORF">AA958_24280</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>isopentenyl diphosphate = dimethylallyl diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23284"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="EC" id="5.3.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 1 Mg(2+) ion per subunit. The magnesium ion binds only when substrate is bound.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="6">Binds 1 Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from isopentenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the IPP isomerase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="5.3.3.2" evidence="3 6"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018066.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_24280"/>
    <dbReference type="EnsemblBacteria" id="AKH84814">
        <property type="protein sequence ID" value="AKH84814"/>
        <property type="gene ID" value="AA958_24280"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_24280"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5116"/>
    <dbReference type="UniPathway" id="UPA00059">
        <property type="reaction ID" value="UER00104"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004452">
        <property type="term" value="F:isopentenyl-diphosphate delta-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050992">
        <property type="term" value="P:dimethylallyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00202">
        <property type="entry name" value="Idi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011876">
        <property type="entry name" value="IsopentenylPP_isomerase_typ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018427">
        <property type="entry name" value="Isopntndiph_ism"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 6" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="8">
        <location>
            <begin position="33"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="active site" evidence="6 7">
        <location>
            <position position="70"/>
        </location>
    </feature>
    <feature type="active site" evidence="6 7">
        <location>
            <position position="119"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR018427-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH84814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="190" mass="20276" checksum="381CAE87B83EB34E" modified="2015-07-22" version="1">MLTRESQLVELVDAGGTALGSLRVAEAHTAPGRLHRAYSVMLLDEQGRILLQQRAAVKTRFALRWANACCGHPAPGQALFDAAGERLIEEIGLPGVPLQEAGVYLYRAEDPHTGRVEHEYDHVVVGLVPVGVPLKPDPAEVADVQWVAPEELRADLAARPDDYSPWLGGVLAVATNAADRLPQAAGLATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBI4</accession>
    <name>A0A0F7NBI4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_28280</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018725.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_28280"/>
    <dbReference type="EnsemblBacteria" id="AKH85491">
        <property type="protein sequence ID" value="AKH85491"/>
        <property type="gene ID" value="AA958_28280"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_28280"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5961"/>
    <dbReference type="OrthoDB" id="558559at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904823">
        <property type="term" value="P:purine nucleobase transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045018">
        <property type="entry name" value="Azg-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43337">
        <property type="entry name" value="PTHR43337"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="202"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="286"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="331"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="365"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="389"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="419"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="462"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH85491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="487" mass="49970" checksum="30DCF04320C35905" modified="2015-07-22" version="1">MTQSSVDRRAEAPSRPPGTAVSGRTSWLDRYFGISRRGSTVAREVRGGLTTFMAMAYILLLNPLVLGGEDAAGNVLAPSALITATALAAAVTTLLLGFFGKVPLAAAAGLSVSGVLASQVAPQMTWPQAMGMCVAYGVVIMLLAVTGLREMIMNAIPLALKHAITMGIGMFIALIGLVNAGFVQAGEAKIVTLGVNDQLRGWPVFVFCLTLLLIFMLQARDVPGAILIGIVAGTVAAVVVNAVAGLKPEAWANGRAPELPAGGVTSTPDFGLLGEVSFRGWGDVGVMTVGMIVFTLVLAGFFDAMATIIGVGTEAKLTDEKGRMPGLSRALFIDGAGGAVGGAAGASGQTVFVESATGVGEGARTGLSSVVAGLLFALGLLFTPLAQLVPGNVAAAALVVIGAMMMANARHVDWADRGVAVPVFLTVVLMPFTYSVTAGVAAGVISYTAIRAAQGKWREPGPFMWVLTAVLAVFFALHPIEQWMGVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBL3</accession>
    <name>A0A0F7NBL3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ubiquinone biosynthesis methyltransferase UbiE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_28720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018799.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH85566">
        <property type="protein sequence ID" value="AKH85566"/>
        <property type="gene ID" value="AA958_28720"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_28720"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6053"/>
    <dbReference type="OrthoDB" id="1664438at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="Methyltranfer_dom" evidence="1">
        <location>
            <begin position="34"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="266" mass="28661" checksum="183F91A1B5A4B0D8" modified="2015-07-22" version="1">MAVYTHGHHDSVLRSHRWRTAANSAAYLTGELRPDMHVLDLGCGPGTITADLAALVPRGRVTAVDAEEGILARARAAAAERGVANVEFAVADAEALDFPDDSFDVVHAHQVLQHLAHPVRALEEMRRVCRPGGLVAARDADYAAMTWYPDVPALDDWLDTYRRVARASGGEPDAGRRLLGWAREAGFEDVTASAGAWCFATAEERAWWSESWADRTVASSYARLAVDGGHTDAAGLARIAGGWREWGAAAGAWFAVLHGEVLCRVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBY4</accession>
    <name>A0A0F7NBY4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glyoxalase_6 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_20665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017488.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_20665"/>
    <dbReference type="EnsemblBacteria" id="AKH84202">
        <property type="protein sequence ID" value="AKH84202"/>
        <property type="gene ID" value="AA958_20665"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_20665"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4359"/>
    <dbReference type="OrthoDB" id="1984437at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041581">
        <property type="entry name" value="Glyoxalase_6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18029">
        <property type="entry name" value="Glyoxalase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyoxalase_6" evidence="1">
        <location>
            <begin position="8"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="151" mass="16933" checksum="3E8D795D6EC5185D" modified="2015-07-22" version="1">MVPTHWKLVIDATDPHAQADFWAAALGYEVEDNSPLIEQLLTAGAVPEDVLTRHRDRRAWRTAAAVRHPDDPYDPTSGTGLGRRLLFNQVPEPKPAHKNRLHLDLHPESGRREEETARLAELGAAVVRHVKEQGGEWTVMTDPEGNEFCVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NC45</accession>
    <name>A0A0F7NC45_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Aminomethyltransferase</fullName>
            <ecNumber evidence="3 7">2.1.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 7">Glycine cleavage system T protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">gcvT</name>
        <name evidence="10" type="ORF">AA958_25385</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">The glycine cleavage system catalyzes the degradation of glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>(6S)-5,6,7,8-tetrahydrofolate + (R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysyl-[protein] = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + (R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16945"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:10492"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="2.1.2.10"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the GcvT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.10" evidence="3 7"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018244.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_25385"/>
    <dbReference type="EnsemblBacteria" id="AKH84993">
        <property type="protein sequence ID" value="AKH84993"/>
        <property type="gene ID" value="AA958_25385"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_25385"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5351"/>
    <dbReference type="OrthoDB" id="282830at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004047">
        <property type="term" value="F:aminomethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00259">
        <property type="entry name" value="GcvT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006223">
        <property type="entry name" value="GCS_T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022903">
        <property type="entry name" value="GCS_T_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028896">
        <property type="entry name" value="GCST/YgfZ/DmdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013977">
        <property type="entry name" value="GCV_T_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006222">
        <property type="entry name" value="GCV_T_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029043">
        <property type="entry name" value="GcvT/YgfZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT_dom1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757">
        <property type="entry name" value="PTHR43757"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01571">
        <property type="entry name" value="GCV_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08669">
        <property type="entry name" value="GCV_T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101790">
        <property type="entry name" value="SSF101790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00528">
        <property type="entry name" value="gcvT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GCV_T" evidence="8">
        <location>
            <begin position="14"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="GCV_T_C" evidence="9">
        <location>
            <begin position="293"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AKH84993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="377" mass="39480" checksum="8230BC209D633EB0" modified="2015-07-22" version="1">MTTESPAPRRTALDATHRALGATMTDFAGWDMPLRYGSEREEHVAVRTRAGLFDLSHMGEIAVTGPQAADLLDYALVGRLSAVRPGRARYTMICREDGGILDDLIVYRLADEEYMIVANAANAQVVLDALAERAAGFPGAGVRDDRDAYALIAVQGPRSQEILGRVTDADLAGLKYYAGLPGTVAGADALIARTGYTGEDGFELFVRPADAAAVWAALTAAGADDGLVPCGLSCRDTLRLEAGMPLYGHELTTALTPFDAGLGRVVKLDKPGDFVGREALEEAAGRAAAEPPRVLVGLVAEGRRVPRAGYEVVAGGRRIGEVTSGAPSPTLGKPIAMAYVDAAHAGPGPSAATGVGVDIRGSHEPYEVVALPFYKRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NC81</accession>
    <name>A0A0F7NC81_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_25680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_026276533.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_25680"/>
    <dbReference type="EnsemblBacteria" id="AKH85049">
        <property type="protein sequence ID" value="AKH85049"/>
        <property type="gene ID" value="AA958_25680"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_25680"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5413"/>
    <dbReference type="OrthoDB" id="1635544at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007995">
        <property type="entry name" value="DUF742"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36221">
        <property type="entry name" value="PTHR36221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05331">
        <property type="entry name" value="DUF742"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="136" mass="14442" checksum="25C8DC3C4979BD16" modified="2015-07-22" version="1">MTPPPASPDSYGGAQHQPYEGEGDQPLVRPYAMTGGRTRPRYQLAIEALVSTSADPMRLQGLLPEHQRICHLCREVKSVAEVSALLTLPLGVARILVADLAEAGLVAIHQPGGGTDADGTPDVTLLERVLSGLRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NC88</accession>
    <name>A0A0F7NC88_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5 7">30S ribosomal protein S9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpsI</name>
        <name evidence="9" type="ORF">AA958_21355</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uS9 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="HAMAP" id="MF_00532_B">
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        <property type="entry name" value="Ribosomal_S9_CS"/>
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        <property type="entry name" value="RIBOSOMAL_S9"/>
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    </dbReference>
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    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005251"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00016789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH84322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="165" mass="17971" checksum="B4A4A2B386C69ECB" modified="2015-07-22" version="1">MAETTAEAPVEDVEEYTTETPAEDYTTESVAGRFGDPQPAAGTGRRKNAIARVRIVPGSGKWKINGRTLEGYFPNKVHQQEVNEPFKVLELDDRYDVVARIAGGGISGQAGALRLGVARALNEADADNNRGPLKKAGFLTRDDRAVERKKAGLKKARKGTQYSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCB6</accession>
    <name>A0A0F7NCB6_9ACTN</name>
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        <submittedName>
            <fullName evidence="5">AsnC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_26100</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85119.1"/>
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    <dbReference type="EnsemblBacteria" id="AKH85119">
        <property type="protein sequence ID" value="AKH85119"/>
        <property type="gene ID" value="AA958_26100"/>
    </dbReference>
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        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019885">
        <property type="entry name" value="Tscrpt_reg_HTH_AsnC-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13404">
        <property type="entry name" value="HTH_AsnC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00519">
        <property type="entry name" value="HTH_ASNC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="13"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH85119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="157" mass="17066" checksum="9785160003FA1B0E" modified="2015-07-22" version="1">MATHDKKQAGSALDDVSLKIVEQLQQDGRRSYAAIGKAVGLSEAAVRQRVQKLLEQGVMQIVAVTDPLTVGFMRQAMIGITVDGDVEPVADALAGLDEVDYVVVTAGSFDLLAEVVCHDDAHLLELINKRIRALPGVRATESFVYLKLRKQTYSWGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCE8</accession>
    <name>A0A0F7NCE8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ammonium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AA958_25890</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018326.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_25890"/>
    <dbReference type="EnsemblBacteria" id="AKH85083">
        <property type="protein sequence ID" value="AKH85083"/>
        <property type="gene ID" value="AA958_25890"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_25890"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5452"/>
    <dbReference type="OrthoDB" id="562287at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001905">
        <property type="entry name" value="Ammonium_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018047">
        <property type="entry name" value="Ammonium_transpt_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029">
        <property type="entry name" value="PTHR43029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00836">
        <property type="entry name" value="amt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01219">
        <property type="entry name" value="AMMONIUM_TRANSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0924">Ammonia transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="259"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="315"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="355"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium_transp" evidence="9">
        <location>
            <begin position="7"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AKH85083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="444" mass="45404" checksum="CB8EF504D350243C" modified="2015-07-22" version="1">MNGADTAFVLISAALVMLMTPGLAFFYGGMVRVKSTLNMLMMSFISLGIVSILWVLYGYSLTFGDDIGGGVLGDLDHAGMAGITPETLTGGDEGIPVLAFAAFQLMFAIITPALISGALADRVKFTAWALFIALWVTIVYFPVAHWVWGPDGFIGLNGDIKAIDFAGGTAVHINAGVAALAAVLVVGKRIGFKKDPMRPHNLPFVLLGAALLWFGWFGFNAGSELAADGVAATMLLNTQVATGAAVVGWLIYEKWRHGSVTMLGAASGAIAGLVAITPSGASVNAVGALAVGIIAGVVCAWAVGLKYKLGYDDSLDVVGVHLVGGIVGTLAIGFFAIDEIGLFYGGGLEQLGRQAAGAGVVLVYTFVVTWLLAKGIDRLVGFRVGEDEELAGVDRSQHAESAYDFSGVGSAAVAAAPGAASVGGQAAGTDRATAAAAADKRVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCF7</accession>
    <name>A0A0F7NCF7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_21735</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
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        <property type="gene ID" value="AA958_21735"/>
    </dbReference>
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    <dbReference type="PATRIC" id="fig|444103.5.peg.4578"/>
    <dbReference type="Proteomes" id="UP000034283">
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            <end position="96"/>
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            <end position="138"/>
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        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH84382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="195" mass="20377" checksum="09899314742DE511" modified="2015-07-22" version="1">MSLPDQNNPYGGPQGQQQQAQQQPAQQQQQPYGYPQYPGAGQPYPAYPGGAGPYGGGGDYPTSIPGKATAARIMMFISAGLQSLLSLLLLIGIAVAKDDFEDGFQEGSGVEVPAEAVAVVAGIYLVHAILGIVLASLFGRGAGGVRVGSIVWLSFLILFGVLALPLGIIWIALGIISIVMVANRDSGRWFARPRP</sequence>
</entry>
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
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                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">CNQ-509</strain>
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            <begin position="135"/>
            <end position="349"/>
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    </evidence>
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            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH86360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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        </source>
    </evidence>
    <sequence length="352" mass="37516" checksum="5E4134DF3C26FBDE" modified="2015-07-22" version="1">MTDRKLPHHRTLNALPYAVMGCVAIVDVTAGPGVGFLPLVSLGPAFAGLVGGWQRTVFVGGIALVLCVLLGISDVMFESRRGYVALLSVVGVTVAALLAVRMRHRREEELASVRSIAEVAQRVLLRPVPRSAGRLRAAVSYTSAVAEARIGGDLYEVVTSPAGVRLIVGDVQGKGLEAVETAAVVLSAFREAAYDEPDLTAVGERLERALDRQLDGEKFVTAILAEVGSGQEVTLLNFGHPAPLAVRHDGDVRYLAPPQRALPLGLGEHGVAQPQPHTAGFAPGDQLLFYTDGVTEARDRAGAFYPLEQRAGLLKDPDPEGALTALRQDVIEHVRAPLHDDAAMLLLRYRDG</sequence>
</entry>
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                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH85288">
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    </dbReference>
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
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            <dbReference type="EMBL" id="AKH85288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="78" mass="8383" checksum="0A92945852DD12F1" modified="2015-07-22" version="1">MFQLLALGRGRTVVAVTAVRLGLADPQPQGFLMDAQVLRDVRDWASAGADLADGALAELVGVLPWCWHLLVCLLTPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7ND34</accession>
    <name>A0A0F7ND34_9ACTN</name>
    <protein>
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        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">AA958_27455</name>
    </gene>
    <organism evidence="2 3">
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        <lineage>
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            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <sequence length="398" mass="40024" checksum="6CD8D12772FEC630" modified="2015-07-22" version="1">MAYDVVVVGAGVIGAACAEALTAAGLSVAVLDRGAPASGTTAAGEGNVLVSDKAPGPELALAQCSRRRWPPLLAELRDLLGPRRAEAEWEAKGGLVVATAPAAASALADFAAAQRTAGVRAEPVTPAEAGALEPHLTVDVTAAVHYPQDGQLQPVLATTALLAAVRERGGRVRAGVTARGVETGAGGAVTGVRTDRGTVPCGAVVNACGPWAGRFAAAAGAPVAVLPRRGLVLVTAAVPAGTVRHKVYDADYVGAVAGGTAALQTSTVVEATRAGTVLVGSSRERAGFDETVRVAVLRELARKAAGLFPVLAGVPVIRAYGGFRPYVPDHLPVIGEDPRRPGLWHATGHEGAGIGLAAGTGKLLADLFTGRAPEVPAEPFRVDRPGVMAEAEAADEPA</sequence>
</entry>
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    <accession>A0A0F7ND58</accession>
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        </submittedName>
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">CNQ-509</strain>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="103" mass="11882" checksum="74A849167ED13ADC" modified="2015-07-22" version="1">MNAHGTIDRPRAHAPAEQETTMSPSTDHPAARHEAGAYDERQNRNLQMQLMPEALARAQYRDRVEAAEQERRALRLIAARRMQRRAERAHMRARRALAMAVMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7ND94</accession>
    <name>A0A0F7ND94_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_32830</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019438.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_32830"/>
    <dbReference type="EnsemblBacteria" id="AKH86211">
        <property type="protein sequence ID" value="AKH86211"/>
        <property type="gene ID" value="AA958_32830"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_32830"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6936"/>
    <dbReference type="OrthoDB" id="2014094at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="10"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="75"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH86211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="141" mass="14874" checksum="2B59E9F2CE28C584" modified="2015-07-22" version="1">MADQQVHEIMTAAPVAVGTLTAVPEAARRMRDDDIGAVLVTDDNELRGLVTDRDLVLRVLAAGRDPGSTTVADACSQELVSVGPRERVDHAVELMRKHALRRLPVVDEGGGVLGVVSLGDVAVERDPASALSDISMAMPNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDJ6</accession>
    <name>A0A0F7NDJ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sugar phosphate isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_05865</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019812.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_05865"/>
    <dbReference type="EnsemblBacteria" id="AKH86570">
        <property type="protein sequence ID" value="AKH86570"/>
        <property type="gene ID" value="AA958_05865"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_05865"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1227"/>
    <dbReference type="OrthoDB" id="1194699at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519390" evidence="1">
        <location>
            <begin position="29"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="AP_endonuc_2" evidence="2">
        <location>
            <begin position="69"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH86570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="292" mass="30666" checksum="A66A026EBB10B9C1" modified="2015-07-22" version="1">MGRRALLTAALGAGTAAALGGAAGPAAAAEADACGGGLPGKRRIPPGGIGMHLYTMRGPLATDFAGTLQRLSDIGYATVGVSGRHGHNAQQIRGMIDDAGLSAVLEHVGWDIVSGSGLPKAIEDVHTLGGKWVVVPSLPGAMHTPAGFREAARKLNAAGRACRDAGLQQVLFHNHGNDHATVDGEVLFDILVNETDPHLVAFEFDVYWGVRGGADPLTYFRRHPGRFPALHVKDMAPNGDFADVGSGVLDFPEMFQGAESGGVKQWLVEHDNPSDPFATARNSYEYLAALRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDW4</accession>
    <name>A0A0F7NDW4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_28895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH85598">
        <property type="protein sequence ID" value="AKH85598"/>
        <property type="gene ID" value="AA958_28895"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_28895"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6088"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="71" mass="7464" checksum="70B3545D70A2AE61" modified="2015-07-22" version="1">MLSLPYEPGLPYEPGLPYEPGLPYEPGLPHVPATTAARPPGARRHAGAARHAGTRAPRAASVTRVKGAAQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDY2</accession>
    <name>A0A0F7NDY2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_29000</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018846.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_29000"/>
    <dbReference type="EnsemblBacteria" id="AKH85613">
        <property type="protein sequence ID" value="AKH85613"/>
        <property type="gene ID" value="AA958_29000"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_29000"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6110"/>
    <dbReference type="OrthoDB" id="410781at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="PTHR19375"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH85613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="534" mass="56700" checksum="2734F29E95F2E087" modified="2015-07-22" version="1">MTARIGIDFGTANTVVARSDEARGCGVPIPLDGVDLTRDGARGVAQRVIPSLLAYHHDGDRRWLGAQVTGRPGLLSDPDVTVFQATKSNVTGRAVDIPRTVGGRRISGRDAATRFLGDVTALAVLAVGADDLEIVATAPVESFDTYRDWLVQEVGAGVGAARLRVVDEATAAAVGYRARMSVGDVFCVFDFGAGTLDISIVRVEEATGAGAGVRVVSKVGADIGGNHIDALLAEHAVAAARLPTSDPVAYNRMFRALLASAETAKIALTGADRAVLDAVDPRGRTHRIPVTRAEFDHLLREADILGRVNRALRKALEGAAVRGYPSAELAGAFLVGGTSLIPAVQDLVRLHLDPGVLHLDRPLEAVATGAAGIAGGHELHDHIQHDYAIRHVDDRGGYEFEPLVPAGTPYPTAEPVKSITIRAVHHGQIRLGIAVYELTHATSRDAGADLEIVFDAHGGARTAAVTAQARQERATLWLNEDSPTFLVADPPAAVGTDRFRLDFRVDPQKRLTVSAFDIERRTWVLAEHPVVRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NE66</accession>
    <name>A0A0F7NE66_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Xylosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_29900</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018967.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_29900"/>
    <dbReference type="EnsemblBacteria" id="AKH85739">
        <property type="protein sequence ID" value="AKH85739"/>
        <property type="gene ID" value="AA958_29900"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_29900"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6314"/>
    <dbReference type="OrthoDB" id="1622507at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041542">
        <property type="entry name" value="GH43_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17851">
        <property type="entry name" value="GH43_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519546" evidence="5">
        <location>
            <begin position="35"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="GH43_C2" evidence="6">
        <location>
            <begin position="340"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH85739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="539" mass="58466" checksum="E9E1A54AD62F2818" modified="2015-07-22" version="1">MSDPLRPWSRRSVLTAATGLAAATALPLAHPAHARPAAANAALATYTNPVLWQDFADIDIIRVGDTYYYSASTMHYSPGAPILRSYDLVNWEFAGHSVPVLDFGSKYDLNGGRGYVRGIWASSLGYRPSSRTFYWVGQIDFARTYLYTAASVEGPWTRHASLGNVYYDAGLLFDDDDTPYVAYGNTAIHVAQLSPDARTQVRSQQVFSTPQSVGTLEGARFYKINGKYYIFLTRPANGQYILKSSSGPFGPYEMRQLLLNLPGPIAGGGVPHQGGLVSTPGGQWHYMAFVDAYPGGRVPALAPITWTGDGWPVLQLVNGAWGQSYTAPLPLRPVAPMTGTDTFQGTRLGPQWEWNHNPDTGRFSVGSGLTLRTATVTDDLYGARNTLTHRIQGPTSTATIELDCSQMADGDRAGLAMLRDSSAWIGLKREGGTTRVVMVDGLTMDGSWNTTGKGTERASAGFTGSRIWLRARADIRPGSGRQAQFSYSTDGSGFSPLGPAFTLNNAWQFFMGYRYAVFNHATRALGGSVRVARFDLATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NEB3</accession>
    <name>A0A0F7NEB3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 15">Replicative DNA helicase</fullName>
            <ecNumber evidence="4 15">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">AA958_16055</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 15">Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the helicase family. DnaB subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="4 15"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_16055"/>
    <dbReference type="EnsemblBacteria" id="AKH86815">
        <property type="protein sequence ID" value="AKH86815"/>
        <property type="gene ID" value="AA958_16055"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_16055"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3382"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990077">
        <property type="term" value="C:primosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016539">
        <property type="term" value="P:intein-mediated protein splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00984">
        <property type="entry name" value="DnaB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036185">
        <property type="entry name" value="DNA_heli_DnaB-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007692">
        <property type="entry name" value="DNA_helicase_DnaB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007694">
        <property type="entry name" value="DNA_helicase_DnaB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007693">
        <property type="entry name" value="DNA_helicase_DnaB-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016136">
        <property type="entry name" value="DNA_helicase_N/primase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003586">
        <property type="entry name" value="Hint_dom_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003587">
        <property type="entry name" value="Hint_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036844">
        <property type="entry name" value="Hint_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027434">
        <property type="entry name" value="Homing_endonucl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006142">
        <property type="entry name" value="INTEIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030934">
        <property type="entry name" value="Intein_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004042">
        <property type="entry name" value="Intein_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006141">
        <property type="entry name" value="Intein_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004860">
        <property type="entry name" value="LAGLIDADG_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00772">
        <property type="entry name" value="DnaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03796">
        <property type="entry name" value="DnaB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14528">
        <property type="entry name" value="LAGLIDADG_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00379">
        <property type="entry name" value="INTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00305">
        <property type="entry name" value="HintC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00306">
        <property type="entry name" value="HintN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48024">
        <property type="entry name" value="SSF48024"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51294">
        <property type="entry name" value="SSF51294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55608">
        <property type="entry name" value="SSF55608"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00665">
        <property type="entry name" value="DnaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01443">
        <property type="entry name" value="intein_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01445">
        <property type="entry name" value="intein_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50818">
        <property type="entry name" value="INTEIN_C_TER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50819">
        <property type="entry name" value="INTEIN_ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50817">
        <property type="entry name" value="INTEIN_N_TER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51199">
        <property type="entry name" value="SF4_HELICASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="6 15" id="KW-0235">DNA replication</keyword>
    <keyword evidence="14 15" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10 15 19" id="KW-0347">Helicase</keyword>
    <keyword evidence="9 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-0639">Primosome</keyword>
    <keyword evidence="13" id="KW-0651">Protein splicing</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="SF4 helicase" evidence="18">
        <location>
            <begin position="166"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="DOD-type homing endonuclease" evidence="17">
        <location>
            <begin position="488"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="domain" description="INTEIN_C_TER" evidence="16">
        <location>
            <begin position="774"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="domain" description="SF4 helicase" evidence="18">
        <location>
            <begin position="796"/>
            <end position="855"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU362085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="AKH86815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="855" mass="94513" checksum="65602BFCB3021EA5" modified="2015-07-22" version="1">MDAEQSVLGGMLLSKDAIADVVEVLKGHDFYRPAHETVYTAILDLYARGEPADPITVSAELTKRGELARVGGASYLHTLVQSVPTAANAEYYAEIVHQRAILRRLVEAGTRITQMGYAADGEVDDIVNSAQAEIYAVTEQRTAEDYLPLGEIMEGALDEIEAIGSRSGQMSGVPTGFTDLDSLTNGLHPGQMIVVAARPAMGKSTLALDFARACSIKNNLPSVIFSLEMGRNEIAMRLLSAEARVALHHMRSGSMTDDDWTRLARRMPEVTGAPLYIDDSPNLSMMEIRAKCRRLKQRNDLQMIVIDYLQLMQTGGSRRPESRQQEVSEMSRNLKLLAKELEVPVIALSQLNRGPEQRTDKKPMVSDLRESGCVTASTRVLRADTGSEVTIGELLTRGEKDIPVWSLDEQLRVVPRTMTHVFSSGVKEVFRLRLASGREIEATANHPFLTYDGWTPLGELAAGSRIATPRQIRGPVQQRAWPEAEVIMLGHLLGDGCIAPRQPVHYTSKDEANLAAVEEAAAHFGITPRRTAQGTWSHVRLPAPFRLARGRLNPIAAWLDGMGLYGKRAHEKFLPREVFALPDEQVRLFLRHLWATDGSVTVSGSGAVRVSYATTSERLARDLQQLLLRLDIRARLRAVGNTTGRPGWTVDVSGVDDQRRFLQNVGVHGDRSRHVVSAVERLRHVQANPNVDTVPRDVWEQVREQMREQSLTTRAFQAAPGTKSWGSALYKRSPGRVRLGHIAEILQSADLEMLATSDVFWDEVVSIEALGEQEVYDATVLGTHNFIANGISVHNSIEQDADMVILLHREDAYEKESPRAGEADLIVAKHRNGPTATITVAFQGHYSRFVDMAQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-12-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NEC5</accession>
    <name>A0A0F7NEC5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_25640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018292.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH85042">
        <property type="protein sequence ID" value="AKH85042"/>
        <property type="gene ID" value="AA958_25640"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_25640"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5405"/>
    <dbReference type="OrthoDB" id="1744037at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="14"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="166" mass="17986" checksum="CEB0DF6210CF12FD" modified="2015-07-22" version="1">MTTMPASRAPARTVPDVTGILMHTAHVLNTRLSAALTEVGLLQREQCVLVHALAAERTQGQLAELSRMDKTTMVVTVDGLEKAGYAERRPSSTDRRARIIHVTEAGAEVAARGQEVVDRVHQEVLDALPAAQRDVFVAALEGLMAGPLAEPVPSEQPVRRARQARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NEK9</accession>
    <name>A0A0F7NEK9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phospho-2-dehydro-3-deoxyheptonate aldolase</fullName>
            <ecNumber evidence="3">2.5.1.54</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_30765</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>D-erythrose 4-phosphate + H2O + phosphoenolpyruvate = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14717"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="2.5.1.54"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 1/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the class-II DAHP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.54" evidence="3"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_30765"/>
    <dbReference type="EnsemblBacteria" id="AKH85869">
        <property type="protein sequence ID" value="AKH85869"/>
        <property type="gene ID" value="AA958_30765"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_30765"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6503"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00084"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003849">
        <property type="term" value="F:3-deoxy-7-phosphoheptulonate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002480">
        <property type="entry name" value="DAHP_synth_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21337">
        <property type="entry name" value="PTHR21337"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01474">
        <property type="entry name" value="DAHP_synth_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU363071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH85869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="372" mass="39584" checksum="C60BD6E831FB25B6" modified="2015-07-22" version="1">MWEDTGQVRRVREALDAAPPLVTDDGAARLRRLLADVAEGRADLIQAGDCAEDPAESTPYHVRRKRDLLDALAGTAAGITGRPALRVGRMAGQFAKPRSKPVEQIGDTTLPVYRGHMVNAPEPDAQARRPDPWRILTCFRAAQAVVRELDSVNAGRPDAEQVWISHEALLLDYETPMLRRTATGASYLASAHLPWVGERTRRPDGAHVGLLAGVVNPVACKVGSGTTAEDVTELAARLDPDRSPGRLVLIARMGAGFVSSRLPALVHAVRAAGHPAVWICDPMHGNTITGPDGLKTRLMGAMLAEIHGFCDVVGAAGGINGGLHLETTPDPVTECATDVAAIGSAGRRTTFCDPRLNPGQAHRLVAAWAEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NF09</accession>
    <name>A0A0F7NF09_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_26420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020424.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_26420"/>
    <dbReference type="EnsemblBacteria" id="AKH87045">
        <property type="protein sequence ID" value="AKH87045"/>
        <property type="gene ID" value="AA958_26420"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_26420"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5562"/>
    <dbReference type="OrthoDB" id="2078866at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH87045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="76" mass="7987" checksum="EC09A4399630EA48" modified="2015-07-22" version="1">MLRRRREPVPFAFVAEADRFRSDAPVPPPVKRAGIGEIAGRALVGVLIVAGLVGAVVFGIPAMELTDDPGSAQHTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NF39</accession>
    <name>A0A0F7NF39_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_32040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019312.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_32040"/>
    <dbReference type="EnsemblBacteria" id="AKH86084">
        <property type="protein sequence ID" value="AKH86084"/>
        <property type="gene ID" value="AA958_32040"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_32040"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6765"/>
    <dbReference type="OrthoDB" id="1913352at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH86084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="1126" mass="120867" checksum="55C11CB5510AD048" modified="2015-07-22" version="1">MQPHADDLIRALEPLPYPRRLGELALAARRAAGRGELAALLDGLEGHGGYGRRLAAFAALVGRDTAFLAARLAHPDRAVRAQGMKAVRRGLLPDDAVVAAFEDAPAVVRGQLVRAVVRGRRTAVAEALIGPVGERWGDAEAARLLPACTEETVRRLLPALWPALSGPAALAGRHPGAVLDEAERQLAPLARGGRAAWWTANSRVVAPLADAAPERVLDLLERFCHGGLQPLVHERLNRLVAADPGRTLRLLLAPERRRGTAATRLPRTVLDRLVAAAPPELTELARLWQENTSSLTDLLRRTPPSRREALFDAAMAGRDTTRDDFPPDLLDALPHPRRAAEARRMAAQAREREAHPSVVLRAVACLPVAEARGELLAALRRSDADERAEAYRLLVANAARSGHPEDVTSAVRLLAERLRNDQDPVRSVALRQLAGTHPALFTADAADHLHLIAADAIAARDSSSLTRGALRTLAVALLREHAAGGRPELVSFSLRTITRLTGHTGGADLGRLDTSLRRGQEHEVFDALEPWLEAGADKVDHGLTFALARALGRRAWGMPKLQEYLWQAVQFGNDATVSTAVSLWLEPRAGRGERVGRLLALEPSAAVLPPVYAVLARSRTDLLDGVLGDTPPWGRFLTRRASWTPPVITPERWTPAQQAAAARLLARAAADAGLPLHDRARALAEVARIPGHGFDVVFRYTGADDVVLAEAALAALVWTDRPAEALPLLLAHAGGDRARVAVYAATRATRHAAPSRVEAALRPLLLPGPDGSVAKVTSRKEAVRLAAARLPAERAAVLVAGAYELPEQHRDVRAACVAFAGGLLGRPEVWGMLEAAAADDPEVRLPLLRPQPRDLREEYRPRYAGLVEAASRTEDPQLAWAAYTGLAGWAPWSPTAADVLCRAVTDLGNRGTWEPAADALVTLAINAPADDPAREPVVRAARELRVRALGQPDAEKDRDLPARRRLASLVWRLTTRTRTLRPLLRPTVHAFADVLAADDDFVPQAAVLRTEALDLEAGTAELTAALLDLAALHEGRPVLAETTAGTLGRRLDGDGRPGTPDARAEAARALAAAGGHAEGLFAVALTKSGGTRAGWPEPWRATLRTLRAHPEREVRDAALEVQTAPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NF44</accession>
    <name>A0A0F7NF44_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_31270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019181.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_31270"/>
    <dbReference type="EnsemblBacteria" id="AKH85953">
        <property type="protein sequence ID" value="AKH85953"/>
        <property type="gene ID" value="AA958_31270"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_31270"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6607"/>
    <dbReference type="OrthoDB" id="1439833at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="47"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH85953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="311" mass="32441" checksum="A68A8F52CD3497BE" modified="2015-07-22" version="1">MNRAPQPAGPEPHAAPAAPPDAPPGLAFVAAGEVELCVRDAGAGPAVVLLHGTTASLGVWDPVVDLLGGAVRTVAVDQRGHGRSGKPAAGYGAAAYTADVLALVRALGIGPVVVAGHSLGARNAVVLAAAHPDAVAGVVAVDYTPYVEPAVLDALETRVRGGDRTFASGTDVETYLHERYPLLPADAVRRRRRYGYAPAGRGGALRPLADPAAMVRTVDGLRRDFAAETRAVGVPVTLLRGEHSAIVSPRAFAATRALRPDFRAVELPGLDHYVPEEDPRTVADEIVRMLDRTTGRPRPRPATERNPDPCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFY5</accession>
    <name>A0A0F7NFY5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADPH:quinone reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_29285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018886.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_29285"/>
    <dbReference type="EnsemblBacteria" id="AKH85657">
        <property type="protein sequence ID" value="AKH85657"/>
        <property type="gene ID" value="AA958_29285"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_29285"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6175"/>
    <dbReference type="OrthoDB" id="884088at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043880">
        <property type="term" value="F:crotonyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010085">
        <property type="entry name" value="Crot_CoA_red"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01751">
        <property type="entry name" value="crot-CoA-red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="47"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="449" mass="49076" checksum="58B20C47F73335A6" modified="2015-07-22" version="1">MQEILDAITVGASGEVGHLPVPDFYRGVTLHADEVTMFDGVASRDKDPRKSLHLEEVPTPQPAPGEVLVAVLASGINHNTVWSSIFEPLPTFGFLSRYGKASPQGARHDLPYHVLGSDLAGVVLRCGEGVTPWRPGDEVVAHCLSVELSHPDGHADTMLDPEQRIWGFETNFGGLAELALVKANQLMPKPGHLTWEEAAASGLVNSTAYRQLVSANGARLKQGDTVLIWGASGGLGSYATQLVLNGGATPVCVVSSPEKAEVCRRMGAELIIDRSAEGYRFWKDEHTQDQREWRRFGTRLRELTGGEDPDIVFEHPGRETFGASVYVARRGGTIVSCASTSGFQHTYDNRYLWMHLKRIVGTHFANYREAWAANRLIAQGRIHPTLSEVVPLEQTAQAVHVVHRNLHQGKVGVLCLAPREGLGVRNPELRARHETAINRFRTGRVPAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFZ1</accession>
    <name>A0A0F7NFZ1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Acyl-CoA:diacylglycerol acyltransferase</fullName>
            <ecNumber evidence="4">2.3.1.122</ecNumber>
            <ecNumber evidence="5">2.3.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_33055</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 alpha,alpha'-trehalose 6-mycolate = alpha,alpha'-trehalose 6,6'-bismycolate + alpha,alpha-trehalose</text>
            <dbReference type="Rhea" id="RHEA:23472"/>
            <dbReference type="ChEBI" id="CHEBI:16551"/>
            <dbReference type="ChEBI" id="CHEBI:18195"/>
            <dbReference type="ChEBI" id="CHEBI:18234"/>
            <dbReference type="EC" id="2.3.1.122"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a 1,2-diacyl-sn-glycerol + an acyl-CoA = a triacyl-sn-glycerol + CoA</text>
            <dbReference type="Rhea" id="RHEA:10868"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:64615"/>
            <dbReference type="EC" id="2.3.1.20"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the mycobacterial A85 antigen family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.122" evidence="4"/>
    <dbReference type="EC" id="2.3.1.20" evidence="5"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019475.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_33055"/>
    <dbReference type="EnsemblBacteria" id="AKH86248">
        <property type="protein sequence ID" value="AKH86248"/>
        <property type="gene ID" value="AA958_33055"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_33055"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6982"/>
    <dbReference type="OrthoDB" id="1828423at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004144">
        <property type="term" value="F:diacylglycerol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050348">
        <property type="term" value="F:trehalose O-mycolyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005437219" description="Acyl-CoA:diacylglycerol acyltransferase" evidence="7">
        <location>
            <begin position="40"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH86248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="330" mass="35601" checksum="CEFEA75EC4EA6761" modified="2015-07-22" version="1">MVSETRPTRRRVLRAAGGLTAAVAAGGAGVLGAAAPAGAANDGFGLRITDRNESDPRMWYYRFATDAIGWDPGVNVLLPDGYHDSGLRYPVLYLLHGGGTDADFIQFDRLGIRALTAGRRVIVVMPDGGHAGWYSNPVSSNAGPRNWETFHIAQLLPWIDANFRTYAEYDGRAVGGFSMGGFGALKYAAKYYGHFASVSSHSGPASLRRDAGLVVHWANVSSAAVELAGGTVYGAPLWNEARVSADNPMERLGSYRNKRVFLVAGTSPDPVNWFDTANETQVLAGQREFRGALAGAGIPHEWREEPGGHVFRPEIFRQDLDGIIARLRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NGB7</accession>
    <name>A0A0F7NGB7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_01890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019716.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86494">
        <property type="protein sequence ID" value="AKH86494"/>
        <property type="gene ID" value="AA958_01890"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_01890"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046295">
        <property type="entry name" value="DUF6332"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19857">
        <property type="entry name" value="DUF6332"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="64" mass="6431" checksum="188347AA121AED30" modified="2015-07-22" version="1">MTVEIVYAAVTAALLAGAVFLAVAAPALFFDAVRGDARVGVLTAAKAAGATVFVIRVALVLRPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NGH6</accession>
    <name>A0A0F7NGH6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Zinc finger CDGSH type superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_33865</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019615.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_33865"/>
    <dbReference type="EnsemblBacteria" id="AKH86393">
        <property type="protein sequence ID" value="AKH86393"/>
        <property type="gene ID" value="AA958_33865"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_33865"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.7151"/>
    <dbReference type="OrthoDB" id="2002590at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043231">
        <property type="term" value="C:intracellular membrane-bounded organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010693">
        <property type="entry name" value="Divergent_4Fe-4S_mono-cluster"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018967">
        <property type="entry name" value="FeS-contain_CDGSH-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042216">
        <property type="entry name" value="MitoNEET_CISD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06902">
        <property type="entry name" value="Fer4_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09360">
        <property type="entry name" value="zf-CDGSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fer4_19" evidence="3">
        <location>
            <begin position="10"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="ZnF_CDGSH" evidence="4">
        <location>
            <begin position="94"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH86393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="140" mass="14861" checksum="C0FA66206173A2AF" modified="2015-07-22" version="1">MSSKTQKRAYEGKSITVTFEAGRCLHAAECVRGLPEVFDPDARPWIRPDGAGAERLAEVVRRCPSGALQYDLVDGDAEAPDRPTHVARNSAGQVLVRGELSLDTAAGPRAETRAVLCGCGQSAHQPYCDHGGPCGRTATD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NGJ1</accession>
    <name>A0A0F7NGJ1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF2201_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_30585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019070.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_30585"/>
    <dbReference type="EnsemblBacteria" id="AKH85842">
        <property type="protein sequence ID" value="AKH85842"/>
        <property type="gene ID" value="AA958_30585"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_30585"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6464"/>
    <dbReference type="OrthoDB" id="339197at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025154">
        <property type="entry name" value="Put_metallopeptidase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13203">
        <property type="entry name" value="DUF2201_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2201_N" evidence="1">
        <location>
            <begin position="40"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="485" mass="53297" checksum="3B5318BE9E704465" modified="2015-07-22" version="1">MRGDGRGTHGAPDLRRLPAAAAATVAEEPADPEVVAEARRRKEAALLDFGTGQSVVASWLYTKCHRHLATTVIPTAAVTATGDGRCTLLYNPYFFASLDFEGVKFVLFHEARHLMHRHLYVDEELRSDPVFTLAAEVAINHVALRRLGRTALPEAVPEGGGPPEPVGVDPAAVYRAYRDDLREQGLAPLPYDEFIRTDLTAYGELRRMKAPGTPPSGYCVHLAGGAAGTEVPLDPETVGQVGDDVLREVMQSALRGGRPARDELLGLADRTADGGERFSRLWGRLGLDKLRGSTPRTRRVDWWQRWLTDVLASKLTESERLVYPKKQGAIVLALGHEPMLTRRGPERTKVVLVAFDTSGSMPDAVVEWLTTLVGQTDGVESHWLSFDGTVMPFIPGERVAGGGGTDFRCVVDYAEGRLEVAGKPFPHEPDAVIVVTDGYAPHVTPADPDRWIWLITDGGDDWPERHHRPMACHRVTSERQQRRNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NH18</accession>
    <name>A0A0F7NH18_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_31705</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019255.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_31705"/>
    <dbReference type="EnsemblBacteria" id="AKH86027">
        <property type="protein sequence ID" value="AKH86027"/>
        <property type="gene ID" value="AA958_31705"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_31705"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6695"/>
    <dbReference type="OrthoDB" id="1584669at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="179"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="67"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH86027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="272" mass="29313" checksum="C7A2757AAAE0F6D1" modified="2015-07-22" version="1">MRRRPNYLAGAGSLVWLFLIGLPLYVMISATLKSQSEFAQDGPLALPDGFTLDNFTGAFDTGFGRYFLNTVLVTVCVVGIVLLLVPPLSYAIVRSRGPVTTGVFRLFLLGLAIPLQAVIVPMFYLISEAGLYDNLVGVILPTAAFCLPVSALILSGTMRDISRELFEAMAMDGASPRRVFFQLVLPLSRGGLSTIVVFSALQAWNGFLFPLVLTQSDSTKVITLGLYNFKTERGIDAPGLLAAVVLSMIPVLLVYLFARRALVQGLMGVGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-12-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NH57</accession>
    <name>A0A0F7NH57_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_15070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86784">
        <property type="protein sequence ID" value="AKH86784"/>
        <property type="gene ID" value="AA958_15070"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_15070"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3175"/>
    <dbReference type="OrthoDB" id="1389691at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004343">
        <property type="term" value="F:glucosamine 6-phosphate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039143">
        <property type="entry name" value="GNPNAT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13355">
        <property type="entry name" value="PTHR13355"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="127" mass="13368" checksum="6799C36AA6AEF037" modified="2015-07-22" version="1">MPSVADYRRLRTGAGLSDKAAEAAAVGLPQTWYGVVVYHRGVPVGMGRVVGDGGTVFQVVDMCVLPDHQGQGLGKQIMAELVAELDRRAPATAYVSLVADGPARFLYEKFGFADVAGHGSLGMYRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NHK0</accession>
    <name>A0A0F7NHK0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ArsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_32895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019449.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86222">
        <property type="protein sequence ID" value="AKH86222"/>
        <property type="gene ID" value="AA958_32895"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_32895"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6949"/>
    <dbReference type="OrthoDB" id="1617768at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="258"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="341" mass="36938" checksum="9D695B8BC4BCE234" modified="2015-07-22" version="1">MLRIHFTDVDLARTRLAPAPDPMFEIAASLHRLQSRGGRWAYAGWYRSARQRLREAGLERVLRSVLLPLYPRAAYFPDFLTPADAVNGLDAGLESILDTPPRRVVEEMTILDRTVGAPAWAGQLAGREERKEFAGILRAYFDGVVAPHAEQVQARIEAERAARCRGLLDGGVEGMLAGLRPMLRWSPPVLEVAYPRQAEDRDLYLNGRGLTLVPSYFNWGEPVAFADPGLPPVVWYSLLHEPEARSVTDGAPEQSLTNLFGRARAVALRAASAGATTGEIARAAGVSASAASRHATALRDAGLITTVRHGPAVLHTLTPTGASVLRAAMRRAEDDVTGTAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NIH5</accession>
    <name>A0A0F7NIH5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_27745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
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        <property type="protein sequence ID" value="AKH87068"/>
        <property type="gene ID" value="AA958_27745"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_27745"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5847"/>
    <dbReference type="OrthoDB" id="1332946at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="498"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH87068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="520" mass="54969" checksum="FE2817743B4030DC" modified="2015-07-22" version="1">MTVAAITAATVLVVLGLGGEGACGDGLVESANGEECVGVADATAESPAFAPGADGPDERIADLVRQIGAENERVRAGWEDDDSSAREPYVRVGLMMPFNATESSAMTPEVVQNTLAGVLTAQLAANRGQGVNYQLLLANVGKDLSQWRPAVDALAALTTGRAPTRGDSPLVGVVGLPNSEQDTEDAAVALSRADIPAVSGVLSSPEISADTLFKSAPSNTESVAALADYLEGHPGARPGKPSGYLVWDSRKEDDYVTNTRDNMRDVFGEEYQLENRSSSFVGIMGDYKGAPRRFSPAARGICRLEADTVFYAGRDSDLPYLITQLSDEPECDDFDTEIRILRVATGLPEGLTGEQVRADMAEARVVTVGASATDAPSWRAGDGADERFTTFATGFAKVSGLPGEALDDGYAIMHHDAFTVLAQAVGTALDDLNRPDGGESDRLPSKLDVYNTITNMKVVAGGDPCQDCVHGASGQFGFDVEKDNWPVCKPVPVIEYPRPEDADRPRPYRTFQAPDGTCPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NIM1</accession>
    <name>A0A0F7NIM1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_29690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020528.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_29690"/>
    <dbReference type="EnsemblBacteria" id="AKH87123">
        <property type="protein sequence ID" value="AKH87123"/>
        <property type="gene ID" value="AA958_29690"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_29690"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6268"/>
    <dbReference type="OrthoDB" id="447734at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="376"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH87123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="400" mass="42145" checksum="0C9DB837F67CBF96" modified="2015-07-22" version="1">MTAPAACSSKTGGTGGDQSDDTYTWWDPYPQHDKSSDWAKRVTACGDEAGVTIKRTAYDTSALTNQALLAAQEGTSPDVILLDNPAVSTLADSGMLTTTDEFGLDTSGIDENLLAAGVVDDKAYGIPIGANTLALYYNEDVLDDAGVDPASVEDWESLTAALRKATGAGHKGITFAGTNTEEGSFQFLPWFWGAGAELRDLDSAQAVSALELWTGWLAEGYAPNSVINNSQNTTWEEFLTGDFAFAVNGTWQVNSAAEAGFPTGVVQIPGKDGGAAPAPTGGEFITAPMQDDTSRYDVTKKIVECMTTPAGMVETATTFAYYIPPTRAGQEKLLAKNAGLKPWTEAVRTARGRTSDNLGTDYPKISEQLWTAVQKALSGSTSPEDALREAQSAAEDEAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MYR2</accession>
    <name>A0A0F7MYR2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alkaline phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_00345</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH80871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014237.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_00345"/>
    <dbReference type="EnsemblBacteria" id="AKH80871">
        <property type="protein sequence ID" value="AKH80871"/>
        <property type="gene ID" value="AA958_00345"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_00345"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.84"/>
    <dbReference type="OrthoDB" id="1629121at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014036">
        <property type="entry name" value="DeoR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018356">
        <property type="entry name" value="Tscrpt_reg_HTH_DeoR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00455">
        <property type="entry name" value="DeoRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08220">
        <property type="entry name" value="HTH_DeoR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00037">
        <property type="entry name" value="HTHLACR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00420">
        <property type="entry name" value="HTH_DEOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00894">
        <property type="entry name" value="HTH_DEOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="4">
        <location>
            <begin position="3"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH80871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="266" mass="28061" checksum="916B50E62B02D523" modified="2015-07-22" version="1">MSKHDRWSRLLQHLAENGRLEVEEAASVLEVSAATIRRDLDELAEQQLLVRTRGGAIAHGVSYELPLRYRSVHNAAEKRRIAEAVADQIGQGIVVGINGGTTTTEVARALIIRAAGDGAEQVAGTPAPSVTLVTNALNIASEAAVRPQIKLVLTGGVARPQTYELVGPLASGVMSDVALDVAILGVDGVDSSLGLMTHHEEEASISRLFAERAHRVIVAADSSKLGRRAFARICGLDRIDVLVTDSAASGDMIARLTDAGIEVISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MYR9</accession>
    <name>A0A0F7MYR9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HIT family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_03365</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014739.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_03365"/>
    <dbReference type="EnsemblBacteria" id="AKH81380">
        <property type="protein sequence ID" value="AKH81380"/>
        <property type="gene ID" value="AA958_03365"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_03365"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.715"/>
    <dbReference type="OrthoDB" id="1934382at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01275">
        <property type="entry name" value="FHIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039383">
        <property type="entry name" value="FHIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="SSF54197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="4">
        <location>
            <begin position="49"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="3">
        <location>
            <begin position="143"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-AMP-histidine intermediate" evidence="2">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR639383-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH81380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="186" mass="19970" checksum="0B684ABF5C5231FF" modified="2015-07-22" version="1">MLLSMTSEPEQQLGVGTPDQFQRLWTPHRMAYIQGENKPTGTAAGDGCPFCAIPEKSDEDGLILARGAQVYAVLNLYPYNGGHLMVVPYRHVADYTELTGEETAELAVFTKRAMTALRAASGAQGFNLGMNQGPVAGAGIAAHLHQHVVPRWGGDTNFMPVVSHTKVLPQLLADTRAMLAAAWPAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MYV9</accession>
    <name>A0A0F7MYV9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CRISPR-associated protein CasC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_03700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014798.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_03700"/>
    <dbReference type="EnsemblBacteria" id="AKH81440">
        <property type="protein sequence ID" value="AKH81440"/>
        <property type="gene ID" value="AA958_03700"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_03700"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.779"/>
    <dbReference type="OrthoDB" id="922733at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010148">
        <property type="entry name" value="CRISPR-assoc_prot_CT1975"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09344">
        <property type="entry name" value="Cas_CT1975"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01869">
        <property type="entry name" value="casC_Cse4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="408" mass="44001" checksum="DBC065EE502B8FAF" modified="2015-07-22" version="1">MSRTVVDIHVLQTVPPSNLNRDDTGTPKSAVYGGVRRSRVSSQAWKRATRTAFRQLLDPAELGVRTKKVAELIGETIRELQPVVTPEESWELAKAVVEAGTGASLAVPERKKPKKNKNSAKAAEEAEGAEEAKPLPPESKYLMFLSAQQRRGLAELAVEGREDIGGFLKAKANKERAREIADTRHSVDIALFGRMVADGADINVDAAAQVAHALSVHAVENESDYYTAVDDRNEADETGAGMIGTVEFNSATLYRYAALDVDRLADNLGQGVAEDADRATPVRRAVEAFVRGFVSSLPTGKINTFAHHTPPDAVVVKLRERRSVNFVGAFEEPTMAESGSGHVRQASERLAEQIADVEREFGEEALATWVVLAGRNTAKLAEAGTRVTLDELVASVGAAVAERQGGRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MZR2</accession>
    <name>A0A0F7MZR2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_05860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015158.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_05860"/>
    <dbReference type="EnsemblBacteria" id="AKH81805">
        <property type="protein sequence ID" value="AKH81805"/>
        <property type="gene ID" value="AA958_05860"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_05860"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1226"/>
    <dbReference type="OrthoDB" id="1262147at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="562"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="589" mass="62750" checksum="830CE56F2D45CA1A" modified="2015-07-22" version="1">MGPDELSPPERRLWEAFPTAGHVDLRTGDPAADDPVRGAAWGPERVVRAEVVAALLLGARDGESGHTAAVQLTGARITGRLALDHADVQHHLRLQDCSFEESADLYGARTRQLSFNGSHLPGLLASHLWAEGSLRFTGCTTSGKIRLVATRIAGTLILNGARLHDPGGEVLNATRLQVDNDILMRDDFSAQGTVVLRSARIGGSLDLRTARLDAGSGEAALDAARVQVDGDFSAYRLSATGRLGLRNATVAGATFLRSASLDNPDGRTLDAPGMHVGSDVVLDKHFRSHGQIRLADATVGGRLVMSGATLRAEADDAALDAYGIQIGADAVLDHVTATGLVRLSGAQITGRIEADGSRISGHTPGATALSLRRTTAREADMRTTRLDGALDMRYSALGVLHDAAATWPPRVRLDGAVYEQLHDPLAAAERLPWLSRGDSAYVPQPYEQLAAVYRHLGHEDDARRVLLAKQRARRRQLPWYARVWGAVQDAVVGYGYRPERAVAWLAGLLALGSLLFSAKEPRPLEPGKEIEFNPFVYTLDTLLPVVDFGQGNAFAPGGGAQWVAYVLAAAGWILATAVAAGAARALNRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0F7</accession>
    <name>A0A0F7N0F7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glutamine synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_03850</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutamine synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014823.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_03850"/>
    <dbReference type="EnsemblBacteria" id="AKH81466">
        <property type="protein sequence ID" value="AKH81466"/>
        <property type="gene ID" value="AA958_03850"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_03850"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.809"/>
    <dbReference type="OrthoDB" id="416474at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamate-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="SSF54368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gln-synt_C" evidence="2">
        <location>
            <begin position="122"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH81466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="463" mass="51009" checksum="E83364DCA3257B7D" modified="2015-07-22" version="1">MTDSARTPALPVPELRRLVEAGELDTVVLAFTDMQGRLQGKRFAAPFFLDEVLAHGTEGCNYLLAVDADMNTVEGYEMSSWERGYGDFAMHPDLATLRRIPWHPGSAMVTADLAWHDGAPVTASPRQVLRRQLDRLAERGWTAYAGTELEFMVFKDTYEQAWNSAYRDLTPANQYNVDYSVLGTGRVEPLLRRIRNEMAAAGMTVESAKGECNLGQHEIAFRYDDALTTCDQHSIYKTGAKEIAAQEGTALTFMAKYDEREGNSCHIHLSVRDADGAPVFAAPGGPDDGDAPYGMSETMRHFVAGQLACLPELTLLYAPNINSYKRFRPGSFAPTAVAWGPDNRTCAIRVVGHGGSLRLENRLPGGDVNPYLAVAGMIAAGLHGVERKLELPEACTGNAYTGDAAHVPATLRDAAELWSGSTLAREAFGEDVVRHYRNMARVEQEAYDTAVTDWERFRSFERM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0Z3</accession>
    <name>A0A0F7N0Z3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF1080 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_08620</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015633.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_08620"/>
    <dbReference type="EnsemblBacteria" id="AKH82285">
        <property type="protein sequence ID" value="AKH82285"/>
        <property type="gene ID" value="AA958_08620"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_08620"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1818"/>
    <dbReference type="OrthoDB" id="365211at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010496">
        <property type="entry name" value="3-keto-disaccharide_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06439">
        <property type="entry name" value="DUF1080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519144" description="DUF1080 domain-containing protein" evidence="1">
        <location>
            <begin position="33"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1080" evidence="2">
        <location>
            <begin position="45"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH82285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="222" mass="23519" checksum="D0A892CEA4044E4F" modified="2015-07-22" version="1">MPTPHRRISLRAALVAAAAGCLLTAAPASVPAATTPPAPAAERLVLFDGTGTEGWSQAGPGGFTLADGALTSYGGLGLIWYSGREFGTRYHLTLDWRMAGDDNSGVHLGFPAGDDPAIRNSGFEVQIDATDSPDRTTGAVYGFQSPDIAARDAALRPPGEWNTYDLRVDGDRLTVELNGVRINDYTDTVPERRLGPGHIGLQNHGTGDEVSFRNIVIEVYGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N126</accession>
    <name>A0A0F7N126_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fuculose phosphate aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_05270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015060.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_05270"/>
    <dbReference type="EnsemblBacteria" id="AKH81706">
        <property type="protein sequence ID" value="AKH81706"/>
        <property type="gene ID" value="AA958_05270"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_05270"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1106"/>
    <dbReference type="OrthoDB" id="599627at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="SSF53639"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldolase_II" evidence="1">
        <location>
            <begin position="6"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="210" mass="22183" checksum="DA7EBD206626B71E" modified="2015-07-22" version="1">MRHAWRELLATARRMYSEGLVVGTSGNVSARMGDHVLITPTGVPYEELGDDDLVAVDLRGRQTHGSLKPTSELPMHLAVYENTDASAVVHTHAVHATAVSTLVPELPTVHYATAALGGPVRVAPYALYGTPELAAGMLTALAGRSACLLQNHGTVAYGAGLAQAYDRTAQLEWMCRVWLAARSAPGLSPSLLSAEELGEVAEKLKGYGQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N1D3</accession>
    <name>A0A0F7N1D3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_02520</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014596.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_02520"/>
    <dbReference type="EnsemblBacteria" id="AKH81233">
        <property type="protein sequence ID" value="AKH81233"/>
        <property type="gene ID" value="AA958_02520"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_02520"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.539"/>
    <dbReference type="OrthoDB" id="1688736at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="240"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="285"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="99"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH81233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="322" mass="35132" checksum="8D133887DB996031" modified="2015-07-22" version="1">MTDTVGTADAAKPVRVRRRIPVRTPHQAARNTSTRRLGGPFAGVPWALPALALVGVLLLYPFLRSIYGSFFEDNGFTSSFTGVDNYTRLAEDPIFGRSLLNTFMWVAGTLLLPVVAGLAIAVATHRMRRFGGLAQLVIVLPFAISGAATAALWRFMLTTDGAVNEILRGVGLDSWAQSWLLEWPQNTLSMIVASTWQATGLNVVLFAIGLRAIPRETIEAAELDGATGWRMFRHITLPQLRAVTVVVVGMAIVNSLKAFDMIWVLTQGGPSRSSETLALTMYREAFRLFHVGYGSAIALVLSVIVVASSWLYLRRQMPGAKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N1J6</accession>
    <name>A0A0F7N1J6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ricin B-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_02620</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014612.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_02620"/>
    <dbReference type="EnsemblBacteria" id="AKH81249">
        <property type="protein sequence ID" value="AKH81249"/>
        <property type="gene ID" value="AA958_02620"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_02620"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.560"/>
    <dbReference type="OrthoDB" id="194265at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012878">
        <property type="entry name" value="Glyco_hydro_127"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019546">
        <property type="entry name" value="TAT_signal_bac_arc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07944">
        <property type="entry name" value="Glyco_hydro_127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14200">
        <property type="entry name" value="RicinB_lectin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10518">
        <property type="entry name" value="TAT_signal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="SSF50370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01409">
        <property type="entry name" value="TAT_signal_seq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519033" description="Ricin B-type lectin domain-containing protein" evidence="1">
        <location>
            <begin position="33"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B-type lectin" evidence="2">
        <location>
            <begin position="667"/>
            <end position="805"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH81249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="809" mass="88078" checksum="E3FFD136E5B3B941" modified="2015-07-22" version="1">MPPPLNRRHFLHASAAGAGALALGATALPAHAYGPAAGRAAGTPYAAAAFGKLPLGSVTARGWLAGQLGTLLGGLFGRYDRISHFLDHDGSGWVHPDRAGWEEVTYWLRGYVSLAALTGDSAAQATARRWIDAILATGQPDGFFGPTRLRTALNGGPDFWPYLPLLQALRSHEEFTGDERIVPFVLPFLRYMNAQGKGAFDSSWVSKRWGDGIDIAYWLHARTGEDFLLELTDKMHRWGGNWVDNFPDLHNVNVAQGFREPAQYALRAGDAALTRATYRGYERILAEYGQFPGGGFAGDENARPGFGDPRQGFETCGIVEFMASHELLTRITGDALWADRCEELAFNLLPAATDPAGRGVHYATSANSIDLDDVRKNDGQFQNGFAMQSFQPGVDQYRCCPHNYGMGWPYFTEELWLSTPDGGLAAAMYAPCEVRTRVRGTEVTITEETDYPFTEIVTLRIGAARKVPFTLRLRVPGWCDAPEVTVNGRPVTAAPGPGFAPVKRTWARGDTVVLRLPQRTSVRVWDANGGAVSVDRGPLTYALRIGESYERIGGSDDFPHFAVHATTPWNYALAPDAPAGLAFHRDDGPLTGDPFTHEHTPVRITAPARRLPEWVADRQRVVAPLQQSPARSTETPEAVTLIPMGAARLRITAFPTADPDGTPWTPEPPHHRVENKHSGKVLAVDRMSLSDGARVHQFDNSGTSDHSWQLLERGDGLLVIRNGHSGKVLAVDGGSTANSAPVVQYEDDGAPDHLWRIVPDADGWFRIRNEHSGKVLGVDGMSASNSAQVVQYDDNGTADHLWRLAAAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N217</accession>
    <name>A0A0F7N217_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Indole-3-glycerol-phosphate synthase</fullName>
            <ecNumber evidence="3">4.1.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_00535</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+) = (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:23476"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="EC" id="4.1.1.48"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.48" evidence="3"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH80902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014268.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_00535"/>
    <dbReference type="EnsemblBacteria" id="AKH80902">
        <property type="protein sequence ID" value="AKH80902"/>
        <property type="gene ID" value="AA958_00535"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_00535"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.124"/>
    <dbReference type="OrthoDB" id="1789381at2"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00043"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004425">
        <property type="term" value="F:indole-3-glycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045186">
        <property type="entry name" value="Indole-3-glycerol_P_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013798">
        <property type="entry name" value="Indole-3-glycerol_P_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22854">
        <property type="entry name" value="PTHR22854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00218">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IGPS" evidence="7">
        <location>
            <begin position="12"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="244"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH80902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="284" mass="29278" checksum="9D66C42856B1B085" modified="2015-07-22" version="1">MTFPAESTPVKATDQRFGDALAVADLPVIMEIKQCRAGGENLMQGRTAGDLVRRYEELGAPALSVLTGSWFGGTARLLDEVVAATSLPVLVKDFFTKEKQIRQAAEAGAAAVLLTATILPHRLMGVLIDACLAHGVTPFVEITSGAELSALTRPEACVVAVNNKDVRGRESDEPDLGRSHDLLPRVRAAGAGLAVSASGIATPEKAAGLLAAGFRGLLIGTGLLRAEDMDAWFGDLRALLPGAEQAAGDGPRRHADESSVRTAAAGPAERAAARSAQSPGAAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N238</accession>
    <name>A0A0F7N238_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Translation initiation factor IF-3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">infC</name>
        <name evidence="8" type="ORF">AA958_03805</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the IF-3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_03805"/>
    <dbReference type="EnsemblBacteria" id="AKH81458">
        <property type="protein sequence ID" value="AKH81458"/>
        <property type="gene ID" value="AA958_03805"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_03805"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.800"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00080">
        <property type="entry name" value="IF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036788">
        <property type="entry name" value="T_IF-3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036787">
        <property type="entry name" value="T_IF-3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001288">
        <property type="entry name" value="Translation_initiation_fac_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019815">
        <property type="entry name" value="Translation_initiation_fac_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019814">
        <property type="entry name" value="Translation_initiation_fac_3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10938">
        <property type="entry name" value="PTHR10938"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00707">
        <property type="entry name" value="IF3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05198">
        <property type="entry name" value="IF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54364">
        <property type="entry name" value="SSF54364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55200">
        <property type="entry name" value="SSF55200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00168">
        <property type="entry name" value="infC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4 8" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IF3_N" evidence="7">
        <location>
            <begin position="2"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="IF3_C" evidence="6">
        <location>
            <begin position="69"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="155"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH81458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="187" mass="21188" checksum="BB9CC6EEA6E9C3D9" modified="2015-07-22" version="1">MRLVGPSGEQVGIVPLAKALELAQEYDLDLVEVAANARPPVCKLMDYGKFKYESAMKAREARKNQAHTVIKEMKLRPKIDPHDYDTKKGHVERFLKQGDKVKITIMFRGREQSRPELGRRLLQRLAEDVQELGFVESNPKQDGRNMIMVLGPHKKKTEAMAEAREAQAARKAERRGDDNAPAERAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N273</accession>
    <name>A0A0F7N273_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribonuclease II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_07525</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015456.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_07525"/>
    <dbReference type="EnsemblBacteria" id="AKH82106">
        <property type="protein sequence ID" value="AKH82106"/>
        <property type="gene ID" value="AA958_07525"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_07525"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1577"/>
    <dbReference type="OrthoDB" id="1602988at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001900">
        <property type="entry name" value="RNase_II/R"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00773">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00955">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNB" evidence="2">
        <location>
            <begin position="52"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="449"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="480"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH82106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="561" mass="59481" checksum="3DEBF78DA3236930" modified="2015-07-22" version="1">MPQRILHTADAEDAPLHAALRRLRAAEDVSAEFPPEVLAEADRAAKAPRLPERDATDIPFYTVDPPGSRDLDQALHVARRGGGGFRIRYALADVAAFVTPGGALDAEAHRRVTTLYFPDIRVPLHPGQLSEGAASLLPDQTTPALLWEIDLDSSGQVAEATVARALVRSRARLDYGAVQQTIDEGTAEEPVALLRDVGLLREEVERERGGISLGVPEQEVVRRDGRYTLEYRAPLPAHSWNAQVSLLTGMAAADLMLASGTGILRTVPPARHSALTYLHRIARALDIDWPEGLDYPELLRSLNPQMANHAAFLQDCTTLLRGAGYTVFDGEPPARQDAVHAAVADEYAHCTAPLRRLADRYALELCVAAAAGEPAPEWVREALGGLPELMVRGAQRAARLERECVDLVEAALMSGRIGEVCDGYVVAVDERRPTRGTVQLYEPAVIGRVDTEDAEGGPVFSAAGEDAEGAEGAEGAEPPGGTEPPAPAAGAPPAGPAEPAESAESAESAESADGAEPADAAGPPLRAWPAPGEPLPLGHRVRVRLTAAEPGVSPVRFAPEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N276</accession>
    <name>A0A0F7N276_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_11175</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016038.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_11175"/>
    <dbReference type="EnsemblBacteria" id="AKH82700">
        <property type="protein sequence ID" value="AKH82700"/>
        <property type="gene ID" value="AA958_11175"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_11175"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2355"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="8"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="313"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="366"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="549"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="326"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="442"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="549"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH82700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="575" mass="60598" checksum="C463EF2DAF4093CE" modified="2015-07-22" version="1">MRPVGSKYLLEEPLGRGATGTVWRGRQRETAGAEAAVAGSPGEVVAIKVLKEELAGDPDVVMRFLRERSALLRLTHPNIVRTRDLVVEGDLLALVMDLVDGPDLHRYLRDNGPFTPVGAALLTAQIADALAASHADGIVHRDLKPANVLLAGGTGPDGTGRMQPMLTDFGIARLADSPGLTRAHEFVGTPAYVAPESAEGRPQTSAVDVYGAGILLYELLTGRPPFGGSSALEVLHQHLNQEAQRPPGLPDPMWTVVQSCLRKNPDERPSAENLARGLRTVAAGIGAGAAPEQATAALGVAALLAADPHPAQVPGTGAGASDPTQILPGGSGSAAGQQGAYDPNAATSVLPAGAAGAAAGAGAGAAAHAQQGPGAPGSEDGTRVMPVTEGPPQPEGPHPWETQMRAARDRGEQTQQIGYLDPSEDPLRRRPPRRVQRRQPPPEAYAAPPQRREPPPQRYEPRPQPPAPPPQPPRERRRSANPMRIPGLGCLKGCLFTVLILVVGSWLIWELTPVQDWIADGKGFWDQMTDWATDLKNWISEFNDAADDAQKTKDDIDSGVNDVEKGIDGLKNGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2A7</accession>
    <name>A0A0F7N2A7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">IMPACT family member yvyE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_01140</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IMPACT family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014367.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_01140"/>
    <dbReference type="EnsemblBacteria" id="AKH81002">
        <property type="protein sequence ID" value="AKH81002"/>
        <property type="gene ID" value="AA958_01140"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_01140"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.251"/>
    <dbReference type="OrthoDB" id="1777855at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023582">
        <property type="entry name" value="Impact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015796">
        <property type="entry name" value="Impact_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001498">
        <property type="entry name" value="Impact_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036956">
        <property type="entry name" value="Impact_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015269">
        <property type="entry name" value="UPF0029_Impact_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020569">
        <property type="entry name" value="UPF0029_Impact_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16301">
        <property type="entry name" value="PTHR16301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09186">
        <property type="entry name" value="DUF1949"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01205">
        <property type="entry name" value="UPF0029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00257">
        <property type="entry name" value="IMPACT_YIGZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00910">
        <property type="entry name" value="UPF0029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UPF0029" evidence="2">
        <location>
            <begin position="20"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1949" evidence="3">
        <location>
            <begin position="140"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH81002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="208" mass="21628" checksum="4F322FF5075BE738" modified="2015-07-22" version="1">MREGYLTVARAGVHETEVNRSRFVCTLAPAATEAEAQAVLAQVRAAYPDATHHCFAYVIGADAGVQRSGDDGEPGGTAGLPMLQLLLRRELRYVVAVIARYFGGTKLGAGGLIRAYGGAVGAAVDALGTVTRLRMRLVTVTVDHGRAGKVLGHLHAAGRDVRGVVYGESVGIEVAVPAAELDAFRSWLADATAGSAELRPGDEVYGTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2C6</accession>
    <name>A0A0F7N2C6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Chemotaxis protein CheY</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_11505</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016091.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_11505"/>
    <dbReference type="EnsemblBacteria" id="AKH82755">
        <property type="protein sequence ID" value="AKH82755"/>
        <property type="gene ID" value="AA958_11505"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_11505"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2421"/>
    <dbReference type="OrthoDB" id="817710at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="3"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="124"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="124"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH82755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="224" mass="24897" checksum="7712A04DAD45EF5F" modified="2015-07-22" version="1">MTRVLLAEDDAAISEPLARALRREGYEVEVREDGPTALGAGLRGGVDLLVLDLGLPGMDGLEVCRRLRADGHGFPVLVLTARADEVDTVVGLDAGADDYVTKPFRLAELLARVRALLRRGSTEAQPPATHGVRIDTDSHRAWLGEEELQLTAKEFDLLRVLVRDAGRVVTREQLMREVWDTTWWSSTKTLDMHISWLRKKLGDDAANPRYIATVRGVGFRFEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2H1</accession>
    <name>A0A0F7N2H1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chitin-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_01495</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014422.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_01495"/>
    <dbReference type="EnsemblBacteria" id="AKH81057">
        <property type="protein sequence ID" value="AKH81057"/>
        <property type="gene ID" value="AA958_01495"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_01495"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.328"/>
    <dbReference type="OrthoDB" id="1005693at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004302">
        <property type="entry name" value="Cellulose/chitin-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03067">
        <property type="entry name" value="LPMO_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519094" evidence="1">
        <location>
            <begin position="31"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-4" evidence="2">
        <location>
            <begin position="31"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH81057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="171" mass="18634" checksum="8C0180C9662CC9BB" modified="2015-07-22" version="1">MRSLKKRAAIVAATVTPLVVLALPAPQASAHGWITSPPSRQQQCKAGTVSCGQIQWEPQSVEGPKGLTSCHGGNSRFAELNDDSKGWAVTDINRTQSFNWQITANHRTSTWQYFVGGQKVAEFNDGGAQPPSQFSHTVNFGNITGRQKVLAVWNVYDTANAFYACIDVNIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2H2</accession>
    <name>A0A0F7N2H2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AA958_04530</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014934.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_04530"/>
    <dbReference type="EnsemblBacteria" id="AKH81579">
        <property type="protein sequence ID" value="AKH81579"/>
        <property type="gene ID" value="AA958_04530"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_04530"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.955"/>
    <dbReference type="OrthoDB" id="760677at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="9"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="134"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="249"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH81579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="407" mass="44704" checksum="E1413EE4D677F6DD" modified="2015-07-22" version="1">MDFAPDARTEELRERLLAFMTEHVLPAEPVAAAQLAGEDDPWAHPPVVAELRAEARRRGLWNLFLPDTVYGAGLTNLQYAPLAEITGRSPHLAPLALNCSAPDTGNMELLAQFATPEQRARWLEPLLEGRIRSAFAMTEPAVASSDATNIETRIERDGDSYVLDGRKWYISGAMNPDCAVFIVMGKTDPHGTDLRRQQSMVLVPRDTPGLTVRRAMRVYGFEDRLHGGHAEIVLDGVRVPAANLVGEEGGGFAIAQARLGPGRIHHCMRLIGMAERAIELMCRRAVERSAFGKELARQGVVQTWIADARVAVEQLRLLVLKTAWLMDTVGNRGAHTEIQAIKIAVPREVTGILDRAVQLHGAAGVSQDTPLAELWASARTLRLADGPDEVHQRSLARRELRKYARGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2K1</accession>
    <name>A0A0F7N2K1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha-L-fucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_01700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014456.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_01700"/>
    <dbReference type="EnsemblBacteria" id="AKH81092">
        <property type="protein sequence ID" value="AKH81092"/>
        <property type="gene ID" value="AA958_01700"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_01700"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.372"/>
    <dbReference type="OrthoDB" id="179460at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004560">
        <property type="term" value="F:alpha-L-fucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016518">
        <property type="entry name" value="Alpha-L-fucosidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027414">
        <property type="entry name" value="GH95_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14498">
        <property type="entry name" value="Glyco_hyd_65N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007663">
        <property type="entry name" value="UCP007663"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519100" evidence="1">
        <location>
            <begin position="35"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hyd_65N_2" evidence="2">
        <location>
            <begin position="46"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH81092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="782" mass="85196" checksum="0D4FD5E1B2A6877D" modified="2015-07-22" version="1">MTEGISRRTTVKSAIGAAGAIAMGPAVFSGEAFASESVDSSDELSLWYDKPAADWERESLPLGNGALGVGVFGTLASEQLTLNEKTLWTGGPGSPGYDFGNWTEPRPGALEAVQDRIDAEGRLSPETVAAELGQPKHGFGAYQVLGHLRLDLPAAPGAPDASYRRGLDLRRAVATVAYEHEGARHLREFFVSYPDGVAVARLSADRPGRVAFTLRYTSPRNDYTATASGDRLTIRGALQDNGLVFETQIRLVAEGGKVTAGDGTLTVTGADAAWFVLAAGTDYADTYPDYRAADPHERVMLAVDRAARSPYTKLVQRHVADHGELFDRVALDVGGQAPDVPTNALLAGYGSGSAADRALEALFFQYGRYLLIASSRPGSTPANLQGVWNNVTNPPWSADYHVNINLQMNYWPAEVTNLAETTVPYDEFVEALRAPGRVSAKELFGTDGWVVHNETNPYGFTGVHNWATAFWFPEAAAWLTQQMYEHYRFDGSTDYLRNTAYPVMKEAARFWLANLRTDPRDGKLVVTPSYSPEQGDFTAGASMSQQIVYDLLTSTLEAARTLGDDRAFRGRLERALRDLDPGLRIGSWGQLQEWKADLDDQNNDHRHVSHLFALHPGRQIEVGSEWAEAAKVSLTARGDGGTGWSKAWKINFWARLTDGDHAHKMLSEQLKSSTLPNLWDTHPPFQIDGNFGATSGIAEMLLQSQHGPIEVLPALPGAWPSGSVRGLRARGGATLDITWDEGRATRIVLHASRTRRLTLRSDLLPGGEEIVNARAGRSYTFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2N5</accession>
    <name>A0A0F7N2N5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_08520</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015619.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH82271">
        <property type="protein sequence ID" value="AKH82271"/>
        <property type="gene ID" value="AA958_08520"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_08520"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1798"/>
    <dbReference type="OrthoDB" id="2047542at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="27"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH82271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="213" mass="22908" checksum="71B0DF3A87110231" modified="2015-07-22" version="1">MPSRESGEPAESAGRRPAPRRRRADAERSRSAIVDAAVRLLGERPEASVEAIAAAAGVTRQTVYAHYPSRNEVLSAVFDRVTAETDAALDAARLDELPAATGLLRLLDVSWEIADRYPGLRHAEPPPADRRQEDEQHRPITDRLERIARRGQESGEFARDAEPHWLAAATVALGHAAGAEVAAGRMTPAAAAEALRVGVLRLHGAEAEAEAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2S3</accession>
    <name>A0A0F7N2S3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_12450</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016245.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_12450"/>
    <dbReference type="EnsemblBacteria" id="AKH82910">
        <property type="protein sequence ID" value="AKH82910"/>
        <property type="gene ID" value="AA958_12450"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_12450"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2616"/>
    <dbReference type="OrthoDB" id="1859755at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13577">
        <property type="entry name" value="SnoaL_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="SnoaL-like" evidence="3">
        <location>
            <begin position="152"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH82910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="227" mass="23503" checksum="4A9B6D383FC2A945" modified="2015-07-22" version="1">MSRDGERESTAGVVVDAREREPAESADTAEAEAAEAGIAEAEAAEAGSGDSGGEGRTGSAAARRRLRAAGVAVLVALLLAGTGLLVQAARLNGDDALANRALTDSSGTAAVAGDVSNALSKVFSYAPEDPGVTARDADDLLAGPAREQYRQLFGQIRQRVVAQELTLTTHVVRAGVIRLDGDDATLLVLLDQITERKGKDPATAGAQLSVTAERQDGQWRITDLKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N301</accession>
    <name>A0A0F7N301_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Exopolyphosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_13150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016352.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_13150"/>
    <dbReference type="EnsemblBacteria" id="AKH83020">
        <property type="protein sequence ID" value="AKH83020"/>
        <property type="gene ID" value="AA958_13150"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_13150"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2767"/>
    <dbReference type="OrthoDB" id="361195at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010839">
        <property type="entry name" value="AtuA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07287">
        <property type="entry name" value="AtuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="428"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="434"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="571" mass="59201" checksum="90456AEBD0F5C82E" modified="2015-07-22" version="1">MTLRIGNASGFYGDRFAAVREMLTGGELDVLTGDYLAELTMLILARDRLKDPGAGYARTFLRQLEDGLGLARDRGVTLVVNAGGLNPAGLAAAVRELAGRVGVPARVAHVEGDDLTARGTWPGALAAHAYLGGAGIAACLRAGADVVVTGRVTDAALVTGAAQAHYGWTPAAADDPDDPGAADDPALHALAGAVVAGHVLECGTQATGGNYAFFTEHDVRHPGFPLAEIEPDGSAVITKHPGTGGAVTVGTVTAQLLYETAGPRYAGPDVTARLDSVRLAQDGPDRVRITGVRGEPPPPDLKVGLSRLGGHRNEVVFVLTGLDIDAKAALVRDQMAPALKGVADVRWTLARTDRPDAGVQEEASALLRLAVRDPDEAAVGRAVSGAAVELALASIPGFHVTAPPGRAQPYGVFEAAYVPAADVPHTAVLPDGTRVPVAPPPRTRALEPVPEPPLPPPPPPGPTRRAPLGTVAGARSGDKGGSANLGVWARSGAAWPWLAHTLTVDRFRELLPETAPFPVVRHVLPHLRALNFTVEGLLGEGVASQARFDPQAKALGEWLRARHADIPEELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N358</accession>
    <name>A0A0F7N358_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Methylated-DNA--protein-cysteine methyltransferase</fullName>
            <ecNumber evidence="7">2.1.1.63</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">6-O-methylguanine-DNA methyltransferase</fullName>
            <shortName evidence="7">MGMT</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">O-6-methylguanine-DNA-alkyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AA958_05795</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>a 4-O-methyl-thymidine in DNA + L-cysteinyl-[protein] = a thymidine in DNA + S-methyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:53428"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:13555"/>
            <dbReference type="Rhea" id="RHEA-COMP:13556"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:137386"/>
            <dbReference type="ChEBI" id="CHEBI:137387"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 7">
            <text>a 6-O-methyl-2'-deoxyguanosine in DNA + L-cysteinyl-[protein] = a 2'-deoxyguanosine in DNA + S-methyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:24000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:11367"/>
            <dbReference type="Rhea" id="RHEA-COMP:11368"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:85445"/>
            <dbReference type="ChEBI" id="CHEBI:85448"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="7">This enzyme catalyzes only one turnover and therefore is not strictly catalytic. According to one definition, an enzyme is a biocatalyst that acts repeatedly and over many reaction cycles.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the MGMT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.63" evidence="7"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015146.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_05795"/>
    <dbReference type="EnsemblBacteria" id="AKH81793">
        <property type="protein sequence ID" value="AKH81793"/>
        <property type="gene ID" value="AA958_05795"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_05795"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1213"/>
    <dbReference type="OrthoDB" id="1327994at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003908">
        <property type="term" value="F:methylated-DNA-[protein]-cysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA dealkylation involved in DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06445">
        <property type="entry name" value="ATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00772">
        <property type="entry name" value="OGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001497">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014048">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036217">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNAb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008332">
        <property type="entry name" value="MethylG_MeTrfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023546">
        <property type="entry name" value="MGMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036631">
        <property type="entry name" value="MGMT_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01035">
        <property type="entry name" value="DNA_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02870">
        <property type="entry name" value="Methyltransf_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46767">
        <property type="entry name" value="SSF46767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53155">
        <property type="entry name" value="SSF53155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00589">
        <property type="entry name" value="ogt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00374">
        <property type="entry name" value="MGMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 7 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_1N" evidence="9">
        <location>
            <begin position="14"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="DNA_binding_1" evidence="8">
        <location>
            <begin position="89"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; methyl group acceptor" evidence="7">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AKH81793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="175" mass="18248" checksum="082BE5D4D562E945" modified="2015-07-22" version="1">MDATDAIAPRQGRRVVDSPIGPLLLAATDRGLVKVGFHAEPGAAGPAGREEPAGPAAHIAAAERQLREYFAGGLKEFRLELDWSLSDGFNRRVLEELAAEVPFGSVVSYQFLAGRVGEPGAAQAVGRAMASNPLPIVVPCHRVIESDGGLGGFGGGLDTKRSLLALEGVLPEPLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N379</accession>
    <name>A0A0F7N379_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sulfur reduction protein DsrE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_13655</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016435.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_13655"/>
    <dbReference type="EnsemblBacteria" id="AKH83105">
        <property type="protein sequence ID" value="AKH83105"/>
        <property type="gene ID" value="AA958_13655"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_13655"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2874"/>
    <dbReference type="OrthoDB" id="1997912at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027396">
        <property type="entry name" value="DsrEFH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003787">
        <property type="entry name" value="Sulphur_relay_DsrE/F-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02635">
        <property type="entry name" value="DrsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75169">
        <property type="entry name" value="SSF75169"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH83105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="120" mass="12472" checksum="30A1F3F05C6760C9" modified="2015-07-22" version="1">MAKKLVIKVTAGTDAPERCSQAFTVAAVAAASGVEVSLWLTGESAWFALPGRAAEFELPHAAPLPELIDGVLASGRITLCTQCAARRGIEEKDVLEGVRIAGAQVFVSEAMADGSQALVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N387</accession>
    <name>A0A0F7N387_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Branched-chain amino acid ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_05965</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015176.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_05965"/>
    <dbReference type="EnsemblBacteria" id="AKH81823">
        <property type="protein sequence ID" value="AKH81823"/>
        <property type="gene ID" value="AA958_05965"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_05965"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1247"/>
    <dbReference type="OrthoDB" id="776281at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028081">
        <property type="entry name" value="Leu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13458">
        <property type="entry name" value="Peripla_BP_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519122" evidence="1">
        <location>
            <begin position="18"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_6" evidence="2">
        <location>
            <begin position="40"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH81823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="413" mass="43549" checksum="167B41C326E17B6B" modified="2015-07-22" version="1">MRHRSLLILTTAVTAGALTLSACGSRDDDSEGGGGGDGTTVVIGLDAPLTGDLSALGIGIQNSAELAVKTANKNEEVKGVTFELEPLDDVAQAQQGQQNATKLVGNEDVMGVVGPLNSDVGQSMQKVFADADLVQVSPANTNPALTQGEEWQDGEKTRPFDTYFRVSTTDAIQGPYAAQYLYNEEKLQKVFVIDDKKTYGAGLAGTFADEFEKLGGKVVGTDHVNPDDKDFAAIATKVKNSGADFVYYGGEYPAGAPLAAQVKKAGAKIPTVGGDALFSAEYVALAKENAEGDMASSVGAPLTELDTAKEFIKNYEAAGYEDAYEAYGGYSYDSTWAIIQAVKTVVEENDGELPGDTDEARKAITEAMNDVSFEGVTGKVGFDEFGDTTNKQLSLYQVKDGEHVPLTSGEFEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3Q3</accession>
    <name>A0A0F7N3Q3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sec-independent protein translocase protein TatA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">tatA</name>
        <name evidence="9" type="ORF">AA958_03950</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TatA/E family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014839.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_03950"/>
    <dbReference type="EnsemblBacteria" id="AKH81482">
        <property type="protein sequence ID" value="AKH81482"/>
        <property type="gene ID" value="AA958_03950"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_03950"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.829"/>
    <dbReference type="OrthoDB" id="1907955at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033281">
        <property type="term" value="C:TAT protein transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043953">
        <property type="term" value="P:protein transport by the Tat complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00236">
        <property type="entry name" value="TatA_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003369">
        <property type="entry name" value="TatA/B/E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006312">
        <property type="entry name" value="TatA/E"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02416">
        <property type="entry name" value="TatA_B_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01411">
        <property type="entry name" value="tatAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="44"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="72"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH81482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="102" mass="10929" checksum="9EDB701D1109069E" modified="2015-07-22" version="1">MFGRLGPTEIILILVVVILLFGAKKLPDMARSLGKSARILKSEAKAMKNEGKTDEAAPADPPQPAPKTIQAAPGDVTSSRPVSEPQVNDQQPQAQTQQQSQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3R6</accession>
    <name>A0A0F7N3R6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HATPase_c domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_06905</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015339.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_06905"/>
    <dbReference type="EnsemblBacteria" id="AKH81988">
        <property type="protein sequence ID" value="AKH81988"/>
        <property type="gene ID" value="AA958_06905"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_06905"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1443"/>
    <dbReference type="OrthoDB" id="1687028at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="97"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="120"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="4">
        <location>
            <begin position="321"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="361"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="447"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="169"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="377"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH81988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="493" mass="51355" checksum="C9B308F3BA588C60" modified="2015-07-22" version="1">MTSLAALPRWLRAHPLAADALLAAVALAAILISSVYPDRGANAPPPADLGAAEVVLATAACAVLVLRRRAPWAVLAATMTLTIAHVIASAGDPRSPIALSVVVALYTVAARTDRHTTWRIALLTIGVLTFAMMLFGDRPWYADENLGVFAWTGMAAGVGDAVRSRRAVVDAIRERAERAERTREEEARRRVAEERVRIARELHDVVAHHIALVNVQAGVASHVMESRPDQAKEALAHVRDAGRTALEELRTTVGLLRQSGDPHAPTEPSPGLAMLAELVEGFVRAGTPVSVEVASELGPRRTAVTTRVERAAEVVGGLPAAVDLAAYRVLQEALTNVHKHAGAEAHAVVSLSREADELEIAVRDDGPGTAGTGPDDGRDGGGKDGARRDGGAKDGAEGDADGERAGGLGLVGMRERAAALGGRCTAGERTDGRTGFEVRVRLPLRVAADADTGGTPAAGGPGTARPPREREANGTRASGCLRRASGGAIKEQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3Z2</accession>
    <name>A0A0F7N3Z2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_07455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015443.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH82093">
        <property type="protein sequence ID" value="AKH82093"/>
        <property type="gene ID" value="AA958_07455"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_07455"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="81" mass="9011" checksum="569E73446B67F6E6" modified="2015-07-22" version="1">MQTDEHATDSGSGGSDESRRRRAETGRRGEPARPAESRDAYDDEQDEAIDADPQLREIGRARLRKRTDRASRGEQGGGARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N424</accession>
    <name>A0A0F7N424_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AA958_04625</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014952.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH81597">
        <property type="protein sequence ID" value="AKH81597"/>
        <property type="gene ID" value="AA958_04625"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_04625"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.975"/>
    <dbReference type="OrthoDB" id="1891092at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="103"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="134"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="9">
        <location>
            <begin position="10"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AKH81597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="265" mass="27632" checksum="22209EC71AE41626" modified="2015-07-22" version="1">MSDLAYDGMAIVGRQLQRARRNPALLVTTQVMPLTLLLFFGYVFGNSVSLPGDADYRTYIVPGLFATTAAGGLVTGMLQAAVDTGRGVTERFRALPISRAAVPLGHAVADVLLFAAGLVPLVAVGYAVGWRNDGSAAATAGALGLLLLLRFTSAWIGIHLGMAVGNEEAAGQLASTTFMLQLLSNAYVPTHGMPGWLRAVVEWNPLSAYVTAVRDLTGSAPPGLDDAPGAAWPMTHPVAAALVWSVVLLAVFVPLAVRRSARGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4B1</accession>
    <name>A0A0F7N4B1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNA polymerase sigma factor SigM</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_16145</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016793.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_16145"/>
    <dbReference type="EnsemblBacteria" id="AKH83485">
        <property type="protein sequence ID" value="AKH83485"/>
        <property type="gene ID" value="AA958_16145"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_16145"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3402"/>
    <dbReference type="OrthoDB" id="1914729at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="31"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="7">
        <location>
            <begin position="130"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="105"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="194"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH83485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="228" mass="24473" checksum="CD2928112551BBE3" modified="2015-07-22" version="1">MENASGGDVDDRTLLARHVSGEDPYAFAEIVRRHRDRLWAVALRTLGDREEAADAVQDALLSAFRAAHTFRGQSAVTTWLHRITVNACLDRARKAASRRAAPVADTEHFEQLLEPEESAEAPAEREDTGRELREALATLPVEQRAALVLVDMAGYPVAEAADILGVPAGTVKSRCARGRARLLPLVRHLRLSAADSGAGGRNPAQGTSVPPTAEQHDVRAAKGGGEKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N527</accession>
    <name>A0A0F7N527_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">D-aminoacyl-tRNA deacylase</fullName>
            <shortName evidence="1">DTD</shortName>
            <ecNumber evidence="1">3.1.1.96</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Gly-tRNA(Ala) deacylase</fullName>
            <ecNumber evidence="1">3.1.1.-</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">dtd</name>
        <name evidence="2" type="ORF">AA958_13695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a D-aminoacyl-tRNA + H2O = a D-alpha-amino acid + a tRNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13953"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:10124"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59871"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:79333"/>
            <dbReference type="EC" id="3.1.1.96"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>glycyl-tRNA(Ala) + H2O = glycine + H(+) + tRNA(Ala)</text>
            <dbReference type="Rhea" id="RHEA:53744"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:13640"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78522"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DTD family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.96" evidence="1"/>
    <dbReference type="EC" id="3.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016441.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_13695"/>
    <dbReference type="EnsemblBacteria" id="AKH83111">
        <property type="protein sequence ID" value="AKH83111"/>
        <property type="gene ID" value="AA958_13695"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_13695"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2882"/>
    <dbReference type="OrthoDB" id="1862614at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051499">
        <property type="term" value="F:D-aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106026">
        <property type="term" value="F:Gly-tRNA(Ala) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043908">
        <property type="term" value="F:Ser(Gly)-tRNA(Ala) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019478">
        <property type="term" value="P:D-amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00518">
        <property type="entry name" value="Deacylase_Dtd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003732">
        <property type="entry name" value="Daa-tRNA_deacyls_DTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023509">
        <property type="entry name" value="DTD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10472">
        <property type="entry name" value="PTHR10472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02580">
        <property type="entry name" value="Tyr_Deacylase"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00256">
        <property type="entry name" value="TIGR00256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0820">tRNA-binding</keyword>
    <feature type="short sequence motif" description="Gly-cisPro motif, important for rejection of L-amino acids" evidence="1">
        <location>
            <begin position="133"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="141" mass="14994" checksum="E533D943384DF721" modified="2015-07-22" version="1">MRAVVQRVDGARVEAGGETVGEVIGEGLCVLVGVTHDDTPAKAAQLARKLWTLRVLDDEKSCSDVSAPLLVISQFTLYGDPRKGRRPTWQAAAPGEVAEPLVEEVVARLRALGAQVETGAFGAKMRVTLTNDGPFTVLVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5C0</accession>
    <name>A0A0F7N5C0_9ACTN</name>
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        <submittedName>
            <fullName evidence="4">Histidine kinase</fullName>
        </submittedName>
    </protein>
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        <name evidence="4" type="ORF">AA958_10545</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_10545"/>
    <dbReference type="EnsemblBacteria" id="AKH82589">
        <property type="protein sequence ID" value="AKH82589"/>
        <property type="gene ID" value="AA958_10545"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_10545"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2220"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <begin position="185"/>
            <end position="325"/>
        </location>
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        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="589" mass="63239" checksum="C0E02DD30DAAED7C" modified="2015-07-22" version="1">MDDFRAAFDGAQLAMAVVGGDGLVRAANSRMQELVGAGESGLAGASAAELTGLRDEPWSWAGFVDVLQGRRASLRCTRRMKDAGGRSLSVEMTLTPLSGGRALLSLSDVTEQRELRAKLRHLKMHDPVTRLPNRELFFERLTGALQEARQEEEPAAEHGGAGRGRGQGGSRTRTRAAAPAPGAAGRVGLAYLDLDGFKAVNDTLGHRVGDRLLAAVARRLVACTAEAGKAEKHGITVARLGGDEFAVLVARSAGTEQLGELAQRLLDALQEPFDLAGQRLAVSASIGVVERAASGQTATALMQAADTTLYWAKADGKARWTLFDPERNAHRMTRQALSSTLRPAIERDEFTLDYQPLIDLGDGSVRGVEALVRWQHPKLGTLTPNRFIGLAEENGAIVPLGRWVLATACRRAAGWRRLRPADPVFVSVNVAVRQVWDSDLVADVAQILEETGLPPRLLQLELTESAVMGSAGRPLQALQELSEMGVGIAIDDFGTGYSNLAYLSRLPVSALKLDGSFVRGFSSAEHPSPADETIVEALVDLAHRLGISVTAECVESGEQAERLRRIGCDTAQGWFYSRAVPAERVERLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5C4</accession>
    <name>A0A0F7N5C4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">AA958_10570</name>
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    <organism evidence="1 2">
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        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82594.1"/>
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    </dbReference>
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AKH82594">
        <property type="protein sequence ID" value="AKH82594"/>
        <property type="gene ID" value="AA958_10570"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_10570"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2225"/>
    <dbReference type="OrthoDB" id="1867583at2"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="DUF3830"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12903">
        <property type="entry name" value="DUF3830"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="SSF50891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH82594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="166" mass="18084" checksum="A75CDA3589847639" modified="2015-07-22" version="1">MSARFVEVSLAKRGVRCTAKLLDDRAPMTCAAVWNALPLGGDVYHAKYARNEIYTLLPAFAPAEPPLENPTVTPIPGDLCYFSFTDTVLGTASYGYEAEAKHQGRASVVDLALFYERNNLLINGDSGWVPGIVWGSIVEGLDEMAAACQDLWRAGALGETLNFRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5D4</accession>
    <name>A0A0F7N5D4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_07060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015367.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH82017">
        <property type="protein sequence ID" value="AKH82017"/>
        <property type="gene ID" value="AA958_07060"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_07060"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1479"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH82017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="64" mass="6941" checksum="283F69D26409A074" modified="2015-07-22" version="1">MLLWPLGGGSLYFTYTELRRTLTEGSGTYATHDDRTRETAELVTRIAGPAADRTGGRSGHADGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5K4</accession>
    <name>A0A0F7N5K4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_11055</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016016.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_11055"/>
    <dbReference type="EnsemblBacteria" id="AKH82678">
        <property type="protein sequence ID" value="AKH82678"/>
        <property type="gene ID" value="AA958_11055"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_11055"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2328"/>
    <dbReference type="OrthoDB" id="1584669at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="180"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="68"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH82678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="273" mass="29952" checksum="75E86917552210D6" modified="2015-07-22" version="1">MSPVKKYPVLVALVLGAAFMVLPFFIVLMNAVKTPEEYSSDGPLSMPDGVYLDGLADFWERVDFGQKLWNSVLISGSVALLAVVLSVLSAYAIGIGRIRGRPYVLAFFVLANMLPQEALVYPIYYLSKEFGLYDTRLSVVIVFTVVQSAFGTYLLSSVLGGFPREVIEAARIDGATKWQVLWRVVVPVSRPTIGVLMVLFFIWTWNEFLLPLVMLVSDDNQTVSVALGVLQGQRDMDATMTNAAALLGVLPAIAFFLIFQRTLTRGIAVGAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5M8</accession>
    <name>A0A0F7N5M8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Gmad1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_11295</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_11295"/>
    <dbReference type="EnsemblBacteria" id="AKH82719">
        <property type="protein sequence ID" value="AKH82719"/>
        <property type="gene ID" value="AA958_11295"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_11295"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2380"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018910">
        <property type="entry name" value="Lipoprotein_LpqB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10647">
        <property type="entry name" value="Gmad1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gmad1" evidence="2">
        <location>
            <begin position="371"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH82719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="624" mass="66087" checksum="E3AE24CB8A72618B" modified="2015-07-22" version="1">MAVRGRGRRTAARAAGAYRRRLPARTRRYATVALLGGSLLLAGCASMPDSGGVHQVPLSEQREDPRARTYAERPEPGASPQRIVSDFLEALRSDDYATVAKAYLTKKARTWTPGETTVLAEAPRVSEQPTPGPKPVNGDRMTTAVVQLSGDKVAWLNDAGTYTPDERVYNLNIELSKEGKSGQWRIVDPPRGLVISRADFERTFQSASTYHFTARSRDTLVADPVYVRRRIDPVTDAVRTLLDGPGGLIGSVTETTFPERTTLARNQRLAVDEEGTLRVRLALETTPGLHTCERMAAQVLHTAESQEGVRVDNVELLTARDTKLCDLSATAGERYAPDRLARHPSSLYFIDAKNRLVRTSSGPDAGEAGPATVISPLGDGKPAIGSAAVARSEKKAAGVTATGRALYVSSLDESSALGEPLLTSGATEAQAERGDGLTAASWDGLGDLWVADRVGGESRLYWMAGGAADPVRIDVTGLEGRIEALRMSAEGARIALVVSEGSESRLVLGAVSVKDGVPVVAQLRDTGALEEVRAVSWAGESRLLVVGRESEGVQQMRLVSTDGSVPPAAELGQGLTGVTSVAAAEDGTKPLVAAVEDGIVRLPQNAYWKAVPGGEGGTAPVYPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5S3</accession>
    <name>A0A0F7N5S3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Relaxase/mobilization nuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_18895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017217.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_18895"/>
    <dbReference type="EnsemblBacteria" id="AKH83920">
        <property type="protein sequence ID" value="AKH83920"/>
        <property type="gene ID" value="AA958_18895"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_18895"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3966"/>
    <dbReference type="OrthoDB" id="1222566at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="283" mass="31479" checksum="3E0738AFA9CAF5B4" modified="2015-07-22" version="1">MIPRVHQRTHTAIEPFTQALGRPVSPEDGLNEHTVVAYWPGLDDSTHDDEQRTWTSAQWAEHLEDPYADHPYAASRYGDRHAIFHFEITLAREDRTLTGPEWAEVAHRFARAAGIEIPGSPQARECRWVALQARPGRLDLIANLIRHGGAWYNPPADTERRLADEARRIEADLRLIPVYDTPRTRAGNRPVPTAQKQLAAVLTQLADEQSGPLAAVRGLVEHTAQRITRQPTAAGTGTAHRLELIARRIHALQLDLDATAHDMTQSAAATTPTAVRPAAHRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N662</accession>
    <name>A0A0F7N662_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GFO_IDH_MocA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_08905</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_08905"/>
    <dbReference type="EnsemblBacteria" id="AKH82327">
        <property type="protein sequence ID" value="AKH82327"/>
        <property type="gene ID" value="AA958_08905"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_08905"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1875"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="6"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="340" mass="36457" checksum="8F2AEA4F310AF9EF" modified="2015-07-22" version="1">MLRTFIVGLGRSGRELHLPVLLRLRRRFPDLFSASPPLGYDTGPAGGPDDDAEIETVGSLAAARLRLDPAATLVHVCTPPGERAGVLAALGELGFVNVLVEKPLADTAEALAELAAVREKYGLRMAVVAPWLHSTLTERLADLVESGRFGPLRHIGIRQHKPRIHRTLNSAGHRTAFDVEPPHAVGVALRLAGDADVTGAALTDVDVGGRRVPGMGGAELTLRHHSGVVSRLECDLTSPRRERRIELDFASGRVVGHYPVGSEDHYAHLTASPVDGPPAESVFPDLALDACLLDAYRHLAGDDPDEAVLDARVRRQMQVVRLLDAAKHMSGSRTEARDAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N688</accession>
    <name>A0A0F7N688_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNA polymerase subunit sigma-24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_16840</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Interacts transiently with the RNA polymerase catalytic core formed by RpoA, RpoB, RpoC and RpoZ (2 alpha, 1 beta, 1 beta' and 1 omega subunit) to form the RNA polymerase holoenzyme that can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016905.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH83601">
        <property type="protein sequence ID" value="AKH83601"/>
        <property type="gene ID" value="AA958_16840"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_16840"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3543"/>
    <dbReference type="OrthoDB" id="1335404at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="13"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="7">
        <location>
            <begin position="110"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH83601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="293" mass="31394" checksum="DD9111BAE9734AB6" modified="2015-07-22" version="1">MEATRALSDADWRAHRPAVFGAAYRILGSVAEAEDVTQDVWLRAAEADLAQVRDLRAWLVTVAARTSYNVLQSARVRREAYVGPWLPEPLPTGPDAAAQVLVDESVGTAMLVLMERLTPAERVAFVLHDVFGFPFARVADVLGATPAAARKLASRARARVRADGRRPDASRAETERVLRAFKAAAEAGDMAGLVALLHPDAVYVGDGGGKATAARRPVRGAETIALLAVRSVRIARPDAVRLVEVNGQPALATYRDGRPVWLDTVEVADGRLTAIRRLANPDKLGPVAALGHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6A8</accession>
    <name>A0A0F7N6A8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AA958_12690</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016273.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_12690"/>
    <dbReference type="EnsemblBacteria" id="AKH82938">
        <property type="protein sequence ID" value="AKH82938"/>
        <property type="gene ID" value="AA958_12690"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_12690"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2667"/>
    <dbReference type="OrthoDB" id="643917at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="158"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="237"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="21"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="330"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="362"/>
            <end position="369"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AKH82938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="573" mass="60824" checksum="64A96421542758F7" modified="2015-07-22" version="1">MIRTLLRVLGHQHARPLRRTVALMLATAVVEGLSYALLVPVLRALFGSSPEDAWPWLIAFAAVFALYGALRFTSDLAGFRVGVELLRGLYHRLGDHLARLPVGWYGAGRVGEVSALAGQGVLQAMSVIAHLLAPSLSAAVTPLTIVAVMLVFNWQLGLAALAAVPVVAAVQVWTSRSMAAADEERAARDHEAAGRVVEYLQAQPVLRAGGRSAERFRLLDDSLHAVQRASRRTTLSVLPGALGLTLTVQALFTTLLALGAYLALEGDIGAAEVLATLVLAARCADPLLSLSDVAGKFRAARTVVTKLDTVLRTEPLPEAADPVEPAGHRLEFDAVTFRHGDRTVLDGVSLTVAEGERLAVVGPSGAGKSTLLHLLTRFHDVDAGAVRVGGQDVRAISTETLMSKIAIVFQHVYLFAGTIEDNVRLGRPDATAAEVRAAATAARLDEVIDRLPGGWATDVGEGGTALSGGERQRVAIARALLKDAPVVLLDEVTSALDPVNEAAVHQGIERLMAGRTVVIVAHRMRTVRRADRIVFLDAGRITEEGTHDTLLSRNGPYTAFHHATHTPAPTTAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6Q9</accession>
    <name>A0A0F7N6Q9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Mechanosensitive ion channel protein MscS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AA958_09855</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MscS (TC 1.A.23) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015829.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_09855"/>
    <dbReference type="EnsemblBacteria" id="AKH82487">
        <property type="protein sequence ID" value="AKH82487"/>
        <property type="gene ID" value="AA958_09855"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_09855"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2076"/>
    <dbReference type="OrthoDB" id="1903165at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011066">
        <property type="entry name" value="MscS_channel_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011014">
        <property type="entry name" value="MscS_channel_TM-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045276">
        <property type="entry name" value="YbiO_bact"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30460">
        <property type="entry name" value="PTHR30460"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82689">
        <property type="entry name" value="SSF82689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82861">
        <property type="entry name" value="SSF82861"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH82487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="336" mass="35553" checksum="4B5C9BE01B5FDA2E" modified="2015-07-22" version="1">MFATARPAAESPSPTPLEDSRKSAEETAGWIQENWASWLGVGLRILLVVVIAYVLRRVVQRMITKLITRMTRTADAVDGTALGGLLVNHERRRQRSEALGSILRSSASFVILGTAALTVLSALKIDLAPLLASAGVAGVALGFGARNLVMDFLSGVFMLIEDQYGVGDTIDVGEVTGEVVEVGLRVTKLRGDNGAIWYMRNGEVKRIGNLSQGWATAVVDVPVAAAEDLDRVRDVIAAAGEEFGVTEPWSEQLWGEVDVLGLTAVAQGTAVIQVQVRTMPGKSVGVERELRWRIREALLAAGVVMSDVPPGAIVPPRAEQVAVVQQAPSGGGGGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6R3</accession>
    <name>A0A0F7N6R3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_09880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH82492">
        <property type="protein sequence ID" value="AKH82492"/>
        <property type="gene ID" value="AA958_09880"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_09880"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="109" mass="11976" checksum="5503352B23743863" modified="2015-07-22" version="1">MPREATADVRELFTETERPVDSPVSARDSRPDTDRRDARELLRDVLLDRLDALEPLDEELPLLPRRCPVTPVGAEPTTPSGETTGASPQVSQYSSPPPTSSYVPPQPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6S7</accession>
    <name>A0A0F7N6S7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3-carboxy-cis,cis-muconate cycloisomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_10045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015854.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_10045"/>
    <dbReference type="EnsemblBacteria" id="AKH82512">
        <property type="protein sequence ID" value="AKH82512"/>
        <property type="gene ID" value="AA958_10045"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_10045"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2115"/>
    <dbReference type="OrthoDB" id="347727at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016840">
        <property type="term" value="F:carbon-nitrogen lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019468">
        <property type="entry name" value="AdenyloSucc_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10397">
        <property type="entry name" value="ADSL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00998">
        <property type="entry name" value="ADSL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADSL_C" evidence="1">
        <location>
            <begin position="381"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="463" mass="47277" checksum="B52E3F86E7909B93" modified="2015-07-22" version="1">MTTDLDAGLLSPVRAGTPVEAAVSDRAWLQAMLDAEAALARAQARTGTMPATAAAAITAAARAELLDLRALACAARETANPVVGLVKALSGVVAERDPAAAEYVHRGSTSQDVFDTGAMLVCDRALRLVHADLLRTAGALAELAAGHRDTLMAGRTLTLHAVPTTFGLKAAGWRALVLDAAARLERVLAGGLPVALGGAAGTLAGYLEYAALDGAGAEDSGAYVERLTAAFADETGLAPATLPWHVLRTPIADVAAVTAVVAGALGKIAVDVQSLGRTEVAEVAEPAVAGRGGSSAMPHKRNPVLATLIRSASLQVPALAAAVTQCMVTEDERSAGAWHAEWHLLRECLRLAGGAAHTAVELAEGLQVRPERMRANMRLTENLVTSERVAAVLAPLLGKARAKELLTDAAAESERTGAGMPGLLAAVPAIAEHFDEPALAALLDPASYTGAAGPLVDRALADS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N710</accession>
    <name>A0A0F7N710_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribonuclease PH</fullName>
            <shortName evidence="4">RNase PH</shortName>
            <ecNumber evidence="4">2.7.7.56</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">tRNA nucleotidyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 7" type="primary">rph</name>
        <name evidence="7" type="ORF">AA958_10710</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>phosphate + tRNA(n+1) = a ribonucleoside 5'-diphosphate + tRNA(n)</text>
            <dbReference type="Rhea" id="RHEA:10628"/>
            <dbReference type="Rhea" id="RHEA-COMP:17343"/>
            <dbReference type="Rhea" id="RHEA-COMP:17344"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:173114"/>
            <dbReference type="EC" id="2.7.7.56"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homohexameric ring arranged as a trimer of dimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RNase PH family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.56" evidence="4"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015958.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_10710"/>
    <dbReference type="EnsemblBacteria" id="AKH82617">
        <property type="protein sequence ID" value="AKH82617"/>
        <property type="gene ID" value="AA958_10710"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_10710"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2253"/>
    <dbReference type="OrthoDB" id="1824064at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-exoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009022">
        <property type="term" value="F:tRNA nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11362">
        <property type="entry name" value="RNase_PH_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00564">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002381">
        <property type="entry name" value="RNase_PH_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018336">
        <property type="entry name" value="RNase_PH_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="SSF55666"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01966">
        <property type="entry name" value="RNasePH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01277">
        <property type="entry name" value="RIBONUCLEASE_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 4" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 4" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="2 4" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="RNase_PH" evidence="5">
        <location>
            <begin position="20"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="RNase_PH_C" evidence="6">
        <location>
            <begin position="170"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphate (substrate) binding" evidence="4">
        <location>
            <begin position="134"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <note>substrate</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH82617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="252" mass="26627" checksum="AF9FA3D1051A3829" modified="2015-07-22" version="1">MATSETSAGFGRIDGRTPAELRPVALERGWSMHAEGSVLVSFGGTRVLCTASFTEGVPRWRKGSGEGWVTAEYAMLPRSTNTRGDRESVRGKIGGRTHEISRLIGRSLRAVIDFKALGENTVVLDCDVLQADGGTRTAAITGAYVALADAVAWGRRNKLIKSRATPLTGTVAAVSVGIVGSVPLLDLCYEEDVRAETDMNVVCTGDGRFVEVQGTAEGEPFARAELDALLDLAVGGCAQLDGLQRTALEGDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N739</accession>
    <name>A0A0F7N739_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DEAD/DEAH box helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_14325</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016529.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_14325"/>
    <dbReference type="EnsemblBacteria" id="AKH83213">
        <property type="protein sequence ID" value="AKH83213"/>
        <property type="gene ID" value="AA958_14325"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_14325"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3015"/>
    <dbReference type="OrthoDB" id="35275at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022307">
        <property type="entry name" value="Helicase_put_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018973">
        <property type="entry name" value="MZB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09369">
        <property type="entry name" value="DUF1998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03817">
        <property type="entry name" value="DECH_helic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="128"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="3">
        <location>
            <begin position="355"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="843"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH83213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="862" mass="90914" checksum="2C854DD34665A071" modified="2015-07-22" version="1">MDANEWRDANGPGTAPAAAGIRPGRVPGARPGAPHVTPAGPPDGAPPGTPDRTAADGAVAGPARVTPRTALRRLAAREDRAARITHTEHLPPRGGHHADWPAGIRPEVVGAIEAAGIRRPWAHQARMAAHALAGESVIAATGTASGKSLAYLAPVLSAALDGSEAPNGRGATALYVAPTKALAADQLRAVKALAAPLGKAVRPAVYDGDTPTEEREWVRLYANLVLTNPDMLHRGILPAHSRWSSFLRALRYIVIDECHTYRGVFGSHVAQVVRRLRRLCARYGADPVFLLASATAAEPGRSAERLTGRAVAEVTDDASPRGEVAFALWEPPLTELHGERGAPVRRTATAECAELLTDLAVADVRTVAFVRSRRGAELVAMIAQDRLAAVDRALADRVAAYRGGYLADERRALEAALQSGELLGLAATSALELGVDVSGLDAVLIAGYPGTRASLWQQAGRAGRSGQGALAVLVARDDPLDTYLVHHPEALFRRPVESTVLDPDNPYVLAPHLCAAAAELPLTDADFTGDSACFGAGAAGLLPQLADRGLLRRRGTGPGAAWHWTRRERACDLTDIRGGGGRPVDVVEDGTGRLLGTVDAAASHTTVHEGAVHLHQGRTYVVRTLDLEDNVALVERADPPYTTVARDTTSVSVLETEREIPWGDARLCFGSVEVTNHVVSFLRRRLITGEIMGETKLDLPPRTLRTRAVWWTVTDDQLDAADIAQEQLGGALHAAEHAAIGMLPLFATCDRWDIGGVSVPLHGDTLLPTVFVYDGHSGGAGFAERAFGVARDWLGATRAAIAACECESGCPSCVQSPKCGNGNDPLDKAAAVRLLTTLLREAGQRAEPAATPAAQREAANES</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7F5</accession>
    <name>A0A0F7N7F5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ArsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_15075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016634.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_15075"/>
    <dbReference type="EnsemblBacteria" id="AKH83319">
        <property type="protein sequence ID" value="AKH83319"/>
        <property type="gene ID" value="AA958_15075"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_15075"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3176"/>
    <dbReference type="OrthoDB" id="1772343at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="21"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="122" mass="13510" checksum="E9C9374D906C40E9" modified="2015-07-22" version="1">MPERDTAPSPTPAVHRHEWTPDREQLEAASTVFALLADATRLHLLWLLAEGEADVTELATASGAARPAVSQHLAKLRLAHLVHSRKEGRRVVYSLRDGHLRGLVIEALNHADHLMTGEPWHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7I5</accession>
    <name>A0A0F7N7I5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HxlR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_19505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017294.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH84001">
        <property type="protein sequence ID" value="AKH84001"/>
        <property type="gene ID" value="AA958_19505"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_19505"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4109"/>
    <dbReference type="OrthoDB" id="1919329at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="1">
        <location>
            <begin position="11"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="149" mass="16669" checksum="91117908564981CB" modified="2015-07-22" version="1">MQRTRFGEMACSIARTLDVIGEPWSPLILRDVWAGVHRFDHIQADLGISRKVLTERLNHLVGQGVLERLPYDARPRYEYHLTDKGADLVEMLMVMARWGDRWLAGEAGPPVLYRHHACGQIGHVDPRCSHCGEPMHAGDVDLLPGPGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7Q8</accession>
    <name>A0A0F7N7Q8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Succinyl-diaminopimelate desuccinylase</fullName>
            <ecNumber evidence="2">3.5.1.18</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_23250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.5.1.18" evidence="2"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017891.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_23250"/>
    <dbReference type="EnsemblBacteria" id="AKH84635">
        <property type="protein sequence ID" value="AKH84635"/>
        <property type="gene ID" value="AA958_23250"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_23250"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4901"/>
    <dbReference type="OrthoDB" id="906744at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009014">
        <property type="term" value="F:succinyl-diaminopimelate desuccinylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010174">
        <property type="entry name" value="Succinyl-DAP_deSuclase_DapE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01900">
        <property type="entry name" value="dapE-gram_pos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="1">
        <location>
            <begin position="168"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="357" mass="38133" checksum="A500DC194C37C1D9" modified="2015-07-22" version="1">MDLTLDAARLTAQLVDTASVSGDEKHLADAVEAALHRLPHLEVDRDGDAVVARTRLGRAERVVLAGHIDTVPVAGNLPSRLDGTYEDGVLWGCGTSDMKAGVAVQLRIAATVPAPNRDLTFVFYDNEEVDASRNGLRRLAERHPDWLAGDFAVLLEPSDGEIEGGCQGTLRAVLRTEGERAHSARSWLGANAIHAAAPALARLAAYEPRHAVIDGLEYREGLNAVRVSGGVAGNVVPDVCEVTVNFRYAPDRSEDEAIAFVREYFDGCGIAAITVEDSSPGALPGLAHPAAAAFTAAVGGVPRPKYGWTDVARFTALGVPAVNYGPGDPNYAHKRDEHVHTARIHHCEERLRAWLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8C7</accession>
    <name>A0A0F7N8C7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">50S ribosomal protein L6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rplF</name>
        <name evidence="7" type="ORF">AA958_21250</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 5">This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the universal ribosomal protein uL6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017573.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_21250"/>
    <dbReference type="EnsemblBacteria" id="AKH84301">
        <property type="protein sequence ID" value="AKH84301"/>
        <property type="gene ID" value="AA958_21250"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_21250"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4475"/>
    <dbReference type="OrthoDB" id="1398618at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.930.12">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01365_B">
        <property type="entry name" value="Ribosomal_L6_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000702">
        <property type="entry name" value="Ribosomal_L6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020040">
        <property type="entry name" value="Ribosomal_L6_a/b-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036789">
        <property type="entry name" value="Ribosomal_L6_a/b-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019906">
        <property type="entry name" value="Ribosomal_L6_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002358">
        <property type="entry name" value="Ribosomal_L6_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655">
        <property type="entry name" value="PTHR11655"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655:SF14">
        <property type="entry name" value="PTHR11655:SF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00347">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002162">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00059">
        <property type="entry name" value="RIBOSOMALL6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56053">
        <property type="entry name" value="SSF56053"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03654">
        <property type="entry name" value="L6_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00525">
        <property type="entry name" value="RIBOSOMAL_L6_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L6" evidence="6">
        <location>
            <begin position="11"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L6" evidence="6">
        <location>
            <begin position="92"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH84301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="179" mass="19271" checksum="C75370895766F7C1" modified="2015-07-22" version="1">MSRIGKLPIQVPAGVDVTIDGRTVNVKGPKGSLSHTVAAPIDVARGDDGTIVVSRPNDERKSRALHGLSRTLVANMVTGVTQGYVKKLEISGVGYRVQAKGSNLEFALGYSHPILIEAPEGITFKVENPTHFSVEGIDKQKVGEVAAKIRKLRKPDPYKAKGVKYEGEYIQRKVGKAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8J0</accession>
    <name>A0A0F7N8J0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphoribosylamine--glycine ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_17800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017056.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_17800"/>
    <dbReference type="EnsemblBacteria" id="AKH83754">
        <property type="protein sequence ID" value="AKH83754"/>
        <property type="gene ID" value="AA958_17800"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_17800"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3747"/>
    <dbReference type="OrthoDB" id="952734at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH83754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="483" mass="53014" checksum="85968A99D0D0E99C" modified="2015-07-22" version="1">MVHDSIRRWESGALAHAVSDPFAAGPLPWLHAGEESFEDGRLVPWYVDAATTGDGGVRLANDVLQQIKGFAAPSCAEPGESVDFRISVDPPQEFAVDIYRIGHYAGDGAAKVTSSPRLAGIVQPVPLAAGRTVSCHHWWLSWRLQIPSYFSPGAYVAVLTTADGHRSHAPFTVRSTEPADLLLLLPDVTWQAYNLYPEDGRTGASLYHAWDDEGCLLGEPEAATTVSFDRPYAGAGLPLHAGHAYDFIRWAERYGYDLAYADARDLHAGRVDPTRYRGIVFPGHDEYWSAPMRQAAEKARAAGTSLVFLSANTMYWQVGLAPSAAGEPDRLLHCTKRQGPGRPALWREQGAPEQELLGVQYVGRVPEPRPLVVRNADHWLWEATGALEGDELPGLVAGEADRYFPRAPLPQHTGRKLLAHSPYPDSRGMRRYQETSLYETPAGGLVFAAGTFAWSPALDRPDHVNSVIQRATANLLDRICKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8P9</accession>
    <name>A0A0F7N8P9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glucanase</fullName>
            <ecNumber evidence="7">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AA958_18545</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the glycosyl hydrolase family 6.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="7"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017170.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_18545"/>
    <dbReference type="EnsemblBacteria" id="AKH83873">
        <property type="protein sequence ID" value="AKH83873"/>
        <property type="gene ID" value="AA958_18545"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_18545"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3892"/>
    <dbReference type="OrthoDB" id="1331351at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016288">
        <property type="entry name" value="Beta_cellobiohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036434">
        <property type="entry name" value="Beta_cellobiohydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008965">
        <property type="entry name" value="CBM2/CBM3_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001956">
        <property type="entry name" value="CBM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036966">
        <property type="entry name" value="CBM3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001524">
        <property type="entry name" value="Glyco_hydro_6_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34876">
        <property type="entry name" value="PTHR34876"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00942">
        <property type="entry name" value="CBM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01341">
        <property type="entry name" value="Glyco_hydro_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00733">
        <property type="entry name" value="GLHYDRLASE6"/>
    </dbReference>
    <dbReference type="SMART" id="SM01067">
        <property type="entry name" value="CBM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49384">
        <property type="entry name" value="SSF49384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51989">
        <property type="entry name" value="SSF51989"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51172">
        <property type="entry name" value="CBM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00655">
        <property type="entry name" value="GLYCOSYL_HYDROL_F6_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2 7" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="4 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="9">
        <location>
            <begin position="443"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="domain" description="CBM3" evidence="10">
        <location>
            <begin position="531"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="360"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="369"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AKH83873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="681" mass="70664" checksum="05554395D6C918FF" modified="2015-07-22" version="1">MLTGTAAPAAGAAAARVDNPYAGATPYVNPQWAARATADGGEAIADQPTFVWMDRRAAIGGIGAAWGLERHLDEALDQGADLFQVVIYNLPGRDCSALASNGELKPEELGLYKSEYIDPIADILADPKYASLRIVTLIEPDSLPNMVTNAGGTDGSTDACVQMKQLGNYEKGVGYALSTLADIPNVYNYVDAAHHGWLGWDSNLAPAVDEFKKAATSEGATVSDVHGFIVNTANYSALHEPYFEVGGNVGSTPVRQAEWIDWNQYADELSYAQALRDLLVSRGGFDPGIGMLIDTSRNGWGGAARPTGPGPTTSVDAFVDGGRVDRRIHAGNWCNQSGAGLGERPVAAPESGIDAYVWAKPPGESDGSSRPIDNDEGKGFDRMCDPTYEGNPRNGNNPTGALADSPLAGHWFSAQFRQLVANAYPPVDGGGPGPGDDTQAPTVPTGLRVTGTTGASASLSWTASSDNVGVTAYDVFRDGTQVGSTAGTSFTDSGLRASTSYAYAVRARDAAGNASARTSTVTATTGSDGGGGGAVKVQYKNTDSAVTDNQIRMGLQLVNTGSTPVNLASVKVRYWFSGDSGATSFSTWCDWAVVGCGSVTHGVSASGSSAPGADRYLEVGFGSGTLAPGASTGEIQVRLAKSDWSAFNEADDYSRATNTGYADNPRVGVYSSGTLTWGTAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8T7</accession>
    <name>A0A0F7N8T7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP-dependent 6-phosphofructokinase</fullName>
            <shortName evidence="10">ATP-PFK</shortName>
            <shortName evidence="10">Phosphofructokinase</shortName>
            <ecNumber evidence="10">2.7.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Phosphohexokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">pfkA</name>
        <name evidence="12" type="ORF">AA958_25110</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + beta-D-fructose 6-phosphate = ADP + beta-D-fructose 1,6-bisphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer or homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.11" evidence="10"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018196.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_25110"/>
    <dbReference type="EnsemblBacteria" id="AKH84945">
        <property type="protein sequence ID" value="AKH84945"/>
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            <note>catalytic</note>
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        <source>
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        </source>
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    <sequence length="341" mass="36693" checksum="CADD630632D6DBF8" modified="2015-07-22" version="1">MRIGVLTAGGDCPGLNAVIRSVVHRAVAGHGDEVIGFEDGFKGLLEGRYSKLDLNAVSGILARGGTVLGSSRLERDRLREACENTEELSRELALDALIPIGGEGTLTASAMLADAGMPVVGVPKTIDNDISATDRTFGFDTAVGVATEAMDRLKTTAESHQRVMVVEVMGRHAGWIALESGMAGGAHGICLPERPFEIASLCKMVEERFDRHKKFAVICVAEGAHPAEGTMEYKKGEIDQYGHERFTGIGNRLAGELERRLGKEAKPVILGHVQRGGTPTAYDRVLATRFGWHAVEAVHRGDFGQMTALRGTDIVMAPLAEATRELKRVPAHRMDEAEVVF</sequence>
</entry>
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                <person name="Albersmeier A."/>
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                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9 10">CNQ-509</strain>
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    <sequence length="744" mass="76224" checksum="CD9219B0E19DE4D4" modified="2015-07-22" version="1">MSGLARWCLRRRLLVVLLWLAAFAGTAVAAALLGPAYSNDYDVPGTESGRVQVLMAEAFPGMDGVADSVVWHDDGGVGDAQTRERVDAALTEIAGLPGVSEVSGPYGSYAAGEAGAATGNGAGDGGAVSADGRTAYATVTYDGAVDDLATGDVRKVVDAAETAAGDGLEVAVGGPGAGLLQAPSVHYGEAVGVVVAAVVLFVAFGSLAAMALPIATALVGVGTAYWCVTLLGHAMAVADFAPMLGMLVGLGVGIDYALFIVTRHRRGLREGLPVGQAAQRAVATAGRAVVFAGVTVCIALLGMLVLRLNFLTGVAVAASLTVVLTVAASITLLPALLGVIGMKALSRRERRALVEHGPRPDVPRGLAARWAGLVQRRPRLLGALALVLMGVLALPVAALHLGSSDQGNHPASATTRQAYDMMAGGFGPGSNGPLTLVAHLDGAGDRVAFDSLPETLRGTPGVADATAAVHGKGGGTGLITVTPETAPQDEATSDLVDRLRSDVLPEAADGTSMQVHVGGITAGQDDFAEVIVDKLPLFGGVVIALGCLLLLVAFRSVGVPLKAALMNVLAVTASFGVVVAVFQWGWGAGLLGLGATGPIEPFLPVIMISVLFGLSMDYQVFLVSRMYEEWRATRDNRRAVRVGLAETGRVINCAALIMIAVFSAFALGGDRIIAMFGVALAAAVALDAFVLRTLLVPALMHLLGRANWWLPGWLEKRLPHIGVEGPGEPAAAEHIRLPEETAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N999</accession>
    <name>A0A0F7N999_9ACTN</name>
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        <submittedName>
            <fullName evidence="2">GlcNAc-PI de-N-acetylase</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="2 3">
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        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="LmbE-like_dom_sf"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF102588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="255" mass="27372" checksum="5367C4AD034A8C1E" modified="2015-07-22" version="1">MTDSAHASLAPLPDDWHRALAIVAHPDDLEYGTAAAVSKWTDAGKQVAYVLATRGEAGIDGMEPGECARVREEEQRASSAVVGVTALEFLDHRDGVIEEGLPLRRDLAAAIRRHRPELILTINHHDTWGAGPGAPRNTPDHRAVGRGVLDAVGDAGNRWIFPELLEQGLLPWGGVRWTAVAGSPYPTHAEEVTESARDRAVASLAEHHAYIVGLGEEDPHAYARTLIGEMLADTGRLCGTDLAVGFELVPHSFGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9A7</accession>
    <name>A0A0F7N9A7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fumarate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_23110</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017868.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_23110"/>
    <dbReference type="EnsemblBacteria" id="AKH84611">
        <property type="protein sequence ID" value="AKH84611"/>
        <property type="gene ID" value="AA958_23110"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_23110"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4872"/>
    <dbReference type="OrthoDB" id="1605514at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004489">
        <property type="entry name" value="Succ_DH/fum_Rdtase_Fe-S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025192">
        <property type="entry name" value="Succ_DH/fum_Rdtase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13085">
        <property type="entry name" value="Fer2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13183">
        <property type="entry name" value="Fer4_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00384">
        <property type="entry name" value="dhsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="3">
        <location>
            <begin position="11"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH84611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="261" mass="29639" checksum="6EE343B9393EEF53" modified="2015-07-22" version="1">MTTAPTTGYIARFKVWRGDTEGGGLEDFEVEVNEGEVVLDIIHRLQATQAPDLAVRWNCKAGKCGSCSAEINGRPRLLCMTRMSVFDREETITVTPLRAFPVVRDLVTDVGFNYEKAREIPAFIPPEKLAPGEYRMQQEDVDRSQEFRKCIECFLCQDTCHVVRDHEENKAAFAGPRFLMRVAELDMHPLDAAKDEGLDRRTTAQDEHGLGYCNITKCCSDVCPEHIKITDNALIPLKERAADRKYDPLVWLGSKIFRRKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9I2</accession>
    <name>A0A0F7N9I2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH-quinone oxidoreductase subunit D</fullName>
            <ecNumber evidence="5">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">NADH dehydrogenase I subunit D</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">NDH-1 subunit D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nuoD</name>
        <name evidence="8" type="ORF">AA958_20595</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the complex I 49 kDa subunit family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017474.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_20595"/>
    <dbReference type="EnsemblBacteria" id="AKH84188">
        <property type="protein sequence ID" value="AKH84188"/>
        <property type="gene ID" value="AA958_20595"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_20595"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4345"/>
    <dbReference type="OrthoDB" id="473681at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050136">
        <property type="term" value="F:NADH dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.645.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01358">
        <property type="entry name" value="NDH1_NuoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001135">
        <property type="entry name" value="NADH_Q_OxRdtase_suD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014029">
        <property type="entry name" value="NADH_UbQ_OxRdtase_49kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022885">
        <property type="entry name" value="NDH1_su_D/H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029014">
        <property type="entry name" value="NiFe-Hase_large"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11993">
        <property type="entry name" value="PTHR11993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00346">
        <property type="entry name" value="Complex1_49kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56762">
        <property type="entry name" value="SSF56762"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01962">
        <property type="entry name" value="NuoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00535">
        <property type="entry name" value="COMPLEX1_49K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 5 6" id="KW-0520">NAD</keyword>
    <keyword evidence="2 5" id="KW-0874">Quinone</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-1278">Translocase</keyword>
    <keyword evidence="1 5 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Complex1_49kDa" evidence="7">
        <location>
            <begin position="157"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH84188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="442" mass="48399" checksum="928331F7722576EC" modified="2015-07-22" version="1">MSTTHTTGAARETTEGTVYTVTGGDWDEVVESVHRADDERIVVNMGPQHPSTHGVLRLILEIDGETVTECRCGIGYLHTGIEKNLEYRTWTQGSTFVTRMDYLTSFFNEAGYCMAVEKLLGITDDVPDRATVIRVMLMELNRIASHLVAIATGGMELGATTVMIYGFRDRELVLDLFELITGLRMNHAFIRPGGLAQDLPPGAVDSIRETIKTLRKNFPEYDALATNNPAFKARMQDVAHLDLAGCMSLGVTGPVLRATGLPHDLRKTDPYCGYETYDFDVPTADTADAYGRFLIRLEEMRQSLRIVEQCVDRLEPGPVMVADKKIAWPAQLALGPDGLGNSLDHIKNIMGTSMEALIHHFKLVTEGFRVPPGQAYVALESPKGELGVHAVSDGATRPFRVHFREPSFVNLQAIAAMTEGGQVADVIVAIASIDPVLGGVDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9L7</accession>
    <name>A0A0F7N9L7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Protease HtpX homolog</fullName>
            <ecNumber evidence="12">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">htpX</name>
        <name evidence="14" type="ORF">AA958_20780</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CNQ-509</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cell membrane</location>
            <topology evidence="12">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the peptidase M48B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="12"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017509.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_20780"/>
    <dbReference type="EnsemblBacteria" id="AKH84223">
        <property type="protein sequence ID" value="AKH84223"/>
        <property type="gene ID" value="AA958_20780"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_20780"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4383"/>
    <dbReference type="OrthoDB" id="1918093at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00188">
        <property type="entry name" value="Pept_M48_protease_HtpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022919">
        <property type="entry name" value="Pept_M48_protease_HtpX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 12" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4 12 14" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8 12" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="33"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="143"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M48" evidence="13">
        <location>
            <begin position="68"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AKH84223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="289" mass="31319" checksum="1BF7ECA6721E65DB" modified="2015-07-22" version="1">MHRSNNGLKTAALLGGMSALILLIGSIFGRTGLVIALVVAIGTNAYAYWNSDKLALRAMRARPVSEIEAPNLYRIVRELSNEARQPMPRLYISPTPAPNAFATGRDPRNAAVCVTEGILQILDERELRGVLGHELMHVYNRDILISSIAGALASVVMFLVNFAWLIPSGDRNGNGPGPFGMLLVLFLGPVAASIIRLAVSRSREYEADQTGARLTGDPLALASALRKLEAGTKQLPLPPEPRIETASHMMIANPFRQGSGNMSRLFSTHPPMAERIARLERMAGRDLGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9M4</accession>
    <name>A0A0F7N9M4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_26805</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_26805"/>
    <dbReference type="EnsemblBacteria" id="AKH85245">
        <property type="protein sequence ID" value="AKH85245"/>
        <property type="gene ID" value="AA958_26805"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_26805"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5639"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH85245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="64" mass="6401" checksum="B76E3659926C3BCD" modified="2015-07-22" version="1">MAAAAVLVAVPGGAHGAPEAGADLPFVYNCPYPEGSGTFTLTDGGGNSGWDSTWEDCSAWPGQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9N6</accession>
    <name>A0A0F7N9N6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AA958_15710</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016724.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_15710"/>
    <dbReference type="EnsemblBacteria" id="AKH83412">
        <property type="protein sequence ID" value="AKH83412"/>
        <property type="gene ID" value="AA958_15710"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_15710"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3311"/>
    <dbReference type="OrthoDB" id="1753926at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006825">
        <property type="term" value="P:copper ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046688">
        <property type="term" value="P:response to copper ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032694">
        <property type="entry name" value="CopC/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007348">
        <property type="entry name" value="CopC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008457">
        <property type="entry name" value="Cu-R_CopD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014755">
        <property type="entry name" value="Cu-Rt/internalin_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34820">
        <property type="entry name" value="PTHR34820"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04234">
        <property type="entry name" value="CopC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05425">
        <property type="entry name" value="CopD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0186">Copper</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="336"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="375"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="409"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="441"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="602"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="domain" description="CopC" evidence="10">
        <location>
            <begin position="55"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="CopD" evidence="11">
        <location>
            <begin position="405"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="294"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="497"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="558"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="580"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AKH83412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="755" mass="76651" checksum="DB9716DF1389F884" modified="2015-07-22" version="1">MTPTGQLHRALRAPIRRRSMHRRGAHRRRALGALCAAVAAVLCVLVPGATPAAAHAALTGTDPAEGSVVQEAPQAVTLDFSEGVQLADDAIRVLDPDGNDVTKGGAAHADGNTKTATTALRPGLPDGTFTVVWKTVSADSHPISGAFTFSVGKPSKTTVTVSEAGEDNGSAKALYDTGRYMAYAGFVLLVGGAVFAGVCGGRNRVVRRVATGGWALLFAATVALLLLRGPYTGADFGLDSLRDVLETRPGTALLSRLLLLGAAAVVLAVLFGVYGRETAPGAKGARAEAKAGAGADADADAGEGSGTGTGPDAAEPATGQAEPAADGDDAARSRDLAIGLGLGGGVVAVGLAATWGMAEHASTGIQPWLAVPMTMLHLLAVAVWLGGLASLALSLRLGPRVPSYVIRRFSRLALTSVSLLAATGLYQAWRGLGSWGALTDTSYGQLLLVKLGLVAVLVTAGWTSRRWTHRLAGSGLTARAEGEGEPAEAHLVPAGATAEAGGTGSSGTAIAPGGASDGVSVPAQGSGAGSGSGSGSGCEPDDDASGDGPGADAGDGGDAGSRADDDPDRAAQLARQRAAVDATRARKERDSDPVRRGLRQSVFVETVLAVVLLSVVTLLTGTQPGRAETEQAAAESAQRQPVGPVKVKIPYDTGGQGGTGTAEITVDPGRTGDNQLHVYLTDANNQLLNVPEVRLSFTLEEKNVGPLDVTPTPVENGHWAATGVQLPMPGEWTLRITVRTSPIDQVTEEKKLTIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9X0</accession>
    <name>A0A0F7N9X0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">30S ribosomal protein S7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rpsG</name>
        <name evidence="10" type="ORF">AA958_21075</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the universal ribosomal protein uS7 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_027771073.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_21075"/>
    <dbReference type="EnsemblBacteria" id="AKH84269">
        <property type="protein sequence ID" value="AKH84269"/>
        <property type="gene ID" value="AA958_21075"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_21075"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4438"/>
    <dbReference type="OrthoDB" id="1540940at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="rpsG_bact"/>
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    </dbReference>
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        <property type="entry name" value="RIBOSOMAL_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <feature type="domain" description="Ribosomal_S7" evidence="9">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007151"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AKH84269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="156" mass="17468" checksum="7EE0F101099C4F63" modified="2015-07-22" version="1">MPRKGPAPKRPVHIDPVYNSPLVTSLINKVLLHGKRSTAERIVYGAMEGLRDKTGNDPVITLKRALENVKPAIEVKSRRVGGATYQVPVEVKPGRSATLALRWIVGYSRARREKTMTERLMNELLDASNGLGASVKRREDTHKMADANKAFAHYRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9X3</accession>
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        <name evidence="1" type="ORF">AA958_21100</name>
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    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
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        <lineage>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
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        <property type="gene ID" value="AA958_21100"/>
    </dbReference>
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    <dbReference type="PATRIC" id="fig|444103.5.peg.4443"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH84274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="104" mass="11784" checksum="29E1F5CDDE4EB072" modified="2015-07-22" version="1">MSDLYVDMETLDRVRHNIECISELMKRPGREMEDVDGWSMGVDALARRMDDFGNEWSYGIGQIEKFSDAASEALLKVKQEFQRVDGELADALPRTRSQAGGGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAG4</accession>
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        <name evidence="2" type="ORF">AA958_25695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
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        <lineage>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_25695"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5416"/>
    <dbReference type="Proteomes" id="UP000034283">
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Robl_LC7" evidence="1">
        <location>
            <begin position="12"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="140" mass="14697" checksum="14C930F28136FDC2" modified="2015-07-22" version="1">MSPMSQAAQNLNWLITNFVDNTPGVSHTVVVSADGLLLAMSDGFPRDRADQLAAVASGLTSLTAGASRIFEGGYVNQTVVEMERGFLFIMSISDGSALAVLAHPECDIGLVGYEMALLVDRAGAVLTPDLRAELQGSLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NB38</accession>
    <name>A0A0F7NB38_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AA958_23725</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017972.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_23725"/>
    <dbReference type="EnsemblBacteria" id="AKH84718">
        <property type="protein sequence ID" value="AKH84718"/>
        <property type="gene ID" value="AA958_23725"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_23725"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5000"/>
    <dbReference type="OrthoDB" id="1857862at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014322">
        <property type="entry name" value="RNA_pol_sigma-B/F/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02980">
        <property type="entry name" value="SigBFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="7">
        <location>
            <begin position="67"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r3" evidence="6">
        <location>
            <begin position="150"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4" evidence="8">
        <location>
            <begin position="232"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="12"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH84718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="287" mass="32544" checksum="806F6DB5D662D419" modified="2015-07-22" version="1">MTYVRGVPMRDEGRLAAAERERADHMDGLQQHDRREPQDRSGARAMFYELRKLPADSSEHAELRNALVQMHLPLVEHLARRFRNRGEPLDDLTQVATIGLIKSVDRFDPDRGVEFSTYATPTVVGEIKRHFRDKGWAVRVPRRLQELRLSLTSATAELSQLHGRAPTVHELAQKLNISEEEVLEGLESANAYSTLSLDVPDTDDESPAVADTLGAEDDALEGVEYRESLKPLLEELPPREKKILLLRFFGNMTQSQIAQEVGISQMHVSRLLARTLAQLRERLLVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NB59</accession>
    <name>A0A0F7NB59_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Alpha-galactosidase</fullName>
            <ecNumber evidence="5">3.2.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Melibiase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_29905</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
            <dbReference type="EC" id="3.2.1.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the glycosyl hydrolase 27 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.22" evidence="5"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018968.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_29905"/>
    <dbReference type="EnsemblBacteria" id="AKH85740">
        <property type="protein sequence ID" value="AKH85740"/>
        <property type="gene ID" value="AA958_29905"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_29905"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6315"/>
    <dbReference type="OrthoDB" id="469334at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052692">
        <property type="term" value="F:raffinose alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14792">
        <property type="entry name" value="GH27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002241">
        <property type="entry name" value="Glyco_hydro_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000111">
        <property type="entry name" value="Glyco_hydro_27/36_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041233">
        <property type="entry name" value="Melibiase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452">
        <property type="entry name" value="PTHR11452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16499">
        <property type="entry name" value="Melibiase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17801">
        <property type="entry name" value="Melibiase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00740">
        <property type="entry name" value="GLHYDRLASE27"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="SSF50370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00512">
        <property type="entry name" value="ALPHA_GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519333" description="Alpha-galactosidase" evidence="6">
        <location>
            <begin position="35"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B-type lectin" evidence="7">
        <location>
            <begin position="419"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH85740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="548" mass="57875" checksum="788C86CC6CA155E8" modified="2015-07-22" version="1">MLTRSRRRLARLLAAAAAVLALSGAAPHQPVAQAAPGSPAVTPPLGWNSWNSFGCGVTEDMVRQAADAMVSSGMRDAGYEYVVVDDCWFDPQRDAQGNLRAHPAKFPSGMKALGDYIHSRGLKFGLYQVPTERTCAQRVGTFPGSTGSMGHEVQDARTFASWGVDYLKYDWCSPAGTRDEQVARFSLMRDALRNTGRPIVYSINPNSFHAITGSTYNWGEVADLWRTTEDLLDIWQNGNVNSYPMGVGNVVDVNAPLAAQAGPGHWNDPDMLVVGRPGLSLTESRSHFTLWALMAAPLMAGNDIRTMSADVSAVLRNQRLLAVNQDPLGAGGRRVRDDGATEVFAKPLSDGSVAVGLFNRGSSTATVSASAAQIGLAGGAFTLTDLWTGATSSTSGQISASVPAHGVTAFRITGGTPLAAETSRIRGNGSGRCLDVENSSTAAGAAAVIWDCHTAANQLWTTWAGGEIRVFGDKCLDAENQGTANGTPVITWTCNGQDNQKWSFAADGSIRNVHAGLCLETSGAATANGSRLVLGACGGQTHQRWTRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NB81</accession>
    <name>A0A0F7NB81_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_23960</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018010.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH84758">
        <property type="protein sequence ID" value="AKH84758"/>
        <property type="gene ID" value="AA958_23960"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_23960"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5050"/>
    <dbReference type="OrthoDB" id="1677189at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519456" evidence="2">
        <location>
            <begin position="30"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH84758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="220" mass="23887" checksum="ECD46F279FD68023" modified="2015-07-22" version="1">MVRQFRSATLAAVAAAALLVSACGGDDSGSSDDKIEGAEKSSPAASPSAPGGDADAPEIKLPQSVELVFEDWESEDPEEQAVLDSGAQRQRATYEAITQDPPNPNSEYIPLYNMKGTGAWTSLQDWIGEFKDANATVEGTFRFFDPEVKVAGNGFTATLRFCSDERDVDQKNRETGKVLTQSDPYEYVEYRTTLQKNDEGAWQTADVTNHRDECNASGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBH8</accession>
    <name>A0A0F7NBH8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">LUD_dom domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_24360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018076.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_24360"/>
    <dbReference type="EnsemblBacteria" id="AKH84824">
        <property type="protein sequence ID" value="AKH84824"/>
        <property type="gene ID" value="AA958_24360"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_24360"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5133"/>
    <dbReference type="OrthoDB" id="1340948at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024185">
        <property type="entry name" value="FTHF_cligase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003741">
        <property type="entry name" value="LUD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02589">
        <property type="entry name" value="LUD_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LUD_dom" evidence="1">
        <location>
            <begin position="17"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="209" mass="22413" checksum="3978DD278D2001DE" modified="2015-07-22" version="1">MTTPAPSFTEPAPAERLEKVATALKGNGFEAEILDDAAAARARVKDLVPEGATVFTGASETLRLSGIDEDLNSERYDSVRTQSLAMDRTAQRKDIRRLLGHHDVIVGSVHAVTETGSLVIGSASGSQLTGYTGGSDHAIWVVGAQKVVPDVETGLRRLETHCTKLEDERAMKAYGVGSALNRVLILHAFNPNYYPGRGTVLLLREAIGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NC09</accession>
    <name>A0A0F7NC09_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_31575</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019233.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_31575"/>
    <dbReference type="EnsemblBacteria" id="AKH86005">
        <property type="protein sequence ID" value="AKH86005"/>
        <property type="gene ID" value="AA958_31575"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_31575"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6669"/>
    <dbReference type="OrthoDB" id="1542724at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="SSF51695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519351" evidence="1">
        <location>
            <begin position="32"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="GP-PDE" evidence="2">
        <location>
            <begin position="36"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH86005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="283" mass="30517" checksum="D4F9F41711BEC23B" modified="2015-07-22" version="1">MKLVRSLLRAAPVVAALTAAGILAGASAAQAAPAGPDVIAHRGSSGVAPENTAAATRLAVRQDADFVEIDVQRTRDGKLVNFHDCTMERTTDIEEVYPGRPSYRVSDFTWAELSRLDAGSWFSARYAGEPIITVDRVIDLIDRRSGLLAEISPCGHYDASLPADLAGLLQARPAYVERALANGRLAVQSFELDDAQGFKDLMPEVPIGFLDADRPTEAELAALSEWADQVNPQYTVTDQALVDRVHELGMDINVWTVDEPGAMRRMAGLGVDGIITDYPQSLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCE7</accession>
    <name>A0A0F7NCE7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GCN5 family acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_26260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018390.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_26260"/>
    <dbReference type="EnsemblBacteria" id="AKH85149">
        <property type="protein sequence ID" value="AKH85149"/>
        <property type="gene ID" value="AA958_26260"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_26260"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5528"/>
    <dbReference type="OrthoDB" id="1270792at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025289">
        <property type="entry name" value="DUF4081"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016794">
        <property type="entry name" value="UCP21603_acetyltransf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13312">
        <property type="entry name" value="DUF4081"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF021603">
        <property type="entry name" value="UCP21603_acetyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="140"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="281" mass="30335" checksum="2752FB773368909E" modified="2015-07-22" version="1">MLTTTTTRLLEPAELDAARAVLDREPVANAFVASRVAVAGLDPWRLGGELWGWYAGGRLESLCYAGANLVPVCATPEAVRGFAERARRAGRRCSSIVGLAEPTAELWSLLEPAWGPAREVRARQPLMVTTSMPAEVEPDPLVRRIRKDEMDLIMPACVAMFTEEVGISPLAGDGGLLYQARVAELVGGGRSFARVEDGEVVFKAEIGAATAHACQIQGVWVAPEHRGRGLSEIGLAAVLRYALREVAPVVSLYVNDFNTVARAAYRRVGFREVGAFMSVLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCL1</accession>
    <name>A0A0F7NCL1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_26095</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018359.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_26095"/>
    <dbReference type="EnsemblBacteria" id="AKH85118">
        <property type="protein sequence ID" value="AKH85118"/>
        <property type="gene ID" value="AA958_26095"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_26095"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5494"/>
    <dbReference type="OrthoDB" id="478143at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH85118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="470" mass="50685" checksum="A9F1CF511FA0BBEB" modified="2015-07-22" version="1">MTVSKDSSTAASGATPSATSKAAYDHLWMHFTRMSSYENAPVPTIVRGDGAYIYDETGKRYLDGLAGLFVVQAGHGRTELAEAAAKQAAELAYFPIWSYAHPKAVELAERLAAGAPGDLNKVFFSTGGGEAVETAWKLAKQYFKLTGRPGKYKVISRAVAYHGTPQGALSITGLPGLKAPFEPLVPGARKVANTNIYRAAGHGGAPEEPAAFGRWAADQIEQQILFEGPETVAAVFLEPVQNAGGCFPPPPGYFARVREICDTYDVLLVSDEVICAFGRLGHMFGCDRYGYVPDLITCAKGLTSGYSPLAACLVSDRVAEPFYAGGNTFPHGYTFGGHPVSCAVALANLDIFDREDLYGHVRANEEAFHATLRRLLDLPIVGDVRGSGYFYGIELVKDKATKETFTAEETERVLYGFLSRALFENGLYCRADDRGDPVVQLAPPLVADQAVFDEAEQILRGVLTDAWARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCZ8</accession>
    <name>A0A0F7NCZ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Acetate permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_26845</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018490.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_26845"/>
    <dbReference type="EnsemblBacteria" id="AKH85253">
        <property type="protein sequence ID" value="AKH85253"/>
        <property type="gene ID" value="AA958_26845"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_26845"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5647"/>
    <dbReference type="OrthoDB" id="278483at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="280"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="340"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="403"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="428"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="463"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="503"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH85253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="545" mass="55415" checksum="111BF264FC547E5D" modified="2015-07-22" version="1">MTGEHQKLALLLFCAFVALTLALALWAGRRHSSPEEFYAGGRLFTPMENGFAISGDYMSAASFLGISGLIALYGYDGVLYSVGFLVAWLVVLLLVAELVRNCGRFTLADVVASRLRRPRVRFAVGISSVTVSVLYLVAQMVGAGSLVALLAGDHTGAGARTAAVAGVGALMVTYVVLGGMRATTWIQIVKAVLLLAGALTLTVLVLLRFHGDPGALLEAAAGRSGHGSDFLAPGLAYGGGLADRLDFLSLGLALVLGTAGLPHILARFSTVPTATSARRSVVWSIGLIGGFYLMTIVLGFGAAALVGGDTVRADDPSGNTAVPLLALDLGGGAASTGGTVLFAVVAAVAFATILAVVAGITLASSASVAHDLYATVRRSRARRRAGRTPEGADGASAGAGEVAAARVAAAVVGALAIGLGLLARDLNVAFLVGLAFAVAASANLPVLLYALFWRRFTARGALWAVYGGLGPAVLLVVFSPVVSGSPDTLFPGVDFHVFPLQNPGLVSVPLGFFAGWLGTVTSAEPADPVRHAKTEVRALTGAGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7ND14</accession>
    <name>A0A0F7ND14_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_33615</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_33615"/>
    <dbReference type="EnsemblBacteria" id="AKH86350">
        <property type="protein sequence ID" value="AKH86350"/>
        <property type="gene ID" value="AA958_33615"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_33615"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.7098"/>
    <dbReference type="OrthoDB" id="1629121at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014036">
        <property type="entry name" value="DeoR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00455">
        <property type="entry name" value="DeoRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08220">
        <property type="entry name" value="HTH_DeoR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00037">
        <property type="entry name" value="HTHLACR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00420">
        <property type="entry name" value="HTH_DEOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="3">
        <location>
            <begin position="6"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH86350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="256" mass="27551" checksum="7ACB0C47D2AC85B3" modified="2015-07-22" version="1">MVVVDGEERRRVILETARRTGKVDVAKLAADLGVSRETVRRDLTLLEDHGLVRRTHGGAYPVESAGFETTLAYRTTMHVPEKSRIAAAAAELLGDAETVFIDEGFNPQLIAEALPRPRPLTIVTASLATASALAGDDRVTVLLLGGRVRGSTLATVDHWTTRMLAGFVIDLAYVGANGISRAYGLTTPDPAVSEVKAQAMRVARRKVFAGIHTKFGAVSFCRFAEVSEFDVIITDTGLPAAEAHRYSLLGPQVIRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7ND32</accession>
    <name>A0A0F7ND32_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_23335</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017908.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_23335"/>
    <dbReference type="EnsemblBacteria" id="AKH84652">
        <property type="protein sequence ID" value="AKH84652"/>
        <property type="gene ID" value="AA958_23335"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_23335"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4919"/>
    <dbReference type="OrthoDB" id="1107286at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH84652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="211" mass="21975" checksum="B29841B68397708E" modified="2015-07-22" version="1">MRGEPSCPKCGGRVRAPGLFTDSWQCERHGPVQPLQPVIPPSVEALGVVVHRAQVPVWMPWPLPLGWLFTGVANAGDDRSGGRATAVACSGPGPLGGPGELVLVAEELGVGLGARFAGVQGPDPGPGMCTDKPPDAKVIAAGRPTPLWHVGGVPADRAVFAGEARGLWLWAVVWPEQSGLLLYDELVLTDLRDAGAEIELLPCGALSPRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDC2</accession>
    <name>A0A0F7NDC2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_33045</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019473.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86246">
        <property type="protein sequence ID" value="AKH86246"/>
        <property type="gene ID" value="AA958_33045"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_33045"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6980"/>
    <dbReference type="OrthoDB" id="547386at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904380">
        <property type="term" value="P:endoplasmic reticulum mannose trimming"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904382">
        <property type="term" value="P:mannose trimming involved in glycoprotein ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044674">
        <property type="entry name" value="EDEM1/2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45679">
        <property type="entry name" value="PTHR45679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="SSF48225"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519422" evidence="4">
        <location>
            <begin position="35"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH86246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="487" mass="54603" checksum="1EECB3D4126AC896" modified="2015-07-22" version="1">MGTAAHHRTPLSRRRLLAAAAATSAAGAGALAQAAPARALPGPAAHPAAAVRVPAGPQAAREIRAEFLHAWNGYRAAAWGHDEVRPVSGTWNEFFAAGHPVGLSVIEALDTLYVMELDDDLTEAADWLEQNLDFDIDADFHVFEAIIRVVGGLLAGHLVTGRRSLLDLCVDFTDRLLPAFTKSPTGMPYTRANLRTGEVHGTTPPLAEIGTNILEFGMLSKLTGDGKYYEAAKRAYRAVLDRRSSLDLLGTRLDVETGRWTDPTDQGPNPPVDSFYEYLWGAWELFGDRDCLRWWRLLNGAMTEHLVEEWDGHVWYRQVDFATGETSGRRQSELASFWGGLVAKGGDRSLGERYHRSWESVLQRWPVLPEEIDYGTMTPTSRGNQFRPEYVNGAFDLYWLTKDDFYRRTAWQYFEGMKAHARVPGGYTILEDVTTSPMRQGDLFPAYAFAENFKYLYLMFARTRRFDGSDYVLSTEGKILRGLPRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDC9</accession>
    <name>A0A0F7NDC9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transcriptional regulatory protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_01910</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_01910"/>
    <dbReference type="EnsemblBacteria" id="AKH86495">
        <property type="protein sequence ID" value="AKH86495"/>
        <property type="gene ID" value="AA958_01910"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_01910"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.413"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024187">
        <property type="entry name" value="Sig_transdc_resp-reg_cit/mal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45526">
        <property type="entry name" value="PTHR45526"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006171">
        <property type="entry name" value="RR_citrat_malat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0010">Activator</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="2"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR006171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH86495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="225" mass="24439" checksum="9EC7FC27A2771E4E" modified="2015-07-22" version="1">MRVLVVDDDFMVAKLHSRYVAATEGFEVAGVAHSGAEALRAVARLRPDLVLLDVYLPDMDGIGVLRRLRAGEHADTDVLMITASRDAETIRGALHGGALHYVIKPFSQAALQEQLRHFAATRARLDALDDTGGVQQAHVDRLFSARPTVSGALPKGLNVRTAGLVERVLREHPDGLSASECAEAAAISRVAARRYLEHFADSGRAELTLKYGGTGRPEHRYRWAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDR0</accession>
    <name>A0A0F7NDR0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sulfatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_28765</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="PTM">
        <text evidence="3">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_28765"/>
    <dbReference type="EnsemblBacteria" id="AKH85574">
        <property type="protein sequence ID" value="AKH85574"/>
        <property type="gene ID" value="AA958_28765"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_28765"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6062"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00149">
        <property type="entry name" value="SULFATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase" evidence="4">
        <location>
            <begin position="44"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="3">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600917-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH85574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="703" mass="75326" checksum="AE40A694A9E96FF2" modified="2015-07-22" version="1">MASRRDVLAGSAAALGTSALSVSVGGPHLQTAAAQPARPAGGGPNVIMVLLDDLGYGDLGCYGHPLIRTPRLDRLARQGTRFTQGYCAAPVCSPSRAALLTGRVPPRTGIPDVLSRDDPHGLGTAERTLPEYLRTAGYVTAAIGKWHLGRLDAHHPARHGFDSFFGVDAMYTADTYPTEVWRDEQPVETLNSDADLATLTRRFTDEAIDVIDRAGDRPFFIYLAETMPHLPLAVEPEFDGISRGGLYGDAIESVDHHLGRLFDAIAERGLDRETLIIVAGDNGPWFEGSSGGLRSRKFEVFEGGVRVPFIARWTGTVPRGRESDDVVSFLDLLPTVCSLAGVEPEPGVPLDGTDLTATLRGARLRERAPVPFFLSARAAAVRDGRWKLHVRRRGSDQRYLPELYDLDADPRESVNLTARQPEVTARLQEFLTALEEDIAREQRPPVELTADLPLFAGRPHAVRVRLTRALRPGGDPVAEVTVSLAAPDGWATTAVREVVDLGTEPVIDVEVTPPAAVAAPAGRLATYALTPRVEIDGRTVTGEPVRGYAVPHGDDVALALDAGPAGSPVTPSYRALTPESSWTEEAGYGWTGGAPVPMSRDRGAPDVLRRDMVNNQPAALLRLRLPAGRSTVSVLRGDDDYATPGIVVAADGTEVLAPGPQVPAGAYQWEEFVLDGGASGRVTELRVGAPETANWKIVALLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDT1</accession>
    <name>A0A0F7NDT1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptide ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_28675</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018792.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_28675"/>
    <dbReference type="EnsemblBacteria" id="AKH85558">
        <property type="protein sequence ID" value="AKH85558"/>
        <property type="gene ID" value="AA958_28675"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_28675"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6043"/>
    <dbReference type="OrthoDB" id="1439650at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027476">
        <property type="entry name" value="DppA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007035">
        <property type="entry name" value="Peptidase_M55"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036177">
        <property type="entry name" value="Peptidase_M55_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04951">
        <property type="entry name" value="Peptidase_M55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015853">
        <property type="entry name" value="Pep_DppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63992">
        <property type="entry name" value="SSF63992"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="8"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR015853-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR015853-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH85558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="277" mass="29158" checksum="54C17CBF11ED9435" modified="2015-07-22" version="1">MKVLISADMEGATGVTWPADVLPGGPQWERCRPMFTSDVNAAIEGFFAGGADEVLVNEAHWTMRNLLLERIDDRAQMLTGRHKSLSMVEGVQHGDVDGIAFVGYHTGAGAEGVLAHTYLANSLTGVWLNGVRASEGLLNAHVVAEFGVPVVLVTGDDKTIEDAKGYAPAAPGVAVKDYVSRYAAVCRTPARTAADIRAAAAEGAALAVRAEPVRGGPFTVELEFDAEHLAGAATVVPGVAPTGERRVAYTTETMYEGIRCFKAVTTLVSAAVEEQYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDX8</accession>
    <name>A0A0F7NDX8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MFS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_24735</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018129.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH84877">
        <property type="protein sequence ID" value="AKH84877"/>
        <property type="gene ID" value="AA958_24735"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_24735"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5216"/>
    <dbReference type="OrthoDB" id="626204at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="136"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="204"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="261"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="289"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="323"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="349"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="9"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH84877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="384" mass="39032" checksum="F44F88B653DE06EC" modified="2015-07-22" version="1">MTEQRWPRRTFAGLIAALLCTFTAVGMVIPIIPKLVTAELDGSAFEVGVTFTVSGVVALLVRPYAGQLAQRTGCRRVMLCGAVLIVATAGLYALPFGLPGLYAARVLLGVGEAMLFMAGSLWTVSLAPQDRRAQIVGFYGLAMWSGFALGPVLGELVHRAGSFGAVWATAAALPAVAFCVIFALTDRVERGAAVSRKLLPRSAVLPGVSLACGSFGYAMVAGFAALAMTHRGVAHGSVVVSAFGVAYVTVRVVAGRIPDRVGALPVVVFSASVEALGMVLIAFASDLWLAALGALIAGGGFTLLYPALALITIDAAPESERGAALGAVTSFFDVAIGLSGLIGGVLAEVSYTLTFLIAAGAVLGSLYAGTAAARAAAARDPAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDY4</accession>
    <name>A0A0F7NDY4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Flavoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_29370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018898.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_29370"/>
    <dbReference type="EnsemblBacteria" id="AKH85669">
        <property type="protein sequence ID" value="AKH85669"/>
        <property type="gene ID" value="AA958_29370"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_29370"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6197"/>
    <dbReference type="OrthoDB" id="324612at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH85669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="465" mass="48017" checksum="EA4474977B96AF5D" modified="2015-07-22" version="1">MSAPLANAPATLPTVVIGAGPVGLAAAAHLTERGIEPLVLEAGPAAGSAVREWGHVRLFSTWSELVDPAAEKLLAPTGWTAPDGAAYPSGADWAERYLQPLADVLGDKVRYGATVTGVSRLGRDRLVDADRGQQPFTVRVTLADGSEQRILARAVIDASGTWSTPGPIGADGLPALGEHAASERVSYRIPDLKDPAVRARYAGRRTAVIGSGASAFTALAALADVATEEPGTHAAWILRRGISGATFGGGTADQLPARGALGLAAKAAVDQGHADAVTGFRTETIEPAEDGRLVLTGEDGRRLDPVDEVIVLTGLRPDLSFLSEMRLRLDERLQAPVELAPLIDPNQHSCGTVYPHGHRELSHPETGFYLVGMKSYGRAPTFLAMTGYEQVRSVAAAIAGDTESADRVELTLPETGVCGGAGLFDDPAGTKQSDGGGCCAPEPALVSIGVTTAAEGEQTSGGCCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NE81</accession>
    <name>A0A0F7NE81_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_29545</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018922.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH85693">
        <property type="protein sequence ID" value="AKH85693"/>
        <property type="gene ID" value="AA958_29545"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_29545"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6235"/>
    <dbReference type="OrthoDB" id="1582456at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="276"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH85693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="298" mass="31003" checksum="A4C2BE3485655954" modified="2015-07-22" version="1">MRPTAAGRPRGRSPLAGRTAVITGAARGVGAALARELAGRGARIALLGHEGTALDAVASTLPTPSLTLDVDVTDADALRDAARAVRDRLGRPSVVVANAGIAQAGPFETADLRSWRRVIDVNLTGSAYTAAAFQPDLLLTRGYYLQIASTAALTGMPLMSAYSAAKAGVETFAHALRAETAHRGMAVGIAYLHWIGTDMIDEPDQVPALREVRTLLPPGARHVSSAHPAAARLAQAVEDRSTALYVPSWTRVVQIGRIAWPGVVALRARLRFSGPGDRPIEQTGPLGPGGAADLAAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NED7</accession>
    <name>A0A0F7NED7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_25745</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the bacterial histone-like protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018303.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_25745"/>
    <dbReference type="EnsemblBacteria" id="AKH85057">
        <property type="protein sequence ID" value="AKH85057"/>
        <property type="gene ID" value="AA958_25745"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_25745"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5423"/>
    <dbReference type="OrthoDB" id="1847472at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000119">
        <property type="entry name" value="Hist_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020816">
        <property type="entry name" value="Histone-like_DNA-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010992">
        <property type="entry name" value="IHF-like_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33175">
        <property type="entry name" value="PTHR33175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00216">
        <property type="entry name" value="Bac_DNA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01727">
        <property type="entry name" value="DNABINDINGHU"/>
    </dbReference>
    <dbReference type="SMART" id="SM00411">
        <property type="entry name" value="BHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47729">
        <property type="entry name" value="SSF47729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00045">
        <property type="entry name" value="HISTONE_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="130"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH85057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="220" mass="23021" checksum="CF2785D832CC3FEA" modified="2015-07-22" version="1">MNKAQLVEAITDKMGGRQQAADAVDAVLDAIIRAVVSGERVSVTGFGSFEKVERPARYARNPQTGERVRVKKTSVPRFRAGQGFKDLVSGTKRLPKHDTAVKKAPKGSLSGGTKTTAKAAAKKATKKATAAAKKATAKKTTAKKTAAKKAPAKRTATAKKSSAKKTTAKKSSAKKAAAKKTAAKKSAKKAPAKKATAKKAPARKAAGRRTTAKKTTARKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NEI5</accession>
    <name>A0A0F7NEI5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Gamma-aminobutyraldehyde dehydrogenase</fullName>
            <ecNumber evidence="6">1.2.1.19</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_26115</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.19" evidence="6"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018363.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_26115"/>
    <dbReference type="EnsemblBacteria" id="AKH85122">
        <property type="protein sequence ID" value="AKH85122"/>
        <property type="gene ID" value="AA958_26115"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_26115"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5498"/>
    <dbReference type="OrthoDB" id="744602at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033737">
        <property type="term" value="F:1-pyrroline dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019145">
        <property type="term" value="F:aminobutyraldehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="5">
        <location>
            <begin position="27"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="262"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH85122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="504" mass="52477" checksum="A01BA203CDFC23CF" modified="2015-07-22" version="1">MAPRLEAAARFAPGAQFVAGRLVPGTSGRVQTVTDPATGAEVLRYELAGPADVDAAVAAAAAAQPGWGASTPAERSDALHRLAGLLAERAEEFAYAESLQCGKPIRLSTEFDVPGTVDNAAFFAGAARLPEGRAAGEYSADHTSAVRREPVGVVGSIAPWNYPLQMAAWKVLPAVAAGNAIVLKPSELTPLTSLMFAEAAADAGIPAGVVNVVCGAGPDAGEHLVGHPDVAMTSFTGSTAVGRRVAALATAAGAGVKRLHLELGGKAPFVVFDDADLEAAVHGAVAGALINTGQDCTAATRAYVQRPLYDAFVDGVAALMARVRLGDPFDPATDLGPLVSYAQRDRVAAFVDRARAAGARVVTGGRAPDRTGAYYEPTLVTGAAQDSEIVQSEVFGPVLAVLPFDGDDEGIALANDTPYGLAASAWSRDVYRTARAAREIRAGCVWLNDHIPIISEMPHGGYRASGYGKDMSVYSFEEYTQIKHVMQDITGTARKEWHRTVFTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NEN7</accession>
    <name>A0A0F7NEN7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_13835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_027753143.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_13835"/>
    <dbReference type="EnsemblBacteria" id="AKH86746">
        <property type="protein sequence ID" value="AKH86746"/>
        <property type="gene ID" value="AA958_13835"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_13835"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2913"/>
    <dbReference type="OrthoDB" id="2064544at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519564" evidence="1">
        <location>
            <begin position="30"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="64" mass="6557" checksum="E5F691672762D93D" modified="2015-07-22" version="1">MAVSVSVVLLLLVLAVVFLRSGSLKTSHAVVCVLLGFYLSGTTVAPTIQSGLEATANVVSSIRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NEV0</accession>
    <name>A0A0F7NEV0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">AA958_26840</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018489.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_26840"/>
    <dbReference type="EnsemblBacteria" id="AKH85252">
        <property type="protein sequence ID" value="AKH85252"/>
        <property type="gene ID" value="AA958_26840"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_26840"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5646"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033463">
        <property type="entry name" value="sCache_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029151">
        <property type="entry name" value="Sensor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016120">
        <property type="entry name" value="Sig_transdc_His_kin_SpoOB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039506">
        <property type="entry name" value="SPOB_a"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17203">
        <property type="entry name" value="sCache_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14689">
        <property type="entry name" value="SPOB_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103190">
        <property type="entry name" value="SSF103190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55890">
        <property type="entry name" value="SSF55890"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="185"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="14">
        <location>
            <begin position="428"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AKH85252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="554" mass="58588" checksum="4087C69192858C67" modified="2015-07-22" version="1">MGAPSTARRGEPRGSGRRLGWPRRVSSQILLMQLALATGVTILAAALFLAPYSDELDRQVMRRAMAIAQSTAVDPGLAEALLTTPADPDGPVQRRAERIRRATGAEYVVVLDTRGVRWSHTLPERVGHRVSTDPSAALAGEEWMGIDTGTMGRTARGKVPLYDREGRIVGAVSVGIPYEGVRDRVIAAVPGVLAYAGGALAVGALVAFAHSRRLQRRTRDLAFSDIAALLDEREAMLHGIREGVVALDGAGRLRLVNDEAARLLGIDPEHTGRPLDDVLRPGRTADVLAGRVAGSDLLTVSDGRVLVANRMPTADGGAVATLRDRTELEQLGRELDSTRGLIDALRAQDHEHANHLHTLLGLLELGMTEEATEYIAEAAGGRRATAEQVTGRIRDPLLAALLVGKATVAAERGVPLVLTGELPDRAVDPRGLVTIVGNLVDNALDAAVGSPVPLVEVDLRADGETVRLRVADSGPGIPAERRELVFADGWTTKEPPAHGKRGLGLALVRRLAERHGGHAEVGERPGGGAEFTVVLPEALAPAPGRVPGSRLPVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NEV2</accession>
    <name>A0A0F7NEV2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ROK family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_31420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ROK (NagC/XylR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019207.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_31420"/>
    <dbReference type="EnsemblBacteria" id="AKH85979">
        <property type="protein sequence ID" value="AKH85979"/>
        <property type="gene ID" value="AA958_31420"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_31420"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6639"/>
    <dbReference type="OrthoDB" id="1130699at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01125">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="399" mass="40884" checksum="F13F06FF52C3C615" modified="2015-07-22" version="1">MRNQASAGQLLQLIRTGEATTRAALQEATGLSRSTVAGRLDALQAAGWLRGAAGVSTGGRPSVQLEFDTGHAVVLAADLQTRHGRAAVLDLAGRPLAERTGELRVGDGPEPVLDELGRWFGPLLAEAGRGADEVCGIGISVPGPVDFDTGVVVQPPIMPGWDGYPIQDHMRRSFAKHAEGPEDVPVLVDNDANLLAYAEQRAGYADCAAFVLVKVSTGIGAGVVVDGRIYRGIDGGAGDIGHVRLHDGMDALCACGSYGCLAAVASGRALAGRLTELGVPATSGSDVRDLLAAGQPDAVRLAREAGMRAGEVLATVVTLLNPGVLMIVGDLAGTPFLTGVRELLYQRAMPRTTAHLQVVTPGLGDAAGLAGAGALVVEHLYAPGRADERLAARGGSGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFV4</accession>
    <name>A0A0F7NFV4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AA958_32745</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNQ-509</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Antibiotic biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019425.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_32745"/>
    <dbReference type="EnsemblBacteria" id="AKH86198">
        <property type="protein sequence ID" value="AKH86198"/>
        <property type="gene ID" value="AA958_32745"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_32745"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6918"/>
    <dbReference type="OrthoDB" id="572620at2"/>
    <dbReference type="UniPathway" id="UPA00920">
        <property type="reaction ID" value="UER00891"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901362">
        <property type="term" value="P:organic cyclic compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd05235">
        <property type="entry name" value="SDR_e1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="Far_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010080">
        <property type="entry name" value="Thioester_reductase-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01746">
        <property type="entry name" value="Thioester-redct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 7" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="983"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="2080"/>
            <end position="2155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="246"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="964"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1537"/>
            <end position="1563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1543"/>
            <end position="1563"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="7">
        <location>
            <position position="1018"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="7">
        <location>
            <position position="2115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AKH86198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="2548" mass="268303" checksum="D9BDBAACA1063D78" modified="2015-07-22" version="1">MSRSQVFAAHGGAGAPVRDRPADVPDTLPVTAGQREVWLAEQYSPHHRSALRLGEYLAIDGPVERDLFEAALRHVVGEADALRVRLVPGADGPVQVLEREPPWQLAFVDLSGATDPEAAGRAWADADVARPMDLARGPLFSFALLKLGPDRFWWYHTYHHAAVDAFGYALVARRVAEVYTALVRGREAGPSPFGPLAALVQADRKYQDSAERTADRAYWKRQLAGWTRAATADAGAVHDAAARLPQQRPASGGPGAEGPVASDPAQPAVPRTPLLPLLRPEALRAAARRAGVSRFRLVFAAVALYEHRRTGARDVVVGLTVAGRTGPASRTTPGMLANSVPVRLTVRPGMPLRDLLAQVDDRMREAVEHQRYRAEDLHRDLGLSRGPGTAYTPMVNLIGFDYDISFAGHRCTAHNLSFPLAADLMIMVWDRRDGTGPHMRLHAPPGEYGTAELADTQRRLLDAVAHLADADPDLPVGRLEALPAAERRQLLALGDATAAAAPPAPVAALFEAQVRRTPGAPALESAGTAVSYAELNARANRLAHAMAARGIGAEDVVALVLPRSVDLVVAELAVLKAGAAYLPVDPGYPPARRKFMLTDARPALVLDDPRTLAELAAGQPATDPGIVVDPRRPAYVIYTSGSTGRPKGVMVPHTGVASLVAFHTERLRITPGSRIPQLASPGFDACAWEMCVALLTGATLVLAPGGDPLAVLTEPGFGITHAFVPPSALTAVAEQDSPVTTLAVGGEPVPPGLVARWAPGRRLMNVYGPTETTAMVTTSLPLTPDGTAPPIGRPHSGTRLYVLDGALRPVPVGASGELYIAGVSLARGYLRRPGLTALRFVADPYGPPGTRMYRTGDVVRWRADGQVDFVGRADRQVKIRGFRIEQEEVEAALLACPGVARAAVLARRDPPGGDLRLVAYVVAAEDGLSGPLLRARLCARLPGFMVPAAFVMLGDLPLNANGKVDRDALPAPEPDPEEAAGAPPRTPRERLLCELFADVLGVPRVGADTDFFALGGHSLQAIRLVARIRTALGADLALSALFEAPTPARLAARFGAGPARPALTAATGPAAEAAPLSYAQQRLWFLHRAEGPAATYNIPLAQRFTGELDRDALERALGDVVARHESLRTVFPDTGGDGTGPRQRILGAAAARPALPVTEVAGAGELRRKLAEAVRYTFDLAVEPPLRAELFVLGPAHAVLCLVIHHIAADGWSMAPLTRDLATAYAARLRGEEPDWAPLPVRYTDYTLWQCRLLGAPEDPDGLLHRQLAHWTAALAGLPDEIALPRDRPRPAVASYAGGRVLLHIDAELHAALAEVGSRSGATLFMVLHASLAALLTRLGAGTDLPVGSVIAGRTDEALDELVGFFVNTLVLRTDTSGDPAFAELVERVRDTALAAYAHQDVPFERLVEALNPPRAPGRHPLFQIALSVDADETAEFTLPGLRTSRIRVPTRTAKFDLDIGIGERRSAAGERLGLTGTLDYATDLFDHTTVQDFADRWVRLLRAAVAEPGLPISRIDVLSGAERRLLVGSAAAGAGTGADADADGDAHADADAGTDVDGDREAAPARTLTELFAVRVRTTPGAVAVAAAGTELTYAGLDARANRLAHALAARGAGPEDIVAVALPRSADLVVALLAVLKAGAAYLPLDPGYPAPRLAAMVADARPVLLLTDTATASAGTLGAGVPRLLLDDPAQAAEPAELPGTAPAPGPRPGHPAYVIYTSGSTGAPKGVVARHASVAAVAERYGKQVFGPVARRAGGRPLRIALTASVSFDASWGQLAALTAGHELHLPDDRTWTDADRFVAWLAERRIDSVDVTPSHMQVLCARGLFADGRPRPALAVLGGEALPEGLWRELRAVPGLTAHNMYGPTECTVDCVQARLDATRTPVLGRPVPGARAYVLDAALRPVPPGVTGELYVAGTGLARGYLRRPGETALRFVADPYGPPGARMYRTGDLARPRRDGRLDFAGRADDQVKIRGHRVEPGEVEAALAAHPAVARAAVVARADQRGDTRLVGYAVPAAGEPETAALRAFLRTRLPAHAVPAAIVALPALPLTPSGKLDRRALPAPAPAASPGAGRAPRTPYEKALCELFAEALDLPAVGVDDDFFALGGHSLLATRLAGRIGERLAVPFGLSALLEAPTPAGLARQLGAEGPRAAPSWVPDSEAKLSPALRFTGAPPPAGGPREVLLTGATGFVGAFLLAELLGATTARVHCLVRAGTADEAHERLAAALRGYGLGAAAGDPRTVAVPGDLGAVDLGAGPEHWARLRDGVDTIVHAGARVHHVSPYALLKPANVEGTRTLLGLAAEGRPKAFHHLSTLGVFRAYGAGAPPVTEESPTGGEQHPYGKGYSASKWVADRLVERAFARGASGGIHRLGRIWAHSATGAVNRDDMYSRLLVSCAELGCHPVDPALDEALLPVDVLARAVVTLVLRDDGGPGSVHHLHHPRRTGPGAFMAGHGRLHGTRSAAVPLASWLGRLRAAGARGRELPIAPYREYLEDLAGTAGTRAQQVFDNGRTVGLLRRYGVGIPDVDEAAVDAYWTFMKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NG15</accession>
    <name>A0A0F7NG15_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phosphonopyruvate decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_29495</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018916.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_29495"/>
    <dbReference type="EnsemblBacteria" id="AKH85687">
        <property type="protein sequence ID" value="AKH85687"/>
        <property type="gene ID" value="AA958_29495"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_29495"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6224"/>
    <dbReference type="OrthoDB" id="1219810at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033980">
        <property type="term" value="F:phosphonopyruvate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032923">
        <property type="term" value="P:organic phosphonate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017684">
        <property type="entry name" value="Phosphono-pyrv_decarboxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03297">
        <property type="entry name" value="Ppyr-DeCO2ase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="4">
        <location>
            <begin position="5"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="3">
        <location>
            <begin position="216"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="334"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH85687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="373" mass="39170" checksum="107724ECFFCC428B" modified="2015-07-22" version="1">MIEADIFCGELEQRGFARASGVPCSFFGGPIAHLSRTPGRYTPAANEGNAVAVAVGAALAGERCYVMLQNSGLGNLVNPLTSLVMTYRIPVLTFVSLRGWPDPAQDEPQHEVMGGITQPFLEMLGLPRWILRADVSHEEFSGILDEAEAAVSKGQAPFVLVEKGAVGKCPPGEDSAAEARQHSGEVVSLVSELAGEAPVIATTGFTGRELFGLDDRPRNFYMQGSMGHASSIALGVALAQPRTPVFVLDGDGAALMHLGALSAIGDQAPGNLVHVVLDNGIHESTGGQSTTSAGTSIEEVARAAGYATAERCRSLEQVREQVTRALHSPGPHLILVPTRARTGPMPPRATATHSPENMRDRFARAVQAASGLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NG32</accession>
    <name>A0A0F7NG32_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Crystallin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_33265</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019513.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_33265"/>
    <dbReference type="EnsemblBacteria" id="AKH86288">
        <property type="protein sequence ID" value="AKH86288"/>
        <property type="gene ID" value="AA958_33265"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_33265"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.7026"/>
    <dbReference type="OrthoDB" id="1661477at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4080.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005502">
        <property type="entry name" value="Ribosyl_crysJ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036705">
        <property type="entry name" value="Ribosyl_crysJ1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03747">
        <property type="entry name" value="ADP_ribosyl_GH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101478">
        <property type="entry name" value="SSF101478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH86288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="407" mass="42077" checksum="A6E58586FF4F6C00" modified="2015-07-22" version="1">MTPTTASATPGDPAATAATASTAATAAPGLADRTAGCLVGAAVGDALGGPVEGWTPEAIAERYGGRVRGIVEPFHRDAWRTARPIAPYHKGDGHVTDDTLMTHALIRVYDKVRDHLDAYAVADHLVPDLMGTPRWIPELEAEALPLQRIFLAEKWIVARLHYGHVDPREAGVGNIVNCGAAMYMAPVGAVNAGNPAAAYAEALDVAGAHQSSYGREAAGVFAACVAAAFAPGATPESVVEAALALAKDGTRAAIEAVCEAAAGRTDVEEALAPLRAAVEPYDTVGPEYRNPSLGARRPSRLHAIEELPVALGMLLVGRGDYRHTVLGAVNYGRDCDSIATMGGAIAGALGGAAAVPGEWAEEVARASRLDLLAPAATLTEVAREVFVRDVARRRAHEAVFGALAEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NGA2</accession>
    <name>A0A0F7NGA2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">LuxR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_30165</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019005.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_30165"/>
    <dbReference type="EnsemblBacteria" id="AKH85777">
        <property type="protein sequence ID" value="AKH85777"/>
        <property type="gene ID" value="AA958_30165"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_30165"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6370"/>
    <dbReference type="OrthoDB" id="1687028at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="5">
        <location>
            <begin position="16"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="4">
        <location>
            <begin position="159"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH85777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="235" mass="24991" checksum="2ABA1F2CD7A7D650" modified="2015-07-22" version="1">MTGSDGFAASAAAPIRVFLLDDHDVVRRGLRDLLEDEPDIRVAGEASTAEEAVARGPALRPDVAVLDVRLPDGDGIAVCRELRSRMPDLPCLMLTSFDDDEALLDAILAGAAGYVLKQIKDSDLVAAVRTVASGQSMLDPATTSRLLDNLRGGPEESGEEGPLSGLSPREREILGLIGEGLTNREIGERLYLSEKTVKNNISRLLGKLGVERRIQAAVIASEEGVRPGGDGARDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NGC5</accession>
    <name>A0A0F7NGC5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">(4Fe-4S) protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AA958_02240</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019727.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_02240"/>
    <dbReference type="EnsemblBacteria" id="AKH86504">
        <property type="protein sequence ID" value="AKH86504"/>
        <property type="gene ID" value="AA958_02240"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_02240"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.481"/>
    <dbReference type="OrthoDB" id="688908at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019516">
        <property type="term" value="P:lactate oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004452">
        <property type="entry name" value="4Fe-4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024569">
        <property type="entry name" value="4Fe-4S-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024185">
        <property type="entry name" value="FTHF_cligase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003741">
        <property type="entry name" value="LUD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47153">
        <property type="entry name" value="PTHR47153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11870">
        <property type="entry name" value="DUF3390"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13183">
        <property type="entry name" value="Fer4_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02589">
        <property type="entry name" value="LUD_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="LUD_dom" evidence="8">
        <location>
            <begin position="69"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="10">
        <location>
            <begin position="313"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3390" evidence="9">
        <location>
            <begin position="407"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="446"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF11870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AKH86504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="487" mass="52569" checksum="329622F2DE827FE5" modified="2015-07-22" version="1">MPRTRPAAFPQSAAAATADATLRANLTHATRTIRGKRAAAVAELADWDRLRAAGAAIKDDTLRHLDHYLEQLEAAVTAAGGHVHWAVDAAEANAIVTRLVRETGADEVVKVKSMATQEIGLTEALAEAGIRAYETDLAELIVQLGEDLPSHILVPAIHKNRGEIRDIFRDRMADWGRPAPAGLGDRPAELAEAARLHLREKFLDARVAVSGANFMVAETGTMVVLESEGNGRMCLTLPETLISVVGIEKLVPSWRDLEVFLQLLPRSSTAERMNPYTSTWTGPAEGDGPRDFHLVLLDNGRTDTLSDQVGRQALRCIRCSACLNVCPVYERAGGHAYGSAYPGPIGAILTPQLRGTASALDASLPYASTLCGACYEVCPVAIDIPEVLVHLRTRVAEGGTYTVRGTKAVIKPAKGHAAERAAMRAARWTMDHPRVYGAALRATTGTRRLHPRRLPGPGKAWSATRDLPPVPKESFRAWWQRTRGAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NH65</accession>
    <name>A0A0F7NH65_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_15405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86794">
        <property type="protein sequence ID" value="AKH86794"/>
        <property type="gene ID" value="AA958_15405"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_15405"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3242"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="SSF50969"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519457" evidence="1">
        <location>
            <begin position="22"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="448" mass="46046" checksum="1E36155A677656A8" modified="2015-07-22" version="1">MGFAALASSFALSLPSTPATATPATARATAVGLPLSSYWEMVVESSRQRVFLSDPTGDSVLVTDYEGQPVAHLTGMPGASGLALSPDSRTVYVALRDADAIAAIDTGTLVEAARYATEGSTPVSLAPAGGKIWFGYNGDDPLAPGDIGSLDLSGAQPVLQTGQGGNWHSAPLLASAPAAPDRLVAGEKNLAPASIGSYDVSTGTAQLLGKQRDFGPDGSDYLTDLAVSADGESFVPATDVFPETQVQVFDIDDLSFRGAYPTPARANSVDIAPDGTVAAGTYLSDGDDLHVFKPGAYAPLQSVDLDLDPSSYLPPRGVAWVPDRSRIFVVSRGADNFSLHALDGGFGTAQTALTLDAPDTSKKNRELTVTGALAPAGTFGPGTAVTVTRYDNGHPEGFPGGSVTVDDNGTFSFTDRPGEPGPVTYEVSYAGDDWHTPISGDATVEITG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NHA0</accession>
    <name>A0A0F7NHA0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AA958_10320</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019931.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_10320"/>
    <dbReference type="EnsemblBacteria" id="AKH86663">
        <property type="protein sequence ID" value="AKH86663"/>
        <property type="gene ID" value="AA958_10320"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_10320"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2175"/>
    <dbReference type="OrthoDB" id="760677at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="7"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="123"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="238"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH86663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="385" mass="41660" checksum="89A87953256B2D09" modified="2015-07-22" version="1">MRRTVFNEDHEAFRETIRDFIAAEVVPYYHDWMEAGAVPRELYKKLGELGVFGIEVPEEYGGAGEHSFKFNAVISEECARAGVSFGGSSVHTALCLPYLLKYGSEEQKRRWLPPFVSGDMMTAIAMTEPGTGSDLAGMKTTAKLSDDGTHYVLNGAKTFITGGVQADRVLVCARTAPPTPEDRRGGISILVVDASSAGYAVGRKLDKLGLKSSDTAELSFTDVKVPVGDLLGEEGKAFTYLTHNLPQERLGIAVGAYAQAAAAVRFAVAYVKERTVFGRAVAEFQNTKFVLADCKAEVDAMEAYVDRALEVHDAGDLGVADAAAVKLFCTERAAVVIDKCLQLHGGYGYMNEYPISRLYADTRVTRIYGGTSEVMRSIVAKSMGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NHH3</accession>
    <name>A0A0F7NHH3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Replicative DNA helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_18790</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_18790"/>
    <dbReference type="EnsemblBacteria" id="AKH86879">
        <property type="protein sequence ID" value="AKH86879"/>
        <property type="gene ID" value="AA958_18790"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_18790"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3945"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.860.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036185">
        <property type="entry name" value="DNA_heli_DnaB-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007693">
        <property type="entry name" value="DNA_helicase_DnaB-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016136">
        <property type="entry name" value="DNA_helicase_N/primase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00772">
        <property type="entry name" value="DnaB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48024">
        <property type="entry name" value="SSF48024"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DnaB" evidence="4">
        <location>
            <begin position="3"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="DnaB" evidence="4">
        <location>
            <begin position="175"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="313"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="337"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH86879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="352" mass="38274" checksum="71774A3169041DD5" modified="2015-07-22" version="1">MFHTEQALLGALLFDPRRLDDVSGIAADSFATAAHAALYTAITTLPRPDPAEHAKNTKWLDRVLATSREQARGLTASYLHTLIHLCPRPSHAAAYARIVEAEHARRRLHTAAERLVHTIHDTSLPHPVETVLAEADALAAVVDDIANRFPTRAGVLPRTTPPPPGAAPGHTEAVGEEQILLATATARPSGIEAVRWLLPDDFTLPLHAGLWQCITTLARRHEPVDPVTVLWGAHQRGLLNDGAEPDEVLRLLAEPAGSVEHWAERVLQRSLLATAEDTGRRIKVFADDAANTPYQLIVGTRRALADLAAARTRWQHATAPTPPQKRRRPPTTRAGPPTTTPAHATRGTRATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NHN6</accession>
    <name>A0A0F7NHN6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_21530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020295.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86944">
        <property type="protein sequence ID" value="AKH86944"/>
        <property type="gene ID" value="AA958_21530"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_21530"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4533"/>
    <dbReference type="OrthoDB" id="2216405at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="145" mass="14685" checksum="AD3C4F002640145F" modified="2015-07-22" version="1">MTTADSRGRLLQALAVGAAATVAGALVLGGTQGLVGERGLELGYWALALGLLVGAAVGRAGAESRGSAFLAIPVALAGVLLTQLAATAVHLGTADVGAAYDFWRSGVLGKNDMTFYLVAAAEAFLVSQRVSEVRNSMSQSRHDSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NHV3</accession>
    <name>A0A0F7NHV3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_25690</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020410.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_25690"/>
    <dbReference type="EnsemblBacteria" id="AKH87034">
        <property type="protein sequence ID" value="AKH87034"/>
        <property type="gene ID" value="AA958_25690"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_25690"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5415"/>
    <dbReference type="OrthoDB" id="811938at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013587">
        <property type="entry name" value="Nitrate/nitrite_sensing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010910">
        <property type="entry name" value="Nitrate/nitrite_sensing_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08376">
        <property type="entry name" value="NIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50906">
        <property type="entry name" value="NIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="331"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="NIT" evidence="6">
        <location>
            <begin position="45"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="235"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="735"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="235"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="820"/>
            <end position="840"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH87034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="920" mass="99329" checksum="31844103B5D542D1" modified="2015-07-22" version="1">MATRLNAILLIPVLVAIVFAGFQVNSSVDTWQEAQDAENTAKVAKAAGDYAERLMAERDVSVQPLLHGDREASRVTEARKATDAAAAEFDRQVEDMPDKPGLQRRLDAFRDQEKNLEKMRQAAFTPQAAGTDTHLGYAQMYRPLMTFANEVGLGTSNITTYGRAMYAISLAKSSASLVRSIGTELLVSPPEKAGVLAEEKTALASFAYLEPIALDEFRTGSTAADNRMLKDALADQEEEAKQRLAEAQREAEGGGGEFTAPPEPAAMLAGVASIGEDVTPADLAEQGITPQTWYAATSVPIAAYRTVEIEFADRAVADAHEIVESAKRDTVVGAAIAVGALLIGFVIAAMMARSMGRSMRLLRNSAFGIAEQRLPMLVDQLSRTDPGRVDTRVQPIPLHSRDEIGEVARAFDQVHREAVRLAAEQALLRGNLNAIFTNLSRRNQGLIERQLELISGLEDHEADPEQLENLFHMDHLATRMRRNGENLLVLAGEDTGRHMDEAVPLVDVLRAATSEVESYERIELEGVPDSEIHGSAVTDLVHLLAELLENATTFSSPHTKVRVTATRLPDRRVMVEIHDKGIGLTAEDFADINHRLANPPTVDVAISQRMGLFVVGRLADRHGIRVQLRPSGEQSGTTSLVMLPEAIAFGGATEAPEQHDEFTVSRIVADRPSFQPAGNGFAGGRPRSAAELGFDDSPYPQVEPERPAMPALGGQEGVFDPIQRSLLREERRAALEAAAQDRTPGFRDPEAEAAGTDAFTPGGISPEPAYDTYGQAEPGPASNHWTGQGAYDSPAVPEAESTAQLGTGRGGFGFGEPEPAPADDEWRSANDERWERAGQVREPKAGGITPAGLPRRVPRQNLVEGTAEQAPLGGPQVSRAPEDVRGRLSNLRRGVQQGRERGPQRNDGPGVGPGTYDQER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NHW4</accession>
    <name>A0A0F7NHW4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Crystallin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_26700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_26700"/>
    <dbReference type="EnsemblBacteria" id="AKH87049">
        <property type="protein sequence ID" value="AKH87049"/>
        <property type="gene ID" value="AA958_26700"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_26700"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5618"/>
    <dbReference type="OrthoDB" id="1661477at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4080.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005502">
        <property type="entry name" value="Ribosyl_crysJ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036705">
        <property type="entry name" value="Ribosyl_crysJ1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03747">
        <property type="entry name" value="ADP_ribosyl_GH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101478">
        <property type="entry name" value="SSF101478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH87049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="310" mass="32048" checksum="0626593ECB21596A" modified="2015-07-22" version="1">MPDAPLVRALASLRGLAVGDALGARYSEPGSFPLLARRELPPAPWRWTDDTEMAASVVAVLAAHGRVEQDALAASFAGRQNAGGPRGYGRTVNRILRQVRDGGDWRRLAAALFDGQGSWGNGAAMRVAPLGAWYAGDVQEAVRQAEISSYVTHQHREAVTGCMAVAAAAALAADPPGDAAARPGDTSGPDGAALLDQVIALVPRSAVAQGLRRARDMLDYDDVATVAAVLGNGRRSTAHDTVPFALWSAARHLGDFAGAFWATVQAGGDVDTTCAIVGGVLAGAAAGAPPAEWVRHVEPLPEWVPAATDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NHY4</accession>
    <name>A0A0F7NHY4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_19005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020219.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_19005"/>
    <dbReference type="EnsemblBacteria" id="AKH86888">
        <property type="protein sequence ID" value="AKH86888"/>
        <property type="gene ID" value="AA958_19005"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_19005"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3990"/>
    <dbReference type="OrthoDB" id="1635062at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032584">
        <property type="entry name" value="DUF4913"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16259">
        <property type="entry name" value="DUF4913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="183" mass="19334" checksum="4913891E411C8587" modified="2015-07-22" version="1">MQQSQQQAQQLDRLASAPPSGPGASPFAAFGMPGLGGPPAAPPEPRPILELDGQEREDELDALSDWVDDFLLPVYGAEVTTAAPWCLQWQEHDDVVAWLHALWLAYQQHKEPDAGLAGLFVWHRDFLTHAVAAIRAPGGPLSACMTSPDRPAHRILPGPAPSARTAASAADRARPAGADGAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NIJ5</accession>
    <name>A0A0F7NIJ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aminotransferase class III</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_28555</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020483.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_28555"/>
    <dbReference type="EnsemblBacteria" id="AKH87088">
        <property type="protein sequence ID" value="AKH87088"/>
        <property type="gene ID" value="AA958_28555"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_28555"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6016"/>
    <dbReference type="OrthoDB" id="1322538at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1 2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH87088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="408" mass="42920" checksum="EAF12AD4D40214CC" modified="2015-07-22" version="1">MALYYAEPIEITHGEGRHVWDAEGNRYLDFFGGILTTMTAHALPEVTKAVAEQAGRILHTSTLYLNRPMVELAERIAQLSGIPDARVFFTTSGTEATDTALLLASTYRRSNQVLAMRNSYHGRSFTAVGITGNRAWSPTSLSPLQTLYVHGGIRTAGPFADLDDAAFIDACVADLRDMLSQTRGVAALIAEPVQGVGGFTSPPDGLYAAFREVLAEEGILWITDEVQSGWGRTGDHFWGWQAHAGNGPPDMLTFAKGIGNGTSIGGVVARAEIMNCLDANSLSTFGGSPVTMAAGLANLGYVLEHDLQGNARRVGGLLIERLRAAAAGLASVREVRGRGLMIGIELATPGHAAAVLEHARAGGLLVGRGKAGETLRIAPPLSLTVAEAEEGAAVLERALHAADAETAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NIZ8</accession>
    <name>A0A0F7NIZ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_15220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020087.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_15220"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <sequence length="113" mass="12741" checksum="224B114487D59A91" modified="2015-07-22" version="1">MDSPSADSVRKGVADLEGYLLWQAETEKARAAAEAFTAGLDWLTAGQRAEVLALYTRTELDRSRASVTHIARRARELREEYQARYDRLRRRAVAWCLALGAVAVFLLCLARTR</sequence>
</entry>
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        <lineage>
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            <authorList>
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">CNQ-509</strain>
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        <property type="gene ID" value="AA958_19405"/>
    </dbReference>
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    <dbReference type="PATRIC" id="fig|444103.5.peg.4080"/>
    <dbReference type="OrthoDB" id="1681726at2"/>
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        <source>
            <dbReference type="EMBL" id="AKH86902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="161" mass="17294" checksum="FC582C9B2175638A" modified="2015-07-22" version="1">MTTCDTKLILNQAVTITGTRATGHRPHGDYTRLFDTYLAPFASDAERVFYLGGALGIDSLALAWLAETTAVQLVVVVPGTLAQQPAEARSAVARHRARITEIVELRAAALNTAAYHARNRYMVDRSGMTIGFPHAGGAGSGTWQTLDYTAELGKPRLIVPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
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    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
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        <lineage>
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    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8 9">CNQ-509</strain>
        </source>
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    <dbReference type="EnsemblBacteria" id="AKH87007">
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            <end position="512"/>
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        <source>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH87007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="512" mass="53044" checksum="774007B7D29371E1" modified="2015-07-22" version="1">METRSAAPAGGPGSEALGDPRRWLILAVICTAYLMVGLDLTVMNLALPSAQEALEFSDSDRQWIVTAYALPFGSLLLFSGRLSDIIGRKESFLIGLTGFAGASAVGGAATNFEMLVTARACQGAFASMLAPACLALLATTFHDPKEKAKAFGIYSAVAASGAGLGLILGGALVSALNWRWCMYVNLVFAVVAFAGSVMLMQRETRTGAKLDVPGVVLASGGMFCLVYGFANAADEGWGTTSTWGVLALGGVLLLVFAFSQTRAANPLLPPRILLDRNRGGAYFTVLLVGTGMFGVMLFLIYYMQTNLDYSAITSGVALLPMVVCTTVGASAGAIKLMPTYGPRPLVTFGLVLSALGMAWLTVIGVDSGYVTHLLGPLMVVGLGMGFIYAAALRTGTSGVEPRDAGIASACVNTGQQLGGAVGTALLNTIAATATGNWLESNVQGQPSQSQLDLAAIDGYTTVFWWCTALFAIGAVVSGLLLRGGPLPTPAEEPAEEKADGEPEELSEETKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A097H0Z2</accession>
    <name>A0A097H0Z2_9ACTN</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="3" type="ORF">AA958_29970</name>
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    <organism evidence="2">
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        <lineage>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="ChemBioChem" volume="15" first="2385" last="2392">
            <title>A Membrane-Bound Prenyltransferase Catalyzes the O-Prenylation of 1,6-Dihydroxyphenazine in the Marine Bacterium Streptomyces sp. CNQ-509.</title>
            <authorList>
                <person name="Zeyhle P."/>
                <person name="Bauer J.S."/>
                <person name="Steimle M."/>
                <person name="Leipoldt F."/>
                <person name="Rosch M."/>
                <person name="Kalinowski J."/>
                <person name="Gross H."/>
                <person name="Heide L."/>
            </authorList>
            <dbReference type="PubMed" id="25224759"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CNQ-509</strain>
        </source>
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    <reference evidence="3 4" key="2">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIT42136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH85750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="171" mass="17521" checksum="1E67B2A5FA9CFBEA" modified="2015-01-07" version="1">MLGVFSTGLLLGALLSATVLWLASGLAAPVPADWRAGATAALGLLAVARDAGVLRLRLPQNARQVPQDVLQRHLARGALQFGFEMGTGVRTYVSASLPYALALGVLLANDAGVALAAGLGFALGRAATPALRFASGTGEEWDDRLLTRLPLLRLGAATVATAAWAVLALRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
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                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
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        <property type="entry name" value="Bi_nuclease_dom"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BFN" evidence="1">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="145" mass="15745" checksum="DC0FAFF9E0818D2C" modified="2015-07-22" version="1">MPSNQPIVLLREVGGDRYLPIWIGPGEATAIAFAQQGMTPARPLTHDLFKNVLDAVGQELSEVRITDLREGVFYAELVFSGGAEVSARPSDAIALALRTGTPIYGSEGVLNDAGISIPDEQEDEVEKFREFLDQITPEDFGTNPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-02-10" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MYS2</accession>
    <name>A0A0F7MYS2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PHB depolymerase esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_00450</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH80886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014252.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH80886">
        <property type="protein sequence ID" value="AKH80886"/>
        <property type="gene ID" value="AA958_00450"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_00450"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.106"/>
    <dbReference type="OrthoDB" id="1195966at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010126">
        <property type="entry name" value="Esterase_phb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10503">
        <property type="entry name" value="Esterase_PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01840">
        <property type="entry name" value="esterase_phb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002518972" evidence="3">
        <location>
            <begin position="35"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH80886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="328" mass="33755" checksum="E89E1889314BAC3E" modified="2015-07-22" version="1">MAVRDRARARPRAVLFALFALVAGALAAPANASAADLTRVTGFGSNPGNLAMYAYVPDGLPAGAPLVLALHGCTQSASDYHGHSGWAELADAHGFAVVYPQTTSVNNASSCFNWFQSGDTARGQGEALSVKQMADHATGLYGTDPDRVYVTGLSAGGAMTAGLLAAYPDVFAGGSIAAGIPAGCARSLVDAYTCMYVSAGKTPQQWGDLARAPSGGWSGPWPRVAIWHGTGDTTVVPANAVESRDQWTDVWGTGQTPAETTTLPGGTTRASYKDASGRSVVETYTISGMGHGLPVDPGTAAGQCGTTGTYYPDRICAGYYTAQFWGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MYT2</accession>
    <name>A0A0F7MYT2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Methionine ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_03515</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014763.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_03515"/>
    <dbReference type="EnsemblBacteria" id="AKH81405">
        <property type="protein sequence ID" value="AKH81405"/>
        <property type="gene ID" value="AA958_03515"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_03515"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.742"/>
    <dbReference type="OrthoDB" id="1058434at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033232">
        <property type="term" value="F:ABC-type D-methionine transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03258">
        <property type="entry name" value="ABC_MetN_methionine_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026253">
        <property type="entry name" value="ABC_MetN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041701">
        <property type="entry name" value="MetN_ABC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018449">
        <property type="entry name" value="NIL_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43166:SF5">
        <property type="entry name" value="PTHR43166:SF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09383">
        <property type="entry name" value="NIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00930">
        <property type="entry name" value="NIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="4 6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="2"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH81405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="340" mass="36363" checksum="CDD3936B7757DAC2" modified="2015-07-22" version="1">MITVRDLKKVYRSRGRGTAALDGVDLRVREGEVFGVVGRSGAGKSTLIRCINLLERPDSGTVTVAGQDLTALTGRELRAARTRIGMIFQHFNLLSARTVQDNVELPLEILGLSGQERARKALELLDLVGLADRARAYPAQLSGGQKQRVGIARALAGEPQVLLSDEATSALDPETTRSVLELLRELNRELGLTVLLITHEMDVVKAVCDSAALMRAGRITESGTLDELLATPGSEIAAQLFPVGGEAYGSESTIVDITFHGDARGRPVISHLSRTYNLDVSILGAAMDTVGGRQVGRMRIELPGPYEENVVPLGFLREQGLQIDPVGVDAAGLPALESAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MZ16</accession>
    <name>A0A0F7MZ16_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">8-amino-7-oxononanoate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_00925</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH80966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014332.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_00925"/>
    <dbReference type="EnsemblBacteria" id="AKH80966">
        <property type="protein sequence ID" value="AKH80966"/>
        <property type="gene ID" value="AA958_00925"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_00925"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.205"/>
    <dbReference type="OrthoDB" id="479874at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="3">
        <location>
            <begin position="34"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH80966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="380" mass="38371" checksum="FA4ADF5B9CA7956C" modified="2015-07-22" version="1">MPRHAFDWIDAQAEERRRAGLVRTLRPRAHDAPLLDLCGNDYLGLVRHPEVTAAAAASARRWGAGSTGSRLVSGSTALHAELEADLADFCGFEAALVFSSGYGANLAAVTALSDRGTLVVSDAGNHASLIDGCRLSRADVAVVPHADAEAVAKALDGFAGRTLAVSDGVFSVDGDAADLPALAATCRAYGAGLLVDDAHGFGVLGAGGRGSLHAAGLAGAADVVATVTLSKALGSQGGAVLGPTRVIEHLVNTARTFIFDTGLAPAAAGAAQASLRLLRREPERAAAARRVAAALHGGLTAAGLTAVRPDAAVVSVRAPAPEAAVAWAAACREAGVAVGCFRPPSVPDGISRLRLTARADLTEEQVDTAIETVVRTAPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MZ49</accession>
    <name>A0A0F7MZ49_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Nuclease SbcCD subunit D</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">sbcD</name>
        <name evidence="10" type="ORF">AA958_01135</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'-&gt;5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 7">Heterodimer of SbcC and SbcD.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the SbcD family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014366.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_01135"/>
    <dbReference type="EnsemblBacteria" id="AKH81001">
        <property type="protein sequence ID" value="AKH81001"/>
        <property type="gene ID" value="AA958_01135"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_01135"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.250"/>
    <dbReference type="OrthoDB" id="1831911at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00840">
        <property type="entry name" value="MPP_Mre11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041796">
        <property type="entry name" value="Mre11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004593">
        <property type="entry name" value="SbcD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026843">
        <property type="entry name" value="SbcD_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12320">
        <property type="entry name" value="SbcD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00619">
        <property type="entry name" value="sbcd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="7" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6 7 10" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="8">
        <location>
            <begin position="1"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="SbcD_C" evidence="9">
        <location>
            <begin position="267"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AKH81001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="389" mass="41196" checksum="03975B674F6EBCAD" modified="2015-07-22" version="1">MRFLHTSDWHLGRSFHRVSLLDAQAAFLDHLVAVVAERGVEAVFVAGDVYDRAVPPLAAVELFDRALHRLGALGVPVVMISGNHDSARRLGVGAGLLDRAGVHLRTDPAGVGEPVLLRDAAGDVACYGLPYLEPALVREEFATPRGGHTAVLSAAMDRVRADLAARPAGTRSVVLAHAFVTGGQVSDSERDITVGGVASVPASVFAGVDYVALGHLHGCQTLAERVRYSGSPLAYSFSEAAHRKSTWLVDLDAAGAVTAERIDAPVPRPLARLHGRLADLLADPALTPLEHAWVEATLTDTARPHEPMARLAERFPHVVSLAFAPESADGTAAAASYADRLKGRDDRQIAEDFVAHVRPGATATAGERAVLHAAFDAVRAADAREERAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N083</accession>
    <name>A0A0F7N083_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Elongation factor P</fullName>
            <shortName evidence="7">EF-P</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">efp</name>
        <name evidence="11" type="ORF">AA958_03150</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Protein biosynthesis; polypeptide chain elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7 8">Belongs to the elongation factor P family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014700.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_03150"/>
    <dbReference type="EnsemblBacteria" id="AKH81341">
        <property type="protein sequence ID" value="AKH81341"/>
        <property type="gene ID" value="AA958_03150"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_03150"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.671"/>
    <dbReference type="OrthoDB" id="1260763at2"/>
    <dbReference type="UniPathway" id="UPA00345"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04470">
        <property type="entry name" value="S1_EF-P_repeat_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05794">
        <property type="entry name" value="S1_EF-P_repeat_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00141">
        <property type="entry name" value="EF_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015365">
        <property type="entry name" value="Elong-fact-P_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020599">
        <property type="entry name" value="Transl_elong_fac_P/YeiP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013185">
        <property type="entry name" value="Transl_elong_KOW-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001059">
        <property type="entry name" value="Transl_elong_P/YeiP_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013852">
        <property type="entry name" value="Transl_elong_P/YeiP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011768">
        <property type="entry name" value="Transl_elongation_fac_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30053">
        <property type="entry name" value="PTHR30053"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01132">
        <property type="entry name" value="EFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08207">
        <property type="entry name" value="EFP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09285">
        <property type="entry name" value="Elong-fact-P_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005901">
        <property type="entry name" value="EF-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01185">
        <property type="entry name" value="EFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00841">
        <property type="entry name" value="Elong-fact-P_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00038">
        <property type="entry name" value="efp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01275">
        <property type="entry name" value="EFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7 11" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="6 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EFP" evidence="10">
        <location>
            <begin position="68"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Elong-fact-P_C" evidence="9">
        <location>
            <begin position="130"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AKH81341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="188" mass="20595" checksum="C91B69AA11DD2854" modified="2015-07-22" version="1">MATTNDLKNGLVLKLDGDQLWSVVEFQHVKPGKGPAFVRTKLKNVLSGKTVDKTFNAGVKVETANVDRRDMQFSYKDGEYFVFMDMETYDQVHIDPKTVGDTANYLLEGFDTTVALHEGTPLYVELPAAVELTIAQTDPGVQGDRSTGGTKPAELETGFSIQVPLFITTGEKIKVDTRSGEYLGRVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0A8</accession>
    <name>A0A0F7N0A8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Translocation protein TolB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_07255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015405.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH82055">
        <property type="protein sequence ID" value="AKH82055"/>
        <property type="gene ID" value="AA958_07255"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_07255"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1520"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="PD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008557">
        <property type="entry name" value="PhoX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05787">
        <property type="entry name" value="DUF839"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519007" evidence="1">
        <location>
            <begin position="34"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="385" mass="40463" checksum="F09838A3B638A27B" modified="2015-07-22" version="1">MERRSFLRAVTAGTGAVAVTGGLWHAAATPAAAAAADSPYGPLLAPDANGLALPQGFTGRVVARSTRAVGGITWHGAPDGGACFPDGDGWIYVSNSELPLIGGVSALRFGPDGTVTAARRILDGTNLNCAGGATPWNTWLSCEETYRGKVYETDPYGNRSASSYGAMGRFKHEAAACDTDRRVVYLTEDEDDGCFYRFTPASWGAWGALSSGRLDVLCDAGGGAVEWREVPDPDAPWPWEQTRAQVDEALHFDGGEGCYYSPQAGVCYFTTKGDNRVWAYDAGANALAVVYDADEPLGTVDNITGRAGGDLYVAEDGGNMEINIITPAGTVAPVVRIDGHPESEITGPAFSPDGSRLYFSSQRGESGFVAGTDGVTYEVRGPFRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0T3</accession>
    <name>A0A0F7N0T3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0434 protein AA958_08310</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_08310</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0434 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015585.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_08310"/>
    <dbReference type="EnsemblBacteria" id="AKH82235">
        <property type="protein sequence ID" value="AKH82235"/>
        <property type="gene ID" value="AA958_08310"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_08310"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1753"/>
    <dbReference type="OrthoDB" id="1834382at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01187">
        <property type="entry name" value="UPF0434"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005651">
        <property type="entry name" value="Trm112-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03966">
        <property type="entry name" value="Trm112p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="54"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH82235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="71" mass="7819" checksum="B272231C6FC85BD0" modified="2015-07-22" version="1">MNPEDPLLKILVCPLDKGPLTLLDSGDALYNPRLRRRYPVRDGIPQLLPASGEAVSDEEHERITGGPQSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0Z6</accession>
    <name>A0A0F7N0Z6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 13">Phosphoenolpyruvate-protein phosphotransferase</fullName>
            <ecNumber evidence="5 13">2.7.3.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 13">Phosphotransferase system, enzyme I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">AA958_01590</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>L-histidyl-[protein] + phosphoenolpyruvate = N(pros)-phospho-L-histidyl-[protein] + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:23880"/>
            <dbReference type="Rhea" id="RHEA-COMP:9745"/>
            <dbReference type="Rhea" id="RHEA-COMP:9746"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:29979"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:64837"/>
            <dbReference type="EC" id="2.7.3.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 13 16">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the PEP-utilizing enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.7.3.9" evidence="5 13"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014437.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_01590"/>
    <dbReference type="EnsemblBacteria" id="AKH81073">
        <property type="protein sequence ID" value="AKH81073"/>
        <property type="gene ID" value="AA958_01590"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_01590"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.349"/>
    <dbReference type="OrthoDB" id="467393at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008965">
        <property type="term" value="F:phosphoenolpyruvate-protein phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008279">
        <property type="entry name" value="PEP-util_enz_mobile_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018274">
        <property type="entry name" value="PEP_util_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000121">
        <property type="entry name" value="PEP_util_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023151">
        <property type="entry name" value="PEP_util_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036637">
        <property type="entry name" value="Phosphohistidine_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024692">
        <property type="entry name" value="PTS_EI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006318">
        <property type="entry name" value="PTS_EI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008731">
        <property type="entry name" value="PTS_EIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036618">
        <property type="entry name" value="PtsI_HPr-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05524">
        <property type="entry name" value="PEP-utilisers_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00391">
        <property type="entry name" value="PEP-utilizers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02896">
        <property type="entry name" value="PEP-utilizers_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000732">
        <property type="entry name" value="PTS_enzyme_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47831">
        <property type="entry name" value="SSF47831"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52009">
        <property type="entry name" value="SSF52009"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01417">
        <property type="entry name" value="PTS_I_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00742">
        <property type="entry name" value="PEP_ENZYMES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00370">
        <property type="entry name" value="PEP_ENZYMES_PHOS_SITE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0418">Kinase</keyword>
    <keyword evidence="13 16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 13 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="20" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="13 20" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 13" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PEP-utilisers_N" evidence="19">
        <location>
            <begin position="6"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers" evidence="17">
        <location>
            <begin position="150"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers_C" evidence="18">
        <location>
            <begin position="253"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="PEP binding" evidence="15">
        <location>
            <begin position="438"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="14">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="14">
        <location>
            <position position="486"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="415"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="439"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="449"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00033235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR000732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000732-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000732-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000732-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF05524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="AKH81073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="556" mass="56958" checksum="BB01B91525438C96" modified="2015-07-22" version="1">METTLQGVGVSHGVAIGEARHMGTAVLEPPAKQIPAAEAPREQERVRKAVEAVAADLVARGNLAGGEAQAVLEAQAMIAQDPELAADVERRIAVGSSAERAAYDAFAAYRELLAGAGEYMAGRVADLDDVRNRIVARLLGVPMPGVPDSDEPYVLIARDLAPADTALLDPSLVLGFVTEEGGPTSHSAILARALGVPAVVALPGAVELAEGTVVAVDGSTGEVFVAPGPEKRAEMEQMAAERKAALAAASGPGATSDGHEVPLLANIGGPADVPAAVAAGAEGVGLFRTEFLFLDDSRTAPSEQAQITAYRQVLEAFPEGRVVVRVLDAGADKPLEFLTPADEPNPALGVRGLRSLLAHPDVLRTQLTALSKAAAGLPVYLEVMAPMVADRQDAADFAAACRSAGLPAKAGAMVEIPAAALRARAILREVEFLSLGTNDLAQYAFAADREVGAVSRLQDPWQPALLDLVSFAAEGAKAEGKSCGVCGEAASDPLLACVLTGLGVTSLSMGAAAIPYVRATLAKHTLAQCERAASAARAADTAEEAREAARAVLSGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N195</accession>
    <name>A0A0F7N195_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 13">UvrABC system protein B</fullName>
            <shortName evidence="13">Protein UvrB</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Excinuclease ABC subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">uvrB</name>
        <name evidence="18" type="ORF">AA958_05780</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 13">The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11 13">Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="13">The beta-hairpin motif is involved in DNA binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the UvrB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015144.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_05780"/>
    <dbReference type="EnsemblBacteria" id="AKH81791">
        <property type="protein sequence ID" value="AKH81791"/>
        <property type="gene ID" value="AA958_05780"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_05780"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1210"/>
    <dbReference type="OrthoDB" id="95696at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009380">
        <property type="term" value="C:excinuclease repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009381">
        <property type="term" value="F:excinuclease ABC activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00204">
        <property type="entry name" value="UvrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001943">
        <property type="entry name" value="UVR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036876">
        <property type="entry name" value="UVR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004807">
        <property type="entry name" value="UvrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041471">
        <property type="entry name" value="UvrB_inter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024759">
        <property type="entry name" value="UvrB_YAD/RRR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24029">
        <property type="entry name" value="PTHR24029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12344">
        <property type="entry name" value="UvrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17757">
        <property type="entry name" value="UvrB_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46600">
        <property type="entry name" value="SSF46600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00631">
        <property type="entry name" value="uvrb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 13" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 13" id="KW-0228">DNA excision</keyword>
    <keyword evidence="9 13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 13" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="4 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="35"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="438"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="domain" description="UVR" evidence="15">
        <location>
            <begin position="665"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="621"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Beta-hairpin" evidence="13">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="48"/>
            <end position="55"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00026033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="AKH81791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="710" mass="79729" checksum="D6B69BD6C42EF00C" modified="2015-07-22" version="1">MRPVTDIERTMAPFEVVSPYQPNGDQPAAIDELERRIRAGERDVVLLGATGTGKSATTAWMVERLQRPTLVLAPNKTLAAQLANEFRELLPNNAVEYFVSYYDYYQPEAYVPQTDTYIEKDSSINEEVERLRHSATNSLLTRRDVIVVASVSCIYGLGTPQEYVDRMVPLKVGEEIDRDQLLRRFVDIQYTRNDQAFTRGTFRVRGDTIEIFPVYEELAVRIEMFGDEIEALSTLHPLTGEVMSEDDGLYVFPASHYIAGPERMAKAVTGIETELGEQLGTLEKQGKLLEAQRLRMRTTYDLEMLQQIGTCSGVENYSLHMDGRETGSPPHTLLDYFPEDFLLVIDESHVTVPQIGAMYEGDASRKRTLVDHGFRLPSALDNRPLKWEEFLERIGQTVYLSATPGPYELSRGDGFVEQIIRPTGLVDPEVVVKPTEGQIDDLVHEIRTRAEKDERVLVTTLTKKMAEDLTDYFLELGIQVRYLHSDVDTLRRVELLRELRAGEYDVLVGINLLREGLDLPEVSLVAILDADKEGFLRSGTSLIQTIGRAARNVSGEVHMYADKITPGMEKAIDETNRRRAKQIAYNEEHGIDPQPLRKKINDIVAQIAREEVDTEALLGSGYRSTKPDAAAKAPVPELRQKTKPARRGEAEAGAAPTETPAADLAAQIEDMTARMRSAAGDLQFEVAARLRDEVAEMKKELRQMKEAGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N1R4</accession>
    <name>A0A0F7N1R4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_03065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014687.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_03065"/>
    <dbReference type="EnsemblBacteria" id="AKH81324">
        <property type="protein sequence ID" value="AKH81324"/>
        <property type="gene ID" value="AA958_03065"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_03065"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.654"/>
    <dbReference type="OrthoDB" id="1548885at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="170" mass="18020" checksum="D952FA2630F5DEBE" modified="2015-07-22" version="1">MADHASHDAQARASLQLLVRDIERVRRQVDALRTLTAQLGNVYRPRRTGPSAGFVVYGRAPAPTVRLAQELRDSVETLVTAAVDFDRSLGFSWDAVGSALGVTKQAVHRRYGTRRAQQAPREAGSAEAAGAPTGESRLPSGTLPVVPAARPAPGTTTPTQQTDAVAITQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N1U8</accession>
    <name>A0A0F7N1U8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">Bacterioferritin</fullName>
            <ecNumber evidence="5">1.16.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AA958_06670</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Iron-storage protein, whose ferroxidase center binds Fe(2+) ions, oxidizes them by dioxygen to Fe(3+), and participates in the subsequent Fe(3+) oxide mineral core formation within the central cavity of the protein complex.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>4 Fe(2+) + 4 H(+) + O2 = 4 Fe(3+) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11148"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.16.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homooligomer of 24 subunits, arranged as 12 dimers, that are packed together to form an approximately spherical molecule with a central cavity, in which large amounts of iron can be deposited.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 7">Belongs to the bacterioferritin family.</text>
    </comment>
    <dbReference type="EC" id="1.16.3.1" evidence="5"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015298.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_06670"/>
    <dbReference type="EnsemblBacteria" id="AKH81946">
        <property type="protein sequence ID" value="AKH81946"/>
        <property type="gene ID" value="AA958_06670"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_06670"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1391"/>
    <dbReference type="OrthoDB" id="1890523at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004322">
        <property type="term" value="F:ferroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:cellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00907">
        <property type="entry name" value="Bacterioferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002024">
        <property type="entry name" value="Bacterioferritin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009040">
        <property type="entry name" value="Ferritin-like_diiron"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008331">
        <property type="entry name" value="Ferritin_DPS_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00210">
        <property type="entry name" value="Ferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002560">
        <property type="entry name" value="Bacterioferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00601">
        <property type="entry name" value="BACFERRITIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
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        <ligand>
            <name>Fe cation</name>
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            <label>1</label>
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            <position position="52"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <note>ligand shared between dimeric partners</note>
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        <ligandPart>
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        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AKH81946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
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    </evidence>
    <sequence length="158" mass="18538" checksum="1E768CA4C886519A" modified="2015-07-22" version="1">MQGDHEVLEFLNEQLTAELTAINQYFLHAKMQENFGWTKLAKYTRSESFDEMKHAEILTDRILLLEGLPNYQRLFHVRVGQTVTEMFQADRQIEVEAIDRLRRGIELMRAKSDITSANIFEAILEDEEHHIDYLDTQLDLIEKLGEALYIAQQIEQPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-12-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2D7</accession>
    <name>A0A0F7N2D7_9ACTN</name>
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        <submittedName>
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    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
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        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
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        <location>
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            <end position="63"/>
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        </source>
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        </source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="352" mass="37767" checksum="CF33E1662ABD405B" modified="2015-07-22" version="1">MSPGRVTLADVARRAGVSPTTASLVLSGRGRELRISEGVEQKVLKAADELQYRPNIVSVGLRTGKSRTIGFVSDTVATSRLAGDMIKGALEAARERGVMLFIGETEGETDLEGGLLQAMQDRQVDGIILASMFTRAVQVPEGLASSPAVLLNAVAEQASTLPSVLPDEVEAGRAAARVLLDAGHRDGIHVIGAGPRVRDVPPEALAGVERLTGIREVLSRAKVELASGRVCADWQPEHGYEATRELLGHVHPRALICLNDRIALGAYQALDDHGLKVPADVSVISFDDHPIATWIRPKLTTVALQHYELGRKAVDVLFTEIERHHKGVGPDQRTHRVPMPVRMRESVAPPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
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    </gene>
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        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">CNQ-509</strain>
        </source>
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    </dbReference>
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    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="121"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="150"/>
            <end position="183"/>
        </location>
    </feature>
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            <end position="365"/>
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        </location>
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        </location>
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            <end position="1276"/>
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            <end position="1324"/>
        </location>
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        <location>
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            <end position="1348"/>
        </location>
    </feature>
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        <location>
            <begin position="1360"/>
            <end position="1380"/>
        </location>
    </feature>
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        <location>
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            <end position="32"/>
        </location>
    </feature>
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            <begin position="1416"/>
            <end position="1566"/>
        </location>
    </feature>
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        <location>
            <begin position="11"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="1566" mass="164117" checksum="91D71CA2CE799133" modified="2015-07-22" version="1">MTSTLPAQPATPGRPYSPPPPSGPAGARPPESRRSWRWPLGFWAFAFVAWLIPSAGKTTFETKLGVVVDPWKFAGDLGELWHDQNGFGGIHDQYFGYAFPMLPYYLLTDVAQMPTWLAERLWLSLVVTAAFWGALKLADRLGFGTPGTRVLGAVAYALWPVFTIIVGSTSAGALPGAILPWVLLPLLDERLTPRVAAARSALIIPFMGGVNAASTLAALLPALLYVCTRTGSRRTRLLAWWLPGVLLACLWWIVPLLLLGIYGENFLPFIETAHNTTTTMSATEVLRGTGNWVAYLNFGEAWLPGGWTVATGWLPILSSVLAAGLGLAGLARRDLPERRWLVLTVMVVALVTLAGYGGALGAPFSGGVQDALDSWLSPFRNIYKFQPGLALALALGLAHIVAVAAERRGTRANPRRSAWVPAIAALVVLPGLVLPYANGDVLQPGAFDKLPKHWEQTADWLEEYSPDSRALVVPATAHGTYEWGKPIDQPLDVLAESRWAQRDYVPFGTAGSRRAMDAVDQALMTGGEVPGLQAFLARAGLHYVVVRNDLDPDQVGYVPPTTVKQTLTSSGYEKVAEFGPELTGGRIPEGTPLQIEGLFSRQRAVEIYQPADGEDLRPGPAGTLNAAGTAVLSGGPESLLPLSADPGWQGRPAVLAGDAHPGVEEPALKVQADGLRRADTRFGVVNNNTSYTYTEDEKNPEESLQDPGDEPRMIVPEKGTEHQTTAVLDGAAAVTASTSGNWMFHLPQFDPVNAFDGVPQTGWAEGNPDTSKGEWLQIDFTEPTNLEGTLDLTPLPGAGVRPEPVEVEVETPRGSEVSTLQAGGRTQTVRSPEGQADWLRITIRKTEGARTGFAGAGFAEVEIPGVSPVSRQLRLPADAKQVAADAEQISLHRGSDLGGLNPAAAETGLQRRFESGEGEYTVTGRALPVQGRELDALLDDLSALPEERINVTAGSTMPLSPQLSPRNLVDEDLTTAWIAGADESLTLTWPEATEISEFVLAPAGGLSARPTEVEVSTPTGAQTVGVDANGWVRIPPVTTDRIDIKVTETESLSVHNPFADRDVQLPVGLTEVYVPALGEDAEEDLRTEPVKKDEPFELECGSGPVVSVDGELLNTRAEGTLGDLVDRRPVDIELCPGDGETAGPVELAAGRHAVAAGDGEALAVTDLTLTRGEPAAAAAGRDVEATDWAGDERAVTVGEGQDAYLTTYENYNDGWKATLDGEELESVRLDGWQQGFLVPADKSGEVKLEYKPAVWYDAGIFAGVAAILALLGLAFVRAGRREVVVAEPAPPAPGWVLGALVLTAVVAVVAGPYALIVPALALLARTRAGLLAPLALVAMAGAGVAALTGAGEAVRMDEGAFSGVAQALAVLALAAALVTAERPEPAGPETGYGPDVDPEAETAAFPAYGAGVPAAGAAGAAGGPPPGPGGPPGRTAVAAEPGAGAAPQAEPDRPTQRFWRRRSAGASAAAAAAAESGADRTPALGTERAAADDSATPPLGTAQDEPRDAFVPKPPIPLSGTAEAPDAADPAGPADDVEDTPPADAPPADTPPDDGTPADRREENGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N300</accession>
    <name>A0A0F7N300_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_05475</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015092.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_05475"/>
    <dbReference type="EnsemblBacteria" id="AKH81738">
        <property type="protein sequence ID" value="AKH81738"/>
        <property type="gene ID" value="AA958_05475"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_05475"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1148"/>
    <dbReference type="OrthoDB" id="1510342at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="40"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="164"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="264"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="96"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH81738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="302" mass="33112" checksum="1C8C8D857899EDE9" modified="2015-07-22" version="1">MSTAPTALAAPPRARGAAPAPPARRGRRRRRRAYDEVPRWQIWLPLGLYLLFTLVPFYWMLLFALRPAGSTSLVPWPMTFEHFDKVWTERSFGTFFQNSMLVGVATLVMTTGVALAGGYALARFDFRIKKAFLLGLLCSQFIPGALMLVPLFEIFRSLQMINSLGSVVIAETVFQLPLSLILISTFIKNVPYALEEAAWVDGCGRFRAFCAVVLPLLRPGLVAVGSFAFVHSWNHFLFALMFLSEQDKQTIPVGLNTLIGADSVDLGALAAGGVIAAVPVVIVFAFIQRWLITGFSAGAVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N351</accession>
    <name>A0A0F7N351_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_13480</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016405.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_13480"/>
    <dbReference type="EnsemblBacteria" id="AKH83075">
        <property type="protein sequence ID" value="AKH83075"/>
        <property type="gene ID" value="AA958_13480"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_13480"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2835"/>
    <dbReference type="OrthoDB" id="1827824at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="5">
        <location>
            <begin position="161"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="379"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH83075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="424" mass="44909" checksum="5D3731E4500BBED6" modified="2015-07-22" version="1">MDVNAAVAAAAAIAGLCTGVIAVLAFRWSEREQARPTRTSLHTDAVLPPGVDTVLSVLRSSAVVLDEDDAVVKASSAAYALGLVRGGRLAVEPMLAMARDTRRDGEIRQVELDLPRRSGRGEALAVSARVAPLGSRLVLLLVEDMTEARRIEAVRRDFVANVSHELKTPVGALSLLSEAVMDAADDPEAVERFAGRMQGEATRLTSLVQELIDLSRVQNDDPLEDAEPVRADELVGEAIERCRQQAGAKQITIATGGTAGLHVWGNRGQLAAALGNLVENAVNYSPARTRVGIAARRLPAQGGDLIEIAVTDQGIGISEKDRERVFERFYRVDPARSRATGGTGLGLAIVKHVAASHGGEVTVWSAEGQGSTFTLRLPEAARPKSGRPDTGRSGALIGPEDLDGEVRLRFDGTDAPDTAPEVIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3E7</accession>
    <name>A0A0F7N3E7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA polymerase sigma24 factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_10375</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015908.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH82566">
        <property type="protein sequence ID" value="AKH82566"/>
        <property type="gene ID" value="AA958_10375"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_10375"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2186"/>
    <dbReference type="OrthoDB" id="1469807at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="5">
        <location>
            <begin position="5"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="6">
        <location>
            <begin position="99"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH82566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="399" mass="42425" checksum="A031E1E1AA41ABE4" modified="2015-07-22" version="1">MNESLLRELVPEVIGVLVRRGADFAAAEDAVQDALVEAVRGWPEGDAPRDPKGWLITVAWRKFLDTVRAESSRRRREERVEAEPAPDGGGAVDDTLQLYFLCAHPSLTPASAVALTLRAVGGLTTRQIARAYLVPEATMAQRISRAKRTVSGVRFDQPGDLATVLRVLYLVFNEGYSGDVDLSAEAIRLTRQLAARTGAAVARRAAAGGEGAGAGGEEVAGLLALMLLHHARRPARTGADGRLVPLAEQDRGLWDTGLIAEGVGILQAALARDRLGEFQAQAAIAALHADAPTAAETDWVQIVEWYDELVRLTGSPVAGLNRAVAVGEADGARAGLAALAELDPSLPRYTAVAAYLHERDGDTETAAGLYAQAARSAPNIPERDHLTRQAARLNARLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3K6</accession>
    <name>A0A0F7N3K6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_03375</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_03375"/>
    <dbReference type="EnsemblBacteria" id="AKH81382">
        <property type="protein sequence ID" value="AKH81382"/>
        <property type="gene ID" value="AA958_03375"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_03375"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.717"/>
    <dbReference type="OrthoDB" id="920264at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH81382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="385" mass="40485" checksum="950F460B1E1AB469" modified="2015-07-22" version="1">MYRQPPEPDPAHTDPAVLGALLARHGWRRHGGSTGRYARFTPPGDAPGGAGVLVPADRAFPDCTDLLAEALSALARSPEPSAPLVLTAVAVPSDEVSWEYGAGRRAGPARWADAERLSAAARAMLLAGALAARRPAGFHGARLRPHAARDVEQTLLGSGAHAARLTAFVPAPESRAVTTTLLRALRGTREAVDRHHTTGAMDDFDHAVGLGVCHELAEALTALVRGTDGVRIALAWAPAYPPPEGFAAAPEPTEFTPGDIPALQRAAVRYRSREPSLPVRLTAAVTRLSRTAATGRGRVRLRVLAGADVTEVRTSLGEEAYRVAGQAHLAGVPVRLSGMLESRGGFRRLTGASGVRPVPVADAEGDRLPKAHEHLDFCDEAYGDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3N9</accession>
    <name>A0A0F7N3N9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">F0F1 ATP synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_06910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015340.1">
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_06910"/>
    <dbReference type="EnsemblBacteria" id="AKH81989">
        <property type="protein sequence ID" value="AKH81989"/>
        <property type="gene ID" value="AA958_06910"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_06910"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1444"/>
    <dbReference type="OrthoDB" id="2029670at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH81989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="92" mass="9801" checksum="2AACAE6C87E600D4" modified="2015-07-22" version="1">MIVRIMGEGQVKLDDSHFAELDKLDDELLAEMEGGDEAGFRRTLGALLDAVRSLGAPLPADALEPSELILPGPDASLDEVREMLSDDGLIPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3P1</accession>
    <name>A0A0F7N3P1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_06740</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arsA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015310.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_06740"/>
    <dbReference type="EnsemblBacteria" id="AKH81958">
        <property type="protein sequence ID" value="AKH81958"/>
        <property type="gene ID" value="AA958_06740"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_06740"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1408"/>
    <dbReference type="OrthoDB" id="1225869at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025723">
        <property type="entry name" value="Anion-transp_ATPase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040612">
        <property type="entry name" value="ArsA_HSP20-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016300">
        <property type="entry name" value="ATPase_ArsA/GET3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10803">
        <property type="entry name" value="PTHR10803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02374">
        <property type="entry name" value="ArsA_ATPase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17886">
        <property type="entry name" value="ArsA_HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519208" evidence="3">
        <location>
            <begin position="20"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="ArsA_ATPase" evidence="4">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="ArsA_ATPase" evidence="4">
        <location>
            <begin position="79"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="ArsA_HSP20" evidence="5">
        <location>
            <begin position="369"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="46"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH81958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="437" mass="46125" checksum="E03EF44D2CEEF3AD" modified="2015-07-22" version="1">MRTLLVTGAAGAGRTTVAAATALRAARAGARVLLLTADREAGGLLTGAPEARVPGQRPAAEPAAERSAEAPPWTDPVRVGTGLWAARLRGAESATESLALWQERYEDTLDLLGATPLAAEELTPLPGSREFAVLRALVALYETGPADGDVSAAGDSAASGPWDLAVVDMPAAWETLRALALPEQLVRYLRRLLPAERQAARGLRPLLGRLLGAPVPAGRVYEAAARWEHRLETVREAAEAAGTRVRLVLEATPRGARELRRTRAAYALQGCAVEAVVANRVLPGGSDDAWYATLADEQHRVAKELAAELREAGARFCVLPHLGPEPKGPVALAVLAEAVAPPGARPAAIDPGDPAEVDDLLADEGVLLYRLPLPGVERGDLTLVRRGDELLVTAAGHRRALPLPAALRRCTITRAGLHEAELHIRFTPDPAVWPQPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3Q9</accession>
    <name>A0A0F7N3Q9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_07015</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015360.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_07015"/>
    <dbReference type="EnsemblBacteria" id="AKH82009">
        <property type="protein sequence ID" value="AKH82009"/>
        <property type="gene ID" value="AA958_07015"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_07015"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1468"/>
    <dbReference type="OrthoDB" id="630753at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001613">
        <property type="entry name" value="Flavin_amine_oxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00757">
        <property type="entry name" value="AMINEOXDASEF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amino_oxidase" evidence="4">
        <location>
            <begin position="20"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="293"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH82009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="478" mass="48900" checksum="872B1CED50B58ED3" modified="2015-07-22" version="1">MPHAAGSTDPVDVVVVGAGLAGLSAAQHLVGAGLDVTVLEADEQVGGRMTTDHVDGFRLDRSLQLLNTSYPELRRLPGLAEVPLCPLDGDVVVCGGGRRQRIGGSRGTGGAFTAASALASAARAPRGAVIDQAWLSTALARLATVPTARLLARPERRAADALAARALPPRMAAGFLRPLLVALLNDPALTTSSRSADLALRSFARGRLCLPAGGAATVPRKLAAGLPRGTVRTGVRAVSVSTTAVRTEEHGVLRCRSVLVATGARAAAGLLPGLRLPGFHPVTVLHHSAPVASLPGGDGPAEGEAGADGLPAGDGEARSAGVRGQIPGDLRQAALLVDAEEARGPVSHTAVVSGADASRAPRGRALVSSVVLGEEAGRPARVLDKSARRQLSELYGTSAFDWELVGAHHDPEAIPAMPAPHDLRRPVRVLCGLYVCGDHRDTSSPQGALHSGRRAARSLLRDFGLTPTTTTTAIPAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3V5</accession>
    <name>A0A0F7N3V5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_11225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016044.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_11225"/>
    <dbReference type="EnsemblBacteria" id="AKH82706">
        <property type="protein sequence ID" value="AKH82706"/>
        <property type="gene ID" value="AA958_11225"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_11225"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2365"/>
    <dbReference type="OrthoDB" id="623081at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="544" mass="58168" checksum="6733CE283E4A1995" modified="2015-07-22" version="1">MRITFLADPAATVEDGVVRGLAARHDVEFAADAGPAALRTLDADVLVIAAPGLVPAAVALAPARTLTVHRAPRPGHPPPPGAPELDALVVPAEADRAAYEAELGPAAPRLAAIPDDAHAADRWQALLTELAAIRDDEPRRQRDRADRAAFHRAATAPARPPRPLPPHPAPTAAELRRWEETVRTSGGGGGGRLVRAAGQWAEVRDDLLAADAYAANLRLAADALEAADVPYLLLRDPDDPDDPDGTDGTDGTDGTDGTDDPDGPAPRHRLAVDAGLRSRACRALAGAYPGQAVYAVSPRNPDVPVPAELLTAAGEPPALRLYRPYLTSGRTLRYGPGHGCDIEFWQRRHRGGAYTTPRAPTALGTTLPSLTPTAVLYVADRAFPTLREFVTEPRPPVDAVYTTTGPALRYSLRSLAMYAPWVRHTYLVAEAPPPWLDTARPGLTVVDRRHPLDALATHVLPLADDVFLGRALPAGRRTGPPRVESAGGHGPRRLDRLFVRRDTDVFCLRLHGTLPRGVQAFLEEYFPVPSPYERAGARGEGVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N414</accession>
    <name>A0A0F7N414_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_07540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015459.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH82109">
        <property type="protein sequence ID" value="AKH82109"/>
        <property type="gene ID" value="AA958_07540"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_07540"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1580"/>
    <dbReference type="OrthoDB" id="1268974at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003313">
        <property type="entry name" value="AraC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037923">
        <property type="entry name" value="HTH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02311">
        <property type="entry name" value="AraC_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51215">
        <property type="entry name" value="SSF51215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="176"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="276" mass="29355" checksum="A2AA0EAFA893D95C" modified="2015-07-22" version="1">MSGEGGGRSPGEYARWTRTPLGAGQSLYLMTACFTAHRYAPHAHHEFAVGVCTEGAEVIDYRGERIGARPGSIVVLGPGEAHTGGPAGDEGYAYRAFYPSMALLTDGACTDAHFAEPVIDDPALAAALRAAHVAVDRGAEPLEAESRLPWLLAALARRHGRARPAATAALGGGVARAIRDRLADELTDPPSLAAIGCDLGLSRYQVLRAFRDTMGMPPYAWLAQHRVERARGLLEAGHRPAEVAGLVGFADQAHLTRWFRRVLGATPAAYSRSVRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N483</accession>
    <name>A0A0F7N483_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PG_binding_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_07970</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015529.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_07970"/>
    <dbReference type="EnsemblBacteria" id="AKH82179">
        <property type="protein sequence ID" value="AKH82179"/>
        <property type="gene ID" value="AA958_07970"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_07970"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1681"/>
    <dbReference type="OrthoDB" id="2042114at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.101.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036366">
        <property type="entry name" value="PGBDSf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="SSF47090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="171"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="PG_binding_1" evidence="3">
        <location>
            <begin position="309"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH82179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="376" mass="38289" checksum="D8053A98088D5A4C" modified="2015-07-22" version="1">MIPRACRTCGEPPREDGGRGCACGAESGAEDGAEAGTEGRREPDRPLLRPYVMKAPGPVGGWDGEGAGAGGAAEGYGTEAAPPHGGTPEGYGPGAPSPDGSLAAPDSTFAAPYGPIGAAPEGPADADLGLFADDPAAPRAARDPYDADDPRDPYDPRRRGDRLAARRRRRLTLVLTVGGVVAALSVGLLGSGLFSDDGADDRALPKPDTITAVPTGGGTKPGPDDAHSGAPTAPADGDDPAEPSAGESDRTGSASAGPDDAPTERTEAGQVTAAPPDSGPSTPGDPDPGTTPEDPDPPPPPPTLREGDTGPEVVELQKRLIDAGYDNFLSDADGQYGFFTRRGVERFQRDNDIDGDERGVYGPETRRALESMTKEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4J5</accession>
    <name>A0A0F7N4J5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SLATT_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_08795</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015655.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_08795"/>
    <dbReference type="EnsemblBacteria" id="AKH82308">
        <property type="protein sequence ID" value="AKH82308"/>
        <property type="gene ID" value="AA958_08795"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_08795"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1853"/>
    <dbReference type="OrthoDB" id="1373594at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040688">
        <property type="entry name" value="SLATT_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18183">
        <property type="entry name" value="SLATT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="SLATT_2" evidence="3">
        <location>
            <begin position="20"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH82308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="212" mass="23090" checksum="296D4CA11E769647" modified="2015-07-22" version="1">MPGRETGTPEVRSRRGRRRDLGGRPFPAIALEATGGPQEILQELRAWAEREAEDAIEWYLADKRRKRLGSRIVSVLTILLAVGGTLIPLASVISGGPPQGWGYVLLALAAGCKGFDHFFGMSSGWMRDITAAHALRGALNDFRMAWAAEHLRAAADGALDPAALERRLALLTSLVEAVQRQVESETAEWLSDFRATAQQLQDNVVLPPGERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4M7</accession>
    <name>A0A0F7N4M7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH tetR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_16895</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016914.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_16895"/>
    <dbReference type="EnsemblBacteria" id="AKH83610">
        <property type="protein sequence ID" value="AKH83610"/>
        <property type="gene ID" value="AA958_16895"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_16895"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3555"/>
    <dbReference type="OrthoDB" id="2047542at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="14"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH83610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="245" mass="26269" checksum="CD18167EB6F09579" modified="2015-07-22" version="1">MTAAPHDIGRADARRNRTKVLAAASRAFDEHGTDISLGAIARQAGVGAGTVYRHFPSKEILLEAVLVRQVDDAVDAARRWAARADPVTAFFGFLLEVVDTSLGRKHACDALTAETNWPRPGLAASARRFRRALDELLRAAQQAGGVRTDVGADDVAALTVGCSTTRAAHRDRNGGARMARLALESLRSPGSVTEGQVFRDAPGALHAARRCEECGARLQARPSGRPARYCGATCRQRAHRRRLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4Y3</accession>
    <name>A0A0F7N4Y3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_17575</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017019.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_17575"/>
    <dbReference type="EnsemblBacteria" id="AKH83715">
        <property type="protein sequence ID" value="AKH83715"/>
        <property type="gene ID" value="AA958_17575"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_17575"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3700"/>
    <dbReference type="OrthoDB" id="1303819at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013519">
        <property type="entry name" value="Int_alpha_beta-p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01839">
        <property type="entry name" value="FG-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13517">
        <property type="entry name" value="FG-GAP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00191">
        <property type="entry name" value="Int_alpha"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="SSF69318"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51470">
        <property type="entry name" value="FG_GAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519256" evidence="4">
        <location>
            <begin position="36"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH83715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="493" mass="48844" checksum="B976EC72C10DB65F" modified="2015-07-22" version="1">MPRSRRTPTTATALAASLAVVAGAALAGGAAPAAAAPAEGAVAAPAKFHDDFNGDGYPDLVVAAPSGTVDGAARAGYVAVLYGSAGGLDTARRTVVSQSTAGVPGTSEAGDAFGATLASADVDRDGYADLAVGVTGEDLGGVADTGRTIVLYGSSGGLSGSGAQDLRPASLTEGNAYATGLAAGDWFHDGSTALAILSKDHLELYGGWGRARTPARAQAGHPFADFPQDFTPTGLVGGDFEGDGAADLVVTGRKWYLEYLQGHSLYLKGGGPEGYTRTEFAGGPVGVAGDIDKDGADDLAIGDPSVLEHGEYELSGGAVQVWYGAAGGPGSGQPEVWQQGSGGVPGAYEVEDRFGSDVSLGDVNGDGFLDLAVGAEGEAIGTGAGAGAVWLLRGSAGGLTTTGVQHFNQDTPGIPGTAEAGDLFGSDVRLHDPNRDGRSGLIAGAPGENAGQGFAWVLQARSSGLIADGSWNFSGASVGANGANARFPETIAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4Y7</accession>
    <name>A0A0F7N4Y7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase</fullName>
            <ecNumber evidence="7">2.7.7.60</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">4-diphosphocytidyl-2C-methyl-D-erythritol synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">MEP cytidylyltransferase</fullName>
            <shortName evidence="7">MCT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ispD</name>
        <name evidence="9" type="ORF">AA958_13460</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>2-C-methyl-D-erythritol 4-phosphate + CTP + H(+) = 4-CDP-2-C-methyl-D-erythritol + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13429"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:57823"/>
            <dbReference type="ChEBI" id="CHEBI:58262"/>
            <dbReference type="EC" id="2.7.7.60"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 2/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.60" evidence="7"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016402.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_13460"/>
    <dbReference type="EnsemblBacteria" id="AKH83071">
        <property type="protein sequence ID" value="AKH83071"/>
        <property type="gene ID" value="AA958_13460"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_13460"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2830"/>
    <dbReference type="OrthoDB" id="1836139at2"/>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00093"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050518">
        <property type="term" value="F:2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02516">
        <property type="entry name" value="CDP-ME_synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00108">
        <property type="entry name" value="IspD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001228">
        <property type="entry name" value="IspD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034683">
        <property type="entry name" value="IspD/TarI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018294">
        <property type="entry name" value="ISPD_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01128">
        <property type="entry name" value="IspD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00453">
        <property type="entry name" value="ispD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01295">
        <property type="entry name" value="ISPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="5 7 9" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 9" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="41"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="48"/>
        </location>
    </feature>
    <feature type="site" description="Positions MEP for the nucleophilic attack" evidence="7">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <feature type="site" description="Positions MEP for the nucleophilic attack" evidence="7">
        <location>
            <position position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH83071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="269" mass="27664" checksum="15C0E5DD4F99A100" modified="2015-07-22" version="1">MSPSGTSDSPAASVRTRPGHSDPSGPYRCAAVIPAAGRGVRLGPGAPKALRALGGTPMLVHAVRALSRARAVSLVVVVGPPGEAAQVRTLLDDHLEHLDSTEIVVVPGGDTRQDSVRLGLAALPDDVDVVLVHDAARPLVPVDTVEAVAAAVRAGAPAVVPALPVTDTVKQVVPGGEPGRPEPVVATPERAALRAVQTPQGFDRRVLTEAHEKVPAAGEGATDDAGMVERLGVEVVLVPGHEEAFKVTRPLDMVLAEAVLARRRATDAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N508</accession>
    <name>A0A0F7N508_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AA958_09740</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015807.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_09740"/>
    <dbReference type="EnsemblBacteria" id="AKH82464">
        <property type="protein sequence ID" value="AKH82464"/>
        <property type="gene ID" value="AA958_09740"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_09740"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2053"/>
    <dbReference type="OrthoDB" id="66120at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 9" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519787" evidence="7">
        <location>
            <begin position="48"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S8" evidence="8">
        <location>
            <begin position="207"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="144"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH82464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="1108" mass="115074" checksum="DA81D50A43CFC422" modified="2015-07-22" version="1">MTISPRRTPGRIPGGGRPRAAARIALAAGLAAVLTATGSAATQAAEGAPEPDRPKAAADKLGAKDAELLAEAKAAGAKNVTLLVAVEPGQAAEVADTFRAVRGASVGRTHDRLGYVRATVPTGRADAAIAGAAKLSAVQGIDLNEEIELPDPRPEADRAEGDKGGKGSGAQGAYPAPGRSTPAENPYQPAHETGAVDFVEKHPKADGRGVTIGILDSGVDLAHPALRKTTTGERKITDWVTATDPIIDGDRTWRPMVTDVSGPAFTFNDREYTAPRGDYSVNLFSENATLGGEMRGDLNRDGDTTDSWALLYDAAAGTVRVDLGDDGDFTNDKPMAPYGEDHEFRYFGADDPGTAIAEAIPFVVEIRKDVPMDPYGGDWIGKKEDFVNIGVVEGAHGTHVAGITAANGLFGGRMNGAAPGAKLVSSRACTWSGGCTAVALTEGMIDLVANRGVDVVNMSIGGLPPLNDGNNARAALYNRLIDTYGVQLVISAGNDGPGANTIGDPGLADKVISVGAAVSRETWAANYGSQVRTRYAMMPFSSRGPREDGGATPTITAPGASVNTIPTWQPGSPVAEAGYALPPGYGMLQGTSMSSPQTAGAAALLLSAAEREGIDVTPNALRTALTSTADHIPGVQTYAEGAGLVDVVDAWDSLEDGATAYEYKVEAPVDTVLDGFLATPGVGTGVYDRESGPARGGSETYEITLTRTSGPAGGTPHELEWQGNDGTFKLLGDDDVTLRRGQPVTVKVQAKPRSAGLHSAALLVDGKRTEGIDHRVLTTVVTSQELAAPAYGHQVSNEVQRNSTRSYFVKVPEGAKTLEVAMSGLRGKSQTRWIAIDPWGIPADETSTPFCYNNYDNPANTCRPDLRSYDNPMPGVWEIEVESRRTSPELDNPFTVEAAVLGAAFDPEVQTIDEAKVGTPSPVEWTVTNGFAPVAGKLAGGPLGSGLSTRPEIADGDTNTTTVEVGEGVTRFDAVIGATSDANADLDLTVYRDGEPVAQSADADSEEGVTLTDPEPGTYTVEVYAYDVPAGTTAYDYRDVYFSPALGEVGVADEPVELDSGASAEVGAEVTVAAPGPEGREFFGEVQLRNARGTVAGAGSVRIGTVVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5F7</accession>
    <name>A0A0F7N5F7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_14730</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016586.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH83271">
        <property type="protein sequence ID" value="AKH83271"/>
        <property type="gene ID" value="AA958_14730"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_14730"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3102"/>
    <dbReference type="OrthoDB" id="1857862at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014322">
        <property type="entry name" value="RNA_pol_sigma-B/F/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02980">
        <property type="entry name" value="SigBFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="5">
        <location>
            <begin position="48"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4" evidence="6">
        <location>
            <begin position="213"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH83271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="284" mass="31621" checksum="B57B86346EE9FEE8" modified="2015-07-22" version="1">MLDARTKSTRRTHPHDDAPDTAALFRRIAALPDGPEKTALRQDAVCAWMPMATRLAGRFRNRGESFADLEQVARLGLVRAVSRYDPMVGTAFASYAVPTIVGEVKRHFRDHMWAVHVPRRAKELRQQVHTANRELGDSPTSAGPAVAEIAAHTGLSEQEVRRGQGALDCFTAQSLDATLDPSEDDYPLAATLGRDDPGFGRAIDRAALRPLVQALPEQERRILYLRFFCDMTQRRIGDELGFSQMHISRLISATCARLRDQVLADAGAPHRVMDQRGRRPHGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N601</accession>
    <name>A0A0F7N601_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 2">Peptidyl-tRNA hydrolase</fullName>
            <shortName evidence="1">PTH</shortName>
            <ecNumber evidence="1 2">3.1.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pth</name>
        <name evidence="4" type="ORF">AA958_12015</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 2">
            <text>an N-acyl-L-alpha-aminoacyl-tRNA + H2O = a tRNA + an N-acyl-L-amino acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54448"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:13883"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59874"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:138191"/>
            <dbReference type="EC" id="3.1.1.29"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the PTH family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.29" evidence="1 2"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016173.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_12015"/>
    <dbReference type="EnsemblBacteria" id="AKH82838">
        <property type="protein sequence ID" value="AKH82838"/>
        <property type="gene ID" value="AA958_12015"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_12015"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2528"/>
    <dbReference type="OrthoDB" id="1676462at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:aminoacyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00462">
        <property type="entry name" value="PTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00083">
        <property type="entry name" value="Pept_tRNA_hydro_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001328">
        <property type="entry name" value="Pept_tRNA_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018171">
        <property type="entry name" value="Pept_tRNA_hydro_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036416">
        <property type="entry name" value="Pept_tRNA_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17224">
        <property type="entry name" value="PTHR17224"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01195">
        <property type="entry name" value="Pept_tRNA_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53178">
        <property type="entry name" value="SSF53178"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00447">
        <property type="entry name" value="pth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01195">
        <property type="entry name" value="PEPT_TRNA_HYDROL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01196">
        <property type="entry name" value="PEPT_TRNA_HYDROL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH82838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="196" mass="21210" checksum="9A3E07B48312421D" modified="2015-07-22" version="1">MSDAAQPWLVVGLGNPGPGYAGNRHNVGFMVADLLAERVGGRFKAHKARAQVVEARLGLPGPAGRRIVLAKPMTYMNLSGGPVSALAGFYKVPLERMVVVHDELDLDYGTLRLKLGGGDNGHNGLKSLSKSLGREYLRVRFGVGRPPGRMEVADYVLKDFSAAERKELDYFVDRTADAVEALVTEGLERAQNTYNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N659</accession>
    <name>A0A0F7N659_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_08880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015669.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_08880"/>
    <dbReference type="EnsemblBacteria" id="AKH82322">
        <property type="protein sequence ID" value="AKH82322"/>
        <property type="gene ID" value="AA958_08880"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_08880"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1870"/>
    <dbReference type="OrthoDB" id="1836962at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH82322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="135" mass="14724" checksum="954488D3C5477E14" modified="2015-07-22" version="1">MNPQEDGDKLTVTGRLVKILVHRREDRGMSVDEWASRCVRSGEVHELVTTDQHDTTTGARVDRVGFLGFVEISEAGVVDRGDPVVIDGKRVGSVLGFDSCHFPNHYNILIAVDATVTGRELGLTPDMKVSIGPQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N683</accession>
    <name>A0A0F7N683_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_12410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016238.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_12410"/>
    <dbReference type="EnsemblBacteria" id="AKH82903">
        <property type="protein sequence ID" value="AKH82903"/>
        <property type="gene ID" value="AA958_12410"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_12410"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2608"/>
    <dbReference type="OrthoDB" id="343485at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025337">
        <property type="entry name" value="Questin_oxidase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14027">
        <property type="entry name" value="Questin_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="371" mass="39257" checksum="0177F682243854A3" modified="2015-07-22" version="1">MEKSREDARTETGRTRDDSGVLDEALERLHAAGPERQGWLTNHGPMAVEALVYGDRAATVHRWLDRYRDKLEDMPPQARPIDPAAWHEALGDPARLGDWPAYFARELDARPWREVLAEWWPRLLPGLAGAATHTVIRAGHAVRTLQDTEAAGHAPTAPRVTELAHALGYWAARYARLPSAPVPAGTAGPDAALAAVPAVPAQAGGIRERLAQLTPESTPGWPAAVSALTPARTPEEAREALSSLVRAAVHRYAAYGHGEPVMLVHAATAPNAVLRTLPALPRDLWVPSYAAAWAASAAVTAAYGPAAPLPPDRIPAPPAGDAAAAADELLTRAAAHGDEHTIKFVDTALDVGDGTARVAALQSVALIDPAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N695</accession>
    <name>A0A0F7N695_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_12515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_12515"/>
    <dbReference type="EnsemblBacteria" id="AKH82918">
        <property type="protein sequence ID" value="AKH82918"/>
        <property type="gene ID" value="AA958_12515"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_12515"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2629"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519298" evidence="1">
        <location>
            <begin position="33"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="209" mass="20842" checksum="1BBF4F049E8B1E00" modified="2015-07-22" version="1">MRRLTRSAAVAATALMAAVGFTVSSASATAQATWTVSPGGPFTAHSGNTQLGVPNAVLTCTDSDANGTLKSGPGLDGAGIGDIANLTFTNCSVAGILFTVDTSSALPWKLNVTGVDPGNANRVRGSISGIVAKIADPDGICTATFAGPSGPTAPGTVTGYYDNGTDQLVIQDGNLTAHNANCLGIINNGDHAAFTGNYDVTPGQTITLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6F3</accession>
    <name>A0A0F7N6F3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AA958_17120</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_17120"/>
    <dbReference type="EnsemblBacteria" id="AKH83646">
        <property type="protein sequence ID" value="AKH83646"/>
        <property type="gene ID" value="AA958_17120"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_17120"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3600"/>
    <dbReference type="OrthoDB" id="1200451at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015689">
        <property type="term" value="P:molybdate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004606">
        <property type="entry name" value="Mop_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005116">
        <property type="entry name" value="Transp-assoc_OB_typ1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03459">
        <property type="entry name" value="TOBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51866">
        <property type="entry name" value="MOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 6" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="21"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="Mop" evidence="8">
        <location>
            <begin position="301"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="53"/>
            <end position="60"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH83646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="366" mass="38881" checksum="F3D8C65182EDEF93" modified="2015-07-22" version="1">MSDDSVREGGGVEADAEMPGESGLDARLVVERGAFQLDVALRARPGDVLALLGPNGAGKTTALRALAGLVPLTDGHLRLDAAELDRTPPEDRPVGVVFQDYLLFPHLSALDNVAFGPRCHGATKAGARAEAAAWLARMDLSEHAAAKPRRLSGGQAQRVALARALATRPRLLLLDEPLAALDARTRLEVRAQLRRHLADFEAVAVLVTHDPLDAMVLADHLVVIEDGRIVQQGAPTEIARRPRTDYIAHLVGLNLYRGRARGHTVDLAEGPAITTADDLTGPVFVAFPPSAVTLHRDRPTGSSARNVWRCAVAGLETHADQIRAELTGELPLAADLTTTAAADLDLHPGAEVWAAVKAIQTHAYPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6L7</accession>
    <name>A0A0F7N6L7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 3">Nucleoside diphosphate kinase</fullName>
            <shortName evidence="1">NDK</shortName>
            <shortName evidence="1">NDP kinase</shortName>
            <ecNumber evidence="1 3">2.7.4.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Nucleoside-2-P kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ndk</name>
        <name evidence="5" type="ORF">AA958_09615</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'-deoxyribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:44640"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a ribonucleoside 5'-diphosphate + ATP = a ribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:18113"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the NDK family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.6" evidence="1 3"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015786.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_09615"/>
    <dbReference type="EnsemblBacteria" id="AKH82442">
        <property type="protein sequence ID" value="AKH82442"/>
        <property type="gene ID" value="AA958_09615"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_09615"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2026"/>
    <dbReference type="OrthoDB" id="1752581at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006241">
        <property type="term" value="P:CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006165">
        <property type="term" value="P:nucleoside diphosphate phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006228">
        <property type="term" value="P:UTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.141">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00451">
        <property type="entry name" value="NDP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034907">
        <property type="entry name" value="NDK-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036850">
        <property type="entry name" value="NDK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001564">
        <property type="entry name" value="Nucleoside_diP_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023005">
        <property type="entry name" value="Nucleoside_diP_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00334">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01243">
        <property type="entry name" value="NUCDPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00562">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54919">
        <property type="entry name" value="SSF54919"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00469">
        <property type="entry name" value="NDP_KINASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 3 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NDK" evidence="4">
        <location>
            <begin position="2"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="active site" description="Pros-phosphohistidine intermediate" evidence="1">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH82442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="137" mass="14972" checksum="066EC6B1C363C77F" modified="2015-07-22" version="1">MSQRTLVLLKPDAVRRGLVGEIIGRIERKADWSIAALELRTLDRSILEQHYAEHVGRPFYEPLVEFMASGPVVALVVEGERVIEGVRALAGPTDPIAAAPGSIRGDFGTVVRENLVHASDSEESAARELKLFFPDLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6N1</accession>
    <name>A0A0F7N6N1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">30S ribosomal protein S17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rpsQ</name>
        <name evidence="6" type="ORF">AA958_21220</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the universal ribosomal protein uS17 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_21220"/>
    <dbReference type="EnsemblBacteria" id="AKH84295">
        <property type="protein sequence ID" value="AKH84295"/>
        <property type="gene ID" value="AA958_21220"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_21220"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4469"/>
    <dbReference type="OrthoDB" id="2035880at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="F:structural constituent of ribosome"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Ribosomal_S17_B"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Ribosomal_S17_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744">
        <property type="entry name" value="PTHR10744"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="uS17_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RIBOSOMAL_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 4 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 3 5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH84295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="95" mass="10921" checksum="2DCC5CBB6F86C2B9" modified="2015-07-22" version="1">MSETNVTEETKTERGFRKTREGLVVSDKMDKTVVVAVEDRVKHALYGKVIRRTTKYKAHDEQNSCGVGDRVLLMETRPLSATKRWRVVEVLEKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6N3</accession>
    <name>A0A0F7N6N3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_13070</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016337.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_13070"/>
    <dbReference type="EnsemblBacteria" id="AKH83004">
        <property type="protein sequence ID" value="AKH83004"/>
        <property type="gene ID" value="AA958_13070"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_13070"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2750"/>
    <dbReference type="OrthoDB" id="1499826at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="411"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH83004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="452" mass="47092" checksum="9D2A0F43CE5CDB4F" modified="2015-07-22" version="1">MTRPEDFPNLGFDPAPGDLDTVRRLVTAIGTVTGQSGTAQSQLKRIGETDGIWVGKAADAFSDSVSEIPPYLEKALTSLNAAHRALSAWETGLTGYQDRARRLEREAEDAAARVGSAQRALDGLPGDTEGMTDKEKEEHKKDKKGKTASLDTASAELEAIRGRARALHAEFNGDAETAARQIKNAADDAPPEPNWFERRLDDLGNLLEAAWDTITDPNFWKLIGDILADVAMVIGVICLLAMPFGGIAGLALIGLWVGAGAFAAHAIALAGGAEGMTWQTLAWDAAGVLAGGIGLAGARLAQSGRALVQAGRNLRATEGFAAALGRVGPGNWGNLARLPSGMANSLRGFAMSGQGWMNVATGNLVDWSATIAGAGFAIGSNMNPGRWTDGNWNMADIPVIGPISALTEYRPPEPDVVAPGPLPPRVDPPAMLASAGDSFTRGLSPAQMGTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6N9</accession>
    <name>A0A0F7N6N9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sugar ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_13420</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016394.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_13420"/>
    <dbReference type="EnsemblBacteria" id="AKH83063">
        <property type="protein sequence ID" value="AKH83063"/>
        <property type="gene ID" value="AA958_13420"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_13420"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2822"/>
    <dbReference type="OrthoDB" id="1200451at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03301">
        <property type="entry name" value="ABC_MalK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015855">
        <property type="entry name" value="ABC_transpr_MalK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040582">
        <property type="entry name" value="OB_MalK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17912">
        <property type="entry name" value="OB_MalK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
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    </dbReference>
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    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="4"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH83063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="378" mass="40492" checksum="E3C22B603A38AD51" modified="2015-07-22" version="1">MATVSFDKATRVYPGSEKPAVSELEISIADGEFLVLVGPSGCGKSTSLRMLAGLEDVNSGTIHIGDRDVTHLPPKDRDIAMVFQNYALYPHMTVADNMGFALKIAGVPKTEIRQKVEDAAKILDLTEYLGRKPKALSGGQRQRVAMGRAIVREPQVFLMDEPLSNLDAKLRVQTRTQIAGLQRRLGVTTVYVTHDQVEAMTMGDRVAVLKDGLLQQVATPREMYDKPENLFVAGFIGSPAMNLVEVPITDGGVKFGNSVVPVSREALAAASDKGDRTVTVGVRPEHFDIANGDTPADKTLSKEKDGAPAGLPVTVNVVEELGADAYVYGSANVGGEDKDLVVRVSGRAVPEKGSTLHIVPRSGETHVFSTSTGERLSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6V4</accession>
    <name>A0A0F7N6V4_9ACTN</name>
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            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
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        <name evidence="7" type="ORF">AA958_18180</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
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        <property type="protein sequence ID" value="AKH83816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017116.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_18180"/>
    <dbReference type="EnsemblBacteria" id="AKH83816">
        <property type="protein sequence ID" value="AKH83816"/>
        <property type="gene ID" value="AA958_18180"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_18180"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3822"/>
    <dbReference type="OrthoDB" id="1233189at2"/>
    <dbReference type="Proteomes" id="UP000034283">
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    </dbReference>
    <dbReference type="GO" id="GO:0016021">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="29"/>
            <end position="208"/>
        </location>
    </feature>
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        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH83816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="243" mass="25747" checksum="8F9A17A523493F40" modified="2015-07-22" version="1">MKASGCLAANEWICGEYVRSRSDELVDATVQHVWITLASVGIGLLVSFPLALIARRWRVLTGPVLGLTTVLYTIPSLAMFSLLVPIMGISASVVVTGLVLYSLTILIRNLLAGLDSVPAETREAARGMGYGQTRLLFAVELPLALPAVMAGLRMATVSTIAMTTVGGIIGYGGLGNLIVDGMRTLFKAQVLTASVLCVLLAVLADLLILGLQRLLTPWTRAQRRGGGGGRFRARTAGRQKETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6X2</accession>
    <name>A0A0F7N6X2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
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    </gene>
    <organism evidence="7 8">
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        <lineage>
            <taxon>Bacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015919.1">
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_10460"/>
    <dbReference type="EnsemblBacteria" id="AKH82577">
        <property type="protein sequence ID" value="AKH82577"/>
        <property type="gene ID" value="AA958_10460"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_10460"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2204"/>
    <dbReference type="OrthoDB" id="1688736at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="104"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
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            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="104"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH82577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="331" mass="37412" checksum="820C24640FAA18A4" modified="2015-07-22" version="1">MTQTGTAVDAPPSAEGGAAPKRPATEDRRQKWRSRRYRWDAKFSPYAFISPFFLFFAAFGLFPLLYTAWASLHRVELTAPTDMEWAGLHNYTRLFEDHFFWNSLWVTFTLAVLSTVPQLLMAMGLAHLLNYKMRGSSFFRVAMLAPYATSVAAATLVFAMLYGRDYGLINWFLGLFGVDEIDWKSGDWTSKIAISTIVIWRWTGYNTLIYLAAMQAVPHDLYESAALDGASRWKQFRYVTIPSLRPTILFTVVVSTIGSVQLFGEPLLFEEGAGASGGPDHQFQTLGLYLYEQGWRNLHLGRAAAIAWVMFLILVVIGIVFGLISRRLRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N721</accession>
    <name>A0A0F7N721_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HATPase_c domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_18435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_18435"/>
    <dbReference type="EnsemblBacteria" id="AKH83856">
        <property type="protein sequence ID" value="AKH83856"/>
        <property type="gene ID" value="AA958_18435"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_18435"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3869"/>
    <dbReference type="OrthoDB" id="1832160at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HATPase_c" evidence="1">
        <location>
            <begin position="6"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="132" mass="14265" checksum="E93C1BF826CD6779" modified="2015-07-22" version="1">MRSRTFPRSPDAVARARDFVAGCILGCAPEQAADIVLCVSELATNAVQHTPAGHRFLVRIIPNDGALRIEVHDASADTPYLRTTVDTDERGRGLRLVSEVADDWGVSARRGPGKIVWAEFKIWAAAAVEAPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N735</accession>
    <name>A0A0F7N735_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Proline-specific permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">proY</name>
        <name evidence="9" type="ORF">AA958_10740</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015963.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_10740"/>
    <dbReference type="EnsemblBacteria" id="AKH82622">
        <property type="protein sequence ID" value="AKH82622"/>
        <property type="gene ID" value="AA958_10740"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_10740"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2259"/>
    <dbReference type="OrthoDB" id="430372at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amoino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="251"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="289"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="342"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="369"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="410"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="439"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="AA_permease" evidence="8">
        <location>
            <begin position="28"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH82622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="476" mass="50589" checksum="6170CF82D3BD234E" modified="2015-07-22" version="1">MTTAKVPEGGAAPSSEEGYERGLGSRQIQMIAIGGAIGVGLFLGAGKIIEKAGPSLIFLYALAGVVIFFIMRALGELLLYRPVSGSFAEYAREFLGPYFGYVTGWTYWLMWAVTGMTELTAAAIYINYWWPAIPQWVSALGFLLLLFGVNLISVKIFGELEFWFSMVKVTAIIGMIVIGVGVLTLGFSAAGNTATTTNLWNHGGFFPNGIGDSLMTLQGVMFAYLAVELVGVTAGESANPEKTLPKAINTLPWRIVIFYVGSLIVILSVVRWTEFSEGISPFVAAFGKIGIPLAAGIVNFVVLTAALSSCNSGMYSTGRMLRALAANAEAPKVFGRLSPRRVPAAGIAMSVVVMSVGVVLNYLVPEKAFGYVMSVATAAGIWTWAMILVSHIRYRRRVAAGLLPASSFPAPGGVVCSWLALVFLAFVTVLTALDADARVSLYVGAGWAVLLSGGWAVSRRRAAVREAAPEYVAGAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7C5</accession>
    <name>A0A0F7N7C5_9ACTN</name>
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        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AA958_11460</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_11460"/>
    <dbReference type="EnsemblBacteria" id="AKH82747">
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        <property type="gene ID" value="AA958_11460"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="760677at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
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    </dbReference>
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        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
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            <end position="124"/>
        </location>
    </feature>
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        <location>
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            <end position="223"/>
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            <end position="384"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
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    </evidence>
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            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH82747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="385" mass="41423" checksum="43E196CBBF965F8C" modified="2015-07-22" version="1">MAGAPEFDLYRPAEEHDMLRDAVRSLAEAKIEPFAAEVDEEARFPQEALDALVTNDLHAVHVPEAYGGAGADALATVIVIEEIARVCASSSLIPAVNKLGSLPLMLSASEELKAKYLTPLARGEAMFSYCLSEPEAGSDAAGMKTRAVRDGDSYVLNGVKRWITNAGISEYYTVMAVTDPEKRSKGISAFVVEKSDEGVSFGAPEKKLGIKGSPTREVYLDNVCIPADRMIGAEGTGFATAMKTLDHTRITIAAQALGIAQGALDYAKGYVRERKQFGKPVADFQGVQFMLADMAMKIEAARQLTYAAAATSERGGADLTFQGAAAKCFASDTAMEVTTDAVQLLGGYGYTRDYPVERMMRDAKITQIYEGTNQVQRIVMARNLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7K8</accession>
    <name>A0A0F7N7K8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_15235</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_15235"/>
    <dbReference type="EnsemblBacteria" id="AKH83344">
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        <property type="gene ID" value="AA958_15235"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="DUF488"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04343">
        <property type="entry name" value="DUF488"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH83344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="122" mass="14276" checksum="C9EA4F47DE8B5A35" modified="2015-07-22" version="1">MATKHAPPRIRRVYDDPAGDDGTRVLVDRIWPRGMTKEKAHVDEWLKAIAPSDELRHWLHADFERYPDFVKRYRKELADHERAEALAHLRALYEQGPLTLVTSTKEVRRSHLTVLAEELERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7U5</accession>
    <name>A0A0F7N7U5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_20075</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017391.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_20075"/>
    <dbReference type="EnsemblBacteria" id="AKH84101">
        <property type="protein sequence ID" value="AKH84101"/>
        <property type="gene ID" value="AA958_20075"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_20075"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4229"/>
    <dbReference type="OrthoDB" id="1626415at2"/>
    <dbReference type="Proteomes" id="UP000034283">
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    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026898">
        <property type="entry name" value="PrsW"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36844">
        <property type="entry name" value="PTHR36844"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13367">
        <property type="entry name" value="PrsW-protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="145"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="221"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="260"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="416"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH84101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="442" mass="47986" checksum="0348EB35A1AEF96E" modified="2015-07-22" version="1">MTRPREPEEFGPRPEYEDARPKAAETTAHTPPAGRRFWRRRGVRIGAVGTVLTLAGLAILWLVWTETGTHGMLLGSGLALLPVPLLIAGFLWLDRVAPGPWRYRVFAFAWGAFAATLVAMLANTFAARWIATGLPTASSREADLWGMAVVAPVVEESAKAAAILLIFLFRRHYFSGLVDGLVLAGIIGTGFAFTENILYLGRAYEENQTFGDSGPLATVTVTFIARIVFSPFAHPLFTAMAGIGFGLAAMTVAGQRVRRVLLPVAGLLLAIAMHALWNGSAVMNGYAFLGAYAFVMAPVFGLLVWLAVWSRGGKLRTIRTQLPAYAQAGWLVPAEPVALSSLRIRKIARSLARHAHGEEARRAVADYERAATTLALLRAQATQGRPAKDYATREQALLTAMWQNKALAQPALTRAAYTTNPPRPHPWPPRQGTAHPPHPPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7V2</accession>
    <name>A0A0F7N7V2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cell division protein CrgA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">crgA</name>
        <name evidence="4" type="ORF">AA958_16315</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in cell division.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CrgA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_16315"/>
    <dbReference type="EnsemblBacteria" id="AKH83513">
        <property type="protein sequence ID" value="AKH83513"/>
        <property type="gene ID" value="AA958_16315"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_16315"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3437"/>
    <dbReference type="OrthoDB" id="2085550at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00631">
        <property type="entry name" value="CrgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009619">
        <property type="entry name" value="CrgA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06781">
        <property type="entry name" value="CrgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH83513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="85" mass="9344" checksum="025BC8093D2D90CB" modified="2015-07-22" version="1">MPKSRIRKKADYTPPPAKSGEFKLSGTGRSWVAPLMLALFVIGLAWIVVFYVTTGDLPLESIGNWNIVVGFGFILAGFVVSTQWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7V9</accession>
    <name>A0A0F7N7V9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_16040</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016781.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_16040"/>
    <dbReference type="EnsemblBacteria" id="AKH83469">
        <property type="protein sequence ID" value="AKH83469"/>
        <property type="gene ID" value="AA958_16040"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_16040"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3379"/>
    <dbReference type="OrthoDB" id="1833499at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH83469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="303" mass="33447" checksum="7DAF62CDBB13418F" modified="2015-07-22" version="1">MTTIRIDSVSRWFGNVVAVNDVSMAIGPGVTGLLGPNGAGKSTLINMMAGFLPPSTGAVTLDGVRIWRNERVYKQIGLVPEREAMYDFLTGREFVLANAELHGLGAEAARKALATVEMEYAQNRRISTYSKGMRQRVKMASALVHEPDVLLLDEPFNGMDPRQRMHLMDLLRQMGAAGRTVLFSSHILEEVEQLAAHIEVIVAGRHAASGDFRKIRRLMTDRPHHYAVRSSDDRALASALIADPSTAGLELDRRDGVLHIQAVDFARFTELLPRVARDHGIRLYEVSPSDESLESVFSYLVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N806</accession>
    <name>A0A0F7N806_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphate transport system permease protein PstA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AA958_16645</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016873.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_16645"/>
    <dbReference type="EnsemblBacteria" id="AKH83568">
        <property type="protein sequence ID" value="AKH83568"/>
        <property type="gene ID" value="AA958_16645"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_16645"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3503"/>
    <dbReference type="OrthoDB" id="1763210at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005672">
        <property type="entry name" value="Phosphate_PstA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00974">
        <property type="entry name" value="3a0107s02c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="176"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="324"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="8">
        <location>
            <begin position="138"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH83568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="355" mass="37409" checksum="C9D9C032D821118A" modified="2015-07-22" version="1">MSAQTIADKRPVDRLGIQQPRLPRFAPLGIAGGAAAVAVAIGVLADLGSRIQWGLIAAILFVIGQFVISTAVEGGRQAKDRLATSLVWVAFLLAVVPLASLIWETVSKGIKVTDGYFLTHSMSGVVNVAPGGGVYHALMGTIEQVLIATLIATPIGLLTAVYLVEYGRGALAKAVTFFVDVMTGIPSIVAGLFVLSLWIMILDFGYSGFAGALALAILMMPVVVRSTEEMLKLVPNELREASYALGVPKWKTILKVVLPTSLGGITTGVMLAVARITGETAPVLLLVFGSPAINNNPFDGGQASLPLYIYQQWGAGTSASFDRAWAAALVLIVFVMILNLLARGIARWKAPKTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N823</accession>
    <name>A0A0F7N823_9ACTN</name>
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        <name evidence="5" type="ORF">AA958_12740</name>
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    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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    <dbReference type="EnsemblBacteria" id="AKH82947">
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    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH82947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="454" mass="50012" checksum="AAC612337F4498D8" modified="2015-07-22" version="1">MPTAASGSRTDLVEGLMARFPHVPREAVIKEDLLRGGMAFDDSALSGAGEDGSGEVKPKSYFIFSFDHGTLPELGAAALNRPPEEVVLTGGPYDLRRTVVSVRVNPSSPYRVKPGDDGALGLYLDGVRIADVGLPPMPDYYRHKLANGKSVMEVAPTIQWGYLIYLTVFRVCQYFGAKEECQYCDINHNWRQHKAAGRPYTGVKPVEEVLEALEIIDRYDTAKTSTAYTLTGGAVTSHIGGKDEADFYGQYAKAIEERFPGRWIGKVVAQALPKADVQRFRDYGAQIYHPNFEVWDRRLFELYCPGKERYVGRDEWHRRILDSAEVFGPSNVIPNFVAGVEMAEPFGFTTVDEAIASTREGLDFFMSHGVVPRFTTWCPEPTTPLGKANPEGAPLEYHIRLLETYQDALDTHGLSSPPGYGPPGAGRAVFSVSSFMDSMPLPDDASEAAVPART</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N881</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="2" type="ORF">AA958_17230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AKH83663">
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    </dbReference>
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    <dbReference type="PATRIC" id="fig|444103.5.peg.3623"/>
    <dbReference type="OrthoDB" id="1755401at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519350" evidence="1">
        <location>
            <begin position="28"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="153" mass="14720" checksum="960ADD223FD18FB3" modified="2015-07-22" version="1">MKNARTALGVGAAVAGALLLAAPSALAVEPQTATIGFDCGSWGAGEATLEATQDGTAATITITTDAITAPIPIGAGSASSTLTLTRNGTDTVEFSGSSNPAIPAGAPADTGPLDGTVASGDSLEATSLTVSVLGITATCDATTPQNPGPFVFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8E0</accession>
    <name>A0A0F7N8E0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AA958_13135</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016349.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_13135"/>
    <dbReference type="EnsemblBacteria" id="AKH83017">
        <property type="protein sequence ID" value="AKH83017"/>
        <property type="gene ID" value="AA958_13135"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_13135"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2764"/>
    <dbReference type="OrthoDB" id="760677at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="9"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="123"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="232"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH83017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="388" mass="41089" checksum="6A6E8943368F1906" modified="2015-07-22" version="1">MTSAILEPQEHRDLRAAVAALGTRYGRDYFTAAVRDGRHTDELWAEAGKAGYLGVNLPEAYGGGGGGIAELAIVLEELGAAGCPLLMLVVSPAICGTVIARFGTEEQKRQWLPGLADGTRKMAFGITEPDAGSNSHRITTTARRDGDDWVLSGRKVFISGVDIADATLIVGRTEDARTGKLKPCLFIVPRDAEGFRRSPIPMELHAPEKQFELVLDDVRLPADALVGDEDAGLLQLFAGLNPERIMTAAFALGLGRQAVARAVEYARTRQVWKGGAIGVHQAIAHPLAQAHIELELAGLMTQKAAALYDAGDDAGAGEAANMAKYAAAEAAAKAVDQAVHTLGGNGLSTEYGLAQMLTASRVARIAPVSREMILNYVSHQTLGLPKSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8M8</accession>
    <name>A0A0F7N8M8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DAO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_24710</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018127.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_24710"/>
    <dbReference type="EnsemblBacteria" id="AKH84875">
        <property type="protein sequence ID" value="AKH84875"/>
        <property type="gene ID" value="AA958_24710"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_24710"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5211"/>
    <dbReference type="OrthoDB" id="912110at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="domain" description="DAO" evidence="2">
        <location>
            <begin position="5"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH84875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="378" mass="37845" checksum="E2DE0CFD684C8936" modified="2015-07-22" version="1">MTVADVLVIGGGIAGAAAGWFLARQRGGSRVTLLEAERAPGMHATGRSAALFSEYFGNATVRALTGHSRAFYAAPPAGFAAGALLTPRGVLALGTPETAAAFEAAKAAGAGAPRPAVELTAAAALALCPLLRPGAFDRALHKPGACDIDVGAAHQGFLRGLRAAGGTVVTGARVTGLCRRGGRWHAATSAGGFSAPLVVNAAGAWADDVAHLAGVAPAGLVAYRRTAALAPVPDGHDVTGWPMVTDVADTFYARPEPGGLLLSPADATPMVPGRARHDDTDVALAIARFEAMVALPLRHVTHAWAGLRTAAPDDTPVIGPDPDAPGFCWLAGLGGYGIQTAPAAGALLAALAAGDAPPTALRSLATDVTPVHTRTAPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8Q4</accession>
    <name>A0A0F7N8Q4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_18575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017175.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_18575"/>
    <dbReference type="EnsemblBacteria" id="AKH83878">
        <property type="protein sequence ID" value="AKH83878"/>
        <property type="gene ID" value="AA958_18575"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_18575"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3898"/>
    <dbReference type="OrthoDB" id="1585405at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015128">
        <property type="term" value="F:gluconate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003474">
        <property type="entry name" value="Glcn_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30354">
        <property type="entry name" value="PTHR30354"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02447">
        <property type="entry name" value="GntP_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002746">
        <property type="entry name" value="Gluconate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00791">
        <property type="entry name" value="gntP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="285"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="323"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="355"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="443"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="468" mass="48195" checksum="1598CED2D9716880" modified="2015-07-22" version="1">MTTVHLAQEVEDWTQTMSAGPLLAIAGAAVAVLLFLVIYLRVHAFLALVTISILTAFAAGIPAAQVIPVATAGFGTTLGSVALLVGLGAMLGRLVEVSGGAQSLADAMIRKFGEDRAPFALGVASLIFGFPIFFDAGLVVMLPIVFTIARRLGGGVLRYGLPAAGAFSIMHVFVPPHPGPVAATELLGADVGLVVAIGVVMAIPIWYVTSYLYGLWIGEKIVLQVPDILTGGPQEEKDTDPPSAATVIGLLLLPLVLIFANTGLDTARAAGWVEDTESWYNVARALGSTPVALLLTVFVASYVLGTRRGKGLEMIEKLVDSALGPVCAIILITGAGGMFGGVLRASGIGDALADAMSDLGLPVIIVAYVVATALRIAQGSATVALTTAAGLIQPVVLDADYNAVQLAAIVLATAAGSVTASHVNDSGFWLVGRFFNMDVKTTLKTWTVMETTIGLSAFGLASLLFVIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N904</accession>
    <name>A0A0F7N904_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH luxR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_25530</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018271.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_25530"/>
    <dbReference type="EnsemblBacteria" id="AKH85020">
        <property type="protein sequence ID" value="AKH85020"/>
        <property type="gene ID" value="AA958_25530"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_25530"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5382"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="954"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH85020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="1024" mass="108326" checksum="22F8DE3F6B552BA3" modified="2015-07-22" version="1">MLGRVESPEPSEPAGADAGTRTGARVFVGRAAELGALTEAYERAAAGEPCAVLVGGEAGVGKSRLVEEFLARAEAAGAVTAVGNCIESGADGLPFAPFSTALRALRRRLGDRLDEAVAGQEGELARLLPELGPIPDVPAAAQGEAGRARLYELAARMLEKLAGERVLVLVVEDLHWADHSTRELLGYLLRSVQAARLLVVATYRSDDLHRRHPLRPGLAELDRLRGVRRFELARFSRDEVRSQLAWLRGGEPPEDLVAEVYGRSDGNAFFVEELAAGLGAGTGGRGGPVAGRPAGGIGESLRDLLLVRAEALPDPARRIVALAAVGGDRVDTALLAAVSGLGEDALFDALRTAIGAGVLLPADERVDAYRFRHALMREAVSDDLLPGERARLSRRFAEALEADPALVRADERPARLAGYWYLAGDPARALPAVLAAAADARARHAFADQLALLERAVALWDEAPPASRTVPDSGGAYPRAEEPEFADLLAETVFAARLASAYGRAITLGDRALRLLGTRAPLRAAWFRVERARCVQGLGRGDGWADLDRAQELVRGLPPSPVHAQVLAEVANWQAMHTPGGGAIEAAERAVQLARLVGAEETELTVRIPRAWMMVDSGDVEGGIAEFHAVRERAVADGLVVAAARAYANLPSALEGVGRSAESLAAAEEAIAMLADSGLATYLSLSHGNRANALLSLGRWDEAEEAVDAQFRTARSTQLRGSALLDRALLALLRGDYAVVRGELAAAREEFGNDRQPQYELPRAGMTIRLAAAEGRVADVRAAFGQAVGDGLRLGMQRYAWPLLYATAGAEARLRGLPAAETGRPAALAAIRAAMRNLPRFAPPWEALALMTEAELCAAEGRDATARWAEAEAAWAELEWPYEQAVTRYRWAESALAGGQAAAAARDGAARVLRLAYDTARDLGAAGLVRDAEALAARARIALTAAAAPAEPEDPAESLGLTAREADVLRLVAAGRSNRQIAEELFISPKTASVHVSHILAKLGVAARGEAAAVAHRLRLFEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N956</accession>
    <name>A0A0F7N956_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_19230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017259.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_19230"/>
    <dbReference type="EnsemblBacteria" id="AKH83964">
        <property type="protein sequence ID" value="AKH83964"/>
        <property type="gene ID" value="AA958_19230"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_19230"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4043"/>
    <dbReference type="OrthoDB" id="1091968at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="300" mass="32277" checksum="F462EF37F2B5FFFF" modified="2015-07-22" version="1">MSTDAREWVWESSTSRGTARLVLLSIADRVADEQCVSWASLTSLAARTNASVSTVREAIGRLVEAGELEQLDDLVGPQRSTVYRLPLAALAIAQAQQQHQEEHSGEEVPIEEPGALPAVRLSALGRYRIRPRKVPETGIARCRKPAVPETGTSRSKPAPRRAGDRHSEVPETGTQNSSEPEKNGSKSSSAGGAVTSAAGWRPDPATLAWIREQGHLDRLGEQALKAADAKWRAHRADFAPRPAGAWAADWRSWIAREHSPHRRGLYAVPGSSPARPGGMTRAQAHTAALLAALDEPTGTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N974</accession>
    <name>A0A0F7N974_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_19890</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017358.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_19890"/>
    <dbReference type="EnsemblBacteria" id="AKH84068">
        <property type="protein sequence ID" value="AKH84068"/>
        <property type="gene ID" value="AA958_19890"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_19890"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4191"/>
    <dbReference type="OrthoDB" id="551294at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="9"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="264"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH84068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="525" mass="56787" checksum="B37E520E6BFFBC2D" modified="2015-07-22" version="1">MSSDAKPLLAMRGIAKSFPGVRALRGVELTVHAGEVVALLGENGAGKSTLMNVLAGVHPDYEGVIERDGVPAAIHSPRDAQRHGIGMIHQELNLVPELSVAENVFLGRELRTARGTVDKKAQEARARELLAGLGLAVPPRRPVKHCRLAEQQLIEVAKALNLDVRLLVMDEPTSALADAEVRRLFTVIRDLTARGVGVVYISHRLEELEEIADTVTVLRDGAYVGSRRMAETTRAELVRLMVGRPLGELFPRRAEQHRSGEVRLAAEGLTYVAQDGGPSLYDVDLSVRAGEIVGLAGLMGAGRSEVVQALFGHYGTRAHGRITVDGRPYRPRSPGHALRRGLALVAEDRKGQSLVTANTVRFNGSLAALARYRTPWRTVHRRRERAAVAGQIEALKVKTPGMETAVQHLSGGNQQKVVLAKCLLTRPSVLLMDEPTRGIDVGAKAEIHRLMDELAAQGTAILAVSSELPELIGMCDRVLVLCEGRLTGEFHRDPAHGPQAGQEAILTAAMARETVTTHHLRGTRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N989</accession>
    <name>A0A0F7N989_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Iron-dicitrate transporter ATP-binding subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">fecE</name>
        <name evidence="5" type="ORF">AA958_14980</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016622.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_14980"/>
    <dbReference type="EnsemblBacteria" id="AKH83307">
        <property type="protein sequence ID" value="AKH83307"/>
        <property type="gene ID" value="AA958_14980"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_14980"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3157"/>
    <dbReference type="OrthoDB" id="1048863at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="18"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="50"/>
            <end position="57"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH83307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="286" mass="30890" checksum="2AE024EF9FA84013" modified="2015-07-22" version="1">MRAGESTPTAAGARGHALSAADVTVAYDGVDVVHDASLRLRPGEVTVLVGPNGSGKSTLLRTLARLQRARRASLVIDEETDGFAMSTRHFARHVALLTQGRPTPSGLTVRDVVEFGRYPYRGRWGASDPGGRAAVDRALAMTGVTELAERGAEHLSGGQLQRVWLAGCLAQDTGVLLLDEPTNHLDLRYQVELLDLIRDLADDHRIAVGAVLHDLDQAAAVADRMVLLDDGRIVGDGRPEDVLLPELLSRAYGIRIDVDDDPLTGRLRTRAIGRHHKRSERLSTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9E3</accession>
    <name>A0A0F7N9E3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">tRNA pseudouridine synthase B</fullName>
            <ecNumber evidence="5">5.4.99.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">tRNA pseudouridine(55) synthase</fullName>
            <shortName evidence="5">Psi55 synthase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">tRNA pseudouridylate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">tRNA-uridine isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">truB</name>
        <name evidence="9" type="ORF">AA958_26320</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>uridine(55) in tRNA = pseudouridine(55) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:42532"/>
            <dbReference type="Rhea" id="RHEA-COMP:10101"/>
            <dbReference type="Rhea" id="RHEA-COMP:10102"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="EC" id="5.4.99.25"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.25" evidence="5"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018401.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_26320"/>
    <dbReference type="EnsemblBacteria" id="AKH85160">
        <property type="protein sequence ID" value="AKH85160"/>
        <property type="gene ID" value="AA958_26320"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_26320"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5541"/>
    <dbReference type="OrthoDB" id="1166299at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106029">
        <property type="term" value="F:tRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02573">
        <property type="entry name" value="PseudoU_synth_EcTruB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01080">
        <property type="entry name" value="TruB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002501">
        <property type="entry name" value="PsdUridine_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015225">
        <property type="entry name" value="tRNA_psdUridine_synth_fam2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014780">
        <property type="entry name" value="tRNA_psdUridine_synth_TruB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032819">
        <property type="entry name" value="TruB_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13767">
        <property type="entry name" value="PTHR13767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09142">
        <property type="entry name" value="TruB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16198">
        <property type="entry name" value="TruB_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01509">
        <property type="entry name" value="TruB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00431">
        <property type="entry name" value="TruB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TruB_N" evidence="6">
        <location>
            <begin position="30"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="TruB_C_2" evidence="8">
        <location>
            <begin position="188"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="TruB_C" evidence="7">
        <location>
            <begin position="243"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH85160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="300" mass="31085" checksum="9B78DFC7E096424C" modified="2015-07-22" version="1">MRGKPTGPDGLVIVDKPAGLTSHDVVGRLRRLARTRRVGHAGTLDPMATGVLVVGVEKATRLLGHLALTDKEYRATIRLGQTTVTDDAEGDVTAAADAGDLPPGAVDAGIAGLTGDIMQVPSAVSAIKVDGKRSYKRVLDGEAVELPARPVTVSTFVLHDVRAATAADGTRVTDLDVTVACSSGTYIRALARDLGAGLGVGGHLTALRRTRVGPYGLDGARTLEQLEERLDVLPIGDAAAAAFPRWDVDAEQARLLSHGVRVAVPEGLAEEPHAVFGPDGRFLALVEPAGGRAKALAVFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9K2</accession>
    <name>A0A0F7N9K2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8 13">Glutamyl-tRNA reductase</fullName>
            <shortName evidence="8">GluTR</shortName>
            <ecNumber evidence="4 8 13">1.2.1.70</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">hemA</name>
        <name evidence="18" type="ORF">AA958_20195</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 13">
            <text>(S)-4-amino-5-oxopentanoate + NADP(+) + tRNA(Glu) = H(+) + L-glutamyl-tRNA(Glu) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:12344"/>
            <dbReference type="Rhea" id="RHEA-COMP:9663"/>
            <dbReference type="Rhea" id="RHEA-COMP:9680"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57501"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="EC" id="1.2.1.70"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8 13">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from L-glutamyl-tRNA(Glu): step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="domain">
        <text evidence="8">Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="8">During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8 13">Belongs to the glutamyl-tRNA reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.70" evidence="4 8 13"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017408.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_20195"/>
    <dbReference type="EnsemblBacteria" id="AKH84119">
        <property type="protein sequence ID" value="AKH84119"/>
        <property type="gene ID" value="AA958_20195"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_20195"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4253"/>
    <dbReference type="OrthoDB" id="1358620at2"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00316"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008883">
        <property type="term" value="F:glutamyl-tRNA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00087">
        <property type="entry name" value="Glu_tRNA_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000343">
        <property type="entry name" value="4pyrrol_synth_GluRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015896">
        <property type="entry name" value="4pyrrol_synth_GluRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015895">
        <property type="entry name" value="4pyrrol_synth_GluRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018214">
        <property type="entry name" value="GluRdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036453">
        <property type="entry name" value="GluRdtase_dimer_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036343">
        <property type="entry name" value="GluRdtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006151">
        <property type="entry name" value="Shikm_DH/Glu-tRNA_Rdtase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00745">
        <property type="entry name" value="GlutR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05201">
        <property type="entry name" value="GlutR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01488">
        <property type="entry name" value="Shikimate_DH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000445">
        <property type="entry name" value="4pyrrol_synth_GluRdtase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69075">
        <property type="entry name" value="SSF69075"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69742">
        <property type="entry name" value="SSF69742"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01035">
        <property type="entry name" value="hemA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00747">
        <property type="entry name" value="GLUTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 11" id="KW-0521">NADP</keyword>
    <keyword evidence="6 8 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7 8 13" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GlutR_N" evidence="17">
        <location>
            <begin position="6"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Shikimate_DH" evidence="16">
        <location>
            <begin position="183"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Shikimate_DH" evidence="16">
        <location>
            <begin position="270"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="GlutR_dimer" evidence="15">
        <location>
            <begin position="362"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8 10">
        <location>
            <begin position="49"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8 10">
        <location>
            <begin position="114"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="240"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="469"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8 9">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 11">
        <location>
            <begin position="192"/>
            <end position="197"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for activity" evidence="8 12">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000445-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000445-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000445-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000445-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF05201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="AKH84119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="488" mass="50146" checksum="4DA472CB74AD37FA" modified="2015-07-22" version="1">MSVLVVGLSHRSAPVSVLERASLAPDARAKLLADAVAAAPVTEAAVLATCNRIELYAAVDKFHAGVAELSTLLAQHAGASLEELTPHLYVHYEDRAVHHLFTVGCGLDSMVVGEGQILGQIKESLALGQRLHTAGRTLNDLFQQALRVGKRAHSETGIDKAGQSLVSFGLAQLAAGAPVAEWVAGRRALVIGAGSMSSLAATVLARAGAAELVIANRTYERAERLAASLNAGSAVAGGWSTGPTAADTGAPAAGSIPSQTGPAEGTGGPAARAVRVEEIADELVTADVVVSCTGATGLVLTADEVRGALRRRDGDTPLALLDLAMPRDIDHALHETPGVRFVDIEALAGASADAPMAADVDQVRAIVAGEVDDFGAAQRAASITPTVVALRTMAQDVVAGEIARLEGRLPGLDERQRAEVAQTVRRVVDKLLHAPTVRVKELAATPGGAGYADALRELFDLDPATVDAVSRADSGRAAASARSEREPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9S0</accession>
    <name>A0A0F7N9S0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_24195</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018053.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_24195"/>
    <dbReference type="EnsemblBacteria" id="AKH84801">
        <property type="protein sequence ID" value="AKH84801"/>
        <property type="gene ID" value="AA958_24195"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_24195"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5098"/>
    <dbReference type="OrthoDB" id="1687028at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519344" evidence="3">
        <location>
            <begin position="36"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="63"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="106"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="4">
        <location>
            <begin position="304"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="372"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="398"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH84801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="428" mass="44697" checksum="44076E605C54AFEE" modified="2015-07-22" version="1">MFPTWSRFTDRHPRLVEAALLLLVAAVTSRQHAGAAHGWAAGQPLVAAALVPLLWRRRHPGPVVVVTAVCGAASAGLGYPLSLPLLAPSVLALYELAVRAPQRTVYTHYAVVLAMVVPVALLAENEDQDWAEESVGPVFWLLLPVLAGIAVQARRAYLDAVHLRAEHAERTREEEARRRVAEERVRIARELHDVVAHHMALAHAQAGTAARLARSRPDQAGEILGELTGTTSAALRELQATVGLLRQPGDPEGPAGPGPPGGSGEPLEPAPGLDRLPELAAAFASAGLPVSVAAEGAERPLPPGLDLTAYRIVQEALTNVAKHAGAGAARVRLAYAQDLLTVSVSDDGGAGRPPPRPGGGFGLIGMRERARAAGGSLRAGPRPDGGFTVTAELPLPVRQETPVPPAPGQAPVPQAPVPQTDEPSGEPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9V2</accession>
    <name>A0A0F7N9V2_9ACTN</name>
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        <submittedName>
            <fullName evidence="6">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_16030</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016779.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_16030"/>
    <dbReference type="EnsemblBacteria" id="AKH83467">
        <property type="protein sequence ID" value="AKH83467"/>
        <property type="gene ID" value="AA958_16030"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_16030"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3377"/>
    <dbReference type="OrthoDB" id="1833499at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="4"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="309"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="309"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH83467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="344" mass="36228" checksum="A26EF4D434BC20DF" modified="2015-07-22" version="1">MTVIATENLSKRFPRVTALDGLTLDIGPGVTGLVGANGAGKSTLIKILLGLSPASEGSATVLGLDVAAGSDTAATIRERVGYMPEHDCLPPDVSATEFVVHMARMSGLPATAARERTADTLRHVGLYEERYRPIGGYSTGMKQRVKLAQALVHDPQLVFLDEPTNGLDPVGRDDMLGLIRRVHADFGISVLVTSHLLGELERTCDHVVVIDGGRLLRSSSTSDFTQTTATLAVEVTDTDAHPDGTATLRKALAGAGLGITADGRLLYVEAEDDGTYDVVRDAVAGLGLGLVRMEQRRHRIAEIFRDDDTLPASTSTSTSTSENASADTNPSTPATDPAGSPHAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NA31</accession>
    <name>A0A0F7NA31_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phosphate ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">pstB</name>
        <name evidence="5" type="ORF">AA958_16640</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016872.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_16640"/>
    <dbReference type="EnsemblBacteria" id="AKH83567">
        <property type="protein sequence ID" value="AKH83567"/>
        <property type="gene ID" value="AA958_16640"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_16640"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3502"/>
    <dbReference type="OrthoDB" id="1416748at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015415">
        <property type="term" value="F:ATPase-coupled phosphate ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03260">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005670">
        <property type="entry name" value="Phosp_transpt1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43423">
        <property type="entry name" value="PTHR43423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00972">
        <property type="entry name" value="3a0107s01c2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH83567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="258" mass="28199" checksum="B6FFBE16CE62D5C5" modified="2015-07-22" version="1">MAKRIDISGLTAYYGDFKAIEDISMAVEPKSVTAFIGPSGCGKSTFLRTINRMHEVIPGARVEGKVMLDDENLYGSGVDPVSVRRVVGMVFQRPNPFPTMSVYENVAAGLKLNARYKKSELDDVVEKSLRGANLWNEVKDRLSRPGSGLSGGQQQRLCIARAIAVEPQVLLMDEPCSALDPISTLAIEDLIGDLKTRFTIVIVTHNMQQAARVSDRTAFFNLAAVGEPGRLIEIDDTDKIFSNPSVQATEDYVSGRFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NA35</accession>
    <name>A0A0F7NA35_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP synthase I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_24840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018148.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_24840"/>
    <dbReference type="EnsemblBacteria" id="AKH84896">
        <property type="protein sequence ID" value="AKH84896"/>
        <property type="gene ID" value="AA958_24840"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_24840"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5237"/>
    <dbReference type="OrthoDB" id="1956005at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="149" mass="15557" checksum="2A4A3D9CFA00E342" modified="2015-07-22" version="1">MQVNDARILRGAAIPTALAGVVAVVISSLAAGVKGGVGAAAATVVVLAFFCLGLFALQHFSRKNPELFLGIALITYTSQVLLLAVVMGLFKDTTLFNTKAFGFTVLAAALVFTAAMGRTHFRLKLPYVEPERETGAGEQRSGTATEAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAF1</accession>
    <name>A0A0F7NAF1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NADH dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_17410</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I 51 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016996.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_17410"/>
    <dbReference type="EnsemblBacteria" id="AKH83692">
        <property type="protein sequence ID" value="AKH83692"/>
        <property type="gene ID" value="AA958_17410"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_17410"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3662"/>
    <dbReference type="OrthoDB" id="688908at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03064">
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        <property type="entry name" value="Nuop51_4Fe4S-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
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    <dbReference type="Pfam" id="PF01512">
        <property type="entry name" value="Complex1_51K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10589">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="SSF142019"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="COMPLEX1_51K_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH_4Fe-4S" evidence="6">
        <location>
            <begin position="480"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH83692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="561" mass="57631" checksum="39274C0E769427CE" modified="2015-07-22" version="1">MTPTGTGDRFDAFRALADRSGRPGQRLLESLAGRRAGTGEDPGAWAPAIAADMGLPAAAGLGPATYYEDLAAPHGRRHVRVCTATACFAARSGRHLGEVEQALGVRAGTASPDGEASLQSVRCLGYCYAGPAALDGDTPCTGPTLTRQLTGREPARTPGIPAADGTGDPVLLGGAVAGEPAWRVWPRIVGTGAADEVRAQVAVSGLRGRGGAGFRVAAKWEAAGQARGSVVVANGDEGDPGSYADRLLLEADPERVLEGLALACFACGAERGVVLVRSEYPHALARMRDAVEQGYAEGHFGPSVHGTDVTLHVEVAEGAGSYVAGEETALIAGLEGDRGCARPRPPYPTQRGLWDAPTVVNNVETLASVPWIVARGGEAYARRGVPGETGTKLVCLSERFVRPGAYEVELGTPLLRIVAELGGGLKDGGEPAAVQVGGPLGGFLGPDDLDVPLTTAGLAARGAALGHAGLVAFDHRVAPEEVLRHVWQFAAAESCGACSPCRVGARRGLELAAAGAPPGPEWDRLGRVLAEASLCAFGRRIPPAVHSLARAYGDRLAGWAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAR6</accession>
    <name>A0A0F7NAR6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_29070</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018854.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_29070"/>
    <dbReference type="EnsemblBacteria" id="AKH85625">
        <property type="protein sequence ID" value="AKH85625"/>
        <property type="gene ID" value="AA958_29070"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_29070"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6125"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HATPase_C"/>
    </dbReference>
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        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
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        <property type="entry name" value="PAS"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
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        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
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        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="3">
        <location>
            <begin position="71"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="4">
        <location>
            <begin position="144"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="23"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH85625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="407" mass="43254" checksum="D7BFF265CFA9493A" modified="2015-07-22" version="1">MSVEDHDGPGRGDVNSAQPPRTLAEAAELLRRQEAELADTRRQIAELSRELSDADHGLIALHAELEAARGAAARLAAIVTSSGDAMISLSPRRVIQTWNPGATHLLGHATDAMVGDSVDALLPEGARPAFEDALARTGSGEHAEPVETRWRHADGGLVDVSVTVSAMRDADGAVIGYSIVGQDIGRRLALQSELAAARAEREVMADRERIARDLHDMVIQRVFAAGLTLQGVTPLRDNDRATARIEGVIAELDATIQELRNAIFDLHRAPQEATSLRAQIFDATSAARRNLGFAPTVSFEGPVDAAVPDEVAVHLVAVLREGLSNIGKHAQASAAEVSLHTGEELLLTVGDNGRGLGPSTRRSGLANLRERAVALGGTFEVSDRPSGGTRLVWRVPLARQRRGPDGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAT5</accession>
    <name>A0A0F7NAT5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DEAD/DEAH box helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_26510</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_26510"/>
    <dbReference type="EnsemblBacteria" id="AKH85191">
        <property type="protein sequence ID" value="AKH85191"/>
        <property type="gene ID" value="AA958_26510"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_26510"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5579"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013701">
        <property type="entry name" value="DEAD/DEAH_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08494">
        <property type="entry name" value="DEAD_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="35"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="3">
        <location>
            <begin position="271"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1424"/>
            <end position="1472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH85191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="1599" mass="169812" checksum="2205D4BE8A0FAA14" modified="2015-07-22" version="1">MVHMARSVLETFDPATRAWFEGAFAAPTAAQEGAWRALGEGSDVLVVAPTGSGKTLAAFLSALDGLTSAPPPAEARKRCRVLYVSPLKALAVDVERNLRSPLTGIRQEAVRLGRPEPEVRVAIRSGDTPAAERRSIANRPPDILITTPESLFLMLTSASRDALAGVETVILDEVHAVAGTKRGAHLALSLERLDELLPRPARRIGLSATVRPVEEVARFLSPGRRVEVVQPPSEKRFDLSVVVPVEDMGELGGSPAQDDGAGGDRPSIWPHVEERIVDLVEKHRSTIVFANSRRLAERLCNRLNEIAYERAAGEPVAEDAPPPAGIMAQSGAAQGAPAVIARAHHGSVSKEQRAQVEEDLKAGRLPAVVATSSLELGIDMGAVDLVVQVESPPSVASGLQRVGRAGHQVGAVSRGVVFPKYRGDLVQSAVVTERMREGAIEALRIPANPLDVLAQQIVAMTSMDVWDVEELLALVRRAAPFAALPESAFTAVLDMLAGRYPSDAFAELRPRLVWDRVAQTVKGRPGAQRLAVTSGGTIPDRGLFGVFLAGADPKKGGGRVGELDEEMVYESRIGDVFTLGTTSWRIEDITRDRVLVSPAPGVPGRLPFWKGDQLGRPLELGRALGAFLRELSGMDRQAAQERLRAAGLDAWAAGNVIAYLEEQRAACGHVPDDRTIVVERFRDELGDWRVVVHSPFGAQVHAPWALALGARLTERYGMDAQVMHADDGIVLRLPDTDLMGLDLLDVDPAGGRTAADAAGDDGRSPVGAADVLFDKGEVDQVVTDQVGGSALFAARFRECAARALLLPRRDPRKRTPLWQQRQRASQLLQVASEFGSFPIVLEAVRECLQDVFDVPGLTELMGDVENRRVRLVEVTTQEPSPFARSLLFGYVAQFLYEGDSPLAERRAAALSLDSRLLAELLGQAELRELLDAEVLAELERELQWRTDDRRLKDAEGVADALRVLGPLTDEELAERGAEPAWVRELEGARRAIRVRLAGTAHWAAVEDAGRLRDALGTALPVGVPEAFTEPVADPLGDLLARFARTHGPFTSGQAAARFGLGAAVTDGALHRLAAAGRTVQGEFHPAGIGQEWCDAGVLRRLRRRSLAALREELEPVAPAALAAFLPQWQHLGTHSLRGLDGLVRAVEQLQGAPVPASALEKLVLPSRVAGYVPTMLDELTNSGEVVWAGAGALPGKDGWISLYPADSAPLLLHEPHPLEVTPLHQAVLAALTGGYGLFFRQIAEQVRATHPDATDAQLADAVWDLAWSGRLTNDTLGPLRALLGSGRTAGATAHRAKRPTPRGRYGSLAVAGDARTASRNGPPTVSGRWSLLPEREPDTTHRAHALARTLLDRHGVVTRGAVAAEGVEGGFSAAYRVLSAFEETGQARRGYVVEGLGAAQFAMDGAVDRLRAVATSRERGAVEAAAAGQAGQAGDDGFVDEEGPAGPYGGHTLGGGRPRGGGPRPYGAGGAGRGGQRALVLAAADPANAYGAALPWPEPPPGTTHKPGRKAGALVVLVDGDLALYVERGGRTLLAWPPADDPRLAAAADALAAAARGGALGRTATVERINATAALDSPLGTLLEQSGFLATPRGLRIRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NB84</accession>
    <name>A0A0F7NB84_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chemotaxis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_27500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018590.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_27500"/>
    <dbReference type="EnsemblBacteria" id="AKH85356">
        <property type="protein sequence ID" value="AKH85356"/>
        <property type="gene ID" value="AA958_27500"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_27500"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5794"/>
    <dbReference type="OrthoDB" id="1727546at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041289">
        <property type="entry name" value="Bact_RF_family3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18845">
        <property type="entry name" value="baeRF_family3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH85356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="365" mass="39616" checksum="61F2EEE1CACEE914" modified="2015-07-22" version="1">MDTSLTPTALAELRERRPYPAVSLTLPTHRRAPRNAEDSVRLRNVIAEAERQLDRDPGVTRAAREEIRAQLAAAVEETDLSLALDGLVIFATVAEHRVFALPRAVPERVVLADSFLTRNLVAAYAAQRPYWVLSLAADRVTLWSGSGERVTEATAGGFPMTRTVDNPDTEREERIGDTPSKFRDEEVRTFLRDADAALHAVLAQDPRPLYATGEDAALALLAGTGTASATAVHIHHGGLAQGPPDAVARAVAPARETQARQHAAAAIAALDDARGRRAFAGGVDEVWSKVTDGRVHRLVVEENYRVTVRSADDDHLVPAEDDDPQARHDIVDEIVEQALDTGADVTFVPDDALADHERIAAVLRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBI2</accession>
    <name>A0A0F7NBI2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cupin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_24390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018081.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_24390"/>
    <dbReference type="EnsemblBacteria" id="AKH84829">
        <property type="protein sequence ID" value="AKH84829"/>
        <property type="gene ID" value="AA958_24390"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_24390"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5141"/>
    <dbReference type="OrthoDB" id="1928636at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="1">
        <location>
            <begin position="37"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="170" mass="18877" checksum="CE82BCC56D1D3D71" modified="2015-07-22" version="1">MTSLVVPPGQGRKLITKAQEVTFKVTGADNGFASTFEVVVPPGFDVGAHVHEDAKEFFYVLEGELELFAFEPVARTEDTWHNWESPEGGKPLRAGPGSCMFVDSGTPHAFRNPTSTPTRMLFQSSPPPDHERYFEEICEIFSSGKTVDPGAVQLLRDRYDVKQITPLRYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBN1</accession>
    <name>A0A0F7NBN1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sugar ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_28855</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_28855"/>
    <dbReference type="EnsemblBacteria" id="AKH85591">
        <property type="protein sequence ID" value="AKH85591"/>
        <property type="gene ID" value="AA958_28855"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_28855"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6080"/>
    <dbReference type="OrthoDB" id="1378040at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peripla_BP_4" evidence="2">
        <location>
            <begin position="47"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH85591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="339" mass="36114" checksum="3C98C5D0E980FE56" modified="2015-07-22" version="1">MLFGAAGVSAAAFLTSCTSNDDSDDEGGSEQQQANVSDDKPGKPVTIGFAGPEADHGWLNAINDNARSRAEKYEDVTLDITEGSNDTATQIGQVDSLINKKVDVLVILPADGKAMTQAGLKAMRAGIPVVNLDRIFNSPQAYRCWIGGDNYGMGLNAGRFIGEQLKGKSNAKVVELAGLDNLELTQQRTKGFDDALKNYPNIEKVARQAAEFTVESGQRKMSDLLQAVPEFDAIWNHDDDQGVGVKRAIDQSGRDEFIMVGGAGSKAVMDSIKADDSVIKATVLYPPTMAASAIDLARALGQQKGVSGMAEFEIPASITLYSAVVSKDNIDQYLPTGFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBR8</accession>
    <name>A0A0F7NBR8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">YrdC-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_24825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018145.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_24825"/>
    <dbReference type="EnsemblBacteria" id="AKH84893">
        <property type="protein sequence ID" value="AKH84893"/>
        <property type="gene ID" value="AA958_24825"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_24825"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5234"/>
    <dbReference type="OrthoDB" id="1913202at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006070">
        <property type="entry name" value="YrdC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01300">
        <property type="entry name" value="Sua5_yciO_yrdC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="SSF55821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00057">
        <property type="entry name" value="TIGR00057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51163">
        <property type="entry name" value="YRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YrdC-like" evidence="1">
        <location>
            <begin position="14"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="215" mass="22442" checksum="B87B1C8B1477554C" modified="2015-07-22" version="1">MARRYDCSDAADRRTGLREAASAVRRGELVVLPTDTVYGIGADAFAGEAVAALLDAKGRGRSMPTPVLIGSPNTLHGLVKDLSEEAWELIDAFWPGALTVVAKHQPSLTWDLGETRGTVAVRMPLHPVALELLKEVGPMAVSSANLTGHPAPQDCDAAQEMLGESVSVYLDGGPTPAAVPSSIVDITGRTPVLLREGAVTAEQLREVAGGLEVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBS1</accession>
    <name>A0A0F7NBS1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Arsenate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_20440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017451.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_20440"/>
    <dbReference type="EnsemblBacteria" id="AKH84162">
        <property type="protein sequence ID" value="AKH84162"/>
        <property type="gene ID" value="AA958_20440"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_20440"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4308"/>
    <dbReference type="OrthoDB" id="2057744at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH84162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="132" mass="13695" checksum="A5F3A81BF1855A52" modified="2015-07-22" version="1">MSDLAWVPRSCTLPTAERPLRVAEWDALFAAGPVSLSRPEPLRLRLVLAGGPEVGERVRDLAERESGCCSFFTFTTGTDTGSGTGADTGTGTAAGRGGDCTAVRLWLDIAVDPAHAAVLDALAARIDAVAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-08-12" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBT9</accession>
    <name>A0A0F7NBT9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_24805</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LytR/CpsA/Psr (LCP) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018141.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH84889">
        <property type="protein sequence ID" value="AKH84889"/>
        <property type="gene ID" value="AA958_24805"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_24805"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5230"/>
    <dbReference type="OrthoDB" id="491753at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004474">
        <property type="entry name" value="LytR_CpsA_psr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03816">
        <property type="entry name" value="LytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00350">
        <property type="entry name" value="lytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="LytR_cpsA_psr" evidence="4">
        <location>
            <begin position="98"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="337"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH84889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="382" mass="40582" checksum="3E5241B4663033A3" modified="2015-07-22" version="1">MTEPYDDGDPGHRPRGRRRKAVLVAVWTLVGVMVLGGAGFTYLYFRLNGNLTSVDLDAKLGGDRPEDLPNGSTDILVLGSDSRAGDNAKYGRDGGGARSDTAMIVHVYEDRKRASVVSIPRDTLVDRPECSRDDGDTAPAAKRAMFNESYSVGGPACTVKTVEKMTGVRMDHFVEVDFSGFKRLIDQLGGVEITTRQDIDDPDSHLDLKAGTHTLDGEEALGLVRTRKGVGDGSDLGRIELQQVFVKALVQQVGQVDLLTSPGKLIGLADTATKSITTDDGLGTVNKLRRLAESLGDIGPNDMRMATLPVTADKQDSNRVVPKEKEAAQVWKALREDRPIPKSALKGDAGGQGERDVVAAPPAPGDGLEEVAPGGGAQAAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCB1</accession>
    <name>A0A0F7NCB1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dimethylallyltranstransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_32210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019343.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_32210"/>
    <dbReference type="EnsemblBacteria" id="AKH86115">
        <property type="protein sequence ID" value="AKH86115"/>
        <property type="gene ID" value="AA958_32210"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_32210"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6801"/>
    <dbReference type="OrthoDB" id="1861068at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH86115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="364" mass="38745" checksum="F850C1144834C09F" modified="2015-07-22" version="1">MPRPEPDTDTAATPGAAEVLALLDHARELTNPVLRTVVDRLVPPMDTVAAYHFGWIDAQGDPADGDGGKAVRPLLSLLAAEAAGASPETGVPGAVAVELVHNFSLLHDDLMDGDEQRRHRDTVWKAYGPAQAILVGDALFALACELLLELDTPEAARAARRLNTATRRLIDGQAQDISYEHRESVSVAECLEMEGNKTGALLACACSIGAVLAGAGDEAADGLERFGLHLGLAFQAVDDVLGIWGEPAVTGKQTWSDLRQRKKSLPVCAALAAGGPASAELAKTLAADAQRADGRNTDAKSDFDEEEFAARAALIEEAGGRRWTQEEAQRQHESALASLDGVKMPEDIRERFVALADFVVVRRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-10-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCE6</accession>
    <name>A0A0F7NCE6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_32480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86155">
        <property type="protein sequence ID" value="AKH86155"/>
        <property type="gene ID" value="AA958_32480"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_32480"/>
    <dbReference type="OrthoDB" id="332662at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH86155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="75" mass="8770" checksum="6D08E1B4FD5E065F" modified="2015-07-22" version="1">MDRGRHHSLTHRTTFTAVFRPTVLTMQTLRQDRIRDEALEVDDPLHLMRLFGISSQTAMRYLTAAHPERTAKLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7ND43</accession>
    <name>A0A0F7ND43_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_23400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017917.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_23400"/>
    <dbReference type="EnsemblBacteria" id="AKH84662">
        <property type="protein sequence ID" value="AKH84662"/>
        <property type="gene ID" value="AA958_23400"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_23400"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4933"/>
    <dbReference type="OrthoDB" id="635734at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022622">
        <property type="entry name" value="DUF3492"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11997">
        <property type="entry name" value="DUF3492"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DUF3492" evidence="1">
        <location>
            <begin position="5"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="561" mass="58443" checksum="074A70717731C176" modified="2015-07-22" version="1">MFSLRIGLLAEGGFPFAAGESPGWCDRLVRGLAHHEFDVFAFAVDAAQESSGLVPLPPQVRAVHVAPLWRPAPGERRYGRAERRRFAEHFAELAGALAAGGAGEFPGWEPGRESGQDRFTSGLYGLAELARDAGGPGRALREEEAVRILERACRAPGVPPVVRGARVAELLAVAAHLDRALRPLGAGWYGDGGAGLAGADLCHALSAGPAALPGLLARRFFGTPLLVTEYGVRLRRHYLESGWGAYAGGTVTVRALAAAFHRRLAAEAYDKAALVTPGNAHARRWALRLGAAGHRLRTVYPGMDAARFAEVADLPAAGDDRTLVWAGRIEPAGDLIALLHAFAEIRREEPAAHLVVAETGPPAAAHAGYRDHCRALAAQLFPDEAADAHAVGASPVSFEQIGDPALPDRTAAYAAGGVSVLSSVVAGFPVGLVEAMLCGRATVSTDVGAVREVIGGTGLVVPPRNPRALADACLSLLRDPARRARLGAAARARAVELFTAEQNVDAFGSLYLELASHGPALAPARATPHPFAHPPEAYLAAAPVPDAGRPGAGPVLEGADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDA7</accession>
    <name>A0A0F7NDA7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GCN5 family acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_00895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_00895"/>
    <dbReference type="EnsemblBacteria" id="AKH86470">
        <property type="protein sequence ID" value="AKH86470"/>
        <property type="gene ID" value="AA958_00895"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_00895"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.199"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013653">
        <property type="entry name" value="FR47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08445">
        <property type="entry name" value="FR47"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="99"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="223" mass="22694" checksum="B41061BA7479DD25" modified="2015-07-22" version="1">MTTPGYGTGGPDGGRLAALLAAAARGDFPPPDGAVTVLPQPSPRDAGVLALTGSHVVFADADPAWIRGLLPAGDLSAPLNPPFLSALSARLGRTVNNIDALLVADPLPGPPPLPLAPDADGTHPRLRRALRHRDGVRAWTVPGATVLLGRGVAGRWEAAVEVGPEAQGRGLGRRLAAAARHLVPPGEPLWAQVAPGNAASVRAFLAAGFRPAGAEALLMVDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDT2</accession>
    <name>A0A0F7NDT2_9ACTN</name>
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        <submittedName>
            <fullName evidence="2">XRE family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_33795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="protein sequence ID" value="AKH86381"/>
        <property type="gene ID" value="AA958_33795"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_33795"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.7137"/>
    <dbReference type="OrthoDB" id="922937at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="34"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="277" mass="29502" checksum="A4ABDE16B6D3DDF4" modified="2015-07-22" version="1">MARTELGAFLTARRAGVTPAAANLPVTGERRVPGLRREEVALLAGVSADYYVRLEQGRERSPSAQVLDALAAALRLDEDGRLHLFRLAGLGPRARAAAVPDRVEPSLLALMDAWPHNPAVVHNRAYDVLASNAIADALFLGWSHSRNLMEVVFTDPAARSFYRDWHDVARNSVAGFRLGHGAAPGDPRVRQVLAGLLESSPEFAELWARHDARGKALEHKRFAHPAVGPLTLTMQAFGVRAAPGQELVVYHAEPGSPGAEALALLGSLAAAPGPGPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDY9</accession>
    <name>A0A0F7NDY9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_29395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_29395"/>
    <dbReference type="EnsemblBacteria" id="AKH85674">
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        <property type="gene ID" value="AA958_29395"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_29395"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6203"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="88" mass="9320" checksum="797489BBB3177BE1" modified="2015-07-22" version="1">MITATGSGYRRLGLPNEEELSGRGVHWCAVRDGFFARDRDIVVVAAATPPWKRQPSCPASPAPSPSSTAAGLDAERCLADKARALVVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NE84</accession>
    <name>A0A0F7NE84_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_04880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_04880"/>
    <dbReference type="EnsemblBacteria" id="AKH86551">
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        <property type="gene ID" value="AA958_04880"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_04880"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1027"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH86551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="313" mass="31239" checksum="AB03C62CC8E6AF6E" modified="2015-07-22" version="1">MLEVSDAVRAEIGDEEADRLVAGESAPGTYDCTSCRAPGDCAQEQTSTVLFVGEETAVLAFAHATCIPSQVVPVSEDQLQGAVRSITADEGPAPAHAPAPAPVEAHAPAALAPAVSPAPPAPVPADAPAASLAAVAPPAAPGAPAAPAASGGDHAEAQAVLGVTCGLVMCGDDARPALVVEPTAPVVRPGSEGPGDDFLPLLIESGFLPVMDMVKPPAPVTGWSVLLVTGHLHAVMQPGTAGQPPTAWWQAHQPLHVSDGWRAAAAKEQEVLVYAAPAGAIGRQPREDLLGEALAQAAARGLLVGAAMPLTGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NEA5</accession>
    <name>A0A0F7NEA5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Anthrone monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_30245</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019017.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_30245"/>
    <dbReference type="EnsemblBacteria" id="AKH85789">
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        <property type="gene ID" value="AA958_30245"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_30245"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6390"/>
    <dbReference type="OrthoDB" id="1818589at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABM" evidence="2">
        <location>
            <begin position="123"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH85789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="231" mass="26464" checksum="D28FF82138C86DE3" modified="2015-07-22" version="1">MPILSPEDKHLTVLNLFTTDKPENQDRLITEMRKIVDTAAFEGWLSSTVHAGQESPGTANFIQWRSGEDLEARYAGEEFKHRTLPVFGEITTSIRLLQNEIVYTQRHPSQGSVTEVSPDRDDFTVIEVFKTTEENQARLVEALGEGQKWLVDVEGYRSHTVFRGLRARFLEGAFAVVYSQWESKEAHDAYRTRPEADMSETRRNSEATLKSLATERDWNSYRVVHSRKAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NED3</accession>
    <name>A0A0F7NED3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_29740</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018946.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_29740"/>
    <dbReference type="EnsemblBacteria" id="AKH85718">
        <property type="protein sequence ID" value="AKH85718"/>
        <property type="gene ID" value="AA958_29740"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_29740"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6278"/>
    <dbReference type="OrthoDB" id="1179151at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032823">
        <property type="entry name" value="BCA_ABC_TP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12399">
        <property type="entry name" value="BCA_ABC_TP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="18"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="50"/>
            <end position="57"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH85718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="262" mass="28187" checksum="38F28DAF6A1CFF88" modified="2015-07-22" version="1">MAHTSTVPSEPAGRAPVVQVRALTVAFGGLLALNGIDLAVTRGERLAVIGPNGAGKTTLFNVIAGDVTPVSGSVLIKGVECVHRPSRYRPRLGVARTYQKARALAGLTVRENIYLALAGLRGRHRALWRSSTDRRMSDEAADVARRVWLAGQLDATAGELAHGQQRQLELGMAIATRPDVMLLDEPASGLSRGERERLVELLESFDEELTLLLVEHDMDVAFSIAQRVVVMADGEQVTAGTPAQVRGDPHVHRIYLGTEAPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NEQ0</accession>
    <name>A0A0F7NEQ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_26540</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018434.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_26540"/>
    <dbReference type="EnsemblBacteria" id="AKH85197">
        <property type="protein sequence ID" value="AKH85197"/>
        <property type="gene ID" value="AA958_26540"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_26540"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5585"/>
    <dbReference type="OrthoDB" id="944044at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002549">
        <property type="entry name" value="AI-2E-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21716">
        <property type="entry name" value="PTHR21716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01594">
        <property type="entry name" value="AI-2E_transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="62"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="142"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="250"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="299"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="367"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH85197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="391" mass="42247" checksum="7DBAE3BAAEDAE44F" modified="2015-07-22" version="1">MPPWLPRAIVLALGLFACFHVAEWAFHELYGLLLNILVAFFIGLACEPAVDRLAARGMRRGAATALVFLGVLAAAAAFVAALGSLVADQVRLIVENFPAYVESLVEWINEQFGTELRVDDLQQDFLKSEVVRDYLQRSADNVWGISTTVLGGLFTALTVVLFAFYFTAEGPRLRRAICSVLPPARQAEVLRAWEIAVAKTGGYLYSRGLMAIVSGIAHYIAMLLLDVPYAPALAVWVGVVSQFVPTVGTYIAGALPILLAFTVGPWTAVWLIGFVILYQQLENYLLQPRITAKTVNIHPAVAFGSVIAGAALLGAVGALIAIPATATLQAFLSAYVRRYEVDARVQEQRPLRRRGPARLTRIRALLRHPGAPPGANPGREPADAGDAPRAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NER4</accession>
    <name>A0A0F7NER4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_15170</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020085.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86786">
        <property type="protein sequence ID" value="AKH86786"/>
        <property type="gene ID" value="AA958_15170"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_15170"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3196"/>
    <dbReference type="OrthoDB" id="1210653at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="241"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="331"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="358"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="1"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="393"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH86786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="416" mass="42453" checksum="697BE4363DDE8E81" modified="2015-07-22" version="1">MLMATATGLSVAGNYFAQPLLDLIGRDLHVGSTLAALVVTAAQTGYALGLILLVPLGDVTDRRRLSVGLFVATAAFLALTAAAPNGPVLLAGTVLTALASVGAQVVVPYAAGLAAPEERGRVVGVVMSGILLGGLLARTASGALSELGGWRTIYWVNALLMAGMAVLLHRHLPRLPAAGAGMARMSYPALLRSTVALLREEPVLRRRSALGALSLASYSVQLTALTFLLARPPYGWSESAIGLFGLVGAVGVVTMTFAGRLSDRGHVQAVTGAGVLLLTGSWVLLGVAGESLPWLVVGIVGLNVAQQAVLNSNQAVVYAIRPDARNRINSAFMTSFFAGGAVGSALTSVVWARGGWQAVSALGAVLAAGTVVLWVAERVGEVRTARDAARTGAAGGVRAGARPAQDDAGPRHAPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NF08</accession>
    <name>A0A0F7NF08_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">4-hydroxyphenylpyruvate dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_31850</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="5">Binds 1 Fe cation per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the 4HPPD family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019277.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_31850"/>
    <dbReference type="EnsemblBacteria" id="AKH86049">
        <property type="protein sequence ID" value="AKH86049"/>
        <property type="gene ID" value="AA958_31850"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_31850"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6726"/>
    <dbReference type="OrthoDB" id="402639at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003868">
        <property type="term" value="F:4-hydroxyphenylpyruvate dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009072">
        <property type="term" value="P:aromatic amino acid family metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07250">
        <property type="entry name" value="HPPD_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08342">
        <property type="entry name" value="HPPD_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005956">
        <property type="entry name" value="4OHPhenylPyrv_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041735">
        <property type="entry name" value="4OHPhenylPyrv_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041736">
        <property type="entry name" value="4OHPhenylPyrv_dOase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11959">
        <property type="entry name" value="PTHR11959"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009283">
        <property type="entry name" value="HPP_dOase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01263">
        <property type="entry name" value="4HPPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="VOC" evidence="6">
        <location>
            <begin position="15"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="6">
        <location>
            <begin position="170"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="333"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR009283-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH86049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="368" mass="39164" checksum="E7AA079DE9F18494" modified="2015-07-22" version="1">MHDFSEAGVPFGDVAIDYVEMYVGSLEAAAFDWVDKYAFSVVGTGGSPEHRSIALRHGRITLVITQATSDQHPASAYVQAHGDGVADIALRTADVRAAFGAAAAGGARVVREPTAHDGDGPAVTAAIGGFGDVVHTLVQRTPRAGAGLPVGFAPALREDDGRADAVGLDEIDHVAVCLDTGSLDPTVDFYRQALGFEFVFEERIVIGSQAMESKVVQSRSGAVTLTLIQPDPTADPGQIDEFLKGHEGSGVQHLAFSSADAVRSVRTLARRGVAFLTTPGSYYDMLGSRIPSLSQARLTDLRATNVLADEDHDGQMFQIFTASSHPRHTLFFEVIERQGAQTFGSANIKALYEAVELERTGQRGPSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NF98</accession>
    <name>A0A0F7NF98_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AA958_32400</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019371.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86144">
        <property type="protein sequence ID" value="AKH86144"/>
        <property type="gene ID" value="AA958_32400"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_32400"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6839"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="19"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="279"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="380"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="409"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH86144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="605" mass="61406" checksum="2AD61089FD3DA921" modified="2015-07-22" version="1">MQLGDNGAEGPGRILAGRYRVVTQLGRGGMGTVWRAVDERLGREVAVKELRAFSDSDARDLAEMRLRTEREARAAARVRHPGVVAVHDVTEHDGRPVIVMELVDGPSLDDVLRERGGVTPAEAAQIGLKVVDALGAAHRAGVLHRDVKPGNILLERGGRVVLSDFGIAAMEEPADGNSTHLTRSGELVGSLDYLAPERARGEQPGPPSDLWSLGATLYAAVEGISPFRRTSTWSTITAIIVDPLPEPRRAGPLAPVLQALMAKDPGERADVDRARALLEPIAGTAGPPAAQGPDTVRLGRVPAAPPSGAYGPPAGLAAPGAAAPQGQFGPPQLGPPGTESRTAEQTAPQRRRGGRRWVPVAAAAAAVLLAGGGVTYALAGGDDGEPAAREETEEPAAEVVSPSPGTGDEGKEQDGKGEKEGKEGKEGKDDKDDKGGEENGPAADGDGSPEEEGAAGGGTGGTDGGGDSGADDGSGGSGSDGGSTGDGSGSGGGDAGGGSTSGGGTGDGSAPDPSCTPIGGGKYNCEVWRTASSYDAAHNPVGTLYAGTNYFFCQEKKSYRETSGEWTNVWWGKTDDDSGNAGVWVSVVYIRGGANDAPVPGLPVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFE4</accession>
    <name>A0A0F7NFE4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Superoxide dismutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_23785</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020362.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_23785"/>
    <dbReference type="EnsemblBacteria" id="AKH86996">
        <property type="protein sequence ID" value="AKH86996"/>
        <property type="gene ID" value="AA958_23785"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_23785"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5013"/>
    <dbReference type="OrthoDB" id="1789560at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.400">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036502">
        <property type="entry name" value="NiSOD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014123">
        <property type="entry name" value="Superoxide_dismutase_Ni-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09055">
        <property type="entry name" value="Sod_Ni"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109770">
        <property type="entry name" value="SSF109770"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02753">
        <property type="entry name" value="sodN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH86996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="131" mass="14725" checksum="4F75680BF538837E" modified="2015-07-22" version="1">MFSRLFAPKVTVSAHCDLPCGVYDPAQARIEAESVKAIQEKMQGNDDPHFQARATTIKEQRAELAKHHVSVLWSDYFKPPHFEKYPELHQLVNDTLKALSAAKGSTDPATGQKALDYIAQVDKIFWETKQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFJ9</accession>
    <name>A0A0F7NFJ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Iron-sulfur protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_28210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018711.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_28210"/>
    <dbReference type="EnsemblBacteria" id="AKH85477">
        <property type="protein sequence ID" value="AKH85477"/>
        <property type="gene ID" value="AA958_28210"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_28210"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5946"/>
    <dbReference type="OrthoDB" id="1266811at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024726">
        <property type="entry name" value="FhuF_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11575">
        <property type="entry name" value="FhuF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FhuF_C" evidence="1">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="299" mass="31391" checksum="919D63727A88D406" modified="2015-07-22" version="1">MSAPAVPQPLADAGAPPARPAGTPVTAAYARLSEVLPFLAVTELGTADPLPAGPGWVAAADLAAGGPALDDFLAWDAEQVRRTYGEEARPDVVASFGLHRYAWSACLLVTLPWFLLRRVPRVPLEAVALHRNADGSRMRLAVHGGAFACLPDDPAAGLPGARVVAGEEALRAEVRAAVAEHLEPVLAAFGPRMRRGPRALWGMATDEIVEGLWYLGDLLGEEERAMAETGQLLPGTGGATAPYAGGAAFRTLTGPAGQSLATRDRASCCMYYTLRPEDTCVTCPRTCDTERVARLVASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFN3</accession>
    <name>A0A0F7NFN3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_28510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018766.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_28510"/>
    <dbReference type="EnsemblBacteria" id="AKH85532">
        <property type="protein sequence ID" value="AKH85532"/>
        <property type="gene ID" value="AA958_28510"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_28510"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6007"/>
    <dbReference type="OrthoDB" id="1636579at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH85532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="180" mass="20263" checksum="4ACEB287C64EAC5C" modified="2015-07-22" version="1">MHHRPPRRVARSWKAYLAIALLVGIPLVYGWISTQQSRESGRDKAERAAFTDMEPGWPPRLLRRIYQVPVPGGAENIRYYEQNALHDSALYVDFTAPQESVDEYLETTLSRSDVRPLPRLKDGLNPVTPAQADTVGWDFTEGDWSGLKLKQSGARPDVSIVVNTADPENLVVRTVSTTEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFR1</accession>
    <name>A0A0F7NFR1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_30305</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_30305"/>
    <dbReference type="EnsemblBacteria" id="AKH87141">
        <property type="protein sequence ID" value="AKH87141"/>
        <property type="gene ID" value="AA958_30305"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_30305"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6402"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="261"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="291"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="325"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl_transf_3" evidence="2">
        <location>
            <begin position="2"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH87141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="376" mass="42040" checksum="E40CB6405B7C2CAC" modified="2015-07-22" version="1">MPSLTGLRFAAALLVFLNHVGLPFPHSRLLESDSAAMNLFDVTGNAGALGVTFFFVLSGFVLTWSARERDSAPRFWRRRIVKIYPNYAVTWLLAMVLFASAYTSTGTAVANLFAVHMWSTDFAVYSSVNQPSWSLGCEIFFYACFPLLHNLFQRIPTAHLKYWIASVTAGAMATPAVAYAWITDWPLFPGAALDAPVSSEQYWFANFFPATRILDFVLGMLVAHAVIRKRWFNIGMLWSGLLLAGSYVLCSYVPFLYSQRSITVIPMCLFIAAAAIADIQGKRSVFRNRVMIWLGEISFAFYLIHFIVLAYLRKEIDGFFSVPETVGLVTFALVVSVLASWAMYTLLERPITRRFSSPRSAVTVQKGELSTPVTKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-12-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFY3</accession>
    <name>A0A0F7NFY3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_33560</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019561.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86339">
        <property type="protein sequence ID" value="AKH86339"/>
        <property type="gene ID" value="AA958_33560"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_33560"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.7087"/>
    <dbReference type="OrthoDB" id="1832218at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="PTHR21240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="2">
        <location>
            <begin position="4"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH86339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="280" mass="31005" checksum="4BDBF7AF10C0F34D" modified="2015-07-22" version="1">MITDVHSHLFRPGTDFDDGFRTEAARAHAGEVDLTVRWAEYAAAAPDDTRTIVVGGKARRSGLWVDDAAVAAYTAAHPGRLVGYLSLDPTQPGWRDELRHGHQELGLRGIKLMPMYAGFDPAAEEYDDLFGYAERHGLPLLVHTGTTFVSAAPLEYAMPRHLDAVAIRHPGLRMVLAHLGHPFEGECLAVIRKHPHVYADVSALHYRPFQLWHSLRLAQDYGVWHKLLFGSDYPFTTVDASVAGLREIARIPGIPGLPPLDRDEVEKLIHRPALDLLGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NGW5</accession>
    <name>A0A0F7NGW5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Na(+)/H(+) antiporter NhaA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Sodium/proton antiporter NhaA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">nhaA</name>
        <name evidence="11" type="ORF">AA958_31380</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>2 H(+)(out) + Na(+)(in) = 2 H(+)(in) + Na(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29251"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019200.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH85972">
        <property type="protein sequence ID" value="AKH85972"/>
        <property type="gene ID" value="AA958_31380"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_31380"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6631"/>
    <dbReference type="OrthoDB" id="1805428at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015081">
        <property type="term" value="F:sodium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006885">
        <property type="term" value="P:regulation of pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01844">
        <property type="entry name" value="NhaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023171">
        <property type="entry name" value="Na/H_antiporter_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004670">
        <property type="entry name" value="NhaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30341">
        <property type="entry name" value="PTHR30341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06965">
        <property type="entry name" value="Na_H_antiport_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13462">
        <property type="entry name" value="Thioredoxin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00773">
        <property type="entry name" value="NhaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0050">Antiport</keyword>
    <keyword evidence="5 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0915">Sodium</keyword>
    <keyword evidence="9" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="108"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="168"/>
            <end position="191"/>
        </location>
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        <location>
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        </location>
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            <end position="322"/>
        </location>
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        </location>
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        <location>
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            <end position="429"/>
        </location>
    </feature>
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            <begin position="426"/>
            <end position="621"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AKH85972.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="634" mass="68065" checksum="7695E17A04FAAC51" modified="2015-07-22" version="1">MAQPDAATDADRTVGVRPTASARWTFIRTESGSAAFLVAAAVAALVWANVAPGTYTDFWHTHLTFALGDHALSLDLREWVNSGLMTVFFLVIGLEVRREFDMGELRELNRVTLPFMAGLAGMVVPVLIFLAFNAGDSAASGWGVAMSTDTAFALGMLALLGKRFPRRLYTFVLTIAVVDDFVVLAVIALVYSGNVHWPPLLVGAVFFAAIIGLRSAGSRRGPVYAALAVAMWLAFEESGVDPVVVGLLIGLMTFAYPAPRSELERATGLFRSFREQPTPELEREARMGIASAISPNERLLRMYHPWSSYLVVPLFALANTGIELNGSVLSSAVTSPLTLGVFLAFVVGKPLGVVGATALTTWWSKGRLRPPVGWASVAGGGAITGIGFTIAVLIATMAFSGKELEEAKIGILAAVLGSVLVTALVALVATRLPKQRRIRALLGTAPVIVDLAVPVDADRDHIRGPREAPVTVVEYGDFECPYCGRAEPVVRDLLADFGDIRYVWRHLPLTDVHPRAQLAAEAAEAAAEQGAFWPMHDRLLDHQDRLTPLDLVAHATELGLDADRFSEAMRARDGAARVDEDTESADLSGVAGTPTFFVNGRRHRGAYDIAGLSAAVRAARARAMLDEEDAEDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NHD4</accession>
    <name>A0A0F7NHD4_9ACTN</name>
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        </submittedName>
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    </gene>
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        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="18"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="286" mass="30711" checksum="BF69740DD3663455" modified="2015-07-22" version="1">MPDYGHDLRFGINLIPSSQAPEATVALAQLSERAGADLITFQDHPYQPAFLDTWTLLSYVAARTDSVTLSGNVHPLPLRPPALLARSAASLDLLSGGRFELALGAGGFWDAIAALGGPRRSPGEAVEALDEGIRIIRDTWDTETRGGIRFDGRHYQVRGAKRGPRPAHDMQIWLGAYKARMLRLVGRAADGWLPSLPYLDSPAVLADGNAVIDEAAVAAGRAPGDVRRLLNLGEEHPADQLAEFALTYGTGTFLIMTSEPREIERFLGEVAPAVRELVAESRGSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
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        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
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        <location>
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            <end position="45"/>
        </location>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH86874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="129" mass="14225" checksum="FB8716911B8614CF" modified="2015-07-22" version="1">MTNVELARRVGLTPPPCLRRVKRLEEAGIITGYRARVDEEAAGRGLEVIVSIEVSVSDLDTLAGLEATIGAYDEVVEFRRVFGTPDYFLRVLVADYAAYERFQTGKIIGIPGVARVISQPTMKKIKVVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-12-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NHK3</accession>
    <name>A0A0F7NHK3_9ACTN</name>
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        </submittedName>
    </protein>
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    </gene>
    <organism evidence="2 3">
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_19535"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4117"/>
    <dbReference type="Proteomes" id="UP000034283">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="130" mass="13793" checksum="948D8965C485B33C" modified="2015-07-22" version="1">MARGLKPLGVTPAQAEVVRLLAERQPLTLSGLGSLLVCESGSNPSRLVDRLVTAGLVRREEAPHDRRHVELTLTPAGHQTARGVAQVEAALHARIADAASAHDLQAVRDFLRALVAGESSGEAIERRAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NI05</accession>
    <name>A0A0F7NI05_9ACTN</name>
    <protein>
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        </submittedName>
    </protein>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_33855"/>
    <dbReference type="EnsemblBacteria" id="AKH86392">
        <property type="protein sequence ID" value="AKH86392"/>
        <property type="gene ID" value="AA958_33855"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_33855"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.7149"/>
    <dbReference type="OrthoDB" id="1860541at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="SSF52499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase" evidence="1">
        <location>
            <begin position="18"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="218" mass="23427" checksum="6D2CB62540B6BDA8" modified="2015-07-22" version="1">MSTENKAGLDALLTPEESVLVLIDHQPFQFANLNSHEPTMVVNNVVGLAKAAKVFGVPTILTTVLEERGGLLLQGVQDVFPEQKPVNRTFINTWQDERVVEAVRATGRKKLIIAGLWTEICVAMPAIQAAGEGFEVFVVTDASGGVSKEAHDMAVRRMVQAGVVPITWLAVMGEWQRDWAREKTVAGAAEVQAQHGGASGVAFAWELQLLATPTGSEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NJH1</accession>
    <name>A0A0F7NJH1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NADH-quinone oxidoreductase subunit M</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_20770</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 3">Membrane</location>
            <topology evidence="1 3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I subunit 4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_20770"/>
    <dbReference type="EnsemblBacteria" id="AKH86932">
        <property type="protein sequence ID" value="AKH86932"/>
        <property type="gene ID" value="AA958_20770"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_20770"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4381"/>
    <dbReference type="OrthoDB" id="535707at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010227">
        <property type="entry name" value="NADH_Q_OxRdtase_chainM/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003918">
        <property type="entry name" value="NADH_UbQ_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43507">
        <property type="entry name" value="PTHR43507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01437">
        <property type="entry name" value="NUOXDRDTASE4"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01972">
        <property type="entry name" value="NDH_I_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="132"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="212"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="251"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="285"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="317"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="343"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="392"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="433"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="480"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="5">
        <location>
            <begin position="140"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH86932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="516" mass="53403" checksum="BBF37E8EE0C70A0D" modified="2015-07-22" version="1">MQLVLAAIVVLPLLGALGALFPAPPGLKGKSPDQAVLRHGVTVTGAVFVLSVVLAAGFDYDDAGTMQADSDVGWIPALGIRLHLGVDGVSLPLLVLTALLTFLCAVYGYFVMPAGPSPRAFVALLLVLEGGMLATFAVLNLLLFFLAFEMVLIPMYFLIARWGGAGRTAAAWKFILYTLLGSVVMLLGLLLVGFQGGTFDMVALATDNGAKLTHTTQLIAVLAIGVGLAVKTPMWPLHSWLPDAHTAAPTVGSVLLAGVLLKMGTYGFVRVLLPVAPDGMETYAPYLAAFGVTGILYGSLACLALARNGARGDLKRLIAYSSVGHMGFVLLGISTLTPTGVNGALFANIAHGLITGLLFFLVGALKERTGTTDLDALAGRTGAALYGSAPRLGALLVFGAVASLGLPGLAGFWGEMLAMFAAYDPAAGLPRPAYLVSMAVAGFGTLLTAAYLLVVVRRVCMGDRTPGERPAFGDVRRYEIAAWSPLVTLTVLAGLWPAALLGLTDPAVQKLLAGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NJP1</accession>
    <name>A0A0F7NJP1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_24100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020369.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH87002">
        <property type="protein sequence ID" value="AKH87002"/>
        <property type="gene ID" value="AA958_24100"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_24100"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5079"/>
    <dbReference type="OrthoDB" id="1664438at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="50"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH87002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="256" mass="27273" checksum="710AF9A7B6A4C401" modified="2015-07-22" version="1">MSTNQEAVALHRDTENLLAVIDAADRMPGATRLRDRSYELLSPVPGSTVVDVGCGAGRAVAELTDRGVHAVGVDPSTRMLAAARERWPEAEFRAAGAEELPFADGSVHGYRADKVFHVLREPARAVAEARRVLRPGGRIVLVGQDWDALMIDSDDAALTRTIVHARADLLGAPRAGRQYRGLLLAGGFADVTVEVHTSVFTDPAMLPLLARLAGPACESGAVARDRADAWLAEQRRRAEAGRFLVAVPVFVAAASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NJV9</accession>
    <name>A0A0F7NJV9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">OmpR/PhoB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_27640</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AfsR/DnrI/RedD regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_27640"/>
    <dbReference type="EnsemblBacteria" id="AKH87067">
        <property type="protein sequence ID" value="AKH87067"/>
        <property type="gene ID" value="AA958_27640"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_27640"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5824"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15831">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03704">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="2" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="847"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="241"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="241"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH87067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="937" mass="102235" checksum="A1B835F1D1955BF8" modified="2015-07-22" version="1">MELRGADGRQYPLGPPQQRCVLAVLAMAPGRPVMVETLIRHVWRGESSGAARDVLYTYVSRLRRLLRQAAQDGPYVPVLRRGNGGYALDIALESVDLQRARALAGQGRSERSDDPERAAKLFGEASALWRGTPLAGLRGEWAEQVRAGLERERVSLLTEWYDVELELGRHAESVAGLSAEVVEHPLAEPLAAQLMLALYRSGRQSDALQVYARTRASLVAGIGEEPGPELRRLHERILRRSPVLNRRQEPHGSPADEERAVPEDAPPAVRPAQLPPGVAGFTGRETYLRRLERLLPGADGGSPDASICAVVGTAGVGKTALAVHWAHRAAERFPDGQLYVNLRGFAAADSPTGPAEVLRAFLQALRIPDSQIPEGTDARTGLFRSLLAGRRMLVVLDNARDDCQVLPLLPGAPGCATLVTSRHRLPSLVAQTGADQIVLEPFSTEEARQLLVRRLTADQLEGRGDAVADIVKGCVRLPLALALAAAHLAARPGLTLTALADQTPDSGGRALTADVRTVFSWSYRILSPATARLFRLLGLHPGPEFGTGAAAALAGIELPQARSLLRELTWASVLDERAPGRFVLHDLLRDYAAELAREEDEEERRRAAVRRVLDYYLHSAHGACRTLWAHRDRLTDLGPAPSGITPETFTEAPSAYAWFTTERRTLTEAVRLAVHTDLDEHAVRLGRRLGNHLDRDGRWIEQNRLLQTVLAAARRTVGDPAGDAELAAVLCDQARSAFRLGAPDQAREHLDSAYELFRAHDDLAGQAEVHHYIANLHEVQDDPVPALRHARTSLALYRAAGDRRGQGRELNLIGWIYGLLGKPESSLARSRLALAVQESVGDLYFMGITWDTLGRAHHRLGDPHEAISCFRRALDLLESPDAADLLNAAKAHTALGDAQADTGDNAAARASWTRALRIFEDLRHPAAAEPRTRLQTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-10-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MYK4</accession>
    <name>A0A0F7MYK4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_02985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014673.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH81310">
        <property type="protein sequence ID" value="AKH81310"/>
        <property type="gene ID" value="AA958_02985"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_02985"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.637"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="214" mass="21628" checksum="40B7538D682FDF32" modified="2015-07-22" version="1">MSASPPPSAGADPPAVRVGVLLPRLPEEPAAWLAECAAYDSAGADALWLDGGPDPAHDVLALAAALAAATGRARLVVALPDHVPQAALLARALATVVLLSGGRLALAADSRRCAELGAVAPAVPAFRRLAPAGPGYEEPGAGRWTLAAAPAGPDAWRTALTGAAERGVHGLVVPAGQPLLEALRLSVSAERHTRHNRPTGARVTTERQSPHGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MZG7</accession>
    <name>A0A0F7MZG7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PTS fructose transporter subunit IIA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_01780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014470.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_01780"/>
    <dbReference type="EnsemblBacteria" id="AKH81106">
        <property type="protein sequence ID" value="AKH81106"/>
        <property type="gene ID" value="AA958_01780"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_01780"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.388"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047324">
        <property type="term" value="F:phosphoenolpyruvate-glycerone phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.510">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039643">
        <property type="entry name" value="DhaM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004701">
        <property type="entry name" value="PTS_EIIA_man-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036662">
        <property type="entry name" value="PTS_EIIA_man-typ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38594">
        <property type="entry name" value="PTHR38594"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03610">
        <property type="entry name" value="EIIA-man"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53062">
        <property type="entry name" value="SSF53062"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51096">
        <property type="entry name" value="PTS_EIIA_TYPE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PTS EIIA type-4" evidence="2">
        <location>
            <begin position="6"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH81106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="134" mass="13037" checksum="4D7E88860E8E59CE" modified="2015-07-22" version="1">MAEGPLVGLVLVSHSAAVAESVARMAVALAGVDTVAVGYAGGTADGGFGTDADRIAVAARAADRGAGVGLLVDLGSAVLTVKSLVENEELPAGARLLDAPFVEGAVAAVVTASTGADLDAVEAAAQEAYGYRKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MZS4</accession>
    <name>A0A0F7MZS4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Branched-chain amino acid ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_05950</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015173.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_05950"/>
    <dbReference type="EnsemblBacteria" id="AKH81820">
        <property type="protein sequence ID" value="AKH81820"/>
        <property type="gene ID" value="AA958_05950"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_05950"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1244"/>
    <dbReference type="OrthoDB" id="1179151at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032823">
        <property type="entry name" value="BCA_ABC_TP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12399">
        <property type="entry name" value="BCA_ABC_TP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="17"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="281"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="286"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="49"/>
            <end position="56"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH81820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="302" mass="32329" checksum="2A7D6C1EE774B6FC" modified="2015-07-22" version="1">MASDTIPAKGPDGATVLDARGVTMRFGGLTAVRNVDLTVGQGEIVGLIGPNGAGKTTFFNCMTGLYIATEGTVRYKGTVLPHRSHRVTEAGIARTFQNIRLFANMTVLENVLVGRHTRTNEGLWSALLRNPGFKRAEKASEARAMELLEFTGLAAKRDHLARNLPYGEQRKLEIARALASEPGLLLLDEPTAGMNPQETRATRELVFAIREQGISVLVIEHDMRFIFGLCDRVAVLVQGEKLVEGTPDVVQSDDRVVAAYLGTPFEGVPEDEAVAEVAAAEDAVAGNTGSGSTPKTSKEGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N094</accession>
    <name>A0A0F7N094_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glutamine synthetase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_07155</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the glutamine synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015385.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_07155"/>
    <dbReference type="EnsemblBacteria" id="AKH82035">
        <property type="protein sequence ID" value="AKH82035"/>
        <property type="gene ID" value="AA958_07155"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_07155"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1499"/>
    <dbReference type="OrthoDB" id="416474at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamate-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008147">
        <property type="entry name" value="Gln_synt_b-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027303">
        <property type="entry name" value="Gln_synth_gly_rich_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03951">
        <property type="entry name" value="Gln-synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="SSF54368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00181">
        <property type="entry name" value="GLNA_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gln-synt_C" evidence="5">
        <location>
            <begin position="104"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH82035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="453" mass="50550" checksum="7E9FFF2BAC011884" modified="2015-07-22" version="1">MEKQQEFVLRTLEERDIRFVRLWFTDVLGFLKSVAVAPAELEQAFDEGIGFDGSAIEGFARVHESDMLAKPDPGTFQVLPWRAETPGTARMFCDILMPGGSPSFADPRYVLKRILAKTSDLGFTFYTHPEIEFFLLKEKPVDGSRPVPADNSGYFDHTPQNVGMDFRRQAITMLESMGISVEFSHHEGAPGQQEIDLRYADALATADNIMTFRLIMKQVALEQGVQATFMPKPFSEYPGSGMHTHLSLFEGDRNAFHESGSEFQLSKVGRSFIAGLLRHAAEVSAVTNQWVNSYKRIWGGSQRTAGAGGEAPSYICWGHNNRSALVRVPLYKPGKTGSTRIEVRSIDSGCNPYLAYAMLLAAGLKGIEEGYELPPGAEDDVWALTDGERRAMGIEPLPQNLGEAIGLMERSEICAETLGEHVFDFFLRNKKQEWEEYRSEVTAFELRKSLPVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N095</accession>
    <name>A0A0F7N095_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">GTP pyrophosphokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_03265</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + GTP = AMP + guanosine 3'-diphosphate 5'-triphosphate</text>
            <dbReference type="Rhea" id="RHEA:22088"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:142410"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; ppGpp biosynthesis; ppGpp from GTP: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the relA/spoT family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014720.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_03265"/>
    <dbReference type="EnsemblBacteria" id="AKH81361">
        <property type="protein sequence ID" value="AKH81361"/>
        <property type="gene ID" value="AA958_03265"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_03265"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.695"/>
    <dbReference type="OrthoDB" id="204079at2"/>
    <dbReference type="UniPathway" id="UPA00908">
        <property type="reaction ID" value="UER00884"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015970">
        <property type="term" value="P:guanosine tetraphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05399">
        <property type="entry name" value="NT_Rel-Spo_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01668">
        <property type="entry name" value="TGS_RSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004811">
        <property type="entry name" value="RelA/Spo_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045600">
        <property type="entry name" value="RelA/SpoT_AH_RIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007685">
        <property type="entry name" value="RelA_SpoT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033655">
        <property type="entry name" value="TGS_RelA/SpoT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13291">
        <property type="entry name" value="ACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19296">
        <property type="entry name" value="DUF5913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04607">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00954">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="SSF81271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00691">
        <property type="entry name" value="spoT_relA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HD" evidence="6">
        <location>
            <begin position="137"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="7">
        <location>
            <begin position="485"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="5">
        <location>
            <begin position="754"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH81361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="832" mass="92669" checksum="CF3870206C2CD46F" modified="2015-07-22" version="1">MPDEAHRSTAAPPEKQRQPGAADRPLPARAAENGSGRRTAPPEGRTQPAAPARVEPASGHGGGQAGRGGSPSRVRARLARLGVQRQSPYNPVLEPLLRIVRGNDPKADTSTLRQIERAYQVAERWHRGQKRKSGDPYITHPLAVTTILAELGMDPATLMAGLLHDTVEDTEYGLEDLRRDFGDQVTLLVDGVTKLDKVKFGEAAQAETVRKMVVAMAKDPRVLVIKLADRLHNMRTMRYLRREKQEQKARETLEIYAPLAHRLGMNTIKWELEDLAFAILYPKMYDEIVRLVAERAPKRDEYLAVVIDEVQQDLRSARIKATVTGRPKHYYSVYQKMIVRGRDFAEIYDLVGIRVLVDSVRDCYAALGTIHARWNPVPGRFKDYIAMPKFNMYQSLHTTVIGPEGKPVELQIRTFDMHRRAEYGIAAHWKYKQEATGGAARQQGAGTRRGSKSEQVNDMAWLRQLIDWQKETEDPGEFLDALRFDLSRHEVFVFTPKGDVIALPAGATPVDFAYAVHTEVGHKTIGARVGGRLVPLESALDNGDTVEVFTSKAAGAGPSRDWLNFVKSPRARNKIRAWFSKERRDEAIEQGKDAIARAMRKQNLPIQRILTGDSLVTIAHEMRYPDISALYAAIGEGHISAQNVVQKLVQALGGEEAATEDIEETAPPLPGKTRKRRAVNDPGVIVKGVDDVWVKLSRCCTPVPGDPIIGFVTRGKGVSVHRADCVNVESLSQQPERIIEVEWAPTQSSVFLVAIQVEALDRSRLLSDVTRVLSDQHVNILSAAVQTSRDRVATSRFTFEMGDPKHLGHVLKAVRKVEGVYDVYRVTSARNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0B4</accession>
    <name>A0A0F7N0B4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_03470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014754.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH81396">
        <property type="protein sequence ID" value="AKH81396"/>
        <property type="gene ID" value="AA958_03470"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_03470"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.732"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="68" mass="7073" checksum="FE55FDC41F5F06C4" modified="2015-07-22" version="1">MERTAEHTARPKAVAGALAAFGAQPSERRHPLVALAMVLPLAIVLTVLFGGWEAVITHASSVAGMMGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0D1</accession>
    <name>A0A0F7N0D1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_07415</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015435.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_07415"/>
    <dbReference type="EnsemblBacteria" id="AKH82085">
        <property type="protein sequence ID" value="AKH82085"/>
        <property type="gene ID" value="AA958_07415"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_07415"/>
    <dbReference type="OrthoDB" id="854213at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="178"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="249"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="277"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="317"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="358"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="387"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="443"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="494"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH82085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="509" mass="50938" checksum="278241027CCE7BE2" modified="2015-07-22" version="1">MRARWAIASSVADQGVAALTNIAVLVVAARESSAEGFAVFSLVYMTFTVVLGVQSSFVGQALVLERDGGKNGRAGAGGSGVGPEGAGATQDGPVIPSWAEPDPDTPRPPPTGVASACRSAVTFSALSSTAVGGTAALLLALVPGELAHGLAMLGVVLPVVLLHDVLRYCFAALRLPHHALLADLLRLVVAVPALVLQPDGSSPARLIAVWGASALPALLLCLALAGYRLRGARGDWRRYLRRGHLGRRFVVEFAVGNGATQLSVIGLGLVASQLAVGALRGATTLYGPMNVLYNSATSFGPPVMNRIPNLRGKLRSAAALAVLLAGTAAAWTTVLVLLPDSAGRQLLGDTWASTSSLLPATGSQYAGIALGTSALLTLRVLRPESTLPIQVVFSLLSVGCMLTGYAAGGVLGAAWGLCAGSALKAAALWLRVAAVSRSLAATGPGGAGGSGDAGGSGGPGGTAGSGGGAGSAHAGGHAPVGGTVTPGAVPAARPRSHRKPRSRPGRLRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0K0</accession>
    <name>A0A0F7N0K0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Urease accessory protein UreF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ureF</name>
        <name evidence="4" type="ORF">AA958_00325</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UreF family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH80869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014235.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_00325"/>
    <dbReference type="EnsemblBacteria" id="AKH80869">
        <property type="protein sequence ID" value="AKH80869"/>
        <property type="gene ID" value="AA958_00325"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_00325"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.77"/>
    <dbReference type="OrthoDB" id="1942614at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01385">
        <property type="entry name" value="UreF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002639">
        <property type="entry name" value="UreF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038277">
        <property type="entry name" value="UreF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01730">
        <property type="entry name" value="UreF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009467">
        <property type="entry name" value="Ureas_acces_UreF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 3" id="KW-0996">Nickel insertion</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH80869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="233" mass="23018" checksum="17DB867DD8E02C12" modified="2015-07-22" version="1">MPPPPAIRAALLVLADGRFPAGGHAHSGGAEEAVAAGRITDAVGLAAYCRGRLHTAGLTSAALAAAACAGADPLRLDEAADARTPSPALRATARKLGRQLLRAARAAWPNAELDALAEARPRGVHQPVVLGLAARAAGLGPGDAAHAAAYEAVSGPATATVRLLGLDPFEATAVLARLAPELDDVAARATAAGVRAAAAGRADVGALLPAAGAPLLDIAAEEHAVRAARLFAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0M4</accession>
    <name>A0A0F7N0M4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_08000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015535.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH82185">
        <property type="protein sequence ID" value="AKH82185"/>
        <property type="gene ID" value="AA958_08000"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_08000"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1687"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="68" mass="7529" checksum="2F1A9C80C50BF221" modified="2015-07-22" version="1">MSGSDWIWGGLLALGAVVEVVALWTPKKGDTLSERTRAWFRVRTPVGKAVFVAAWVGFAGWFLVHIAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N135</accession>
    <name>A0A0F7N135_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sporulation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_01815</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CbxX/CfxQ family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014477.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_01815"/>
    <dbReference type="EnsemblBacteria" id="AKH81113">
        <property type="protein sequence ID" value="AKH81113"/>
        <property type="gene ID" value="AA958_01815"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_01815"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.395"/>
    <dbReference type="OrthoDB" id="464195at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041627">
        <property type="entry name" value="AAA_lid_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039448">
        <property type="entry name" value="Beta_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006633">
        <property type="entry name" value="Carb-bd_sugar_hydrolysis-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000641">
        <property type="entry name" value="CbxX/CfxQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17866">
        <property type="entry name" value="AAA_lid_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13229">
        <property type="entry name" value="Beta_helix"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00819">
        <property type="entry name" value="CBXCFQXSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00722">
        <property type="entry name" value="CASH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CASH" evidence="4">
        <location>
            <begin position="44"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="CASH" evidence="4">
        <location>
            <begin position="316"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="3">
        <location>
            <begin position="594"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="477"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH81113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="817" mass="85248" checksum="05D40C1C03285D7D" modified="2015-07-22" version="1">MAQGSVQVTHTGSVRTGRWRRRTGEYGSLAAALEAAGDGDVLSLAPGTYRENVVLERAVTLRGPGGAVGSVRIAPADGVALTVRASAVVEGLHVEGEDAAVPAVLVESGRPELTGLRVVTRSAAGIEVRGDARPTVRRCAVDNPVGTGVTFADGSGGALENCEVLAAGRSGIAVRGGSSAHLSQCRIHHAGGAGLLLTGEGSTVEAVGCEVYEIKGAGVQLTSRASGELTDCTVHRTSGDGISLDTEAVVKLTDCEVHDVPENAVDLRSRAQAKLARVTVRRFGRNGLSVWDAGTRAEAAQCEVHDSTGDYPAVWVSDGAAASFTSCRVHDVPDALVVLDRGSSVEATDTDLAQIRGTAVSVSDGATVALEQCRIRDAATGAWFRDHGSGGNVRDTTVDSVASGIIVTKGADPAVEGCTITSPTEAGVFVSAAGRGSFTGCRVTGSLGYGFHVIDGCRSALTRCRTERCARGGYEFADAGPSAPEGSGGGPVVEDCTSDESAEMASARPTVPAARTEPEPDGLLGAFAPQRAGAAGAVRPAAEAQPAARPAREVLAELDALVGLENVKREVRALTDMIEVGRRRRQAGLKAASVRRHLVFTGSPGTGKTTVARMYGEILSSLGVLERGHLVEVSRVDLVGEHIGSTAIRTQQAFERAHGGVLFIDEAYALAPEDSGRDFGREAIDTLVKLMEDHRESVVVIAAGYTTEMERFLAVNPGVASRFSRTITFGDYTAEELLRIVTQQAEEHEYRLGDGTDEALLKYFTVIPKGAGFGNGRTARQTFEAMVERHAGRVAQLPDPTTDELTLLYPDDIPVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N144</accession>
    <name>A0A0F7N144_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminotransferase</fullName>
            <ecNumber evidence="1">2.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_05400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.-" evidence="1"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015080.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_05400"/>
    <dbReference type="EnsemblBacteria" id="AKH81726">
        <property type="protein sequence ID" value="AKH81726"/>
        <property type="gene ID" value="AA958_05400"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_05400"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1132"/>
    <dbReference type="OrthoDB" id="1248286at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="2">
        <location>
            <begin position="30"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH81726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="361" mass="37579" checksum="711C6DB2A5B12999" modified="2015-07-22" version="1">MRTDPSPPPAPHDLRHHGDAELRDAAPGLTDLAVNVRAGTPPAWLKARLAASLDRLAAYPDGRAARAAVAARHRVPADRVLLTAGAAEAFVLLARALRPAVRRAVVVHPQFTEPEAALRDAGYAVDRVLLRAEDGFGLPPRAVPEDADLVVVGNPTNPTSVLHQAAALAALARPGRVLVVDEAFMDAVPGERESLAGRTDVPGLVVLRSLTKTWGLAGLRVGYVLGDPATVAALARAQPLWPVSTPALIAAEAVCAPRALAEAEAAARAVGADRAYLLARLGEFAEVTTAGTAAAPFVLVHVAGPDGAAAGLAVRERLRGLGFAVRRGDTFPGLGPGWLRLAVRDRRTTDRFAEALAKALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N178</accession>
    <name>A0A0F7N178_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_05660</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015125.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_05660"/>
    <dbReference type="EnsemblBacteria" id="AKH81771">
        <property type="protein sequence ID" value="AKH81771"/>
        <property type="gene ID" value="AA958_05660"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_05660"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1185"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="132"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH81771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="354" mass="37873" checksum="51496630BB84D6FD" modified="2015-07-22" version="1">MRALRGHYAYWAGGLFLIAVTAVDLSTSRGSSLAALFAVVPALVAVNGTRRAIFVSGAVAMVMGGLLSWWNFHAFDLDFAARVLGILGAIGIGLLVHRERLVRERQLGSVTRVANVVQQALLPAPPARAGPLDVAHSYQSAADEAMIGGDFYKVLCTRWGVRVVIGDVRGHGLGVVRTTGMVIAAFREAAHEEPELNRIAARMDRSLARDGGPEDFATVLLLTISAEGLCRARNHGHPPPLLRSAAGRVREADLHGGPPLGLGLARSLQDVEETTMALAEGAELLLATDGVLEARSAAGEFFPLAERYARAPRERPPADVLAALRHDLADWAPDLHDDSALVLLRYAPRRIRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N180</accession>
    <name>A0A0F7N180_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH luxR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_08925</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015677.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH82330">
        <property type="protein sequence ID" value="AKH82330"/>
        <property type="gene ID" value="AA958_08925"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_08925"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1879"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="683"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="639"/>
            <end position="661"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH82330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="754" mass="79272" checksum="4E91AAA31FC14636" modified="2015-07-22" version="1">MSILVELTRSTAPGEWDADLAPEGPPGLHDTLIGREQEIADVRARLAAPGCRLLTVTGLAGVGKSALVRAALADRTGTDPSAAVSVDLAAAADADGVWTRVAAALSRPPDGDAREAAWTALADRAADRELLLVLDNGDLAARAVAGDIAVLLRRIPRLCVVFTSRVALDIHAERIFPLGPLATGAAGAAGPSAASDAARLFVARLQPHYRWAVTSAADRDGIAEICALLEGVPLAVEEAARAVGALSPRRMLQRIRDGEQLYSRRLVDVPSRHGSMDAALSWGDAALTAGELQLLRRLSVCEGAFDLAVAQQVAGLTWAQTVQGLDALVRKSLLHSVKREGAEPEFRMFRATRQHYRARLAADPADLAATRARHAAHTLEFALQARQGLRLPKERAYWLELVAERTPDLFAIARLNQETGEHAAAARMLLALEEAWTVHDLLGTAGALLDGSLAALTGAEGAQATEAAARWALTEGDWARAEAYIERLGRSLDAAARAAALRAELMLGRGDAVGALQQAEFALAGKRAPGGTVAAARVLRTLAAARAAVGRRQPEEPLVKAARGLLELGEPRQAALTLAALAVAQRGHARARAGAGEAVELLLAHAAPVRDVRAVLLAAAGTVPAGGEAYRRLGALADRIPERGDDPPQGAPEPAAPDGHGGMLLAARAALAEAAREEAEAAPAGGLERLTHRQLQVAELVAEGMTNRQIARALELSEWTVVNHLRQVMQRLDCPSRVHVARIVQGRATARLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N186</accession>
    <name>A0A0F7N186_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Arabinose isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_02180</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014537.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_02180"/>
    <dbReference type="EnsemblBacteria" id="AKH81173">
        <property type="protein sequence ID" value="AKH81173"/>
        <property type="gene ID" value="AA958_02180"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_02180"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.469"/>
    <dbReference type="OrthoDB" id="507566at2"/>
    <dbReference type="UniPathway" id="UPA00575"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008733">
        <property type="term" value="F:L-arabinose isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019568">
        <property type="term" value="P:arabinose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038583">
        <property type="entry name" value="AraA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004216">
        <property type="entry name" value="Fuc/Ara_isomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009015">
        <property type="entry name" value="Fucose_isomerase_N/cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003762">
        <property type="entry name" value="Lara_isomerase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38464">
        <property type="entry name" value="PTHR38464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02610">
        <property type="entry name" value="Arabinose_Isome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50443">
        <property type="entry name" value="SSF50443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53743">
        <property type="entry name" value="SSF53743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0054">Arabinose catabolism</keyword>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH81173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="481" mass="51070" checksum="F0FAD08D1E13759C" modified="2015-07-22" version="1">MTTARIPATARRPRVGLVAGGLGAYWPQFPDLLPQLRRSAARVAERMAGFDAEVVDAGFISDTPGGAAAAEKLRAADCDLIVGFLTTYMTATMLVPVAQRSGAPVLLINLQPTEAMDHASFDTGQWLAYCGACPLPEMANAFERCGVPFRSVSGHLEDERAWARIGRWIRAAGVRAVLRGGRHGLMGHLYPGMYDVSTDLTMVPANLGGHVEVLEFDDLRVRAAKAGDAEVAAKLAETREVFDLDATVDPDDLAWAARVSVGLDRLAADFDLDSLAYYHRGLDGETHERLGAGMILGASLLTARGIPAAGEYELRTSLAMLVADRFGAGGSFTEMQALNFRDGVVEMGHDGPGHLAISEGRPLLRGLGVYHGKRGWGVSVEFDVRHGPVTAVGLGQTRDGRYRLIASTGTVTPGPLLAIGNTTSRVDFGRDPGEWCDEWSASGVGHHWALATGHLLPELRALADLAGLDLVEVAGSGEGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N1C9</accession>
    <name>A0A0F7N1C9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_02295</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014558.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_02295"/>
    <dbReference type="EnsemblBacteria" id="AKH81194">
        <property type="protein sequence ID" value="AKH81194"/>
        <property type="gene ID" value="AA958_02295"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_02295"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.492"/>
    <dbReference type="OrthoDB" id="1231841at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023375">
        <property type="entry name" value="ADC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018644">
        <property type="entry name" value="DUF2071"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39186">
        <property type="entry name" value="PTHR39186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09844">
        <property type="entry name" value="DUF2071"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160104">
        <property type="entry name" value="SSF160104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH81194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="245" mass="27086" checksum="753543D2EFF0FE04" modified="2015-07-22" version="1">MQKPEPVTPDAPHALRFPLLTQQWLDLTFVHWAVEPDAVARLLPRGTAPDTHDGVAYAGLVAFRMHRVGWLRLPAVPYLGSFPETNVRLYSVDGRGRRGVVFRSLDAARLVPVVLGRLGFGLPYVWSRMAVRRAGDTVVYTSSRRRPGPRGAYSRLTVRPGARIGEPSALEHFLTARWGLHTAFFGGTAYLPNEHPRWPLHRAELVRCEENLVAAAGLPAPAGDPVSVLYSPGVQVHFGRPRRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N210</accession>
    <name>A0A0F7N210_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_10790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH82630">
        <property type="protein sequence ID" value="AKH82630"/>
        <property type="gene ID" value="AA958_10790"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_10790"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2269"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="157" mass="16809" checksum="3CBB59FAED4F49CF" modified="2015-07-22" version="1">MRSSQVETAAAGASMSASLSEEVSARQMTLPEPDFVGQTRTSPWPHGRNTPSTSSSRANDQRTGAAEPMGKLMWTAYGSDDRYGSLDGTGTLFSGDSTSRSSSSRSTTVRMVWHLSCRTSRRSDGPAGGERAKRGRSYATSADFLPSFDKSLKAERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N265</accession>
    <name>A0A0F7N265_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_11115</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016028.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH82690">
        <property type="protein sequence ID" value="AKH82690"/>
        <property type="gene ID" value="AA958_11115"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_11115"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2341"/>
    <dbReference type="OrthoDB" id="498436at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="149"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="227"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="289"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="316"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="351"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="381"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="408"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH82690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="431" mass="43343" checksum="83ECB8B05A8C5E81" modified="2015-07-22" version="1">MTRPRVPRAYRPVLAHPRLRRLLPAFVASDFGGGMSMVAVAWLALLIAPDGREGLLVGAALAAYALPGAAGVLLLGRWLRKLPARRLLIANCALRGTLLGCVPLAWGLGVLDPVTYVVLLGSSSVLTAWGSAGKFTLVGELLPERHRLAANALLGASMSTSIVAGPAAAGFLATAVSPAWIIGLDALTYAILAVQTARLGPGGEERPNAAAGPAGRGLRLLAGERELLAILALTWLFFALYGPVEVALPLYVTGALDGDAGLLGLFWTAFGVGAVAGGLTVGALRRLPLWPVTLGIVAGWGATLLLPYGLGAGTAAAMACFALGGAVYGPYPALSFTLFQNRTPQGRLTTVLAARGAVLLTSTPVGAALGGPLVTAFGARAVLAGSGAATVGVAAVGTGVWLATRGARPVAEGDGGPDDDGARGDGARAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2B2</accession>
    <name>A0A0F7N2B2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Anhydrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_01170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014372.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_01170"/>
    <dbReference type="EnsemblBacteria" id="AKH81007">
        <property type="protein sequence ID" value="AKH81007"/>
        <property type="gene ID" value="AA958_01170"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_01170"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.258"/>
    <dbReference type="OrthoDB" id="1242595at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14602">
        <property type="entry name" value="Hexapep_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH81007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="178" mass="17918" checksum="0FB920FDE8BCA5B0" modified="2015-07-22" version="1">MSGRPEPLIAAVGGREPAVDPKAYVAATAVVVGDVTLGAEAGVWYNAVLRGDCESISLGAGSNVQDNCTVHADPGFPVVIGERVTVGHNAVVHGCTVGDDVLVGMGATLLNGAVIGSGSLVAAQALVPQGMEVPPGSLVAGVPAKVKRPLTDEEREHIRLNGAGYVALTQVHRESLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2C7</accession>
    <name>A0A0F7N2C7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 4">Imidazolonepropionase</fullName>
            <ecNumber evidence="1 4">3.5.2.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Imidazolone-5-propionate hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">hutI</name>
        <name evidence="6" type="ORF">AA958_11535</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the hydrolytic cleavage of the carbon-nitrogen bond in imidazolone-5-propanoate to yield N-formimidoyl-L-glutamate. It is the third step in the universal histidine degradation pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>4-imidazolone-5-propanoate + H2O = N-formimidoyl-L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:23660"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58928"/>
            <dbReference type="ChEBI" id="CHEBI:77893"/>
            <dbReference type="EC" id="3.5.2.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="4">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
        <text evidence="4">Binds 1 zinc or iron ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid degradation; L-histidine degradation into L-glutamate; N-formimidoyl-L-glutamate from L-histidine: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallo-dependent hydrolases superfamily. HutI family.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.7" evidence="1 4"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016096.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_11535"/>
    <dbReference type="EnsemblBacteria" id="AKH82760">
        <property type="protein sequence ID" value="AKH82760"/>
        <property type="gene ID" value="AA958_11535"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_11535"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2427"/>
    <dbReference type="OrthoDB" id="785930at2"/>
    <dbReference type="UniPathway" id="UPA00379">
        <property type="reaction ID" value="UER00551"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050480">
        <property type="term" value="F:imidazolonepropionase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019556">
        <property type="term" value="P:histidine catabolic process to glutamate and formamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019557">
        <property type="term" value="P:histidine catabolic process to glutamate and formate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00372">
        <property type="entry name" value="HutI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005920">
        <property type="entry name" value="HutI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42752">
        <property type="entry name" value="PTHR42752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01224">
        <property type="entry name" value="hutI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0369">Histidine metabolism</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="5">
        <location>
            <begin position="62"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="70"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>4-imidazolone-5-propanoate</name>
            <dbReference type="ChEBI" id="CHEBI:77893"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>4-imidazolone-5-propanoate</name>
            <dbReference type="ChEBI" id="CHEBI:77893"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="227"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>4-imidazolone-5-propanoate</name>
            <dbReference type="ChEBI" id="CHEBI:77893"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="301"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>N-formimidoyl-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58928"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>N-formimidoyl-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58928"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>4-imidazolone-5-propanoate</name>
            <dbReference type="ChEBI" id="CHEBI:77893"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH82760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="393" mass="40808" checksum="199077C8A76A5596" modified="2015-07-22" version="1">MTATAIVNIGSLVTNDPALGDGPLGLLQDAAVVFDGDRVAWVGAADAVQAADTAYDAAGRALLPGFVDSHSHLVFAGDRTREFAARMSGRPYTAGGIRTTVAATRAATDEELAANLARFVREMLRQGTTTLETKSGYGLTAADEARGLRVAAEQVEEVTYLGAHVVAPEYADDPGAYVDLVTGEMLDACAPYARWIDVFCEKGAFDGDQARAILAAGKVRGLTPRVHANQLSYGPGVQLAVELEAASADHLTHLTDADVAALASGVTVATFLPGCEFSTRAVYPDVRRVLDAGATVALSTDCNPGSSFTSSMPFCVAVAVREMGMTPDEAVWSATAGGAAALRRTDVGRLAPGARADAALLDAPSHVHLAYRPGVPLVAEVWRRGERVPAGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2D0</accession>
    <name>A0A0F7N2D0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_11630</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016111.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_11630"/>
    <dbReference type="EnsemblBacteria" id="AKH82775">
        <property type="protein sequence ID" value="AKH82775"/>
        <property type="gene ID" value="AA958_11630"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_11630"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2446"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519176" evidence="2">
        <location>
            <begin position="20"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH82775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="194" mass="19724" checksum="BC11E2EB80A473E4" modified="2015-07-22" version="1">MARGTVTLARAAVVVRAGAAPLWWLGIAAAAAGAWQDGLTGQWIGLYAGAALFLAVAPAVWAVRRGRLLTQARKAQRAGRGAVLQDRAVTVRTWRRARRWWLAAAFAVAAGSAAAMPVAGGLALAGAGAGLRAKAAWLGRWEREQEALLWLPVDAVTARGAGTGGSGAAYLRTGIAAGDALPGGGVRRGSPATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2D9</accession>
    <name>A0A0F7N2D9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_04330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014899.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_04330"/>
    <dbReference type="EnsemblBacteria" id="AKH81544">
        <property type="protein sequence ID" value="AKH81544"/>
        <property type="gene ID" value="AA958_04330"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_04330"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.910"/>
    <dbReference type="OrthoDB" id="1746871at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519705" evidence="2">
        <location>
            <begin position="26"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH81544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="453" mass="48467" checksum="93DE8FCE6D17E712" modified="2015-07-22" version="1">MSRRTSRSHTALGLVALTGALLAAACSGPGDDSGPEQTETTDAVAGAPSCGDEPITMQGYFETGFPMPKALTDEFTKQYPNVRWNIREDQFAVITQNAPRLLAENPPDLMRLPQLSELVKDDLLKDLDGYAKAFGWDKWPEGQLEQLRLGPGGRPRGEGPLYGMGLNFSMTGVFYNEKLAERIGMTSPPTSLAEFDGALEKAEKAGVTPIVQFNGGATGGFAFPLQNLMAAYGDPGPINEWIFQKEGATIDTPPNRDAARHLEKWVEAGYFDPDGNAMDYAKMMSKFIAGDGLFMFNGDWESGNLDKQMKGDAGFFLFPPAAEGGKPATMSAPLTFGIGKNAKNADCAAFFLDWVATDDKARAIAVDVGGSHPMGLPDASMPETEKGTVTAETLAAGAEIAAADGAMDFIANATGSIYAESWTPQLQKLAAGEVTSRQLLEAVQSDYERQVED</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2M6</accession>
    <name>A0A0F7N2M6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphotyrosine protein phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_08460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015609.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_08460"/>
    <dbReference type="EnsemblBacteria" id="AKH82261">
        <property type="protein sequence ID" value="AKH82261"/>
        <property type="gene ID" value="AA958_08460"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_08460"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1786"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023485">
        <property type="entry name" value="Ptyr_pPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036196">
        <property type="entry name" value="Ptyr_pPase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01451">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00226">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52788">
        <property type="entry name" value="SSF52788"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LMWPc" evidence="1">
        <location>
            <begin position="88"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="220" mass="23683" checksum="1F9FF84C208FCF93" modified="2015-07-22" version="1">MSDPGGQVRPDPRAGHRLALHTAAKRLRTEFQGVFGEQTIERFLYGAYGDIAVRGAPPDDLPRLTERYARRRLHALARVEEVSGDGRPVVLFLCAHNAGRSLMAMGLMARLAGNRAVAWSAGSAPGASANAAAVAVMGERGIDISGEFPTAWTDEVVRAADVIVTMGCGDASPVFPGKRYVDWPQADPHGWAVAEVRPLRDEIEQRVRKLLADLGIPPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2U2</accession>
    <name>A0A0F7N2U2_9ACTN</name>
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        <submittedName>
            <fullName evidence="4">DNA polymerase III subunit epsilon</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_05195</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015048.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_05195"/>
    <dbReference type="EnsemblBacteria" id="AKH81693">
        <property type="protein sequence ID" value="AKH81693"/>
        <property type="gene ID" value="AA958_05195"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_05195"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1091"/>
    <dbReference type="OrthoDB" id="1985371at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
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    </dbReference>
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        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR006054">
        <property type="entry name" value="DnaQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Exonuclease_RNaseT/DNA_pol3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="SSF52113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00573">
        <property type="entry name" value="dnaq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="3">
        <location>
            <begin position="51"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="278"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH81693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="370" mass="39887" checksum="77789D9D7F9A1D55" modified="2015-07-22" version="1">MLEDRATPLSPRQVARQQPLPGAGPAAPQPALPLPPPAAPADGWPADYPEAYAVVDVETTGLRSDDRIVSAAVYRLDAHGAVEDSWYTLVNPERDPGPVWIHGLTREMLADAPLFPEIAEEFTARLEDRVLVAHNAVFDWMMIAREYARAGLTAPVRRRLCTIALARQLRLPLPNARLASLAEHFGVAQRKAHDAEDDARVLAEIFRPSLRQAAEAGARLPLLACQPLTEWAEQAPAGGTGGTRSPGGHGAYQWRTWRPNRRLPASPYPNPGRYVRGGRLKQGMRVAFSGDTSVDRSLLEDRAVEAGLHVAGSVSRYTSLLVTNDPGAPTSKVTRAAAHGTPVIDEAAFLHLMRDVEPAEAPPGEEGGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2Y1</accession>
    <name>A0A0F7N2Y1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">XRE family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_08985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015688.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_08985"/>
    <dbReference type="EnsemblBacteria" id="AKH82341">
        <property type="protein sequence ID" value="AKH82341"/>
        <property type="gene ID" value="AA958_08985"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_08985"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1892"/>
    <dbReference type="OrthoDB" id="1508493at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="20"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="284" mass="31062" checksum="49F96E9AE49C21EE" modified="2015-07-22" version="1">MPMSPSSSAQEARAALAARLRELRLDAGITSKELAARCGWSVAKPSRIENAHTAPSDADIRAWCTACHAEGQAPDLIAANRQADQMYVQWRRLQRTGLRRLQEAAAPLYERTRAFRTYASNVVPGYLQTPAYATALMGTIASFRGTPDDVSEAVAARMRRSRVIREGDHRFAVLVEEHVLNHRLGDAGVMSGQLGNLLACMTLPAVSLGIVPTAMPRETVMWPLEAFTIFDDSQVNIELLAARVRVTAPSEIELYEQAFAKFTQLAVYGAEARALILKAIEALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2Z9</accession>
    <name>A0A0F7N2Z9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_09185</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the bacterial solute-binding protein 9 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015717.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_09185"/>
    <dbReference type="EnsemblBacteria" id="AKH82371">
        <property type="protein sequence ID" value="AKH82371"/>
        <property type="gene ID" value="AA958_09185"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_09185"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1938"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030001">
        <property type="term" value="P:metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006128">
        <property type="entry name" value="Lipoprotein_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006127">
        <property type="entry name" value="ZnuA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01297">
        <property type="entry name" value="ZnuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00690">
        <property type="entry name" value="ADHESNFAMILY"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <keyword evidence="1 3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002518997" evidence="5">
        <location>
            <begin position="20"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="130"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH82371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="333" mass="35288" checksum="8ECABF3CD5195003" modified="2015-07-22" version="1">MSVMRASRRSISGLTPAAAAALSTAALLALSACGDGASGTTTEDGRLRVTASFYPMQFLAEEIGGENAEVSTLTKPGTEPHDLELSPRQTGDLADAGLIVYLKDMQPAVDEAIEQSGAEHVVEASEFTSLEKHGEEDGDGGHAEEEADGGHEGHDHGGEEGPDPHIWLDPVRYAEVAEGVGEAMAEADPEHAKAYEKNAAELADRLRQLDGEFAAGLENRRTDTFITTHAAFGYIADRYGLVQESIKGLSPESEPSAARMQQLQDIAADDGVTTVFFETLVSDKTARTLAGDLGLETDVLDPIEGVTDKSRGDDYFEIMEANLGALQKALGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3C4</accession>
    <name>A0A0F7N3C4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_10195</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH82536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="66" mass="7740" checksum="5B7C1D9CF6A8A07D" modified="2015-07-22" version="1">MTDSLWSYKEIAAHIGVQTETVRSYRKHGMLPAPDVVEHGKPYWYPDTVRAWVAQRPSSRTRRGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3F9</accession>
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
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        </location>
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    </feature>
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    </evidence>
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    </evidence>
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            <dbReference type="EMBL" id="AKH83215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="121" mass="12017" checksum="0EAA056FD5574E43" modified="2015-07-22" version="1">MWSALACFALCAVFAAALALGQAVHSRHRAGGAADLAALAAADRALLGEAAACAAARRVTAAQGARLLRCAVAGEVADVVASARTGRFTAEVRSRAGPPAPAGLAAGLRPVPQPVPRPGLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3N7</accession>
    <name>A0A0F7N3N7_9ACTN</name>
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                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </reference>
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            <dbReference type="EMBL" id="AKH81462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="117" mass="10639" checksum="3B4FE079AC0A846D" modified="2015-07-22" version="1">MAPADPDPAGGTVPPDVAVPADSAAGGGGSAARGRFGRTGPPVGAGPAARAAVPEPPAGPTGRCGSAPGRGRTGRTGSALSGFALSRGLAAGGESGDGGAAGVCSASVLNSPLTPLL</sequence>
</entry>
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    <accession>A0A0F7N3V9</accession>
    <name>A0A0F7N3V9_9ACTN</name>
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    <reference evidence="2 3" key="1">
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                <person name="Albersmeier A."/>
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                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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    </dbReference>
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            <end position="87"/>
        </location>
    </feature>
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            <dbReference type="EMBL" id="AKH82711.1"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="204" mass="22347" checksum="F9DBAA1091B03ACF" modified="2015-07-22" version="1">MTTTRTRPEGGPERNEPAAGTATGDERTGGTAAGPSHEPAPGSPYDAACDAARGRSPARRPPRAKPRRPRGRTAPPNRRGTRRPGRPPARHRAGELRPHEWFAERLMLALSGQRPMHWLLGHTTGRAYDQLAAFADDLPLRDGPRPELRACGYCRPAPDAIEGFARIAVGDRLRALAFRLELGPDHRWRCAAVEMAPSPERDRA</sequence>
</entry>
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    <accession>A0A0F7N3Z7</accession>
    <name>A0A0F7N3Z7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="1 2">
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        <lineage>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH83365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="109" mass="12407" checksum="BA44CD6799E68EB8" modified="2015-07-22" version="1">MSQRTPPEPRWFHCECHVDEHRLGTFDAYSTGEALRWLTASLMMIAISMDEEPYRQARAWIDHGQAETTRELSKGQAHTLTLKQGTTHATWTVTPVPYLPPPKQADTGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N468</accession>
    <name>A0A0F7N468_9ACTN</name>
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        <submittedName>
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    <organism evidence="2 3">
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        <lineage>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82178.1"/>
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    </dbReference>
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    <dbReference type="STRING" id="444103.AA958_07965"/>
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    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_07965"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1680"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="221" mass="23663" checksum="0EA435D42F58664F" modified="2015-07-22" version="1">MDVYEAVDTRRAVRAFGDEPVPVEVLQRVLSAAARAPSSGNLQPWHLYVVTGEPLAGLKKRATARALAGDPGDEREYPMYPADLGPPYRDRFTAAAAQRYAALGIERDDPGRPRKIAALNAGAFGAPVVLFCYLDRAMGPGQWADAGMYLQTVMLLLRAEGLHSCPQVMWTMYRRTVAEAVGAGDGLVLLCGVAVGHAKAGVPPLRTDRADPAETVTFVGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4D3</accession>
    <name>A0A0F7N4D3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Copper oxidase</fullName>
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    </protein>
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            <authorList>
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
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                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6 7">CNQ-509</strain>
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    <sequence length="180" mass="18828" checksum="E46E8E2CC7941920" modified="2015-07-22" version="1">MSPRPPYARSAPPRRTLAAALAVALVLAFAGFSAWRYAAAATRDDLDFGRERDRVLAAGQEHIGTLNSIDAADPDAGLARWEDATTGPLHEDLRRSRAASAGAVDRAGVTVRATVTEAAVTELDPRAGTAKALATVRVETSGGADGERTDRKRFEAGLERTGDGWKIASLTAITVEGSGS</sequence>
</entry>
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    <accession>A0A0F7N520</accession>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AKH82503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="1257" mass="126706" checksum="7BC803B5D2A04956" modified="2015-07-22" version="1">MTGFVLLRARAHRLLLAAALLAVLLTTAVLATLAAFSGTVGDAALRRTLAGDAAADAALTLEVPYLTGADREAAGKAVEDNAPAAFAGLPVRVQSLDRSGPYELPRRLQPPAARAGEDPDLTHLGALERSEVALTAGRWPGAAATPPAAAGASDARDGGAVEVAVPQIAADRLGLAPGDTLALAGRSDDDPPLPVEITGVYRPRDREAPYWLADELRGKGVQQGGYTTYGPLLADPGSFASGRVPQAAGAWVLRGDFGEMTAGRADALRASVKKASGALADEPVFDGRAVATTRLPQLLDGTERALLVSRSTLLIVALQLVLLAGYALMLVARLLGAERRGETDLLRARGGSRQRIGVLTAAESLLLALPAAIAAPLLAGPLIRLLSARGPLERAGLTPDSAAGRGTWLVAAACALGCAAAVVAPTLLRGGGADGVPSAGRTVRAKPLPAPLRAGADGALLVVAGVAYWQLDRQTSGSGALSGDRSGTLGIDPVLVAAPALALLAGTVLTLRLLPPVARLAERRAAAGRGLPSALAGWQLSRRPLRGAGPVLLLVLAVAIGMLALAQGASWDRSQRDQADFHAGTDVRVLTSRLPELGQGGMMERVPGVTAAAPAARWGMSLSGGGSAEVLALDTARAAEGLRLRPDLADGAEGAELLRKLAPGGPVGKQESAPPGPEEKRESAAGAEGAGSGAYATGGTSAADSTGATGRTRHPAAGAERPAGGPPPDARRAATAPADTAAHPAARAERAVGDPDPPDRPASPDRAVPAAARAGGAGAAAPTASQAPAERTRAGGLELPGLPGEVRVVARLDADATARGRAAVTVLVEDRYGAAYELPAGDLPADGRTHTLTADVAAAAAAPDGRPAGPLRLTGLRLVHPQPRDGGERRLDVARIEVAKPLGEEDPAAGAREVPLPDGFRWHARAVSEPEALHDETPAAVADRPRATGDSALSLSYGTGDQFYDTWTGPPLVTLTVTAARGATWPLTALATDEMLKSTGAKVGDTISVPVPGGSLSAKITGSVQELPTTGPGSPAAAAEPSRARFGGALLIDLPTANGALTQRGLATLLPSEWWLTTRPGETDTAVAALRDRADTDPGNVLVRDELAGELGGDPLGAGPQAALAATAAAAAVLAALGFAVSAAASVRERTREFAVLRALGAPQRQLARTFAAEQGVLITLALAAGMLLGWALARSVIPLITLTGRAAQPVPPVVVELPAGSVAGLLAAVAAVPVLVTVLVALRRGDPATALRLGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5J1</accession>
    <name>A0A0F7N5J1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FAD-linked oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_11035</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016012.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH82674">
        <property type="protein sequence ID" value="AKH82674"/>
        <property type="gene ID" value="AA958_11035"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_11035"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2324"/>
    <dbReference type="OrthoDB" id="330793at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519282" evidence="2">
        <location>
            <begin position="36"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="3">
        <location>
            <begin position="62"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH82674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="544" mass="59091" checksum="97A250852F3A9FFB" modified="2015-07-22" version="1">MDNVSRRKVLLSGAAVGSAAALGGGRLAAATPAGAAAGVPASTITPADARYPDFVSGSNGRWRADPEAIRVATATEQVVAAVEEAVRAGKRVSVRSGGHCYEAFVYHSDAQVVIDLSAMNDISYDQKRRAFVIGPGCTLMEVYMELYRVWGVTIPGGSCSSVGAGGHIQGGGFGLLSRAFGLTVDYIHAVEVVVVDASGKARAIVASSDENDPHHDLWWAHTGGGGGNFGIVTRYFLRAPGTERLAPEKQLPQPPGEVYVHQQSWPWSNIDEDRFRTLLRNYSGFYEEYSAPRNPYAGMFSMLVCSTKASGSISMTTQIDATQPDAARKLDDFLAEIGGHMGDAQPTTLSTNEMRAMPDLFAPQARPWLVATRQLGGSGWGGRGDYKSAYLRRAFPDEQISAMYQNLTETDQRSALVSIDSYGAQVNAVGTDATAAPQRDSIIKLQYQAYWSEQSEEAAKLGWIRNMYRDVYADTGGVPVPNEVNDGCYINYPDIDLGDPQWNTSDTPWHDLYYKQAYVRLQRVKAAYDPGNVFRHAQSVRLPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5Q6</accession>
    <name>A0A0F7N5Q6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_18855</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017212.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_18855"/>
    <dbReference type="EnsemblBacteria" id="AKH83915">
        <property type="protein sequence ID" value="AKH83915"/>
        <property type="gene ID" value="AA958_18855"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_18855"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3958"/>
    <dbReference type="OrthoDB" id="1370895at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005523">
        <property type="entry name" value="DUF317"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03771">
        <property type="entry name" value="SPDY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SPDY" evidence="2">
        <location>
            <begin position="54"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="SPDY" evidence="2">
        <location>
            <begin position="137"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH83915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="259" mass="28137" checksum="94838926C8B00BD8" modified="2015-07-22" version="1">MTTPPPPGSVEVDFISPRHLAGGGDPAWVTVPLHRACGWSHGNDPLMPRVVLSSPDHQALLRLEPAPDNRWWTLIHAPEADRRPAWFVSFGARTPVELIAAVTDALTDPSAQANTPSDPYEPLLQAGWTRNASGIRSPDSTADITRSETADSPGAWLVTVKLGAHQRVWQARFGEHTPPHLIGAFTTALADPAPLLRTGYRGTLPIHDPKLITRRSQAVRADLAVAALEERVRTLAARHTRPPASPNPSHPPANNRRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5T5</accession>
    <name>A0A0F7N5T5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_11560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016100.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_11560"/>
    <dbReference type="EnsemblBacteria" id="AKH82764">
        <property type="protein sequence ID" value="AKH82764"/>
        <property type="gene ID" value="AA958_11560"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_11560"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2432"/>
    <dbReference type="OrthoDB" id="1356861at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH82764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="268" mass="28020" checksum="E80A0602C8F6DA78" modified="2015-07-22" version="1">MPETARTDHVALVTGANHGIGAAVAKALAARGVAVLCTYLRESGEEATDDYRRARSAGGEAVVEEIREAGGRAASLEADLSDPAAPAALFDAAEHHLGAVDILINNASGWIQDSFAPRPADRFGRPLRAVTAETWSRQFAVDAMAPALLISELSRRHRARGATWGRIVGLTSGGDLGFPGEVSYGAAKAAQTDYTLSAAAELADLGITANVVHPPVTDTGWITDEVREFVASSGTHFHVATPDEVARAIVFLTSDDAALVTGNIITLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5U7</accession>
    <name>A0A0F7N5U7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_19050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017240.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH83945">
        <property type="protein sequence ID" value="AKH83945"/>
        <property type="gene ID" value="AA958_19050"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_19050"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3999"/>
    <dbReference type="OrthoDB" id="1903052at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH83945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="100" mass="11344" checksum="92F80EEB81EB0B96" modified="2015-07-22" version="1">MSPTRPEAPCAGGQTITERFHAFDTQNPHIYRALERRAARHLAAGLTRISLKDLFEDLRRQLPHGAGGLNNNYTALYARKLIAEHPQWAAAFELRQRRAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5Y5</accession>
    <name>A0A0F7N5Y5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GAF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_19440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
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        </location>
    </feature>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
    <sequence length="201" mass="21708" checksum="BE8C708C34A742CB" modified="2015-07-22" version="1">MTFDAASGLNVLTPDTDTDLQQRMARLHGLGLGAPDPQFDAFAADLARDADVPYAMVNLRTHLQFFAGLHSPPPGGDLPVVGRQMDHDHGYCPEVIDRRNALVLPDVTARPRFASNPVVDLIGIRTYAGAPLIDEPTGIVLGTVCFVGPEPRDKSTGRAALEFITNRRDALMELIYARAARRPAPPTDPPNSRGGNDHAPR</sequence>
</entry>
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                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
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        </source>
    </evidence>
    <sequence length="389" mass="42084" checksum="C7939FC27ACAB8B9" modified="2015-07-22" version="1">MSTLSRRALVAGASASGLALALPHSAAAEPVAGTAESAPAAGAAVAYAAFRLVRLRPGDPAVPEVTLPDGYEFVPGDRYHVASRAEYYSFVRGPAAPDGIEVSVRWPGVTVAAVVHMDTRLRLRRDRADRHRFAFTLPVTQSSADANQPTLQIWSHPDISPGMYYKLDHNDPDRVAGPWTTVAWPANQARSQLHQLVAAHRILVDSGLKATAAAKGHRWFVAGFETNNTLHADNPPHWHISYNSGSDFDSPTHNTHFWLDAEAKNFYNGMDVTGLGRLRHYVGDPARLYDFAGDANGGRGELVATMTIREDGGIDIAPPAGPVYALAAGRDGSLIEEVTVVRDGSPWLRVATEDRYRVGIMTVRTHGLSDPADNDFTLLRYDPLTGVLV</sequence>
</entry>
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                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">CNQ-509</strain>
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        </location>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <sequence length="318" mass="33160" checksum="9B43A486933E74B0" modified="2015-07-22" version="1">MTQPPRSSGADDGHPEVEELADLAEGLTSPARTQQLHRHLDECATCRETRDALDGVRGLLGSLPEPAPMPAEIAGRIDAALAAEARYDADVSAVDVSRETAPPETHVPAPRESVSRETRSRRSHRRPAAHRADATGPGRPARRWPRVLLGAAGAAALVALTVVLFQLPESGGNDDSAADMTANQEQSQGNAPKVAPSAGSQGPLGADSLETRVLGMLQQPERREGGGAGEGTADTGDDPLVAEGDDPQVPECVRAALNRSEAPLAAGTDTYEGSPAYVVVLPHPGDAQRVDAYVVDSSCAASPDQPGEILHSDTFQRP</sequence>
</entry>
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    <accession>A0A0F7N655</accession>
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                <person name="Kaysser L."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">CNQ-509</strain>
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        </location>
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            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AKH84080.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="177" mass="19919" checksum="C0325062522DCC3E" modified="2015-07-22" version="1">MRTGVDRADDGDTRVRPGTEDDLEELTRIYNHYIVETPITFDVEPLTVDQRRPWLESHPGRGPHRLLVAEEGGKILGYATSSPFRPKPAYSTSVETSVYLAPEHVGRGVGGLLYTSLFEVLEQEDVHLALAGVALPNEASERLHLRFGFRPVGVYEEVGRKFGRFWDVAWFQKTLAP</sequence>
</entry>
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                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">CNQ-509</strain>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="3"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <sequence length="188" mass="20911" checksum="8C5D6705FDDA0745" modified="2015-07-22" version="1">MRSVTYSMAVSLDGFVTGPDGGIDWGAPSEEVFRHSIEEIQDVGVHLMGRRLYETMLYWETAAQDPSSLSETEREWIRLWNPLPKVVFSHTLTEVEGSARLASGGLAEEIARLREEPAEGDIAIGGATLAAEAAELGLIDEYRIRVNPVLLGGGTPFFARIERQVDLELVETRTFDSGVVYLHHRVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6C8</accession>
    <name>A0A0F7N6C8_9ACTN</name>
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        <submittedName>
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        </submittedName>
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            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH84175">
        <property type="protein sequence ID" value="AKH84175"/>
        <property type="gene ID" value="AA958_20510"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_20510"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH84175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="104" mass="11326" checksum="7A8F973F6D547656" modified="2015-07-22" version="1">MAEGHACGLFLHQNFQTDGGRMCLGFSLFSFADHGSLPEIGNGSGRYGDFFKIVFLPQCAQQCSLLKHVHHEWDGVRADNPSVPVSVSVQSDHFIGPTGVHEIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6H2</accession>
    <name>A0A0F7N6H2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptide ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_17315</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016980.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_17315"/>
    <dbReference type="EnsemblBacteria" id="AKH83676">
        <property type="protein sequence ID" value="AKH83676"/>
        <property type="gene ID" value="AA958_17315"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_17315"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3641"/>
    <dbReference type="OrthoDB" id="162819at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519255" evidence="1">
        <location>
            <begin position="39"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="2">
        <location>
            <begin position="86"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH83676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="510" mass="54344" checksum="CC4FFC8BADCFDFA1" modified="2015-07-22" version="1">MTGASRASGRGPARRDFLAMAGLGATAVLLSGCGVGSAAPSGALRAAFGQPVTDLDPYNAATAVDEASLIVKRLVFDTLVRREGAELAPGLATGWRREGDTKWVFTLRRGAVFHDGSEVTARDVVACLKHTQQVASAQTPLWATVAGAEAPDDHTVVFTTDGPLGSLPVNLTLLFIVPARLVADPEQKRSPVGSGPFRVTGFTPSTSVELARFDDYWGGRAELPAVSMPYIAETSTAITALLGGDIDLLWPVPPDQLPEVTGVSGITVEPVPSWTYYFNWFNCGREPFNDPDVRRALCQAVNVPQIVDSLFGRGGKQMRAPIPETVAGFAPQRPWPYDPDEARRLLARAGLGRGFSTSMMWFDATGPLSRELAQALISAWAGIGVTVEPQSIEKAMWLERLNGLDWDMNLQTNTVTTGDAAFTIGRLYTSEAKRLGYANGDLDAVLARAAGAPEGPERDALYGEACGTIWSDAVGLFPVTLVTGYGRAKELTGFTPAPNNQPDLAVVGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6U4</accession>
    <name>A0A0F7N6U4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sugar phosphate isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_10230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015884.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_10230"/>
    <dbReference type="EnsemblBacteria" id="AKH82542">
        <property type="protein sequence ID" value="AKH82542"/>
        <property type="gene ID" value="AA958_10230"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_10230"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2156"/>
    <dbReference type="OrthoDB" id="1478083at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="34"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="283" mass="30426" checksum="5910E6998A4772B2" modified="2015-07-22" version="1">MSTGQPAGGPARLSLNQETIRQWSLPELADGCTAAGVRGVGLWRAPVQEFGVEAAAKLFRDAGLTVTSLCRGGFFTTGDPGERATALDDNRRAIDEAATLGTDTLVLVSGGLPAGSRDLHGARERIADALGALAPYAAERAVRLAIEPLHPMYAADRCVVSTLAQSLDLAERFPADRVGVVVDTYHLWWDDTVAAQITRAGESGRIAAFQLADWVTPLPEGVLLGRGQLGEGSVDLRWFRERVDEAGYTGFVEVEIFNPGLWARDGSEVLAEIVERYKRLVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7P4</accession>
    <name>A0A0F7N7P4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Prephenate dehydratase</fullName>
            <ecNumber evidence="3">4.2.1.51</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AA958_15720</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H(+) + prephenate = 3-phenylpyruvate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:21648"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:18005"/>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
            <dbReference type="EC" id="4.2.1.51"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-phenylalanine biosynthesis; phenylpyruvate from prephenate: step 1/1.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.51" evidence="3"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016726.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_15720"/>
    <dbReference type="EnsemblBacteria" id="AKH83414">
        <property type="protein sequence ID" value="AKH83414"/>
        <property type="gene ID" value="AA958_15720"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_15720"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3313"/>
    <dbReference type="OrthoDB" id="1280729at2"/>
    <dbReference type="UniPathway" id="UPA00121">
        <property type="reaction ID" value="UER00345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004106">
        <property type="term" value="F:chorismate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004664">
        <property type="term" value="F:prephenate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009094">
        <property type="term" value="P:L-phenylalanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008242">
        <property type="entry name" value="Chor_mutase/pphenate_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001086">
        <property type="entry name" value="Preph_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018528">
        <property type="entry name" value="Preph_deHydtase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00800">
        <property type="entry name" value="PDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001500">
        <property type="entry name" value="Chor_mut_pdt_Ppr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00857">
        <property type="entry name" value="PREPHENATE_DEHYDR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51171">
        <property type="entry name" value="PREPHENATE_DEHYDR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0584">Phenylalanine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prephenate dehydratase" evidence="10">
        <location>
            <begin position="5"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="11">
        <location>
            <begin position="198"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="site" description="Essential for prephenate dehydratase activity" evidence="9">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001500-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AKH83414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="311" mass="33085" checksum="4137443E51C20D08" modified="2015-07-22" version="1">MSASRFTYLGPEGTFTEAALRTLPEAATRELVPMVSVPAVLDSVRGGGAAGALVPIENSVEGGVTATLDELALGEPLMIYREVLLPIAFALLVRPGTKLADIKTVTGHPVAQPQVRRWLAGHLPDAVWESSASNADGARQVQEGRVDGAFAGEFAASVYGLEPLVSDIHDAENAETRFVLVGRPARPAAPTGADKTSVVIWLGDDHPGALMELLQEYAVRGVNLLRIESRPTGEGIGRYCFSVDCEGHITDRRVGEAMMGLKRICPRVRFLGSYPRAGLSPADVQPLRAGTSDTAFAEASDWLTRCLDGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7Z5</accession>
    <name>A0A0F7N7Z5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_12460</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016247.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_12460"/>
    <dbReference type="EnsemblBacteria" id="AKH82912">
        <property type="protein sequence ID" value="AKH82912"/>
        <property type="gene ID" value="AA958_12460"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_12460"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2618"/>
    <dbReference type="OrthoDB" id="807474at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005693">
        <property type="entry name" value="Mce"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024516">
        <property type="entry name" value="Mce_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11887">
        <property type="entry name" value="Mce4_CUP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00996">
        <property type="entry name" value="Mtu_fam_mce"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="MlaD" evidence="3">
        <location>
            <begin position="39"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Mce4_CUP1" evidence="4">
        <location>
            <begin position="122"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF11887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH82912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="421" mass="43414" checksum="4CCBDF3F5FCAD365" modified="2015-07-22" version="1">MITRSVIVKNIVFALVAVLVIGYIGVRYADLGRYVGMRDYYTVRVELAETGGLFPHAEVTYRGVSVGRVGPIELTGTGVEAELRIRDSAPPIPADLSAEVANYSAVGEQYIDLKPAADSGPYLADGAVVGRQHTATPAPVTNLLTSVDSFATSVDTGELRTVVDELGDALAGQGDNLQRLLDTGSEFIRAADAALPYSTRLMIDGETVLRTQNDSGEALQEFAKGAEELTAQLKRSDGDLRRVVEAGPGAASQVTGLLRDLDPSLSILLANLLTTSEIAVTRQDGLEQLLVQLPQVAAAGSTAITSDGARFGMALSFFDPLPCTRGYGSTAYRNGLTTSPAGFNTAARCTAPASSGVNVRGSAHSPGGGGVPKPARPGSGLADDRPGTRAAPGALPGAPGLPAVGDGPTDMAGLLGLKEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N867</accession>
    <name>A0A0F7N867_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AA958_12855</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016301.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_12855"/>
    <dbReference type="EnsemblBacteria" id="AKH82967">
        <property type="protein sequence ID" value="AKH82967"/>
        <property type="gene ID" value="AA958_12855"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_12855"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2704"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025666">
        <property type="entry name" value="PQQ-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018391">
        <property type="entry name" value="PQQ_beta_propeller_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002372">
        <property type="entry name" value="PQQ_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01011">
        <property type="entry name" value="PQQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13360">
        <property type="entry name" value="PQQ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13570">
        <property type="entry name" value="PQQ_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00564">
        <property type="entry name" value="PQQ"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="16"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="301"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="453"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="328"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="396"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="487"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH82967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="879" mass="90395" checksum="51FDE08F6B61402E" modified="2015-07-22" version="1">MVEQLAQHDPRRIGPFEVLGRLGAGGMGLVYLARSASGRRVAIKTVRTELAEDQLFRVRFTREVEAARAVSGFYTAPVVDADPRAAVPWLATAYMPAPSLEEMVNDCGPLPPQAVRWIAAGVAEALQSIHGAGLVHRDLKPSNVLVLEDGPRVIDFGIASGVSNTRLTMTNVAVGTPAYMSPEQARDSRSVTGASDVFSLGSTLVFAATGHAPFHGANPVETVFMLLREGPDLEGLPGELRPLIEACMQMTADHRPSPEALQSDLAPHLFGAGGDDSGTASAWLPRTAIRMIEARRGAAATLGGAGAHGGSSGRHGGSRGPSASRRSMPPRPAHPPSAGPGGAPQAPPQPAPHSVPQSAPHSAPQSAPARHAGPPGGPAHGPGAGPAHAAPGGAQGAPPAAPPERVPPQSAAAPPQAPGADVQLAGAAVPIGPGPRVVDARAARARAAADGGLDLGWARPRGSAAAPGTQQAPAAHSGGHAPAASSPATAPAPPAEAAPQEPPRWRPWRFRMSNDVWGKPVVSGNLLYVTSFEVHALDVTSGRRQFKTREVAWSMALSEGVIHASDGPSLYALDAADGREHWRQGTGGWVYSLQVAAGTVVTGTRGGGLQARHAATGEPLWEHSGAQTEFETQEAGPLAHDGTVYVWGDGRLRALDTRSGAERWSYPIGDAAACGGVPVRLLPADDVAAGPTVFASAGKRVLALDAAYGTLRWTFEAPAVILSPPAYAPGAALTGGGVFVADHLGTVYALDAADGRERWRIATEARQSIEPVLVADNHVHVGSGAALYTLDAVAGTPMWRFATRGDLIGAPVAADGRVHFGSADHCIYAVDAVGGQLRWKLATDGEITGSPVVANGVVYACSKDRCVYALDAGKGTARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8Q9</accession>
    <name>A0A0F7N8Q9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Endonuclease NucS</fullName>
            <ecNumber evidence="2">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">nucS</name>
        <name evidence="3" type="ORF">AA958_24915</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Cleaves both 3' and 5' ssDNA extremities of branched DNA structures.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NucS endonuclease family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="2"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018161.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_24915"/>
    <dbReference type="EnsemblBacteria" id="AKH84910">
        <property type="protein sequence ID" value="AKH84910"/>
        <property type="gene ID" value="AA958_24915"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_24915"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5252"/>
    <dbReference type="OrthoDB" id="1002946at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00722">
        <property type="entry name" value="NucS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002793">
        <property type="entry name" value="Endonuclease_NucS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38814">
        <property type="entry name" value="PTHR38814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01939">
        <property type="entry name" value="NucS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH84910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="223" mass="24468" checksum="481BE2C5566D5D1F" modified="2015-07-22" version="1">MRLVIARCSVDYAGRLTAHLASAPRLILVKADGSVSVHADDRAYKPLNWMSPPCTLKEGEQDGVAVWTVENKAGEKLIITIEELLHDSSHELGVDPGLVKDGVEAHLQELLADRMEALGEGWTLIRREYPTAIGPVDILGRDEKGTTVAVEIKRRGEIDGVEQLTRYLDLLNRDPLLAPVRGVFAAQEIKPQARVLAADRGIECAVLDYDALRGTDDGKLKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N928</accession>
    <name>A0A0F7N928_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_18990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017229.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_18990"/>
    <dbReference type="EnsemblBacteria" id="AKH83934">
        <property type="protein sequence ID" value="AKH83934"/>
        <property type="gene ID" value="AA958_18990"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_18990"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3986"/>
    <dbReference type="OrthoDB" id="2024961at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046094">
        <property type="entry name" value="DUF6112"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19607">
        <property type="entry name" value="DUF6112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="104" mass="10288" checksum="5CFA6B29211BBE4C" modified="2015-07-22" version="1">MPLPLADRLIHLAYDPGISPKGGGLPGLSVLKNVVNSINLFGIVAVVGALAVSLGVWAWGHHTGGHQAEANGKKGAVVAAGAALGLGAANGIVSFFSNLGSQVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N943</accession>
    <name>A0A0F7N943_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_19110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH83949">
        <property type="protein sequence ID" value="AKH83949"/>
        <property type="gene ID" value="AA958_19110"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_19110"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4016"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH83949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="62" mass="6469" checksum="E89103F36055344F" modified="2015-07-22" version="1">MGKNARPFLAVLALTFLGGWCAAGSRKGSTSLQRHLAQTVASAQYLTLSGILGERGFGRSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N947</accession>
    <name>A0A0F7N947_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH_Tnp_4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_22735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH84551">
        <property type="protein sequence ID" value="AKH84551"/>
        <property type="gene ID" value="AA958_22735"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_22735"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4781"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011518">
        <property type="entry name" value="Transposase_36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027805">
        <property type="entry name" value="Transposase_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07592">
        <property type="entry name" value="DDE_Tnp_ISAZ013"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13613">
        <property type="entry name" value="HTH_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_Tnp_4" evidence="1">
        <location>
            <begin position="292"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="368" mass="40573" checksum="85EDDD009A178C0A" modified="2015-07-22" version="1">MPGPGIHGEQRQWPAVSGGCNTIAATTTRTGLRVEAMLDTGSYPTGISITRDQLKALPITPHDRHGRWNYSIAPTGAAAPVPGADDSAAARRQTLTMLADPRLTGMTAGELRELHARLAPAQAARAEQHRYVLRGGRRVATTGRSRALLGDQDEVLITVLYLRQVCPQKVLCDLLGINPVTIGQAIKATRQLLDELKITITPTVVRYFTRAQDLRDWLDGVTDVPATMTSPQQQALTDPHLTGLEREALHQLLEELIVPYAAAIERRRHRQRGGNRRPGTRGGVFRQKITDGDRILATLLHRRRVCTLDALAELFGVSRSTLWNAIRDVQPILDDRRIDIATSPHRYVTAREALDAVRDGTDNHQVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N975</accession>
    <name>A0A0F7N975_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Asp_Arg_Hydrox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_19365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017279.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_19365"/>
    <dbReference type="EnsemblBacteria" id="AKH83984">
        <property type="protein sequence ID" value="AKH83984"/>
        <property type="gene ID" value="AA958_19365"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_19365"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4071"/>
    <dbReference type="OrthoDB" id="1564693at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018193">
        <property type="term" value="P:peptidyl-amino acid modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007803">
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    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05118">
        <property type="entry name" value="Asp_Arg_Hydrox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Asp_Arg_Hydrox" evidence="1">
        <location>
            <begin position="21"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="323" mass="34913" checksum="EB53592B8464D4A7" modified="2015-07-22" version="1">MTTSLTAATEAAQLSPVFDADKLATELAAVTAHTWNVQRTHTYGGQVGLPAAIDWRVLPLRSLGGDPQRTDPGGPGPQSFAPTRWLSRLPYLGEILDSVPAPLNAVRLMALGPGAVSDPHRDPKYRLDRGIVRLHIPIVTDPAAVLVLDGVEHCWQPGTCWYGDFSREHLVRNTGTTVTRVHVVIDALLTADLAAWFPDAWQELLTHGEVLFNRTSPARSPDWPGGLPYEALLPSGFADFDSPAPLDGSLIPARIDRDADDVLALTVAGRTFALVPVDGAGEFRFSGWSEQRTLQPRTGGLTLRVRRGRALADRHVTAAPRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N991</accession>
    <name>A0A0F7N991_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Efflux ABC transporter, permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AA958_22985</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017848.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_22985"/>
    <dbReference type="EnsemblBacteria" id="AKH84591">
        <property type="protein sequence ID" value="AKH84591"/>
        <property type="gene ID" value="AA958_22985"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_22985"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4842"/>
    <dbReference type="OrthoDB" id="324902at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="246"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="296"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="336"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="419"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="671"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="716"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="770"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="8">
        <location>
            <begin position="278"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="8">
        <location>
            <begin position="702"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="460"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="478"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH84591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="804" mass="80892" checksum="F1AE5E28A22BF644" modified="2015-07-22" version="1">MVRAEVGRRRVQTTVMVLTTVLTVAAAVLATGLLVGSRAPFDNAFARQQGAHLTGQFDAEKATAARVRATAGAEGVTAAAGPYGITSLRLHVTTAPEGAKSPPLTVAGRKSAGGEVDDLDVTEGRWVRAPGEIVIESGARSRDMALGARVEVDGVPDGPVLTVVGIAESVGESADGWVVPAQLGALTAEGARPDRQMLYRLTGADTRGEVASARKAVAAAVPAGALTGSQSYLDVKQAANEDTAAFIPFVTAFALLGLAMSVLIVSIVVSGAVGAATRRIGVLKSLGFTPSQVARAYVAQAAIPAAAGAVLGAGLGNALSVPLMNEVASAYGTGRILIPLWVSLAVPAAVLTLVAATALGPALRAARLRTTAALSVGRTPRAARGRRVRHALGRLPLPRAVVLGLAGPFARPARSATMAAAVTFGALAVTFAVGLGTSLLALEREGTPDGAGDVTVHRMMPPPGAGVPGAPGGPGGTEAGPGTPPQPPAPAAGPASGASPAEVTAAIDARPETAHHFATAQTEVTVSGRKGAVPLVTYRGKAPADGYRMAAGRWFTAPGEAVAPARFLQATNTALGDTVTLRDGDRTAELRIVGEVFDLNDEGLAVRTAHASVSGLVPAWEPDEYVVDLAPGTDRGTYLTALNAALEPLGAEAMAVAEDGDSPVLVAMQALIAMLTAMLVAVACLGVLNTVVLDTRERVHDLGVFKALGMSPRQTVAMVLTSVAGIGLAAGAAGVPLGAALHHYVVPEMGRSVGTNIPDALVAVYTPAHLVLLALAGIAIATAGALLPATWAAATRTATALRSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9F4</accession>
    <name>A0A0F7N9F4_9ACTN</name>
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        <submittedName>
            <fullName evidence="5">Molybdopterin biosynthesis-like protein MoeZ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_23420</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_23420"/>
    <dbReference type="EnsemblBacteria" id="AKH84666">
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        <property type="gene ID" value="AA958_23420"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_23420"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4937"/>
    <dbReference type="OrthoDB" id="1408716at2"/>
    <dbReference type="Proteomes" id="UP000034283">
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    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008641">
        <property type="term" value="F:ubiquitin-like modifier activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
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        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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            <end position="390"/>
        </location>
    </feature>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH84666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="392" mass="42410" checksum="54A8DD69A6719B1B" modified="2015-07-22" version="1">MSLPPLVEPAPELSVDEVRRYSRHLIIPDVGMAGQKRLKNAKVLCVGAGGLGSPALMYLAAAGVGTLGIVEFDEVDESNLQRQVIHSQADIGRPKAESARDTVLGINPYVTVNLHQERLDSSNVMEMFAEYDLIVDGTDNFATRYLVNDACVLLGKPYVWGSIYRFDGQASVFWAEHGPCYRCLYPEPPPPGMVPSCAEGGVLGVLCASIGSIQVNEAIKLLAGIGDPLVGRLMIYDALEMQYRQVKVRKDPDCAVCGENPTVTELIDYEAFCGVVSDEAQEAAAGSTITPKQLKEWIDDGENIDIIDVREPNEYEIVSIPGARLIPKDEFLMGNALEGLPQDKKIVLHCKTGVRSAEVLAVLKSAGFADAVHVGGGVVGWVNQIEPDKPVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9I8</accession>
    <name>A0A0F7N9I8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase M15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_23635</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_23635"/>
    <dbReference type="EnsemblBacteria" id="AKH84701">
        <property type="protein sequence ID" value="AKH84701"/>
        <property type="gene ID" value="AA958_23635"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_23635"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4981"/>
    <dbReference type="OrthoDB" id="682655at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.101.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009045">
        <property type="entry name" value="Hedgehog_sig/DD-Pept_Zn-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013230">
        <property type="entry name" value="Peptidase_M15A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036366">
        <property type="entry name" value="PGBDSf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08291">
        <property type="entry name" value="Peptidase_M15_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="SSF47090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55166">
        <property type="entry name" value="SSF55166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519275" evidence="1">
        <location>
            <begin position="33"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="PG_binding_1" evidence="2">
        <location>
            <begin position="47"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M15_3" evidence="3">
        <location>
            <begin position="117"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH84701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="244" mass="25503" checksum="482BDBC0B3BAC3F5" modified="2015-07-22" version="1">MLRRTVRLILSIAMIAAAGVVGTVATAGTAQADSCYTWNRTLSEGMSGSDVTQLQIRVAGHVTSGEILAIDGNFGPRTKAAVAKFQSAYGLSSDGVAGTNTFNKIYSLQDADCTPIHFTYGELNKCNSTWGGGAVSAATAKENAKRTMWKLEAMRHALGDVPINISSGFRSVSCNNAVGGASNSQHLYGTAADLVGSPSFCRLAQQARTHGFGGILGPGYPGHNDHTHVDGRSSRYWSAPSCGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9S9</accession>
    <name>A0A0F7N9S9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Stress response protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_15850</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016749.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_15850"/>
    <dbReference type="EnsemblBacteria" id="AKH83437">
        <property type="protein sequence ID" value="AKH83437"/>
        <property type="gene ID" value="AA958_15850"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_15850"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3339"/>
    <dbReference type="OrthoDB" id="1437267at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd06974">
        <property type="entry name" value="TerD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003325">
        <property type="entry name" value="TerD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019303">
        <property type="entry name" value="vWA_TerF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02342">
        <property type="entry name" value="TerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10138">
        <property type="entry name" value="vWA-TerF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="315"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH83437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="530" mass="55678" checksum="A52A8F30DBBAEA94" modified="2015-07-22" version="1">MATAPLAKGANLPVDAPAVRAELSWSEGPGVPDVDASALLLTAAGRVRDDGDFVFYNQPQHTSQAVTHLGKQQAGGRYTDSVEVLLKSLGPGIERVVLCASADGGTFGQVPGLSLRLLDAGTGAELARFDMEATTETAFVGGELYLRGGRWKFRAVGQGYASGLAGLATDFGITVDDSPPPPSPTPPPATLPPPAPAAPAAPPPAPASPTPPHAQPPPAPQAPMPPAPAPAAPAPQAPAGAPPPAPYPPAAPAAPPAPGAYPAPAPAASPAASGGPRLVKGEEHLPVDMRKRLSLRKEQVAISLRKHGAADISARIIVVLDASGSMTRLYAQGVVADVVERMAAVAAELDDDGAMQAWTFASHPARLPDLLLGDLPEWLRLHVRVGQLALFRPRKKRKGLENGQIDMRMVGIQNEEQKVIAEVRAYVRENPAPDPTLVLFFSDGGVYRNAEIERELREAVEEPIFWQFVGLGASDYGVLERFDSLGGRRVDNVGFFSVDDISGLPDPQLYDRLLSQFPGWITAARSARIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NA43</accession>
    <name>A0A0F7NA43_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_16695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_16695"/>
    <dbReference type="EnsemblBacteria" id="AKH83577">
        <property type="protein sequence ID" value="AKH83577"/>
        <property type="gene ID" value="AA958_16695"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_16695"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3512"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="90" mass="9321" checksum="97ECC5D3F16CD1CA" modified="2015-07-22" version="1">MATTAPTTPLSRRTLPTSAGTLGPSEPIDGRPDPQAGDLDLAELESLGGAWGEFSVEESASLGPELLISNMFPPPDLWFADALENAGKLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAC5</accession>
    <name>A0A0F7NAC5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_21780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017651.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_21780"/>
    <dbReference type="EnsemblBacteria" id="AKH84389">
        <property type="protein sequence ID" value="AKH84389"/>
        <property type="gene ID" value="AA958_21780"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_21780"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4587"/>
    <dbReference type="OrthoDB" id="1320028at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="2">
        <location>
            <begin position="29"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH84389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="502" mass="53466" checksum="E012EE1BEFDF5B83" modified="2015-07-22" version="1">MSDSWATSAELRDFHRSLDLHVDVRAGTRGAGAALIRSLRDAVRTGRLAPGTRLPSSRALAADLGVARNTVAGAYAELVAEGWLTARQGSGTRVAARSEARRVTTRAHARAHEPPLHPLDRQAAYNLLPGAPDAARFPRAAWAAAARRALTAAPSAAFGHQGPGGRVELRRALAGYLARARGVYAEPERIVVCAGFTGGLRLLAEVLRAEGARRVAVEPYGLGLHRRLLTDAGLRTVPLPYDEEGIATAALPATGAGAVLLTPAHQFPTGVPLAPDRRAAAVDWARATGGVVLDDDYDGEFRYDRQPVGALQSLDPEHVAHLGTASKSLSPALRLGWMVLPERLLRGVHEVQSLSRTPPGVVDQLTLAEFLDSGGYDRHVRAARQRYRRRRDRLVAELARRAPRVRVTGIAAGLHAVVRLPPSTERRVLARAAREGLAVARLGAYEYGNAAWEEGGDFTAPPPAGEAPGTQGEALVVGYGTPPDHLYPGALEALCRVLEAET</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAE0</accession>
    <name>A0A0F7NAE0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_21900</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017666.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_21900"/>
    <dbReference type="EnsemblBacteria" id="AKH84404">
        <property type="protein sequence ID" value="AKH84404"/>
        <property type="gene ID" value="AA958_21900"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_21900"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4612"/>
    <dbReference type="OrthoDB" id="1108236at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="16"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="277"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="311"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="375"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="419"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="456"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="18"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="479"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH84404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="498" mass="52374" checksum="EC6BB742B8AAF2C1" modified="2015-07-22" version="1">MTFQNASVAGPDRRRWIALAVVLTASFMDLVDATIVNIAIPSIREDTGASFGAIQWITAGYALAFAIGLITGGRLGDIYGRKRVFLLGMGGFTAASLLCGIAADPAMLVGSRVLQGAMAALMVPQVLSIIHVTFPAEERGKVFGMFGAVAGLGAVSGPMIGALLTEWDLFGLAWRPIFLINLPVGIAGLILGRRFISESTAPDALRLDLRGVLLATAGLLMLLYPITMGHENDWPAWGFVSMAASLPVFAAFVAYQKRKQRADGSPLVELTLFRVKSFAAGIGVQLAFSTALGIFFLVWTLYMQLGLGWSALHAGLTGLPFSLGCSVAAGMSVQKLTPLFGRKVLHGGAVMMVSGALLYLAASDRYGTEISTWQMVLPLTLLGAGMGLVFAPLTNAVLSGVPRRHAGSASGLINTVNQLGMALGLGLVSVVFFGAMDEPTALQEAGPAFAGAFENAMWWVIAILGVVYALLFALPKRNPAEEPEPTAAAEQKEDLVTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAI8</accession>
    <name>A0A0F7NAI8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pilus assembly protein CpaB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_22495</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017767.1">
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    <dbReference type="InterPro" id="IPR017592">
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            <end position="103"/>
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        <location>
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            <end position="237"/>
        </location>
    </feature>
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            <end position="237"/>
        </location>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH84508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="237" mass="25328" checksum="8E889998AEFD088F" modified="2015-07-22" version="1">MNSRQRRGIILVLLSVLVALGAFAGVLAFVSDVESKVGDEATAYRLTTDVEAYEPLEPDQYEKTTMPKRWLPDTAVTDPDELAGKVALTPLKQGSLLQSDMVSGRPDLEPGQQEIAIMIDASTGVAGKITPGARVNIFATFDAQGDGDKPVSQVIVAGARVIDVGELTPIERTGDDDPRADEGEAVPITFALGTSDAQRVAYAESFATHVRLALVAPGEEDTDIAPEDRTYTLDEDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAN1</accession>
    <name>A0A0F7NAN1_9ACTN</name>
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    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="70"/>
            <end position="102"/>
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        <location>
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    <feature type="transmembrane region" description="Helical" evidence="7">
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        <location>
            <begin position="288"/>
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            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH85590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="340" mass="34967" checksum="70CA31A505672606" modified="2015-07-22" version="1">MLSKSDSLSAPAPEKPQGNGNAADWHSRLDFRLLALVGVLGLLVAVGALTKPDQFLDVDNFRLILTQSSAIGVVTIGVTLVIIGGGIDLSVGAIVALASVWATTQATQDYGLTGMLFCAIAVGIGCGLVNGVLIAYGSLVPFIATLAMLASARGFAEQMSDGQTQIVEVDAVLDLGNADARILGIPYLVLIFLGVAALGWVLLNRTTFGRRTVAVGGNPEAARLAGIDIKRQRLLLYGLSGLCCGIAAFMLIVLAGSGQNTNGNLYELDAIAAAIIGGTLLSGGRGTITGSVLGVVVFTTITNLFALNNVQSDVQKIAKGAIIVAAVLIQHHTSRKSSTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
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        <lineage>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Albersmeier A."/>
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                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH83772">
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        <property type="gene ID" value="AA958_17905"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_17905"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3771"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
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            <end position="36"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="47"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH83772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="97" mass="10991" checksum="27B6ADF97D857BEE" modified="2015-07-22" version="1">MNEQTVHLADSGDTVGAVVGAVGAAGFFALLIVVVWQIAATWRAKMLAAREEQYRQLAIKYQQLLEDNLELHRRSIDELTEARRSITSMEKMMREIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAW4</accession>
    <name>A0A0F7NAW4_9ACTN</name>
    <protein>
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            <fullName evidence="2">Phosphoesterase</fullName>
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    </gene>
    <organism evidence="2 3">
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        <lineage>
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        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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    <dbReference type="EnsemblBacteria" id="AKH84653">
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    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_23340"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4920"/>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="3"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="281" mass="30023" checksum="08F997CD61C530EF" modified="2015-07-22" version="1">MRIDLHTHSADSDGTDTPADLVRKAAAEGLDVVALTDHDGVGGHAEAIEALPPGLTLVPGMELSCDLDGISLHMLAYLFDPEEPELTRERDAVRNDRVRRARLMTERLIELGVPITWQRVQEIAGEGAIARPHVASAMIEAGVVDSVQDAFTDEWIGSGGRAYVEKHELDPFDAIRLIKGAGGVTVFAHPLAVKRGVCLPESAVAELAAAGLDGIEVDHMDHDEETRARLRGTAADLGLLATGSSDYHGARKTCRLGEFTTAPEVYEQIVDRATGATPVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAZ6</accession>
    <name>A0A0F7NAZ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_23125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017871.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_23125"/>
    <dbReference type="EnsemblBacteria" id="AKH84614">
        <property type="protein sequence ID" value="AKH84614"/>
        <property type="gene ID" value="AA958_23125"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_23125"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4875"/>
    <dbReference type="OrthoDB" id="1844050at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="96" mass="10642" checksum="CDB7AD34E58E495B" modified="2015-07-22" version="1">MTLNEELTAAQRCVDDLVRTVSRLEQRMGTGALELRRVRTDADHLRESLALLREVSAQGPEKEGPTLVPIPDQPYDHTLWRDADDEGLGAGGRHAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBA7</accession>
    <name>A0A0F7NBA7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminoglycoside phosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_19345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017277.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_19345"/>
    <dbReference type="EnsemblBacteria" id="AKH83982">
        <property type="protein sequence ID" value="AKH83982"/>
        <property type="gene ID" value="AA958_19345"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_19345"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4067"/>
    <dbReference type="OrthoDB" id="1457558at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="41"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="328" mass="35933" checksum="28E981541C5A18AD" modified="2015-07-22" version="1">MDFQPVERAMEAFQQSLTAAEIGKVCRRAFGGAAVPVSAVELGTGMYNNVYRVALAGRDRPVILRVAPEEGRQFRSERHLMRNEYGSVPWLAVIAPLMPQVLAVDWSHEVIGRDWMIQTYLDGVPAPEHLGRYPRRAWPAFFRQMGVIARSVHDVRGPFFGPVGGPGYGTWSEAVITSLEEIAADLDGAGLDAADVRKVAAVAGHERAVLDEVTEPGLLTGDLWTVNVMLDSGAAEPTITGVLDMDRTWFGDPAADWTIRMALAKQDERVAFWEAYGQRDRSPAAVWRSLVYEVRHLGAVRLERHRLGNAAGVENTYGAVAAVLADLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBH1</accession>
    <name>A0A0F7NBH1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RNA polymerase sigma 70</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AA958_24330</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Interacts transiently with the RNA polymerase catalytic core formed by RpoA, RpoB, RpoC and RpoZ (2 alpha, 1 beta, 1 beta' and 1 omega subunit) to form the RNA polymerase holoenzyme that can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018070.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH84818">
        <property type="protein sequence ID" value="AKH84818"/>
        <property type="gene ID" value="AA958_24330"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_24330"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5126"/>
    <dbReference type="OrthoDB" id="1914729at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="7">
        <location>
            <begin position="12"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="8">
        <location>
            <begin position="111"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="74"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH84818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="299" mass="32327" checksum="A15020FCC83E4614" modified="2015-07-22" version="1">MSDHDWLAERFESDRPRLRALSYRMLGSAAEADDAVQEAWIRLSRSRTDEVENLSGWLTTIVARVSLNMLQSRKSRPEDLVDTTEAGEPHGEAAPDDPEEEAVLADSVGVALLVVLDTLTPAERLAFVLHDMFAVPFEEIATIVDRSPAAARQLASRARRRVQRAAPLARTAAVGVYDKSADTPKTGKSDLASAFLAASREGNFEALLSMLDPDIVLRSDATAVQMGVDAELRGADAVTRVFAGRAWAPVPALIDGTAGLVWAKGGRPRLAFRFTVDDGRITAIRIQAELADVDIALAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBH5</accession>
    <name>A0A0F7NBH5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_19835</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017347.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_19835"/>
    <dbReference type="EnsemblBacteria" id="AKH84057">
        <property type="protein sequence ID" value="AKH84057"/>
        <property type="gene ID" value="AA958_19835"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_19835"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4180"/>
    <dbReference type="OrthoDB" id="1086845at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009218">
        <property type="entry name" value="HD_phosphohydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21174">
        <property type="entry name" value="PTHR21174"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF035170">
        <property type="entry name" value="HD_phosphohydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH84057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="231" mass="25268" checksum="55CFFE9B473B2DFA" modified="2015-07-22" version="1">MVTMPAPGDHQHAPSAPEPVAPALLDRWTALLTRCRSGAAAPDPVPYGKNLLERWGEPQRRYHTAEHLAAVLDRIDELADHADDPDAVRLAAWFHDAAYRPERSENEERSARLAQVALAEAGVEAERVAEVTRLVRLTVTHDPASGDHNGEVLCDADLAVLAGTPTEYAAYAAAVREEYGFVPADAFRKGRAMVLRQLLGLPRLFRTETGYARWEAAARHNVGTELELLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBM5</accession>
    <name>A0A0F7NBM5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glutaredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_20185</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017406.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_20185"/>
    <dbReference type="EnsemblBacteria" id="AKH84117">
        <property type="protein sequence ID" value="AKH84117"/>
        <property type="gene ID" value="AA958_20185"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_20185"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4251"/>
    <dbReference type="OrthoDB" id="2001991at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008554">
        <property type="entry name" value="Glutaredoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05768">
        <property type="entry name" value="Glrx-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH84117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="94" mass="10834" checksum="D108D8B793A5E538" modified="2015-07-22" version="1">MSLLRRKSTASAPAPADRTVTLIGKPGCHLCDEAREVVVSVCAELGAGWEERDITRDEELYRRYWEQIPVVLVDGEQHDFWRVDPERLRRALRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBS7</accession>
    <name>A0A0F7NBS7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP synthase epsilon chain</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">ATP synthase F1 sector epsilon subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">F-ATPase epsilon subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">atpC</name>
        <name evidence="11" type="ORF">AA958_24880</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7 8">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.</text>
    </comment>
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        <subcellularLocation>
            <location evidence="1 7">Cell membrane</location>
            <topology evidence="1 7">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 8">Belongs to the ATPase epsilon chain family.</text>
    </comment>
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    </dbReference>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
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        </source>
    </evidence>
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</entry>
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        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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        </location>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="209" mass="21653" checksum="CACC0B9FFF96F9B0" modified="2015-07-22" version="1">MESQARGGTRWKRFAVVMVPSLAATAAIGVALSQGALAASFSVSGQEFKVTADRLEGVGFVQYSGVDSGHDLEGNEATRPVAISAFKEAEINGMCQSVVTPDVPLIGSVSLMLTAGDEKPVEAKNLYIDIAQLDADATFENINIGVAAGSSTKGPGIGKGDKANPNGFAQEADRAVLTDVKQTAWATSAGTFKLSGLSMKLHKGVKECF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBX9</accession>
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    </gene>
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        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
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        <location>
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            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <sequence length="272" mass="29806" checksum="E279BEA1199ED6E6" modified="2015-07-22" version="1">MSDDGIADGPHGTSPLPDPTAPHASRTYDYHLGGSDNLGPDRALVDEVEATFMPDVKMRVRAQRLFLERAVRYLVGEAGIRQILDIGCGLPQRRMPNVHEIAHGIAPDTRIVYVDYNPVAVAHMQALHADGILTVAFAGDVRRPELILTHPDTRAVLDLDRPVAVLMVGLLHFLPDEDDPADLVARVRRGVVPGSYLAVSQISAELDSRVSRLTKAWACGATPMVERSRAELERIIDGWEPVDPGVVVAHRWRPRPPDRTEGNAYALVAVKP</sequence>
</entry>
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    <accession>A0A0F7NC64</accession>
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        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <location>
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        </location>
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        <location>
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            <end position="217"/>
        </location>
    </feature>
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        <location>
            <begin position="124"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH86070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="217" mass="23759" checksum="BC7AE2824309ED68" modified="2015-07-22" version="1">MRVLIVEDHRELAETVATGLREDGMDTDLAYDGQEAIDRATSSEYDVIVLDRDLPRLHGDEVCRVLTRHGSRTRVLMLTASITVADRVDGLGLGADDYLTKPFAFAELIARIRALGRRPPNAVPPVLTRGDLTLVPAQHLASRGGRRLDLSRKELAVLELLLSAQGAVVSAEELLERAWDGGADPFTNAVKVTVSRLRRKLGDPPVIETVPHAGYRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCA4</accession>
    <name>A0A0F7NCA4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA polymerase sigma factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_25985</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the sigma-70 factor family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018340.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_25985"/>
    <dbReference type="EnsemblBacteria" id="AKH85099">
        <property type="protein sequence ID" value="AKH85099"/>
        <property type="gene ID" value="AA958_25985"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_25985"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5471"/>
    <dbReference type="OrthoDB" id="1857862at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012845">
        <property type="entry name" value="RNA_pol_sigma_FliA_WhiG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000770">
        <property type="entry name" value="RNA_pol_sigma-SigE/K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02479">
        <property type="entry name" value="FliA_WhiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00715">
        <property type="entry name" value="SIGMA70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00716">
        <property type="entry name" value="SIGMA70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="1 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RNA_pol_sigma70" evidence="6">
        <location>
            <begin position="66"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_sigma70" evidence="7">
        <location>
            <begin position="234"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH85099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="269" mass="29847" checksum="8126E841AF6B5807" modified="2015-07-22" version="1">MPQHISGSDRAASRTAPSSVDELWRSYKETRDGRLREQLILHYSPLVKYVAGRVSVGLPSNVEQADFVSSGVFGLIDAIEKFDPERAIKFETYAITRIRGAMIDELRALDWIPRSVRQKARAVERAYATLEAALRRTPSEAEVAAEMGIQLEELHGVFSQLSLANVVALEELLHVSSDNGDRLSLMDTLEDTAADDPVEVAEDRELRRLLARAVNTLPDREKTVVTLYYYEGLTLAEIGQVLGVTESRVSQIHTKSVLQLRAKLADSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCH6</accession>
    <name>A0A0F7NCH6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NB-ARC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_21890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_21890"/>
    <dbReference type="EnsemblBacteria" id="AKH84402">
        <property type="protein sequence ID" value="AKH84402"/>
        <property type="gene ID" value="AA958_21890"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_21890"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4610"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NB-ARC" evidence="1">
        <location>
            <begin position="73"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="794" mass="85587" checksum="43AB5057FA20C7F9" modified="2015-07-22" version="1">MPGHVNRVGGETVAHAVVQARDISGGLHLHQHGQATPVIVPHQLRGGAGHFVNRSRELARLDSLLAEDTARSRTSRVAALTGTGGVGKTSLALHWAHAAQGHFPGGELYANLCGYAAEAPAAPEQVLGHFLEDLGIPAAQVPAVRERRETLFRSLTAERRMLIFLDNAAHSAQVRPLLPGTAASLVLVTSRDDLTGLVTHGDAMRIRVLTFPADDAVTLLRATTADERTGDEGADLSELAGMCGGLPLALRIAAERAAGRPAISLRELIDELRDESARWTVLTADPGEGNEEGTDAMRSVFEWSYRALPPSAARLFRLLGLHPGNEFGLAAAAVLAGLEPARVQPLLETLTRAHLLQRRPGGRYEFHDLVRAYAAELVRREESENDRSAVLARCVAWYLHTADAAQRAIAPYDRWPLDDYVPAPDPAPAFDGYESAFRWYRTESANLVTATRAAADAGAFGIAWRLAVVLRAIYMHQNAFDEWGATARIAVDAARASGEEAGEAEALENLGKAEFQRLRLAAAEECHRGALAIRRRLGDVHGMAVSANALGLLGLRRRRLDEAELRFAEAAEMFRSLGERRWTALMRTNLAETLCDAGRAGDACMLVEQVLADFRDLDDHFGVGNALWLLSRARRESGDPGAAARAIAEALSLAAAEDNRLWQGHWLAESARVALARGRAADALRLARESAAVQQRLGDTAREATALDIAGEACGALGRLEEAAGLHRDAIERFREADAHWQLAHALVNLAEVLGRLGEPARTVWEEAAGALGRFDDPEASALAERVAARLEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCI2</accession>
    <name>A0A0F7NCI2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Potassium transporter TrkA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_30960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019129.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_30960"/>
    <dbReference type="EnsemblBacteria" id="AKH85901">
        <property type="protein sequence ID" value="AKH85901"/>
        <property type="gene ID" value="AA958_30960"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_30960"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6542"/>
    <dbReference type="OrthoDB" id="941006at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026278">
        <property type="entry name" value="K(+)/H(+)_antiporter_KhtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006037">
        <property type="entry name" value="RCK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036721">
        <property type="entry name" value="RCK_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02080">
        <property type="entry name" value="TrkA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005028">
        <property type="entry name" value="KhtT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116726">
        <property type="entry name" value="SSF116726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51202">
        <property type="entry name" value="RCK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RCK C-terminal" evidence="1">
        <location>
            <begin position="72"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="157" mass="16779" checksum="3D4640B70D455917" modified="2015-07-22" version="1">MSTTPLPGIGVKYDLTTRAQKKHLSVIAHRDGTRSINVYRSDDPDACMQSLHLNGAETAALIDALTPSHHSPNLLHTTDLGLVAERVELSATSYWNGRVLGETRVRTETGASIVAVLRRAEAIPSPAPDFRFAGGDTLIVIGTREGIEAAAALLGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCK3</accession>
    <name>A0A0F7NCK3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_31105</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH85926">
        <property type="protein sequence ID" value="AKH85926"/>
        <property type="gene ID" value="AA958_31105"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_31105"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6573"/>
    <dbReference type="OrthoDB" id="643917at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH85926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="78" mass="8205" checksum="20113282B143446B" modified="2015-07-22" version="1">MLVVHDPTTAVDVVTEARIAEGLRDHRAGMTTLLVTNSPALLAVADRVVFVDAGRVAAEGPHADLVRDESAYRAAVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCQ4</accession>
    <name>A0A0F7NCQ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Threonine dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_26855</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018491.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_26855"/>
    <dbReference type="EnsemblBacteria" id="AKH85254">
        <property type="protein sequence ID" value="AKH85254"/>
        <property type="gene ID" value="AA958_26855"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_26855"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5649"/>
    <dbReference type="OrthoDB" id="1876944at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901607">
        <property type="term" value="P:alpha-amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PALP" evidence="3">
        <location>
            <begin position="21"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH85254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="317" mass="32683" checksum="4605F722E74BD91A" modified="2015-07-22" version="1">MRTPTVTDALLARRLVRDVLPPTPLWSYATLDRGPAAALFVKHENTQPTGAFKVRGGLALLASMTAEERARGIVGYSTGNHAQSLAYAAARHGAPCAIVMPERANPGKVRAVTALGAELIQHGATFDEARPYAAQVAAERGARLVSAADEPEIVAGVATAYLELFEQAPDLDTVIVPVGGGSGAAAACLTAAAVAPDCRVVAVQSAASPAAYESWRAGRLAERPNRTRVEGLATGTGFALPQALMRTGLADFLLVDDDAIALAQRSLMRDAHTLAEGAGAAALAALHTHPDAFAGQRVAVVCTGGNAQEEEIARAIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCS2</accession>
    <name>A0A0F7NCS2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_33250</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019510.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_33250"/>
    <dbReference type="EnsemblBacteria" id="AKH86285">
        <property type="protein sequence ID" value="AKH86285"/>
        <property type="gene ID" value="AA958_33250"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_33250"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.7023"/>
    <dbReference type="OrthoDB" id="447734at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519499" evidence="2">
        <location>
            <begin position="17"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH86285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="447" mass="48475" checksum="1EF03B8B0EAA5E19" modified="2015-07-22" version="1">MRPAVRIRHAATAAGAAALSLALLAGCSGDGGSDDGTVTLDYLSLAWQEESVAANKRLVEEWNEEHPDVQVRYVQGIWDTVHDQLLTSFEGGEAPDIIHNAADDLTDFAYGGYLADLTDLLPASVRADIPEQSWRTTTMNGGIYGVPFLQEPRMMFANTALLEESGVRVPTAADPWSWQEFEDAAEELTADTDGDGKTDQYGVAWGMKEPVSQSVNLSLSTGGGLFSREQTDDGPKNRVAYGPEDSAVAETIDRQVNEDRTAPRSSLGMSGSDTLPGFFAGRYAMVPLNFSYRQLVTQQAPDDFAWSVLPMPAGDGPAGGLAQGVSPQTLSVAEDSGHRQAAADFIAFMTRPEHMAELAAGDWMLPTGAEALKDPALNTEKYGWRTGVEVARSLRPAPVLGVRGYREWSDKIATPAFQRYFNGDTDLDELRESLVEDGNLVLDRYQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCS8</accession>
    <name>A0A0F7NCS8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">L-glyceraldehyde 3-phosphate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_22580</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the shaker potassium channel beta subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017780.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_22580"/>
    <dbReference type="EnsemblBacteria" id="AKH84522">
        <property type="protein sequence ID" value="AKH84522"/>
        <property type="gene ID" value="AA958_22580"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_22580"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4751"/>
    <dbReference type="OrthoDB" id="1351747at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005399">
        <property type="entry name" value="K_chnl_volt-dep_bsu_KCNAB-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43150">
        <property type="entry name" value="PTHR43150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="2">
        <location>
            <begin position="15"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH84522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="329" mass="36041" checksum="0DD44F7D4CE8988A" modified="2015-07-22" version="1">MTYRRTGRSGLKLPEISLGLWHNFGDDRSLESQRAILRRAFDLGVTHFDLANNYGPPPGSAEENFGRIFAADFRPYRDELVLSTKAGYLMQPGPYGEWGSRKYLLSSLDASLGRMGVDYVDIFYSHRYDPDTPLEETMGALASAVQQGKALYVGVSSYTAEQTREAARLLREMGVRPLIHQPSYSMINRWTEDDELLDTLEAEGMGCISFAPLAQGMLTDKYLDGIPADSRAAQNKSLDPELLTDEVVRRLRGLNEIARGRGQSLAQLALGWVLRDPRMTSALIGASSVAQLEANVAALGAAELTAAELAEIDGFAKTTSGVNIWAGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCV3</accession>
    <name>A0A0F7NCV3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Amino acid ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AA958_26570</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018440.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_26570"/>
    <dbReference type="EnsemblBacteria" id="AKH85203">
        <property type="protein sequence ID" value="AKH85203"/>
        <property type="gene ID" value="AA958_26570"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_26570"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5591"/>
    <dbReference type="OrthoDB" id="1523519at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010065">
        <property type="entry name" value="AA_ABC_transptr_permease_3TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043429">
        <property type="entry name" value="ArtM/GltK/GlnP/TcyL/YhdX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30614">
        <property type="entry name" value="PTHR30614"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01726">
        <property type="entry name" value="HEQRo_perm_3TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="238"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="8">
        <location>
            <begin position="68"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="293"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH85203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="328" mass="34427" checksum="888F86ED5A3CB780" modified="2015-07-22" version="1">MSSVLYDAPGPKAKRRNVVYTVVFLVVLALGVWWVIDKLNEKNQLEWVLWKPFFTDSQAWTTYLLPGLGETLKAAGLSLLIALPLGALFGIARLSDHAWVRVPAGAVVEFFRAIPVLLLMLFANQFYSEYTDISSDQRPLYAVVTGLVLYNSSVLAEIVRAGILSLPRGQTEAAKAIGLRKGQMMGSVLLPQAVTAMLPAIVSQLVVIVKDTALGGAMIGFSELLVERRTLASNYSNVFASFIVVAAIYVVVNFILTSLASWLEQVVRRGKRTTGAVVGATAIEDLSAGAAGGASGMAAGATGSAGPPGDGDPGGGGDGGDGGEGRLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCY1</accession>
    <name>A0A0F7NCY1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_31945</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019294.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86066">
        <property type="protein sequence ID" value="AKH86066"/>
        <property type="gene ID" value="AA958_31945"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_31945"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6746"/>
    <dbReference type="OrthoDB" id="2031675at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519506" evidence="2">
        <location>
            <begin position="35"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH86066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="180" mass="18869" checksum="669114D6C1B0578F" modified="2015-07-22" version="1">MFTTRKRAFAQTLLASSALVVSVVLAGCSDDSEAASSDGGTSASPGSPFDQAVEYAQCMRDNGVPEFKDPVQDTGGVMFNQGGFDPESAEFKAAEEACRDKQPQRQGGPNGGEPLDSEKVAEWAECIRQNGVPDFPDPEIEGNSMVVDIGAADPTTFEPARQACQDKYPGGGMRIGGGPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDW1</accession>
    <name>A0A0F7NDW1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FAD-linked oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_34035</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019643.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_34035"/>
    <dbReference type="EnsemblBacteria" id="AKH86421">
        <property type="protein sequence ID" value="AKH86421"/>
        <property type="gene ID" value="AA958_34035"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_34035"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.7191"/>
    <dbReference type="OrthoDB" id="1034540at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004017">
        <property type="entry name" value="Cys_rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-linked_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02754">
        <property type="entry name" value="CCG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13183">
        <property type="entry name" value="Fer4_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="SSF55103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="5">
        <location>
            <begin position="37"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="600"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH86421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="948" mass="101760" checksum="81008495B8C606DB" modified="2015-07-22" version="1">MIAVEELVTALRREVPSLRIDTTGGRRAQYAYDASNYRVPPLAVAFPVDADEVYGAHQVCHRLGVPVTTRGAGTSMAGNAVGTGLVLDLSRHMHRVLDIDASAQTARVEAGIVLDDLQNAAGAYGLVFGPDPSSHSRCTIGGMIANDACGNHSVRYGRTGEHLLTLDLVLADGTRVVADRDGLHAVDEAGRERVAELTSALRGIVDTNLAAIRLNLGRITRQVSGYQLQHLLPENGFDVVRVLAGTEGTCATVVSATVRLMPKPPTALLIALGYDDVVDAAEDVPLILKFSPAAVEGLDEAIVATMRHRRGASSVTRLPEGRAWLYVDLDGDDPRQVTAEAERLLDELKTAGRMVSGRLITDRAERASLWRVREDGAGLAARLTDGRASWPGWEDAAVAPGQLAAYLRDFRALMAEHRLTGVLYGHFGAGCVHARLDFRPDTDEGRAVMRAFLTDAARLVVRHGGTLSGEHGDGRARSELLSVMYDRPMLDAFAAFKHAWDPEGLLNPGILVDPRPLDADLALGTGRTTALSTVFAFLEDPDGITAAANRCVGVGRCRSHTGGVMCPSYRATGDEQHSTRGRARTLQEMLRGALPGGWRSRETREALDLCLSCKACSSDCPVGVDMATYKSEFLHHHYKWRPRPLSHYSLGWLPLWTALAGRMPRLVNAVMGSRFGPWIARLGGVTPKRSLPAFHGRRAWRRGVAETAQAPAAVLVVDSFTRAFRPELAGAASRVLADAGLPTQARGDVCCGLTWITTGQIGIARRMLARTAATLDATEGPIVVTEPSCAAALAKDLPELVDSDAARRVAVRVQTFTGALAERVAAGWKPRQVPDEVVLQTHCHQYAVFGAGQQRDLLRDLGVEKVTEATGCCGAAGNFGFENEHYDVSVAVADQALRPRLEAAALETPVLADGFSCQMQIEHLVGDDRPGATHLAQLLDDPQSPSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NE02</accession>
    <name>A0A0F7NE02_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Usp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_29125</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018862.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_29125"/>
    <dbReference type="EnsemblBacteria" id="AKH85633">
        <property type="protein sequence ID" value="AKH85633"/>
        <property type="gene ID" value="AA958_29125"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_29125"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6138"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="3">
        <location>
            <begin position="4"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="173"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH85633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="252" mass="26013" checksum="97EB49933B83EA30" modified="2015-07-22" version="1">MTMERVLVGFDGSVPAVRALDLAAEEAALRGGELEIVHALPDVDGAAPVLAAAVDRVHTRHPALETAAVPVAGDPVRALLDRGRTAALTVVGSRDLDGIAGFVTGSVSRRTAARAECPVMIVGGKRAGRRQAGPGFVLFVVGADDEADAAGLAFAEARLRGVELRIRHAPTYAPAAPGPAAARRHPAAPEPHQRAPQHRETRAALATSAAGAAETGEALLVVATRRSCRGPDRAARSLLHEARCPVVLVPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NE49</accession>
    <name>A0A0F7NE49_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9 10">Endo-1,4-beta-xylanase</fullName>
            <ecNumber evidence="3 9 10">3.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">AA958_29830</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9 10">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-xylosidic linkages in xylans.</text>
            <dbReference type="EC" id="3.2.1.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9 10">Glycan degradation; xylan degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the glycosyl hydrolase 11 (cellulase G) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.8" evidence="3 9 10"/>
    <dbReference type="EMBL" id="CP011492">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_29830"/>
    <dbReference type="EnsemblBacteria" id="AKH85729">
        <property type="protein sequence ID" value="AKH85729"/>
        <property type="gene ID" value="AA958_29830"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_29830"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6299"/>
    <dbReference type="OrthoDB" id="1121261at2"/>
    <dbReference type="UniPathway" id="UPA00114"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031176">
        <property type="term" value="F:endo-1,4-beta-xylanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030247">
        <property type="term" value="F:polysaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001919">
        <property type="entry name" value="CBD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008965">
        <property type="entry name" value="CBM2/CBM3_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012291">
        <property type="entry name" value="CBM2_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013319">
        <property type="entry name" value="GH11/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018208">
        <property type="entry name" value="GH11_AS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033119">
        <property type="entry name" value="GH11_AS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033123">
        <property type="entry name" value="GH11_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001137">
        <property type="entry name" value="Glyco_hydro_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00457">
        <property type="entry name" value="Glyco_hydro_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00911">
        <property type="entry name" value="GLHYDRLASE11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00637">
        <property type="entry name" value="CBD_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49384">
        <property type="entry name" value="SSF49384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51173">
        <property type="entry name" value="CBM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00776">
        <property type="entry name" value="GH11_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00777">
        <property type="entry name" value="GH11_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51761">
        <property type="entry name" value="GH11_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7 9 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 9 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9 10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9 10" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519348" description="Endo-1,4-beta-xylanase" evidence="11">
        <location>
            <begin position="40"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="GH11" evidence="13">
        <location>
            <begin position="41"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="CBM2" evidence="12">
        <location>
            <begin position="234"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9">
        <location>
            <position position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AKH85729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="325" mass="35005" checksum="AF6F0C31F3F94143" modified="2015-07-22" version="1">MDTHHDPARSLSRRRFVVGGAGALAVAASPLLLPGTAHAQTVTTNQTGTHNGYYFSFWTDAQNTVSMTMGSGGQYSTSWRNTGNFVCGKGWSNGSRRNVNYSGSFSPSGNGYLCLYGWTSNPLVEYYIVDNYGTYRPTGENHGSVTSDGVTYDIYRTMRYNAPSVEGNQTFPQYWSVNRGRRTGGTINTGNHFDAWSRAGMNLGSFNYYMIMATEGYQSSGSSNITLDGTGGGDPGEPGGCTATLSAGERWSDRYNLNVATSGSSNWSVRMNVPSPAKIIATWNISASYPDSQTLVARPNGSGNNWGVTIQANGNWNWPTVSCSA</sequence>
</entry>
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    <accession>A0A0F7NE68</accession>
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        <submittedName>
            <fullName evidence="3">Recombinase RecB</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="3 4">
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AKH86536">
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    </dbReference>
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    <dbReference type="PATRIC" id="fig|444103.5.peg.846"/>
    <dbReference type="OrthoDB" id="1283891at2"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH86536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="302" mass="33086" checksum="00BB72129EC060FA" modified="2015-07-22" version="1">MSPSRAADFMTCPLMYRFRVIDRLPEKPRASAARGTLVHAVLERLFDDPAAERTPPRARALVAPAWERLLADRPELAELFTDGDEDGAGSTGGGGDGPSAGAAERLAEWLAGAERLVERWFTLEDPARLEPAERELFVETVLASGLKLRGVIDRVDVAPTGEVRVVDYKTGKAPPPEYAADALFQIKFYALVLWRLRGSVPRRLQLVYLGSGDVLTYDPDEADLRGVERKVHALWEAIRRATESGDWRPRPGRLCDWCDFKDSCPAFGGTPPPYPLTGVDPGLPQPRPAGAGEDAQGRMDTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NED1</accession>
    <name>A0A0F7NED1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">YcaO domain-containing protein</fullName>
        </recommendedName>
    </protein>
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    </gene>
    <organism evidence="2 3">
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        <lineage>
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        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_08710"/>
    <dbReference type="EnsemblBacteria" id="AKH86621">
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        <property type="gene ID" value="AA958_08710"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_08710"/>
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    <dbReference type="Proteomes" id="UP000034283">
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="11"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="380" mass="41951" checksum="A00268EE8AA904B8" modified="2015-07-22" version="1">MDRADEFSGSGRAVDRPELARLTAIAEAAERYAGADFPDGPDVLARAAELDGPVIDLAALPACSTREYESGRCPLTRYRPEALIRWLRGFELTSREDRWVPAVMARYGGPVRDSENFWYRISTGYAVHTDPVEAVFRGLCEVAERDAAALTWLQQLPLHPIRFPAPAGELAAVLEMCDRQFIETHFFDATTDVGVPTVCCLQLAEYDERCAQSMTVATGRSLAEAAAKSLLEAVTGRALHHRPNREDHRTVMAGADEMGMRERRAAFGFLLPERNGGPARRPRLPDARPALAPDAREALGDLVEGFTARGQQVVAVDRTTSELQEAGLTAVCVIVPALQPLTFHRYAQYRAHPRLYAAPEPMGFPSRPEEELNAWPVPYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NEI7</accession>
    <name>A0A0F7NEI7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SAM-dependent methlyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_30630</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019077.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH85849">
        <property type="protein sequence ID" value="AKH85849"/>
        <property type="gene ID" value="AA958_30630"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_30630"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6473"/>
    <dbReference type="OrthoDB" id="1687413at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="2">
        <location>
            <begin position="64"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH85849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="260" mass="28581" checksum="B2BC6E7A5237B469" modified="2015-07-22" version="1">MTSPNEHGGPGGRNRRERSERERRERSRQAGSFGGAAGAYERGRPPYPPEATAWLVPESARAVVDLGAGTGKLTRALRAPGRELVAVEPSAGMREEFARVVPGIRALAGTAESIPLPDASADTVVCAQAWHWADPERAVPEVARLLRPGGRLALVWNNRDESVPWVAELGRLLREYAPAPAEDRQTDRIGAPFGPVERRDFRWRHPVTEAEIVDMIASRSYVITLAPAVRDRLLDRVRALLAVARPGEMPYVTECHRAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NEM7</accession>
    <name>A0A0F7NEM7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_30895</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019117.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH85889">
        <property type="protein sequence ID" value="AKH85889"/>
        <property type="gene ID" value="AA958_30895"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_30895"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6529"/>
    <dbReference type="OrthoDB" id="1121832at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="281"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="337"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="376"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="403"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="21"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="220"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH85889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="429" mass="40801" checksum="41F0F0D088624300" modified="2015-07-22" version="1">MTTTAPAGPAVRTRARAQRRALTVLFAAQVLSGAGLAAGVVNGALLAQDMLGSTSLAGLLGALATAGAALAAAVVGRLSDAYGRRPGLAAGYLAGAVGSAGAVAAAVAGSSALLFAAMVVYGAGTATNLQARYAGADLAAPAYRGRAVSTVLVATTLGGVAGPNLAVPAGDLGAALGVPRLSGLFLVSAAAYGAAALVLAVWLRPDPLLLARELDAAEGSAAPPAAEPGAAIGAEPGAKPPAGRRGPGVLPGALVMVVTQLVMVAIMTMTPVHMHDNGHGTAASGLVIAVHIGAMYLPAPLSGWLVDRRGPLVVAVAAGLAMLAAGVVAATTAESTAVFAVALALLGVGWSLGLVSGTAMVTSAIPPATRARTQGLVDVAISAAGAGGGLASGAVVAGAGYPLLTVGGGILALAVVPAAVAAAGGISRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NF59</accession>
    <name>A0A0F7NF59_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_31390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019201.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_31390"/>
    <dbReference type="EnsemblBacteria" id="AKH85973">
        <property type="protein sequence ID" value="AKH85973"/>
        <property type="gene ID" value="AA958_31390"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_31390"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6633"/>
    <dbReference type="OrthoDB" id="70058at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004573">
        <property type="term" value="F:Glc3Man9GlcNAc2 oligosaccharide glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009311">
        <property type="term" value="P:oligosaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004888">
        <property type="entry name" value="Glycoside_hydrolase_63"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412">
        <property type="entry name" value="PTHR10412"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="484" mass="50973" checksum="8D9534F94F55A623" modified="2015-07-22" version="1">MTAAPAEERGATALTAAPGDGTDAGASGPVRADDPWRAAAAVLLGNWTGTSTVPSRTLYPHQWSWDSAFVAIGLRHLSPRRAQRELEMLLGAQWGDGRIPHIVFNPAVPHAAYFPGPEFWRSAGSPAGGGGGVAGPGAGARAGAPARTQTSGIVQPPVHALAALLVHRADPAASARRGFLARVYPRLLAWHRYLTEDRDLGGAGLAAIVHPWESGMDNSPCWDGPLARIEPAPAASFRRADLDHGDPADRPTDLDYGRYVRLAADYRDAGYADAGVRHGFAVEDPCVNALLIASEEAMAEIAAELGADPGGHRERAARLTEALVARLWNPDAGIFRSRDLRAGRAIGEYSVAGLTPLLAPGLPPAVARTLRETLAGPHFRLGELPLVASYDLEGRAFDRTRYWRGPAWFNTAWLLERGLRGHGAAATADALRRAVLSGAAASGFAEYVDPLTGAGRGARGFSWTAALALDLASSGREWPGAGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NF63</accession>
    <name>A0A0F7NF63_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_31415</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019206.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_31415"/>
    <dbReference type="EnsemblBacteria" id="AKH85978">
        <property type="protein sequence ID" value="AKH85978"/>
        <property type="gene ID" value="AA958_31415"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_31415"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6638"/>
    <dbReference type="OrthoDB" id="1510342at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="197"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="81"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH85978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="288" mass="31080" checksum="415F9957FAAC3ED4" modified="2015-07-22" version="1">MTRAQFEDRLFGTLRWVVIAFLALITVVPFYYMVVLSLKPVDSLLADPGSMWVSAKELTTTTYRDVLKPTEDGGQGFLKLMLNSALVSLGTVVLTLAAAVPGSYAVSRLRFFGSRQVSAMFLAVYLFPATLLAVPLFVMFARMGLSGSLVGLAIVYVAQTVPVSIYMLKNYLVTIPPSIEEAASLDGCGRLQTLRKVVLPLAAPSLMATGLYVFMIAWNEFLFALLFLAAEPESWTVSLGLAQLSNGIEVSKTVLMAGSVVLTIPVVLLFFAAERLLTEGLTSGADKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NF89</accession>
    <name>A0A0F7NF89_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Deaminase/reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_27505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018591.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_27505"/>
    <dbReference type="EnsemblBacteria" id="AKH85357">
        <property type="protein sequence ID" value="AKH85357"/>
        <property type="gene ID" value="AA958_27505"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_27505"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5795"/>
    <dbReference type="OrthoDB" id="1920912at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RibD_C" evidence="1">
        <location>
            <begin position="2"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="190" mass="20815" checksum="703DBBD2029D4E9D" modified="2015-07-22" version="1">MRTLISTAFVSLDGVMEAPGGEPGYRNSGWTFKETEFLPEAYALKGEEQEEAGALMMGRVSYEAFSPVWPGMEEFARYKVLPKYVVSTTLAEDDLVTDWGDITILRSLDDVAALKETEGAPIIVHGSATLNHGLADAGLIDRYHLLVFPLLLGAGKRLYSDTSKDTQKLKLVAAEAYANGIQKNVFDVLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFI4</accession>
    <name>A0A0F7NFI4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Enoyl-CoA hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_32120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019326.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_32120"/>
    <dbReference type="EnsemblBacteria" id="AKH86098">
        <property type="protein sequence ID" value="AKH86098"/>
        <property type="gene ID" value="AA958_32120"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_32120"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6782"/>
    <dbReference type="OrthoDB" id="1498685at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="263" mass="26565" checksum="0A5C1194C5689E81" modified="2015-07-22" version="1">MSEGELRCGVDGGVATVVISNPAKRNAMTPDMWRALPGLLAGLATDRAVRAVVLTGAGGTFCAGADIGSLRTGSEGTQGLAEAAEESLAAFPKPTLAAVRGHCVGGGCQLAAACDLRFAAEDALFGVTPAKLGIVYPAGATRRLVRLVGPATAKYLLFSAELIGAARALRTGLADEVLPAAELGARVAEFTAVLAARSQLTQAAAKDFADTAGAYGDGGAAGDAGADAARIAHWARQARAAGDTAEGVAAFLERREPRFTWSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NGY5</accession>
    <name>A0A0F7NGY5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_05245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_026276177.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_05245"/>
    <dbReference type="EnsemblBacteria" id="AKH86558">
        <property type="protein sequence ID" value="AKH86558"/>
        <property type="gene ID" value="AA958_05245"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_05245"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1101"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045745">
        <property type="entry name" value="HTH_58_Actinobacteria-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19575">
        <property type="entry name" value="HTH_58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_58" evidence="1">
        <location>
            <begin position="4"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="72" mass="7615" checksum="F9EA61B473D56916" modified="2015-07-22" version="1">MAETLKKGSRVTGAAREKLAADLKKKYDSGASIRALAEETGRSYGFVHRMLSESGVTLRGRGGATRGKKASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NIE4</accession>
    <name>A0A0F7NIE4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_04175</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_026276372.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_04175"/>
    <dbReference type="EnsemblBacteria" id="AKH86537">
        <property type="protein sequence ID" value="AKH86537"/>
        <property type="gene ID" value="AA958_04175"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_04175"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.876"/>
    <dbReference type="OrthoDB" id="2084431at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043758">
        <property type="entry name" value="DUF5703"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18963">
        <property type="entry name" value="DUF5703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH86537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="62" mass="7539" checksum="C27F3D5D60C1BF01" modified="2015-07-22" version="1">MPEYEFRDVYVPRGVSRAAAARLLTDQAEYGHWELHRLRLYPDGSRRARLRRRIIRQVRATW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NIP0</accession>
    <name>A0A0F7NIP0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Deaminase/reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_30545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020572.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_30545"/>
    <dbReference type="EnsemblBacteria" id="AKH87148">
        <property type="protein sequence ID" value="AKH87148"/>
        <property type="gene ID" value="AA958_30545"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_30545"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6455"/>
    <dbReference type="OrthoDB" id="1920912at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RibD_C" evidence="1">
        <location>
            <begin position="3"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH87148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="208" mass="22487" checksum="BC52061845136E51" modified="2015-07-22" version="1">MKLTTVTNVSVDGVMQGLGRADEDRRDGFERGGWALPLFGQEAEAYLGEVYQRADAFLFGRWTYEVFAGSWGVLPDPEDNPIGGPLNRQPKYVVSNTLDEPRWAGTRVLSGDPVSAVRELKAGADGEVQVHGSGKLLRCLLANGLVDEITLLTYPVVVGQGRRLFPSDGPDAALDLLDYRAFPGGITAHVYRPAGRPEYAGEDVGPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NK40</accession>
    <name>A0A0F7NK40_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_31005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020589.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH87162">
        <property type="protein sequence ID" value="AKH87162"/>
        <property type="gene ID" value="AA958_31005"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_31005"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6552"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH87162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="232" mass="23127" checksum="7D0B37B00CBABBE6" modified="2015-07-22" version="1">MPGASDTENEALRRVLRGAWPSLPALAVAGAAVCAAGTLAVLLAPGVTPVSVLVAAVLTGPWLAALGAAADRIAAAGEAGIRDWWRGLRALWRFGPAQALVPAVPAAAFLATLDLWQQTRGPWLLPSLAAGGACAVAGLLALPAALSLGAARPGLRGRLLWICAVHLVARHPTRFLAAPSLALLGLAASLRWTASLLLLVPPLVALVAAAATATALVRHGAAGAGGGEPGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A097H0Y5</accession>
    <name>A0A097H0Y5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Deaminase/reductase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Putative deaminase reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cnq744</name>
        <name evidence="3" type="ORF">AA958_30710</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="ChemBioChem" volume="15" first="2385" last="2392">
            <title>A Membrane-Bound Prenyltransferase Catalyzes the O-Prenylation of 1,6-Dihydroxyphenazine in the Marine Bacterium Streptomyces sp. CNQ-509.</title>
            <authorList>
                <person name="Zeyhle P."/>
                <person name="Bauer J.S."/>
                <person name="Steimle M."/>
                <person name="Leipoldt F."/>
                <person name="Rosch M."/>
                <person name="Kalinowski J."/>
                <person name="Gross H."/>
                <person name="Heide L."/>
            </authorList>
            <dbReference type="PubMed" id="25224759"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CNQ-509</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KJ451627">
        <property type="protein sequence ID" value="AIT42132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019090.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_30710"/>
    <dbReference type="EnsemblBacteria" id="AKH85862">
        <property type="protein sequence ID" value="AKH85862"/>
        <property type="gene ID" value="AA958_30710"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_30710"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6490"/>
    <dbReference type="OrthoDB" id="1306955at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RibD_C" evidence="1">
        <location>
            <begin position="6"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIT42132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH85862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="192" mass="20979" checksum="A823E5B711F47F90" modified="2015-01-07" version="1">MTATYTFDVFSSLDGYGAAGGDWTGYWGKQGPELLDRRLGLYSEEQRMVFGAHTHRLFAQMVADSSEGDDVRDPWVTRMTQLPATVVSTTLAESLDWPDATVARGDAVDVVARMKEESDVPLRSHGSLSMNRALMAAGLVDLVHVTLFPVITGRSGLAPIFEGAADFDLDLIETRTLDGSIQELIYRPTLHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MXR8</accession>
    <name>A0A0F7MXR8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Amino acid ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_01400</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014405.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_01400"/>
    <dbReference type="EnsemblBacteria" id="AKH81040">
        <property type="protein sequence ID" value="AKH81040"/>
        <property type="gene ID" value="AA958_01400"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_01400"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.309"/>
    <dbReference type="OrthoDB" id="1179151at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032823">
        <property type="entry name" value="BCA_ABC_TP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12399">
        <property type="entry name" value="BCA_ABC_TP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="20"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="52"/>
            <end position="59"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH81040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="264" mass="28041" checksum="B7C511475B3BFE12" modified="2015-07-22" version="1">MTSTTRTTSGDTTALPRAILSTRGLTKAFQGFRAVDGVDLDVAEGTVHALVGPNGAGKTTLFNLLTGFLPPSAGRIELAGQDITGLPPERVARLGVARSFQVTSLFPGVTARAHLELALQAGTDLGRRFWRSDKLLARFTERARELLDQVGLAERAESPAGSLPYGQKRALELALALALDPRVLLLDEPTAGMGLEDVDRTVALVDRIRAGRTVVLVEHNMSVVGSLADTVTVLQHGRVLVEGAYRTVRSDPRVVEAYLGAGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MXU5</accession>
    <name>A0A0F7MXU5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Mannose-1-phosphate guanyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_01575</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014434.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_01575"/>
    <dbReference type="EnsemblBacteria" id="AKH81070">
        <property type="protein sequence ID" value="AKH81070"/>
        <property type="gene ID" value="AA958_01575"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_01575"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.346"/>
    <dbReference type="OrthoDB" id="1557977at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016868">
        <property type="term" value="F:intramolecular transferase activity, phosphotransferases"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="SSF55957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="2">
        <location>
            <begin position="2"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_I" evidence="3">
        <location>
            <begin position="384"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_II" evidence="4">
        <location>
            <begin position="532"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_III" evidence="5">
        <location>
            <begin position="639"/>
            <end position="746"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH81070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="831" mass="89625" checksum="65703C92FAC88537" modified="2015-07-22" version="1">MKAVVMAGGEGTRLRPMTASMPKPLLPVVNRPIMEHVLRLLKRHGLTETVVTVQFLASLVRNYFGDGEELGMELTYANEDRPLGTAGSVKNAEEALKDDSFLVISGDALTDFDLTDLIAFHREKGALVTVCLTRVPNPLEFGITIVDEEGKVERFLEKPTWGQVFSDTVNTGIYVMEPEVFDYVEADTSVDWSGDVFPQLMKDGKPIYGYVAEGYWEDVGTHESYVKAQADVLEGKVDLDLDGFEISPGVWVAEGAEVHPEAVLRGPLYIGDYAKVEQGAEVREHSVLGSNVVVKQGAFLHRAVVHDNVYIGGHTNLRGCVIGKNTDVMRAARIEDGAVIGDECLIGEESIIQGNVRVYPFKTIEAGAFVNTSVIWESRGQAHLFGARGVSGILNVEITPELAVRLAGAYATTLKKGSSVTTARDHSRGARALKRAVISALQASAIDVRDLENVPLPVARQQTARGSAGGIMIRTTPGVQDSVDIMFLDERGADLSQAAQRKLDRVYARQEYRRAFPGEIGDLSFPASVFDSYTGSLLRAVDTAGIAEAGLKVVVDASHGSAGLVLPSLLGRLGVDALTINPGLDESRPTETPQSRRAGLVRLGEIVSSARAAFGVRFDPVGERISLVDEKGRIVEDDRALLVMLDLVAAERRSGRVALPVTTTRIAEQVAAYHGTQVEWTTTSPDDLARVARMDDAVFGGDGRGGFIIPEFSSVFDGAAAFARLTGLVARTQLTLSQIDARIPQAYVLCRDLATPWAVKGMVMRRVVEAAGSREVDTTDGVRVVEPDGRWVLVLPDRAEAVTHLWAEGPDQASAEALLDEWAAVVDGSGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MXW3</accession>
    <name>A0A0F7MXW3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_01660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014449.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_01660"/>
    <dbReference type="EnsemblBacteria" id="AKH81085">
        <property type="protein sequence ID" value="AKH81085"/>
        <property type="gene ID" value="AA958_01660"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_01660"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.364"/>
    <dbReference type="OrthoDB" id="516748at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="505" mass="54443" checksum="CB1FC480D80EB0DE" modified="2015-07-22" version="1">MTAPTTATPAPGAPRPAPGPAADEGLARRLRALACTAPLHDLDARKAMLAGEFGVYAMAEVALSAIDLITLQMDFDTGAEPDEVIARLLPRVAAQAPLRPRAEHERVAHWVLDSLVNVGSVDRGFRAVYGTFGHDGAYVRREYDFKLLEEVPGPGGAVYLRTTDEAVNVLVGALDTDVTSAQIAAEVKLEVLISRGRLADAQLAAEQARYRTVQYAETLRRALEATRRNVRAVDWLQTVPAMIDEALDHVADRYRHENAILTNIRRARDEAEDPDHKRRAAELVDIVKDCIRRHTQLQTRLLDAGPLFRAEQDRQAFAPPAARTGVDLYGQLLAPVLPLPVSAAHRVTDAFFARGTGLRAPHAVRLADLAELLLTPPLERAHLGAAMPEPDLVATPDDSRFSEEQLAAAGELLDLPPDAPRRLSGLLADARRRDPELPYLVALLAVHAAGPAVGTAYRQGDERLLFAVDDGTQMEDAEFGGADLIVGTALLDAAGMAAGRTEAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MY41</accession>
    <name>A0A0F7MY41_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_02095</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014524.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_02095"/>
    <dbReference type="EnsemblBacteria" id="AKH81160">
        <property type="protein sequence ID" value="AKH81160"/>
        <property type="gene ID" value="AA958_02095"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_02095"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.451"/>
    <dbReference type="OrthoDB" id="1437290at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="14"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH81160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="213" mass="23835" checksum="56A37C73A672FF51" modified="2015-07-22" version="1">MSPRRPAVNEELRRRSRERLLQATVELVDERGFEGTTLGDIAERAGSARGLVSYYFPGKRQLVQSAVHRLMHLTLGAALERPSHTEDGQERMARAIDAILGLSQDHPVLMRHHMAGILQADGFIQCAEQQQLAVLLRDTVACWGSPHPDTEYPMLRAQLMGAVFALLLPGVPMPLDRLRGELFRRYGLDWHLGVPPEGVQPFDGTPVRAAHRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MZ43</accession>
    <name>A0A0F7MZ43_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_04405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014910.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_04405"/>
    <dbReference type="EnsemblBacteria" id="AKH81555">
        <property type="protein sequence ID" value="AKH81555"/>
        <property type="gene ID" value="AA958_04405"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_04405"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.928"/>
    <dbReference type="OrthoDB" id="1515497at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="60"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="242" mass="26621" checksum="4B731565240C703F" modified="2015-07-22" version="1">MFSPEGPTLLELTVQAMSSTERGYDLLAPKFDSSPFRTPDRVLDAFAAAVEPLGPFVHGLDVCTGTGAGAGTLRRLCKERVVGVDFSAGMLAEARRAYADAADPPSMRWVRADTLALPFAPAFDLAVSFGAFGHFLPRERPALFSQVFRSLRPGGYFAFPVPAPQPVGSRGYWALWGFDTAMRVRNALWRPRFVMYYRTFRLPDVLADLERTGFTVATAALEDLGRRPDGSPRARAVFARRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MZ65</accession>
    <name>A0A0F7MZ65_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_04540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014935.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_04540"/>
    <dbReference type="EnsemblBacteria" id="AKH81580">
        <property type="protein sequence ID" value="AKH81580"/>
        <property type="gene ID" value="AA958_04540"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_04540"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.957"/>
    <dbReference type="OrthoDB" id="1356861at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH81580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="253" mass="25885" checksum="7D5CE6092A32BBCB" modified="2015-07-22" version="1">MGSVRDARAVVTGGAAGIGAALARRLAAEGARVAVNDLDEAGARAVAAEIGGVALPGDASDAVPAARAALGGIDLFCANAGLATGGGPETPDDEWSAAWDVNVMAHVRAARQLVPEWLERGGGRFVATVSAAGLLSMVAAAPYAVTKHAALAFAEWLSLTYRHRGISVHAVCPQGVRTDMLRATGAAGDLVLAPGAIEPEQVADAVLAGIAEDRFLILPHPEVAGYSALRATDPDRWLSGMNKLQRTLEEGRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MZR8</accession>
    <name>A0A0F7MZR8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Multidrug ABC transporter ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AA958_02305</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014560.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_02305"/>
    <dbReference type="EnsemblBacteria" id="AKH81196">
        <property type="protein sequence ID" value="AKH81196"/>
        <property type="gene ID" value="AA958_02305"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_02305"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.494"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="72"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="263"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="37"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="357"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="390"/>
            <end position="397"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AKH81196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="614" mass="65488" checksum="31F682416E441EF0" modified="2015-07-22" version="1">MPHDPLDGWSPPPSDPEQPAQVRRILALFRPYRGRLAVVGLLVAASSLVSVASPFLLREVVDTALPEGRTGLLSLLALGMVGVAVLGGVFGVLQTLISTTVGQRVMHDLRTAVYAQLQRMPLAFFTRTRTGEVQSRIANDIGGMQATVTTTATSLVSNLTSVIATVVAMLALDWRLTVVSLLLLPLFVWIARRVGRERKKITSQRQKQMAAMAAGVTESLSVSGIMLGRTMGRSDSLTRGFADESESLVDLEVRANMAGRWRMATIGVVMAAMPAVIYWTAGLASGTGGQAVSIGTVVAFVSLQQGLFRPTVSLLSTGVQMQTSLALFQRIFEYLDLPVDIAEPEHPVRLVKPRGEVRFEKVDFAYEAGQPTLRDVDLTVPAGSSLAIVGPTGAGKSTLGYLVPRLYDVTGGRVTLDGTDVRDLDFDSLARAVGVVAQETYLFHASVADNLRFARPDATDAEIEAAARAAQIHDHIAALPDGYDTLVGERGYRFSGGEKQRLALARTILRDPPVLVLDEATSALDTRTERAVQEAVDALAAGRTTITIAHRLSTVRDADQIAVLHDGRIAELGTHEKLMAAGGRYAALVRRDLDADASAVAGGEPVAKGASVTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MZX5</accession>
    <name>A0A0F7MZX5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pyrimidine reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_02665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014619.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_02665"/>
    <dbReference type="EnsemblBacteria" id="AKH81256">
        <property type="protein sequence ID" value="AKH81256"/>
        <property type="gene ID" value="AA958_02665"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_02665"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.569"/>
    <dbReference type="OrthoDB" id="1920912at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RibD_C" evidence="1">
        <location>
            <begin position="2"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="183" mass="19954" checksum="ADB6DEFFBEFCF600" modified="2015-07-22" version="1">MRKIVASLFISLDGVVEAPDQWHMSYFDDEMGEAVGGLMSDTMLYGRKTYESFAEAWPQREGTDDEDAGFAKILGDARKIVVSRGEVDLSWRNSEKLQGDLVTGVTALKKEPGGNVSIGGSVSVIRELLAHGLLDELHLLVHPVAVRQGERLFDEGGTRIPLKLLDSRAFASGVLHLVYGPAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N097</accession>
    <name>A0A0F7N097_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_07180</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="2"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015390.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_07180"/>
    <dbReference type="EnsemblBacteria" id="AKH82040">
        <property type="protein sequence ID" value="AKH82040"/>
        <property type="gene ID" value="AA958_07180"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_07180"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1504"/>
    <dbReference type="OrthoDB" id="114076at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="6">
        <location>
            <begin position="189"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="210"/>
            <end position="217"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH82040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="688" mass="73532" checksum="C2C38ED8322EE3AD" modified="2015-07-22" version="1">MGTAHPLAATSLADERRYHETCRAALDAMRAGADRQVVIGEHASASGADAEVLGYELRSQAKDLHELPPGPLFFGRLDFADDAGQAGGHAGQRYHIGRMRITEDPSAPPLVVDWRAPVSRAFYQAGPEDPQGVEIRRRFGWAPGATGDSDELTGLEDERPAAETTRGGRILAGEIERPRTGPMRDIAATIQPDQDDLVRRELGVSVCVQGAPGTGKTAVGLHRAAYLLYTYARQIRRGGLLVLGPNRTFLSYISAVLPALGETGVRQSTVGELVAGERQVHAEDGAAAAALKHDVRMAEVLRRALYARVSADGITEGVAVRDDSAWWRVPPAELGEIVAGVRDERLPYAIGRERVRSRIVDRIQRQAERRAVTPTAAWQQRVGRARSIGAFLDAAWPKVKPAEVLAALFTDAGELARAAHGVLDAGEQRALLWAKPPRSFKSAKWTAADHVLLDELSGLLDRPEGYGHIVVDEAQDLSPMEARVIARRAEFGSLTVLGDLAQGTTPWAARDWPSLLAHLGRPDAEIATLTTGFRVPAAVVDLANRLLGHLDVDVPAARSLRQDGALRILPTQDVLAATRDAVRQALSSEGSIGVVAAAADVDRVRAVLEEAGIATAGPDDLAARVTVLPATAAKGLEYDHVVAVEPAAITGAEGGPTGLRRLYVVLTRAVSRLDVVHSRPLPFPAKAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N099</accession>
    <name>A0A0F7N099_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_00160</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH80843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014210.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH80843">
        <property type="protein sequence ID" value="AKH80843"/>
        <property type="gene ID" value="AA958_00160"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_00160"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.36"/>
    <dbReference type="OrthoDB" id="1363223at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0814">Transposable element</keyword>
    <feature type="domain" description="DDE_3" evidence="2">
        <location>
            <begin position="174"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH80843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="362" mass="41667" checksum="C93C811DFB3E83A0" modified="2015-07-22" version="1">MPGPKPLPVVLSDEELRVLRCWLRKQTAAQALVLRSRIVLACAEGLSNAQVAEDLRISRETVRKWRARFVKDRLEGLTDRPRPGPPRRITDEQVEALVTKTLDEKPSSGDSHWSTRSMAEATGMSQSAVSRIWRAFGLKPHTMETWKLSTDPEFVTKVRDVVGIYLCPPENALVLAVDEKSQIQALDRTQPVLPMAPTTPARMPHDYVRHGTTSLFAALDIASGSVIAQHYRRHRHTEFLRFLKTIDAAVPKDLDLHLVLDNYATHKTEAVKKWLLRHPRFHLHFTPTSASWLNLVERWFAELTRRKLRRSAHRSVIELERDIRGWINEWNKNPKPFVWTKTADEILENLAAYCQRTNDSRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0K7</accession>
    <name>A0A0F7N0K7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoglycerate mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_04140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014871.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_04140"/>
    <dbReference type="EnsemblBacteria" id="AKH81516">
        <property type="protein sequence ID" value="AKH81516"/>
        <property type="gene ID" value="AA958_04140"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_04140"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.869"/>
    <dbReference type="OrthoDB" id="1122642at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022492">
        <property type="entry name" value="Phosphomutase_MSMEG4193_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03848">
        <property type="entry name" value="MSMEG_4193"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="241" mass="24854" checksum="E683B2C3D5503549" modified="2015-07-22" version="1">MPTLLLLRHARSTANVDGVLAGRGPGVGLDERGTAQAAALPARLAALTPAAVVTSPLERCRETLKPLLAARPELPVHVDERLTECDYGEWTGGKLAELADDPLMATVQQHPSAAVFPGGETMRAMQARAVEAVRDWNATVLAEHGPEALYVMCSHGDVIKSVVADALGMHLDLFQRIAVGPASVTAIRYTPLRPFVLRLGDTGSLDGLAPPPPAAEPGAEGAREDAADASAAEVGGGAGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0K9</accession>
    <name>A0A0F7N0K9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_00400</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asparaginase 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH80879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014245.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_00400"/>
    <dbReference type="EnsemblBacteria" id="AKH80879">
        <property type="protein sequence ID" value="AKH80879"/>
        <property type="gene ID" value="AA958_00400"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_00400"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.95"/>
    <dbReference type="OrthoDB" id="1659551at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004067">
        <property type="term" value="F:asparaginase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036152">
        <property type="entry name" value="Asp/glu_Ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006034">
        <property type="entry name" value="Asparaginase/glutaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020827">
        <property type="entry name" value="Asparaginase/glutaminase_AS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027475">
        <property type="entry name" value="Asparaginase/glutaminase_AS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040919">
        <property type="entry name" value="Asparaginase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027473">
        <property type="entry name" value="L-asparaginase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027474">
        <property type="entry name" value="L-asparaginase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037152">
        <property type="entry name" value="L-asparaginase_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00710">
        <property type="entry name" value="Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17763">
        <property type="entry name" value="Asparaginase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001220">
        <property type="entry name" value="L-ASNase_gatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00139">
        <property type="entry name" value="ASNGLNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00870">
        <property type="entry name" value="Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53774">
        <property type="entry name" value="SSF53774"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00144">
        <property type="entry name" value="ASN_GLN_ASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00917">
        <property type="entry name" value="ASN_GLN_ASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51732">
        <property type="entry name" value="ASN_GLN_ASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Asparaginase" evidence="5">
        <location>
            <begin position="7"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="Asparaginase_C" evidence="6">
        <location>
            <begin position="210"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="15"/>
        </location>
    </feature>
    <feature type="active site" description="O-isoaspartyl threonine intermediate" evidence="2">
        <location>
            <position position="15"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001220-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH80879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="327" mass="33186" checksum="88424EF562020630" modified="2015-07-22" version="1">MREPTTIAVLATGGTISAVADARRRHGGGLSATDLVAGHGSSGTRLRPIEVHRIPGRAMTPPHMLTLAQQVGQAAAACDGIVVLHGTDTLEETAYALAVMVDVPVPVVVTGAMRLPAQPGDDGPGNLAAAIAAARDPKLADSGPVVVFGDEVHLARWVTKAHTSRPAAFTSPDGGPAGQIHEGRLLLHRTAHRDSDHLGMPEPGRLADTRVPLVTVYAGIDGETVERAADGAAGLLIAGTGGGHTPPGVADTLATLVAAGTPVVLASRCPAGPLLQDTYGEKGGEGHLKSVGVIPVGHLPALKARLRLQIALALGHTPRKAFPVAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0R1</accession>
    <name>A0A0F7N0R1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl-CoA hydratase 2</fullName>
            <ecNumber evidence="1">4.2.1.119</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Enoyl-CoA hydratase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_04545</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3R)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:26526"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57319"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="EC" id="4.2.1.119"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="4.2.1.119" evidence="1"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014936.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_04545"/>
    <dbReference type="EnsemblBacteria" id="AKH81581">
        <property type="protein sequence ID" value="AKH81581"/>
        <property type="gene ID" value="AA958_04545"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_04545"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.958"/>
    <dbReference type="OrthoDB" id="1380653at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03450">
        <property type="entry name" value="NodN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039375">
        <property type="entry name" value="NodN-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MaoC-like" evidence="5">
        <location>
            <begin position="16"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH81581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="153" mass="16534" checksum="95EC6221E7483ED3" modified="2015-07-22" version="1">MAEPRTFTSVDELKGAVGEELGYTDWVEIDQRRVDLFAEATGDHQWIHVDPERAAAGPFGGTIAHGYLTLSLLPLFGPQLIDVTGVRMGVNYGTNKVRFPAPVPVGSRLRASATITDVAEVTDGVQLAVRYTVEREGGGKPVCVAESVVRYSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0T8</accession>
    <name>A0A0F7N0T8_9ACTN</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_04710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81611.1"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_04710"/>
    <dbReference type="EnsemblBacteria" id="AKH81611">
        <property type="protein sequence ID" value="AKH81611"/>
        <property type="gene ID" value="AA958_04710"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_04710"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.993"/>
    <dbReference type="OrthoDB" id="1271038at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="337" mass="34381" checksum="354517326FB003F1" modified="2015-07-22" version="1">MNTAARAGLFAGALAVAFAGAYGVGSAVGPVTDEDTAPAHGGHAADTGAGAREEAGKDAGEKGDGHGGGHGEDAGPAAGGLQLSESGYTLDLDTRRIDARSPAELRFAVRGADGEPVTSYEREHGKELHLIVASRDLGTYRHLHPVRDAAGTWSTPVELPKAGDYRVFADFVPTGGPENGLTLGGDLAVAGDYRPAALAEPERTATVDGYEVTLDGALTPGSAREVEFSVEKDGKPVTDLQPYLGAYGHLVALRAGDLAYLHVHPNGEPGDGSTEPGPEVAFSATAPSTGSYRLFLDFKHDGEVRTAAFTVTAGGSADGEQDAESGQDEADGGGHSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N141</accession>
    <name>A0A0F7N141_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptide ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_01845</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81118.1"/>
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    </dbReference>
    <dbReference type="RefSeq" id="WP_047014482.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_01845"/>
    <dbReference type="EnsemblBacteria" id="AKH81118">
        <property type="protein sequence ID" value="AKH81118"/>
        <property type="gene ID" value="AA958_01845"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_01845"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.401"/>
    <dbReference type="OrthoDB" id="1181903at2"/>
    <dbReference type="Proteomes" id="UP000034283">
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    </dbReference>
    <dbReference type="GO" id="GO:0005524">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
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    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="15"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="51"/>
            <end position="58"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH81118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="270" mass="28468" checksum="B7972D6241D084F9" modified="2015-07-22" version="1">MSSATTAPVRAGAAARVVDAVKVYGSGDTEVRALDGVGVAFPAGRFTAIMGPSGSGKSTLMHCAAGLDTLTAGAAFIGDTELGALDDKRLTMLRRDRIGFVFQAFNLLPTLTVAENITLPMDLAGRRGEPAWIDSLVDVVGLRDRLHHRPAELSGGQQQRVAVARAFAGRPDVVFADEPTGNLDSRSGAEVLGLLAGTVRELGRTVVMVTHDPVAAAYADEVVFLADGRLVDRMAAPTADRVLDRMQRFVGESPRTARSLDTTAERKSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N1G3</accession>
    <name>A0A0F7N1G3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ArsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_02795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014641.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_02795"/>
    <dbReference type="EnsemblBacteria" id="AKH81278">
        <property type="protein sequence ID" value="AKH81278"/>
        <property type="gene ID" value="AA958_02795"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_02795"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.598"/>
    <dbReference type="OrthoDB" id="1617768at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
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    </dbReference>
    <dbReference type="Pfam" id="PF01022">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="247"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="323" mass="35105" checksum="C282B2452E67C64A" modified="2015-07-22" version="1">MGWWQVDADTLAGSRFVVSPLAETLACLKTLARGTPSHPGERAWLDAHLPAYRARQAADPVADELVRAGLLRPWNADFLTPTPTGAAGASFEEELAAVRATPPDAARADVAVSLDGRLPERLRRDDLPRRAAEIMEWVWRETVLPDWPRRRRIIEADIVARTAQVGHGGWAAALDALRPGTRWLGASRLQINVRDYPPRDVSGAQLLFVPVVPRTGWVCWEAPHRYALVYPCAGALADTGTAAPAESLGRLLGPGRATVLALLDTPKSTTQLVALTGQGLGSVGRHLRVLRDARLVGRRRAGRSVLYYRTAVGEVLVAAERDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N1G9</accession>
    <name>A0A0F7N1G9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_09445</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_026276023.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_09445"/>
    <dbReference type="EnsemblBacteria" id="AKH82415">
        <property type="protein sequence ID" value="AKH82415"/>
        <property type="gene ID" value="AA958_09445"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_09445"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1993"/>
    <dbReference type="OrthoDB" id="1805193at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH82415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="77" mass="8945" checksum="814C781546F908F1" modified="2015-07-22" version="1">MGAHSRKCDWCGNGTPIVRDMEPLNPDYQYWCEECARALIIKGDPIETYRELEGEPIYGRLLDEHCTLKRFYSFATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2I7</accession>
    <name>A0A0F7N2I7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">D-alanyl-D-alanine dipeptidase</fullName>
            <shortName evidence="3 4">D-Ala-D-Ala dipeptidase</shortName>
            <ecNumber evidence="3 4">3.4.13.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_01615</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3 4">
            <text>D-alanyl-D-alanine + H2O = 2 D-alanine</text>
            <dbReference type="Rhea" id="RHEA:20661"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57416"/>
            <dbReference type="ChEBI" id="CHEBI:57822"/>
            <dbReference type="EC" id="3.4.13.22"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the peptidase M15D family.</text>
    </comment>
    <dbReference type="EC" id="3.4.13.22" evidence="3 4"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014441.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_01615"/>
    <dbReference type="EnsemblBacteria" id="AKH81077">
        <property type="protein sequence ID" value="AKH81077"/>
        <property type="gene ID" value="AA958_01615"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_01615"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.355"/>
    <dbReference type="OrthoDB" id="880710at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016805">
        <property type="term" value="F:dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01924">
        <property type="entry name" value="A_A_dipeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000755">
        <property type="entry name" value="A_A_dipeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009045">
        <property type="entry name" value="Hedgehog_sig/DD-Pept_Zn-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01427">
        <property type="entry name" value="Peptidase_M15"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026671">
        <property type="entry name" value="AA_dipeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55166">
        <property type="entry name" value="SSF55166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3 4" id="KW-0224">Dipeptidase</keyword>
    <keyword evidence="3 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 4" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3 4" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002518989" description="D-alanyl-D-alanine dipeptidase" evidence="5">
        <location>
            <begin position="36"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="245"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="3">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR026671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH81077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="275" mass="30794" checksum="E0643C8401FD0C8A" modified="2015-07-22" version="1">MSMNAALARPLSRFAVLAAAAALAVTATAAPPATAKPEPKAPKEFVALSDVDPTILHDIRYVTPHNFTGERIDGYRKPMCILTEDAARALRKAQRAFLRDGYTLKVYDCYRPQRAVDQFVTWAEDLGDQRMKDEFYPRVDKSRLFEDGYIAARSGHSRGSVVDLTLVKLPAGNTRPYVPGEPLVDCAAPQEERFPDNSLDMGTGYDCFDTLSHTLDERVQGEQRANRLRLKDGLEAAGFVNYAYEWWHFALAGEPFPDTYFDFPVHRRSLSGNGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2M7</accession>
    <name>A0A0F7N2M7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_12050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016180.1">
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    <dbReference type="STRING" id="444103.AA958_12050"/>
    <dbReference type="EnsemblBacteria" id="AKH82845">
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        <property type="gene ID" value="AA958_12050"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_12050"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2535"/>
    <dbReference type="OrthoDB" id="1744037at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR023187">
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    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01117">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="23"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="164" mass="18703" checksum="24E43F9603371755" modified="2015-07-22" version="1">MRDEVDRLVAAWRRERPDLDVEPLEVLSRVSRLARHLDRARRLAFAEHGLEGWEFDVLTALRRAGEPYQLSPGQLLTQTLVTSGTMTNRIDRLAKKDLVERLPDPSDRRGVLVRLTAEGRERADAALAALLKQERAILAELAPERRRELADLLRQLTAPFDNVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2W5</accession>
    <name>A0A0F7N2W5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_12810</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016294.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH82960">
        <property type="protein sequence ID" value="AKH82960"/>
        <property type="gene ID" value="AA958_12810"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_12810"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2691"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519113" evidence="2">
        <location>
            <begin position="33"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH82960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="134" mass="13210" checksum="C0F75A7F1711FF33" modified="2015-07-22" version="1">MSVRPRRLFSLVVPVLSAAALCVLFLPSVASAQSSGGAGSASGAAGRYIDPGMNAGASMGATTTASGGFPASTGTATGFTTTSGSTGTTTGDGDVGWRPVLLVLGGVFLVYFLAGRALRLIGAAAGTVRRRRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N374</accession>
    <name>A0A0F7N374_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Periplasmic immunogenic protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_06025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015187.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_06025"/>
    <dbReference type="EnsemblBacteria" id="AKH81834">
        <property type="protein sequence ID" value="AKH81834"/>
        <property type="gene ID" value="AA958_06025"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_06025"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1259"/>
    <dbReference type="OrthoDB" id="1821429at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007497">
        <property type="entry name" value="DUF541"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04402">
        <property type="entry name" value="SIMPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="235" mass="25641" checksum="2AE1192741CD6AB8" modified="2015-07-22" version="1">MTNPPPASAPAPHGTPDQPRLAVRGEARLEVDPEIARIAVTVAVRGTDRRTALEDLTRRNAEARDLIRSYGDAVEKLETGALLVTPELGRHGRGERVRRYHGRVRLAATFSDFTALGELSTRAADLELTSVEGPWWALRPDSPVHREARQQAVREAVTRAREYAEAVGAELTAVLEIADEGAERQEAWLATEATRGYGGPAVPGGEAAPALDLEPQRQTVYARVNARFTMSRPQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3A8</accession>
    <name>A0A0F7N3A8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_10040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015853.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_10040"/>
    <dbReference type="EnsemblBacteria" id="AKH82511">
        <property type="protein sequence ID" value="AKH82511"/>
        <property type="gene ID" value="AA958_10040"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_10040"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2114"/>
    <dbReference type="OrthoDB" id="1239213at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038732">
        <property type="entry name" value="HpyO_NAD-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13454">
        <property type="entry name" value="NAD_binding_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_binding_9" evidence="1">
        <location>
            <begin position="10"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="651" mass="70717" checksum="50AE2099B360E7B0" modified="2015-07-22" version="1">MSNGQLNVCVVGAGPRGLSVLERICANERKSPSHGELRVHVVDPHPPGAGRVWRTDQPDLLLMNTVASQVTVYTDDSVEMEGPIEAGPSLYEWARSVVRGDGGGPELPGGALAEARQLGPDDYPTRAFYGHYLGDTFHRVVAGAPEHVTVLVHRSTAIALDEEEDGAGQCLALADGTRLHHLDAVVLAQGHLPARATEREKELAREAAVCGLVLVTPVNPADADLSGIKPGQNVVLRGLGLNFFDHLALLTTGRGGRFERSGDRLVYRPSGREPRLFAGSRRGVPYHARGHNEKGAHGRYEPRLLTPEVIARLRERGAAGRRVYFAVDLWPLIAKEVASVYYGALLAARGRGEEREAFVARYLAAPTAEVEAALLDEHRIPAADRWDWDRIDRPYATREFASRDEFRDWLLGHLAEDVREAREGNVSGPLKAALDVLRDLRNEIRLVVDHGGLEGISYRDDLQNWYTPLNAYLSIGPPASRIEETIALAHAGILEFMGPELRVRIDRTGAEPAFVAESSRVKGPPVRAEALIEARLPEPDIRRTADPLLTHLLATGQCRPYRISSDSGADVVTGGLAVGERPYRLLDAAGVLHPRRFAYGVPTEAVHWVTAAGIRPGVNSVTLGDSDAIARAVLALTPADGPRPHATEELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3L8</accession>
    <name>A0A0F7N3L8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">4-hydroxyphenylpyruvate dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_10820</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="5">Binds 1 Fe cation per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the 4HPPD family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015976.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_10820"/>
    <dbReference type="EnsemblBacteria" id="AKH82636">
        <property type="protein sequence ID" value="AKH82636"/>
        <property type="gene ID" value="AA958_10820"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_10820"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2276"/>
    <dbReference type="OrthoDB" id="402639at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003868">
        <property type="term" value="F:4-hydroxyphenylpyruvate dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009072">
        <property type="term" value="P:aromatic amino acid family metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07250">
        <property type="entry name" value="HPPD_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08342">
        <property type="entry name" value="HPPD_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005956">
        <property type="entry name" value="4OHPhenylPyrv_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041735">
        <property type="entry name" value="4OHPhenylPyrv_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041736">
        <property type="entry name" value="4OHPhenylPyrv_dOase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11959">
        <property type="entry name" value="PTHR11959"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009283">
        <property type="entry name" value="HPP_dOase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01263">
        <property type="entry name" value="4HPPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="VOC" evidence="6">
        <location>
            <begin position="22"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="6">
        <location>
            <begin position="184"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="349"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR009283-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH82636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="381" mass="41807" checksum="71808023CD4FA73F" modified="2015-07-22" version="1">MTETIDQPAPQIRQDDPFPVKGMDAVVFAVGNAKQAAHYYSTAFGMKLVAYSGPENGSRETASYVLENGSARFVLTSVIKAATDHGRFLDAHVTEHGDGVIDLALEVPDARAAYAHAVAQGATGLQEPYELKDEHGTVVLAAIATYGQTRHTLVERTGYDGPYLPGYTAAEPLVAPPARRTFQAVDHCVGNVELGKMDEWVAFYNKVMGFTNMKEFVGDDIATEYSALMSKVVADGTLKVKFPINEPAPGKKKSQIDEYLEFYNSPGVQHIALATNDIVGTVRTMRAAGVAFLSVPDAYYDTLGEWVGDTRVPIDELRELKILADRDEDGYLLQIFTKPVQDRPTVFFEIIERHGSMGFGKGNFKALFEAIEREQDKRGNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N423</accession>
    <name>A0A0F7N423_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2-dehydro-3-deoxy-phosphogluconate aldolase</fullName>
            <ecNumber evidence="3">4.1.2.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_07690</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-dehydro-3-deoxy-6-phospho-D-gluconate = D-glyceraldehyde 3-phosphate + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:17089"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:57569"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.1.2.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the KHG/KDPG aldolase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.14" evidence="3"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015483.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_07690"/>
    <dbReference type="EnsemblBacteria" id="AKH82133">
        <property type="protein sequence ID" value="AKH82133"/>
        <property type="gene ID" value="AA958_07690"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_07690"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1616"/>
    <dbReference type="OrthoDB" id="1497385at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008675">
        <property type="term" value="F:2-dehydro-3-deoxy-phosphogluconate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00452">
        <property type="entry name" value="KDPG_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000887">
        <property type="entry name" value="Aldlse_KDPG_KHG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031337">
        <property type="entry name" value="KDPG/KHG_AS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031338">
        <property type="entry name" value="KDPG/KHG_AS_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30246">
        <property type="entry name" value="PTHR30246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01081">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01182">
        <property type="entry name" value="eda"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00159">
        <property type="entry name" value="ALDOLASE_KDPG_KHG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00160">
        <property type="entry name" value="ALDOLASE_KDPG_KHG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH82133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="218" mass="21408" checksum="D54DF79A3381CCC3" modified="2015-07-22" version="1">MTTDSASTSASVPSSVLGLAPVIPVVVLDDAADAVPLARALVAGGLPAVEVTLRTPAALDAIRAIAAEVPDAVVGAGTVLDAAAVDASAAAGARFLVSPGSTDGLLAAMAASGLAYLPGVSTVSEAMGLLERGLTEMKFFPAEASGGIAYLKSLGSPLPRARFCPTGGVTAESAPRYLALPNVGCVGGTWMLPRAALAAKDWATVEKLAAEAAALGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N467</accession>
    <name>A0A0F7N467_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_07865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015514.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_07865"/>
    <dbReference type="EnsemblBacteria" id="AKH82164">
        <property type="protein sequence ID" value="AKH82164"/>
        <property type="gene ID" value="AA958_07865"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_07865"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1656"/>
    <dbReference type="OrthoDB" id="1966197at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022062">
        <property type="entry name" value="DUF3618"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12277">
        <property type="entry name" value="DUF3618"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="173" mass="18530" checksum="087BD7DCB398EB90" modified="2015-07-22" version="1">MGTASPEKLRAEIEDTRSRLTADLDRLAERVSPRAAAGRQGERVRGAATGLRERVMGSATESTEQARERTRQATEAAGEAARQAPERLARQTQGNPLAAGLVAFGAGMLAASMIPESPAEERAAAQMADRAGEFAGPVKDVARESAQRMKEDATQTAKEAAREVKERTGEERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4G0</accession>
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        <name type="scientific">Streptomyces sp. CNQ-509</name>
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        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
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            <end position="70"/>
        </location>
    </feature>
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        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AKH82259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="186" mass="19825" checksum="2D2E1AA2D822A24D" modified="2015-07-22" version="1">MVPSDGAPLDAIAASLQRERRRTGLTLTELARRAGIAKSTLSQLESGTGNPSVETLWALSVALDVPFSRLVEPPRPRVQVIRRGEGPSVPSEHADYAATLLASSPAHARRDIYLVTVQPGVPRRSDPHSPGVVEHVILSSGHARVGVAEEPVDLEPGDYTSYPADVPHVFEALAPDTVAVLVSEHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4R7</accession>
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        <lineage>
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    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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            <end position="50"/>
        </location>
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        <location>
            <begin position="70"/>
            <end position="94"/>
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            <end position="1000"/>
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            <begin position="272"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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            <dbReference type="Proteomes" id="UP000034283"/>
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    </evidence>
    <sequence length="1014" mass="107423" checksum="9B8F84050CE7165D" modified="2015-07-22" version="1">MARSSANRTPVPVRIRRRTFGDVVRAFFAFLALVVLVVGVPGALAYFIGWPLPDSAPSLSMLNEDITADVFLKVFAVVVWLAWAQFAACVLVEAKAAVSGMGMPGRVPGSGASQALARQLVAAVLLLTAGAASFAPGLSQLGQELDQHKPPPVAAAQQTPGQQVDTARPAVDVETPRGQGTGGEVQKDTREQAERDTKFYRIQPPEGRHHDSLWEIAERHLGDGRRYGEIYQLNKDRIQPDGSKLSQASLIRPGWIMEMPADAHGGDLVEMSDERNEVSKSEAEQISEYDKSSPTLDERGPGGDDRQATSGRGERLVPDTPAVDRDSGDRGGEQSVQQIPTRESDGGDAGSDRGDQAVPEVQSDGGGIGLPEVLIAAPLLAAGVLGALSRRRRQALWQAAFQSGGAGRTGAEPTGRAALARDALLVGADPGGVRFLDRALRGLSASLTEAARPLPTIYAAWLTDADLYLQLAGVAGEPPAPWRTGQDQTFWRIDRADIESYPQPDEADDAAAPYPGLASLGTREEARLLLNLEAVPGIAAVKGAPADRLAVLSSIAAELATNGWSDRMSVTVVGFGERLTELAPTRVRYLEDVPALIEVMEAESAQRANALGNAGHDSVLTGRAGQAGRTQWAPHLVIVATEPTAAEADRLAHLAGGSSRLGIGYLVGTGQEELAGASWEFEITRDGRLRAPLLGLELAAQRLPQEQHEALVELFSQVEVEGAATSGTEGRGISVTRAAGEVGFTVDLSEQGRPAVYARLLGSYEIMGLAEPDGERSPLLREALALLLFHREGVHPQVLAAALWPRGVTDDVRDAFVERLVTWLGRDPSGAARLAPDADGRLALSTSVVSDWDVLRTLHLEATDPTRQSSPQTRERLLNDALALAAGPLLADRPQGRYGWLANEIVEAQLPLLVADAGLALSALRRESGQADGAVAAVQAALVVAPADERLWNELLRAVHATGETHRLEATASDLLDRSAALHGARGLPPRTEALLDELLPGWRTQAGSAGAAS</sequence>
</entry>
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    <accession>A0A0F7N4V2</accession>
    <name>A0A0F7N4V2_9ACTN</name>
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    </gene>
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        </lineage>
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            <authorList>
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_09565"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2016"/>
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        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
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        <location>
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            <end position="131"/>
        </location>
    </feature>
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        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="131"/>
        </location>
    </feature>
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        <location>
            <begin position="36"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH82433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="131" mass="13203" checksum="5DA4FCB89AA2FCEB" modified="2015-07-22" version="1">MKKYLKTAAVAVTMLGASAMAAPQALAADDTGDGPYANGNGSTQAYGNTKTGGYMSPNMSLINGSFNEPCIALPQVAKNFAGTTAVSEILSQNQNQTCAKNSSADQGDAPLSHLLDDFPILSGNGAGNDAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N551</accession>
    <name>A0A0F7N551_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_10175</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
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            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the DedA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015875.1">
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_10175"/>
    <dbReference type="EnsemblBacteria" id="AKH82533">
        <property type="protein sequence ID" value="AKH82533"/>
        <property type="gene ID" value="AA958_10175"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_10175"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2142"/>
    <dbReference type="OrthoDB" id="1928533at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032818">
        <property type="entry name" value="DedA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="SNARE_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30353">
        <property type="entry name" value="PTHR30353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="SNARE_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="61"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="205"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH82533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="243" mass="26189" checksum="FEAC06DAEE4BA1D1" modified="2015-07-22" version="1">MNTLALGPGWLDPDFLIDKFGVLGVLVIVFAESGLLIGFFLPGDSLLFTTGLLITSDVLDFPLWLMCVLIAVAAIAGDQVGYLFGRKVGPALFNRPDSKLFKQENVQKAHEFFEKHGPKSLVLARFVPIVRTFTPIIAGVSRMNYRQFVVFNVIGGILWGVGVTLLGAALGRIDFVHENIEAILIGIVLLSVLPIVVEYLRARSRAKKAPPAAPSADEPEGHPATPAADGGDGGPQRGRHARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N554</accession>
    <name>A0A0F7N554_9ACTN</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_06645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_06645"/>
    <dbReference type="EnsemblBacteria" id="AKH81942">
        <property type="protein sequence ID" value="AKH81942"/>
        <property type="gene ID" value="AA958_06645"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_06645"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1386"/>
    <dbReference type="OrthoDB" id="2084255at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010035">
        <property type="entry name" value="Thi_S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003749">
        <property type="entry name" value="ThiS/MoaD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34472">
        <property type="entry name" value="PTHR34472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02597">
        <property type="entry name" value="ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="SSF54285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01683">
        <property type="entry name" value="thiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="86" mass="8804" checksum="18E73E8667FD7D85" modified="2015-07-22" version="1">MTQDATQTRTDTRTDSPAHAPTITVNGAPRTIAAGLTLDALVATLTAAHRGVAAAVNEDVVPRGDWPTTILGDGDRVEILTAVQGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5A3</accession>
    <name>A0A0F7N5A3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ArsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_18205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_18205"/>
    <dbReference type="EnsemblBacteria" id="AKH83820">
        <property type="protein sequence ID" value="AKH83820"/>
        <property type="gene ID" value="AA958_18205"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_18205"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3827"/>
    <dbReference type="OrthoDB" id="1617768at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR045981">
        <property type="entry name" value="DUF5937"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19361">
        <property type="entry name" value="DUF5937"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="270"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="362" mass="39142" checksum="02613F832CC778F4" modified="2015-07-22" version="1">MSVTLDITGLAVERIGFTPSPLAELGAALHALAAPGHHPGAAEWTTATAAALDPGLADRLSEGEFLWSAGRADILLPAAPEATLAEELDALDRIPDDMFVTAAFEIVCNPAYQYGSPSPHTDPVVRRIAIERAAARGPRQAAFVERMLADPDGLRVWLRRLFEDCAEAFFDETWEQVRHSLAADARHKTDLLRRKGLAATLADVSSALRLDEGEDGSVRIVADKLSNGGAVASESVTFLPTAFGWPHVLVVYAPGWQPVIQYPIPSPDLPRAPTLETLQLRLEALAHPVRLRLCRTISRTPTTTGELAAVHQLTAPEVSRHLAVLKRAGLVVTRRRGRYVQYELSLPAVARLGGSLLEGLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5C8</accession>
    <name>A0A0F7N5C8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_07005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015358.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH82007">
        <property type="protein sequence ID" value="AKH82007"/>
        <property type="gene ID" value="AA958_07005"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_07005"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1465"/>
    <dbReference type="OrthoDB" id="1809950at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="15"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="180" mass="18978" checksum="1648FAE97A7D2ED0" modified="2015-07-22" version="1">MTDAQDGGAVGGGELRIRPARAADGGLLRELDAATWSHLHAVTAPPDTDAPFFDERHHPDDYLVAELPGAAPTAPARVVGYICVVPPTSLTVNGHVRQIQGLVVAPEARGAGVARALLRAGAEHARAAGARRLTLRVLGHNAPARRLYESEGFAVEGVLPEEFLLDGTYVDDVLMGRTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5D8</accession>
    <name>A0A0F7N5D8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_10725</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015960.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_10725"/>
    <dbReference type="EnsemblBacteria" id="AKH82619">
        <property type="protein sequence ID" value="AKH82619"/>
        <property type="gene ID" value="AA958_10725"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_10725"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2256"/>
    <dbReference type="OrthoDB" id="1811367at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070122">
        <property type="term" value="F:isopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140492">
        <property type="term" value="F:metal-dependent deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028090">
        <property type="entry name" value="JAB_dom_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14464">
        <property type="entry name" value="Prok-JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="6">
        <location>
            <begin position="2"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH82619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="150" mass="16504" checksum="2DA6E80CF8050C5E" modified="2015-07-22" version="1">MLTITEELYEQIVAHARKDHPDEACGVVAGPAPAPADGRPQRFIPMLNAARSPTFYEFDSQDLLRLYREMDDRDEEPVVIYHSHTATEAYPSRTDVSYANEPGAHYVLVSTAESGDGEGPVSFRSFRIVDGVITEEDVTVIASYDDAPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5P2</accession>
    <name>A0A0F7N5P2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycosyl transferase family 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_07760</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015497.1">
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_07760"/>
    <dbReference type="EnsemblBacteria" id="AKH82147">
        <property type="protein sequence ID" value="AKH82147"/>
        <property type="gene ID" value="AA958_07760"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_07760"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1632"/>
    <dbReference type="OrthoDB" id="694191at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="5">
        <location>
            <begin position="21"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="4">
        <location>
            <begin position="237"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="418"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH82147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="443" mass="47498" checksum="468918DA243DD8DB" modified="2015-07-22" version="1">MTAEVPLRIALLSYKGNPFCGGQGVYVRHLSRELARLGHRVEVIGAQPYPVLDPGVTLTELPSLDLYRQPDPFRTPARGEYRDWIDLLEVGTMWTGGFPEPLTFSLRARRHLAARRGEFDVVHDNQTLGYGLLGGARALGAPLVTTVHHPITVDRDLELAAAPDWRRRYSVRRWYGFTRMQRRVARRLPAVLTVSGSSRTQITAQLGARPERVHVVPIGADTELFTPDPSVPRVPGRIVTTASADVPLKGLVHLVEALAKIRTEQPDAHVVVVGKRAEDGPVAQAVERFGLGGAIRFVTGISDEELVGLLRSAQVACVPSLYEGFSLPAAEAMATGTPLVATTGGAIPEVAGPDNETSLAVPPGDAGALAGALTRLLADAPLRARLGAAGRERVLARFTWAQAAKQTAERYREAIAADAATAARPRPRGGPATARMRAAGGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5X7</accession>
    <name>A0A0F7N5X7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HATPase_c domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_19330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017275.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_19330"/>
    <dbReference type="EnsemblBacteria" id="AKH83980">
        <property type="protein sequence ID" value="AKH83980"/>
        <property type="gene ID" value="AA958_19330"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_19330"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4064"/>
    <dbReference type="OrthoDB" id="1832160at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HATPase_c" evidence="1">
        <location>
            <begin position="27"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="142" mass="14889" checksum="8F184AD07EDCA161" modified="2015-07-22" version="1">MTPAAAAAPVTADAPCPYAFEVGCAPDRSRVRCLRQITAGYLALWDLTGALADDIVIVVSELVSNAVLHGKGDVFLHVQYAAGELQIEVSDANPAPAKLRHAGDDEDSGRGLLLVADLAHGWGVTNGGRTTWCRFLVPAGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N694</accession>
    <name>A0A0F7N694_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MOSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_12150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016199.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_12150"/>
    <dbReference type="EnsemblBacteria" id="AKH82864">
        <property type="protein sequence ID" value="AKH82864"/>
        <property type="gene ID" value="AA958_12150"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_12150"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2556"/>
    <dbReference type="OrthoDB" id="1885467at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005302">
        <property type="entry name" value="MoCF_Sase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005303">
        <property type="entry name" value="MOSC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03473">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03476">
        <property type="entry name" value="MOSC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="SSF50800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51340">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MOSC" evidence="2">
        <location>
            <begin position="104"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH82864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="250" mass="27294" checksum="C6C2CD8FE4D33CD0" modified="2015-07-22" version="1">MPELPPAIPAPPPSPGPSDPTVAMLRRFPVKSMLGERLPELVIDERGTIGDRLWAVTYGDGKLGSGKNSRRFRRTEGLLHFSASYAAAHDAATARPHVVTPEGSVLRDDAHLAELLGADVRLAREDAVSHYDDCGVTLIGTASLHALGRILGDTEPADARRFRKNILLDTGEPWIEEDWVGREIAVGDEVRLRVVKRMKRCVMTTMAQRDLPEDRRVLKTLTADRGMCIGIGADVLTPGTVRLGDTVRPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6F1</accession>
    <name>A0A0F7N6F1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-oxoacid:ferredoxin oxidoreductase subunit beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_20705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017496.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_20705"/>
    <dbReference type="EnsemblBacteria" id="AKH84210">
        <property type="protein sequence ID" value="AKH84210"/>
        <property type="gene ID" value="AA958_20705"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_20705"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4367"/>
    <dbReference type="OrthoDB" id="981516at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TPP_enzyme_C" evidence="1">
        <location>
            <begin position="70"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="358" mass="38511" checksum="BBE641B29AA1AD76" modified="2015-07-22" version="1">MAETTAGGPAIDALSLIPKAEAKQSMKDFKTDQEVRWCPGCGDYAVLAAVQGFMPELGLAKENIVFVSGIGCSSRFPYYMNTYGMHSIHGRAPAIATGLASTRRDLSVWVVTGDGDALSIGGNHLIHALRRNVNLKILLFNNRIYGLTKGQYSPTSEVGKVTKSTPMGSLDAPFNPVSLALGAEASFVARTVDSDRKHLTETLRAAAAHPGTALIEIYQNCNIFNDNAFEVLKDRQQAQEAVIRLEHGRPIRFGTDDHKGVVRNPATGDLEIVEVTPSIESDVLVHDAHAATPTTAFALSRLADPNTLHHTPIGILRDVNRQVYDTEMAEQLDDAVQQKGKGDLAGLLAGGDTWTVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6K0</accession>
    <name>A0A0F7N6K0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_09500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_09500"/>
    <dbReference type="EnsemblBacteria" id="AKH82422">
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        <property type="gene ID" value="AA958_09500"/>
    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH82422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="160" mass="16794" checksum="3CFD22F60B2B9E9B" modified="2015-07-22" version="1">MGGRPPYADGDEPDSHHHGGADEEFAAVVLDEDFVRSAHFHEPSAVERMVGAAEARAQAEAVLDDVANDDRIYDGWDDPDAPDPYGPYGGALRPYRGHGHWQRPVALLLALLLGVGIVALSFAAVYRSGADGRDDAPPPGGSSPSATTGADALEPSLTPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N755</accession>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">AA958_21990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_21990"/>
    <dbReference type="EnsemblBacteria" id="AKH84420">
        <property type="protein sequence ID" value="AKH84420"/>
        <property type="gene ID" value="AA958_21990"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_21990"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4631"/>
    <dbReference type="OrthoDB" id="2024943at2"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="77"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="387" mass="38353" checksum="463F68A6694FD126" modified="2015-07-22" version="1">MVDDRYGWLDEDVAERLLRGEPLDFADGNGRRGRKHWSPEDRAAAERLAAVLARVAESGRPDANGRMPGEQAALAAFRAAQESPSPASAAEFAAESPFDGRRGRHRSGVVARLRSLRLSVVGAVAACALGGVAVASSAGVLPSPSFIQDTGGNRSPSVGATSSAEPPGGEKENGSAPEDGKGSDKDGKDKDSGKDGKDSQDHSRGTDTDLPGRGVIGDVRGNEPPNMADADAVLDQLCRDYLAAQAGTGPMPGQQRLRVLEQAAGSPAAMASYCSNRLGTSVGTPGGATGGTGGSSGGSTGGASEEPTSPSPSPTDPGTDPGGSTGGSSGSGGETGGGDPDGGSENGGSEGPPQEGPSSNPSANISESPAPEPSATATVAEPEETVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7A7</accession>
    <name>A0A0F7N7A7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">Protein translocase subunit SecA</fullName>
            <ecNumber evidence="11">7.4.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">secA</name>
        <name evidence="17" type="ORF">AA958_11260</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell membrane</location>
            <topology evidence="11">Peripheral membrane protein</topology>
            <orientation evidence="11">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="11">Distribution is 50-50.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11 12">Belongs to the SecA family.</text>
    </comment>
    <dbReference type="EC" id="7.4.2.8" evidence="11"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016050.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_11260"/>
    <dbReference type="EnsemblBacteria" id="AKH82712">
        <property type="protein sequence ID" value="AKH82712"/>
        <property type="gene ID" value="AA958_11260"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_11260"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2373"/>
    <dbReference type="OrthoDB" id="212453at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017038">
        <property type="term" value="P:protein import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd18803">
        <property type="entry name" value="SF2_C_secA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01382">
        <property type="entry name" value="SecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000185">
        <property type="entry name" value="SecA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020937">
        <property type="entry name" value="SecA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011115">
        <property type="entry name" value="SecA_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014018">
        <property type="entry name" value="SecA_motor_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011130">
        <property type="entry name" value="SecA_preprotein_X-link_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044722">
        <property type="entry name" value="SecA_SF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011116">
        <property type="entry name" value="SecA_Wing/Scaffold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036266">
        <property type="entry name" value="SecA_Wing/Scaffold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036670">
        <property type="entry name" value="SecA_X-link_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30612">
        <property type="entry name" value="PTHR30612"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07517">
        <property type="entry name" value="SecA_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01043">
        <property type="entry name" value="SecA_PP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07516">
        <property type="entry name" value="SecA_SW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00906">
        <property type="entry name" value="SECA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00957">
        <property type="entry name" value="SecA_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00958">
        <property type="entry name" value="SecA_PP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81767">
        <property type="entry name" value="SSF81767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81886">
        <property type="entry name" value="SSF81886"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00963">
        <property type="entry name" value="secA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01312">
        <property type="entry name" value="SECA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51196">
        <property type="entry name" value="SECA_MOTOR_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 11 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-1278">Translocase</keyword>
    <keyword evidence="9 11 12" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 11 12" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SECA_MOTOR_DEAD" evidence="16">
        <location>
            <begin position="1"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="87"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="436"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="885"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="103"/>
            <end position="107"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="514"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AKH82712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="947" mass="106425" checksum="36D12A476B942CF9" modified="2015-07-22" version="1">MSVFGKIMRAGEGKILRKLNRIADQVNSIEEDFTNLSDAELRALTEEYKQRYEDGESLDDLLPEAFATVREAAHRILGERHYDVQIMGGAALHEGYVAEMKTGEGKTLVGTLPAYLNAISGKGVHIVTVNDYLAQRDSEWMGRVHRFLGLSVGCILANMPPAQRREQYKCDITYGTNNEFGFDYLRDNMAWSKDELVQRGHNFAIVDEVDSILIDEARTPLIISGPADQATKWYADFAKLVTRLSKGEPGDPRLGKQETGDYDVDEKKRTVAIHEAGVAKVENYLGIDNLYESVNTPLVGYLNNAIKAKELFKKDKDYVVMNGEVMIVDEHTGRILAGRRYNEGMHQAIEAKEGVDIKDENQTLATITLQNFFRLYKRHDRDGKELPGLAGMTGTAMTEAAEFQQIYKLGVVPIPTNRPLARMDQSDLIYRTEEAKFNAVVDDIEEKYKKGQPVLVGTTSVEKSEYLSQQLSKRGVQHEVLNAKQHDREAIIVAQAGRRGAITVATNMAGRGTDIKLGGNPDDLAEADLRQQGLDPVEHAEQWAAALPAALEKAEAAVKAEYEEVKDLGGLYVLGTERHESRRIDNQLRGRSGRQGDPGESRFYLSLGDDLMRLFKAQLVERVMSMANVPDDVPIENKMVTRAIASAQSQVEQQNFETRKNVLKYDEVMNRQREVIYGERKRVLEGEDLHEQVRHFMDDTIDAYIQAETVEGFAEEWDLDRLWRAFKQLYPVSVTVEELEEAAGDRAGITPEFIEDMVKEDVRAQYEKREEQLGSEIMRELERRVVLSVLDRKWREHLYEMDYLQEGIQLRAMAQKDPLVEFQREGFDMFNAMMDGIKEESVGYLFNLEVQVEQQVEEVPVQDAAPADAAPQDAAPAPAILAKGLDQPQRPDRLHFSAPTAEGGVEEGELATDGAQSATSGGSGDGRTRAERRRAQKGGSKGKRRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7L3</accession>
    <name>A0A0F7N7L3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fructose-bisphosphate aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_19720</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2">Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017328.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_19720"/>
    <dbReference type="EnsemblBacteria" id="AKH84036">
        <property type="protein sequence ID" value="AKH84036"/>
        <property type="gene ID" value="AA958_19720"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_19720"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4156"/>
    <dbReference type="OrthoDB" id="827430at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00947">
        <property type="entry name" value="TBP_aldolase_IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000771">
        <property type="entry name" value="FBA_II"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01116">
        <property type="entry name" value="F_bP_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001359">
        <property type="entry name" value="F_bP_aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00167">
        <property type="entry name" value="cbbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00806">
        <property type="entry name" value="ALDOLASE_CLASS_II_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH84036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="291" mass="29856" checksum="F0F27D726FCE52B8" modified="2015-07-22" version="1">MPLTTTGELVAAARDAGHGVPAFNIITLEHAEAIAAGAEAAGAPAVLQISENAVRFHGGRLTPIAAATAAVARASSAPLSLHLDHVVSPELLRSAHGLGFSSVMFDASKMSYTDNVRATAEAVRWAHEHGIWIEAELGRVGGKEGEKVGGKEGEAPLDAHAPGVRTDPDEAVAYVTDTGVDALAVAVGSSHAMTERTAALDHGLIGRLRAAVAVPLVLHGSSGVPDEELRQAVASGMVKINVGTALNTAFTGAARAHLDAHPEVVDPRKYLAPGRDAMAATVRRFLEVVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7Q5</accession>
    <name>A0A0F7N7Q5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_15975</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016770.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH83458">
        <property type="protein sequence ID" value="AKH83458"/>
        <property type="gene ID" value="AA958_15975"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_15975"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3366"/>
    <dbReference type="OrthoDB" id="1439189at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="244"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH83458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="344" mass="35518" checksum="12FE03A33A77FBE1" modified="2015-07-22" version="1">MDLLRHLRYFRAVAEERHFGRAAERLRIAQPSLSQRIRRLERELGVRLFDRGSQGTALTPAGRLVLAEADQVLAAADRLAAAVARIGSGAAGTLRAAVPPHLGPAAVAALITGYRERSPGGELELRELTTTAQARELAAGTLDAGVVRHPCPAPGLAFGPVLHQPLGVLLAATDPLAAVERLTAADLSGRALVLTPRADDPALYDEVLTACARHGCTPAAVHEASGGDFTRALVLSTAPAAPAAPAHAEAPAAPGTQTAPEAPATPGGAVALLPRTTAGPGTVWRPLAGEPIGWRTSAAWPADGHNPAVARFAEAAHEAMRDHAGMRPARAAAVHPRPASEFPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7V5</accession>
    <name>A0A0F7N7V5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Penicillin-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_16345</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016823.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_16345"/>
    <dbReference type="EnsemblBacteria" id="AKH83518">
        <property type="protein sequence ID" value="AKH83518"/>
        <property type="gene ID" value="AA958_16345"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_16345"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3442"/>
    <dbReference type="OrthoDB" id="423699at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519290" evidence="1">
        <location>
            <begin position="32"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="2">
        <location>
            <begin position="156"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH83518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="484" mass="51989" checksum="4983F4A289A071B9" modified="2015-07-22" version="1">MNKPLRRVAVFCGLLVIALLVRVNWIQFVEADELRNHEDNRRVAIERYAHPRGNIIVGDKAITGSAETSGSDFRYKRTYKDGPLWAPVTGYASQAFGANQLEALNDGILTGNDDRLFFNRTIDMITGKDKKGGNVVTTLDANVQKAAFEGLGDRKGAVAAIDPETGAILGLASSPSYDPSSFAGNSDKDSENWVALNKDKDKPMLNRALRETYPPGSTFKVVTAAAALESGEYDMDEPTGAPETYKLPLSTNTLGNEVKNVCEDATLREALQWSCNSVYAMISDKVGNEGMIEMSEKFGFGNSELDTPVRAAESIYPEMDRPQNAMGGIGQASNRATPLQMAMVASAVANDGELMKPYMVEKLVAPNLNDIEVTQPQTLSEPLSGENAQKMQQMMETVVNEGTGSNARIDGATVGGKTGTAQHGIDNRDLPYAWFISYAKDPDSDKQIAVAVVVEDASANRDDISGGGVAAPIAKSVMEAGLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7W0</accession>
    <name>A0A0F7N7W0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">30S ribosomal protein S6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rpsF</name>
        <name evidence="9" type="ORF">AA958_16080</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Binds together with S18 to 16S ribosomal RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the bacterial ribosomal protein bS6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018838796.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_16080"/>
    <dbReference type="EnsemblBacteria" id="AKH83474">
        <property type="protein sequence ID" value="AKH83474"/>
        <property type="gene ID" value="AA958_16080"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_16080"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3388"/>
    <dbReference type="OrthoDB" id="1776954at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00473">
        <property type="entry name" value="bS6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00360">
        <property type="entry name" value="Ribosomal_S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000529">
        <property type="entry name" value="Ribosomal_S6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020815">
        <property type="entry name" value="Ribosomal_S6_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020814">
        <property type="entry name" value="Ribosomal_S6_plastid/chlpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035980">
        <property type="entry name" value="Ribosomal_S6_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014717">
        <property type="entry name" value="Transl_elong_EF1B/ribosomal_S6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21011">
        <property type="entry name" value="PTHR21011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01250">
        <property type="entry name" value="Ribosomal_S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54995">
        <property type="entry name" value="SSF54995"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00166">
        <property type="entry name" value="S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01048">
        <property type="entry name" value="RIBOSOMAL_S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6 8 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 8" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH83474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="96" mass="11173" checksum="FB373A9C9C376401" modified="2015-07-22" version="1">MRHYEVMVILDPDLEERAVSPLIESFLSVIREAKGKVEKVDTWGRRRLAYEIKKKPEGIYSVIDIQAEADVVKELDRQMNLNESVLRTKVLRPAIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N837</accession>
    <name>A0A0F7N837_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Caunorubicin/doxorubicin resistance ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_16675</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016879.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH83574">
        <property type="protein sequence ID" value="AKH83574"/>
        <property type="gene ID" value="AA958_16675"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_16675"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3509"/>
    <dbReference type="OrthoDB" id="1926714at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043215">
        <property type="term" value="P:daunorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900753">
        <property type="term" value="P:doxorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005894">
        <property type="entry name" value="DrrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01188">
        <property type="entry name" value="drrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="10"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="42"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH83574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="332" mass="34475" checksum="DCF5D7C7BB5648C8" modified="2015-07-22" version="1">MTNDPSGLAIETSGLVKVFGETRAVDGVDLAVPRGTVYGVLGPNGAGKTTTVKMLATLLRPDGGEARIFGKDVVRDANAVRSRVSLTGQYASVDEDLTGTENLVLLGRLLGHRPAAARVRAAQLLEAFGLSEAAAKQVKNYSGGMRRRIDIAASILNTPDLLFLDEPTTGLDPRSRNQVWDIVRAVVAQGTTVLLTTQYLDEADQLASRIAVIDHGKVIAEGTKGELKASVGAGSVHLRLRDAAQRAEAVALLETALAGAQVQLEPDPVALTARVGNGDGSAAAAQAAAALAELARADITVDNFSLGQPSLDEVFLALTDRPAGAETQEAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N891</accession>
    <name>A0A0F7N891_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">UDP-N-acetylenolpyruvoylglucosamine reductase</fullName>
            <ecNumber evidence="17">1.3.1.98</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">UDP-N-acetylmuramate dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">murB</name>
        <name evidence="19" type="ORF">AA958_20985</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 17">Cell wall formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 17">
            <text>NADP(+) + UDP-N-acetyl-alpha-D-muramate = H(+) + NADPH + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine</text>
            <dbReference type="Rhea" id="RHEA:12248"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:68483"/>
            <dbReference type="ChEBI" id="CHEBI:70757"/>
            <dbReference type="EC" id="1.3.1.98"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 17">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 17">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 17">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 17">Belongs to the MurB family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.98" evidence="17"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017541.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_20985"/>
    <dbReference type="EnsemblBacteria" id="AKH84256">
        <property type="protein sequence ID" value="AKH84256"/>
        <property type="gene ID" value="AA958_20985"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_20985"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4422"/>
    <dbReference type="OrthoDB" id="841869at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008762">
        <property type="term" value="F:UDP-N-acetylmuramate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.78.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00037">
        <property type="entry name" value="MurB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003170">
        <property type="entry name" value="MurB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011601">
        <property type="entry name" value="MurB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036635">
        <property type="entry name" value="MurB_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21071">
        <property type="entry name" value="PTHR21071"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02873">
        <property type="entry name" value="MurB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56194">
        <property type="entry name" value="SSF56194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00179">
        <property type="entry name" value="murB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15 17" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8 17" id="KW-0132">Cell division</keyword>
    <keyword evidence="12 17" id="KW-0133">Cell shape</keyword>
    <keyword evidence="16 17" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7 17" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 17" id="KW-0274">FAD</keyword>
    <keyword evidence="9 17" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11 17" id="KW-0521">NADP</keyword>
    <keyword evidence="14 17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13 17" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="18">
        <location>
            <begin position="17"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="active site" evidence="17">
        <location>
            <position position="160"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="17">
        <location>
            <position position="239"/>
        </location>
    </feature>
    <feature type="active site" evidence="17">
        <location>
            <position position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00010485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="AKH84256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="351" mass="36411" checksum="5DFC31FDDE80259C" modified="2015-07-22" version="1">MQVRHDAPLAPLTTLRLGGPAARLVTATTDAEVVEAVRAADTAGTPLLVVGGGSNLVVSDAGFPGTALRIATTGFDLDGTALELAAGENWSDAVARTVDAGLAGVECLAGIPGSAGATPIQNVGAYGQEVAETITEVVAYDRTTGETVTVSGADCGFSYRHSRFKADPDRFVVLRVRFRLADEGGLSAPIRYGETARMLGVAPGERVPAAQARDAVLKLRAGKGMVLDPEDHDTWSAGSFFTNPILDERAHAAFLARVADRLGPDARPPAFPAGEGRTKTSAAWLIDHAGFTRGYGTGPARISSKHTLALTNRGSATTEDLLALAREVRDGVRDAFGVTLVNEPVTVGVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8T3</accession>
    <name>A0A0F7N8T3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Biotin--[biotin carboxyl-carrier protein] ligase</fullName>
            <ecNumber evidence="2">6.3.4.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_22230</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.3.4.15" evidence="2"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017722.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_22230"/>
    <dbReference type="EnsemblBacteria" id="AKH84461">
        <property type="protein sequence ID" value="AKH84461"/>
        <property type="gene ID" value="AA958_22230"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_22230"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4682"/>
    <dbReference type="OrthoDB" id="1842956at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004077">
        <property type="term" value="F:biotin-[acetyl-CoA-carboxylase] ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd16442">
        <property type="entry name" value="BPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004408">
        <property type="entry name" value="Biotin_CoA_COase_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003142">
        <property type="entry name" value="BPL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02237">
        <property type="entry name" value="BPL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03099">
        <property type="entry name" value="BPL_LplA_LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00121">
        <property type="entry name" value="birA_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0092">Biotin</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="3">
        <location>
            <begin position="26"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH84461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="288" mass="29944" checksum="BE254E824C314FD9" modified="2015-07-22" version="1">MSADRGSRWSDLDRPPLNADALRRALVRAGGLWTSLDVVEATGSTNADLAARAREGAAEGAVLVAEEQTAGRGRLDRRWSAPPRSGLFFSVLLRPEGVPVSRWGWLPLLAGVAVATALPRAAGVDTALKWPNDVLVTVEGEERKAGGILVERPDAASESVVLGIGINVTLRADELPVPQAGSLALAGAKVTDRDPLLRAMLRSLERWYGSWRTAGGDPAGARLQETYAAGCATLGRQVRAELPGGTAVTGEAVAVDGDGRLVLATAAGLAEPVSAGDVVHLRSADEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8Z5</accession>
    <name>A0A0F7N8Z5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_18745</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017196.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_18745"/>
    <dbReference type="EnsemblBacteria" id="AKH83899">
        <property type="protein sequence ID" value="AKH83899"/>
        <property type="gene ID" value="AA958_18745"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_18745"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3931"/>
    <dbReference type="OrthoDB" id="633575at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH83899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="1192" mass="128938" checksum="DA9BF10429808719" modified="2015-07-22" version="1">MTTATSTRIPRAPSNSAPQFPAGIELVGSQMRSTNLERDVEDALHAPYVGARAIDVLERIASALADQRRTRAWSFTGPYGSGKSTLSNIVDALLGRDAKRRSEAERILEDASPALAQRLAAARDAVAPHGFLGGVATARRESVVATLSRALHTATARRWGKRVPKPVATALEACADPNQAGANEILGAVTALTAHTQQPLLLVIDEFGKTLEHLAGHNEFADAQHDLFLLQELAEKAAGPNGLPVYLMTLQHLSFMDYASRSSEMKTREWAKIQGRFEDITFVPHHGDSLHLLRRRLDRSAVNAAGQDLINACAETSADIWTQHGLGVLADLGPEHFADLYPLHPITALAAPILAAQIGQHDRSLSGFLNSGEPNTVRHSLAQHSNENAEHASTVRLPQLYDYFLNSGRTTLLVSANASRLIEVDSRIRDANGLPDADQDVLKTIGVLNLIDSDGALSATAPMIHFALHDPADVADPDAFTALEERLADLVRRGFVVHREFSGEYRVWQGTDVDIDGRLKDISSHLNDAAVINRLDSLVPQAFVASRHSQVTGMMRVFYTAVSGPETKTVAAPDELREPADGLVVFHFGTDADRPTVHSPLPVLVGTTPDPGAVLATATYVVALKELSVQQDIDHVARREVMERLVLAEAELLELLQDRFYPPSSDASWSLWHTGIAPGEEPGASDLTARSLSGLVSLACESVYPDTPHIRNEMLGRHVLTSQAAQARGILLTAMLSASGEENLGLSGYKAERAIYHGVLAYLGLHRENGAVQAESRQESLLPYGFSPPGDGHEHAQPAWNALNEVLTGATERVSMEEVIRVLMSPPFGLKAGVVPVFLIPALIIRRHDVALFEEGTYLPRLTIDVVERIVKGPARFSVKYTPAGDGQRGSIIKKLMVSLGVEAPRSKALRNPDLLSVASALIMRVADLHKYARSTKSISADARIVRTTIAGALDPDDLIFHALPRALDLPEIPARTRANAEAANTYVERLTAAADELVAIDGELRAQVVRVLAKEFRLPTELPELRAQLAARLRGFADAVLAPELRGFVDFVLSDDLEADEWLEPIVVRLTNSALGDWDDHEVKVFPQKARAMAAALDRVGHLHHAGNEVDVREEKLDAQLLTLTDSAGVEQRTLIYVPEQARGEANSLAADVLKQAVKALGPDGARILLAALAQRVTDAATAASERKAQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9B5</accession>
    <name>A0A0F7N9B5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_26130</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018366.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_26130"/>
    <dbReference type="EnsemblBacteria" id="AKH85125">
        <property type="protein sequence ID" value="AKH85125"/>
        <property type="gene ID" value="AA958_26130"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_26130"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5501"/>
    <dbReference type="OrthoDB" id="1488093at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="172"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="82"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH85125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="306" mass="33561" checksum="9BF98B9C1D6F2C56" modified="2015-07-22" version="1">MTALAAPPEAKPDAPGPPPPRRRLTPYWLLLPAALWLLVFFAAPLVYQASTSVQSGSFEEGFEVTWRWANYTDALDQYAEHFARSFGYAAVATVLCLAIGYPLAYMIAFRAGRWRGVLLVLVIAPFFTSFLIRTLAWKTILSDNGPLVGALDTLHVLDVTATLGLTTDDRLLATPLAVVCGLTYNFLPFMILPLYTSLERIDPGLHEAAQDLYARPLTVFRRVTFPLSMPGVVAGTLLTFIPASGDYINAQLLGSPKEQMVGNAIQKQFLNVLDYPTAAAMSFLLMAAILIMVTVYIRRAGTEELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9L9</accession>
    <name>A0A0F7N9L9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Patatin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_26775</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018477.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_26775"/>
    <dbReference type="EnsemblBacteria" id="AKH85240">
        <property type="protein sequence ID" value="AKH85240"/>
        <property type="gene ID" value="AA958_26775"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_26775"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5633"/>
    <dbReference type="OrthoDB" id="373926at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="1 2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="3">
        <location>
            <begin position="8"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="2">
        <location>
            <begin position="12"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="2">
        <location>
            <begin position="163"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="43"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH85240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="317" mass="35007" checksum="E5D821E29E60BCC2" modified="2015-07-22" version="1">MDDLKIGLAVEGGGIRGVVSAAMLCALEDCGLNQAFDTIYSASSGAINSAYFLNGETWYPLSIYYDDLATRTFVDFRRVLRGRIMDLDYAFEVVDNVKPLGYEEVIASPTRLHVAVTLVDDIRTEAVTDFTSRADLRAALIASAWLPVALRGTADFRGSRAVDGGVLTPHPYKLALADGCTHVLSLSTRPIQPPAQKLSVSQRWAIRHLDRIRDGLGRGYGEAIERYRDERVMLQRRMTEPGEAPYVLDLAPLSWMPQVKRHELDPGRIIGGARGGYEVMYCAVEGKDPALIKNGRIRAVPQLTIVTKDDANNRQRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9R5</accession>
    <name>A0A0F7N9R5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_24170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_24170"/>
    <dbReference type="EnsemblBacteria" id="AKH84796">
        <property type="protein sequence ID" value="AKH84796"/>
        <property type="gene ID" value="AA958_24170"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_24170"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5093"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH84796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="1336" mass="146515" checksum="0AC0A35924D9BFBB" modified="2015-07-22" version="1">MARVVGDLPGEPDRAHLSSGYRISDRLILTTAHELAHTTALAADLGGEGTYRPVTCVWRGGTMDLALLRFDTAPATRVPPVRLGSVPRDREAEVAARAVGHPRWAQVDRRTAGEPDAVWRGRTGVRCAIRTADAEAPGLLRVGVKDAAPAPAPAGESPWQGMSGAAVRTEESGLLVGVVTDHVPAAGVGMLQVTALDSVDDDEWRALLGDEDVDPRPLPVLPDGWRRTRAVQQHHVRMDRIRRTPQPLVPEKLPYVDPGGAAAPAAVLDRLAGMAASPGLPAGVLVVGEPGAGKTRLCLETAALAEDSREWLVVHVTAAAPLTDVWDSVDGQADRVLVVADDVDRIASPGEKYTEVFREAAGAGVRLAVLTTVRRARLDALKDDPLTPYQTFETLDIRWDPSYHRAISREMVRSSLASEAGRQLDEDRLVGLCAGPPAVSQLCAVYYDSLARAGSDLTGVPPRPDREFSIWLRDILHGMKLPAVPADGDPDPATTAVAQLVVHAPRPFKEALDIFAPGRDDPRRTAGAETIGSLVTGGLLYAQDDALRPAHDVYADGLLGHAVLTAGQRTVHPRGLRLVLETGLADGRALVRVATAVDRLRDTLDVAAGDKLAGVVGEWGDDRRTALRELVLADPKGRELRALLALPTWRPVAVRRLAEPWLEEHHTEIRARDTVLTAARYLPAALANRYLFDWIYDHAHRPQAALAFQQALENDDLDPAVLEWTTDQVYEWLTQNAPRLSACRPLQRILDTSRNGLPPEDPRVGQVLTWALRWLRRYGTRREAGFVARPLVLHPELKGADLTRTARLLLDSVAPDDPPSATFALEAVLARHRLHRDLDRGVYEQAVADSFAWLADDAGYGLRRTAAYLLKELVVPGLPGRDGLARAVQAAWIWLEPNAGHHVEMGKVLPGLLKNAAKSRPGQHAAFVREEREELGRLAMDWLEAHEDSGRNSGSEVLGALLGTPLPDGDPERLRWLVDEALVMLGDRPAPSVARSVLAPLLYKRYADKDLRDRVVAATYAQLPPAAPPSRHMAFPLTKLVERTDLGEAEHERAMTGTLEWLNRYPRASGAPALLAEALRSRRTTPGDRVRLAARAVGMLTPRTLLPERKGKEPRLPRALLTYRADTPTEWNRFVARACDLLTDEKQPREAVRVLRVLLAGADRLDGPVLTRLHRTCLDWCEVHDHTDRAFSLLIPALDNRALPPDVRRRASRLAVRRLRPGGERNSAHGNLLESLLRSGELPDADEVDRVLEAALDWLEAHRSDHAAVDPLLVQVARWLERPAGTHRTEARLRRAMVRIGTWLDDRQDGAPERREALDNHRQRLAALLDRGGEAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9W1</accession>
    <name>A0A0F7N9W1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rplE</name>
        <name evidence="9" type="ORF">AA958_21235</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uL5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017572.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_21235"/>
    <dbReference type="EnsemblBacteria" id="AKH84298">
        <property type="protein sequence ID" value="AKH84298"/>
        <property type="gene ID" value="AA958_21235"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_21235"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4472"/>
    <dbReference type="OrthoDB" id="1456375at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01333_B">
        <property type="entry name" value="Ribosomal_L5_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002132">
        <property type="entry name" value="Ribosomal_L5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020930">
        <property type="entry name" value="Ribosomal_L5_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031309">
        <property type="entry name" value="Ribosomal_L5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022803">
        <property type="entry name" value="Ribosomal_L5_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031310">
        <property type="entry name" value="Ribosomal_L5_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11994">
        <property type="entry name" value="PTHR11994"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00281">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00673">
        <property type="entry name" value="Ribosomal_L5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002161">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55282">
        <property type="entry name" value="SSF55282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="5" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L5" evidence="7">
        <location>
            <begin position="35"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L5_C" evidence="8">
        <location>
            <begin position="95"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH84298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="191" mass="21340" checksum="D0CCFC99EEC6A4E4" modified="2015-07-22" version="1">MTATTATAAGTPPRLKQRYRDEIQAKLKDEFSYENVMQIPGLTKIVVNMGVGDAARDSKLIEGAIKDLATITGQKPSVTKARKSIAQFKLREGMPIGAHVTLRGDRMWEFLDRLLSLALPRIRDFRGLSPKQFDGRGNYTFGLTEQVMFHEIDPDKIDRVRGMDITVVTTASNDDEGRALLRLLGFPFKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAE6</accession>
    <name>A0A0F7NAE6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">IclR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_28450</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_28450"/>
    <dbReference type="EnsemblBacteria" id="AKH85520">
        <property type="protein sequence ID" value="AKH85520"/>
        <property type="gene ID" value="AA958_28450"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_28450"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5995"/>
    <dbReference type="OrthoDB" id="370329at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
            <begin position="16"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="4">
        <location>
            <begin position="78"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH85520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="263" mass="27669" checksum="7D3B26B5AB08F598" modified="2015-07-22" version="1">MPRSTDEPRPPAGGGVQSLERAFDLLERMADAGGEVGLSELAGSSGLPLPTIHRLMRTLVATGCVRQQPNRRYALGPRLIRLGESASRLLGTWARPHLARLVEETGETANMALLDGDEVVYVAQVPSRHSMRMFTEVGRRVLPHSTGVGKALLAHLPDGEVRALLARTGMPAATEKTITSADVFLKALAAVRADGYAVDDNEQEMGVRCLAVAVPDAPTAAAVSISGPAGRVTEAATERIVPVLQEVARELSAALTDATAGAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAK2</accession>
    <name>A0A0F7NAK2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Protein often found in actinomycetes clustered with signal peptidase and/or RNaseHII</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_25965</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018337.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_25965"/>
    <dbReference type="EnsemblBacteria" id="AKH85096">
        <property type="protein sequence ID" value="AKH85096"/>
        <property type="gene ID" value="AA958_25965"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_25965"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5467"/>
    <dbReference type="OrthoDB" id="1837954at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019592">
        <property type="entry name" value="DUF2469"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10611">
        <property type="entry name" value="DUF2469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH85096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="105" mass="12655" checksum="6902E25F873E3F1F" modified="2015-07-22" version="1">MSAEDLEKYETEMELKLYREYRDVVGLFKYVIETERRFYLTNDYEMQVHSVQGEVFFEVSMADAWVWDMYRPARFVKQVRVLTFKDVNVEELSKSDLEMPSDDLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAP9</accession>
    <name>A0A0F7NAP9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">1-deoxy-D-xylulose 5-phosphate reductoisomerase</fullName>
            <shortName evidence="7">DXP reductoisomerase</shortName>
            <ecNumber evidence="7">1.1.1.267</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">1-deoxyxylulose-5-phosphate reductoisomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">2-C-methyl-D-erythritol 4-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">dxr</name>
        <name evidence="12" type="ORF">AA958_26245</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>2-C-methyl-D-erythritol 4-phosphate + NADP(+) = 1-deoxy-D-xylulose 5-phosphate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:13717"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
            <dbReference type="ChEBI" id="CHEBI:58262"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.267"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 1/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DXR family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.267" evidence="7"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018387.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_26245"/>
    <dbReference type="EnsemblBacteria" id="AKH85146">
        <property type="protein sequence ID" value="AKH85146"/>
        <property type="gene ID" value="AA958_26245"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_26245"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5524"/>
    <dbReference type="OrthoDB" id="1200722at2"/>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00092"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030604">
        <property type="term" value="F:1-deoxy-D-xylulose-5-phosphate reductoisomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00183">
        <property type="entry name" value="DXP_reductoisom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003821">
        <property type="entry name" value="DXP_reductoisomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013644">
        <property type="entry name" value="DXP_reductoisomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013512">
        <property type="entry name" value="DXP_reductoisomerase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026877">
        <property type="entry name" value="DXPR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036169">
        <property type="entry name" value="DXPR_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30525">
        <property type="entry name" value="PTHR30525"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08436">
        <property type="entry name" value="DXP_redisom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02670">
        <property type="entry name" value="DXP_reductoisom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13288">
        <property type="entry name" value="DXPR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006205">
        <property type="entry name" value="Dxp_reductismrs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69055">
        <property type="entry name" value="SSF69055"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00243">
        <property type="entry name" value="Dxr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 7" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 7" id="KW-0521">NADP</keyword>
    <keyword evidence="5 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DXP_reductoisom" evidence="9">
        <location>
            <begin position="26"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="DXP_redisom_C" evidence="10">
        <location>
            <begin position="170"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="DXPR_C" evidence="11">
        <location>
            <begin position="286"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="29"/>
            <end position="58"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AKH85146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="419" mass="44184" checksum="1BECF8C66AE145B6" modified="2015-07-22" version="1">MTETSAAPLADPHLRPATADDGPREIVILGSTGSIGTQAIDIVLRNPDRFRVTALSAAGGRVELLAEQAHKLRVRRVAVARAGKAGELREALAARYGAGEPLPEVLAGPDAATEVAADECHTVLNGITGSIGLAPTLAALKAGRMLALANKESLIVGGPLVKEVARHGQIVPVDSEHSALYQALLGGTRGEVRKLLVTASGGPFRGRTREELTEVTPEQALAHPTWDMGPVVTINSSTLVNKGLEVIEAHLLYDVPFDRIEVVVHPQSYVHSMVEFTDGSTLAQASPPDMRMPIALALGWPDRVPDAAPAFDWSAAATWEFFPLDEKAFPSVPLACHVGALGGTAPAVFNAANEECVDGFLTGKLPFLGIMDTVSQVVAEHGTDDPGTRLTVADVLEAETWARARARELAGLPADQHDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAX7</accession>
    <name>A0A0F7NAX7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Toxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_22970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
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    </dbReference>
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    <dbReference type="OrthoDB" id="1996962at2"/>
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        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="27"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="83" mass="9090" checksum="2978F1DCA7ACA76D" modified="2015-07-22" version="1">MSTRDLTWFKSSYSSSPDGDCIEVAVSWRKSSYSSGSQGDCVEVAACPSAVHVRDSKDKTGPQLTFSPDAWADFVAFARRHQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-12-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAZ4</accession>
    <name>A0A0F7NAZ4_9ACTN</name>
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        <submittedName>
            <fullName evidence="2">ArsR family transcriptional regulator</fullName>
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        <name evidence="2" type="ORF">AA958_29375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85670.1"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH85670">
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        <property type="gene ID" value="AA958_29375"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_29375"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6198"/>
    <dbReference type="OrthoDB" id="1800563at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
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        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
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    <dbReference type="InterPro" id="IPR036388">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HTHARSR"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="26"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="120" mass="12841" checksum="537EF883AE0578B7" modified="2015-07-22" version="1">MSNLRSSLMLDPSVEPCCPPLTERPYRAEEAEVAARMFKALGNPVRLRLFSAVASHEGGEACVCDISDVGVSPPTVSHHLKSLKEAGLLASERRGTWVYYRVEPGVLAAMGQALTAEAGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NB61</accession>
    <name>A0A0F7NB61_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_27370</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018570.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_27370"/>
    <dbReference type="EnsemblBacteria" id="AKH85336">
        <property type="protein sequence ID" value="AKH85336"/>
        <property type="gene ID" value="AA958_27370"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_27370"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5768"/>
    <dbReference type="OrthoDB" id="1254678at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="79"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="156"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="277"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="301"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="325"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="349"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH85336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="398" mass="39775" checksum="42FD7EA55F4BCFE6" modified="2015-07-22" version="1">MTDLARATAPAAGGGTSKGIRFGKRPARQPADGEILRLGQVLGRTSGGIPVLLVLAFALTMSTESFLTGTNLDNLGRQVSIFAIIAVGQLIVILTAGIDLSVGSVVGLSGIVAAKVVYDTGGGLPIAGAVLLALLVGAAAGLINGLLVAFLKMPPFIVTLGMMGAARGATLLLSDGRTVQPLPDGFAEIGGGSLLGISHLTWLMVLITVFFALLLRRTIWGEYVYAVGSSAESARLTGVPVRRVLVSAYVLSGTLAAAAGVLLASRLGNGVPTSGNGYELQAIAACVIGGASLFGAKGSALGALVGALVVGMLNNGGTLLGIDPFWLQIVIGVLILAAVATEHVHNLRRGGKAKPVADAPPPGGPGEPVPAGGTAQPDRGTAGDETAGEPTPTKRAVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-12-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NB83</accession>
    <name>A0A0F7NB83_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ArsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_19135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH83952">
        <property type="protein sequence ID" value="AKH83952"/>
        <property type="gene ID" value="AA958_19135"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_19135"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4023"/>
    <dbReference type="OrthoDB" id="1772343at2"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF01022">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="17"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="125" mass="13390" checksum="27383FFEB89989D6" modified="2015-07-22" version="1">MSATRVPPAAQAPADPVACSHTDTVARFFRALADPTRLRLLEFVLDGERTAAECVAHVGITQPRVSVHLSCLVDCGYLVARRDGRKLLYSVGDPRTADLVVLARALAADNATALDCCTRIPRHPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NB92</accession>
    <name>A0A0F7NB92_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Transcriptional regulator WhiB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">whiB</name>
        <name evidence="14" type="ORF">AA958_19220</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="11">Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="11">The Fe-S cluster can be nitrosylated by nitric oxide (NO).</text>
    </comment>
    <comment type="PTM">
        <text evidence="11">Upon Fe-S cluster removal intramolecular disulfide bonds are formed.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the WhiB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017257.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_19220"/>
    <dbReference type="EnsemblBacteria" id="AKH83962">
        <property type="protein sequence ID" value="AKH83962"/>
        <property type="gene ID" value="AA958_19220"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_19220"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4041"/>
    <dbReference type="OrthoDB" id="1318467at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035731">
        <property type="term" value="F:dinitrosyl-iron complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01479">
        <property type="entry name" value="WhiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034768">
        <property type="entry name" value="4FE4S_WBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003482">
        <property type="entry name" value="Whib"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38839">
        <property type="entry name" value="PTHR38839"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02467">
        <property type="entry name" value="Whib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51674">
        <property type="entry name" value="4FE4S_WBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 11" id="KW-0408">Iron</keyword>
    <keyword evidence="6 11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 11" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="4Fe-4S Wbl-type" evidence="13">
        <location>
            <begin position="27"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="163"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AKH83962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="213" mass="23941" checksum="5F24EF1D0EAF772F" modified="2015-07-22" version="1">MRYITTHEAPASGLRGIADTSWHSRGACYGLDSVEADEVFFPPPRDHIAVAEAKELCALCPVRSDCLNYAVENGLREGIWGGLTEAERRPWHDGLPHRLDYRRVRAFFDGRDVHLTEAERQLVMDHAYLRGWRPDRLAAALQISHRHARDLLRQAALKVFDRDRTYGVPQPKRKRHKTSPAVDAPAPSRPRTRQPIARTAASTTASIPAGKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBB4</accession>
    <name>A0A0F7NBB4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">OmpR/PhoB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_30310</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AfsR/DnrI/RedD regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019028.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_30310"/>
    <dbReference type="EnsemblBacteria" id="AKH85800">
        <property type="protein sequence ID" value="AKH85800"/>
        <property type="gene ID" value="AA958_30310"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_30310"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6403"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15831">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03704">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH85800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="269" mass="29742" checksum="C4F283DECF0F635A" modified="2015-07-22" version="1">MEIQVLGTLLACENRVSVVPTAPKPRRALALLALHADQVVPVTVLIDELWGKNPPRSARSTLQTYILQLREMISRALATSPDELWTAKDIIATVPGGYRLATRGGTVDYREFERRTESGYRAMDTLDHSGAARHLGAALSLWSGPALTDIEAGPQIVMEAQRLEEARLCALEQRIEAELRLGRHRELLAELTVLVNQYRMHEHLHGQFMLALHRSGRRVEALNVYQRLRSTLVTELGLEPSGALSSLQRHILLSRTGTASAADDPLAVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBC9</accession>
    <name>A0A0F7NBC9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">2-alkenal reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_19560</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017300.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_19560"/>
    <dbReference type="EnsemblBacteria" id="AKH84007">
        <property type="protein sequence ID" value="AKH84007"/>
        <property type="gene ID" value="AA958_19560"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_19560"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4122"/>
    <dbReference type="OrthoDB" id="161217at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="PTHR19375"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="SSF100920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="612"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH84007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="833" mass="90353" checksum="C0312EA454527DB2" modified="2015-07-22" version="1">MSETIDYGIDLGTTNSAIAVAEDGGVRIVKNNEQWDYSPSAVYIPKKDIVHVGRRAKERTESDPANAHSEFKLEMGVAGAARRFERAGLSLTPEELSAEVLKSLRQDAAAETGYAPEVAVITVPAAFALNQNTATSEAAALAGLSEHCPLVQEPTAAAIAYGVQDTSDSAHWMVFDLGGGTFDAAVMSKRDGELQLIQHAGDPYLGGKLIDWAVVDDLLAPAVRRDLGLPDFNRSNRRWLGNFAKLKAEAENAKIALSRMDKIDIACDLDDGSGDTENFEFTLTRGALDDLALPFYTRAIKLCREALAESALRPDHIDRLLLAGGSTLSPGLRALLTDRYTGLGIEVDHSQDPTTVVARGAAAFARTVRRPRKVRAAAPGAFAVELNYPAQTVDTTDIPVSGKVTSGSTVDFTRYAVVLANPDGQPPFRGPRTALSQDGTFYTEVALTAGATSRFTVELTDTSGTRQKLAGGTLAITHAKVVPGEAVLTGTLGIGRADGSFDPLLRKGTTLPAMVTKIYRTTIPLHRSEPDAVIRIPLLEGERARAERNTRVGQLEIRPRDVRIDLPAESEVEVTFEIEASSREALVTAHIPLVQQQFEATINRTELRAPEQHELAGRLRDLEQRLRGLKDDAASEHAEQAGARLRKLEEHRPLTQLGREVEAADVDTGAAVTSERRMRDLEAELDDIEEAIEIPGLERRLWDVLGACEGIITQVGGTPADRRELENLRGRASAPDGDATPAELRKLVKRAEEFQVELLRRTDEWDFVVFNALVEMRDSMHPSHQAAAAIRDGRRAMAVGDRGAIAAVNQRLRRLLPPEAAGNELGRKEGGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBE7</accession>
    <name>A0A0F7NBE7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Na+:solute symporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AA958_24130</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018041.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_24130"/>
    <dbReference type="EnsemblBacteria" id="AKH84789">
        <property type="protein sequence ID" value="AKH84789"/>
        <property type="gene ID" value="AA958_24130"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_24130"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5085"/>
    <dbReference type="OrthoDB" id="231452at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="42"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="123"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="269"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="314"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="364"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="390"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="424"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="450"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="480"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH84789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="521" mass="55928" checksum="945940265D64DDB9" modified="2015-07-22" version="1">MSIADWIMVGAYFCVMVGIGWWSKNRIHTVKDFFTTGGRIPWWLSGISHHMSGYSAVMFVAFAAVAYDHGLTVYVWWALTIGLGIGIGAFLFAPRWARLRAKHDVASPLEYLAKRYNLPTQQVLAYSGALLKVVDIAAKWVAISVLLQGFADVPLEWGILFTGVATMAYMAVGGLWADVLTDFSQFLIQLLAGVVMFWAVLAELGGIDTLWTMWDDLPDSHHDPVTGPVTTTLVLAFLLVKTFEYNGGMWNLAQRYMAAPSGSAAKRSALLSSGLWLVWPFILFLPMFAAPLIVPGLENSEESYIELAKELMPAGLTGLVLAGFFCHTMAMVASDSNVISAVITRDMAPVLMPRVRQLTDRAQLTFARVTTVAFVSVSMVIAIATGGEGFVLDVVVDLVAATMGPISIPLMLGMLPWFRRCGPTAAIVSWAGGLGLWAVLHWVLDGTTQAALVGLPLLTSLVLYVGIGLLRPEGGAEQDALIDSLGSDPEEGAAAGNASPGTEAGAKDTQPPEATADLTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBF8</accession>
    <name>A0A0F7NBF8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NUDIX hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_28070</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018685.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH85451">
        <property type="protein sequence ID" value="AKH85451"/>
        <property type="gene ID" value="AA958_28070"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_28070"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5917"/>
    <dbReference type="OrthoDB" id="882626at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="4">
        <location>
            <begin position="3"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH85451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="160" mass="17684" checksum="BEC526BB45A23AA3" modified="2015-07-22" version="1">MRTPRRAARLAILDPDGAVFMFRYDDVEAGIHWATPGGGLDPGESPRAGAVRELHEETGWTDIVAGELLCTWEHDFTRQGVPVRQHEHIYLAAGPRREPTAEAVARHPEDRILGWKWWSPAEAAEPCEPLWPPPLARLLAAPRGGPVDLGYLPVAPSHRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBI6</accession>
    <name>A0A0F7NBI6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_28310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018730.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_28310"/>
    <dbReference type="EnsemblBacteria" id="AKH85496">
        <property type="protein sequence ID" value="AKH85496"/>
        <property type="gene ID" value="AA958_28310"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_28310"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5967"/>
    <dbReference type="OrthoDB" id="1984437at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="2"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="116" mass="12898" checksum="6F9B339BBE636D32" modified="2015-07-22" version="1">MSIRRVVPDIKTESFEASREFYERLGFEEVMNLGWVMALAAPGNPTAQLIFMERDASAPVEPDMSIEVADVDAAHEAMRAAGAEIVHPLTDEEWGVRRFFVRDPNGQVVNVVAHQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBY0</accession>
    <name>A0A0F7NBY0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_29720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018944.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_29720"/>
    <dbReference type="EnsemblBacteria" id="AKH85716">
        <property type="protein sequence ID" value="AKH85716"/>
        <property type="gene ID" value="AA958_29720"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_29720"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6274"/>
    <dbReference type="OrthoDB" id="1465613at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="5"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="376" mass="40609" checksum="9189591052EEF1BA" modified="2015-07-22" version="1">MTQKVRVAIAGLGFGAEFIPIYQAHPDAELAAVCQRTETALTQVADHFGVPGRFTSFDAMLRDPGIDAVHINTPIPEHAEHTVAALRAGKHVACTVPMATTLDECREIVAAVRESGRNYMMMETVVYSREFLHVRDLVANGTIGRVQFLRGAHYQEMAGWPGYWEGLPPMHYATHAVSPVLSLAGALAESVVCIGSGRISPRLAEKYGSPFAVESALITLRGTPVGAEIARSLFETAREYVESFTVFGSRASFEWEQTQGSGHVLHTGEEPKSIGIPDFGHRLPPQIAPFTTRGVYDDENEHLSFVQGGGHGGSHPHLAHEFIRSIVEERASAIDEVTAANWTSVGICAHASAMDGGARVAVPDYEELREQGSAAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBY8</accession>
    <name>A0A0F7NBY8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_25135</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018199.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_25135"/>
    <dbReference type="EnsemblBacteria" id="AKH84948">
        <property type="protein sequence ID" value="AKH84948"/>
        <property type="gene ID" value="AA958_25135"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_25135"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5297"/>
    <dbReference type="OrthoDB" id="1510342at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="218"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="261"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="93"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH84948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="301" mass="32288" checksum="901BF4EEF09A0B72" modified="2015-07-22" version="1">MPTSTLTRGTPPPGPPAPRRRGPRRGPGARRSSRRLAADLCLLLAALAFVLPLAWLLFSSVDADSGLTARPPTDVTWDNFDAVMTTDITFRPLLNSLILCGSATAITVVAAALAAYPLSRYSSRLNRPFMLTILFTTSLPITAIMVPVYGLFVQINLIDTMSGTAFFLASSQLPFAIWLMKNFMDGVPKVLEEAAWTDGASSMQALVRVILPLMGPGVVVVTVFSFIMMWGNFFVPFMLLLSPDQMPASVSIFELFGNMGSVVYGELAAFSILYSAPAVLLYVLIARRLGGGFALGGAVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBZ1</accession>
    <name>A0A0F7NBZ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LuxR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_25285</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018225.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_25285"/>
    <dbReference type="EnsemblBacteria" id="AKH84974">
        <property type="protein sequence ID" value="AKH84974"/>
        <property type="gene ID" value="AA958_25285"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_25285"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5329"/>
    <dbReference type="OrthoDB" id="930905at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="17"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="161"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH84974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="231" mass="24948" checksum="2FF826E826640721" modified="2015-07-22" version="1">MPDVTVERKFSAARPIRVFLVDDHEVVRRGLRDLLEAEPGIEVTGEAGTFAQALARGPALRPDVAVLDVRLPDGDGIGVCRELRSRMPELACLMLTSFDDDDALLDAIMAGASGYVLKQIKGGDLVSAVRTVASGQSMLDPATTARLMTNLRRDDVPSAPENEVLAGLSPRELDVLELIGEGLTNRQIGQRLYLSEKTVKNHISRLLAKLGVERRIQAAVLASRAHRPPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NC65</accession>
    <name>A0A0F7NC65_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">30S ribosomal protein S3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rpsC</name>
        <name evidence="13" type="ORF">AA958_21205</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8 10">Belongs to the universal ribosomal protein uS3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017568.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_21205"/>
    <dbReference type="EnsemblBacteria" id="AKH84292">
        <property type="protein sequence ID" value="AKH84292"/>
        <property type="gene ID" value="AA958_21205"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_21205"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4466"/>
    <dbReference type="OrthoDB" id="1132353at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.32">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01309_B">
        <property type="entry name" value="Ribosomal_S3_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004044">
        <property type="entry name" value="KH_dom_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005704">
        <property type="entry name" value="Ribosomal_S3_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001351">
        <property type="entry name" value="Ribosomal_S3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036419">
        <property type="entry name" value="Ribosomal_S3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018280">
        <property type="entry name" value="Ribosomal_S3_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07650">
        <property type="entry name" value="KH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00189">
        <property type="entry name" value="Ribosomal_S3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54821">
        <property type="entry name" value="SSF54821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01009">
        <property type="entry name" value="rpsC_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50823">
        <property type="entry name" value="KH_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00548">
        <property type="entry name" value="RIBOSOMAL_S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 8 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 8 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 8" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="KH type-2" evidence="12">
        <location>
            <begin position="38"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="216"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="234"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AKH84292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="286" mass="31197" checksum="76C531F6035B1883" modified="2015-07-22" version="1">MGQKVNPHGFRLGITTDFKSRWYADKLYKDYIKEDVAIRRMMTQGMERAGISKVEIERTRDRVRVDIHTARPGIVIGRRGAEADRIRGDLEKLTGKQVQLNILEVKNPETDAQLVAQAVAEQLSSRVSFRRAMRKSMQSAMKAGAKGIKIQCGGRLGGAEMSRSEFYREGRVPLHTLRANVDYGFFEARTTFGRIGVKVWIYKGDVKNIAEVRAENAAARAGNRPSRGGGGGGDRPRRGGERGGRGRRPQREQQQAPAAEAPRAEAAGTAAGSAAGSATDSTGTEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NC84</accession>
    <name>A0A0F7NC84_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">30S ribosomal protein S11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rpsK</name>
        <name evidence="10" type="ORF">AA958_21305</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the universal ribosomal protein uS11 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018834824.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_21305"/>
    <dbReference type="EnsemblBacteria" id="AKH84312">
        <property type="protein sequence ID" value="AKH84312"/>
        <property type="gene ID" value="AA958_21305"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_21305"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4486"/>
    <dbReference type="OrthoDB" id="1713391at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01310">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001971">
        <property type="entry name" value="Ribosomal_S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019981">
        <property type="entry name" value="Ribosomal_S11_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018102">
        <property type="entry name" value="Ribosomal_S11_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036967">
        <property type="entry name" value="Ribosomal_S11_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11759">
        <property type="entry name" value="PTHR11759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00411">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002131">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03632">
        <property type="entry name" value="uS11_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00054">
        <property type="entry name" value="RIBOSOMAL_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 7 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="8"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AKH84312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="134" mass="14371" checksum="F07A52220D57A999" modified="2015-07-22" version="1">MPPKSRAAGAKKVRRKEKKNVAHGHAHIKSTFNNTIISITDPSGNVISWASAGHVGFKGSRKSTPFAAQMAAESAARRAQEHGMRKVDVFVKGPGSGRETAIRSLQATGLEVGSIQDVTPTPHNGCRPPKRRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCH8</accession>
    <name>A0A0F7NCH8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">4-hydroxy-tetrahydrodipicolinate synthase</fullName>
            <shortName evidence="9">HTPA synthase</shortName>
            <ecNumber evidence="4 9">4.3.3.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">dapA</name>
        <name evidence="11" type="ORF">AA958_26425</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 9">Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>L-aspartate 4-semialdehyde + pyruvate = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:34171"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:67139"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="4.3.3.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer; dimer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the DapA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.</text>
    </comment>
    <dbReference type="EC" id="4.3.3.7" evidence="4 9"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018419.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_26425"/>
    <dbReference type="EnsemblBacteria" id="AKH85179">
        <property type="protein sequence ID" value="AKH85179"/>
        <property type="gene ID" value="AA958_26425"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_26425"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5563"/>
    <dbReference type="OrthoDB" id="1438588at2"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00017"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008840">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00950">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00418">
        <property type="entry name" value="DapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005263">
        <property type="entry name" value="DapA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020625">
        <property type="entry name" value="Schiff_base-form_aldolases_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020624">
        <property type="entry name" value="Schiff_base-form_aldolases_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="PTHR12128"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00674">
        <property type="entry name" value="dapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00665">
        <property type="entry name" value="DHDPS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00666">
        <property type="entry name" value="DHDPS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="9 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 9" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0704">Schiff base</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="9">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <feature type="site" description="Part of a proton relay during catalysis" evidence="9">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <feature type="site" description="Part of a proton relay during catalysis" evidence="9">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012086"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR001365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AKH85179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="299" mass="31263" checksum="96F03D0A3A931CCE" modified="2015-07-22" version="1">MAPTSTPQTPFGRMLTAMVTPFTPAGALDLDGAQRLAAHLVDAGNDGLVLNGTTGESPTTSDAEKAQLVRAVVDAVGDRAHIVAGASTNDTRHSVELARAAQDAGAHGLLAVTPYYSKPPQQGLYAHFTAIADATDLPVMLYDIPGRSGVPINTETMVRLAEHPRIVANKDAKGDLGRASWAIAQTGLAWYSGDDMLNLPLLSVGGVGFVSVVGHLVTPELVALIEAYTGGDVAKATELHQQLLPVYTGMFRTQGVITVKAALTLRQMPGGPLRLPLVGLSPEETEQLKRDLKGGGVHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCT7</accession>
    <name>A0A0F7NCT7_9ACTN</name>
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        <submittedName>
            <fullName evidence="4">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_22630</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84532.1"/>
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    <dbReference type="EnsemblBacteria" id="AKH84532">
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        <property type="gene ID" value="AA958_22630"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_22630"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4761"/>
    <dbReference type="OrthoDB" id="1213601at2"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0016021">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="58"/>
            <end position="83"/>
        </location>
    </feature>
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        <location>
            <begin position="81"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH84532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="313" mass="33475" checksum="76D37EDC74C251C0" modified="2015-07-22" version="1">MTDQQPHDQHAPDMPAPPVAERQANSIGGALALVLGLAGALAGAGLLALGIALGGDGILAAGIPVLVLGALLFLAALVAMAGLNMVEPGEARVVQLFGRYTGTIRDDGLRWVNPLTTRRKISTRVRNHETAVLKVNDARGNPIELAAVVVWQVEDTAQAVFAVDDFTEFVATQTETAVRHIAIEYPYDAYEDDELSLRTDAEEITEKLAEELTARVQAAGVRIIESRFTHLAYAPEIASAMLQRQQAGAVVAARREIVDGAVGMVEDALARLTREDIVELDEERRAAMVGNLMVVLCGDRAPQPVLNTGSLYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCX3</accession>
    <name>A0A0F7NCX3_9ACTN</name>
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        <submittedName>
            <fullName evidence="2">Protein mbtH</fullName>
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    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_31895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
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        <lineage>
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        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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    <dbReference type="EnsemblBacteria" id="AKH86056">
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    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_31895"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6736"/>
    <dbReference type="OrthoDB" id="2067093at2"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="MLP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38444">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00923">
        <property type="entry name" value="MbtH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160582">
        <property type="entry name" value="SSF160582"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MbtH" evidence="1">
        <location>
            <begin position="3"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="76" mass="8779" checksum="BED2650E483756CE" modified="2015-07-22" version="1">MANPFDNENGTFLVLVNDENQHSLWPAFAEVPAGWKSVFGEESRKACMDYIEENWTDMRPKSLIDEMDRQEQAAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCY6</accession>
    <name>A0A0F7NCY6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nitrite reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_22960</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017844.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_22960"/>
    <dbReference type="EnsemblBacteria" id="AKH84587">
        <property type="protein sequence ID" value="AKH84587"/>
        <property type="gene ID" value="AA958_22960"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_22960"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4837"/>
    <dbReference type="OrthoDB" id="323168at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006657">
        <property type="entry name" value="MoPterin_dinucl-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04879">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01568">
        <property type="entry name" value="Molydop_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00926">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51669">
        <property type="entry name" value="4FE4S_MOW_BIS_MGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="2 4" id="KW-0408">Iron</keyword>
    <keyword evidence="3 4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S Mo/W bis-MGD-type" evidence="5">
        <location>
            <begin position="19"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH84587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="727" mass="77162" checksum="9CD96ED32C96B7DE" modified="2015-07-22" version="1">MSSGSSRAPYSPTPLPPPGPAVHTHCPYCALQCGTRLRPGATPAEPLSVEPDADFPVNQGGLCQKGWTAPAVLRAQDRLRTPLVRDRTGRLAPAGWVTALDTVAARLAEIRAAHGPDSVAVFGGGGLTNEKAYLLGKFARVALGTRMIDYNGRFCMSSAAAAGIAAFGLDRGLPFPVTDLGEADTVLLAGANPAETMPPLMRHLNKAGALVVIDPRRTATAERAALHLAPAPGTDLALALGLLHIAVTEGRHDEEYVEARTVGFRAAWRRAAGWWPERVELVTGVPADAQREAVWLLSEARRAYVLSGRGAEQHSKGTDTVAAFVNFALALGLPGRPGSGYGCLTGQGNGQGGREHGQKADQLPGYRHITDPGARAHVAGVWGVPPESLPGPGLSAAELLNALGTADGPRALLVFGSNPVVSAPDADRVQRRLAELDLLVVADFVPSETAAMADVVLPVTQWAEEEGTLTSLEGRVLRRHRALTPPPGVRTDLAVLHELAVRLGEPPDRFPAEPRRVFDELRRASGGGTADYGGVSYDRLDAGEALHWPCPATPEGSPPHPGTPRLFLDRFAHPDGKARFQDVDHREPADARDDRFPLWATTGRQLAHYQSGAQTRRVPELVRAAPEAIVEIHPDTAARAGLAEGELARVRSPRGAVLARVRLVATLRTDTVFLPFHFPGHGRANLLTGTALDPRSRMPEFKVSAVSVESVGLPERVREPAVRGATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7ND03</accession>
    <name>A0A0F7ND03_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptide ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_23140</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017874.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_23140"/>
    <dbReference type="EnsemblBacteria" id="AKH84617">
        <property type="protein sequence ID" value="AKH84617"/>
        <property type="gene ID" value="AA958_23140"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_23140"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4878"/>
    <dbReference type="OrthoDB" id="162819at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519415" evidence="2">
        <location>
            <begin position="20"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="3">
        <location>
            <begin position="81"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH84617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="545" mass="59359" checksum="D93B0595749DD0EB" modified="2015-07-22" version="1">MRRATRASWTACVVCAALAAAGCGSDSGDGGSSGGGSTFTAQWGDPQNPLEPANTNEVQGGKVLKLITRGLVVYDPKTAEPKNMLAQSIKSDDQKNWTVKVKKGFRFSNGEPVTARSFVDAWNYAANIKNRQVNATFFRYIDGYDKVHPTAEGSEPSARKLSGLKVVDDRTFTVKLSQKFSVWPDTLGYPAFAPLPKAFFDNHAAWLDKPIGNGPYKIESYNKGTSMKLVKDGTYKGDDKAKNDGVELKVYTDQNTAFTDLQAGNLDISDELPAGQLANAKNDLGDRFINQKAGIIQTLAFPLYDDAWGGRDNVDLRRGISKAIDREQITKQIYDDTRIPAKDWTSPVIGAKGGFDDTICGDLCAYDPKRAKKLIDGAGGLPGGKVTISSNVDTGSHREWMDAVCNSINKALGKENACVVNPIGTFADFRTQVVDRSFKGPFRAGWQMDYPLIENFLAPTYLTGASSNDAEYSNKKFDDLINQANAAGSTSEAVKKYKDAERLLAKDVPAIPLWYQNGIAGHSERVSDVFLDPFSVPSYPDVKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDC6</accession>
    <name>A0A0F7NDC6_9ACTN</name>
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        <submittedName>
            <fullName evidence="2">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_27570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018602.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_27570"/>
    <dbReference type="EnsemblBacteria" id="AKH85368">
        <property type="protein sequence ID" value="AKH85368"/>
        <property type="gene ID" value="AA958_27570"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_27570"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5809"/>
    <dbReference type="OrthoDB" id="913949at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="27"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="282" mass="31535" checksum="5EBE706031E21063" modified="2015-07-22" version="1">MGKVGNVSLYGGESEAADNLKTFGAMLKVLRDEAGLTQEALADGLGYSVEHISKIERGGRFPPRDLDKLAEEVLGPLAARLLRETRLSLTRKAGLASRFRHWAVIEQEALTLYAYECRTIPGLLQPEAYIRAVFEVVLPPLVEEQIEQRVAARLERQAVLDQRPNTFFGFILEQALLDRQMGGAEVARRLLDHLLATGERRNVEIQVMPRRMENHAGGDGSLYLAETVDHKWLGYSEGQRSSNLISDLADVGMLQQRYRKLSSQALSHEATVDLLQQMRGDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDI1</accession>
    <name>A0A0F7NDI1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Riboflavin synthase subunit alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_33345</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019526.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_33345"/>
    <dbReference type="EnsemblBacteria" id="AKH86301">
        <property type="protein sequence ID" value="AKH86301"/>
        <property type="gene ID" value="AA958_33345"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_33345"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.7042"/>
    <dbReference type="OrthoDB" id="1276859at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00402">
        <property type="entry name" value="Riboflavin_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001783">
        <property type="entry name" value="Lumazine-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026017">
        <property type="entry name" value="Lumazine-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21098">
        <property type="entry name" value="PTHR21098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00677">
        <property type="entry name" value="Lum_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000498">
        <property type="entry name" value="Riboflavin_syn_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00187">
        <property type="entry name" value="ribE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51177">
        <property type="entry name" value="LUMAZINE_BIND"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="Lumazine-binding" evidence="2">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Lumazine-binding" evidence="3">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="repeat" description="Lumazine-binding" evidence="2">
        <location>
            <begin position="97"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="Lumazine-binding" evidence="3">
        <location>
            <begin position="97"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH86301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="205" mass="21538" checksum="705B07E4905EDA19" modified="2015-07-22" version="1">MFTGIVEELGEVVAVEELPDAARFRLRGPVVTEGARHGDSIAVNGVCLTVVDHEGAEFTADVMAETLDRSSLGGLGPGDRVNLERPTAVGGRLGGHLVQGHVDGTGEITARKTSDNWEVVTVSLPAGLSRYVVEKGSITVDGVSLTVVEAGPDFFTISLIPTTLALTTLGFKQPGDRVNLEVDIVAKYVERLVAPHAARADGARE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDP1</accession>
    <name>A0A0F7NDP1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 13">DNA primase</fullName>
            <ecNumber evidence="12">2.7.7.101</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">dnaG</name>
        <name evidence="17" type="ORF">AA958_08840</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12 13 14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12 13 14">Binds 1 zinc ion per monomer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Monomer. Interacts with DnaB.</text>
    </comment>
    <comment type="domain">
        <text evidence="12">Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12 13">Belongs to the DnaG primase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.101" evidence="12"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_08840"/>
    <dbReference type="EnsemblBacteria" id="AKH86625">
        <property type="protein sequence ID" value="AKH86625"/>
        <property type="gene ID" value="AA958_08840"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_08840"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1862"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990077">
        <property type="term" value="C:primosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003896">
        <property type="term" value="F:DNA primase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03364">
        <property type="entry name" value="TOPRIM_DnaG_primases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00974">
        <property type="entry name" value="DNA_primase_DnaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013264">
        <property type="entry name" value="DNA_primase_core_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037068">
        <property type="entry name" value="DNA_primase_core_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019475">
        <property type="entry name" value="DNA_primase_DnaB-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006295">
        <property type="entry name" value="DNA_primase_DnaG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013173">
        <property type="entry name" value="DNA_primase_DnaG_DnaB-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036977">
        <property type="entry name" value="DNA_primase_Znf_CHC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030846">
        <property type="entry name" value="DnaG_bac"/>
    </dbReference>
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        <property type="entry name" value="TOPRIM_DnaG_bac"/>
    </dbReference>
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        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002694">
        <property type="entry name" value="Znf_CHC2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10410">
        <property type="entry name" value="DnaB_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08278">
        <property type="entry name" value="DnaG_DnaB_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Toprim_4"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF08275">
        <property type="entry name" value="Toprim_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01807">
        <property type="entry name" value="zf-CHC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002811">
        <property type="entry name" value="DnaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00766">
        <property type="entry name" value="DnaG_DnaB_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00400">
        <property type="entry name" value="ZnF_CHCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01391">
        <property type="entry name" value="dnaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12 13" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 12 13" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 12 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2 12 13" id="KW-0639">Primosome</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 12 13" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 12 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 12 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 12 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Toprim" evidence="16">
        <location>
            <begin position="252"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CHC2-type" evidence="12 14">
        <location>
            <begin position="32"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="435"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR002811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR002811-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AKH86625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="642" mass="68979" checksum="FC3A8D83B31FDEC1" modified="2015-07-22" version="1">MRTVRNAVPIDAVVSEYLQLRPGGGGNLKGLCPFHDEKSPSFHVSPAKGLYHCFGCQEGGDTVDFVMKVEHLSFSETIERLAAQAGITLRYEEGGYTPGRQQGERTRLLEAHKVAAQYYAEQLGSAEAEIGRGFLADRGFDQAAAERFGVGYAPAGWDHLTRFLRGRGFTDKELTLSGLSQDGRRGPIDRFRGRLMWPIRDITGEVVGFGARRLREDDNGPKYLNTPETPIFRKSQVLYGIDLAKRDIGKQGRAVVVEGYTDVMACHLSGVTTAIATCGTAFGGEHVKILRRVLTDNSRSEVVFTFDGDAAGQKAALRAFEDDQKFAARTSIAVSPGGMDPCDLRLAKGDEAVRQLIEERSPLFGFAIRSFVTQHNLDTAEGRSAALEQAAPVVARIKDVAIRHEYAVQLAGMLGILDERFVVDRVRRLARYAAQGGGGRGRGGQGQAQGQGRGPGQGPGAGAPPAGPGAAAPAAGASGGPALYMRTPALHRERELLKLALQHPKLVAPAFDAYLADEFTAAPYATVRAAIEAAGGVAAADDSAAYLARVRDAAPDDGVRSLITELAVEPPRSRRDPDAIYAGEQLAGVRLAAVDRRIDDVRSTVHRLGAQGPPDQFESAQRELWTLQQYRESLRARGAAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDT4</accession>
    <name>A0A0F7NDT4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Bleomycin resistance protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_28705</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bleomycin resistance protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_28705"/>
    <dbReference type="EnsemblBacteria" id="AKH85563">
        <property type="protein sequence ID" value="AKH85563"/>
        <property type="gene ID" value="AA958_28705"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_28705"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6050"/>
    <dbReference type="OrthoDB" id="1900922at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08349">
        <property type="entry name" value="BLMA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000335">
        <property type="entry name" value="Bleomycin-R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19581">
        <property type="entry name" value="Glyoxalase_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="3">
        <location>
            <begin position="6"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH85563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="123" mass="13852" checksum="AC5447335563882D" modified="2015-07-22" version="1">MTVLFRRTAPILRIFDIAKAREFYLGYLGFTVDWEHRFADGFPLYMQVSRGDLTLHLSEHHGDASPGATVYVEVDGAGELHAELKAKDYPYLKPGLEEDAGIGTILELTDPFGNRLRFVQPNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NE09</accession>
    <name>A0A0F7NE09_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Rieske (2Fe-2S) protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_29160</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018867.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_29160"/>
    <dbReference type="EnsemblBacteria" id="AKH85638">
        <property type="protein sequence ID" value="AKH85638"/>
        <property type="gene ID" value="AA958_29160"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_29160"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6148"/>
    <dbReference type="OrthoDB" id="691776at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044043">
        <property type="entry name" value="VanA_C_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19112">
        <property type="entry name" value="VanA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="5">
        <location>
            <begin position="9"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH85638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="352" mass="38984" checksum="1F351838E46A285E" modified="2015-07-22" version="1">MPPFARNQWYVTAYGHEVGRELIARTVLGEPIALYRTEDEAAEVVALADRCVHRRFPLSQGRLDGDTVVCGYHGFTYDSTGACVFVPGQKRVPRTARVRSYPVVEQDSFVWVWIGDPAVADPRTIPRAAHLADPGWISVSGMETIRCDYGLLVDNLLDLSHETYLHGGYIGTPEVAETPIATEVDEGAGIVRVSRHMDDAACPPFYARSTGLEGRITRWQDIEYHAPCLYLLHSRIAPVGVLPEADGSDPHAFHTEITYAITPSAPGAVYDFWAVSRDFARDDPEVTAFLRDSNHTVVMQDVDALHVLQEALDREQDGYQELSINIDTGGLAARRILARLAEEGEKPVERVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NE18</accession>
    <name>A0A0F7NE18_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_24965</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018168.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_24965"/>
    <dbReference type="EnsemblBacteria" id="AKH84917">
        <property type="protein sequence ID" value="AKH84917"/>
        <property type="gene ID" value="AA958_24965"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_24965"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5261"/>
    <dbReference type="OrthoDB" id="1833499at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="2"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="311"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="320"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH84917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="391" mass="41269" checksum="765EF8953D6733A6" modified="2015-07-22" version="1">MIEAQGLTKTYGGKTAVYNLSFTVKPGVITGFVGPNGAGKSTTMRMILGLDEPSSGSVTVGGYPYRKLPNAPRQVGALLDAKAVHGGRSARNHLRCVAQLSGIPQRRVDEVLDVVGLREVAGRRSKGFSLGMGQRLGIAGALLGDPQILLFDEPVNGLDPEGILWIRNLMKRLASEGRTIFVSSHLMSEMALTADHLIVIGRGQLMADMSVRDFISTHSASFARVRVPDREQGLREKLTALLTEEGAQVQQEQDGALRVGGMPLPRISDLAHDARIQLWELSPHEASLEEAYMRMTQGAVDFRSTVDHRAGLQQPAGPVPAQGYTPPGPGYAPPMGAPGMPQGGPGMPPPGVQPGYAPPPPQGYAPPPPPAAPQGPAGAAAPAPREGETPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NEK8</accession>
    <name>A0A0F7NEK8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Zinc metalloprotease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AA958_26250</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNQ-509</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M50B family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018388.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_26250"/>
    <dbReference type="EnsemblBacteria" id="AKH85147">
        <property type="protein sequence ID" value="AKH85147"/>
        <property type="gene ID" value="AA958_26250"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_26250"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5525"/>
    <dbReference type="OrthoDB" id="1395197at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004387">
        <property type="entry name" value="Pept_M50_Zn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008915">
        <property type="entry name" value="Peptidase_M50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42837">
        <property type="entry name" value="PTHR42837"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02163">
        <property type="entry name" value="Peptidase_M50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="11" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="348"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="410"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="10">
        <location>
            <begin position="149"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AKH85147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="438" mass="47525" checksum="A4B1CCBCCB9799E3" modified="2015-07-22" version="1">MTTLMTILGIVVFALGLLVSIAWHEFGHLSTAKMFGIRVPQYMVGFGPTMFSRKKGETEYGIKWIPLGGYIRMIGMFPPGEDGRVQQRSTSPFRGMIEDARQAAYEELEPGDEKRLFYTRAPWKRVVVMFAGPFMNLVLAVVVFVGVMMTFGIATQTTTVGSVSDCVIKAESVAENPDRKCSDADPAAPAKKAGLERGDRIVAFNGRPVGDWETLQKSIRETIGPATVTVERDGKRVDLHPTLTENTVSKSDGDGGYVDGEYVKAGFLGFTPATGVVKQDFGQSVDRMGDMVVNGFDALIALPSKVPDLWDAAFQGEERKEDSPVGVVGAARVGGEVLNLDIPPEQRVASMLLLVAGFNLSLFLFNMLPLLPLDGGHIAGALWESVRRAFARVFRRPDPGPFDVAKLMPVAYVVAGVFICFTLLVLVADVVNPVKLTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NEX2</accession>
    <name>A0A0F7NEX2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PG_binding_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_30915</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019121.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH85893">
        <property type="protein sequence ID" value="AKH85893"/>
        <property type="gene ID" value="AA958_30915"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_30915"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6533"/>
    <dbReference type="OrthoDB" id="2042114at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.101.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036366">
        <property type="entry name" value="PGBDSf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="SSF47090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="PG_binding_1" evidence="3">
        <location>
            <begin position="214"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH85893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="280" mass="27655" checksum="A4365205950C9692" modified="2015-07-22" version="1">MRATEAGGGQDADGGSEPGPGTELLPVPRAAFLPQVAPGSAVARIEAAQPEPDDTVVGGGHRRRPTGLLLAAGGAAAVIAGLVVTAGLLTGGPESDEAGPGPARISTGPSGGGEADGGPLGDDEGAPADGTGAHPDDRAGRDRGDGNAPPAGRRAAGDDHAGDLAPGRTNGQIGSIAPTAPPAYGASHPPPSSSPTDGAPAVPVLPPVLGPGDSGPEVTELQHRLRQVGLGLLQPADGAYDDGVRTSVRTFQSVNNLEEDERGVYGPETRRELESRTDEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NEZ5</accession>
    <name>A0A0F7NEZ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">3-hydroxybutyryl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_24930</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_24930"/>
    <dbReference type="EnsemblBacteria" id="AKH87025">
        <property type="protein sequence ID" value="AKH87025"/>
        <property type="gene ID" value="AA958_24930"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_24930"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5255"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022694">
        <property type="entry name" value="3-OHacyl-CoA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006180">
        <property type="entry name" value="3-OHacyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000105">
        <property type="entry name" value="HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00067">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3HCDH_N" evidence="5">
        <location>
            <begin position="1"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="3HCDH" evidence="4">
        <location>
            <begin position="174"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="2">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH87025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="270" mass="28754" checksum="DE9C031B788E6C5C" modified="2015-07-22" version="1">MGSGIAQVAAQAGWHVVLRDLTDEALARGTDGIKGSYEKFVAKGKLDAATAEEALARITTTTDLDAAADADIVVEAVFERLDVKQDIFRTLDGLVRDDAVLASNTSAIPLTKIAAVTARPERVVGTHFFSPVPMMGLCELVRGLKTSDDTLARARAFAESTGKTCIVANRDVAGFVTTRLITALVVEAVKLYESGVATAEDIDVACRLGFGHAMGPLATADLTGVDILLHAAENIYTETQDEKFAPPELMRRMVDAGDIGRKSGRGFYEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NF92</accession>
    <name>A0A0F7NF92_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glutathione hydrolase proenzyme</fullName>
            <ecNumber evidence="4">2.3.2.2</ecNumber>
            <ecNumber evidence="4">3.4.19.13</ecNumber>
        </recommendedName>
        <component>
            <recommendedName>
                <fullName evidence="4">Glutathione hydrolase large chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="4">Glutathione hydrolase small chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_32365</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2 4">
            <text>an S-substituted glutathione + H2O = an S-substituted L-cysteinylglycine + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:59468"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="ChEBI" id="CHEBI:143103"/>
            <dbReference type="EC" id="3.4.19.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>an alpha-amino acid + an N-terminal (5-L-glutamyl)-[peptide] = 5-L-glutamyl amino acid + N-terminal L-alpha-aminoacyl-[peptide]</text>
            <dbReference type="Rhea" id="RHEA:23904"/>
            <dbReference type="Rhea" id="RHEA-COMP:9780"/>
            <dbReference type="Rhea" id="RHEA-COMP:9795"/>
            <dbReference type="ChEBI" id="CHEBI:77644"/>
            <dbReference type="ChEBI" id="CHEBI:78597"/>
            <dbReference type="ChEBI" id="CHEBI:78599"/>
            <dbReference type="ChEBI" id="CHEBI:78608"/>
            <dbReference type="EC" id="2.3.2.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>glutathione + H2O = L-cysteinylglycine + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:28807"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:61694"/>
            <dbReference type="EC" id="3.4.19.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Sulfur metabolism; glutathione metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">This enzyme consists of two polypeptide chains, which are synthesized in precursor form from a single polypeptide.</text>
    </comment>
    <comment type="PTM">
        <text evidence="4">Cleaved by autocatalysis into a large and a small subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the gamma-glutamyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.2" evidence="4"/>
    <dbReference type="EC" id="3.4.19.13" evidence="4"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019366.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_32365"/>
    <dbReference type="EnsemblBacteria" id="AKH86139">
        <property type="protein sequence ID" value="AKH86139"/>
        <property type="gene ID" value="AA958_32365"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_32365"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6832"/>
    <dbReference type="OrthoDB" id="595845at2"/>
    <dbReference type="UniPathway" id="UPA00204"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036374">
        <property type="term" value="F:glutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102953">
        <property type="term" value="F:hypoglycin A gamma-glutamyl transpeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103068">
        <property type="term" value="F:leukotriene C4 gamma-glutamyl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006750">
        <property type="term" value="P:glutathione biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043138">
        <property type="entry name" value="GGT_lsub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000101">
        <property type="entry name" value="GGT_peptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043137">
        <property type="entry name" value="GGT_ssub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00066">
        <property type="entry name" value="g_glut_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519404" description="Glutathione hydrolase proenzyme" evidence="6">
        <location>
            <begin position="23"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="382"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="457"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU368036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH86139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="602" mass="61825" checksum="3686620BC9317627" modified="2015-07-22" version="1">MRLRRPTVPLALAAILATAAAAAPPTAAGTDAAAPPKSAVATGYGGAVASVDADATAAGIEVLRDGGNAVDAAVATAAALGVTEPYSGGIGGGGYFVHYDARSGRVATLDGREKAPLTADAELFTENGAAIPFDQAVTSGLSVGVPGTPATWEQALRQWGTTSLGEALAPATRLAAEGFTVDETFRAQTAANEARFRDFPATRELFLPGGALPTVGSTLRNPDLAATYGQLADEGARAMYRGDLGADVSDTVRRPPVDPGADRVVRAGDLRPADLRAYRVAQQQPTHVGYRGLDVYGMAPSSSGGTTVGEALNILEGTDLGELSEAQYLHRFLEASRVSFADRGRWVGDPRFSRVPTRELLSQSYADSRACLISPDAVLTSPLAAGDPRRPDASCTAKGAPEGTSYEGPSTTHLTTADKWGNVVAYTMTIEQTGGSGITVPGRGFLLNNELTDFSFTPSVPGVPDPNLPGPGKRPRSSMAPTIVLDDGEPLLATGSPGGSTIITTVLQVLTGRLDRGLTLPEAIAAPRASQRNTASTSAEPGFLGLPARGELAELGHRFTDGGEIGAATGVERLPDGRWVAAAEPERRGGGAAAVVRPAGRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NG83</accession>
    <name>A0A0F7NG83_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_33525</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019555.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_33525"/>
    <dbReference type="EnsemblBacteria" id="AKH86333">
        <property type="protein sequence ID" value="AKH86333"/>
        <property type="gene ID" value="AA958_33525"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_33525"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.7080"/>
    <dbReference type="OrthoDB" id="1688736at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="226"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="269"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="84"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH86333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="303" mass="33202" checksum="8F82D304DFBCF352" modified="2015-07-22" version="1">MAVVAEPTRNRRRRRSGPHARREARIGLLFVLPCFLLFLAFRFGPAVAGVLMSFTDYTLTGGGSFIGADNFTRLKDDPLFWDALKVTVIYTVLAVPGTIAVSVGLALLTRRAFRGSKVFRSVFFLPVVTSLVLAATVFVWIFSTGGPWSTAMGWTGLPEESWLSHDTLVVPALALVGIWSRFGYGMLILLARMQDIPRELEEAALTDGAGPWQRFRHIVLPQLRPALFFLAVIETTASFQVFDAVYTMTGGGPANSSYTLVFQLYDAGFTYFDLGYAAAIGVALFGLTLVVALIQRLTIGKDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NG96</accession>
    <name>A0A0F7NG96_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_30090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018995.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH85767">
        <property type="protein sequence ID" value="AKH85767"/>
        <property type="gene ID" value="AA958_30090"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_30090"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6353"/>
    <dbReference type="OrthoDB" id="2193395at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH85767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="102" mass="11967" checksum="4151EF256DBF10A6" modified="2015-07-22" version="1">MTDNPWAWRDGHNPYRTTPFQVLALSPEVSGRAEIRNHVRKRRQRIERRADRYPLFGRTLRVAEVNAAEDRIKDPAARLLAELCTHRPERPAERERADDAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NGA6</accession>
    <name>A0A0F7NGA6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_30200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019010.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_30200"/>
    <dbReference type="EnsemblBacteria" id="AKH85782">
        <property type="protein sequence ID" value="AKH85782"/>
        <property type="gene ID" value="AA958_30200"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_30200"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6377"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004658">
        <property type="term" value="F:propionyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032716">
        <property type="entry name" value="ACC_epsilon"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13822">
        <property type="entry name" value="ACC_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH85782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="64" mass="6990" checksum="C052B7B5E3C22ADD" modified="2015-07-22" version="1">MRDRDAVKVERGSADAAELAALTVALLSRLRTGAGISGEYVPHSAAGRRRWERAAAYRAPHSWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NH90</accession>
    <name>A0A0F7NH90_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Nucleotidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_32025</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019310.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_32025"/>
    <dbReference type="EnsemblBacteria" id="AKH86082">
        <property type="protein sequence ID" value="AKH86082"/>
        <property type="gene ID" value="AA958_32025"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_32025"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6762"/>
    <dbReference type="OrthoDB" id="1822108at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH86082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="153" mass="17021" checksum="24A100109840046D" modified="2015-07-22" version="1">MFDLDGTLTDTRHRLHHLASSPKDWDGFFRAAPLDPPLPEGVALALRWAGTCEVSYVTGRPERTRGDTVAWLAAHGLPEGPLWMRRAGDRRPARVAKPELLRRVARGRTVAVVVDDDELVCQAYEKAGFPVVRADWMPSAEPLRAAQEDEGRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NHJ3</accession>
    <name>A0A0F7NHJ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_19335</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020238.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_19335"/>
    <dbReference type="EnsemblBacteria" id="AKH86899">
        <property type="protein sequence ID" value="AKH86899"/>
        <property type="gene ID" value="AA958_19335"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_19335"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4065"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="SSF56752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH86899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="260" mass="27786" checksum="DD50CE51DFD5BA83" modified="2015-07-22" version="1">MVTLNGKPVSVEALLPLALTNLGHFTSMRVDESGGIRGLALHLERLVRDCKVIWGADLDTECVRDYVRRAVGGQSRPCVVRVTVYDPKTDMGRPADADEPKILVSVRRAGAMPPAPLRAMSVPYERDLPEVKHVGLLGALRARRTAQLAGYGDALFVGRDGLVSEGGTWNVGFVDQNGTIVWPQAPVLPGVTMALLQQIAEHRIATVTLEQAKGMAAAFATNTSIGVRPLAAIDKAGFPTDHPVLGQLQAAYLLVPGETL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NHP9</accession>
    <name>A0A0F7NHP9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">F5/8 type C domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_33180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019497.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_33180"/>
    <dbReference type="EnsemblBacteria" id="AKH86272">
        <property type="protein sequence ID" value="AKH86272"/>
        <property type="gene ID" value="AA958_33180"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_33180"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.7009"/>
    <dbReference type="OrthoDB" id="167885at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519510" evidence="1">
        <location>
            <begin position="36"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="2">
        <location>
            <begin position="552"/>
            <end position="687"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH86272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="687" mass="74772" checksum="31816BAA014290AE" modified="2015-07-22" version="1">MTRQPYLRKAGLITLVTVLFAALTALGTGPGTAAAANDWWDPVARPAPDSGVNVTGEPFRGTDARGDVRGFVDAHNHVMSNEGFGGRIICGRPFDQRGVTEALKDCPEHYPDGALALFENVTGGADGHHDPVGWPTFEHWPAHDSLSHQQNYYAWLERAWRGGQRVMVQDLVTNGLLCSVYPAKDRGCDEMDSIRLQAEKTYEMQDYVDAMYGGAGRGWFRIVTDAEQARAVVEQGKLAVVLGVETSEPFGCKQVLGVAQCDKGDIDRGLDELYGMGVRSMFLCHKFDNALCGVRFDSGTIGAAVNIGQFLSTGTFWTTEKCTGRQQDNPIGLADPPAEAAKLLPAGVSVPSYDQEARCNTRGLSELGEYAVRGMMERNMMLELDHMSVKAAGRALDILESESYPGVLSSHSWMDLDWTERLYRLGGFSAQYMNAAEDFVEQGRRGAELRDKYGAGYGYGTDMNGVGGWPAPRGADAPDKVAYPFRSADGGSVLDRQVTGERTWDFNTDGGAHAGLVPDWIEQMRLHGGGDVVEDLMAGAESYLTTWGATQSHERPANLAAGAAATASSTEFSLLTSYAPGRAVDGDRGTRWASHWNDDQWLRLDLGEGRRIGRVTLDWERAYARAYRVEVSADGNAWRTVWATESGDGGLDTAVFDPTDARYVRVVGVQRGTGHGYSLYEVGVHAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NHV0</accession>
    <name>A0A0F7NHV0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">TVP38/TMEM64 family membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_17510</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the TVP38/TMEM64 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_17510"/>
    <dbReference type="EnsemblBacteria" id="AKH86848">
        <property type="protein sequence ID" value="AKH86848"/>
        <property type="gene ID" value="AA958_17510"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_17510"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3685"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="SNARE_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015414">
        <property type="entry name" value="TMEM64"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12677">
        <property type="entry name" value="PTHR12677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="SNARE_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="84"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="198"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU366058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH86848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="234" mass="23674" checksum="6E3F48C54F0DE256" modified="2015-07-22" version="1">MPESSATPGRGSSRGALVKLLVLVTLLAGTACWVVLGGAGLLGDIRRWVDGLGVWGPLVFVLCYALAVTALLPGSVLTASAGALFGLTVGVVVVMAGAIAGAVLSFGLARWLGRPAVARYTGAGRLARLDVHLSRRGFVAVLLLRLVALFPFAAVNYGAGVAGVRFGPYVAATALGILPATFVYTGLGGALGDPGSPLLWLAPAGLLVLSAGGWWATKLLRARTGDVSEAADSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NI01</accession>
    <name>A0A0F7NI01_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_33745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019594.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_33745"/>
    <dbReference type="EnsemblBacteria" id="AKH86372">
        <property type="protein sequence ID" value="AKH86372"/>
        <property type="gene ID" value="AA958_33745"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_33745"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.7125"/>
    <dbReference type="OrthoDB" id="1134430at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005129">
        <property type="entry name" value="GTPase_ArgK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23408">
        <property type="entry name" value="PTHR23408"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00750">
        <property type="entry name" value="lao"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="325" mass="34629" checksum="E683EF5FBD9461FF" modified="2015-07-22" version="1">MAIDLDTYVKGVLDGRRALVARAITLVESTRPQHRALAQELLTELLPHSGKARRIGVSGVPGVGKSTFVDAFGSMLTGLGHRVAVLAVDPSSSRTGGSILGDKTRMERLAVDPAAFVRPSPTAGTLGGVAKATRESIVVMEAAGYDVVLVETVGVGQSETSVANMVDSFLLLTLARTGDQLQGIKKGVLELADVIAVNKADGPHERDAKAAARELAGALRLMHGKGAFWTPPVLHCSAREATGLDTVWDRLERHRELLESTGRLAGRRRDQQVDWTWTMVRDELLGRLRADPAVGALAPGLEQQVRDGELTATRAAERILEAFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NI39</accession>
    <name>A0A0F7NI39_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Polyketide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AA958_20925</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_20925"/>
    <dbReference type="EnsemblBacteria" id="AKH86933">
        <property type="protein sequence ID" value="AKH86933"/>
        <property type="gene ID" value="AA958_20925"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_20925"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4409"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901362">
        <property type="term" value="P:organic cyclic compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="5" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="1 7" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="2014"/>
            <end position="2091"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="370"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="844"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="7">
        <location>
            <position position="2051"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AKH86933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="2096" mass="220235" checksum="D434DC440DB3F05D" modified="2015-07-22" version="1">MSAGADSQVRPWGGFLRNVSGFDADFFGVSGREAEVLDPQHRLLLEVAWEAFEHAGFRPESLNGMPVGVFTGMSYHDYMDGLTGHPRELEGSVLTNGHCVAPGRISYLLGLRGPSLSLDTACSSSLVALHLAAQSLNAGECELALAGGVSLILQPRTTQSFARMGMLSAAGHCHAFDAAADGFVRGEGCGVVVLKRLADAVRAGDRVLAVLRGSAVNQDGASEGLAAPSSDAQRALYIRALSAAGVDPCDVGMVETHGTGTPVGDPAEFASLAAVYGERRTDGGRCALTSVKTNLGHLEPAAGVAGLIKVIGSLGRGLIPPNLHFTDWNPACRPEGTRLFVPTGLVEWPVRSGPRLASVSSFGFAGTNAHAVLEQPPTSRSRGGRGRPKPTVPPPSPEPEVFLVPAGSTAVLPDAALRLAEWLEGDGASVPLRDVAHTLAMRRSPGRGRLGVVADSHGLLAESLRTYAAGQAEPHVVTGSVGSGISRRPVWVFSGQGSQRPGMGSGLLDTVPAFASALAEVDELITAEAGFSVLDVVRRGRPVNGCGRVQPVLFALQIALAAAWRGHGVEPAGVIGHSMGEVAAAVVAGALSLADGVRVICRRSALLERVAGHGAMASVELDAETVAAEIAAVGADPDTPAGQVSVAVLSAPGVTVVAGDTARVHRMVEDWQARGVPASTVAVDVASHSPQVDPLLDDLRAALVDLTPRSPHLPFYSTVLDDPNGRPAFDSGYWCENLRRPVRFAAAVAAAAADRHTLYVEISPHPVVSRALTRSLAAQGAQVTEPVVLPTLLRDEDELATLRVQLAALHCAGTTVDWSVLYADAQLADVPTIAFDRTRHFTRPEIPRPRSEASPGGADADPLPGRRTEIPGTPHRLCWHGDTGISRLPWLADHQVYGSAALPGAVHCAIALSCACDAFNAGPHEVEVADVRFLELLRLTERTPVSTTVTLTDADHAQCEIYARGEKDTWVLQATAVLRRRAPVPRSSLSSVGSLASGHPRRLDPRILYESLRARGLTHGPAFTGVLGLRGAEDGESYWAQVEVPQEARRSGYGSLRIHPVLIDLCAQLVAARLIEEADSGTLLPVGMRDLRVLGDIASTVYCHAHIAETSDDGLTGNVRLLDQAGSPVLSIDGLKFTRRAATNSKAVDSWFSGIRWSESPRRTPSRDLSAPTMLIISESGQDAESSRALARAIESAGGKAAVWKPPPAQEGLQGLTASLVARLEASKEPPRVVAVLCRQDGDGEAGQDPAAVGLRQVRLLLAAAQAITGVAAGPVRLYAVTRGSRPVRPGDTADPAQGALRGVVRVLALEHPELQATLVDADARSGTDTGKGGDRAALRELACELMSYQVPDTENLEDEVALRGGARHVARLERTPLTKGERVLAARMVRSGEDGFRLLVRRPGDLTSLRLAESPRIAPGAGEVEVRVTATGLNFRDVLIALGVLPGAGAGDGATGAFDGIGFECAGVVTAVGPGVERCCVGDDVLAVSLEGGAFASFVTLPARAVASIPPGLGAVAAAGLPIPFLTAWYALRHVARLAPGERVLIHSATGGTGLAAIAVARHLGAEVLATAGSEEKRSHLRAMGIAQVMDSRTLDFRDRTREATGGEGVDVVLNSLSGAAIRAGLETLRPFGRFIELGVRDILSDGLLGLSPLRHNITFRTVDLIELQRSQPEVFDEVLREVLGQFTAGELAPLHSTTFPLTAASQAFRLMAGARHLGKVVLTTPAQGETVAVLSAEPVTARRDGAYIITGGLRGVGLATAQWLAQQGAGHLVLNGRTRPTPQATATLRDLDAQGTKITVVLGDIAEQQTAERLVAAAGKQPWPLRGVVHGAMVLADAAVTTLDEERLRKAWKPKADGAWHLHRATASHRLDWFVVHSSMASLLGNPGQAGYAAANAWLDAFAAWRTALGLPTLAVNWGPWGEIGVATDFSERGYQTIPTEMGFRALQELLVHESVQAGVIPGDAGTWIPRVGWGRDFFSLVRPDGDAGASGSEESPGELVERLRSMPAGTDQRRALETFLADHIRAVLRIGATRIDPQTPLRSLGFDSLLATEVRARIEPVLGVRLAGDFVWRHRTLAALAEGLSERLGLTPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-12-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NIA4</accession>
    <name>A0A0F7NIA4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_23665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86993">
        <property type="protein sequence ID" value="AKH86993"/>
        <property type="gene ID" value="AA958_23665"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_23665"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4988"/>
    <dbReference type="OrthoDB" id="1775418at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028978">
        <property type="entry name" value="Chorismate_lyase_/UTRA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011663">
        <property type="entry name" value="UTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07702">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00866">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64288">
        <property type="entry name" value="SSF64288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="234" mass="26246" checksum="8B1BE32A1A1783CD" modified="2015-07-22" version="1">MPKYYRLKRHLLEMTETLPPGTPVPPERTLASEFDTSRTTVRQALQELVVEGRLERIQGKGTFVAKPKVSQALQLTSYTEDMRAQGLEPTSQLLDIGYVTAGDQLAERLDITPGGRVLRIERLRLANGEPMAIETTHLSAKRFPALRRSLVKHSSLYTALAEVYDVHLAEAEETIETSLATPREAGLLGTDTGLPMLMLSRHSVDTHGEPVEWVRSVYRGDRYKFVARLRRPVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NIB4</accession>
    <name>A0A0F7NIB4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Stilbene synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_31865</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thiolase-like superfamily. Chalcone/stilbene synthases family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020618.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_31865"/>
    <dbReference type="EnsemblBacteria" id="AKH87184">
        <property type="protein sequence ID" value="AKH87184"/>
        <property type="gene ID" value="AA958_31865"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_31865"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6729"/>
    <dbReference type="OrthoDB" id="872193at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012328">
        <property type="entry name" value="Chalcone/stilbene_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001099">
        <property type="entry name" value="Chalcone/stilbene_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011141">
        <property type="entry name" value="Polyketide_synthase_type-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11877">
        <property type="entry name" value="PTHR11877"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02797">
        <property type="entry name" value="Chal_sti_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00195">
        <property type="entry name" value="Chal_sti_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000451">
        <property type="entry name" value="PKS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chal_sti_synt_N" evidence="4">
        <location>
            <begin position="94"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Chal_sti_synt_C" evidence="5">
        <location>
            <begin position="262"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000451-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH87184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="376" mass="40461" checksum="AE5C3EF4C12C4569" modified="2015-07-22" version="1">MITGLESEELLDPRSATAQVPGPYRPRILGVGTAATPTTYTQQEVLDAFGITDPRISSVFLNSAIERRHLTLPAPDEHGVRHSEPQGDLLDKHKATAIEMGAQALRACLKSAGHELSDLRHLCCVTSTGFLTPGLSALLIRELGIDRHCSRSDIVGMGCNAGLNALNVVSGWSAAHPGELAVVLCAEACSAAYAFDETMRTAVVNSLFGDGAAAVALMSGAAFVSPDGARGPDVLKFASCLIPEALEAMRYDWDRDQDRFSFFLDPLIPYVVGAHAELVVDRLLEDTGLRRSDIRHWLVHSGGKKVIDAVVVNLGLTRHDVRHTVGVLRDYGNVSSGSFLFSYERLLDEDVTHPGDHGVLMTMGPGSTIETALVRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NIE7</accession>
    <name>A0A0F7NIE7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Bifunctional uridylyltransferase/uridylyl-removing enzyme</fullName>
            <shortName evidence="7">UTase/UR</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Bifunctional [protein-PII] modification enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Bifunctional nitrogen sensor protein</fullName>
        </alternativeName>
        <domain>
            <recommendedName>
                <fullName evidence="7">[Protein-PII] uridylyltransferase</fullName>
                <shortName evidence="7">PII uridylyltransferase</shortName>
                <shortName evidence="7">UTase</shortName>
                <ecNumber evidence="7">2.7.7.59</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="7">[Protein-PII]-UMP uridylyl-removing enzyme</fullName>
                <shortName evidence="7">UR</shortName>
                <ecNumber evidence="7">3.1.4.-</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="7" type="primary">glnD</name>
        <name evidence="11" type="ORF">AA958_25900</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen metabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[protein-PII]-L-tyrosine + UTP = [protein-PII]-uridylyl-L-tyrosine + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13673"/>
            <dbReference type="Rhea" id="RHEA-COMP:12147"/>
            <dbReference type="Rhea" id="RHEA-COMP:12148"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:90602"/>
            <dbReference type="EC" id="2.7.7.59"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[protein-PII]-uridylyl-L-tyrosine + H2O = [protein-PII]-L-tyrosine + H(+) + UMP</text>
            <dbReference type="Rhea" id="RHEA:48600"/>
            <dbReference type="Rhea" id="RHEA-COMP:12147"/>
            <dbReference type="Rhea" id="RHEA-COMP:12148"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:90602"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="7">Uridylyltransferase (UTase) activity is inhibited by glutamine, while glutamine activates uridylyl-removing (UR) activity.</text>
    </comment>
    <comment type="domain">
        <text evidence="7">Has four distinct domains: an N-terminal nucleotidyltransferase (NT) domain responsible for UTase activity, a central HD domain that encodes UR activity, and two C-terminal ACT domains that seem to have a role in glutamine sensing.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the GlnD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.59" evidence="7"/>
    <dbReference type="EC" id="3.1.4.-" evidence="7"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_25900"/>
    <dbReference type="EnsemblBacteria" id="AKH87038">
        <property type="protein sequence ID" value="AKH87038"/>
        <property type="gene ID" value="AA958_25900"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_25900"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5454"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008773">
        <property type="term" value="F:[protein-PII] uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006808">
        <property type="term" value="P:regulation of nitrogen utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00277">
        <property type="entry name" value="PII_uridylyl_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013546">
        <property type="entry name" value="PII_UdlTrfase/GS_AdlTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002934">
        <property type="entry name" value="Polymerase_NTP_transf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010043">
        <property type="entry name" value="UTase/UR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47320">
        <property type="entry name" value="PTHR47320"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08335">
        <property type="entry name" value="GlnD_UR_UTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01909">
        <property type="entry name" value="NTP_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006288">
        <property type="entry name" value="PII_uridyltransf"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01693">
        <property type="entry name" value="UTase_glnD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 7" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="2 7 11" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 7 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HD" evidence="10">
        <location>
            <begin position="520"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="9">
        <location>
            <begin position="880"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="region of interest" description="Uridylyltransferase" evidence="7">
        <location>
            <begin position="1"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="769"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="848"/>
            <end position="874"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AKH87038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="949" mass="98652" checksum="834C533237A56D9E" modified="2015-07-22" version="1">MAAAGPPGGTGGPSRGTQGAGRVASRTGPAPAAPGEGARPGGAPVSGDGAGSGPPAGEKDPRPARGAAHSVPGSAASGAPPAEESYAAARVRLLDAEGGAPRRAALARATDRWLAGLLHGAAGGAVSGSVSGAGPGDARGLRGVALVAVGGYGRGELSPRSDLDLLLLHDGSLRPAGLAALADRLWYPVWDMGLALDHSVRTSAEALKTAADDLKVTLGLLDARHVAGDAALTSALRTAVFADWRNRAARRLPELRELGRERAERHGELQFLLEPDLKEARGGLRDATALRAVAASWLADAPREGLDRARARLLDTRDVLHLTTGRATDRLALQEQDQVAEALGLLDADTLLREVYEAARTLAYATDVTWREVDRVLRARGGRRGAARLRNLIGSGQRGPAERTPLADGVVEQDGEVVLARTARPARDPVLPLRAAAAAAQAGLPLSLHAVRLLAAQAPPLPVPWPDEAREQLVTLLGAGEATVQVWESLEAEGFLTRLLPDWERVRCRPQRNAVHRWTVDRHLVETAVRAAALTRRVGRPDLLLVAALLHDIGKGWPDGPGGHSATGETIARDMARRIGFPPADVAVVATLVRHHLLLVETATRRDLDDPATVRLVADAVGGRGTLELLHALTEADALATGPAAWSAWRASLVADLAGRVGAALAGEPAGAAEERAERAPGAAEERLAVEAWRTRAPALTLRARTEEPPPAEAELEGAAGTERAGALPLGVELLVALPDRPDALAALAGVLALHRLTVRTAELRPLRLPPGVADGLEPAPDRTGTPAGAGPGPAAGPGTPDDPDTPHVLLLNWRVASEFGSLPAADRLRADLLRVLDGTLDVPARLAEREKAYRPRRRGTPGPPPRVTVAPGSSQHATVIEVRAQDAPGLLHRIGRALEAAGVRVRGAYVSTLGANAVDAFYVTDPAGRPLADRAADELAGSLQAALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NIM7</accession>
    <name>A0A0F7NIM7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">GTPase Era</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">era</name>
        <name evidence="12" type="ORF">AA958_09260</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 8 9">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019898.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_09260"/>
    <dbReference type="EnsemblBacteria" id="AKH86637">
        <property type="protein sequence ID" value="AKH86637"/>
        <property type="gene ID" value="AA958_09260"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_09260"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1954"/>
    <dbReference type="OrthoDB" id="984717at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04163">
        <property type="entry name" value="Era"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00367">
        <property type="entry name" value="GTPase_Era"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030388">
        <property type="entry name" value="G_ERA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005662">
        <property type="entry name" value="GTP-bd_Era"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004044">
        <property type="entry name" value="KH_dom_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42698">
        <property type="entry name" value="PTHR42698"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07650">
        <property type="entry name" value="KH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00436">
        <property type="entry name" value="era"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51713">
        <property type="entry name" value="G_ERA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50823">
        <property type="entry name" value="KH_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 6 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Era-type G" evidence="11">
        <location>
            <begin position="9"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="KH type-2" evidence="10">
        <location>
            <begin position="213"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="G1" evidence="8">
        <location>
            <begin position="17"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="G2" evidence="8">
        <location>
            <begin position="43"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="G3" evidence="8">
        <location>
            <begin position="64"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="G4" evidence="8">
        <location>
            <begin position="127"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="G5" evidence="8">
        <location>
            <begin position="161"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="17"/>
            <end position="24"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="64"/>
            <end position="68"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="127"/>
            <end position="130"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AKH86637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="309" mass="33742" checksum="D68EB051F3787EAE" modified="2015-07-22" version="1">MTTPDTGHRSGFACFVGRPNAGKSTLTNALVGQKVAITSSRPQTTRHTVRGIVHRPDAQLVLVDTPGYHKPRTLLGQRLNDAVRATWAEVDVIGFCAPANEKIGPGDRYIAGELAALRRTPKVAVVTKTDLADSDTVAAQLVAVDRMAKDLGFEWAEVVPVSAVEGKQVGLLADLLVPLLPEGPELYPDGELTDEPEQVMVAELIREAALEGVRDELPHSIAVVVDEMEPREDRPADRPLLDIHANLFIERDSQKGIVIGPKGKRLKEIGTKARGHIEALLGMPVYLDIHVKVAKDWQRDPKKLRRLGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MXJ6</accession>
    <name>A0A0F7MXJ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Toxin-antitoxin system, toxin component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_00920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH80965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014331.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_00920"/>
    <dbReference type="EnsemblBacteria" id="AKH80965">
        <property type="protein sequence ID" value="AKH80965"/>
        <property type="gene ID" value="AA958_00920"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_00920"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.204"/>
    <dbReference type="OrthoDB" id="1996962at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="18"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH80965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="87" mass="9253" checksum="529FFF304FB9140E" modified="2015-07-22" version="1">MTSMPRYVSCSTALDGLRWRRSSHSTGANNCVEAAYPVGPESAGLLAVRDSTRVEGPALLFRAEAWRAFVAAVKDGEFSGGARTAYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MYS8</accession>
    <name>A0A0F7MYS8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_00505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH80896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014262.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH80896">
        <property type="protein sequence ID" value="AKH80896"/>
        <property type="gene ID" value="AA958_00505"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_00505"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.117"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH80896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="91" mass="9511" checksum="333A9DABCF6336D4" modified="2015-07-22" version="1">MDRDEELLRGRVYGTEHDDPHPGPRPGRDYAELVGGPLDGLLLDITGWTAAETAAGAALPTELGRFGAGGRATYAPAPGSPGRWVWAGDIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MZX7</accession>
    <name>A0A0F7MZX7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Indole-3-glycerol phosphate synthase</fullName>
            <shortName evidence="8">IGPS</shortName>
            <ecNumber evidence="8">4.1.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">trpC</name>
        <name evidence="10" type="ORF">AA958_06160</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+) = (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:23476"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="EC" id="4.1.1.48"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the TrpC family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.48" evidence="8"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015213.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_06160"/>
    <dbReference type="EnsemblBacteria" id="AKH81860">
        <property type="protein sequence ID" value="AKH81860"/>
        <property type="gene ID" value="AA958_06160"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_06160"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1287"/>
    <dbReference type="OrthoDB" id="1789381at2"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00043"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004425">
        <property type="term" value="F:indole-3-glycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00331">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00134_A">
        <property type="entry name" value="IGPS_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00134_B">
        <property type="entry name" value="IGPS_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045186">
        <property type="entry name" value="Indole-3-glycerol_P_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013798">
        <property type="entry name" value="Indole-3-glycerol_P_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001468">
        <property type="entry name" value="Indole-3-GlycerolPSynthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22854">
        <property type="entry name" value="PTHR22854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00218">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00614">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="4 8" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="7 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="IGPS" evidence="9">
        <location>
            <begin position="4"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AKH81860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="269" mass="28252" checksum="FBF2FD017F840E04" modified="2015-07-22" version="1">MSVLDEIIDGVREDLAERQARVGLDELKERAARAPQARDGVAALRGDSVTVVCEVKRSSPSKGALAAIADPAALAADYEAGGAAVISVLTEQRRFGGSLADLEAVRAKVDLPVLRKDFVVTSYQLWEARAYGADLVLLIVAALEQEALVSLVERAESIGLTPLVEVHDEEETERAVAAGAKIIGVNARNLKTLEVDRGNFGRVAPEIPDHIVKIAESGVRGPHDLIAYANDGADAVLVGESLVTGKDPRAAVADLVAAGAHPALRHGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N075</accession>
    <name>A0A0F7N075_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_07020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015361.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_07020"/>
    <dbReference type="EnsemblBacteria" id="AKH82010">
        <property type="protein sequence ID" value="AKH82010"/>
        <property type="gene ID" value="AA958_07020"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_07020"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1470"/>
    <dbReference type="OrthoDB" id="710201at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="544" mass="57104" checksum="3CE7DE77866CBBFD" modified="2015-07-22" version="1">MTTERPSQRPPNRQLAALISEAGFSNAGLARRVDQLGLEHGLDLRYDKTSVTRWLRGQQPRGTTPALIAEVFTRRLGRRLTAQDLGLDACAPVYAGLEFAATPTEAIDIVSGLWRKDTGSQAELRKIAFTPAGLVVPSRDWLIGRPDEKVARELQQRGAPGAAVSTGPPGAVRVPAQGRGPGVGLGGGVGVGAGAGAGAGAGTGPGAPGGPGGVAGAGGAGGVAAGRGDPGPGWGGPGARAPGQRVTQGDIGAMRSVAEMFRALDNAYGGGHARQALVRYLEHEVEPMLRGTYNEATGRRLFSAAADLTRLAGWTSYDIGAHGLAQRYFVQALRLAQASGDRAYGSYVLVTMSRQAVYLGHGREAVQLTRVAQQGVGGGAPPVVQALLHAAEARGHGLLGEVRACTTSLARAERALESARPGEEAPHWARFFDEAQLADECGHCHRDLQQYRTAAQHAERSLQLRAAGFARSRVFCRLVLATARLGLGEVEQACVLGAEAAQQAAEMRSARAAEYVRDFERRLEPYRDAPPVRAYRERVAALAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0Y8</accession>
    <name>A0A0F7N0Y8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Putative 3-methyladenine DNA glycosylase</fullName>
            <ecNumber evidence="5">3.2.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_05025</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the DNA glycosylase MPG family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.-" evidence="5"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015016.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_05025"/>
    <dbReference type="EnsemblBacteria" id="AKH81661">
        <property type="protein sequence ID" value="AKH81661"/>
        <property type="gene ID" value="AA958_05025"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_05025"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1053"/>
    <dbReference type="OrthoDB" id="1385409at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003905">
        <property type="term" value="F:alkylbase DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00540">
        <property type="entry name" value="AAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00527">
        <property type="entry name" value="3MGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011034">
        <property type="entry name" value="Formyl_transferase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003180">
        <property type="entry name" value="MPG"/>
    </dbReference>
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        <property type="entry name" value="MPG_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10429">
        <property type="entry name" value="PTHR10429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02245">
        <property type="entry name" value="Pur_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50486">
        <property type="entry name" value="SSF50486"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00567">
        <property type="entry name" value="3mg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4 5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH81661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="212" mass="23188" checksum="863181BD79E925D4" modified="2015-07-22" version="1">MPRTPLDRSFFRRPVLEVAPDLLGRTLLRRTAAGTISLRLTEVEAYAGEQDPGSHAYRGRTDRNAVMFGPAGHIYVYFTYGMWHCMNVVCGEEGAASAVLLRAGEVTEGTELARKHRPKARKDRELAQGPARLATALDVDRSLNGTDACTPGTPLELLAGTPADHTRIRTGPRTGVGGDGAHHPWRYWIADDPTVSPYRAHEPRRRPKAAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N148</accession>
    <name>A0A0F7N148_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_05435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH81731">
        <property type="protein sequence ID" value="AKH81731"/>
        <property type="gene ID" value="AA958_05435"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_05435"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1140"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="70" mass="6985" checksum="CD4CC6C19DB91CBB" modified="2015-07-22" version="1">MAALGVGVGVRDLFERVGPLDARCVAAPPTEFGGFGEKTAAAATRIRTSPGPGCGSGTCSTTRVSTPPYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N161</accession>
    <name>A0A0F7N161_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_02005</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014507.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH81143">
        <property type="protein sequence ID" value="AKH81143"/>
        <property type="gene ID" value="AA958_02005"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_02005"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.433"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH81143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="302" mass="29674" checksum="B9280BC14621F65A" modified="2015-07-22" version="1">MSGSGGTSPYAWLPRGAREWSPPYGGLPGTWPRFTAAYALLVLLRITGDVPVPWLLGAAAVVGAASVAGYWLRRRGFRPRGGSWVLAGRGAASLVAPGGAAGAAVRTTVAGGGRVLGGAEAAAALRGAAALLRAADRDAALLTAVASGPGRDGGALYVVYDEASAFVLRAGAPGASRADRPGGKPDRGTGARQRALLADLAGELGAEVPPGDDPAGSGGVDGAGAPGDAPDELTPAGRAAASLAATAAAAAGTPLPATDPDVRPLPWPPHRAAAATADGALRLLTFAVPVALWLAWLAGAWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N1F6</accession>
    <name>A0A0F7N1F6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_09230</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015726.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_09230"/>
    <dbReference type="EnsemblBacteria" id="AKH82380">
        <property type="protein sequence ID" value="AKH82380"/>
        <property type="gene ID" value="AA958_09230"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_09230"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1947"/>
    <dbReference type="OrthoDB" id="1687028at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="114"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="3">
        <location>
            <begin position="302"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="408"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH82380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="459" mass="47879" checksum="0D7F4FB347912EFF" modified="2015-07-22" version="1">MVVMQSARARLSGLKQPTRRDVLFTALVGVVVACLALFGGAEESAHRPDAFGWLLLFVMVAVLAWRRHYPMAVFLVSVLPEAPYHILDNIHSAPTPTMLVAVYSLAVAGPRLRTLLITCGLVVLAVTMLTLRNADQGAELLRTSGWVMSVALLGEAVRVHRNYVGAIVERAERAERTREETAARRVAEERLRIAQDLHDLLAHSITLIGVQTSVAAHLLVADPGRLDRAALADALDGIAGTCRDSRAELRTTLQVLRGGDSVDGTRPPPGLAGLDDLAAAARSGGAEVRLDVADAAVDVPRGVGAAAYRIVQQSLTNAVQHAGSAVHVRISVTYDEEAGELRIAVVDDGPAHPEKAAAAAGAGARPGYGIVGMRERARSVGGTLEAARRTDAAGFAVTAVLPCVPAGPDGVETVEADPADPADNAGPASPAEPAAPGDHAAPADRPGARTAFTDRSRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N1W4</accession>
    <name>A0A0F7N1W4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_03555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014771.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_03555"/>
    <dbReference type="EnsemblBacteria" id="AKH81413">
        <property type="protein sequence ID" value="AKH81413"/>
        <property type="gene ID" value="AA958_03555"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_03555"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.749"/>
    <dbReference type="OrthoDB" id="741829at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="308" mass="29992" checksum="341925CF97B42C72" modified="2015-07-22" version="1">MTHARPGLGEPRGPAFTAGDRAGTAAPRPAGGPPQAGPVPPASPYRVPPAPTPTPPPAPRRAANRALAVAVVAAVLAGGAAGFAAGEIRGPGGGEEAAAGALPPAAAGRNPGDLDSVAARVLPSVVSVQAGERQGSGFVFDDRGRILTNAHVVGTATDATVVLHSGRRVDAEVLGRDTGRDVAVLEVAGPYAPRPLPRGRAADLSVADSVLAIGSPLGLTGTVTSGIVSAVDREVSLGGGAQQRAVQTDASINPGNSGGPLVDAAGRVVGINTAIASLDRGSGGSIGIGFAVPVEDAVRAADSIIDGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2J5</accession>
    <name>A0A0F7N2J5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ImpB/MucB/SamB family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_04725</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase type-Y family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014968.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_04725"/>
    <dbReference type="EnsemblBacteria" id="AKH81613">
        <property type="protein sequence ID" value="AKH81613"/>
        <property type="gene ID" value="AA958_04725"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_04725"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.996"/>
    <dbReference type="OrthoDB" id="442163at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11799">
        <property type="entry name" value="IMS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100879">
        <property type="entry name" value="SSF100879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UmuC" evidence="4">
        <location>
            <begin position="25"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="309"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH81613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="340" mass="36246" checksum="7AF91FA0F951B273" modified="2015-07-22" version="1">MTARRRHIAHLHLHASPSEEQYADIVELMGGVTPHVQEMPPNAVQLDLTSALRYFDLSAYDAVQLVKMRLKALYGIDSSAGLAGNRMLAAMAADASAPGETTTVPTGRAAEWLYPRPVAALPGVGRATAEKLGRYGLHTVGQIADLPAVTLQRLLGVNQARLLGDRARGYDPRPVTPAEPAASLSAELVLDADCLDPVRHHRAVLGLAERIGQRLRGEGQVAGRVTLVVRYADRSSTTRTRAIAEPTDHSPVLAATALGLLAALGLQRARVRAYALSADHLLPAAGAYRQLSLDPGDVRARRAEAAADRARRRFGPEAVRPATLAAEPPAAGWKERGRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2L5</accession>
    <name>A0A0F7N2L5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_04825</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014984.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_04825"/>
    <dbReference type="EnsemblBacteria" id="AKH81629">
        <property type="protein sequence ID" value="AKH81629"/>
        <property type="gene ID" value="AA958_04825"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_04825"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1016"/>
    <dbReference type="OrthoDB" id="626204at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="27"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="244"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="282"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="348"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="372"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="415"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="483"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="27"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="516"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="563"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="601"/>
            <end position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH81629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="626" mass="63582" checksum="22106E3DC71C74B9" modified="2015-07-22" version="1">MSGTATATSPPRDAPGAHGGGAGRWTVLAVLCSSLLLVALDATVLHVAVPALTEDLKPGAVDLLWIVDAYPLVAASLLILFGTLGDRVGRRRVLLLGYAIFGLASALAAAASDPHVLIAARALLGVGGAMIMPATLSILRQVFPDRRERAAAIGLWSATAAVGAAIGPLLGGFLLEHFWWGSVFLINIPLMVIAVPVGRWLLPESTADRAGPWDVLGALIAAVGLFGVVLALKQAGAGDGPLHPAVVAPLVFGGALLVLFVRRQRRRAHPLVDFDVISCRSFGTAVGCIVLALLALVGLQLVAVQYMQLVLGLSPLETGLRLIPLTVAAVAAGLAGSRMVARLGPRAMVALGFLVTAVAVTGLISLGEEDRPLVLCAGFVLLGYGLETTIFGAYESMLSETPAEQAGGVAAIGETSYQLGAGIGIALLGSVMNAVYRPALGTVPGVPSSATDAAGNSLGEAYETAAGLGGAAGATLRDAARDAFVQGMHVTLAVSAGLLLLGALTALRLPRSMECGEPGEAGGGPANDAREAAGEAAGAGSAAPAGVRRERGAAVGVRDGGGRVWERGARPARLRRVQEVTPRAGRVDDAEYAQVASGRDPEGPPEDDSHGLKHYAAVQPRRSAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2N0</accession>
    <name>A0A0F7N2N0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Galactose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="13">2.7.7.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">AA958_12075</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12 13">
            <text>alpha-D-galactose 1-phosphate + UDP-alpha-D-glucose = alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:13989"/>
            <dbReference type="ChEBI" id="CHEBI:58336"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="2.7.7.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.12" evidence="13"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016185.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_12075"/>
    <dbReference type="EnsemblBacteria" id="AKH82850">
        <property type="protein sequence ID" value="AKH82850"/>
        <property type="gene ID" value="AA958_12075"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_12075"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2540"/>
    <dbReference type="OrthoDB" id="1064872at2"/>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008108">
        <property type="term" value="F:UDP-glucose:hexose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033499">
        <property type="term" value="P:galactose catabolic process via UDP-galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001937">
        <property type="entry name" value="GalP_UDPtransf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019779">
        <property type="entry name" value="GalP_UDPtransf1_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005850">
        <property type="entry name" value="GalP_Utransf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005849">
        <property type="entry name" value="GalP_Utransf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11943">
        <property type="entry name" value="PTHR11943"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02744">
        <property type="entry name" value="GalP_UDP_tr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01087">
        <property type="entry name" value="GalP_UDP_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000808">
        <property type="entry name" value="GalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="SSF54197"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00209">
        <property type="entry name" value="galT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00117">
        <property type="entry name" value="GAL_P_UDP_TRANSF_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8 13" id="KW-0299">Galactose metabolism</keyword>
    <keyword evidence="6 11 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 13 16" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 11" id="KW-0862">Zinc</keyword>
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            <end position="194"/>
        </location>
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            <end position="358"/>
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        </location>
    </feature>
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        <location>
            <position position="70"/>
        </location>
        <ligand>
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        </ligand>
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        <location>
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        </location>
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        </ligand>
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        </location>
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        </ligand>
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        </location>
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        </ligand>
    </feature>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
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    </evidence>
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        </source>
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        </source>
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        <source>
            <dbReference type="RuleBase" id="RU000506"/>
        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AKH82850.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="362" mass="40057" checksum="3421A31BC18DCFDD" modified="2015-07-22" version="1">MKKTHTRLADGRELIYFDARDDAVRDAADRRPLEPTRTASEARFDPLRGEWVVIASHRQGRTYRPPADECPLCPSRSGRLSEIPADDYEVAVFENRFPSLTGGPGPETGEPPFVSAPGAGRCEVVCFTSDHDASFAGLSPGQAALVLDAWTDRSVELGELPGVEQVFCFENRGEEIGVTLGHPHGQIYAYPYVTPRTAQMMHCADLHRARTGENLFDTVVAAETAAGVRVVLEGAHWVAFVPYAAHWPYEVHLYPRRRVPDLPALGDAARAEFPEVYLELLRRFDRIFGPGEPPTPYISAWHQAPVRAPGRDDYALHLELFTIRRSPGKLKYLAGSESAMDAFVTDVPPEQAAERLREVASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2T8</accession>
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                <person name="Albersmeier A."/>
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                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <feature type="domain" description="HisKA_3" evidence="2">
        <location>
            <begin position="186"/>
            <end position="256"/>
        </location>
    </feature>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH82331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
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</entry>
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        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_02670"/>
    <dbReference type="EnsemblBacteria" id="AKH81257">
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        <property type="gene ID" value="AA958_02670"/>
    </dbReference>
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    <dbReference type="PATRIC" id="fig|444103.5.peg.570"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="23"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="66"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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            <end position="170"/>
        </location>
    </feature>
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            <end position="198"/>
        </location>
    </feature>
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            <end position="230"/>
        </location>
    </feature>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
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            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="5">
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            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="451"/>
            <end position="471"/>
        </location>
    </feature>
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        <location>
            <begin position="24"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH81257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="514" mass="52141" checksum="9E67BD3204596805" modified="2015-07-22" version="1">MTHSHPPAGAPADLRLAQPAGRWLLTAVVIGSGITFLDATVVNVALPTIGDELGASLGGLQWTVNGYTLTLAALILLGGALGDRYGRRRIFIFGTVWFAVASLLCALAPNVGILIAARTLQGIGGALLTPGSLALIQASFAPEDRARAIGVWSGLAGIASALGPLLGGWLVEAASWRWVFAINVPLAAVVVAVAARHVPESRDETATGRFDWTGAALGALGLAGVTYALIAAPEKGVSALLLAASSAVGVASLAAFVCVQRRSSHPMLPTGTFGSRQFTAANLVTFVVYAALGGVTFFLVLDLQIAAGYSPIAAGSALLPVTLIMLALSERSGKLSERIGPRIPMTVGPAICAGGLLLMLRIGGPGDNVSYVREVLPGVVLFGFGLATTVAPLTATVLGAVEDRHSGIASGANNAVARAAGLLAVAALPLAAGLSGNDYRNPGAFGDGFRVALLICAALLAGGAVLSWLTIRSPKKPAVPAEPPCHVHCAVAGPPLQSLIEDPPATDPEEPERP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N352</accession>
    <name>A0A0F7N352_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_05760</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015141.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_05760"/>
    <dbReference type="EnsemblBacteria" id="AKH81788">
        <property type="protein sequence ID" value="AKH81788"/>
        <property type="gene ID" value="AA958_05760"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_05760"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1206"/>
    <dbReference type="OrthoDB" id="1996962at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="2">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="DUF397" evidence="2">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="DUF397" evidence="2">
        <location>
            <begin position="56"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH81788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="113" mass="11575" checksum="4EF33DC7012B1BA2" modified="2015-07-22" version="1">MSVEQAADTGSSPELAWVKSSYSGSGGGNCAEVAVAWKKSSYSGSDGGNCVEVAVAWKKSSYSGSDGGDCVEVAVAPERVHVRDSKDPSGPVLTVSPEAWASFVAFAATQEPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3M9</accession>
    <name>A0A0F7N3M9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">D-malate dehydrogenase (decarboxylating)</fullName>
            <ecNumber evidence="5">1.1.1.83</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_03600</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(R)-malate + NAD(+) = CO2 + NADH + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:18365"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15588"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.83"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.83" evidence="5"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014780.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_03600"/>
    <dbReference type="EnsemblBacteria" id="AKH81422">
        <property type="protein sequence ID" value="AKH81422"/>
        <property type="gene ID" value="AA958_03600"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_03600"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.758"/>
    <dbReference type="OrthoDB" id="1551125at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046553">
        <property type="term" value="F:D-malate dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011829">
        <property type="entry name" value="TTC_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02089">
        <property type="entry name" value="TTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Iso_dh" evidence="7">
        <location>
            <begin position="5"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH81422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="351" mass="37704" checksum="277EC87595A2C52A" modified="2015-07-22" version="1">MTTHRIAVIPGDGIGQEVTPAALEVLDAVGRRHGVEFAYTHLDWSCARYQREGAMMPEDGIARLRAYDAVFLGAVGAPDVPDHISLWGLLIPIRRAFRQYVNLRPVRVFEGMESPLRAAGPGDVDLVVVRENTEGEYSEIGGRLHRGFPEEMAVQEAVFTRAGVTRVLDYAFGLAGRRTGRLTSATKSNGIVHTMPFWDELVRERAAEHPKVAWDQEHIDALCAKVVLDPGRFDVIVASNLFGDILSDLTAAVAGSIGIAPSANLNPEGTYPSMFEPVHGSAPDIAGRGIADPIGAVWSAALMLDHLGHERAGAEVVEAIAATLAATDVRTPDLGGSASTEEFTRTVVARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3N2</accession>
    <name>A0A0F7N3N2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">CRISPR-associated protein Cas3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AA958_03685</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the CRISPR-associated nuclease Cas3-HD family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the central section; belongs to the CRISPR-associated helicase Cas3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_03685"/>
    <dbReference type="EnsemblBacteria" id="AKH81437">
        <property type="protein sequence ID" value="AKH81437"/>
        <property type="gene ID" value="AA958_03685"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_03685"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.776"/>
    <dbReference type="OrthoDB" id="1149839at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035011">
        <property type="entry name" value="Cas3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041372">
        <property type="entry name" value="Cas3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006483">
        <property type="entry name" value="CRISPR-assoc_Cas3_HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038257">
        <property type="entry name" value="CRISPR-assoc_Cas3_HD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006474">
        <property type="entry name" value="Helicase_Cas3_CRISPR-ass_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF5">
        <property type="entry name" value="PTHR47959:SF5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18395">
        <property type="entry name" value="Cas3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18019">
        <property type="entry name" value="HD_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01587">
        <property type="entry name" value="cas3_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01596">
        <property type="entry name" value="cas3_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51643">
        <property type="entry name" value="HD_CAS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD Cas3-type" evidence="10">
        <location>
            <begin position="1"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="834"/>
            <end position="860"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AKH81437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="940" mass="101503" checksum="0213CD9FEE3E0758" modified="2015-07-22" version="1">MADSGAVAGRLWDDWLPRQVRRSVAEALPGGEADARLVAVWLATVHDIGKATPAFACQVEDLAGVMHDHELVMPTRRLLTERSTAPHGLAGQILLDEWLEARGGFAKDARGQFTVVVGGHHGVPPDAGQVRHLRGRTDLLRTRGASEAVWRGVQTELLDAAAEACGVRDRLSAWRDVRLPQPVQVLLSATVIVADWIASNSDLFPYFPDAQGQTSAERIDAAWRGLELPAPWRAVVPPAESDDHYGTRFTLPSGAQVRPVQAAAVELARDMPEPGLLIVEAPMGEGKTEAALAVAEVFAARSGAGGCFFALPTRATGDAMFPRLRDWLVRLPDEDRERGAHSVFLAHAKSALNPHYTSLMRAPSRPLAVETDDPRTRGSHRVDGRVVHTAELVAHQWLRGRKKGMLSSFVAGTIDQLLFGALKSRHLALRHLALAGKVVVIDEAHAYDAYMGTYLDGALAWLGAYRVPVVVLSATLPAARRRELARAYAGAQAYQETLRPDGAAHVYPLLTAVSAGGRAVERAPVASGRATQVAVEALADSPEVLAERLAGELDGGGCALIVRNTVDRVRDTAAVLRARFGAEAVTVAHARFVDLDRAAKDADLRERFGPPETCSGRRPENAHIVVASQVAEQSLDVDFDLLITDLAPVDLILQRMGRLHRHKRERPPRLQTARCLITGVEPDDGGGRWTAPDGPPPVPVRGSAAVYGAWPLLRAAAVLRPYLAGGGRPVRLPTDISPLVQDAYGAALLGPTGWQDALAAAEKSDEARRVQQKKKARTYRLAAPKTPGRSLLGWIDAGVGDADDSPAGRQQVRDTEDNLEVLVVQRTADGMLRTLPWLPPDERGRRRGGLELSTDAPPDPHRARVVAASALRLPRHFSHATADRAVAELEELYIGAWQGRDCHWLAGELILALDEECQCSLAGFTLHYSPDDGLEVTRVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3W8</accession>
    <name>A0A0F7N3W8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_11305</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016058.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_11305"/>
    <dbReference type="EnsemblBacteria" id="AKH82721">
        <property type="protein sequence ID" value="AKH82721"/>
        <property type="gene ID" value="AA958_11305"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_11305"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2382"/>
    <dbReference type="OrthoDB" id="817710at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="4"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="125"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="125"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH82721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="225" mass="24763" checksum="872692171200CCAC" modified="2015-07-22" version="1">MKGRVLVVDDDTALAEMLGIVLRGEGFEPSFVSDGDRALAAFRESKPDLVLLDLMLPGRDGIEVCRLIRAESGVPIVMLTAKSDTVDVVVGLESGADDYIVKPFKPKELVARIRARLRRSEEPVPEQLAIGDLVIDVAGHSVKRGGEPIALTPLEFDLLVALARKPWQVFTREVLLEQVWGYRHAADTRLVNVHVQRLRSKVEKDPEKPEIVVTVRGVGYKAGPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3X8</accession>
    <name>A0A0F7N3X8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_07405</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015434.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_07405"/>
    <dbReference type="EnsemblBacteria" id="AKH82084">
        <property type="protein sequence ID" value="AKH82084"/>
        <property type="gene ID" value="AA958_07405"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_07405"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1552"/>
    <dbReference type="OrthoDB" id="1591999at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13579">
        <property type="entry name" value="Glyco_trans_4_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="3">
        <location>
            <begin position="18"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH82084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="452" mass="47206" checksum="A81F4B5FBF07C969" modified="2015-07-22" version="1">MVTRVLLVSTNYAPEQAGIGPYATQIAEHWVGTGHAEVHVLAGMPHYPNWRVAEDYRGVWRKEEERAGVRLHRRRHSVPARQTAVRRALYEASILAHGIAAPPRMPAPDAVVAQLPSLAGGALGARLARRHGVPYIPVVQDLMGAAAAQSGIRGGGRAAAAARAVESRVLRRAALVGVIHETFVPRVAAMGVDEKRIRVVPNWSHVTGPTRPRAEMRARLGWREGQTVLLHSGNMGLKQGLDVLVEAARTAPSLRVVLMGDGNQRAHLAALGAGLPNLDFLPPADSADFTDVLAAADVLAVTQRSSVLDMSVPSKLTSYFAAGRPVVASVADGGGTAEEMRRAGAGVVVPPEDPAALLEAVRSLAAEPEAADALGAKGPVYVREHLSSEAGLGRITALLDEALERARAGASGGAGDGAADGAAVVHNRPVIHRRKAAGESAGEAVAHTDKTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3Y6</accession>
    <name>A0A0F7N3Y6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_07370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015428.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_07370"/>
    <dbReference type="EnsemblBacteria" id="AKH82078">
        <property type="protein sequence ID" value="AKH82078"/>
        <property type="gene ID" value="AA958_07370"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_07370"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1544"/>
    <dbReference type="OrthoDB" id="1834773at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="301"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="323"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="344"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="459"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="499"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="522"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH82078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="548" mass="58770" checksum="BA0F67B95B8B157C" modified="2015-07-22" version="1">MADQTDGPRPGDGADGGDGGARVPLDETVQIRMAPLAAKAARRARAATPDPDPSPTATATATRVRRPFTPFVIPKSPAPRAVLSRALAVPLVVALVFVLPLAVAGRSQPDVRDAVFWLQLATTCYAGARLSAMVLATRRRLIQGTVWLFCYVAMGVAPLAQIVLEQTPTPVVGTRGDFTMAVALVLAGFVAFDIGALLSRHASEARLSRPRPVASVNKRRLYLLVIFAYAGSALLIASFGGPAPFFGSRQAISDELTAGGTSDSQVGSAFLRGFGTVPALLALLMMTRWLVVSRRARRQPAVVLPWAGLVLINAIVNNPISNPRYWFLTVAFALLFTAFPRSPVVYRAALAGGVALAVLLFPFADKFRYDEGGRKPTQSGSVLEPLVMKDYDQTVMFANTISYVDSGTGHTYGKQLASSAFFFVPRSVWEDKQLDSGVKVGTWMGMTNVNLSSPLWTELWLDFGPLGMAGGLLLVGYAAARTDRRFAESGHMSRDPGNVMATVVPLIAGYSFILLRGPLLQATGRIGIAVLCLALVTTFRPEEHKRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3Z6</accession>
    <name>A0A0F7N3Z6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_07505</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015453.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH82103">
        <property type="protein sequence ID" value="AKH82103"/>
        <property type="gene ID" value="AA958_07505"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_07505"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1573"/>
    <dbReference type="OrthoDB" id="552273at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.920.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037398">
        <property type="entry name" value="Glyco_hydro_64"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032477">
        <property type="entry name" value="Glyco_hydro_64_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042517">
        <property type="entry name" value="Glyco_hydro_64_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037176">
        <property type="entry name" value="Osmotin/thaumatin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38165">
        <property type="entry name" value="PTHR38165"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16483">
        <property type="entry name" value="Glyco_hydro_64"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519154" evidence="1">
        <location>
            <begin position="27"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_64" evidence="2">
        <location>
            <begin position="35"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH82103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="385" mass="40211" checksum="712B8C8E69A15744" modified="2015-07-22" version="1">MISRRRLLGGLAVASAAAGTPLVLSAARAGGAAAALDVTVVNKTGAYENSSISIYVVGNEGGRQVRLTPDGTLAPIALDDNGSDGYTDYAIPFAGSGDTSLTLPNMSGRLYVALGGKLKMKAVTDGAGNAALAYPAGWVSTDPNYPVVHDCMEFTLNDAGMFCNTTMVDMFSVPMSLHLTGADDQTTGTLKDGARQQVFDTLAGTEGFDRLVDGDGLRVIAPGHGLDTGLFDGAYLDGYVDEVWSAYAGKDLKVTTNAGTFTGRVAGDRLSFTGPADVAFDRPPTRDVLFCDGKLAAPNDGTTGPVAAILGAALNRTTLRDHADQPVTDASAFYGTDISNHYARVMHEVSEDGRAYGFAFDDVSGFASYIEDRAPQRLTLTLTPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N427</accession>
    <name>A0A0F7N427_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_15585</name>
    </gene>
    <organism evidence="3 4">
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="gene ID" value="AA958_15585"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_15585"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3280"/>
    <dbReference type="OrthoDB" id="1721089at2"/>
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        <location>
            <begin position="1"/>
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        </location>
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            <end position="246"/>
        </location>
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        </location>
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        <location>
            <begin position="205"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
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            <dbReference type="EMBL" id="AKH83395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
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    </evidence>
    <sequence length="246" mass="25659" checksum="5EAF62A042935048" modified="2015-07-22" version="1">MPRTRKATLGALGATLCATVLVGTAGTAHAQDDNGVAKESATDIANRAVSAFNDARSLHVTTERTGSGLSRTDATSLDVSADRDNNCVGTVGFAADGGSLEVVRHADKVWLKADAAWLRNNLPAGESQDVQKLEGKFLQGTTQDQGLSDLARICSINEYRDTLKDATSAGTLKKGSETTVDGKPVIDVTGKHDGMDLTLSVSTQGKPFPVRATSKGDGDSQTTNFTFDQPVPDKTPPAGETVPWGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
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                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">CNQ-509</strain>
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    </dbReference>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="102" mass="10666" checksum="3B5552E89AA70DFD" modified="2015-07-22" version="1">MLDVLDFVTAVDRIADRLRSLPQSRLRAGAAAAGLALARELSARAQRLEAPERTPYEMPAAGEFAVGDQVAVAGRDLAEALRAAGDAEGLAEALAVVRGVRL</sequence>
</entry>
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
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    </dbReference>
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    </evidence>
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            <dbReference type="EMBL" id="AKH82159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="411" mass="44556" checksum="5EC391E3229B100F" modified="2015-07-22" version="1">MGRARRAVVGACAAAVLAPVAAAGCTAGPGDGGGKAGEKSSEHADARTDARAAARKSTSAHLIGDGSTAWTGAQPAQPRVRTLAPGEKPPQFVVFSWDGAGETGDGLFQHFREIGRRYDAAMTYFLSGIYLLPESKRSLYEPPGHAPGASDIGLLSDAHIEETVDQVRGAWLDGSEIGTHFNGHFCGPTGVASWSKEEWKSEIAQAKQFVKRWKTHTGMRDAAPLPFDYDKELTGARTPCLEGADNLRAAARELGWRYDTSGVSEQVWPAKEDGLWDLSMQLVPYPGSDREELTMDYNFKVNPLTTPANAQSQMRDGLLAGFRRAYTGNRAPLIVGNHFETWHDGAYMRAVEETIKEVCPREDVRCVSFRQLADWLDAQDPRTLRALRGLEVGQAPEGGWGTLGRRGSGVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-12-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N493</accession>
    <name>A0A0F7N493_9ACTN</name>
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            <authorList>
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH81662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="260" mass="28651" checksum="7D66754ECBE890EA" modified="2015-07-22" version="1">MGFKKLFASLGAGGASVETVLNDANVVPGGVVQGEVRIEGGSVAQEVEGLSVGLQARVEVESGDNEYKQDIEFHRQRLGGAFEIQPNAVHNVSFSLDVPWETPVTSVMGQRLPGMNVGVTTELEIARAVDSLDLDPISVHPLPAQQAILDAFGGLGFRFKSADLERGHIRGTRQRLPFYQEIEFYAPQQYRGLTAVELTFLADGHQMDVVLEMDKKPGLFTDGGDSFRMFQVGLTDFQQTDWSAYLNQWISEVGSRRNWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4D9</accession>
    <name>A0A0F7N4D9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
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        <name evidence="7" type="ORF">AA958_08350</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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        </lineage>
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    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
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    </dbReference>
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AKH82239">
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    </dbReference>
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    <dbReference type="PATRIC" id="fig|444103.5.peg.1762"/>
    <dbReference type="OrthoDB" id="1510342at2"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="164"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="96"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH82239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="304" mass="32848" checksum="8E6145471D76EC76" modified="2015-07-22" version="1">MLTTASPDSRPTVHRRPGRTARSALSPVARRRLGNAGLALCVTLIVLFCLAPFYWMFVSSLKGPNDIFNNDLWPASPTLVNYEAVFSGQNNFLYALRNSAIVAGTTTILAMLIGLLSAYAFVRLRFPGKRLALGAVLAASMFPGVALLTPLFQLFSDWGWIDQYQAMIIPDVSFALPLGIWTLSVFLRELPWDLEESAVIDGCTQGQAFRKVLLPLAAPGVFTSALLVFIAVWNEYLIANAMTLTLASQPVTVAIAKFTGSSEYQQPFGTQMAAGVIVALPLIVLVLLLQRRIVAGLTAGAVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4F3</accession>
    <name>A0A0F7N4F3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glucanase</fullName>
            <ecNumber evidence="2">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_08500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase family 6.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="2"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015616.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_08500"/>
    <dbReference type="EnsemblBacteria" id="AKH82268">
        <property type="protein sequence ID" value="AKH82268"/>
        <property type="gene ID" value="AA958_08500"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_08500"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1794"/>
    <dbReference type="OrthoDB" id="1331351at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016288">
        <property type="entry name" value="Beta_cellobiohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036434">
        <property type="entry name" value="Beta_cellobiohydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34876">
        <property type="entry name" value="PTHR34876"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01341">
        <property type="entry name" value="Glyco_hydro_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001100">
        <property type="entry name" value="Beta_cellobiohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00733">
        <property type="entry name" value="GLHYDRLASE6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51989">
        <property type="entry name" value="SSF51989"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005117319" description="Glucanase" evidence="2">
        <location>
            <begin position="40"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR001100-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH82268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="335" mass="34460" checksum="3489C6478D519665" modified="2015-07-22" version="1">MRVRILRRWRRTALTGLLGAGLALAGLATAAPATPAAPAAEPDSGAAAPHASAALPGPLYVDPDSQVRRWTAANPGDWRQPVIADRIASQPQARWLSQYNPGTVQQEVAGYMSAAGDALPVLSVYGIPDRDCGGASSGGAPDLPSYQNWIRLIAAGLGDHPVVIILETDALALEDCLDQAGRDARHAALRQAVTTLKAAGPQTHVYLDGGHSAWHSPGDQAARLAASGVAEADGVFTNVSNFRTTAEEVAYGKQILAALGDPDLSLVVDTSRNGNGSNGEWCDPSGRALGANPTLTTGDDAVDALLWVKPPGEADGCAAGAGQFVPDLAYALATN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4U8</accession>
    <name>A0A0F7N4U8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aminopeptidase N</fullName>
            <ecNumber evidence="4">3.4.11.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Alanine aminopeptidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Lysyl aminopeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">AA958_06040</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal amino acid, Xaa-|-Yaa- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide.</text>
            <dbReference type="EC" id="3.4.11.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.2" evidence="4"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015190.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_06040"/>
    <dbReference type="EnsemblBacteria" id="AKH81837">
        <property type="protein sequence ID" value="AKH81837"/>
        <property type="gene ID" value="AA958_06040"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_06040"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1262"/>
    <dbReference type="OrthoDB" id="771837at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012778">
        <property type="entry name" value="Pept_M1_aminopeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="SSF63737"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02412">
        <property type="entry name" value="pepN_strep_liv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase_M1_N" evidence="15">
        <location>
            <begin position="85"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M1" evidence="13">
        <location>
            <begin position="231"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="ERAP1_C" evidence="14">
        <location>
            <begin position="523"/>
            <end position="835"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AKH81837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="850" mass="93345" checksum="5E81F1AEAD21988F" modified="2015-07-22" version="1">MPALTRAEAQLRADLLDVRHYAVDLDLTRGEEVFGSSTVITFAARTAAETFVEIRPAELVRATLDGRDLETGALDDNRLALQLAEGEHELRVEAVMSYSRTGEGMHRFTDPADGETYVYSQLFLDDVQRAFAAFDQPDLKAVFDVSVTAPAGWTVLGNGIAHQEADAGPGAEPAAGVRWRLTTTPPLATYLVAVAAGPWHSVHTEHAGLPFGLHCRRSLAAHLDADAEELFDVTRRCFDRYHERFAEPYPFDSYDQAFVPEFNANAMENPGLVTFRDEFVYRSAVTDTERQTRAMVIAHEMAHMWFGDLVTLRWWDDIWLNESFAEYMGYQILAEATRFTGTWTDFAIARKSWGYDADQRPSTHPVAPPRVPDSAAALQNFDGISYAKGASALRQLVAWMGEKDFFAGLDDYFSRHRFGNATLADFIASMDRASDRDVPEWADAWLRTTGVDTFRPEIWQGEDDVWVLEVEHAGRRPHRLDVGLYDEVPGEPGRMVLRERAAQEFAADLGLKSASAEGRVPDLVLVNDGDLTYAKIRLDEGSWETALRCLSGIPDPLSRAVLWNAARDMVRDAELPPADYLRAAAAHLPAEDDLAVVQGVLGFARGPVAGAYVPDADRPAARATVAETCRELLRRTDDDHDPGLRLAAVRALIDCADEPDEVRDWLAAGTVPGGPVLDPDLRWRCLVRLAVLGATTPERIEAEVARDPGASAQEGAARCLAALPDAGAKAAAWESMYGGAAGAAELSTYLFTATALGFWQPEQREVLAPYVPRWFAETPGLAGRRGPAIAEAAGRSGFPRGFVDAETLRLGRECLERDDLVPALRRRLADQLDDLGRALRVREAADAGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4X0</accession>
    <name>A0A0F7N4X0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glutamate synthase</fullName>
            <ecNumber evidence="6">1.4.1.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">gltD</name>
        <name evidence="6" type="ORF">AA958_06120</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis.</text>
    </comment>
    <dbReference type="EC" id="1.4.1.13" evidence="6"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015205.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_06120"/>
    <dbReference type="EnsemblBacteria" id="AKH81852">
        <property type="protein sequence ID" value="AKH81852"/>
        <property type="gene ID" value="AA958_06120"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_06120"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1278"/>
    <dbReference type="OrthoDB" id="671513at2"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004355">
        <property type="term" value="F:glutamate synthase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006537">
        <property type="term" value="P:glutamate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
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        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
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    <sequence length="486" mass="52204" checksum="ED2ACD93975DCB49" modified="2015-07-22" version="1">MADPKGFLTTGREVAETRPVAERVKDWNEVYVPGSLLPVISKQAGRCMDCGIPFCHNGCPLGNLIPEWNDYAYREDWTAASERLHATNNFPEFTGRLCPAPCETACVLGINQPAVTIKNVEVTIIDKAWEAGAVTPQPPERLSGKTVAVIGSGPAGLAAAQQLTRAGHTVAVYERADRIGGLLRYGIPEFKMEKRHINRRVEQMRAEGTKFRTGVEIGRDIDGAKLRKRYDAVVVAAGATTARDLPVPGRELAGIHQAMDYLPLANKVQEGDYVTPPISAEGKHVVVIGGGDTGADCVGTAHRQGAASVTQLEIMPRPSEERPEGQPWPVYPMTYKVTSAHEEGGERVYSVSTTHFEGDEGGNVAFLHLVEVRFEDGGFKPVPGTERKIPAELVTLAMGFTGVDRENGLVEQLGLELDARGNVARDADYATSVPGVFVAGDAGRGQSLIVWAIAEGRSAARGVDRMLTGASDLPAPIRPTDRALVV</sequence>
</entry>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
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        </location>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="532" mass="57705" checksum="5E7653F8ADA06D13" modified="2015-07-22" version="1">MPRWLKLLIGLLAAAAVVAVICGGVKIYEEAQEPDTCADGVEKIDGECIGVTAEGYDFGTPEIRDVARAIATENNRVEDEPHVTVAMVLPLQSDNPATRREIRSDLQGAYLGQRHVNKGVGEPPKIRLVLANPGRYYRHQKQVVDTLLDMAESRSDRLRAVTGFNLSLDTTEAAIKRLTEHRIPVLGSRISGDRLANKDNADGTDRPTFPGLARIISTNGAAARALADFNGEQGRRDERTVLVYDSREDSYVESLADAFSSIEEVGPAGQAAIPFESPALDEPGTTGNQFGHIANSICGSRADTIYFAGRTLHLRIFALKLAAVECGTRKYTIISGSDAASLRQNLSEQDWEGLRGEDGKPKVRVQYAAPAHPDAWDTEIKEWPEEHGDEPLPQYLTEPRDALQELEDEIKAVKDENISLGSAPDLRDSRTMLVYDGLVTIGEALHQVQQGGSDDVPSTRDVGGQWPLLQSQLRIRGSSGLICLTSSGNPYDKPAAVVQLDPGTEGRGKLKYVGLGWPTGDPQPKNCVIPSG</sequence>
</entry>
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        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Leipoldt F."/>
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                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
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    </dbReference>
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        </location>
    </feature>
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        </location>
        <ligand>
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        </ligand>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH82499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="241" mass="26501" checksum="AFE42CCD7B706A93" modified="2015-07-22" version="1">MTAAIDVTGLRKRYGDVRAVDGVSFEVREGEFFGLLGPNGAGKTTTLEMVEGLRRPDEGRAVLLGEPSWPRNQALLRRIGVQLQASAFFEKLTAREQIRTFASLYGISDDRADAMLAEVGLTEKAGTREDKLSGGQAQRLSIACALVHDPELVFLDEPTTGLDPQARRNLWDLLRGINAAGRTVVLTTHYMDEAEVLCDRVAVMDAGRILRIGKPAELAAELEVDSLEDVFLQLTGREYRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N550</accession>
    <name>A0A0F7N550_9ACTN</name>
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        </submittedName>
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    </gene>
    <organism evidence="8 9">
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        <lineage>
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            <taxon>Actinobacteria</taxon>
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    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AKH82509">
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        <property type="gene ID" value="AA958_10020"/>
    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017187">
        <property type="term" value="P:peptidyl-glutamic acid carboxylation"/>
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    </dbReference>
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        <property type="entry name" value="HTTM"/>
    </dbReference>
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        <property type="entry name" value="VKG_COase"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="304"/>
            <end position="326"/>
        </location>
    </feature>
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        <location>
            <begin position="40"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="348"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="366"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH82509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="386" mass="42576" checksum="849922F4344A6310" modified="2015-07-22" version="1">MHSDRTPAPSPPTRRGVRTAGSRPDRLLERVGGMRMMLVEREVSLHAAAVLRIGYGTLYFAFLLREFPHRDELWGPEAPWTPDLARQLFDQTSWTSFLTLSDDPLYFELCYGAALLTSLLFAAGWRTRATSLLFAFVVTSFHARAIFSTDGGDNIVLLMAVYLCFTACGRRWSLDARRACRARGRGTAKGNLSMAPWLCQLETARRQVTTLLHNCGMFVIAAQVCIVYGAAGLYKVQGDTWGNGTALHYVTHLDLFQPWPALSGLASEHLQLLALAGYMAVLLQISFPFVLFGRLKYPVLVMTLGMHLGIAVLMGLPFFSGAMIIADAVFLPDRFYRAAEAGLHSLRRRTNTEDAVPPPGKTTSVPAQHLPGTQTPATTDPARTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N566</accession>
    <name>A0A0F7N566_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_10270</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_10270"/>
    <dbReference type="EnsemblBacteria" id="AKH82548">
        <property type="protein sequence ID" value="AKH82548"/>
        <property type="gene ID" value="AA958_10270"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_10270"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2164"/>
    <dbReference type="OrthoDB" id="1515911at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="91"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="115"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="3">
        <location>
            <begin position="6"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="3">
        <location>
            <begin position="145"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH82548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="318" mass="32972" checksum="9EF714BBAC8A7A02" modified="2015-07-22" version="1">MRPLHIALAVLVAFFWGLNFVVIEVGLDHFPPLLFTALRFLVAALPAVFLVGRPQVAFKWILAVGLVLGVAKFGLLFVGMEQGMPPGLSSLVLQIQAVFTACIAAAVLGERPGRVRLAGMGVALCGVALAAVDEGGSGPLGAFAIVLAAAFCWGISNVIMRKAAPPDGLRFMVWVSCVPVLPLLALSLVFEGPERDWEALRSLDWAGAGAVVYIAWIVTIFGFGVWGYLLRTYDASTVAPFSLLVPVAGMSSAALFLGEEITGLRWVAALLLVGGVAVTSLSGRRAGRTAGPRDGAVPHRPAVPAPSGGASAPPSGSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5B1</accession>
    <name>A0A0F7N5B1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_10625</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015944.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH82603">
        <property type="protein sequence ID" value="AKH82603"/>
        <property type="gene ID" value="AA958_10625"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_10625"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2235"/>
    <dbReference type="OrthoDB" id="1938490at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519140" evidence="3">
        <location>
            <begin position="29"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH82603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="199" mass="20960" checksum="D09F97D1427071B5" modified="2015-07-22" version="1">MRPVRVCLAAVLLLTGGGAVSCATDAFAQGEVTVTPYRVQRGDPVQVSTGACRGDFASATSEAFEAPVNLRPENFGGLTGRGKIKWTARAGTFPVWVDCDGGKRVARGRVVVEERHQRPEHWKNNWHHEPWSPVTAGGGGTAKKTDPAQAQEQGKNGSVPVLPLALVGGGAAVLALSFVRRRTRAAASRGPDGGTPEDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5M1</accession>
    <name>A0A0F7N5M1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptide chain release factor 2</fullName>
            <shortName evidence="4">RF-2</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 7" type="primary">prfB</name>
        <name evidence="7" type="ORF">AA958_11165</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="4">Methylated by PrmC. Methylation increases the termination efficiency of RF2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_11165"/>
    <dbReference type="EnsemblBacteria" id="AKH82698">
        <property type="protein sequence ID" value="AKH82698"/>
        <property type="gene ID" value="AA958_11165"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_11165"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2353"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016149">
        <property type="term" value="F:translation release factor activity, codon specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PCRF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004374">
        <property type="entry name" value="PrfB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03462">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00937">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="SSF75620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00020">
        <property type="entry name" value="prfB"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RF_PROK_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0488">Methylation</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RF_PROK_I" evidence="6">
        <location>
            <begin position="228"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="3"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="modified residue" description="N5-methylglutamine" evidence="4">
        <location>
            <position position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH82698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="357" mass="39828" checksum="CC4138916CEF5C47" modified="2015-07-22" version="1">MESIEAVLDLDRLRTDIAALEEEAAAPALWDDPENAQRVTSRLSLLQGQLRKIEELRGRIDDLEVLFELAESEGDADTQREAEGELSDVRRAVEELEVRTLLSGEYDQREAMVNIRAEAGGVDAADFAEQLQRMYLRWAEHKGYPTEVLDTSYAEEAGIKSTTFAVKAPYAYGTLSVEQGTHRMVRISPYDNQGRRQTSFAGVEVLPVVEQTDHIEIPENEIRIDVFRSSGPGGQSVNTTDSAIRITHLPTGIVVSCQNEKSQIQNRAAAMRVLQARLLAKRKEEEQAKMNALKGDSAGSWGNQMRSYVLQPYQMVKDLRTTHEVGNPQAVLDGEIDGFLEAGIRWRKQQEQAAAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5X1</accession>
    <name>A0A0F7N5X1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_15755</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016733.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_15755"/>
    <dbReference type="EnsemblBacteria" id="AKH83421">
        <property type="protein sequence ID" value="AKH83421"/>
        <property type="gene ID" value="AA958_15755"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_15755"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3320"/>
    <dbReference type="OrthoDB" id="1320028at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="2">
        <location>
            <begin position="30"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH83421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="516" mass="54193" checksum="863BDEC5578512EE" modified="2015-07-22" version="1">MNGVEKWTSERSKASGSDFLQLDVGDAPAGGMADWLAWRLREAIADGRLAVGGRLPPTRVLAAELRVSRGVVTEAYRRLTEDGHVEGRRRGGTVVVAAPVDEGPGPRAAGQEQPAVLFPAAPGPEAFEVLRAAPASIDLTPGLPDLAAFPRAAWLRAERAVLGELSAADLGYGDPHGTPALRRAVAGWLARNRGIRADPDDVVIVAGTAQALTLLHPVLRTDGVGAVAVEDPGSLGTRQHLENGGLDIVPVPVDADGIRVDALRATGARAVLLTPAHQFPTGAVLSGERRRELLRWAEDGGGLVLEDDYDAEHRYDRPPVPALRAMLAERVCYMGSVSKLLAPALRVGWVVPPPGYRDALVNAKRFTDLGNAVLPQLVLARLMESGELERHLRLLRGRHRRRRDAMIAAIAEHLPGAVVHGAAAGLHLTVTFDGAGGETAAEAVGAGPAGRADAGLTGVTDTELAAAALSCGVKVQPLSWHRLRTGPPGLVLGYAASHPDAVTEGVRLLGRALRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5X6</accession>
    <name>A0A0F7N5X6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_15815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016743.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_15815"/>
    <dbReference type="EnsemblBacteria" id="AKH83431">
        <property type="protein sequence ID" value="AKH83431"/>
        <property type="gene ID" value="AA958_15815"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_15815"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3333"/>
    <dbReference type="OrthoDB" id="2055010at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="150" mass="16255" checksum="D53FF0B1AF6F06D6" modified="2015-07-22" version="1">MTDLAIRRATAADVPAIVAMLADDPLGATRESPGDPAPYEDAFVRIDADPGQHLVVAERDGRVVGTVQLTVIPGLSRRGATRALIEAVRVHREERGGGLGTQLIEWAVEEARRRGCAVVQLTSDATRTDAHRFYERLGFAASHVGFKRML</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6D1</accession>
    <name>A0A0F7N6D1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_12860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016302.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_12860"/>
    <dbReference type="EnsemblBacteria" id="AKH82968">
        <property type="protein sequence ID" value="AKH82968"/>
        <property type="gene ID" value="AA958_12860"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_12860"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2705"/>
    <dbReference type="OrthoDB" id="1194694at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015815">
        <property type="entry name" value="HIBADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000103">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_binding_2" evidence="1">
        <location>
            <begin position="11"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="293" mass="30191" checksum="CC52C73AC77D6EFF" modified="2015-07-22" version="1">MTPHTQDKTPVTLLGLGAMGTALARAWLAAGHPTTVWNRTPARAGALAAEGARRADGPAAAVAASTLVVVCLLDDVSVGEVLAGTDLAGKDVVNLTTSTPAQARARAAWASDRGARYLDGGIMAVPPMIGVPETGGYVLYSGPRDVFDHHRDTLAVPAGATYAGEDPGFAALLDVALLSAMYGMFAGTTHAFALIRRENLDPAAFAGLLTGWLTAMAPAAHAIAAGLTADAAPAEEVSSLAMQVAGTPTFLDTARQQGVSPELLAPYFELMRRGLTEQNEAKNPKGLVDLLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6D5</accession>
    <name>A0A0F7N6D5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_12890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016307.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_12890"/>
    <dbReference type="EnsemblBacteria" id="AKH82973">
        <property type="protein sequence ID" value="AKH82973"/>
        <property type="gene ID" value="AA958_12890"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_12890"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2712"/>
    <dbReference type="OrthoDB" id="2037436at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009412">
        <property type="entry name" value="DUF1062"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06353">
        <property type="entry name" value="DUF1062"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH82973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="175" mass="19709" checksum="189AE5D10B2D5719" modified="2015-07-22" version="1">MPTCLPLVRRRCHACASGRFRANGKFRVNAHHKLLDVWLLALCTGCGATAKLTVLERVNVRSVRPELLARLHHDDIHLAATLLQDPALQRRNRVALDWTGAWRLDTGGTDHLHREVIDVTVRFAARIPVRPMRLIADGCALTRAEAERLMDEGRLIAAVRLNARLTGDFTFTLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6I4</accession>
    <name>A0A0F7N6I4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">XRE family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_12780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016288.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_12780"/>
    <dbReference type="EnsemblBacteria" id="AKH82954">
        <property type="protein sequence ID" value="AKH82954"/>
        <property type="gene ID" value="AA958_12780"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_12780"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2685"/>
    <dbReference type="OrthoDB" id="1060221at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="18"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="285" mass="32464" checksum="6051F3221E1E25BA" modified="2015-07-22" version="1">MASNVNPTVRRRRLGQELRRLREQKNMTAEQVADRLLVSQSKISRLENGRRSISQRDVRDLCGVYEVEDERIVNSLMQMAKESRQQGWWNAFGDVPYSVYIGFETAAASLRIYQSLVVPGLLQTREYAAAVIAGSSPEVNAADVEKRVNVRMRRQDRIKGTEQPLRLWAVFDEAALQRVVGSVQVMREQLEHLIEVSQLPHVTVQVLPFETGAHPGVTGQFAILEFPEESDSSVIYLEGVTSDLYLEKSDDVHNYSVMYEHLRAQALNPEQTRKFIADTAKKYAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6Y5</accession>
    <name>A0A0F7N6Y5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Amino acid ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_10585</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015938.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_10585"/>
    <dbReference type="EnsemblBacteria" id="AKH82597">
        <property type="protein sequence ID" value="AKH82597"/>
        <property type="gene ID" value="AA958_10585"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_10585"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2228"/>
    <dbReference type="OrthoDB" id="1523519at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010065">
        <property type="entry name" value="AA_ABC_transptr_permease_3TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043429">
        <property type="entry name" value="ArtM/GltK/GlnP/TcyL/YhdX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014341">
        <property type="entry name" value="Ectoine_EhuD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30614">
        <property type="entry name" value="PTHR30614"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03003">
        <property type="entry name" value="ectoine_ehuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01726">
        <property type="entry name" value="HEQRo_perm_3TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="15"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH82597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="217" mass="24001" checksum="14F7A4BDBCF57861" modified="2015-07-22" version="1">MTFDWEVVEDFMPRFLDGVLVTLQALALGTLIAFALGLVWAMAQRAPQRWVRWPVTAVTEFIRNTPLLVQLFFLFYVVPQWGPSMSPLTTGIVGLGLHYSTYTAEVYRAGIDGVPVGQWEAAKALSLSRGRTWSSVILPQAIRRVVPALGNYVVAMLKDSPMIAVIGALDMLGEARQFSNETFTTEAITIVGVAFIVIAYPASLLIRVLERRLVNNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N768</accession>
    <name>A0A0F7N768_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA (cytosine-5-)-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_18795</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = a 5-methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:13681"/>
            <dbReference type="Rhea" id="RHEA-COMP:11369"/>
            <dbReference type="Rhea" id="RHEA-COMP:11370"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:85452"/>
            <dbReference type="ChEBI" id="CHEBI:85454"/>
            <dbReference type="EC" id="2.1.1.37"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.37" evidence="2"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017203.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_18795"/>
    <dbReference type="REBASE" id="113746">
        <property type="entry name" value="M.Ssp509ORF18795P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH83906">
        <property type="protein sequence ID" value="AKH83906"/>
        <property type="gene ID" value="AA958_18795"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_18795"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3946"/>
    <dbReference type="OrthoDB" id="1178320at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003886">
        <property type="term" value="F:DNA (cytosine-5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001525">
        <property type="entry name" value="C5_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00145">
        <property type="entry name" value="DNA_methylase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00105">
        <property type="entry name" value="C5METTRFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51679">
        <property type="entry name" value="SAM_MT_C5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0680">Restriction system</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="226"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH83906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="418" mass="44744" checksum="4DCEACEBD9EAAF22" modified="2015-07-22" version="1">MILDLFAGPGGWSQALHVLGVRDVGLEWDAFACRTRAAAGHLTIRTDVAAYPTWPFPGRTRGLIASPPCQAWSTAGKRLGLVDQPLVHQAVEDLAAGRDTRARLLSACRDERSLLAAEPMRYLHALNAAGEPEWIAMEEVPHVLPLWQQYAAILRTWGFSVWTGILNAADYGVPQTRRRAILLASRIRTAHPPAPTHAHLADPESLFGPGRARWVSMAQALGWGATDRPVPTVCAGGGPGGGPEPFPSGSRKTLTDARERGTWTHPADESTPSPGRRGARPPERHEAGDSRAASAPVAASPGRARRWSWSLRSNTQAHATTRTIDEPAGTLFFGHRANECTWIATPADAGETAAPEPIRIGVHEAGVLQTFPADYPWAGNKGQQFSQIGNAVPPLLAGHLLAPHLGATLDPDDFTLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7C9</accession>
    <name>A0A0F7N7C9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">N5-carboxyaminoimidazole ribonucleotide synthase</fullName>
            <shortName evidence="3 5">N5-CAIR synthase</shortName>
            <ecNumber evidence="3 5">6.3.4.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3 5">5-(carboxyamino)imidazole ribonucleotide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">purK</name>
        <name evidence="7" type="ORF">AA958_11490</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).</text>
    </comment>
    <comment type="function">
        <text evidence="5">Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)- to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 5">
            <text>5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ATP + hydrogencarbonate = 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + ADP + 2 H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19317"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58730"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 5">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route): step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the PurK/PurT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.18" evidence="3 5"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_11490"/>
    <dbReference type="EnsemblBacteria" id="AKH82752">
        <property type="protein sequence ID" value="AKH82752"/>
        <property type="gene ID" value="AA958_11490"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_11490"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2418"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00942"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034028">
        <property type="term" value="F:5-(carboxyamino)imidazole ribonucleotide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004638">
        <property type="term" value="F:phosphoribosylaminoimidazole carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01928">
        <property type="entry name" value="PurK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
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        </location>
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    <feature type="binding site" evidence="3">
        <location>
            <position position="96"/>
        </location>
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            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
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        </location>
        <ligand>
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        </location>
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        </location>
        <ligand>
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        </ligand>
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        <location>
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            <end position="261"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH82752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="376" mass="40549" checksum="2A85C78DB226DA19" modified="2015-07-22" version="1">MIGGGQLARMTHEAGIPLGIRFKLLSGTRTDSAALVAGDTVVGDYRDLDTLRDFARGCDVITFDHEHVPAEHLRVLQAEGVAVRPGPDALVYAQDKGAMRARLTELGIPCPRHRIVADPADVARFAREGGGFPVVLKTVRGGYDGKGVWVVRTEEDAAPPFRAGVPVLAEELVGFRRELAANVVRSPSGQAVAYPVVESIQVDGVCDTVLAPAPGLAPEDAVRTQQLALRIAMELDVVGHLAVELFEAEGPDGEPRILVNELAMRPHNSGHWTQDGAVTSQFANHVRAVLDLPLGDPRPRAPWTVMANVLGGDYPDMYPAYLHCMARDPGLKIHMYGKDVKPGRKVGHVNTYGDDLADVRARARHAADYLRGTITE</sequence>
</entry>
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        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
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            <end position="74"/>
        </location>
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            <end position="137"/>
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            <end position="258"/>
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    </feature>
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            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AKH84625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="322" mass="33597" checksum="F1B244F68050BECE" modified="2015-07-22" version="1">MGRGARVFGAVCCALLALLSLLWIGRDVGVAASLPDLWWSWAGSPDAVPENHWGTSLYDPVLVGVYAVAGVTALHATAAAGALATAGAATILLRAPALWTLTADWMQGVDQDLRNRALLSAGVAVTLGAVLLISVAAGRRPSEATGAGYLLPDEQPPRRPARGAAATGMVFLAAAAVAFAAWELREAARTGWEAYGHRLTGEYTSWALLQPPLAYGKWATAAMCFAAAVAAARRAPLSRPLGMTAGAFVLGWGAADTSRYLKDEVFENFGALGAEHQLQASTGIGLLLAGFVILFALAGRGERDPVAEPLSRWQEPSSQPPW</sequence>
</entry>
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        <lineage>
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        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
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    </dbReference>
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            <end position="129"/>
        </location>
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        <location>
            <begin position="75"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH84081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="151" mass="16815" checksum="797C288AD8F648CD" modified="2015-07-22" version="1">MSREWSMGYVMGYRSVPLVRVHVRRQLALWRWGGDAQDAALVVSELVTNAIQYGRKIGRRVWVRLAVREDGSLVIDVSDPQTTQPPRMPDASPPGPEDERGRGLFLARGLGAEVSWFPREFAGKTVRATLEPARVPGVPRDEEVGGTLRLP</sequence>
</entry>
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    <name>A0A0F7N7W4_9ACTN</name>
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        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Albersmeier A."/>
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                <person name="Winkler A."/>
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                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
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        <text evidence="1 5">Belongs to the bacterial ribosomal protein bL34 family.</text>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-UniRule"/>
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    </dbReference>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH83494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="45" mass="5282" checksum="7E86DC518767CDEF" modified="2015-07-22" version="1">MSKRTFQPNNRKRAKTHGFRLRMRTRAGRAIITARRTKGRARLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N824</accession>
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        <recommendedName>
            <fullName evidence="2">HisKA_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
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    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017992.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_23865"/>
    <dbReference type="EnsemblBacteria" id="AKH84740">
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            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH84740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="394" mass="41856" checksum="119EF23FF0ABA3FF" modified="2015-07-22" version="1">MSTAEGFVRRALLTPPQLRLLLAAGFVFVVFKSLRAALTEQAGLLTSPAASAVVAGVLCAVLPLCRRMPVPVAAVTGAGFLLESQVWPVFLALYGVTLWRPRGTAIALTGAVFVPAAFGPFRELVGMPQVVLFPCAILAVPLAVGLAVRSQRDLAGSLARQLEHLEAVNRLRDEQVRMAERARIAREMHDVLAHRLSLLVLHTGVLQRRGDTVPEPVRESLDLLRTTSAHALDDLRDLLGALRDHEGPVPLAPTADDLPALIAESERAGTRVRARTDDLAGLPAAVRLAAHRIVQEALTNARKHAPGAPVDLTVTVTRTRVAIRAENECGAAPERRDGPSRGYGLVGTAERVAALHGELTTGHTGDGRFVLTADLPVPVHPVEEPSALSAAAAR</sequence>
</entry>
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                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">CNQ-509</strain>
        </source>
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    </dbReference>
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            <begin position="44"/>
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    </feature>
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        <location>
            <begin position="78"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="103" mass="11343" checksum="99E05A1C0B969AA1" modified="2015-07-22" version="1">MTPKPNPAVRYTAMRLGVFAASFVILAVLVRVGALPAGLGDSNYLWVMLLSIVVSAPLSFVLLRRQRDEMSEQIVGRVQRSKERLAANRSREDEADDEARGTA</sequence>
</entry>
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    <accession>A0A0F7N8D0</accession>
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                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH83723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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        </source>
    </evidence>
    <sequence length="321" mass="35939" checksum="EFFE1AE390B900F9" modified="2015-07-22" version="1">MSHPHHTTGLCAPGRKLYASALRSGRISHEATATAPCLFDLDLLRPEPGDTQWLVPTPPTQALAGLVEPLERELGEYRLFVSALADTVEKLTSLDPDDPATSAFTVWTGKERIDAALARALEDCTEQFLAIQPASGRTNWNPATMRTTTHRVRRMSERGVTQRILYNHTYRHHPSQLAYLDELSDTGLEVRTLEVMPERLLIVDRDIAFLPAQPSREVAMEIRHPGLVWFLRAIFEYFWELGVPWGRQPPEHDTRGGITGVQRSIARLLVEGHLDEAIARRLGMNVRTCRAHIAKLSTALGSDSRAQLGYLIARSSMLDRA</sequence>
</entry>
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    <accession>A0A0F7N8F2</accession>
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                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="P_Acid_Pase_2/haloperoxi_sf"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
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        </location>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="50"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH83763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="192" mass="19848" checksum="D0776E33DA4B2FAA" modified="2015-07-22" version="1">MNDELYRDVTSLARRTPDWLHTLAEYGTDAGLLLLAALFAAAWWAAPRRAPVVAGAAGTAGAYGLSELLKVWVERERPCRAVHGAAAPLADCPPPGDWSFPSNHATIAGAAAVALAVAWPRIAGWVLPFAVVLAASRVFVGVHYPLDVAAGLALGAAVAAPCAALARVRIGGAGSRRRRGADTLTGARSPIE</sequence>
</entry>
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    <accession>A0A0F7N8V1</accession>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018211.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH84960">
        <property type="protein sequence ID" value="AKH84960"/>
        <property type="gene ID" value="AA958_25205"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_25205"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5312"/>
    <dbReference type="OrthoDB" id="1450979at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH84960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="356" mass="38080" checksum="B19DE4EE5EDBAC48" modified="2015-07-22" version="1">MAQRQGALPPGTRLVHIGPHKTGTTTLQGAFHRSRRALAAHGVRYAGASRQPAHAAAAIAGGTPVHSLEAPSMAHWEKLCAEVAGAGRRRRVVVSSERFANADAAAVRAVVDGLGGERVHVVVTLRPLVKILPSQWQEYIKSGHQHTYDKWLDGMLRRPPYRKPTPSFWRRHRHDELVARWADAVGADRLTVVVVDQAEPLAHLRAFEGLLGLPDGLLEPEQDGFTNRSLTAGEVEVLRLVNRELARAERPAPERKLVREALVRCLRGAHVPKDPAERIATPAWARRAAAEVSAEMVAGIRKSGVRVVGDLDTLVPEPAAGDSAGPVESAAAEPSLPVGAAYAAVTGALLAAAEAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8X9</accession>
    <name>A0A0F7N8X9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">L-serine dehydratase</fullName>
            <ecNumber evidence="9">4.3.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AA958_25370</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>L-serine = NH4(+) + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:19169"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="EC" id="4.3.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the iron-sulfur dependent L-serine dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.17" evidence="9"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018241.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_25370"/>
    <dbReference type="EnsemblBacteria" id="AKH84990">
        <property type="protein sequence ID" value="AKH84990"/>
        <property type="gene ID" value="AA958_25370"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_25370"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5348"/>
    <dbReference type="OrthoDB" id="225730at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029009">
        <property type="entry name" value="ASB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004644">
        <property type="entry name" value="Fe-S_L-Ser_mono"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005130">
        <property type="entry name" value="Ser_deHydtase-like_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005131">
        <property type="entry name" value="Ser_deHydtase_bsu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03313">
        <property type="entry name" value="SDH_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03315">
        <property type="entry name" value="SDH_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143548">
        <property type="entry name" value="SSF143548"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00720">
        <property type="entry name" value="sda_mono"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="7 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 9 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SDH_beta" evidence="11">
        <location>
            <begin position="4"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="SDH_alpha" evidence="10">
        <location>
            <begin position="193"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AKH84990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="465" mass="49319" checksum="00C8112035387696" modified="2015-07-22" version="1">MAISVFDLFSIGIGPSSSHTVGPMRASRMFARRLKNEGLLAHTAAVRAELFGSLGATGHGHGTPKAVLLGLEGHSPRTVDIEWAEGEVERIRATGRLHLLGAEIGRDHEIPFDASADLVLHRRRSLPYHANGMTLAAYDADGGTLLAKTYYSVGGGFVVDEEAVGEDRIKLDDTVLKHPFRTADEMLRRTRETGLSLSSLMLENERAWRTEAEIRAGLLEIWRVMRDCVARGTSREGILPGGLKVRRRAAGEARQLRAAGDPAAHAMEWVTLYAMAVNEENAAGGRVVTAPTNGAAGIIPAVLHYAADFVPGRDSRAGEEDTAVRFLLAAGAIGMLFKENASISGAEVGCQGEVGSACSMAAGGLAEILGGTPEQVENAAEIGIEHNLGLTCDPIGGLVQIPCIERNGMAAVKAITAARMALRGDGQHFVSLDKAIKTMKETGADMKVKYKETARGGLAVNVVEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9M0</accession>
    <name>A0A0F7N9M0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_15600</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016709.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_15600"/>
    <dbReference type="EnsemblBacteria" id="AKH83397">
        <property type="protein sequence ID" value="AKH83397"/>
        <property type="gene ID" value="AA958_15600"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_15600"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3284"/>
    <dbReference type="OrthoDB" id="969875at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="3">
        <location>
            <begin position="11"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH83397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="347" mass="36714" checksum="8FF01EBEBC6CADA5" modified="2015-07-22" version="1">MRPTTGWRADSATRTLRRTALERRELRPDDIAVRVEYCGVCHTDLHALHAHESDADGVLVPGHEFTGVVTEAGSAVSGFSPGAPVAVGNIVDSCRICRMCQAGQENFCREFPTLTYGGADRQDGTTTLGGYSREYVVSHRFAHHLPAGLDAAAAAPLLCAGVTVWEPLQALGVGPGSTVAVAGLGGLGHLAVKMATALGATTSVISRTPDKAGEARALGARGFVVSTDSTQTDTVRDRFDVVIDTISAPHDLAPYLRMTAMDGTLSHLGHLGPVTVDTLDLLIGRKKLSSAGSGGRPSTGAMLRFCAEHDITADIELLPSSQVNTALERLERNDVRYRFVLDMSDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NA37</accession>
    <name>A0A0F7NA37_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphate-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_16665</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in the system for phosphate transport across the cytoplasmic membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the PstS family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016877.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_16665"/>
    <dbReference type="EnsemblBacteria" id="AKH83572">
        <property type="protein sequence ID" value="AKH83572"/>
        <property type="gene ID" value="AA958_16665"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_16665"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3507"/>
    <dbReference type="OrthoDB" id="1222928at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042301">
        <property type="term" value="F:phosphate ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024370">
        <property type="entry name" value="PBP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011862">
        <property type="entry name" value="Phos-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12727">
        <property type="entry name" value="PBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02136">
        <property type="entry name" value="ptsS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0732">Signal</keyword>
    <keyword evidence="2 4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027163119" description="Phosphate-binding protein" evidence="4">
        <location>
            <begin position="34"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="PBP_domain" evidence="6">
        <location>
            <begin position="66"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="319"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH83572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="345" mass="36592" checksum="25AAE8F54005E90D" modified="2015-07-22" version="1">MSPTKTKRTAARLGVLLLAPAAVASLVSCGAESEAGPAEDETARPAGTVTIDGSSTVEPLTKLAGERFGGREPGVRVEVGASGTGGGFDKFCAGETDISDASRPINDFEKETCANWDVPYRELTIANDALTVVVPRANDWIDCITTDQLKRIWEPGSALASWREVDPTFPDEPLQLYGPDTDSGTFDYFTEAINGEEKASRADFTPSSDDNTLVKGVAEHSGGLGYFGFTYFDENRDKLRALEIDAGGGCVAPSTASVQDGSYKPLARPLFLYPSAKALERPEVEAFVEFYVDSHTDFASEAGYIPLSDVQEKELERDLARLKEHSGRPGGAGDTGGDSGGSGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NA48</accession>
    <name>A0A0F7NA48_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_24960</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018167.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_24960"/>
    <dbReference type="EnsemblBacteria" id="AKH84916">
        <property type="protein sequence ID" value="AKH84916"/>
        <property type="gene ID" value="AA958_24960"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_24960"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5260"/>
    <dbReference type="OrthoDB" id="1828250at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="145"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="215"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="292"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH84916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="321" mass="33195" checksum="03C8249F0E629317" modified="2015-07-22" version="1">MSYPPQPSAPAPGAPPVPGAAPGPVPGAAPPAGPPPGGGYSSPIPIVRTHLGHAFASEWTKIRSVRSTMWTLGVMLLLVVGVGFLIALAMSSDEWVGAPLLSGGLFGLMLGQICIVTLGVLVITSEYGTGMIRTTLTASPQRWRVLAAKAVVFFVLAFVLTTAACAITALVHAAVLGGQTVPEYEMNEPMFKDSVSDSGELIATSSQWFDATVGAALYVSLLGLLALAVGAILRHSAGAITTMVGFILLPLIIALFMQAESLRDVQRKLIEFSPLSGLASLYGIPFFDDGDIGGWGLLGLLAAVTGGMLLLAFALLSKRDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-10-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NA74</accession>
    <name>A0A0F7NA74_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_21490</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017607.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH84344">
        <property type="protein sequence ID" value="AKH84344"/>
        <property type="gene ID" value="AA958_21490"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_21490"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4524"/>
    <dbReference type="OrthoDB" id="990666at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="2"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH84344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="322" mass="33162" checksum="1D5A80EF60A33A6E" modified="2015-07-22" version="1">MFDARHLRVLRAVAATGSFSAAARELGLTQPAVSQQMKALEQTAATPLLVRAGRELRLTEAGEALVRHAGGILAGLAAAEDEIAALAGLRAGRVRLVSFPSGSSTIVPGALAAMREAHPGTRISLVDAEPPRSVEMLREGECEIALAFHYPPAGETVPERGADAAAAGGGAAGEPVDGWDGLVVRPLLADRLLCLVPEGHPAAAAGRVELAELAAQPVIAGCPRCRRHLVELCERAGFAPRIDFATDDYPAVVGLVRAGLGTAVLPGLAVRAVPPRGVVTVPLTPEARREVVALTLPDLARVPAVAAMLDRLAAAAKDARDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAA3</accession>
    <name>A0A0F7NAA3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">LuxR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_21640</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017631.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_21640"/>
    <dbReference type="EnsemblBacteria" id="AKH84369">
        <property type="protein sequence ID" value="AKH84369"/>
        <property type="gene ID" value="AA958_21640"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_21640"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4557"/>
    <dbReference type="OrthoDB" id="930905at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="5">
        <location>
            <begin position="33"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="4">
        <location>
            <begin position="184"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH84369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="251" mass="26541" checksum="150B6110F889F181" modified="2015-07-22" version="1">MTDDAAGGTPAAGTPAAGIRASGAGPEGGRRVRVVLVDDHRMFRAGVQAEIGVTDETGVEVVGEAADVEQAVTVITATRPEVVLLDVHLPGGGGVEVLRRCSGLMGESPSGEAPVRFLALSVSDAAEDVIGVIRGGARGYVTKTITGTDLVDAIFRVSEGDAVFSPRLAGFVLDAFASTDAPPVDEDLDRLTQREREVLRLIARGYAYKEVAKQLYISVKTVESHVSAVLRKLQLSNRHELTRWATARRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAH6</accession>
    <name>A0A0F7NAH6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_28530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018769.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_28530"/>
    <dbReference type="EnsemblBacteria" id="AKH85535">
        <property type="protein sequence ID" value="AKH85535"/>
        <property type="gene ID" value="AA958_28530"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_28530"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6011"/>
    <dbReference type="OrthoDB" id="1864785at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046245">
        <property type="entry name" value="DUF6278"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19794">
        <property type="entry name" value="DUF6278"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH85535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="148" mass="16326" checksum="920A58FDF3438110" modified="2015-07-22" version="1">MNISFLDNWRRRHGSGREQRTSHPDTSVDQEGVAELLSECELLRVQAESAGVELDDTPRSLEELDQLLPRWRDDPEVTPWLGSDAGLYLGTVIVRTIAGAQWVIDSHDGAPVVRLSSGREMDVLEIGAEWAANGAPELSQMYAEVAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAJ8</accession>
    <name>A0A0F7NAJ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA polymerase sigma70</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_22350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017745.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_22350"/>
    <dbReference type="EnsemblBacteria" id="AKH84484">
        <property type="protein sequence ID" value="AKH84484"/>
        <property type="gene ID" value="AA958_22350"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_22350"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4706"/>
    <dbReference type="OrthoDB" id="1914729at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r4" evidence="1">
        <location>
            <begin position="94"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="159" mass="17937" checksum="3456267215EC3EC2" modified="2015-07-22" version="1">MRQRRSAQQRRRALEFETFCAGAAGRLLHAAQLLTAEPPDAAPQAERLLTQALARTYARWDRLRGEDPYETARQQLVARYAQTAWRYRRTSGGLLDRLSPQERLVLVLRMSEGVAEEQTAAALGLPPERVHQILMRASAAMLSRHTPAPGRTRREVATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAN5</accession>
    <name>A0A0F7NAN5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Myo-inositol-1-phosphate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_28880</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the myo-inositol 1-phosphate synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018828.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_28880"/>
    <dbReference type="EnsemblBacteria" id="AKH85595">
        <property type="protein sequence ID" value="AKH85595"/>
        <property type="gene ID" value="AA958_28880"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_28880"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6085"/>
    <dbReference type="OrthoDB" id="669352at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004512">
        <property type="term" value="F:inositol-3-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006021">
        <property type="term" value="P:inositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002587">
        <property type="entry name" value="Myo-inos-1-P_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013021">
        <property type="entry name" value="Myo-inos-1-P_Synthase_GAPDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11510">
        <property type="entry name" value="PTHR11510"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01658">
        <property type="entry name" value="Inos-1-P_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07994">
        <property type="entry name" value="NAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015578">
        <property type="entry name" value="Myoinos-ppht_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inos-1-P_synth" evidence="2">
        <location>
            <begin position="217"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH85595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="383" mass="39403" checksum="1C3BC80AB2334A59" modified="2015-07-22" version="1">MTVHRQDTAPQPANPATADTGVWLIGARGSVATTVISGCAALAAGLHPAAGMVTETAPFADCGLPAPARLVFGGHDVACTPLPKRADELAAGGVLPHGLPTAVAAELAAADEEIRNGGPEPGEPYDEEALIDSYAADITDFVRRRNLARAVVVNVASTEPVAAGDALPASSCYAAAALKAGCAYVNFTPSTGMHHPRLRELAAASGLPYAGRDGKTGQTLLRSVLAPMFLQRALEVRAWSGTNLLGGGDGANLAGDPAAAAAKNVGKERVLVDSLGGGVDGEVHIDDVPALGDWKTAWDHVVFDGFLGTRMVLQTIWQGCDSALAAPLVLDLVRIVARAHETGMSGPVPGLGFFFKDPDGGPPGLADQWRELLSVAERLRVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAQ4</accession>
    <name>A0A0F7NAQ4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Proline--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Prolyl-tRNA synthetase</fullName>
            <shortName evidence="8">ProRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">proS</name>
        <name evidence="10" type="ORF">AA958_26270</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys-tRNA(Pro) is not edited by ProRS.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro)</text>
            <dbReference type="Rhea" id="RHEA:14305"/>
            <dbReference type="Rhea" id="RHEA-COMP:9700"/>
            <dbReference type="Rhea" id="RHEA-COMP:9702"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78532"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.15"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2 8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">Consists of three domains: the N-terminal catalytic domain, the editing domain and the C-terminal anticodon-binding domain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.15" evidence="8"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018392.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_26270"/>
    <dbReference type="EnsemblBacteria" id="AKH85151">
        <property type="protein sequence ID" value="AKH85151"/>
        <property type="gene ID" value="AA958_26270"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_26270"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5530"/>
    <dbReference type="OrthoDB" id="665824at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004827">
        <property type="term" value="F:proline-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006433">
        <property type="term" value="P:prolyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00861">
        <property type="entry name" value="ProRS_anticodon_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00779">
        <property type="entry name" value="ProRS_core_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.960.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01569">
        <property type="entry name" value="Pro_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002316">
        <property type="entry name" value="Pro-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004500">
        <property type="entry name" value="Pro-tRNA-synth_IIa_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023717">
        <property type="entry name" value="Pro-tRNA-Synthase_IIa_type1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044140">
        <property type="entry name" value="ProRS_anticodon_short"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033730">
        <property type="entry name" value="ProRS_core_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036754">
        <property type="entry name" value="YbaK/aa-tRNA-synt-asso_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007214">
        <property type="entry name" value="YbaK/aa-tRNA-synth-assoc-dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04073">
        <property type="entry name" value="tRNA_edit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01046">
        <property type="entry name" value="TRNASYNTHPRO"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55826">
        <property type="entry name" value="SSF55826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00409">
        <property type="entry name" value="proS_fam_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="9">
        <location>
            <begin position="55"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AKH85151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="571" mass="61808" checksum="68B8AB5906ABBD8C" modified="2015-07-22" version="1">MSQHSHVQRMSRMMLKTLRDDPADAETASHKLLVRAGYVRRSSAGVWTWLPLGKRVLENVARVVREEMDAIGGQEVLLPALLPRELYERTGRAEEYGDLLFSLQDRKGVDYVLGPTHEELFAQVVKDQCSSYKDLPVILYQIQIKYRDEARPRSGVLRGREFHMKDSYSFDTSDEGLAAAYGLHREAYRRIFERLGFDYRIVSAVSGAMGGSASEEFLAPAAAGEDTYVQCPSCGFAANTEALTTTVAPSPADVHPPVEELDTPDTPTIETLAAHLDVPASATLKNLLVKVDGEITAVGVPGDREVDLGKLAEHLAPAQVEVVTAEDFAGRPDLVRGYVGPQGMAGKAFRYLADPRVAPGTSWVTGANKPDSHARNVVCGRDFEVDQYLDVVVVEPGDPCPRCGAGIELDRAIEIGHIFQLGRKYADAFELDVLGQNGKPVRVTMGSYGIGVSRAVAALAEQTHDELGLCWPREVAPADVHIVAAGKAKQTELALELAEKLGAAGVRVLVDDRASVSPGVKFTDAELIGVPQILVAGRRAGEGVVELKDRRTGEREELPVDEALARLTAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NB79</accession>
    <name>A0A0F7NB79_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Negative regulator of beta-lactamase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_27465</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018585.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_27465"/>
    <dbReference type="EnsemblBacteria" id="AKH85351">
        <property type="protein sequence ID" value="AKH85351"/>
        <property type="gene ID" value="AA958_27465"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_27465"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5787"/>
    <dbReference type="OrthoDB" id="1584918at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06583">
        <property type="entry name" value="PGRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.101.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036505">
        <property type="entry name" value="Amidase/PGRP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002502">
        <property type="entry name" value="Amidase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036366">
        <property type="entry name" value="PGBDSf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015510">
        <property type="entry name" value="PGRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006619">
        <property type="entry name" value="PGRP_domain_met/bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11022">
        <property type="entry name" value="PTHR11022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01510">
        <property type="entry name" value="Amidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00644">
        <property type="entry name" value="Ami_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00701">
        <property type="entry name" value="PGRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="SSF47090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55846">
        <property type="entry name" value="SSF55846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519381" evidence="2">
        <location>
            <begin position="36"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="PGRP" evidence="4">
        <location>
            <begin position="63"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetylmuramoyl-L-alanine amidase" evidence="3">
        <location>
            <begin position="75"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH85351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="372" mass="39105" checksum="DD15102D96C12F36" modified="2015-07-22" version="1">MAAHPGFDRRALLRGGLTASAAGALGLGAAGLAHAAPSSATLAAPGAATAPARGARALAAPEPRIYGTAEWGARPPATDIVILDHVPTYIAVHHTAEPGNSEDYSLEHAMEICRSIQNFHMDTQGWGDTGQQFTISRGGYCLEGRHESLGVVRGGTQHVQGANVGGRNSEVIGIENEGLYTDVDVPTALWDSLVAMVAWIAGQYGRPVENIQGHRDFNSTECPGDVLYARLPELRDAVAGVLGAPKPERTAVWPLLRPGDSGPVVRAAQHLLRARGFTGLPADGLFGPETKRAVAKLAEEGGVERHSCSAEFHKRNDETGYLGADIWPMITPRGRAGAGGEVGKAVEALLGRGRRAPAGRELDATVWKQLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBD0</accession>
    <name>A0A0F7NBD0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_27860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018650.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_27860"/>
    <dbReference type="EnsemblBacteria" id="AKH85416">
        <property type="protein sequence ID" value="AKH85416"/>
        <property type="gene ID" value="AA958_27860"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_27860"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5872"/>
    <dbReference type="OrthoDB" id="1583957at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026467">
        <property type="entry name" value="Ser/Gly_Cys_C_dom"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04222">
        <property type="entry name" value="near_uncomplex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519273" evidence="1">
        <location>
            <begin position="30"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="244" mass="25168" checksum="A60B822880473C57" modified="2015-07-22" version="1">MWVCFALVAWAAALLTCGRLVLVGSVAAAQPEPEPAQVRRARELTLYEAAFLAGGPRRVVDVTLVALARERRLLLAHTGWATVAAPEGRDPVERAVIAAAGSGGQNTIPAIRAAASAADALRDLDDGLAAAGLAVPAPIRSAVRAAVRQVRIAGVVVLGAGTAALALRPPEEEPIAGWFVLPLILVCGCLAIARLEVGEYTRWATPDGRGLLATLDEADSLLTGLAVHGPAALPDPEMRAALAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBK4</accession>
    <name>A0A0F7NBK4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Citrate (Pro-3S)-lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_28635</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018785.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_28635"/>
    <dbReference type="EnsemblBacteria" id="AKH85551">
        <property type="protein sequence ID" value="AKH85551"/>
        <property type="gene ID" value="AA958_28635"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_28635"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6032"/>
    <dbReference type="OrthoDB" id="1107373at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005000">
        <property type="entry name" value="Aldolase/citrate-lyase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011206">
        <property type="entry name" value="Citrate_lyase_beta/mcl1/mcl2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03328">
        <property type="entry name" value="HpcH_HpaI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015582">
        <property type="entry name" value="Cit_lyase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HpcH_HpaI" evidence="5">
        <location>
            <begin position="15"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 4">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR015582-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR015582-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH85551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="324" mass="35332" checksum="1FB731668E80D9B2" modified="2015-07-22" version="1">MSPAPTPSDRLRPRRSCLAVPGSSPRFLEKAQGLPVDQVFLDLEDACAPLAKPDARHTIVTFLNEGDWSGKTRVVRVNDWTTHWTYRDVITVVEGAGPNLDCLMLPKVQDAEQITALDLLLTQIEKTMGFEVGRIGIEAQIENARGLVNVDAIAAASPRLETIVFGPADFMASINMKSLVVGRQPPGYPADAYHYILMRILMAARSHDLQAIDGPYLQIRDVDGFREVAGRAAALGFDGKWVLHPGQVEAANEVFSPSQEDYDHAELILDAYEYHTSDEGGRKGSAMLGDEMIDEASRKMALVISGKGRAAGMTRTTAFTPPEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBQ8</accession>
    <name>A0A0F7NBQ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FAD-linked oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_31050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019143.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_31050"/>
    <dbReference type="EnsemblBacteria" id="AKH85915">
        <property type="protein sequence ID" value="AKH85915"/>
        <property type="gene ID" value="AA958_31050"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_31050"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6562"/>
    <dbReference type="OrthoDB" id="1188552at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-linked_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="SSF55103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="2">
        <location>
            <begin position="90"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="352"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH85915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="550" mass="57543" checksum="6C5481A589640D59" modified="2015-07-22" version="1">MTRSWWGWGTVEDAVRGTELAALLDRVRLLSSAEPVDHAPPPVAALGLPPPRVEPPAALAGLCSADPGDRAAHTHGKAFRDVVRNLHGDLRHPPDLVARPRHERDVADLLDWCTGAGVAAIPYGGGSSVVGGIEPRFTDGRPAVTLDLGRLDAVLEVDATSRAARIQAGVYGPRLAAQLRPHGLALRHFPQSFEFSTLGGWLATRAGGHYATLHTHIDDLVESLRVVAPVGTGESRRLPGSGAGPSPDRLFLGSEGALGVITEAWLRLQARPRWRARASVRFDDFAAAVAATRAVAQSGLHPANCRLLDPAEALVNAGVGSGGGVLVLGFESADHPVAGRLARALELCRDHGGVPDEPGESGVRDESGGAVQRGGRPGAGEPGEPGTGGGAGAAWRSAFLRMPYQRDALARHGMIAETFETACTWDAFGALHHAVTDAAHRAVRAVTGGAGVVTCRFTHVYPDGPAPYFGVIAPGRWGSTVAQWDDIKAAVSEAIAAHGGTITHHHAVGRDHRPWYDRQRPDPFAAALAAAKSALDPAGILNPGVLVPER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-12-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBV7</accession>
    <name>A0A0F7NBV7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_29405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018905.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH85676">
        <property type="protein sequence ID" value="AKH85676"/>
        <property type="gene ID" value="AA958_29405"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_29405"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6205"/>
    <dbReference type="OrthoDB" id="1800563at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="102" mass="11406" checksum="E615BFACFC7811AD" modified="2015-07-22" version="1">MMTSVDTDLIRVLADPRRLQIVTLLARETLCTTHLVEETGARQTNLSNHLRVLREAGVVETEPCGRFTYYKLRPDVIARLAGHFADLAESARTAGEKKRACP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBV9</accession>
    <name>A0A0F7NBV9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_29440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_29440"/>
    <dbReference type="EnsemblBacteria" id="AKH85681">
        <property type="protein sequence ID" value="AKH85681"/>
        <property type="gene ID" value="AA958_29440"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_29440"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6212"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase" evidence="1">
        <location>
            <begin position="16"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="372" mass="38748" checksum="F9BB79FC5FFEA9B0" modified="2015-07-22" version="1">MAAMTHQVQQRVQESLDRLVAQGRETGLQAAAYFQGELVADAAAGTADPAADRPLTPATLIHSFSTAKGVTATLAHAVAARHGLDYDTPVAEYWPDFAAHGKERITLRHVLTHTAGVPHLPADTVPAHMTDWDAMCARIAGLTPLWEPGTAMGYHGWTFGWILGEVVRRVTGLPLSAALRSYVSGPLGVEDSLFFGLPGSEHHRTATLVDGGWDAAIASLPDSAAIFTASPRPVAAGTELGNQKNYLSAHIPSAGTMTAAAVARMYAALLTDTDGIHLLPASTAEEAARPAVSAEDRMLGHPSPKTLGYFHGITWAGGSPQSFGTTGSGGSAAFADPTHGIAFALTKNRLTADSHAAHTVAAELYSALGRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBZ3</accession>
    <name>A0A0F7NBZ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">C4-dicarboxylate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AA958_25160</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018204.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_25160"/>
    <dbReference type="EnsemblBacteria" id="AKH84953">
        <property type="protein sequence ID" value="AKH84953"/>
        <property type="gene ID" value="AA958_25160"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_25160"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5302"/>
    <dbReference type="OrthoDB" id="781228at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046942">
        <property type="term" value="P:carboxylic acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001991">
        <property type="entry name" value="Na-dicarboxylate_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018107">
        <property type="entry name" value="Na-dicarboxylate_symporter_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036458">
        <property type="entry name" value="Na:dicarbo_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42865">
        <property type="entry name" value="PTHR42865"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00375">
        <property type="entry name" value="SDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118215">
        <property type="entry name" value="SSF118215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00713">
        <property type="entry name" value="NA_DICARBOXYL_SYMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0769">Symport</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="51"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="152"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="222"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="425"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH84953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="457" mass="47739" checksum="0ECF42D7FB0072DD" modified="2015-07-22" version="1">MAGRVKRDRTHYLYLAVIVAVLAGVLVGFAAPDAAVELKPIGEGFVNLIKMMISPIIFCTIVLGIGSVRKAAKVGAVGGLALGYFLVMSTAALAIGLVVGNIVQPGDGLHITDETRSVGADQAAAGDAESTTEFLLGIIPHTMVSAFTEGEVLQTLFVALLVGFALQAMGRVGEPVLTGIGHIQRLVFRVLAMIMWVAPVGAFGAIAAVVGETGVDALKSLAMIMIGFYATCALFVFVVLGLVLKFFTGINIFRLLKYLAREFLLIVSTSSSESALPRLIAKMEHLGVSKPVVGITVPTGYSFNLDGTAIYLTMASLFIAEAMGDPLTIGQQISLLVFMIVASKGAAGVTGAGLATLAGGLQSHRPELVDGVGLIVGIDRFMSEARALTNFAGNAVATVLIGTWTKEIDRDRVEQVLAGRVPFDEATLVDDHAPAPAEQPEEPADTPLKPGSQPVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NC14</accession>
    <name>A0A0F7NC14_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_31660</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019248.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86020">
        <property type="protein sequence ID" value="AKH86020"/>
        <property type="gene ID" value="AA958_31660"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_31660"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6686"/>
    <dbReference type="OrthoDB" id="2012009at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="86"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH86020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="255" mass="27546" checksum="B75673273CB0FBC8" modified="2015-07-22" version="1">MSRDDRDGGEPGGEPGGGPSGDPLAKRAAATVGPGLLYRLLLLAGLPALGLFLGWLVPRVADEVAGLEWAPMRGPFELVASFDDGWTAVAGPVVGLVLGLAGGLLVYVLAMRVTFEGDTVRIDKDGESRILARAEVAAAFLDKDRLVILDAASRQLLRRPTDLEPADLARGFTAHGYRWLHEDPYAGCYHRWVRDSAELSAAANAVLKAREHALGKKNATDAEELREEAQRLGYVLREEGTRQYWRPLRPGAAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NC53</accession>
    <name>A0A0F7NC53_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Beta-ACP synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_30255</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019019.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_30255"/>
    <dbReference type="EnsemblBacteria" id="AKH85791">
        <property type="protein sequence ID" value="AKH85791"/>
        <property type="gene ID" value="AA958_30255"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_30255"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6392"/>
    <dbReference type="OrthoDB" id="606297at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00834">
        <property type="entry name" value="KAS_I_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000794">
        <property type="entry name" value="Beta-ketoacyl_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712">
        <property type="entry name" value="PTHR11712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_KS" evidence="4">
        <location>
            <begin position="6"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH85791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="423" mass="45095" checksum="E5A3B866204688B3" modified="2015-07-22" version="1">MTQRRVVITGMEVIAPGGVGREEFWEEISEGRTATRGITFFDPAPFRSRVAAQIDFCGLDHGLSPQEVRRMDRAAQLAVVAARNAVADSGLDPAGLDLFRVGVTVGSAVGATMSLDSEYRVVSDGGRLDLVDHRYAVPHLYNHLVPSSFATEVAWAVGAQGPTAVVSTGCTSGIDAVGYGVDLLREGSVDVMVAGASDAPISPITMACFDAIKATTPRHDEPERASRPFDGTRNGFVLGEGSAFFVLEELESAKKRGARIYAEIAGYATRSNAYHMTGLRRDGAEMAEAIRLAIDEARLNPEDVDYINAHGSGTKQNDRHETEAFKKSLGDHAYRTPVSSIKSMVGHSLGAIGSIEIAASALAMRHDVVPPTANLHTPDPECDLDYVPLTAREHRVDTVLTVGSGFGGFQSAMVLASPERSPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCA1</accession>
    <name>A0A0F7NCA1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Signal peptidase I</fullName>
            <ecNumber evidence="3 5">3.4.21.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_25955</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.</text>
            <dbReference type="EC" id="3.4.21.89"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Membrane</location>
            <topology evidence="5">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the peptidase S26 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.89" evidence="3 5"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018335.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_25955"/>
    <dbReference type="EnsemblBacteria" id="AKH85094">
        <property type="protein sequence ID" value="AKH85094"/>
        <property type="gene ID" value="AA958_25955"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_25955"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5465"/>
    <dbReference type="OrthoDB" id="1741894at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000223">
        <property type="entry name" value="Pept_S26A_signal_pept_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019758">
        <property type="entry name" value="Pept_S26A_signal_pept_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43390">
        <property type="entry name" value="PTHR43390"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00727">
        <property type="entry name" value="LEADERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02227">
        <property type="entry name" value="sigpep_I_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00761">
        <property type="entry name" value="SPASE_I_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S26" evidence="7">
        <location>
            <begin position="37"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600223-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH85094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="286" mass="30407" checksum="5B1D1BB5AD3E624E" modified="2015-07-22" version="1">MSDGGDGSDGSSSRGEDADGGGAAAAGGKKQRSFWKELPILILVALVLALIIKTFLVQAFSIPSNSMQDTLQVGDRVLVDKLTPWFGAEPERGEVVVFHDPGGWLNEAPSSDSGPVLEGIQKGLSFIGLMPSAEEQDLIKRVIAVGGDTVECKGVGPVKVNGKALDETSYIFPGDTPCEDNDFGPVKVPEGKLWVMGDHRQDSLDSRYHEKSPDKGFVDEDLVVGRAIARAWPIDRWGTLPVPGTFDQPGLNAASGAAPAALGLAGAVPLVLWRRRRLIRKADLND</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCG5</accession>
    <name>A0A0F7NCG5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_30835</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019109.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_30835"/>
    <dbReference type="EnsemblBacteria" id="AKH85881">
        <property type="protein sequence ID" value="AKH85881"/>
        <property type="gene ID" value="AA958_30835"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_30835"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6517"/>
    <dbReference type="OrthoDB" id="758280at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH85881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="421" mass="45848" checksum="D33FFD5E97EF831C" modified="2015-07-22" version="1">MTAVTSARGASPRFDGSLSSSRERLSLAVALRDDWLGHAFSTLPADRPAAEAAVTGLYGLAGAPPPRFVWIPSPAAAPPALRDEQPAFARPRLRAADAPARWADWPVASRLASLLSALRTRLDRRVPRPWSVGHRPRPAWHQVAHTMTAEDALSDGYALRDVLWTAVHDPLSATLLDGPRPAIRTALLPAADAGPLGLTFHGQHDAHWIGHYDIHARLGLAAYRAADTRQLALWAALARAAGWWWPGDGVCVVAERPAEVHTEPLPGARHGELRLHHPGRPAVRYGDGAEVYALHGTAVPRWVVTEPTVARIHREPNVEVRRCAIERIGWDTYVDRAGLHLLAQAPDPGNPRSHLHLYHVPRRVWGTPGRVLLVVNGSVEPDGRRRRYGLSVPAGIDDPVAAAGWSYGLSGPQYARLARRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCK6</accession>
    <name>A0A0F7NCK6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ThuA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_32880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019447.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_32880"/>
    <dbReference type="EnsemblBacteria" id="AKH86220">
        <property type="protein sequence ID" value="AKH86220"/>
        <property type="gene ID" value="AA958_32880"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_32880"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6946"/>
    <dbReference type="OrthoDB" id="1452706at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029010">
        <property type="entry name" value="ThuA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06283">
        <property type="entry name" value="ThuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ThuA" evidence="1">
        <location>
            <begin position="21"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="285" mass="29906" checksum="E07A9346B08F0A43" modified="2015-07-22" version="1">MAAIGLVATSAVPAEAKSEPKVLIYTGTTGYRHAGSIDGGIGPIQKALDRAGISSVREDCDGLGGAVGNCDHPDANPRVFTPENLAQYDAIFLFNSSSQWLGGGRPGPLWDEEQRAAIRGFVNAGGGIAANHNAVDMGAGVTTWDWWDGAAGSAVGTLMTGHAASDLNNVATVRVEDRRHPSTRNLPKEFGFGDEHYNFARSVRGDAHVLATLDEETYEPGPNAMGEDHPISWCKQYDGGRIWVTGMGHFAESYSENGGNNNLVKHLTGGIGWAAGIGGGSKCTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCM5</accession>
    <name>A0A0F7NCM5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aldolase_II domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_31260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019179.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_31260"/>
    <dbReference type="EnsemblBacteria" id="AKH85951">
        <property type="protein sequence ID" value="AKH85951"/>
        <property type="gene ID" value="AA958_31260"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_31260"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6605"/>
    <dbReference type="OrthoDB" id="599627at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="SSF53639"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldolase_II" evidence="1">
        <location>
            <begin position="19"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="246" mass="27314" checksum="03838F85A19F9722" modified="2015-07-22" version="1">MQTSDALYSQDDSVANVLDNLARAHRILEMEGHGDMSMGHLSYRDPHGRGLWLKRGNLGMEEVRAGDYILIDFDGTVLEGQGLRHLEWPLHAEIMLARPDVNVVGHSHPFQATVLGAGRGRIEPVNNHGVWFAEHGVPRFDATSHIITTQELGRDLARVLGEADAVLQANHGASFTGRNVRDATLAGIFLEKAAAFQLALAGSGLPYDPPDAAESVEKNLRIYPERARENYWMYFNRKLDRLEAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCP9</accession>
    <name>A0A0F7NCP9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sugar-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_26825</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018486.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_26825"/>
    <dbReference type="EnsemblBacteria" id="AKH85249">
        <property type="protein sequence ID" value="AKH85249"/>
        <property type="gene ID" value="AA958_26825"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_26825"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5643"/>
    <dbReference type="OrthoDB" id="447734at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519304" evidence="2">
        <location>
            <begin position="31"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH85249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="464" mass="50055" checksum="BE3AC033E5974402" modified="2015-07-22" version="1">MRHTGFRRTSAALAVSAALALVAACGTSSSDEGGDDTADPADAAAPLDPETEVTLTIDCMPPAAEKAELKEWKEDVAAFKKEYPNVTIEGKQTDPCLEPPRFTAMLKAKSQPDAFYTYFTDLQQVLDNDGAADITAYVNEKTVPALADIDPQVLDVLKQDGKLYGLPTSNYTMGLLINRKLFEEAGLDPDDPPTSWDEVRTAAKAISGLGDGISGFGEYSAGNNGGWHFTASMYGLGGDIVSADGTRAAFNDDTGREYVENLHAMRWEDDSMGKTQLLKWGDLQKQMASGKLGMFLAAPDDITYMVQQLGGDYVDFGMGPIPGGEATLFGGNDYLIKKGSSPDQIKAAIAWLNFKFLTPGKGQFDWARTKADGLPVGLPQPDFWKGESKQQDDGLRAQHSTMPVENFQPFRDDPVPGRAEPPKAQEIYKVLDTVMSGVLTNEDADPAGLLDTAEDQVNQVLANQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDC1</accession>
    <name>A0A0F7NDC1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Bicyclomycin resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_27545</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial solute-binding protein SsuA/TauA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018597.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_27545"/>
    <dbReference type="EnsemblBacteria" id="AKH85363">
        <property type="protein sequence ID" value="AKH85363"/>
        <property type="gene ID" value="AA958_27545"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_27545"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5804"/>
    <dbReference type="OrthoDB" id="785019at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042626">
        <property type="term" value="F:ATPase-coupled transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010067">
        <property type="entry name" value="ABC_SsuA_sub-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015168">
        <property type="entry name" value="SsuA/THI5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09084">
        <property type="entry name" value="NMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01728">
        <property type="entry name" value="SsuA_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519331" evidence="4">
        <location>
            <begin position="26"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="PBPb" evidence="5">
        <location>
            <begin position="35"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH85363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="327" mass="34284" checksum="B5597E9FD38D2806" modified="2015-07-22" version="1">MRATRRTLALSLTVALISLPVAACSDDSGGGDGNTVRFGYINDYNGASLLAIAEKQGLWKEAGLDAEVSVFNNGPIQIQALGAGDLDFGYIGPGAMWLPASGKADVIAVNTLGYADRVIAQPGITSLAGLKGKKVGVPEGTSGDMALGLALQEEGMSIDDVEKVPMDPATIVSAFSSGQIDGAGLWYPMIDEIKAKVPGLEEVASTRDMQDSFFPTAFVAGTGVDPELSTKVVGVLQKANDWRFENPGESVAETAAMLKLDEKKVKADAANQELLPTKDLVAKTEDGTVGDWLNDLAEFFVGTGQLQEAPDPADYYLGDLYTKASAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDI3</accession>
    <name>A0A0F7NDI3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Indole-3-glycerol phosphate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_27920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018662.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_27920"/>
    <dbReference type="EnsemblBacteria" id="AKH85428">
        <property type="protein sequence ID" value="AKH85428"/>
        <property type="gene ID" value="AA958_27920"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_27920"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5885"/>
    <dbReference type="OrthoDB" id="1468357at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH85428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="155" mass="17135" checksum="F430B3DAA9881DCC" modified="2015-07-22" version="1">MFTTVLMIEKPLAPVDVEMVTTLHGQEPVSFVVLLQPRGDQGVLLRALDDVALGELEDAVRETDEPEGREALPTAKLALEHSLQALREKGAEAVGEIVDRHPLDLLQSVVEQTQADEVIVLTAPHLVEEFFHRDWASRARHKVGVPVLKLFAHEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDT0</accession>
    <name>A0A0F7NDT0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_28935</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH85604">
        <property type="protein sequence ID" value="AKH85604"/>
        <property type="gene ID" value="AA958_28935"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_28935"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH85604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="77" mass="8925" checksum="34D8816EF6767E2D" modified="2015-07-22" version="1">MHASLERVEGQPALVGNHQFAVQDQFLPQRSRSRGDVRERFAEVRPGRDWTKMWPLRAKMMTRNPSREFFAAASTPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NE19</accession>
    <name>A0A0F7NE19_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_01500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_01500"/>
    <dbReference type="EnsemblBacteria" id="AKH86486">
        <property type="protein sequence ID" value="AKH86486"/>
        <property type="gene ID" value="AA958_01500"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_01500"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.329"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="247" mass="25854" checksum="2AADBCCE252484EB" modified="2015-07-22" version="1">MLSSETLLVLALSLGASAVSALISFIGSVTRSGGLKEQSANLNSSAAPGRPWLDLAWQLFGITTALVPVALVAYLLVRERAGGLGAVGLDGRRPGFDLGWGAAVAAVVGGTGLAFYLGARAAGFNLTVVPESLPDVWWKIPVLILSAVQNSVVEEVIVVGYLLRRLDQLGWTPKASLAASSLLRGTYHLYQGIGGFIGNAVMGVLFVLLYRRWGRVGPLVAAHAFIDIVAFVGYALLAGKVGWLPTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NE48</accession>
    <name>A0A0F7NE48_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carb-bd_dom_fam9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_25350</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018238.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_25350"/>
    <dbReference type="EnsemblBacteria" id="AKH84987">
        <property type="protein sequence ID" value="AKH84987"/>
        <property type="gene ID" value="AA958_25350"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_25350"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5342"/>
    <dbReference type="OrthoDB" id="469319at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016137">
        <property type="term" value="P:glycoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010502">
        <property type="entry name" value="Carb-bd_dom_fam9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003737">
        <property type="entry name" value="GlcNAc_PI_deacetylase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024078">
        <property type="entry name" value="LmbE-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993">
        <property type="entry name" value="PTHR12993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06452">
        <property type="entry name" value="CBM9_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02585">
        <property type="entry name" value="PIG-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102588">
        <property type="entry name" value="SSF102588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Carb-bd_dom_fam9" evidence="3">
        <location>
            <begin position="399"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="574"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH84987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="626" mass="67527" checksum="05BE47F666B81EDA" modified="2015-07-22" version="1">MTNSAQGDRTEPVRAQDGDGSGPSRRVVSAALVSGIVGTALGATAPSAWADEWSVPRPRRAPGGRRDRAHNDVLFVGAHPDDEAGNLSTFGQWREQHGLSTGVLTVTRGEGGGNAVGPEEGPPLGLIREDEEREAVGFAGIDNVYYLDKPDFWYTLSGPLTAAIWDADDTLERIVRLIRATTPDTVVTMDPRPFNQHGGHQLSARLAIEAFFLAGDPRAFRSQITQEGYRPHRARLLLAQNYGFGSLLGPDAPKQRRTDRASGLPVFGVFSGVRSEEHGTSWAQVERDAARKYVTQGWAARPAQMPTDPEQLGSDWFTVLAANGKAVKSKVRPQNELRPVYAEFRDWTERVGLPWLANDAQPDYPEAPATTIPEVATAPVLDGVERPGEYPGPELPLVHWQGEKTGAEDVSATAKLSRHGDDLYVFVKVTDDRRGTALEESDAKRHWRTDAVEITLDPRGTADDTSTTFKTGIFPYTANGGGAAAERDGDNRQGPAATTAPGMRVVSLVSDPYQGYTIEAKIALADLPAAADPEKFTLNVLVYDSDTEDKTGQTRLAWSPFGSAQADPYVWGTATLEGYTPPADRPTEPAEPEIPKDAARSEDSPASVAQSQRTGVPLAVGPRPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NE96</accession>
    <name>A0A0F7NE96_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glucose-6-phosphate isomerase</fullName>
            <shortName evidence="7">GPI</shortName>
            <ecNumber evidence="7">5.3.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Phosphoglucose isomerase</fullName>
            <shortName evidence="7">PGI</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Phosphohexose isomerase</fullName>
            <shortName evidence="7">PHI</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">pgi</name>
        <name evidence="9" type="ORF">AA958_05665</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7 8">
            <text>alpha-D-glucose 6-phosphate = beta-D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11816"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="EC" id="5.3.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 7 8">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 8">Belongs to the GPI family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.9" evidence="7"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019806.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_05665"/>
    <dbReference type="EnsemblBacteria" id="AKH86566">
        <property type="protein sequence ID" value="AKH86566"/>
        <property type="gene ID" value="AA958_05665"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_05665"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1186"/>
    <dbReference type="OrthoDB" id="417261at2"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00181"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004347">
        <property type="term" value="F:glucose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05015">
        <property type="entry name" value="SIS_PGI_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05016">
        <property type="entry name" value="SIS_PGI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00473">
        <property type="entry name" value="G6P_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001672">
        <property type="entry name" value="G6P_Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023096">
        <property type="entry name" value="G6P_Isomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018189">
        <property type="entry name" value="Phosphoglucose_isomerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035476">
        <property type="entry name" value="SIS_PGI_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035482">
        <property type="entry name" value="SIS_PGI_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11469">
        <property type="entry name" value="PTHR11469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00342">
        <property type="entry name" value="PGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00662">
        <property type="entry name" value="G6PISOMERASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00174">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51463">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7 8" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="4 7 8" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5 7 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="360"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="391"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH86566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="550" mass="60203" checksum="3A34DAA80C6CF929" modified="2015-07-22" version="1">MADTTSRTRLDQTPEWHALAKHREEFGATHLRELFAADPERGRRYTLRVGDLYLDYSKHLVTDETLRLLRELAAATGVAELRDAMFRGEKINITEDRAVLHTALRAPSAETVEVDGVDVVPGVHHVLTRMTTFADRVRSGDWRGHTGKPVRAVVNVGIGGSDLGPAMAYEALRAYTQRDLTVRFVSNVDGADLHEAVRDLDPETTLFVIASKTFTTIETITNATAAKRWLLAGLGAGDEAVAKHFVALSTNAAKVAEFGIDTDNMFEFWDWVGGRYSYDSAIGLSLMVAIGPVAFREMLAGFRLVDEHFRTAPPEENAPLLMGLLGIWYGDFFDAQSHAVLPYSHYLSKFTAYLQQLDMESNGKATDRRGERVGWQTGPVVWGTPGTNGQHAYYQLLHQGTKMIPADLIGFARPVPGLGELTGQHDLLMANLFAQGQALAFGKTAAEVAAEGVPEAQVPHRTFPGNHPTTTILADGLTPSVLGQLVALYEHKVFVQGAVWDIDSFDQWGVELGKVLAKRLEPVLTDGTEVDGLDGSTLALVDAYRALRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NEV9</accession>
    <name>A0A0F7NEV9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_23045</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_23045"/>
    <dbReference type="EnsemblBacteria" id="AKH86980">
        <property type="protein sequence ID" value="AKH86980"/>
        <property type="gene ID" value="AA958_23045"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_23045"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4857"/>
    <dbReference type="OrthoDB" id="1181903at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="24"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="63"/>
            <end position="70"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH86980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="282" mass="29806" checksum="FAAB1F67B9D8BDFA" modified="2015-07-22" version="1">MFGRKDRSGTAAGPVAGGAPHEALRLVKVTKVYGTGGAEEAAVTALDGVTLSLPAGSFTAVMGPSGSGKSTLLQCAAGLDRPDSGVVMVDGAEMTGGSETELTKFRRERIGFVFQQYNLLPTLNVAQNTVLPLKLAGRRVDRARVREVLARVGLADRMRHRPDQLSGGQRQRVAIARALVAAPSVVFADEPTGALDTRSARDVLGLLQETVRVDRRTVVMVTHDPVAASYADSVLFLADGRLVGQMNAPTADAVAERMTHLGDMYEAGARQHDPRHSAPMGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NEW7</accession>
    <name>A0A0F7NEW7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FAD-linked oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_26920</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; L-ascorbate biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018504.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_26920"/>
    <dbReference type="EnsemblBacteria" id="AKH85267">
        <property type="protein sequence ID" value="AKH85267"/>
        <property type="gene ID" value="AA958_26920"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_26920"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5662"/>
    <dbReference type="OrthoDB" id="482388at2"/>
    <dbReference type="UniPathway" id="UPA00132"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003885">
        <property type="term" value="F:D-arabinono-1,4-lactone oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019853">
        <property type="term" value="P:L-ascorbic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007173">
        <property type="entry name" value="ALO_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010031">
        <property type="entry name" value="FAD_lactone_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006093">
        <property type="entry name" value="Oxy_OxRdtase_FAD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43762">
        <property type="entry name" value="PTHR43762"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04030">
        <property type="entry name" value="ALO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000136">
        <property type="entry name" value="LGO_GLO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00862">
        <property type="entry name" value="OX2_COVAL_FAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0060">Ascorbate biosynthesis</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="5">
        <location>
            <begin position="20"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH85267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="443" mass="47046" checksum="5A90B671042BD495" modified="2015-07-22" version="1">MHQVRGTSAAGAWRNWAGTVAARPARTVSPATTAEVADAVRTAAEEGLKVKAVGTGHSFTAAAATGGLMIRPERLVGIHEIDRGAGTVTVAAGTPLHQLNHALAAAGLSLTNMGDIMAQTVSGATATGTHGTGRSSASLAAQITALELVTADGRARTYTAADTGEDAAVFAAARLGVGALGVVTSLTFAVEPVFLLTAREEPMALTDVLASFEELAGENEHFEFYWFPHTGRCNTKRNNRSEGPAEPLGRIGGWIDDELLSNGVFRAACAVGRAVPAAIPGIAAVSSRALSARTYTDIPYKVFTSPRRVRFVEMEYALPRAAAVTAIRELKTMVDRSRLRISFPVEVRVAPADDIPLSTASGRDTAYVAVHLYRGTPHQAYFTAVERIMTAHGGRPHWGKLHSRDAEYLAGVYPRFGEFTAVRDRLDPGRVFGNDYLRRVLGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NEZ8</accession>
    <name>A0A0F7NEZ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_25280</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020406.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_25280"/>
    <dbReference type="EnsemblBacteria" id="AKH87030">
        <property type="protein sequence ID" value="AKH87030"/>
        <property type="gene ID" value="AA958_25280"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_25280"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5328"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GAF" evidence="2">
        <location>
            <begin position="42"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="GAF" evidence="2">
        <location>
            <begin position="210"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="3">
        <location>
            <begin position="470"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="556"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH87030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="593" mass="63284" checksum="5BC87989F2981460" modified="2015-07-22" version="1">MPRLQLDQLLDELQLRIDEVRGTRDRVHSLLEAVLTVGRELDLSQVLRRIVEAAVVLVDAEYGALGVIEHGERLAQFVPVGISVEEYEEIGPLPQGHGVLGELIRHPEALRIQELQDHPSSYGLPPNHPPMHSFLGVPIRVRDEVFGNLYLTEKRGAKEFDGEDEAVLSTLAVAAGVAIENARLYEEARRRQRWIEASGEVTNTLLSGAQEEEVLGLMLDRARSILKADLGTVALPAEGADELRIILAQGTAADALAGRTLPMKGTLSGAAFTRVELAISDDVTKDPRVRDGGLPENGIGPAVAVPLGTSDGLRGVLLVGREAGGERFGPEETDALVGFAGQAAVAMELAQRRRDAEQLALFEDRDRIARDLHDLAIQRLFATGMTLQSAVRFVTHEEGTERLLRAVDDLDETIKIIRTTIFGLRRHEHGTAAQGLRLRVLSQVKDSVATLGFTPVLRTEGLLDTDVPAPVADHLVAVLGEALSNAARHAGASSVEITVIAGQGLVALTVTDNGRGLPDGGRRSGLANIAERARQLGGELMLDPPAGGGTRLVWRVPLDHRAAQERGGPGEQADGPEGGGGGTDGSGQDPGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NF02</accession>
    <name>A0A0F7NF02_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptide deformylase</fullName>
            <shortName evidence="2">PDF</shortName>
            <ecNumber evidence="2">3.5.1.88</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Polypeptide deformylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">def</name>
        <name evidence="3" type="ORF">AA958_17290</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>H2O + N-terminal N-formyl-L-methionyl-[peptide] = formate + N-terminal L-methionyl-[peptide]</text>
            <dbReference type="Rhea" id="RHEA:24420"/>
            <dbReference type="Rhea" id="RHEA-COMP:10639"/>
            <dbReference type="Rhea" id="RHEA-COMP:10640"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:49298"/>
            <dbReference type="ChEBI" id="CHEBI:64731"/>
            <dbReference type="EC" id="3.5.1.88"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="2">Binds 1 Fe(2+) ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the polypeptide deformylase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.88" evidence="2"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_17290"/>
    <dbReference type="EnsemblBacteria" id="AKH86841">
        <property type="protein sequence ID" value="AKH86841"/>
        <property type="gene ID" value="AA958_17290"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_17290"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3636"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042586">
        <property type="term" value="F:peptide deformylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.45.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00163">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023635">
        <property type="entry name" value="Peptide_deformylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036821">
        <property type="entry name" value="Peptide_deformylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10458">
        <property type="entry name" value="PTHR10458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01327">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004749">
        <property type="entry name" value="Pep_def"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01576">
        <property type="entry name" value="PDEFORMYLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56420">
        <property type="entry name" value="SSF56420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="2">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH86841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="160" mass="17922" checksum="DC245D9143DD1248" modified="2015-07-22" version="1">MPAADVAEPGSARTAETAADLADTLADWVARTGYGRGIAAPQIGVDSRVIHLHLDRPWTLINPRITGRSTETWEPWDACLSFSLQFFCRVSRATWVDVEYVSADGERHGLRADGDLCELLQHEIDHLDGIMAVDRMISPSTLCMRSEFEKRHRDESPYPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NF04</accession>
    <name>A0A0F7NF04_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AA958_31815</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019272.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86044">
        <property type="protein sequence ID" value="AKH86044"/>
        <property type="gene ID" value="AA958_31815"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_31815"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6719"/>
    <dbReference type="OrthoDB" id="643917at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="61"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="29"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="343"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="377"/>
            <end position="384"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AKH86044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="588" mass="61822" checksum="39DAE58D9FEDBF26" modified="2015-07-22" version="1">MAVDEAPEAGTPPWRMLLAYARPHRWALLAGALLSLATGATGLALPLVARSLIDDLSHDRSIAGALIVMSVLVVANAGVGALGSYVLRRTAESVVLTARRRLSSYLLRLRIAAVDRTEPGDLMARVTSDSTLLREVTTDTLVGLGTGGLTAVATLVLMGVVDPVLLAVTAGVIFAAGTVIGVIVPRINRAAKRAAESVGLMGAALERVLGALRTIKASGAEHREERAVHEAAEESWRQSVRAAKWSALAGNTAGLSMQVAFITVLAVGGARVATGAIDVGTLVAFLLYVFYLMSPIQQLVSAVAQYQTGAAALERIREAQLLPAEPAAEPAPLPEPGAEPAALAFEDVRFRYADDLPYVHHGVSFAIPPRGMTAFVGPSGAGKTTVFSLIERFYEPTAGRILLDGHDVTRWEIPALRAAIGYVEQDAPVLSGSLGDNLLLGNAAAGEDDVREVLKTTRLEELVARLPQGLDTLVGHRGTKLSGGERQRVAIARALLRRPRLLLLDEATSQLDAVNEAALRDTVAEVSRDTTVLVVAHRLSTVTSADRIVVMDRGEVRAVGTHAELVAGDPLYAELATTQFLAAAAGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NF28</accession>
    <name>A0A0F7NF28_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PHB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_27765</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_27765"/>
    <dbReference type="EnsemblBacteria" id="AKH87070">
        <property type="protein sequence ID" value="AKH87070"/>
        <property type="gene ID" value="AA958_27765"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_27765"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5852"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="SSF117892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PHB" evidence="2">
        <location>
            <begin position="221"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="543"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH87070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="573" mass="62774" checksum="81E302210302E955" modified="2015-07-22" version="1">MVGVVRRRIGGNPSDPRFKRVVADNSRGIQARCLTPGVRHWLMPGVYSVDLAPRVSIPPGMIGLVTALDGASRPAGRLLSRRVECDNFQNGVAFLLGEGEQGRQLATLPGDASYYINPELFRVDFVPRTHVPDGTVGLVRAKVGQLRLPDQPFGRYVECDVFQDGDAFLLGGGEQGRQLAVLGGGASYDIHPDLFEVLTTENIGPGRQDGLTPGHLRYVNIPVGYVGVVVTLHGIEPPPEDDVIGPVVPGHSNYRLPWKFLDGHGWRGVQQETLRQGGVYALNPWFARIVLIPTRLLTLEWKDKMPTEADNYDAELEQLIINIQGFLLKVNVTQTLQIPASAAPRLVSQFGGEVSRDGLGGLVIDPRPVQRFVERVLGGTVESYLTQVAASSTVEEYLTQQDDIRAELAARVRQNVAEWGITVSDTLVGLSVAQDSELDRIRRLPMTEAHRRRTLEEEVKSAQIHAQIRRIEIAVEREERGLAVAELEALANLLGPEVASVQALLAEVKDMRVPDVISGDAAMMGQFMPWQRIQDVITGLRREQSGDPVLETVSQKDELEAGDGPADDLRPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NF60</accession>
    <name>A0A0F7NF60_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Gramicidin dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_29320</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioesterase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020506.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_29320"/>
    <dbReference type="EnsemblBacteria" id="AKH87110">
        <property type="protein sequence ID" value="AKH87110"/>
        <property type="gene ID" value="AA958_29320"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_29320"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6183"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012223">
        <property type="entry name" value="TEII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11487">
        <property type="entry name" value="PTHR11487"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="2">
        <location>
            <begin position="18"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH87110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="252" mass="27247" checksum="7C59653F49EB2305" modified="2015-07-22" version="1">MRNPWFGRNEPGQEAAVRLFCLPYAGGSAAAYRDWHDLAPPGIQVCPLELPGRGGRILEPPMTRLPQLAGALADALSPHLDRPFAVFGHSMGGLLAFELTRTLRRRRRPLPAHLFVSATAAPDVPRTRPPVHQASDADVVGELRTLGGTPRELLEDEELMRLMLPTIRADFSVLENYRYGPEPPLPVPLTVLGGADDPLVPVPDLEGWRRQTDGDAGLRLLQGGHFFLHPADGVMAVIAEAVGIPASATPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NF97</accession>
    <name>A0A0F7NF97_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">S-adenosyl methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_30650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020576.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_30650"/>
    <dbReference type="EnsemblBacteria" id="AKH87150">
        <property type="protein sequence ID" value="AKH87150"/>
        <property type="gene ID" value="AA958_30650"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_30650"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6478"/>
    <dbReference type="OrthoDB" id="1139523at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006764">
        <property type="entry name" value="SAM_dep_MeTrfase_SAV2177_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04672">
        <property type="entry name" value="Methyltransf_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017393">
        <property type="entry name" value="MTase_SAV2177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH87150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="270" mass="29013" checksum="FDFDB363033636E1" modified="2015-07-22" version="1">MSEETFSDGTQRVVIDTSVPHSARIFNYWIGGKDNYEPDRAAGARFQQVFPEIVDLARSGRQFLRRVVGHLAGEAGVRQFLDIGTGLPTADNTHEVAQRAAPDSRIVYVDNDKLVLAHARGLLTSTPEGATAYIDADVEDPEAILAGAARTLDLDRPVAVILMGILAHVDGYEQARSVVRRLMDPLPSGSYLAIRDGVEGNEKYSRAIAGYNASGAVPYHLRSAAQIAGYLDGLEPVEPGVVSCPLWRPEPVEVGSPVEMAVLGGVGRKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFF8</accession>
    <name>A0A0F7NFF8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AA958_32750</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019426.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_32750"/>
    <dbReference type="EnsemblBacteria" id="AKH86199">
        <property type="protein sequence ID" value="AKH86199"/>
        <property type="gene ID" value="AA958_32750"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_32750"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6919"/>
    <dbReference type="OrthoDB" id="643917at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="220"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="261"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="357"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="222"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="557"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="590"/>
            <end position="597"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AKH86199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="800" mass="84711" checksum="28A8CDB9642CDE1E" modified="2015-07-22" version="1">MTSTLAAGPRANGVAVVAPRARSGNGGRAVPRPRSILPGRQRWEVDLFRGRPGLARVAEASLRQARGIEDVRVNPVTGRVLLRHDHTLAPRDAARLLYVAVDRVLTALHTPAANALGDGPAAPPAYLPEARPSRGAAGTARRLPRILGLGCAAAAAVTGGPLLLRFLRRPLLTLGAAAVATAVVVRRAWRRTDRAREGPDGPGPRRHAVRRIVGRHRRKFGVAALLSGLSTLAEMALFALTPSIVLLVARGGSATLTRYGIAGISAQLGTLAAAGALACAVMAGTGYAAGVAWRGVAQDVEDDWRTRTYAHVQSVAPADLENERVSRVNAVLSEDIGRLGTFVGTNMHDVVQMCAGLALLVPMFLLLAPQLAWIAFAPIPLVAWLSFRFHERAVADTAACGERRAQLNSRVTENLHAHTTIKSATTEAHEIARIGELNGRCSEANRSAGRSAALPPQILRLAGGSALVGTVLLGGRAVLRGELAIAAFGPLIELPGIAMLKLSRVGSASDHYQRTLAALERIERLHELPVEPQGGAGTGDPAAAGRELPLRSLRGRIELRKVTFAYPGRAPVLRDTSLIIPPGRTTALVGTTGAGKTTIAKLLMRFRHPERGQVLLDGTDVRTLALPDLRRAIGYVAQEPFLFDATIAENIRYGTFEATEAQLVAAARTAGAHAFIDGLPDGYDTRVGERGAALSGGQRQRIALARTVLRDPPVVILDEATSAVDNETEATIQRALQVFGADRTMLVIAHRLSTVQCADRIYVMGSGGTVAERGTHDELVALGGVYSSLWKLRSGRPALM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFM1</accession>
    <name>A0A0F7NFM1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">LuxR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_28340</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018736.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_28340"/>
    <dbReference type="EnsemblBacteria" id="AKH85502">
        <property type="protein sequence ID" value="AKH85502"/>
        <property type="gene ID" value="AA958_28340"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_28340"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5973"/>
    <dbReference type="OrthoDB" id="1687028at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="5">
        <location>
            <begin position="31"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="4">
        <location>
            <begin position="180"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH85502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="247" mass="25979" checksum="EB04C2F6CC769E79" modified="2015-07-22" version="1">MPDQTPDPADPADPADPADPADPADPTARIAVLLVDDDPLVRAGLRLMLGGAGDIDVVGEAADGGEVPALVAAHAPDVVLMDIRMPRLDGLAATEALRRRAEPPEVLVLTTFHTDEHVLRALRGGAAGFVLKDTPPREIVAAVRKVAAGEPALSPAVLQQLIAQVSGAGAEERARAGEHARRRLAALGEREREVAVAVGRGRSNAEIAAELYMSVPTVKTHVSRILTKLDLNNRVQIALLVHDARES</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NGD2</accession>
    <name>A0A0F7NGD2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_30355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019035.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_30355"/>
    <dbReference type="EnsemblBacteria" id="AKH85807">
        <property type="protein sequence ID" value="AKH85807"/>
        <property type="gene ID" value="AA958_30355"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_30355"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6413"/>
    <dbReference type="OrthoDB" id="1664470at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="652" mass="69936" checksum="CE01F3196075517A" modified="2015-07-22" version="1">MTAPAPRDESRETRRAANARKRISRRPSRLGSPAGATPKPDREREPGAGFTGLLERAWARARQAGGPRAAVGVLLTLDGHVPAGVQLRALGTAEEAAFKALWGLTWRTGEAAADTAADGAADRDAEDEPVFTGELALARSGRVAVRAPSQPPLRQQDLVGGSLRVPWSARAVRAYRRELAAATARRADEVAHCRAWLAEQGEAGRDELLDLATEAALRTAPFVLYQEEKQYTNFRDQNNITGKTLFPGHPDCALSSLRGLPLDLWSDHDVQLLVCLVLLIRSAGPGRVEEANGTQLSLDHVAAMLERVRRGYAAAPGGPSLPHAAAPDIAALDTLATTLGTVRKAFPGRVQLYREIHGALMHKIERVAAPPAARAHRYEQDICARLSERLPLAGGTFDALADAAAAAPGWLARPHGAFGSGLESLVYETVAASADVFRTDFAMSRGMRSLPTLVARLRAESWAEICGWDITKYFCCVVPAPEARRHFGDSATAMADAAWAMSSRMQYNSWHFIAGNLPRTEEVLARDHFVPPTIPDVAFFSDQHHHGHVTNKVRFSIRSPQAVEVAGRRFNGFVDLRLLRCDGTPFDEQDLLAAHRVSGLVGRVTGLAAELAAAGEPVEVTAFDAGWHRAAIAGAPAAARTAGAAGRATGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NGZ9</accession>
    <name>A0A0F7NGZ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase M15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_06210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_06210"/>
    <dbReference type="EnsemblBacteria" id="AKH86573">
        <property type="protein sequence ID" value="AKH86573"/>
        <property type="gene ID" value="AA958_06210"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_06210"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1299"/>
    <dbReference type="OrthoDB" id="1593541at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009045">
        <property type="entry name" value="Hedgehog_sig/DD-Pept_Zn-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003709">
        <property type="entry name" value="Pept_M15B"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02557">
        <property type="entry name" value="VanY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55166">
        <property type="entry name" value="SSF55166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VanY" evidence="2">
        <location>
            <begin position="87"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH86573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="213" mass="22436" checksum="FE5FD66462EA4B06" modified="2015-07-22" version="1">MRTLLGVGMIALVVAIVAPLGYRSMQTPSGSTASPAPVTPSSAEAPEPAEPAESPQRKRSGPVGEADGVVPEGTTVFDDGVPAVAGLDAALRTALREAATDAAAYGIDIRVNSGWRSPAYQDRLLRDAIGKYGSEEEAARWVATAETSPHVSGDAVDLGESDATMWLAEHGAAYGLCPVYRNEPWHYELRTEAIGGRCPPMYADPTQDPRMQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NHE0</accession>
    <name>A0A0F7NHE0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_32445</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <location>
            <begin position="44"/>
            <end position="61"/>
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        <location>
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            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="126"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH86152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="172" mass="18797" checksum="8C2F644FFBBA5E09" modified="2015-07-22" version="1">MSGEILFTALVLAVGLERVAELVVSQRNAAWSIARGGLESGRGHYPFMVVLHTGLLAGALVEVWVRRPDTAPVLAWAMLLLVAASQALRWWCIATLGRQWNTRVIVVPGSPRVTGGPYRWFSHPNYVAVVVEGLALPLVHSAWITAVVFTMLNGFLLTTRMRVEDAALARLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NIA8</accession>
    <name>A0A0F7NIA8_9ACTN</name>
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        <submittedName>
            <fullName evidence="2">Molecular chaperone GroES</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
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        <lineage>
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            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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    </dbReference>
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    <dbReference type="OrthoDB" id="884088at2"/>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="13"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="320" mass="33530" checksum="568D07908EEAAB35" modified="2015-07-22" version="1">MFAAYAARIDRDEPLNGLELGERPAPQAPPGWAVVDVRAASLNHHDLWSLRGVGLGEDALPMILGCDAAGVDADGNEVVLHSVIGQTGHGVGPNEPRSLLTERYQGTFAEQVAVPAWNVLPKPKELSFEEAACLPTAWLTAYRMLFTNAGVRPGDSVLVQGAGGGVATAAIVLGAAAGLRMYATSRDEAKRKRAEDLGAEAAVAPGTRLPHRVDAVLETVGAATWSHSVKSLRPGGTLVISGATSGPNPAAGELQRIFFLELKVVGSTMGSKEELAGLLNFCASKGVRPVIDTVLPLDRAREGFEKMATGDLFGKVVLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NIA9</accession>
    <name>A0A0F7NIA9_9ACTN</name>
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    <organism evidence="3 4">
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        <lineage>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
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    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_31725"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6699"/>
    <dbReference type="OrthoDB" id="1046291at2"/>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="25"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH87179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="295" mass="30910" checksum="B1DCA4FA2CADC244" modified="2015-07-22" version="1">MTYVAAELADQPACWRRATELAGVHGPLLPQPGERVAAVGCGTSYFMAQAYATLREEAGHGETDAFPASGFPAGRRYDRVLALTRSGTTTEVLRLLGTLSGSVRTAAIVADGATPVAEAADDTVVLDFADERSVVQTRFATTALTLLRAHLGVQPATAVEDAELALVEPLPQGLLAARQFTFLGAGWTVGLANEAALKMREAALAWTESYPAMEYRHGPISITTSGTATWMIGDAPAGLEDEVHATGALWITGGLDPLAELVRAQRLAVALAGARGLDPDEPRHLTRSVILSPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NIE9</accession>
    <name>A0A0F7NIE9_9ACTN</name>
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        <submittedName>
            <fullName evidence="2">Glyoxalase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_04360</name>
    </gene>
    <organism evidence="2 3">
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        <lineage>
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            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019775.1">
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_04360"/>
    <dbReference type="EnsemblBacteria" id="AKH86542">
        <property type="protein sequence ID" value="AKH86542"/>
        <property type="gene ID" value="AA958_04360"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_04360"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.916"/>
    <dbReference type="OrthoDB" id="1984437at2"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="5"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="124" mass="13736" checksum="EB5674887CE9706A" modified="2015-07-22" version="1">MPVATFCLVAVDCPDPLRLARFYRGLLGGEVSSRGDDWYDLLAPDGTRLAFQRAPGLRPPNWPRADDNSQQLHLDLRVTDIEAAERHALELGARPLDTDDDGGRRDFRVYADPAGHPFCFVSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NIG4</accession>
    <name>A0A0F7NIG4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019793.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_05210"/>
    <dbReference type="EnsemblBacteria" id="AKH86557">
        <property type="protein sequence ID" value="AKH86557"/>
        <property type="gene ID" value="AA958_05210"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_05210"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1094"/>
    <dbReference type="OrthoDB" id="1756326at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH86557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="236" mass="24640" checksum="38BDC6E23585927C" modified="2015-07-22" version="1">MLRVVNRILLAVTGLLVAGAGIVVLFAGLDLPRPGFAPYAGGSDDVLLSRATRLRWRDDGWWWPTVIGGLSLLLLCSGWWLVAQLRRARLGEVVVDTGGALAPAAPGASGTERAQEGDWASATDPDPDGTESGGPATLTLPAAPQALLRGSALEEVLAEEAGALEGVERARVTLTGRRTAPRASFGVLLGPGAHPAAAVDHIEERALAPARASVGLARLPAEIRFRPAKHRPERVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NIS5</accession>
    <name>A0A0F7NIS5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phenylacetate-coenzyme A ligase</fullName>
            <ecNumber evidence="1">6.2.1.30</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Phenylacetyl-CoA ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_12240</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-phenylacetate + ATP + CoA = AMP + diphosphate + phenylacetyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:20956"/>
            <dbReference type="ChEBI" id="CHEBI:18401"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57390"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.30"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Aromatic compound metabolism; phenylacetate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the phenylacetyl-CoA ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.30" evidence="1"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_12240"/>
    <dbReference type="EnsemblBacteria" id="AKH86707">
        <property type="protein sequence ID" value="AKH86707"/>
        <property type="gene ID" value="AA958_12240"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_12240"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2574"/>
    <dbReference type="OrthoDB" id="839891at2"/>
    <dbReference type="UniPathway" id="UPA00930"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047475">
        <property type="term" value="F:phenylacetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010124">
        <property type="term" value="P:phenylacetate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05913">
        <property type="entry name" value="PaaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028154">
        <property type="entry name" value="AMP-dep_Lig_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011880">
        <property type="entry name" value="PA_CoA_ligase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14535">
        <property type="entry name" value="AMP-binding_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006444">
        <property type="entry name" value="PaaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02155">
        <property type="entry name" value="PA_CoA_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="2">
        <location>
            <begin position="81"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C_2" evidence="3">
        <location>
            <begin position="324"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR006444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH86707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="419" mass="46053" checksum="6976161DF26B87A5" modified="2015-07-22" version="1">MTPGELAAYQLDRLRATLRHAYDNVPLYRRKFDAAGVTPDDCRTLADLARFPFTTKDDLREGYPFGMFAVPVSDVRRLHASSGTTGLPTVVGYTAADLDTWSGLVARSIRAAGGRPGHRVHVAYGYGLFTGGLGAHYGAERLGCTVIPASGGMTARQVQLIRDFAPEVIMVTPSYMLTIIDEFERQGLDPRAGSLRVGIFGAEPWTEEMRHEIEERAGLDAVDIYGLSEVIGPGVAQECVETKDGLHVWEDHFLPEIVDPVTDEVRAAGEGGELVFTSLTKEAMPVVRYRTRDLSRLLPGTARPAFRRMEKVTGRCDDMIILRGVNVFPSQIEEIVLRTPGVAPHFQLRLTRHGRLDRMTIRAEARPGAPAEQWTAAGEAIARRVREGVGVGVEVEVVAPETLERSVGKIRRVVDEREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NK16</accession>
    <name>A0A0F7NK16_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_29945</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_29945"/>
    <dbReference type="EnsemblBacteria" id="AKH87132">
        <property type="protein sequence ID" value="AKH87132"/>
        <property type="gene ID" value="AA958_29945"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_29945"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6323"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH87132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="361" mass="40200" checksum="12CD117D836F135B" modified="2015-07-22" version="1">MLDKVCAATGWHRSHARNALLNAARPKPGRVPQRRKYDAEVVAALTLCWTILDRPAGKRLAPMLPELVPVLRRHRELSLDDESAELLMSMSAATISRRLAPYRQSSGTAPRLRPGSRPRGELPLVTWTEWDHGHPGFFEIAVVRHDGGTAGGSCLLTVAATDIATGWTEIRTVRGAGQIPLALEVVARNLPFPVLGLDCGSHGAEIDEALLRWCRQRRVTFTHARPVGRGSHHVGQQSWRMLHELAGHHHYDSPGEQALLNEIWAALSRLTNYFYPQQRSVSGPGQGGGRKEFETATPYRRTERHRCVTPEDQAILADVYPGLNPAELHRHVERLVKRLHLIAQSRAALRRCRTFGPGFAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A097H0W4</accession>
    <name>A0A097H0W4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">LTD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cnq722</name>
        <name evidence="4" type="ORF">AA958_30805</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="ChemBioChem" volume="15" first="2385" last="2392">
            <title>A Membrane-Bound Prenyltransferase Catalyzes the O-Prenylation of 1,6-Dihydroxyphenazine in the Marine Bacterium Streptomyces sp. CNQ-509.</title>
            <authorList>
                <person name="Zeyhle P."/>
                <person name="Bauer J.S."/>
                <person name="Steimle M."/>
                <person name="Leipoldt F."/>
                <person name="Rosch M."/>
                <person name="Kalinowski J."/>
                <person name="Gross H."/>
                <person name="Heide L."/>
            </authorList>
            <dbReference type="PubMed" id="25224759"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CNQ-509</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KJ451627">
        <property type="protein sequence ID" value="AIT42112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019104.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_30805"/>
    <dbReference type="EnsemblBacteria" id="AKH85876">
        <property type="protein sequence ID" value="AKH85876"/>
        <property type="gene ID" value="AA958_30805"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_30805"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6511"/>
    <dbReference type="OrthoDB" id="1580596at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001322">
        <property type="entry name" value="Lamin_tail_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036415">
        <property type="entry name" value="Lamin_tail_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00932">
        <property type="entry name" value="LTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74853">
        <property type="entry name" value="SSF74853"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51841">
        <property type="entry name" value="LTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007384434" description="LTD domain-containing protein" evidence="1">
        <location>
            <begin position="28"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="LTD" evidence="2">
        <location>
            <begin position="22"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIT42112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH85876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="165" mass="18056" checksum="D42249FA65EB1129" modified="2015-01-07" version="1">MRNHGVVSAIAAVGGALTMLAVTPAQAAEYSSPLKVRGVQYDAPGRDSHRCSGGNTHKEYLAIKNYSSSRTVNLKGWVVKDAAGNRFEFRANHYLQPGDHVKLRGGNGRDSDADNVVYRDNCNFMWNNDKDTIYLVKSSGSRADVHGYTKSADDRDGNGYITYHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MYF6</accession>
    <name>A0A0F7MYF6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_02690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014623.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_02690"/>
    <dbReference type="EnsemblBacteria" id="AKH81260">
        <property type="protein sequence ID" value="AKH81260"/>
        <property type="gene ID" value="AA958_02690"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_02690"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.574"/>
    <dbReference type="OrthoDB" id="1757088at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="131"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="226" mass="23311" checksum="0C1EFAD6F0552D7F" modified="2015-07-22" version="1">MYEERPVLLGGAVVWHRRDVRPGPYRVLPDGGTDLILTPGGLLVAGPDTVAHVGTGAAGDTYTGLRFAPGQGPAVLGVPAYELRNLRVPLADLWGERRARIAAERVAGAADPGAALEALARARLADAEPPEPYVPAVVAALAAGRPVAEVAGAVGLGERQLHRRSLAAFGYGPKTLARVLRMNRALALARAGTPPAAAAALAGYADQAHLAREMRALTGVPLTALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MYJ5</accession>
    <name>A0A0F7MYJ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_02925</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH81300">
        <property type="protein sequence ID" value="AKH81300"/>
        <property type="gene ID" value="AA958_02925"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_02925"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.625"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="141"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH81300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="290" mass="30529" checksum="E645B783EA69A2FE" modified="2015-07-22" version="1">MDGSDASLAALDWAVAESVRRGAELRIVYAPLWEPYERTWPEFAVARPRGRSVAEHVLVTAADRAREQGRGIEVETELLSGDPVPALLREAEKGTVLVVGDRGRGGHDALPLGSVALTVAARAACPVVVVRGEEAARRGEFGRIVLGTGNDGAEPAAVDFAFRAAQARGCRVTAVHSWRSPERGVATHAHTLGGTPDPRMREAEWALGRAVRAAVERHPDVPLERQSPEGLPRDTLLTAAAEADLVVLGARRTPLADATAGAGATGIQLGPVSHGVLHLAPCPVAVVRED</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MYS6</accession>
    <name>A0A0F7MYS6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">APH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_03465</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014753.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_03465"/>
    <dbReference type="EnsemblBacteria" id="AKH81395">
        <property type="protein sequence ID" value="AKH81395"/>
        <property type="gene ID" value="AA958_03465"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_03465"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.731"/>
    <dbReference type="OrthoDB" id="1457558at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="APH" evidence="2">
        <location>
            <begin position="97"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH81395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="352" mass="36165" checksum="FEEC22224AA8269F" modified="2015-07-22" version="1">MRARLVDRLAELSRGAGEPAVIVDRPDVTVVRGGGTVLKAHAPRLDPAALAVRLRVAAHPLLAGILLAPLGGLTGPVEGRYVSRWPYGTPVAPDAPEAAPWREAGHLIARLHAVPADRLPGPLPPMSGPANAARAIAALRAAQAAPAPRTPADSSPPPDGTRATVPAPPAPERVPAPAPAPYPAPAPGRTAAAVVLRAWARLPAWARDDEPRAQPRSLLCHGDLHLGQLVCHPAPDGPWHLIDVDDLGLGEPAWDLARPAAGYATGLIPAADWAAFLAGYRAARGPAVAPGDDLWPPEVDVPARTLTVQLAARALVDAATGARPLDGTDHDLLAACARIAGMEDGTEPGGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MZ00</accession>
    <name>A0A0F7MZ00_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glycerol-3-phosphate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_04080</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014860.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_04080"/>
    <dbReference type="EnsemblBacteria" id="AKH81505">
        <property type="protein sequence ID" value="AKH81505"/>
        <property type="gene ID" value="AA958_04080"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_04080"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.857"/>
    <dbReference type="OrthoDB" id="360065at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009331">
        <property type="term" value="C:glycerol-3-phosphate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004368">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006072">
        <property type="term" value="P:glycerol-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.870">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031656">
        <property type="entry name" value="DAO_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038299">
        <property type="entry name" value="DAO_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000447">
        <property type="entry name" value="G3P_DH_FAD-dep"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11985">
        <property type="entry name" value="PTHR11985"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16901">
        <property type="entry name" value="DAO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01001">
        <property type="entry name" value="FADG3PDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="6">
        <location>
            <begin position="39"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="DAO_C" evidence="7">
        <location>
            <begin position="425"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH81505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="540" mass="58002" checksum="D06EB16E31A1BFED" modified="2015-07-22" version="1">MTLPQTVPAAIPALGTHPTAGHTLGRAETRDLLARATYDLLVIGGGILGTSVAWHAAQSGLRVAMVDAGDFAGATSSASSKLVHGGIRYLQNGAVKLVAENHHERRVLARDVAPHLVNPLPFYLPLYKGGPHGAAKLGAGVFAYSALSGFRDGVGHLITPGRAARDVPALRTEGLKAVAVFGDHQMNDSRMAVMTVRAAVGAGAVVLNHAEVTGLRFTHGQVTGADLRDRLSGDEFGVDARLVLNATGPWVDHLRRLEDAAAAPSIRLSKGAHIVLKRRSPWRAAMSTWVDKYRVTFALPWEDQLLLGTTDEPYEGDPAAVHPTDADIAQIIDEASLSVRDDDLSPDLVTYAYAGLRVLPGGPGGTEQARRETVVTEGAGGMLSVAGGKWTTYRHIGRMVLRKLAKEHGGAIAEDMQPVKSLVRRTPLPGVANPNAVAHRLLVDRDPGHRMAPDTARQLATHYGSLSFDIARLANENPDLGERIHPDGPEIWAQVVYARDHEWAETEDDVLRRRTTVTIRGLDTADVRARVRELLARKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MZL7</accession>
    <name>A0A0F7MZL7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_02050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014515.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_02050"/>
    <dbReference type="EnsemblBacteria" id="AKH81151">
        <property type="protein sequence ID" value="AKH81151"/>
        <property type="gene ID" value="AA958_02050"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_02050"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.442"/>
    <dbReference type="OrthoDB" id="264136at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046306">
        <property type="entry name" value="DUF6421"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19985">
        <property type="entry name" value="DUF6421"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH81151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="469" mass="52883" checksum="B10F8E9F0522766B" modified="2015-07-22" version="1">MTEILASVTAEGDVLSAADGPRVVEHPAWARLKAAVEEIRPWQAKDGSIDFEAEGAPARPAAEDAVERAAAAVRELSPLVPHDAAYHDAVVADLRRWAADGFGVPDFLDSVLAFHPAEHRADGLQHLVVFPMYTQNGNPDRNFEAVVIRVVWPGWLAELERTRYDNPMFLGITFEDFTAGYDTNSAVLFPETIAMREVPPRFTWGAIFCDREAARFRRVSAAAVEATGLELPEEARGLLTDQDRAQQTFVLWDMVHDRTHSHGDLPFDPFMIKQRQPFWMYGIEELRCDLTAFHEAGKLAADGFPQGRDVQYTVLMDRLFRFPVTGERNRNYDGLGGQLLFAYLHKHDALRWTDNRLSVDWDLAREVTGRLRNEIETLYREGIDRPKLVHWFKAYDLVSTYLAPHPGSTWAKGPDALDLTKPPRKLVDDVLPDEFPLSMFYEALAKKLRKVIESTRGITAETAELADAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N016</accession>
    <name>A0A0F7N016_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alkyldihydroxyacetonephosphate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_02905</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_02905"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.621"/>
    <dbReference type="OrthoDB" id="1188552at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Oxid_FAD_bind_N"/>
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        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="96"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="537" mass="55441" checksum="34CCE5CC1B05CB5C" modified="2015-07-22" version="1">MDMLWNGWGDPGQAAPLPDGVRDLLRDLLGVRPADTPPVALAGLDVPPPRLGADVLDALAGAAGGAVHVRTDAAGRVRHTRGKSTPDLLRIRAGEVADAPDAVVLPGGHNEVLAVLRTCAERRVAVVPFGGGTSVTGGLAPYANGGGFSGVIALDLRRLDRLAALDEVARTAELDAGLRAPEAERLLGERGFTLGHFPQSFEWATVGGFAATRGSGQASAGYGRFDEMVVGLTVATPEGTLRLGRAPRSAAGPDLRQLVLGSEGAFGVITSVTVRVRPLPQVRAYEGWRFGSFDAGAAALRALAQDGPLPTVLRLSDETETMVGLARPEDLGAPDGSSPGGCLVVTGYEGAAGETADRRAAARVVLRAAGGESLGAEPGESWAAGRYRAPYLRDALLDAGAFAETLETAAFWPALPRLYEAVRGALTETLTAAGTPPLVMCHISHVYETGASLYFTVVGARGGDPLGAWERAKGAASDAILECGGTITHHHGVGTDHRPWYAREIGPLAVAALRAVKSTLDPAGVLNPGVLLPRADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N034</accession>
    <name>A0A0F7N034_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_06580</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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    </dbReference>
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    <dbReference type="PATRIC" id="fig|444103.5.peg.1373"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011703">
        <property type="entry name" value="ATPase_AAA-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041628">
        <property type="entry name" value="ChlI/MoxR_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07726">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17863">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="47"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="AAA_lid_2" evidence="3">
        <location>
            <begin position="240"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH81930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="345" mass="37607" checksum="9D96C47C8BE6F053" modified="2015-07-22" version="1">MTTYDERASLSDLTSTADDVRRSVESVIEGKPEAVRLSLTVLLAEGHLLIEDVPGVGKTMLAKALAKSIDCSVRRIQFTPDLLPSDITGVSVYDQQSRDFEFKPGAIFAQIVIGDEINRASPKTQSALLESMEERQVTIDTQTYELPSPFMVVATQNPIEMEGTYPLPEAQRDRFMARLSIGYPSPDAELEMLDVHGGVSPLGDLQPVAHAHDIVKLIDAVRTVHVADSVRRYAVDLVTSTRLHPELRLGASPRATLHLLRAAKAAAALAGREFTLPDDVQALAVHVLAHRLLPTAQAQLNRRTAEQIVAEILQQVPVPAADMQRPPQMPPAYGGGAHSPDGRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0R5</accession>
    <name>A0A0F7N0R5_9ACTN</name>
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        <submittedName>
            <fullName evidence="4">Sugar ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="4" type="ORF">AA958_08225</name>
    </gene>
    <organism evidence="4 5">
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        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
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    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015570.1">
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_08225"/>
    <dbReference type="EnsemblBacteria" id="AKH82220">
        <property type="protein sequence ID" value="AKH82220"/>
        <property type="gene ID" value="AA958_08225"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_08225"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1735"/>
    <dbReference type="OrthoDB" id="859573at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002518942" evidence="2">
        <location>
            <begin position="27"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_4" evidence="3">
        <location>
            <begin position="48"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH82220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="373" mass="39942" checksum="65FDFC174B61BC8B" modified="2015-07-22" version="1">MRTPRTPRIARLRTAAAVSALALALAACGQDSEGGSEEKKDGAEGGTIGIAMPTKSSERWIADGENMVKQFEAAGYETDLQYGEDKVENQVSQIDNMITKGVDALVVAAIDNTSLTEVLADAKEADIPVIAYDRLILETENVDYYASFDNERVGRLQGQYIVDALKLDEDKDAEYNIELFAGSPDDNNTRYFFDGAMAVLQPYLDSGQLTVRSGQTGLNQVTTLRWDGGTAQKRMDDLLSGNYGGGEDVDAVLSPYDGISIGVLSALKGAGYGSGGKELPVVTGQDAELASVKSIIAGEQTQTVYKDTRKLAKQAVQMTDAVLTGGKPEVNDTDTYDNGVKVVPAFLLDPVSIDKTNTDLLVEEGYYKAGDLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N114</accession>
    <name>A0A0F7N114_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_01705</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014457.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_01705"/>
    <dbReference type="EnsemblBacteria" id="AKH81093">
        <property type="protein sequence ID" value="AKH81093"/>
        <property type="gene ID" value="AA958_01705"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_01705"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.373"/>
    <dbReference type="OrthoDB" id="1403427at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH81093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="167" mass="18064" checksum="C9A77230E954978C" modified="2015-07-22" version="1">MAFLRRRSSAAKPAGPDFDVLAMDPGDWPGDLGAGLLPGPDGTCQGVFLRYDLFGGRGPAMIIGNLPEGSPARDVPEGQPPFEVAQLLLALEHEEPVTVTEVEDAPVMQGDNLLIVRRLKLSESRVSCVQFDRSDNVLVTIAAWDRPISEDLYALLKPLPAELFQQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N1D1</accession>
    <name>A0A0F7N1D1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nitrite reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_09010</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015692.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_09010"/>
    <dbReference type="EnsemblBacteria" id="AKH82345">
        <property type="protein sequence ID" value="AKH82345"/>
        <property type="gene ID" value="AA958_09010"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_09010"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1899"/>
    <dbReference type="OrthoDB" id="323168at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:molybdopterin cofactor binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="MoPterin_dinucl-bd_dom"/>
    </dbReference>
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        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
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    <dbReference type="Pfam" id="PF04879">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
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    <dbReference type="Pfam" id="PF01568">
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    <dbReference type="SMART" id="SM00926">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="SSF50692"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS51669">
        <property type="entry name" value="4FE4S_MOW_BIS_MGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="2 4" id="KW-0408">Iron</keyword>
    <keyword evidence="3 4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S Mo/W bis-MGD-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH82345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="704" mass="73833" checksum="935C74786B770219" modified="2015-07-22" version="1">MTVDTHCPYCSLQCGMTLAPAAAGDGLDVRERPAFDVNRGALCGKGRTAPAVLGSAARLTQPLVRDGRDDPGAPLRPASWAEALDRVAAGLAAARDGHGADAVGVFGGGGLTNEKAYALGKFARVVLGTSQIDYNGRFCMSSAAAAGTRAFGLDRGLPFPLADIPRTGCVILVGANPAETMPPALRYFTELRANGGTLVVVDPRRTRTAEQADLHLAPRPGTDLALALGLLHLVIAEGRTDDAYIAERTAGWPAARAAAMAHWPELVERITGVPVPQLRRAVALFCDPGAAMVLTARGPEQQSKGTDTVGAWIDLCLATGRPGRPYSGYGCLTGQGNGQGGREHGQKADQLPGYRLLTDPAARAHVAAVWGVDPGTLPGPGRSAYELLDALGAPGPDGVRALLLMGSNPVVSAPRAAHVERRLRSLDFLAVADVVLSETAALADVVLPVAQWAEETGTLTNLEGRVLLRRRAADPPPGVRGDLDVLRGLAERLAPARAAGFPVAAEEVFAELRRASAGGKADYSGITYARIEAEGGVFWPCPEGGEPVPRMFLDRFATPDGRARFSGAQHRPAAEETDAEYPVWLTTGRVLAQYQSGAQTRRVSELNAASPGPYVQMHPELAARVGADEGDPVAVLSRRGRAVAPARITTAIRPDTVFMPFHWPGAGRVNTVTNPALDPVSRMPEFKVCAVRIERAGRAGPAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N1R8</accession>
    <name>A0A0F7N1R8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Guanylate kinase</fullName>
            <ecNumber evidence="2 9">2.7.4.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">GMP kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">gmk</name>
        <name evidence="12" type="ORF">AA958_03090</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Essential for recycling GMP and indirectly, cGMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + GMP = ADP + GDP</text>
            <dbReference type="Rhea" id="RHEA:20780"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the guanylate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.8" evidence="2 9"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014690.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_03090"/>
    <dbReference type="EnsemblBacteria" id="AKH81329">
        <property type="protein sequence ID" value="AKH81329"/>
        <property type="gene ID" value="AA958_03090"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_03090"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.659"/>
    <dbReference type="OrthoDB" id="1502854at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004385">
        <property type="term" value="F:guanylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00328">
        <property type="entry name" value="Guanylate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017665">
        <property type="entry name" value="Guanylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020590">
        <property type="entry name" value="Guanylate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03263">
        <property type="entry name" value="guanyl_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00856">
        <property type="entry name" value="GUANYLATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Guanylate kinase-like" evidence="11">
        <location>
            <begin position="18"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="25"/>
            <end position="32"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AKH81329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="197" mass="21641" checksum="D8CD46375A3B2C57" modified="2015-07-22" version="1">MSTAFSRGAAPVPPADRPRLTVLSGPSGVGKSTVVAHLRKVHPEVWLSVSATTRRPRPGERHGVQYFFVSDDEFDKLVANGELLEWAEFSGNRYGTPRGPVLERLDAGEPVLLEIDLQGARLVRESMPDAMLVFLAPPSWDELVRRLTGRGTEPPEVIERRLAAARTELAAEEEFDTTLVNTSVEDVSAELLALMQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N208</accession>
    <name>A0A0F7N208_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DeoR faimly transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_00460</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH80887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014253.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_00460"/>
    <dbReference type="EnsemblBacteria" id="AKH80887">
        <property type="protein sequence ID" value="AKH80887"/>
        <property type="gene ID" value="AA958_00460"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_00460"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.108"/>
    <dbReference type="OrthoDB" id="1629121at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014036">
        <property type="entry name" value="DeoR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018356">
        <property type="entry name" value="Tscrpt_reg_HTH_DeoR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00455">
        <property type="entry name" value="DeoRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08220">
        <property type="entry name" value="HTH_DeoR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00037">
        <property type="entry name" value="HTHLACR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00420">
        <property type="entry name" value="HTH_DEOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00894">
        <property type="entry name" value="HTH_DEOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="4">
        <location>
            <begin position="3"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH80887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="258" mass="27428" checksum="38A67D5E36BA860E" modified="2015-07-22" version="1">MLAAERHRKIVAEISRLKFVTTDDLTTLLGVSQETIRRDLALLERRGELTRVHGGATSRQEPVGEEAPFAERSGILAEEKAAIGKAAAALVKPHQTVVIDVGTTALEVARALPADHVGVIATPSLLVAAEVSSRPGVEVLVSGGRVRAGDLACSNVRAVEFFADLRADTAFIGSGGIAQYGLTDFHLDEVATKRVMLANAAHRYVLADSGKLGRTAVHRVCELHGFDTLITDKPCPPELNTALSLAGAHVIVARRARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N263</accession>
    <name>A0A0F7N263_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">5'-3' exonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_03900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014831.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_03900"/>
    <dbReference type="EnsemblBacteria" id="AKH81474">
        <property type="protein sequence ID" value="AKH81474"/>
        <property type="gene ID" value="AA958_03900"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_03900"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.819"/>
    <dbReference type="OrthoDB" id="1220182at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033567">
        <property type="term" value="P:DNA replication, Okazaki fragment processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09898">
        <property type="entry name" value="H3TH_53EXO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020046">
        <property type="entry name" value="5-3_exonucl_a-hlix_arch_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002421">
        <property type="entry name" value="5-3_exonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020045">
        <property type="entry name" value="DNA_polI_H3TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038969">
        <property type="entry name" value="FEN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42646">
        <property type="entry name" value="PTHR42646"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01367">
        <property type="entry name" value="5_3_exonuc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02739">
        <property type="entry name" value="5_3_exonuc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00475">
        <property type="entry name" value="53EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="SSF47807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="53EXOc" evidence="2">
        <location>
            <begin position="1"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH81474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="302" mass="32259" checksum="0496C73F0165CF1A" modified="2015-07-22" version="1">MLLDSASLYFRAYFGVPESVTAPDGTPVNAVRGLLDFISRLVADYRPDDLVACMDADWRPQWRVDLIPSYKAHRVAEEHPGEEADEEVVPDTLSPQVPVIEEVLDALGIARVGVSPYEADDVIGTLAARAAGPVDIVTGDRDLFQLVDDARGVRVVYPVKGVGNATVMDGTALREKYGVDGSGYADLALLRGDPSDGLPGVPGIGEKTAAKLLDAYGDLAGIMAAVDDPSSRLTPAQRRRLAEARPYVEVAPKVVRVAADVPLPAYDPALPRTPRDPERLAALGKQWGLGGSLERLLTTLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N293</accession>
    <name>A0A0F7N293_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_07640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_07640"/>
    <dbReference type="EnsemblBacteria" id="AKH82126">
        <property type="protein sequence ID" value="AKH82126"/>
        <property type="gene ID" value="AA958_07640"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_07640"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1606"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002060">
        <property type="entry name" value="Squ/phyt_synthse"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00494">
        <property type="entry name" value="SQS_PSY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH82126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="329" mass="37087" checksum="1A43DCFA7A2F0DDC" modified="2015-07-22" version="1">MRTRELVAAGVRTGALVEAYTCCGKFLSRNNSAAYPAARALLYPAIRPYYDAILAFCGYADELLDDEATPISEREAAFDAWTAAFFDGSYEPDTDGAYSLDGRQGRLISRAFRHVIDTYGIELDSVREFLHTMRGDLHVTSYATYADLNGYMSGISGVHAGWMNALLETRHDDAQRIASSLGYGVYLLDFLADLREDLALGRVYLPTEDLARFGLDRAEFEQIVSRGVMTPSLRELVRFETVRVGQYFETADAWWRHVHPSSRELPRQYLALGRLSLQQLIRSDYDVFRSRPRGWLLATARARTGTGVSYLRARRDHRRHARSSAAVAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2C0</accession>
    <name>A0A0F7N2C0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nitroreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_04260</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014889.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_04260"/>
    <dbReference type="EnsemblBacteria" id="AKH81534">
        <property type="protein sequence ID" value="AKH81534"/>
        <property type="gene ID" value="AA958_04260"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_04260"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.893"/>
    <dbReference type="OrthoDB" id="1847197at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="2">
        <location>
            <begin position="16"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH81534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="186" mass="20223" checksum="928549896F380C33" modified="2015-07-22" version="1">MQHPQEPASGIHPLLAGRFSPYRFDPSAVVDDQALGLLLEAARWAPSAGNSQPWAFFTGRPREPEHDRVLPHLAPSSARWATDAGLLVVTLARRYVDDTQLLYSEFADYDLGQAVAHMTVQAQAMGLAAHQFRAFDLEGLTKELDPNPGWVIVSIVAVGKAAGGPPEGRDRRSIAHVRSAPWSPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2G9</accession>
    <name>A0A0F7N2G9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_04525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014933.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_04525"/>
    <dbReference type="EnsemblBacteria" id="AKH81578">
        <property type="protein sequence ID" value="AKH81578"/>
        <property type="gene ID" value="AA958_04525"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_04525"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.954"/>
    <dbReference type="OrthoDB" id="1457558at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd05154">
        <property type="entry name" value="ACAD10_11_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041726">
        <property type="entry name" value="ACAD10_11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="33"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="339" mass="36398" checksum="CA7F3631C0B66A56" modified="2015-07-22" version="1">MSDDHPPGLDPDALRRHLDAQLPGLVRGGLRARLVEGGRSNLTYDVTDGTGRWVVRRPPLGHVLATAHDMAREHRVLTALHPTPVPVPRTLLLCTDETVLGAPFYVMEYVPGTVYRTAGQLAPLGPARTRAVVEGLVDTLVRLHEVDPAEAGLAGFGRPDGFLERQLRRWGKQLDASRSRELPGIDELHDALARDLPPAAAPAVVHGDYRLDNVLVDAAGTVTAVLDWEMSTLGDPLTDLGLLAMYSAPAGADSPIATTADAPGHPAAAEIVARYAARSGRDVSRVAWYTAFAYFKLAVILEGIHYRFTLGQTVGAGFDRIGELVPRFIAGGRTTLQEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2Q8</accession>
    <name>A0A0F7N2Q8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_12370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
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    </evidence>
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</entry>
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</entry>
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    <sequence length="150" mass="16498" checksum="9AD28FD43D151864" modified="2015-07-22" version="1">MVARTRFDDSECPVARSVDAIGDWWSLLIVRDAFDGSRRFGEFQRSLGVAKNILTARLRTLVDGGVLASVPASDGSAYREYVLTPKGEALFPVIVALRQWGEENAFAPGEPHSELLDRREGRRLRGLEVLSADGRRLGPGETEVRKVSTG</sequence>
</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">CNQ-509</strain>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519102" evidence="2">
        <location>
            <begin position="32"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH82043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="290" mass="30549" checksum="53AEFB62EA95F72D" modified="2015-07-22" version="1">MNRTTPLRTSAATAAALATAVLAAGCGSEDASGSAGDGSRGDVDANARLYRVQATVLANGEHGPQLCRTLAESMPPQCGGPDIVGWEWDDVRAHRARDTTYTDPLDLVGTWDGERFTLAEKPRPAGGATEPRAPEAAADFDTPCADLKDGKDPKGGQDAPGSGEAGRQRVLDKAGKMPGYAGSWLDGDVVNIRFADAGEGGGPETAERELRGVWDGPLCVVGAEHTEEELTRVQRQVDEDVEGMLSSAVDPVRNAVTVEVVAATPELRRELDRTYGENTVRLSGWLEPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3Y4</accession>
    <name>A0A0F7N3Y4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)H dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_07345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AKH82073">
        <property type="protein sequence ID" value="AKH82073"/>
        <property type="gene ID" value="AA958_07345"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_07345"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1538"/>
    <dbReference type="OrthoDB" id="1143659at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003680">
        <property type="entry name" value="Flavodoxin_fold"/>
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    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02525">
        <property type="entry name" value="Flavodoxin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin_2" evidence="1">
        <location>
            <begin position="1"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="259" mass="28674" checksum="1CD53BC1BD00D953" modified="2015-07-22" version="1">MKTLIVYAHPEPKSLNGSLKDLAVSTLESAGHEVRVSDLYAMNWKAVVDAADYGPDASRPLKVALDSGRAFDAGTLTPDVLAEQEKLLWADTIIFQFPLWWYAMPAILKGWVDRVFTYHFAYGVGEHSDTKYGERFGEGTLVGRKALLSVTAGGTESHYAARGINGPIDDLLFPIQHGILYYPGIEVLPPFLLYGTDRMTGEDYPDVAKAWEQRLLTLESTEPIAFRRQNFGDYEIPSLHLKEGLEPAGRTGFGLHVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N421</accession>
    <name>A0A0F7N421_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-formimino-L-glutamate deiminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_11540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016097.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_11540"/>
    <dbReference type="EnsemblBacteria" id="AKH82761">
        <property type="protein sequence ID" value="AKH82761"/>
        <property type="gene ID" value="AA958_11540"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_11540"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2428"/>
    <dbReference type="OrthoDB" id="1592010at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010252">
        <property type="entry name" value="HutF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43608">
        <property type="entry name" value="PTHR43608"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02022">
        <property type="entry name" value="hutF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="1">
        <location>
            <begin position="52"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="446" mass="46282" checksum="15C5CE742AD918C0" modified="2015-07-22" version="1">MTTYWAEQAWVGGVVEPGVVLEPAASGGLLAAVRTAVPAPPPGATVLRGLTLPGLANAHSHAFHRALRGTVQVGSGTFWTWREVMYGVADRLTPGTYYDLARAVYAEMALAGITCVGEFHYVHHAPGGARYDDPNAMGHALIAAAAAAGIRLTLLDTAYLAAGFGQPPGRHQLRFSDGDGDAWAERAAALEPGDATVRVGAAAHSVRAVPAGQLATVAGWAAERRAPLHVHLSEQPAENEACVAAHGVTPARLLADHGVLGLRTTAVHATHLTADDLTLLGRSSTGVCMCPTTERDLADGIGPAAAVERAGSPLSLGSDSHAVIDLFEEARALELNERLRTRRRGHWTAHQLLRTATEGGYEALGWDAPARLEPGGLADFTTVALDSVRTAGAVPRLGAETAVFAATAADVRHTVVGGRHVVRDGVHALVEDVPGALTAAIAALRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N457</accession>
    <name>A0A0F7N457_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_07795</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_07795"/>
    <dbReference type="EnsemblBacteria" id="AKH82154">
        <property type="protein sequence ID" value="AKH82154"/>
        <property type="gene ID" value="AA958_07795"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_07795"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1640"/>
    <dbReference type="OrthoDB" id="1942930at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017196">
        <property type="entry name" value="ECF_substrate-spec_UCP037395"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024529">
        <property type="entry name" value="ECF_trnsprt_substrate-spec"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12822">
        <property type="entry name" value="ECF_trnsprt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037395">
        <property type="entry name" value="UCP037395_ABCper"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="276"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH82154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="314" mass="31842" checksum="D7AEC69B6DAB9477" modified="2015-07-22" version="1">MTAEEPGAVPGTPGGDAYANPSDTPGTTGTPGPADRPPAAAPARTPRLRVVRLGPVSAAALLLVSVIGVAAFGWPLLAGPDSGLAHSGDAPWLFAALLPLLVAVVGATIADAGLDAKAVAMLGVLAAVGAALRPLGAGTAGIEPMFFLMVLSGRVLGPGFGFVLGAVTMFASALLTGGVGPWMPFQMLAMGWVAMGAGLLPGAERLRGRRELWLLASYGAIASVLYGTVMNLQGWPYLSGMSTGVSFVAGDPLPENLARFVAYCLATSLGWDLPRAVVTAVCTLTLGRAVLAALRRATRKAAFSTPVTFETRNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4C6</accession>
    <name>A0A0F7N4C6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Para-aminobenzoate synthase</fullName>
            <ecNumber evidence="3">2.6.1.85</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_16300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.6.1.85" evidence="3"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016816.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_16300"/>
    <dbReference type="EnsemblBacteria" id="AKH83510">
        <property type="protein sequence ID" value="AKH83510"/>
        <property type="gene ID" value="AA958_16300"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_16300"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3434"/>
    <dbReference type="OrthoDB" id="1561172at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046820">
        <property type="term" value="F:4-amino-4-deoxychorismate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071704">
        <property type="term" value="P:organic substance metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd01743">
        <property type="entry name" value="GATase1_Anthranilate_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006221">
        <property type="entry name" value="TrpG/PapA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00566">
        <property type="entry name" value="trpG_papA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GATase" evidence="2">
        <location>
            <begin position="7"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH83510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="249" mass="25394" checksum="2B812F5CC4F22009" modified="2015-07-22" version="1">MSARILVVDNYDSFVFNLVQYLCQLDASCEVLRNDEVTPRHAVGPTSPKAGEGGFDGVLLSPGPGTPEQAGVCVDMVRHCAERGLPVFGVCLGLQSMAVAYGGVVGRAPELLHGKTSPVTHGGAGVFAGLPSPFTATRYHSLAVERESLPDELAVTAETDSGLVMGLRHRDLPVEGVQFHPESVLTEWGHRMLANWLVECGDAGAVERSAGLAPVTGGPVTGPAQGPAPDVAPVGGLAPAGGGAAGTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4K2</accession>
    <name>A0A0F7N4K2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Clp protease ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">AA958_16750</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Homohexamer. The oligomerization is ATP-dependent.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the ClpA/ClpB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016889.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_16750"/>
    <dbReference type="EnsemblBacteria" id="AKH83585">
        <property type="protein sequence ID" value="AKH83585"/>
        <property type="gene ID" value="AA958_16750"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_16750"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3524"/>
    <dbReference type="OrthoDB" id="44062at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028299">
        <property type="entry name" value="ClpA/B_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001943">
        <property type="entry name" value="UVR_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
        <property type="entry name" value="SSF81923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51903">
        <property type="entry name" value="CLP_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00871">
        <property type="entry name" value="CLPAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="Clp R" evidence="13">
        <location>
            <begin position="39"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="UVR" evidence="12">
        <location>
            <begin position="463"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="175"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="838"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="459"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="843"/>
            <end position="874"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AKH83585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="874" mass="94414" checksum="7BC1B0629B85403D" modified="2015-07-22" version="1">MSLSPLGSYGSSDPFSELLNRFFGMSPATSPPAVQRVPIGRLLTDSARELIGRAQRRAEEDGSVDLDTEHLLWACTQVDPARSVLAHAGADPDELARAVAEALPGEGSAASAEPELTPAAKRVLRGAVARSQANGTSYIGPEHILGALLDDPDAGAARLLGAYGTDTDRLRTGAEAATAHRAAGPATAAGRAAAPGGAQPQSETPTLDEYGRDITAEARAGRLDPVVGRAEEIEQTVEILSRRTKNNPVLIGEPGVGKTAIVEGLAQRIESGDVPQTLAGKRVVGLDLAGLVAGSKYRGEFEERLKKVIEEVKNTESSTILFIDELHTVVGAGSGGEGAMDAGNMLKPALARGELHVVGATTIDEYRKHVEKDAALERRFQPVLVPEPTVAETVQILEGLRDSYEAHHQVRFTDEALAAAAELSDRYVSDRFLPDKAIDLVDQAGARVRLRSMGRSTEVADREDRLAKLRREKDEAVAAERYEKASQLKERIAETEAELAGVEERREGVMEVTADDIAGVLSRSTGIPVAQLTESEKDKLLKLEDALHDRVVGQDEAVVAVAEAVRRGRAGMSDPDRPTGSFLFLGPTGVGKTELAKVLADLLFGDENRMIRFDMSEFQERHTVSRLLGAPPGYVGYDEAGQLTEKVRRRPYSVLLFDEIEKAHPDVFSALLQVLEDGRLTDAQGRTVDFRNTVVIMTSNIGAQRLLAHKGRVDEIRDELMEDLRGRFLPEFLNRIDEVIIFHGLTADDLASVVDLLLDRSRRRLRAQEVDLEVTEAAKKRLVALGHQPEFGARPLRRTLQRELDNRIANLLLDGSVRPGDTVLADVDGESGELVCTLARPRSSKAEKAEKAEKAEGAGAEREEGGPTGLRDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4K6</accession>
    <name>A0A0F7N4K6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-CoA synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_12530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016256.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_12530"/>
    <dbReference type="EnsemblBacteria" id="AKH82921">
        <property type="protein sequence ID" value="AKH82921"/>
        <property type="gene ID" value="AA958_12530"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_12530"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2633"/>
    <dbReference type="OrthoDB" id="1982614at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039543">
        <property type="entry name" value="POX18/UbiT/NSL-TP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003033">
        <property type="entry name" value="SCP2_sterol-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036527">
        <property type="entry name" value="SCP2_sterol-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10094">
        <property type="entry name" value="PTHR10094"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02036">
        <property type="entry name" value="SCP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55718">
        <property type="entry name" value="SSF55718"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP2" evidence="1">
        <location>
            <begin position="54"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="154" mass="16783" checksum="A0D6CB53DB6347D3" modified="2015-07-22" version="1">MTDDTSGLEGLDFAAVSPEEYARIVRGFSSREIGELARDEALRARVVGEVFRRMEQQFRPDRAGELEAVIRWRIAGVTEVVYDVTVSGGACSVREGAGEAKPRVTLDMGDEEFLNVTSGNAGPVKLFMTRKLKVTGDVALALKLTGMFDIPKAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4P6</accession>
    <name>A0A0F7N4P6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Saccharopine dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_09145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_09145"/>
    <dbReference type="EnsemblBacteria" id="AKH82363">
        <property type="protein sequence ID" value="AKH82363"/>
        <property type="gene ID" value="AA958_09145"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_09145"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1929"/>
    <dbReference type="OrthoDB" id="1006830at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005097">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03435">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sacchrp_dh_NADP" evidence="1">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="339" mass="36117" checksum="08F4156039FD5FE3" modified="2015-07-22" version="1">MFGAYGHTGRFVVAELAARGFVPVLSGRNAQTLRELADENGLEAREASVDDPASLDRALAGTAAVINCAGPFASTAGPVIEAALRAKIPYLDVAAELEANLDTFAHYRERARDAEAVIVPAMAFFGGLGDLLATAAMGDWTRADEAHIAYALSDWHPTAGTRLSGAVSRERRGGHRLRYRGGQWEHRTDAAPTLEWTFPEPMGSRPVIGEFTMADVVTVPQHLSIPDVTTYMTAEAARDVAAPHTPAPTAADERGRSNQTFLVDVVVRSGGAERRATAAGQDIYAVTAPLVTEALARVLTGRTKAIGVVSAGEVFDAPDFLHALDPHLTIDLHPRKQHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-12-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4S2</accession>
    <name>A0A0F7N4S2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_09150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015711.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH82364">
        <property type="protein sequence ID" value="AKH82364"/>
        <property type="gene ID" value="AA958_09150"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_09150"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1930"/>
    <dbReference type="OrthoDB" id="1459004at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="210"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="311" mass="33695" checksum="CB9803A040D6DBA4" modified="2015-07-22" version="1">MPLLALAVTDGMLHYELSVAAEIFGSDLTHVVDPWYDFSLCGSGPVHVGRFRLEPDHGLDHLAHADTVIVPGWADTDLDPPAELVEAVRAAHAAGARVASLCTGAFVLGAAGLLDGRRATTHWAHTQELARRHPSASVDPDVLYVDNGDVLTSAGKAAAMDLCLHLVRLDHGSANANKIARRLVVPPHRDGGQAQFIATPLPAPGSHPLGELLPWALERLDQPLTVEHLARQARMSSRHLGRHFKHLTGTTPLQWLHAQRIRHAQELLETTDATVDTIAAATGMGTATTLRRHFHRSVGVPPDTYRRTFRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4T0</accession>
    <name>A0A0F7N4T0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_13080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016339.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH83006">
        <property type="protein sequence ID" value="AKH83006"/>
        <property type="gene ID" value="AA958_13080"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_13080"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2752"/>
    <dbReference type="OrthoDB" id="2056482at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH83006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="111" mass="12262" checksum="94D7D707BFDA4B1C" modified="2015-07-22" version="1">MGNDGDRLAIPLSELDGFGGRLRSIKNRMNRTKATFESYRDDIGDSGVVDKLEDFESGWKDGRGDIDDQLTSLAEMSDTVVREAHKVDVDLENELKKGTKKEESQVGGGNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4U4</accession>
    <name>A0A0F7N4U4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_09315</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015740.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_09315"/>
    <dbReference type="EnsemblBacteria" id="AKH82394">
        <property type="protein sequence ID" value="AKH82394"/>
        <property type="gene ID" value="AA958_09315"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_09315"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1966"/>
    <dbReference type="OrthoDB" id="1617952at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016209">
        <property type="term" value="F:antioxidant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519123" description="Thioredoxin domain-containing protein" evidence="2">
        <location>
            <begin position="30"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="3">
        <location>
            <begin position="61"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH82394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="198" mass="20592" checksum="C66B23CC3A6B17ED" modified="2015-07-22" version="1">MRARTLLPAMLAAALLTLAGCGDGQDSRPADDAGASPSEVSSPAQPPDDDGGSRSDGGSAETQVPEALTFTATTVDGDPFDAKTLAGKPVVLWFWAPWCTVCQGQGHETAKVAAEFEGRAHVIGVAGLDKPQAMQDFVNDTEVGTFPHLSDEAGDVWKKFEITEQSVYVILDKDGKTVYEGVLPGGDGLADKLTAVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4X5</accession>
    <name>A0A0F7N4X5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_06145</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015210.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH81857">
        <property type="protein sequence ID" value="AKH81857"/>
        <property type="gene ID" value="AA958_06145"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_06145"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1284"/>
    <dbReference type="OrthoDB" id="1373245at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH81857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="107" mass="12163" checksum="544EC521D7CE16C0" modified="2015-07-22" version="1">MAGNQPGADDEPRLPDDIWERFQRDSLGQIEATAPKERSARWYEVTERLAAEEARREAAPKEHRMRRPRPRMPHAPVPRALTVCLVLVSVVLVLSAAAAYLQYGRVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N585</accession>
    <name>A0A0F7N585_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LacI family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_10245</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015886.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH82544">
        <property type="protein sequence ID" value="AKH82544"/>
        <property type="gene ID" value="AA958_10245"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_10245"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2159"/>
    <dbReference type="OrthoDB" id="664909at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="3"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH82544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="347" mass="35568" checksum="C7C8713574993EBA" modified="2015-07-22" version="1">MAVTLADVAARARVSAATVSRVLSGNYPVAEATRARVLAAVDELDYVINGPASALAAATSDLVGVLVNDVADPFFGIMASAVQSELGSEKLAVVCNTGGSPERELTYLTLLLRQRAAAVVITGSAVETPEYAAASAAKVGRLAANGTQVVLLGRPASAAPEGSAVAVEFGNREGGRRLTEHLISLGHRRIGYVAGPADRTTTRHRLEGHRAALAAHDLGGDAGELGRLTVHGPYSRKSGYDGALELLDREPGLTAIVGSNDAVALGICAALREKGLDVPGDISVAGFDDLPFSADATPALTTVRLPLQEAAARAARLALGREESPADGRYMVPAELVARASTAAPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5D2</accession>
    <name>A0A0F7N5D2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Na(+)/H(+) antiporter NhaA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Sodium/proton antiporter NhaA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">nhaA</name>
        <name evidence="10" type="ORF">AA958_14400</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>2 H(+)(out) + Na(+)(in) = 2 H(+)(in) + Na(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29251"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016542.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH83226">
        <property type="protein sequence ID" value="AKH83226"/>
        <property type="gene ID" value="AA958_14400"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_14400"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3030"/>
    <dbReference type="OrthoDB" id="1805428at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015081">
        <property type="term" value="F:sodium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006885">
        <property type="term" value="P:regulation of pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01844">
        <property type="entry name" value="NhaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023171">
        <property type="entry name" value="Na/H_antiporter_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004670">
        <property type="entry name" value="NhaA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30341">
        <property type="entry name" value="PTHR30341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06965">
        <property type="entry name" value="Na_H_antiport_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00773">
        <property type="entry name" value="NhaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0050">Antiport</keyword>
    <keyword evidence="4 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0915">Sodium</keyword>
    <keyword evidence="8" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="197"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="225"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="308"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="347"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="381"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="444"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AKH83226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="465" mass="49805" checksum="8581ED116D00D060" modified="2015-07-22" version="1">MTAPQRPQQSQFLPRPSPKESKFLTEALRTETVGGLILLAAAVIALVFANTALSGTYEDIKGFTFGPSALDLRLDLAHWAKDGLLTIFFFVVGVELKRELVDGELKDPRAAALPIVAALCGMAAPALFYVAVNAGRGDLGGWAIPTATDIAFALAVLAVIGSNLPSALRAFLLTLAVVDDLFAILIIAIFYTSGINLVALGSALAGLVLFWFLQRQEIRGWYVYLPLALVIWALMHASGVHATIAGVAMGLMLRVTTRPGEEVSPGERIEHQMRPLSAGIAVPVFAFFAAGVAVNADSLGGVFTDPEPLGVVLGLVLGKVLGISLGSWLAARFTRAELNPALRWPDVFAVATLAGIGFTVSLLISELAFTDDPGLAEETKAAVLTGSFIAAVLACVMLKIRDNRYKAIAEEDERDEDMDGIADIYQQDDPEYHLRMAAIHEAKAAEHRRRAEMRHPPGEQGDRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5E7</accession>
    <name>A0A0F7N5E7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_14580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016566.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_14580"/>
    <dbReference type="EnsemblBacteria" id="AKH83251">
        <property type="protein sequence ID" value="AKH83251"/>
        <property type="gene ID" value="AA958_14580"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_14580"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3071"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH83251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="721" mass="76535" checksum="847979CFCD5FE4D8" modified="2015-07-22" version="1">MTDPVSLAAISGVLGAIGMGMANEVGRAAWETTGALVRRAAGREVRAPGRASDVERVAALLREGAARDPELARLWERFASTLPAGSGPGSVGAPRLPAATRHFTDRRPALRLLDREADRKFDGRPRVALLHGPEGIGTSATALFWGSRRAADFPDGQVHVDLHGWSSQSALGPAVVAGRLLRELGLLAEETPHAADGRLDLWRRLVGELRLLVVLDHAYSAAQVRPLLTSAPGVFTLVTARHPLPGLDAVPVALGPLAAKDARRLLTHFAGPEAVAAAPDTAKDLLVRCAGSPYALRTAAPLLSVHDDTARGAADAAGPVAALTESAYRALDADAARMYRLLALRDWPHIDARTAAWATQPDQPLAPDPDATPAAALLGLLADRGLLEPAGTGRYRFRPAVRRHAELLARHEDGPHACAESAARVVRGYADLAEDAAHQALPESWRVPRPSRPGPPLGKAEALGTLVREAANVLEAVQAAADAGDRAAAVRLARALWPLQLKAGRHAEAVPALRAALRLPAPESEPRATGLRDRAALRDRAALRFQLAMSLTELGEHAEAETEFLAAAEDDRTAGHIRGHASAVEALGLLRLRQWAGPEALALFDRADTLYGTIAPGEEGHADLRRARPLLVRHRGRALRLDGRFEEAIALLRTAVGSFGEIGDDYNRARALTDLAETHVLAAAPARGLPLIDEAIALLDAQRAEHPLAYARSVRARCVTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5G1</accession>
    <name>A0A0F7N5G1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_14885</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016606.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_14885"/>
    <dbReference type="EnsemblBacteria" id="AKH83291">
        <property type="protein sequence ID" value="AKH83291"/>
        <property type="gene ID" value="AA958_14885"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_14885"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3137"/>
    <dbReference type="OrthoDB" id="1020672at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="2"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="125"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="125"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH83291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="220" mass="23656" checksum="1DA348D2961041B4" modified="2015-07-22" version="1">MRVLVAEDHRILARTVATGLRRQAMAVDVAHAGDEAERMCLLTAYDVLILDRDLPGLSGDEVCRRLRAAGGPPRILMLTAAGEVTCKVYGLTALGADDYLAKPFDFAELVARVRTLSRRAQKPAPGALEFAGIVLDPVRHRVHAHGRPVDLTPREFAVLHLLLRAGGAPVPHDTLVRSVWDEHLDPRTSAVRATVSRLRGKPGGGGVIAADTGEGYRLCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-08-12" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5Q8</accession>
    <name>A0A0F7N5Q8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LytR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_11440</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LytR/CpsA/Psr (LCP) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016079.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH82743">
        <property type="protein sequence ID" value="AKH82743"/>
        <property type="gene ID" value="AA958_11440"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_11440"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2408"/>
    <dbReference type="OrthoDB" id="491753at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004474">
        <property type="entry name" value="LytR_CpsA_psr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03816">
        <property type="entry name" value="LytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00350">
        <property type="entry name" value="lytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="LytR_cpsA_psr" evidence="4">
        <location>
            <begin position="114"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="362"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH82743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="387" mass="42362" checksum="74FE6C8A06D4C15F" modified="2015-07-22" version="1">MGADETGPREGASPYQADPPPPRRPRPRSRRRVLARRVGLGLAVFLLALSGVGWYFYQRFDSNITVDSATARELKRYEAERPAPAAGGATNILVLGSDSRAGSERYGHDTGVERSDTAVLLHLAGDRDGVTAVSIPRDLMVKIPDCRRPGGGTSGKQVNQFNFSFAYGGAACTIRVVEKLVGVRVDHHVIADFQGFKEVVDAVDGVEVCLPAAMHDRSAKLRLPKGRQVLDGEQALGYVRARKSLDGGGDTQRMSRQQEFMASLVNKVQSNGVLFNPLRLAPLLDAVTSALTANEELSSLTELYDLVRVVRDVPQERVHFMTVPRRPYRLDSNRDELAQPAARELFGALRTDSVVRFVSEGRKAKQKRDSGAPPVYKGTTPVDDICR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5Y8</accession>
    <name>A0A0F7N5Y8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_15900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the fructosamine kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016758.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_15900"/>
    <dbReference type="EnsemblBacteria" id="AKH83446">
        <property type="protein sequence ID" value="AKH83446"/>
        <property type="gene ID" value="AA958_15900"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_15900"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3350"/>
    <dbReference type="OrthoDB" id="1457558at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016477">
        <property type="entry name" value="Fructo-/Ketosamine-3-kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12149">
        <property type="entry name" value="PTHR12149"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03881">
        <property type="entry name" value="Fructosamin_kin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006221">
        <property type="entry name" value="Ketosamine-3-kinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="141"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="141"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR006221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH83446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="336" mass="34407" checksum="75FE1AA65789BFD4" modified="2015-07-22" version="1">MSPPPAGAARGAGNAPRAVEARAAALAGAPVRTAIPVGGGDISAAHRLELADGRRVFAKTRAGAPADFFAAEAHGLRLLAETGTVPVPAVLGEEPGMILLEWVEPGPATAAQAERLGRDLAALHATPAAAFGTPWPAYIGSLPLPSPGPPGTPDPPGTADTPGPPDPAPEPPPEHTGHAPASPADWPAFYAGHRLLPFLRLATDNGALTPADTRAVERLCDVIDQVTGPPQPPAVIHGDLWSGNVQWSAGDRAYLIDPAAQGGHPEVDLAFLELFGCPQLGRLLAAYEEVRPLPGRRGRVPLYQLHHLLVHAALFGSGYGAQCGAAARAALEGAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N616</accession>
    <name>A0A0F7N616_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_19690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017322.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_19690"/>
    <dbReference type="EnsemblBacteria" id="AKH84030">
        <property type="protein sequence ID" value="AKH84030"/>
        <property type="gene ID" value="AA958_19690"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_19690"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4149"/>
    <dbReference type="OrthoDB" id="2040599at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd06260">
        <property type="entry name" value="DUF820"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1570.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012296">
        <property type="entry name" value="Nuclease_put_TT1808"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008538">
        <property type="entry name" value="Uma2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05685">
        <property type="entry name" value="Uma2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uma2" evidence="1">
        <location>
            <begin position="29"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="192" mass="21367" checksum="27DD56AFAA19E1B5" modified="2015-07-22" version="1">MALTTPEREVLVPANHPVEDAFFAASAAVPRGWRVELIEGQIHVTPPANAEHEDFVSGMHEQVRDHRRDVRMYHGIGLKLSGPDPGLRVIPDLVVAPKRAFQAELEWHDPDPVLLVAEVTSKSTARNDRLKKLRGYARAGIPLYLLIDREAGVVSVFSRPKAGQYARSESATLGEKIMLPKPFDFELDTAEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N627</accession>
    <name>A0A0F7N627_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">6-phosphogluconate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_16220</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 6-phosphogluconate dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016802.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_16220"/>
    <dbReference type="EnsemblBacteria" id="AKH83496">
        <property type="protein sequence ID" value="AKH83496"/>
        <property type="gene ID" value="AA958_16220"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_16220"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3418"/>
    <dbReference type="OrthoDB" id="1245550at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004616">
        <property type="term" value="F:phosphogluconate dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019521">
        <property type="term" value="P:D-gluconate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016054">
        <property type="term" value="P:organic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004849">
        <property type="entry name" value="6DGDH_YqeC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006114">
        <property type="entry name" value="6PGDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006184">
        <property type="entry name" value="6PGdom_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006183">
        <property type="entry name" value="Pgluconate_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11811">
        <property type="entry name" value="PTHR11811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00393">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00076">
        <property type="entry name" value="6PGDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01350">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00872">
        <property type="entry name" value="gnd_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00461">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0311">Gluconate utilization</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6PGD" evidence="3">
        <location>
            <begin position="160"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH83496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="292" mass="31624" checksum="A5B2A5468E580917" modified="2015-07-22" version="1">MELGLVGLGRMGGNMRERIRRAGHTVVGYDHNPDRADVHSLRELVDALPAPRVVWVMVPAGAATQSTVDELAELLEPGDVLVDGGNSRWTDDEKHAVELGAKGIGFVDCGVSGGVWGLENGYALMYGGDAEHVARVQPVFDALKPEGEYGAVHAGKVGAGHFAKMVHNGIEYAMMQAFAEGWELLEAADSVTDVREVFRSWQEGTVIRSWLLDLAVRALDDDEHLGKLRGYAEDSGEGRWTVEAAIDHAVPLPAITASLFARFASRQDDSPQMKMIAALRNQFGGHAVKEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6D4</accession>
    <name>A0A0F7N6D4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH_30 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_12520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016254.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_12520"/>
    <dbReference type="EnsemblBacteria" id="AKH82919">
        <property type="protein sequence ID" value="AKH82919"/>
        <property type="gene ID" value="AA958_12520"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_12520"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2630"/>
    <dbReference type="OrthoDB" id="1439158at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_30" evidence="1">
        <location>
            <begin position="335"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="403" mass="44498" checksum="ECEC66A0B9C262C2" modified="2015-07-22" version="1">MPDAGPAAGLVGPPEPLPPEFAAIMRPELPSLVEEIAQEIRKAIPEYSRLLEGPYGEVLQQGVEQNLSTFVEQVANPKSSTARWDDMCRRLGRFEAYEGRSFQYLRSALRIGARVALRRAKKVGARYNMSPTLMAMFADAVFAHVDATEELCREGYREAQSGPEDAGARRRRLLRLLLTGGTLPLAHPAVTDLAERAGWPLPEVATPVALAGERRPDPESLPDDVLAELSDPQPHLLVPGRLTGLRRTGCETALAGCRAAIGMTVPLGRSADSLRWARQALVHAESGIIRDAPVFACDDHLVTLWLMADPPLAEELARRQLAPLAGHTPVRRERLVDTLRVWLTTRGTAARMARMLHVHPQTVRYRLRSLHQLFGAQLDDHDERFAVEVAVRTLHLRQRGDGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6E4</accession>
    <name>A0A0F7N6E4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_17000</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016930.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_17000"/>
    <dbReference type="EnsemblBacteria" id="AKH83626">
        <property type="protein sequence ID" value="AKH83626"/>
        <property type="gene ID" value="AA958_17000"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_17000"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3575"/>
    <dbReference type="OrthoDB" id="1438064at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="193"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH83626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="225" mass="23971" checksum="2D7D710E4C3543B9" modified="2015-07-22" version="1">MSDYAISDDSFVPLKIVIAGGFGVGKTTMVGAVSEIPPLTTEETLTAASVDHDSLDGVPEKDATTVAMDFGRITLTAHHMMLLLFGTPGQKRFWFMWDHLASGAIGAVVLADTRRLADCFAAVEYFERRGLPFVVGINEFDDAYHYTPEEVKAALHLRSDTPVMCCDARATSSARSLLIRLVEHAHARSVAARAGVSAEPEPATGAVSASESAQPVPTSPPRSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-10-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6I8</accession>
    <name>A0A0F7N6I8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_17405</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH83691">
        <property type="protein sequence ID" value="AKH83691"/>
        <property type="gene ID" value="AA958_17405"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_17405"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3661"/>
    <dbReference type="OrthoDB" id="2040681at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH83691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="68" mass="7082" checksum="E50A9B8B14CFD108" modified="2015-07-22" version="1">MRANTGKKFDSALDAFRTGYPDVEVEPALLDGEVAPRLLEQGADAEPGAPRAATPPPMPFATIALVCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6W2</accession>
    <name>A0A0F7N6W2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fur family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_13685</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Fur family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016439.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_13685"/>
    <dbReference type="EnsemblBacteria" id="AKH83109">
        <property type="protein sequence ID" value="AKH83109"/>
        <property type="gene ID" value="AA958_13685"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_13685"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2880"/>
    <dbReference type="OrthoDB" id="1630127at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07153">
        <property type="entry name" value="Fur_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002481">
        <property type="entry name" value="FUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043135">
        <property type="entry name" value="Fur_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33202">
        <property type="entry name" value="PTHR33202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01475">
        <property type="entry name" value="FUR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH83109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="150" mass="16771" checksum="3BE9777E21226FA6" modified="2015-07-22" version="1">METTDWKRDLRERGYRLTPQRQLVLEAVDSLEHATPDGILSEVRKTAAGVNISTVYRTLELLEELGLVSHAHLNHGPPTYHIADRHHHLHLVCRVCDRVIEAENAVAEPFAETLRQRFGFESDVQHFAILGRCATCTEAGATDAAAPSRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7L2</accession>
    <name>A0A0F7N7L2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Uracil phosphoribosyltransferase</fullName>
            <ecNumber evidence="3 11">2.4.2.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">UMP pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">UPRTase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">upp</name>
        <name evidence="12" type="ORF">AA958_15265</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>diphosphate + UMP = 5-phospho-alpha-D-ribose 1-diphosphate + uracil</text>
            <dbReference type="Rhea" id="RHEA:13017"/>
            <dbReference type="ChEBI" id="CHEBI:17568"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="11">Allosterically activated by GTP.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uracil: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the UPRTase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.9" evidence="3 11"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016662.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_15265"/>
    <dbReference type="EnsemblBacteria" id="AKH83349">
        <property type="protein sequence ID" value="AKH83349"/>
        <property type="gene ID" value="AA958_15265"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_15265"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3215"/>
    <dbReference type="OrthoDB" id="1581906at2"/>
    <dbReference type="UniPathway" id="UPA00574">
        <property type="reaction ID" value="UER00636"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004845">
        <property type="term" value="F:uracil phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044206">
        <property type="term" value="P:UMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006223">
        <property type="term" value="P:uracil salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01218_B">
        <property type="entry name" value="Upp_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034332">
        <property type="entry name" value="Upp_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005765">
        <property type="entry name" value="Ura_phspho_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01091">
        <property type="entry name" value="upp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="5 11 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11 12" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="5-phospho-alpha-D-ribose 1-diphosphate binding" evidence="11">
        <location>
            <begin position="130"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Uracil binding" evidence="11">
        <location>
            <begin position="200"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>uracil</name>
            <dbReference type="ChEBI" id="CHEBI:17568"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AKH83349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="210" mass="22720" checksum="A30FB7791C008757" modified="2015-07-22" version="1">MRIHVVDHPLVAHKLTTLRDERTDSPTFRRLADELVTLLAYEATRDVRTEQVDVRTPVAQTTGVRLARPKPLIVPILRAGLGMLDGMMRVLPTAEAGFLGLIRDEETLQPSTYANRLPEDLSGRQVYVLDPMLATGGTLVASIRELIRRGADDVTAICLLAAPEGTDAVEHELAGAPVTVVTAAMDERLNEAGYIVPGLGDAGDRMYGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7U1</accession>
    <name>A0A0F7N7U1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UPF0232 protein AA958_16230</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_16230</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the UPF0232 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016804.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_16230"/>
    <dbReference type="EnsemblBacteria" id="AKH83498">
        <property type="protein sequence ID" value="AKH83498"/>
        <property type="gene ID" value="AA958_16230"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_16230"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3420"/>
    <dbReference type="OrthoDB" id="1918294at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00630">
        <property type="entry name" value="UPF0232"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007922">
        <property type="entry name" value="DUF721/UPF0232"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023007">
        <property type="entry name" value="UPF0232_actinobac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05258">
        <property type="entry name" value="DciA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH83498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="194" mass="20129" checksum="9C448A2C11D49BD7" modified="2015-07-22" version="1">MSEEPVRPGGARQDPSADSGAAESPAAPEPSGVDLARVALRAARAEARARGAAAQQRRQARRGGGLRSGARADGRDPLPLGAAVSRLITERGWEAPAAVGGVMGRWPQLVGPEVAQHCAPERYDEQERVLVVACDSTAWATQLRLLAPQLVARLNEELGHGTVKLIKVVGPGGGGRRFGPLRAPGSQGPGDTYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7X0</accession>
    <name>A0A0F7N7X0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Histidinol-phosphatase</fullName>
            <ecNumber evidence="5">3.1.3.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Histidinol-phosphate phosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AA958_23565</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + L-histidinol phosphate = L-histidinol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14465"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57699"/>
            <dbReference type="ChEBI" id="CHEBI:57980"/>
            <dbReference type="EC" id="3.1.3.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 8/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the inositol monophosphatase superfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.15" evidence="5"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017945.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_23565"/>
    <dbReference type="EnsemblBacteria" id="AKH84690">
        <property type="protein sequence ID" value="AKH84690"/>
        <property type="gene ID" value="AA958_23565"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_23565"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4967"/>
    <dbReference type="OrthoDB" id="1741160at2"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00013"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004401">
        <property type="term" value="F:histidinol-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046855">
        <property type="term" value="P:inositol phosphate dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011809">
        <property type="entry name" value="His_9_proposed"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020583">
        <property type="entry name" value="Inositol_monoP_metal-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00377">
        <property type="entry name" value="IMPHPHTASES"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02067">
        <property type="entry name" value="his_9_HisN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00629">
        <property type="entry name" value="IMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AKH84690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="264" mass="28505" checksum="D70E94E182B1DAD5" modified="2015-07-22" version="1">MAGFHDDLRLAHVLADAADATTMERFKALDLKVETKPDLTPVSEADRSAEELIRSSLRRARPRDAVMGEEYGTEGTGPRRWIIDPIDGTKNYVRGVPVWATLIALMAPGPEGNQPVVGVVSAPALGRRWWAVQGGGAYTGRSLAKASPLRVSGVQRIEDASFAYSSLHGWDERGRLDGFLHLTRDCWRSRGYGDFWPYMMVAEGTVDICAEPELSLWDMAACAAIVAEAGGSFTGLDGEPGPHSGNAAASNGLLHQELLKYLGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N890</accession>
    <name>A0A0F7N890_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_13000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016326.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH82992">
        <property type="protein sequence ID" value="AKH82992"/>
        <property type="gene ID" value="AA958_13000"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_13000"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2736"/>
    <dbReference type="OrthoDB" id="1996989at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519165" evidence="1">
        <location>
            <begin position="29"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="122" mass="13197" checksum="8EE74AB374F14A2B" modified="2015-07-22" version="1">MLKRKKTAVALATGAMALGLLGAAPVAATTTTGHAPAMKTWEDDWRASQRGVVIAKPGVLIRSQPTTASHEKGFIPRGEIVWIDCKVEGQDVFGNSLWYKIGSHNGFIAARWVKNVDHIPFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8I1</accession>
    <name>A0A0F7N8I1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_18190</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_18190"/>
    <dbReference type="EnsemblBacteria" id="AKH83818">
        <property type="protein sequence ID" value="AKH83818"/>
        <property type="gene ID" value="AA958_18190"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_18190"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3824"/>
    <dbReference type="OrthoDB" id="1220759at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003788">
        <property type="entry name" value="NDUFAF7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038375">
        <property type="entry name" value="NDUFAF7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12049">
        <property type="entry name" value="PTHR12049"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02636">
        <property type="entry name" value="Methyltransf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH83818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="372" mass="38022" checksum="6166815525F408EB" modified="2015-07-22" version="1">MENGGTGGRGAGAEAGAGPGAGSQAGPEPGPETASGGGSGAGGRLRWREAMLRALYGPEGFYRRGGPGTGAAAHFRTSVHASPLFAAAVAELVRRTAVALGRPAELDVVDVGAGRGELLTGVLAAYEGPGRLRAYAVEVGPPPEEPDGRITWLARPPEGVRGLLFANEWLDNVPVEVAETDGQGVPRYVEVAADGTERLGAEVRGADAEWLRRWWPLAGAPPGSRAEIGAPRDAAWSAALTTLTAGLALTADYAHTRAARPPYGTLTAFRDGQEVRPVPDGSCDVTAHVALDAVAAAAPERGGPALLMSQREALRGLGLDGSRPPLALARTDPAGYLRRLATAGQAAELLDPAGLGGFTWLAHHVGIAPVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8M3</accession>
    <name>A0A0F7N8M3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">Polyphosphate kinase</fullName>
            <ecNumber evidence="6 7">2.7.4.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP-polyphosphate phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Polyphosphoric acid kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ppk</name>
        <name evidence="13" type="ORF">AA958_13550</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>[phosphate](n) + ATP = [phosphate](n+1) + ADP</text>
            <dbReference type="Rhea" id="RHEA:19573"/>
            <dbReference type="Rhea" id="RHEA-COMP:9859"/>
            <dbReference type="Rhea" id="RHEA-COMP:14280"/>
            <dbReference type="ChEBI" id="CHEBI:16838"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="PTM">
        <text evidence="6 7">An intermediate of this reaction is the autophosphorylated ppk in which a phosphate is covalently linked to a histidine residue through a N-P bond.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the polyphosphate kinase 1 (PPK1) family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.1" evidence="6 7"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016417.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_13550"/>
    <dbReference type="EnsemblBacteria" id="AKH83087">
        <property type="protein sequence ID" value="AKH83087"/>
        <property type="gene ID" value="AA958_13550"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_13550"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2851"/>
    <dbReference type="OrthoDB" id="76567at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009358">
        <property type="term" value="C:polyphosphate kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008976">
        <property type="term" value="F:polyphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006799">
        <property type="term" value="P:polyphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1840.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00347">
        <property type="entry name" value="Polyphosphate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003414">
        <property type="entry name" value="PP_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041108">
        <property type="entry name" value="PP_kinase_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024953">
        <property type="entry name" value="PP_kinase_middle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036830">
        <property type="entry name" value="PP_kinase_middle_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025200">
        <property type="entry name" value="PPK_C_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025198">
        <property type="entry name" value="PPK_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036832">
        <property type="entry name" value="PPK_N_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30218">
        <property type="entry name" value="PTHR30218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02503">
        <property type="entry name" value="PP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13090">
        <property type="entry name" value="PP_kinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17941">
        <property type="entry name" value="PP_kinase_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13089">
        <property type="entry name" value="PP_kinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015589">
        <property type="entry name" value="PP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140356">
        <property type="entry name" value="SSF140356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03705">
        <property type="entry name" value="poly_P_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1 6 7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PP_kinase_N" evidence="10">
        <location>
            <begin position="66"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="PP_kinase" evidence="9">
        <location>
            <begin position="181"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="PP_kinase_C_1" evidence="12">
        <location>
            <begin position="390"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="domain" description="PP_kinase_C" evidence="11">
        <location>
            <begin position="563"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphohistidine intermediate" evidence="6">
        <location>
            <position position="495"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="435"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="465"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="528"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="624"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="652"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003800"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13089"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF13090"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF17941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AKH83087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="751" mass="83765" checksum="FD6669AB1502D936" modified="2015-07-22" version="1">MDDSSPLVTQPAQPAQPSVGSIAARRPHAVAPAAQRAAQQIDPDIDADADDYDGQEADEELPQGRFLDRERSWLAFNERVLELAEDPATPLLERANFLAIFASNLDEFFMVRVAGLKRRIATGVATRSASGLQPREVLDLIWNRSRELMARHAACFQQDVQPALADEGIALVRWADLGEKEQARLFTLFRQQIYPVLTPLAVDPAHPFPYISGLSLNLAVVVRNPVSGHRHFARVKVPPLLPRFLETASVGGAQRFVPLEDVIAAHLEDLFPGMEVLAHHTFRVTRNEDLEVEEDDAENLLKALEKELMRRRFGPPVRLEVEESIDPYVLDLLVRELKISEAEVYPLPGPLDLTGLFGIAAQDRPELKYPKFVAGTHRDLAEVESASAPDVFAALRERDVLLHHPYDSFSTSVQAFLEQAAADPDVLAIKQTLYRTSGDSPIVDALIDAAESGKQVLVLVELKARFDEQANIKWARKLEEAGCHVVYGLVGLKTHCKLSLVVRQEGETLRRYSHVGTGNYHPKTARLYEDLGLLTADPQVGADLSDLFNRLSGYSRRENYRRLLVAPTSVREGLVHRIHREITHHRAGQPAYVRIKVNSIVDEAVIDACYRASAAGVPVDIWVRGICAVRPGVPGLSENIRVRSVLGRFLEHSRVFVFGNGGEPEVWFGSADMMHRNLDRRIEALVRVADTAHREALNRLLETGMSDTVDSWRLDSNGDWTRNAVDDAGNRLANVQEMLIDARRRRRVIAA</sequence>
</entry>
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    <accession>A0A0F7N8N4</accession>
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                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AKH84880">
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        <property type="gene ID" value="AA958_24755"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_24755"/>
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH84880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="87" mass="9388" checksum="348E300011A7B250" modified="2015-07-22" version="1">MSEPTGKYSITMPRDIAEAARSRSGHSGLSAYVAAAVARQIERDNLNELITVAEAEHGPITDEEIQALRDQLHQARQQQTSDGADAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8R0</accession>
    <name>A0A0F7N8R0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_22055</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
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        <lineage>
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        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
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        </subcellularLocation>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <location>
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            <end position="77"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="382"/>
        </location>
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        <location>
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            <end position="413"/>
        </location>
    </feature>
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            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH84431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="427" mass="44333" checksum="B99AB61D2AE98E98" modified="2015-07-22" version="1">MSTVTKTGVAAPAKQPPGDGGRRRLGMPQVLLLIAAGLLLLSAVRALTDTTNLTASAQIGGALALAVPIGLAGLGGLWAERSGVINIGLEGMMILGTFFAGWIGWQHGPWAGALAGIIGGALGGLVHAMATVTFGVDHIVSGVAINILALGATQYMAKIFFADGDALAAGGTDKQSPQVDDMHTFSVPGLSDGLGDLEDKHWFFLSDTAGILRGLTHDVSYLILIAAALFVLTYYVLWRSAFGLRLRSCGENPVAAESLGVNVYLYKYAALAVSGALAGLGGAFLVTFTHIYLEGQTGGRGYIGLASMIFGNWRPGGTAMAAGLFGFTDSLQLRGGGEAVHALFLLLAVLLAAYAVWKYVRGGARAAIAAGVAAVLLGVLYATTDTVPREVVEATPYVTTLVVLAVFAQRLRVPKWIGKRYRRGEST</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-10-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8S4</accession>
    <name>A0A0F7N8S4_9ACTN</name>
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    </gene>
    <organism evidence="1 2">
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        <lineage>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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                <person name="Winkler A."/>
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                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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    </dbReference>
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        <property type="gene ID" value="AA958_18775"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_18775"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3942"/>
    <dbReference type="OrthoDB" id="1526778at2"/>
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH83903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="159" mass="17520" checksum="198C78952728ADF2" modified="2015-07-22" version="1">MPWVTLASAVVGALIATVSAALLERSRWRREQDDRLISARRALYGEYLASLSQARNDFRGLARNRAMAPADRERSARDAFASCYDVRYQMSITAASNVVVASEEAFRRLRDVRDLAAAGTLAGDEAYSGGRAAYEAALSRLRDAMRFDLGSDREPALAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8V3</accession>
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                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AKH83844">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Lsr2"/>
    </dbReference>
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        <property type="entry name" value="Lsr2_dimerization"/>
    </dbReference>
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        <property type="entry name" value="Lsr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="105" mass="11309" checksum="7B329D9510F670B4" modified="2015-07-22" version="1">MAQRVVVSLFDDIDGGEATETVNFGLDGKSYEIDLNASNAKKLRSTLAPFLRAGRKQAASGRAFTRTDIAPNPATVRAWAGSQGMEVPARGRIPKKVYEAFEAAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N912</accession>
    <name>A0A0F7N912_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Puromycin resistance protein pur8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_14445</name>
    </gene>
    <organism evidence="8 9">
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        <lineage>
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    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83232.1"/>
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    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="SSF103473"/>
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        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
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            <begin position="1"/>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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        <source>
            <dbReference type="PROSITE" id="PS50850"/>
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        <source>
            <dbReference type="EMBL" id="AKH83232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="509" mass="52647" checksum="230D437166FD021C" modified="2015-07-22" version="1">MSRTDAVAGSGPAGETGPPAAAVMPQDDRAHRHRWLILAVLGLAQLMVVLDVTIVNIALPSAQSDLGFTNGDRQWVVTAYSLAFGSLLLLGGRIADLVGRKVTFLVGLVGFAAASAVAGAAVSFDMLILARAFQGASGALLAPSALSLLTTTFTDPGERAKAFSVYGAVSGAGGAIGLLLGGVLTEYLDWRWTLYVNVVLAVVAFGFASALLTRTARDRSVTLDVPGTVLVTAGLFCVVYGFSNAEHQDWGAPATWGLLIAGGVLLTAFAWWSTRSRHPLLPTRIVTDRNRGASYLGMLISAGGMFGVFLFLTYFLQTGLDYTPIDSGVAFLPMVGGLVIAATLATNVLVPRIGPRLVVPSGMAIAAAGLVWMTSLDLNSSYAADILPMTVIVGFGLGLVVATAMSLGTLGVSVHDAGVASATVNAMQQVGGSIGIALLNTVSASAATNYLSGRNPRDPAVKAQAALESYHTAFWWSAGFFAAGALVTLFLYRRGAPKELKGGAPTIHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N983</accession>
    <name>A0A0F7N983_9ACTN</name>
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        <recommendedName>
            <fullName evidence="3">Signal peptidase I</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_25960</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.</text>
            <dbReference type="EC" id="3.4.21.89"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the peptidase S26 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.89" evidence="3"/>
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        <property type="protein sequence ID" value="AKH85095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="444103.AA958_25960"/>
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        <property type="protein sequence ID" value="AKH85095"/>
        <property type="gene ID" value="AA958_25960"/>
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        <property type="component" value="Chromosome"/>
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    </dbReference>
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        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000223">
        <property type="entry name" value="Pept_S26A_signal_pept_1"/>
    </dbReference>
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        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
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        <property type="entry name" value="PTHR43390"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LEADERPTASE"/>
    </dbReference>
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        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="sigpep_I_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
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        <location>
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            <end position="216"/>
        </location>
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    <feature type="domain" description="Peptidase_S26" evidence="4">
        <location>
            <begin position="15"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="34"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR600223-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH85095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="241" mass="24860" checksum="E8BF729EF9078E65" modified="2015-07-22" version="1">MLSGLAVAVGCVLFLGGFAWGAAVYVPYTVPTSSMAPTVASGDRVLAERISGDEVRRGDVVVFEDAAWGDLPMVKRVVAVGGDTVRCCDAQGRLTVDDVPVAERYVTESQRAAQEDFPATTVPEGMVFLLGDHRGDSVDSRSHLAESGGGAIPRDAVRSRVDATAWPLGSAGMLERPDGFAALPGGISEPGPLGPLLLAVVAGAALILGGAAYGPVSGYARARRARGTHNGVTHRRKGNVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9B1</accession>
    <name>A0A0F7N9B1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Potassium-transporting ATPase potassium-binding subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP phosphohydrolase [potassium-transporting] A chain</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Potassium-binding and translocating subunit A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Potassium-translocating ATPase A chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">kdpA</name>
        <name evidence="10" type="ORF">AA958_15120</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds the extracellular potassium ions and delivers the ions to the membrane domain of KdpB through an intramembrane tunnel.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">The system is composed of three essential subunits: KdpA, KdpB and KdpC.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the KdpA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016641.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_15120"/>
    <dbReference type="EnsemblBacteria" id="AKH83327">
        <property type="protein sequence ID" value="AKH83327"/>
        <property type="gene ID" value="AA958_15120"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_15120"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3186"/>
    <dbReference type="OrthoDB" id="296671at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008556">
        <property type="term" value="F:P-type potassium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00275">
        <property type="entry name" value="KdpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004623">
        <property type="entry name" value="KdpA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30607">
        <property type="entry name" value="PTHR30607"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03814">
        <property type="entry name" value="KdpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001294">
        <property type="entry name" value="K_ATPaseA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00680">
        <property type="entry name" value="kdpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0630">Potassium</keyword>
    <keyword evidence="3 9" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="130"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="279"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="376"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="414"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="480"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="522"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AKH83327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="554" mass="57024" checksum="3584DFFBAF85082D" modified="2015-07-22" version="1">MSPILADVLQVSALVVALALVHRPLGDYMAGVYGGKKHSRVERWIYRTIGADPDAGMRWPAYLRAVLAFSLAGVLFLYLLQRVQDKLPLSLGFAAISPDQAFNTAASFVANTNWQSYSGESAMGHLTQTGGLAVQNFVSAAVGMAVAVALIRGFARSRTGELGNFWADLVRGTLRILLPMAAVAAVLLVACGAIQNFSGTESVTTVTGQTQHLTGGAVASQEAIKDLGTNGGGFYNANSSHPFENPTGISNLLEIFLLLVIPFALPRTFGRMVGSVRQGYAVVAAMAGIWLAGVITVTALEAAHPGAAAQVAGGAMEGKEQRFGEGASSLFAVSTTMTSTGSVNSFHDSFGGLSGGVLLFGMMIGEIAPGGVGSGLYGMLVMAIVAVFIAGLMVGRTPEYLGKKIGPREMKLAACYILVTPALVLTGTALAMGTGNGESSMTNTGPHGFSEVLYAYTSASHNNGSAFAGFSANTGFHNTALGLCMLLGRFLPMVFVLALAGSLAGQRPVPATAGTLRTDKPLFTGVLVACIAIVAGLTFFPSLALGPLAEGLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9G8</accession>
    <name>A0A0F7N9G8_9ACTN</name>
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        <submittedName>
            <fullName evidence="5">LuxR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_26505</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_26505"/>
    <dbReference type="EnsemblBacteria" id="AKH85190">
        <property type="protein sequence ID" value="AKH85190"/>
        <property type="gene ID" value="AA958_26505"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_26505"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5578"/>
    <dbReference type="OrthoDB" id="930905at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="2"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="144"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH85190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="217" mass="23816" checksum="57452F1393153FB8" modified="2015-07-22" version="1">MRVVLAEDQYLLRDGLTRLLQAHGMEICAAVESGDELLAALRAERPDVAVVDIRLPPTFTDEGLQAALAARRERPDLPVLILSQHVEQLYARELLADGRGAVGYLLKDRVFAARQFVDSVRRVAEGGTAMDPEVIAKLLASNARDEPLGRLTPREREVLAGMAEGRSNTAIARQLFLSEGAVSKYTTSIFAKLDLPPSDDDNRRVRAVLAYLNGQVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9L0</accession>
    <name>A0A0F7N9L0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_15540</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016699.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_15540"/>
    <dbReference type="EnsemblBacteria" id="AKH83387">
        <property type="protein sequence ID" value="AKH83387"/>
        <property type="gene ID" value="AA958_15540"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_15540"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3271"/>
    <dbReference type="OrthoDB" id="1020672at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="2"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="124"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="124"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH83387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="228" mass="24601" checksum="C1FAA0A2507AD0E9" modified="2015-07-22" version="1">MRLLIVEDERRLATSLARGLAAEGFAVDVVHDGVEGLHRATETDYDLIVLDIMLPGLNGYRVCAALRAAGDETPILMLTAKDGEYDEAEGLDTGADDYLTKPFSYVVLLARVRALLRRRGRTAAPVLRVGALAVDPAARRVHAGDTEVTLTTKEFAVLEVLAQRAGEVVAKSEILDHAWDFAYDGDPNIVEVYVSALRRKLGARTIQTVRGAGYRLADPDTAGGSARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9P8</accession>
    <name>A0A0F7N9P8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HATPase_c domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_24000</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018018.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_24000"/>
    <dbReference type="EnsemblBacteria" id="AKH84766">
        <property type="protein sequence ID" value="AKH84766"/>
        <property type="gene ID" value="AA958_24000"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_24000"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5058"/>
    <dbReference type="OrthoDB" id="811938at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="3">
        <location>
            <begin position="261"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="467"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="724"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="500"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH84766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="753" mass="73659" checksum="A9E558E62F5A9786" modified="2015-07-22" version="1">MRTPVQPDRQEGRGAGRRRGAHPAPRTSPRAKAAYLVVGAAVLAAGAPGLVGALRGVSGADPEERAQAASALQVHGALLALCAVLAVGVVVYAARGMQAADGADTEDAAEKAAELAAVRAELAAARENHVVERDSLLRERAALAERIGGLQASVQGTFVGLSRRTLGLVERQLSFIDELEAHEQEPGTLETLFRLDHLAACMRRHSENLLVLAGADHRGTRRANVPLIDVLRAAVGEIESYQRVVLSPDVPQVHVTGFASGDASHLLAELLENATSCSPPESEVLLTGRLLGTGDLLLVVRDEGIGISPAARVDDLNARLADTDPGPAPREALGLGLYVVARLAARHGVGVELRLRDRGVDAEVRLPGRLLVGGAADGTDDDAGLAGASAAVGGDAAGFAGAGAAGGGAGPGGGAAGLAGVGAAGGGAGFAGSAAGAVGVAGSVGAGGVAGGGGAAAAGGAGRAVPVPAARGARPEPGPRTDAESRGVRDGGAAPVRVGPQRSGPPPDGGVRPAPPPFASARPAAAPRTGGWVRAEAGMLPRRRPGGTVSGGAVAPPRHGTATGTPVPAGAGAAAGAAVPGEAPARAVPARPAPAREAPAHAAAGQPAPVTASAGHPPAEHLATGQAAPGHPAFEHPAPGHPAVLHPAPGHPATGPAALSPVPAGRAAAPGPAAGAPPARAVAPQRGAESPGGWPAAPVRAVVAVPAQAARRGADAREVRRLLGGLQQGSRDGRRAAAAEAATWDAKEQGAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9T9</accession>
    <name>A0A0F7N9T9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_21095</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017553.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_21095"/>
    <dbReference type="EnsemblBacteria" id="AKH84273">
        <property type="protein sequence ID" value="AKH84273"/>
        <property type="gene ID" value="AA958_21095"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_21095"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4442"/>
    <dbReference type="OrthoDB" id="1120891at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519213" evidence="2">
        <location>
            <begin position="30"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH84273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="362" mass="37915" checksum="7239E595A6D9173C" modified="2015-07-22" version="1">MSALKFARAALAGALLVAAVTSSSFVAHAEGEIGNGTGNVEEPPSGPGGGAEGQNLYAEAGGVVFDESENGGGGGSGGSGGGGALEPVGDWAPPPCWYAPLYTPRQLKKEMEHTWSLESTGYQWDAEQRAKYSQGGDKPGTYEDFNMAKSGDGYWWDGYVPDGGAGVPRALDCDDGPFWVDEGDPPPAEYQDAVTPQILSEIAYNRIRVPDTEINLKPDAENAQKVNLPTWAWLDAATFEPVSVTAEVPVLGIWARTTATPVSLTLDPGTADAELHPSSGTCPINDDGSIGTPYTAGSAEETPPCGLTYLRATPDGETYTFRATINWSIEWEGSGDTGGDLPDGSFGATTELEVDEIQSVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-10-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NA67</accession>
    <name>A0A0F7NA67_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_21810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017655.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH84393">
        <property type="protein sequence ID" value="AKH84393"/>
        <property type="gene ID" value="AA958_21810"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_21810"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4593"/>
    <dbReference type="OrthoDB" id="1577144at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="259" mass="28435" checksum="06ACFFCC87D81FF4" modified="2015-07-22" version="1">MGWIRDRLFGGRAGRGRGGTAPPRGDGDGGGSGGGGAGRGGDDLVCDCCNAAVARADAYYLPTRTVMISEAHWADCFATNKAVWEMFLPEDRLPSVFDDFLRQHVSSNTPWAVCERCSEFFIFDRAAARADALNDHISDDNGAVDPAGCVLFAALGWERVHGSWPESVKKPEVADVCDFCEKKMYVGEMWGFAAEETLARYEANGFTDHDRPVRVARTNEEGKTGWVECQVCLARNLNRGQRADYRPEGRDWRDSPGTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAC6</accession>
    <name>A0A0F7NAC6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zn-dependent hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_28330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018734.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_28330"/>
    <dbReference type="EnsemblBacteria" id="AKH85500">
        <property type="protein sequence ID" value="AKH85500"/>
        <property type="gene ID" value="AA958_28330"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_28330"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5971"/>
    <dbReference type="OrthoDB" id="767622at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="20"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="249" mass="25473" checksum="E79F0376AE88F351" modified="2015-07-22" version="1">MTILHYVGGPTALLHLGGVRLLTDPTFDPPGEYPVGGRRLVKTAGPAIAPAGLGPVDAVLLSHDQHPDNLDRAGRECAAAAPLVLSTASAAERLRGPVRALPAWESYAVGPVRVTAVPAQHGPPGTGHLTGEVTGFVLTGDGLPTVYVSGDNASLDVVRTIAARLGPVDIAVLFAGAAQTPLLGAAHLTLTSEHAAAAAAVLGAHDVVPLHFEHWEHFTQGADSLVAAFEAAGLGHRLRLPRPGEAVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAC7</accession>
    <name>A0A0F7NAC7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_17250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016971.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_17250"/>
    <dbReference type="EnsemblBacteria" id="AKH83667">
        <property type="protein sequence ID" value="AKH83667"/>
        <property type="gene ID" value="AA958_17250"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_17250"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3627"/>
    <dbReference type="OrthoDB" id="785625at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH83667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="336" mass="37569" checksum="C03C9F345BA9D53A" modified="2015-07-22" version="1">MTYDTGFVVRGQMSREHFDPAVVRRELAIIRDDLHCNAVQIIGGDPGRLELAAAAAAELGLEVWFSPYPLELDPEQILVLFRDCAERSERLRRQGAAVVFVAGVELSVMNRGFLPGESPEERVEQLMSQPERRAGAMRELGVRINAFLREAAATVRERFQGKLTYASIQFEQVDWTPFDIVTFELIRSAEVADRFRDAVRTLAQGPKPLALTGFGTAAYRGAGDRGGRVLEVVEHDPETRAPVRLNGIYERDEAGQAAYLSELLEIFDTEGVDSAFVFLFALPGYPHRPDGDPRDDLDRAGLGIVKLLEGRRGQTYPDMDWEPKAAFTAVAQRYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAD5</accession>
    <name>A0A0F7NAD5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ornithine aminotransferase</fullName>
            <ecNumber evidence="3">2.6.1.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Ornithine--oxo-acid aminotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rocD</name>
        <name evidence="7" type="ORF">AA958_21855</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-ornithine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.13" evidence="3"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017661.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_21855"/>
    <dbReference type="EnsemblBacteria" id="AKH84399">
        <property type="protein sequence ID" value="AKH84399"/>
        <property type="gene ID" value="AA958_21855"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_21855"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4602"/>
    <dbReference type="OrthoDB" id="572533at2"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00358"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050155">
        <property type="term" value="F:ornithine(lysine) transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004587">
        <property type="term" value="F:ornithine-oxo-acid transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010164">
        <property type="entry name" value="Orn_aminotrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986:SF18">
        <property type="entry name" value="PTHR11986:SF18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01885">
        <property type="entry name" value="Orn_aminotrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH84399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="401" mass="42644" checksum="C6811DB83BCC552A" modified="2015-07-22" version="1">MTRTDAAIAAADAHSAHNYHPLPVVVATAEGAWMTDVEGNRYLDMLAGYSALNFGHGNSRLLDAARAQLDRVTLTSRAFHHDRFAEFCAQLAELCGKDMVLPMNTGAEAVETAVKTARKWGYRVKGVPEGRAKIVVAENNFHGRTTTIVSFSTDPEARADYGPYTPGFAIVPYGDLAALDAAVDEDTVAVLLEPIQGEAGVLVPPPGYLAGVRELTAARNVLFMADEIQSGLGRTGRTFACEHEGVVPDVYILGKALGGGVVPVSAVVASREILGVFHPGEHGSTFGGNPLACAVGLEVIAMLRTGEYQQRATELGDHLHRELGLLTGTGAVREVRGRGLWAGVDIDPAHGTGRQLSEKLMARGVLVKDTHGSTIRIAPPLVISKEDLDWGLTQLRETLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAV6</accession>
    <name>A0A0F7NAV6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_22880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017831.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH84574">
        <property type="protein sequence ID" value="AKH84574"/>
        <property type="gene ID" value="AA958_22880"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_22880"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4819"/>
    <dbReference type="OrthoDB" id="1629652at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025683">
        <property type="entry name" value="Protein_beta"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14350">
        <property type="entry name" value="Beta_protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH84574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="348" mass="37882" checksum="A4AEC58FDBE6B81E" modified="2015-07-22" version="1">MPGPLYIPVLPVRAHAASAFGKLDAETADRTVPLWTLPEIGGGARQPADTVKKALRRIVRVQQRRAAWLDTPFTALDHDPYEELLRYCWSATPLLPVADPARPRSHQALAAECAAAAGGGLGVRIRVPGAFRDELTAHTQDLLVRVGVGVPVDLLLDLQAVLPTRPDAAKEAIRALDELVPLAAWRTVALLSGGFPDEAGRVLDRGRGVAARTDWHTWCELRTSERSYARSVRYGDYGTLAARNLTRPVEGSERSRYGLLRYTTERAFLLASFLVEGRGETGATRAAARWVTESSGYRGTRTSEGDRWYAECALTTGAAGTGNPTTWNTMGNIQHMTFVVQSLSRGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAV9</accession>
    <name>A0A0F7NAV9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_23315</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017904.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_23315"/>
    <dbReference type="EnsemblBacteria" id="AKH84648">
        <property type="protein sequence ID" value="AKH84648"/>
        <property type="gene ID" value="AA958_23315"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_23315"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4915"/>
    <dbReference type="OrthoDB" id="1401346at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH84648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="239" mass="25089" checksum="AEADD92E16CA5364" modified="2015-07-22" version="1">MVAFAVSATVLAGCAEDGPEAGENGVGKLAPESIRAKAEKAAAGASSVRLAGTLVSNGQPVKLDMRLSAAGGIGEVSTGGMTFSLLRAEEDLFLKAGDEFWLHQDDGEDGDGKPSESDMAAARKLDGKYVKVPPEDTAYKQLSGFTEMKVLLDGLLKLDGELAAEKNGEVDGFTTIRVTADEGVGGALEVALEGRPYPLLLERAGDAGELRLLNWDEEFEVNAPRKEEVVDYGKQISAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NB01</accession>
    <name>A0A0F7NB01_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_23185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017881.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_23185"/>
    <dbReference type="EnsemblBacteria" id="AKH84624">
        <property type="protein sequence ID" value="AKH84624"/>
        <property type="gene ID" value="AA958_23185"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_23185"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4888"/>
    <dbReference type="OrthoDB" id="2089156at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="64" mass="6705" checksum="7B6B52EB1118EBDB" modified="2015-07-22" version="1">MALSISLVLLLAIIVYLLIKKSGLKGGHAVVCILLGFYLASSSMAPTIDDVTQNVAGMIESIDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NB25</accession>
    <name>A0A0F7NB25_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_29650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018934.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH85705">
        <property type="protein sequence ID" value="AKH85705"/>
        <property type="gene ID" value="AA958_29650"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_29650"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6259"/>
    <dbReference type="OrthoDB" id="663556at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519449" evidence="1">
        <location>
            <begin position="33"/>
            <end position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="620" mass="66714" checksum="D51CC3571E8F360A" modified="2015-07-22" version="1">MTSGFPLSRRALITAAGAAGLAAAMPAPHALAAGTLPTLPALPPGSPSRRAFAAGEQLYAPYLVSLAPMANDVEDDGFMGGGWWRSPAAPYNTRVQEHVYTLSWFLTQNRSWNPYRGDSALLARLDAALGHYLGLQHSDGSWPEYSAGEHSLAATGFALGYLSKTHVLLKDAGLLPGRRSQIARALHGAMTWLLDPSNTRAWQAPIRYTNQVTAGLAGAALALRTNPDGTLRSRLNDAFARMAGNGQGPAGFFYEEGGMDMNYNFEVMLPEMADAWRQSHNGHLVTMARTYTDWLGYNLLREPDGSGWFCNIAPSSRTSTLAYDDTRPDPERTALNNQFVPLVPALGAFMSAREDLASARDAWAADPSPVAGLTKQNTSPRILTHAMYDEEYPTRSAKTRAIKAVPYLASTNFTEHRTDQGQDFLYVRRPGVYLGAYLGARPTSRARTGLSFLWHPVAGTVIQSLNDNNHGVWATVLPGQAPDSNGPQAGQFFGGSPYAFRFGTPSGSVVTDVEVGNGLVRRSVRANSAATETVPLILRASDRVVFTDGTVLSWGGSASATATGIDVHRNSGVVRIRWGAARNASIAAASLVYLRDGSRRMHILKVPHDGSLDVGIRLAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBC6</accession>
    <name>A0A0F7NBC6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GCN5 family acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_30375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019038.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH85810">
        <property type="protein sequence ID" value="AKH85810"/>
        <property type="gene ID" value="AA958_30375"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_30375"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6417"/>
    <dbReference type="OrthoDB" id="1389691at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="134" mass="14710" checksum="AFF11ABCD49FBB30" modified="2015-07-22" version="1">MHWKTERVAGASLDLDEVLAVYRDSGLGERRPVDDRERMATMVREANLVVVARDEDGALIGLARSVSDFAYVTYLSDIAVVRAHQRAGVGRALIDATMAEAPAAKLVLLSAPAARDYYPHLGFTRHDSAWVRST</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBH2</accession>
    <name>A0A0F7NBH2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Small ribosomal subunit biogenesis GTPase RsgA</fullName>
            <ecNumber evidence="3">3.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rsgA</name>
        <name evidence="7" type="ORF">AA958_28180</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="3"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018705.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_28180"/>
    <dbReference type="EnsemblBacteria" id="AKH85471">
        <property type="protein sequence ID" value="AKH85471"/>
        <property type="gene ID" value="AA958_28180"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_28180"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5940"/>
    <dbReference type="OrthoDB" id="908180at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01854">
        <property type="entry name" value="YjeQ_EngC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01820">
        <property type="entry name" value="GTPase_RsgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004881">
        <property type="entry name" value="Ribosome_biogen_GTPase_RsgA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010914">
        <property type="entry name" value="RsgA_GTPase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32120">
        <property type="entry name" value="PTHR32120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03193">
        <property type="entry name" value="RsgA_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00157">
        <property type="entry name" value="TIGR00157"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50936">
        <property type="entry name" value="ENGC_GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CP-type G" evidence="6">
        <location>
            <begin position="110"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="ENGC_GTPASE" evidence="5">
        <location>
            <begin position="119"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="349"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="162"/>
            <end position="165"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="216"/>
            <end position="224"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH85471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="372" mass="39030" checksum="A06D581557DC5AC1" modified="2015-07-22" version="1">MTHLPAPHRLIAYGWDEAAADAFAPYESEGLIPARIARVDRGSCIALTEAGPVRATTARLAAADRAAGRTADLTRLPCTGDWAALEPGERFAVQALLPRRTAFLRSASSKRSEGQVIAANVDHAVIAVSLAAASAADIEPARLERLLSLAWSSGAQPLVVLTKADLVADPVVLGHLVADVGELAPGTAALAVSAATGAGVPQVAAALSTGTSVLLGASGAGKSTLANALLGEDTQRVHEVRDADGKGRHTTVARDLLPLPGGGVLIDTPGLRGVGLWEADDGLGQVFAEIEELAARCRFPDCTHTAEPGCAVLAALEDGELHPRRLESYRKLQRENARIAARTDLRVQADRRRDWKRRDAAEREARARKGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBM6</accession>
    <name>A0A0F7NBM6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_30825</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019108.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH85880">
        <property type="protein sequence ID" value="AKH85880"/>
        <property type="gene ID" value="AA958_30825"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_30825"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6515"/>
    <dbReference type="OrthoDB" id="2117341at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH85880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="449" mass="49264" checksum="774DB304A652225E" modified="2015-07-22" version="1">MADDVGELIERLALWRTGDGGYNEVSLRERAIVALQERGPEVVPVLVDRLDALLADHAAHLERVAAVTAVWDAWYEEGDALVDEHGVGKVFELERYRTVPSDSLPQREPRDEHYQDPYDLKQGLVEALRRIGDDRAAPVYGRALRDRACIRYAATALRGTHLDGAVPALLDAAASIEPDDMAFPEVLRTLEHYGATTAQVRARFEAESGPRARVSLMHVMRKLPGDGSGRPADEEIADALVFLAMSRSATDRHGALRELKALGTLDALPGDAVDAHGSWDAAPGGAVMEAPPPAEAVHAAIVLAAHGNPPGHDGELRRRLRHMAEDAPAAARAVTAVLAREPRAPDAELELALRLALRLHPDRVAEHLPLLRALHGLTSYPAGRAGALRALRRDGMLFVLMLHEDAVLREEARAVFEDVAEPADRERFAEYEALRMGTWGRLVRRFKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBZ2</accession>
    <name>A0A0F7NBZ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_31425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019208.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH85980">
        <property type="protein sequence ID" value="AKH85980"/>
        <property type="gene ID" value="AA958_31425"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_31425"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6640"/>
    <dbReference type="OrthoDB" id="1339160at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="12"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="296" mass="30592" checksum="0D747AF8D2229C2D" modified="2015-07-22" version="1">MTAGATAPAPPVRVGLAGAGPWARAMHARMLAAGPETELTAVWARRPEAAAEAAAPYGAAVAGSFAELLDGCEAVAFAVPPAVQAELAVRAAAAGRALLLEKPLGPDLGAARAVAAAVAEHGVVSQLVLTKRYHPATRDFLRRAAAADVTGARSCYLHGAFLGGEFATAWRLEHGALLDLGPHLLDLLDAAVGPVAAVRGTGDPRRWIELTCEHENGAVSQASLSGSVRLPAARTRVELLGPGDELVYDTAGLDHEECWPVLRREFAAAVRAGRPGGLDARRGLLLQELLHQALPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NC08</accession>
    <name>A0A0F7NC08_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD-dependent dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_20840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017517.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_20840"/>
    <dbReference type="EnsemblBacteria" id="AKH84232">
        <property type="protein sequence ID" value="AKH84232"/>
        <property type="gene ID" value="AA958_20840"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_20840"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4393"/>
    <dbReference type="OrthoDB" id="948454at2"/>
    <dbReference type="Proteomes" id="UP000034283">
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    </dbReference>
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        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="7"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="221" mass="22467" checksum="52673CB6A2EC8698" modified="2015-07-22" version="1">MRIVIAGGHGQIALRLERLLAARGDEVAGIIRRPEHADDLRAAGAEPLVCDLESAGADEVARLLEGADAAVFAAGAGPGSGEARKDTVDRGAAVLFADAAVAAGVRRFLVVSSMGAGSEPPAGGDPVFSAYLRAKTAADEYVQARDGLDWTILRPGSLRNDAGTGLVDLAAKTGRSAVPRDDVAAVLVALLDEPRTVGLTLELVEGSTPVLDAVAAVAAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCS3</accession>
    <name>A0A0F7NCS3_9ACTN</name>
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        <submittedName>
            <fullName evidence="7">Amino acid permease</fullName>
        </submittedName>
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    <gene>
        <name evidence="7" type="ORF">AA958_31540</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019229.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_31540"/>
    <dbReference type="EnsemblBacteria" id="AKH86001">
        <property type="protein sequence ID" value="AKH86001"/>
        <property type="gene ID" value="AA958_31540"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_31540"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6662"/>
    <dbReference type="OrthoDB" id="527053at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amoino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
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    </dbReference>
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    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
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    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="265"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="317"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="365"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="391"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="433"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="461"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH86001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="507" mass="54270" checksum="5E384F882D58EF80" modified="2015-07-22" version="1">MSRAPVSAAGTSRRKDDDAHLRDLGYEPELARRMGPFGNFAISFSVISILSGCMTLYGFGLNAGGPAVMMWGWVAVGLFVLCVGMGLAEVTSAYPTSGALYYMAHQLGGPRWGWYTGWLNLLGLLGAIAGIDYGCALFIGAFLNLQWGFEPTAEKTLLIFAVILVLHMTLNLLRVRVVSILNSISVWWHLAGVAVIVGVLVVVPDHHQSAGFVFGEFNNDTGWNNPFYVTAIGLLLAQYTFSGYDASAHLSEETTQAQVSSAKGIVRAIWVSWVAGFVLLAGLTFAIQDYVGTQESSTGVPPAQIFIDAIGEGGAKALLLIVICAQLFCGNAETAATARMVFAFSRDGALPGSKMWRRVSPRTGVPTRAVMLSVAVAFCLALPSLYSATAYGAVTAINVIGITPAYAIPIYLRLRAKNRFVPGPWNLGKWSSLIGWIAVCWVAVITVIFCLPQASPVTVDTFNYASVALAAVLLLATVSWWAAGRRSYKTPVYAADPEMAELGKDLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCS6</accession>
    <name>A0A0F7NCS6_9ACTN</name>
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        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="2 3">
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        <lineage>
            <taxon>Bacteria</taxon>
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        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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    </dbReference>
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AKH85178">
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        <property type="gene ID" value="AA958_26415"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_26415"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5561"/>
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    <dbReference type="Proteomes" id="UP000034283">
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    </dbReference>
    <dbReference type="GO" id="GO:0016021">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="188" mass="20489" checksum="794D735D9F7C78AF" modified="2015-07-22" version="1">MPLPFLTADRDFGDVAGDAPLPYADRDRWRRPYRPGPWRVLMAAIELLLASYLLFATVIMLLADSVTGALTCAGVAGGFILAALRLLRVGVWVSAHGLRQVHLLRTVTLAWDEVAAVRTVQQPVKWLGLPRTVQGQALLVVPGARRGRGGDAAPLRPLLTDSNADFLSRPEAFDRAADTVEAWATELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCX6</accession>
    <name>A0A0F7NCX6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glucose dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_27310</name>
    </gene>
    <organism evidence="4 5">
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_27310"/>
    <dbReference type="EnsemblBacteria" id="AKH85324">
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        <property type="gene ID" value="AA958_27310"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_27310"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5755"/>
    <dbReference type="OrthoDB" id="152835at2"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
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        <property type="entry name" value="Glc/Sorbosone_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011041">
        <property type="entry name" value="Quinoprot_gluc/sorb_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07995">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50952">
        <property type="entry name" value="SSF50952"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519957" evidence="2">
        <location>
            <begin position="33"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="GSDH" evidence="3">
        <location>
            <begin position="95"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH85324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="507" mass="54401" checksum="658742B3E934C691" modified="2015-07-22" version="1">MHPPTRRKRRLLAPALAAAVAATAFLTAPAEARTEPTAAPGATAGAAAPGDSLLPTPVPAKLGLVVEEYAQFPKSEPTPPPSDPRLMRHARINALTELPDGSGRKAVPDLNGKLYLVEDGAQPRTYLDVGAAFAPQFFSGQGLGQGFGYAAFHPDFARNGIFYTVHTELASTTGKEPDLTPQPNTGYHGIITEWTADDPAAGTFSGTRREVLRLGFNGRIHGIQQIAFNPTAREGSADYGKLYLAVGDGGTGVRTTEPQNLALPHGKLLRIDPRGSNSANGKYGVPADNPFADRPGALGEVFAYGFRDPHRFSWDTGGKHRLYLGHIGEHAIESIYEVRAGDNLGWSEREGPFVFDKNPADPCDAYQPLPPDDDQYGYTYPVAAYDHDPPADWNCTSDVGRAVSGGFVYRGDDLDKLRGTYLFGDLVDGRVFGTKTGEMRRGAEMATIHRLRLYDAATGNLVTAQDLAGDTRVDLRFGQDSAGELYLLAKANGKVWKVTGTRGPALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7ND19</accession>
    <name>A0A0F7ND19_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_33640</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019577.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_33640"/>
    <dbReference type="EnsemblBacteria" id="AKH86355">
        <property type="protein sequence ID" value="AKH86355"/>
        <property type="gene ID" value="AA958_33640"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_33640"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.7103"/>
    <dbReference type="OrthoDB" id="1035565at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
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        <property type="entry name" value="NADP_OxRdtase_dom"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="20"/>
            <end position="258"/>
        </location>
    </feature>
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        <location>
            <position position="51"/>
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        <location>
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        </location>
        <ligand>
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        </ligand>
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        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AKH86355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="276" mass="30651" checksum="0A32597BBB2A6CCD" modified="2015-07-22" version="1">MPSVPVRRLNDGTKLPALGLGTYPMDDAEAERAVATALETGYRLVDTALNYGNEKGTGRGIARSGVPRQDVVVTTKLPGRHHGYEETLASFEESRRRLGVGYVDLYLIHWPLPRVDLYTDSWRAMVKLREEDLVRSIGVSNFTVAQLDRLERETGVLPAVNQIELHPHFPQEELRSYHARKGIVTQSWSPLGRGTDVLRDASIARVAEAHGVTPAQAVLRWHTQLDAVPIPKSADPVRQRENLDVFGFELSAAEMAAVAGRPQRRVGGDPDAHEEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-10-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDA1</accession>
    <name>A0A0F7NDA1_9ACTN</name>
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    <organism evidence="1 2">
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        <lineage>
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            <taxon>Actinobacteria</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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    </dbReference>
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        <property type="gene ID" value="AA958_32885"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_32885"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6947"/>
    <dbReference type="Proteomes" id="UP000034283">
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH86221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="89" mass="9187" checksum="13152EBC8D4BE0CE" modified="2015-07-22" version="1">MNVTDIEMTGRPHLRYSPLAVALRGGLEGPLPAVVDEDASVHGSHALSFGGGFSARTTTMSTGRPSAAASALIRGSSTTYGAQWVLGRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDV9</accession>
    <name>A0A0F7NDV9_9ACTN</name>
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            <fullName evidence="2">AP endonuclease</fullName>
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        <lineage>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85593.1"/>
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    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_28865"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6082"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="22"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="333" mass="37667" checksum="07F5D756C85DFDF1" modified="2015-07-22" version="1">MPRNFTLFTGQWADLPLEEVCRLARDFGYDGLELACWGDHFEVDKALNEPGYLDGRHQLLEKYGLKCWAISNHLVGQAVCDHPIDERHQAILPARIWGDGEPEGVRQRAAAEIADTARAAAAFGVDTVVGFTGSSIWHLVAMFPPVPPHMIERGYQDFADRWNPILDVFDAEGVRFAHEVHPSEIAYDYWTTHRAMEAVGHRPAFGLNFDPSHFVWQDLDPVGFLWDFKDRIYHVDCKEARKRLDGRNGRLGSHLPWGDPRRGWDFVSAGHGDVPWEDVFRMLRSIDYAGPISVEWEDAGMDRLQGAPEALRSLKALDFEPPQTSFDAAFGGD</sequence>
</entry>
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    <accession>A0A0F7NE11</accession>
    <name>A0A0F7NE11_9ACTN</name>
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        <name evidence="2" type="ORF">AA958_01190</name>
    </gene>
    <organism evidence="2 3">
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        <lineage>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_01190"/>
    <dbReference type="EnsemblBacteria" id="AKH86476">
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        <property type="gene ID" value="AA958_01190"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_01190"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.261"/>
    <dbReference type="OrthoDB" id="1613081at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
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    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
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        <property type="entry name" value="SSF53335"/>
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    </dbReference>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="287" mass="29973" checksum="6743AA3EF65227F3" modified="2015-07-22" version="1">MEEPVPVVAAVDGGTARLLPDVDRPRAYLLTVEGAPQSYVDLDDATHLEFEYARRLAHVVDLGFPPGRPLDAVHLGGGALTLPRYVAATRPGSRQEVAESDRGVIALVAEHLPLPEDCGVTVRALDARAALERRPAAACDLVIADVYGGARVPAHVASLEFAGAAARALRPDGLYVANLADSAPFRFLGSQLATAAAVFPELCLIAEPSVLRGRRFGNILVVAAKHGAEAGRGLPLAELARRTAADPFPARVEYGPALRRLMAGAQPVGDADAVPSPEPPDGAFTIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NEK1</accession>
    <name>A0A0F7NEK1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Actinorhodin polyketide synthase acyl carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_30265</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_30265"/>
    <dbReference type="EnsemblBacteria" id="AKH85793">
        <property type="protein sequence ID" value="AKH85793"/>
        <property type="gene ID" value="AA958_30265"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_30265"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6394"/>
    <dbReference type="OrthoDB" id="1943389at2"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="2">
        <location>
            <begin position="5"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="1">
        <location>
            <position position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH85793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="91" mass="9756" checksum="5A52847E44E415C2" modified="2015-07-22" version="1">MTDKPFTLDDLKRVLLQAAGADESTDLDGDILDATFEVLGYESLALLETAGQIEREYGISLDDDALADDLTPRTLIDLVNGRLAAARATTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NEK7</accession>
    <name>A0A0F7NEK7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_12500</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019991.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_12500"/>
    <dbReference type="EnsemblBacteria" id="AKH86716">
        <property type="protein sequence ID" value="AKH86716"/>
        <property type="gene ID" value="AA958_12500"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_12500"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2626"/>
    <dbReference type="OrthoDB" id="1058434at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030296">
        <property type="entry name" value="MlaF/Mkl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43023:SF6">
        <property type="entry name" value="PTHR43023:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="5"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="262"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH86716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="339" mass="36402" checksum="BD22CCE14FE30F94" modified="2015-07-22" version="1">MGIEVVVDGLTKSFGRQNIWRDVTLTLPAGEVSVMLGPSGTGKTVFLKSLIGLLKPEEGQVLVDGVDMVNDRERDVFEARKKFGLMFQDGALFGSMSLFDNVAFPLREHTRKKESEIRRIVMERMDLVGLGGAEGKLPGEISGGMRKRAGLARALVLDPEIVLCDEPDSGLDPVRTAFISQLLIDVNAQIDATMLIVTHNIDIASTVPDNIGMLFRRNLVTFGPREVLLTSEEPVVSQFLSGSRLGPIGMSEEKDAATLTAEGPDAGAASGTGPREIVPQLEPSPGMPPRQAVERHRERVLGMLAQLPSAARKAIVAGIGGSVAHARTLTMPAPPEERP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NES0</accession>
    <name>A0A0F7NES0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA polymerase subunit sigma-24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_30555</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019066.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH85838">
        <property type="protein sequence ID" value="AKH85838"/>
        <property type="gene ID" value="AA958_30555"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_30555"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6457"/>
    <dbReference type="OrthoDB" id="1469807at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="5">
        <location>
            <begin position="20"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="6">
        <location>
            <begin position="111"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH85838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="410" mass="44152" checksum="901F1C4D3804AC4F" modified="2015-07-22" version="1">MSDEGVRDAVARAHRAEWARIVAALTRRFGDLDIAEEAAAEAFATAVERWPADGVPPGPGAWLTTTATRKAIDRIRRESKRDDKQREARMLHDDTPPEAVGAIDDDRLRLIFTCCHPALAPEARVALTLRLVGGLTVPEIARAFLVREPAMGQRITRAKAKIKAAGIPYRVPAAEDLPARVSGVLAVLYLVFNEGYLPTGPEAGPVRRDLTAEAIRLTRLVRTLLPADGEVAGLLALMLLTEARRPVRISAAGELVPLGAQDRGAWDAALVAEGHRLVRERLATGQAPGRYQILAAINAVHTSARDVRDTDWSQVVALYDQLVRIDPSPVVALNRAVAVAETDGPDVALAAVDRLADGLAGYHAFHATRADLLRRLGRGAAARAAYDRAIELAGNTAETAYLARRRGELG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NEU5</accession>
    <name>A0A0F7NEU5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_26815</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018484.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_26815"/>
    <dbReference type="EnsemblBacteria" id="AKH85247">
        <property type="protein sequence ID" value="AKH85247"/>
        <property type="gene ID" value="AA958_26815"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_26815"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5641"/>
    <dbReference type="OrthoDB" id="1074175at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="85"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="201"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="260"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="86"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH85247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="293" mass="31891" checksum="FA0F9146737E269A" modified="2015-07-22" version="1">MAEGQRTLISPAVLARPRGKALYWTAFALVMAVFTLVFIGPLYWMVTSGLKSSQEFAQTPPTLVPGEVQPENYSEAWSVLDLAQLLLNTCVYAFGALAFMLVFDVAAAYSLSKLRPVLGKVILGAMLATLMIPATVLVVPQYLTVLDVPLVERNLINSPWVIWLPAVTNAFNIFLLKRFFDSIPRELMDAAAMDGASPLRTLRSIVLPMSRPILGVVSIFAVVAVWKDFLWPMLTLPDPSKQTLNVGIYSLGASVPENQLIAALAIASVPTSVIFLVFQRNIMHGLTAGSLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NEW4</accession>
    <name>A0A0F7NEW4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_23370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020351.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86985">
        <property type="protein sequence ID" value="AKH86985"/>
        <property type="gene ID" value="AA958_23370"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_23370"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4927"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="95" mass="9694" checksum="367D839CB733FD56" modified="2015-07-22" version="1">MILAAVLSAVIGLAIALAALSRYPDRFRHRNLTLATGPGAAVLGAALAHTVLGAGNLPIVLPVAGAFSAAMLSLLVKNRERSRPAAAYLAGRPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NEW8</accession>
    <name>A0A0F7NEW8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_30885</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH85888">
        <property type="protein sequence ID" value="AKH85888"/>
        <property type="gene ID" value="AA958_30885"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_30885"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6527"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="2"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="134"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH85888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="273" mass="27646" checksum="26E21260A12F665C" modified="2015-07-22" version="1">MVSFSFSFPATVWALDGLGPWTATGVRGLLAGLLAAGCLAAARAPVPPRRDLAALLTVAVGCVLGFPLLTTLALQTSTTGHSAVVIGVLPLATAACSAALTGRRPSRTFWTAAGAGALAVLAFTLSQSRGLPGTGDLCLFGALLLCAAGYAQGGRLAGRMPGWQVIAWGCVAALPVTALVAALALPREPADLTGQSVAGLAYIAAVAQFGGFVLWYRGMAVIGVPRASQLQLAQPLLTLVWSVLLMGEHLAPLAPVTAVIVLACIAVTQRART</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NF13</accession>
    <name>A0A0F7NF13_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dihydrodipicolinate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_27300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DapA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018557.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_27300"/>
    <dbReference type="EnsemblBacteria" id="AKH85322">
        <property type="protein sequence ID" value="AKH85322"/>
        <property type="gene ID" value="AA958_27300"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_27300"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5753"/>
    <dbReference type="OrthoDB" id="1438588at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="PTHR12128"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR001365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="287" mass="29963" checksum="EE874D981B858C34" modified="2015-07-22" version="1">MVAAALPLRADLTVDFDAYAAHVRRLLDAGCDGVVTNGSLGEYQTLTDDERVRLVHTAVAAAGDGDRVMAGAAAYGSAEARGWTERAAEAGAGSVLLLPPTAYRADEAAVRAHYAEVAKAGLPVVAYNNPYDTRIDLTPALLAAMHGEESIVAVKEFTGDVRRAYEIAELAPGLDLLVGADDVLLELAVAGAVGWIAGFPNALPDACATLYRAATGGDLALAMPLYRALHPLLRWDSKPEFVQAIKLSMDVAGLHGGPCRPPRSPLTDEQAAVVRGVTEKLLAEGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NF83</accession>
    <name>A0A0F7NF83_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_30045</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_30045"/>
    <dbReference type="EnsemblBacteria" id="AKH87135">
        <property type="protein sequence ID" value="AKH87135"/>
        <property type="gene ID" value="AA958_30045"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_30045"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6344"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH87135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="349" mass="39207" checksum="3353EBB72EFD079B" modified="2015-07-22" version="1">MSRLPMVLAFPRVLRHLRSVGASLPPVTRLSVGRPDPVLRPVLSAAWEGDHGAARELLADTRRRREWERRDRCVAALADVALVRPRWLEVWLEKEGDDPDAALVSADLQIDRAWEARTSVRAKHVSRERFAEFFRILGEAAPVIERAAELNPGDPVPWRVALQHARGSQAPRPVFDRLLLNVMDSDPDHYPCHANALQFLCAKWYGSHEEMFDFAETAAARARPGRLLAALPVEAVTEYLTEHPLGRGPVPRQRVHAAVDRTLEVCAGYEPGDPAATGIRNHLALALTRCGRWEEALRQFELIGTDVRELPWAYVDGENEVRGFADARENTRVQVAKAVPFFSRYRPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFP2</accession>
    <name>A0A0F7NFP2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Methylated-DNA--protein-cysteine methyltransferase</fullName>
            <ecNumber evidence="7">2.1.1.63</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">6-O-methylguanine-DNA methyltransferase</fullName>
            <shortName evidence="7">MGMT</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">O-6-methylguanine-DNA-alkyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AA958_28595</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>a 4-O-methyl-thymidine in DNA + L-cysteinyl-[protein] = a thymidine in DNA + S-methyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:53428"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:13555"/>
            <dbReference type="Rhea" id="RHEA-COMP:13556"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:137386"/>
            <dbReference type="ChEBI" id="CHEBI:137387"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 7">
            <text>a 6-O-methyl-2'-deoxyguanosine in DNA + L-cysteinyl-[protein] = a 2'-deoxyguanosine in DNA + S-methyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:24000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:11367"/>
            <dbReference type="Rhea" id="RHEA-COMP:11368"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:85445"/>
            <dbReference type="ChEBI" id="CHEBI:85448"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="7">This enzyme catalyzes only one turnover and therefore is not strictly catalytic. According to one definition, an enzyme is a biocatalyst that acts repeatedly and over many reaction cycles.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the MGMT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.63" evidence="7"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018781.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_28595"/>
    <dbReference type="EnsemblBacteria" id="AKH85547">
        <property type="protein sequence ID" value="AKH85547"/>
        <property type="gene ID" value="AA958_28595"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_28595"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6024"/>
    <dbReference type="OrthoDB" id="1327994at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003908">
        <property type="term" value="F:methylated-DNA-[protein]-cysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA dealkylation involved in DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06445">
        <property type="entry name" value="ATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00772">
        <property type="entry name" value="OGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001497">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014048">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036217">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNAb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008332">
        <property type="entry name" value="MethylG_MeTrfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023546">
        <property type="entry name" value="MGMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036631">
        <property type="entry name" value="MGMT_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01035">
        <property type="entry name" value="DNA_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Methyltransf_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF46767"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ogt"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MGMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 7 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_1N" evidence="9">
        <location>
            <begin position="5"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="DNA_binding_1" evidence="8">
        <location>
            <begin position="79"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; methyl group acceptor" evidence="7">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AKH85547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="161" mass="17299" checksum="2A26476FC55BF61B" modified="2015-07-22" version="1">MRTHTTLDSPVGPLTLVAEDDSLTGLYMTDQRHRPAEETFGTPADPGDPPFAAAAAQLTAYFAGERTDFDLPLHLAGTPFQQRVWEQLRQIPYGETISYGELAERVGNPAASRAVGMANGRNPVGIIVPCHRVVGANGSLTGYGGGIDRKKQLLALERREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFX1</accession>
    <name>A0A0F7NFX1_9ACTN</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_32900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86223">
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        <property type="gene ID" value="AA958_32900"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_32900"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6951"/>
    <dbReference type="OrthoDB" id="2103216at2"/>
    <dbReference type="Proteomes" id="UP000034283">
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    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="145" mass="15719" checksum="71E26B879D58900B" modified="2015-07-22" version="1">MRQLSAVAAVGLVLACPVWVWWVIGPLDADFDDLDYYIRPPDLPPGLEPALGITGIAVAVVCGLVLLVATCLEWFDWRWWQVIGPLVLAGIGTGYGWRILTAGGIGANIGAGFVMFFGVPALVATLVWALVRSVLLVRQEHRHRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NG77</accession>
    <name>A0A0F7NG77_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Beta-lactamase2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_33495</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_33495"/>
    <dbReference type="EnsemblBacteria" id="AKH86328">
        <property type="protein sequence ID" value="AKH86328"/>
        <property type="gene ID" value="AA958_33495"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_33495"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.7074"/>
    <dbReference type="OrthoDB" id="1158151at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008800">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030655">
        <property type="term" value="P:beta-lactam antibiotic catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13354">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002520068" description="Beta-lactamase2 domain-containing protein" evidence="1">
        <location>
            <begin position="39"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase2" evidence="2">
        <location>
            <begin position="133"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH86328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="301" mass="30648" checksum="B59DD834B01CD73D" modified="2015-07-22" version="1">MSRNLPTLRAAAVAAGTFALIAATASSSAPLVGDAAEAAGASRTRYVQYAPATGKAPASAPSADQAVTKALKALPKPAGAYDLAVADLDSGARAAHASGKGSFDTASIVKVDILAALLLQAQDDGGTLTGAQKKLAAEMIRSSDNDATDALWSDIGGGSGLADANRRLGLTETEPGDGGTWGLTQTTASDQLALLEAVYGDDRSPLNGDSRHYVEKLMASVVDDQRWGVSAAADDAGEAALKNGWLPRSATGLWDINSIGRVEHRGHTLLVAVLSDGHDSHEAGVDAVETYTTTAANALRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NG99</accession>
    <name>A0A0F7NG99_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_30140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019000.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_30140"/>
    <dbReference type="EnsemblBacteria" id="AKH85772">
        <property type="protein sequence ID" value="AKH85772"/>
        <property type="gene ID" value="AA958_30140"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_30140"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6365"/>
    <dbReference type="OrthoDB" id="1167152at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH85772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="264" mass="27444" checksum="89B28F966ED31645" modified="2015-07-22" version="1">MPAASGEPAFTHPARLGSRLDGLHAVVFDTDGVIIDSARIHAAAWQLAFDAALRARPPADPALRGPFDPVEDYRRHVDGKSRIDGAKDFLAARGLALPLGGPADPPGTGSVWGVAAAKERAFTACLAEHGVAAFPGSVHLLDRLRRAGLPCAAVSASRHARDLLLRAGVGDYFTCLVDGADSARLGLKGKPAPDLFLEAARRLGTEPRDAAVVEDALAGVEAGRAGDFALVVGVDRTGTGPSAADLKRRGAHLVIRDLTELLDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NGE2</accession>
    <name>A0A0F7NGE2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADH-quinone oxidoreductase subunit J</fullName>
            <ecNumber evidence="1">7.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_30455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I subunit 6 family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019050.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_30455"/>
    <dbReference type="EnsemblBacteria" id="AKH85822">
        <property type="protein sequence ID" value="AKH85822"/>
        <property type="gene ID" value="AA958_30455"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_30455"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6436"/>
    <dbReference type="OrthoDB" id="1975179at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001457">
        <property type="entry name" value="NADH_UbQ/plastoQ_OxRdtase_su6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042106">
        <property type="entry name" value="Nuo/plastoQ_OxRdtase_6_NuoJ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00499">
        <property type="entry name" value="Oxidored_q3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0520">NAD</keyword>
    <keyword evidence="1" id="KW-0874">Quinone</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="187" mass="20086" checksum="94B497E68DE0A55C" modified="2015-07-22" version="1">MPDDAVFWVLAVTALASGAMVFRFDSMARATYALLLSLLCVGGLVLRLGLDYLGVVVILMMTIEMSIMALFMVMFMMNPAGLLPMSMLHNKRGAAAVSAAVFVLLAAGILLAPWPGRRGKPDDDPTMALGESLMGPHMLTMMTLGLALFATIVATVVLATGRGRYDRFGDDLRARRPADPVRPGARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NHI9</accession>
    <name>A0A0F7NHI9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ornithine decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_32835</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Orn/Lys/Arg decarboxylase class-I family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019439.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_32835"/>
    <dbReference type="EnsemblBacteria" id="AKH86212">
        <property type="protein sequence ID" value="AKH86212"/>
        <property type="gene ID" value="AA958_32835"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_32835"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6937"/>
    <dbReference type="OrthoDB" id="485164at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00615">
        <property type="entry name" value="Orn_deC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000310">
        <property type="entry name" value="Orn/Lys/Arg_deCO2ase_major_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008286">
        <property type="entry name" value="Prn/Lys/Arg_de-COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036633">
        <property type="entry name" value="Prn/Lys/Arg_de-COase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01276">
        <property type="entry name" value="OKR_DC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03711">
        <property type="entry name" value="OKR_DC_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55904">
        <property type="entry name" value="SSF55904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OKR_DC_1" evidence="3">
        <location>
            <begin position="7"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="OKR_DC_1_C" evidence="4">
        <location>
            <begin position="410"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH86212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="494" mass="52393" checksum="7C5E6427FBA13E47" modified="2015-07-22" version="1">MDHSRAPVLEALGHYRRDGLLPFTPPGHKQARGADPEVREVLGDAVFASDVLAISGLDDRRASGGVLRDAELLMADAVRAEHTFFSTCGSSLSVKAAMLAVAGPYEKLLVGRDAHKSVVSGLILSGLRPVWVEPSFDDERHLAHPPSPAAYERAFTEHPDARGALVTSPTPYGSCADLAALAGICHRRGRPLLVDEAWGAHLPFSDRLPTWAMDAGADVCVTSIHKMGSGLEQGSVFHLQGDRIDPAVLRSRADLLGTTSPSVLIYAGLDGWRRQMALHGPRLLDRALDLAAHVRARIEDIPGLHVDGHAEYAGTGLAAALDPLPVVIDLAGLDLSGYAAADWLLRHHRLTTHLADHRRISTQLTHADDESTAGALLEALRDLAAHAAELPRPARVAVPSAAELRLEQTCLPRDAYFGAVADVPIGEAAGRVAAEMLTPYPPGIPVALPGERLNGPVLDYLATGIRAGMYVPDAADPRLRTVRVLAGEGPAPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NHV7</accession>
    <name>A0A0F7NHV7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA polymerase III subunit beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_25980</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DprA/Smf family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_25980"/>
    <dbReference type="EnsemblBacteria" id="AKH87039">
        <property type="protein sequence ID" value="AKH87039"/>
        <property type="gene ID" value="AA958_25980"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_25980"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5470"/>
    <dbReference type="OrthoDB" id="1881437at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009294">
        <property type="term" value="P:DNA-mediated transformation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003488">
        <property type="entry name" value="DprA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43022">
        <property type="entry name" value="PTHR43022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02481">
        <property type="entry name" value="DNA_processg_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00732">
        <property type="entry name" value="dprA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH87039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="415" mass="43747" checksum="A2920AC3E503E5C5" modified="2015-07-22" version="1">MRTPAARPRRGPGSGARPAARSRQGTEPAPEAGLAEAAECDAERLARVALTRLVEPGDEVAGRWLRTHGAVALMRWVTGDAPPPSPEAETRLVRYRRRLGGPAPREDLAAAEAVGARFVCPGDPEWPRQLDDLAAARPLGLWVRGRADLRLWALKSVAVVGARACTEYGAHVAATLAAGLAHAGWTVVSGSAYGIDAAAHRGALAATGATVGVLACGVDRVYPPGHSELLGRVAEQGLIVAELAPGDHPTRSRFLLRNRVMAALTRGTVVVEAERRSGSLVTARWAQRLGRPTMGVPGPVTSGLSSGVHELLRGEAVLVTEAAEVVELVGRIGADLAPVRRGPVVPRDLLPPATARVLEALPGRGTAPLEQIAHEAGTERDEALGRLHELQSLGFVRRDGTGWRLAPRSSEHPKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MY52</accession>
    <name>A0A0F7MY52_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_02165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0047 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014534.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_02165"/>
    <dbReference type="EnsemblBacteria" id="AKH81170">
        <property type="protein sequence ID" value="AKH81170"/>
        <property type="gene ID" value="AA958_02165"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_02165"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.466"/>
    <dbReference type="OrthoDB" id="1691156at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001602">
        <property type="entry name" value="UPF0047"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035917">
        <property type="entry name" value="YjbQ-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30615">
        <property type="entry name" value="PTHR30615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01894">
        <property type="entry name" value="UPF0047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004681">
        <property type="entry name" value="UCP004681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111038">
        <property type="entry name" value="SSF111038"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00149">
        <property type="entry name" value="TIGR00149_YjbQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="140" mass="14979" checksum="33A372CF7F47DE70" modified="2015-07-22" version="1">MTDVFTTHALRITTGSGETVHDLTAECDAFLREAADGRDGLLNVFVPHATAGIALIETGAGSDDDLLAALHDLLPADDRWNHRHGSPGHGRDHVLPALVPPHATLPVIGGRLELGTWQSVVLVDTNRDNPQRSVRLSFLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MYP4</accession>
    <name>A0A0F7MYP4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription antitermination protein NusB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Antitermination factor NusB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">nusB</name>
        <name evidence="9" type="ORF">AA958_03145</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the NusB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014699.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_03145"/>
    <dbReference type="EnsemblBacteria" id="AKH81340">
        <property type="protein sequence ID" value="AKH81340"/>
        <property type="gene ID" value="AA958_03145"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_03145"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.670"/>
    <dbReference type="OrthoDB" id="1574817at2"/>
    <dbReference type="Proteomes" id="UP000034283">
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    </dbReference>
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        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="NusB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011605">
        <property type="entry name" value="NusB_fam"/>
    </dbReference>
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        <property type="entry name" value="NusB_RsmB_TIM44"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0889">Transcription antitermination</keyword>
    <keyword evidence="4 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NusB" evidence="8">
        <location>
            <begin position="6"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="136"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH81340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="226" mass="23805" checksum="D104F31B54F23B93" modified="2015-07-22" version="1">MAARNTARKRAFQIIFESDQRGAPAGQVLEDWIRLGRTDPRQPPVGDFTRRLVEGYAEHAARIDELLSSYSVGWTLDRMPVVDRSILRLGAYELIWEDETPDAVAIDEAVQLTKEFSTDDSPGFVNGLLGRLQELKPRLRRDTDEGPAAAAEAVPEPGADAVGASAPRDAGADPGRDTAADGSRSAARDESGDAAATGDSGGAAAEQVPGAPPAEDVPDGARSDAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MZI1</accession>
    <name>A0A0F7MZI1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase_S9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_05265</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015059.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_05265"/>
    <dbReference type="EnsemblBacteria" id="AKH81705">
        <property type="protein sequence ID" value="AKH81705"/>
        <property type="gene ID" value="AA958_05265"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_05265"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1105"/>
    <dbReference type="OrthoDB" id="721431at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519606" description="Peptidase_S9 domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S9" evidence="2">
        <location>
            <begin position="185"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH81705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="379" mass="38980" checksum="191E7D73F89111EB" modified="2015-07-22" version="1">MRIKPAAAALTSLLAAGVGAGAAAVAAGRYGSRAALRPAPAGPVGFQGPRLRVIAEAGGQVTLGPGSPPALRPETYGLTGRDVHAVVGPLVRAESWPGGRLVRRLERVTYGSLDAGTRVRLTPKVYVGTPRSALGIAYQEVTVAGPLGALPAWYVPGTRGTWVIAAHGLGDTREQALTALPFLHELGLPVLAPAFRGDPGAPPVPGGRGALGRAEWPDLDAALHWAVRHGARRAVLYGWSTGATMALRTAAESAAAYGIAGLVLDSPVLDWRAAVRALSGRSGAPGRLPLPGRLRGLAVLAAGEYPELDTALAVPEAPTLVLQGQADDIAPLAAARAFAARGGDKMLLREVPDGGHATLWNATPAAYEETVRRFLTPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MZR3</accession>
    <name>A0A0F7MZR3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidase_S8 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AA958_02280</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014555.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH81191">
        <property type="protein sequence ID" value="AKH81191"/>
        <property type="gene ID" value="AA958_02280"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_02280"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.489"/>
    <dbReference type="OrthoDB" id="923655at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519084" description="Peptidase_S8 domain-containing protein" evidence="7">
        <location>
            <begin position="29"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S8" evidence="8">
        <location>
            <begin position="226"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="65"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="985"/>
            <end position="1008"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH81191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="1129" mass="117664" checksum="24EB4096FAB5ED49" modified="2015-07-22" version="1">MSSRRLSQHVRAAVTALLLGGLTLPALSATPAAAGPPPLAAPPAGGAAPSASATVTLVTGDEVTLDAPAADGPPAVSVTPRPGSGSRSFTTLRDGDDVYVVPDDAAGLVPEVLDLELFNVTALVEMGYDDASTRALPLIVQGPRPLAAAGEAAREDALPLPALDAVAVELPKKRAGTFAATLARPAGPAAAGVRRVWLDRSLEAAELDGNLSQIGAPEVWDAGLSGAGVDVAVLDSGVDADHPDLRGRVAGAADFTGEGTTEDRNGHGTHVASVVAGSGAASGGARKGVAYGARLLSGRVLDGEGQGRASWVIAGMQWATEQGADVVNLSLGGTAPEYPENDPVARALDTLAADTGTLFVVAAGNSGPYSGTIGSPGVAESALTVGAVDAGGGTPRFTSIGPTTGAYLSKPDLAAPGVAVTGARAGGGTADPYTEMSGTSQATPHVAGAAALLLEKHPDWDWRRLKTTLMTTADGDAAAPRPHAAGAGVLDLPGAANETLRLDRGNVDFGYLRYPEGERPASIEVTLTNNGTEPRAISLTDLATERAGAPLAEDAVSVTPAAVTVAPGATERVTVTLTPEGVAPGVYSGAVVLTESGHDTVTLPLSFYLEPPRHDVDLTVLDRNGRPWAGGSLWLLNMRETYPETGGGFRTVHLDENGRATARMLPGPLSMLAKVETPAADGEAGTVAFAGSPEVMLDGDMAYTIDARKALPLRPATVEGADTRVRHASVHYARHDESGTGGMDEGIYATGEEIEQGRVFLQPTEPVRHGTSAFATRWRLEADGRPQGRQADVYELVLGQGRTIPDPPRYRVTRAEARQLARVEADYRSLHGRADTYTESREARPAGIETALVHEYPLDVPQRRVEMVTARPDVKWRHCVLGPEPALPRLCAPTLPYERGESAAPVWYGAPAPAVIAGLHYGDQLDLPVSLSDGEHQGSIWNIATAGNESLRLFRDGREIPARPGTSYFPVAPEPATYRLEHTSRPDRDALPIGGETRTSWTFPARGPADPLVGQERVRLLGVDYAPRTDRDGTVPAHRPLTVGLRLTSTAGPEDAIRTERGSVRFWASTDGGERWHEALVFPGRDGELTALVPGVWPRPGQEVSVRVRGTAAEGRAIEQTIIDAYRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MZW9</accession>
    <name>A0A0F7MZW9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">zinc_ribbon_15 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_02635</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014614.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_02635"/>
    <dbReference type="EnsemblBacteria" id="AKH81251">
        <property type="protein sequence ID" value="AKH81251"/>
        <property type="gene ID" value="AA958_02635"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_02635"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.563"/>
    <dbReference type="OrthoDB" id="1966455at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031493">
        <property type="entry name" value="Zinc_ribbon_15"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17032">
        <property type="entry name" value="zinc_ribbon_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zinc_ribbon_15" evidence="2">
        <location>
            <begin position="19"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH81251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="116" mass="12624" checksum="2B991E60A393C1B9" modified="2015-07-22" version="1">MIIFGTRTTAAQLAVINLLCGMCGNPAAHSLLKRVTKFTLFFIPLFPVSTKYFTQCTFCGASGQITKEQSEQFQLQVAPQPAPQQGTGNPFAQEPASQQQPQPGGRHPYSRDPHSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0L7</accession>
    <name>A0A0F7N0L7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Carbohydrate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_00470</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FGGY kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH80889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014255.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_00470"/>
    <dbReference type="EnsemblBacteria" id="AKH80889">
        <property type="protein sequence ID" value="AKH80889"/>
        <property type="gene ID" value="AA958_00470"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_00470"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.110"/>
    <dbReference type="OrthoDB" id="233605at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018483">
        <property type="entry name" value="Carb_kinase_FGGY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00933">
        <property type="entry name" value="FGGY_KINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00445">
        <property type="entry name" value="FGGY_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FGGY_N" evidence="2">
        <location>
            <begin position="4"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="FGGY_C" evidence="3">
        <location>
            <begin position="241"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH80889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="475" mass="49843" checksum="17A0CCD85FD7AB1E" modified="2015-07-22" version="1">MSAILAIDQGTSGTKAIVVDAEEGIVSLAEETIRPTYLPGGGVEQDPHELLGSVLGTGSRAVREAGRPIDCVALANQGETILAWDPATGAPLSPALVWQDRRAESVCAELADRAGDIARRTGLVLDPYFSAPKMAWLRRHLTREGVVTTTDTWLVHHLTGEFVTDAATASRSLVLDLTSATWDDELLGLFGLGGERLPRIVASDEIAGTTRAFGPAVPVAGLVVDQQAALVAEGCLEPGSAKCTYGTGAFLLANTGRNPVRSGAGLTTSVAWQRHGHTTYCVDGQVYTVASAVRWLEDLGLVRSATELDSLAATDTERVLCVPAFAGLAAPWWAPDAAASFTGMTLATRREHLVGAVLQGIAAQVAELCTLVAGDIGTPLRRLRADGGLTRSAALMQAQADIAQIPVDVYPHDHATPLGAAALARCALDPALSLAEAVGDWQPTTVYEPRWPRERAEEFRTAWAAAAEAAKGDPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0U4</accession>
    <name>A0A0F7N0U4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LuxR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_01000</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH80979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014345.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_01000"/>
    <dbReference type="EnsemblBacteria" id="AKH80979">
        <property type="protein sequence ID" value="AKH80979"/>
        <property type="gene ID" value="AA958_01000"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_01000"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.221"/>
    <dbReference type="OrthoDB" id="1687028at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="4"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="146"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH80979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="219" mass="23028" checksum="CBF285F426D5AB38" modified="2015-07-22" version="1">MPVSVLLVDDDALVRAGLRAILEAQPDIEVAGEAADGAAVIPLVRRLAPDVIAMDVRMPLMDGIEATRAVLRAFPEPPKILVVTTFEEDRYVYGALRAGADGFLLKRARPAEIVHAVRLVAEGESLLFPAALRSLAAGHGNEEARAALAAARLTEREGEVLRLIARGLTNAEIAAELVLGTETVKSHVSALLAKLGARDRTQAVITAYESGFVAPGAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0W6</accession>
    <name>A0A0F7N0W6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7 9">GTPase Der</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">GTP-binding protein EngA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">der</name>
        <name evidence="12" type="ORF">AA958_04895</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 9">GTPase that plays an essential role in the late steps of ribosome biogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Associates with the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8 9">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014996.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_04895"/>
    <dbReference type="EnsemblBacteria" id="AKH81641">
        <property type="protein sequence ID" value="AKH81641"/>
        <property type="gene ID" value="AA958_04895"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_04895"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1030"/>
    <dbReference type="OrthoDB" id="263682at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00195">
        <property type="entry name" value="GTPase_Der"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031166">
        <property type="entry name" value="G_ENGA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016484">
        <property type="entry name" value="GTP-bd_EngA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032859">
        <property type="entry name" value="KH_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14714">
        <property type="entry name" value="KH_dom-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006485">
        <property type="entry name" value="GTP-binding_EngA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03594">
        <property type="entry name" value="GTPase_EngA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
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        <property type="entry name" value="G_ENGA"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 7 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 7" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="EngA-type G" evidence="11">
        <location>
            <begin position="59"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="EngA-type G" evidence="11">
        <location>
            <begin position="234"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="65"/>
            <end position="72"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="112"/>
            <end position="116"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="174"/>
            <end position="177"/>
        </location>
        <ligand>
            <name>GTP</name>
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        </ligand>
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        <location>
            <begin position="240"/>
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        </location>
        <ligand>
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            <begin position="287"/>
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        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
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        </ligand>
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        <location>
            <begin position="352"/>
            <end position="355"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>2</label>
        </ligand>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00008279"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00020953"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00195"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01049"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AKH81641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="496" mass="53991" checksum="6F5D112C5DB687DD" modified="2015-07-22" version="1">MSETGISPEEGPDGPAHGDEHGELGDAEYAEFMELAAEEGFDLDEVEGDLARAGHGPLPVVAVVGRPNVGKSTLVNRIIGRREAVVEDRPGVTRDRVSYEAEWAGRQFKVVDTGGWEQDVLGIHASVAAQAEYAVETADAVVFVVDTQTGATDTDEAVVKMLRRAGKPVVLCANKVDGQSGESEAAYLWSLGLGEPHPVSALHGRGTGDMLDAVLDVLPDAPAQSFAGGLGGPRRVALIGRPNVGKSSMLNKLAKEDRVVVDDVAGTTRDPVDELIELGGKTWRFVDTAGIRRRVHLQEGADYYASLRTAAALEKAEVAVVLVDAGETLTVQDTRIISMAVEAGRALVIAYNKWDLLDEERRFYLEREIERDLVQVQWAPRVNVSARTGRHMEKLVPGLETALAGWETRVPTGRLNAFLGELVAGQPHPVRGGKQPRILFGTQAGTRPPRFVLFASGFIEANYRRFIERRLREEFGFEGSPIRISVRVREKRGRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0Z0</accession>
    <name>A0A0F7N0Z0_9ACTN</name>
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        <submittedName>
            <fullName evidence="2">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">AA958_01350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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    <dbReference type="PATRIC" id="fig|444103.5.peg.298"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519054" evidence="1">
        <location>
            <begin position="33"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="412" mass="44056" checksum="4A25BD4A35B701F8" modified="2015-07-22" version="1">MARRARIATALAVVSALGLAACGDGGGGEVSADAEQTLTVWAMGEEGTRIQEIAKQFNEDHPNITIKVTPIGWDVAHQKLVSAAAAGKLPDMAQLGSTWVGEFIDLGVLEPVDTGTFSADDFFAAAWEGNERDGEVYGVPWYVDTRVLYYRTDLAAKAGVDEAPETWADQLALAEAYKGLESTKWGFSLPAGGVGAWQNWMPYLFSAGGSLLDDDGNLTLDSPEAVESFTEYRKYFDKGLSKSTPEAPGYDVIKDFGADRVPMFASGPWMVQNITDQAPQLKGKWDVVPLPAGDEPASIIGGASLVTFGDSEHKAAAKEFTSFLTDPKTQADWYEMAKSLPANTAAWDEPALQNADVGAFQEALDTAGTIPPLAKWEEIAHEIDLTLEELGKGGDPAELAKQLQEKTEGLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N1C4</accession>
    <name>A0A0F7N1C4_9ACTN</name>
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        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
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        <name evidence="3" type="ORF">AA958_02270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
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    <dbReference type="EnsemblBacteria" id="AKH81189">
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        <property type="gene ID" value="AA958_02270"/>
    </dbReference>
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    <dbReference type="PATRIC" id="fig|444103.5.peg.487"/>
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    <dbReference type="Proteomes" id="UP000034283">
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
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        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HTH_TETR_2"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="14"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH81189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="216" mass="22903" checksum="B7F91DE98A82E0D3" modified="2015-07-22" version="1">MAGTRVDGRVERGNHTRRLVLRRTMDIASVEGLEGLSLGRIANELGLSKSGVFALFGSKEELQLATVRAAGAVFAKTVVGPVQDQPPGVGRLLSLCSHWLRYSRERVFPGGCFFYGAAAEFASRSGAVHDAVAAAHRDWAAYVERTVEEARAAGELRPDTGAGRLAFELIALLEHANLLSLLHGAQDAYDLAASAVVARLRAAAAEPDSVPDALPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N1F8</accession>
    <name>A0A0F7N1F8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_09255</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_09255"/>
    <dbReference type="EnsemblBacteria" id="AKH82385">
        <property type="protein sequence ID" value="AKH82385"/>
        <property type="gene ID" value="AA958_09255"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_09255"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1953"/>
    <dbReference type="OrthoDB" id="1341696at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029024">
        <property type="entry name" value="TerB-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158682">
        <property type="entry name" value="SSF158682"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH82385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="231" mass="24601" checksum="6147543F9D793A3C" modified="2015-07-22" version="1">MEVDVTHILRRFAGVRTSWHTESDGEFFCPGCGGDRNYRRRSGRRRFTVLGVPVLPRGAAGPVVECADCGGHFGLTSLAEPTSTRFALLLRDATHAVALAVLHAGGTSSSAVRCAAVTAVRTAGYDDCTEEQLLTLLAAIEADSGRMPELCADLPPEQRNFEAELRETLAPLAPHLVPVGRESILLSGARIALADGAYTPPEWETLVVVGDALLLPASDVERLLTSARTPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N1X6</accession>
    <name>A0A0F7N1X6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cysteine desulfurase</fullName>
            <ecNumber evidence="5">2.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AA958_06865</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[sulfur carrier]-H + L-cysteine = [sulfur carrier]-SH + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:43892"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="EC" id="2.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the sulfur carrier protein TusA family.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.7" evidence="5"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015333.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_06865"/>
    <dbReference type="EnsemblBacteria" id="AKH81981">
        <property type="protein sequence ID" value="AKH81981"/>
        <property type="gene ID" value="AA958_06865"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_06865"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1435"/>
    <dbReference type="OrthoDB" id="839689at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044571">
        <property type="term" value="P:[2Fe-2S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010240">
        <property type="entry name" value="Cys_deSase_IscS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001455">
        <property type="entry name" value="TusA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036868">
        <property type="entry name" value="TusA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11601:SF34">
        <property type="entry name" value="PTHR11601:SF34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01206">
        <property type="entry name" value="TusA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64307">
        <property type="entry name" value="SSF64307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01148">
        <property type="entry name" value="UPF0033"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UPF0033" evidence="9">
        <location>
            <begin position="391"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS01148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AKH81981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="461" mass="48084" checksum="3620E3C66CFBFBF4" modified="2015-07-22" version="1">MPYFDAASSAPLHPIARQALLAALDEGWADPARLYREGRRARRLLDAARETTADLVGCRPDELVFTSSGTRAVHDGIAGALAGRRRAGRHLVVSPVEHSAVLHAAERHEAAGGEVTYVPVDRGGRVAPGAYAEVLRPDTALACLQSANHEVGTEQPVAEAAEECRAAGVPLLVDAAQSLGWGRTEGPWSLLAASAHKWGGPPGVGLLAVRKGTRFAPAGPADERESGRAPGFENIPAIVATAASLRAVRGEAEAEDARLRALVDRIRARVPETVADVEVMGDPERRLPHLVTFSCLYVDGEALLHALDRAGFSVSSGSSCTSSTLTPSHVLKAMGVLSEGNVRVSLPQGTSVEDVEGFLGALQGAVAGVRAELGAPVSGAAGETPGGELVVDARGRRCPVPVIELAKVFDRVPVGGTALVLSDDEAARLDIPAWCEMRGQEYVGEEPAAGGGTGYRVRRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2F7</accession>
    <name>A0A0F7N2F7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription-repair-coupling factor</fullName>
            <shortName evidence="8">TRCF</shortName>
            <ecNumber evidence="8">3.6.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">mfd</name>
        <name evidence="11" type="ORF">AA958_11880</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">In the C-terminal section; belongs to the helicase family. RecG subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">In the N-terminal section; belongs to the UvrB family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="8"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016151.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_11880"/>
    <dbReference type="EnsemblBacteria" id="AKH82815">
        <property type="protein sequence ID" value="AKH82815"/>
        <property type="gene ID" value="AA958_11880"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_11880"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2497"/>
    <dbReference type="OrthoDB" id="234717at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000716">
        <property type="term" value="P:transcription-coupled nucleotide-excision repair, DNA damage recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00969">
        <property type="entry name" value="TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036101">
        <property type="entry name" value="CarD-like/TRCF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003711">
        <property type="entry name" value="CarD-like/TRCF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004576">
        <property type="entry name" value="Mfd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037235">
        <property type="entry name" value="TRCF-like_C_D7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005118">
        <property type="entry name" value="TRCF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041471">
        <property type="entry name" value="UvrB_inter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02559">
        <property type="entry name" value="CarD_CdnL_TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03461">
        <property type="entry name" value="TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17757">
        <property type="entry name" value="UvrB_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01058">
        <property type="entry name" value="CarD_TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00982">
        <property type="entry name" value="TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141259">
        <property type="entry name" value="SSF141259"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143517">
        <property type="entry name" value="SSF143517"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00580">
        <property type="entry name" value="mfd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="649"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="835"/>
            <end position="985"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AKH82815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="1184" mass="129195" checksum="47B5502D00AEB355" modified="2015-07-22" version="1">MSLYGLLDAVVRDPALAEAVTAAEGGVRPQVDLVGPPAARPFALAALAARTRRPVLAVTATGREAEDLAAALRSLMPPGREDAVVEYPAWETLPHERLSPRSDTVGRRLAVLRRLAHPDPDDAAAGPVSVVVAPVRSVLQPQVKGLGDLKPVALRSGRSADLEETVQALGAAAYSRVELVEKRGEFAVRGGILDVFPPTEEHPLRVEFWGDDIEEIRYFKVADQRSLEVAEHGLWAPPCRELLLTGSVRARAADLAVRHPQLGEMLGKIAEGIAVEGMESLAPVLVDDMELLLDVLPAGSMAVSCDPERVRTRAADLVATSQEFLQASWAASAGGGEAPIDLELLGRASLWGIADVREHARELGMMWWSVSPFSADAELEDDTLELGLHAPEVYRGDTARALADTKGWLADGWRVVYLTEGHGPAQRTTEVLGGEGIAARLDADLAPDALAPSVVHVSCGELDHGFVAPGLRLAVLTETDLSGQKAAGREGARMPARRRKQIDPLTLQAGDYIVHEQHGVGRYLEMVQRTVQGATREYLLVEYAPAKRGQPGDRLYIPTDQLDQVTKYVGGEAPTLHRLGGSDWAKTKSRAKKAVKEIAADLIKLYSARMAAPGHAFAGDTPWQRELEDAFPYVETPDQLSTITEVKEDMEKPIPMDRLVCGDVGYGKTEIAVRAAFKAVQDGKQVAVLVPTTLLVQQHMGTFSERYAQFPVVVRALSRFQTDTEARAVLDGLREGSVDIVIGTHRLFSSDTRFKDLGLVIVDEEQRFGVEHKEQLKKLRANVDVLTMSATPIPRTLEMAVTGIREMSTITTPPEERHPVLTFVGPYEEKQIGAAIRRELLREGQVFYIHNRVESIDRAAARLRQAVPEARVATAHGQMSESALEQVVVDFWEKKFDVLVSTTIVENGIDISNANTLIVERGDTFGLSQLHQLRGRVGRGRERGYAYFLYPPEKPLTETAHERLATIAQHTEMGAGMYVAMKDLEIRGAGNLLGGEQSGHIAGVGFDLYVRMVGEAVADYRATLEGGTEEAPPPEVKIELPVDAHVPHDYAPGERLRLAAYRAIASVTSEDDIRAVREELTDRYGPLPEPVENLLLVAGLRMLARSCGVADITLQGTRIRFSPVSLRESQELRLKRLYPGAVVKPALNQILVDRPKPKQMGAQPLKGRELLAWVGELLTTILDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2I3</accession>
    <name>A0A0F7N2I3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ACP S-malonyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_08175</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015561.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_08175"/>
    <dbReference type="EnsemblBacteria" id="AKH82211">
        <property type="protein sequence ID" value="AKH82211"/>
        <property type="gene ID" value="AA958_08175"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_08175"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1725"/>
    <dbReference type="OrthoDB" id="1123553at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_AT" evidence="2">
        <location>
            <begin position="5"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH82211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="316" mass="31822" checksum="8566DACAF74BED01" modified="2015-07-22" version="1">MLVLVAPGQGAQTPGFLTPWLDLPGVAERLSAWSDVAGLDLVRAGTEADEDEIRDTAVAQPLLVAAALVSAYALFEGPGPLHRQVGMVAGHSVGELTAAALAGVITDEEAIALVRARGLAMAEAAAVTETGMSAVLGGEQDTVLAHLDRLGLTPANVNGAGQIVAAGTAAQLAELAEEKPEGARRVVPLKVAGAFHTEHMKSAVAALAAKTGQLTPADPRIPYVSNGDGRVVASGAEVVERLVAQVASPVRWDACMETFAAHGATALVEAAPGGTLTGLAKRALKGVAAVPLKTPEDIEKARAAVAGTAAAAEEST</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2N8</accession>
    <name>A0A0F7N2N8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Dihydrofolate reductase</fullName>
            <ecNumber evidence="3 6">1.5.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AA958_08560</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(6S)-5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:15009"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57451"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 5,6,7,8-tetrahydrofolate from 7,8-dihydrofolate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6 7">Belongs to the dihydrofolate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.3" evidence="3 6"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015624.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_08560"/>
    <dbReference type="EnsemblBacteria" id="AKH82276">
        <property type="protein sequence ID" value="AKH82276"/>
        <property type="gene ID" value="AA958_08560"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_08560"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1806"/>
    <dbReference type="OrthoDB" id="1920912at2"/>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00158"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004146">
        <property type="term" value="F:dihydrofolate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006545">
        <property type="term" value="P:glycine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00209">
        <property type="entry name" value="DHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012259">
        <property type="entry name" value="DHFR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017925">
        <property type="entry name" value="DHFR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001796">
        <property type="entry name" value="DHFR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48069">
        <property type="entry name" value="PTHR48069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00186">
        <property type="entry name" value="DHFR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000194">
        <property type="entry name" value="DHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00075">
        <property type="entry name" value="DHFR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51330">
        <property type="entry name" value="DHFR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="5 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHFR" evidence="8">
        <location>
            <begin position="2"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH82276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="165" mass="17675" checksum="D08ADC281C381680" modified="2015-07-22" version="1">MNVGLIWAQARDGVIGAHNGIPWRLPEDMAHFKATTLGHPVVMGRRTWDSLPPRFRPLPGRRNVVVTRDPRWAAEGAVGAGSVDGALELAAGSPAATTVWVIGGGEVYRAALGHATTLSVTEVDTEVAGGDTYAPVPGTEWRVAEDGGWQLSRSGLRYRIRTLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2Q2</accession>
    <name>A0A0F7N2Q2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_05150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_05150"/>
    <dbReference type="EnsemblBacteria" id="AKH81684">
        <property type="protein sequence ID" value="AKH81684"/>
        <property type="gene ID" value="AA958_05150"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_05150"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1082"/>
    <dbReference type="OrthoDB" id="1978329at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021449">
        <property type="entry name" value="DUF3099"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11298">
        <property type="entry name" value="DUF3099"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH81684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="131" mass="14323" checksum="6C09C37A7D3F3447" modified="2015-07-22" version="1">MKRKRRGDADVFRITGARQSLDDDVRGRQRRYVISMTIRAVSVVAAALLWNVQRHTAVVALILGMFIPYFAVIIANAGRESIRSLPSTFVVAPERRVIAPPRRTARESGAPGERAPAGDESTTSESAPPPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2V9</accession>
    <name>A0A0F7N2V9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Rrf2 family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_12755</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_12755"/>
    <dbReference type="EnsemblBacteria" id="AKH82950">
        <property type="protein sequence ID" value="AKH82950"/>
        <property type="gene ID" value="AA958_12755"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_12755"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2680"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030489">
        <property type="entry name" value="TR_Rrf2-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000944">
        <property type="entry name" value="Tscrpt_reg_Rrf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33221">
        <property type="entry name" value="PTHR33221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02082">
        <property type="entry name" value="Rrf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00738">
        <property type="entry name" value="rrf2_super"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01332">
        <property type="entry name" value="HTH_RRF2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51197">
        <property type="entry name" value="HTH_RRF2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH82950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="159" mass="17232" checksum="F2A43A355E631CE1" modified="2015-07-22" version="1">MRMSEGVEWALHSCLNLAWAGPDRPVTAARLAAYHELPAPYLNKQLQALVRAGIVVSASGPRGGFRLARPLARITLMDVVAAVEGPDEVFRCTEIRQQGPGGGAPASYRPPCAFAHAMARAELAWRRELAGQTLDDVREQAEAQAPAAPERLRRWLANG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2Z7</accession>
    <name>A0A0F7N2Z7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_13125</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016347.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_13125"/>
    <dbReference type="EnsemblBacteria" id="AKH83015">
        <property type="protein sequence ID" value="AKH83015"/>
        <property type="gene ID" value="AA958_13125"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_13125"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2762"/>
    <dbReference type="OrthoDB" id="1745184at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="22"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH83015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="261" mass="26885" checksum="B72B8A8A1E042C56" modified="2015-07-22" version="1">MVPLTDAPRQPRGRGPQQDRSRATRQRLLEAAVACLAELGWGGSTVSVVAERAGVSRGAAQHHFPTREDLFTAAVEHVAAERSAALRGLLPAAGAADSRRAEGADAIRAAPTGAVGAAAEKAVGGKAPAGTEATAGGAAAATPLADAATAAVVRGVVDLYTGPLFRAALQLWVAAANEEQLRPRVAALEARVGREAHRMTVALLGADESVPGVRETVQGFLDMARGLGLATLLTDDSARRDRVVTQWSHLLTTALSNAHPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N306</accession>
    <name>A0A0F7N306_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_05505</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015097.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_05505"/>
    <dbReference type="EnsemblBacteria" id="AKH81743">
        <property type="protein sequence ID" value="AKH81743"/>
        <property type="gene ID" value="AA958_05505"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_05505"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1154"/>
    <dbReference type="OrthoDB" id="1425840at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="242"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="265"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="3">
        <location>
            <begin position="10"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="3">
        <location>
            <begin position="165"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH81743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="318" mass="31748" checksum="C7C63096BCB5B0B5" modified="2015-07-22" version="1">MGVTAVSAGLVAFWSSGFIGAELGTREAAADTLLMWRFLAAAVLFAGGWLLLRRRRLPRRALGEQAVIGALSQGGYLGAIVWAVGLGVPAGSAALIAALQPLAAGALAGPLLGERVSRRQWAGLAVGLAGVALVVRDDLGGAGAAPPWAYALPFAGMAALLGASFLERRARSPLPPADAVPVHVLVSAALFSAVALAGGRGAPPASGGFWLAVAWVVVLSTAGGYGFYWLSLRRSGVTVTSALMYLTPPVTALWAYAMFGEAPGPVAVAGMGVAAAGVAAATLGTGAAPSPAGDRGRNGSAGVPVRPTRAEPRTGAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N332</accession>
    <name>A0A0F7N332_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">6-phosphogluconolactonase</fullName>
            <shortName evidence="7">6PGL</shortName>
            <ecNumber evidence="5 7">3.1.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">pgl</name>
        <name evidence="9" type="ORF">AA958_05645</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 7">Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12556"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57955"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="EC" id="3.1.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 7">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 7">Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.31" evidence="5 7"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015122.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_05645"/>
    <dbReference type="EnsemblBacteria" id="AKH81768">
        <property type="protein sequence ID" value="AKH81768"/>
        <property type="gene ID" value="AA958_05645"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_05645"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1182"/>
    <dbReference type="OrthoDB" id="1828393at2"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00409"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017057">
        <property type="term" value="F:6-phosphogluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01400">
        <property type="entry name" value="6PGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005900">
        <property type="entry name" value="6-phosphogluconolactonase_DevB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006148">
        <property type="entry name" value="Glc/Gal-6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039104">
        <property type="entry name" value="PGLS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11054">
        <property type="entry name" value="PTHR11054"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01182">
        <property type="entry name" value="Glucosamine_iso"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01198">
        <property type="entry name" value="pgl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucosamine_iso" evidence="8">
        <location>
            <begin position="11"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH81768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="260" mass="26913" checksum="0C71898E1BEB5F58" modified="2015-07-22" version="1">MSTPQIVVHRDKELMAEAAAARLITKVVDAQSARGAASVVLTGGRNGNGLLTALAAAPARDAVDWSRLDLWWGDERFLPAGHPDRNATQAGEALLDAVPLDPARVHEMPAAQAAFGADADAAAAAYARELAAAARPEDHGPVPAFDVLLLGVGPDTHVASLFPELPGVRETERTVVGVHGAPKPPPTRISLTLPAIRAAREVWLLAAGEDKARAAAMALSGAGEIQTPAAGARGRTRTLWLLDRPAAALLPPALYPPASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N339</accession>
    <name>A0A0F7N339_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uridine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_05855</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015157.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_05855"/>
    <dbReference type="EnsemblBacteria" id="AKH81804">
        <property type="protein sequence ID" value="AKH81804"/>
        <property type="gene ID" value="AA958_05855"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_05855"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1225"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH81804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="213" mass="23593" checksum="8B3A9C55524254A2" modified="2015-07-22" version="1">MQLEPISWERLTEALAERIAETKAADGGLRLRVAVDGPPAAGPGALAARVGDALRVRGREALVLDTGGFLRAASLRYEFGREDPDAYYDIWLDTGALWREVFGPLEPGGDGRVLPDLWDPATDRATRSPYVRLPPGGVVLLHGPLLLGRWFPFDFVVHLRLSAAALARRTPEQERWTLPAFARYEEEADPAASADVLVRLDDPRRPAWRPERP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N372</accession>
    <name>A0A0F7N372_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dephospho-CoA kinase</fullName>
            <ecNumber evidence="1">2.7.1.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Dephosphocoenzyme A kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">coaE</name>
        <name evidence="2" type="ORF">AA958_05880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3'-dephospho-CoA + ATP = ADP + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18245"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57328"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.24"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 5/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CoaE family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.24" evidence="1"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015161.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_05880"/>
    <dbReference type="EnsemblBacteria" id="AKH81808">
        <property type="protein sequence ID" value="AKH81808"/>
        <property type="gene ID" value="AA958_05880"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_05880"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1230"/>
    <dbReference type="OrthoDB" id="1515383at2"/>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00356"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004140">
        <property type="term" value="F:dephospho-CoA kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00376">
        <property type="entry name" value="Dephospho_CoA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001977">
        <property type="entry name" value="Depp_CoAkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01121">
        <property type="entry name" value="CoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00152">
        <property type="entry name" value="TIGR00152"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51219">
        <property type="entry name" value="DPCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="11"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="206" mass="21565" checksum="8E57762834B90024" modified="2015-07-22" version="1">MLTVGLTGGIGAGKSAVSRLLVSYGAVLVDSDKIAREVVEPGTPGLAAVVAEFGDGVVAADGSLDRAKLGSIVFADADRRRALNAIVHPLVRERSAALQEAAGPDAIVVNDVPLLAENDLAGLYDVVVVVDASPATQLDRLVRLRGMAPDEARARMAAQATREERLAIADIVVENDGTPEELAERVRKVWEELVARKGVRGRNSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3B6</accession>
    <name>A0A0F7N3B6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Tryptophan synthase beta chain</fullName>
            <ecNumber evidence="11">4.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">trpB</name>
        <name evidence="13" type="ORF">AA958_06155</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D-glyceraldehyde 3-phosphate + H2O + L-tryptophan</text>
            <dbReference type="Rhea" id="RHEA:10532"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.2.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 11">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 11">Tetramer of two alpha and two beta chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the TrpB family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.20" evidence="11"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015212.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_06155"/>
    <dbReference type="EnsemblBacteria" id="AKH81859">
        <property type="protein sequence ID" value="AKH81859"/>
        <property type="gene ID" value="AA958_06155"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_06155"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1286"/>
    <dbReference type="OrthoDB" id="912282at2"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00044"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004834">
        <property type="term" value="F:tryptophan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06446">
        <property type="entry name" value="Trp-synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00133">
        <property type="entry name" value="Trp_synth_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006653">
        <property type="entry name" value="Trp_synth_b_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006654">
        <property type="entry name" value="Trp_synth_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023026">
        <property type="entry name" value="Trp_synth_beta/beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001413">
        <property type="entry name" value="Trp_syn_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00263">
        <property type="entry name" value="trpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00168">
        <property type="entry name" value="TRP_SYNTHASE_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="10 11 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 11" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="PALP" evidence="12">
        <location>
            <begin position="65"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="11">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AKH81859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="413" mass="44213" checksum="D29EAF19161BE26D" modified="2015-07-22" version="1">MPAEFFIPDPERQVPTAEGYFGAYGGKFIPEALRAAVDEVAVAYEKAKDDESFVAELNDLLVHYTGRPSPLTEVPRFAAEAGGARVFLKREDLNHTGSHKINNVLGQALLTRRMGKTRVIAETGAGQHGVATATACALLGLECTVYMGEIDTERQALNVARMRILGAEVVPVKSGSRTLKDAINEAFRDWVANVEHTHYLFGTVAGPHPFPALVRDFHRVIGIEARQQLLDRTGRMPDAAVACVGGGSNAIGLFHAFLPHPAVRLVGCEPAGHGLTSGEHAATLSLGDPGILHGSRSYVLQDEDGQITEPYSISAGLDYPGVGPEHAYLKDAGRAEYRAVTDDEAMQALRLLSRSEGIIPAIESAHALAGALEVGRELGPDGLIVVNLSGRGDKDMDTAARYFGLYDAEEADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3N1</accession>
    <name>A0A0F7N3N1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cholesterol oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_03655</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014790.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_03655"/>
    <dbReference type="EnsemblBacteria" id="AKH81432">
        <property type="protein sequence ID" value="AKH81432"/>
        <property type="gene ID" value="AA958_03655"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_03655"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.769"/>
    <dbReference type="OrthoDB" id="365211at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="6"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="538"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH81432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="585" mass="62890" checksum="6A0EBE36BA51BB70" modified="2015-07-22" version="1">MSSYDVIVIGSGFGGSVAALRLTEKGYKVGVLEAGRRFAREQLPKNSWRLRDYLWAPALGLYGIQRIHLLSNVMVLAGAGVGGGSLNYANTLYVPPPAFFRDRQWGHITDWQEELAPYYDQAQRMLGVRENPTTTEADTYLKTTAERMGAGDSYRLTPVGVFYGDGRDARGETTAAPGETVPDPYFGGAGPERAACLQCGSCMTGCRYGAKNTLTENYLYLAERHGAVIHPLTTVVDVHEAAGGGYEVTTVATNKRRRGKREVLRCDHVVVAAGTYGTQTLLHRMKAGGRLPGLSPRLGELTRTNSEALVGAVTFPRTYRKKRGAGELDFTKGVAITSSIHPNDTTHIENVRYGKGSNAMALLCVPQFKPTGKLPKALRVLGAYLRHPVLVARTATTYRWSERTIIGLVMQTHDNSLTTYLKDKGLGKGLLTARQGHGAPNPVHLPEGAEAARLLAEQIGGQPGTNLGELMGKPLTAHFLGGCPIGEDAEHGVIDPYHRLYGHPGISVVDGSAVSANLGVNPSLTITAQAERAMALWPNKGEKDPRPAQNDPYARVRPVPPRQPAVPAGAFGALLLPIPEVPPKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3Y3</accession>
    <name>A0A0F7N3Y3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GDP-L-fucose synthase</fullName>
            <ecNumber evidence="2">1.1.1.271</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">GDP-4-keto-6-deoxy-D-mannose-3,5-epimerase-4-reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">fcl</name>
        <name evidence="4" type="ORF">AA958_07320</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>GDP-beta-L-fucose + NADP(+) = GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:18885"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57273"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57964"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.271"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nucleotide-sugar biosynthesis; GDP-L-fucose biosynthesis via de novo pathway; GDP-L-fucose from GDP-alpha-D-mannose: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Fucose synthase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.271" evidence="2"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015418.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_07320"/>
    <dbReference type="EnsemblBacteria" id="AKH82068">
        <property type="protein sequence ID" value="AKH82068"/>
        <property type="gene ID" value="AA958_07320"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_07320"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1533"/>
    <dbReference type="OrthoDB" id="1558163at2"/>
    <dbReference type="UniPathway" id="UPA00128">
        <property type="reaction ID" value="UER00191"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050577">
        <property type="term" value="F:GDP-L-fucose synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070401">
        <property type="term" value="F:NADP+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042351">
        <property type="term" value="P:'de novo' GDP-L-fucose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05239">
        <property type="entry name" value="GDP_FS_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00956">
        <property type="entry name" value="GDP_fucose_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028614">
        <property type="entry name" value="GDP_fucose/colitose_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="3">
        <location>
            <begin position="30"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="2">
        <location>
            <position position="159"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="34"/>
            <end position="40"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="128"/>
            <end position="131"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="186"/>
            <end position="189"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="2">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="2">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH82068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="329" mass="35680" checksum="2E10B9A1CBD08D28" modified="2015-07-22" version="1">MTPSNELSSPAGADGLPPAARSFLPPGARVFVAGHRGLVGSAVARRLTADGYDVVTRTRAELDLRDAERTAAWLAAVRPDAVVLAAAKVGGIMANSRFPVQFLEDNLRIQLSVIAGSHAASVRRLLFLGSSCIYPKLAGQPIREDSLLTGPLEPTNQPYALAKIAGIEQVQAYRRQYGAAYISAMPTNLYGPGDNFDLETSHVLPALIRRFHEARETGAEEVVLWGTGTPRREFLHVDDLAAACLTLLRGYDADAPVNVGCGEDLTIRELAETVRDVVGYRGRIAFDTSRPDGTPRKLLDVSRITELGWRPEIGLREGIAAVYEDWRKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3Y8</accession>
    <name>A0A0F7N3Y8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytidyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_07400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015433.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_07400"/>
    <dbReference type="EnsemblBacteria" id="AKH82083">
        <property type="protein sequence ID" value="AKH82083"/>
        <property type="gene ID" value="AA958_07400"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_07400"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1551"/>
    <dbReference type="OrthoDB" id="1465613at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CTP_transf_like" evidence="2">
        <location>
            <begin position="7"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH82083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="161" mass="17909" checksum="3D31CDB7C575F029" modified="2015-07-22" version="1">MAHTVGYAPGVYDLFHVGHLNILRHARSRCDYLVAGVVSDEMAQLAKGRAPVVPLVERLEIVRSIRHVDAAFVETVPDKLETWQQVRFDVIFKGDDWRGTPKGEKLEADFRTVGVEVVYFPYTVHTSSTQLRRALDALADRRPRGEAPVSSSQTAPGTISP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3Z1</accession>
    <name>A0A0F7N3Z1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_15275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016663.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_15275"/>
    <dbReference type="EnsemblBacteria" id="AKH83350">
        <property type="protein sequence ID" value="AKH83350"/>
        <property type="gene ID" value="AA958_15275"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_15275"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3217"/>
    <dbReference type="OrthoDB" id="1728209at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023869">
        <property type="entry name" value="tRNA_Adeno_NH3ase_assoc_put"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03941">
        <property type="entry name" value="tRNA_deam_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="185" mass="19273" checksum="96CA6C69334E9618" modified="2015-07-22" version="1">MYFAALLARTEDGWEASDTELDDVETLDDLADLADLAREATADDDETVLVLLEQEGIWYGVIRIDGEDDPRVFVSNAAGAARSAYGEILLTPELLGQEPEDDSALDSLTDLDGTEDGEPDPAGGSGADAGADPDAPPGTPAGPVGDTELLEDLGVSEKQLLALQSDAVNEIADMLGAADVLEAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4J3</accession>
    <name>A0A0F7N4J3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AA958_16680</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016880.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_16680"/>
    <dbReference type="EnsemblBacteria" id="AKH83575">
        <property type="protein sequence ID" value="AKH83575"/>
        <property type="gene ID" value="AA958_16680"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_16680"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3510"/>
    <dbReference type="OrthoDB" id="1891092at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="90"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="135"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="261"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="9">
        <location>
            <begin position="46"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AKH83575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="286" mass="31476" checksum="FD83C1F699F3D831" modified="2015-07-22" version="1">MSTATETRTQGRTEDLAPVTTESLAELLVSKERPPQPSAWSASVTFGWRAVLKIKHVPEQLFDVTAFPIMMVLMYTYLFGGALAGSTSDYLQYLLPGILVMSIVMITMYTGVSVNTDIEKGVFDRFRSLPIWRPAVMVGYLLGDMLRYLIASVVMVGVGLIMGFRPDGGVVGVLAGVALLIVFSFAFSWIWTMFGLLLRTEKSVMGVSMMVLFPTTFLSDIFVEPETMPGWLQAFVNNNPVTHLAAAVRDLMHGDWPGADIAWTLGWAGAIVAIFGPITMRLYARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4P1</accession>
    <name>A0A0F7N4P1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_09095</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015705.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH82358">
        <property type="protein sequence ID" value="AKH82358"/>
        <property type="gene ID" value="AA958_09095"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_09095"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1916"/>
    <dbReference type="OrthoDB" id="1382282at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="235"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH82358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="453" mass="47946" checksum="F51D5F567C1367E7" modified="2015-07-22" version="1">MTVMARPTDWQPLADSDPVPGNVEDIRDEAARLKKIGETIESQVGKLRDIGKDGALKGKYADKLRSAATDLAGKMEKTSGRYKEVAGHLSTWAGDLDEAQKAAERALTKAQSAAGTMAQNKPPDQASSPDAPEPTDDEKEAEKRREKAYGAAEGELEEARRMLGRATSARDRDADTAAGRIKKSIDDDVKDSWWDNVKDFVDKYADIIKIVIDVISWIATAVAIISLFIPGLNVVAFLLIAGLLVVGGRALLAATGNASWMEVLVDAVGLLTMGLGRAGMAALKGTNALTKTAATGARSQQVAQNLARSSAQRQALGRVLSSRTASPAAKRSARAQIDALKAQARRQATSVPQNLPSVGRLGKILNMGDTEGLSLIRNIGRISDRFPGLVSGGTAAKAGAAYSASLGAAWGGTIVDLGDKAFGSSDMLPFKPFNDSYNDWKGDTWKAPIGSTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N513</accession>
    <name>A0A0F7N513_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_09765</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asp23 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015812.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_09765"/>
    <dbReference type="EnsemblBacteria" id="AKH82469">
        <property type="protein sequence ID" value="AKH82469"/>
        <property type="gene ID" value="AA958_09765"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_09765"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2058"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005531">
        <property type="entry name" value="Asp23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03780">
        <property type="entry name" value="Asp23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="36"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH82469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="126" mass="13530" checksum="4AF0E2590B8D56CF" modified="2015-07-22" version="1">MTTPEASRVEAAARGATHVADRVVAKIAMQAAREALRASSPADGPMRANARAKASVHRQGGNGLGQAHVQVDVDLDYPTRIGSQCAEVRRHVRERVEHLAGMSVRQVAVSVEHLHGPQSSDVERVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N526</accession>
    <name>A0A0F7N526_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_10005</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH82508">
        <property type="protein sequence ID" value="AKH82508"/>
        <property type="gene ID" value="AA958_10005"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_10005"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2105"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH82508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="134" mass="15074" checksum="EC9A332527153D21" modified="2015-07-22" version="1">MIMVSVRLEQAETGLLRVAVPRVSPGIRSSALPTAATEQTIKRPEALTGPRTVSCSRRQIPEPFDPFQVVVRTGRRGGVHPIRDRAVRLRVVDRRDRLQDEAVLDEEVFPQRASRAPVSSVGLMDCWTEPRPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N543</accession>
    <name>A0A0F7N543_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Polyphosphate glucokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_10125</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015865.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_10125"/>
    <dbReference type="EnsemblBacteria" id="AKH82523">
        <property type="protein sequence ID" value="AKH82523"/>
        <property type="gene ID" value="AA958_10125"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_10125"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2132"/>
    <dbReference type="OrthoDB" id="1130699at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH82523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="247" mass="25676" checksum="7DB3B1C1D4E21761" modified="2015-07-22" version="1">MNIMGVDIGGSGIKGAPADLDTGALAEERHKVLTPHPSGPDAVADGVAAVVEHFAGHEGPVGVTFPGVITDGVVRTAANVDKSWVDVDAAALLGDRLGRPVHIVNDADAAGIAELTFGAARGRTGTVIVLTFGTGIGSAVFTGGRLVPNTELGHLELHGHEAEKRASAKEREDKDLSWRHWAHRVQRYLAHLEMLFTPELFVIGGGVSRKADKFLDDITGIRADVVPAELQNNAGIVGAAMAAAAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5Q7</accession>
    <name>A0A0F7N5Q7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acyl-CoA hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_11415</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acyl coenzyme A hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016074.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_11415"/>
    <dbReference type="EnsemblBacteria" id="AKH82738">
        <property type="protein sequence ID" value="AKH82738"/>
        <property type="gene ID" value="AA958_11415"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_11415"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2402"/>
    <dbReference type="OrthoDB" id="1712258at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016790">
        <property type="term" value="F:thiolester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040170">
        <property type="entry name" value="Cytosol_ACT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033120">
        <property type="entry name" value="HOTDOG_ACOT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11049">
        <property type="entry name" value="PTHR11049"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51770">
        <property type="entry name" value="HOTDOG_ACOT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HotDog ACOT-type" evidence="5">
        <location>
            <begin position="16"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH82738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="176" mass="19032" checksum="D941F79430C7A51A" modified="2015-07-22" version="1">MNDQARPAAGEAKPTSASRTTLSSIMTANDANLLGTVHGGVIMKLVDDVAGAVAGRHSGGPAVTASMDEMVFLEPVRIGDLVHVLAQVNWTGRTSMEVGVRVMAERWNESTPAKQVASAYLVFAAVDDQGRPRPVPAVAPETERDERRCQEAQIRRTHRLARRRAIKNLRARSEPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-08-12" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5U5</accession>
    <name>A0A0F7N5U5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_15560</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016703.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH83391">
        <property type="protein sequence ID" value="AKH83391"/>
        <property type="gene ID" value="AA958_15560"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_15560"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3275"/>
    <dbReference type="OrthoDB" id="1785082at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032783">
        <property type="entry name" value="AraC_lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12852">
        <property type="entry name" value="Cupin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="4">
        <location>
            <begin position="211"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH83391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="313" mass="33826" checksum="FAD63ED72D15263C" modified="2015-07-22" version="1">MDSFAGLLDSPHARGAFMMRAILEPPWAVRIMDRAPLSLVAQARGTAWVTYDDAEPVRVGEGEIAIMRGPDPYVFSDDPATEPQALIHPGGRCETPDGRSLAGEMDLGVRTWGHSGDGSAMMLIGSYENTGEISARLLDALPRLVVLRRDAWDCPLLPLLGEEIARDDPGQEVVLDRLLDLLVVAALRAWFARPEARAPGWYRAQGDPVVGRALKLLHNDPAHPWTVAELAVRAGVSRAALARRFAELVGEPPMTYLTGWRLALAADLLREPDATVGAVARRVGYGSPFALSTAFKRVHGVSPQEHRLAAAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N619</accession>
    <name>A0A0F7N619_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidoglycan bridge formation protein FemAB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_16090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FemABX family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016785.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_16090"/>
    <dbReference type="EnsemblBacteria" id="AKH83476">
        <property type="protein sequence ID" value="AKH83476"/>
        <property type="gene ID" value="AA958_16090"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_16090"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3391"/>
    <dbReference type="OrthoDB" id="891566at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016755">
        <property type="term" value="F:aminoacyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044038">
        <property type="term" value="P:cell wall macromolecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003447">
        <property type="entry name" value="FEMABX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02388">
        <property type="entry name" value="FemAB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51191">
        <property type="entry name" value="FEMABX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="372" mass="42251" checksum="8BDACAAB5BBD5F6D" modified="2015-07-22" version="1">MSLTLQPISREQHLAYIRSLPAASHCQIPAWADVKSEWRAENLGWFDADGRQVGAALVLYRQLPKVKRYLAYLPEGPVIDWYAPNLDAWLNPMLAHLKSQGAFSVKMGPPVIIRRWEAPTIKAGIADPDVKRLRDVNADVVEPRAFEVAERLRRMGWQQGEDGGAGFGDVQPRYVFQVPLAGRSLDEIFKGFNQLWRRNVKKAEKAGVEVVQGGLEHFGEWQRLYEITAERDKFRPRPQGYFERMWKVLNAEEPGRMRLYFALYQGECLAATTMLTVGGHVWYSYGASANHGREVRPSNAIQWQMMKDAHAAGAHVYDLRGIGDALVDSDHLFGLIQFKVGTGGQAAEYLGEWDYPLNKLLHKALDIYMSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6G6</accession>
    <name>A0A0F7N6G6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_12980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016322.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_12980"/>
    <dbReference type="EnsemblBacteria" id="AKH82988">
        <property type="protein sequence ID" value="AKH82988"/>
        <property type="gene ID" value="AA958_12980"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_12980"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2732"/>
    <dbReference type="OrthoDB" id="1902704at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="478"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="523" mass="52023" checksum="081E42432342FC28" modified="2015-07-22" version="1">MTHDGHGSEPRREERAGAVPPASDGAGPPPGGEPWWAQDPSPAAAAAESEDESTQQIRHLGNRPERPRPPGAPSAGGQPWPLPASPGTAGAPGAPAGPGALGGPEAAAATGHPGAAPQPLYGGPPQQPPTGPPPGAADDAAATQLIPPIAAAPQQRPGDDSDATQLIPSLPGPYEDPRPGAYDPPAAEPPPQPGAPPAQPPGRPPFAPPAFDEDSPRSRRHAAPVHTQFEGLFRDGPGGPGAPGGDPGATQRLPPVRPGAAPAGGPQPPYGAQQPGAHPAGPPPGPYGNGGPGGPGGPYYDDDDDRRGGIPRWAAIAIGTAACAAVGITAGWLLSSGDGDGDSAGGATPSASADQDPGGEDDGGKDDGGEKPVKDDPAKAQAEELDALLAESNDSRDAVISSVANIRECKALGKAAKDLRDAAGQRRDLVARLSDLSVDKLPSHEDLTRSLTDAWNASASADDHYAAWADAAKRGKGCGGGGNHLSAGNSASGEATAAKEEAAGLWNPIADKYGLTQRQATQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6H9</accession>
    <name>A0A0F7N6H9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_20950</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017535.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_20950"/>
    <dbReference type="EnsemblBacteria" id="AKH84250">
        <property type="protein sequence ID" value="AKH84250"/>
        <property type="gene ID" value="AA958_20950"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_20950"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4414"/>
    <dbReference type="OrthoDB" id="1866788at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519830" evidence="2">
        <location>
            <begin position="26"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH84250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="434" mass="45949" checksum="EB0FFFCBD9CC89D7" modified="2015-07-22" version="1">MRATRWIAFAAVVVALLAGCSDSGEDEENPGAKEGKRTGPSPSAEATPPGTQLDVPALYDTGRGWESTEEGTQLPLPRTGAVAVYWERPGEGGPDEYGFTVLDAATGEKRWSSVPVSPLESTSLPYIRATVDGKEYLALWSSGTTDDDAINRGKEVVAIDIFPADASGDGVRPVHVEVDGEGKVRDGGAGLLVQSGDDTVVAVDPATGDTTEYGVADQEPPADCPECDSSWQVKGLTDDGLLIGTSIDIDYNGFWVPGAWTAADLRPKGVAPGEPSRVQVISDDLLVVDWGQERNSEAIVWSAVDSSSGKTLATVRCEGDTTPGDHHLSANGRYLAHGGRVFDLEEGTGVCYERTDSTNAVEFQLATDEGVVYGNAIGSEGFISSEDPVQLDMRTGKIEEFDDVTIDFPFGDTAGFGLFWDEASRTMVAYPHAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6Q8</accession>
    <name>A0A0F7N6Q8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_13525</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016413.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_13525"/>
    <dbReference type="EnsemblBacteria" id="AKH83083">
        <property type="protein sequence ID" value="AKH83083"/>
        <property type="gene ID" value="AA958_13525"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_13525"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2846"/>
    <dbReference type="OrthoDB" id="1812124at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019660">
        <property type="entry name" value="Put_sensory_transdc_reg_YbjN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10722">
        <property type="entry name" value="YbjN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH83083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="185" mass="20274" checksum="A8C61697ACED7745" modified="2015-07-22" version="1">MAEAASTDGRAASTDTAAAGKVVEDTLREAGIAYESPAPGTYVVSLPGTRKLSTTCQLIVGRHSLSVNAFVIRHPDENEAGVHRWLLERNTRLYGVGFAVDRLGDIYLVGRLPLAAVTPKELDRVLGTVLETADGSFNRLLELGFATAIRKEYAWRTSRGESTRNLEAFTHLTRPERPEQPERPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6R6</accession>
    <name>A0A0F7N6R6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7 8">Pantothenate kinase</fullName>
            <ecNumber evidence="4 7 8">2.7.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Pantothenic acid kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">coaA</name>
        <name evidence="10" type="ORF">AA958_21370</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7 8">
            <text>(R)-pantothenate + ATP = (R)-4'-phosphopantothenate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16373"/>
            <dbReference type="ChEBI" id="CHEBI:10986"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29032"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.33"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7 8">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7 8">Belongs to the prokaryotic pantothenate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.33" evidence="4 7 8"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017588.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_21370"/>
    <dbReference type="EnsemblBacteria" id="AKH84325">
        <property type="protein sequence ID" value="AKH84325"/>
        <property type="gene ID" value="AA958_21370"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_21370"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4499"/>
    <dbReference type="OrthoDB" id="1793376at2"/>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00352"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004594">
        <property type="term" value="F:pantothenate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02025">
        <property type="entry name" value="PanK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00215">
        <property type="entry name" value="Pantothen_kinase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004566">
        <property type="entry name" value="PanK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006083">
        <property type="entry name" value="PRK/URK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10285:SF139">
        <property type="entry name" value="PTHR10285:SF139"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00485">
        <property type="entry name" value="PRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000545">
        <property type="entry name" value="Pantothenate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00554">
        <property type="entry name" value="panK_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 7 8" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PRK" evidence="9">
        <location>
            <begin position="97"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="102"/>
            <end position="109"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AKH84325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="324" mass="36462" checksum="CE86C89AF19E82F9" modified="2015-07-22" version="1">MASPTSTHSPSPYVDLSRAEWSALRDRTPLPLTAAEVERLRGLGDVIDLDEVREVYLPLSRLLNLYVGATHGLRDAVHTFLRGPGETAGPQAGTPFVIGVAGSVAVGKSTVARLLQALLARWPEHPRVELVTTDGFLLPNAELEARGLMARKGFPESYDRRALTRFVADVKSGKDEVTAPVYDHLTYDIVPGERLKVQRPDILIVEGLNVLQPALPGRDGRTRVTLADFFDFSVYVDARTEDIERWYAERFRKLRETAFQNPLSYFRRYAEVPEAEAMAYGRRNWRTINEPNLRQNIAPTRGRATLILRKGPDHKVQRLSLRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6Z7</accession>
    <name>A0A0F7N6Z7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_18300</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017135.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_18300"/>
    <dbReference type="EnsemblBacteria" id="AKH83836">
        <property type="protein sequence ID" value="AKH83836"/>
        <property type="gene ID" value="AA958_18300"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_18300"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3846"/>
    <dbReference type="OrthoDB" id="1558246at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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            <begin position="21"/>
            <end position="41"/>
        </location>
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        </location>
    </feature>
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            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="225"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="253"/>
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            <end position="296"/>
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            <end position="326"/>
        </location>
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            <end position="355"/>
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            <end position="530"/>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="530" mass="55148" checksum="AFC6D54350E669B2" modified="2015-07-22" version="1">MADKDQEAVPAPPRNVRVIMLGLMITMMLAMLDNLIVGTAMPTIVGELGGLNHLAWVVTAYTLAIAVSTPLWGKFGDLYGRKGIFMSSIVLFLIGSALSGMAQDMGQLIAFRAVQGLGGGGLIVGVMAIIGDLVPPRERGRYQGMMAAVMGIATIGGPLVGGTITDHLGWRWAFYINLPLGAVSLFVISAVLHLPKKRIKARVDYTGAALLSVGLTALVLVTSWGGTEYDWGSAQIIGLAVLGAAALAAFGWAETRAVEPIIPLRIFRNANFTLMNVIGFIVGFVMFGGVTFLPLFQQSVQGASATNSGLLLLPMMLPVMVVSLFVGRATTRTGRYKIYPIIGGAALIAGMYLLSTMDTGTSRLTSGIYMAVMGAGLGFMIQMSMLVGQNSLEMRDMGAGSSTITLTRTIGGSFGVALMGAIFSSRVADTMAEEAGPAGEKAAGSGGQLTPERIEQLPAQIKEAYLNAVSHGTHQVFLWGAAIAALAFLASWFVKEVPLRGAGPANDDAGSAGDAGPGSAQAEAEAPAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N764</accession>
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            <authorList>
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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            <dbReference type="Proteomes" id="UP000034283"/>
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    <sequence length="293" mass="31419" checksum="A801DADF374A0F7A" modified="2015-07-22" version="1">MNAANAAAGAQPRWIPPAERIRALARGELTPVTPRRAATVLLLRGTAPDGPWVYMLRRKTSMPFAAGAYAYPGGGVDPRDERPLSAAAWAGPSPARWAARLGVAEPEAQAVVCAAVRETFEEAGVLLAGASAAEVVADTTGADWEADRAALVARELGFADFLARRGLVVRTDLLGAWARWITPEFETRRYDTWFFVAALPEGQRTRNASTEADRAEWVRPAEAAEGYERGELVMLPPTISMLRGLRAFGSAAEALGAAGERDLSAVLVKARMEGDDVVLSAPGHEEFTRRLPS</sequence>
</entry>
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    <accession>A0A0F7N7H1</accession>
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                <person name="Albersmeier A."/>
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                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">CNQ-509</strain>
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    </reference>
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    </dbReference>
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            <dbReference type="EMBL" id="AKH82797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="444" mass="47758" checksum="23B8A13748EDC74D" modified="2015-07-22" version="1">MHEHRTQIFEVSTLYGAATLAAALDAGQFGPRAGARRILLAANNAAVPETAVQLSEMHGWTPVSARFDEVLDYNHEIRPHHPAAWHPKGGDVPLLQRLLRRAWNLGDGPLDLVVESVTAPPAKALVAIFADADVHVYADGLMSYGPTREKLPQHVACRVQRLLHLDLVPGLEPLLLTEYGVPAEVVPNAAFRAVLDEVTAATPAGDHGQREGEGDGAPTAVLLGQYLAALNILSQAEEEALHERMLRGAAAAGHRAVLFKPHPTAPARYSTVLQKAAADAGVTLTVQEEPMLAEALYGTLRPRLVVGCFSTAMLTAATLYGIPVARVGTDTLLERLTPYQNSNRIPVTIVDSVVPELGGPDRPARDATQLAGLLTAVGYCMQADNHARLRPGAQEWLAVYLDASTRPYFKRKRLTALRLPGGNLGRVPNARRALGKVRRALTKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N855</accession>
    <name>A0A0F7N855_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="7 8">
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        <lineage>
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    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83604.1"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_16855"/>
    <dbReference type="EnsemblBacteria" id="AKH83604">
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        <property type="gene ID" value="AA958_16855"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_16855"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3546"/>
    <dbReference type="OrthoDB" id="626204at2"/>
    <dbReference type="Proteomes" id="UP000034283">
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    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="112"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="273"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="310"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="340"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="366"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="411"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="484"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="21"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH83604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="513" mass="51443" checksum="8DAB1E4FAEDF127D" modified="2015-07-22" version="1">MTTSRAPAPGQEQGRRRRRLGLAVLALPALLASLELTVTNLALPAIGRDLGAGSTQLLWTVDIYAFLLAGSLITMGVLGDRVGRRRLLLYGAAGYGAASLLAAYAVNAEMLIAARALMGVAGATLMPSTLALAAALFPGPRERTTAIGVIVASVSGGTAIGPLVGGWLLERFWWGSAFLLGVPVMAVLLVLLPVLLPESRGPAGRRVDVLSSLLSLAAVLPVVYGLKQIAAEGAGALPVAAVAAGVLVAVAFVRRQRALADPFVDLRLFADRTLATAAATLAAGIFVLWGSNYALAQYLQLVEGLSPLDAGLWTAPSALGVIAGSTLAPRLARRYEPARIIAAGLALSAAGYGVLTQAGGAHALPVLVTGAVIVSAGLGPMMALATDMVVGAAPPERQGAAAAISSTAPQLGGALGIALLGSVITAVYRGRTDGAVPEGVPADAAGAFEDDLSATVTAAERLPGPAGDALLGAARGAFETGFQVAAGVCAALTVATAVLVARAGVRGKRRVSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N860</accession>
    <name>A0A0F7N860_9ACTN</name>
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        <submittedName>
            <fullName evidence="10">NADH dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AA958_20765</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Membrane</location>
            <topology evidence="1 5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_20765"/>
    <dbReference type="EnsemblBacteria" id="AKH84221">
        <property type="protein sequence ID" value="AKH84221"/>
        <property type="gene ID" value="AA958_20765"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_20765"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4379"/>
    <dbReference type="OrthoDB" id="1274678at2"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="NADHpl_OxRdtase_5_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003945">
        <property type="entry name" value="NU5C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001516">
        <property type="entry name" value="Proton_antipo_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42829">
        <property type="entry name" value="PTHR42829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Proton_antipo_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01974">
        <property type="entry name" value="NDH_I_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="76"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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    <feature type="transmembrane region" description="Helical" evidence="7">
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    <feature type="transmembrane region" description="Helical" evidence="7">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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        </location>
    </feature>
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        <location>
            <begin position="500"/>
            <end position="521"/>
        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
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            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
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            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AKH84221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="681" mass="69385" checksum="4FAD8A132C05DE0E" modified="2015-07-22" version="1">MTTTTLAALVPLLPFLGAVAGLFLGRRSPGMVQPLAVLPTVTAAVLAALVAARQGGDEPVTAATELTPTGSVPIDLALHLDGMAVLVAVLVGVVASCVQIYSTGYLRDDPRYPSYAALVSLFTAAMFLVVYSGDLMVLLVGWEIMGICSYFLVGHYWDTEVARAASLKAFLVTKLGDVPFLIGIFALASEAGTFRISGIVTAAGSGDGLAHPTVIALLLLAGVAGKSAQFPLHTWLPDAMAGPTPVSALIHAATMVAAGVYVVARLLPVFAASAAALVVLAVMAAVTMVGSALAALAQDDIKRVLAYSTVGQLGYMTGALAAGSRDAAVFHLLSHGAFKALLFLAAGVVIHAAGTNSLAAMARMGGLRHRVPDAYWTMTAALLALAAIPPFAGFFSKEAVLGAAEAAITGHGATGGGIPAAAAWTVLVAGLAAALLTAAYAARLWLLAFHGRGEPVPDHGRRPVVMNAVLWLLFVPTLAFGLSVWTLPDWLGDHSLTPTLATAVLGTGLALVGMMATYAAWKQTAGLAARVPAGAVTAHPDAEPALTEVEAEATHETVYGSPSDEGTAASGAAPDGTATDPGRILLGAALYRHAARGFHVDALYAVLFVRPVRAAARLVRFLDREVVDTYVRGAGTAPRLLGAAVRRAQTGNVQSYLSALLGGALVLAVAVVVATTSVTGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N889</accession>
    <name>A0A0F7N889_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribonuclease VapC</fullName>
            <shortName evidence="6">RNase VapC</shortName>
            <ecNumber evidence="6">3.1.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Toxin VapC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">vapC</name>
        <name evidence="8" type="ORF">AA958_17075</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Toxic component of a toxin-antitoxin (TA) system. An RNase.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the PINc/VapC protein family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="6"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016943.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_17075"/>
    <dbReference type="EnsemblBacteria" id="AKH83639">
        <property type="protein sequence ID" value="AKH83639"/>
        <property type="gene ID" value="AA958_17075"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_17075"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3590"/>
    <dbReference type="OrthoDB" id="1968541at2"/>
    <dbReference type="Proteomes" id="UP000034283">
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    </dbReference>
    <dbReference type="GO" id="GO:0000287">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00265">
        <property type="entry name" value="VapC_Nob1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="PIN_dom"/>
    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF01850">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0800">Toxin</keyword>
    <keyword evidence="1 6" id="KW-1277">Toxin-antitoxin system</keyword>
    <feature type="domain" description="PINc" evidence="7">
        <location>
            <begin position="4"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH83639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="137" mass="14742" checksum="843A9BB6D9AD73E5" modified="2015-07-22" version="1">MGRVILDTGVLAAVDRGRVELAKLLRARDDDITIAAVTAAELLQGVELAADELTTRRRQGFVDAVLAIVPVDDYTLDVARVHARLLAYTRKLGKPRGAHDLIIASTAIATNRTVMTTDAHAKFDELPGVAAEMFPVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8A4</accession>
    <name>A0A0F7N8A4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glucarate dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_24135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018042.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_24135"/>
    <dbReference type="EnsemblBacteria" id="AKH84790">
        <property type="protein sequence ID" value="AKH84790"/>
        <property type="gene ID" value="AA958_24135"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_24135"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5086"/>
    <dbReference type="OrthoDB" id="951991at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
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        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
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        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034593">
        <property type="entry name" value="Mandelate_racemase_DgoD-like"/>
    </dbReference>
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        <property type="entry name" value="PTHR48080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF54826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MR_MLE" evidence="1">
        <location>
            <begin position="167"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="422" mass="44484" checksum="C84A1100B249D022" modified="2015-07-22" version="1">MRIREITVTPVAFRDPPLLNAAGVHEPWALRSVVEVVTDDGLSGLGESYGDASHLDRLRAAAEALTGADAGHHHDLYARVAASVGTGVFTDQHGLTGAGSNGKTVDSVFSPFEVACLDIVGKATGRRVADLLGGPVRDAVPYSAYLFYKWAGHPDAPEDRFGAALDPDGIVAQARLLVGEYGFRSLKLKGGVFPPGEEIAAVRALTDAFPGLPLRIDPNAAWTPETSVRVGTELAGALEYLEDPAPGIEGMAEVAAKVPMPLATNMAVVTHAHLPPAIAHRAIGVLLLDHHYWGGLLKSAQVAALCATFGIGLSMHSNSHLGISLAAMTHLAAATPNLDHSCDTHTPWLTVRDGQDVIAPGALAFAGGAVPLPPGPGLGVELDRDALAVLHEQYERCGVRRRDDTAYMRRFHPGFAPARARW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8K4</accession>
    <name>A0A0F7N8K4_9ACTN</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_21525</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
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        </lineage>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AKH84351">
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        <property type="gene ID" value="AA958_21525"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_21525"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4532"/>
    <dbReference type="OrthoDB" id="1986439at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="94"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH84351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="173" mass="17494" checksum="D3D66B233685E5A0" modified="2015-07-22" version="1">MSQPYQQQPGPGAPGQQPYGAPPPYAQPPAASGNTGLAVGVGIVAMIVGAVIYGAIMRASGGDAGEYTLYAYPAAAAGILVGLAFGKLGGRNPALPFVAIVLGILGAIMGQFLGYAMLINHWTDGQIGIATAFTDEFDLLKEAFKEDFDALVAAMYAVGGAAGFALTKRLGNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N934</accession>
    <name>A0A0F7N934_9ACTN</name>
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        <recommendedName>
            <fullName evidence="1">DUF402 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_22650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_22650"/>
    <dbReference type="EnsemblBacteria" id="AKH84536">
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        <property type="gene ID" value="AA958_22650"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_22650"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4765"/>
    <dbReference type="OrthoDB" id="1473648at2"/>
    <dbReference type="Proteomes" id="UP000034283">
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="DUF402"/>
    </dbReference>
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        <property type="entry name" value="FomD-like_sf"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159234">
        <property type="entry name" value="SSF159234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF402" evidence="1">
        <location>
            <begin position="121"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="251" mass="28034" checksum="46B762E97B2AE257" modified="2015-07-22" version="1">MHGPDATLDSDKNVSGGRWTPGDHILWRYRAHGPGAAGTACADGTDSAGDAGRLGRTVAVCRPVTVVRDDAETLAVWVAPDTECVRPVLADGTELHREPLATRYTKPHRPFRTRWFGAGVLKLARPGEPWSVWLFWEIDWTFKSFYVNLEAPRVRWAGGVDSEDHYLDLVVRPDRSWEWRDEDEFAAAQRAGLMSAARAAAVRDAGRRAVDAIGAWGPPFSEGWERWRPDPKWTVPLLPADWDRTPARLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N937</accession>
    <name>A0A0F7N937_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_19045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017239.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_19045"/>
    <dbReference type="EnsemblBacteria" id="AKH83944">
        <property type="protein sequence ID" value="AKH83944"/>
        <property type="gene ID" value="AA958_19045"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_19045"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3998"/>
    <dbReference type="OrthoDB" id="498436at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="290"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="319"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="349"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="380"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="410" mass="41519" checksum="2C168C09996BC54F" modified="2015-07-22" version="1">MSTALTPRHARHTAGLARGIYLPRTADAAAFAMSTYGIPLLVLHTTGSAALTGLAFALEWIPRLAAFGWAGSVVDQRGASVVFCLASLGRALALAAGAVLLHVHPSGTVASTTVTALAASTGVLTEFSYIAAETAGGAAGRRAGPRAHRVQSVLLGIDQSATLAGPALAGVLLLAGAPQMLAVVAALSLLAALLALHTPPSPVTPARAPKDRAGAGLVTGWRTIRSLPALGWLVTGLTLSNLAIGFLQAAAPVIVVKHFGQSTTAVGLLWSTAAATLASVALCRFAIDRLGLWTVGAACAALASLACLAAAQAPTYRSYLILIAILMAAEGGMTVVLRTLRARLIPTAVFGSTLAVTILILLLPFPLAGVLTALTPPDDLGHVITACAAIQALGLLLAFTRLRTDPALHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9A2</accession>
    <name>A0A0F7N9A2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_20060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017388.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_20060"/>
    <dbReference type="EnsemblBacteria" id="AKH84098">
        <property type="protein sequence ID" value="AKH84098"/>
        <property type="gene ID" value="AA958_20060"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_20060"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4226"/>
    <dbReference type="OrthoDB" id="1478362at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="22"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="276" mass="30735" checksum="A6B81919DE4DB0F3" modified="2015-07-22" version="1">MAQRPRELTPDRSARHLFGFEMRRCREHAGMSLEGLAEVVKYSRSHLARIEVAAYMPPPDLAAALDAAFGTDGIFQRLYALARHEVHPDKYRRRMELEAQARAIGEYAGVLVPGIVQTEDYARAVFRAQKPRATGDQIEEMVTARMGRQALLASDRPPEFSAVLDEAVLRRPVGGPGVMGEQLDRLHKLTHTETTVVQVLPFVHGEHALLGGSLALFTLERGTFVAYEESIGTGQLLEDPELVDARRRAYDLLRAYALSPKDSAELIQSIKETFST</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9A8</accession>
    <name>A0A0F7N9A8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cyclodehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_19625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017312.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_19625"/>
    <dbReference type="EnsemblBacteria" id="AKH84019">
        <property type="protein sequence ID" value="AKH84019"/>
        <property type="gene ID" value="AA958_19625"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_19625"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4135"/>
    <dbReference type="OrthoDB" id="735222at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022291">
        <property type="entry name" value="Bacteriocin_synth_cyclodeHase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027624">
        <property type="entry name" value="TOMM_cyclo_SagD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003776">
        <property type="entry name" value="YcaO-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02624">
        <property type="entry name" value="YcaO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03882">
        <property type="entry name" value="cyclo_dehyd_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03604">
        <property type="entry name" value="TOMM_cyclo_SagD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51664">
        <property type="entry name" value="YCAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YcaO" evidence="1">
        <location>
            <begin position="279"/>
            <end position="662"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="662" mass="70337" checksum="112171FF10E6A2CC" modified="2015-07-22" version="1">MTATAAEQTETVRAGARGPFEAARTWLADALRSRWAAGEGLPPTREPGVPLPLVVPLGAADTLHPGRDPWPDERPGATVHLTSRAVLVGPWGAGPDPVAGGPPAPRPACGRCLAMRWQRLRTRSEREALEGGFAPEGGAAWPVLTDHAADAVWAVCRAVAGRRSPDGLAQVTRVDLGTLALATFPLLPEPLCPACVTPADDAPEHGRMYLAPTPKPAPDVYRVTPLAALDLPEAALANPVCGALGSTTHLNPASTTTAPISGSAFVRGYAGLNDVTFSGQADAYATSRTLAYLEGLERYAGTHARRGLRPVTASLGELAAEWGENAVVDPRRTGLYSPETYRDDPMVDPFDPARPIPWIWGHCLRDDHPVLVPARLVHYSAGLPSDNFVFECSNGCATGGSLAEAALYGLLELIERDAFLLAWYGRAPLTRVDPRPAGDPRVRGMLDRAALLGYEVRAFDTRSDLGIPVITAVAVREDGGDGLLSFGAAAALDPAAALTGALSEVLTYIPHLPYQVAERRAELEEMAEDFGRVRQLKDHAQLYGLPRMAAHARDFLTGDPALPLADVYADWAQVRPATLDLRDDLRLLVDALAVHGYDAVAVDQTTPEQRAVGLRTVATLAPGLLPLDFGWHRQRALGMPRLLAAASASTGGGLRTVPHPFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9B2</accession>
    <name>A0A0F7N9B2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">50S ribosomal subunit assembly factor BipA</fullName>
            <ecNumber evidence="2">3.6.5.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">GTP-binding protein BipA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">bipA</name>
        <name evidence="4" type="ORF">AA958_23135</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>GTP + H2O = GDP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="2">Binds to ribosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. BipA subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="2"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017873.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_23135"/>
    <dbReference type="EnsemblBacteria" id="AKH84616">
        <property type="protein sequence ID" value="AKH84616"/>
        <property type="gene ID" value="AA958_23135"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_23135"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4877"/>
    <dbReference type="OrthoDB" id="143460at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03710">
        <property type="entry name" value="BipA_TypA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00849">
        <property type="entry name" value="BipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035651">
        <property type="entry name" value="BipA_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042116">
        <property type="entry name" value="TypA/BipA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006298">
        <property type="entry name" value="TypA_GTP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF8">
        <property type="entry name" value="PTHR42908:SF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01394">
        <property type="entry name" value="TypA_BipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="2" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Tr-type G" evidence="3">
        <location>
            <begin position="5"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="17"/>
            <end position="22"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="137"/>
            <end position="140"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH84616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="628" mass="68519" checksum="0B2F5B4705413854" modified="2015-07-22" version="1">MPTRQDIRNVAIVAHVDHGKTTLVDAMLKQAGAFAEHQLQSVDDRVMDTGDLEREKGITILAKNTAVKYHPKSGDPVVINIIDTPGHADFGGEVERGLSMVDAVVLLVDASEGPLPQTRFVLRKALQARLPVILCINKTDRPDSRISEVVDDTYDLFLDLDADEEQIEFPIVYACARDGVASLTQPEDGTVPADSDSLEPFFSTILDYVPAPAYDEGAPLQAHVTNLDADNFLGRIALLRVEQGELKKGQTVAWIKRDGTVQNVRITELMMTDALTRRPAQLAGPGDICAVAGITDIMIGETLADPENPVALPLITVDEPAISMTIGTNTSPLVGKGVGGGKSKGHKVTARLVKDRLDRELVGNVSLRVLPTERPDAWEVQGRGELALAILVETMRREGFELTVGKPEVVTKEIDGKVHEPVERMTIDAPEEHLGAITQLLAARRGRMETMTNHGSGWVRMEFVVPSRGLIGFRTEFLTQTRGTGIAHSIFEGHEPWFGELRTRSSGSLVADRTGAVTAFAMTNLQERGTLFVEPGTEVYEGMIVGENSRSDDMDVNITKEKKLSNVRSSTADIAESIVPPRKLSLEQSLEFCRDGECVEVTPDTVRIRKVVLDGRERARAASRAKHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9E2</accession>
    <name>A0A0F7N9E2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phytanoyl-CoA dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_20330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017432.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH84143">
        <property type="protein sequence ID" value="AKH84143"/>
        <property type="gene ID" value="AA958_20330"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_20330"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4282"/>
    <dbReference type="OrthoDB" id="1070946at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH84143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="263" mass="29893" checksum="4986714EBCA300B4" modified="2015-07-22" version="1">MVTSNGYVLDESPRRLGELRPVPDAERDDREALWARLRREGYLWLRGVLDPGGVREFRRFYFAHVDPELPRGDQRAALFGRVVPGAEYADFCAQPAVRDWYAWFLGGETFLHRRKILRHTRPGEAGVGTATQAHYDLVYLREGTDRVLSSWIPLGDCPVELGGLVYLERSHVRVLAAEAAGTLKRPAASITADLPALAEEYDARWLLADYAAGDMVVHSAHMVHASLDNTAATYRLSTDIRYQRADEPIDWRWQEHWHDLDGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9G7</accession>
    <name>A0A0F7N9G7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_23510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017936.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_23510"/>
    <dbReference type="EnsemblBacteria" id="AKH84681">
        <property type="protein sequence ID" value="AKH84681"/>
        <property type="gene ID" value="AA958_23510"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_23510"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4957"/>
    <dbReference type="OrthoDB" id="991598at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.150.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018766">
        <property type="entry name" value="Zinicin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042271">
        <property type="entry name" value="Zinicin_2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39420">
        <property type="entry name" value="PTHR39420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10103">
        <property type="entry name" value="Zincin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03624">
        <property type="entry name" value="TIGR03624"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="463"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="509" mass="52718" checksum="18D203C19DA068D2" modified="2015-07-22" version="1">MSDTPFGFGPPKEPDDDGEGDDKGARKGDGDRSGRDPFGFGGAGSDPQNPFAAIFGSLGGQGGAMGPQDLGAAFQQLGQMLSYEGGPVNWDMAKDIARQTVAQGAAEGTSQAGGSGGESKDASVGAAERKAVEESVRLADLWLDGATSLPSGSGAALAWSRAEWVEATLPVWKELVDPVAERVGAAMGGVLPEEMQAMAGPLIGMMRSMGGAMFGTQIGHAVGVLAGEVVGSTDIGLPLGPAGKAALLPVNIKRFSEGLGVPQDEVRLYLALREAAHQRLFAHVPWLRSHLFGAVEGYARGIKVDTSKLEDLVGQVDIERPEQLQEALQQGMFQPEDTPEQKAALARLETALALVEGWVDAVVHAAAEPHLDAPSLNSLREALRRRRATGGPAEQTFATLIGLELRPRRLRDASRLWASLADARGVDGRDALWAHPDMLPTAGDLDDPDGFVHSEQADFSELEKLLGSGGDAESGDSGGKDAPDGKGGPGGQDGGSGNGKGDDKGDGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9R7</accession>
    <name>A0A0F7N9R7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_15760</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016734.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_15760"/>
    <dbReference type="EnsemblBacteria" id="AKH83422">
        <property type="protein sequence ID" value="AKH83422"/>
        <property type="gene ID" value="AA958_15760"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_15760"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3322"/>
    <dbReference type="OrthoDB" id="1828250at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032688">
        <property type="entry name" value="ABC2_membrane_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12679">
        <property type="entry name" value="ABC2_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH83422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="280" mass="27881" checksum="C30C61A443038ED3" modified="2015-07-22" version="1">MREGGLGRRGRRHGPGARAVCGGVRDTGYAARAEWTKLRTVPSTWWLLLAVAAVTVAVGAGAVSGLSTAHCPPAGCREDVVRTSLVGVWAGQAAVAVLASLAFTAEYGAGTIRTTFTAVPGRLRVLAAKSAVVGAAVLVAGGAGVLGALLAGRALVPAGFTAYDPGAGPVLRAGFGTALYLVLVALLALGLGAALRDTAGAVAACLGVLYASPLVAGMLSDPEWVERFQRYGPASAGLAVQSTVDTAELPIGPWAGLGVLAAWSAAALALGAAVLHRRDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9W4</accession>
    <name>A0A0F7N9W4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">30S ribosomal protein S5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rpsE</name>
        <name evidence="12" type="ORF">AA958_21260</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.</text>
    </comment>
    <comment type="function">
        <text evidence="7">With S4 and S12 plays an important role in translational accuracy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.</text>
    </comment>
    <comment type="domain">
        <text evidence="7">The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 9">Belongs to the universal ribosomal protein uS5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018834831.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_21260"/>
    <dbReference type="EnsemblBacteria" id="AKH84303">
        <property type="protein sequence ID" value="AKH84303"/>
        <property type="gene ID" value="AA958_21260"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_21260"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4477"/>
    <dbReference type="OrthoDB" id="1505038at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01307_B">
        <property type="entry name" value="Ribosomal_S5_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000851">
        <property type="entry name" value="Ribosomal_S5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005712">
        <property type="entry name" value="Ribosomal_S5_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005324">
        <property type="entry name" value="Ribosomal_S5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013810">
        <property type="entry name" value="Ribosomal_S5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018192">
        <property type="entry name" value="Ribosomal_S5_N_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13718">
        <property type="entry name" value="PTHR13718"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00333">
        <property type="entry name" value="Ribosomal_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03719">
        <property type="entry name" value="Ribosomal_S5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01021">
        <property type="entry name" value="rpsE_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00585">
        <property type="entry name" value="RIBOSOMAL_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50881">
        <property type="entry name" value="S5_DSRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 7 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="S5 DRBM" evidence="11">
        <location>
            <begin position="33"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="11"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AKH84303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="200" mass="20416" checksum="AF9EDBB0BCAE429F" modified="2015-07-22" version="1">MAGPQRRGGGAGGGERRDRKGRDGGNAADKTAYVERVVAINRVAKVVKGGRRFSFTALVVVGDGDGTVGVGYGKAKEVPAAIAKGVEEAKKHFFKVPRIQGTIPHPIQGEEAAGVVLLKPASPGTGVIAGGPVRAVLECAGIHDVLSKSLGSSNPINIVHATTAALKGLQRPEEIAARRGLPLEDVAPAAMLRARAGVNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NA64</accession>
    <name>A0A0F7NA64_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pyridine nucleotide-disulfide oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_16845</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NADH dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016906.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_16845"/>
    <dbReference type="EnsemblBacteria" id="AKH83602">
        <property type="protein sequence ID" value="AKH83602"/>
        <property type="gene ID" value="AA958_16845"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_16845"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3544"/>
    <dbReference type="OrthoDB" id="403436at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006116">
        <property type="term" value="P:NADH oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045024">
        <property type="entry name" value="NDH-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706">
        <property type="entry name" value="PTHR43706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="2">
        <location>
            <begin position="3"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH83602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="392" mass="40898" checksum="9CA2A100DFB74B0C" modified="2015-07-22" version="1">MNHVVIIGGGFAGVWSAAGAALARGDADLRITLIAPGDRLVLRPRLYEPEPDRATVALDRILGPIGVAHVRATVSTIDTERRVVVADGTEIGYDRLVLASGSRLVPPAGLPGAERLFDIDTLAGARRLTGHLRGRDGYAAVVVGAGFVGLEAATELAARGRVLLVDTAETVGEPLGPGPRAAIEAALDELGVERRLGTSVTEVGDGYAVLSGGERVDADAVVWSTGLRAQELTRQLVADPGELDHLGRVPVDEWLRALPEVFAAGDTAAAPYDAEHTVMQACQHATPLGKVAGYNAAADLLGVPPRPFTPAPYVTCLYLGGAGGVFTRGWDRAVMATGADGAFVKEQINGYIHPPVDDAGEILAAADRVCIDLPFFPREDEPEAPAAVRSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NA70</accession>
    <name>A0A0F7NA70_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Adenine methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_28040</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018679.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_28040"/>
    <dbReference type="EnsemblBacteria" id="AKH85445">
        <property type="protein sequence ID" value="AKH85445"/>
        <property type="gene ID" value="AA958_28040"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_28040"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5910"/>
    <dbReference type="OrthoDB" id="2030110at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000179">
        <property type="term" value="F:rRNA (adenine-N6,N6-)-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001737">
        <property type="entry name" value="KsgA/Erm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020596">
        <property type="entry name" value="rRNA_Ade_Mease_Trfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020598">
        <property type="entry name" value="rRNA_Ade_methylase_Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727">
        <property type="entry name" value="PTHR11727"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00398">
        <property type="entry name" value="RrnaAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00650">
        <property type="entry name" value="rADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01131">
        <property type="entry name" value="RRNA_A_DIMETH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51689">
        <property type="entry name" value="SAM_RNA_A_N6_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="rADc" evidence="6">
        <location>
            <begin position="62"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH85445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="299" mass="32915" checksum="39E5DD8722A7211C" modified="2015-07-22" version="1">MSARADSDTNRRADARATTGGNARTNRRRGSPEGGRDTGSRGGGSRSRSLSLSQNFLAGPAVAQRVVRLAAPEAGAGLVVEVGAGTGMLTEALAPHCRELIAYEIDRRLLPDLRARLAAHPHVRVVGQDFLTARPPREPFAVAGNVPYARTSAIVDWCLRAPRLESATFVTQLEYARKRTGDYGRWSLLTVRTWPWHEWRLRGRVPRESFRPVPRVDSAVLRIDRRGEPLLPRGEEAAYRRLVETGFGGAGGTLYASLRRAGYPTARLTTAFRRADLSKTTVVAYATPAQWLTLHETLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAN2</accession>
    <name>A0A0F7NAN2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">1,2-oxophytodienoate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_17825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017059.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_17825"/>
    <dbReference type="EnsemblBacteria" id="AKH83757">
        <property type="protein sequence ID" value="AKH83757"/>
        <property type="gene ID" value="AA958_17825"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_17825"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3755"/>
    <dbReference type="OrthoDB" id="1064766at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045247">
        <property type="entry name" value="Oye-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893">
        <property type="entry name" value="PTHR22893"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidored_FMN" evidence="1">
        <location>
            <begin position="4"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="367" mass="38747" checksum="E7A55C7BB5135F89" modified="2015-07-22" version="1">MTNKIFEPVRIGRLDLPHRLAMAPMTRSRASADGGLVSELTAEYYEQRAGAALIITEGTQPCVRGQGYIQTPGIHTAAQVAAWRKVTDRVHAAGGRIFLQLLHAGRVGHPYLYPDGGLPEAPSALASGESLFTNDQGLLPHPVPRELTADDIGEIVRDFAAGARGAIEAGFDGVELHGANGYLIHQFLADGANRRTDAYGGPVENRIRFAVETVRAVSEAIGADRTALRISPGNGANGVTESDAADVYAALVAALAPYPLAYLHLLEGTPELRGVTEQVRRGWAGPLMLNSMHHGGGDPVEDAERLLAAGTADIVALGARWLANPDLMARVRAGGPYNEADEATYYGGDHRGYTDYPALAPPAPAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAR1</accession>
    <name>A0A0F7NAR1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AA958_29040</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Nitrate/nitrite porter (TC 2.A.1.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018851.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_29040"/>
    <dbReference type="EnsemblBacteria" id="AKH85620">
        <property type="protein sequence ID" value="AKH85620"/>
        <property type="gene ID" value="AA958_29040"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_29040"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6118"/>
    <dbReference type="OrthoDB" id="1217595at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
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</entry>
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                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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</entry>
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                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        </location>
    </feature>
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            <begin position="1"/>
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        </location>
    </feature>
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            <dbReference type="Pfam" id="PF04149"/>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
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    </evidence>
    <sequence length="97" mass="10214" checksum="03612FB7CC4442D6" modified="2015-07-22" version="1">MKMAHTHGTNDAHRTGAPGGGQVYNGMPARELGTDGWDKPWSGPNGDACVEAKRLADGRVALRQSTADDGPALIYTADEMRAFLAGIKNGDADFLLS</sequence>
</entry>
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    <accession>A0A0F7NBK5</accession>
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                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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    <dbReference type="EnsemblBacteria" id="AKH84087">
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    </dbReference>
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        <property type="entry name" value="ASST-like"/>
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        <property type="entry name" value="Arylsulfotran_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519467" evidence="1">
        <location>
            <begin position="33"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="511" mass="55202" checksum="F1E5B85A1676C1DF" modified="2015-07-22" version="1">MTRLPRTYATFMLCGATVAALTAAAPATGTAAAEQAAPGSTPAPGPAADQAAVVDQAAVDGGAPPGLDVLKRGEGMAPGLLFLTPQGRHETPRGPQIVDDRGRPVWYHRIPTGFVAADFQVEEYRGEKVLTWWEGESSPTGTGSGTGYIADENYDVIATVRTPDPGERTDFHEFRLTPDGTALILSYRDEPYDLTPVGGPKDGQVLDYVVQEIDIATGEKVMDWHSLDHIPITDSDRRFDAGMPGPFPYLHLNAVSLDRDGDLLFSGRETSTIYKVDRETGEIVWRLGGKRSDFRLGAGARTIGQHNIEPAGENTYRVFDNQNMGSPGYESRVAWLRIDERRMTAELVRQQVHPDRLTTGLEGNSQALPNGNTFVSWGSPSGRISEFSPSGRLVFDSALPEDISSYRGYRAPWKSTPDTAPEVGVNDAGTAVEAVWNGATEVSDWRVLGGETASGLRPVARAGWKGLDTEVRLPPEARDIDYVKVQGLDARGRVIGSSPVEAVEPAASRHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBR0</accession>
    <name>A0A0F7NBR0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MazG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_20380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017441.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_20380"/>
    <dbReference type="EnsemblBacteria" id="AKH84152">
        <property type="protein sequence ID" value="AKH84152"/>
        <property type="gene ID" value="AA958_20380"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_20380"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4292"/>
    <dbReference type="OrthoDB" id="1978527at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd11533">
        <property type="entry name" value="NTP-PPase_Af0060_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044548">
        <property type="entry name" value="AF0060_NTP-PPase_MazG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004518">
        <property type="entry name" value="MazG_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03819">
        <property type="entry name" value="MazG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MazG" evidence="1">
        <location>
            <begin position="32"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="104" mass="11740" checksum="A1CB7C15204DC1B0" modified="2015-07-22" version="1">MRDTWETIDRLVEWLDAESGVSPEMARLLRVLKISEEAGEVAEAIHGVTGSNPRKGNSHTWDDVQAELCDVIFTSMVALRTLTPEAEKIFAERLHHVAERSLNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBT8</accession>
    <name>A0A0F7NBT8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_31225</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019173.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_31225"/>
    <dbReference type="EnsemblBacteria" id="AKH85945">
        <property type="protein sequence ID" value="AKH85945"/>
        <property type="gene ID" value="AA958_31225"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_31225"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6598"/>
    <dbReference type="OrthoDB" id="1123553at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="3" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="423"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="307"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="356"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="397"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="3">
        <location>
            <position position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH85945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="517" mass="51608" checksum="D61E27FC7635774E" modified="2015-07-22" version="1">MDLRTALLLPGQGAYRPGAFAGPVSAPVAELLAVVDTVAAEFGHDPISPLLTDADAADGRRLAETDPFALQLAIYAAALVYAREVDLRAPADVVLGHSMGEMAAAAHAGCFTAADGARIAAHRARALEHGAAGTGGMLALTLPARRATALLAAAELPGARLAVVNAPRHVVVSGPGDALGRLAALADVLGVRVVRLTAPYPFHNPLLATAQAEFAAAIEGIPERPAQRRLYSPALGGLVEDDTDVKASLIAAVTRPVDFLAALRELQTYGLESVVECGRAGLGELVRQAVGCGTQTADRWLATGTAEGSAAPVATPTASPVPDPGAGAPVPAPVAWEVPAAAIPVAEPAPVPVPATAPAAPDSAAAGPAARVPGSAPGRVTESAASGRAAGPAIPSAPPTAAVPPPAAAGPGPLPAPSPAGPAAGGGVLAALQQVYADRLGYPVEAMDPDADLEGDLGIDSLKRMEVLSTLIDRFGLHHVADDTRFALQSTLGDLARLIDETGRTTGPAAAALRADG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NC32</accession>
    <name>A0A0F7NC32_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DAO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_31820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019273.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_31820"/>
    <dbReference type="EnsemblBacteria" id="AKH86045">
        <property type="protein sequence ID" value="AKH86045"/>
        <property type="gene ID" value="AA958_31820"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_31820"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6720"/>
    <dbReference type="OrthoDB" id="1726412at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="1">
        <location>
            <begin position="4"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="407" mass="42055" checksum="4F5C203970704AF8" modified="2015-07-22" version="1">MTRRIVIVGAGIVGSSLARELAGRDGCHVTVLDRAPAGRLYGSTGHAPGYVGVLGEAPVLTELARATVRIYRGLTDDYDGTGGGRERAGAGFEETGCLEVATTPAAYETLQGRAAVAQTAGLAARLVGPEEAAALAPRLVDPDTAVAGLHFPGDGTARAGLLTAVQRRRAEARGAEFADGAEATGLEIRAGRVHGVWLADGTLVPADDTVLASGIWGPLLAARAGVDLPLTPVSHPYVYGGPRPARHPRGPFVRWPEHHAYARDHGDRDGIGTYDHDLRPVAPADLGVRAEEPWPGEPFDGAVAAALALLPPAHRFAPAVRLNGVFSVTPDNLPLLGPFTGLPGLWSATAIWVTHAAGAAAALAEAMDGGEPGAGLAALAPDRFAGEPAGELRRRALRHYRDIYAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCC0</accession>
    <name>A0A0F7NCC0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">2-phospho-L-lactate guanylyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_25750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018304.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_25750"/>
    <dbReference type="EnsemblBacteria" id="AKH85058">
        <property type="protein sequence ID" value="AKH85058"/>
        <property type="gene ID" value="AA958_25750"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_25750"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5424"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH85058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="67" mass="7137" checksum="9CE70FB4FD7B2A8D" modified="2015-07-22" version="1">MQATAFTYDPQTGSGSVLLDDGTPLPFDGAAFAAGGLRLLRPGQRVRIETEGAGEERRIVLVTLQTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCL4</accession>
    <name>A0A0F7NCL4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 10">Purine nucleoside phosphorylase</fullName>
            <ecNumber evidence="6 10">2.4.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Inosine-guanosine phosphorylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">AA958_22175</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. Cleaves guanosine, inosine, 2'-deoxyguanosine and 2'-deoxyinosine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>a purine 2'-deoxy-D-ribonucleoside + phosphate = 2-deoxy-alpha-D-ribose 1-phosphate + a purine nucleobase</text>
            <dbReference type="Rhea" id="RHEA:36431"/>
            <dbReference type="ChEBI" id="CHEBI:26386"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57259"/>
            <dbReference type="ChEBI" id="CHEBI:142361"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Purine metabolism; purine nucleoside salvage.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the PNP/MTAP phosphorylase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.1" evidence="6 10"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017713.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_22175"/>
    <dbReference type="EnsemblBacteria" id="AKH84452">
        <property type="protein sequence ID" value="AKH84452"/>
        <property type="gene ID" value="AA958_22175"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_22175"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4670"/>
    <dbReference type="OrthoDB" id="1364220at2"/>
    <dbReference type="UniPathway" id="UPA00606"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004731">
        <property type="term" value="F:purine-nucleoside phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09009">
        <property type="entry name" value="PNP-EcPNPII_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011269">
        <property type="entry name" value="PUNP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011268">
        <property type="entry name" value="Purine_phosphorylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018099">
        <property type="entry name" value="Purine_phosphorylase-2_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11904">
        <property type="entry name" value="PTHR11904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000477">
        <property type="entry name" value="PurNPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01697">
        <property type="entry name" value="PNPH-PUNA-XAPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01698">
        <property type="entry name" value="PUNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01240">
        <property type="entry name" value="PNP_MTAP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PNP_UDP_1" evidence="12">
        <location>
            <begin position="30"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphate binding" evidence="11">
        <location>
            <begin position="88"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>a purine D-ribonucleoside</name>
            <dbReference type="ChEBI" id="CHEBI:142355"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>a purine D-ribonucleoside</name>
            <dbReference type="ChEBI" id="CHEBI:142355"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000477-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AKH84452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="268" mass="28034" checksum="4018DD6FE91FE9A5" modified="2015-07-22" version="1">MNASSPHAAPDAAAAADRLRELTGAETHDVALVMGSGWVPAAEALGAPEHELRVTELPGFPPPAVEGHSGRIRSYRLGDKRALVFLGRTHFYEGHGVAAVAHGVRTAAAAGCKTVVLTNGCGGLREGMRPGQPVLICDHINLTAASPIEGAHFVDLTDLYSPRLRALCKQVDPSLEEGVYAQLPGPHYETPAEIEMLRRLGADLVGMSTVLEAIAAREAGAEVLGISLVTNLAAGMTGEPLSHEEVLQAGRDSAARMGGLLAEVLRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCY2</accession>
    <name>A0A0F7NCY2_9ACTN</name>
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        <recommendedName>
            <fullName evidence="2">Thiosulfate sulfurtransferase</fullName>
            <ecNumber evidence="2">2.8.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_22925</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>hydrogen cyanide + thiosulfate = 2 H(+) + sulfite + thiocyanate</text>
            <dbReference type="Rhea" id="RHEA:16881"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:18022"/>
            <dbReference type="ChEBI" id="CHEBI:18407"/>
            <dbReference type="ChEBI" id="CHEBI:33542"/>
            <dbReference type="EC" id="2.8.1.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.8.1.1" evidence="2"/>
    <dbReference type="EMBL" id="CP011492">
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    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_22925"/>
    <dbReference type="EnsemblBacteria" id="AKH84582">
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    </dbReference>
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    <dbReference type="PATRIC" id="fig|444103.5.peg.4828"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0016021">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR021309">
        <property type="entry name" value="DUF2892"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
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    </dbReference>
    <dbReference type="InterPro" id="IPR001307">
        <property type="entry name" value="Thiosulphate_STrfase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11127">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="146"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="4">
        <location>
            <begin position="16"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH84582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="193" mass="20000" checksum="B6C47E88976D7A2D" modified="2015-07-22" version="1">MTRIPATVATDQARTRLGELAVVDVRTPAEYASGHLPGAVNIPLDHLRTALDDIRHAAGRRDLLVVCASGARSESACKLLAEQGIEAATLAGGTGAWAAAGHDLHTPAACDTRAGWSMERQVRFTAGSLVLLGLLLGVLVHPALLLISAGIAGGLVFSALTNTCGMAVVLSKLPHNRPRTADLDAARAELRGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCY9</accession>
    <name>A0A0F7NCY9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_22990</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_22990"/>
    <dbReference type="EnsemblBacteria" id="AKH84592">
        <property type="protein sequence ID" value="AKH84592"/>
        <property type="gene ID" value="AA958_22990"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_22990"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4843"/>
    <dbReference type="OrthoDB" id="1181903at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="20"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="236"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="248"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="53"/>
            <end position="60"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH84592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="273" mass="28357" checksum="A97E0407F6C83791" modified="2015-07-22" version="1">MAAPPHTARTESDHDPGVLIDLRGVSRTYDEGPPALDGLTLAVRTGQALAVLGPSGSGKSTLLNLIAGLDRPNAGTVTVDGLRVDGLSESASAKYRRASVGMVFQFFNLLDDLTVADNVLLPAQLAGMPRARAAARAAELLAYLGIERHARAYPGRLSGGERQRVAVARAPMNRPPLLLADEPTGALDTASGAEVRELLRDLHADGQTIVLVTHDLALAESCATRTVELVDGRIARDSADGGTDDGTDDGTGSGTGTPYGTSAAYRDSPRAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7ND18</accession>
    <name>A0A0F7ND18_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Shikimate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_27390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018573.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_27390"/>
    <dbReference type="EnsemblBacteria" id="AKH85339">
        <property type="protein sequence ID" value="AKH85339"/>
        <property type="gene ID" value="AA958_27390"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_27390"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5772"/>
    <dbReference type="OrthoDB" id="1073975at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004764">
        <property type="term" value="F:shikimate 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022893">
        <property type="entry name" value="Shikimate_DH_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21089">
        <property type="entry name" value="PTHR21089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH85339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="315" mass="33017" checksum="323833F2EBE77673" modified="2015-07-22" version="1">MSAPTGAGIGTAADTAAMAFVGVSTGESSIMRIFPEWARLLGLPTARLVGFDLPPDAEPARYRAVAERIRRDPLLLGALITTHKIGVYRAAADLFDELDDFARLCGEVSSVSKRDGRFIGHAKDPLTAGLAIEEFLAPGHFAATGGELLCLGAGGAGTAISYYLARRPDAPARIVCTDRSAGRLAELADVLRRGGADPARLRTVVAEGHADDLLAAAPPGTLVVNATGLGKDRPGSPLSPAARFPRGAVAWELNYRGALPFLHAARAQAAERDLGVVDGWRYFIHGWSQVTAEVFGLTLDAATVDRLSAAAEAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7ND48</accession>
    <name>A0A0F7ND48_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_23425</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017922.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH84667">
        <property type="protein sequence ID" value="AKH84667"/>
        <property type="gene ID" value="AA958_23425"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_23425"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4938"/>
    <dbReference type="OrthoDB" id="665798at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013595">
        <property type="entry name" value="Pept_S33_TAP-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08386">
        <property type="entry name" value="Abhydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519317" evidence="2">
        <location>
            <begin position="29"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="Abhydrolase_4" evidence="3">
        <location>
            <begin position="414"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH84667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="520" mass="54817" checksum="2D5945D8D8CA4EE4" modified="2015-07-22" version="1">MRVTKPTTAVTAATVLLTAMAAGGCAIASSSERDGGLEDGAAAAGIHWGACKNLPKPAPGAPAADTDWECGTLDVPLDHDKPDGEKIGIAMIRAEATGPRENRIGSLLFNFGGPGGSGIETLPGLASQYKTLHKRYDLVSFDPRGVGRSEGVHCLGDRALDKYFAADNTPGDKAEEKAYLDRIHDFAAACEKKSGKVLPHVATESAARDMDLMRAALGDDKMHYFGVSYGTELGAVYAHLFPERIGRAVLDSPVDPTQNSAQRSLAQAKGFQQALESYAEDCARQGKKCPLGEAGSGEPAVATEDVADLLKRLDGKPIPGSSGRDLTESLATGGIAQSLYSKQLWPLLTQGLEQAQDDDGAPLLLLADALNGREPDGHYSTLQSSFLAVNCADTKDRYSIDDIRDRLPEFRKASPVFGDFMAWGLASCDGWPVTGKRSTPQVSAEGADTMLVVGSTGDPATPFEGTQRMAEALGGDVAVKLTRVGEGHGAYGSGNRCTQKAVDTYLLDGRAPQNDTTCRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7ND69</accession>
    <name>A0A0F7ND69_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_33960</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the polysaccharide lyase 8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019632.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_33960"/>
    <dbReference type="EnsemblBacteria" id="AKH86410">
        <property type="protein sequence ID" value="AKH86410"/>
        <property type="gene ID" value="AA958_33960"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_33960"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.7171"/>
    <dbReference type="OrthoDB" id="3136at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901575">
        <property type="term" value="P:organic substance catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008929">
        <property type="entry name" value="Chondroitin_lyas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038970">
        <property type="entry name" value="Lyase_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011071">
        <property type="entry name" value="Lyase_8-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012970">
        <property type="entry name" value="Lyase_8_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004103">
        <property type="entry name" value="Lyase_8_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003159">
        <property type="entry name" value="Lyase_8_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38481">
        <property type="entry name" value="PTHR38481"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02278">
        <property type="entry name" value="Lyase_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02884">
        <property type="entry name" value="Lyase_8_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08124">
        <property type="entry name" value="Lyase_8_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48230">
        <property type="entry name" value="SSF48230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49863">
        <property type="entry name" value="SSF49863"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519323" evidence="2">
        <location>
            <begin position="35"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="3">
        <location>
            <begin position="710"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="3">
        <location>
            <begin position="843"/>
            <end position="974"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH86410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="974" mass="105318" checksum="06745B78D6809B5C" modified="2015-07-22" version="1">MTVSRRVFLGSSSAALAALITAGGPLGRVPPAFAGTTGDLADIRSTLLGIYLAHDWLDDGTTARVEWTYQSQAMEYLSAQRADGSWSDVDYSATNSAANGAAWSPYRALDRMQAMAAAYANPAGPRHRDPALLAGVAKGVEHWFQVKPTNVNWWERGIGIQLRLGRIGLLLHGQLDAARTADIVGVLQSSSSGTGQNAVWYAQNVIFRGLLTPDPALVASGRDAMARAILLNTGDGIQSDLSYHQHGDQLYSAGYGRSMVTDVAQWLYVLRRTSYAFSPASVYDYASWVLDGTRWMINGDHAEFNVFLNPAPRYRSNAERTLEALRRMDDVLPGQAGHFARLRRNIALQSSDTGLRGHKYFWRSDFAAHKRPDWGVTVKMVSARTIGSEWRSSNPRRLNYLYWVPFGTTFIARRGDEYRNLFPVWDWSRLPGCTNPAVVVPLDASNPYRQSTTFVGGVDNGLYGAAALDMEKYGTTARKGYFCFDDEFVALGAGITSTDPNPVVTTLNQARRVGSVVAAGTTVEPGATRTRTGTWAYHDGTGYAFFEPVAMTVRNETVTGSWADIATGQDPAPVTENVFGLWLDHGTEPSGATYAYVVRPGVNQGQAVAYAHHLPVRVLANTTSLQGVRHDGLGISQLLFYSPGTAEIRKGVTLAVDVPCMVILDESGTGAPVITVSAPQAPGVTVAVTLTRFGEVTRGTATLPDGDRQGAGVTLGATANDVALRRPVLTSSEQDTSVGAHFLTDGNPRTRWGSAPSDDEWAMVDLLTPQMADAVALHWDTAFAQAYAVEVSPDGESWRTVHSTTSGTGGTRTLAITPQPVRFVRLNLTKRHTRRGFSLRGLEVHAAVDLARGKPATASSTRVAELAPANATDGQDTTRWGSDYSDPQWLSVDLGSTTAIGTVKLHWETASAKSYRLQVSDDGGDWTDVHSTTSGPGGVETIPVSADARYVRMYGTQRNTQYGYSLFSFEVYGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7ND79</accession>
    <name>A0A0F7ND79_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_34055</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="PATRIC" id="fig|444103.5.peg.7196"/>
    <dbReference type="OrthoDB" id="1529037at2"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:transmembrane transporter activity"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
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        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
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            <end position="61"/>
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            <end position="90"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="249"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH86425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="299" mass="31273" checksum="FAF60A4DA1F1CB1D" modified="2015-07-22" version="1">MNHFIQLVLDGLFVGSFYALVALGYSMVYGIIKLLNFAHGDIYMLGAFAGFTVLSVAAGALGSGIAALVVVMLIAMVATGSLGIVLERVAYRPLRNAPRLSVLITAIGASFALEYGVAVAFGPNPEVYTLEVGNGALNIAGARLSDAQLAMMVIAVALMVALDTLVRKTRSGRAMRAIAQDPKACLLMGIKVDNVISRTFFIGSALAGAAGVMAGAYYGKIDFLMGFIIGLKAFTAAVIGGIGNLRGAMLGAIVLGLLESFGVAFFGSEWRDVFAFGFLILFLTVRPTGLLGERVTERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDE9</accession>
    <name>A0A0F7NDE9_9ACTN</name>
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        <submittedName>
            <fullName evidence="4">Penicillin-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_28060</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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        <property type="gene ID" value="AA958_28060"/>
    </dbReference>
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    <dbReference type="PATRIC" id="fig|444103.5.peg.5915"/>
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        <property type="term" value="F:penicillin binding"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="MecA_N"/>
    </dbReference>
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        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519389" evidence="1">
        <location>
            <begin position="31"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="MecA_N" evidence="3">
        <location>
            <begin position="52"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="2">
        <location>
            <begin position="259"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH85449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="533" mass="54577" checksum="AE7E63881975B8F7" modified="2015-07-22" version="1">MRTGAKAVLCLVLAGMAALAVFGVTSIYQALAGGDDGPGVPTGPPGAAEVRTAARDFLAAWADRRPGAAARLTDDAAEAGPVLGAYFTDALVRKVTLEPGAARGATVPFSVTARIVAEGHAKTWTYDSELTVVRGRTTGKPLVAWDPSVVHPALAGNRRLVTREGETPQVVAVDADGRTLSEEKYPSLGPVFAQLRERYAGKLRGEPGIEVLVEETDGAQRTTPLLGISKGRPAKLPTTLDAGVQQAAEEAVRDHRRASVVAVRPSTGEILAIANTKGGGEFNHALQGATAPGSTFKIITAAALLAAGVTPETPVGCPRTYAHDQGMTFHNVEGGEIEDATFAQDFAESCNTAFVSLSDELADGEPAATARRWFGLGEDDWQTGVATFDGAVPVATGDEKSAALIGQGQVQMNPLTMASVAATVASGGFRQPVLLPRAFHDREVATAAPLPPPVAADLRRMMELTATEGTAAGLGLGAGAGAKTGSAEVDGQERPDSWFTAYRGDVAAAAVVPEGGHGSEAAGPVVSAVLAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDL9</accession>
    <name>A0A0F7NDL9_9ACTN</name>
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        <submittedName>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_28445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_28445"/>
    <dbReference type="EnsemblBacteria" id="AKH85519">
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        <property type="gene ID" value="AA958_28445"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_28445"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5994"/>
    <dbReference type="OrthoDB" id="1432587at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025877">
        <property type="entry name" value="MobA-like_NTP_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12804">
        <property type="entry name" value="NTP_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transf_3" evidence="1">
        <location>
            <begin position="16"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="217" mass="21235" checksum="2C062692C2B304D5" modified="2015-07-22" version="1">MSAPAGSPGTGPAVAGLLLAAGGGRRLGGRPKALLPAGPAGRPLVERAAGVLRAAGCAPVHVVLGAAEEAVRAGAWLAGCVAVSNPDWESGMGSSLRAGLASLEPTTAAAAVVLLVDQPRVGPAAVARVVDAYAAGGAGLAAATYGGVRGHPVLLGRPRWPEVAAGATGDRGARDVLARAARRGELALVECGDVAAPDDVDTPADLALLDEPRAGWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDR4</accession>
    <name>A0A0F7NDR4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_28790</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_28790"/>
    <dbReference type="EnsemblBacteria" id="AKH85579">
        <property type="protein sequence ID" value="AKH85579"/>
        <property type="gene ID" value="AA958_28790"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_28790"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6067"/>
    <dbReference type="OrthoDB" id="1035565at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050580">
        <property type="term" value="F:2,5-didehydrogluconate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19131">
        <property type="entry name" value="AKR_AKR5C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044504">
        <property type="entry name" value="AKR5C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="PTHR43827"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="4">
        <location>
            <begin position="18"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="3">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH85579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="275" mass="29943" checksum="30E57F42AE57EE16" modified="2015-07-22" version="1">MSNVPTITLNNGVAMPQLGFGVWQVPDAEAETAVRTALDAGYRSIDTAAVYGNEAGTGKALTGSGLPREELFVTTKLWNSEHGYDAALRAFDDSLRRLGLDHVDLYLIHWPAPAKDRYLETWRALEKLYADGRARAIGVSNFQPAHLQRVLDEGTVVPALNQVELHPDFAQADVRAFHAAHGIATEAWSPLGQGKGLLDEPVLRELGEKHGRSPAQIALRWHLQLGNVVIPKSVTPSRIRENIDVFGFELDDADMAAVAGLDTGNRIGDNPDDVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDS5</accession>
    <name>A0A0F7NDS5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_33740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019593.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_33740"/>
    <dbReference type="EnsemblBacteria" id="AKH86371">
        <property type="protein sequence ID" value="AKH86371"/>
        <property type="gene ID" value="AA958_33740"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_33740"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.7124"/>
    <dbReference type="OrthoDB" id="1744037at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH86371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="145" mass="15864" checksum="A5FFB5731EF994C3" modified="2015-07-22" version="1">MTDRGPGQVMFHFVRYWSRRPVAADMGGEQGRLVVACEAVHALALRGIPATVNAVAHEIGIDQSGASRLIKSVAAAGYLTMTASAADSRRREASLTPAGRSMLGQAHRWQEEVFAELTTGWSDEKRRDFQQAMTDLMERSQAMDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDU0</accession>
    <name>A0A0F7NDU0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hemerythrin HHE cation-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_29035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018850.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_29035"/>
    <dbReference type="EnsemblBacteria" id="AKH85619">
        <property type="protein sequence ID" value="AKH85619"/>
        <property type="gene ID" value="AA958_29035"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_29035"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6117"/>
    <dbReference type="OrthoDB" id="1622882at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012312">
        <property type="entry name" value="Hemerythrin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01814">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hemerythrin" evidence="1">
        <location>
            <begin position="13"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="166" mass="18178" checksum="BFFC5B67C3760EFB" modified="2015-07-22" version="1">MCEYCGCQAVASVAGLTREHEAVVNLIGAVRDAHRQNDIVRMTEVVREIAAILGPHTQVEERGLFPAMADEFPDHIAVLETEHRQIEAVLAEAEDGVPTAPAWPSRVLNVLALLREHILKEQDGVFPAALASLSIEQWEAVEAVRDRVGSRTPAPWAEADDSSLRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NEA1</accession>
    <name>A0A0F7NEA1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DinB-like protein, PF04978 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_15415</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020096.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86795">
        <property type="protein sequence ID" value="AKH86795"/>
        <property type="gene ID" value="AA958_15415"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_15415"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3244"/>
    <dbReference type="OrthoDB" id="2047691at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007061">
        <property type="entry name" value="DUF664"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04978">
        <property type="entry name" value="DUF664"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH86795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="199" mass="22431" checksum="07372C6FF125D5CF" modified="2015-07-22" version="1">MADTDHKADLHRYLQAAREALLWKLDGLSEYEVRRPLTPTATNLLGLVKHLIGCETAYFADTFGRPFGETVPWLDGPDAEEPNVDMWATADESREDIVHLYERACAHSDATIEALALDDLGRVPHWPDDRAEVSLHRVLVHMLAETQRHAGHADIVRELVDGAAGMRLGNGNMPDGDRAWWESYRRRVEDAAREAQGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NEE2</accession>
    <name>A0A0F7NEE2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha-L-arabinofuranosidase</fullName>
            <ecNumber evidence="3">3.2.1.55</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_29825</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in the degradation of xylan and is a key enzyme in the complete degradation of the plant cell wall. It has a specific arabinofuranose-debranching activity on xylan from gramineae. Acts synergistically with the xylanases and binds specifically to xylan. From small arabinoxylo-oligosides (ranging from arabinoxylotriose to arabinoxylohexaose), it liberates arabinose and, after prolonged incubation, the purified enzyme exhibits some xylanolytic activity as well.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>Hydrolysis of terminal non-reducing alpha-L-arabinofuranoside residues in alpha-L-arabinosides.</text>
            <dbReference type="EC" id="3.2.1.55"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 62 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.55" evidence="3"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_29825"/>
    <dbReference type="EnsemblBacteria" id="AKH85728">
        <property type="protein sequence ID" value="AKH85728"/>
        <property type="gene ID" value="AA958_29825"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_29825"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6296"/>
    <dbReference type="OrthoDB" id="1622507at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046373">
        <property type="term" value="P:L-arabinose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08987">
        <property type="entry name" value="GH62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005193">
        <property type="entry name" value="GH62_arabinosidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40631">
        <property type="entry name" value="PTHR40631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03664">
        <property type="entry name" value="Glyco_hydro_62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="SSF50370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519996" description="Alpha-L-arabinofuranosidase" evidence="4">
        <location>
            <begin position="25"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B-type lectin" evidence="5">
        <location>
            <begin position="26"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU368117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH85728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="460" mass="48698" checksum="22EE0FC27B2EC5AC" modified="2015-07-22" version="1">MVLATAVAVLIALAPTIGAGPAQAASSGALRSAASSRCLDVANASQADGAYLQIWDCSGGSNQQWTHTDSNQLTVYGNKCLDVPGHATTPGTRVQIWSCGGGANQQWRVNSDGTVVGVESGLCLDVSGAATANGTAVVLWTCNGGSNQKWSGLSGTPGDACALPSTYRWSSTGALAQPAHGWASLKDFTSVVHNGKNLVYGTQFSGSSYGSMMFTPFSNWSDMASTGQNGMNQATVAPTLFYFAPKNIWVLAYQWGQWPFIYRTSSDPTNPNGWSAPQPLFTGSISGSGTGPIDQTLIADGQNMYLFFAGDNGKIYRASMPIGNFPGNFGSSYTTIMSDSTNNLFEGVQVYKVKDQNQYLMIVEAIGANGRYFRSFTSSSLNGSWTPQAASESNPFAGKANSGATWTNDISHGDLVRQNPDQTMTIDPCNLQFLYQGKDPAAGGDYNRLPWRPGVLTLQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NEE6</accession>
    <name>A0A0F7NEE6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphoglycerate mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_09465</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019905.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_09465"/>
    <dbReference type="EnsemblBacteria" id="AKH86641">
        <property type="protein sequence ID" value="AKH86641"/>
        <property type="gene ID" value="AA958_09465"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_09465"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1996"/>
    <dbReference type="OrthoDB" id="1122642at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH86641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="211" mass="23220" checksum="F749B52CDE92C00D" modified="2015-07-22" version="1">MRDRRIVLWRHGQTAWNLERRFQGQTDIELTEAGVLQARRAARLLAALRPDAMICSDLLRTRATAAELASLTNLEVTYDSALRETYAGVWQGLTHEEIIARHGEQYAAWKRGEPVRRGGGELETEVADRAAPVVLAHADKLSEAGTLVVVSHGGTIRTTIGRLLGIEPRNWEALGGLSNCSWSVLGESVRGWRLLEHNAGSLPEPVLGDDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NEI3</accession>
    <name>A0A0F7NEI3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CBS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_30170</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_30170"/>
    <dbReference type="EnsemblBacteria" id="AKH85778">
        <property type="protein sequence ID" value="AKH85778"/>
        <property type="gene ID" value="AA958_30170"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_30170"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6371"/>
    <dbReference type="OrthoDB" id="2014094at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007055">
        <property type="entry name" value="BON_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017080">
        <property type="entry name" value="UCP036990_CBS_BON"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04972">
        <property type="entry name" value="BON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036990">
        <property type="entry name" value="UCP036990_CBS_BON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50914">
        <property type="entry name" value="BON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="4">
        <location>
            <begin position="12"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="4">
        <location>
            <begin position="93"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="BON" evidence="3">
        <location>
            <begin position="146"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="212"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH85778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="251" mass="26654" checksum="56AB543E04C4C030" modified="2015-07-22" version="1">MNHSPYLVSDVMTHTVVAVGPEASFKEIAEAMRKWRVSALPVLEGDGRVTGVVSEADLLPKEEYRDSALSVADRDRRPDGIVKAGAVVARDLMTTPAVSVRADATLAEAARAMARRRLKRLPVVDAEGHLTGIVSRGDLLKVFLRPDEDIAEDVQRQVLDPLFPLGGATVHARVDKGVVTLSGWFRNTSLVPLAARMARAVEGVVDVGFRLERPGGAPSGDGQQGRRGAVSPGHEGDGPGDATAPPPAEPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NEL5</accession>
    <name>A0A0F7NEL5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NUDIX hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_19385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020241.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_19385"/>
    <dbReference type="EnsemblBacteria" id="AKH86900">
        <property type="protein sequence ID" value="AKH86900"/>
        <property type="gene ID" value="AA958_19385"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_19385"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4075"/>
    <dbReference type="OrthoDB" id="1672274at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="74"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="242" mass="25989" checksum="E06B764F8DE7D2CE" modified="2015-07-22" version="1">MPTAGIDLLDVEQLVLTEAAEPPLPSHDAEARDRVWEKAIRANPTLFDGPVVACGGLEWLGSRVLRLSWVRVTYRHYALRCIPGATALPSLFVNVAQPSDDGRVLAARMSPATAAPGRWQLPGGSLEPPGEGEVLNESALVGQAARELAEEVGIHMRAEELKLWIVTRGENGSVGLTYLAPTLPEATLRAGLASAAEAERAQGREPELDDIALVASPEEVAGLAGPHADYLEPIIRRFCERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NEQ4</accession>
    <name>A0A0F7NEQ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_14705</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020061.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_14705"/>
    <dbReference type="EnsemblBacteria" id="AKH86771">
        <property type="protein sequence ID" value="AKH86771"/>
        <property type="gene ID" value="AA958_14705"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_14705"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3096"/>
    <dbReference type="OrthoDB" id="2079742at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH86771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="116" mass="12454" checksum="B17D317982245BA6" modified="2015-07-22" version="1">MTEQHITSGPLISMPALTPAALRTAIAQIAPAQLPAFAEHLDRAAEQASAQSTITPLRAFLQYWGEFVAIQRNPERAARLRDLEAEADTAESPDALAPLVAEIQQILGEAQREVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NEY8</accession>
    <name>A0A0F7NEY8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_27095</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_27095"/>
    <dbReference type="EnsemblBacteria" id="AKH85292">
        <property type="protein sequence ID" value="AKH85292"/>
        <property type="gene ID" value="AA958_27095"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_27095"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5708"/>
    <dbReference type="OrthoDB" id="756220at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003445">
        <property type="entry name" value="Cat_transpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02386">
        <property type="entry name" value="TrkH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="81"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="362"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="418"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH85292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="457" mass="47716" checksum="A26D7C9D5914F1A7" modified="2015-07-22" version="1">MRGWLRSTSRSLLATHPARLVVVAFGLVVLIGTLLLSLPVAAEDRSATGFVPSLFTATSAVCVTGLTVVDTGTHWSAFGEGVILALIQVGGFGIMTLASLLALLVVGRLRLRLQLTAQVETKTLGLGDVRRVLLGVAGTTLIVELSVAALLALRFRFGYDQGVGESAYSALFHAVSAFNNAGFGLHVDSLTRYATDPWVTVPVAAAVICGGLGFPVLLEVLRYRHRRRVSGRRGWSLHAKLTLTTTAVLLVAGAALTCALEWSNGATLGPFGTGEKLLSGFFHSAMTRTAGFNAVDIGALHPATLLVTSVLMFIGGGSAGTAGGIKVTTFAVLAVAMVAEVRGEPAAETMGRRIPPAALRQALTVALLAIGLVISATVVLLTMTQERFEAVLFETVSAFGTVGLSTGITADLPAAGQVVLVLLMFVGRVGPITLVSALALRERTRRFQLPEERPVIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NF17</accession>
    <name>A0A0F7NF17_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Coagulation factor 5/8 type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_31065</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019146.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_31065"/>
    <dbReference type="EnsemblBacteria" id="AKH85918">
        <property type="protein sequence ID" value="AKH85918"/>
        <property type="gene ID" value="AA958_31065"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_31065"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6565"/>
    <dbReference type="OrthoDB" id="352760at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002520038" evidence="2">
        <location>
            <begin position="46"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH85918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="601" mass="63963" checksum="09A88FB27B45F747" modified="2015-07-22" version="1">MRVPPTGDSPAPPARSGPSRRTVLAAAAAAAAVPATGAAVSQATAAPRRSAARPLADPDLGPNVIFFDPSSPDIQGRLDQIFRQQESAQFGTGRYALLFKPGTYNGLNAQLGFYTSIIGLGLSPDDTHINGDVTVDAGWFQGNATQNFWRSAENLSLSPVNGTNRFAVSQAAPFRRMHVRGNLNLAPDGYGWASGGYIADSRIDGTVQPYSQQQWYTRDSSIGGWLNAVWNMVFSGVEGAPAQSFPDPPYTTLDTTPISREKPFLYVDGDGYRVFLPALRRNARGTTWGGGSPQGQSLPLSDFHIVKQGATAASINAALREGKHLLLTPGIYHVDAPIAIDRADTVVLGIGYPTIIPDGGVRAMTVADVDGVRLAGFLLDAGPQNSDVLLQVGPDGSAADHANNPTTLQDVFIRIGGAGPGKATTSMVINSRHVVVDHTWVWRADHGDGVGWETNRCDYGVVVNGDDVLATGLFVEHFNKYDVQWNGERGRTIFFQNEKAYDAPNQAAIQNGSLRGYAAYKVADDVGQHEGWGMGSYCYYNVAPSIVQEHGFATPTGSGITFHHIMVVSLGGQGQYAHVINDHGAPTSGTSTIPSKVVSYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NF96</accession>
    <name>A0A0F7NF96_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_27535</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018596.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_27535"/>
    <dbReference type="EnsemblBacteria" id="AKH85362">
        <property type="protein sequence ID" value="AKH85362"/>
        <property type="gene ID" value="AA958_27535"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_27535"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5802"/>
    <dbReference type="OrthoDB" id="1531811at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="76"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH85362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="270" mass="29097" checksum="9501DEFE5AEB9077" modified="2015-07-22" version="1">MAVITTPRKRAARPRTRRSERRGQVRSLALNLIALAAGVALWAVLAVLNVESLPGPLAVAQKAGDLIADGTLADDLLASLRRVFTGFALGTALAIPVGFLMGWYPTARGLLEPYVQFFRTIPPLALIPLAIVLMGIGETPKVFVIFLAAFLSCVVAAFQGVVDVDRTLINAARVLGASDRVIFLKVVIPASTPFILVGMRIGLGAAWATVVAAELIAAQEGLGFRMQHAQTYYDLDTIFVGLITIGVLGLVMDRLLLLAERRLTDWQERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFG6</accession>
    <name>A0A0F7NFG6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4185 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_32030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019311.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_32030"/>
    <dbReference type="EnsemblBacteria" id="AKH86083">
        <property type="protein sequence ID" value="AKH86083"/>
        <property type="gene ID" value="AA958_32030"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_32030"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6763"/>
    <dbReference type="OrthoDB" id="875398at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025442">
        <property type="entry name" value="DUF4185"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13810">
        <property type="entry name" value="DUF4185"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4185" evidence="1">
        <location>
            <begin position="236"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="429" mass="45792" checksum="CEE49E29F0A57D7A" modified="2015-07-22" version="1">MERRQTAGAGIALALLLVVGLVVVLTDDDSGDAAGACTGLAVSGWSADAATTDEFARYGDDAARTDDWTGGDGNHSVRLPDGRTLWLVSDPYLGRVQPPPNKQGQPHAWRDTSLGTPAWTRNAALVMSPDGRLERTLLGGAPGAPASLFPEPGAPVRQWRWPVHAVVEPRAPGSAEQVLRVLLWHRQEAQQPWIYGVPLATEVATLSLPDLRLEGITQVDDQSRVADPADRLVYGAAAVRRGDFTYVWGGTDGRTPEQAERSSRAHLARVPVGRLGDRSAWRYWDGERWSREAASSRPVLGDGGRKGVGSAFSVVRQGDTWVLFTMDAGGPGGSGLTTVASYWACRPEGPWHGPDKAFTAPLPEDAAGGSGAAAYNPQAHPGVGSGDGLLLGYDVNWLDASADDVSANVHRNVALYRPRFVRLHLDTVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFK6</accession>
    <name>A0A0F7NFK6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Potassium transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_27100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_27100"/>
    <dbReference type="EnsemblBacteria" id="AKH87056">
        <property type="protein sequence ID" value="AKH87056"/>
        <property type="gene ID" value="AA958_27100"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_27100"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5709"/>
    <dbReference type="OrthoDB" id="1768241at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006037">
        <property type="entry name" value="RCK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036721">
        <property type="entry name" value="RCK_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02080">
        <property type="entry name" value="TrkA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02254">
        <property type="entry name" value="TrkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116726">
        <property type="entry name" value="SSF116726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="122"/>
        </location>
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        <location>
            <begin position="130"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH87056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="212" mass="22857" checksum="C6296F0035939372" modified="2015-07-22" version="1">MAVIGLGRFGGSLADELTRRGWDVLGIDTDARLVQKYSDALTHAAAADCTDPRTLEQLGVNDFTHVVVGIGTDIQASILVASNLLEAGVTNIWAKAVSRQHGQILERLGVHHVILPEHEMGERVAHLVTGRMLDFIQFDDDFALAKTVAPRLAIGVPLGESRVRTLHGVTVVGIKRPGEEFTYATAETVLEKGDVIIVTGRTQAVETFAELT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NGA4</accession>
    <name>A0A0F7NGA4_9ACTN</name>
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        <submittedName>
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        </submittedName>
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        <name evidence="3" type="ORF">AA958_01160</name>
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        <name type="scientific">Streptomyces sp. CNQ-509</name>
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            <taxon>Streptomycetaceae</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">CNQ-509</strain>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH86474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="287" mass="28061" checksum="2C6DAB79BA27E285" modified="2015-07-22" version="1">MTALFALATSILYGLADFGGGVLSRRSPALTVVVLSQIAATVVLGGVVVATGAWSEAGPLLWFAVAAGVAGPVAMICFYSALARGPMGVVSPLASMAVLVPFGVGLVAYGERPGPVQYAGGAIALAGVVLASGPVRGAPVARRTLLLTLGAAAGFGAVFAFIAEASTTVTGLFLALFVQRAVNVAVGGAALYAAVRRGGAALPEGGWDTIRAAAPGLVFVGLADVAANGTYAIAAQHGPVTLAAVLSSLYPVVTALAARGVLREKLRAVQAAGAGLALAGTVLLASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86534.1"/>
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    <dbReference type="EnsemblBacteria" id="AKH86534">
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    </dbReference>
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    <dbReference type="OrthoDB" id="1654295at2"/>
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        <property type="entry name" value="PafC_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026881">
        <property type="entry name" value="WYL_dom"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="WYL" evidence="1">
        <location>
            <begin position="135"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH86534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="311" mass="33862" checksum="E03AE143BF349500" modified="2015-07-22" version="1">MLSLVTYLRERNGAYLSDVARAFGVTEDELIADLDVLPMCGTSFRGGDLLDIDTDGERIWFHNPESTGTGEPLRLAADEATALLVAARAVATLPGLRAGDRRALLRATAKLEAAAGESAAASSSLSVTFESEGGVFAEVDRAISERRRLWLRYYSPSRDELTEREIDPIRLVSVGHTYVEAWCRLSEARRTFRLDRVAEIRILDAPADPPPVELRDLSEGIVQPSAEDPEVVIEVGPGGRWVAEYYPHDSAEELPHGGLRISLRAPDPASLRRLALRLGRDGRIVAPGDLADSARDAAVKALAAYDVEHQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NGM3</accession>
    <name>A0A0F7NGM3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 19">Adenosylcobinamide-GDP ribazoletransferase</fullName>
            <ecNumber evidence="7 19">2.7.8.26</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18 19">Cobalamin synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17 19">Cobalamin-5'-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
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        <name evidence="20" type="ORF">AA958_06940</name>
    </gene>
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        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16 19">Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 19">
            <text>adenosylcob(III)inamide-GDP + alpha-ribazole 5'-phosphate = adenosylcob(III)alamin 5'-phosphate + GMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23560"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57918"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:60487"/>
            <dbReference type="ChEBI" id="CHEBI:60493"/>
            <dbReference type="EC" id="2.7.8.26"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 19">
            <text>adenosylcob(III)inamide-GDP + alpha-ribazole = adenosylcob(III)alamin + GMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16049"/>
            <dbReference type="ChEBI" id="CHEBI:10329"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:60487"/>
            <dbReference type="EC" id="2.7.8.26"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 19">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 19">Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 7/7.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="19">Cell membrane</location>
            <topology evidence="19">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 19">Belongs to the CobS family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.26" evidence="7 19"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_06940"/>
    <dbReference type="EnsemblBacteria" id="AKH86589">
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        <property type="gene ID" value="AA958_06940"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_06940"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1450"/>
    <dbReference type="UniPathway" id="UPA00148">
        <property type="reaction ID" value="UER00238"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051073">
        <property type="term" value="F:adenosylcobinamide-GDP ribazoletransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008818">
        <property type="term" value="F:cobalamin 5'-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00719">
        <property type="entry name" value="CobS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003805">
        <property type="entry name" value="CobS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34148">
        <property type="entry name" value="PTHR34148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02654">
        <property type="entry name" value="CobS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 19" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 19" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="13 19" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="12 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="165"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00010561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00015850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00025228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00032605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00032853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="AKH86589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="255" mass="24448" checksum="41F9CAC339FEE5AD" modified="2015-07-22" version="1">MRFACGTLTALPVRVHRWDRAAARGGMAAAPLVGLLLGALAAGAGRLLLLAGAGAALAAVVTVAVPAVLTRGLHLDGLADTADGLGSGRPAAGALAVMRRSDIGPFGVITLLLVLLGQVAAVAELYGDDSGIRAAVAVTAAAVAARAALTLAARTGVPPARPEGLGAAVAGVLSTRTAVACTAVAAAVLAAAAGLLSGPYAALHTALAVAAGLAAAELLRHHCVRRLGGVTGDVFGALAETAATAALIAAVLGPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NHA5</accession>
    <name>A0A0F7NHA5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cation transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_32140</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019330.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_32140"/>
    <dbReference type="EnsemblBacteria" id="AKH86102">
        <property type="protein sequence ID" value="AKH86102"/>
        <property type="gene ID" value="AA958_32140"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_32140"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6786"/>
    <dbReference type="OrthoDB" id="948593at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="SSF160240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="SSF161111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="26"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH86102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="309" mass="32624" checksum="B571CBC0C685E664" modified="2015-07-22" version="1">MGAGHDHSHGSSGGTASAAHRGRLRIALLLTLSVLGLQVAGGVITGSLALVADAGHMATDVVGLSMALLAIHFANRPTSERRTFGFARAEILAALANCLLLFGVGGYILYQAVMRFMDPPEIEGGLTFAFGAAGLVVNLISLALLMRGRRESLNVRGAFLEVLADALGSVAVIISALVIVTTGWQYADPVASLAIGSMIIPRTFRLLREALDVLLEAAPKDVDVSEVRTHILALPGVVELHDLHVWTITSGMPVISAHVVVKESVLQAVGQERLLHDLQGCLGDHFDVAHCTFQIEPVGHAEHEANLCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NHC2</accession>
    <name>A0A0F7NHC2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transketolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_32310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019359.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_32310"/>
    <dbReference type="EnsemblBacteria" id="AKH86132">
        <property type="protein sequence ID" value="AKH86132"/>
        <property type="gene ID" value="AA958_32310"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_32310"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6821"/>
    <dbReference type="OrthoDB" id="900125at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transket_pyr" evidence="1">
        <location>
            <begin position="2"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="307" mass="32254" checksum="B9AA75058765425D" modified="2015-07-22" version="1">MDTMRERFASVTSRLLDEDPRLAVVLAEIGTDGFAEAARRHPDRVINVGIREQLLVGVGGGLALAGMRPVLHTFASFLVERPFEQVKLDLGHQDAGAVLVSAYGSYDWPAGGYTHMAPGDIALLDTLDGWTVHVPGHPDEAATLLRHAVAAGDDKVYVRLSQQANAAGRPVDGAGFLTVREGRAGVVVAVGPLLDDVLAATEGLDVTVLYATTVRPFDTAALRAAVGPGPADVVLVEPYLAGTSTAYANDALADVPHRVLGLGTARGELRRYGTVPEHLRAHGLDPASLRERIAAFTGPRDGARAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NHT1</accession>
    <name>A0A0F7NHT1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Biotin carboxylase</fullName>
            <ecNumber evidence="2">6.3.4.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">AA958_24300</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CNQ-509</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="6.3.4.14" evidence="2"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_24300"/>
    <dbReference type="EnsemblBacteria" id="AKH87009">
        <property type="protein sequence ID" value="AKH87009"/>
        <property type="gene ID" value="AA958_24300"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_24300"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5121"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004075">
        <property type="term" value="F:biotin carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013537">
        <property type="entry name" value="AcCoA_COase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CbamoylP_synth_lsu-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08326">
        <property type="entry name" value="ACC_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="13">
        <location>
            <begin position="1"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="12">
        <location>
            <begin position="111"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="11">
        <location>
            <begin position="563"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="14">
        <location>
            <begin position="1531"/>
            <end position="1814"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AKH87009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="1818" mass="195110" checksum="B01360A36253FA01" modified="2015-07-22" version="1">MRLIKAVGELNATGAPRIETVAFYTDADATAAFVRAADLGYDLGRAADRPYLDLAVLERALVESGADAAWVGWGFVAEDPAFAELCGKLGVTFIGPGPEAMRKLGDKISAKLLAEEVGVPVAPWSRGPVADLDTALRQAERIGYPLMLKATAGGGGRGVRAVHAPDELADAFQRTSEEAERSFGNGALFLERLLVHARHVEVQVIADGQGGVWALGVRDCSVQRRNQKIVEESASPVLAAEQVARLKESAERLALAVGYRGAATVEFLYQPKDGMFAFLEVNTRLQVEHPVTEATTGMDLVKAQLHVAAGGRLTGERPAELGHAVEARLNAEDPDRDFAPAPGRIALLDLPAGPGIRVDTGVSQGDTIPADFDSMIAKVIAYGRDRAEALSRLRHAMRETTVLIEGGTTNKSFILDLLDEPAVIDAGADTGWIDRVRAGGGLASPRHSGVALAVAAIEAYEDGKQAELQRLLGTARGGRPQVHHEGGRPVDLTLRGAGYRLTVAETGPGRYRVGFRSGTDTDDGTVRAVDAVLERFDQHTGQIRLNGHRFRLVTGAHGPVHLVEVDGVTHRISRDEGGVVRSPAPALVVATPLGAGDEVDEGAPVLVLESMKMETVLRAPFRAVLKESLVAVGSQVETGAPLLRLEPLDDVDAAPVAAGADLDLPAEAAGQSAEQRAARGLADLRSRLLGFDVDPAGADDALAGYLAVRAVLPERPLAAEAGLLEVFADLSELSRNKPEHEETAAETWVRSPREFFHTYLQSLDAERAGLSETFQGRLTRVLGHYGVESLDRTPALEEAVFRIFLARQAATADVAVITALLQQWLTEAPPPDGLRQVVSQALERLIRATQLRFPLVGGLARSLVFRWYAQPLLRHTRATVYNRIRDHLHHLDAHPDAPDRDRRIADMVASPESLIQLLGERIARPDTEADPLLEVLVRRAYRDHRLTGVRCETVAGRPFVTGRYELDGVSHRLLVTVADFGDLAGAAATVAEVAAAEPDSTAVVAEFYLTWTGRPPETDDMAAGLRAALSGSLPASLHRITTTVAGHNGAAPQHFTFLPSPEGPEEDKLMRGMHPLIGQRLLLRRLRNFDLTRLPSVNEDVYLLRCVAPSNPADERLVAMAQVRDLTPLRDEEGRILALPEVEAALGACLDAIRREQVRRPGSRRQDTNRIFINVRPPSDLTLAELNDVARRVLPTTRGLGVEEVLLLGCRRDRRGGLVPAAVRVSYDVAAGVRLSVTAPPTDLLQPLDDYGQKVLRVRRRGTVYPYELFDMIAGAGGTFTEHDLDDSGALAPVQRPKGLNKAGLVAGVATTPTERYPEGVTRVVLLGDPVKALGALSEAECARVVAALDLAERLRVPVEWYALSAGARIAMDSGTENMDWIARALRRIVHFTQDGGEINVVVAGVNVGAQPYWNAEATMLMHTRGVLVMTPDSAMVLTGKRSLDFSGGVSAEDNFGIGGYDRVMGPNGQAQYWAPDLKAARDVLLSYYDHSYVLPGEAGPRKARTSDPVDRDVCDFPHAAEGSDFTTVGEIFSAATNPDRKKPFDIRTVMRAVTDQDHAVLERWADMAEAETAVVQDVHLGGRPVCLVGIESRSVPRRGFPPTDGPDAYTAGTLFPRSSKKVARAVNAASGNRPLVVLANLSGFDGSPESMRELQLEYGAEIGRAIVNFRGPIVFCVISRYHGGAFVVFSKALNPGMTVLAVDGSYASVLGGAPAAAVVFAAEVDARTAADARVTGLESRLSAASGRERAQLAGRLESVWAAVRAEKLGEVAAEFDGVHSIRRAREVGSVDAIIRPEELRPQLIAAVERGLAEGTPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NHU4</accession>
    <name>A0A0F7NHU4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_17390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86843">
        <property type="protein sequence ID" value="AKH86843"/>
        <property type="gene ID" value="AA958_17390"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_17390"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3657"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012551">
        <property type="entry name" value="DUF1707"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08044">
        <property type="entry name" value="DUF1707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH86843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="192" mass="21014" checksum="C8078DE0484489D1" modified="2015-07-22" version="1">MRASHADRDRVVDVLRIAAGEGLLTADELDQRVEAALSARTRSELAVLTADLPPVPAGAGAAGSEVKDLVRIEQIHGGAIERVGRWVVPRRLELAVTHCEVTLDFTDAVITQDTLRIDVAMMGKNLTLVTGPGIVVDTDGLRLVHSKVVFREPPADSGVPVRLRVELYGQKAHGRVVVRPRRRTFGQWLLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NIM8</accession>
    <name>A0A0F7NIM8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_29965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_29965"/>
    <dbReference type="EnsemblBacteria" id="AKH87133">
        <property type="protein sequence ID" value="AKH87133"/>
        <property type="gene ID" value="AA958_29965"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_29965"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6327"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003719">
        <property type="entry name" value="Phenazine_PhzF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13774">
        <property type="entry name" value="PTHR13774"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02567">
        <property type="entry name" value="PhzC-PhzF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016184">
        <property type="entry name" value="PhzC_PhzF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00654">
        <property type="entry name" value="PhzF_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="1">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR016184-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH87133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="302" mass="31448" checksum="93E6880CB7628D15" modified="2015-07-22" version="1">MQATARGAGAVRIRDSSHRYVVVDAFATQPLSGTPVAVFFDAADLTDERMRRIAKAMNLSEVVFLLPPGATDADVRARVFTPDAELPFAGRPLLAAAVAVALDLRTDRLRFETRTGVVPFVVDRTPAAQSGGGVAYVSMEQPIPVWEPYEHAGALLDALGIAASTLPVDLYRDGPRHVFAGLPDAAALAGLRPDRRALAAFPGTAATCFAPEGERWHARVFSPAHGGAEDASAGSAAGALAVHLARYGLVAYGKTVEIHQGGHLGGRSSVMFAEATVAGGGELDRVRVSGHGTVAAEGTIHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NIT4</accession>
    <name>A0A0F7NIT4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_12510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019992.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_12510"/>
    <dbReference type="EnsemblBacteria" id="AKH86717">
        <property type="protein sequence ID" value="AKH86717"/>
        <property type="gene ID" value="AA958_12510"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_12510"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2628"/>
    <dbReference type="OrthoDB" id="1621669at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="505" mass="49809" checksum="E3EE4E05C96C0027" modified="2015-07-22" version="1">MIAAGALVAGLLPAAGSAAEEGAVSVSAGYVCEGAGGTAVDLPVDFTGSFPASVRSGEAIRPGDLTMSATLGGGLLDGLPAGEGATVGGSASVAMGVAQGPESADYPWAGATGEPVQVPADGTATVSFSGAMPSATAGGAGDVVFTLGPLTLELQGTPPEPGDDSSPPADPADPAADPADQDDPADPAGPGATTLTCTLADGQDATLATVAVPDESGTPGGGDTGADDGGAGQGTPGATGGRSGSAGADAEAAPGDEPAETGDVTPCPPGQPPTAELDPDRLIEPPAGTTTLTLPGVYTCTAAVGIVNSRKLNGALIANDPHAPTLDSVRVLLNKQMIISPGNFYNGTRNVAEFTLPDSEATFLTFGFMPVTGKVEFTNEPMTIVTEQGSSIDTNETTAGFYQALRVYDVKVNGVPLDVGDDCRTSAPLDVVLKGKYPEYRVFTGGTLRSLVTVPPFTGCGTGGEDLDPLFTSTLSGPGNYVELKQSPLCTMPCTPAVPGLPADG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MXM2</accession>
    <name>A0A0F7MXM2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Arabinose transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_01090</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH80995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014361.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH80995">
        <property type="protein sequence ID" value="AKH80995"/>
        <property type="gene ID" value="AA958_01090"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_01090"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.240"/>
    <dbReference type="OrthoDB" id="1452500at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AKH80995.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
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    </evidence>
    <sequence length="400" mass="40539" checksum="C94D0C66FE3532B2" modified="2015-07-22" version="1">MPRTVWVLIAARAVNRLGAFSLPFLAVLITARYDAAPATAGLVVGVFGLATIPSRLAGGRLADRFGRRPTMVAGLGGCAVAQAGIAVAPSLAAVVGFTLLLGLVFELYEPPSQAMIADTVGEAARVRAYSLLNAALAVAGLAAGGIAAGLGRWDLRWLFVADAVTCLLCALVVRIALPADRPRARGQGDGAANVAPWRDRILLAMLFTGTLFAVVYLQIAVTLPLALAERGLEPADAGLLLAVSALTVVAGQPLLRLEWLSARSAPPAFAIGGLLLAAGLTGYAVADSLSAHVIATVVWSLGDLLLVGRALAVVADLAPPRGTGRYLAVYGTGWGIAGVAAPLLGTQLLERAGVAAMWSVMAGLCVVLAVVQPAVALAAGRRVAGGGPPVPAAPSERTLS</sequence>
</entry>
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                <person name="Albersmeier A."/>
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                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <dbReference type="PROSITE" id="PS50943"/>
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        <source>
            <dbReference type="EMBL" id="AKH81005.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
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    </evidence>
    <sequence length="190" mass="20263" checksum="468C4542E737721D" modified="2015-07-22" version="1">MADFDVLTHALARNLKHWRNERGFTLDSLAGRSGVSRGMIIQIEQARTNPSVGTTVKLADALGISITTLLDYEHGPEVQLVPPHRAVRMWTTKAGSASRLLVGTQSPGPFEMWSWRLMPGDGSGSDPHPAGTTELLHVTAGELTLVVAGTAHLVPAGTSASFEASAPHAYRNEGRDPVELVMAVSVPPAR</sequence>
</entry>
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                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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            <end position="328"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <sequence length="330" mass="34640" checksum="CC1E0EF362B72F46" modified="2015-07-22" version="1">MRMLINVPETVVPDALRGMSAAHPDLTVDVENRVVVRRDAPVTDKVGLVSGGGSGHEPLHAGFVGPGMLDAACAGEIFTSPVPDQMTRAAAAVDAGRGVLFIVKNYTGDVLNFDMAADLVQDEGIQVAKVLVDDDVAVTDSLYTAGRRGVGATLFVEKIAGAAADEGAPLERVEALARKVAESSRSFGIALSAVTTPAKGSPTFDLPDGELELGIGIHGEPGRERRPMMTSREIADVTVDAVLEDLRPSGPVLALVNGMGATPLIELYGFNAEVQRALTERGVSSARTLVGNYVTSLDMAGVSLTLCQADEELLRLWDAPVRTPGLRWGM</sequence>
</entry>
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        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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        </location>
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        </location>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="430" mass="45982" checksum="61D522390B9FA853" modified="2015-07-22" version="1">MSTSVRARRRPRVRVALAAAVAAVLALPSCGFVRSGDEAGKSTTLSSYTSPEQNTGLKELYAAYEKQEGVTFDASHAAAEELNQQLRVQLTSGTAADVIRVSPGYSSPVSAGVLGQTDELADLSDSAWADRLDDSTAVLAQAGDRTVAYPVGRNAIVAAYNKEVFAELDLEVPTTWSELLDACEALKKAGKTPIAAGLVEGIYLQFYVYALAGTLVHAEQPDLDERMRAGKTSFAKEPAWTEVFDKLTKLSEYFTPHALGTPPDQAQQELARGKAGITLLVSAGLPQLYDYAPDGAETFGLFALPADEDPGATMLPTAPDFLAVNAASPRVAQAKKFLDFLSRPKNVDRYAKTLGVLPGLGKTPDAKDSPLAEVLPLVEEGRTAPYANYLWSNGDTQQTLLQSGQQLLDGKIDVPELLRKMDKQYAKGAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MYQ4</accession>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_00280"/>
    <dbReference type="EnsemblBacteria" id="AKH80861">
        <property type="protein sequence ID" value="AKH80861"/>
        <property type="gene ID" value="AA958_00280"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_00280"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.66"/>
    <dbReference type="OrthoDB" id="744602at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="5">
        <location>
            <begin position="16"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="238"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH80861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="467" mass="48931" checksum="9E5F000626A04378" modified="2015-07-22" version="1">MPTSEAARFPGRLAIRFPVVDPATGEAFDEAPDQQPDELDAVVDRAHRAWPGWRADPAARTAALRMAAGAVEAAGDDLARLLTREQGKPLAESYAEVARTAARLRYFADLAPRTRRIVDGRPVSSEVRWRSLGPVAAIVPSNFPLQLAAAKFAPALAAGNTVVLKPSPFTPLATRLLDSVLATALPEDVLTVVTGREPLGARLASHPGIRHVTFTGSVSTGRTVAEAAAASLSRVTLELGGNDAAVLLDDVDVDRIVDRLFWAAFRNCGQVCMAVKRVYAPAGLHAEVVEALAQCAKTVTVGAGLDPDARLGPVNNAPQLARIEQVTQQALADGARAAAGGHRLDGPGYFFAPTILTDVPPGAPVVTGEQFGPVLPVLPYRSLDEAVDAANGTGFGLGGSVWGTDLDRAEAVAERLECGTAWVNHHAELSLAQPFAGVKDSGVGVAGGPWGLYGNLRPFVVHRPQEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MZ74</accession>
    <name>A0A0F7MZ74_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_01300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014391.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH81026">
        <property type="protein sequence ID" value="AKH81026"/>
        <property type="gene ID" value="AA958_01300"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_01300"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.287"/>
    <dbReference type="OrthoDB" id="796397at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008557">
        <property type="entry name" value="PhoX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05787">
        <property type="entry name" value="DUF839"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519591" evidence="1">
        <location>
            <begin position="38"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="452" mass="48031" checksum="599D6A34F7F7741D" modified="2015-07-22" version="1">MTGTPAERPTGSGFERRTLLRGAAVAAGASVPFQALAARTAAAAPVKFEFDAGYGPLSPVKDQATGLELLELPRGFEYISFGWTNDVMDDGVRTPSAHDGMAAFRYGDKVHLVRNHERGAGPAFTAPAYNPEAGGGTTTLVFDPDAGQWLESYGSLGGTIRNCAGGPTPWKTWLSCEETFSTTAGKRHGYIFEVASEGKGNPEPYKAMGRFNHEAIAVDPATGYVYETEDRGDASLYRFVPAVRGDLSKGGRLEALRIGSTSYDTRLDGEREYGTVSWVPVEDVDPAADTVRLQAQANGAAVFSRLEGAWYGNDRIYVITTDGGPARQGQVFELDPATDGLRVLFASPGAEVLNAPDNMCVSPRGGLVLCEDGGGTEYVHGLTTGGEIFRFAANNVDLRGGTAGKNVAADDHRGSEWAGSVFEPKNGNWLFVNIQTPGITFAISGPWRQGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MZF1</accession>
    <name>A0A0F7MZF1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_01690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_01690"/>
    <dbReference type="EnsemblBacteria" id="AKH81091">
        <property type="protein sequence ID" value="AKH81091"/>
        <property type="gene ID" value="AA958_01690"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_01690"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.370"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519602" evidence="1">
        <location>
            <begin position="26"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="81" mass="8106" checksum="463A73E8B69235D9" modified="2015-07-22" version="1">MPGRLARCAAATAALLPLLAAGSPAAGSARSGAGGLQESFAAAARQYGVPESVLLGVAYLESRWDAHGGAPRWRAATGRCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N048</accession>
    <name>A0A0F7N048_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metallophosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_06750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_06750"/>
    <dbReference type="EnsemblBacteria" id="AKH81960">
        <property type="protein sequence ID" value="AKH81960"/>
        <property type="gene ID" value="AA958_06750"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_06750"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1410"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="1">
        <location>
            <begin position="2"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="249" mass="27577" checksum="39D8B11C8A03E764" modified="2015-07-22" version="1">MVSDVHGNSADLARAGDGADALVCLGDLILFIDYADHSRGIFPDLFGVANTTRSVELRTARRFDEHREFVGSLWAGMDKRGEIEKAVRQQYAELFAAFPTPTYATFGNVDIPRLWPEFAREGTTVLDGERVEIGGLVFGFVGGGLQTPMRTPYEIDDETYAAKVAAVGDVDVLCSHIPPLVPDLCYDTVARRFERGSEALLEAVHKVRPRYALFGHVHQPLARRMRIGATECVNVGHFASRGKPWVLEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N082</accession>
    <name>A0A0F7N082_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_07075</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015370.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_07075"/>
    <dbReference type="EnsemblBacteria" id="AKH82020">
        <property type="protein sequence ID" value="AKH82020"/>
        <property type="gene ID" value="AA958_07075"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_07075"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1483"/>
    <dbReference type="OrthoDB" id="1247435at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01823">
        <property type="entry name" value="SEST_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037460">
        <property type="entry name" value="SEST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37981">
        <property type="entry name" value="PTHR37981"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002518924" evidence="1">
        <location>
            <begin position="32"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH_hydro" evidence="2">
        <location>
            <begin position="46"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH82020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="299" mass="30827" checksum="AFAAC604C54A290E" modified="2015-07-22" version="1">MNVLPKLLKGALGAAAATGLVVAGTAAPAAADSAVTDAAAGEVYVALGDSMASGPLIPLPTGPLACGRSTENYAHELADRLDVAELRDVTCSGAKTDHMTQPQSLSLLDVDMGEAPPQFDALSADTTLVTLTIGGNDAGLVGVAQDCMQLNPLGDPCKDGFMEGGVDTVAQRIEAMGPKLGAVLDGIHARAPQARVLVTGYGDYIKPGGCWPYQPVLAPDADWLQGSVNHMNRVIADRAAAHGAEYVDVFTPSRGHDSCQSPEKKWVEGYVPTAPAAPLHPNARGEEAYAGIIHDRLTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0F8</accession>
    <name>A0A0F7N0F8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NIPSNAP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_07605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015470.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH82120">
        <property type="protein sequence ID" value="AKH82120"/>
        <property type="gene ID" value="AA958_07605"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_07605"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1596"/>
    <dbReference type="OrthoDB" id="1983009at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012577">
        <property type="entry name" value="NIPSNAP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07978">
        <property type="entry name" value="NIPSNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NIPSNAP" evidence="1">
        <location>
            <begin position="3"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="105" mass="11720" checksum="C5C1AE3E4B0D713B" modified="2015-07-22" version="1">MDQIRIYTLRTTEALEKYATVHWPRHIASMPEFGVTVRGFWIDHEADAHRLIALLSFRKGIDPAEFTTAYVASPEFAADMQGFDLDDITGAEELLLDPVAGSPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0R0</accession>
    <name>A0A0F7N0R0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_00755</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH80939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_00755"/>
    <dbReference type="EnsemblBacteria" id="AKH80939">
        <property type="protein sequence ID" value="AKH80939"/>
        <property type="gene ID" value="AA958_00755"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_00755"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.171"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH80939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="88" mass="8962" checksum="938770CCF6BA33C9" modified="2015-07-22" version="1">MVAAQSSGEDSAACSRFGQHVLAATDWRAPSGDWYLLAAGSRDVRDLEATGDVTATAEGPTLAERAANGVRARVTGRVEGGGSLATGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0X6</accession>
    <name>A0A0F7N0X6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CTP synthase</fullName>
            <ecNumber evidence="9">6.3.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Cytidine 5'-triphosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Cytidine triphosphate synthetase</fullName>
            <shortName evidence="9">CTP synthetase</shortName>
            <shortName evidence="9">CTPS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">UTP--ammonia ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">pyrG</name>
        <name evidence="13" type="ORF">AA958_04955</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + H2O + L-glutamine + UTP = ADP + CTP + 2 H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:26426"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + NH4(+) + UTP = ADP + CTP + 2 H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:16597"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>H2O + L-glutamine = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="9">Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; CTP from UDP: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="9">CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the CTP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.2" evidence="9"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015006.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_04955"/>
    <dbReference type="EnsemblBacteria" id="AKH81651">
        <property type="protein sequence ID" value="AKH81651"/>
        <property type="gene ID" value="AA958_04955"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_04955"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1042"/>
    <dbReference type="OrthoDB" id="783657at2"/>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00277"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003883">
        <property type="term" value="F:CTP synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044210">
        <property type="term" value="P:'de novo' CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03113">
        <property type="entry name" value="CTPS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01746">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01227">
        <property type="entry name" value="PyrG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004468">
        <property type="entry name" value="CTP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017456">
        <property type="entry name" value="CTP_synthase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033828">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550">
        <property type="entry name" value="PTHR11550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06418">
        <property type="entry name" value="CTP_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00337">
        <property type="entry name" value="PyrG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 9" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTP_synth_N" evidence="12">
        <location>
            <begin position="7"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="GATase" evidence="11">
        <location>
            <begin position="305"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Amidoligase domain" evidence="9">
        <location>
            <begin position="1"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="L-glutamine binding" evidence="9">
        <location>
            <begin position="386"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="544"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; for glutamine hydrolysis" evidence="9">
        <location>
            <position position="385"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="519"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="521"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="17"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="18"/>
            <end position="23"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="151"/>
            <end position="153"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <note>allosteric inhibitor</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="191"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="227"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="358"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="409"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="471"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF06418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AKH81651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="583" mass="63218" checksum="01AD52CA18801C10" modified="2015-07-22" version="1">MPSTTSKHIFVTGGVASSLGKGLTASSLGALLKARGLRVTMQKLDPYLNVDPGTMNPFQHGEVFVTNDGAETDLDIGHYERFLDVDLDGSANVTTGQVYSSVIAKERRGEYLGDTVQVIPHITNEIKSRIRRMSSDDVDVVITEVGGTVGDIESLPFLEAVRQVRHEVGRDNVFVVHISLLPYIGPSGELKTKPTQHSVAALRSIGIQPDAIVLRADREVPAAIKRKISLMCDVDEAAVVAAIDAKSIYDIPKVLHAEGLDAYVVRKLDLPFRDVDWTEWDDLLRRVHEPAHEVTIALVGKYIDLPDAYLSVTEAIRAGGFANNARAKIKWVTSDDCRTPQGAREHLADVDGIVIPGGFGERGVEGKIGAITYARENRVPLLGICLGLHCIVIEAARNLAGISGANSTEFDQAATDPVISTMEEQLDIVAGEGDMGGTMRLGLYPAKLAEGSVVREAYADQPYVEERHRHRYEVNNSYRSELEKKAGLSFSGTSPDNKLVEYVEYPREVHPYLVSTQAHPELRSRPTRPHPLFAGLLKAAVARHEAARETGAQQQGGVQQQAGPHGAHAGAQKPVAAVREGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0Y6</accession>
    <name>A0A0F7N0Y6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">LacI family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_08590</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015628.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH82280">
        <property type="protein sequence ID" value="AKH82280"/>
        <property type="gene ID" value="AA958_08590"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_08590"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1812"/>
    <dbReference type="OrthoDB" id="1796334at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00036">
        <property type="entry name" value="HTHLACI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="5"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="HTH cro/C1-type" evidence="5">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH82280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="343" mass="36327" checksum="9C133E5566E8D1B3" modified="2015-07-22" version="1">MGRPPTLEDVARVAGVSRATVSRVINGTRNVDPAIQETVRAAVRTTGYAPNSAARSLVTRRTGAVGLVISGAGEGGDEAAYRRYVFSDPFFGRVVDGVMGALRPRGMHPMLMLAETTEAREQVVAHLRQGIADGALLVSTHGEDPLPGMLTAAGVATVLFARPARPVPAGYVDLAHRDGARLAAEHLLARGCRRPVTICGPLDVLAGQERLDGFNQAMARHGHAYVPCAEGNFTAASGEQSMTRLLREHPDLDGVFAANDLMARAAVQVLREQGRRVPEDVAVIGFDDSSAATSTRPELTTVRQPVEEMAGEMVSLLLTALDSPGASPRSVIFEPDLVVRESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N188</accession>
    <name>A0A0F7N188_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sugar kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_05725</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015134.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_05725"/>
    <dbReference type="EnsemblBacteria" id="AKH81781">
        <property type="protein sequence ID" value="AKH81781"/>
        <property type="gene ID" value="AA958_05725"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_05725"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1198"/>
    <dbReference type="OrthoDB" id="1604782at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="3">
        <location>
            <begin position="2"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH81781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="314" mass="31668" checksum="D972F1364F86F4DC" modified="2015-07-22" version="1">MIVVGGEALIDLVPAGGGGVLPALQPVRGGGPYNTAVALGRLGADVAFASRVSTDAFGAALMAGLDAAGVATGLVQRGPEPTTLAVADVSPDGSAGFRFYAEGTADRLFRAPDALPPETRALAVGTCSLVLEPGATAYETLLKRAAADGLFTLLDPNVRAGLIEDADAYRARFLAWLPHVALLKLSVEDAQWLAGGRPWAEALPGWLAAGPRAAVLTRGGEGLTAVVAQGLERYDVAAPPVEVVDTIGAGDTVNAALLHWFAAHDALTPGALAGLGPDGWRAALGHAARAAAITCSRAGAEPPYAAELDGFADG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N1D5</accession>
    <name>A0A0F7N1D5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glycosyl hydrolase family 109 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_02320</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014563.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_02320"/>
    <dbReference type="EnsemblBacteria" id="AKH81199">
        <property type="protein sequence ID" value="AKH81199"/>
        <property type="gene ID" value="AA958_02320"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_02320"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.497"/>
    <dbReference type="OrthoDB" id="1465613at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519025" description="Glycosyl hydrolase family 109 protein" evidence="3">
        <location>
            <begin position="46"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA" evidence="4">
        <location>
            <begin position="78"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="443"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="460"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00016631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH81199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="478" mass="52928" checksum="60D4333573AB3EE6" modified="2015-07-22" version="1">MREENATPRPGDSDDGYSRRSVLRSAGIAGAGLGLGAFGASQAQAADAGAAGEAAAPAVPPRRGRTMIGVPFETHTTVRVGIVGLGNRGGGMIDLFLAQPGVRVTALCDPVVDKVERAAKKVVAAGQPAPATYTKGDHDFEQLCARGDIDFVYVATPWDWHFEMAKAAMTNGKHVGVECPIAMTVKELWDLVDLSERTRRHCMQLENCAYGKNEMRVLRMAHAGLFGELLHAAGAYNHDLRGLMFDPDYYEGPWRRLWHTRLRGDLYPNHGFGPTANYMDVNRGDRVTQISSFGTPALGLAEYREEHMPAGDPSWKETYIGSDRTFSVLQTARGRVIRLEHDVSTPHPYSRINSLGGTKGVFEDYEPRIYLEPMHTDDRWHSFADFAEYDHWLWKEHSNPPGGHGGMDYIMIFRLMQCMRLGLVPDFDVYDAVTWTAPVPLSHESIKAGGRPQQIPDFTRGGWKDKRSGVDSEKPDEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N1M1</accession>
    <name>A0A0F7N1M1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sugar ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_02770</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014637.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_02770"/>
    <dbReference type="EnsemblBacteria" id="AKH81274">
        <property type="protein sequence ID" value="AKH81274"/>
        <property type="gene ID" value="AA958_02770"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_02770"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.593"/>
    <dbReference type="OrthoDB" id="447734at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519035" evidence="2">
        <location>
            <begin position="22"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH81274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="438" mass="46799" checksum="F0D3F9DF80FC3326" modified="2015-07-22" version="1">MRRIRLAATAALATALSVTAAACGGGSSTGSEGSNDKPDELTYWASNQGTSLEHDKEVLTPEIEKFEKKTGIDVKLEVIPWDSLLDRILAATSSGQGPDVLNIGNTWSASLQASEGLLAWDDKTLDRIGGRDRFVPSALAAAGAEGQDPAAVPLYSLSYALYYNKQMFADAGIEEPPATWDDFVAVGKKLTKDGKYGVAVEGGNPVENSHHAFVFGKQHGADFFDAEGNPTFDTPEAVAAVKQYVDFLADDKIAAVGNAEYAQNQSIKDLATGKAGMLLWQAAGSSLKAHGMKPEEYGVAPVPMQSENPPEGRNVNSMVAGINIAVFKNTDNLDGALDFVEFMTSTEEQQILNKTYGSIPPVKEAQEHEAFSTTDLTVLREVLSTSSAPLPQVPDEAQFETLVGDAMKELFADAAAGDEVTTESVRKRLTEAQQQMQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N1P1</accession>
    <name>A0A0F7N1P1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AA958_09935</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015842.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_09935"/>
    <dbReference type="EnsemblBacteria" id="AKH82500">
        <property type="protein sequence ID" value="AKH82500"/>
        <property type="gene ID" value="AA958_09935"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_09935"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2091"/>
    <dbReference type="OrthoDB" id="1552415at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00164">
        <property type="entry name" value="ABC2TRNSPORT"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="328"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH82500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="355" mass="37846" checksum="41B4666C01B4C34C" modified="2015-07-22" version="1">MKPFVSLSRAMALGLLRDRASVFFILVFPLMFLALFGVLFKDAGVSRATVVQVGAVEVFDEMSAKARAGLDDVLEIEKTGDRAEALQKVRDGDADAAVWEEPGGEVQMRVSAADPVQAGSVGGVLRSVVDQASIAATGQPPAYTLTGGQVEDESLQAIQYFTPGLLGWAVAMGGVFSAALGLVSWRKKRILRRLWLAPVRAGPVISARLGVNMLLAFAQTAIFLLVATVPYYGLKLTGDWWLVIPLVACGSVAFLSIGFAIGAWAKTEDAANGLAQIVVLPMAFLSGSFFPLDEAPPWVQKTSEALPLKHLVQAMQDVLTRGGSWSDALPTMGVLLLTAAVFTALAHRLFRWDAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N1Z6</accession>
    <name>A0A0F7N1Z6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_00350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH80872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014238.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_00350"/>
    <dbReference type="EnsemblBacteria" id="AKH80872">
        <property type="protein sequence ID" value="AKH80872"/>
        <property type="gene ID" value="AA958_00350"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_00350"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.85"/>
    <dbReference type="OrthoDB" id="447734at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519698" evidence="1">
        <location>
            <begin position="24"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH80872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="424" mass="45828" checksum="78AE3AB5256E4E91" modified="2015-07-22" version="1">MRKSTIRILTVCAVGALGLTACGDDGGGGDGDGGATTIKLVAADYGDKASNASKVYWDDVVKRFEAKHKDIRVDVQVINWNDIDTKVKTMIQGGNVPDVLQTGGYADKVADDLLYEADEVLSPKTKSNLIESFAKAGEVDGTQYGIPFVSSARLMFYNKDVLDEAGVEVPRTWDDVAAAAEKIKDEKAAEIPYALPLGPEETQGESMIWEIGNGGGYTDAEGNYTIDSAQNVETFEWLKENLVDPGLTYENPATTDRKTAFADFAAGKVGMLNGHPTLIQMAKDGGVDYEVAPIPGKDGPLDSTLGVADWMMAFKDGGKQEEIRKFLDFAYAKENTLKFDEMYNLMPVTTDTLEEMQSSGKHKDLEPFFEVLPAAQFYPLGSTSWDVVSAEIKKSGGKAVSDDPSKVLGELQQKAEETAADMGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N237</accession>
    <name>A0A0F7N237_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha-L-arabinofuranosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_07310</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 51 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015416.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_07310"/>
    <dbReference type="EnsemblBacteria" id="AKH82066">
        <property type="protein sequence ID" value="AKH82066"/>
        <property type="gene ID" value="AA958_07310"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_07310"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1531"/>
    <dbReference type="OrthoDB" id="620389at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046373">
        <property type="term" value="P:L-arabinose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010720">
        <property type="entry name" value="Alpha-L-AF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06964">
        <property type="entry name" value="Alpha-L-AF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00813">
        <property type="entry name" value="Alpha-L-AF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-L-AF_C" evidence="3">
        <location>
            <begin position="292"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH82066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="513" mass="56427" checksum="1140545BAD78A2F3" modified="2015-07-22" version="1">MPHTARFTVDPEFVIGEVDPRLYGTFVEHMGRCVYTGIYEPGHPTADAAGFRGDVAALVRELGTGLVRYPGGNFVSGYHWEDGVGPVAERPRRLDLAWRSVETNEVGTNEFLTWARGLGLEPMMAVNLGTRGIDAARTLVEYCNHPGGTAWSDLRIKHGVTEPHGVRLWCLGNEMDGPWQTGHKSAREYGRLAAEAGKAMHQVDPSIELVACGSSNAQMATFGTWEREVLEETYDEVDYLSLHAYYEELDGDRASFLASGAHMDQYISDVVSTADHVRAVRRADKRIRLSFDEWNVWYAARFPGERNLATAETPRLIEDTYSVTDAAVVGSLLITLLRHADRVAVACLAQLVNVIAPIRSEPGGPAWRQTVFHPFAQAARFARGTVLRTEADRKGSRIETPRHGDVPALDHVVTYDEESGDLTILAVNRAQDEPLRLSVALRGFGKDGGADGYSVIEHLVLADDDPDAANTETDPGRVLPRSLSTTRISADGELEAELPCVSWNVLRLRKRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N240</accession>
    <name>A0A0F7N240_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_00740</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH80937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014303.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
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        <property type="protein sequence ID" value="AKH80937"/>
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    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_00740"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.168"/>
    <dbReference type="OrthoDB" id="1086535at2"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="264"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="321"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH80937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="371" mass="37176" checksum="A97D291963E4B26B" modified="2015-07-22" version="1">MTTPAAGSPHGAAPAPVPTQAPPEAPEAGGSGTNRVLFGPVVLGLFLVLAFAGLMIPGLRNPAPSDMPLGLAGPGPAVAQVEAELDAAAPGAFEVKRYADEAEARTALREQDVLGAIVVGPSPKQPPALLVASAAGDAPKTAATTAYEQLTAQLGTPQKVDDVAPLPEKDSRGVSAVLLCVALTIGALIFQLVLSLAAAHVGAARRWLSCLCYAVVAGVAGALFAGPVTGTLDGHFLELLGVTTLLSLAVVGVVAACQALLGALGIAVGALLVLPLGLASSGGVVDPHFQPAFYGAVSEYLPMGSTVSLLRRVLYFDGNAAGGPLLTLALWAAGAWLVTVAMERIRPFRPLMVIVPAAAVAPARTASARTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2M3</accession>
    <name>A0A0F7N2M3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AA958_01840</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014481.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH81117">
        <property type="protein sequence ID" value="AKH81117"/>
        <property type="gene ID" value="AA958_01840"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_01840"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.400"/>
    <dbReference type="OrthoDB" id="856767at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="327"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="373"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="416"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="442"/>
            <end position="468"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="724"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="777"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="810"/>
            <end position="833"/>
        </location>
    </feature>
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        <location>
            <begin position="25"/>
            <end position="241"/>
        </location>
    </feature>
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        <location>
            <begin position="306"/>
            <end position="399"/>
        </location>
    </feature>
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        <location>
            <begin position="753"/>
            <end position="839"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH81117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="851" mass="87324" checksum="5F1B325EEA7B1A11" modified="2015-07-22" version="1">MSGTRASLRLSMAGLRTHKRRFAGTFFAVLLGVAFLGGTLVMGDTLRSSFDAMFGRATGGTDAVVRGDDMITTPGESFGTRRTVPTELADEIARMPGVAAAEPRIEGPGQLLGKDGEPVGGGGPPTLAGNWIADEELNSYRIDEGRAPERSGEAVINRGAAKDAGLGVGDTTTVRTPDPLKVTIVGISTFGGEDGMGQTSFTALTRADAEKYLTAEPGRATSIQVRADPGESQAALVKALAPALPDGIEAVTGQEVTEENQDQIAGQFLSGFTAGLLGFAGVAMLVATFSIYNTFAIVVAQRTRDNALLRALGATRRQVVGQTMAEALVVAVLASLAGLTGGVGIAAGLQALFPAVGFPFPDGDLVISGLSLALPFATGVVVCLASALAPAVRAGRTSPLAALRETAVDDSGSSRVRALVGGVLTAAGAVLTVYGASSGPSVMLTVLGAVVTLAAFVVLGPVASSYAVRILGAPLRRMNGRLARRNALRSPKRTAATATALMIGVAVVSLFTVFGASLKSTMDQTVSRAFAGDVAVRVPAFGPESGALSPKVAPAVAELPEVEHALGLGSGVARVDGDGRALTVTDPGRMGDVLDLGTVRGSLTDLGTDGVAVSRSEADDHGWQVGSTARFTFTDGEKRPFTVRAVYDQADLAGDYVLTREAWEPHRMQDSDSMVAVAFKDGVAEADGKAAVEKVAERYGNPEVQTRDEFAESSAAGVDMMLTLVYALLALAVLIALLGIANTLTLAVHERTRELGLLRAVGQTRAQLRAMVRWESVLVAAFGTAGGLTLGAFLGWAMTKATDSSGDGVFTVPPLQLAIVALVGLTAGALAAWRPSRRAAGLDVLGAIATE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2N3</accession>
    <name>A0A0F7N2N3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA small subunit methyltransferase A</fullName>
            <ecNumber evidence="6">2.1.1.182</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">16S rRNA dimethyladenosine transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">16S rRNA dimethylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rsmA</name>
        <name evidence="6" type="synonym">ksgA</name>
        <name evidence="9" type="ORF">AA958_12105</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>adenosine(1518)/adenosine(1519) in 16S rRNA + 4 S-adenosyl-L-methionine = 4 H(+) + N(6)-dimethyladenosine(1518)/N(6)-dimethyladenosine(1519) in 16S rRNA + 4 S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:19609"/>
            <dbReference type="Rhea" id="RHEA-COMP:10232"/>
            <dbReference type="Rhea" id="RHEA-COMP:10233"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74493"/>
            <dbReference type="EC" id="2.1.1.182"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.182" evidence="6"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016190.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_12105"/>
    <dbReference type="EnsemblBacteria" id="AKH82855">
        <property type="protein sequence ID" value="AKH82855"/>
        <property type="gene ID" value="AA958_12105"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_12105"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2547"/>
    <dbReference type="OrthoDB" id="2030110at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052908">
        <property type="term" value="F:16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00607">
        <property type="entry name" value="16SrRNA_methyltr_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001737">
        <property type="entry name" value="KsgA/Erm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023165">
        <property type="entry name" value="rRNA_Ade_diMease-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020596">
        <property type="entry name" value="rRNA_Ade_Mease_Trfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020598">
        <property type="entry name" value="rRNA_Ade_methylase_Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011530">
        <property type="entry name" value="rRNA_adenine_dimethylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727">
        <property type="entry name" value="PTHR11727"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00398">
        <property type="entry name" value="RrnaAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00650">
        <property type="entry name" value="rADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00755">
        <property type="entry name" value="ksgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01131">
        <property type="entry name" value="RRNA_A_DIMETH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51689">
        <property type="entry name" value="SAM_RNA_A_N6_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="4 6 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="rADc" evidence="8">
        <location>
            <begin position="42"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH82855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="298" mass="31322" checksum="C105368D62E95EAA" modified="2015-07-22" version="1">MSATTGEPDPLLGPADVRELAAALGVRPTKQRGQNFVIDPNTVRRIVRAAGVRPDDVVVEIGPGLGSLTLALLQAAAHVTAVEIDDVLAAALTATVRARLPRRAEHFALLHADALRVTELPGPPPTALVANLPYNVAVPVLLHMLATFPGIERTLVMVQAEVADRLAAAPGSKVYGVPSLKAAWYADVKRAGAIGRTVFWPAPNVDSGLVSLIRREPPATHATRTEVFAAVDAAFAQRRKTLRAALTGWAGSAPAAEAALRAAGVSPQARGESLTIEDFARIAESRQHRTATTRSSTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2S4</accession>
    <name>A0A0F7N2S4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_05095</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015028.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH81673">
        <property type="protein sequence ID" value="AKH81673"/>
        <property type="gene ID" value="AA958_05095"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_05095"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1068"/>
    <dbReference type="OrthoDB" id="1654295at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013196">
        <property type="entry name" value="HTH_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028349">
        <property type="entry name" value="PafC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018356">
        <property type="entry name" value="Tscrpt_reg_HTH_DeoR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026881">
        <property type="entry name" value="WYL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08279">
        <property type="entry name" value="HTH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13280">
        <property type="entry name" value="WYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016838">
        <property type="entry name" value="PafC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00894">
        <property type="entry name" value="HTH_DEOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="5">
        <location>
            <begin position="4"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="164"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="164"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH81673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="373" mass="39285" checksum="2D2DC6234ADDDA5C" modified="2015-07-22" version="1">MSDTPARLLTLLSVLQSGREHSGPELARRLGVSVRTVRRDVDRLRALGYPVAATVGAAGGYRLAAGTAMPPLLLDDDEAVAVAAGLRAVAAGGVEGIGETSARALAKLEQVLPARLRRRVSALQRVTVPLTVSPAGAVAATGAPVAAEVLAVLAAASSRGEGLRFGYRGKRGGDASEGRAADRVREGRPGPRSAPPAAGPGGRPPGEGRTGPDGGTRRHVEPYRLVSTGQRWYLVAYDRDRADWRTFRVDRIDDPQPTGVRHPPRELPAADAAAFVAESVAGHRGRYRAVVTLYVSLDEAVRRLPRGAGLLEAAGPGRCTLVTGGDALDWLAVRIALLGVDFEVREPPELADFLRDLGDRISRSCPPPPPRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N343</accession>
    <name>A0A0F7N343_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Putative gluconeogenesis factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_05710</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Required for morphogenesis under gluconeogenic growth conditions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the gluconeogenesis factor family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015131.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_05710"/>
    <dbReference type="EnsemblBacteria" id="AKH81778">
        <property type="protein sequence ID" value="AKH81778"/>
        <property type="gene ID" value="AA958_05710"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_05710"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1195"/>
    <dbReference type="OrthoDB" id="665169at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043743">
        <property type="term" value="F:LPPG:FO 2-phospho-L-lactate transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10680">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00973">
        <property type="entry name" value="Gluconeogen_factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002882">
        <property type="entry name" value="CofD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038136">
        <property type="entry name" value="CofD-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010119">
        <property type="entry name" value="Gluconeogen_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30135">
        <property type="entry name" value="PTHR30135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01933">
        <property type="entry name" value="CofD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142338">
        <property type="entry name" value="SSF142338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01826">
        <property type="entry name" value="CofD_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH81778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="344" mass="36742" checksum="453B2B11D57165BA" modified="2015-07-22" version="1">MRRIAGGRNLRLRRRGARRPGSQPKVVALGGGMGLSASLAALRRITGDLTAVVTVADDGGSSGRLRAELGVLPPGDLRKALAALCGDDDWGQTWSRVIQHRFTSQGELHDHAVGNLLIVALWEQLGDHVAALDLVGTLLGAHGRVLPMSAVPLELRADVRGHAPERPEQVTTVAGQATVALTPGEVQQVYLVPADPPAVPAAVEAVREADWVVLGPGSWFSSVIPHLLVPDLRQALVETKARKVLSLNLAPQPGETDGFSPQRHLEVLRRHAPKLALDVVLADKDAVPGAAERDGLREAAKELEGSVELAPVARTDGTPRHDPELLAAAYDRIFRMHGRIGPWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N395</accession>
    <name>A0A0F7N395_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 14">Pyruvate kinase</fullName>
            <ecNumber evidence="5 14">2.7.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">AA958_06020</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + pyruvate = ADP + H(+) + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:18157"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.40"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the pyruvate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.40" evidence="5 14"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015186.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_06020"/>
    <dbReference type="EnsemblBacteria" id="AKH81833">
        <property type="protein sequence ID" value="AKH81833"/>
        <property type="gene ID" value="AA958_06020"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_06020"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1258"/>
    <dbReference type="OrthoDB" id="1098983at2"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00188"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004743">
        <property type="term" value="F:pyruvate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.33.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001697">
        <property type="entry name" value="Pyr_Knase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018209">
        <property type="entry name" value="Pyrv_Knase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015793">
        <property type="entry name" value="Pyrv_Knase_brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015795">
        <property type="entry name" value="Pyrv_Knase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036918">
        <property type="entry name" value="Pyrv_Knase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015806">
        <property type="entry name" value="Pyrv_Knase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11817">
        <property type="entry name" value="PTHR11817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00224">
        <property type="entry name" value="PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02887">
        <property type="entry name" value="PK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01050">
        <property type="entry name" value="PYRUVTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="SSF50800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52935">
        <property type="entry name" value="SSF52935"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01064">
        <property type="entry name" value="pyruv_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00110">
        <property type="entry name" value="PYRUVATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12 14" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="9 14 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="11 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13 17" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PK" evidence="15">
        <location>
            <begin position="1"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="PK_C" evidence="16">
        <location>
            <begin position="356"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AKH81833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="477" mass="51463" checksum="378CF4A6A819AB94" modified="2015-07-22" version="1">MRRAKIVCTLGPATDTYDQIKGLVEAGMDVARFNLSHGTYAEHEERYARVRKAADETGRSVGVLADLQGPKIRLGTFREGPVFLERGDEFTISVDPVEGDRQCCGTTYAGLAADVGRGERILVDDGRVTLEVTAVDGPRVRTMVIEGGMVSDHKGLNLPGVAVSVPALSTKDRDDLRWALRAGADIIALSFVRSGQDVRDVHRIMDEEGRRVPVIAKVEKPQAVENLEGIVDAFDGLMVARGDLGVEMPLEQVPMVQKRAVKLAKRNAKPVIVATQMLDSMIEASRPTRAEASDVANAVMDGTDAVMLSGETSVGKYPIQTVRTMGRIVQAAEEEMLAKGLPPLTERSKPRTQGGAVARAAAEIGDFLGARYLVAFTQSGDTVRRLSRYRSPIPVLAFTPDPATRSMLNLTWGVETFLGPMVQTTDEMVAQVDEQLLKIGRCRKGDVVVITAGSPPGIPGSTNLVRVHRIGEDDPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3C2</accession>
    <name>A0A0F7N3C2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">(2Fe-2S)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_14035</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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    <dbReference type="STRING" id="444103.AA958_14035"/>
    <dbReference type="EnsemblBacteria" id="AKH83170">
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        <property type="gene ID" value="AA958_14035"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_14035"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2954"/>
    <dbReference type="OrthoDB" id="1681886at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
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        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="4">
        <location>
            <begin position="9"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH83170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="109" mass="11737" checksum="07DD2F3928A72AB1" modified="2015-07-22" version="1">MPDTGNTTYVRVARSGQVPEGVVRRFFVGDTELAVSRFEGEVYASANYCTHLACHLSSGKVTEDGLLCSCHGSVFDFATGEPLSPPAVKPIKVYEVREENGEILVAGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4H3</accession>
    <name>A0A0F7N4H3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Condensation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_12305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH82886">
        <property type="protein sequence ID" value="AKH82886"/>
        <property type="gene ID" value="AA958_12305"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_12305"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2587"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Condensation" evidence="1">
        <location>
            <begin position="13"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="500" mass="54206" checksum="3F1DFE443B0416CE" modified="2015-07-22" version="1">MPRERAEKVIPLVIVPAGPLDPHHVQQALEQLVLRHEALRSRILLDVEADGRWVQQVLAHEDVTGSLAVFVPVTTGAEVRQHARSAPLPVEPTQEAVRAMICIRDGVVCLLKISLSHVFTDAIGARAVENDLRALLARDGVVLPPAPQASSFARGPADPTVRANTERWQALLARAPRTCTFAPASRESHERVEHAVLPLPAASTRGLAAFCEGSGRPASLVWTAIGSALVQILTGQCDQVFRSTYGNRTRPDSLAAVAQLAQATYVPLQGSACDSFRNRLDMIARAVLPTYRLGEYDANALLDWLNAPENARGTVFQPAFEMNYVPPMPGDAAERGDPVSAETYQSWMRIDPLAGKADLALSITHEPDPVLLLSARRPLALHRGAEQLAQDCLQLLRALITSPDSRIAVSGVSRLHTLAGLTPHHSGAMIDLEAIERMVLSVPGVRSCRLSIRRCGEACSVHAHVHGRNFGGPENLLSLLRSRQRWHSGCVVPDSIDLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4Q1</accession>
    <name>A0A0F7N4Q1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">4-hydroxy-2-oxovalerate aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_17020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016934.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_17020"/>
    <dbReference type="EnsemblBacteria" id="AKH83630">
        <property type="protein sequence ID" value="AKH83630"/>
        <property type="gene ID" value="AA958_17020"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_17020"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3579"/>
    <dbReference type="OrthoDB" id="1797448at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005000">
        <property type="entry name" value="Aldolase/citrate-lyase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03328">
        <property type="entry name" value="HpcH_HpaI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HpcH_HpaI" evidence="1">
        <location>
            <begin position="15"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="252" mass="26602" checksum="27D391244F075206" modified="2015-07-22" version="1">MPPRTTDRRRAYAAWLSDPSFAAAEIVAATGYGAVVLDIEHGAFDLADLERFIPFLRRLDLDVLAKVLGPERGPIQQALDFGATAVVVPHVENAAHAAEVCAYGKFPPLGDRSFAGGRTAGYGGFDDDWIARQDRGTRVYPMIEDAGAIEEIGKILDLPVVDGVFVGPSDLSMRRARGAYTRSEADFADLAAIADAARAAGKPWVLPAWSAAEKAFALAHGADQLVLTMQHGALLAGFGAAVAETDALAGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4S1</accession>
    <name>A0A0F7N4S1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Type II secretion system protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_13025</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016329.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_13025"/>
    <dbReference type="EnsemblBacteria" id="AKH82996">
        <property type="protein sequence ID" value="AKH82996"/>
        <property type="gene ID" value="AA958_13025"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_13025"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2741"/>
    <dbReference type="OrthoDB" id="1835396at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018076">
        <property type="entry name" value="T2SS_GspF_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00482">
        <property type="entry name" value="T2SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="7">
        <location>
            <begin position="179"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH82996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="314" mass="33673" checksum="E4188E5C51A97317" modified="2015-07-22" version="1">MEFQGADTLTYSVVIGAVMGLGIYLLVRAIAPGRRGAVATVARVDALRARGSGRTVTSSPQQQEEGRFGGLRAQVGERAAEFYLRQGWEQRSLRSDLAVLDRSWESFLATKVLLSAVGLVFGPGVYALISVAGFGLNPVIPVWLALVAALLFFLLPDLEVRRDAADKRKDLRRVVGAYLDLVAMNLAGGRGLPEALMAAADISDGWALRRVRNALADARITGTSQWQALGNLGDELGIEELKDLSASLALVSDDGAKVRESLAARAETMRHRELAEIEGAAGEKSQSMLVAQLLLCAGFLVFLVYPAAIRVLQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4V3</accession>
    <name>A0A0F7N4V3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">Heme chaperone HemW</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AA958_09375</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015750.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_09375"/>
    <dbReference type="EnsemblBacteria" id="AKH82404">
        <property type="protein sequence ID" value="AKH82404"/>
        <property type="gene ID" value="AA958_09375"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_09375"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1978"/>
    <dbReference type="OrthoDB" id="1130951at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004109">
        <property type="term" value="F:coproporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006779">
        <property type="term" value="P:porphyrin-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034505">
        <property type="entry name" value="Coproporphyrinogen-III_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004559">
        <property type="entry name" value="HemW-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13932">
        <property type="entry name" value="PTHR13932"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00562">
        <property type="entry name" value="HemN-like__clustered_with_heat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00539">
        <property type="entry name" value="hemN_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="7 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="10">
        <location>
            <begin position="24"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AKH82404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="406" mass="43564" checksum="2191211740A50AD2" modified="2015-07-22" version="1">MPSVLPDGEPAPEDGTLPAEALAGAAGRPLGFYAHVPYCATRCGYCDFNTYTASELRGTSRDDYAATFAEEVRLARKVLGDDPREVETVFFGGGTPTLLPAADLGRMLAAIRSEFGLAADAEVTTEANPESVDPAYLAELREAGFNRISFGMQSAREHVLRVLDRTHTPGRPEACVAEARAAGFAHVNLDLIYGTPGETDDDWRASLAAALAAGPDHVSAYALIVEEGTQLARRIRRGEVPPTDDDVHADRYLIAEEVLSAAGMEWYEVSNWAVPGEGARCRHNELYWTGADWWGAGPGAHSHVGGVRWWNVKHPGPYASALAAGRSPAAGREVLTEEDRRVERILLELRLSAGCPASLLRPAGAEAASRAVGDGLLERGPYEEGRLVLTLRGRLLADGVVRDLVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4W8</accession>
    <name>A0A0F7N4W8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_09475</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LytR/CpsA/Psr (LCP) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015763.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_09475"/>
    <dbReference type="EnsemblBacteria" id="AKH82419">
        <property type="protein sequence ID" value="AKH82419"/>
        <property type="gene ID" value="AA958_09475"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_09475"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1998"/>
    <dbReference type="OrthoDB" id="835464at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027381">
        <property type="entry name" value="LytR/CpsA/Psr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004474">
        <property type="entry name" value="LytR_CpsA_psr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13399">
        <property type="entry name" value="LytR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03816">
        <property type="entry name" value="LytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="LytR_cpsA_psr" evidence="4">
        <location>
            <begin position="253"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="LytR_C" evidence="5">
        <location>
            <begin position="473"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH82419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="562" mass="59258" checksum="A7B62A731CC44455" modified="2015-07-22" version="1">MNDGYRGPQGHDPYQDPYARGYDPYGQQGYDYDRQGAPQEPGAEGYRDPSSGYGYDYDPYAQQPPPPRRGAVYPPQAPRAQQQHYAPQAPPPAVGYDYDYDPYGPAAHSGEQPVTPVPPDGEWGRIPQQRPPGEEPPGRGGPAHEPREYATEQFSFVEDETESSEDVIDWLKFTESRTERREEAKRRGRNRRVALLLAMVLAVLGGTGYLWATDRLPFVGGDSAPAEAAEEKRDTLVVHLHDTDGGGSATALLVNNASTGKGTTVLLPNDLAVSGDDGTATTLGQAVDEQGAGATRDAIDALLGSQIKGSWRLDTPYLEILVEGVGGVILDADATVPGAKKGEEPLVEKGEKRRLNGEQAIAYATYQADGEPQTAQLRRFGQVMQSVLKQLPSDTAGAKSLVKSMGMVLDPSLSEAELAASLASLSELAKEGAYATETLEVGGDGRPSEQATQKVVEDVLGGTVKNPGGATAARVSVENGAGSAKPAESAKVALVNGGFTFVDGGQAAEPAAASEVRYADAAAKEQAVQVAKTLGLPEKAVTKGKTPANADVVVVLGQDYEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N523</accession>
    <name>A0A0F7N523_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_09815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015821.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH82479">
        <property type="protein sequence ID" value="AKH82479"/>
        <property type="gene ID" value="AA958_09815"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_09815"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2068"/>
    <dbReference type="OrthoDB" id="1889827at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="73" mass="7555" checksum="681A275873EBDE79" modified="2015-07-22" version="1">MTAPAPFEVSHDHHLKPVEGADPDYGLAGSCSCAELPLTSEPPLAAGTPLTSEPPLAAEDNLISEPLPPVHFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N553</accession>
    <name>A0A0F7N553_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Pyrroline-5-carboxylate reductase</fullName>
            <shortName evidence="2">P5C reductase</shortName>
            <shortName evidence="2">P5CR</shortName>
            <ecNumber evidence="2 3">1.5.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">PCA reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">proC</name>
        <name evidence="6" type="ORF">AA958_17925</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-proline + NAD(+) = 1-pyrroline-5-carboxylate + 2 H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:14105"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15893"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="EC" id="1.5.1.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 3">
            <text>L-proline + NADP(+) = 1-pyrroline-5-carboxylate + 2 H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:14109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15893"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="EC" id="1.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 3">Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2 3">Belongs to the pyrroline-5-carboxylate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.2" evidence="2 3"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017077.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_17925"/>
    <dbReference type="EnsemblBacteria" id="AKH83775">
        <property type="protein sequence ID" value="AKH83775"/>
        <property type="gene ID" value="AA958_17925"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_17925"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3775"/>
    <dbReference type="OrthoDB" id="1349288at2"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00361"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004735">
        <property type="term" value="F:pyrroline-5-carboxylate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01925">
        <property type="entry name" value="P5C_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029036">
        <property type="entry name" value="P5CR_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000304">
        <property type="entry name" value="Pyrroline-COOH_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645">
        <property type="entry name" value="PTHR11645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14748">
        <property type="entry name" value="P5CR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000193">
        <property type="entry name" value="Pyrrol-5-carb_rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00112">
        <property type="entry name" value="proC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00521">
        <property type="entry name" value="P5CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0521">NADP</keyword>
    <keyword evidence="2 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 3" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F420_oxidored" evidence="4">
        <location>
            <begin position="4"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="P5CR_dimer" evidence="5">
        <location>
            <begin position="160"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH83775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="275" mass="29161" checksum="1A7C4359C97FB57B" modified="2015-07-22" version="1">MTQKVAVLGAGKIGEALLSGMIRAGWSPGDLLVTARRQDRAEELRHRYGVEPVSNGDAAKRADTLILTVKPQDMGTLLDDLAPHVPADRLVVSAAAGIPTDFFEERLPEGAPVVRVMPNTPVLVDEGMCVISAGKHAVEQHLARTEEIFKPVGKTLRVPEAQQDAATALSGSGPAYFYFLVEAMTDAGILLGLPREKAHDLIVQAAIGAAVMLRDSGEHPVKLREAVTSPAGTTINAIRELENHGVRAALIAAIEAARDRSRELGTGPAPDAKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5E3</accession>
    <name>A0A0F7N5E3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LuxR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_07140</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015382.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_07140"/>
    <dbReference type="EnsemblBacteria" id="AKH82032">
        <property type="protein sequence ID" value="AKH82032"/>
        <property type="gene ID" value="AA958_07140"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_07140"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1496"/>
    <dbReference type="OrthoDB" id="930905at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="2"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="145"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH82032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="216" mass="23784" checksum="9CCC4EC9B24CEB88" modified="2015-07-22" version="1">MRAVIAEDLFLLRDGLVRMLEAYDFEILAAVDNGPELARALDELEPDVAVVDVRLPPSFSDEGLQCALQARAKRPGLPVLVLSQHVEQLYARELLADERGGVGYLLKDRVFDADQFIDAVRRVAGGGTAMDPQVISQLLSRRAAQDQPVNTLTPREREVMELMAQGRSNAAIAERLVVTERAVAKHTSNIFSKLGLPPSDDDNRRVLAVLAYLDRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5F3</accession>
    <name>A0A0F7N5F3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_07215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015397.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_07215"/>
    <dbReference type="EnsemblBacteria" id="AKH82047">
        <property type="protein sequence ID" value="AKH82047"/>
        <property type="gene ID" value="AA958_07215"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_07215"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1512"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="79" mass="8596" checksum="3858A5F4AA8C5554" modified="2015-07-22" version="1">MPSEPRKTPSLLAQADRLAVFTAVVCVLSVAAAVVSFAKGYWIGAVWVLLAGLSSNMTWFYVRRARLARARDRDEGPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5N1</accession>
    <name>A0A0F7N5N1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_07685</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015482.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_07685"/>
    <dbReference type="EnsemblBacteria" id="AKH82132">
        <property type="protein sequence ID" value="AKH82132"/>
        <property type="gene ID" value="AA958_07685"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_07685"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1615"/>
    <dbReference type="OrthoDB" id="1361974at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005583">
        <property type="entry name" value="YaaA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30283">
        <property type="entry name" value="PTHR30283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03883">
        <property type="entry name" value="H2O2_YaaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH82132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="265" mass="27938" checksum="A5762C5B8B95A81F" modified="2015-07-22" version="1">MLVLLPPSEGKAEGRRGAPLKLDSLSLPGLTAARETVLDELVALCAADEEKAADVLGLTEGLRGEVARNARLRTAPTRPAGQVYTGVLYDALGLATLDAAAKRRASASLLVFSGLWGAVRIGDRIPAYRCSMGVRLPAAGALGAYWRGPLDAALPAAAGRGLVLDLRSSAYATAWRPRGDLAARTAAVRVLHATVVDGVEKRSVVSHFNKATKGRLLRDLLTSGAKPRTPAALLTALRDLGYRVEGDPPRRAGQPWELDVVVTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5T3</accession>
    <name>A0A0F7N5T3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polyketide cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_07955</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AHA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015527.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_07955"/>
    <dbReference type="EnsemblBacteria" id="AKH82177">
        <property type="protein sequence ID" value="AKH82177"/>
        <property type="gene ID" value="AA958_07955"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_07955"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1675"/>
    <dbReference type="OrthoDB" id="1914312at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013538">
        <property type="entry name" value="Activator_of_Hsp90_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08327">
        <property type="entry name" value="AHSA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="144" mass="15908" checksum="7E1305BF196255C4" modified="2015-07-22" version="1">MTGDRIEREIVIAAAPEKVWPLVAEPGFWATDDESIRGTQAAAGQSLVARHSEHGDFPMRVEKADPPKYLAYRWVSAFPGEELREDNSTLVEFTLTPEGDGTRLRVVESGFAALPTSEDNRRNVINDHTAGWEQCLAALTARAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N718</accession>
    <name>A0A0F7N718_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_14170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016516.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_14170"/>
    <dbReference type="EnsemblBacteria" id="AKH83188">
        <property type="protein sequence ID" value="AKH83188"/>
        <property type="gene ID" value="AA958_14170"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_14170"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2983"/>
    <dbReference type="OrthoDB" id="1866297at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025591">
        <property type="entry name" value="RloB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13707">
        <property type="entry name" value="RloB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH83188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="223" mass="25242" checksum="14E92F877ACA0DA3" modified="2015-07-22" version="1">MARSKGRDSLGPAKQRGRRHRVVHVFTEGEVTEPHYIDIIKERGTYADSVMPVAVRIANQNAPGSQRKPVKLVEAAVKLMREERRAAKREGLKKEFWPQVWCLFDRDQHEHVETALKEAREADVRVAFSHPCFEIWRVLHHKPVTGTFNGVCGEATARLPYATSAANIKVVLPEQIVHGSFEQAKKRARQMNAAHGDHVPLSNRDPYTDVFTFVEDGLGIVSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N769</accession>
    <name>A0A0F7N769_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidoglycan glycosyltransferase</fullName>
            <ecNumber evidence="1">2.4.1.129</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AA958_14505</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23708"/>
            <dbReference type="Rhea" id="RHEA-COMP:9602"/>
            <dbReference type="Rhea" id="RHEA-COMP:9603"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:78435"/>
            <dbReference type="EC" id="2.4.1.129"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.4.1.129" evidence="1"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016558.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_14505"/>
    <dbReference type="EnsemblBacteria" id="AKH83243">
        <property type="protein sequence ID" value="AKH83243"/>
        <property type="gene ID" value="AA958_14505"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_14505"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3054"/>
    <dbReference type="OrthoDB" id="652304at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008955">
        <property type="term" value="F:peptidoglycan glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3810.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001264">
        <property type="entry name" value="Glyco_trans_51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036950">
        <property type="entry name" value="PBP_transglycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00912">
        <property type="entry name" value="Transgly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="Transgly" evidence="11">
        <location>
            <begin position="78"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="10">
        <location>
            <begin position="362"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="675"/>
            <end position="755"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AKH83243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="755" mass="80063" checksum="4AD11D016072830F" modified="2015-07-22" version="1">MAYKRPGGGLTATQQAAKFLGVSVLAGSVLAGLALPAAGLLGLTAKGTVAEFDDIPADLKRPPLSQKTTILDREGGHLADVYSRNRTVVEFDDIAPVMRQAIVAIEDERFYEHGAVDLQGILRALNSNAQSGTVSEGASTLTQQYVKNLFVEEAGNDAQKVAEATRQTLGRKIQELKYAIQVEKELTKDEILENYLNIAFFGQQAYGIEAAAERYFSKSADKLTLAESAMLAGIVQSPSRYDPINNPEAAEKRRNTVLRRMAGNDNVTRAEADKAMKEPLGLKISEPRNGCITAVSGAAFFCDYVREVLLDDKGFGKTPEQRVKRWNRGGLTIRTTLDPVAQKSASESIKSHVYQDDAVATAVTMVEPGTGKIRAMGQSRPYGSGKNELMINLSVEKSMNGSNYGFQVGSTFKPLTAAAALEKGVPNTKVYPSPNEMPYPSPVETCEDGKDWVNTEGSEVANETEEEVGPYSMREATAKSINTYFVDLISEIGICPVKELAQSMGVHRGDGKDLEESPSLTLGGQTIAPLAMANAYATFANRGEYCSPVAIESIKDAKGKKVPVPKTQCKRVMSEKTAGTINTLLSGVVEDGTGKEAGLTGRDNAGKTGTTDERKAAWFVGYTADLAGAVWVGGPLDDVSMENIQIGPTYHDRVFGGAVPGPIWRDAMDGALAGKTSPELYKVPVPVDRPDKGKGDDDDEDDEDKPENPLGGLLGGSNGNGGGNGGGGPGGGTLDGGSLDGGWSDGGNGGWPDGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7F8</accession>
    <name>A0A0F7N7F8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PadR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_22620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="1">
        <location>
            <begin position="7"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="174" mass="19437" checksum="02AD249C1FE46AFF" modified="2015-07-22" version="1">MTIGHTLLGLLESGPRHGYDLKRAFDERFGHDRPLHYGQVYSTMSRLLKNGLVEVDGIEPGGGPERKRYAITDAGITDVAGWLATPEKPEPYLQSTLYTKVVLALLTGRDAAELLDVQRAEHLRLMRELTRRKKGGDLADQLICDHALFHLEADLRWLELTAARLGKLAAEVRA</sequence>
</entry>
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    <accession>A0A0F7N7T1</accession>
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    <organism evidence="5 6">
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            <authorList>
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
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            <end position="193"/>
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    </feature>
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            <end position="346"/>
        </location>
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        <location>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH84086.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="347" mass="36600" checksum="1F032B7135DDBFE0" modified="2015-07-22" version="1">MSEARIVAVTFRTPPLVKMEEFANLVAADPGGDTVAQVVRNSAITTKGMAVNALLEDPRRWTTRRRMDRSLAEARRLGRTTVTAALAEAGLGPGDVGLFATVTTTTHSAPGLDALAAELGLRPDVETLSLGPMGCYAAVPAVSACAHWVAVKRRPAVLLAVDLFSPHVQPPPYDKEQAVVLTLFGDGAAAVVLLPRDADGPGGAEVVDAEQLTAPAHADDLQVHMGDNGLRIRLKPSMPDVVAGSVAIPARALLARHGVRWTDVAWWAVHPGGRRILDRVDEALDLPERSMATAREVMREYGNTAAPAVLAVLRRLQTARPLAAGEHGVVLACGPGATVWALLLRGT</sequence>
</entry>
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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    </dbReference>
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            <end position="20"/>
        </location>
    </feature>
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            <end position="196"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82917.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="196" mass="20099" checksum="DEA2B85A95BECE31" modified="2015-07-22" version="1">MLALLAATGFTVATTGTANAAPVRLDYPLTGTTHLAGTDSDLALGPGKLETTVDLSTGALTAHTKLPPATGSFKTLDLIPATATTEFIETEPTAGTISTATGEVNTVSKLTLRITRLKVAGLPVWVGDRCQTEVPAEIALKSEPGFNPFRGGTLSGTYTIPDFEHCLLATPVINAIIPGEGNTISLKLGAAQAPTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N820</accession>
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        <submittedName>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
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            <end position="76"/>
        </location>
    </feature>
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        <location>
            <begin position="97"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="176" mass="18566" checksum="EEAE2739ACBF4DDC" modified="2015-07-22" version="1">MPPHAPPGVPAPYAPQGAPALHPHPGAAVPYPPQLYPHGPPGKPPPDSAMWAHLSALLIFIAGTGACCIGFLVAWIGPLNIRGKSGDPFVRHHGTEGLNWGITQIVAVVVFGALTGGSIYLAEEQGWPEWVPAVPMTAWGLHLVTSFAFAIIGCRRAKAGELWSYPRPVALPFTKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N876</accession>
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    <organism evidence="1 2">
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH83658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="59" mass="6591" checksum="C36E45319E39A015" modified="2015-07-22" version="1">MQVRVVEEPHLTAVHGDAYAAYTARASPFSPPSAGHGLMLTRRSRRRDQIAKSLLRTQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8E7</accession>
    <name>A0A0F7N8E7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_17730</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017045.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_17730"/>
    <dbReference type="EnsemblBacteria" id="AKH83743">
        <property type="protein sequence ID" value="AKH83743"/>
        <property type="gene ID" value="AA958_17730"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_17730"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3733"/>
    <dbReference type="OrthoDB" id="1179151at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH83743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="307" mass="33264" checksum="89187D4FCF04AA72" modified="2015-07-22" version="1">MTKAITVSGLTKTFGRTRALDGLDLDVETGEVHGFLGPNGAGKSTTIRVLLGLLRADTGTAQVLGGDPWADAVTLHRRLAYVPGDVELWPNLTGGEAIDLLARLRGGIDKQRRDDLIERFDLDPTKKGRSYSKGNRQKVAIVAALASDAELLLLDEPTAGLDPLMEVIFQDVITQAKAEGKTVLLSSHILAQVEKLADRVSIIRLGKIVQSGTLSEMRHLTRTTIEAETEQPATGIDQLPGIHQLRTDDGRVHFAVDGEHLDAAVRRLGEFGIRSLVSHPPTLEELMLRHYGDELEHNGHHSEAGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8L4</accession>
    <name>A0A0F7N8L4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">tRNA(Ile)-lysidine synthase</fullName>
            <ecNumber evidence="6">6.3.4.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">tRNA(Ile)-2-lysyl-cytidine synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">tRNA(Ile)-lysidine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">tilS</name>
        <name evidence="10" type="ORF">AA958_18080</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>ATP + cytidine(34) in tRNA(Ile2) + L-lysine = AMP + diphosphate + H(+) + lysidine(34) in tRNA(Ile2)</text>
            <dbReference type="Rhea" id="RHEA:43744"/>
            <dbReference type="Rhea" id="RHEA-COMP:10625"/>
            <dbReference type="Rhea" id="RHEA-COMP:10670"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:83665"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.4.19"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="6">The N-terminal region contains the highly conserved SGGXDS motif, predicted to be a P-loop motif involved in ATP binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the tRNA(Ile)-lysidine synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.19" evidence="6"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017099.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_18080"/>
    <dbReference type="EnsemblBacteria" id="AKH83799">
        <property type="protein sequence ID" value="AKH83799"/>
        <property type="gene ID" value="AA958_18080"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_18080"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3802"/>
    <dbReference type="OrthoDB" id="666797at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016879">
        <property type="term" value="F:ligase activity, forming carbon-nitrogen bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01992">
        <property type="entry name" value="PP-ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01161">
        <property type="entry name" value="tRNA_Ile_lys_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011063">
        <property type="entry name" value="TilS/TtcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012094">
        <property type="entry name" value="tRNA_Ile_lys_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012795">
        <property type="entry name" value="tRNA_Ile_lys_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015262">
        <property type="entry name" value="tRNA_Ile_lys_synt_subst-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43033">
        <property type="entry name" value="PTHR43033"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01171">
        <property type="entry name" value="ATP_bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09179">
        <property type="entry name" value="TilS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02432">
        <property type="entry name" value="lysidine_TilS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="ATP_bind_3" evidence="8">
        <location>
            <begin position="82"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="TilS" evidence="9">
        <location>
            <begin position="309"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="32"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="87"/>
            <end position="92"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AKH83799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="390" mass="40728" checksum="36AED2EB83BBDED1" modified="2015-07-22" version="1">MGPHPAVAAIRLAVRHVLHDVLTEHATAHVPPTPAAFPAAPQASPAASTVSTAAGPPPAARARFAGTSRPAAPTAPAAAPLILVACSGGADSMALASALSFEAPRQGARAGGITIDHGLQAGSDLRAQEVVGRMRALGLDPVESVRVDVGRGGGPEAAAREARYAALDEAAQRLGAAAVLLGHTRDDQAETVLLALARGSGVRSLSGMAATSGPGGRYRRPFLQIDRQVARKACMVQSLPVWDDPHNVDPAYTRSRVRHEALPVLEKALGRGVVASLARTARLSRDDADALDAWAADAERGVRDADGGLDVPGLYALPPAVRRRVLRRAALAAGSPAGSLFSRHIEEMDKLITGWRGQSALNLPGRVSARREQGRLVVRREYRREDDGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8S3</accession>
    <name>A0A0F7N8S3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable phosphoketolase</fullName>
            <ecNumber evidence="5">4.1.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_13840</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the XFP family.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.-" evidence="5"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016465.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_13840"/>
    <dbReference type="EnsemblBacteria" id="AKH83137">
        <property type="protein sequence ID" value="AKH83137"/>
        <property type="gene ID" value="AA958_13840"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_13840"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2914"/>
    <dbReference type="OrthoDB" id="45239at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01403">
        <property type="entry name" value="Phosphoketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023962">
        <property type="entry name" value="Phosphoketolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005593">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018969">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019790">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018970">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019789">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_ThDP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31273">
        <property type="entry name" value="PTHR31273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03894">
        <property type="entry name" value="XFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09363">
        <property type="entry name" value="XFP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09364">
        <property type="entry name" value="XFP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017245">
        <property type="entry name" value="Phosphoketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS60002">
        <property type="entry name" value="PHOSPHOKETOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS60003">
        <property type="entry name" value="PHOSPHOKETOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="XFP_N" evidence="7">
        <location>
            <begin position="3"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="XFP_C" evidence="6">
        <location>
            <begin position="580"/>
            <end position="782"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF09363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH83137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="784" mass="87000" checksum="E2CCF6A5C3EDF028" modified="2015-07-22" version="1">MKKQELADLDAHWRALNYLAAGQIYLTRNPLLTDPLTPEDIKPRLLGHWGTCPGLNLVYTHLNRVIGARDLDAVCVWGPGHGGPAVYAGAWLDGSYGEAHPDVSRDAAGMARLFRQFSFPGGTPSHVAPVIPGSFHEGGELGYSLAHAYGAAFDNPGLVAACVIGDGEAETGPLAGSWHANKFLDPAYDGAVLPILHLNGYKIAGPTVLSRIPERELDELLRGYGHEPLHVSGEDPARVHRDMADAMDTALDRIAEFQQAARARGGLRGRPRWPAIVLRTPKGWTGPEDVDGTPVEGTWRSHQVPLPNVRENPEHLAELERWLRSYEPEKLFGADGRPRPQVLACVPHGDRRLGANPHANGGRLLRALPLPGPETYAVAVDRPGGRMHEPTRVLGAMLRQVMADTAERRDFRVFGPDETASNRLQELFEVTDRAWQAETERTDEHHGPHGRVMEVLSEHLCQGWLEGYVLTGRHGLFSSYEAFAHIVASMAAQHIKWIQTAHEEPWRAPVAGLNYLLTSHVWRQDHNGFSHQDPGFVDHILNKSPGVVRVYLPPDANTLLCVADHVLRTRDVVNVVVAGKQPSFDWLTLEQARAHCLRGVGIWEWAGTERPGEAPDVVLACAGDVPTLEVLAAAALLREHLPEVAVRVVNVVDIARLMPHEDHPHGMTDREFDSVFTRDTPVIFAYHGYPWLIHRLAYRHAGHDQFHVRGYKEMGTTTTPFDMVVRNDLDRYRLVMDVVDRVPGLAVRAAAVRQRMADVRGRHHAWIREHGTDLPEVADWTWPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8V5</accession>
    <name>A0A0F7N8V5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Threonine ammonia-lyase</fullName>
            <ecNumber evidence="5">4.3.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AA958_22360</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-threonine = 2-oxobutanoate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:22108"/>
            <dbReference type="ChEBI" id="CHEBI:16763"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="EC" id="4.3.1.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-isoleucine biosynthesis; 2-oxobutanoate from L-threonine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the serine/threonine dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.19" evidence="5"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017747.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_22360"/>
    <dbReference type="EnsemblBacteria" id="AKH84486">
        <property type="protein sequence ID" value="AKH84486"/>
        <property type="gene ID" value="AA958_22360"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_22360"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4708"/>
    <dbReference type="OrthoDB" id="1876944at2"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00054"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004794">
        <property type="term" value="F:L-threonine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:threonine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04886">
        <property type="entry name" value="ACT_ThrD-II-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044561">
        <property type="entry name" value="ACT_ThrD-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005789">
        <property type="entry name" value="Thr_deHydtase_catblc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01127">
        <property type="entry name" value="ilvA_1Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0412">Isoleucine biosynthesis</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT" evidence="9">
        <location>
            <begin position="334"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AKH84486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="407" mass="41777" checksum="DF4BF1BC64A60C52" modified="2015-07-22" version="1">MSAAAAGAVSLDDVRDAQNILAGIARVTALEGSRFLSRLVDAPVHLKCENLQRTGSFKLRGAYVRIAGLGEGQRHRGVVAASAGNHAQGVALAASLLGVRSTVFMPVGAPLPKVAATLDYGADVRLHGQVVDETLEAAESYAAATGAVLIHPFDHPDVVAGQGTVGLEVLEQCPEVSTIVVGIGGGGLAAGIAVAVKAVRPDVRIVGVQAEDAAAYPPSLAAGRPVALESFGTMADGIQVGKPGDVPFKIIGEYVDEVRTVSEDALSAAVLLCLERAKLVVEPAGAAPVAALLSDPETFGGGPVVAVLSGGNVDPLLVQRILRHGMAAAGRYLSLRLRVTDRPGVLATLLGVLSEADANVLDVSHVRTDPRLGLTEAEVELQLETKGREHCDRVLAALRKAGYTVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-08-12" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NA75</accession>
    <name>A0A0F7NA75_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptide-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_28065</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018684.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH85450">
        <property type="protein sequence ID" value="AKH85450"/>
        <property type="gene ID" value="AA958_28065"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_28065"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5916"/>
    <dbReference type="OrthoDB" id="1687028at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012551">
        <property type="entry name" value="DUF1707"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08044">
        <property type="entry name" value="DUF1707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SSF49879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="105"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH85450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="178" mass="19495" checksum="EDFEE1A76D74A296" modified="2015-07-22" version="1">MYPAGTPRVSDEERDRAIELLRDGAAEGRLSQDTFLARVDLAFAAHSHEQLAALTADLPPREGRLTRAILGTVAKASSLGVRVKQAWQAERLPPLMLPAPGTLPLRIGRDPRNGLRLMEETVSRMHAELRCASGVWLLRDLGSTNGTFINGRRLTGEAPVRPGDQLGFGHTRYLLTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NA87</accession>
    <name>A0A0F7NA87_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_21950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017675.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH84413">
        <property type="protein sequence ID" value="AKH84413"/>
        <property type="gene ID" value="AA958_21950"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_21950"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4622"/>
    <dbReference type="OrthoDB" id="1394285at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025649">
        <property type="entry name" value="DUF4360"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38847">
        <property type="entry name" value="PTHR38847"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14273">
        <property type="entry name" value="DUF4360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519358" evidence="1">
        <location>
            <begin position="27"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="215" mass="22605" checksum="BEA345C5402B47D8" modified="2015-07-22" version="1">MSGKLIAGGALAALVATTLAAQTAAAGEEPADGPAEQIKVGIQTINGSGCSAGTAAVAANADNTAFTVTYSDYLAAAGAGANPIDFRKNCQLSLVLDVPAGFTYAIQSVDYRGYAYLADGASGMEQASYYHMGSPETTTSSQTFDGPYDDNWQVTDSKEWAELVWAPCGEKRNFNVNTELRVYRGSSDQQATSLMTMDSTDSAVSTKYHLAWKEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAB4</accession>
    <name>A0A0F7NAB4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Succinate--CoA ligase [ADP-forming] subunit alpha</fullName>
            <ecNumber evidence="2">6.2.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Succinyl-CoA synthetase subunit alpha</fullName>
            <shortName evidence="2">SCS-alpha</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">sucD</name>
        <name evidence="7" type="ORF">AA958_21705</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 5">Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 5">
            <text>ATP + CoA + succinate = ADP + phosphate + succinyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:17661"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.2.1.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 5">Heterotetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the succinate/malate CoA ligase alpha subunit family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.5" evidence="2"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017641.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_21705"/>
    <dbReference type="EnsemblBacteria" id="AKH84379">
        <property type="protein sequence ID" value="AKH84379"/>
        <property type="gene ID" value="AA958_21705"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_21705"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4572"/>
    <dbReference type="OrthoDB" id="1081709at2"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01988">
        <property type="entry name" value="Succ_CoA_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017440">
        <property type="entry name" value="Cit_synth/succinyl-CoA_lig_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033847">
        <property type="entry name" value="Citrt_syn/SCS-alpha_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005810">
        <property type="entry name" value="CoA_lig_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="CoA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02629">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001553">
        <property type="entry name" value="SucCS_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="SSF52210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01019">
        <property type="entry name" value="sucCoAalpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01216">
        <property type="entry name" value="SUCCINYL_COA_LIG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00399">
        <property type="entry name" value="SUCCINYL_COA_LIG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0436">Ligase</keyword>
    <keyword evidence="1 2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="CoA_binding" evidence="6">
        <location>
            <begin position="4"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Coenzyme A binding" evidence="2">
        <location>
            <begin position="17"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Coenzyme A binding" evidence="2">
        <location>
            <begin position="109"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="2 3">
        <location>
            <position position="260"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit beta</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001553-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH84379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="303" mass="31296" checksum="BDD1F86B06785807" modified="2015-07-22" version="1">MAIFLTKDSKVIVQGMTGSEGQKHTRRMLASGANVVGGVNPRKAGQKVDFDVVSETRESSTVEIPVFGSVKEAIDTTGADVTVIFVPEKFTKSAVIEAIDAEIPLAVVITEGIAVHDTAAFWAYAGAKGNKTRIIGPNCPGLITPGQSNAGIIPADITKPGRIGLVSKSGTLTYQMMYELRDIGFSTCVGIGGDPVIGTTHIDALEAFEADPDTDLIVMIGEIGGDAEERAADFIKAHVTKPVVGYVAGFTAPEGKTMGHAGAIVSGSSGTAQAKKEALEAAGVKVGKTPSETARLAREVLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAB5</accession>
    <name>A0A0F7NAB5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carbon monoxide dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_28275</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018724.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_28275"/>
    <dbReference type="EnsemblBacteria" id="AKH85490">
        <property type="protein sequence ID" value="AKH85490"/>
        <property type="gene ID" value="AA958_28275"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_28275"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5960"/>
    <dbReference type="OrthoDB" id="117507at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000674">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036856">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016208">
        <property type="entry name" value="Ald_Oxase/xanthine_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008274">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037165">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11908">
        <property type="entry name" value="PTHR11908"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01315">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02738">
        <property type="entry name" value="Ald_Xan_dh_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01008">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54665">
        <property type="entry name" value="SSF54665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56003">
        <property type="entry name" value="SSF56003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ald_Xan_dh_C" evidence="2">
        <location>
            <begin position="35"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH85490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="800" mass="84555" checksum="1B9E245A172C58EE" modified="2015-07-22" version="1">MSDVTRIPTSLTQGSRTAGGIGESKLRPDGTLKVTGEFAYSSDLWHEDMIWGHTLRSPYAHAEIVAIDTSAALAQAGVYAVLTYDDLPARQKNYGLEIADTPALAAGRVRHHGEPVALVAADHPETARRAAAKIRIEWRELPLVTDEESALAPGAPVLHPDRTDDCADGQRPHVPHPNIVHRQPIVRGDAAAAALRADHIITGEYEFGMQDQAFLGPESGLAVPAEDGGVDLYVATQWLHADRRQIAPVLGLPEEKVRMTLSGVGGAFGGREDLSMQIHACLLALRTGKPVKMVYDRFESFFGHVHRHPARIRYEHGVTAEGRITHARCRIVLDGGAYASSTPAVVGNAASLSMGPYVVEDVEIEAVGLYTNNPPCGAMRGFGAVQACFAYEAQMDRLAAAVGMDPVAFRQLNAMSEGSRLPTGQRVDSPAPVAEILRRVQARPLPPERQWESAGGTADVRALPGGLSNTTHGEGVVRGVGYAVGIKNVGFSEGFDDFSTARVRLEAVGGEPVVTVHTAAAEVGQGGITVQAQIARTELGVARVVIAPADTRVGSAGSTSASRQTYMTGGAVRNACAAVREQVLALGRRKLGTYHPAWTTAELLLEGGKVVTDGGEVLADLADVLDGEPPVDVELPFRHRPTEPFDIETGQGFGHVQYSFAAHRAVVEVDTELGLVKVVELACAQDVGKALNPLSVVGQIQGGTTQGLGVAVMEEIVVDPATGRVRNPSFTDYLIPTILDTPAIPVDVLELADPHAPYGLRGVGEASTLSATPAVLAAIRQATGLALTKAPVRPEHLTGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAE5</accession>
    <name>A0A0F7NAE5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">N-acylneuraminate cytidylyltransferase</fullName>
            <ecNumber evidence="7">2.7.7.43</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_21925</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an N-acylneuraminate + CTP = a CMP-N-acyl-beta-neuraminate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11344"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:60073"/>
            <dbReference type="ChEBI" id="CHEBI:68671"/>
            <dbReference type="EC" id="2.7.7.43"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-sugar metabolism; N-acetylneuraminate metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the CMP-NeuNAc synthase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the KdsC family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.43" evidence="7"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017671.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_21925"/>
    <dbReference type="EnsemblBacteria" id="AKH84409">
        <property type="protein sequence ID" value="AKH84409"/>
        <property type="gene ID" value="AA958_21925"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_21925"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4617"/>
    <dbReference type="OrthoDB" id="1345588at2"/>
    <dbReference type="UniPathway" id="UPA00628"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008781">
        <property type="term" value="F:N-acylneuraminate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006054">
        <property type="term" value="P:N-acetylneuraminate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003329">
        <property type="entry name" value="Cytidylyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010023">
        <property type="entry name" value="KdsC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02348">
        <property type="entry name" value="CTP_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01138">
        <property type="entry name" value="C1.6.2:_Deoxy-d-mannose-octulo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH84409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="450" mass="47019" checksum="54651791EE60EDA4" modified="2015-07-22" version="1">MSQPESAPRVLAVIPARGGSKGVPGKNLARVGGVPLVARAVRQCLAARLVTDVVVSTDDDTIASVAREAGAEVVRRPAEIAGDTASSEAAVLHALDSHEERCGATMAAVLLVQCTSPFLTGEDIDGVTSAVLDEGADSALTVAPFHGFLWRDEADEAEAAAVAETPAAKTPAVAEATAVAKAAATGAATGTATGAAPTKVAPAVETAPAQGYGVNHDKSYRPRRQDRPQDLLETGAAYAMRTPGFREHRHRFFGRTAPVRTDAARVLEVDEPDDLTRARALAPLLDVPGPGSLPTRRDVDAVVLDFDGTQTDDRVYIDAEGRELVAVHRGDGLGIAALRRAELKLLILSSEKNPVVAARARKLHLPVLHGVDRKDIALKQWCEDEGIAPERVLYVGNDVNDLPCFGLVGWPVAVAGAHAIVRDAARAVTSTPGGDGAIREIASWILGPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAM5</accession>
    <name>A0A0F7NAM5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphoribosylamine--glycine ligase</fullName>
            <ecNumber evidence="6">6.3.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">GARS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Glycinamide ribonucleotide synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Phosphoribosylglycinamide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">purD</name>
        <name evidence="9" type="ORF">AA958_17790</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>5-phospho-beta-D-ribosylamine + ATP + glycine = ADP + H(+) + N(1)-(5-phospho-beta-D-ribosyl)glycinamide + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17453"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:58681"/>
            <dbReference type="ChEBI" id="CHEBI:143788"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the GARS family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.13" evidence="6"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017054.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_17790"/>
    <dbReference type="EnsemblBacteria" id="AKH83752">
        <property type="protein sequence ID" value="AKH83752"/>
        <property type="gene ID" value="AA958_17790"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_17790"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3745"/>
    <dbReference type="OrthoDB" id="932854at2"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004637">
        <property type="term" value="F:phosphoribosylamine-glycine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00138">
        <property type="entry name" value="GARS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020561">
        <property type="entry name" value="PRibGlycinamid_synth_ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000115">
        <property type="entry name" value="PRibGlycinamide_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020560">
        <property type="entry name" value="PRibGlycinamide_synth_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037123">
        <property type="entry name" value="PRibGlycinamide_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020559">
        <property type="entry name" value="PRibGlycinamide_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020562">
        <property type="entry name" value="PRibGlycinamide_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43472">
        <property type="entry name" value="PTHR43472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01071">
        <property type="entry name" value="GARS_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02843">
        <property type="entry name" value="GARS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02844">
        <property type="entry name" value="GARS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01210">
        <property type="entry name" value="GARS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00877">
        <property type="entry name" value="purD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00184">
        <property type="entry name" value="GARS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 6 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 6" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="8">
        <location>
            <begin position="107"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH83752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="423" mass="43331" checksum="2C97FFEADA2A1518" modified="2015-07-22" version="1">MKVLVIGGGAREHALCRALSLDPGVRELHCAPGNAGIAAVARLHAVDVLDGPAVAELAAGLGADLVVVGPEAPLVAGVADAVRARGIDCFGPGAEAARLEGSKAFAKDVMAEADVPTARAYVCTTPEEADTALDAFGPPYVVKDDGLAAGKGVVVTGDLEEARAHARACTAAGQVVIEEFLDGPEVSLFAVTDGESVVPLSPAQDFKRAYDGDAGPNTGGMGAYTPLPWADPKLVDEVVETVLQPTVDEMRRRGTPFAGLLYAGLALTSRGVRVVEFNARFGDPETQAVLARLRTPLAGLLRAAAQGRLAAFPPLVWSDDAAVTVVLAAKDYPAKPRTGDVITGLDAVEAEDAPDAYVLHAGTKLDDSGHIVSAGGRVLCVTAVGADLTAARDRAYEAIRRIGLDGAHYRGDIAARAAEAAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAP0</accession>
    <name>A0A0F7NAP0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_26190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_26190"/>
    <dbReference type="EnsemblBacteria" id="AKH85136">
        <property type="protein sequence ID" value="AKH85136"/>
        <property type="gene ID" value="AA958_26190"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_26190"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="74" mass="7132" checksum="A0A49ECB1C021F34" modified="2015-07-22" version="1">MPYPGRSTGAVRWLVPPDGSGRLTDPVVLELAMHEAAAHLAGGPGGAGPAGPAGATGGGGGPVAGERRGPRRTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NB04</accession>
    <name>A0A0F7NB04_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Molybdopterin biosynthesis protein MoeE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_23520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017938.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_23520"/>
    <dbReference type="EnsemblBacteria" id="AKH84683">
        <property type="protein sequence ID" value="AKH84683"/>
        <property type="gene ID" value="AA958_23520"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_23520"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4959"/>
    <dbReference type="OrthoDB" id="1877633at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00756">
        <property type="entry name" value="MoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036563">
        <property type="entry name" value="MoaE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003448">
        <property type="entry name" value="Mopterin_biosynth_MoaE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02391">
        <property type="entry name" value="MoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54690">
        <property type="entry name" value="SSF54690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH84683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="159" mass="16946" checksum="4EB0FF8757F3C543" modified="2015-07-22" version="1">MADTPQHPGEQAAADPVRLVAIREQPLSLDEVFAAVGDPAAGGTALFVGTVRDHDRQAASERVQDVTALGYSSHPTAEAEMRRIAEKVAADYPVRALAAVHRVGELAVGDLAVVVAVSCPHRGEAFDACRSLVDTLKREVPIWKHQKFTDGTEEWVGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBJ4</accession>
    <name>A0A0F7NBJ4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glucokinase</fullName>
            <ecNumber evidence="2">2.7.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Glucose kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_28505</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ROK (NagC/XylR) family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.2" evidence="2"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018765.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_28505"/>
    <dbReference type="EnsemblBacteria" id="AKH85531">
        <property type="protein sequence ID" value="AKH85531"/>
        <property type="gene ID" value="AA958_28505"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_28505"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6006"/>
    <dbReference type="OrthoDB" id="1130699at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004654">
        <property type="entry name" value="ROK_glcA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00744">
        <property type="entry name" value="ROK_glcA_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01125">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH85531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="373" mass="40155" checksum="32E1B8FDB275CF54" modified="2015-07-22" version="1">MTAAERTPHGSTARATVLRSVSHRERRSHLTAPRVPTVGIDIGGTKVAAGVVDADGHILERATTETPDKSKSPKVVEDVIVELVLDLSERHDVHAVGIGAAGWIDADRSRVLFAPHLSWRNEPLRDALSERLRVPVMVDNDANAAAWAEWRFGAGRGEDYLVMITLGTGIGGAILEDGQVKRGKYGVAGEFGHMQVVPGGHRCPCGNRGCWEQYSSGNALVREARELAAAESPVAYGIIDRVKGNVGDITGPLITELAREGDAMCIELLQDIGQWLGVGIANLAAALDPSCFVIGGGVSSADDLLIKPAQDAFRRSLTGRGYRPEARIVRARLGNDAGLVGAADLARLVARRFRRTNRRRVERYERFAQVVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBN3</accession>
    <name>A0A0F7NBN3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zn-dependent hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_30900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019118.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_30900"/>
    <dbReference type="EnsemblBacteria" id="AKH85890">
        <property type="protein sequence ID" value="AKH85890"/>
        <property type="gene ID" value="AA958_30900"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_30900"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6530"/>
    <dbReference type="OrthoDB" id="767622at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="29"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="262" mass="26849" checksum="B8E6A808D7254ADF" modified="2015-07-22" version="1">MAETGTSAEQFPVRVLGGPTALFEYGGLRFLTDPTFDEPRVYEVPGGSLTKTAPPAAAPAALGRIDVVLLSHDEHPDNLDESGRALLADVPLTLTTPGGGKRLGAGARGLAGWETAELDRPGGGTVTVTAVPAVHGPEPRAVVEAAIGEVTGFVLTGAGLPVVYVSGDNASTAAVAETAGRFGPVDTAILFAGAPRVPVLFGGEPLVLDSAQAAEAARVLGARRVVPVHYDSWSHFTEGRTELAAAFDAAGLRDRLDWGLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBQ1</accession>
    <name>A0A0F7NBQ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_24685</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018125.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH84873">
        <property type="protein sequence ID" value="AKH84873"/>
        <property type="gene ID" value="AA958_24685"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_24685"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5206"/>
    <dbReference type="OrthoDB" id="1550716at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045776">
        <property type="entry name" value="DUF6202"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19705">
        <property type="entry name" value="DUF6202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH84873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="277" mass="30005" checksum="455CB01B0D8326FC" modified="2015-07-22" version="1">MTAAAELPAVDRNRLDDRVEEQIDKAQLRRTDNPFFAAARDAGSVTPEAGLDIAVWWRAMTKGFMFTTLAGLGVIARSFAADRDPSRTLLGALQTVYRVIGDDLDNAAPEFSSVAPRGPAGIHYVWWDDTITAPLAARVDESARARAQELPGPVAELLANMDRLADSPHGAAVQLRVVETIALDIAVAFRRMYGKVTAGGEKVFTEKEQFTWIDAHIKAETVHAAQVSDDETGMTTLVTDDAEAAEFLRLVEEYAGSFSRALQCFARRLAEPAAAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBV1</accession>
    <name>A0A0F7NBV1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Secreted/membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_24885</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018155.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_24885"/>
    <dbReference type="EnsemblBacteria" id="AKH84904">
        <property type="protein sequence ID" value="AKH84904"/>
        <property type="gene ID" value="AA958_24885"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_24885"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5246"/>
    <dbReference type="OrthoDB" id="2048416at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019675">
        <property type="entry name" value="DUF2550"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10739">
        <property type="entry name" value="DUF2550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH84904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="146" mass="16220" checksum="D28D7304AB952FCD" modified="2015-07-22" version="1">MILALLLAGAVVALLLLGLFLFGLRRRLIQRAGGTFDCSLRWSARADRPGKGWAYGVARYSGDVIEWFRVFSYAPRPRRVLRRDGIEVLERRAPAGEEELALLSDAVVLACRHDEDRIELAMSEDALTGFLAWLEAAPPGQRVNVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBW8</accession>
    <name>A0A0F7NBW8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_29595</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018930.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_29595"/>
    <dbReference type="EnsemblBacteria" id="AKH85701">
        <property type="protein sequence ID" value="AKH85701"/>
        <property type="gene ID" value="AA958_29595"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_29595"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6246"/>
    <dbReference type="OrthoDB" id="1571811at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH85701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="330" mass="36344" checksum="02E267E6A25AE55C" modified="2015-07-22" version="1">MHNMPYEPALPVGRGELSAATLAYLRGDSASLPHADGPARSDPYGDDLQLALYLCYELHYRGFAGVDDEMEWDAALLAFRRALEDRFLTALREDAPLPVDVGTALTALLVEPVKGDSVSHHLRDDGTMWQLREYAVQRSLYHLKEADPHAWVLPRLHGRAKAGMAAVEYDEFGAGRGERVHARLFADLMRDLSLDPGYGRYLDAACPQMLAVVNLMSLLGLHRSLRGALVGHFATVEITSSPSSRRLVQAIERLGAGPAAEHFHREHVEADAVHEQVVRHEVVAGLLEAEPQLAADVTFGIAATGLVEDRFTEHVLGSWRAERSSLRLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NC39</accession>
    <name>A0A0F7NC39_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">L-seryl-tRNA(Sec) selenium transferase</fullName>
            <ecNumber evidence="5">2.9.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Selenocysteine synthase</fullName>
            <shortName evidence="5">Sec synthase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Selenocysteinyl-tRNA(Sec) synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">selA</name>
        <name evidence="8" type="ORF">AA958_30005</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>H(+) + L-seryl-tRNA(Sec) + selenophosphate = L-selenocysteinyl-tRNA(Sec) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:22728"/>
            <dbReference type="Rhea" id="RHEA-COMP:9742"/>
            <dbReference type="Rhea" id="RHEA-COMP:9743"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16144"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:78533"/>
            <dbReference type="ChEBI" id="CHEBI:78573"/>
            <dbReference type="EC" id="2.9.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5 6">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Aminoacyl-tRNA biosynthesis; selenocysteinyl-tRNA(Sec) biosynthesis; selenocysteinyl-tRNA(Sec) from L-seryl-tRNA(Sec) (bacterial route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SelA family.</text>
    </comment>
    <dbReference type="EC" id="2.9.1.1" evidence="5"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018984.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_30005"/>
    <dbReference type="EnsemblBacteria" id="AKH85756">
        <property type="protein sequence ID" value="AKH85756"/>
        <property type="gene ID" value="AA958_30005"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_30005"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6335"/>
    <dbReference type="OrthoDB" id="1124266at2"/>
    <dbReference type="UniPathway" id="UPA00906">
        <property type="reaction ID" value="UER00896"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004125">
        <property type="term" value="F:L-seryl-tRNASec selenium transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001514">
        <property type="term" value="P:selenocysteine incorporation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097056">
        <property type="term" value="P:selenocysteinyl-tRNA(Sec) biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00423">
        <property type="entry name" value="SelA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018319">
        <property type="entry name" value="SelA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004534">
        <property type="entry name" value="SelA_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025862">
        <property type="entry name" value="SelA_trans_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12390">
        <property type="entry name" value="Se-cys_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03841">
        <property type="entry name" value="SelA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00474">
        <property type="entry name" value="selA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="5 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0711">Selenium</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Se-cys_synth_N" evidence="7">
        <location>
            <begin position="5"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="5 6">
        <location>
            <position position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR618319-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH85756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="436" mass="44508" checksum="B43202C8139C6633" modified="2015-07-22" version="1">MTDTRRRVPRTDALLADPRLADAARRLGRTLVRRAVAEAQHRVRNGGLAPEEAADAAVAALPRSATSLRPVVNATGVVVHTNLGRAPLSAAATEALRTASGPTDVEFDLGDGRRARRGRGALAALAEAVPHAEAVHLVNNNAAALVLAATALAGGREIVISRGELVEIGDGFRLPELLESTGARLVEVGTTNRTHFEDYARAVGPGTGLVLKVHPSNFLTTGFVSSVPVARLATLGVPLVHDIGSGLLRPHPALPDEPDAATSLDQGAGLVTASADKLLGGPQAGLLLGRRDLVERLRTHPLARALRVDKLTLAALEATVLGPQPPVARALAAREAELAARAGTLAAGLAERGVAAEAVPSEARVGGGGAPGVTLPSAAVALPAALAVPLRTGDPAVVGRVHGDRLLLDLRTVPEEDDATMLAAVLAAAAPPPEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCC4</accession>
    <name>A0A0F7NCC4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNA polymerase sigma factor SigD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_21505</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017609.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_21505"/>
    <dbReference type="EnsemblBacteria" id="AKH84347">
        <property type="protein sequence ID" value="AKH84347"/>
        <property type="gene ID" value="AA958_21505"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_21505"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4527"/>
    <dbReference type="OrthoDB" id="1914729at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="36"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="7">
        <location>
            <begin position="145"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="108"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH84347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="200" mass="21910" checksum="F540EF5A23D7AEE0" modified="2015-07-22" version="1">MRGNETTVSQTAERPVEIRGLVQLAAEGDERATHDLLAHVHPLALRYVRTRLHRLPGDARHFVDDLAQEVCIAVLCALPRYRDTGRPFEAFVFAIAAHKVADLQRAAMRGPGSTAVPSDEMPERPDDSLGPEEQALLSSDAEWAKQLLASLPANQRELLLLRVAAGFSAEETGQMLGMTPGAVRVAQHRALSRLRALARQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCC9</accession>
    <name>A0A0F7NCC9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">UDP-N-acetyl-D-glucosamine dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_21535</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017614.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_21535"/>
    <dbReference type="EnsemblBacteria" id="AKH84352">
        <property type="protein sequence ID" value="AKH84352"/>
        <property type="gene ID" value="AA958_21535"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_21535"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4534"/>
    <dbReference type="OrthoDB" id="295459at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017476">
        <property type="entry name" value="UDP-Glc/GDP-Man"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014027">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036220">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014026">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001732">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028359">
        <property type="entry name" value="UDP_ManNAc/GlcNAc_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00984">
        <property type="entry name" value="UDPG_MGDP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03720">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03721">
        <property type="entry name" value="UDPG_MGDP_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500136">
        <property type="entry name" value="UDP_ManNAc_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000124">
        <property type="entry name" value="UDPglc_GDPman_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00984">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52413">
        <property type="entry name" value="SSF52413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03026">
        <property type="entry name" value="NDP-sugDHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDPG_MGDP_dh_C" evidence="4">
        <location>
            <begin position="324"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH84352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="425" mass="44872" checksum="1CF129B43C4EAEEB" modified="2015-07-22" version="1">MPADVAVIGIGHHGLPLARAAAAAGFSVVGYDPDPRAAEALATGRPPVGGSLTAAEVRRLLTTGFRASADPADLGGVRTAVICVPTPLAEDGALDLGPVADAARELARHLKPRTTVLLESAAYPGSTENLLRPLLQQGSGLRAGRDFHLAYSPGPLDPADTASAPKVVGGLTPGCTEAAVAFYGRFAERVVRARGPREAETVRLLEGNVRHVNFALVNELTWFCHDRGIDLWDVVRCAETRPFGTAHSFRPGPGIGGHGVPVDPGRVPVPVPHPGGRTAPGFDHPLRMVDLAREVNGRMPRYVVQRCAQLLNEHGKSARGARVLLLGVTYEPDVADLERTPATDVAARLTELGARVGFHDPYVTAWQVLGRPVPRTGPVYDAAADADLTVLLQPHRTYDLQALAVKAQLLLDTRGATPPGAAHRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCK5</accession>
    <name>A0A0F7NCK5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AA958_22120</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017704.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_22120"/>
    <dbReference type="EnsemblBacteria" id="AKH84442">
        <property type="protein sequence ID" value="AKH84442"/>
        <property type="gene ID" value="AA958_22120"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_22120"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4659"/>
    <dbReference type="OrthoDB" id="1827824at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="9">
        <location>
            <begin position="222"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="289"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AKH84442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="515" mass="55682" checksum="AE5FFB47A7C9A523" modified="2015-07-22" version="1">MSPGPADAQGRQGLVRGWAAGLLRWISLRLRLVIVFALVALVSAVSVAGIAYWLNRDSVLTRTQDASLKDFRESLQDESGELDLRSGCTDLAKAARRLSSTTQNFDVILISGGGGSGGEPGCVERSDPSFTLHDVPETLKTAVDQRRDDGKWPYHLYWQRVTMDGTPYLVGGARVIGTDWTGYMFKSLDSERRDLNSLAWSLGIATGLSLIGSALLAQGAASTVLRPVQRLGDAARRLGEGKLDTRLRVTGTDELADLSRTFNQTAERLQQRVEELSEREKSSRRFVADMSHELRTPLTAMTAVSEVLEEEQENLDPMIAPAVQLVVQETRRLNDLVENLMEVTRFDAGTARLVLDDVDVADQVTACIDARAWLDAVELDADRGIVARLDPRRLDVILANLIGNALKHGGSPVRVSVRTTADAPGAGDLVIEVKDNGPGIPAEVLPHVFDRFYKADTARPRSDGSGLGLSIAVESARIHGGTITAANDPAGGAVFTLRLPRDSSAAAEALEQEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCM4</accession>
    <name>A0A0F7NCM4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Adenylate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_22235</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the adenylyl cyclase class-3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017723.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_22235"/>
    <dbReference type="EnsemblBacteria" id="AKH84462">
        <property type="protein sequence ID" value="AKH84462"/>
        <property type="gene ID" value="AA958_22235"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_22235"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4683"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009190">
        <property type="term" value="P:cyclic nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032026">
        <property type="entry name" value="Ad_Cy_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16701">
        <property type="entry name" value="Ad_Cy_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Guanylate cyclase" evidence="3">
        <location>
            <begin position="230"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="364"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH84462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="415" mass="43807" checksum="39BB95DF4C622856" modified="2015-07-22" version="1">MSEVAGSSGAEEPRDPAGPDGSEAASGASGTDGPAGAAGAAGGVPNAEGPEGSAAPEEPDERVDPESEDDPIAIRIEQLILGSDRRYTPFQAARAAGVPMELAARFWRAMGFADIGQAKALTEADVLALRRLAGLVEAGLLSEGMAVQVARSTGQTTARLADWQIDSFLEGLTEPQEGMSRTEIAYPLVELLLPELEEFLVYVWRRQLAAATGRVVQAQDDDEMVDRRLAVGFADLVGFTRLTRRLEEEELGELVEAFETTAADLVAAHGGRLIKTLGDEVLFSADDAGTAAEIGIRLIETLAHDETMPELRVGIAFGTVTTRMGDVFGTTVNLASRLTSIAPKDTVLVHGDFAEELIRDGAAPESEAAATAAEKAAAEGGTGEAPSYRFALQPMWQRPVRGLGVVEPWLLSRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCR7</accession>
    <name>A0A0F7NCR7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Endoribonuclease L-PSP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_33225</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019505.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86280">
        <property type="protein sequence ID" value="AKH86280"/>
        <property type="gene ID" value="AA958_33225"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_33225"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.7018"/>
    <dbReference type="OrthoDB" id="1850770at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="PTHR11803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="SSF55298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519306" evidence="2">
        <location>
            <begin position="32"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH86280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="166" mass="17728" checksum="1DA70B00827C51D0" modified="2015-07-22" version="1">MPSNRRDFIRKAAPVAAVAAVPVVAGGQAMADDKDQSSGKGHGRPPRKEVHYPGGGEPPENPLFSPIVTYGNMVFISGIGAHFEGDIRSHTDHVLNEIERYLESVGSSMEKVLKVNVYLNTLDDYAGMNEVFLGRWGKEPGVRTTIAAAAGIPGDSLVEIDCIAVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCZ3</accession>
    <name>A0A0F7NCZ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carnitine dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_32050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019314.1">
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_32050"/>
    <dbReference type="EnsemblBacteria" id="AKH86086">
        <property type="protein sequence ID" value="AKH86086"/>
        <property type="gene ID" value="AA958_32050"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_32050"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6767"/>
    <dbReference type="OrthoDB" id="969868at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="SSF89796"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="331"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="389" mass="40124" checksum="D5345020AC26C122" modified="2015-07-22" version="1">MGSTGHGPLHGVRVVELAGIGPGPFAAMLLADLGADVVRIDRPGGPGLGIDPAHDLTNRNKRSVVLDLKSASGAAAALALAERADILVEGFRPGVAERLGVGPGDCLARNPRLVYGRMTGWGQEGPLAETAGHDIGYVAVTGALGMIGPAGGPPAVPANLLGDYAGGSLYLVVGVLSALQHARTTGEGQVVDAAIVDGTAHLTAMIHAMVAAGAWTDRRGANLLDGGAPFYGVYETADGQYMAVGALEPAFYEEFVRLLGAPGHLPDRGDPAAWAELRERLAARFRERTRAEWTEVFAGSDACVAPVLSLREARDHPHLAARGTFTEEYGTVQPAPAPRFSATPGAVRRPPAAPGADTAAVAREWDVPGLSGLPDPTPTPTPAPTQEER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7ND22</accession>
    <name>A0A0F7ND22_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein tyrosine phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_32245</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019349.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_32245"/>
    <dbReference type="EnsemblBacteria" id="AKH86121">
        <property type="protein sequence ID" value="AKH86121"/>
        <property type="gene ID" value="AA958_32245"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_32245"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6808"/>
    <dbReference type="OrthoDB" id="1972497at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016311">
        <property type="term" value="P:dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026893">
        <property type="entry name" value="Tyr/Ser_Pase_IphP-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13350">
        <property type="entry name" value="Y_phosphatase3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="SSF52799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TYR_PHOSPHATASE_2" evidence="2">
        <location>
            <begin position="123"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH86121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="263" mass="28699" checksum="3D78204BFF86F08C" modified="2015-07-22" version="1">MTQTTEPELTGVRNFRDVGGLPTTGGGRTRTGRLYRSGHLAHATAEDTAFLGSLGLRTVYDFRNAADIRLDGPDVDLPGVRNVNVPLNDPAEGKEFWKLVRDGDIPTLRSLLGDGQAAARMEDSYRDMILHRNAEHSRVLHSLADDGAPALLHCAAGKDRAGLTIALALLAVGVEREAIEADYLESNAQHRRYRVQRGEGAQGGTSPEVMELLSPLFDARASYLGAAFATIAERWGTVDRYFHEALRLSHTTRDRLRASLLTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7ND73</accession>
    <name>A0A0F7ND73_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">LacI family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_33985</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019637.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_33985"/>
    <dbReference type="EnsemblBacteria" id="AKH86415">
        <property type="protein sequence ID" value="AKH86415"/>
        <property type="gene ID" value="AA958_33985"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_33985"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.7176"/>
    <dbReference type="OrthoDB" id="1796334at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="5">
        <location>
            <begin position="29"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH86415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="363" mass="37900" checksum="48A314E0D95492C4" modified="2015-07-22" version="1">MTHQHPEPGAAQTGAEPAAPAPPRRRSRPTIGDVAALARVSKATVSFVVNGRAGVSTHARQRVLEAAAELGWQPSAGARALSTRRAQALGLVIRRPPELLSTDPFFPQFVAGVESGLSPLDYALVLQVVETEEAEHNAYERLSHDGRADGVFLTDLQLGDRRPALTDRLGLAALIIGPDRPDSPVPAIGVDDAEGVRRAVGHLHALGHRRIGHVSGAEGYVHAEARRRAWATALADAGVPEGPLEAGDFTGAGGARATHALLDLPEPPTAILYANDLMAIAGIAAATGRGLSVPGDLSVVGFDDIPLAEYIAPPLSTVRQDVIAWGRAAARQLVSLTQGHPFQAPALPPVEFVARASTAPPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDS8</accession>
    <name>A0A0F7NDS8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADPH:quinone reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_28645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018787.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_28645"/>
    <dbReference type="EnsemblBacteria" id="AKH85553">
        <property type="protein sequence ID" value="AKH85553"/>
        <property type="gene ID" value="AA958_28645"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_28645"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6035"/>
    <dbReference type="OrthoDB" id="884088at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043880">
        <property type="term" value="F:crotonyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010085">
        <property type="entry name" value="Crot_CoA_red"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01751">
        <property type="entry name" value="crot-CoA-red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="49"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="472" mass="51836" checksum="3B8175E7C2754509" modified="2015-07-22" version="1">MNEILAAIQAPDSTAADFASLPLPESYRAVTVHKDETKMFEGLTTRQKDPRKSLHLDEVPVPELGPGEALVAVMASSVNYNSVWTSIFEPLSTFAFLERYGRLSPLARRHDLPYHVIGSDLAGVVLRTGPGVVAWRPGDEVVAHCLSVELESADGHDDTMLDPEQRIWGFETNFGGLAEIALVKSNQLMPKPDHLSWEEAAAPGLVNSTAYRQLVSRNGAAMKQGDNVLIWGASGGLGSYATQFALAGGATPICVVSSPEKAEICRRMGAEAIIDRRGEDYRFWRDEHEQDPREWKRFGARIRELTGGEDVDIVFEHPGRETFGASVYVTRRGGTIVTCASTSGFVHEYDNRYLWMSLKRIIGSHFANYREAWEANRLVDKGRIHPTLSRTYPLAETGQAAYDVHRNLHQGKVGVLCLAPAEGLGVRDEEKRAAHIDAINLFRGDPAPGRQPAAAPGRPGVRERAVEHAGNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDV8</accession>
    <name>A0A0F7NDV8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_10480</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019938.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_10480"/>
    <dbReference type="EnsemblBacteria" id="AKH86670">
        <property type="protein sequence ID" value="AKH86670"/>
        <property type="gene ID" value="AA958_10480"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_10480"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2208"/>
    <dbReference type="OrthoDB" id="817710at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="3"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="129"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="129"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH86670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="234" mass="25844" checksum="33C7899DEE84CFD8" modified="2015-07-22" version="1">MACVLLVEDDQFVRSALIRHLTDAAHTVRSVGTALEALREVAHHGFDVVILDLGLPDLDGAEALRMLRGLTDVPVIVATARDDESEIVRILNDGADDYLVKPFSVEHLQARLGAVLRRAGGRTAAAPPPRQLRVGGLAIDLRRRSAELDGRELDLTRREFDMLAFLAERPGVVVPRRELLSEVWRQSYGDDQTIDVHLSWLRRKLGETAARPRYLHTLRGVGVKLDPPAGIPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDW3</accession>
    <name>A0A0F7NDW3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_10675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019944.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_10675"/>
    <dbReference type="EnsemblBacteria" id="AKH86675">
        <property type="protein sequence ID" value="AKH86675"/>
        <property type="gene ID" value="AA958_10675"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_10675"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2245"/>
    <dbReference type="OrthoDB" id="1687355at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012551">
        <property type="entry name" value="DUF1707"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08044">
        <property type="entry name" value="DUF1707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="238" mass="26165" checksum="216F26CC3F57F9EC" modified="2015-07-22" version="1">MTSDEHLPELRASDADRERVADILRDALAEGRLAMDEFEERLEETYRAKTYAQLEPLTRDLPAAGAAPAAREAAPAARPAAGWAGRVGGEATSRRGIAIMSGFQRKGAWTVPRRFTMFSFWGGGELDLREADFEAAEVEIRCISIMGGAHVILPPDMALEVRGIGIMGGFDHSQTGVPHAPGAPRVTLTGFAFWGGVGTSRKKTKAARRAEAEAAREQRRLAREERRLAREERRKRLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NEH2</accession>
    <name>A0A0F7NEH2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_10905</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019950.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_10905"/>
    <dbReference type="EnsemblBacteria" id="AKH86681">
        <property type="protein sequence ID" value="AKH86681"/>
        <property type="gene ID" value="AA958_10905"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_10905"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2295"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="225"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="280"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="310"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="344"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="377"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="417"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="451"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="31"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH86681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="486" mass="49413" checksum="CA17C01AE4CC7DDB" modified="2015-07-22" version="1">MASLESRDTDVAPAGSPPAPEGVLRRPYRALSIGIVTVVLLIAFEATAVGTAMPVAAHDLDGIGLYAYAFSAFYTTALFAMVFSGQWCDSSGPLRPLTAGIGAFAAGLVISGTAQTMWAFVAGRAVQGLGGGLVIVALYVTVSRAYPERLRPSILAAFAASWVVPSVVGPLAAGGVTEHVGWRWVFLGIPPLVVVPLAVALPAIRRRARGPVDPAAPPALDRRRVRLALAIAAGGGLLQYAGQDLRWLSLLPALAGVALLVPAVRVLLPRGTYVAARGLPTVVLMRGIAAGSFIAAESFVPLMLVTQRGLSVTEAGMCLAVGGATWALGSWTQARPRLDPYRTQLVRIGMLLAATAIATAPLVLVESLPVWIVPVEWAFGCYGMGMVISGTSVLLLKLSAPEEAGTNSAALQLSDSLANVVLLAVAGVIFAALGGAAVGHGALGAGGDAHAGAFVAVLLPMAAVALVGAAVAGRLRTAPGAKTVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NEN6</accession>
    <name>A0A0F7NEN6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_26410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018417.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_26410"/>
    <dbReference type="EnsemblBacteria" id="AKH85177">
        <property type="protein sequence ID" value="AKH85177"/>
        <property type="gene ID" value="AA958_26410"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_26410"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5560"/>
    <dbReference type="OrthoDB" id="1750943at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="147" mass="16502" checksum="83D80DADDB812118" modified="2015-07-22" version="1">MRSKITYIVLSAVLVVYFFLAGTRGWYLLREGTPLTVAFGVAVLVLPAIGIWFLWHTTAFARAASALARELDAEGGLPVDELKRTPSGRIDRDSADAVFRRRKAETEAAPEDWRSWFRLAVAYHDARDTPRARKAMQQAIRLRRAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-08-12" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NEU3</accession>
    <name>A0A0F7NEU3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_22040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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    </dbReference>
    <dbReference type="RefSeq" id="WP_047020318.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86960">
        <property type="protein sequence ID" value="AKH86960"/>
        <property type="gene ID" value="AA958_22040"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_22040"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4642"/>
    <dbReference type="OrthoDB" id="2087633at2"/>
    <dbReference type="Proteomes" id="UP000034283">
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    </dbReference>
    <dbReference type="InterPro" id="IPR009956">
        <property type="entry name" value="Post-segregation_anti-tox_CcdA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07362">
        <property type="entry name" value="CcdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="78" mass="8480" checksum="D891FA4CBE3BC559" modified="2015-07-22" version="1">MTLSMIECMQTRERVTVTLPPDLLATAKAAAHGNLSAYVERAIRAQALREAADAVSRWRGDTSGDVEEITETFGEDIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NF38</accession>
    <name>A0A0F7NF38_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_31205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019171.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_31205"/>
    <dbReference type="EnsemblBacteria" id="AKH85943">
        <property type="protein sequence ID" value="AKH85943"/>
        <property type="gene ID" value="AA958_31205"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_31205"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6594"/>
    <dbReference type="OrthoDB" id="1809199at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="274"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="298"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="327"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="355"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="384" mass="39067" checksum="9CBC0476FB2F3C43" modified="2015-07-22" version="1">MPRIHDDFRRAQVAIAALFCFLGFQYVTWVSRLPRVKDELALTATELGLLLMACGAGAAASFPLVAHLMKAMGAKRLAFASAGALLLFLPAFAAAPTYPVALVLVAADGVAVGCLNVAMNAQGAALEEIHERTAMAKMHATFSAGSLAAALLASAVQTATEAMAAHFAVAAVLLLALLAVARTGLPAGNGFRQPEKGRRRWRLPSRVTLWMGCAMAFGTVTEGAMNDWSTLYLEDVADAAPEIAPLGIAVVSVMMVVARLFADGWRTRWGDGPVVTLGSVLAGTGLAVAVLAGGVVPALLGFACVGLGVAAVTPCVYVAAAREGPDALSLVASMGTTGLLGGPAAIGFIAGAAGLAWGMGAVAASALLVSVCTTRIRWPALSNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NF40</accession>
    <name>A0A0F7NF40_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase</fullName>
            <ecNumber evidence="6 7">6.3.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">D-alanyl-D-alanine-adding enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">murF</name>
        <name evidence="11" type="ORF">AA958_28385</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>ATP + D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine</text>
            <dbReference type="Rhea" id="RHEA:28374"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57822"/>
            <dbReference type="ChEBI" id="CHEBI:61386"/>
            <dbReference type="ChEBI" id="CHEBI:83905"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6 7">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MurCDEF family. MurF subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.10" evidence="6 7"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020480.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_28385"/>
    <dbReference type="EnsemblBacteria" id="AKH87085">
        <property type="protein sequence ID" value="AKH87085"/>
        <property type="gene ID" value="AA958_28385"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_28385"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5982"/>
    <dbReference type="OrthoDB" id="1861122at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047480">
        <property type="term" value="F:UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008766">
        <property type="term" value="F:UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02019">
        <property type="entry name" value="MurF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000713">
        <property type="entry name" value="Mur_ligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035911">
        <property type="entry name" value="MurE/MurF_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005863">
        <property type="entry name" value="UDP-N-AcMur_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01225">
        <property type="entry name" value="Mur_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="murF"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4 6 7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1 6 7" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 6 7" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5 6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 6 7" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="31"/>
            <end position="79"/>
        </location>
    </feature>
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        <location>
            <begin position="108"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_C" evidence="9">
        <location>
            <begin position="317"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="109"/>
            <end position="115"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AKH87085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="447" mass="44991" checksum="B6C4FD654C26A8BC" modified="2015-07-22" version="1">MVPLSLREIAAVVGGTVEGDGAVTVTAPAVLDGRQAEPGGLFVAVAGERVDGHDYAGQAGRAGVVAVLGSRPTPLPTVVVEDVQAALQRLAAHVVARLRRGLTVFGLTGSQGKTSTKDLVAAVLSGTAPTTATFGSFNNELGVPLTMLRADLGTRFLVLEMGARRIGDIAALTGLVAPDVAVVLNVGQAHLGEFGSRAAIATAKGELVRGLAPGGTAVLNADDPRVAAMRALTDGPVLTFGREEHADVRVLDLALDACGRPSFTLRTADASARVALPLVGAHQALNASAAAAAGLAAGIPLDVAAQGLATASLSKWRMELRDLAGGVTLLNDSYNANPDSTRAALDALSAIEGGRRIAVLGEMLELGEESRAAHRAVGAYAASRADLVLAVGEAARPIADGAGERAMALADNDAAVDWLRGNLAAGDVVLVKASRGAGLDEVAAALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NF53</accession>
    <name>A0A0F7NF53_9ACTN</name>
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        <submittedName>
            <fullName evidence="4">CBS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_29095</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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        </lineage>
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    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="3">
        <location>
            <begin position="82"/>
            <end position="138"/>
        </location>
    </feature>
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        <location>
            <begin position="135"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH87100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="208" mass="22657" checksum="566B10710C3211C4" modified="2015-07-22" version="1">MTRTVIAVGRDAPFKEIVTTLRQWKVSALPVLAGDGRVTGVVSEADLLPKEEFRDRDPTRFEQLRRLDDLARAGARTARELMSVPAVTVRADASLAEAARIMAVRHVKRLPVVDAEGKLAGVVSRADLLKVFLRSDEELAAAVRDEVLTHLFPGYPPPVEALVHEGVVSLTGQLSDRTRVPVLARLVRAVEGVVDVQMELAAPRPPVP</sequence>
</entry>
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    <accession>A0A0F7NFC4</accession>
    <name>A0A0F7NFC4_9ACTN</name>
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        <submittedName>
            <fullName evidence="2">Lipopolysaccharide kinase</fullName>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
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        <lineage>
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            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
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        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AKH86043">
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    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="DUF4032"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DUF4032" evidence="1">
        <location>
            <begin position="243"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="419" mass="46761" checksum="CA12B8E69BB7CE66" modified="2015-07-22" version="1">MEDERPRRTAVRPELQISATNPEHPAALLDLPWELPLDVWPEDCLVDLPRGISRHVVRFAEAGEEVVAIKEVPERAARREYELLRDLDRLGIPAVDALAVVTGRTGTDGEPLEPALVTRHLVGSRPYRAMFETTLRPGTVNRLMDALAVLLVRLHLAGFAWGDCSLSNTLFRRDAGAYAAYLVDAETGQIQPRLSNGQREYDIELARMNISGELMDLEASGALHPSIDPIPFGAAIAERYGDLWHELTRQSVYPADKRHYIERRIRRLHDLGFDVAEMQITHSPGGDTVSFVPKVVDAGHHQRQLLRLTGMDTEENQARRLLNDLESWMATQDDYAPGDPLGARPEVLAHRWVREVFRPTVGAVPLALRGQLDPAQVYHEVLEHRWLLAEQKQQDVGLEAAVADYVENVLPGSVAGTSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFC5</accession>
    <name>A0A0F7NFC5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Endoribonuclease L-PSP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_27730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_27730"/>
    <dbReference type="EnsemblBacteria" id="AKH85397">
        <property type="protein sequence ID" value="AKH85397"/>
        <property type="gene ID" value="AA958_27730"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_27730"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5844"/>
    <dbReference type="OrthoDB" id="1850770at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="PTHR11803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="SSF55298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519410" evidence="1">
        <location>
            <begin position="21"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="132" mass="13778" checksum="9676C39F25B552BC" modified="2015-07-22" version="1">MSVHRVNPASLARPSGFSHAVTATGSSLVFLAGQTALDGAGRVVGDTLPAQFEQALGNLLTALGACAGEPAHLTRVTVYATDPEDYRAHAAELGRIWRRLAGDTYPAMALIGVTRLWDAEALVELDGIAVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFQ4</accession>
    <name>A0A0F7NFQ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Dihydroorotase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_33220</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019504.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_33220"/>
    <dbReference type="EnsemblBacteria" id="AKH86279">
        <property type="protein sequence ID" value="AKH86279"/>
        <property type="gene ID" value="AA958_33220"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_33220"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.7017"/>
    <dbReference type="OrthoDB" id="1319925at2"/>
    <dbReference type="Proteomes" id="UP000034283">
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    </dbReference>
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        <property type="term" value="F:deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
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        <property type="entry name" value="Deacetylase_Atu3266-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
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        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42717">
        <property type="entry name" value="PTHR42717"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ADE_EF_0837"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519603" evidence="3">
        <location>
            <begin position="36"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="Amidohydro-rel" evidence="4">
        <location>
            <begin position="309"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="via carbamate group" evidence="1">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="2">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR039004-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR039004-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH86279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="445" mass="47164" checksum="8D68F3226D651EFB" modified="2015-07-22" version="1">MHVRSRVSWTVLPAALTLVLGASTVGATAPADAQAEGNDDKGAAYDLVIRRGHVIDPKNDIDGVRDVAVKDGKIAKVARSIDASGAEKTVDARGNYVTPGLIDMHAHMFPGPKQDYANGWNGVAPDGFTLRAGVTTAVDTGSAGASNFDQFKTEVIDKSKTRVLSFLNIVGKGMAGHPYEQDLADMKPGPAAEVAKANPETIVGIKTAHYNGPEWDPVENSVAAGEEAGVPVMVDFGANTPERPLSQLLNEKLRPGDVYSHMFSGLRGELGKDGKLNPAMQQGRDRGVVFEVGHGGGSFSWDVAVPGMKEGFTPDVISTDLHISSMNSGMKDMSNVMSKFLTLGMPLGDVVEASTWTPAQTIQRPDLGNLSVGAPADIAVFALEKGTFGYVDSFGWRIDGKEKLVAETTFRAGQAVWDLNGKAANEWYPGANPPKASAAEDHEHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-12-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFR3</accession>
    <name>A0A0F7NFR3_9ACTN</name>
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        <submittedName>
            <fullName evidence="9">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AA958_32500</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86158">
        <property type="protein sequence ID" value="AKH86158"/>
        <property type="gene ID" value="AA958_32500"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_32500"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6859"/>
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    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004869">
        <property type="entry name" value="MMPL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03176">
        <property type="entry name" value="MMPL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="207"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="538"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="565"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="597"/>
        </location>
    </feature>
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        <location>
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            <end position="640"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="678"/>
        </location>
    </feature>
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        <location>
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            <end position="339"/>
        </location>
    </feature>
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        <location>
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            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
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            <begin position="104"/>
            <end position="128"/>
        </location>
    </feature>
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        <location>
            <begin position="690"/>
            <end position="712"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH86158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="712" mass="74806" checksum="3B9179489BD1CA68" modified="2015-07-22" version="1">MAVNAAPSGEAPPGRWVPWLVIGLWVALAVVMVPLSGKLSSVTTDSAVDTLPASAESTKVAALDDSLPGGDSDTFVFVYHRAGGMTDADRATVERHYNTLAKRYPPKATAAAGEDDEGSPTSPSTDGKAMMFSLEVSTTYGPPEDVVGPLRDAAKDRPSGLELDVTGPGAIDGDMEAVFDGIDLQVLLTTIVVVTLLLILTYRSPVLWLIPLVAVGAAALTAMATVYLLVKGFGIVVNDQNSALLTILVFGVGTDYALLLIARYREALHHHENVRVAMVHALRGAAPAIVASAATVVAGLLCLLVADLNSTSGLGPIGAAGILCALVAMLTLFPAVLVVLGRRIFWPAIPRFSTAVEEKPGLWGRLGTAISRRRWVATLGSLGVLGVLALGLAGNTGALREQDQFLSAPDSVTGFTVLRQHFPELGGQPMTIFTRPAQQERVLDIVKDTRGVALAIPEQTSKGWANISAFPKDAPDTAAEYDTIKRVRTAVHAVSGAEAIVGGPSAENLDTEVTTKRDEKLVIPLVLAVVLIILGLLLRAILAPLVLMATVIVSFAAAFGGSVFVFDTILGFKGVDYSVPLLAFLFLVALGVDYNIFLASRAREETVRLGTRAGMLKALSATGGVITSAGLVLAATFAVLTSLPLVMLIEVGFLVTFGVLLDALLVRSVLVPALTLLVGRRIWWPSRLSRPAAEPPDGQQSLADDKEPALQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFU4</accession>
    <name>A0A0F7NFU4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_28915</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018835.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_28915"/>
    <dbReference type="EnsemblBacteria" id="AKH85602">
        <property type="protein sequence ID" value="AKH85602"/>
        <property type="gene ID" value="AA958_28915"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_28915"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6092"/>
    <dbReference type="OrthoDB" id="191097at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH85602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="459" mass="50510" checksum="4DECDDBC5894DCBA" modified="2015-07-22" version="1">MTPPKRLVVVDVVGLTPRLLDHMPNLRALADAGSKSALTPPLPAVTCTVQSTILTGAPPAEHGIVANGWYFRELGEVFLWRQHNALVGGDKLWEAARRAYPGYTVANVGWWYAMGMDTDYIVTPRPIYYADGRKEPDCYTRPPELHDELTAAFGTFPLFNYWGPTASIVSSQWIIDASRHILDAYSPDLTLVYLPHLDYDLQRYGPDDPRSHAAARELDDALAPLLADARAADAETVVLSEYGITQATTPVDVNRALRKAGLLEVYTQDGMEYLDPWASRAFAVSDHQIAHVYVRDPADVEATREILTKLPGVADVLSDSGKKAHGLDHPRAGELVAVAEPDAWFTYYYWLDDARAPDFAQLVEIHRKPGYDPAELFMDPTDPYVRLRAVSAIARKKAGMRYRLAVVPLDPAPVRGTHGRLPDDERDGPVLLTTRPGATSGPVPATDVKSLLLSLAGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFW2</accession>
    <name>A0A0F7NFW2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_32810</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May play a structural or regulatory role in gas vesicle synthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Vacuole</location>
            <location evidence="2">Gas vesicle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Vesicle</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019435.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_32810"/>
    <dbReference type="EnsemblBacteria" id="AKH86208">
        <property type="protein sequence ID" value="AKH86208"/>
        <property type="gene ID" value="AA958_32810"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_32810"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6932"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031411">
        <property type="term" value="C:gas vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031412">
        <property type="term" value="P:gas vesicle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009430">
        <property type="entry name" value="Gas-vesicle_GvpL/GvpF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36852">
        <property type="entry name" value="PTHR36852"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06386">
        <property type="entry name" value="GvpL_GvpF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0304">Gas vesicle</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="156"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH86208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="278" mass="29743" checksum="7FAD1DDB723576D8" modified="2015-07-22" version="1">MTGTVRGAAQPDAPASTATYVYAVCRGGDESALAGLPGQAPGAPVRLLRFGDLAAVVQDVPAAEFGEDALRERLTDRTELERCARAHHAVVAAAATAAPVLPLPLATIYRGDARASAALGADRDRFTAALRRIAGRAEWGVKVYARPAGSHTAPAAHTPERRDDGRTAARPGHAYLDRLRGARHERERRQEAGLQAVEEVDRVFADLAVAGRRLRPHDTGHTPGRGVHLLNGAYLVDEARAAEVADAVRRLRQRPECRDVEIELTGPWVPYSFAEAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NGL3</accession>
    <name>A0A0F7NGL3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidoglycan glycosyltransferase</fullName>
            <ecNumber evidence="2">2.4.1.129</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AA958_06535</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>[GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23708"/>
            <dbReference type="Rhea" id="RHEA-COMP:9602"/>
            <dbReference type="Rhea" id="RHEA-COMP:9603"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:78435"/>
            <dbReference type="EC" id="2.4.1.129"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.4.1.129" evidence="2"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019826.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_06535"/>
    <dbReference type="EnsemblBacteria" id="AKH86579">
        <property type="protein sequence ID" value="AKH86579"/>
        <property type="gene ID" value="AA958_06535"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_06535"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1364"/>
    <dbReference type="OrthoDB" id="1133883at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018365">
        <property type="entry name" value="Cell_cycle_FtsW-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013437">
        <property type="entry name" value="FtsW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001182">
        <property type="entry name" value="FtsW/RodA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30474">
        <property type="entry name" value="PTHR30474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01098">
        <property type="entry name" value="FTSW_RODA_SPOVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02614">
        <property type="entry name" value="ftsW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00428">
        <property type="entry name" value="FTSW_RODA_SPOVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="10" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0133">Cell shape</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="156"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="193"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="270"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="309"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="345"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AKH86579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="408" mass="43243" checksum="8A4BBD86940AE140" modified="2015-07-22" version="1">MRRAWDRPLTAYYLLLGGSLLITVLGLVMVFSASQIEALNSGLASTYYFRKQLVAATLGTILLLVAARMPIRLHRALAYPVLAMSLFLMALVQVPGIGQSVNGNTNWLNFGGPFQLQPSEFGKLALVMWGADLLARKQDKKLLTQWKHMLVPLAPVAMVLLGLIMLGGDMGTAMILGAILLGLLWVAGAPTRLFATVIAVGATLTVVLFTSSPHRMDRLRCIGATEPGPGDVCWQGLHGIYALASGGWFGSGLGASMEKWGELPEPHTDFIFAVTGEELGLAGTLSVLALFAALGYAGIRVAGRTEDAFVRYAAGGVTAWIMAQVVINIGAVLGLLPIAGVPLPLFSYGGSALLPAMFAVGLLIAFAREEPAARAALAMRPAGVLQSARRVLAGKRPESTARRARKTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NGN5</accession>
    <name>A0A0F7NGN5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF2087 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_07900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86599">
        <property type="protein sequence ID" value="AKH86599"/>
        <property type="gene ID" value="AA958_07900"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_07900"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1663"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018656">
        <property type="entry name" value="DUF2087"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09860">
        <property type="entry name" value="DUF2087"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2087" evidence="2">
        <location>
            <begin position="137"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH86599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="206" mass="21362" checksum="C943758365C01F18" modified="2015-07-22" version="1">MERSMNAASNAAASDAASAEDSSAEDSSADASAPAGHPPSCRDLVGLLAQTDRRAAYAALALGATSVTDVATRTGLRPPAAAAALQKLTAGGIAAFDAATRAYTLRDDAFRLAVQAEVRLTGRGGGDGAGGYFRRGRLTSIPGNAEVRSRVLAVVKDSFEPGTTYSEAKVNAICGEWLDDWVTLRRALVDEGLLRRNESGTAYERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NGZ8</accession>
    <name>A0A0F7NGZ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_31585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019235.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_31585"/>
    <dbReference type="EnsemblBacteria" id="AKH86007">
        <property type="protein sequence ID" value="AKH86007"/>
        <property type="gene ID" value="AA958_31585"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_31585"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6671"/>
    <dbReference type="OrthoDB" id="1367386at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="27"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="300" mass="31648" checksum="FF6951D6A7A1B9C0" modified="2015-07-22" version="1">MTHSPTAPVPGAAGPTFDIGGDMPVGRIGYGTMRLTDHPGIPPSEAVIWEPPRDRAGAVAVLRRAVELGVGLVDTADSYGLGAVEEVVAEALHPYPAGVVVATKAGLARPGPGQWVPLGRPAYLRQQAELSLRRLRTDRIDLFQLHRVDADVPLADQVGTLKELQDEGKVRHIGLSEVDVPQLRAAREIAAITSVQNLYNLAMRQHEAVVDYTAAEGIAFVPYFPMAVGTLAAPGGPVAQVAAELGATPAQTALAWLLRRAPNVLPIPGTTSLDHLAENVAARHLVLSDEQFARLSALGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NHB1</accession>
    <name>A0A0F7NHB1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_10770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019947.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_10770"/>
    <dbReference type="EnsemblBacteria" id="AKH86678">
        <property type="protein sequence ID" value="AKH86678"/>
        <property type="gene ID" value="AA958_10770"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_10770"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2265"/>
    <dbReference type="OrthoDB" id="461923at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012300">
        <property type="entry name" value="Pept_M6_InhA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008757">
        <property type="entry name" value="Peptidase_M6-like_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05547">
        <property type="entry name" value="Peptidase_M6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007519">
        <property type="entry name" value="Protease_InhA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03296">
        <property type="entry name" value="M6dom_TIGR03296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M6" evidence="1">
        <location>
            <begin position="26"/>
            <end position="718"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="727" mass="79336" checksum="BBD0477C5BC0E53D" modified="2015-07-22" version="1">MLSGETEAQPRAERDGSTVVKLDDGKYAELGRGAKTDKIFTVLVEFGDDVDDETMYDPDGPEGPKPPVVKYGGDAGPAHNQIAEPDRAVDNSTDWKADYDRQHYQDLYFSKDADKQSVAKYYEKQSSGKYTVDGEVSDWVSVKWNEARYGSNYCGDSTCASVWDLVRDATAKWAEDQKAAGRTDAEIKAQLAEYDVWDRYDFDGDGNFDEPDGYIDHFQLVHAGEDESAGGGAQGEDAIWAHRWYAYGTDAGSTGPGENKAGGTQIGDTGVWVGDYTVQPENGGLGVFAHEYGHDLGLPDLYDTAGGENSTAFWSLMSSGSWLGRGKDAIGDLPGDMTAWDKLQLGWLDYDTAKAATRSQHTLGRAEEQVEGKPQALVVELPEKAVTTTITKPAEGSKQWWSGMGDDLSNSLTRTVDLTGKSSASLSLAGWWDIEENYDYLYAEVSTDGGAGFTPLDGTADGAQIPRDGGDRPALTGVSGEYRDLEYSLDAYAGQEIQLRFRYQTDGGVAQKGFAADALTITADGAEVFADGAEGDDAGWTADGFSRVEESFTKDYPQYYIAENRQYVSYDKTLKSGPYNFGWVTDKPDWVEHFPYQNGLAVWLWDTSQLDNNTSEHPGAGLVLPVDAHPKPAKWADGSVMRNRIQAYDATFSTQPTDGFTLHKDGKPAKITSKKGVPVFDDRKGSYWDERNPGGSVKVPDTNTKITIVQEPSHGRTMTIQVAPSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NHB5</accession>
    <name>A0A0F7NHB5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Alpha-galactosidase</fullName>
            <ecNumber evidence="2 5">3.2.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AA958_32250</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
            <dbReference type="EC" id="3.2.1.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the glycosyl hydrolase.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.22" evidence="2 5"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019350.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_32250"/>
    <dbReference type="EnsemblBacteria" id="AKH86122">
        <property type="protein sequence ID" value="AKH86122"/>
        <property type="gene ID" value="AA958_32250"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_32250"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6809"/>
    <dbReference type="OrthoDB" id="131906at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052692">
        <property type="term" value="F:raffinose alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14791">
        <property type="entry name" value="GH36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038417">
        <property type="entry name" value="Alpga-gal_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002252">
        <property type="entry name" value="Glyco_hydro_36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031705">
        <property type="entry name" value="Glyco_hydro_36_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031704">
        <property type="entry name" value="Glyco_hydro_36_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16874">
        <property type="entry name" value="Glyco_hydro_36C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16875">
        <property type="entry name" value="Glyco_hydro_36N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005536">
        <property type="entry name" value="Agal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00743">
        <property type="entry name" value="GLHYDRLASE36"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_36N" evidence="9">
        <location>
            <begin position="29"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_36C" evidence="8">
        <location>
            <begin position="621"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="344"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="454"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="456"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="519"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="421"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="497"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="519"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR005536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR005536-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR005536-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AKH86122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="705" mass="78076" checksum="93863943120EB31B" modified="2015-07-22" version="1">MVEVGGNGRLWLLSGPHSSYALRLNRRDELLHLHWGPRLTLADAEALAAEPAPRFRSFESRLDGREEYPVEGGPRFVRPALAVRAADGGGGRGSEWQFRGAETESGVLRLTFHDPVHRLAVTLHYRMRAGADVLERWATAVHEGGPGDSALELLRLDSAAWTLPRADRRRLSHLHGRWAAESLLARAELTPGETVIGSRRGHTSHRHLPWIALDDGTAGEEHGEVYGCALAWSGSWRIAVQQLDDGVVQAVGGAGHDDSGLVLLAPGESYTAPVFAGLYTDGGFGAASRAWHAWQLAHVVPDAHIPRPVLYNSWEATKFDVELEHQRELARRAAAMGVELFVVDDGWFGSRTHAKAGLGDWTPNPDRFPDGLKPLADEVHALGMHFGIWVEPEMVNPDSDLYRAHPDWVHHRPGRRRTEFRHQLVLDLGRPEVRTYLWEQLDELLRSAPIDYVKWDFNRSLTEPGAHADPSVPHVRGLYDLLDRLRAAHPHVAFESCSGGGGRIDLGILSRTDQVWTSDNTDPLDRLPIQHGIGQIHPARVTAAWVTDSPNEQMQDRVSSLRYRFVSAMAGVLGVGGDLARWSGEELAEAGRWVELYKRIRPAVQLGRLYRLREPQEGLSAVQYVLGDDPERADEVVVLAWLQSQRYNESLPPLRLAAVDPAAEYEVLAGGEPGEVLRGGVLAHRGLHTGLHGDLDAAVVHLRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NHC6</accession>
    <name>A0A0F7NHC6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ferritin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_32355</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the Dps family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019364.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_32355"/>
    <dbReference type="EnsemblBacteria" id="AKH86137">
        <property type="protein sequence ID" value="AKH86137"/>
        <property type="gene ID" value="AA958_32355"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_32355"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6830"/>
    <dbReference type="OrthoDB" id="1742631at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016722">
        <property type="term" value="F:oxidoreductase activity, acting on metal ions"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01043">
        <property type="entry name" value="DPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002177">
        <property type="entry name" value="DPS_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023188">
        <property type="entry name" value="DPS_DNA-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008331">
        <property type="entry name" value="Ferritin_DPS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42932">
        <property type="entry name" value="PTHR42932"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00210">
        <property type="entry name" value="Ferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005900">
        <property type="entry name" value="Dps"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01346">
        <property type="entry name" value="HELNAPAPROT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00818">
        <property type="entry name" value="DPS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ferritin" evidence="3">
        <location>
            <begin position="15"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH86137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="154" mass="16881" checksum="3FFF2C48BE4061DC" modified="2015-07-22" version="1">MTTILDKKALDVTGEALQGALVDLLDLSLQGKQAHWNLTGPLFRELHLQLDKMVKLARGHADTLAERAAALGVSPDGRAKTIAANSPLPDIGPGKISDQKVIDDVTDMLEKASARMRQRVADTDDTDLITQDLLITATQDLEQQAWFFRSHRIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NHE9</accession>
    <name>A0A0F7NHE9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_17530</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_17530"/>
    <dbReference type="EnsemblBacteria" id="AKH86849">
        <property type="protein sequence ID" value="AKH86849"/>
        <property type="gene ID" value="AA958_17530"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_17530"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3689"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="58"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="170"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="59"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH86849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="275" mass="28546" checksum="952FD0F681705729" modified="2015-07-22" version="1">MGRSAGYAVLAVWVAAPVLPLLLWAFTGRWVYPALLPQDFSTRAWARVADPQQQVLDALGTSLALASCTAVVGTTLGALAARGLVLYAPPAAGLLRVLLLAPVLVPPFALAVGVQEMFVRAGLADHAVGVALVHLVPALPYTVLVMTGAHATYDIRMEHAARTLGASRTAVLRNVTLPLLAPALLAAATLAFLVSWSEYLMTVLVGGGLVTTLPLLLFSTAAGSGNQPLTAVLGILIAVPPVLLFGLAAALLRRRRAPWADPTPPSPRTERAAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NHS1</accession>
    <name>A0A0F7NHS1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_33350</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nicotinamide ribonucleoside (NR) uptake permease (TC 4.B.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019527.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_33350"/>
    <dbReference type="EnsemblBacteria" id="AKH86302">
        <property type="protein sequence ID" value="AKH86302"/>
        <property type="gene ID" value="AA958_33350"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_33350"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.7043"/>
    <dbReference type="OrthoDB" id="1301128at2"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:nicotinamide riboside transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="NMN_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH86302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="221" mass="23401" checksum="A5BC2A278BF28E24" modified="2015-07-22" version="1">MSALDSLNGVAFSVFGEDIKWADMTGNVLGLGALALGWRRSVAVWPAQLLSGAVLVVAYASAGLTGGVGKQLLVVGVSVWGWAQWTRGRRESGAIRVRFATWTERAWLVAATAAGTTAVALLFLAVPSLSWNPWPDAYLFTGSVAAMVAMARGWVEFWFAWLAVDAVGVPLAYSSDLKFSALVYVVYGVVVLLGLRAWWTASRRTAPPAAGRPEALEGAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NHY0</accession>
    <name>A0A0F7NHY0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_27750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020464.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_27750"/>
    <dbReference type="EnsemblBacteria" id="AKH87069">
        <property type="protein sequence ID" value="AKH87069"/>
        <property type="gene ID" value="AA958_27750"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_27750"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5848"/>
    <dbReference type="OrthoDB" id="1186918at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006764">
        <property type="entry name" value="SAM_dep_MeTrfase_SAV2177_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04672">
        <property type="entry name" value="Methyltransf_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017393">
        <property type="entry name" value="MTase_SAV2177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH87069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="274" mass="30088" checksum="7052BF0EEF62A590" modified="2015-07-22" version="1">MNPLSRDGEPEIDLHTDRPHSARVYDYLLGGKDNFAPDRAAGDASVRAWPSLPTSMKQTRVFMHRVTRTLARDYGVRQFLDVGTGIPTPPNLHEVAQEVAPECRVVYVDNDPIVLAHARALLQSSEEGRTGYIQADLRDPESILGDPQLRTVLDLDKPVALSLIAIVHFILDEDDPQGIVARLLDALAPGSFLALTVFTGDTDPERVAGVGREYNERGIPLQIRDRAEAERFFAGLEPIDPGVTLVHHWRPDGIGESVPNSHIAMYGGVARKPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NI09</accession>
    <name>A0A0F7NI09_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptide ABC transporter ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_33915</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019624.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_33915"/>
    <dbReference type="EnsemblBacteria" id="AKH86402">
        <property type="protein sequence ID" value="AKH86402"/>
        <property type="gene ID" value="AA958_33915"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_33915"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.7161"/>
    <dbReference type="OrthoDB" id="1303270at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="10"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="46"/>
            <end position="53"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH86402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="372" mass="38941" checksum="C01FC3D1A943FABB" modified="2015-07-22" version="1">MAPEPDPPLLDIIDLKTHFDTEEGTVRAVDGVSFTVPRGRIVCVVGESGCGKSVTARSVLGLVEEPGRIVGGSIRFYAPAAADAGAPADGAAAEDTADTAQARSLDLAALDPRGEEIRAVRGGRIAMVFQEPMAALSPMYTVGDQLVEAIRLHLPLSREAARTRAVQLLERVGIPGAERRMDAYSFQLSGGMCQRVMIAIALSCDPELLIADEPTTALDVTTQARILDLLTGIQADTGMSVLFITHDLGVVAEIADEVVVMYLGTVVEQGPVDAIFHDPAHPYTRALLGSVPRVGAGARQRLASIRGNVPHPSERPAGCPFHPRCASAVAGVCDTAEPPETALSEDRRVRCVLHGDAPPAVPAAATSEGATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NI36</accession>
    <name>A0A0F7NI36_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ArsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_29445</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_29445"/>
    <dbReference type="EnsemblBacteria" id="AKH87114">
        <property type="protein sequence ID" value="AKH87114"/>
        <property type="gene ID" value="AA958_29445"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_29445"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6213"/>
    <dbReference type="OrthoDB" id="1772343at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="2">
        <location>
            <begin position="17"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH87114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="133" mass="14425" checksum="9E8894F1AA989CDE" modified="2015-07-22" version="1">MGRELDIELWDVSTLPTASERARRLAPLLKALADENRLTLMLLLAERARSVRELTDASGMSQTLVSHHLTPLREQGLVLATPKGRSNIYSLCCDALVQPVQLLATLASLSPQSTECSSTAPGNENCSQPESAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NIK6</accession>
    <name>A0A0F7NIK6_9ACTN</name>
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        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_29175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
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        <lineage>
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        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_29175"/>
    <dbReference type="EnsemblBacteria" id="AKH87103">
        <property type="protein sequence ID" value="AKH87103"/>
        <property type="gene ID" value="AA958_29175"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_29175"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6151"/>
    <dbReference type="Proteomes" id="UP000034283">
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    </dbReference>
    <dbReference type="GO" id="GO:0003700">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR023187">
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    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
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    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01117">
        <property type="entry name" value="HTH_MARR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="5"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH87103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="141" mass="15905" checksum="AB2B8BAE807B5FFC" modified="2015-07-22" version="1">MRGLHTDTGYLLYRLGLRSGRLFNATLEESGLRLRHYALLRYLASAEGALQRELSERLGYDPSAIVNLVDDLERLGLVVRRPSPDDRRSRIVVLTDRGRDTLRDTDKGGRRVTDELLAPLHPDERAALHALLLRIAEPGPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NIM0</accession>
    <name>A0A0F7NIM0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">APH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_08755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
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            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_08755"/>
    <dbReference type="EnsemblBacteria" id="AKH86622">
        <property type="protein sequence ID" value="AKH86622"/>
        <property type="gene ID" value="AA958_08755"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_08755"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1847"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="64"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="342" mass="37034" checksum="60350E56E8543AE0" modified="2015-07-22" version="1">MVDACLAKLGMSALVPESVAAHPGRHDKCSGMTSEGRGVFVKRETVPGLARVRALENLHLPGVHRPALLGVDEEERLVVHELLAPAVSADELVRKGRFGPASAREVGEAIGALHRAQPPEPKEDASLDPETLVLPPTEQLEAIPLSWYTGASGAEIQLWRLLQRDAGLCDAVRALRRREREVRCVPAHCDVRLDQFLFVDGAAYLVDWEEFRVADAARDIGALLGEWLFEAMATAYRPARAGERPAGGPAQVAAELGSVQPVMTAFWLGYCSVRAPDDPGLPQRAASFAGWHLLDRLLTHGAGMVRLGAFHHAVFGLARTALLAPADLARLTRTERFDDARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NJK3</accession>
    <name>A0A0F7NJK3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_22115</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_22115"/>
    <dbReference type="EnsemblBacteria" id="AKH86962">
        <property type="protein sequence ID" value="AKH86962"/>
        <property type="gene ID" value="AA958_22115"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_22115"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4658"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002520165" evidence="2">
        <location>
            <begin position="28"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH86962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="184" mass="18457" checksum="DD9E585A7E31429A" modified="2015-07-22" version="1">MAAVAAVAVAVLATGCGIRPTSVPVDAGSAPSRAECAPGGPSPAARSADGETVRAVYLVCGTRLAPVPRSIPDGLAGTELAARLLAELEREPDEDEEDAGYSTAVSGLRVVDGQSGDPAGTVRLSRDPQGLGSPMLAQLVCTYAAGEERSAVLAGPDAGDPPYTFRCTDDALRAPENTVGEPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MXK0</accession>
    <name>A0A0F7MXK0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase type 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_00945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH80970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014336.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_00945"/>
    <dbReference type="EnsemblBacteria" id="AKH80970">
        <property type="protein sequence ID" value="AKH80970"/>
        <property type="gene ID" value="AA958_00945"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_00945"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.209"/>
    <dbReference type="OrthoDB" id="1865374at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="51"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH80970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="220" mass="23534" checksum="98C7D212218784E5" modified="2015-07-22" version="1">MPSPTRAAQDAVYHPYFARFYARLSVAAEQHGGVAEVRKELLTGLSGRVVEIGAGNGLNFAHYPPAVSEVVAIEPERHLRRLAAEAALRADVRVDVLPGTAEELPVESGSCDAAVASLVLCSVADVPRSLGELRRVLRPGGELRFYEHGRAGGRVMRAVQRAADRTVWPLLLGGCHSGRDVLGELTAAGFTLGPYRRVRMPEKGPPTPASYHVLGTALRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MXK4</accession>
    <name>A0A0F7MXK4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AA958_00970</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH80975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014341.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH80975">
        <property type="protein sequence ID" value="AKH80975"/>
        <property type="gene ID" value="AA958_00970"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_00970"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.215"/>
    <dbReference type="OrthoDB" id="1155802at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04590">
        <property type="entry name" value="CBS_pair_CorC_HlyC_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044751">
        <property type="entry name" value="Ion_transp-like_CBS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="DUF21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0129">CBS domain</keyword>
    <keyword evidence="5 7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="48"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="10">
        <location>
            <begin position="1"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="9">
        <location>
            <begin position="220"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="9">
        <location>
            <begin position="282"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AKH80975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="337" mass="36262" checksum="70E82CA5EE54BA29" modified="2015-07-22" version="1">MTVVQLIIGLLTLVFNAFFVGAEFALISVRRSQIEPYAQEGDRRARRVIWGLEHVSTLMAAAQLGITLCTLVLGVVAEPAIAHLLEPVFNAMGVPHGLVHPISFAIALAVATYLHMLLGEMVPKNVALADPVRSALLLGPPLVALTRALRPVVFTVNAFANALLRLLRVQTRDEVAASFSDADLARMVADSAEAALLDDRSAERLRDTLELGRRPVGDVVVPTGHVVTAPVGVTPEALEALSVASGFSRFPVVDDSGRILGYLHVKDALGTADREEPFPRTSMRRIARVRASAPLDDVLTAMRRSRTHLAAVTGEEGRVTGLVTMEDVLRELVGRES</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MY31</accession>
    <name>A0A0F7MY31_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Threonine aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_02040</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014514.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_02040"/>
    <dbReference type="EnsemblBacteria" id="AKH81150">
        <property type="protein sequence ID" value="AKH81150"/>
        <property type="gene ID" value="AA958_02040"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_02040"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.440"/>
    <dbReference type="OrthoDB" id="1124266at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001597">
        <property type="entry name" value="ArAA_b-elim_lyase/Thr_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01212">
        <property type="entry name" value="Beta_elim_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta_elim_lyase" evidence="4">
        <location>
            <begin position="28"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH81150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="366" mass="39761" checksum="76745829375656BE" modified="2015-07-22" version="1">MTTTTTGAAGQAPRTDAKRRHDPAVRGFASDNYAGAHPEILAALALANGGHQVSYGEDDYTAHLQHVFRGHFGMDADVYPVFNGTGANVVALQAVTDRWGAVICADTAHIHVDECGAPERVGGLKLLTVPTPDGKLTPELIDREARGWDDEHRAMPQVVSITQATEYGTVYTPDEIRAVCDHAHRRGMRVHLDGARIANAAASLDVPMRAFTNVAGVDILSFGGTKNGMLLGEAVVVLDPGAVRAMKHLRKLSMQLASKMRFVSAQFEALLAKDLWLRNARHANAMAARLADGVRGIDGVEVLHPVQANGVFARLPHDVSLALQKDFRFYFWDEADGVVRWMCSFDTAEEDVDTFVAAIAEEMRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MYA1</accession>
    <name>A0A0F7MYA1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_02350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014569.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_02350"/>
    <dbReference type="EnsemblBacteria" id="AKH81205">
        <property type="protein sequence ID" value="AKH81205"/>
        <property type="gene ID" value="AA958_02350"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_02350"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.504"/>
    <dbReference type="OrthoDB" id="1583550at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045652">
        <property type="entry name" value="DUF6397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19934">
        <property type="entry name" value="DUF6397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="334" mass="35388" checksum="76E6C6F3E4B912C3" modified="2015-07-22" version="1">MVVRTGAGAGARTAGAAGERAELLTFGRAAAELGLLPRELELAVQLGLVPTEPPQRAGGRRRVARAEVARLRAEDGTGGAGGAGAAAALRERLRLVGTVAGAEELGISSVRFTRLARAGCFAPARFYVNRYRVVVWLYLATEVERFGEREPGLLRGPLPPAMRAELAEGADARARGWRQRRVEQLLSERVDPWERAGAYAAVLSDAELAEEVPDTGERARVVEHRAELVAPARGGSETARRAAEDVLLAETDAEALGYRLGLAVELQAARVDYATPGPSLPPEASPAPLPAPLAAPPPPPGGAPPARPAGGTRPRRGSLNWLRRGRRRRTGLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MYK8</accession>
    <name>A0A0F7MYK8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_00055</name>
        <name evidence="3" type="ORF">AA958_34205</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH80831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH80831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH86440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="93" mass="10333" checksum="B9D8601C5A75285B" modified="2015-07-22" version="1">MNWLEWMGAGGISVPLMFLVYYALRRTKSAVEMLVTAHLRARAEREQRATMIAVAAALPEGGAAARFEEGQPAWLFYKHSEQGRPAIVTREAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MYT0</accession>
    <name>A0A0F7MYT0_9ACTN</name>
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        <submittedName>
            <fullName evidence="4">Isoquinoline 1-oxidoreductase</fullName>
        </submittedName>
    </protein>
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        <name evidence="4" type="ORF">AA958_00530</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
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        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
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        <location>
            <begin position="43"/>
            <end position="764"/>
        </location>
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            <end position="306"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="744"/>
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        </location>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM01008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH80901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="764" mass="80828" checksum="B9E08E2BA11EF970" modified="2015-07-22" version="1">MTGPNGARPYEGPGRRRFLGYVLAAPTLVAAAPLAPAPAAGAAPAVPDLTELLDLNDVMTAAALPTSGLITVEIEADGTVSFALPRAEVGQGITTSTAMLVAEELAVPPERVRVTLAEARPELLFNQLTGASNTTIATYTPIRVAAAVARHRLLTAAAAELGAPVGHLTLRDGTVHDRSGAAVGIGALAPKAAATRSEPVEVRLTAREDFTVIGRPHNRIDALDAVTGRKKFAMDLDVPGAKPTMVCRPPTINGKPGAVANLAEVAAMPGVTDVVPIDTGVAVRAATFGQCIDAVRALRVDWLPGTAEGKSDETVLRELAAAEPPMGLPPLTPHVEGKFTFHFRSNSALEPNCAIADVRPDRAEVWSALKSPVVAKEAIAARLGLPLGRVTVHVVQGGGSFGRKLFFDAALEAVEVSRRIGKPVKLMWHRADDARQGRTHPMATSRVRADYAGGAVLGFRQRHTSVATDFGHGLGELFTAMAARLPVGDIGFSQTFFHLTQSMPYEFGPATRLLNETDKGFNTGSMRNVYSPDVVCARELVVDRLAVKMGKDPYGFRRDFLRDARSRAVLAKAAEAGDWGRQMPEGTAQGIAFHSEYKSVSAALVEIDCRPGTVNRPIRDGVAGPRVTRAVFAVDVGLTVNPRGLQAQMMGCLMDGIAQTLTSSLHLRDGHFLEASWDNYFYTRQWNTPPELEIIVMPDTSDEPGGAGELGVAASMAAVACAYGRATGTMPTVFPINHGTLSFEPKPTVPPIPASPTDGLDQAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0B6</accession>
    <name>A0A0F7N0B6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 11">Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase</fullName>
            <shortName evidence="11">NN:DBI PRT</shortName>
            <ecNumber evidence="5 11">2.4.2.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">N(1)-alpha-phosphoribosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">cobT</name>
        <name evidence="14" type="ORF">AA958_03495</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 11">Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>5,6-dimethylbenzimidazole + nicotinate beta-D-ribonucleotide = alpha-ribazole 5'-phosphate + H(+) + nicotinate</text>
            <dbReference type="Rhea" id="RHEA:11196"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15890"/>
            <dbReference type="ChEBI" id="CHEBI:32544"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:57918"/>
            <dbReference type="EC" id="2.4.2.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Nucleoside biosynthesis; alpha-ribazole biosynthesis; alpha-ribazole from 5,6-dimethylbenzimidazole: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the CobT family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.21" evidence="5 11"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014759.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_03495"/>
    <dbReference type="EnsemblBacteria" id="AKH81401">
        <property type="protein sequence ID" value="AKH81401"/>
        <property type="gene ID" value="AA958_03495"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_03495"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.738"/>
    <dbReference type="OrthoDB" id="1765140at2"/>
    <dbReference type="UniPathway" id="UPA00061">
        <property type="reaction ID" value="UER00516"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008939">
        <property type="term" value="F:nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02145">
        <property type="entry name" value="BluB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02439">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1610.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00230">
        <property type="entry name" value="CobT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012825">
        <property type="entry name" value="BluB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003200">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017846">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023195">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036087">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02277">
        <property type="entry name" value="DBI_PRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52733">
        <property type="entry name" value="SSF52733"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02476">
        <property type="entry name" value="BluB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03160">
        <property type="entry name" value="cobT_DBIPRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="8 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nitroreductase" evidence="13">
        <location>
            <begin position="870"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="185"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="291"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="390"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="509"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="665"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="717"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="149"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="212"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="1396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00015486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AKH81401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="1429" mass="140181" checksum="6A4A4E8AC1582418" modified="2015-07-22" version="1">MGEGYGRMTDTGKLPEGHQPEPDDVAGGHHPAPAATPDTAPAVEGAADDDDFLFLPGAQGAWTDPGVPAPAGARGAEPATGAQRRPLHMGPPVPEQAGGVVRSLADRGPASGSADTREAVAAADAANAGGTGAGSAAQGAGGTPQPPAASAYTERTNQTAQAEEAGQPAENTVAGPGIAAVAEQDAPAGPAAAPGAVADQGAPAPGGNAADQTAAASGQSAPTAAVSGPPQAAGVPGQAPQQPVRTPGPPTVGPEYLDVTRVGATHLPGPQLGEIPPAPAGWTAVSQANGEALAQAQPREVGGEAPAPGAEAAPAQYAPAPNGEPAAAAQTTGGAPAPAPVDAAQAAVRRAAASAGASLGRGISANGAVANGRHEATGAEPADATHVRQPADGTADAATAAGQTNQPAPDGQPGAAAAPGSDPQTESGQPAAGAAQPAEGAAGRTPGGHAADGSAVPAGENGQPAADTAGSSGPEGAAAAQAPSGHAVNESAPHAVTVDGTAIAVSGVSEGSAAPQAQPANGTVPHAVPAVRSSSDAAAQPGAAAAVPGGAEGASAGNPAAAAAPQAGDNSRAPAGGQDDSDTGDRPADGPVLHAVPGDDTAAQAADSAVRTSGQAAADQAAAAAQANEQTGGDSAARQDRQGDAGQQLADAAVLHAVANGQPVNGAKARAANGQAVPGGQPSVPAARAASDEAATAGAVHAAAAGRRGVSLGVQNGAQAAASGTAGEAAAGSPSEAQPDGGAAQRTGAPVTQIRTRRRRGTAVSAPVTAGTPAGDAQAAQDTAAAPGASVPAQAAAPQPAPAEEAPATPVPAAAEAAPAADAPAATGDATPPAAAAPEAPAADAPAAPADEPAAPGFADAERAAVHRVMRERRDIRNGFRSDPVPHEVLLRVLEAAHTAPSVGHSQPWDFVVIRSEETRHRMHELAARQREAYAKSLPKGRAKQFKELKVEAIRDTPVNIVVTADPTRGGRHTLGRHTQPQMAPYSSALAVENLWLAARAEGLGVGWVSFFDERELVRELDLPEHLDVVAYLCIGYVDEFPDEPELVQAGWSKRRPLSWVVHEESYGRRALPGADPHDLLAETLEGIRPLDAKALGEAWERQKRMTKPAGSLGMLEIISAQLCGLSRKCPPPVPEPAAVAVFAGDHGVHAQGVTPWPQEVTGQMVANFLGGGAVCNAFATQVGAEVCVVDAGVAAELPATAGLVPRKVRKGTADMTAGPAMTREEALRAVEVGIETARDLVAAGNKALLTGEMGIANTTASAAIIAVFTDSEPADVTGRGTGIDDETYDRKVDAVRRAIEVNRPDPADPIGVLAAVGGLEHAALVGYILAGASLRTPVVLDGVSAGAAALVARAVAPEALAACIAGHRSPEPGHAAALTKLGLRPLIDLDLRLGEGTGALLALPLVQSAARAMHEVATFDAAGVTEKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0U2</accession>
    <name>A0A0F7N0U2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alanine dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_01280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014388.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_01280"/>
    <dbReference type="EnsemblBacteria" id="AKH81023">
        <property type="protein sequence ID" value="AKH81023"/>
        <property type="gene ID" value="AA958_01280"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_01280"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.282"/>
    <dbReference type="OrthoDB" id="1752728at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="2">
        <location>
            <begin position="10"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH81023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="316" mass="32944" checksum="A3CF8BB338D9E081" modified="2015-07-22" version="1">MKALQFDRFGPPDVIVLRDVPQPEPGPGQIRIAVRACGLTPADWHVVDGLLADHLPPLPRGLGLEVAGTVDALGEGVTGVQIGDRVFGPATFDGPTAGAAEYALMPAWARIPEGVTAEQAAALPMAAETAWRALDDLGVQPDELLLVHGAGTTVGEAAVRFALHRGIRVIATAGPTRAAALEEIGAQVTAYGEGMAERVGALTPGPVDRALDTTPTGGRIDRADQPSPAGGSLPTLIELTGDPDRVLTVSDFAAAAELGVRITTEIRYDQMKEFARLAGEGILVVPVARTYTLDQIQEAAKLSQSRRPGGKLMLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0U6</accession>
    <name>A0A0F7N0U6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alkaline phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_01025</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH80984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014350.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_01025"/>
    <dbReference type="EnsemblBacteria" id="AKH80984">
        <property type="protein sequence ID" value="AKH80984"/>
        <property type="gene ID" value="AA958_01025"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_01025"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.226"/>
    <dbReference type="OrthoDB" id="165142at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018946">
        <property type="entry name" value="PhoD-like_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038607">
        <property type="entry name" value="PhoD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032093">
        <property type="entry name" value="PhoD_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09423">
        <property type="entry name" value="PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16655">
        <property type="entry name" value="PhoD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519124" evidence="1">
        <location>
            <begin position="21"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="PhoD_N" evidence="3">
        <location>
            <begin position="35"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="PhoD" evidence="2">
        <location>
            <begin position="141"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH80984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="509" mass="55507" checksum="4C5567E1EC1179E3" modified="2015-07-22" version="1">MLRGGLAASAALAVPTLSGGAPAQALAGRPGAAWGVQVGDVTAQGGTVWVRADRPARMVVETSATDSFRTVQRRRGPLLGPGTDYTGTVRLHGLPPGEQVHYRVVLEDADDPRRSGEPVAGTFRTAPGRRRDVRFVWSGDVAGQGWGINPDRGGYRVYAEMQGLDPDFFLHSGDTVYADGPLSAEVPLPDGTVWRNLVTEEKSKVAETLAEYRGNFRYNLLDENVRRFNAQVPIVVQWDDHEVVNNWYPGEILTDARYTERRADVLAARARRAFAEYFPVPALGADGAGRVYRKVSYGPLLDVFVLDMRTYRNANSDGLAPDDVHGILGREQLAWLKRELQRSRAEWKVIASDMPLGLVVPDGTNVEAVAQGDPGAPLGRELQIAELLRHVKQRRITGTVWLTADVHHTSAQHYDPARAGFKDFAPFWEFVTGPLHAGAFPGSALDGTFGPERVFLKAPQTGNVAPSQGFQFYGEVLIDGGSRELTVRLREEGGAVLFTKVLQPGLVGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-10-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0V6</accession>
    <name>A0A0F7N0V6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_01085</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH80994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH80994">
        <property type="protein sequence ID" value="AKH80994"/>
        <property type="gene ID" value="AA958_01085"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_01085"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH80994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="152" mass="16663" checksum="391E8B635855117E" modified="2015-07-22" version="1">MVIGTRTSTKAPASTWASWLLQAPCGMRMFSLSEATGQCRVSARTVRVRSARRVRSAPARIFSRPRNCWSVTLVSSVSVVVNGFRPMGPGACRTPTQLAGPGRPDVQRLPETRNGASSVYLSWAVTSKPRTRRCTSHPCRRLALCCVRMLTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N104</accession>
    <name>A0A0F7N104_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cytochrome bc1 complex Rieske iron-sulfur subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cytochrome bc1 reductase complex subunit QcrA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">AA958_01455</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Iron-sulfur subunit of the cytochrome bc1 complex, an essential component of the respiratory electron transport chain required for ATP synthesis. The bc1 complex catalyzes the oxidation of menaquinol and the reduction of cytochrome c in the respiratory chain. The bc1 complex operates through a Q-cycle mechanism that couples electron transfer to generation of the proton gradient that drives ATP synthesis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014414.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_01455"/>
    <dbReference type="EnsemblBacteria" id="AKH81049">
        <property type="protein sequence ID" value="AKH81049"/>
        <property type="gene ID" value="AA958_01455"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_01455"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.320"/>
    <dbReference type="OrthoDB" id="1632945at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014349">
        <property type="entry name" value="Rieske_Fe-S_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005805">
        <property type="entry name" value="Rieske_Fe-S_prot_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10134">
        <property type="entry name" value="PTHR10134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00162">
        <property type="entry name" value="RIESKE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519146" description="Cytochrome bc1 complex Rieske iron-sulfur subunit" evidence="12">
        <location>
            <begin position="31"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="Rieske" evidence="13">
        <location>
            <begin position="59"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="31"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AKH81049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="153" mass="15404" checksum="9B58C08EC5B6391E" modified="2015-07-22" version="1">MTRSPHPARLTARRTVVAAVGAGGLTAALAACGDDSGDGGSGDSGSTEVRPQEGGKDDGAQLGTTDEVPEGGGKIFKDRKVVVTQPEPGEFRAFSAVCTHQGCLVSSVEDGTINCACHGSRFALADGSVAQGPATQPLPAEDVRVDGDVLRQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N1E2</accession>
    <name>A0A0F7N1E2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_02585</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014606.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_02585"/>
    <dbReference type="EnsemblBacteria" id="AKH81243">
        <property type="protein sequence ID" value="AKH81243"/>
        <property type="gene ID" value="AA958_02585"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_02585"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.553"/>
    <dbReference type="OrthoDB" id="1584918at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06583">
        <property type="entry name" value="PGRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036505">
        <property type="entry name" value="Amidase/PGRP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002502">
        <property type="entry name" value="Amidase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01510">
        <property type="entry name" value="Amidase_2"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55846">
        <property type="entry name" value="SSF55846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002518958" evidence="2">
        <location>
            <begin position="41"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetylmuramoyl-L-alanine amidase" evidence="3">
        <location>
            <begin position="282"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH81243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="663" mass="71713" checksum="C6FE3D1646A13EDE" modified="2015-07-22" version="1">MPPTPATRLRVNLRRRPWATAAVAAGLLLPLTSASLPAAAGGGEDAAAPATRQAAYAAAADEYGVPESVLLGVSYLESRWDTHAGEPSTDAGYGPMHLTDAPTVLAEDHHGGTAEDPRGDTERPVGDETFGPALTTLYAAAELTGTDAATLRAKPAENIAGGAALLAAYQEDLGAPASADPADWYGAVAKYAGAAYEQDAAAFADEVYATIRDGAARTTDDGHAVRLAADPSVAPRQRWLGELGLPRLTDEEVECPDRLGCEWIPATYRQTNPDDIQAYVNHDKADRPRDQKIEYIVIHDTEGRYPGVINMVQDPNRAASWQYTLRSSDGHIAQHIKHKDVAWQAGNWNINAKSIGLEHEGFAKDQGTWYTEAMMRSSATLVRYLAATYDIPLDRTHIIGHDNVPGTTTANIRGMHWDPGPYWDWERYFELLEAPLRSPGGFSKSMVMIKPDFAENKPQFTGCSYESGSDPKEPCPLAPSSSVILHSQPDADSPLLADIGLHPDGRASDMHVSDIGSRASAGQTYAVAERKGDWVAIWYHGLKGWFHNPAGARVADYTAGKIVTPKPGKESVPVYGRAYPEQAAYPPEIPYQPISAHPYEFKAGQAYSYGGTVPGEYYRAVTFDGSAPGDRTVVRGKMKYHIIQIGHRIGFVNADDVTVRRVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N1G6</accession>
    <name>A0A0F7N1G6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AMP-dependent synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_09385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015751.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_09385"/>
    <dbReference type="EnsemblBacteria" id="AKH82405">
        <property type="protein sequence ID" value="AKH82405"/>
        <property type="gene ID" value="AA958_09385"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_09385"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1981"/>
    <dbReference type="OrthoDB" id="164380at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="23"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="634" mass="69184" checksum="492D2D537A51604F" modified="2015-07-22" version="1">MTETETQTKLDSRPPSVATLFLDRVESTPDREAFQYPVPAATAGEGDEWRSLTWAQSAERVFAIAAGLLDLGLQPEERVALACNTRLEWILTDLGILCAGGANTTVYPSTNAEETAYILADSGSRVLVAEDAAQLAKAREMRAGLPDLAHVVVVEAEGTGEELAAEGDPDGWVLSLAELERRGADYLEKHPEAVREHIRALRPEQLATLIYTSGTTGRPKGVRLAHDAWSYMGYAIEGIELVMPEDTQYLWLPLAHVFGKVLTAGHIKVGHVMAVDGRIDKIIENLPVVRPTQMCGVPRIFEKVYNGVAAKAKAGGGAKYKIFLWAAEVAREYARVTQDNHRRTGKRTAPVGLAAKHALADKLVYGKFRAAFGGRMRGMVSGSAALAPEIGYFFDGAGVPILEGYGLTESAAASFCNRLETYRTGTVGKPLPGCEVRIADDGEILLRGPGIMQGYHGLPEKTAEVLEDDGWFHTGDIGELSDDGFLRITDRKKDLIKTSGGKYIAPSEVEGQFKAVCPYVGSILVIGADRNFCTALISLDEVALTGWAKENGLADRSYAELVASPEARELVDGYVQQLNERLQRWQMIRKFRILPRDLDVEHGELTPSLKLKRPVVEKEYADLIEDMYAGAREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N1H3</accession>
    <name>A0A0F7N1H3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Hrp-dependent type III effector protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AA958_02465</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the four-carbon acid sugar kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014587.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_02465"/>
    <dbReference type="EnsemblBacteria" id="AKH81224">
        <property type="protein sequence ID" value="AKH81224"/>
        <property type="gene ID" value="AA958_02465"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_02465"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.527"/>
    <dbReference type="OrthoDB" id="771666at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037051">
        <property type="entry name" value="4-carb_acid_sugar_kinase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010737">
        <property type="entry name" value="DUF1537"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031475">
        <property type="entry name" value="NBD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042213">
        <property type="entry name" value="NBD_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17042">
        <property type="entry name" value="NBD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07005">
        <property type="entry name" value="SBD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SBD_N" evidence="7">
        <location>
            <begin position="17"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="NBD_C" evidence="8">
        <location>
            <begin position="266"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH81224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="449" mass="45007" checksum="90D9B06FF512F663" modified="2015-07-22" version="1">MSGPVRARPAGRRAAVLVAADDLTGANATAAGFARAGLRAVTVGADQGPDVLAGLAERFDAVVVSTDSRHCPPAEAARRVTGAVRAGWPAELVSNRVDSTLRGNVGASTEALLAAVRAASGRRAVALCAPAHPEAGRHTVQGTQLLDGVRLEETELARDPRSPVPTSDIAELLRRQADLRIARVPLSVVTAEAGTLQAHLDKVVAEGAEVVVADALTVEHLERTAAAAVAAGGGEIVWTGVDSGPGSVALARALGITGRAAGFPVLAVSGSATALTRAQLARLRAVEPVRVVRPVTAPGSPVPEPAATAEALAAELAAAGPGEVVLLATVLEDADVVALDPADAARLPAELARTVRTALERQPVDGLFATGGDVSAALFAALGAAGLDVEDELEPLAVAGGFVGGDWAGLPVVTKGGLIGGADTTVACVAHLRRAAAAARRHVPAAGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N1H5</accession>
    <name>A0A0F7N1H5_9ACTN</name>
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        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_09520</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_09520"/>
    <dbReference type="EnsemblBacteria" id="AKH82425">
        <property type="protein sequence ID" value="AKH82425"/>
        <property type="gene ID" value="AA958_09520"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_09520"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2007"/>
    <dbReference type="OrthoDB" id="1159548at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043148">
        <property type="entry name" value="TagF_C"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="675"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="675"/>
            <end position="693"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH82425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="703" mass="75480" checksum="D57E40B1C299BD22" modified="2015-07-22" version="1">MPFAGIAPRRAVQLMALTTLLAAYCAQLVGALKPNVPLLVAAAAGGLALDLYLQHRQPGLLSLLSRVRFDVMVRQLLRDMLILFGLLQIDGIEPLREQSALTVMLLSSYLVHFLIQGVTIMVRRDRTVPVVTRNVDVSALGLAPAPPRILARRSSHRLLYLSVPVTVGLLTTAATADAVWGVLGLGISLALSGGGALYLATWLLPAKRTADDQRVREWFAAWLQEYQPTVGLYFSGGATSAYQANMWVSTLAALDGKPLIVLRERFMVQKITATDVPIVCLPKVADLMLLEHSTLKMLLHPANSGKTSQVLRIPTIKHAFTNHGESDKLSSCNPYAKAYDEVWVAGPAARARYQLADIGVDDRDVVEVGRPQLAPIRPYAGPPPAGGLTTVLYAPTWEGWDGNPGNTSVVLAGENIVRELLADPQVRLLYKPHPLTGSVDPRAGEANKRIQAMITEANAAMVAEAAAGGQGAGGRGAERPGPEAAAELARVQAELDELATTTFRTGADEVERMLVQSSPEAGRAEAVQAATAAWEEAYWASLPAWEHQIITDSRPGIYACFNVADVLISDVSSVISDYLTSEKPYAVANTSGMTEAEFKAEFPTVRAGTILGPRAKQIPALLEAVRDPEHDTLVRARAELKEHLLGPSEPPSLVRFNAAAVALCAKADARAARIEARGESDIPSQRRDAAEELELEPEEPAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N1Q0</accession>
    <name>A0A0F7N1Q0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AbaA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_02980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014672.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_02980"/>
    <dbReference type="EnsemblBacteria" id="AKH81309">
        <property type="protein sequence ID" value="AKH81309"/>
        <property type="gene ID" value="AA958_02980"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_02980"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.636"/>
    <dbReference type="OrthoDB" id="1903180at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="17"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="82" mass="8725" checksum="8A15581937FADECD" modified="2015-07-22" version="1">MERIYNGMPAADLGTEGWHKPWSGGNGGNCVEAMKLRDGRIAVRHSAHPDGPALIYTPGEMDAFIEGAKAGEADFLLSRSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N1T3</accession>
    <name>A0A0F7N1T3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DSBA oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_03410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014746.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_03410"/>
    <dbReference type="EnsemblBacteria" id="AKH81388">
        <property type="protein sequence ID" value="AKH81388"/>
        <property type="gene ID" value="AA958_03410"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_03410"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.724"/>
    <dbReference type="OrthoDB" id="1805428at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13462">
        <property type="entry name" value="Thioredoxin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="1">
        <location>
            <begin position="1"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="170" mass="18554" checksum="C4E6DB6367054078" modified="2015-07-22" version="1">MENDVNGAPVLDVWCELQCPDCRTALTDLRALRERYGDRLDIRLRHFPLDKHQHAMAGAQAAEEAFAQGKGWEYAEAVLAVAETFGKRGEPLLVETARELDLNAAEVETALVDGRHFLIVDADVAEGKAIGVTGTPTYVIGGERLDGGKSQEGLRERIEEIADRLLAAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N1V3</accession>
    <name>A0A0F7N1V3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LacI family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_10450</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH82575">
        <property type="protein sequence ID" value="AKH82575"/>
        <property type="gene ID" value="AA958_10450"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_10450"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2202"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH82575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="314" mass="33125" checksum="24B1020ABCE712A7" modified="2015-07-22" version="1">MINGSDQVSEQARTAVERAVAELGYVPNRAARALAAGSADAVALVIPEPETRLFSEPYFSDIVRGVSAELAETDKQLLLTLIRSPRERERLAAYLSADRVDGVLLVSVHEGDPLPEMLAAMGLPAVLNGRRAAGEAVPYVDSDNTGGAQAAVGHLIGRGRSAIATITGPSDMYVASCRLEGYRQALKGAGREEDAGLVAVGDFTEEGGRRAMQELLERRPALDAVFAASDVMAAGALQVLRAAGRTVPDEVAVVGFEDSPVARHTDPPLTSVRQPTEEMGRAMVRVLLDGIDAKEATQGRHVVLPTELVVRASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N1W6</accession>
    <name>A0A0F7N1W6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cysteine desulfurase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_06810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015323.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_06810"/>
    <dbReference type="EnsemblBacteria" id="AKH81971">
        <property type="protein sequence ID" value="AKH81971"/>
        <property type="gene ID" value="AA958_06810"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_06810"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1424"/>
    <dbReference type="OrthoDB" id="446447at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotran_5" evidence="1">
        <location>
            <begin position="33"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="460" mass="47206" checksum="DF55536228FB3513" modified="2015-07-22" version="1">MSASTLTPACLPVLGRDVRAPLVTGGDAEYAALDYAASAPALQRVWDDVAAYAPYYGSVHRGAGYLSQLSTELFESSRATVAGFLGCRPDDQVVFTRSTTDSLNLLATALPPGTEVYVFETEHHAALLPWHHGGSAAGRVTVLAAPGGPGQAVAALDSALAARVGDGPALVCVTGASNVTGELWPVRELTAAAHRHGARLVLDAAQLAPHHPVDVADLGVDWVAFSGHKLYAPFGAGVLAGRADWLQAAPPYLAGGGASRRVLRTADGGVDVEWQTTAARHEAGSPNVIGAYAIASACKALTEAGFGELVARERALVARVLEGLAELPGVRVLSLFGADAARVGVISFVVDGWSSSHLAAALSAEHGIGVRDGLFCAHPLVRALLGEAGEPAECGGGAGDGERPLNAVRVSFGAGTPDEHVDRFLAALGSLVRDGARWSYRTVDGRCVPASGEDRTATAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N1Z7</accession>
    <name>A0A0F7N1Z7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">CRISPR-associated endonuclease Cas1</fullName>
            <ecNumber evidence="8">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cas1</name>
        <name evidence="10" type="ORF">AA958_03715</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer, forms a heterotetramer with a Cas2 homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CRISPR-associated endonuclease Cas1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="8"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014801.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_03715"/>
    <dbReference type="EnsemblBacteria" id="AKH81443">
        <property type="protein sequence ID" value="AKH81443"/>
        <property type="gene ID" value="AA958_03715"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_03715"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.782"/>
    <dbReference type="OrthoDB" id="1581397at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004520">
        <property type="term" value="F:endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043571">
        <property type="term" value="P:maintenance of CRISPR repeat elements"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09719">
        <property type="entry name" value="Cas1_I-E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01470">
        <property type="entry name" value="Cas1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033641">
        <property type="entry name" value="Cas1_I-E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002729">
        <property type="entry name" value="CRISPR-assoc_Cas1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042206">
        <property type="entry name" value="CRISPR-assoc_Cas1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019851">
        <property type="entry name" value="CRISPR-assoc_Cas1_ECOLI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042211">
        <property type="entry name" value="CRISPR-assoc_Cas1_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01867">
        <property type="entry name" value="Cas_Cas1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03638">
        <property type="entry name" value="cas1_ECOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="281"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="289"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AKH81443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="320" mass="34583" checksum="F899D45F6E659D9E" modified="2015-07-22" version="1">MTTVSRRGASSPLELTRISDRLSFVYLERAVIHCADNAITAADGDGVRHLPSATIGTLLLGPGTKISQQAVRLLGESGVGIVWVGEHGVRYYAGGRALSRSAALAEAQARLWANPRTRLDVARSMYALRFPDDDPAGRSRRELLGKEGDHVKSCYRAEAARTGIRWRGRRYVQGDFASGDAPNQAVTAAGQCMYGIAQSVVAALGCIPGLGFVHSGHELSFALDIADLYKTEIGIPVAFDVAAESQEDIGPRVRRALRDRVHATRLLERCVHDVKELLTPGTTADSVEESDAPQRDRVALQSDRGEEVESGRNLGEGLIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N201</accession>
    <name>A0A0F7N201_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ornithine cyclodeaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_00390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH80877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014243.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_00390"/>
    <dbReference type="EnsemblBacteria" id="AKH80877">
        <property type="protein sequence ID" value="AKH80877"/>
        <property type="gene ID" value="AA958_00390"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_00390"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.93"/>
    <dbReference type="OrthoDB" id="1193876at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003462">
        <property type="entry name" value="ODC_Mu_crystall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023401">
        <property type="entry name" value="ODC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13812">
        <property type="entry name" value="PTHR13812"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02423">
        <property type="entry name" value="OCD_Mu_crystall"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001439">
        <property type="entry name" value="CryM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH80877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="307" mass="31959" checksum="4053D110833D7F9D" modified="2015-07-22" version="1">MSVLLLDDDDVRSRLDAPTAVRAVRNALTAAHEGALHAPPRVHADLGGGRLVFTAGHLRAERLFGFRAYDTLVGAEQLVALWDGDGGRLRAVVHGDELGARRTGAIGAVAVDTAARPGPIRLGVVGAGRHAWTQLWAICAVRQVVEATVASRTPERAQAFARRAAEELGVRVRAVPRVEEAVRDHDVVVLATNSTAPVLDAEWVAPGTHVTTLGPKTVSRHEVPAALAERADVILTDSVAQAAAYGEPHVLPVDRMIGLGAVLVGAAAGRSSPDEITVFCSVGLAGTEVAVAAALGEVLQPARRSPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2G2</accession>
    <name>A0A0F7N2G2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_04475</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014924.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_04475"/>
    <dbReference type="EnsemblBacteria" id="AKH81569">
        <property type="protein sequence ID" value="AKH81569"/>
        <property type="gene ID" value="AA958_04475"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_04475"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.944"/>
    <dbReference type="OrthoDB" id="1479518at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
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        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="180"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="253"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="284"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="99"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH81569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="319" mass="34384" checksum="E927EFF5B535DA7B" modified="2015-07-22" version="1">MAQIARMLLRRIALLVPLMLGIVLFVFLVMRFSDIDPAVANFQGANPTEQQLEEYREEHGLNDPLPVRYAAFVGDLLKGDMGLSALNGRPVIDQVTTALPLTMQLTFLGLVLAIVLSVLFGVTAAIYRDRIPDQVIRIVSLIGVAAPAFWVALLLIQYLAVDWGWFPSGGYVNPGDSFTGWLKTMTLPAIALSLHVAAQLTRIVRTAVVEELDKDYVRTAIGSGLPPVVVVGRNVLRNALVNPLTVLGLRVGYLLGGAVVIETIFSLPGMGTLMINAVKNGDPAVVQGVVLTVAVAFVVVNLVIDILYLLVNPRLRSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2J2</accession>
    <name>A0A0F7N2J2_9ACTN</name>
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        <submittedName>
            <fullName evidence="8">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_08235</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP011492">
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    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_08235"/>
    <dbReference type="EnsemblBacteria" id="AKH82221">
        <property type="protein sequence ID" value="AKH82221"/>
        <property type="gene ID" value="AA958_08235"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_08235"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1737"/>
    <dbReference type="OrthoDB" id="1254678at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="40"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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        </location>
    </feature>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH82221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="413" mass="43634" checksum="3C818A4E6F7F8EFE" modified="2015-07-22" version="1">MSPLTTEKRDTPPAAPAAGGSRGALAGALLDAMRNNMRQYGMLVALGLIVVVFQVWSDGTLLLPRNVSNIVQQNSYILILAMGMMIVIIAGHIDLSVGSLCAFASAMSAVMMVNHDFPWPLALVCSLLIGAAAGAWQGFWIAYVGIPSFIVTLAGMLVFRGLTQIVLEGQSLSPFPKGFQNMAQGFLPETGPDTNYHNLTLLLGLCVGLFLLWQEWRDRRRQLSYELDVLPYPLWLGKCAFIVAAVVAATLMLASYRGVPVVLLIMAGLLVSLGYVMRNVVVGRHVYALGGNRAAATLSGVKDKRVTFLVFVNMGVLAALAGCVYAARLNAGVPKAGEMFELEAIAAAFIGGASMSGGIGTVFGAVIGGLVLGVLNNGMSLVGLGTDYQQVIKGLVLLAAVGFDIWNKRRAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2Q4</accession>
    <name>A0A0F7N2Q4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_08730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_08730"/>
    <dbReference type="EnsemblBacteria" id="AKH82301">
        <property type="protein sequence ID" value="AKH82301"/>
        <property type="gene ID" value="AA958_08730"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_08730"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1842"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH82301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="330" mass="36723" checksum="FED984F55082C0D0" modified="2015-07-22" version="1">MTRPPRVREAGAGRRAHPEPVFVLAPPRSLSTITLALLSGHPQIYGFPELLVFAGATVRDLIRGGTAKGYPPELHRGRLSGLYRAIADVHEGEQTPEAVNRAGEWLARRADWPAPRVLAHLLKEVAPLVGAEKSPDTVATDEMLARCLDHYPNARYLHLTRHPVTTQRSMHAQEPKLYTHRAVRLVGAASSWYLAHSRIRDRLAALPAHQWIRVRGEDLLRRPGTTLPAVLDWLGLDSGDAVIARMLQTERWRFAGFGPSGDLYGGDRTFLTHARLRPVPDPGPVRFDPAWGLPEEMVRRMSRLAAELGYDVAEARRRQVVDQRLTPGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2Q9</accession>
    <name>A0A0F7N2Q9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sugar kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_08780</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FGGY kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_08780"/>
    <dbReference type="EnsemblBacteria" id="AKH82306">
        <property type="protein sequence ID" value="AKH82306"/>
        <property type="gene ID" value="AA958_08780"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_08780"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1850"/>
    <dbReference type="OrthoDB" id="1619686at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018483">
        <property type="entry name" value="Carb_kinase_FGGY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00445">
        <property type="entry name" value="FGGY_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FGGY_N" evidence="3">
        <location>
            <begin position="4"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="FGGY_C" evidence="4">
        <location>
            <begin position="248"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="503"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH82306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="533" mass="54150" checksum="2CC08AEA7946B7EE" modified="2015-07-22" version="1">MGIVAGLDSSPEGTNIVVCDADTGAVLKQGYAPHPVSESADETTPAYEADPQTWLLSLGEAADGGVLEGVQAIGVAAQQHAVIPLDAAGAPVRHALTGNDKRAQGAAADLAGELGGRAAWAEAVGAVPDAKLPVTKLRRFAATEPDHAKRTAQLMTPHDWLVWQLLGRPARRTTDRGSASTTGYWSAHAGEWRRDLVELALGHEAGLPEVLGPAEAAGRTPEGLLISAGTGETMAAVFGLGLGTGDAVVTLGASGAVYAVHDAALPDAGGTITALADATGMHLPVVHTLNAVRALRGAAELLGLAPTDLERLSELALTSTPGAHGLVLLPYLDGERTPSLPQTAGSLHGLRRESMRPEHLARAAFEGMLCGLADALEVLRTRGVRVRRVFLLGAAAGLPAVQALAPAIFQAQVVVPASADYAALGAARQAAWALGVAEGRLGADAPPVWETGPHETFEADEEEALGQAVRQQYAAVRESVYPGALGLAAGTGGLAAGTAGAVAAGDTAGGEPGPGQPGSEDQEQRAEQEVPQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3D6</accession>
    <name>A0A0F7N3D6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_14180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH83190">
        <property type="protein sequence ID" value="AKH83190"/>
        <property type="gene ID" value="AA958_14180"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_14180"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2985"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="60" mass="6383" checksum="C7E57F6739F0AAAC" modified="2015-07-22" version="1">MHGVATLLADGLMTLATAGETDRQTERVVEALLTGLAQEPGGTWPAPRSTHTERRARGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3Q8</accession>
    <name>A0A0F7N3Q8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytochrome c oxidase polypeptide 4</fullName>
            <ecNumber evidence="10">7.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cytochrome aa3 subunit 4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Cytochrome c oxidase polypeptide IV</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AA958_06850</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Part of cytochrome c oxidase, its function is unknown.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>4 Fe(II)-[cytochrome c] + 8 H(+)(in) + O2 = 4 Fe(III)-[cytochrome c] + 4 H(+)(out) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11436"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="7.1.1.9"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Associates with subunits I, II and III to form cytochrome c oxidase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the cytochrome c oxidase bacterial subunit CtaF family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.9" evidence="10"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015330.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_06850"/>
    <dbReference type="EnsemblBacteria" id="AKH81978">
        <property type="protein sequence ID" value="AKH81978"/>
        <property type="gene ID" value="AA958_06850"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_06850"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1432"/>
    <dbReference type="OrthoDB" id="1844113at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021050">
        <property type="entry name" value="Cyt_c_oxidase_su4_actinobac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12270">
        <property type="entry name" value="Cyt_c_ox_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017385">
        <property type="entry name" value="CtaF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-1278">Translocase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="88"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR017385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AKH81978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="132" mass="14653" checksum="7627B993DA3EDBB2" modified="2015-07-22" version="1">MKIQGHMFGWLAAFVLVAAIVYGYWSKEPVGTTALFLAFGLTAMIGYYLVFTARRVDTGAQDNKEAEVADDAGELGFFSPHSWQPLSLAIGGALAFLGIVLNWWLLYFSIPVILVGLYGWVFEYYRGADQNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N472</accession>
    <name>A0A0F7N472_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF397 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_07905</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015519.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_07905"/>
    <dbReference type="EnsemblBacteria" id="AKH82169">
        <property type="protein sequence ID" value="AKH82169"/>
        <property type="gene ID" value="AA958_07905"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_07905"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1664"/>
    <dbReference type="OrthoDB" id="1996962at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="10"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="67" mass="7204" checksum="1959849E84DE78F2" modified="2015-07-22" version="1">MDRSDLAGVHWYKSSYSDGQRDCIEVAVADGVVAARDSKDPSGPVLTFAPDAWRAFVAAVRGGEYGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4E4</accession>
    <name>A0A0F7N4E4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Branched-chain amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AA958_08445</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AzlC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015606.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_08445"/>
    <dbReference type="EnsemblBacteria" id="AKH82258">
        <property type="protein sequence ID" value="AKH82258"/>
        <property type="gene ID" value="AA958_08445"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_08445"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1783"/>
    <dbReference type="OrthoDB" id="1866750at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011606">
        <property type="entry name" value="Brnchd-chn_aa_trnsp_permease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34979">
        <property type="entry name" value="PTHR34979"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03591">
        <property type="entry name" value="AzlC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="47"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="134"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="166"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="194"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="232"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AKH82258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="278" mass="27536" checksum="D9BE0DE8A3FC53DC" modified="2015-07-22" version="1">MSSMAVMRSIWRTLRGDLARDIALVCAADTLVGVSFGAIAVGEGLPLWLPVLLSVVVFAGAAQFMFVGIVASGGTALAAVAAGLLVNARHVPFGFTVGDALGGGRLRRLAGSHLMIDETVAFALAQRDPVRRRAAYWACGVGLFACWNAGVVLGALGGTAVSDTDAFGLDAAFPAVLLALVLPSLREAGTRRAALVGVGVALAAAPFLPAGVPVLLALAGLAVAGTGGERAREQGSGAVAEGGPVSGRVAEGGVPGGGAPGSGDDEPGAGSYDEERVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4W7</accession>
    <name>A0A0F7N4W7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_13340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016382.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_13340"/>
    <dbReference type="EnsemblBacteria" id="AKH83051">
        <property type="protein sequence ID" value="AKH83051"/>
        <property type="gene ID" value="AA958_13340"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_13340"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2806"/>
    <dbReference type="OrthoDB" id="1564925at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH83051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="295" mass="30456" checksum="A2445A093644D2AE" modified="2015-07-22" version="1">MTVDKTGDLTATRVHHPGAIAAAAAARRPAASPLGDGDPGRAMIIAADHPARGANAVGGDAHAMADRGLLLERLCLALERPGVTGVLATADILEDLLLLGVLDGKSVFGSMNRGGLAGSSFEIDDRFTGYDAETIAAMGFDGGKMLTRIALDDPATAATLESSARAVDALADRRLIAMVEPFLSRWQDGRVRNDLSPDAVVTSVSIASGLGRRSAYTWLKLPVVPDMERVVAATTLPVLLLGGDTGGAEGQRAVFDAWRGALRLPGVQGLVVGRSLLYPADGDVSGAVDRAVSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N519</accession>
    <name>A0A0F7N519_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_17740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017047.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH83745">
        <property type="protein sequence ID" value="AKH83745"/>
        <property type="gene ID" value="AA958_17740"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_17740"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3735"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH83745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="66" mass="6644" checksum="8C87C42C4F1B0664" modified="2015-07-22" version="1">MSEFDPPPGVPVRYRGARGRQVEVVTGLVVAATLFGGGAALGEWLAVGEDAGAATGVSLERCAADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N576</accession>
    <name>A0A0F7N576_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phosphate ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">pstB</name>
        <name evidence="5" type="ORF">AA958_18055</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017095.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_18055"/>
    <dbReference type="EnsemblBacteria" id="AKH83795">
        <property type="protein sequence ID" value="AKH83795"/>
        <property type="gene ID" value="AA958_18055"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_18055"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3797"/>
    <dbReference type="OrthoDB" id="1416748at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015415">
        <property type="term" value="F:ATPase-coupled phosphate ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03260">
        <property type="entry name" value="ABC_PstB_phosphate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005670">
        <property type="entry name" value="Phosp_transpt1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43423">
        <property type="entry name" value="PTHR43423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00972">
        <property type="entry name" value="3a0107s01c2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH83795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="258" mass="28169" checksum="3197F6F8F0608BCA" modified="2015-07-22" version="1">MAKRIDIGDLTAYYGDFKAIDGISMAVEPKSVTAFIGPSGCGKSTFLRTINRMHEVIPGARVEGKVMLDDENLYGSGVDPVSVRRVVGMVFQRPNPFPTMSVYENVAAGLKLNARYKKSELDDVVEKSLRGANLWNEVKDRLSRPGSGLSGGQQQRLCIARAIAVEPQVLLMDEPCSALDPISTLAIEDLIGDLKTRFTIVIVTHNMQQAARVSDRTAFFNLAAVGEPGRLIEVGDTDKIFSNPEEKATEDYISGRFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5A9</accession>
    <name>A0A0F7N5A9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Amino acid ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_10590</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015939.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_10590"/>
    <dbReference type="EnsemblBacteria" id="AKH82598">
        <property type="protein sequence ID" value="AKH82598"/>
        <property type="gene ID" value="AA958_10590"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_10590"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2229"/>
    <dbReference type="OrthoDB" id="1191583at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015424">
        <property type="term" value="F:ABC-type amino acid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030679">
        <property type="entry name" value="ABC_ATPase_HisP-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014343">
        <property type="entry name" value="Ectoine_EhuA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039085">
        <property type="entry name" value="ABC_ATPase_HisP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03005">
        <property type="entry name" value="ectoine_ehuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="7"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="39"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH82598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="256" mass="28580" checksum="EEF578523CF8DCD3" modified="2015-07-22" version="1">MDGSELIRFHNVTKRFGDNVVLDDLCFDVSSGKHVTLIGPSGSGKTTILRLLMTLVKPDSGTIKVNGDYLFHEERNGKLEPAGENHVREVRKNIGMVFQQFNLFPNMKVMRNITEAPVHVLGMAKDEAEARARELLELVGLTEHIDKYPTQLSGGQQQRVAIARALAMRPQVLLLDEVTSALDPELVAGVLDLLRDIARTTDITMLCVTHEMNFARDISDDVLMFDEGKIIESGPPEKIFSDPENERTQQFLNAIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5L9</accession>
    <name>A0A0F7N5L9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_11245</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AKH82709">
        <property type="protein sequence ID" value="AKH82709"/>
        <property type="gene ID" value="AA958_11245"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_11245"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2370"/>
    <dbReference type="OrthoDB" id="1484726at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH82709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="217" mass="23644" checksum="25FFACCF95FB139A" modified="2015-07-22" version="1">MRTHLVWDWNGTLFHDIHAVIEATNASFTELGLPPITLERYRELYCVPVPRFYERLMGRLPTAEEWEIMDETFHRHYWVRAEEAALADGAAELLAQRRAAGQTQSLCSLAPHEQLMPIVRSHGIADHFVRIDGRTGPSDSGKATHMVRHLGALQGIDPARTVVIGDAVDDAVAARHAGVRAVLYTGGSHSRASLEAAGVPVVDSLAEAVAAADELAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5T4</accession>
    <name>A0A0F7N5T4_9ACTN</name>
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        <submittedName>
            <fullName evidence="2">ArsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_11800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016139.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH82803">
        <property type="protein sequence ID" value="AKH82803"/>
        <property type="gene ID" value="AA958_11800"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_11800"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2480"/>
    <dbReference type="OrthoDB" id="1800563at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="6"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="111" mass="12208" checksum="782D36646473E4B0" modified="2015-07-22" version="1">MREVSQPAAEAIRMVDVLRALADPVRLEVVLRLAATGEESCTAIGGDLDVHQTTMSHHYRVLREAGVTWTTVRGRTRLVRLRRDDLDSLFPGLLDSVLNGAAASDDAVTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5U1</accession>
    <name>A0A0F7N5U1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AA958_15535</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016698.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_15535"/>
    <dbReference type="EnsemblBacteria" id="AKH83386">
        <property type="protein sequence ID" value="AKH83386"/>
        <property type="gene ID" value="AA958_15535"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_15535"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3270"/>
    <dbReference type="OrthoDB" id="692375at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="10">
        <location>
            <begin position="282"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="344"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="81"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="107"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="123"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="139"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AKH83386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="562" mass="58767" checksum="03E059781A014CD7" modified="2015-07-22" version="1">MRSPFSSVRAKAAVGATAVVALALVAAGVAVLLVLRSNLHDQAELRAEVNARRIATELSNGIPLADLDLPDDNPTVVRDDRDRMVLESEDLGRITGAGDGPTEPPRDARTESPPPSPAPTPTQTPTQTQTSTPSPTGDSDDSDDPEDSGDSGDDNGGDRDDADDDAEDAAEDAEDEANSDDSDDSGNDSAGDSGDDDPAPRRGEVEDEAERHTGTAVLDGERADYRFAGLKVTTPDGQTYTVWAGVPLDTEQNAVGTVGRAMLAGLVPLLAVVAGVTWLVTRRALRPVEGIRGEMAAITASTDLSRRVPEPASRDEVARLARTTNETLTALEESVERQRRFVADASHELRSPIASLRTQLEVAAAHPELLDLDGAVADTVRLQHLAADLLLLARLDAGEEPLGKPVALGALVRETVERRHAEGRESAGPGREAAVVTGELADATVAGSRGQLERVLGNLLNNAVRHAAGRVDVSVRREGAWAVLDVADDGAGVPPADRERIFERFVRLDDARSRDEGGAGLGLAIVRDVVVRHGGTIGVGEAAGGGALFTVRLPLSGPPAGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N654</accession>
    <name>A0A0F7N654_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">LuxR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_16515</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_16515"/>
    <dbReference type="EnsemblBacteria" id="AKH83546">
        <property type="protein sequence ID" value="AKH83546"/>
        <property type="gene ID" value="AA958_16515"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_16515"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3476"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
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            <position position="35"/>
        </location>
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        <source>
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        </source>
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    </evidence>
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        <source>
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</entry>
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">CNQ-509</strain>
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    </feature>
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</entry>
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                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </location>
    </feature>
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        </source>
    </evidence>
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    </evidence>
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</entry>
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                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
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            <begin position="80"/>
            <end position="105"/>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
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    </evidence>
    <sequence length="151" mass="15978" checksum="E669B60CEB0CB252" modified="2015-07-22" version="1">MSMWWSLRLRREAASVPLARRLLVGVMETAGVDPDVAFDLSLALTEACANAVEHGGAAPGEDYRVTACFDGDRCHIEVIDSGPGFATPDPAPGSPAPSPPLTDTGAEGGRGLFLIAELSDHVDIRDRPGRGAVVSFDKILKWREDAPLQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-10-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N802</accession>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </reference>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="86" mass="8220" checksum="CE8004544FC60FC9" modified="2015-07-22" version="1">MLGGGEHPGDRCSHRLPGCPGRPHPLARGAAPEGDPEAVDALSGQCSGATAGTADRAGSGAGTGAGGSASSCPRRTAAGYPLRLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N822</accession>
    <name>A0A0F7N822_9ACTN</name>
    <protein>
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    <organism evidence="1 2">
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_027746122.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH83583">
        <property type="protein sequence ID" value="AKH83583"/>
        <property type="gene ID" value="AA958_16735"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_16735"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3521"/>
    <dbReference type="OrthoDB" id="2050929at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH83583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="66" mass="7711" checksum="D56C30353767D534" modified="2015-07-22" version="1">MAATIGFRPTDEDERIIRAAMREGERTSDVIRRALRLLEHEVWLAQAREDAERLKDEDLSAEEDAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N836</accession>
    <name>A0A0F7N836_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HxlR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_16825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016902.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH83598">
        <property type="protein sequence ID" value="AKH83598"/>
        <property type="gene ID" value="AA958_16825"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_16825"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3540"/>
    <dbReference type="OrthoDB" id="2057904at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="1">
        <location>
            <begin position="12"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="116" mass="12774" checksum="9F8EDA596EDABD90" modified="2015-07-22" version="1">MTRKLAQNTNVCGVTAAIAVIDGKWKTTLLWLLETRPHRPGELVRRLPGLTEKVLTQALREMEGDGLVHREVHEGLPLKTVYSLTDFGRDLSVALAPLSDWGHRRLDNLTGAAAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8A2</accession>
    <name>A0A0F7N8A2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_17350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016987.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_17350"/>
    <dbReference type="EnsemblBacteria" id="AKH83683">
        <property type="protein sequence ID" value="AKH83683"/>
        <property type="gene ID" value="AA958_17350"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_17350"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3649"/>
    <dbReference type="OrthoDB" id="710201at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH83683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="426" mass="46749" checksum="AEEEF63CFCE98B93" modified="2015-07-22" version="1">MLMPLHPNQALQQAIEKSGYTQDDLAEAINEEHEKLYGSPGRCSDRQVRRLLTGEVAWPRDATRLPLEAVLGRRAVELGFRSPPQAALRGRTVRAPAPVDEELPVRRRRFVLSAGTLVALPVLPEAGRIDMSDIARIRGAEARLVQLDDRHGSAELAGVAGRYVAHVAHTMRHCSYGSRVQTALHQALGEMCAQAGWLAYDSQQHEQARRHWRGALQYARLAKSSDLEARVWSCMSRQAVDLGHGSEAVAIARAALDATRGRREPRLSALLHTRVALGHSVTGQRGRCGQSLHRAEQELDRASPQPPPWLAFCGPAELTGQAALCHYNLGDFTDALQADREARTLMGVGEFRRNAFATHVSLARNALAAGEPEEALAAGHRALDLLPEVRSPRWTAHLRGFGRSLGQRGSSPVTAEFLERYRKVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8C4</accession>
    <name>A0A0F7N8C4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">50S ribosomal protein L14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rplN</name>
        <name evidence="6" type="ORF">AA958_21225</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 5">Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the universal ribosomal protein uL14 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018834838.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_21225"/>
    <dbReference type="EnsemblBacteria" id="AKH84296">
        <property type="protein sequence ID" value="AKH84296"/>
        <property type="gene ID" value="AA958_21225"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_21225"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4470"/>
    <dbReference type="OrthoDB" id="1799923at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.150.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01367">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036853">
        <property type="entry name" value="Ribosomal_L14_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000218">
        <property type="entry name" value="Ribosomal_L14P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005745">
        <property type="entry name" value="Ribosomal_L14P_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019972">
        <property type="entry name" value="Ribosomal_L14P_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761">
        <property type="entry name" value="PTHR11761"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00238">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01374">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50193">
        <property type="entry name" value="SSF50193"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01067">
        <property type="entry name" value="rplN_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00049">
        <property type="entry name" value="RIBOSOMAL_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH84296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="122" mass="13301" checksum="0786F67B6B34A491" modified="2015-07-22" version="1">MIQQESRLKVADNTGAKEILCIRVLGGSGRRYAGIGDVVVATVKDAIPGGNVKKGDVVKAVVVRTVKERRRPDGSYIRFDENAAVILKADGDPRGTRIFGPVGRELREKRFMKIISLAPEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8F6</accession>
    <name>A0A0F7N8F6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dimethylmenaquinone methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_13160</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016354.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_13160"/>
    <dbReference type="EnsemblBacteria" id="AKH83022">
        <property type="protein sequence ID" value="AKH83022"/>
        <property type="gene ID" value="AA958_13160"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_13160"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2769"/>
    <dbReference type="OrthoDB" id="1034540at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-linked_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13183">
        <property type="entry name" value="Fer4_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="SSF55103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="2">
        <location>
            <begin position="49"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH83022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="1000" mass="104737" checksum="B8A98BE3BD5BF054" modified="2015-07-22" version="1">MDTETGADAGTDTGVDVVALERRLRDAVGGEVGFGTRDRALVTMDASNYRSVPLGVVAPRDADDVAAALAVCREHGAPVVARGGGTSIAGNAVGAGVVLDFTRHLNRLVDLDPGARTAVVQPGLVLDRLRGAAAPHGLTFGPDPSTHSRCTLGGMVGNNSCGPHSVAWGTMADNVRALDVVTYRGRALRLERDPGVLPGLREFVEGHLATLRTGGRAVGRADGQAPEHAGGLRDKGGAPGADAGAPAPYPRDLPGWPDLPRRISGYALDALLPERGGDLARAFTGSEGTLAVLTQATVRLVEAPPARALAVLGYADESAAAEAAPGLLPLRPLTVEGMAADLVPDAHALPRGGAWLFVETGGDTPAAARAAAEEVCRAADTVDHTVVAEPAEQRVLWRIREDASGTATRMPDGSEAWPGWEDCAVPPARLGAYLREFRALLAAHGLRGLPYGHFGDGCIHVRIDFDLLTAPGIGRFREFSAEMADLVVAHGGSLSGEHGDGRARSELLPAMYGDELVGLFGGFKDLWDPDGALNPGVIARPAPLDADLRFAPLPRVPVPVAFGYPHDGPGGGDFAAAVRRCVGVAKCRDPAGSPGVMCPSYRATGEERHSTRGRARLLHEMLAGEVITDGWRSEEVREALDLCLSCKGCRSDCPVDVDMATYKAEFLHHHYAGRRRPMAHYAMGRLPQWLRLTAALRAAGVANALAAVGPLAAVAKRAAGLAGERAIPPIARVPLTRSLRRDADADPDVLLWPDTFTNYLSPEAGTAAVRVLRAAGLRVGLPREAGKVCCGLTYVSTGQLDQAREAMRRTLDALEPADGGSDDADEGAAGPPLVVLEPPCAAALKTDLVELLPDDERAPRLAARVRTLAEALETAAPDWTPPRLDRPVTGQTHCHQHAVLGDGAERRLMAKAGLEGRLASGCCGLAGNFGFERGHYEVSAACAEDQLLPAVRNAPEDAAVVADGYSCRTQLAQLAGVRARHLAELLAEGLPEEGERDGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8R9</accession>
    <name>A0A0F7N8R9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypoxic response protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_13810</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016461.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_13810"/>
    <dbReference type="EnsemblBacteria" id="AKH83132">
        <property type="protein sequence ID" value="AKH83132"/>
        <property type="gene ID" value="AA958_13810"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_13810"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2908"/>
    <dbReference type="OrthoDB" id="2014094at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="14"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="75"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH83132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="147" mass="15793" checksum="5B596EB0B53F0D48" modified="2015-07-22" version="1">MTAPTTARTARDLMHEGCECIDSTESVATAAAKMRSMDVGCLPVCGQDGKIAGMITDRDIVVECVAQGRDITTCMTGELAEGRPVYVEAGAPVDEVLRAMEQHQVRRLPVIENHQLVGMISEADLSRALSDEQMAAFCRSVYAGGHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8W4</accession>
    <name>A0A0F7N8W4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_19085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017243.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_19085"/>
    <dbReference type="EnsemblBacteria" id="AKH83948">
        <property type="protein sequence ID" value="AKH83948"/>
        <property type="gene ID" value="AA958_19085"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_19085"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4011"/>
    <dbReference type="OrthoDB" id="960478at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005523">
        <property type="entry name" value="DUF317"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03771">
        <property type="entry name" value="SPDY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SPDY" evidence="1">
        <location>
            <begin position="79"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="SPDY" evidence="1">
        <location>
            <begin position="204"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="271" mass="29144" checksum="EBF24B57F66E48B3" modified="2015-07-22" version="1">MEAPLYSGFPLDPSDSTSGQRAYWVGPRHLAGDDGRLYDTVADALGGLGWTSLTIVRGRQEPDEEPEDRQVIRSTVLHISPDSRCWAQWCLADEPFHLGDLPIAWQVSARTDTSSPAEWSAYFTGDVPGEAVADFLTALDARPHPAVPHVRPEVVLDAVTAHGWLRDVDQSAGATDPTFISHVSLGEVPPLIQDADPRTLTAGSDEPAPDGWQSWAQPAPGAPCLWTVSFSASVPHDLVAAFAASLSSTASVLRRVVPEATRERLLWTPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9H7</accession>
    <name>A0A0F7N9H7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Drug:proton antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_20570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017470.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_20570"/>
    <dbReference type="EnsemblBacteria" id="AKH84183">
        <property type="protein sequence ID" value="AKH84183"/>
        <property type="gene ID" value="AA958_20570"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_20570"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4339"/>
    <dbReference type="OrthoDB" id="1770293at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011777">
        <property type="entry name" value="Geranylgeranyl_Rdtase_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02032">
        <property type="entry name" value="GG-red-SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="11"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="428" mass="46858" checksum="9526EF56B890B80E" modified="2015-07-22" version="1">MTDASESTRTADVIVVGAGPAGSTTAYYLAKAGLDVLLLEKTAFPREKVCGDGLTPRATKQLLAMGIDVSEEAGWLRNKGLRIIAGGNRLQLDWPELAAYPDYGLVRKRDDFDQQLAQQAQKAGARLYERCNVGRPVIDERTGRITGVHAKLGEEKTPVTFHAPLVIAADGNSSRLSLAMGLHRNEKRPMGVAVRTYFTSPRHEDDYLESWLELWDKRGAEDRLLPGYGWVFGMGDGTSNVGLGILNSSSAFKELDWRDVLKAWCSSMPEEWGYTPDNMTGPIRGAALPMAFNRQPHYDRGLLLVGDAGGMVNPFNGEGIAYAMESGQIVADVVVQAHGRSTPAQRELALQRYPKVLKDTYGGYYQLGRAFVRLIGNPKVMKLATERGLTHPVLMRFTLKLLANLTDPQGGDAMDRIINGLAKVAPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9S6</accession>
    <name>A0A0F7N9S6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_27225</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018545.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_27225"/>
    <dbReference type="EnsemblBacteria" id="AKH85310">
        <property type="protein sequence ID" value="AKH85310"/>
        <property type="gene ID" value="AA958_27225"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_27225"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5736"/>
    <dbReference type="OrthoDB" id="1209997at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH85310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="270" mass="27834" checksum="85C3854E14D186B8" modified="2015-07-22" version="1">MTGLLLRDKNAVIYGGGGAIGGAIARVFAREGARVFIAGRTQAKLDAVARDITAAGGTVRAAKVDVLDEQAVEKHADEIAATVGGIDIALNAVSVMHDQGTLLADLSLEEFMRPVDGFLRTLFITSKAVARHMGHERPGVILTLSEPGSKLAVGGILGHSVSAAGKEAFSRVLAAELAPSNIRVICIRPHAVVDAPEAGSYTKELFEQTAAAAGQSVQELLEDGAMAQMTLLKRLPTLSEIAETAAFLASDRAGAMTGAIANLSAGALVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NA89</accession>
    <name>A0A0F7NA89_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cobalamin (Vitamin B12) biosynthesis CbiX protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_28150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018699.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_28150"/>
    <dbReference type="EnsemblBacteria" id="AKH85465">
        <property type="protein sequence ID" value="AKH85465"/>
        <property type="gene ID" value="AA958_28150"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_28150"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5934"/>
    <dbReference type="OrthoDB" id="1573073at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002762">
        <property type="entry name" value="CbiX-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01903">
        <property type="entry name" value="CbiX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH85465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="251" mass="26311" checksum="34342D927C9E6D1C" modified="2015-07-22" version="1">MHPVLLIVAHGSRDPRHAATVAALAARVAAARPHARVETCYLDHCAPRVPRALRRLYDEGVRDVVALPLLLARAFHAKSDIPVVLDEVRAALPRLRVVQGGVLGPDALLTAALDRRMAAAGLHLPAERARTGVVLAAAGSSDPEAIASVAETAGEWRRTAGWCAVRPAFASAAPPRTADAVRALRADGAERVAVAPYVIAPGFLPDRIVRGATEARADVLAPVLGAAPELALLLARRYDEACATQPLPLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAA8</accession>
    <name>A0A0F7NAA8_9ACTN</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_25345</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018237.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH84986">
        <property type="protein sequence ID" value="AKH84986"/>
        <property type="gene ID" value="AA958_25345"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_25345"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5341"/>
    <dbReference type="OrthoDB" id="571864at2"/>
    <dbReference type="Proteomes" id="UP000034283">
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    </dbReference>
    <dbReference type="InterPro" id="IPR018721">
        <property type="entry name" value="DUF2252"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR39441">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10009">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH84986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="442" mass="48064" checksum="00B1748ADD89C037" modified="2015-07-22" version="1">MVTDTRDAQRGEEILAVFDSAFGELLAADPAAFRLKFRKMAASAFAFYRGTAALYYHDLEAGERGDPFLTEQTSRVWIHGDLHAENFGTYMDANGRLVFNVNDFDEAFVGPFTWDVKRLAGSLALIGYTKALSDGQITGLVRAYADAYRERIRALAAGAKDDEVPPFTLDTATGPLLGALRTARAHTRFGLLESMTEVRDFERRFTSGGGAIELDAATRARVLDAFEGYLETLPSGGRERRPDAYRVKDVVGRRGIGIGSAGLPSYNILLEGHSDALENDIVIYMKRGQTPAVARHVTDPAIRGYFHHEGHRTVISQRALQAASDPWLGWTELDGAGQLVAEVSPYAVDLDWSDIDDPEQAAAVVGDLGRATATMHAAADVAESGHSLVPFSTEQAIDGAISADADGFTEMLVDFAHDYGARARADHQIFVDLFRNGRISGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAF0</accession>
    <name>A0A0F7NAF0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PucR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_25585</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018281.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_25585"/>
    <dbReference type="EnsemblBacteria" id="AKH85031">
        <property type="protein sequence ID" value="AKH85031"/>
        <property type="gene ID" value="AA958_25585"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_25585"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5394"/>
    <dbReference type="OrthoDB" id="1452079at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
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        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_30" evidence="2">
        <location>
            <begin position="382"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH85031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="443" mass="44483" checksum="3BD67A073399254F" modified="2015-07-22" version="1">MRGDYQQLVDEVSAALGAPATLEDRDFGLIAFGVHDTGDGSSGGVSSLMDPVRTKSILHRRSTAAVRAWFEAYGIARATGPLRIPPDPSAGVLTGRICLPARHDGVVQGYVWLLDDGHLSDVELGGPGRAQDPRIAQAMRTAARIGALLAAETRAGAAAGALLHDVLAGPAAGRDAALAELRDALPGGAAGPVAAVAVLPWRPADPAAPGPGLPRTAATTLVRVGGGTGGGAGPVRALAALVLLPSAGSVDPAVAAAERLLHAAGGGPPGGTRAGAPGEVPAGVRRGARGAARTRAGEPAAGEGAAGVPDAVAGVGDGRADLAGLPGTWREALAAARAARAAPRLGPVARWPEIGPYRLLTDLPGGADPVVGRLLEPAHAALARTAEVYLDHAGQAARTAAALGIHRQTLYYRLSRVEELTGLDLSAGEDRLLLHMSLKSARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAL0</accession>
    <name>A0A0F7NAL0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_17700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_17700"/>
    <dbReference type="EnsemblBacteria" id="AKH83737">
        <property type="protein sequence ID" value="AKH83737"/>
        <property type="gene ID" value="AA958_17700"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_17700"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3727"/>
    <dbReference type="OrthoDB" id="1950284at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024486">
        <property type="entry name" value="DUF2617"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10936">
        <property type="entry name" value="DUF2617"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH83737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="172" mass="18548" checksum="7EDED83EB0F0A865" modified="2015-07-22" version="1">MLTTLKTSYTDTRAQDLAWRLGMEPMPALAVLDLRLGTADVQLRLLGASHQVLLSDGDSACSETVACLPGSNTPLPLGVAKQVAGWEYEFAARVETLTRGAFESRAQELLALVADHPRGLAGTFPGSPHAFTALLVHRQGDVVGWRTWHSYPQEGRLVATRTTMAARVAEPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAS9</accession>
    <name>A0A0F7NAS9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_26450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_26450"/>
    <dbReference type="EnsemblBacteria" id="AKH85181">
        <property type="protein sequence ID" value="AKH85181"/>
        <property type="gene ID" value="AA958_26450"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_26450"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5566"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13492">
        <property type="entry name" value="GAF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="2">
        <location>
            <begin position="89"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH85181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="814" mass="87161" checksum="B5EB8D889FFBE7A5" modified="2015-07-22" version="1">MADAVRVEVADRHAERELPLHSPQLQATPLDREGGRGLMLCAALASRWGVDYTAEHKRVWFQLSVAEPPAGTRAAGPELPVDELPLAEERIRVAVVRIDRGGLVSEWNDDAHDLFGYEPEKVIGKPLGDLAAWPHTPGTGTGLVEALQLSRWEGSYGIRCNDGRVTPVYASHMRLRDSAGDPSTICLMVRDRERAILQTPLRAPAGDSAGSEGHAGGFPGGNSFEAFIGTPSPDDLDGLLQRTVERARDMLAGDAAYLLLATDDETELEVRASTGLPSARQRFARVPVETGTGRYGSARLPSVHEDLMADPDAVPLLAATGMRSVVSVPLKVEGRLTGSLGVAAEMPGRYTNEEALRLQFAADRIALAVESARLGELERLRRGSLSFLVEASDLLAGTLDRDQTLALMAQMIVPTLATWCAVYTLPEQAEPELSYVLHEDEDRIDDLRALLSRIDPPDAVLVPGARLWRGPGDAAHTLAMRSSFLSLSIAGNTTLAEDAETSLATAATVGGETVVLPLVARNRVIGMLVLGKPTDEHFRQEILELAEDLSRRAALALDNARLYSERTTISQSLQRSLLPPGLPDIPGVEVEVIYRPAGEGNEVGGDFYDLFEIRDGTYGFAIGDVCGTGPEAAAVTGLARTALRLLAREGFGGPAVLERLNAAILDEGARGRFLTLLYGELWPQPDGSAVLKTVCAGHPPPLRLRPDGTVEQATESQPLLGVLDDLELHSEELVLDPGDVLLCVTDGVTERREGTRMLGDEGLVDVLTTCTGLTAGAVAARVLRTVERFAAEPASDDMAILAMRVPGQMNGNGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAY4</accession>
    <name>A0A0F7NAY4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_18305</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017136.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_18305"/>
    <dbReference type="EnsemblBacteria" id="AKH83837">
        <property type="protein sequence ID" value="AKH83837"/>
        <property type="gene ID" value="AA958_18305"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_18305"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3847"/>
    <dbReference type="OrthoDB" id="1268974at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH83837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="128" mass="14317" checksum="82E931F3E01FBB47" modified="2015-07-22" version="1">MDRDWADPVLDLDAVARHAGYSRFHFIRAFKAAYGETPGQYLTRRRLERAEHLLRTCNLSVTEVCHMVGFSALGTFSASFKRRTGLSPTAYRDAHVGRGTALIPGCFALLWAGGFDPRIRERNSEEAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NB72</accession>
    <name>A0A0F7NB72_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_23680</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017964.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_23680"/>
    <dbReference type="EnsemblBacteria" id="AKH84709">
        <property type="protein sequence ID" value="AKH84709"/>
        <property type="gene ID" value="AA958_23680"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_23680"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4991"/>
    <dbReference type="OrthoDB" id="1510342at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="141"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="70"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH84709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="276" mass="31065" checksum="7011B67D91916987" modified="2015-07-22" version="1">MRRSLFGRFWPNATAVVLFVIFLFPVYWMFATSLKPTGDIISEDPVWFPLDPTFEHYRTAFDADNFWNFWKNSLTVTLLAVGFSLLVALLASFAIARMRFRGRTGLILVFMFAQMAPWEVMVISVYMLVRDADMLNSLVPLTLFYTVMVLPLTILTLRNFVAAVPKDLEEAAMVDGATRVQAFRKVIFPLLAPGLMATSLFGFITAWNEFPMVLVLNKEAEAQTLPLWLSQFQTQFGDDWGATMAAASLFALPILLLFLYLQRKVTAGLTAGAVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NB95</accession>
    <name>A0A0F7NB95_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_27585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018605.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH85371">
        <property type="protein sequence ID" value="AKH85371"/>
        <property type="gene ID" value="AA958_27585"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_27585"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5813"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="79" mass="8805" checksum="4D9B1AB27873FD82" modified="2015-07-22" version="1">MVRLPRLRRSHNSSPGRGNGNEPAAPAGNRFRSPAEEIQLQAVQVEVLIGVLVHAHHEFVLALRLVQRLPRERLVVQGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBD9</accession>
    <name>A0A0F7NBD9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_27910</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018660.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_27910"/>
    <dbReference type="EnsemblBacteria" id="AKH85426">
        <property type="protein sequence ID" value="AKH85426"/>
        <property type="gene ID" value="AA958_27910"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_27910"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5883"/>
    <dbReference type="OrthoDB" id="607330at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005654">
        <property type="entry name" value="ATPase_AFG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12169">
        <property type="entry name" value="PTHR12169"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03969">
        <property type="entry name" value="AFG1_ATPase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="356"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="370"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH85426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="384" mass="40552" checksum="C28796229BAB03CF" modified="2015-07-22" version="1">MSPSASASIADTPGGIAPGVLTGREPRVPAERLVAELVPPPRFDAVRFSTYVPDPARPSQAEAVRALAAFAAGLGGGATAVGGRRPWWRRAPKEPAGPRGVYLDGGFGVGKTHLLASLWHATEAAPELKGFCTFVELTNLVGALGFQQTVRTLGDHRLLCIDEFELDDPGDTVLVSSLLGKLVDSGVALAATSNTLPGKLGEGRFAAADFLREIQGLADRFRPLRIDGEDYRHRGLPAAPAPLTDEAVGRAAHTVPGATLDAFPDLLGHLARVHPSRYGALTDGVRTVCLTGVRPVADEATALRLVVLADRLYDREIPVLASGVPFDRLFGDDMLAGGYRKKYFRAISRLTALARDARSDVEKRDSTDDSAAVGGSSGTLPPQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBU5</accession>
    <name>A0A0F7NBU5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Acetyl-CoA acetyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_24995</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.9" evidence="7"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018174.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_24995"/>
    <dbReference type="EnsemblBacteria" id="AKH84923">
        <property type="protein sequence ID" value="AKH84923"/>
        <property type="gene ID" value="AA958_24995"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_24995"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5267"/>
    <dbReference type="OrthoDB" id="1058688at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003985">
        <property type="term" value="F:acetyl-CoA C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="5">
        <location>
            <begin position="12"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="6">
        <location>
            <begin position="278"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="3">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="356"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH84923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="402" mass="40741" checksum="80F939C27D0024BA" modified="2015-07-22" version="1">MTGSGTSGTTSVIVAGARTPMGRLLGSLRAFSGADLGGFAIEAALARAGVAADQVEYVIMGQVLQAGAGQIPARQAAVKAGIPMTVPALTVNKVCLSGLDAIALADQLIRAGEFDIVVAGGQESMTNAPHVLPKSREGVKYGALQMLDSMAHDGLTDSFEGIAMGESTEKHNARLGIAREPQDAFAAASHQRAAAARERGIFAEEITPVELPARRGAAVVVDTDEGIRPDTTAEGLAKLRPAFAPDGTITAGTASQISDGAAAVVVMSRAKAEELGLTWLAEIGAHGNVAGPDNSLQSQPSNAILHALKKEGIDVGDLDLIEINEAFAAVAVQSMKDLGVTPEKVNVNGGAIALGHPIGMSGARLVLHLALELKRRGGGTGAAALCGGGGQGDALVVRVPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NC02</accession>
    <name>A0A0F7NC02_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AA958_25250</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018219.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_25250"/>
    <dbReference type="EnsemblBacteria" id="AKH84968">
        <property type="protein sequence ID" value="AKH84968"/>
        <property type="gene ID" value="AA958_25250"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_25250"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5321"/>
    <dbReference type="OrthoDB" id="643917at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="57"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="167"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="197"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="277"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="60"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="400"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="437"/>
            <end position="444"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AKH84968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="658" mass="69407" checksum="EBFAA013B500FE28" modified="2015-07-22" version="1">MPAADIRTEEPEPADSPTAAGTGPGLAGPPAGGEEDRSAVRSLLRLWPYVRPVRVRLFSAAGVAIVASCIGLVIPLVLKWLVDGPVADRDSAGVWLGGLLILALGVAEAALFGFRRWLVARPLAGVEAAMRASLYRHLQRLPVSFHDRWASGQLLSRGTTDLQLIRMFLAFPLTFLVVNGTTIAVGCAVLLAQEWTLGLVLLAPVIPLVALCSAFERRFFGAARRAQDQVGDLTTVVEEAVLGIRIVKGFGRHRSQAQAFRRLTHELRGTELHKARLLAGIWALIMTLPELAIGAALVLGTVQVADGDLSAGTLVAFLSTAMALRWPVESIGFLLAMCNEAATAADRYFEVLDEPEADAADRKAAAAPAGPPVPAAPAVPAVPAVPAQRTGPPPEAADGIRFTGVVFRHPDAGPGTAPVLDGVDLHVRSGETLALVGATGCGKTTLTALVPRLYEPTAGRISLDARDITALPRDELRALVAVAFEEPTLFSATAGENVLMGSYEAEEHDLLRALDIAQADFVHRLPDGHRTEVGEQGLSLSGGQRQRLALARAIVGRPRFLVLDDPLSALDVHTEALVEAALRRVLATTTALVVAHRPSTVLLADRVALLSGGRIAAVGTHDELLHGSAEYRALMAGVPEERTDGAAGAAHGDEGERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NC68</accession>
    <name>A0A0F7NC68_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NADH dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_30450</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the complex I subunit 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019049.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_30450"/>
    <dbReference type="EnsemblBacteria" id="AKH85821">
        <property type="protein sequence ID" value="AKH85821"/>
        <property type="gene ID" value="AA958_30450"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_30450"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6435"/>
    <dbReference type="OrthoDB" id="1559067at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001694">
        <property type="entry name" value="NADH_UbQ_OxRdtase_su1/FPO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11432">
        <property type="entry name" value="PTHR11432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00146">
        <property type="entry name" value="NADHdh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="175"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="255"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="285"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH85821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="311" mass="32623" checksum="609632FC2F6537F9" modified="2015-07-22" version="1">MADTAPVWAVVLLPFALAAAAALVAGFDAVLAAAAGGGRRGRPLRAAPAPLRAGLRLLGQQPRRTTVDDPWLGRMGIALVPVSAVLAGAVLPWGFRAVTDPVVGVVWFNAMEALAWAAVWMAGWGPNSALSLIGGYRFLAQGLAYELPHMFALTTAALGAESLRVGEVVAAQRGLWFAVWMPAAFAVFLLSALAMAFWGPFDHPLGRDAAGGAAAEYAGVDRLVLLAGRWLLLVVTAGFSVPLFLGGGHGPWLPAWAWTLLKTAAVLGLLVAGRRLLPTLRMERYVEFALMVLVPVTLLQALAVAVVVLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCR8</accession>
    <name>A0A0F7NCR8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AbaA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_31515</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019224.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_31515"/>
    <dbReference type="EnsemblBacteria" id="AKH85996">
        <property type="protein sequence ID" value="AKH85996"/>
        <property type="gene ID" value="AA958_31515"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_31515"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6657"/>
    <dbReference type="OrthoDB" id="1903180at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="2">
        <location>
            <begin position="21"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH85996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="82" mass="8727" checksum="4DB2B0B154A9A0EC" modified="2015-07-22" version="1">MRADPPTFQSGIPATELGTEGWQKPWSGTNGGSCVEAKRLPDGSVALRQSTDPTGPALVYTREEMVAFLQGAKDGQADYLVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCT2</accession>
    <name>A0A0F7NCT2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carbon monoxide dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_31610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019239.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_31610"/>
    <dbReference type="EnsemblBacteria" id="AKH86011">
        <property type="protein sequence ID" value="AKH86011"/>
        <property type="gene ID" value="AA958_31610"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_31610"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6676"/>
    <dbReference type="OrthoDB" id="1843415at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002888">
        <property type="entry name" value="2Fe-2S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036884">
        <property type="entry name" value="2Fe-2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01799">
        <property type="entry name" value="Fer2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47741">
        <property type="entry name" value="SSF47741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="2">
        <location>
            <begin position="2"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH86011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="170" mass="17623" checksum="E28821F64856507D" modified="2015-07-22" version="1">MSRISVTVDGTTYEDDVEPRLLLVHYLRDRLGLTGTPVGCDTGNCGACTVDVAGASVKSCSMLAVQADGTEVTTIQGLAGDGRWHPLQRAFHEEHGLQCGYCTPGMILAARDLLRANPHPTAEEVRHGLEGNLCRCTGYQNIVRAVLAAAEAGAGTGTDAGAGDGGEAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCT6</accession>
    <name>A0A0F7NCT6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ROK family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_31640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ROK (NagC/XylR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019244.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_31640"/>
    <dbReference type="EnsemblBacteria" id="AKH86016">
        <property type="protein sequence ID" value="AKH86016"/>
        <property type="gene ID" value="AA958_31640"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_31640"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6682"/>
    <dbReference type="OrthoDB" id="1130699at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="412" mass="42278" checksum="340E4262F33A7DE4" modified="2015-07-22" version="1">MAANPASAGRLLRLIRSGEAPTRAELQRATGLSRSTVGLRLDQLFRAGWIREVAGTSTGGRPSARLEFDDRHAVVLAADLETRHGRAAVLDLAGNLLAEKTGPLVIGDGPEPVLAEVCRWFGPLLAEAGESAARVCGIGLSVPGPVDVAAGRVVEPPIMPGWDGYPLTGHLRRTFAARLGGAPDVPVFVDNDANLMAYGEQRAGFPDCAAFLLVKASTGIGAGVVVDGGVYRGIDGGAGDIGHIRLHDSREALCTCGSYGCLAAVASGHALAARLDGLGVPAASGSDVRDLLAAGHPQAVRLAREAGQRVGEVLVTVVTLLNPGVLMIAGELSSVPFLTGVRELLYRRAMPRTTAHLDVVTARLGDRSALVGAAAMVVDELYAPDRADARLAAADAAAPEPGAGDLAADHPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCV0</accession>
    <name>A0A0F7NCV0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_31745</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019259.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_31745"/>
    <dbReference type="EnsemblBacteria" id="AKH86031">
        <property type="protein sequence ID" value="AKH86031"/>
        <property type="gene ID" value="AA958_31745"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_31745"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6703"/>
    <dbReference type="OrthoDB" id="466142at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EFG_III/V"/>
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        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
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        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="5">
        <location>
            <begin position="1"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH86031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="680" mass="71592" checksum="E89D211391A356FE" modified="2015-07-22" version="1">MHTLNLGILAHVDAGKTSLTERLLHAAGVVEEVGSVDDGSTRTDSLALERQRGITIKSAVVSFALDGLTVNLIDTPGHPDFIAEVERVLHVLDGAVLVVSAVEGVQAQTRVLMRTLRRLSIPTLVFVNKTDRRGARDDALVRDIAAKLTPGAVAMGSVRGLGTRAAAFTPYGPDHPGGPGDPGNAAFAGRLADLLSRRDDALLADYVADEAAVTYRRLRKSLAEQTAGALVHPVFFGSAATGAGVAELTAGIKELLPAPAGDPEGPPAGTVFKVERGPGGEKAAYVRMLAGTLRTRQEVAYGDGDRAPVTEKVTGVEVFEQGAAVPAAGAGAGRIARVRGLAGVRIGDAVGAAVGRAAEARRHHFAPPTLETVVVPDRPADRGALHAALFQLAEQDPLIALRRGAGPGGLQELYVSLYGEVQKEVVGATLAGEYGLPVSFRESSVIHVERLAGSGSAYEKGDTDTNPFLATVGLRVDPAPPGTGVVFALAVELGSMPYAFFKAVEDTVRATLHQGLSGWEIPDVRVTLTHSGYWPRQSHAHQGFSKAMSSTGADFRGITPLVLADALKRAGTRVHEPVQRFRLEAPEDAVPALWPVFAALAAVVDGQEVRGGVAVLEGEVPAAQVHGLERRLPGLTRGEGVLETSFGRYREVRGPAPARPRTDHNPLDRKEYLLHVQRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCZ6</accession>
    <name>A0A0F7NCZ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Carboxypeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_32080</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019319.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_32080"/>
    <dbReference type="EnsemblBacteria" id="AKH86091">
        <property type="protein sequence ID" value="AKH86091"/>
        <property type="gene ID" value="AA958_32080"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_32080"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6773"/>
    <dbReference type="OrthoDB" id="397741at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519958" evidence="2">
        <location>
            <begin position="36"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M14" evidence="3">
        <location>
            <begin position="51"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH86091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="442" mass="47441" checksum="9F4140B986DF0749" modified="2015-07-22" version="1">MRIRAPRLTVLRTATLAACAAAVVLAPPSGPPAEAANPPRTGFEESGGARWTSEQEEAEFLATVAEDSRRVAVDRIGTTEQGRPLNLVRIGAPRPPTPAEAVRGSVVLLICSQHGDEPAGREACLTSLRDLAYAKDAGTRRFLARNTVLVVPSANPDGRAADTRGNADGVDVNRDHVALETAEGRAMAAVIRDYRPDVVHDLHEFDATEPYYVKDVLALWPRNLNTHDGVHREARHLTEDHVRAGVEEAGYSSGVYGIWTDPQTGEPIRQVAGDGQERILRNAAGLKHAAGLLVETRITALTDEERGDPAANHRRRVTSQLTALDATFTYAADHRGRLATATAAARARGLADTGPVYLGGADNEPPAPGQIIDDPPCGYELDAAQYGAVGDELALHGIEVRERPDGGALVKLRQPLRALVPLLLDQRAVYELADGRPLEHCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7ND29</accession>
    <name>A0A0F7ND29_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD-binding molybdopterin dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_27420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018578.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_27420"/>
    <dbReference type="EnsemblBacteria" id="AKH85344">
        <property type="protein sequence ID" value="AKH85344"/>
        <property type="gene ID" value="AA958_27420"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_27420"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5778"/>
    <dbReference type="OrthoDB" id="1017413at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005107">
        <property type="entry name" value="CO_DH_flav_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036683">
        <property type="entry name" value="CO_DH_flav_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002346">
        <property type="entry name" value="Mopterin_DH_FAD-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03450">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00941">
        <property type="entry name" value="FAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01092">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55447">
        <property type="entry name" value="SSF55447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="327" mass="34375" checksum="ADAEB77E96E02797" modified="2015-07-22" version="1">MKPFDYVRASGPSEAAGLVASRDAAAFIAGGTELTNLMKDGVLAPDLVVDVGGLPLSGVELRGGRLHIGATARMQTVADHPVVRERFPVVSQALLASASPQVRNRATIGGNLMQRTRCGYYRDTGSPCNRRMPGSGCPAIDGQNRRHAILGGSSHCIAVHPSDLAVALTAVDALVLTLGPAGRRSIALADLHLLPGSTPHRETALRRGEIITGVEVPVSPAARTSRYLKLRDRASFEFAVVSVAAALAFRGRVVTDVRLAFGGVAPRPWRSAAAEDALRGRPLTGAAVAAAGRHLVRGAEPREHNRFKVDLVQRALADVLDALGGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-06-17" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7ND33</accession>
    <name>A0A0F7ND33_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_33730</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019592.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86370">
        <property type="protein sequence ID" value="AKH86370"/>
        <property type="gene ID" value="AA958_33730"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_33730"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.7122"/>
    <dbReference type="OrthoDB" id="420505at201174"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="2">
        <location>
            <begin position="3"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="1">
        <location>
            <position position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH86370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="82" mass="8850" checksum="8F97444CE8DF54F7" modified="2015-07-22" version="1">MTSSTRQSAEELLDLLTTEFGATEGSTAETPFDMMEFDSLVLVEVAVELSRRFGTEVPHEEVQEAGNVTGTVELLKSKGVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7ND37</accession>
    <name>A0A0F7ND37_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_23365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017913.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_23365"/>
    <dbReference type="EnsemblBacteria" id="AKH84657">
        <property type="protein sequence ID" value="AKH84657"/>
        <property type="gene ID" value="AA958_23365"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_23365"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4926"/>
    <dbReference type="OrthoDB" id="1414501at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="260" mass="27438" checksum="9233ACF6EDFC21C2" modified="2015-07-22" version="1">METPPADEAAPQDTGDTGGTGDTAAAPAASGVAAEDWAQAAADPQYRAAVVDLLGALAYGELAAFERLAEDAKLAPGVEDKAELAAMAAAEFHHFERLRDRLAGIDEDPARAMEPFAAALNEFHRQTAPSDWLEGLVKAYVGDSIASDFYREVAVRLDSDTRGLVLSVLDDTGHATFAVGKVRSAIEADPRVGGRLALWARRLMGEALSQAQRVVAERDALSMMLVGGVADGFDLAEVGRMFSRITEAHTKRMAALGLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7ND63</accession>
    <name>A0A0F7ND63_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_33905</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019622.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_33905"/>
    <dbReference type="EnsemblBacteria" id="AKH86400">
        <property type="protein sequence ID" value="AKH86400"/>
        <property type="gene ID" value="AA958_33905"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_33905"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.7159"/>
    <dbReference type="OrthoDB" id="1479518at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="126"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="237"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="284"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="91"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH86400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="319" mass="34583" checksum="FC94EA445FE96142" modified="2015-07-22" version="1">MIPTLFGISVVAFAIIQLPPGDFLTTLAARLENQGDRMDEAQMSALRERYGLGEPVYEQYGKWVSAIVLHGDFGESFEYGKSVSSLVMDRLPLTVVLAVSTLLATWLLAFPVGLYSAVRQYSVGDYVATTVGFLGLAIPNFMIALVLMYLGHSVFGMSVGGLYSPEYEDAAWNLGKFLDLLSHLWVPVLVLGAAGTAGLVRVLRANLLDELRKPYVVAARARGMPERRLVLKYPLRVALNPFVSNVGYVLPALVSGEVIVSQVLSLPTTGPLLLGALRSQDMYLASSIILIVSLLTVIGTLLSDVLLAWLDPRVRLAQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDG6</accession>
    <name>A0A0F7NDG6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Adenosine 5'-phosphosulfate reductase</fullName>
            <shortName evidence="3">APS reductase</shortName>
            <ecNumber evidence="3">1.8.4.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">5'-adenylylsulfate reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Thioredoxin-dependent 5'-adenylylsulfate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cysH</name>
        <name evidence="5" type="ORF">AA958_28145</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the formation of sulfite from adenosine 5'-phosphosulfate (APS) using thioredoxin as an electron donor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>[thioredoxin]-disulfide + AMP + 2 H(+) + sulfite = [thioredoxin]-dithiol + adenosine 5'-phosphosulfate</text>
            <dbReference type="Rhea" id="RHEA:21976"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="1.8.4.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="3">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the PAPS reductase family. CysH subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.10" evidence="3"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018698.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_28145"/>
    <dbReference type="EnsemblBacteria" id="AKH85464">
        <property type="protein sequence ID" value="AKH85464"/>
        <property type="gene ID" value="AA958_28145"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_28145"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5933"/>
    <dbReference type="OrthoDB" id="674332at2"/>
    <dbReference type="UniPathway" id="UPA00342"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004604">
        <property type="term" value="F:phosphoadenylyl-sulfate reductase (thioredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019379">
        <property type="term" value="P:sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01713">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00063">
        <property type="entry name" value="CysH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004511">
        <property type="entry name" value="PAPS/APS_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002500">
        <property type="entry name" value="PAPS_reduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01507">
        <property type="entry name" value="PAPS_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000857">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00434">
        <property type="entry name" value="cysH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAPS_reduct" evidence="4">
        <location>
            <begin position="50"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; cysteine thiosulfonate intermediate" evidence="3">
        <location>
            <position position="233"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH85464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="237" mass="25770" checksum="5B8E5C8001269FC0" modified="2015-07-22" version="1">MTVIDDADTDTADTAALAEQAGRELEDAPALEILRWAADTFGKRFCVTSSMQDMVVAHLASRAMPGVDVLFLDTGYHFPETIGTRDAVAAVMDVNVVSLTPRLTVAEQDAEYGPRLYERNPDLCCALRKMQPLEDGLAAYDAWATGLRRDESPTRANTPVVGWDAKRRKVKVSPIARWTEEDVQAYVAEHGVLTNPLLADGYPSIGCAPCTRRVAPGEDARAGRWAGFAKTECGINV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDH3</accession>
    <name>A0A0F7NDH3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_04665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86545">
        <property type="protein sequence ID" value="AKH86545"/>
        <property type="gene ID" value="AA958_04665"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_04665"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.983"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="38"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="314" mass="33224" checksum="3579C04CD62BF6AA" modified="2015-07-22" version="1">MRGLAASAGGAALAAGVGTGTARAAGAGRRRDGVRTYVLVHGTHSAGAFWTEIGRELALRGHRVVAVDQPLHGTERFVPEAYQTQDLAALATEPSPVAALNLDAFEARVTGAVRRAARLGGPVVLVGHSMGGLSVSRVGNAVPELLDHICYMAAFCPSRTMPSLDVCAASPEGQDAISPVEQVVGDPEKLGALRLNWRSANPRDLAVFKEMICANYTDGAFLRVLEGMQTDESLTAYAGRAVGRRHTWGRVPRTYLRFGNDRTVATALQDRMIAEADALTPHNRFTVHDFPDAGHLGPADPAPVTDILHGLPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDI7</accession>
    <name>A0A0F7NDI7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphoglycerate mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_27945</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018667.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_27945"/>
    <dbReference type="EnsemblBacteria" id="AKH85433">
        <property type="protein sequence ID" value="AKH85433"/>
        <property type="gene ID" value="AA958_27945"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_27945"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5890"/>
    <dbReference type="OrthoDB" id="1122642at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH85433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="222" mass="23922" checksum="9E2511DF92FED06B" modified="2015-07-22" version="1">MSLNVIFVRHGESVWHGENRYAGATDIDLTDHGRDQAAALADWAAQAGLTAVWSSPMLRCRQTAAGSAAAAGLPLHLDPRLRELDFGVAEGLTRAEMRERMPEAVASFEADPVASHFPEGEDPAAVVERYVAFLADLRAEHDTGAQGDGKQTGGKESDGRILVVAHSTAIRLTLCRLLDLPLRDYRRRFPHLANCALNELVLSDGTPSLLTLNRPVTPGVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDQ0</accession>
    <name>A0A0F7NDQ0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Malate synthase</fullName>
            <ecNumber evidence="2 7">2.3.3.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_28440</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>acetyl-CoA + glyoxylate + H2O = (S)-malate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18181"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Carbohydrate metabolism; glyoxylate cycle; (S)-malate from isocitrate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the malate synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.9" evidence="2 7"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018752.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_28440"/>
    <dbReference type="EnsemblBacteria" id="AKH85518">
        <property type="protein sequence ID" value="AKH85518"/>
        <property type="gene ID" value="AA958_28440"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_28440"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5993"/>
    <dbReference type="OrthoDB" id="322024at2"/>
    <dbReference type="UniPathway" id="UPA00703">
        <property type="reaction ID" value="UER00720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004474">
        <property type="term" value="F:malate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006097">
        <property type="term" value="P:glyoxylate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00727">
        <property type="entry name" value="malate_synt_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1220.12">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044856">
        <property type="entry name" value="Malate_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011076">
        <property type="entry name" value="Malate_synth_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006252">
        <property type="entry name" value="Malate_synthA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001465">
        <property type="entry name" value="Malate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019830">
        <property type="entry name" value="Malate_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046363">
        <property type="entry name" value="MS_N_TIM-barrel_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42902">
        <property type="entry name" value="PTHR42902"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01274">
        <property type="entry name" value="Malate_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001363">
        <property type="entry name" value="Malate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51645">
        <property type="entry name" value="SSF51645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01344">
        <property type="entry name" value="malate_syn_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00510">
        <property type="entry name" value="MALATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0329">Glyoxylate bypass</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001363-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH85518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="532" mass="59224" checksum="EB0AF96A7134E24D" modified="2015-07-22" version="1">MSAVVAAEPASRQDDVLTDAALAFLGELHRRFTPRRDELLARRAERRAAIARTATLDFLPETAAVRADDTWRVAPAPPALEDRRVEITGPTDRKMTINALNSGARVWLADFEDASAPTWENVIGGQANLIDAYERRIDFTDPASGKSYALRPAAELATVVARPRGWHLDERHVTVDGRPVPGALVDFGLYFFHNARRLLDVGKGPYFYLPKTESHLEARLWNEVFVFAQDYCGIPQGTVRATVLIETITAAYEMEEILYELRDHASGLNAGRWDYLFSIVKNFRDGGAKFVLPDRNAVTMTAPFMRAYTELLVRTCHKRGAHAIGGMAAFIPSRRDPEVNEVAFEKVKADKDREARDGFDGSWVAHPDLVPLALESFDAVLGERPHQKDRLREDVSVAAADLIAVDSLDARPTYPGLVNAVQVGIRYIEAWLRGMGAVAIFNLMEDAATAEISRSQIWQWINAGVVFDDGRRVTEELVRRIAADELADLRAELGAEAFAAGRWQQAHDLLLRVSLDADYADFLTLPAYELLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDW5</accession>
    <name>A0A0F7NDW5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amine oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_24620</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018114.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_24620"/>
    <dbReference type="EnsemblBacteria" id="AKH84862">
        <property type="protein sequence ID" value="AKH84862"/>
        <property type="gene ID" value="AA958_24620"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_24620"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5192"/>
    <dbReference type="OrthoDB" id="630753at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amino_oxidase" evidence="2">
        <location>
            <begin position="18"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="395"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH84862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="416" mass="43991" checksum="4271995B05DEE340" modified="2015-07-22" version="1">MSDEHRRAPDAVVVGAGLAGLACALDLCRARWRVTLLEASDGAGGRMRTDRRDGFLLDRGFQVFNTSYPQVKRRLELSSLRLRPFTAGIIAHTPDGPVRLADPTREPRAAWTLLPGRVLTARDLAAMAALTVRDAVLPVSVTGRRRDRSTSAALSGAGLSDAVIAGILRPFLSGVFLEDRLETSARFFHLVWRSMVRGSLCLPAEGIGAVPAQLAAGLPDGVLRLGTPVEEVTDDGVLLGNGSEVPARVVVVATDPATAARLVPDLTVPDTRTVTTYYHATGRPPAAEPILRVDSTGAVLNTCVLSEVAPTYAPPGTGLISTSVLGTDRPGRAQAVLRRLAELYGTDTGTWEQVAARTVEGALPAMLPPWSLSRTTRLGPGRYVCGDHRATGSVQGALASGTRAAREVRADLGPER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NE62</accession>
    <name>A0A0F7NE62_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_14240</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_027773294.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_14240"/>
    <dbReference type="EnsemblBacteria" id="AKH86755">
        <property type="protein sequence ID" value="AKH86755"/>
        <property type="gene ID" value="AA958_14240"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_14240"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2997"/>
    <dbReference type="OrthoDB" id="1694312at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="173"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="67"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH86755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="269" mass="29695" checksum="50E38BC597B6AD3B" modified="2015-07-22" version="1">MVRARKVWLWLTRRAAFRNLGPFVPVIALWWLVAELGVFDEAFFVGPPRVVEEFGDLMRKGILPGYLTDSLTRLAYGVGFGLAIGLPMGFVVAMFAKVRRFFWPILLFFQAVADIAWLPIVIVWFGFSLTAVTFVIVYTIVFPLMLSVVAGVEQVPRELLRAARSLGAGRVRVFFEVILPGALPSVAGGIRTGLGYGWRALVAAEIIVGTSGVGFMMFDARRVGDISQVFLGMAVLGILWYALDAMVLAPFERATVERWGMVRSLEADG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NE70</accession>
    <name>A0A0F7NE70_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_29455</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018912.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_29455"/>
    <dbReference type="EnsemblBacteria" id="AKH85683">
        <property type="protein sequence ID" value="AKH85683"/>
        <property type="gene ID" value="AA958_29455"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_29455"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6215"/>
    <dbReference type="OrthoDB" id="1108236at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="109"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="236"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="308"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="338"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="362"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="398"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="445"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="19"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH85683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="486" mass="50667" checksum="C1FAE6A8B4549B84" modified="2015-07-22" version="1">MTSAASEPQVRWSAKQRALLAVLCLALLLDGLDVTLVGVALPEIGADLGLDTAQLQWIVNGYLLGYGALLLLGGRTADLVGRRKVFLVALAVFAIASLIGGLVDDGLLIIATRFVKGVAAAFTVPTGLSIITTTFPEGRQRNKAIAIYTAFGASGFSSGLVIGGLMTGLSWRWTFLFSVPIAFGALVVGIFLIPRDRPNARGRYDFLGALTMTAGLLLLVYTVVNAPEVGWGASRTLLSFVGVVVLLAAFVAVERKVDSPLVPLRVFRRGALMRANFSFIALLGSYFSFQFLMTLYLQGTLGWSPLELALALLPIGLIVAFGAPAAGRLIPRFGTAKLIVFGLSAEAIGFILLLRLTTDPAYVSLILPTVVLVGIGFAFVFPCANVQAVTGVEPGEQGLAAGMLQASGQIGAAVVLAVTTAIIAMDGADGAQPSAQEVLDEFRPGLVFATAVALAGVVLVLIKRRTPQPSAASESALAPEADTPAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NEQ8</accession>
    <name>A0A0F7NEQ8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MFS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_31155</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019162.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_31155"/>
    <dbReference type="EnsemblBacteria" id="AKH85934">
        <property type="protein sequence ID" value="AKH85934"/>
        <property type="gene ID" value="AA958_31155"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_31155"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6583"/>
    <dbReference type="OrthoDB" id="1108236at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="267"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="301"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="328"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="359"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="404"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="477"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="11"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH85934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="500" mass="49628" checksum="D677B197FEC286BE" modified="2015-07-22" version="1">MPPPAVGPGRRTAVLTVMCLALAVVVGMLASLLVAVPGMARDLEATEAELQWVMNAYGVTFAGLLLAGGALGDRYGRKGVLLTGLAVFGLASGAVLLIDDVTLVIVLRGVAGVGAALVMPMTLSIITAVHPPESRGRAVGIWSGVSFGSALLAVLLAGGLLEAYSWRSVFAVNAGLAAVALLAAAVLAPASRAASAAPLDVVGALLSVTGIGAVVFGIVEGPERGWVHGSVLGGFAVGAAALGAFVRWELRTPYPLLDLRVLRLPGVSAGSLIITAETLAMFGFFFLGLQYLQEILGYSPIRAGLALVAMAAGAMVFSPVAPALAKRYGMAVVIGLGMALIAAGLLVLAAVVGGSGVRGFLVATAVLGAGVAFAATPATEAIVAALPDGKQGVASALNDLTRELGGVLGIAVLGSVFNSAYRSEVGRAAEGLPDGASDTARDSLAGALRVADGIGGPRGAEFAGAAREAFNSGMSSALVGGLAVVVLGGGVAVTLLRRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NES9</accession>
    <name>A0A0F7NES9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Methyltransf_11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_26735</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018469.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH85232">
        <property type="protein sequence ID" value="AKH85232"/>
        <property type="gene ID" value="AA958_26735"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_26735"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5625"/>
    <dbReference type="OrthoDB" id="1518440at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="2">
        <location>
            <begin position="83"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH85232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="289" mass="31871" checksum="E3ECCED4A787760B" modified="2015-07-22" version="1">MATDAHDSGLAPPSPEEVGSAYDRFGPLYDLTQGTTAIHVGRWSADGAGPPATSLGKLADQAMNRQTDYYIDALAPGETDHVLDIGSGTGGPAVRLAERTGARVTGITVSETQVARSRERAAAASLTDRVTFALNDALELPYEDASFDAAWAIDSFAHIADRLRGLRQAWRVLPRGGRFLMTEFTRRGEPSRAQLDTLRQVWTSPPPLPLAEGVRLAYEAGFELERLENQTHDVIMNAEVMTVLYRDHHDEIRERYGLETTAAMDASIPLFRTFVRDHLGYFVYLLRKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NET6</accession>
    <name>A0A0F7NET6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_31340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019192.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_31340"/>
    <dbReference type="EnsemblBacteria" id="AKH85964">
        <property type="protein sequence ID" value="AKH85964"/>
        <property type="gene ID" value="AA958_31340"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_31340"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6622"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002520019" evidence="1">
        <location>
            <begin position="27"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="397" mass="41870" checksum="0DDC0446F47B16CE" modified="2015-07-22" version="1">MPLKRHLRSLALPLVAGVLLTTAACGDDGDGGAGGKESPAAKSGAGSLAGVCPETVTVQTSWLPNATAFGPLYALLGEDPEVDADRKRATAPLVADGRDTGISLELRAGGPAIGFAATSAEMYTDEDIDLGVVGGFDEIVQLSATQPTTAVLALLEKDPTMIYWDPETYPEFETIEDVGKSDTTVLYSGGDTYMEYLTGAGILRKDQVDGSFDGSPARFVASGGKLASSGYAAEDPYMFEHEIDDWMKPVKGQLVYEAGYPIYGPSLVVRPEAKSELAPCLEKLIPVVQQSQVDYLRDPDAAIAAIVDIAEQYKGGDVLTEGIAQYGIGEMKRLGIASDDAEGEDTTVGNFDTARVREIIDIGEPIFAEQKKPVKDGLKPADVVTNEFLDPAIGHGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NEW2</accession>
    <name>A0A0F7NEW2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptidase_S8 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_31470</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019217.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_31470"/>
    <dbReference type="EnsemblBacteria" id="AKH85989">
        <property type="protein sequence ID" value="AKH85989"/>
        <property type="gene ID" value="AA958_31470"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_31470"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6649"/>
    <dbReference type="OrthoDB" id="923655at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017296">
        <property type="entry name" value="Peptidase_S8A_SAM-P45"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037852">
        <property type="entry name" value="Subtilisin_rel_SAV5721"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519380" description="Peptidase_S8 domain-containing protein" evidence="6">
        <location>
            <begin position="29"/>
            <end position="1271"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S8" evidence="7">
        <location>
            <begin position="231"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH85989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="1271" mass="132790" checksum="43E8B06EA0A09902" modified="2015-07-22" version="1">MHLRRVKLPALATAGALLVTLAPSATHAAASPGGVTVADRAAGPSLSSVTLVTGDRVRLERFPDGRQAATVTPRDGAEGGGGFEQLEIDGDLHVIPTDAVPYVGSGAVDRDLFNITELVEQGYGDGRSKRIPLIVSYAKGARSADAAELPGVRTGPALPSLNARAVEAGKDRADRLWEAVDDDRGNARTAAGPKLAGGIERIWLDRKVSASLDRSVAQIGAPGVWQGGHDGKGVKVAVLDTGVDAEHPDLAGKIDEARNFSDSPTTGDAFGHGTHVAATVAGSGAGSGGSRKGVAPGARLLVGKVLGDDGFGSESQVLAGMEWAAGAGADVVNMSLGTDGATDGTDALSLGLNRLTAQTGTLFVASAGNNGPSSATVGSPGAADAALTVGAVDRDESLAGFSSRGPRVGDLAVKPDITAPGVDIVAARAAGTAMGTPVDDLYTAASGTSMAAPHVAGAAALIAQRHPDWTAQQLKDALVSTAQRHDDLTVYEQGGGRVDAARADAQQVYATGTLGFGGVDEGGEPVRREVTYTNASDAPVTLGLAASLRAANGEPVPADAVGLPDGDTVEIAAGGTATVPVTLDPAGLRPGRYGGYVTATAGDTVVHTTIGAVREAPTRTVTLRGIDRSGQPAFVNPVTLFGEDDRYDVVTYIANGRTLTVEVPEGEYFLHAVVSDKIPGGGVDSLIVDPQLKVDGDLDVVLDARKANEVKIETPKPAVQEAVMSFYSHREFGNRSISHGHMEFSVDGRKLYVTPTARAREGVFEVSSRWQLEAPMLTGTVRGPGTQGRAGIEAVRLMGRSPALDGTRRLPLVDAGAGTEADFAALADDGADLARSAVLVDGESPQDENAVRRAAAAGAKYVIVVCPEDSPGWSVWRPGGERLPAVGAMVRYDVGERLRAASAGGPATVELRGTPASPYMYDVMQVAKQQVPEQVVHRVNSSNTATVETSYGDSGGNPWTKEQRFGWRPWMGTAINQYQRHVPTPHERTEYVSAGDTLWRHNVHHRYTFDTFNPLAGGMIQEARSYRAGERVEESWFAPVVRPAIPRGVEGLTSYREGDQLTIRIPEFADSQKGHYSRLDGGDWDGTPADKSSAALYRDGEKLAEGRTAWGAFPAGGTGGKGTYRLDLAVDRTTPEWRTGVSTRTSWSFAADRPAAGEQDLLPLLQLDYDVATDARGAAPGGRLVPLGITARHQDGLDGRRIKGMEVSTSFDDGATWKDAVAIPWWDGSYQVLLRHPAVGDDGGFVSLRVKAWDDAGNSVEQTVKRAYALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NEZ7</accession>
    <name>A0A0F7NEZ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Daunorubicin resistance protein DrrC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_31760</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019262.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_31760"/>
    <dbReference type="EnsemblBacteria" id="AKH86034">
        <property type="protein sequence ID" value="AKH86034"/>
        <property type="gene ID" value="AA958_31760"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_31760"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6706"/>
    <dbReference type="OrthoDB" id="152379at2"/>
    <dbReference type="Proteomes" id="UP000034283">
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    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
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    </dbReference>
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        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
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    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="134"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="437"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="477"/>
            <end position="484"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH86034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="745" mass="80012" checksum="CD936D5131F2C2F1" modified="2015-07-22" version="1">MIKVRGARANNLAGISLDIPKRRLSVFTGVSGSGKSSLVFGTIAAESQRLINETYSAFVQSFMPNLPRPDADGLHNLSAAIVIDQERMGANSRSTVGTATDAYAMLRILFSRLGEPHVGTSGAFSFNVPEGMCPRCEGLGEVSQIDVDQLVDRRLSLNEGAVTIPNFAVGNWYWEVLVSSGFYDPDKKLADFTDQEWHDLLRKETVKVKVGNHNITYEGLIPKITRMWLVKERDALQGHVRAFVDRAVVFAECPDCGGTRLSAAALSSKIRGRNIAECAALQITDLAKFVRGIEDESVGPLLDNLRGLLDSLVEIGLGYLSLDRPSATLSGGEAQRVKMVRHLGSSLTDVTYVFDEPTAGLHPHDIRRMNDLLLRLRDKGNTVLVVEHKPEVIAIADHVVDLGPGAGGDGGHVTFSGDVPGLRASTTLTGRYLEHRVRLRERPRKPRGHIAVEGADLHNLRDVGVEVPLGVLTVVTGVAGSGKSSLVHGYLAGRDGVVVADQSPIRGSRRSNPATYTGLLGPMRTAFAKANGVKAALFSANSAGACPKCKGIGLIYTDLAMMAGVASVCEECEGRRYTPEVLTYTLRGKNISEVLQMSVAEAHGFFPAGQAHAILGRLADVGLGYLRLGQPLNTLSGGERQRLKLAIHMAEKAATYILDEPTTGLHMADVDKLLALLDRLVDDGNSVVVIEHHQAVMAHADWLIDLGPGGGHDGGRVVFTGTPAALVAEADTLTAQHLREYVDRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NF12</accession>
    <name>A0A0F7NF12_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_31880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019282.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_31880"/>
    <dbReference type="EnsemblBacteria" id="AKH86054">
        <property type="protein sequence ID" value="AKH86054"/>
        <property type="gene ID" value="AA958_31880"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_31880"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6733"/>
    <dbReference type="OrthoDB" id="1196738at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="22"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="267" mass="28385" checksum="002A4A1EF9D961DD" modified="2015-07-22" version="1">MTTARINGITLGFDDHGAGEPVVMVTGTGAPGRIWRTHQVPALTAAGHRVITVDNRGMPPSDPCPEGFTLADMAADTAGLIEHLDLAPCRVVGFSLGASIVQELLLARPELVRQAVLMAPTGRADGLVSAMTAAELDLCDSGVKLPPRYAAYVNALQNLSPQTLNDEATLRDWLDVFELTAVDMSAFRGQLELQTTVDRLGAYPRISRPCLVIGFGDDLVIRPHLSREVAAAIPDAAYVEIPGCGHYGYLERPDAVNAAVLDFFAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NF74</accession>
    <name>A0A0F7NF74_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_32260</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019352.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_32260"/>
    <dbReference type="EnsemblBacteria" id="AKH86124">
        <property type="protein sequence ID" value="AKH86124"/>
        <property type="gene ID" value="AA958_32260"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_32260"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6811"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="3">
        <location>
            <begin position="266"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="381"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="532"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH86124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="562" mass="58678" checksum="B7F6CE1A464DBA33" modified="2015-07-22" version="1">MDPAGPATGGRRTGFVRWWLIPTAVVVVSTAIALPLVSADARTPVAVCGAIATLVVAFAAAEAERRGRAAGAPSAEQADHEAAWERRLAAREAEMIRLAGLLPQAVARLQRGEYAEDVLADIEAEKSLTPQVRAAHAAALRSVVEAVQDAEDLRVSAERGFVNIARRVQAIIHQQARSLREMEDRHGRRHEFFADLLKLDHGTALVGRLADSIAVLGGDRPGRQWGKAIALYSVLRGGMSRIIDYQRVELHPVAEVAVVGSAVEPLIHAVAELLDNATRYSPPHAKVHLSATEVQSGVAIEIEDGGVGLSEEARERAEHMLAEAQAGIDLNDLGETPRLGLAVVGRLAQTYDFRVSLRPSAYGGVRAVLVVPQVLLTTTPATGTAHGIGATSGPRPLRNPTPPPAGVEGSADARAGLKRSRDRVPPARQAGPQPSPPAHPEPVAGSLPQRRRRAPVAPPAAPAAGGQPSGRRTATASPAGTENGAAEVRGVEPGLWLGDFTRGLEGEPQGGDAGAAAEPQEPGGTARGEDEAAGSIRPERPARLRHGDGAPGPSNPSSGEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFH2</accession>
    <name>A0A0F7NFH2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_34160</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020672.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_34160"/>
    <dbReference type="EnsemblBacteria" id="AKH87225">
        <property type="protein sequence ID" value="AKH87225"/>
        <property type="gene ID" value="AA958_34160"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_34160"/>
    <dbReference type="OrthoDB" id="1899136at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="148"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="9"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH87225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="171" mass="18142" checksum="5919280583411231" modified="2015-07-22" version="1">MRAVLATRQKAAAAQVKQLEAELDRVRAALADAEEVHRHRAIGLEQYLEALADQDAPADVAGGVSRRKQVGPRRAVPHRRHATEVKELSPDYQALLAAAEGAGDDGLGARQAAVVLGWDSASASRVEGARARLKRLVERGWLVEPNPGRFTLLPPLSEQDAAGPGRPGGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFS2</accession>
    <name>A0A0F7NFS2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TerB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_30670</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020577.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_30670"/>
    <dbReference type="EnsemblBacteria" id="AKH87151">
        <property type="protein sequence ID" value="AKH87151"/>
        <property type="gene ID" value="AA958_30670"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_30670"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6482"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3680.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007791">
        <property type="entry name" value="DjlA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029024">
        <property type="entry name" value="TerB-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05099">
        <property type="entry name" value="TerB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158682">
        <property type="entry name" value="SSF158682"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TerB" evidence="2">
        <location>
            <begin position="61"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH87151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="180" mass="19286" checksum="2CC435D83033D668" modified="2015-07-22" version="1">MSMFDRIKDQAKGLQQSRGGARSGSQGSTGSGGGSRAQLVSMFKSQLSSMKTELKSGAYRDATMAVCALVAAADGHVHPAERERMESMIMTNDVLQNFPPEQLRQRFTKHLDRLTVDFHAGKAEALQEIAKAKKKAAEARAVIQTGFVIAGADGHIDPAEQQVLREACSALGLPPSEFGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NG00</accession>
    <name>A0A0F7NG00_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sugar ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_33610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019571.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_33610"/>
    <dbReference type="EnsemblBacteria" id="AKH86349">
        <property type="protein sequence ID" value="AKH86349"/>
        <property type="gene ID" value="AA958_33610"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_33610"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.7097"/>
    <dbReference type="OrthoDB" id="1303718at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002520061" evidence="2">
        <location>
            <begin position="21"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="431"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH86349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="455" mass="49240" checksum="E436ECF3B293057E" modified="2015-07-22" version="1">MLTPTRSKRTIRTLVPVATAAALLAACSGAGGGGSSGGDDSVNVVMVNNPQMVELQKLTAKHFTKKTGIEVNFTVLPENEVRDKISQDFANQAGQYDVATISNFEVPFFAENDWLLPLDEYAADDAKFDQEDVLAPMRESLTAEDGKLYAEPFYGESSFLMYRKDVFADNGLKMPDKPTWQQVADLAAEADGAEPGMKGICLRGLPGWGEVIAPLTTVVNTMGGTWFDENWEAQLTSPEFTKAAKFYVDLVREHGEAGAAQSGYAECLNNLTQGKTAMWYDATAATGSLEAEDSPVRGKIGYAPAPVDKTESSGWLYTWAWGVQKASERPESAWKFISWASSKEYEELVGKELGWANAPAGKRASTYSNPDYLKAAGSFADITREAIEGADPRDPGTQPRPAPGIQFVGIPEFSDLGTKVSQEISSAIAGKQSVEDALENSQELAEEVGGEYRDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NGB0</accession>
    <name>A0A0F7NGB0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Galactonate dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_33555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019560.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_33555"/>
    <dbReference type="EnsemblBacteria" id="AKH86338">
        <property type="protein sequence ID" value="AKH86338"/>
        <property type="gene ID" value="AA958_33555"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_33555"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.7086"/>
    <dbReference type="OrthoDB" id="1825548at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034593">
        <property type="entry name" value="Mandelate_racemase_DgoD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013341">
        <property type="entry name" value="Mandelate_racemase_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48080">
        <property type="entry name" value="PTHR48080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02746">
        <property type="entry name" value="MR_MLE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="SSF54826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MR_MLE" evidence="1">
        <location>
            <begin position="145"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="398" mass="43396" checksum="96EF83ED3FF58937" modified="2015-07-22" version="1">MLTVDTTRPTGPAGRISRVETLMLGTAWRDFGYVRVHTDEGLSGVGEITHPYRGREVCALAEAMSRRHLLGADPFDVEEIWLRLHQGDFLRGGDVGGIVLSGLDQALYDLMGKALGVPAYRLTGGACRDGVPVYANGWYDGERDPGVFAAKARATVAKGYGALKFDPFGSGLHELSPAELRRSVGLVAAVREAIGPDVELFIEGHARFAMPTAVRLLHELEPYGIGWLEEPLPWTHIERYAELRRRAAFPLAGGEHFHDRYEYKQLFATHAVDIVQPDLSMAGGLTEVRKIAAIADAHGMLVAPHNSNSPLCTTVSVHAALGIPNLKVLETFDGLLEPYVFEALRGTLPIAGGRIGLPTAPGLGVELADEVFAEHPPTHRFWNMFEDGWEKRDRSAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NGG9</accession>
    <name>A0A0F7NGG9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_33805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019605.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_33805"/>
    <dbReference type="EnsemblBacteria" id="AKH86383">
        <property type="protein sequence ID" value="AKH86383"/>
        <property type="gene ID" value="AA958_33805"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_33805"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.7139"/>
    <dbReference type="OrthoDB" id="2029859at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019004">
        <property type="entry name" value="YqeY/Aim41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042184">
        <property type="entry name" value="YqeY/Aim41_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09424">
        <property type="entry name" value="YqeY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="136" mass="14008" checksum="940939D908CE990A" modified="2015-07-22" version="1">MTAAAAGPPTDPGTTEDAQALRSLMRADLRAAMKARRRETVSALRTALAAIDNAEAVEAPAAPADEGSEHVAGARSGVGSAEAARRVLSAGDVRALLQAQITERRAEAGVYESAGRAEAADRLRREADALAAYLTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NGJ3</accession>
    <name>A0A0F7NGJ3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">L-2,4-diaminobutyric acid acetyltransferase</fullName>
            <shortName evidence="6">DABA acetyltransferase</shortName>
            <ecNumber evidence="4 6">2.3.1.178</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ectA</name>
        <name evidence="8" type="ORF">AA958_05300</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the acetylation of L-2,4-diaminobutyrate (DABA) to gamma-N-acetyl-alpha,gamma-diaminobutyric acid (ADABA) with acetyl coenzyme A.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>acetyl-CoA + L-2,4-diaminobutanoate = (2S)-4-acetamido-2-aminobutanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16901"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58761"/>
            <dbReference type="ChEBI" id="CHEBI:58929"/>
            <dbReference type="EC" id="2.3.1.178"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Amine and polyamine biosynthesis; ectoine biosynthesis; L-ectoine from L-aspartate 4-semialdehyde: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the acetyltransferase family. EctA subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.178" evidence="4 6"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_05300"/>
    <dbReference type="EnsemblBacteria" id="AKH86559">
        <property type="protein sequence ID" value="AKH86559"/>
        <property type="gene ID" value="AA958_05300"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_05300"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1112"/>
    <dbReference type="UniPathway" id="UPA00067">
        <property type="reaction ID" value="UER00122"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033816">
        <property type="term" value="F:diaminobutyrate acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019491">
        <property type="term" value="P:ectoine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012772">
        <property type="entry name" value="Ectoine_EctA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02406">
        <property type="entry name" value="ectoine_EctA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="7">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH86559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="158" mass="17356" checksum="B6871A9B5E699CA0" modified="2015-07-22" version="1">MDTPRIEDGAAIWRIARDSGSLDLNSSYSYLLWCRDFADTSVVARDSDGAPVGFVTGYIRPARPETLVVWQIAVDAAFRGRGLAGALLDGLTERALADRGIRRLETTITPDNSASDQLFRSYARRHGAGVDRDVLFHGEHFPDGHEPELLYRIGPLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NGK1</accession>
    <name>A0A0F7NGK1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">XRE family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_30655</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019080.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_30655"/>
    <dbReference type="EnsemblBacteria" id="AKH85852">
        <property type="protein sequence ID" value="AKH85852"/>
        <property type="gene ID" value="AA958_30655"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_30655"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6479"/>
    <dbReference type="OrthoDB" id="1746185at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="35"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH85852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="303" mass="33107" checksum="5F2A1B481E294299" modified="2015-07-22" version="1">MTVPTAAVHDPGIPLAGEHERGGRPVCRSVLGSRLRRLRQDRGIQLQAAAREIGASVAKLCRLELGQGGCKDHDVAALLDFYGVTDEDVLDEFAALTRGANAPSWWQEYSDLIPSQAETHLGLEEAATVIRSYQSQRIPDLLQTAAYARAITQLGFPRDPVQTVERRLHLLERRQQALTRADPPRCWVLLDEAALRRSVGAPGVMEGQLRHLLRLHLEHPTVTLDVVPLAAGGTAAVAQPMTMLRFAEPELPDVVCLDQLTGTVRIDKPGEVDRYRLALDNLAAATSTGTDAAVFLTRLLHGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NHA1</accession>
    <name>A0A0F7NHA1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SalK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_32115</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019325.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_32115"/>
    <dbReference type="EnsemblBacteria" id="AKH86097">
        <property type="protein sequence ID" value="AKH86097"/>
        <property type="gene ID" value="AA958_32115"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_32115"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6781"/>
    <dbReference type="OrthoDB" id="1438002at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH86097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="287" mass="30351" checksum="703ABB622482949E" modified="2015-07-22" version="1">MTSLPPRAGRRCQQVLNPLHSAIYFAPEFTEEFAGIGIDGWHAAYFTARSAAMGPVGPGVVAAVFYNYSHKLAARHLPAAWTAADPATVLATRLRVADAVLRRLLGEETIASPELAEAAELAQRAAAGGGRAGRPLYAAEADLPVPDAPHLALWHAATQLREHRGDSHDAVLAHAGLDGLESQVTHTASGFGFTPEFARYSRGWEPEEWAAAQDRLRARGLLAADGELTEAGTALRRELEDETDRVDLGPYAQLGAAGVARLTELATGYTTAALAAGAMPKDIFGKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NHA8</accession>
    <name>A0A0F7NHA8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_32165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019335.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_32165"/>
    <dbReference type="EnsemblBacteria" id="AKH86107">
        <property type="protein sequence ID" value="AKH86107"/>
        <property type="gene ID" value="AA958_32165"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_32165"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6792"/>
    <dbReference type="OrthoDB" id="1411221at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016780">
        <property type="term" value="F:phosphotransferase activity, for other substituted phosphate groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="259" mass="27786" checksum="C3DA37CEA613EA9C" modified="2015-07-22" version="1">MPKPSVAELRPVVHPPGVKDRRSGEHWAGRLYMREISLRVDRHLVNTRVTPNQLTYVMTLAGVLAAPALLVPGIAGALLGVLMVQLYLLLDCVDGEVARWKQQFSIGGVYLDRVGAYLCDAAVLVGFGLRAADPWGEGSVDWLWAFLGTLAALGAVLIKAETDLVGVARHQQGLPPVKESAAEPRSSGVAVARKAASALKFHRLILGIEASLLILLLAILDLIKGDLYFSRLGVAVLAAIAMLQTLLHLVSILASSRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NHM6</accession>
    <name>A0A0F7NHM6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_15880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020110.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_15880"/>
    <dbReference type="EnsemblBacteria" id="AKH86808">
        <property type="protein sequence ID" value="AKH86808"/>
        <property type="gene ID" value="AA958_15880"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_15880"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3346"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020246">
        <property type="entry name" value="Uncharacterised_SCO3924"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17260">
        <property type="entry name" value="DUF5326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="70" mass="7633" checksum="C48413B1EF4B5839" modified="2015-07-22" version="1">MKEITAGLPWWVTWVLIPAIVLVVFGSLIMALVGFIIGLLFKVLLAAALIAGAIFLVRKFMTASSSKNDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NIQ2</accession>
    <name>A0A0F7NIQ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tat pathway signal sequence domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_31015</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020590.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AKH87163">
        <property type="protein sequence ID" value="AKH87163"/>
        <property type="gene ID" value="AA958_31015"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_31015"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6554"/>
    <dbReference type="OrthoDB" id="199988at2"/>
    <dbReference type="Proteomes" id="UP000034283">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002520132" evidence="2">
        <location>
            <begin position="47"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="434"/>
            <end position="455"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH87163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="640" mass="69171" checksum="299C59D102FA4E33" modified="2015-07-22" version="1">MGRTTEEEEDRGGQRTRLDRRALLQSAVAVPAAGAVAALAADPAVAAGGAAPGAAGTGGRHGYDAESPRFALAVLPDTQYLFDADSADPEPLRATFRYLTAERGKANIAFMAHLGDVTEHGTADELRLAAATFRALDGSVPYSVLAGNYDVDGSQDDQRGDSPYLDDFGPDRYRRMPTFRGASDDGYNTCHVLRGGGREWLVLALDWRISDRGLRWAQGVLDRFPKLPAILTTHDLAWSGDDGAAQLSDHGRRLWDGLIRGNDQIFLALGGHYWPPGRTVLTNDAGNDVHVHLTNYQDRYYGGAGMIRLYGFDLARGVIDVETFSPWFLARDPGRRSPLAAETVELTGPADRFSMEIGFTGRFAGFAPPVRPRPRPPATVLPRGTVAYWRFDADGLAAAGRDGEPVADGARARDLSGNGNDLTVRRLHDSGPAALTWSDGHHEGQPAHASLRFDGGKGPDRGAVLTTAAGAPLNSEKFTSGYTIETFVKLPEPFEGDHAWMGILSWEGRNGDAGKTTGWSPDEPTCSLNLSPERFLQYVVYPHRQDADPTSWSHTLPVGRWMHLAVVNDGRRTVVYVDGSKIARNPAQRSTGIATLGKPFVVGATQFDEKFGQGFYGWIGDTRIVARALAPRDFLAPAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NIX1</accession>
    <name>A0A0F7NIX1_9ACTN</name>
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        <submittedName>
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        </submittedName>
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    </gene>
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        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
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            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
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        <property type="protein sequence ID" value="AKH86454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="AKH87223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_00110"/>
    <dbReference type="EnsemblBacteria" id="AKH86454">
        <property type="protein sequence ID" value="AKH86454"/>
        <property type="gene ID" value="AA958_00110"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH87223">
        <property type="protein sequence ID" value="AKH87223"/>
        <property type="gene ID" value="AA958_34145"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_00110"/>
    <dbReference type="KEGG" id="strc:AA958_34145"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.25"/>
    <dbReference type="Proteomes" id="UP000034283">
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    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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        <location>
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            <end position="78"/>
        </location>
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        <location>
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            <end position="111"/>
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        <location>
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            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="165"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
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            <end position="246"/>
        </location>
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    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="55"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH86454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH87223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="260" mass="28129" checksum="E100EC3D335D8770" modified="2015-07-22" version="1">MIGAGVLFAFPFYVFLSISLKTPDQVAADPLGPPSGLHLDNYTTAWREAALGQALFNSTVVAVISVALLVALGSPAAYTLARRASRVSYATYLLFLLGIMIPLQLGMVPLYQLMRDANLLQTYTSLIIFNIGSQLPITVFLYAGFTRALPREYEEAARVDGAGTLRTFLAVVFPLLRPVTGTVVIISAINVWNEFLTPLLYVGGSAQQTLPVAIFAFRGEFSTNWGVIFAGMVLAILPILLVYFLLQKTIIKGFASGLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NIY3</accession>
    <name>A0A0F7NIY3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribonuclease BN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_14725</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
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            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP011492">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AKH86772">
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        <property type="gene ID" value="AA958_14725"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_14725"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3101"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Virul_fac_BrkB"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="yihY_not_rbn"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="143"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="220"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="252"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH86772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="307" mass="33136" checksum="ADC222950A4E6DC0" modified="2015-07-22" version="1">MRSGVRRAPRGRRGCRDCMTALRRTSVSLWNQDADEWAAALTYYAILALVPGVLVTVSLIGIAGPAATRDLISQVTAMVPADVRAVTERTLRDMADQRAGAWLLAITGTAGALWSASGYLAVFRRSLHTMHGVRDHRPFWRTAPQTVLTAAALLALLVASTILLMLTGEAARTLGSALGMDYAALTAWNALKWPLLLCVAVVLVLLLFRSGPPPTRRMRRIAPGGALALVLWLAASTGFALYITWAGTYNRLYGSLAGSIVFLVWLWVSNLTLLAGAQFNAELARLHPQRAREQIAAPTATDPDPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NJ22</accession>
    <name>A0A0F7NJ22_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Lanthionine synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_15645</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_15645"/>
    <dbReference type="EnsemblBacteria" id="AKH86802">
        <property type="protein sequence ID" value="AKH86802"/>
        <property type="gene ID" value="AA958_15645"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_15645"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3296"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd04793">
        <property type="entry name" value="LanC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033889">
        <property type="entry name" value="LanC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007822">
        <property type="entry name" value="LANC-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05147">
        <property type="entry name" value="LANC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01950">
        <property type="entry name" value="LANCSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM01260">
        <property type="entry name" value="LANC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH86802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="406" mass="42856" checksum="647AAE49EA389F28" modified="2015-07-22" version="1">MAAELADTLAMPPDVDYGDDVRPDSPRWRDQSLSKGAAGIAVLHGLRVQHGLGGTEAMQAWLARATRDGLTAGPGAGLWFGAPAVGFALHLAAPGRYQGALARLDAAVAQLVRTRLTAAAQRMDAARRPSQYEFDLTRGLVGLGAYLLRRDPGGALLRRVLDYLVSLTRPIPADDAAGSRAPGWWTADLPAGMRDSSFDHGHANLGMAHGITAAQALLALAMREGITVDGHADAIETISLHLDVWRQPSAAGPWWPERITLDELEDGRPHRDGPARPSWCYGTPGIARAQQLAALALDDTARQHTAEDALTRCLADPAQLARVTDPALCHGWAGIVATAWHAAADATTPGTVHGLDRLLVRLLDHAHDTAPDQAIGLIEGSAGIALTLHSIATDTAGGWPTCLLIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MXB0</accession>
    <name>A0A0F7MXB0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Crystallin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_00300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH80865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014231.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH80865">
        <property type="protein sequence ID" value="AKH80865"/>
        <property type="gene ID" value="AA958_00300"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_00300"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.72"/>
    <dbReference type="OrthoDB" id="1661477at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4080.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005502">
        <property type="entry name" value="Ribosyl_crysJ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036705">
        <property type="entry name" value="Ribosyl_crysJ1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03747">
        <property type="entry name" value="ADP_ribosyl_GH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101478">
        <property type="entry name" value="SSF101478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH80865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="335" mass="35357" checksum="6FCEF04CD704F15C" modified="2015-07-22" version="1">MTRATGALLGLAIGDAMGFPTEFNTFAQIEAEFGEWRSLPLPVSSGTAYVTDDTQMTLALGEALHTVLAGGPLTAGRMEPPVRAHFLSWYHSPENNRAPGGTCLRACEALERGGPWQRASVVGSKGCGANMRVAPIGLVPGLSAEQRSGAAQLQSGLTHGHPTALAAGDVTAHTVHLLVQGTDPQDLLPLLRAYAEANRTVYRADWLGNLAEHAQDVDRVSFISRGWQECLAVLDRVEAALPDADPDADPCLATGEGWIAEEAFATALFCFLQHPDDPPAAVRRGAYSGGDSDSIAALAGAFAGACHGAAAWPPEWVEVIEYRERLLALGAAWDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MXP2</accession>
    <name>A0A0F7MXP2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8 10">Uracil-DNA glycosylase</fullName>
            <shortName evidence="8">UDG</shortName>
            <ecNumber evidence="4 8 10">3.2.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ung</name>
        <name evidence="12" type="ORF">AA958_01235</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 8 10">Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 10">
            <text>Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.</text>
            <dbReference type="EC" id="3.2.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8 10">Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.27" evidence="4 8 10"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014380.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_01235"/>
    <dbReference type="EnsemblBacteria" id="AKH81015">
        <property type="protein sequence ID" value="AKH81015"/>
        <property type="gene ID" value="AA958_01235"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_01235"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.270"/>
    <dbReference type="OrthoDB" id="1260295at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004844">
        <property type="term" value="F:uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd10027">
        <property type="entry name" value="UDG-F1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00148">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002043">
        <property type="entry name" value="UDG_fam1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018085">
        <property type="entry name" value="Ura-DNA_Glyclase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11264">
        <property type="entry name" value="PTHR11264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="SSF52141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00628">
        <property type="entry name" value="ung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00130">
        <property type="entry name" value="U_DNA_GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 8 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 8 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDG" evidence="11">
        <location>
            <begin position="47"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8 9">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AKH81015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="226" mass="24915" checksum="A454CBE12027127E" modified="2015-07-22" version="1">MLPPSWQDALGKELEKPYFTRLESFVEEERARGPVYPPREEVFAALDATPYENVKVLVLGQDPYHGAGQGHGLCFSVRPGVRTPPSLRNIFKELRDDLGHPVPDNGYLMPWAEQGVLLLNAVLTVRESEANSHKGQGWEEFTDAVIRAVAERPDPAVFVLWGAYARKKLPLIDTARHVVVQGAHPSPLSAKKFFGSRPFSQIDAAVAAHGHAPIDWRIPDLAAAGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MXS7</accession>
    <name>A0A0F7MXS7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_01460</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014415.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_01460"/>
    <dbReference type="EnsemblBacteria" id="AKH81050">
        <property type="protein sequence ID" value="AKH81050"/>
        <property type="gene ID" value="AA958_01460"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_01460"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.321"/>
    <dbReference type="OrthoDB" id="990666at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519036" evidence="2">
        <location>
            <begin position="22"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="HTH lysR-type" evidence="3">
        <location>
            <begin position="2"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH81050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="299" mass="32357" checksum="AA9A95CEF6A27B72" modified="2015-07-22" version="1">MLNLERLRTLAAVARHGSVSAAAGGLHITTSAVSQQLAKLERETGQQLLAKNGRGIRLTDAGRLLAEHATRILSQVEAAQSELEAHRGRPVGELGLAAFPTAARGLFPAALAALRRDHPELRVRLREQEPDETVPGVMRGDHDLGVVLDWYNKPLPLPPGLSRAPLLDDLADVAVPEGHPLADRADVVLEDFAADDWISWPESEFCHDWLVFTLRAKGIEPHIAHTAEEHHTQLALIAAGLGVAVAPRLGRGAVPAGVRILPVRGAMQRHIYAIWRSDADRRPSIREAVRALQAAGRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0C9</accession>
    <name>A0A0F7N0C9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_00230</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH80853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014220.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH80853">
        <property type="protein sequence ID" value="AKH80853"/>
        <property type="gene ID" value="AA958_00230"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_00230"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.53"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002518992" evidence="2">
        <location>
            <begin position="23"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH80853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="168" mass="18042" checksum="749AED4FD07E2517" modified="2015-07-22" version="1">MLLLAVIACSGSLDPTPKPARQAGNGNQAEEPEAAEFPDKDLIVTATCARVTVTGWDVRTWKTAALRTFDIPAEVAVDREDSDARSPLIELCGNAFRGLGGPDDGPREAPEDSRRRLFDKDDTRMAVLLLNPETGGTLAGYLDAEGKVTALSRQDSDVFSASFISMRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0D9</accession>
    <name>A0A0F7N0D9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ThuA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_07465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015445.1">
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_07465"/>
    <dbReference type="EnsemblBacteria" id="AKH82095">
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        <property type="gene ID" value="AA958_07465"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_07465"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1564"/>
    <dbReference type="OrthoDB" id="1452706at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029010">
        <property type="entry name" value="ThuA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06283">
        <property type="entry name" value="ThuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ThuA" evidence="1">
        <location>
            <begin position="8"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="219" mass="24334" checksum="CB4D7304CFBBDCDE" modified="2015-07-22" version="1">MTSGHRQALVVRGGWDGNFPVQTTNLFMPFLRGNGFRILVEDSLEVYEDEDLLAETDLIVQCWTRGDITAGESAGLIAAVRAGTGFAGWHGGVVDAFREDLDYQLLTGGKFLTCPQGPRRHRIHLTAEYADHPVIAGLGDFDVDTEPYWALNDPLNDVLATLTFDADDTRRRSVNIPAVWVRTWGKGRVFVSTVGHGPDDFRNPHVRTLTERGLLWASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0S1</accession>
    <name>A0A0F7N0S1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Calcium-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_08255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_08255"/>
    <dbReference type="EnsemblBacteria" id="AKH82225">
        <property type="protein sequence ID" value="AKH82225"/>
        <property type="gene ID" value="AA958_08255"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_08255"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1741"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013658">
        <property type="entry name" value="SGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005511">
        <property type="entry name" value="SMP-30"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08450">
        <property type="entry name" value="SGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01790">
        <property type="entry name" value="SMP30FAMILY"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGL" evidence="1">
        <location>
            <begin position="14"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="280" mass="29441" checksum="5C006030CFAA5A67" modified="2015-07-22" version="1">MTMLDVAVRTRAELGEGPTWDPAAGRLIWVDILGARIHAYDPATGRRTVQTTEQHVGSAKPRAGGAGYVVNLRDGVGLYDADGAFRWLVHEPVAGRRGNEAMVAPDGALWAGTMRYDSTPGGGTLARVTGDGTQTVVLDDVTVSNGTGWSPDGRLMYYADTPTGRIDVFDTDGAGVTGRRLFAAVEDTPGSPDGLCVDAEGYVWVALWDGAAVRRYAPDGTLDRTVEVPVRRPTSCAFGGPELTDLYITSSSLADAHPLAGSVLVLPDAGRGLPQAPFEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0V1</accession>
    <name>A0A0F7N0V1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Thiamine permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AA958_01055</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH80989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014355.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_01055"/>
    <dbReference type="EnsemblBacteria" id="AKH80989">
        <property type="protein sequence ID" value="AKH80989"/>
        <property type="gene ID" value="AA958_01055"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_01055"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.232"/>
    <dbReference type="OrthoDB" id="326558at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026030">
        <property type="entry name" value="Pur-cyt_permease_Fcy2/21/22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806">
        <property type="entry name" value="PTHR31806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002744">
        <property type="entry name" value="Pur-cyt_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="40"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="111"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="255"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="289"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="336"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="364"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="407"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="443"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH80989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="478" mass="50148" checksum="CE0F3A7585D6D7C4" modified="2015-07-22" version="1">MTAQSPPHATVQAEPPPAFDVHGVEPIPEHGRDSSARDQWWIWVGANVAPINWVLGALGISLGLSLLETLVVIAAGNALGCAVFGAFNLMGHRTGVNQMVLGRAAFGQRGAIIPGVVQGVLTMGWVGVNTWVILDLAITLLAKLGVHGGDGLKYLVAGVIMALQLGLAVFGFYAIRTFEKWTVPATVAVMAVMTVLSLTQVDVHWGGGSAEGGGETFTAVTQLLTAIGVGWGVSWVPYSADYSRFVAPGVPGRRVFWATALGMYVPTVWLAALGACLASAGKGGDPSHLVVAAFGAMALPVLLLIMHGPVATNILNLYSCALAALSIGVRLARWKVTLLAGVVATGVLLVFMQSDSFAQSFDHWMVSILVWISPWAGVMMTEFFVLREGRIDVASLYTADGPRWRGRALVALGTGIAAGWCWQYGLVSAMQGPLARALGNTDFSWLAGGLVAGGLHFLLARREERAAGRASAVAGTTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N103</accession>
    <name>A0A0F7N103_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_08680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015643.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH82295">
        <property type="protein sequence ID" value="AKH82295"/>
        <property type="gene ID" value="AA958_08680"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_08680"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1831"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH82295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="64" mass="6725" checksum="950F8D888AB43001" modified="2015-07-22" version="1">MRLYGVDLAALRTAAGGDWLAFLAAAERRLTELVDDVAPAGPARVAALYGRLTGPRSTLFQPPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N1A7</accession>
    <name>A0A0F7N1A7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_02155</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014533.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_02155"/>
    <dbReference type="EnsemblBacteria" id="AKH81169">
        <property type="protein sequence ID" value="AKH81169"/>
        <property type="gene ID" value="AA958_02155"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_02155"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.464"/>
    <dbReference type="OrthoDB" id="652377at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
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        <property type="entry name" value="PEP-util_enz_mobile_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036637">
        <property type="entry name" value="Phosphohistidine_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002192">
        <property type="entry name" value="PPDK_AMP/ATP-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00391">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="SSF52009"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPDK_N" evidence="3">
        <location>
            <begin position="109"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="PPDK_N" evidence="3">
        <location>
            <begin position="251"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers" evidence="2">
        <location>
            <begin position="651"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="613"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="725"/>
            <end position="746"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH81169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="746" mass="75905" checksum="4BCC4EAC0FE8F7AE" modified="2015-07-22" version="1">MEPLMATEAERTADADPAARAADADQAARAARTERAAGGAWPAVLPLHARPARDPGSAGAKAANLARAAAAGLPVLPGFVLTDPALAPGAPAGPGALYAAWRDLSEGGRRPLIVRSSSAYEDAADSSMAGWYETVPDVRGWDDFAAAVRRVLDSAARGLVGPAAAPREAPLRAGAPGRMAVLVQPMLRAAAGGVMFGADPVAGRHDRLLVSAVDGGPGTLVDGTAQGVRYQLTRCGRRIAAVPAEPPGARLLGRGRLARLASLARRAERVFGEPQDVEFGFDADGRLWLFQSRPITAMPPRPPRTARLLGPGPVAETFPAVLQPLEEDLWVAPMSHGLTVALDIAGTAPRRHLRALPAVTTVDGRAAADLRLLGAVKSAHPVRDFMNPLRGARLLGAAWRTGRLRTALPVLARDLMAEVDEQLAGLPEPAAMAGGRLLDAAGWGRTVLSALHAQESLAGALPGAGTGATAAGEALAVLAEVPRQDAAHDDAELIARHPVLLALLPPALGAAPPLPVRTRWSGVPRGVGALPVREGLRLRIRWVQEMQSRVVAELAERLAAAGALDGAARVALLRWPELVALADGRGLPRDFAERLPRPERLGLPAAFRLAGGRPVAEPQDPAGAGPAAGGGQGAGGGSGAGVAWDGAGERPERAVLVVPVLDPGLAPQLAGLAGLVAETGSALSHLAVLAREFGVPTAVGVPGAVERFPPGTALAVDGTTGAVTAAGGEARTGGDAAHGDSPGAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N1G2</accession>
    <name>A0A0F7N1G2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome C biogenesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_09320</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015741.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_09320"/>
    <dbReference type="EnsemblBacteria" id="AKH82395">
        <property type="protein sequence ID" value="AKH82395"/>
        <property type="gene ID" value="AA958_09320"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_09320"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1967"/>
    <dbReference type="OrthoDB" id="1617952at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003834">
        <property type="entry name" value="Cyt_c_assmbl_TM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02683">
        <property type="entry name" value="DsbD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="DsbD" evidence="2">
        <location>
            <begin position="10"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH82395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="297" mass="30216" checksum="63D20CDBFE38DB16" modified="2015-07-22" version="1">MADLPLALALGAGMLAAVNPCGFALLPAYLSLLVLGDDAPGRTVAVGRALAATAAMTAGFAALFGIFGLAVQPVAGQVQQHLPWFTIAFGLLVAAAGAWLLAGRQLSVLAPKLRRAPKLTRSLPSMVLFGMAYATASLGCTIAPFLAIVVSAFRSGSTAEGIALFAAYAAGMGLIVGAASLSVALTRTTAVTPLRRLGAATPRLGGGVLLLVGAYVAYYGWYEIRAQRDPATTDPVIEEAGAVQRALSDAVDAAGPAVIAVFCAALLMAALIIRTRRRTRRLARTGTEAGPAASRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N1H2</accession>
    <name>A0A0F7N1H2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Streptogrisin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AA958_02915</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014661.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH81298">
        <property type="protein sequence ID" value="AKH81298"/>
        <property type="gene ID" value="AA958_02915"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_02915"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.623"/>
    <dbReference type="OrthoDB" id="1110723at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004236">
        <property type="entry name" value="Pept_S1_alpha_lytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001316">
        <property type="entry name" value="Pept_S1A_streptogrisin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02983">
        <property type="entry name" value="Pro_Al_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001134">
        <property type="entry name" value="Streptogrisin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00861">
        <property type="entry name" value="ALYTICPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519029" evidence="7">
        <location>
            <begin position="34"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="Pro_Al_protease" evidence="9">
        <location>
            <begin position="100"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="8">
        <location>
            <begin position="195"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="233"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="314"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="308"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001134-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001134-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AKH81298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="358" mass="36068" checksum="DE51AA31DB2B6EF6" modified="2015-07-22" version="1">MRYRAISKSRYALAGVGAAALIAGSLTLATANASTSEPVADTLSSAAAGELAGTLVQDLKGGAAGAYYDAQAKELVVNVVNDEAAEQAEAAGARARTVDHTTKELKAAKADLTQGAIAGTSRALDPVTNQVVVTADSTVKGAELAQLKKEVAAQDGKAVLKRTAGTFKPYISGGDAIYTGGSRCSLGFNVTKDGEPYFLTAGHCVELGGSSWSESSGGPVIGEAEAATFPGNDRALVKYTADVEHPSEVDTYDGSAQEITGAREATVGETVQRSGSTTQLHDGSVVALDVSVTYPEGTVDGLIQTDVCAEPGDSGGALFAGSDAIGLTSGGSGDCTNGGETFFEPVVAALDEYGATIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N1I5</accession>
    <name>A0A0F7N1I5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Haloacid dehalogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_02550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAD-like hydrolase superfamily. S-2-haloalkanoic acid dehalogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014602.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_02550"/>
    <dbReference type="EnsemblBacteria" id="AKH81239">
        <property type="protein sequence ID" value="AKH81239"/>
        <property type="gene ID" value="AA958_02550"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_02550"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.546"/>
    <dbReference type="OrthoDB" id="1204073at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019120">
        <property type="term" value="F:hydrolase activity, acting on acid halide bonds, in C-halide compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02588">
        <property type="entry name" value="HAD_L2-DEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006328">
        <property type="entry name" value="2-HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01493">
        <property type="entry name" value="HAD-SF-IA-v2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01428">
        <property type="entry name" value="HAD_type_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="242" mass="25865" checksum="E985B76C518B6E83" modified="2015-07-22" version="1">MTGAEFDPGSVRALAFDIFGTTVDWRTGVAEQVARLAARRGVELDGAGFADEWREMYLPSMGRVNSGERGWAYLDVLHRESLDELLERHGVGAAFGDADRAELVRAWHRLPAWDDAAAGLTRLRGRYVVAALSNGGFALLTHLVKAAGLPFDCILSAELAQHYKPDPSPYLTAARLLDVAPGELLMVACHGWDLAGARDAGLRTAFVSRPLEKGPGGGADADVPADVAARDFTLLADLLGCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N1K5</accession>
    <name>A0A0F7N1K5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">DNA-directed RNA polymerase subunit omega</fullName>
            <shortName evidence="11">RNAP omega subunit</shortName>
            <ecNumber evidence="2 11">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">RNA polymerase omega subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10 11">Transcriptase subunit omega</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">rpoZ</name>
        <name evidence="12" type="ORF">AA958_03085</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 11">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9 11">The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the RNA polymerase subunit omega family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="2 11"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018836705.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_03085"/>
    <dbReference type="EnsemblBacteria" id="AKH81328">
        <property type="protein sequence ID" value="AKH81328"/>
        <property type="gene ID" value="AA958_03085"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_03085"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.658"/>
    <dbReference type="OrthoDB" id="1864134at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.940.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00366">
        <property type="entry name" value="RNApol_bact_RpoZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003716">
        <property type="entry name" value="DNA-dir_RNA_pol_omega"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006110">
        <property type="entry name" value="Pol_omega/Rpo6/RPB6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036161">
        <property type="entry name" value="RPB6/omega-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34476">
        <property type="entry name" value="PTHR34476"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01192">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01409">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63562">
        <property type="entry name" value="SSF63562"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00690">
        <property type="entry name" value="rpoZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11 12" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6 11" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AKH81328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="90" mass="9721" checksum="CF6AC39249120A08" modified="2015-07-22" version="1">MSSPITAPEGIINPPIDELLEATDSKYSLVIYAAKRARQINAYYSQLGEGLLEYVGPLVDTHVHEKPLSIALREINAGLLTSEATEGPAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N1L9</accession>
    <name>A0A0F7N1L9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amino acid ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_06355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015244.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_06355"/>
    <dbReference type="EnsemblBacteria" id="AKH81891">
        <property type="protein sequence ID" value="AKH81891"/>
        <property type="gene ID" value="AA958_06355"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_06355"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1327"/>
    <dbReference type="OrthoDB" id="776281at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028081">
        <property type="entry name" value="Leu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13458">
        <property type="entry name" value="Peripla_BP_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peripla_BP_6" evidence="1">
        <location>
            <begin position="17"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="367" mass="38215" checksum="B9AFB337974995B8" modified="2015-07-22" version="1">MAAMVTQAPPPRRDDEPVRIGALAPLTPPGWAEAGRHLVAGLELGAREVNDAGGIAGRPLELLVRDTAADPRRAAAAVDELAGLGVAALAGEYHSVVARTAAARADALGVPFLCSSAVLDALTEQPADGIARIAPAQTHGWRLYADFLLGAGHRRLAVAAQPSVYWASGTRILHDRLAPHGGTVTELDVGALTPEALCDALAASGATALLLLVGHPEPAVPLVRSVRRDPRLAGMLLGAPAGQPEFDEWAALLGAEGAGVPFLRYLPERLTPLGVRVEAALRERLAGAPSFVAFEGYDTLAVLAAVLRGGAGARTAAWGDVAVDGTRGPIRFSRVPGIDVWQWAWPPVQVVDRDPAEPGRFRVLHTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N1Z4</accession>
    <name>A0A0F7N1Z4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">dITP/XTP pyrophosphatase</fullName>
            <ecNumber evidence="6">3.6.1.66</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Non-canonical purine NTP pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Non-standard purine NTP pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Nucleoside-triphosphate diphosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Nucleoside-triphosphate pyrophosphatase</fullName>
            <shortName evidence="6">NTPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_10700</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>H2O + ITP = diphosphate + H(+) + IMP</text>
            <dbReference type="Rhea" id="RHEA:29399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>H2O + XTP = diphosphate + H(+) + XMP</text>
            <dbReference type="Rhea" id="RHEA:28610"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:61314"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>dITP + H2O = dIMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28342"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61194"/>
            <dbReference type="ChEBI" id="CHEBI:61382"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the HAM1 NTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.66" evidence="6"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015956.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_10700"/>
    <dbReference type="EnsemblBacteria" id="AKH82615">
        <property type="protein sequence ID" value="AKH82615"/>
        <property type="gene ID" value="AA958_10700"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_10700"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2251"/>
    <dbReference type="OrthoDB" id="1824064at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035870">
        <property type="term" value="F:dITP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036220">
        <property type="term" value="F:ITP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017111">
        <property type="term" value="F:nucleoside-triphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036222">
        <property type="term" value="F:XTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009146">
        <property type="term" value="P:purine nucleoside triphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00515">
        <property type="entry name" value="HAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01405">
        <property type="entry name" value="Non_canon_purine_NTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020922">
        <property type="entry name" value="dITP/XTP_pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002637">
        <property type="entry name" value="Ham1p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
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        <property type="entry name" value="PTHR11067"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ham1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF52972"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00042">
        <property type="entry name" value="TIGR00042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="10"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="157"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="185"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH82615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="203" mass="20815" checksum="768589B604A3A386" modified="2015-07-22" version="1">MTAHRLVLATRNAGKITELRAILGEAGVDAELLGAADFPDVPDVPETGVTFAGNALLKAHALARATGLPAVADDSGLCVDVLGGAPGIFSARWAGRHGDDAANLALLLAQLSDVGPGHRAAHFACAAALALPDGTERVAEGKLEGTLRYEPAGTGGFGYDPVLQPLGEDRTCAELTPEEKNAISHRGKAFRALAPAVRELLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N215</accession>
    <name>A0A0F7N215_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_07135</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015381.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_07135"/>
    <dbReference type="EnsemblBacteria" id="AKH82031">
        <property type="protein sequence ID" value="AKH82031"/>
        <property type="gene ID" value="AA958_07135"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_07135"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1495"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
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        <property type="entry name" value="Put_sensor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13796">
        <property type="entry name" value="Sensor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="Sensor" evidence="3">
        <location>
            <begin position="15"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="2">
        <location>
            <begin position="229"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH82031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="430" mass="46121" checksum="B2E93943C3144B3B" modified="2015-07-22" version="1">MIFRNWALAGVRALALTVLCTAVSITLFVLTLVSVVLIPVLGIGLVTTPWVLEGVRMQANLRRLLAAQWSDVRIPATYRPWPPDLHGGLIGQAQRTRHLLTDPSTWRDLRWLFTDMIAGTVLAVVTVALTFYPLEGYVIAAGVWDPLTSGGDTTYWYGFVPVSSQATALMAAGLGTALLAVGLFTSHRLIGLHFQMTKGVLAPREVELAERVARLTETRSDAVDNSAAELRRIERDLHDGAQARLVAMGMSLGTIEALIEKDPARAKELVSRARGESAEALTELRDLVRGIHPPVLAERGLADAVRALALRMPVPVEVDIDLGTPPGRAAEPVESAAYFAVSEVLTNAVKHAKAQRVWLDMGHRDGMLRIAITDDGRGGASLDKGSGLAGVERRLGTFDGVLAVNSPVGGPTMVTLEIPCALSSPKTSSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N271</accession>
    <name>A0A0F7N271_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Biotin synthase</fullName>
            <ecNumber evidence="3 13">2.8.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">bioB</name>
        <name evidence="17" type="ORF">AA958_00930</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>(4R,5S)-dethiobiotin + [sulfur carrier]-SH + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2 5'-deoxyadenosine + [sulfur carrier]-H + biotin + 2 L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:22060"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="ChEBI" id="CHEBI:149473"/>
            <dbReference type="EC" id="2.8.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13 14">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="13 14">Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13 14">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="13 14">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 13">Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the radical SAM superfamily. Biotin synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.6" evidence="3 13"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH80967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014333.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_00930"/>
    <dbReference type="EnsemblBacteria" id="AKH80967">
        <property type="protein sequence ID" value="AKH80967"/>
        <property type="gene ID" value="AA958_00930"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_00930"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.206"/>
    <dbReference type="OrthoDB" id="940969at2"/>
    <dbReference type="UniPathway" id="UPA00078">
        <property type="reaction ID" value="UER00162"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004076">
        <property type="term" value="F:biotin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01694">
        <property type="entry name" value="BioB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010722">
        <property type="entry name" value="BATS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002684">
        <property type="entry name" value="Biotin_synth/BioAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024177">
        <property type="entry name" value="Biotin_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22976">
        <property type="entry name" value="PTHR22976"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06968">
        <property type="entry name" value="BATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001619">
        <property type="entry name" value="Biotin_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00876">
        <property type="entry name" value="BATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00433">
        <property type="entry name" value="bioB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13 14" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="4 13 14" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9 13" id="KW-0093">Biotin biosynthesis</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="11 13 14" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13 14" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Radical SAM core" evidence="16">
        <location>
            <begin position="47"/>
            <end position="277"/>
        </location>
    </feature>
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        <location>
            <begin position="325"/>
            <end position="383"/>
        </location>
    </feature>
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        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
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        <location>
            <position position="69"/>
        </location>
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            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
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        </ligand>
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        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
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            <note>4Fe-4S-S-AdoMet</note>
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    </feature>
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        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
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        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13 14">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13 14">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010765"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012236"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001619-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AKH80967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="383" mass="40301" checksum="77FE804C3B7ED91F" modified="2015-07-22" version="1">MDLLSTLVDKGLRREAPTRDEALAVLRTPDESVLDVVAAAGKVRRAFFGRRVKLNYLVNLKSGLCPEDCSYCSQRLGSEAGILKYTWLKADQAAEAAAAGVAGGAKRVCLVASGRGPTDRDVDRVSETIAAIKEQNGDVEVCACLGLLSDGQAERLKAAGADAYNHNLNTSEATYADICTTHGYEDRVRTVQQAQAAGMSACSGLIAGMGESDEDLVDVVFALRALDPDSVPVNFLIPFEGTPLAGEWDLTPQRCLKILAMVRFVCPDVEVRLAAGREIHLRTLQPLALHLANSVFLGDYLTSEGQAGKADLEMIADAGFEVEDAGTTTLPPHRAADGPAPEAGPAGGPAGGPAAADEPPREARTDLVAVRRRGAGTELPPNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2W0</accession>
    <name>A0A0F7N2W0_9ACTN</name>
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        <recommendedName>
            <fullName evidence="4">Mg-protoporphyrin IX chelatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_05345</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
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            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
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    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Mg-chelatase subunits D/I family.</text>
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    <dbReference type="EnsemblBacteria" id="AKH81718">
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    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_05345"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1121"/>
    <dbReference type="OrthoDB" id="1068772at2"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA+_ATPase"/>
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    <dbReference type="InterPro" id="IPR041702">
        <property type="entry name" value="BchD/ChlD_VWA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045006">
        <property type="entry name" value="CHLI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041628">
        <property type="entry name" value="ChlI/MoxR_AAA_lid"/>
    </dbReference>
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        <property type="entry name" value="Cob_chelat_sub_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000523">
        <property type="entry name" value="Mg_chelatse_chII-like_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32039">
        <property type="entry name" value="PTHR32039"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA_lid_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="VWA_2"/>
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    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cob-chelat-sub"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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            <end position="655"/>
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    </feature>
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            <begin position="411"/>
            <end position="431"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00030759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH81718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="722" mass="75156" checksum="122F9EC43E5BD3E2" modified="2015-07-22" version="1">MNTGAPHYPFTAVVGMAELRLALLLNAVSPAVGGVLVRGEKGTAKSTAVRALAALLPEVAVVPGCRFSCDPAAPDAGCPDGPHEAARPRGVRAARMVELPVGASEDRLAGALDIERALAEGRKTFEPGLLAEAHRGVLYVDEVNLLHDHLVDLLLDAAAMGANYVEREGVSVRHAARFLLVGTMNPEEGELRPQLLDRFGLTVEVAASREPAERADVVRRRLAYDADAAGFAARWAAEEDALRARIAAARALLPGVVLGDAALRQITATCAAFEVDGMRADIVMARTATALAAWSGRTEVAAEDVRQAALLALPHRRRRNPFDAPGLDEEKLDDTLREHGGTGEDPPDGDGGGAPPGAADGPDGPHGPDAARQGQPGAAEDPAPQAPSAADAAPEPPGSAPAATRGPAEEPGAEPRPPGTAPPPPGEQPAAPAEPFRTRRLDVPGVGEGAAGRRSRARTAHGRTTGARRPRGALGTLHLAATVQAAAPHQHARGRRGPGLVVRRDDLREAVREGRESNLVLFAVDASGSMGARQRMGAVKGAVLSLLLDAYQRRDKVGLVTFRGREAEVALPPTSSVDAAAVRLERLPTGGRTPLAAGLLRARETLRVERLRDPARRPLLVVVTDGRATGGDEPVGRAARAARLLAAEGVASVVVDCESGPVRLGLAGELARELRGTAVALGELRAETVSGLVREAREDRRARAVREEPGTGRGPASSRRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N336</accession>
    <name>A0A0F7N336_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_09420</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015756.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_09420"/>
    <dbReference type="EnsemblBacteria" id="AKH82411">
        <property type="protein sequence ID" value="AKH82411"/>
        <property type="gene ID" value="AA958_09420"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_09420"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1988"/>
    <dbReference type="OrthoDB" id="1948240at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019554">
        <property type="entry name" value="Soluble_ligand-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10531">
        <property type="entry name" value="SLBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519732" evidence="2">
        <location>
            <begin position="29"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="HhH1" evidence="3">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="HhH1" evidence="3">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH82411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="221" mass="22313" checksum="F95E032A6254D8BA" modified="2015-07-22" version="1">MWIRLRCGLEPGTCAALVLVLVAGVALAAYHFWSGRPQPVHPPEARGSAPSPAAEAAVPDTAGEPGASAAADVVVDVVGKVREPGVHRLPAGSRVEDALRAAGGVRPGAEADGLNRARPLVDGEQIVVGEPPPAASVAPPAPTPSPPAGGGSPAAGPSAVVSLNSATLEQLDALPGIGPVLAQHIIDFRDQNGGFTDIEQLRDVNGIGDSRFADLRPHVQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N383</accession>
    <name>A0A0F7N383_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Folate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_13690</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016440.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_13690"/>
    <dbReference type="EnsemblBacteria" id="AKH83110">
        <property type="protein sequence ID" value="AKH83110"/>
        <property type="gene ID" value="AA958_13690"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_13690"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2881"/>
    <dbReference type="OrthoDB" id="1984573at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013977">
        <property type="entry name" value="GCV_T_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006222">
        <property type="entry name" value="GCV_T_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045179">
        <property type="entry name" value="YgfZ/GcvT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017703">
        <property type="entry name" value="YgfZ/GcvT_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22602">
        <property type="entry name" value="PTHR22602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01571">
        <property type="entry name" value="GCV_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08669">
        <property type="entry name" value="GCV_T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03317">
        <property type="entry name" value="ygfZ_signature"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="GCV_T" evidence="3">
        <location>
            <begin position="23"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="GCV_T_C" evidence="4">
        <location>
            <begin position="245"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH83110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="322" mass="34555" checksum="82A4CCD2768213FF" modified="2015-07-22" version="1">MNAPSPLLSLPGAVAAEAPDEGVAAHYGDLFREQRALDAGEGFVDLSHRGIVSVSGQDRLSWLHLLLTQHVEALAPGHATEALVLSAHGHIEHALYLVDDGETTWAHVEPGTQKDLIAYLESMKFFYRVDIADRTDDLAVVHLPAGSITEAPEGVTVRETAYGRDLFLPRASLADFAAAAGPPAGVLAYEALRVAAHRPRLGLETDHRTIPHEVGWIGTAVHLEKGCYRGQETVARVQNLGRPPRRLVFLHLDGSEVTLPPHGAAIRLAAEEEGRKLGFVTTSVRHHELGPIALALVKRNVPADAALLADETAAAQETVVEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3J0</accession>
    <name>A0A0F7N3J0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Pyrophosphate--fructose 6-phosphate 1-phosphotransferase</fullName>
            <ecNumber evidence="10">2.7.1.90</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">6-phosphofructokinase, pyrophosphate dependent</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">PPi-dependent phosphofructokinase</fullName>
            <shortName evidence="10">PPi-PFK</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Pyrophosphate-dependent 6-phosphofructose-1-kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">pfp</name>
        <name evidence="12" type="ORF">AA958_06690</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>beta-D-fructose 6-phosphate + diphosphate = beta-D-fructose 1,6-bisphosphate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13613"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="EC" id="2.7.1.90"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="10">Non-allosteric.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer or homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.90" evidence="10"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015301.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_06690"/>
    <dbReference type="EnsemblBacteria" id="AKH81949">
        <property type="protein sequence ID" value="AKH81949"/>
        <property type="gene ID" value="AA958_06690"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_06690"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1396"/>
    <dbReference type="OrthoDB" id="1421302at2"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003872">
        <property type="term" value="F:6-phosphofructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047334">
        <property type="term" value="F:diphosphate-fructose-6-phosphate 1-phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01976">
        <property type="entry name" value="Phosphofructokinase_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022953">
        <property type="entry name" value="ATP_PFK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012003">
        <property type="entry name" value="ATP_PFK_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015912">
        <property type="entry name" value="Phosphofructokinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000023">
        <property type="entry name" value="Phosphofructokinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012829">
        <property type="entry name" value="Phosphofructokinase_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035966">
        <property type="entry name" value="PKF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00365">
        <property type="entry name" value="PFK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000532">
        <property type="entry name" value="ATP_PFK_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00476">
        <property type="entry name" value="PHFRCTKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53784">
        <property type="entry name" value="SSF53784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02483">
        <property type="entry name" value="PFK_mixed"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00433">
        <property type="entry name" value="PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7 10 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PFK" evidence="11">
        <location>
            <begin position="2"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="126"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="170"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="272"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity and substrate specificity; stabilizes the transition state when the phosphoryl donor is PPi; prevents ATP from binding by mimicking the alpha-phosphate group of ATP" evidence="10">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity; stabilizes the transition state when the phosphoryl donor is PPi" evidence="10">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AKH81949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="342" mass="36879" checksum="23F2ED424BF9F690" modified="2015-07-22" version="1">MRVGVLTGGGDCPGLNAVIRAVVRKGVQEYGYEFTGFRDGWRGPLEADTVTLDIPAVRGILPRGGTILGSSRTNPLKVEGGIKRIKENMAKLEVDSLIAIGGEDTLGVAQRLADEYGIKVIGVPKTIDNDLSATDYTFGFDTAVNIATEAIDRLHTTAESHMRVLVVEVMGRHAGWIALHSGLAGGANVILIPEQRFDVEKVCGWVTSRFKASYAPIVCVAEGAMPKDGDMVLKDESLDAFGHVRLSGVGEWLAKEIERRTGKEARTTVLGHVQRGGTPSAYDRWLASRFGLHAIEAVHDEDWGKMVALQGTDVVRVPLSAATARIKTVDPKLYEEVGVFFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3L6</accession>
    <name>A0A0F7N3L6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 17">Aspartokinase</fullName>
            <ecNumber evidence="7 17">2.7.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">AA958_14675</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the phosphorylation of the beta-carboxyl group of aspartic acid with ATP to yield 4-phospho-L-aspartate, which is involved in the branched biosynthetic pathway leading to the biosynthesis of amino acids lysine, threonine, isoleucine and methionine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 17">
            <text>ATP + L-aspartate = 4-phospho-L-aspartate + ADP</text>
            <dbReference type="Rhea" id="RHEA:23776"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 18">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 18">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 1/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5 18">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 1/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 17">Belongs to the aspartokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.4" evidence="7 17"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016580.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_14675"/>
    <dbReference type="EnsemblBacteria" id="AKH83265">
        <property type="protein sequence ID" value="AKH83265"/>
        <property type="gene ID" value="AA958_14675"/>
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    <dbReference type="PATRIC" id="fig|444103.5.peg.3091"/>
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        <property type="reaction ID" value="UER00015"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00461"/>
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        <property type="reaction ID" value="UER00462"/>
    </dbReference>
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        <property type="component" value="Chromosome"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:diaminopimelate biosynthetic process"/>
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        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
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        <property type="term" value="P:phosphorylation"/>
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        <property type="term" value="P:threonine biosynthetic process"/>
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        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04261">
        <property type="entry name" value="AAK_AKii-LysC-BS"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="AceGlu_kinase-like_sf"/>
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        <property type="entry name" value="ACT_dom"/>
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    <dbReference type="InterPro" id="IPR041740">
        <property type="entry name" value="AKii-LysC-BS"/>
    </dbReference>
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        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005260">
        <property type="entry name" value="Asp_kin_monofn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001341">
        <property type="entry name" value="Asp_kinase"/>
    </dbReference>
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        <property type="entry name" value="Aspartate_kinase_CS"/>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000726">
        <property type="entry name" value="Asp_kin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00656">
        <property type="entry name" value="asp_kin_monofn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00657">
        <property type="entry name" value="asp_kinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00324">
        <property type="entry name" value="ASPARTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 18" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="13 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="12 17 20" id="KW-0418">Kinase</keyword>
    <keyword evidence="15" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="11 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACT" evidence="19">
        <location>
            <begin position="268"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="19">
        <location>
            <begin position="350"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="7"/>
            <end position="10"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
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        <location>
            <begin position="174"/>
            <end position="175"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
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        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="210"/>
            <end position="211"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004986"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
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            <dbReference type="ARBA" id="ARBA00005139"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00010122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00016273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
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    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000726-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU004249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="AKH83265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="423" mass="44568" checksum="6D04A94C414E50F9" modified="2015-07-22" version="1">MGLVVQKYGGSSVADAEGIKRVAKRIVETKKAGHQVVVVVSAMGDTTDELIDLAEQVSPIPAGRELDMLLTAGERISMALLAMAIKKLGHEALSFTGSQAGVITDAVHNKARIIDVTPGRIQEAVDKGAIAIVAGFQGVSQDSKDITTLGRGGSDTTAVALAVALEAGVCEIYTDVDGVFTADPRVVKKARKIDRIPYEDMLELATSGSKVLLHRCVEYARRYNMPIHVRSSFSGYPGTWVGNISEGAEGMEHAIISGVAHDVSEAKITVVGVPDKPGEAAAIFRAIADAEINIDMVVQNVSAAATGLTDISFTLPKTDGHRAMELLTKAQPAIGFESLRYDDQVGKISLVGAGMRSHPGVTATFFEALSNAGVNIELISTSEIRISVVTREDVVKDAVRAVHTAFGLDSESDEAVVYGGTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3S9</accession>
    <name>A0A0F7N3S9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Beta-glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_11070</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AKH82681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_11070"/>
    <dbReference type="EnsemblBacteria" id="AKH82681">
        <property type="protein sequence ID" value="AKH82681"/>
        <property type="gene ID" value="AA958_11070"/>
    </dbReference>
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    <dbReference type="PATRIC" id="fig|444103.5.peg.2331"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102483">
        <property type="term" value="F:scopolin beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009044">
        <property type="term" value="F:xylan 1,4-beta-xylosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BXL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006584">
        <property type="entry name" value="Cellulose-bd_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005084">
        <property type="entry name" value="CMB_fam6"/>
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    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
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    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
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        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42721">
        <property type="entry name" value="PTHR42721"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03422">
        <property type="entry name" value="CBM_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00606">
        <property type="entry name" value="CBD_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="SSF51445"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="SSF52279"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CBM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519212" evidence="4">
        <location>
            <begin position="30"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="domain" description="CBM6" evidence="5">
        <location>
            <begin position="846"/>
            <end position="967"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH82681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="967" mass="104150" checksum="B518A8AD133C81E1" modified="2015-07-22" version="1">MHRRTVLAASLAVPLSGPLATALAGTAAAATPHAPGAAAAARKVRELLGKLTLDEKISLLHQWQPAIPRLGMKAFRTGTEALHGLAWLGPATVFPQAIGLASTWNPDLIREVGEAVGDEVRGLQHERPAGWGLNVWAPTVNLLRDPRWGRNEEGYSEDPYLTGVISTAYAGGMSGGDPDNLKTAPLVKHYLANNNEVRRSETSSDLRPRVLKEYEEPAYRAAISADAACGVMTAYNLVNGRPCTVTDLNASVRTWTDRALLNVTDAWAPNNLPATGSQKYFDTLAEADAAILKAGVDSFTTDDTNGKPTADAVKEALAKGMLTEADIDTAVRHILDIRARLGDFAEDGGPYGHLDKSVIDSPAHRKLARRTAAEAIVLLKNDGALPLDAEALRKVAVVGPLADTLYTDWYSGELPYAITPLKGITDHLGAGAEVTTSEGVDRIALKNAATGRYVSAGSGAEGAALTESATEAGETEQFDVFGWGEGIVTLRALANGKVVGLRDGQFFNDQDQPNGWFVSQLFRPEEQDDGTVVLRYAGYEDWFGDAVYLRAREDGVLVLGTAAQASRYTLETLRDGIDEAVAAARAADTAIVVVGSMPFINARETDDREDMGLAGTQSALVRAVLAANPKTVVVVENSYPTTLIWEQEHVPALVWTTHAGQETGRALADVLFGDVNPAGRLTQTWYRSAAGLPSILEYDNIKYERTYQYFTGDVLYPFGHGLSYTTFRYGRPRLLRDAVAVPVTNTGSRAGAEVVQLYTRQRDSRVKQPLKKLQAFAKVTLRPGETRTVTLPLPRAALAHWDVTRERWVVERSTYDVLVGASSGDIRARAELDVDGETVPPRDLRRTTRAENFDDYAGVRLVDESKPRGTAVAAESAGAWLLFADADLRRGARRLVARVAKESPGAVTLEVRLDAPDGPLAGEAAVRSTGSQYAYEEVTATLRGATGRRDVYLVPGEGVRIADFSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3Z3</accession>
    <name>A0A0F7N3Z3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH tetR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_15325</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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        <property type="molecule type" value="Genomic_DNA"/>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH83355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="281" mass="30367" checksum="D31CFB23F811B735" modified="2015-07-22" version="1">MASVRRKVRGARVSIWLTGRANVRRRGYAPAAGEAGLDLGKIVAATVRLLDAEGLGRLSMRRLAAELGVTAMSVYWYVDTKDELLELALDHAYAELDLPAEDGGDWAAQLRQLAHEHRRILVAHPWVSRLAGEYLNVGPHAMACVAAAQRAMRRAGLPEECLTGGLSLLFPFSYGFGGVGGRLAELGEDYGAFVRALREQPECVRPPAARSPVPDQPVPEGPEAPEALEAPEAPEAPDLPVLPAHEQRDRDFAFALECVLAGMAAMRDRVAEQVRPTITPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
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    </gene>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
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    <dbReference type="EnsemblBacteria" id="AKH82128">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <location>
            <begin position="35"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="280" mass="30834" checksum="662C27F975D97C9F" modified="2015-07-22" version="1">MEPWEHGRAVDAAQATAAELGLRADDTVVIHNSDRVVLRLLPCDVLVRVAPSEHLADSRFEVEVACRLADVDAPVAGLEPRVDPRVYVHGAFAVSLWRYYEPVGAEIAPADYADALVRHHAALRRIDLDAPHFTDRVAGALREVNDTERSPELPDADREFLRSTLSGLSAAISAGSSGDQLLHGEPHPGNLLNTRRGPLFVDLATCCRGPVEFDLAHAPEDVGKHYAGADPALIHRCRALGWAIFSAWRWRQEDQMPDRAHWRTAGLQRVRTALERRGPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N440</accession>
    <name>A0A0F7N440_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Carbonate dehydratase</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="11 12">
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        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
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    <dbReference type="PATRIC" id="fig|444103.5.peg.994"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
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        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
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        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF55008"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="107"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="363"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="389"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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            <end position="722"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="728"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="10">
        <location>
            <begin position="11"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="73"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AKH81612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="755" mass="77746" checksum="A06627C6D0962F99" modified="2015-07-22" version="1">MTTTTPGRTAEVELAIGGMTCASCAARIEKKLNRMEGVEATVNYATEKAKVTFAGDVAVDDLIATVERTGYTAAPPAPAGQDAGDGTADGTGGQGPPDELRTLRQRLFGSLALSVPVIAMAMVPALQFEYWQWLSLTLAAPVVVWGAWPFHKAAWTNARHGAATMDTLISVGTTAAFLWSLWALFFGTAGEPGMTHPFELTIARGDGSGNIYLEAAAGVTTFILAGRYFEAKSKRKAGAALRALMELGAKEVAVLRDGREERVPVDLLAVGDRFVVRPGEKIATDGTVVEGTSAVDASMLTGESVPVEVTVGDAVTGATVNAGGRLVVEATRVGSDTRLARMARLVEDAQNGKAAVQRLADRISGVFVPVVIALSLGTLGFWLGTGDGIAAAFTAAVAVLIIACPCALGLATPTALMVGTGRGAQLGILIKGPEVLESTRKVDTVVLDKTGTVTTGTMTLHALHTAGGEDEETVLRLAGALEHASEHPIARAVAAGATDRLGTLPVPEDFANVPGLGVQGIVEGHAVLVGRQQLLAEWAITLPAGLAAAKERSEQAGRTAIAVAWDGEARALLEVADAVKPTSAQAIKRLRDLGLTPILLTGDNTAVAKTVAAEVGIDEVIAEVLPEDKVDAVKRLQAEGRTVAMVGDGVNDAAALAQADLGLAIGTGTDAAIEAADLTLVTGDLRAAPDAIRLARSTLSTIRTNLGWAFGYNTAALPLAAAGLLNPMLAGAAMAFSSVSVVANSLRLRRFRPLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4C5</accession>
    <name>A0A0F7N4C5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Diaminobutyrate--2-oxoglutarate transaminase</fullName>
            <ecNumber evidence="5">2.6.1.76</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">DABA aminotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_05305</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes reversively the conversion of L-aspartate beta-semialdehyde (ASA) to L-2,4-diaminobutyrate (DABA) by transamination with L-glutamate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>2-oxoglutarate + L-2,4-diaminobutanoate = L-aspartate 4-semialdehyde + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:11160"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58761"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="2.6.1.76"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amine and polyamine biosynthesis; ectoine biosynthesis; L-ectoine from L-aspartate 4-semialdehyde: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.76" evidence="5"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015066.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_05305"/>
    <dbReference type="EnsemblBacteria" id="AKH81712">
        <property type="protein sequence ID" value="AKH81712"/>
        <property type="gene ID" value="AA958_05305"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_05305"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1113"/>
    <dbReference type="OrthoDB" id="386839at2"/>
    <dbReference type="UniPathway" id="UPA00067">
        <property type="reaction ID" value="UER00121"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045303">
        <property type="term" value="F:diaminobutyrate-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047307">
        <property type="term" value="F:diaminobutyrate-pyruvate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019491">
        <property type="term" value="P:ectoine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004637">
        <property type="entry name" value="Dat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012773">
        <property type="entry name" value="Ectoine_EctB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43552">
        <property type="entry name" value="PTHR43552"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43552:SF2">
        <property type="entry name" value="PTHR43552:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00709">
        <property type="entry name" value="dat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02407">
        <property type="entry name" value="ectoine_ectB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH81712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="422" mass="46052" checksum="BCC24A2F3D62B7BA" modified="2015-07-22" version="1">MTITPPALSVFETLESEVRSYCRGWPAVFDRAQGSYLYDEDGHTYLDFFAGAGSLNYGHNNAVLKRALLDYLERDGIVHGLDMATTAKRAFLETFQNVVLRPRDLPYKVMFPGPTGTNAVEAALKLARKVKGREAIVSFTNAFHGMSLGSLAVTGNAFKRAGAGIPLVHGTPMPFDNYLDGQVPDFLWFERLLEDQGSGLNKPAAVIVETIQGEGGINVARADWLRGLAELCKRRDMLLIVDDIQMGCGRTGGFFSFEDAGITPDIVTLSKSISGYGLPMSLTLFKPELDVWEPGEHNGTFRGHNPAFVTATAALDTYWADGQMEKQTLARGAQIEQALVAICAEHSDADTTYRGRGMVWGLEFPDPARAARVCRRAFELGLILETSGPQSEVVKLLPALTTTPDDLDEGLRTLARAVRETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4I7</accession>
    <name>A0A0F7N4I7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">OpcA protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_05640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015121.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_05640"/>
    <dbReference type="EnsemblBacteria" id="AKH81767">
        <property type="protein sequence ID" value="AKH81767"/>
        <property type="gene ID" value="AA958_05640"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_05640"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1181"/>
    <dbReference type="OrthoDB" id="1406083at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004555">
        <property type="entry name" value="G6PDH_assembly_OpcA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38658">
        <property type="entry name" value="PTHR38658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10128">
        <property type="entry name" value="OpcA_G6PD_assem"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00534">
        <property type="entry name" value="OpcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="349" mass="37009" checksum="3C4370D680884186" modified="2015-07-22" version="1">MNIDLTETTSAQINAALVGARRATGTPAVGMVLTLVIVTDEGNHYDALKAASQASKEHPSRILVVIKRPGRSPRERALARLDAEVRVGNETDTGETVLLRLHGELAGHPESVVLPLLLPDAPVVVWWPEDAPENPAEDLLGRLATRRITDAAACEDPVGALRQRATAYAPGDTDLAWTRITPWRSMLAAALDQRHAAIESAVVEGEEYNPSSELLALWLAERLRVPVERTGSPGPGLTAVRLLTTDGVICLDRPNGALAELAVPGQPERHVALKRRTTAELIAEELRRLDPDEAYAQAVAYGVERLAPAGAVEADVAEAEAGAGAAKKAAPKKQPAKKAAVKSSSAKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4P3</accession>
    <name>A0A0F7N4P3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_08975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015686.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_08975"/>
    <dbReference type="EnsemblBacteria" id="AKH82339">
        <property type="protein sequence ID" value="AKH82339"/>
        <property type="gene ID" value="AA958_08975"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_08975"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1890"/>
    <dbReference type="OrthoDB" id="1746185at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="15"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="285" mass="31482" checksum="0E99822A1006DBF2" modified="2015-07-22" version="1">MSAPTVRRRRLGAKLRALRDGRGLTLEEAAEQSGGRITVAKLSRLETARSAAKAVDVEALLDQYEVTDTELRAAVLALTREGARRGWWQSYRGVLSPVYEDLISLEAEAEALYTWQLSVIPGLLQTAEYAREIIGATAMSETVDAKVDALVEVRLARQAVLTRENPLDLWAIIAESALSTQCMGEGVMRDQLARLHLLSKRPNISIQVLPTDSPPHVGQLGSFSVLSFEGHRDLDVAHSESLTSFVYFEDQEQVSAYRDAISRLRDAALPVEVSAERIAEKRDQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4V7</accession>
    <name>A0A0F7N4V7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_13280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016372.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_13280"/>
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        <property type="gene ID" value="AA958_13280"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_13280"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2794"/>
    <dbReference type="Proteomes" id="UP000034283">
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    </dbReference>
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        <property type="entry name" value="DUF3027"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11228">
        <property type="entry name" value="DUF3027"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH83041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="304" mass="31787" checksum="9D8500E68BFE9E60" modified="2015-07-22" version="1">MSPANSPAKTTAVRGAAVRSRVTPDQQCADAVDLARAAAEEAAGAEQVGEHIGVTADDTRVVTHLFECRLPGYRGWRWAVTVARASRARTVTLDETVLLPGPDALLAPEWVPWHERLRPGDLGPGDLLPTEDQDLRLEPGLAVGDEELEPAEAEERAVAGEAAAEGAEGAGMEARPVAAAAPPGGVPRRAEIGALADELGMTRHRVLSRYGLHTAADRWEDEYGPKTPMAQAAPASCVSCGFLMPIAGSLRRAFGVCANEFSPADGHVVSLAYGCGGHSEAAVMPKPIEPAPPVLDTMGADPTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4Y2</accession>
    <name>A0A0F7N4Y2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_13435</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83066.1"/>
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_13435"/>
    <dbReference type="EnsemblBacteria" id="AKH83066">
        <property type="protein sequence ID" value="AKH83066"/>
        <property type="gene ID" value="AA958_13435"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_13435"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2825"/>
    <dbReference type="OrthoDB" id="1691079at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032808">
        <property type="entry name" value="DoxX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07681">
        <property type="entry name" value="DoxX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="286"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="315"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="345"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="394"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="154"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="418"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="495"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH83066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="577" mass="57621" checksum="AD390998B9E61E01" modified="2015-07-22" version="1">MVRVPSAPTRINVDNPSFRVRLGPSSRRTLAAAGAPLYGGGGYEPALVGAGVGAGAVGAGTVGAGGAGRRRVPVVWTGRVDDTAAGRLLQAIPRGDAGPYPAGGADAAPTQFLPRYDGVTQVLPPMDDATHRLPRIDASGMPPGAAADATQVLPRIPAPSGPYATGHPGAYGPGDGPYDDGQGDYDAPYDLDAGPGGAGAGPGDGRRTQRHGADPVRHAYYPGRRMNLGVVLLPLRIVLGLVSLYAGMGKLSDPLFFDGGEHGSMRSWLERMDPWFIARPLYDFGLAHPVGTGLTVAFLQIIVGVLTICGLWQRLAAAIGGLLALGLLVTVAWQTSSAYDATDALFLAAWSPLVIAGAPVYSLDARLAGEAWRTLGPRSELWELRRRVLRRGTVLATVIVGLALLVGSMLGAAVRSSSTVRVPGPDEPPVNHLPGTPLPATPGGKARGGDAGSATPSRDGSAEPGGEASSPGAAGEPGTEEAGPATESGSVPPEQRQPAAPPASQQAPPPSAENPAPPPSRTGSGADSGTAPAPGAGAPESGADGEGSTGGGGSPGGGSTGGGGEEKPKGLVGGLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5G4</accession>
    <name>A0A0F7N5G4_9ACTN</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_14975</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016621.1">
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH83306">
        <property type="protein sequence ID" value="AKH83306"/>
        <property type="gene ID" value="AA958_14975"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_14975"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3156"/>
    <dbReference type="OrthoDB" id="2011619at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004155">
        <property type="entry name" value="PBS_lyase_HEAT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03130">
        <property type="entry name" value="HEAT_PBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00567">
        <property type="entry name" value="EZ_HEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH83306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="281" mass="31147" checksum="E06A0579944ED8E8" modified="2015-07-22" version="1">MNWWKKLRTALAGGDKHTGPWCDACRRRVPGGVTKAPPPGVLSPSFYVGAPGRVGSTVVREACDDCWRRHRELTAEGEADYRRTHPVEKYVAALRDRDLSVREDAARVLMTLRDPRAVAPLIAAIRSETDHPRVERSYYVSALMFALADTGGEEARDFLDGLLRAPASWRELHRPDFYPLIPAVDWVAPALAVPGDTVMLRPLLDLLAEDRPVPVRRGVAQHLARLTNGGAGRWSVDGPVVCEITPEGRRMFTEGMRAAADDADETVRRYVTRALAHVGAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5H1</accession>
    <name>A0A0F7N5H1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_10890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015989.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_10890"/>
    <dbReference type="EnsemblBacteria" id="AKH82649">
        <property type="protein sequence ID" value="AKH82649"/>
        <property type="gene ID" value="AA958_10890"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_10890"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2291"/>
    <dbReference type="OrthoDB" id="1644255at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027843">
        <property type="entry name" value="DUF4440"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14534">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4440" evidence="1">
        <location>
            <begin position="24"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="138" mass="14683" checksum="1705EFC39302765A" modified="2015-07-22" version="1">MTTHPRPGHAGSLRPYEAEQLPYAFAAAFNSGSPETLSRIYADDAVFVPRPGTCVSGRELVAANTEFQALGVPIRVEPRQVYATGDTALLVVDWVLDGKGKDGAHVRIEGTATDVARRGADGVWRYVIDNPFGTAAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5M2</accession>
    <name>A0A0F7N5M2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_07615</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015472.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH82122">
        <property type="protein sequence ID" value="AKH82122"/>
        <property type="gene ID" value="AA958_07615"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_07615"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1598"/>
    <dbReference type="OrthoDB" id="1204683at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="6"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH82122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="210" mass="22062" checksum="891CBA71C3A641BD" modified="2015-07-22" version="1">MARPREFDEEAVLDVAREQFWTKGYAGTSMDAIAAATGLGKGSLYGAFGGKKQLFLRIFDTYCARIADAMASGLTGPDDQAYARLCAHIRAAAAGVAADKRHHGCLLAKGAAELSEHDPDVAVRARRTLEGIATTLAEDIRAAQRHSDLDPAADADQLATLVVAVLRGIEALGKAGIDADRLESVAETAIGLLPRTGKARDLAMPTGSVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5P3</accession>
    <name>A0A0F7N5P3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fe-S cluster assembly protein HesB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_15245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016660.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_15245"/>
    <dbReference type="EnsemblBacteria" id="AKH83346">
        <property type="protein sequence ID" value="AKH83346"/>
        <property type="gene ID" value="AA958_15245"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_15245"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3211"/>
    <dbReference type="OrthoDB" id="1701968at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017658">
        <property type="entry name" value="CHP03252_HhH-GPD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03252">
        <property type="entry name" value="TIGR03252"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENDO3c" evidence="1">
        <location>
            <begin position="26"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="206" mass="22115" checksum="7DB0111F3DDFD3CA" modified="2015-07-22" version="1">MNVTVRLAQQPEADALLGRSPLAVLVGMLLDQQVPMEWAFSGPYTIARRMGGDDLDAHAIAAQDPEAFAALLSEKPAVHRYPGSMAKRIQQLCAYLVHEYDGDAEALWRDAGSGRELLRRLQALPGYGKQKAQILTALLGKQYGVTPDGWREAAGAYGDDGSRRSVADITGPETLTEVRAFKQEAKAAAKAAGAQGKTGRKAKKPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5P6</accession>
    <name>A0A0F7N5P6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_18785</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017202.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH83905">
        <property type="protein sequence ID" value="AKH83905"/>
        <property type="gene ID" value="AA958_18785"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_18785"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3944"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH83905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="111" mass="12336" checksum="AB632F38F8C1B65B" modified="2015-07-22" version="1">MAPAIDAHVRLDAHPTHPTAVTADLPGDQAHIALTALRSANWTVVTAHGLVLARIDRDEPCWAKDAARHLIAEGITVEITPRLQEAIDEEWNWPDYPRTPRARCWPNSPKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5Y2</accession>
    <name>A0A0F7N5Y2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_11840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016145.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH82809">
        <property type="protein sequence ID" value="AKH82809"/>
        <property type="gene ID" value="AA958_11840"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_11840"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2489"/>
    <dbReference type="OrthoDB" id="2055010at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH82809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="165" mass="18082" checksum="99F687A3A1843527" modified="2015-07-22" version="1">MEDVRVRLAAAADRAVLERLWLMCCHDMTEFGGQLPDPDGTFQSRTIRTALTGPGWIAYLLTLRGRPAGLALVEVLSGPTHVLSAFFVVRGVRRSGVGLRAVRQIVARHPGPWGVAFQDGNPAAGCFWRRVAAEVAGDAWVEERRPVADRPEVPPDVWISFNARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-08-12" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6G3</accession>
    <name>A0A0F7N6G3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Anti-sigma factor antagonist</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_12955</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the anti-sigma-factor antagonist family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016317.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH82983">
        <property type="protein sequence ID" value="AKH82983"/>
        <property type="gene ID" value="AA958_12955"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_12955"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2727"/>
    <dbReference type="OrthoDB" id="1864829at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043856">
        <property type="term" value="F:anti-sigma factor antagonist activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003658">
        <property type="entry name" value="Anti-sigma_ant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13466">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00377">
        <property type="entry name" value="ant_ant_sig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="3">
        <location>
            <begin position="2"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH82983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="135" mass="14095" checksum="31F64F818DC09899" modified="2015-07-22" version="1">MLQVTTDNRGDWYVLWVCGELDLVTSPRVRQRVHDAVAEGRRRLVLDLSAVRFCDSSGVGVLIAARRLLSSCGGEFRLILPADGGVGASGGVSGTAVSGGAHVNRVLAALGVRRLFAVYADVDDATSGTAEPLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6H7</accession>
    <name>A0A0F7N6H7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Peptide ABC transporter ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_17340</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016985.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_17340"/>
    <dbReference type="EnsemblBacteria" id="AKH83681">
        <property type="protein sequence ID" value="AKH83681"/>
        <property type="gene ID" value="AA958_17340"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_17340"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3646"/>
    <dbReference type="OrthoDB" id="1303270at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="12"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="268"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="54"/>
            <end position="61"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH83681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="330" mass="35504" checksum="EBD93C36DC6C84F6" modified="2015-07-22" version="1">MSTTRTSPEALLHIRDLHAGYTVPGRSGLGRRRVDAVAGVDLTVRPGQTVCIVGESGCGKSTLARSVVGLLEPFAGSVSFAGLDLATAGRRERRRVAHDLQMVFQDPYTSLNPRMRVAEIVAEGWHIHRDVVAPAEHATEVARLLTQVGLDASYATRRLHELSGGQCQRVSIARALALRPKLIVCDEAVSALDVSVRAQILNLLADLQRELGIAYLFISHDLDVVRHIADEVAVMYLGTIVERGTAAQVFESPQHPYTQALLKAAPSVRDRPGAAKDLPLTGEVPSPSSPPTGCRFRTRCPLAADICESEAPELRVRDGGDHPAACHFAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6K6</accession>
    <name>A0A0F7N6K6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_13190</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016360.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_13190"/>
    <dbReference type="EnsemblBacteria" id="AKH83028">
        <property type="protein sequence ID" value="AKH83028"/>
        <property type="gene ID" value="AA958_13190"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_13190"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2776"/>
    <dbReference type="OrthoDB" id="1688876at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519188" evidence="2">
        <location>
            <begin position="31"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH83028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="338" mass="35864" checksum="667DE71F072F3F57" modified="2015-07-22" version="1">MRAHRLPTAAALLTAAAVATSAAYAPPAAAQDDVILTDPRITESSGLAASRQHENVYWTHNDSDDGPYIYAVDGGTGETLATITLRGIGEPRDVEAISLGPGNQLYVGDIGDNMDGSWSYVWIYRFPEPRQLQDATVDAVQYEAQYEDGPRDAEALMVHPKTGRVYLVSKKQNGGAALYAGPEELSPGSMNIFERVAPVNLWVTDGAFSPDGTRLALRSYVGGRMYRFENGKPEEDGRLDVPLQRQGESMTYTADGSAIVFGSEGEQSDLIRREVEGGGSSSEPGGSGDGSGDDSGDGASGAGDDEDRDPVKTVLLVGGGIGAVLLLRRVLSKRPRPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6P9</accession>
    <name>A0A0F7N6P9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphoserine aminotransferase</fullName>
            <ecNumber evidence="6">2.6.1.52</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Phosphohydroxythreonine aminotransferase</fullName>
            <shortName evidence="6">PSAT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">serC</name>
        <name evidence="8" type="ORF">AA958_13170</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>2-oxoglutarate + 4-(phosphooxy)-L-threonine = (R)-3-hydroxy-2-oxo-4-phosphooxybutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:16573"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58452"/>
            <dbReference type="ChEBI" id="CHEBI:58538"/>
            <dbReference type="EC" id="2.6.1.52"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 6">
            <text>2-oxoglutarate + O-phospho-L-serine = 3-phosphooxypyruvate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:14329"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:18110"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57524"/>
            <dbReference type="EC" id="2.6.1.52"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
        <text evidence="6">Binds 1 pyridoxal phosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 6">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 2/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Cofactor biosynthesis; pyridoxine 5'-phosphate biosynthesis; pyridoxine 5'-phosphate from D-erythrose 4-phosphate: step 3/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 6">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.52" evidence="6"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016356.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_13170"/>
    <dbReference type="EnsemblBacteria" id="AKH83024">
        <property type="protein sequence ID" value="AKH83024"/>
        <property type="gene ID" value="AA958_13170"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_13170"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2772"/>
    <dbReference type="OrthoDB" id="996960at2"/>
    <dbReference type="UniPathway" id="UPA00135">
        <property type="reaction ID" value="UER00197"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00244">
        <property type="reaction ID" value="UER00311"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004648">
        <property type="term" value="F:O-phospho-L-serine:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008615">
        <property type="term" value="P:pyridoxine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00160">
        <property type="entry name" value="SerC_aminotrans_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022278">
        <property type="entry name" value="Pser_aminoTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006272">
        <property type="entry name" value="Pser_aminoTfrase_mycobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000525">
        <property type="entry name" value="SerC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01366">
        <property type="entry name" value="serC_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-0664">Pyridoxine biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0718">Serine biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="7">
        <location>
            <begin position="32"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="6">
        <location>
            <begin position="79"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="6">
        <location>
            <begin position="247"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="6">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH83024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="372" mass="39750" checksum="293B9792A37AACCF" modified="2015-07-22" version="1">MAEIVIPDDIKPADGRFGSGPSKVRTEALEALAATGSSLLGTSHRQAPVRDLVGRVRDGVRALFSLPEGYEVVLGNGGATAFWDVATHGLIERKSQHLSFGEFSSKFAKAAKLAPWLDEPTVVSSEPGTHPEARAEAGVDVYALTHNETSTGVAMPLRRVEGADDEALVLVDATSGAGGLPVDVAETDVYYFAPQKSFASDGGLWIAAFSPAALERAARVHASGRHVPEFFSLPTAIDNSRKNQTYNTPALTTLFLLAEQLDWINGQGGLDWAVRRTAASARTLYNWAEEAKAATPFVADPAQRSAVVGTIDFSDDVDAAAVAKTLRANGIVDTEPYRKLGRNQLRIAMYPAVDPADVEALTRCIDHVIERI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6Q0</accession>
    <name>A0A0F7N6Q0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_13470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016403.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_13470"/>
    <dbReference type="EnsemblBacteria" id="AKH83073">
        <property type="protein sequence ID" value="AKH83073"/>
        <property type="gene ID" value="AA958_13470"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_13470"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2833"/>
    <dbReference type="OrthoDB" id="1697679at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519309" evidence="2">
        <location>
            <begin position="28"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH83073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="243" mass="23872" checksum="EF9ECCC97B64C173" modified="2015-07-22" version="1">MSSSSIRRGTLAATALALSLAALTACGAGNNAETLKINPDNARVTAGSIKIQNAVVITPADEADGPAAVSARIFNNGDRDQTLERLTLADGGQELELSGANGRGGVVVPAGGSVMLGGEGHASAVLPDGHDAGHGATKKLAFEFSREGEVRLAAFIVADDGEYAPWAATPTPTPVETGTSSPDAEPGEDAGTGTDATEGAEGGAAGADATDGASPDADATENAVEGTDATEGATSSESPVTEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6W0</accession>
    <name>A0A0F7N6W0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Asparaginase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_13705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_13705"/>
    <dbReference type="EnsemblBacteria" id="AKH83113">
        <property type="protein sequence ID" value="AKH83113"/>
        <property type="gene ID" value="AA958_13705"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_13705"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2885"/>
    <dbReference type="OrthoDB" id="1434447at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010349">
        <property type="entry name" value="Asparaginase_II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42110">
        <property type="entry name" value="PTHR42110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06089">
        <property type="entry name" value="Asparaginase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="342" mass="35954" checksum="BC94892BE3C258FC" modified="2015-07-22" version="1">MHDDTWIHPPPVPGPAATEEGANADAAPVLAEVVRSGFAEGRHRGSLVLLDPDGEVERAWGNVTGQVFPRSSNKPFQAVAVLRAGARTDAGPLAAERLALAAASHSGERFHLDLVRKMLAGTGLSEDDLRTPPDLPLDPEEREAYLAAGGRRDRVAMNCSGKHAAMLAACVANGWPRASYLAAEHPLQRLVRQVVEETAGEEVRHVGVDGCGAPLMSLSLTALARGFRRLVLAAEGTPERRVADAMRAHPEYVAGTRRWDTWLMRGVPGALAKVGAEGVQAVALPDGRALAFKVDDGALRAVGPVLARGLALLGVRSPVLARIGAAPLLGGGEQVGEIRATF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6W8</accession>
    <name>A0A0F7N6W8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thiamine biosynthesis protein ThiF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_10420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015914.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_10420"/>
    <dbReference type="EnsemblBacteria" id="AKH82572">
        <property type="protein sequence ID" value="AKH82572"/>
        <property type="gene ID" value="AA958_10420"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_10420"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2194"/>
    <dbReference type="OrthoDB" id="1408716at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008641">
        <property type="term" value="F:ubiquitin-like modifier activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="PTHR10953"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="SSF69572"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ThiF" evidence="1">
        <location>
            <begin position="129"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="375" mass="39640" checksum="E276D5EB3EB510D1" modified="2015-07-22" version="1">MAVGEWARPRVKPEHRGYRTVAGNVRIGSVIYGVGAEIEDPRGWVWTLVEAADGSRSTRDIVTAVRARHEEIEPGDVTAALERLAAAGFLEDAAAPLPARFSPREAERYSRGVPLLRWMDLGARASAWEAQLRLKEARVLVLGVGGTGGAAAWHLAASGVGHLHVVDDDRVELSNLNRQLLYAEADLGRRKAEAAVARLAALNPDIRVTGEVRRIATAAELAALVVSSPPYDVFVLGADGPPQIRRWANRACLAAGLPWVDGGYSGPLVTAGVHRPGTGGCWECLHDQARQRADLGLAPGADEPGTSAHLPWNPANAVTAGLSGALVAYGALALLTGIPPLEPGVRFGFNLMVPGDEVTVRLPRRPDCPACGGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6Z8</accession>
    <name>A0A0F7N6Z8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_21550</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017617.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_21550"/>
    <dbReference type="EnsemblBacteria" id="AKH84355">
        <property type="protein sequence ID" value="AKH84355"/>
        <property type="gene ID" value="AA958_21550"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_21550"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4538"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1045"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="62"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="530"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="831"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="979"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1071"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="632"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="731"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1006"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1098"/>
            <end position="1126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH84355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="1280" mass="127662" checksum="6DB823BEA07581C0" modified="2015-07-22" version="1">MDDYAGRVLADRYRLPAAVDAEPIHTRAFDTYSGQDVLIGQVPLPEIVEAEFIEDGGGADPSGYGDGAGRGAASAVVQRAMDAARAAAAIPDHPRLAQVFDVFEEGGSLWIVSELVPARTLEGLLEERPLSPYRGAEVAADILTALRALHAHGWTHRNITTRTVLVCDDGRVVLTGLASGAAEEALCGYDPLPPPPGRGEPPRPSGSPGPRPGVTAEQAAGAEPGPGDAPGLPQLPDPATGFLPAQGAPGAPRGAVGGPEGGILPPGWDDRGGPYGDSAEARGGAGPYGTPPYDEDDEVWRSAPYGAGRGTDPAEDEPRGGDGREPGWGAPGGSATGAGTGEAAAEGWPFGAWQQGGPAAGATGGERGGPQGGHPGGGAAGTPGQRPGVPGGGPAQQAQRSGAQSGGGAPVARGQGSGAPGVGPAQRPYAGGAQGGAAQGAPGGQPGGGPAGARGQGPAVPGGGPVQQPYGSGPQGGPPAGQGPRGAGPAPREGQSGGRPVPAGGGDVPAARAGVMAAYQAGTRAAEARIAGGAGGARPPVVPGQAARTPEAGRPPGAGAGPAYSDRIDIGGGPPAQGGAANPAPQTAGSPDTGAPWDDLPHDAGDDGYDEYGTADPYGTRTAAPGGPYRSTGAPPGAPAPHAGGPVPPGAPGSGGAPGAPVPGRAPGATGAPGSYGSGPPGGAPAGGAPGPYRGTGAPGAHGGIGSGSYDHSGPAYGGPGTAAGTPAPGGPPASRGPGPGPAPGGAAPGHHHPTDRARPPGAPGGHPAAGQPGGRGPGAYGTPGARPAEFAEPEQQSLPDSLPGGASYGGSLPGVRPGASIAVPVGAQAVPADRDAPPGPEAGGATRYPGPSTRLAAERARTTRMQVVGAVTERWAPEQAGPVHEHWQLAPPVGPAADLWALGALLFRAVQGHSAYPEEDVAELVQLVCSEPPAHAEECGALRPVVESLLRQDPTERPDFEELRGWLRSLIRTAPEPGIGSRTVTVPQHGTGRGGDPRRLPILRRRGELMRRRRANKSPVPVRKRHKRRARRGPRGPRSLGRTLIALIFVAMAGAIAYAAMFMPGADEAGRDQRSAVGAGRGDEPGEPAAPPSDSDDTSEAGERGQPKESGDAPDKPKDDGQGSGEGSELPDGFVLREDPAGFEVAVRDDWQRTAGSDGQVSYVGGDYELLVVPGRDGVGEFGSDPMAYQQQSEPELDEYRDSAWAQADGLRRIEVGQRVMAEGEFDWTDGSGRQVHARNLAMIWDDHYHVVLLIGPDGKNDEVERFHRIAAESYRPTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N729</accession>
    <name>A0A0F7N729_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_21795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017652.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_21795"/>
    <dbReference type="EnsemblBacteria" id="AKH84390">
        <property type="protein sequence ID" value="AKH84390"/>
        <property type="gene ID" value="AA958_21795"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_21795"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4590"/>
    <dbReference type="OrthoDB" id="957193at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13632">
        <property type="entry name" value="Glyco_trans_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="84"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="291" mass="31980" checksum="AFA4DE55EE1E42B0" modified="2015-07-22" version="1">MSVPRLGVAVLTMGTRPAELAALLESVAAQSVPAARVVVVGNGCRLPDLGGGVTAVELSDNLGVSGGRNVAIKELRAFGDVDVVVDLDDDGLLVDEEVFARLRDHYAADERLGVVSFRIADASGATQRRHVPRLRSGDPMRGGEVTTFLGGGHALSMRMLDEVGTWPGHFFFTHEETDLAWRALDAGWKVVYDPELLLQHPKTSPARHAVYYRMTARNRVWLARRHLPLPLVPVYLGTWLALTLARVRSAAGLRAWFGGFTEGMRTDCGGRRPMRWRTVWRMSRLGRPPVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N749</accession>
    <name>A0A0F7N749_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_14385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016539.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_14385"/>
    <dbReference type="EnsemblBacteria" id="AKH83223">
        <property type="protein sequence ID" value="AKH83223"/>
        <property type="gene ID" value="AA958_14385"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_14385"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3027"/>
    <dbReference type="OrthoDB" id="880746at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="395" mass="43673" checksum="F8EEECBB3865D481" modified="2015-07-22" version="1">MKLIGDGSTAYTGSQPNQPKISRMSAGTKPPQFVVFSWDGAGEDGQRLFSHFRKVARENDAAMTYFLSGVYVLPRDKRMEYQPPGHARGASDIGYLDEEEVAATLEQVRGAWLEGSEIGTHFNGHFCGRTGVASWSKEDWKSEIAQAKQFVQRWKTNTGRKKADPLPFDYDKELVGGRAPCLEGQKNLMKASKEMGFRYDTSGVGSQVWPKKKEGIWDLSLQEVPFPGRAFEVVSMDYNFMANQSGTAYAPAAQHAAFERQMREGLLAGFERAYTTNRAPLVIGNHFESWNGGAYMRAVEDTIKTVCPKKDVHCVSFRQLVDWLDAQDPAALARLRTLDVGEQPAQGWEKFLVKEAKDTKNAKDAKKGSAQRAEPAGSGEKDHAGTTDAKEGQAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N759</accession>
    <name>A0A0F7N759_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH tetR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_14450</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016549.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_14450"/>
    <dbReference type="EnsemblBacteria" id="AKH83233">
        <property type="protein sequence ID" value="AKH83233"/>
        <property type="gene ID" value="AA958_14450"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_14450"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3041"/>
    <dbReference type="OrthoDB" id="1437290at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011075">
        <property type="entry name" value="TetR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16859">
        <property type="entry name" value="TetR_C_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="25"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH83233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="207" mass="22265" checksum="AC9FEB19C418FBA0" modified="2015-07-22" version="1">MPGRPVGQLHGQAPDARIRRPRMTPERERELLEAVLGVLRESGYEALSMDLVATRARCSKATLYRQWHSKAEMVVAAMIANRPVDPGAVDTGSLRGDLISLVEELSSTAEKDTALIAAIHHAALTDGDLAATLHASLADYELTHLSGLLDRAVARGELSGQPGAAEFLPQLLFGAVVIRPLIDGMFADSAYLARFVDLVVLPALRHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-10-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7H8</accession>
    <name>A0A0F7N7H8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HATPase_c domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_11830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016143.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH82807">
        <property type="protein sequence ID" value="AKH82807"/>
        <property type="gene ID" value="AA958_11830"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_11830"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2487"/>
    <dbReference type="OrthoDB" id="1832160at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HATPase_c" evidence="1">
        <location>
            <begin position="33"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="151" mass="16243" checksum="1F98CC0B3A580E5A" modified="2015-07-22" version="1">MTALSTPHPAPPPVTVRMFSQRFSSTPLGARLARHLTIVQLHSWGVPQTATVWDAAAIVAELAANAVTHGRVPGRDFELRLSLLGQVVRIEVSDALGQRRPPGPEQVGAMPVPEGESGRGLLLVEELADRWEVLDRVPVGKTVRAELDLPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7J4</accession>
    <name>A0A0F7N7J4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional activator protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_19585</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017304.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_19585"/>
    <dbReference type="EnsemblBacteria" id="AKH84011">
        <property type="protein sequence ID" value="AKH84011"/>
        <property type="gene ID" value="AA958_19585"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_19585"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4127"/>
    <dbReference type="OrthoDB" id="305074at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022291">
        <property type="entry name" value="Bacteriocin_synth_cyclodeHase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003776">
        <property type="entry name" value="YcaO-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02624">
        <property type="entry name" value="YcaO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03882">
        <property type="entry name" value="cyclo_dehyd_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51664">
        <property type="entry name" value="YCAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YcaO" evidence="2">
        <location>
            <begin position="427"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="646"/>
            <end position="681"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH84011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="726" mass="74144" checksum="1BD8D8ADF3023218" modified="2015-07-22" version="1">MPRAFDDLAAMRPRLRRDVLFTQTPGGVLFHNADGGFHLTGRTAYRFASLIVPHLDGSRPLTDICAGLGAPQRAMVAELVGSLVERDFARDAAPAAEPGPPAAVTERFAAQIAYVDHYVDEAAARFARFRGTRVAVLGTGEAARWCVLGLIRNGLAAVAAEERPEAALAEADELTAAGAPAALDAVDAGALGSYQVLVVTGADAPARTHELLRAGLAEGQLLIPAWTFGDRVVVGPRSGGLTAGCLGCALLRLGDTTDPAAAAALLAELAGVAEPAAVPAGGALTGPVAAMVGNLLAYEVFRTATGALPAETEGQVLIQDLDSLDVVAEPLRPHPRCPRCAEPASGPGADGGSELRPEELTVAEPVTVETARDAEELVAGLNRLGDALIRPHVGVFTRYRDEELTQTPLKVSRIEVPLAGGTRLVSAFDVHHLAGARGRGLRAAAALYAEYAAPVRPLPELPARLRRLEPGALVASGGTGVTADGVTAWARVTSLLTKDEVAVPAAALSPSGAANRDGLVLRGSWGTGAGECAGEAAGHALLSALAHEALLRAARGGHGATPVRAQPTSDDPEWVFLARSAETLGVPVELLDLGEPERSGVSVALAREPGVGARWAVGASFTPAGAAVAALRDLLGQVQVAAETGAAPDTGDELLPDLAPGAIQPSGGDGGDGGDGGPVTFPAVLDRLRAAGRDVLWRDTTPADLRSAGLYTARVLLTTELAGADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7X7</accession>
    <name>A0A0F7N7X7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Purine nucleoside phosphorylase</fullName>
            <shortName evidence="1">PNP</shortName>
            <ecNumber evidence="1">2.4.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_12380</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Purine nucleoside phosphorylase involved in purine salvage.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a purine D-ribonucleoside + phosphate = a purine nucleobase + alpha-D-ribose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:19805"/>
            <dbReference type="ChEBI" id="CHEBI:26386"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57720"/>
            <dbReference type="ChEBI" id="CHEBI:142355"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; purine nucleoside salvage.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homohexamer. Dimer of a homotrimer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="1">Although this enzyme belongs to the family of MTA phosphorylases based on sequence homology, it lacks several conserved amino acids in the substrate binding pocket that confer specificity towards MTA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.1" evidence="1"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016232.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_12380"/>
    <dbReference type="EnsemblBacteria" id="AKH82897">
        <property type="protein sequence ID" value="AKH82897"/>
        <property type="gene ID" value="AA958_12380"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_12380"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2601"/>
    <dbReference type="OrthoDB" id="1364220at2"/>
    <dbReference type="UniPathway" id="UPA00606"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017061">
        <property type="term" value="F:S-methyl-5-thioadenosine phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09010">
        <property type="entry name" value="MTAP_SsMTAPII_like_MTIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01963">
        <property type="entry name" value="MTAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010044">
        <property type="entry name" value="MTAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42679">
        <property type="entry name" value="PTHR42679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01694">
        <property type="entry name" value="MTAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="1" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PNP_UDP_1" evidence="2">
        <location>
            <begin position="10"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphate binding" evidence="1">
        <location>
            <begin position="57"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="1">
        <location>
            <begin position="220"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="1">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="1">
        <location>
            <position position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH82897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="282" mass="29977" checksum="8F0B0DE4FE20434A" modified="2015-07-22" version="1">MAEAAAVQAEIGVIGGSGFYSFLDDVTEIAVETPYGPPSDSLFLGEIAGRRVAFLPRHGRKHHIPPHRINYRANLWALRSLGIRQVLGPCAVGGLQPEHGPGTLLVPDQMVDRTKSRAQTYYDGEQLPDGATPNVVHVSLADPYCPTGRGAALKAAHESGWEAVDGGTLVVIEGPRFSTRAESVWHRAQGWAVVGMTGHPEAVLARELELCYTSMTLVTDLDAGAETGEGVSHEEVLEVFAANVGRLRDVLFDAVGRLPATEDRSCLCAGALAGLDPGIELP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N817</accession>
    <name>A0A0F7N817_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_16700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016883.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_16700"/>
    <dbReference type="EnsemblBacteria" id="AKH83578">
        <property type="protein sequence ID" value="AKH83578"/>
        <property type="gene ID" value="AA958_16700"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_16700"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3513"/>
    <dbReference type="OrthoDB" id="796397at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008557">
        <property type="entry name" value="PhoX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05787">
        <property type="entry name" value="DUF839"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="667"/>
            <end position="686"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="702" mass="74428" checksum="C85AD8ADB574477B" modified="2015-07-22" version="1">MRRLLPLIGSPHPGGRSAMTCRYRCGDACFHEVPNTSDNEYAGDIVARAVSRRGALRAGAAVTVVAAGAQLVGAGPASAAPASPTSPAGTFGRGPGSGGAGGGAARGLRFDAVAPNTDDTVTVADGYEQNVVIAWGDPVLRGAPAFDPARQSAAAQAGQFGYNVDFLALLPLRGERGRELLVANHEYTDEQLMFPGYDPENVTREQAEIGWAAHGMSVVAVQEDGGRGTGGGTLRAVPRHPLNRRITATTAFELRGPAAGGDLLKTSADPTGRRVLGTLNNCAGGTTPWGTVLSGEENFNQYFANAGAVTDPVARQRLARYGLPTGASGRKWEQFDDRFDIAKEPHEPNRFGWVVEIDPYDPDSTPVKHTALGRFKHEGASIRLTRDGRAVAYSGDDERFDYLYKFVSDKRMMRGNSRWARAHNMTLLDEGTLYVAKLTGDSPAGEIDGSGKLPADGEFDGSGEWIKLASGNRSFVPGMTAEEVYVFTRLAADRAGATKMDRPEDVEPSPNSGKVYVALTNNTNRGTGTNAKADEANPRNANKHGHVLELTEKRDDPAATGFGWRLFLICGDPADPSTYFAGFPKDKVSPISCPDNVAFDPYGNLWISTDGNALGNHDGLFGVATTGRYEGQVKQFLSMPTGAETCGPVVQEDRVLVAVQHPGEVDGASYENPGSAWPDGPGKPNRPAVVNVWRTGGGRIGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8B6</accession>
    <name>A0A0F7N8B6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Puromycin resistance protein pur8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_24215</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_24215"/>
    <dbReference type="EnsemblBacteria" id="AKH84805">
        <property type="protein sequence ID" value="AKH84805"/>
        <property type="gene ID" value="AA958_24215"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_24215"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5103"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="249"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="287"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="316"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="351"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="376"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="470"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="29"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH84805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="512" mass="52784" checksum="56CABD97EB268702" modified="2015-07-22" version="1">MATQSADAAAGPGPGAAGAAEPDPKRWLILVVICVAQLMVVLDATIMNLALPSAQEDLGFSLANRQWIVTAYAVAFGSLLLFCGRLVLLFGLKRSFLVGLAGFAGASAVGGAANSFEMLVSARVGQGVFAALLAPATLTLLTTTFTDPKEKGKAFGAYGAVAASGAGLGLIIGGALTSGLSWRWCMYVNLLFAGVALLGAGLPFGRNAAVRSMRTKLDFPGVILVSAAMFCIVYGFSNAANEDWSTPQTWGFLVAGGVLLVAFAAWQTRAAHPLLPPRVVLDRNRSGAYLLMLLVGAGIFGFFLFLIYYMQTTLDYSAIASGVALLPMVVFTAVAVNIGNIKIMPKYGPKPLVIAGLTLNAGALVWLTRVEVDSGYAAALLGPILVLGFGMGFIFAAALQTGTTGVEPQDAGIASASIQVGQQLGGSLGTALLNTIAASAITDYVKEHAQGRPPTEELLQLAAVDSYVTVFWWCAGLFAAGAVICGLLIRSGPLPAPAFGAKPVDKAEKAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8J7</accession>
    <name>A0A0F7N8J7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_24565</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AKH84855.1"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH84855">
        <property type="protein sequence ID" value="AKH84855"/>
        <property type="gene ID" value="AA958_24565"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_24565"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5176"/>
    <dbReference type="OrthoDB" id="2086235at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH84855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="60" mass="6144" checksum="EBC8C3E7BFB02F69" modified="2015-07-22" version="1">MAGAPVICSGQAFAADPRELPIVNRPGHPGAVYASGGLRRAQDEPLNATVDCALSGRRGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8S1</accession>
    <name>A0A0F7N8S1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Betaine-aldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_22140</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_22140"/>
    <dbReference type="EnsemblBacteria" id="AKH84446">
        <property type="protein sequence ID" value="AKH84446"/>
        <property type="gene ID" value="AA958_22140"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_22140"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4663"/>
    <dbReference type="OrthoDB" id="744602at2"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="3">
        <location>
            <begin position="37"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH84446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="480" mass="51154" checksum="6622E3DD97C1E0C8" modified="2015-07-22" version="1">MTAEHKLFAYAPAPESRSVVDIAPSYGLFVDGEFAEAADGKVFKSVAPATEEVLSEVARAGEADVERAVAAARRAFTSWSALPGAERGKYLFRIARIIQERSRELAVLETLDNGKPIRETRDADLPLVAAHFFYYAGWADKLGHAGFGPEPKPLGVAGQVIPWNFPLLMLAWKIAPALACGNTVVLKPAETTPLSALFFADICRQAGLPRGVVNILPGYGDAGAALVAHSDVDKVAFTGSTAVGKEIARSVAGTDKRLTLELGGKGANIVFDDAPVDQAVEGIVGGIFFNQGQVCCAGSRLLVQESVADELLESLKRRLSTLRLGDPLDKNTDIGAINSPEQLARITELADAGDAEGAQRWTAPCELPGSGYWFAPTLFTGVTQAHRIAREEIFGPVLSVLTFRTPAEAVAKANNTPYGLSAGVWTEKGSRILAVADRLRAGVVWANTFNKFDPTSPFGGYKESGFGREGGRHGLEAYLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N948</accession>
    <name>A0A0F7N948_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_19145</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017249.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_19145"/>
    <dbReference type="EnsemblBacteria" id="AKH83954">
        <property type="protein sequence ID" value="AKH83954"/>
        <property type="gene ID" value="AA958_19145"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_19145"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4025"/>
    <dbReference type="OrthoDB" id="237367at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="258"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="284"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="595"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="620"/>
            <end position="640"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH83954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="660" mass="70224" checksum="1B170F15A75BD7A0" modified="2015-07-22" version="1">MSTTATSTSPSSGGGLFGEADFSQERLFRRNLVFFTAATLCMLAGRVLNWWVGTEPWPDVSKAISLIGLSLGIPMFWIALKTLLFERNKLTTEVFITLALVAVVYEEEYWYASWVVFILWLGETLMAWAGRHARNAVEALLKLIPRQARLLTPDGPATVPVEHVRVGQIVEVRPDERIPVDGQIVQGETSVDESMLTGEAVPAEHGVGENVFAGTSNLQGTIQVRATTTVEDNTVAHIVGLMRQAQQAYIPAKRTVDLFLRWFLPLVLLAAAITWFNTGSMDRVAAILLVITPCAFSASTPLALIATVGAAARRGLVIKGGAAIEACSRAKVVLLDKTGTLTAATPQLTTIDAFGSHSEAEVLQLAAIAEKHSTHPLARAVGAAAAERGLKVEDPEDFEVASGHGVTATHAGRRLTVGNERFLDRTNIAIPGPVRARAAEREAAGHTLAYVLCDGTVIGLLGFLAQPRGNAAAVIGGLRKLGVQHVVMVTGDRSSPAQAVASQLGIDYHSQATPEDKLAEVQRWQDQGYVVAMVGDGINDSTALAKADVGVAMVGAGAEVAALAADIVVHGDHLSRVLTVARLCRRGIRTIQLNIFFATVYNIVGLILALYGLISPGTAVLFHAASFISVVLNSATVLLYRPKDVSDTPPTRSPELTPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9C8</accession>
    <name>A0A0F7N9C8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">XRE family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_20225</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017412.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH84123">
        <property type="protein sequence ID" value="AKH84123"/>
        <property type="gene ID" value="AA958_20225"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_20225"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4259"/>
    <dbReference type="OrthoDB" id="1292067at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="25"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH84123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="204" mass="22249" checksum="ED31B8AD6D0BA50D" modified="2015-07-22" version="1">MTDTDSAPDPDGEPGTALTAVGPRMRELRRQREQTLAELSAATGISVSTLSRLESGSRRPTLELLLPLARAHGVTLDELVGAPPTGDPRINLRPVTRNGMTMLPLSRRAGGIQAFKLILPAGSGRREPDLRTHEGYEWMYVMNGRLRVVLGEHDLILEPGEAAEFDTRVPHWFGAADDEPVEFLSLFGGQGERAHLRARPKSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9H8</accession>
    <name>A0A0F7N9H8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glutamate ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_26555</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AKH85200">
        <property type="protein sequence ID" value="AKH85200"/>
        <property type="gene ID" value="AA958_26555"/>
    </dbReference>
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    <dbReference type="PATRIC" id="fig|444103.5.peg.5588"/>
    <dbReference type="OrthoDB" id="1191583at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030679">
        <property type="entry name" value="ABC_ATPase_HisP-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039085">
        <property type="entry name" value="ABC_ATPase_HisP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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            <end position="253"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="51"/>
            <end position="58"/>
        </location>
        <ligand>
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        </ligand>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH85200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="259" mass="28195" checksum="9219B384C32A8049" modified="2015-07-22" version="1">MTEVSTAKDAVPAAGEPLVVLDNVNKHFGALHVLQDIDLTIARGEVVVVIGPSGSGKSTLCRAINRLEPIDSGRITLDGKPLPAEGRELARLRADVGMVFQSFNLFAHKTVLQNVMLGQIKVRKKDKAAAETSARALLDRVGVGNQADKYPAQLSGGQQQRVAIARALAMEPKVMLFDEPTSALDPEMINEVLEVMQQLARDGMTMVVVTHEMGFARSAANRVVFMSDGQIVEETTPDQFFTNPRSDRAKDFLSKILHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9V1</accession>
    <name>A0A0F7N9V1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_24345</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A0F7N9V1"/>
    <dbReference type="STRING" id="444103.AA958_24345"/>
    <dbReference type="EnsemblBacteria" id="AKH84821">
        <property type="protein sequence ID" value="AKH84821"/>
        <property type="gene ID" value="AA958_24345"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_24345"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5130"/>
    <dbReference type="OrthoDB" id="816674at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH84821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="392" mass="43816" checksum="DF69BB4CF31806A4" modified="2015-07-22" version="1">MAVEYSPYDEQLNVDPYPLYAQLREKAPVYHNEELDIWALSRHADVDAALRDSAGFSSANGPLLDSAIWGPDAHKVMSFNAMDPPDHTRTRALVSGVFSPRHMNGLEERIRDIVRTHLDPALERESFDFVADVAATVPMDVISELIGVPHEDRAEARRLIHLAFHRPPGARDLTPENAQAMGELAGYYLRWVSERRRTPGTDLLTSLGQARPDGALLTDEQIVAVLGLLVTAGYETSLRMLGNAWYWAWRNPDQRARAFDGGITEWVEETLRYDTPVQYMVRTLTEDRTLHGVPVPAGARVLCLIAAANRDPEVFPDAERFDLGRDTHRVISFGGGPHYCLGAPLARLEARVVLAELARRVSAYEIDADRAVRVYTTNIRGFSSLPTTIKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NA81</accession>
    <name>A0A0F7NA81_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_25185</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018207.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH84956">
        <property type="protein sequence ID" value="AKH84956"/>
        <property type="gene ID" value="AA958_25185"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_25185"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5308"/>
    <dbReference type="OrthoDB" id="1968136at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043968">
        <property type="entry name" value="SGNH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19040">
        <property type="entry name" value="SGNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="174"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="285"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="327"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="350"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="388"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl_transf_3" evidence="3">
        <location>
            <begin position="35"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH" evidence="4">
        <location>
            <begin position="459"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF19040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH84956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="700" mass="73880" checksum="E0D8648112E2CCCE" modified="2015-07-22" version="1">MHGQQAPALEAHDPTERRSQPDAQRAAGPGRGFRPDVEGLRAVAVGVVLLYHAGVPLISGGYVGVDVFFVISGFLITGLLVRELERSGRISLTGFYARRARRLLPSTAVVLAAVALLAWLLMSPVERKTVAKDLAAAALYVVNWQQASLAVDYSALGAEASPVQHFWSLAVEEQFYLVWPLLIIAIGWWCTRRGGKAVRPRLAVALGAIAVASFAYSVHLTQQEAGAAYFSTFTRGWELAVGGLVALVPADAWRRLPGRLAGGLALAGLAAIAVAAFGFSDETPFPGSAAALPVLGAAAIIAAGAAAQDTAGAKLLGTAPMRYVGRISYSWYLWHWPAVAFATVKWPGITTAQLAVVVAASWVPAALTHKLVENPVRVSRALAPVGRGLVLGLACTAAGALLGWLTWATVPTMKLADPSQALGAAALQDSTKVQESASVLSPLPEDADADEGAVYGNGCHAGQRDTEAEGCVYGDKKSDTTVALFGDSHAAQFSPALITIAEERGWRLLVLTKSACTPAKVTIYNRQYERDYTECDDWRASAVERIAAEKADLVLVGNRDDQAAMRGGDKLDGDDNTAALRDGMAATLRELKENGADVTAFADIPYPPQDIPSCVSGATDQLTDCAFPLREGLGYEQVTTEAAKRTGVDVIDLGPELCPGGTCPAVIGNVIVYRAGEHITETYMQTLTGWLNDQLPESVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NA88</accession>
    <name>A0A0F7NA88_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GAF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_17005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016931.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH83627">
        <property type="protein sequence ID" value="AKH83627"/>
        <property type="gene ID" value="AA958_17005"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_17005"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3576"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAF" evidence="1">
        <location>
            <begin position="53"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="205" mass="22720" checksum="CE8815D1BC81B82F" modified="2015-07-22" version="1">MTTFDYHTARHLMTDGEQDQELERRKQRLHELGLGDNPDPEFDAFAARLAEGAASLAQLGGTPYAMVNLITDHQYFTGLYAPPAEWADPSLAEQPGKPEVSRVMDRDHGYCPHVVGRRTALVLPDVCAYPRFAGNPVVDQIGIRTYMGAPLIDPVTDVTLGTVCVVDTEPRPWGRQAQEGLEFIKTQARSLMEILEERSRGRAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NA91</accession>
    <name>A0A0F7NA91_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Lysozyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_25240</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 25 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018217.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_25240"/>
    <dbReference type="EnsemblBacteria" id="AKH84966">
        <property type="protein sequence ID" value="AKH84966"/>
        <property type="gene ID" value="AA958_25240"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_25240"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5319"/>
    <dbReference type="OrthoDB" id="1444566at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003796">
        <property type="term" value="F:lysozyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016998">
        <property type="term" value="P:cell wall macromolecule catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002053">
        <property type="entry name" value="Glyco_hydro_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018077">
        <property type="entry name" value="Glyco_hydro_fam25_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01183">
        <property type="entry name" value="Glyco_hydro_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00641">
        <property type="entry name" value="Glyco_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51904">
        <property type="entry name" value="GLYCOSYL_HYDROL_F25_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519429" evidence="4">
        <location>
            <begin position="43"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH84966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="300" mass="32336" checksum="C7001E4B8FBB0B1B" modified="2015-07-22" version="1">MHLPTSLTHRLFTRRAGRTRAGAAVVLGASLALVAGLTAPSAASAPAADSDAKKKNPVPLGHAYMGMGVDAEQSSPDISPMDHTSGVQGIDVSHWQGSINWSSVRSAGIQFAWMKATEGTSYKDPSFNTNYPAAYRAGVIRGAYHFARPNSSSGATQANFFASNGGAWSRDNLTLPGVLDIESNPSGAMCYGLSQTAMRNWILDFYNTYKSRTTRDVVIYTSPSWWNTCTGNWSGMSTRSPLWVAHWTSAHSPSIPNGFPFWTVWQYTSTGRVSGISGNVDRDKFNGSRDRLLALANNTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAD6</accession>
    <name>A0A0F7NAD6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidoglycan bridge formation protein FemAB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_28390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FemABX family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018744.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_28390"/>
    <dbReference type="EnsemblBacteria" id="AKH85510">
        <property type="protein sequence ID" value="AKH85510"/>
        <property type="gene ID" value="AA958_28390"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_28390"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5983"/>
    <dbReference type="OrthoDB" id="891566at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016755">
        <property type="term" value="F:aminoacyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044038">
        <property type="term" value="P:cell wall macromolecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003447">
        <property type="entry name" value="FEMABX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02388">
        <property type="entry name" value="FemAB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51191">
        <property type="entry name" value="FEMABX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="387" mass="42621" checksum="953E42D4116CEAC1" modified="2015-07-22" version="1">MSSSKPGPSLSVRPITAAEHLAFVRRQRSVSFLQTPAWGRVKTEWRSESLGWYDGRGLVGAGLVLHRPVPRLDRFTLAYLPEGPVLDWTGGIDSWLDPLAARLRADGAFAIRLGPPVRTATWNADQVKEGIADPGVTRLTDVSGHWADPVGTRVAGRLRDAGWLPQSPEDGFGTGHPQFKFEIPLAGRTEDDLLAGMNQLWRRNIKKAAKAGVEVTVGERPEDLGAFHALYAHTAERDRFTPRPLGYFETMFAALGAEDPERIRLYLARHRGELVAAAVLVRVGAHAVYAYGASSTAHRDVRGSNACQWAMIRDSLAAGCDVYDLRGITPTLDAGDPHIGLIQFKAGTGGQAVRYVGEWDLPLRPMVYRAFDLYLKTRESRRRRGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAI5</accession>
    <name>A0A0F7NAI5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_22270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017730.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_22270"/>
    <dbReference type="EnsemblBacteria" id="AKH84469">
        <property type="protein sequence ID" value="AKH84469"/>
        <property type="gene ID" value="AA958_22270"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_22270"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4690"/>
    <dbReference type="OrthoDB" id="1361420at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH84469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="227" mass="23643" checksum="28C24DBA7D13D01F" modified="2015-07-22" version="1">MSTAKLTPARRRAVAGADAATGLVRASDRVLEGLVDGGLAVRHPRPPHRHYLTPAGRELRDRLLAVAEAEAEAAAGAGAADEPEGSRVPAEPGVFAARTGGEPAPPDAAARAREVRSAWEGLAELRRLTNADGATDVPCAWERTHLASAVALALEAGGLPPATDVTGGYAVTPAAHQPEAVRVDWRPGPALRELVRAAGVLEAAGWQVSEHPERDGGMYLLASPRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAI6</accession>
    <name>A0A0F7NAI6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_28585</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018779.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_28585"/>
    <dbReference type="EnsemblBacteria" id="AKH85545">
        <property type="protein sequence ID" value="AKH85545"/>
        <property type="gene ID" value="AA958_28585"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_28585"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6022"/>
    <dbReference type="OrthoDB" id="453021at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH85545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="471" mass="49833" checksum="F9DAB36C2ED55502" modified="2015-07-22" version="1">MTTLVDVVVVGAGPNGLTAAVELARRGFTVEVFEARDSIGGGASTTELTLPGFRHDPCSAAHPFGIGSPVFRELPLAEHGLAWVHSELPMAHPFPDGSAAVLSRSVGETATSLGTRDAGVYRRLVEPFLGKWETLSWDFFTASLRSVPRDPVTLLRLGQLAMPASLLNRRFQGVHARGMIAGLAAHAIAPLHTPITAAMALTFALAGHAVGWPVARGGSQAISDALAAYLRELGGEIHTGIEVKRLDELPPARAYVFDTTPTALARIAGLGGAYDGFRYGPSVFKIDYALDGPMPWTSEEARRATTVHVGPTEGEIGAALDAAVNGVAPAVPFLISCQPTIADPTRAPEGKHTFWVYGHVPNGWEGDATEAIERQLERFAPGFRDLVLARATAGPPQLAARNANYVGGDIASGAFSGMQTLMRPRLARVPWATVHPRVFLCSSSTYPGPGVHGMGGHNAARAVFRTLTRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAJ1</accession>
    <name>A0A0F7NAJ1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl-CoA hydratase 2</fullName>
            <ecNumber evidence="1">4.2.1.119</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Enoyl-CoA hydratase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_28630</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3R)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:26526"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57319"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="EC" id="4.2.1.119"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="4.2.1.119" evidence="1"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018784.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_28630"/>
    <dbReference type="EnsemblBacteria" id="AKH85550">
        <property type="protein sequence ID" value="AKH85550"/>
        <property type="gene ID" value="AA958_28630"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_28630"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6031"/>
    <dbReference type="OrthoDB" id="1563802at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MaoC-like" evidence="6">
        <location>
            <begin position="12"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="155"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH85550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="172" mass="19242" checksum="5C2174F9465503EA" modified="2015-07-22" version="1">MQFGRTYEEFEPGAVYKHWPGKTVTEYDDHLFCLLTMNHHPLHLDAHYAGEATDFGRNVVVGNYVYSLLLGMSVPDVSGKAIANLEVESLKHVAPTFHGDTVYGETTVLDKWPSKSKDDRGIVQVETRGHKQDGTLVCVFRRKVMVPTEAYVRERGGEQPGRPEPAGRGGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAT2</accession>
    <name>A0A0F7NAT2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Glycerol-3-phosphate 3-phosphatidyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">AA958_26480</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CNQ-509</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; phospholipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="11">Phospholipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018425.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_26480"/>
    <dbReference type="EnsemblBacteria" id="AKH85186">
        <property type="protein sequence ID" value="AKH85186"/>
        <property type="gene ID" value="AA958_26480"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_26480"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5573"/>
    <dbReference type="OrthoDB" id="1702107at2"/>
    <dbReference type="UniPathway" id="UPA00085"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008444">
        <property type="term" value="F:CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004570">
        <property type="entry name" value="Phosphatidylglycerol_P_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000847">
        <property type="entry name" value="Phos_ph_gly_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00560">
        <property type="entry name" value="pgsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="10" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AKH85186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="200" mass="21689" checksum="3DEB1F4CB8D7989E" modified="2015-07-22" version="1">MSPAPAVGQAGLWNIANVLTMVRLLLVPAFVLLMAAHGGHDPAWRSFAWAAFTVAMITDLFDGELARRYDLVTDFGKIADPIADKAIMGAALICLSALGDLPWWVTIVILAREIGITLMRFWVIRHGVIPASRGGKLKTLAQGVAVGMYILTLTGPLATLRFWIMAAAVVLTVATGLDYVKQAIVLRRRGLAAEREQRVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAX5</accession>
    <name>A0A0F7NAX5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_26995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018517.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_26995"/>
    <dbReference type="EnsemblBacteria" id="AKH85281">
        <property type="protein sequence ID" value="AKH85281"/>
        <property type="gene ID" value="AA958_26995"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_26995"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5680"/>
    <dbReference type="OrthoDB" id="1944256at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016499">
        <property type="entry name" value="NucleicA-bd_Rv2694c_prd"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006910">
        <property type="entry name" value="NA_bind_Rv2694c_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="134" mass="14577" checksum="A12C7D8AA903646D" modified="2015-07-22" version="1">MDPARSADRPAGPFRRLLGRITGAAEPPAEDSLPPDEETADVTPIRQCHDRAVVTVTGSLRTVTLQPRAGVPALQAELFDGTDSLDLVWLGRRAIPGIEPGRSLTASGRIAMSRGRRVLFNPKYELRPLGQEQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NB07</accession>
    <name>A0A0F7NB07_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ArsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_27230</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018546.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_27230"/>
    <dbReference type="EnsemblBacteria" id="AKH85311">
        <property type="protein sequence ID" value="AKH85311"/>
        <property type="gene ID" value="AA958_27230"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_27230"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5737"/>
    <dbReference type="OrthoDB" id="1617768at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH85311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="132" mass="14962" checksum="127A15B9AC9C3BCF" modified="2015-07-22" version="1">MTVAVDDELWSAIGDPIRRRLLDLLLAEGVGTPTSLSDRLPVTRQAVAKHLGVLDRAGLVHATPIGRERRYEVDEAQLARAVRQLNEVGKTWDARLNRIKRIAEQIQRQKHDRETRPRNTTDRQATAPLEDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NB76</accession>
    <name>A0A0F7NB76_9ACTN</name>
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        <submittedName>
            <fullName evidence="3">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_19035</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_19035"/>
    <dbReference type="EnsemblBacteria" id="AKH83942">
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        <property type="gene ID" value="AA958_19035"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_19035"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3996"/>
    <dbReference type="Proteomes" id="UP000034283">
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    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="12"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH83942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="275" mass="29500" checksum="572513BF4C0B8DFA" modified="2015-07-22" version="1">MGLSSETDADIARVTEALAMITPRWNVRILLALAAEPLRYHELAARLPWLKDSQFHPKTRTLCDAGLVERTEHSPRHVTYGLTDRGAALLPVLPVIVTWAEAHLEEAAQPPSTIEQIEDSLTLLTRRHAAGILWALKIRGETSGRALFQLVMPHSAWSNIYPPLRQLAVDGLVDTDGPGRPYRLSAAGEALGPVLGALSAWAAGKPFNHAAHHPVWGHTQPLSAPKPRAGHPTRPTTTPPAVPRPGGARPSYSDLFSHATPAGPPAALPAGGPNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NB99</accession>
    <name>A0A0F7NB99_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_27610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018610.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_27610"/>
    <dbReference type="EnsemblBacteria" id="AKH85376">
        <property type="protein sequence ID" value="AKH85376"/>
        <property type="gene ID" value="AA958_27610"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_27610"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5818"/>
    <dbReference type="OrthoDB" id="1414738at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH85376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="193" mass="19917" checksum="C73E902649169D14" modified="2015-07-22" version="1">MNLVVNGDAETGPGGTPDPVTTVHGWRLTHGAPALVPYDLGGGYPTPGDPGPAHRGTRFFTGGNSPRTALLQDIDLPRTGPTGHKAIDAGRVHYTLTAWLGGYAGQQDGARLSAELRDTRGTPLALTVLGPVTAEERAGRTALLERTATAPVPPGARTARLLLTLTRAGGTANDGYADALSLTLTTTRRGGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBE1</accession>
    <name>A0A0F7NBE1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_24105</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NADH dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_24105"/>
    <dbReference type="EnsemblBacteria" id="AKH84784">
        <property type="protein sequence ID" value="AKH84784"/>
        <property type="gene ID" value="AA958_24105"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_24105"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5080"/>
    <dbReference type="OrthoDB" id="403436at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006116">
        <property type="term" value="P:NADH oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045024">
        <property type="entry name" value="NDH-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706">
        <property type="entry name" value="PTHR43706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="3">
        <location>
            <begin position="4"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="388"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH84784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="413" mass="42641" checksum="DB68F60AD8D1F7A3" modified="2015-07-22" version="1">MKHRIVVLGAGYAGAYTAGNLARRLSPADTGITVVNAVPEFVQRLRLHRLAAGGEIAAPRLADVFAGTGIRLRVARVTALAPESRIVAVADADGGGLLHYDTLVYALGSRVAHRGVPGVAEHAFHVTARPAALRLRDRLDGLDRKGEGGAVLVVGDGLTGIETATEIAEARPGLSVTLVARGELGARLSPGARAHLRRACDRLGIAVREHTRIESVEAAGVRCADGTAVASDATVWTGGFAVDPLAAAAGLEVTGTGQLAVDRTMRSVSHPDVYGVGDSVCAVGDNGRPLPMSCGSAGYTGRQAIGAIVGHLTGREVAYTKLVHTFNHISLGRRDGILQPVDDAAEARPGYVAGRTAARVKAAIVRGSLWGTLHPTYGLPKRRRRLAAAAGTATETAPDPSWDATGEIPSVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBP1</accession>
    <name>A0A0F7NBP1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Isorenieratene synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_24630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018115.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_24630"/>
    <dbReference type="EnsemblBacteria" id="AKH84863">
        <property type="protein sequence ID" value="AKH84863"/>
        <property type="gene ID" value="AA958_24630"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_24630"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5194"/>
    <dbReference type="OrthoDB" id="630753at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amino_oxidase" evidence="1">
        <location>
            <begin position="44"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="522" mass="56643" checksum="A580C6A475C98CB6" modified="2015-07-22" version="1">MPPRRTTAPRRGRDRKAEILFPAPGAERFRRGDEPSVAVIGGGIAGLAAATLLAERGARVTLYEKEDSLGGRLAGWRTTLADGSAVTMTRGFHAFFRQYYNLRGLLRRTDPGLERLTPLPDYPLRHSGGPADSFARVPRTPPLSALGFVALSPTFGWRDLAAMDARAALPLLDVRVPEVYEHFDTVTATGFLESVRFPDAAHHLAFEVFSRSFFADPRELSAAELLLMFHVYFLGSAEGLLFDVPGDPFPQALWDPLGDYLRCLGASVRTGTPVLGVRTRDGGGADVITDTGTDGHQAVVLALDAAGLRQAVAASPGLGTAAWRDDIAALRTAPPFLVSRLWLDRAVRADRPGFLGTSGYGGLDNISILERYEGEAARWAARTGGSVVELHAYAVDPAAEQEQEQDVLVDRLHQVYPETREARVVDARHEWRSDCPLFAVGSHRRRPTVRTPHPWLTLAGDGIRCDLPVALMERAATTGFLAANALLADRGVRGQVLWTVPRSGRSPLLRALGAVAGRHPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NC97</accession>
    <name>A0A0F7NC97_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_32075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019318.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_32075"/>
    <dbReference type="EnsemblBacteria" id="AKH86090">
        <property type="protein sequence ID" value="AKH86090"/>
        <property type="gene ID" value="AA958_32075"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_32075"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6772"/>
    <dbReference type="OrthoDB" id="1467120at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="9"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="270" mass="29267" checksum="B0B1A811E1CECE78" modified="2015-07-22" version="1">MTQETEAAGLTVDELAARAGVTVRTVRFYSTRGLLPPPVIGPRRVGRYGPEHLSRLALIEELQHQGLTLAAIERYVQQLPPGLSAEDHALHRALVATWVPDAETEVSRAELERRAGRSLTDDDVARLAAMGVLERTPPGPGAYDAGSGTHDAAAAAYDTASGADGGDDTFRVDPVVLHLGVRLLDVPIRLETVLAARDVVHEHSRAVARELTRLFHDEVWEPFGEADPDPEQVETMKSLSAHMQPMVVQALVTAFQRSMKAELRASFPPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCB7</accession>
    <name>A0A0F7NCB7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_21450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017600.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_21450"/>
    <dbReference type="EnsemblBacteria" id="AKH84337">
        <property type="protein sequence ID" value="AKH84337"/>
        <property type="gene ID" value="AA958_21450"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_21450"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4516"/>
    <dbReference type="OrthoDB" id="1249244at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041497">
        <property type="entry name" value="Thump-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18096">
        <property type="entry name" value="Thump_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="105"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Thump_like" evidence="2">
        <location>
            <begin position="326"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH84337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="403" mass="41811" checksum="0988F0583AEAA3D7" modified="2015-07-22" version="1">MHGPDAPDDPLAALLTPEGQALLAELREHDPADELALATRLRRTHPAELVSAALGQARLRQRAAAKFGADAARMYFTPDGVEQATRTAVAAHRAARFTALGVDRVADLCCGVGGDAVALARAGIAVLAVDRDPAAAAAARANAAALGVAERVEVRCAEVGDVDISGYDAVFVDPARRVGGRGRVFDPEAYSPPLSWAVEVAGRVSHAALKVAPGIPHEAVPEAAEAEWVSDAGDVKEAVLWFGAASGAVSPGRRRATLLPGGATLVGRGLPDPPAGPVGRYLYEPDGAVIRAHLVAEVAAQAGGRLLDPTIAYVTADDLVRTPYATAYEITDTLPFHVKKLRALLRERGVGSVTVKKRGSAVEPEELRRKLKLTGPAAVSCTVFLTRVAGAPTVLLGRPAPAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCT9</accession>
    <name>A0A0F7NCT9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Riboflavin biosynthesis protein RibD</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="10">Diaminohydroxyphosphoribosylaminopyrimidine deaminase</fullName>
                <shortName evidence="10">DRAP deaminase</shortName>
                <ecNumber evidence="10">3.5.4.26</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="10">Riboflavin-specific deaminase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="10">5-amino-6-(5-phosphoribosylamino)uracil reductase</fullName>
                <ecNumber evidence="10">1.1.1.193</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="10">HTP reductase</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="15" type="ORF">AA958_33340</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + H(+) + H2O = 5-amino-6-(5-phospho-D-ribosylamino)uracil + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:21868"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:58453"/>
            <dbReference type="ChEBI" id="CHEBI:58614"/>
            <dbReference type="EC" id="3.5.4.26"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>5-amino-6-(5-phospho-D-ribitylamino)uracil + NADP(+) = 5-amino-6-(5-phospho-D-ribosylamino)uracil + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:17845"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58421"/>
            <dbReference type="ChEBI" id="CHEBI:58453"/>
            <dbReference type="EC" id="1.1.1.193"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10 13">Binds 1 zinc ion.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Cofactor biosynthesis; riboflavin biosynthesis; 5-amino-6-(D-ribitylamino)uracil from GTP: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Cofactor biosynthesis; riboflavin biosynthesis; 5-amino-6-(D-ribitylamino)uracil from GTP: step 3/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 10">In the C-terminal section; belongs to the HTP reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">In the N-terminal section; belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.26" evidence="10"/>
    <dbReference type="EC" id="1.1.1.193" evidence="10"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019525.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_33340"/>
    <dbReference type="EnsemblBacteria" id="AKH86300">
        <property type="protein sequence ID" value="AKH86300"/>
        <property type="gene ID" value="AA958_33340"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_33340"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.7041"/>
    <dbReference type="OrthoDB" id="1775351at2"/>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008835">
        <property type="term" value="F:diaminohydroxyphosphoribosylaminopyrimidine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004794">
        <property type="entry name" value="Eubact_RibD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011549">
        <property type="entry name" value="RibD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006769">
        <property type="entry name" value="RibD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00326">
        <property type="entry name" value="eubact_ribD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00227">
        <property type="entry name" value="ribD_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 10 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="10 12" id="KW-0521">NADP</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0686">Riboflavin biosynthesis</keyword>
    <keyword evidence="8 10 13" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="14">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="47"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
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        <location>
            <begin position="304"/>
            <end position="310"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR006769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR006769-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR006769-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR006769-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AKH86300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="380" mass="37549" checksum="F7AAF96533B6A680" modified="2015-07-22" version="1">MRRAIALASRALGDTSPNPVVGCVILDAAGHPAGEGHHARAGGPHAEVAALADAGERARGGTAVVTLEPCSHTGRTGPCVRALADAGVVRVVYAVADPTPAAGGGAAALAAAGIEVEGGLLADEAAAGNEPWLTSVLRGRPYVLWKYAATLDGRSAAADGTSRWITSPAARADVHRLRAEADAVVVGSGTLRADDPQLAVRGPRAEAGVTQPLRVVADTGGTALTPGARILDGAAPTLVAVAADAADSAVGRLDAVLDAAAVRAGRRADVVRLPRAAGGRGLDVAALLAALYGRDVRSVLLEGGPALAGAFLAAGVVDRVVCYLAPVLLGAGPAALADAGIGTIGEALRLDVTAVDHLGPDLRLTAVPGPAPEPPATKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7ND05</accession>
    <name>A0A0F7ND05_9ACTN</name>
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        <submittedName>
            <fullName evidence="3">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_33535</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
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        </lineage>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="12"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="141"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH86335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="422" mass="44950" checksum="CB0F6182F638A7D3" modified="2015-07-22" version="1">MSTHPPITARPVRVAVAGAGNRGRTYADWVRAHPERAELVAVADPDPAARAAVAAPREFGDWRALAAAGVEADAVVVATQDRDHVDPVLAFAEAGYAVLAEKPLAPTEEETRRIVEGVERTGVLFAVCHVMRYMPYTDLVKEVVDSGVLGELVSLDHLEPVGWWHYAHSYVRGPWRKEELSSPMLLAKSCHDLDWIAYVTGARIERVTGFGGLKHFRPENAPAGAGERCTDCAVEADCPYSAQKLYLPVLREKGAVWPVTHVTGATGRTDEAGLLRALRTGPYGVCAYRADNDVVDHQVLAMLLSGGVTATFQMVAFTEQTHRQTRVFGSHGWLRGDGESVTVQDFRTGETTVRTVGAAGSSAADGHGGGDAGLMDAFVRAVATGDSGVLRSGTAASLGSHLAAFAAERARHTGTVQAVPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7ND60</accession>
    <name>A0A0F7ND60_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_27600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
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        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_27600"/>
    <dbReference type="EnsemblBacteria" id="AKH85374">
        <property type="protein sequence ID" value="AKH85374"/>
        <property type="gene ID" value="AA958_27600"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_27600"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5816"/>
    <dbReference type="OrthoDB" id="626511at2"/>
    <dbReference type="Proteomes" id="UP000034283">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519960" evidence="1">
        <location>
            <begin position="33"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="421" mass="44680" checksum="0748283CFA1A15E7" modified="2015-07-22" version="1">MQRTPTRSRWRRVALTGVICAAAVAHPAYAGAAGGSAGAGGPAPPATWRADLADVGADDVNVRYVQGDLRLRSRTAAPASLGSVPGEGSQVLAPERLDRPVNRVRAELDARVPAGAGVAVDVRGRAQDGGWTEWLPAGAEAAEAARLPFAVTDVQARLTLRASGTGAAPAVQGLRLRADTDAAPRARAAAAPLTYRLFATREGLVGGTTANGHVIQPNDHFVALPSRRGLSPKGSAEYSVQVCGPARCETAPVWDVGPWNTKDDYWSPPSVRESWRDLPQGMPEAQAAYQNGYNGGRDEFGRRVANPAGIDLADGTFYNVGLNDNGWVDVTFLWTGDQTGKRFPTWGTDVRVRQASNTSSAVLTTLPGPTQVRVECQERGEQITYDGHTNDAWAYLPDYGGYISNIFIDVADAWLPGVPEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7ND66</accession>
    <name>A0A0F7ND66_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cellulase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_33930</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019627.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_33930"/>
    <dbReference type="EnsemblBacteria" id="AKH86405">
        <property type="protein sequence ID" value="AKH86405"/>
        <property type="gene ID" value="AA958_33930"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_33930"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.7164"/>
    <dbReference type="OrthoDB" id="1395441at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018087">
        <property type="entry name" value="Glyco_hydro_5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00659">
        <property type="entry name" value="GLYCOSYL_HYDROL_F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519961" description="Cellulase domain-containing protein" evidence="3">
        <location>
            <begin position="31"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="Cellulase" evidence="4">
        <location>
            <begin position="60"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH86405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="363" mass="39974" checksum="E22B8A1D22A30D34" modified="2015-07-22" version="1">MHRKARKLLLAFLAAVAVLVTVIAPGQATAGPAPEGAAPADAAPEAAVPWLKTEGNRIKDAAGNPVTLRGVSMIGPRHNNECSSCNPKPMAELINRATDPALGWHSKVIRLPVTEWAPNDSLSLEENFRQHIDPYVQQAVARGVYIIVDLHKVQDYGGTSGMPQQRVQDFWSYVAPKYKDIPNVIFEVYNEPINPDSWATWKSYIQPVVNRVRAAAPKNLILMGGPQWSTRVNQAAADPVSGGNIAYVYHLYPNQGAATAANLDAKFGNAAKKIPVILTEFGWNPEGPWSDPVTKGTTSGWGTPLRQYLDARPEISWVAWAYSNYWKPMMYDHDWNLLGGEHQGQFIKKWLAEKKTANQPAHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDG4</accession>
    <name>A0A0F7NDG4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_27815</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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        <property type="project" value="UniProtKB-KW"/>
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    </evidence>
    <evidence type="ECO:0000313" key="9">
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</entry>
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    <accession>A0A0F7NDU8</accession>
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        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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                <person name="Albersmeier A."/>
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                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7 8">CNQ-509</strain>
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</entry>
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                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
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            <dbReference type="EMBL" id="AKH86431.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="423" mass="46638" checksum="3D0EA367D3AEF02B" modified="2015-07-22" version="1">MRKLRGWVAALAATVMAGGTLSATPAVSSQSEAAAQTVPPVINGPVFHDPTAPAGSSARRAVIDQLIRLFQSTTPDSEVHLAMHQWMVTENTSGEDVLSALTQARIRGAEIKVIIDSALAEHEETYDRLGIALGNDVTADSWAMRCPDNRGCITGGPNVDGAGYLHNKFALFTNLSVDGTTYRNTVFQSSSNLHDWYINVSFNDAYTLATQSAGTPEDQIYNRYRDYFLDLQERAAGSPTDHYYQSYAAGKYRVGFYPHRKQTSATDDPVRQVLDRINGCEHPGPDGNRYVTRIDFALTHWTNYRTNIAEKVAELARRGCVITVIIGGELGTEVEAELRSVPTIDLIVCRRDGEKPQTKITMFKGPYNGTPTSRVITGSANFTQMPRSDDIELELVGDDTYARYWEWFGQLYSACTQLPSASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NE41</accession>
    <name>A0A0F7NE41_9ACTN</name>
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        <submittedName>
            <fullName evidence="2">Beta-lactamase</fullName>
        </submittedName>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Winkler A."/>
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                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="28"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="243" mass="26349" checksum="17954B56D14FCF85" modified="2015-07-22" version="1">MAGAVPGLVRITDRVWWWPHHPDPDRVQAGVGVIAGDDGCLLVDAGHSPALARRIRNALGGAGLPKARALVYTHHHWDHVWGAQEWAVPVTAHELTAEALRAEAEKPWSEAYVRAGMARDPRLVPSYTARLRAMAEDGWDSLRIVPPAETFTGRHEIRLGGVTAELRHVGGGHAADSTVVGVPSEGVLFVGDCYYPPPYHLRAEGAGPDLALARELVGGEYQWYVESHEAPRRRKEAEAALGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NEB4</accession>
    <name>A0A0F7NEB4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_07830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019846.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86596">
        <property type="protein sequence ID" value="AKH86596"/>
        <property type="gene ID" value="AA958_07830"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_07830"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1647"/>
    <dbReference type="OrthoDB" id="2063189at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="SSF48403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="56"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="229" mass="25351" checksum="7011B91C30D20FD8" modified="2015-07-22" version="1">MLGLLIALVTCLVLAVSRFRRRRRGTAFLGAVLRGDPAEVRALVDRGYGLGISDARGDTALHYAYYAGDHELVQTLLALGAREESYNRDGLLPHQLAEVAEAELRIEELVDLLRRYDGEATARAAELAEELRPYHRAPVYPAALTNVLARTGDGEPLRAVLRTAIRLGRPDFLAVLEEELGRRGDREIAEDYLNSGSPRLGYAAQRWAQEHRFAITDHGQGARAGWGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NEI6</accession>
    <name>A0A0F7NEI6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_11660</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019967.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86696">
        <property type="protein sequence ID" value="AKH86696"/>
        <property type="gene ID" value="AA958_11660"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_11660"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2452"/>
    <dbReference type="OrthoDB" id="1941671at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036689">
        <property type="entry name" value="ESAT-6-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140453">
        <property type="entry name" value="SSF140453"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH86696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="102" mass="11193" checksum="86FB23E1CED39966" modified="2015-07-22" version="1">MADRLAVDGDELERFMRLLKRSVRSLEGVHRALRDSTISGLGTDDLDDACQDFQDDWKYGTGQIGEQVEELAEIVGDSKESYAEVDKALEENLAKSAQGGGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NEW6</accession>
    <name>A0A0F7NEW6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_31500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019222.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_31500"/>
    <dbReference type="EnsemblBacteria" id="AKH85994">
        <property type="protein sequence ID" value="AKH85994"/>
        <property type="gene ID" value="AA958_31500"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_31500"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6654"/>
    <dbReference type="OrthoDB" id="1694303at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016857">
        <property type="term" value="F:racemase and epimerase activity, acting on carbohydrates and derivatives"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008000">
        <property type="entry name" value="Rham/fucose_mutarotase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05336">
        <property type="entry name" value="rhaM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH85994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="103" mass="11600" checksum="BCC46650B819117D" modified="2015-07-22" version="1">MRIALRTQVRADRIEEYEAAHREVPGELTAAIRGAGATSWTIWRSGTDLFHVIECEDYARLLAELEHLPVNVAWQARMAELLDVVHDYTDEGTGAGLPVVWEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NEY0</accession>
    <name>A0A0F7NEY0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_27000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018518.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_27000"/>
    <dbReference type="EnsemblBacteria" id="AKH85282">
        <property type="protein sequence ID" value="AKH85282"/>
        <property type="gene ID" value="AA958_27000"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_27000"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5681"/>
    <dbReference type="OrthoDB" id="1899949at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016566">
        <property type="entry name" value="UCP010219"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11361">
        <property type="entry name" value="DUF3159"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="114"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="143"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="218"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH85282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="275" mass="28786" checksum="7860FF0FE201F440" modified="2015-07-22" version="1">MTYFQKPADERAGGTGATGGPPGTAPAPAPPSGDGAGRTASDVPEGDSQAVTQAAMAEAFGGIRGMVETTVPGLVFVLVYTIGSDIKPSAIAALGVSLLLGLTRLITGGTFKHAFSGVFGVVIGVAFANMTGNAKDFYLPGLLYGLGLALAYILSTLAGLPLIGVILGPLFRENLSWRTRNPGRKKAYAKASWAWGLIFLAKSAILFPLYFWADPKEFGWVIVALKIPPLLLAVTLTYIFLKQAPPPIDVIAEAEAEEKAQAEREKAGRPAAERD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NEY9</accession>
    <name>A0A0F7NEY9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_24505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020384.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_24505"/>
    <dbReference type="EnsemblBacteria" id="AKH87015">
        <property type="protein sequence ID" value="AKH87015"/>
        <property type="gene ID" value="AA958_24505"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_24505"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5163"/>
    <dbReference type="OrthoDB" id="537440at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase" evidence="1">
        <location>
            <begin position="48"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH87015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="367" mass="39541" checksum="254140C0CCB26A78" modified="2015-07-22" version="1">MLVAAATVLAVVAGSAAAPPRDGDEPPGAAELRKRLDGLVAEGAVGGLVEVRDGRRVWRVTGGVAERDTTRAVPARGRFRIGSITKTFVATVVLQLAGEGRLRLDDPVEDWLPGAVPDGRRITVRHLLGHTSGLYDYKRTLTVPPDPAFLDYRSRTWTPEEQIRRAVAHPPTSTPPGTAYAYSNTGYLLLGRIIEEATGRPYAEEIGRRILRPLRLHATSLPGTYPRIRGAHMRGYVPVGRAGGIQLADFTEMNPSLFGASGEMISTAGDLDRFLAALLGGRLLPDHLLAEMRTPSSGDRTYGLGLAWQETSCGVTVYGNDGDALAYQSWSFTTPDLRRHVTVALTPEHRADLDDSVDALLDAAFCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NF75</accession>
    <name>A0A0F7NF75_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_31495</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019221.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_31495"/>
    <dbReference type="EnsemblBacteria" id="AKH85993">
        <property type="protein sequence ID" value="AKH85993"/>
        <property type="gene ID" value="AA958_31495"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_31495"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6653"/>
    <dbReference type="OrthoDB" id="1356861at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH85993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="253" mass="25783" checksum="2CFEB0EB8E2D7421" modified="2015-07-22" version="1">MKDFDGLKAVVTGGASGIGLATARLFAERGAQVAVLDLHPDGVPQPLRGYRADVSDDASVAAAIGDAAGALRGIDVLVNNAGIGAVGTVEDNDDAEWHRVLDVNLLGVVRTTRAALRHLRRSAHPAIVNTCSVAATAGLPQRALYSATKGAVQSLTLAMAADHVREGIRVNCVNPGTADTPWVSRLLDQAPDPAAERAALHARQPMGRLVTAGEVAAAIAYLASPAAASVTGTALAVDGGMQGLRLRAPESGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFB9</accession>
    <name>A0A0F7NFB9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Salicylyl-CoA 5-hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_27705</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018626.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_27705"/>
    <dbReference type="EnsemblBacteria" id="AKH85392">
        <property type="protein sequence ID" value="AKH85392"/>
        <property type="gene ID" value="AA958_27705"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_27705"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5838"/>
    <dbReference type="OrthoDB" id="1033671at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003959">
        <property type="term" value="F:NADPH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02932">
        <property type="entry name" value="OYE_YqiM_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044152">
        <property type="entry name" value="YqjM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43303">
        <property type="entry name" value="PTHR43303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="3">
        <location>
            <begin position="3"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="Oxidored_FMN" evidence="2">
        <location>
            <begin position="395"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="737"/>
            <end position="769"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH85392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="769" mass="82557" checksum="62C420F7638D0950" modified="2015-07-22" version="1">MRAAVIGGGPGGLYAAALLKRLDPARTVTVYERNAPDSTYGFGVVLSDETLGGIEHADPAVYAALQREFVRWDDIDIVHRGTVQRSGGHGFAALGRRRLLAVLQQRCRDLGVDLRFRTEAPPAAELARGHDLVVGADGVNSATREAHADVFRPRIAEHRCRYVWLSAPFAFGAFRFEIVETDAGVMQLHGYPYAISAASSGGASTVIVEMREEVWRRAGFDACGEEETAKRCAAYFADALGGRPLTGNRSQWTAFRTVVNDRWWHHPSPGGGAVVLLGDAAHTAHFSVGSGTKLAVEDALALAACVGEQPDVPAALAAYEAERKPVVASTQRAAHASREWFEDLARHLGRPPRQFAFDLLTRSRRITHDNLRLRDPGFVAAVEREAGVPEGTPPMFTPYTLGGLTLRNRVVCSPMDMYVAEDGLPGDFHLVHLGARALGGAGLVMTEMVCVSPRGRITPGCTGLWSDEQEAGWRRVVDFVRGHAPGAALGIQLGHSGRKGSTKLMWEGIDEPLPEGNWPVVAPSPLPYRAGLNQTPRALDRAGMDAIREEFAAAARRAARAGFDLLELHCAHGYLLSGFLSPLTNRRTDAYGGDLDARLRYPLEVFDAVRAAWPADRPVTVRISATDWAEGGTTAADAVAVARAFAAHGAAAIDVSTGQVVADEQPAFGRSYQTPYADRIRAETGIPVIAVGAISSWDDVNSLILAGRADLCALGRPHLYDPHWTLHAAAEQGYTGPGAPWPAPYRAGSRRPPTGRADGPKPRLTLDGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFD7</accession>
    <name>A0A0F7NFD7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_32615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019406.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_32615"/>
    <dbReference type="EnsemblBacteria" id="AKH86179">
        <property type="protein sequence ID" value="AKH86179"/>
        <property type="gene ID" value="AA958_32615"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_32615"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6889"/>
    <dbReference type="OrthoDB" id="1984437at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="2"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="137" mass="14897" checksum="F933003BF5C04051" modified="2015-07-22" version="1">MKTLFVSYRVTDLDRSLRFYTALGYVELGSVEIGDGAHLVILKLPDEPAASLELVHRPVDGRVDVGSGFDHLAIQVDTLAATLERLTDAGLEPEPVQYPGGPRGPKTSWLTDPDGYRIELVEWPPGHPDGITAADFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFD9</accession>
    <name>A0A0F7NFD9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acetyl-CoA acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_27835</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018646.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_27835"/>
    <dbReference type="EnsemblBacteria" id="AKH85412">
        <property type="protein sequence ID" value="AKH85412"/>
        <property type="gene ID" value="AA958_27835"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_27835"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5867"/>
    <dbReference type="OrthoDB" id="550338at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="4">
        <location>
            <begin position="8"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="5">
        <location>
            <begin position="275"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="2">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="354"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH85412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="406" mass="42744" checksum="7521FEA7D7AC4B94" modified="2015-07-22" version="1">MPRTARDVVFVDGVRTPFGKAGPKGIYHETRADDLVVKCIRELLRRNPALDPATVDDVAIAATTQIGDQGLTIGRTAGILAGLPPTVPGYSIDRMCAGAMTAVTTTAASTAFGAYDIALAGGVEHMGRHPMGEAVDPHPRFVSEKLVDESALFMGMTAENLHDRFPHLTKSRADAYAVHSQEKAAKAYANGRIQADLVPISVRRTTTEAGETGWGLATQDEPMRPGTTLANLATLKTPFRAHGRVTAGNAAGLNDGATASLIAAEDVARAAGLPVKMRLVSFAFAGVEPEVMGVGPIPSTEKALAKAGLGIGDIGLFEINEAFAVQVLAFLDHFGIADDDPRVNQYGGAIAFGHPLASSGVRLMTQLARQFEEQPQVRYGITTMCVGFGMGATVIWENPHFEGAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFN2</accession>
    <name>A0A0F7NFN2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_29110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_29110"/>
    <dbReference type="EnsemblBacteria" id="AKH87101">
        <property type="protein sequence ID" value="AKH87101"/>
        <property type="gene ID" value="AA958_29110"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_29110"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6135"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003718">
        <property type="entry name" value="OsmC/Ohr_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036102">
        <property type="entry name" value="OsmC/Ohrsf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02566">
        <property type="entry name" value="OsmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82784">
        <property type="entry name" value="SSF82784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH87101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="145" mass="15616" checksum="3519D10CCD71ED28" modified="2015-07-22" version="1">MPHTAAFANPGSKQEGTVDIAYVPGELHRISAGGHRRLTDRQSSAGGGGPAPTTAELFVTSPAACMAYYAGRYLHRHGKTRDGLRVQSTFAMAADRPARVARVTVRLAVPADLTERQREVLLSVVRHCTVHNSLLHPPEIEVELG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFU2</accession>
    <name>A0A0F7NFU2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aromatic ring-opening dioxygenase LigA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_32675</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019415.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_32675"/>
    <dbReference type="EnsemblBacteria" id="AKH86188">
        <property type="protein sequence ID" value="AKH86188"/>
        <property type="gene ID" value="AA958_32675"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_32675"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6902"/>
    <dbReference type="OrthoDB" id="1328828at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH86188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="393" mass="43656" checksum="66DADF8C7F5014DB" modified="2015-07-22" version="1">MNADRLLRETLHDWAEEIPPPPGPDLADRALLRRRRRRATAVTVTAAAFALLVGGVAVPVLAETDRPGRPEPERMINDDVSAHPRESPPRRLVAAGNVAVSAYQADRSTEERDGVERTTYTWHLYDPGTQQYEKTRWGWLDVAPGMRQAAVLEKTLPASRVGILELDTGKVTKWIPLEHEAGGVQWSPDGKRLVVTAYRGYPDVETDDLDRYTSSHARTGYYLVDVDSGRKEYRPTGVDTDGRSVGVGRMDVRWSRDGTSLRVLGAPGGDTIVTWYDLEGRARKKAPPYEGLDQVHAGLSPDGRHYTVGDGWRATVKETRTGRTVPGSSGSMTLAWADNGRLVRWECSPDRNCVQGMGERLVLTDPAGRDKIPLTGARYENTPRDWEPLITQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NG24</accession>
    <name>A0A0F7NG24_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Methylmalonyl-CoA mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_33755</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterodimer of an alpha and a beta chain.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019596.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_33755"/>
    <dbReference type="EnsemblBacteria" id="AKH86374">
        <property type="protein sequence ID" value="AKH86374"/>
        <property type="gene ID" value="AA958_33755"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_33755"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.7127"/>
    <dbReference type="OrthoDB" id="720283at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016866">
        <property type="term" value="F:intramolecular transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.196.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016176">
        <property type="entry name" value="Cbl-dep_enz_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024067">
        <property type="entry name" value="Me-malonyl-CoA_mutase_sm_su_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006099">
        <property type="entry name" value="MeMalonylCoA_mutase_a/b_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01642">
        <property type="entry name" value="MM_CoA_mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51703">
        <property type="entry name" value="SSF51703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00544">
        <property type="entry name" value="METMALONYL_COA_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="METMALONYL_COA_MUTASE" evidence="3">
        <location>
            <begin position="357"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH86374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="604" mass="62711" checksum="2D5EC346EAB4571E" modified="2015-07-22" version="1">MTVLPDDGLSLAAEFADASHEEWQHLVAGVLRKSGKEVSGAEAESLLSTAVEDGLRTPPLYTARDRAPDPGLPGFAPFVRGGRPEGNAAGGWDVRQRHAVPDAEAVLGDLENGATSLWLAAGDAGGIPVAALADVLKDVYLDLAPVVLDAGAETEAAARELLRLYEERGIDAGAARGGLGADPLGHEARTGQPGDPGAMAALARLCADRHPGLRAVTVDALPYHEAGGSAAQELGCSLATAVAYLRELTAAGLSTAQACAQLEFRYAATADQFLTVAKLRAARRLFARVAEVCGAPAAGAQLQHAVTSPVMATRRDPWVNMLRTTVATLAAGVGGADAVTVLPFDHAIGLPDTFSRRIARNTSAILVEESHLARVIDPAGGSWYVEGLTDELAHAGWAFFQEIERAGGHAAALRSGMVGERLARTWAERGRRLATRREPVTGVSEFPDLAEKPVVREPAPEPPSGGLPRVRRDEAFEALRARSDAHLAATGARPRVFLAALGPAAVHTPRLTFAANLFQAGGVEPVTGGTFAESGAREACLCSGDTVYAEQGAAAAAELRAAGARHVYLAGRPDACDGADTYVHAGCDALAVLTDALDRMGVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NH31</accession>
    <name>A0A0F7NH31_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">LytR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_31800</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019270.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_31800"/>
    <dbReference type="EnsemblBacteria" id="AKH86042">
        <property type="protein sequence ID" value="AKH86042"/>
        <property type="gene ID" value="AA958_31800"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_31800"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6716"/>
    <dbReference type="OrthoDB" id="1958442at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007492">
        <property type="entry name" value="LytTR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04397">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00850">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50930">
        <property type="entry name" value="HTH_LYTTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="3"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="HTH LytTR-type" evidence="3">
        <location>
            <begin position="152"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH86042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="261" mass="28318" checksum="5ACEF9DD24F20754" modified="2015-07-22" version="1">MLHTLAVDDEEPALAELAYLLRRDPRVAEVQTAGDGQQALLALDRALASGRSVDAVFLDIGMPGLDGLALARLISRFAQPPRVVFVTAHEDHAVEAFALHAADYVLKPVAPERLAEAVRRCAESAAEPVPEEQAEPAGAAPAERAAAPDEVISVELAGVTRFVQRSEVLYAEAQGDYARLHTGGGSHLVRIPLATLEERWGAAGFVRIHRSHLVALHHVRELRMEAGRTYVVLGGHMLPVSRRHTRQVREMLVRHPPTAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NH43</accession>
    <name>A0A0F7NH43_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Septum formation initiator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_14365</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_14365"/>
    <dbReference type="EnsemblBacteria" id="AKH86759">
        <property type="protein sequence ID" value="AKH86759"/>
        <property type="gene ID" value="AA958_14365"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_14365"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3023"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022521">
        <property type="entry name" value="CHP03815_CpaE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002586">
        <property type="entry name" value="CobQ/CobB/MinD/ParA_Nub-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01656">
        <property type="entry name" value="CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03815">
        <property type="entry name" value="CpaE_hom_Actino"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CbiA" evidence="2">
        <location>
            <begin position="115"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH86759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="353" mass="35941" checksum="C70E2157335D6EDB" modified="2015-07-22" version="1">MVVTEDEDLLDDLLRLCAAAGTQAEVSHAPGRQDWGAAPLVLVGDDCAGRLAAGRARRDGVVLVGRDQDDPGVWERAVAVGAEQVVVLPDGETTLVDRIADAAEGVGAQARTVGVVGGRGGAGASTLACALAVTAARAGRRTVLVDADPLGGGLDVLLGGEEAEGLRWPALASSRGRIGGAALEESLPRLHGLRLLSWDRGGGEPGAVAPEAMRSVLAAARRRGGVVVVDLPRRVDEPVAEALAQVDVGLLVVPAELRAVAAAHRVADAVRMVLGDLRVVVRGPTRGGLPAEDVAELLRLPLAGELPAEPGLPQAAETGAAPPGSRPRTPLSRFCTDFWARALPGASAEGAPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NHP0</accession>
    <name>A0A0F7NHP0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_33125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019488.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_33125"/>
    <dbReference type="EnsemblBacteria" id="AKH86262">
        <property type="protein sequence ID" value="AKH86262"/>
        <property type="gene ID" value="AA958_33125"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_33125"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6998"/>
    <dbReference type="OrthoDB" id="1853207at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="233" mass="22911" checksum="DEEA9088D741E3D3" modified="2015-07-22" version="1">MTAAEHGGAGSGGAAPGRGAVEDHLAALDAALHGPARVKSRMLAEVRDGLTDAADAHAEAGAPSQAAAAARAVRDFGTVAEVGPAFQRELTVAQARQTARIVALVVPFLMACWYLVGATAADAGGRLPAAVHVLAANLGGLAALAALLAAGSLAATGAVARRAATPRRLPLVVAWTGTTAAVALAVSALTLTAGAVLARDWPAGALAGAITLVAHTRLAASARACRHCALLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NHZ5</accession>
    <name>A0A0F7NHZ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Penicillin amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_33575</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="5">Binds 1 Ca(2+) ion per dimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S45 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019564.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_33575"/>
    <dbReference type="EnsemblBacteria" id="AKH86342">
        <property type="protein sequence ID" value="AKH86342"/>
        <property type="gene ID" value="AA958_33575"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_33575"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.7090"/>
    <dbReference type="OrthoDB" id="186419at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.439.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014395">
        <property type="entry name" value="Pen/GL7ACA/AHL_acylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043147">
        <property type="entry name" value="Penicillin_amidase_A-knob"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023343">
        <property type="entry name" value="Penicillin_amidase_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043146">
        <property type="entry name" value="Penicillin_amidase_N_B-knob"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002692">
        <property type="entry name" value="S45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34218">
        <property type="entry name" value="PTHR34218"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01804">
        <property type="entry name" value="Penicil_amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001227">
        <property type="entry name" value="Pen_acylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0865">Zymogen</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="602"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001227-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001227-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH86342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="707" mass="74675" checksum="42AD87DE05A4DC37" modified="2015-07-22" version="1">MGIEVYRDSWGIPHIRAAGHRELAYAQGHNAAFDRGWQLEVERHRAAGTSAAFLGEAARDWDVFARRVRLDDTARRCFRRLAEEDRETAGWVSSYVDGVNAGLAEGAARAPEFAATGLAPGRWSPWTPLAVWLSTHILFAGFPAKLWRLMVAGHLGAGAVDLFATDGPGTAGSNGWLVSGERTADGGALIAGDPHRFIENPGVYQQIHLACPEYDVVGFAVPGVPGLPHFGHAGGVAWAITNAMADYQDLYRERLRRRAGRVEALGPDGWQPAAAHTETVEVAGAAATGVEVVETGRGPVIAEVPGSAADGEWEALSLRYPPRVYGELGFTALPALLRAREVGDVDAALDRWVEPVNVVLAADTAGGLLHRVAGTVPVRDEANLRGVVPAWEAAYAWRGRHGPMPSVPVAGGIAVMANDRGPAAPFGAEFAPPYRAERIRELLAGGGSWRAGDMAAVHTDTLNAAARPLLDLLAGLEGLGPAAAELRDRLLRWDLRMAADSADALAYARLRSAVVRALAAHPALAPLADPPPYPALLQPWLDLCTRIGYALGSLLTTDLLPEIDRPALVRAAAEEAAAQLAAAAPGAPATWGEAHRLAPWQALPGGTGASGDPGGPGEPWPGLAGDHDCVLATAAVPGVTDLCARGPAARYVWDVARREESRWVVPFGACGVPGAPHHVDQFAPWRSGELIPVLTDWQALKESHGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NJF1</accession>
    <name>A0A0F7NJF1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AfsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_19580</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AfsR/DnrI/RedD regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020257.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_19580"/>
    <dbReference type="EnsemblBacteria" id="AKH86912">
        <property type="protein sequence ID" value="AKH86912"/>
        <property type="gene ID" value="AA958_19580"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_19580"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4126"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15831">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03704">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="588"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="622"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="665"/>
            <end position="689"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH86912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="689" mass="71079" checksum="76C20618CC9F0051" modified="2015-07-22" version="1">MRFQLLGPLSITDGGETVVLHPSKPANLLAALLLNAGSIVSVDYLQRMVWGDEQPATARAALQTCVLRLRRLFTRHEVVDTPIEAVPGGYRITAGGRSLDLVEFRERVRRTQKPGLSAEAAMGALQGALALWQTGVLANVRSEAIHRDEVPRLLEERLRVVERLCDLRLELGLCGQALVDLWSVTRAHPDHGRFREQLIEALYRTGRQTEALAEYRSFKAYLADGLGVGPSAALQRLELSILRGEDLGPASEPPALAGLPAGTPAAPAPVAEPPGLPPVPWFTGRAEAVATLRRRLTAAPEGAGTPVAELVCGGPGIGKTALAQQVAHLVRDDFPGGRTLVPMAAPDGSPRAAAEVVGELAARLGTPDAGSGPRALLILDDVVDAAQTRDVLTAVPGHGVLLTSRLGLAGLVATHGVRVHRLGPLDGAEARELLTAVLGAERVADEPSGAEELAAVCGHHPLALVIAAARLGTRPALRLGDCARWLADDPLGRLSLSGHPRMSVVELFDAALARLDPDLAAAYVALGALGGPGWHAADGAAVLGLPVAECEAVLERLADAGLVEDGPPGPYHPHPLLRLHARLVAGQAGEGEARGPAGTPGGAGAPGQAGTAGRPAPPGRTGQSSHPAQSGPSGQSGPQTGQGGRPGHVPPPGPAGRAGQPGPAGFANSPSQPSRSTQSNRTSQPRQKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-01-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A097H0X4</accession>
    <name>A0A097H0X4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phenazine biosynthesis protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Putative enzyme of phenazine biosynthesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cnq731</name>
        <name evidence="4" type="ORF">AA958_30760</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="ChemBioChem" volume="15" first="2385" last="2392">
            <title>A Membrane-Bound Prenyltransferase Catalyzes the O-Prenylation of 1,6-Dihydroxyphenazine in the Marine Bacterium Streptomyces sp. CNQ-509.</title>
            <authorList>
                <person name="Zeyhle P."/>
                <person name="Bauer J.S."/>
                <person name="Steimle M."/>
                <person name="Leipoldt F."/>
                <person name="Rosch M."/>
                <person name="Kalinowski J."/>
                <person name="Gross H."/>
                <person name="Heide L."/>
            </authorList>
            <dbReference type="PubMed" id="25224759"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CNQ-509</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PhzA/PhzB family.</text>
    </comment>
    <dbReference type="EMBL" id="KJ451627">
        <property type="protein sequence ID" value="AIT42121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019096.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_30760"/>
    <dbReference type="EnsemblBacteria" id="AKH85868">
        <property type="protein sequence ID" value="AKH85868"/>
        <property type="gene ID" value="AA958_30760"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_30760"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6502"/>
    <dbReference type="OrthoDB" id="1644255at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004964">
        <property type="entry name" value="PhzA_PhzB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03284">
        <property type="entry name" value="PHZA_PHZB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIT42121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH85868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="153" mass="17909" checksum="65071C2BF7CAAFAB" modified="2015-01-07" version="1">MSTDKEVRDHNRAIVEKYMHCRGQDRLERHLLFTEDGTGGLWTTETGEPIVISGRDTLGEHAVWSLKCFPDWAWINIEIFDTQDPNRFWVECDGEGKILFPGYEPGHYRNHFLHSFLFEDGKIKQQREFMNPCQQFRALGIEVPSVRREGIPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MX89</accession>
    <name>A0A0F7MX89_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_00145</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH80840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014207.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH80840">
        <property type="protein sequence ID" value="AKH80840"/>
        <property type="gene ID" value="AA958_00145"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_00145"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.33"/>
    <dbReference type="OrthoDB" id="1180333at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027805">
        <property type="entry name" value="Transposase_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13613">
        <property type="entry name" value="HTH_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_Tnp_4" evidence="2">
        <location>
            <begin position="45"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="DDE_Tnp_1" evidence="1">
        <location>
            <begin position="101"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH80840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="256" mass="28571" checksum="6D92DF98C57BEF6C" modified="2015-07-22" version="1">MAGVITASEPSWIAPFTGVSPRQFSKLITALRREGADPIRKGRPWSLPLEDRVLLVAAYWRTNLTLRQLAPLFGVSKSAADRIVDHLGPSLALQQRKRFRKDTVLIVDGTLVPTRDHAIAEQSKNYRYSTNHQVVIDADTRLVVTIGRPLPGNRNDCKAWELSGAKDAVGRTTVIADGGYRGTGLVIPHRRERGQAELPAWKEEHNTSHRNVRARVEHVFARMKSWKILRDCRLKGDGVHHAMLGIARLHNLALAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MYV2</accession>
    <name>A0A0F7MYV2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Arginine biosynthesis bifunctional protein ArgJ</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="7">Glutamate N-acetyltransferase</fullName>
                <ecNumber evidence="7">2.3.1.35</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="7">Ornithine acetyltransferase</fullName>
                <shortName evidence="7">OATase</shortName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="7">Ornithine transacetylase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="7">Amino-acid acetyltransferase</fullName>
                <ecNumber evidence="7">2.3.1.1</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="7">N-acetylglutamate synthase</fullName>
                <shortName evidence="7">AGSase</shortName>
            </alternativeName>
        </domain>
        <component>
            <recommendedName>
                <fullName evidence="7">Arginine biosynthesis bifunctional protein ArgJ alpha chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="7">Arginine biosynthesis bifunctional protein ArgJ beta chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="7" type="primary">argJ</name>
        <name evidence="8" type="ORF">AA958_03640</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>L-glutamate + N(2)-acetyl-L-ornithine = L-ornithine + N-acetyl-L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:15349"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57805"/>
            <dbReference type="EC" id="2.3.1.35"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>acetyl-CoA + L-glutamate = CoA + H(+) + N-acetyl-L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24292"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-arginine biosynthesis; L-ornithine and N-acetyl-L-glutamate from L-glutamate and N(2)-acetyl-L-ornithine (cyclic): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 7">Heterotetramer of two alpha and two beta chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="7">Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the ArgJ family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.35" evidence="7"/>
    <dbReference type="EC" id="2.3.1.1" evidence="7"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014788.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_03640"/>
    <dbReference type="EnsemblBacteria" id="AKH81430">
        <property type="protein sequence ID" value="AKH81430"/>
        <property type="gene ID" value="AA958_03640"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_03640"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.766"/>
    <dbReference type="OrthoDB" id="1083409at2"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00106"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004042">
        <property type="term" value="F:acetyl-CoA:L-glutamate N-acetyltransferase activity"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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    </dbReference>
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        <property type="term" value="F:methione N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="ArgJ-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="ArgJ_beta_C"/>
    </dbReference>
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        <property type="entry name" value="PTHR23100"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF56266"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ArgJ"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="5 7" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_5023557641" description="Arginine biosynthesis bifunctional protein ArgJ alpha chain" evidence="7">
        <location>
            <begin position="1"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023557642" description="Arginine biosynthesis bifunctional protein ArgJ beta chain" evidence="7">
        <location>
            <begin position="184"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="146"/>
        </location>
        <ligand>
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        </ligand>
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        <ligand>
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        </ligand>
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        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
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        <location>
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        <ligand>
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        <location>
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        <ligand>
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        <location>
            <position position="109"/>
        </location>
    </feature>
    <feature type="site" description="Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole" evidence="7">
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            <position position="110"/>
        </location>
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        <location>
            <begin position="183"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000498"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00006774"/>
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        <source>
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        <source>
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        <source>
            <dbReference type="HAMAP-Rule" id="MF_01106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH81430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="388" mass="39415" checksum="78B896115BC7BC08" modified="2015-07-22" version="1">MSVTAAKGFTAAGIAAGIKENGNPDLALVVNEGPRRAAAGVFTANRVKAAPVVWSEQVVKGGEVSAVILNSGGANACTGPRGFQDTHATAERVAEVLGHSAAEVAVASTGLIGTLLPMDKLLPGVGLAAAELSAHGGEKAAIAIKTTDTVHKTAVVTAGGDDGAAWTVGGMAKGAGMLAPGLATMLVVLTTDADVPAADLDAALRAATRTTFDRVDSDGAMSTNDTVLLLASGASGVRPPQAEFAEAVRAVCDSLGRQLIADAEGASKEIKIEVVGAAGEDDAVEVGRSIARNNLLKCAIHGEDPNWGRVLAAIGTTSAAFEPDRLNVAINGVWVCKNGSFGEDRELVDMRYREVHIVADLAAGDAEAVVWTNDLTADYVHENSAYSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MZ61</accession>
    <name>A0A0F7MZ61_9ACTN</name>
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        <submittedName>
            <fullName evidence="4">FAD-binding dehydrogenase</fullName>
        </submittedName>
    </protein>
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        <name evidence="4" type="ORF">AA958_04505</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
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        <lineage>
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    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="551" mass="59548" checksum="ADEE008B1DEBD45A" modified="2015-07-22" version="1">MVYDADVIVIGAGLAGLAATAELADAGRKVILLDQEPEQALGGQAHWSFGGLFFVGSPEQRRLRIRDSRELAWQDWLGTAGFDRAEDHWPRKWAEAYVDFASGEKRAWLRAQGMSFFPVVGWAERGGYDAEGHGNSVPRFHITWGTGPGVVAPFERRVREAAELGRVDMRFRHRVTGLARSGGAVDTVTGDILEPSDAPRGTASGREVADTFELRAQAVIITSGGIGGNHDLVRAHWPERLGTPPEKLLSGVPAHVDGLLLDVAGAAGGRLINRDRMWHYTEGIENWNPIWARHGIRILPGPSSLWLDATGRRLPVPLFPGFDTLGTLEHIMKSGHGYTWFVLSQKVIEKEFTLSGSEQNPDLTGKSVRDVLGRAGSGAPAPVQAFMDNGVDFIVERDLATLVRRMNELTGDKLIDEEALRRTLTARDREIDNAYTKDMQITALRGARNFLGDKLIRAASPHRFLDPKNGPLIAVRLNILTRKSLGGLETDLSSRVLAEGGEPLPGVYAAGEAAGFGGGGVHGYRALEGTFLGGCLFSGRAAGRAAAKAVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MZ70</accession>
    <name>A0A0F7MZ70_9ACTN</name>
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        <name evidence="2" type="ORF">AA958_04565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
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    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_04565"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
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        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF00155">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="1">
        <location>
            <begin position="75"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="399" mass="41903" checksum="B22B7F5DC956B93F" modified="2015-07-22" version="1">MSAGTPDAPVADPLRGPTLAELRRRTSVKWRAYPPDVLPLWVAEMDTRLAAPVAEAVRTAVDLGDTGYATVEPYAEAVAEFAGSRWDWRVPTERIALVPDVMRGIAEVLRLVTAPDDAVVVNSPVYPPFYAYTEHLGLRVVEAPLGEDGRIGFAALAEAFASARAGGHRAAYLLCSPHNPTGTVHTAAELARVAALAGEHGVRVVADEIHAPLVPPGARHVPYLTVPGAERGFALLSASKAWNLAGLKSAVAVAGEESAGELALLPQEMSHGASHLGALAHVAAFRHGGPWLDALLAGLDENRRLLGRLLAERLPGAEYRVPDGTFLAWLDCRALGLGDDPAAVFLEYGRVALASGIPFGTGGAGHARLNFATSPEVLTEAVDRMATAVETSPQPGGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MZB6</accession>
    <name>A0A0F7MZB6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PadR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_01490</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_01490"/>
    <dbReference type="EnsemblBacteria" id="AKH81056">
        <property type="protein sequence ID" value="AKH81056"/>
        <property type="gene ID" value="AA958_01490"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_01490"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.327"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="2">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH81056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="127" mass="13929" checksum="FE0934A91B269132" modified="2015-07-22" version="1">MHGYEMIQEISERSGGAWKPSPGSVYPTLQLLEDEGLIVSATEGGKKLFSLTDAGREEAESGPEAPWEDAGRGVDWEALQEVRQSGFALAEAFRQVYTTGTPEQRQEALAVVNDARKKLYLILAEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MZF0</accession>
    <name>A0A0F7MZF0_9ACTN</name>
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        <submittedName>
            <fullName evidence="4">SPFH/Band 7/PHB domain protein</fullName>
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        <name evidence="4" type="ORF">AA958_05045</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS01270">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PHB" evidence="3">
        <location>
            <begin position="21"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="283"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH81665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="320" mass="34957" checksum="3634DDF458ED0633" modified="2015-07-22" version="1">MQPIIIVLIILVVLVFIALIKTIQVIPQASAAIVERFGRYTRTLNAGLNIVVPFIDTIRNRVDLREQVVPFPPQPVITQDNLVVNIDTVIYYQVTDARAATYEVASYIQAIEQLTVTTLRNIIGGMDLERTLTSREEINAALRGVLDEATGRWGIRVNRVELKAIEPPTSIQDSMEKQMRADRDKRAAILTAEGVRQSEILTAEGEKQAAILRAEGEARSAALRAEGEAQAIRTVFESIHAGDPDQKLLSYQYLQMLPKIAEGDANKLWIVPSEIGDALKGLGGALGNFGPPSPTGGGDGAAPKTSTRKAPTYREQPPLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MZI8</accession>
    <name>A0A0F7MZI8_9ACTN</name>
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        <name type="scientific">Streptomyces sp. CNQ-509</name>
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        <lineage>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AKH81715">
        <property type="protein sequence ID" value="AKH81715"/>
        <property type="gene ID" value="AA958_05320"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_05320"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1116"/>
    <dbReference type="OrthoDB" id="996965at2"/>
    <dbReference type="Proteomes" id="UP000034283">
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001853">
        <property type="entry name" value="DSBA-like_thioredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01323">
        <property type="entry name" value="DSBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DSBA" evidence="1">
        <location>
            <begin position="2"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH81715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="234" mass="24836" checksum="7325B02125284D61" modified="2015-07-22" version="1">MRVEIWSDVICPWCYIGKARFEKGLAAFAGRDGVEVVHRSFELSAGAARGGRQELGPELKAKYGWDDAQLKAMEDRVGAAAAAEGLGMRHDRFVTGTFDLHRVLHLAKECGLQDRLLDAFYTANFAEARPISEDDTIVDIATGAGLDADEVRRVLADEDAYADAVRADEKEAAELGATGVPFFVIDRRFAVSGGQPAQVFTQALEQAAAAGGLQTVAGTGGDGAVCADDACDVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N041</accession>
    <name>A0A0F7N041_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_06630</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
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        <lineage>
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            <taxon>Actinobacteria</taxon>
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        </lineage>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015292.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_06630"/>
    <dbReference type="EnsemblBacteria" id="AKH81940">
        <property type="protein sequence ID" value="AKH81940"/>
        <property type="gene ID" value="AA958_06630"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_06630"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1383"/>
    <dbReference type="OrthoDB" id="1752144at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041098">
        <property type="entry name" value="Rv2175c_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18367">
        <property type="entry name" value="Rv2175c_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_17" evidence="1">
        <location>
            <begin position="15"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="Rv2175c_C" evidence="2">
        <location>
            <begin position="65"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH81940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="121" mass="13168" checksum="996786731C5B02A5" modified="2015-07-22" version="1">MTEIDAKIDALVPSWLTLPDVAEKLGVEVTRVRQLVREGQLIAVRRGENNALHVPAEFIGEGKVIKGLTGTLTLLKDDGFSDAEALEWLFTPDPSLPGTPAQALRENRGTEVKRRAQALAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N065</accession>
    <name>A0A0F7N065_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phage-shock protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_06915</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PspA/IM30 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015341.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_06915"/>
    <dbReference type="EnsemblBacteria" id="AKH81990">
        <property type="protein sequence ID" value="AKH81990"/>
        <property type="gene ID" value="AA958_06915"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_06915"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1445"/>
    <dbReference type="OrthoDB" id="941029at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007157">
        <property type="entry name" value="PspA_IM30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31088">
        <property type="entry name" value="PTHR31088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04012">
        <property type="entry name" value="PspA_IM30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="229"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="48"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH81990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="269" mass="29506" checksum="D1A7B04605303820" modified="2015-07-22" version="1">MSGVMKRMGMIFRAKANKALDRAEDPRETLDYSYQKQLELLQKVRRGVADVATSRKRLELQLGQLQNQSAKLEDQGRKALALGREDLAREALSRKAALHQQVTDLETQHQTLQTEEEKLTLAAQRLQAKVDAFRTKKETIKATYTAAQAQTRIGEAFSGISEEMGDVGLAVQRAEDRTAQMQARAGAIDELLASGALDDPTGMAKDDISAELDRLSGGADVELELQRMKAELAGGPAEQQQAIEGGRQGAQTPPQQQAPPQDAPRFDKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0G7</accession>
    <name>A0A0F7N0G7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_00140</name>
        <name evidence="2" type="ORF">AA958_34115</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH80839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP011492">
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        <property type="protein sequence ID" value="AKH86432"/>
        <property type="gene ID" value="AA958_34115"/>
    </dbReference>
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    <dbReference type="KEGG" id="strc:AA958_34115"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.31"/>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH80839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="61" mass="6590" checksum="BEA6A0F56690E1B0" modified="2015-07-22" version="1">MRWPKSNSTRAAADVAGAAEAELRDLPGAGLGHAYFQDRCRRAAGLEVMVTDIDHLHVDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0J8</accession>
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    </protein>
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    </gene>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
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    </dbReference>
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            <begin position="189"/>
            <end position="212"/>
        </location>
    </feature>
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            <begin position="1"/>
            <end position="20"/>
        </location>
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            <begin position="27"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="139"/>
            <end position="159"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
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            <dbReference type="EMBL" id="AKH82160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="231" mass="23327" checksum="02E66AD5CA31266E" modified="2015-07-22" version="1">MGDAPRRRPGRERFVTGTGERDETAGKPAGNSPDREGEHTGAAARGVVAPGSGSGESAPEGSGAAAAGEPSRAGSPGVLVPAAPAADRAGPAKGGPATTDPVATAGHVAADPVAVADPVAPAPAAPPSAPGHGRRPDGPLLPPSERDEWGDRLHRATGRFVDDPPGAVDDACAVLGDLGERIAALLAERRDASRDLTRQARTTDGEANAQTERLRLALRDSRDLAERLLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N162</accession>
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        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
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    <dbReference type="EnsemblBacteria" id="AKH81114">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
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    </dbReference>
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            <begin position="139"/>
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        </location>
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    </feature>
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            <begin position="295"/>
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        </location>
    </feature>
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        <location>
            <begin position="334"/>
            <end position="352"/>
        </location>
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        <location>
            <begin position="372"/>
            <end position="391"/>
        </location>
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        <location>
            <begin position="403"/>
            <end position="425"/>
        </location>
    </feature>
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        <location>
            <begin position="451"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="524"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="565"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="718"/>
            <end position="739"/>
        </location>
    </feature>
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        <location>
            <begin position="785"/>
            <end position="821"/>
        </location>
    </feature>
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        <location>
            <begin position="56"/>
            <end position="84"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH81114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="821" mass="86076" checksum="3399C8A81EF00A4E" modified="2015-07-22" version="1">MQPEALSAKGRTPPGGTGGSEGTAPQPALELLVHGVGGATPQEMLGDPRTELVTGDRTAGIHRRTDDVRAEEPAGERRGEGGGPRTEPVQEAYCWSNLTSGNGARALWLVLLPFMIANLAHWMRPAAPSRHGAHRAYDVLVRIFALTLTVQLVLAAGEVTLDLLAWQCAGSTHCVADKSWLGFMSAESGGWFGGPGRRLALAALVPVLLTALLWWLSRRTWSIYESAKPSPRAGAPGTTGEQPALSLPGFWYGRRLVARLRAAHTATGLLAVASALIAVTVAADDDTGGGLRATGWVLGALTAAGWIAVVALVCRSGRTEAEPDMGEDRRAVRAVPLAALALLAAVLVHTAWSRPGWVSTGRLPGTSVFGGLAVAQGVLAAGLAVTGLLLQRRATGEPPALRGLGGACVALLASAVAGVFSGGVAQRVADWLDRGATPGENGPLAGPPVVLSWQATAIPLIALLVLLLALAGGWRMWVLRRRIATEVAGLYPTEHRYTGDNDPRTGRIAGAIARARLTDDAPPALGAAALATLVLGAGAVLGAWLTDEVPGKAARGAPGPLPGLAQTGQALGSWMMGAGVILLLAMGRQAYRDPKSRRTVGILWDVGTFWPRAAHPFAPPCYAERAVPDLAWRTSTWTSRTGGCLVISGHSQGSVLAAAAVWQLDPDIRGRVALLTYGSPLRRLYGRWFPAYFGDRALAELDDQTHAWRNLWRLTDPIGGPVRPTPPDGRPSDVDRKPLKDPLAFERTPEHPLPAAINAHSDYQADPAFAVERAELIARISVAPAAPVEEWPRQVPRPAGEPDAETADGAAVQGRTGMSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N171</accession>
    <name>A0A0F7N171_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AA958_05605</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015115.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_05605"/>
    <dbReference type="EnsemblBacteria" id="AKH81761">
        <property type="protein sequence ID" value="AKH81761"/>
        <property type="gene ID" value="AA958_05605"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_05605"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1174"/>
    <dbReference type="OrthoDB" id="1552415at2"/>
    <dbReference type="Proteomes" id="UP000034283">
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    </dbReference>
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        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
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        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="117"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="150"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="242"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="9">
        <location>
            <begin position="33"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AKH81761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="263" mass="26626" checksum="11ACCAD572BF9986" modified="2015-07-22" version="1">MSARQAGTGVYAPRPGAAPLRRMVAAQAGLETRLLLRNGEQVLLTMIIPAVLLLLFSTVDVVDTGPGQRVDFLAPGAIALAVLATAFTGQAIGTGFDRRYGVLKRLGASPLPRAGLMAAKAAAVLATIVLQLVLLTAIALALGWSPRGGAGGALAVVLLVALGTAAFSGLGLLMAGTLRAEATLAAANLVFVLLLVAGGVIVPLEKFPDGARAVLEVLPVAALSDGLRGVLQDGGGMPWGEVGLLAGWAVLGLAAAARFFRWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N184</accession>
    <name>A0A0F7N184_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD-dependent glyceraldehyde-3-phosphate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AA958_05695</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNQ-509</strain>
        </source>
    </reference>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="3"/>
            <end position="153"/>
        </location>
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        <location>
            <begin position="152"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Glyceraldehyde 3-phosphate binding" evidence="6">
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            <begin position="211"/>
            <end position="212"/>
        </location>
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    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="12"/>
            <end position="13"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
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        <location>
            <position position="35"/>
        </location>
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        </ligand>
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        </ligand>
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            <position position="183"/>
        </location>
        <ligand>
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        </ligand>
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        </location>
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    </evidence>
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="AKH81776.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
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    </evidence>
    <sequence length="334" mass="36006" checksum="CD427D4429F56CE0" modified="2015-07-22" version="1">MTIRVGINGFGRIGRNYFRAILEQGADIEVVAFNDLGDAATIAHLLKYDTLLGKLKAEVSHSADAITVDGRPIKMLAERDPANLPWGDLGVDVVIESTGIFTKSEDAKKHLDAGAKKVIISAPAKGEDITIVMGVNEDSYDPAAHHIISNASCTTNCVAPMAKVLDENFGIVQGMMTTVHAYTNDQRILDFPHKDLRRARAAAENIIPTTTGAAKATALVLPQLKGKLDGIAMRVPVPTGSVTDLVVELGREVTKDEVNAAYQKAAEGQLKGILEYTEDPIVSSDIVNTAPSCTFDSLLTMAQGKQVKIVGWYDNEWGYSNRLVDITTFVGERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N1B8</accession>
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        </submittedName>
    </protein>
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    </gene>
    <organism evidence="3 4">
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                <person name="Albersmeier A."/>
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                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">CNQ-509</strain>
        </source>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="23"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH82335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="127" mass="13382" checksum="824C26C06A589188" modified="2015-07-22" version="1">MTTTAYAPARTVLRVEIRTAAGWHPVCELALLTRGRGVAALLPDGTQVAVFLGRTGNAYAIGNRDPFTGAYVLSRGLLGSAPPAEGGRPFVASPLLKQRFDLATGRCLDDEEVAVPAYETRIAEVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N230</accession>
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        <submittedName>
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    <gene>
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    </gene>
    <organism evidence="4 5">
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        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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                <person name="Albersmeier A."/>
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                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <source>
            <dbReference type="ARBA" id="ARBA00010529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH82660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="93" mass="9888" checksum="6DC643A9CD81EE0A" modified="2015-07-22" version="1">MNRSELVAAIAERAEVTRKDADAVVAALAEVAGEVVSKGDERITIPGFLTFERTHRKARSARNPQTGEPIQIPAGYSVKVTAGSKLKEAAKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N260</accession>
    <name>A0A0F7N260_9ACTN</name>
    <protein>
        <submittedName>
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        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">AA958_00865</name>
    </gene>
    <organism evidence="2 3">
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        <lineage>
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            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH80957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
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        <location>
            <begin position="60"/>
            <end position="128"/>
        </location>
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    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH80957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="172" mass="19434" checksum="73B7131F247A97A6" modified="2015-07-22" version="1">MSYPEDLVYPEPRYHGERGEVNATFRPAGSPPDLTSPGGFTRYLATEESTGGEFGLYDVQLGPRSPGAKTHFHKAMSESFYVVSGELELYDGDRWVTGRGGDFLYVPVGGLHAFRNATDDPVRVLMLFSPGAPREEYFERVAEMSRRGGEELKRFRIRHDSFFVEDFEHDAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2A5</accession>
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        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
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    <gene>
        <name evidence="10" type="ORF">AA958_04180</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
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        </lineage>
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    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="AA958_04180"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_04180"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.877"/>
    <dbReference type="OrthoDB" id="2037979at2"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="ChpA-H"/>
    </dbReference>
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        <property type="entry name" value="LPXTG_anchor"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="5" id="KW-0572">Peptidoglycan-anchor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="23"/>
            <end position="63"/>
        </location>
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            <begin position="88"/>
            <end position="128"/>
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    <feature type="domain" description="GRAM_POS_ANCHORING" evidence="8">
        <location>
            <begin position="195"/>
            <end position="230"/>
        </location>
    </feature>
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        <location>
            <begin position="72"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="126"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
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            <begin position="142"/>
            <end position="156"/>
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        <location>
            <begin position="163"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023088"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01232"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51884"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AKH81523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="230" mass="22320" checksum="6A6140DAE3C0432D" modified="2015-07-22" version="1">MLVAAGATAAQADAGAEGAATNSPGVGSGNTVQAPVNVPVNVCGNTVNAGGLLNPAFGNTCVNDGGGTKTGGHATGGGAQAQGQSSQSPGVLSGNTAQAPVDVPVNACGNSANVVGVGNAAFGNECGNGAVPDTPKPPKPEEPPTTPEEPDRPDVPDTPEQPVTPDRPDEPTDRSHTPPNHETQAGAPAPETEQLAETGSEIPVGALIPLSGGLLLGGAVLYRRARAAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2H0</accession>
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    </gene>
    <organism evidence="3 4">
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            <taxon>Bacteria</taxon>
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        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
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        <property type="project" value="UniProtKB-KW"/>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="194"/>
            <end position="220"/>
        </location>
    </feature>
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        <source>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="AKH82196.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="220" mass="23914" checksum="778793AD183139D5" modified="2015-07-22" version="1">MAEQDHVMESLPHPLAEPPKEHVPGSREALKDRVNVGHPAHQHTKLDEHLPVDHHLSNVYRVGAGLAGLFLLVFGILGLIDRIGFFDTGGHQTLGLNSNGALSVLSIVAGVVLLYGMVRGGNFASTLNMVLGGLFVLSGFVNLAVLDTSWNFFAFRMQNVLFSFILGVVLAMFGMYGRVSGRLPHDNPYWRTRNAEEAAAEDEETAEDEEARAATGAARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N327</accession>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
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        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_13335"/>
    <dbReference type="EnsemblBacteria" id="AKH83050">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="1 2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="298" mass="32090" checksum="E0489C37A149BA9C" modified="2015-07-22" version="1">MTHTDETDDRLYVPGGAAASGPYRTAITPTTAGWGYSGLRILELAPGRSHTLATGDAEHLVLPLAGGCTVEADGTRLDLTGRAGVFGDPTDFAYVPRDTDVRISSPGGGRFALPSARCERRLPVRYGPAAGVPVELRGAGTCSRQVHNYCLPQTFDADRLLVCEVLTPGGNWSSYPPHKHDEARPGEESELEEIYYFEVAEGPHGGPGMAYQRVYGTADRPLDVLAEVRSGDTVLIPHGWHGPSMAVPGYDLYYLNVMAGPGAERAWLICDDPAHGWIRSTWDDQDTDPRLPFGGGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-08-12" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N385</accession>
    <name>A0A0F7N385_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Stress protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_09775</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asp23 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015814.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH82471">
        <property type="protein sequence ID" value="AKH82471"/>
        <property type="gene ID" value="AA958_09775"/>
    </dbReference>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH82471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="161" mass="16724" checksum="73A4162FF54437D3" modified="2015-07-22" version="1">MADEAEEVRSGGRQSGEGGRAGSAGRHVAPGDRGRTTIADGVVEKIAGLAARDVPGVHAMGGGMARTLGAVRDRVPGDSRSRSTVTRGVKAEVGEVQCALDLDLVVDYGFAIADLASEVRQSVIAAVERMTGLEVVEVNIAVDDVKLPDEEDEEGDGRTIR</sequence>
</entry>
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            <authorList>
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">CNQ-509</strain>
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    <evidence type="ECO:0000259" key="1">
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        </source>
    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="331" mass="33065" checksum="35743F5E78AFB3C0" modified="2015-07-22" version="1">MGVSPVAVLAIDAGNSKTDAALVAADGTVLGQGRSGGFRPPVAGAAAAVDVLAEAVAGAVRQAGGDGSGGAVAAHVSACLANVDLPVEERTVRAELEARGWGRTVAVHNDTFAVLRAGLPPGAQPRGVAVVCGAGINCAGLLPDGRTHRFLALGKLSGDWGGGAGLAAEAVWYAARAEDGRGEPTALATAVPEHFGLGTMYELIEGVHLGRVPVARTQRLAPLLFAVAAAGDPVARSIVDRQADEVVALAAVALERLGLLDEEVPVVLGGSVLAAGHAQLDDRIRAGLTARAPKAVPRVVTAPPVLGAALLGLDRTDAPEGAGSRTRAHYG</sequence>
</entry>
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                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
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</entry>
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    <accession>A0A0F7N3F0</accession>
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        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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    </dbReference>
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        <location>
            <begin position="32"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="168" mass="18818" checksum="1097FE84A8FCC811" modified="2015-07-22" version="1">MANEVAPAVIAATTSLPPELAVAAVPEDERVWVPQAPDVWFRPLLFNTVTGQWCNLLKVTAAGIVSRHRHPGAVFGYVIKGKWHYYEHPWVAEQGHFVYEPPGEIHTLAVPEDCAEMITFFNISGAMIYLDEENRNTGYEDVFTKIDMARAHYAANGLGADYVDQFIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3Q5</accession>
    <name>A0A0F7N3Q5_9ACTN</name>
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        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
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        <reaction evidence="5">
            <text>a quinol + 2 Fe(III)-[cytochrome c](out) = a quinone + 2 Fe(II)-[cytochrome c](out) + 2 H(+)(out)</text>
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            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
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            <dbReference type="ChEBI" id="CHEBI:15378"/>
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            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="7.1.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
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            <name>heme</name>
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        </cofactor>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_06820"/>
    <dbReference type="EnsemblBacteria" id="AKH81973">
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        <property type="gene ID" value="AA958_06820"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_06820"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1426"/>
    <dbReference type="OrthoDB" id="262439at2"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008121">
        <property type="term" value="F:ubiquinol-cytochrome-c reductase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cyt_b/b6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027387">
        <property type="entry name" value="Cytb/b6-like_sf"/>
    </dbReference>
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        <property type="entry name" value="Di-haem_cyt_TM"/>
    </dbReference>
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        <property type="entry name" value="Cytochrom_B_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF81342"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CYTB_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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    <feature type="transmembrane region" description="Helical" evidence="7">
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="238"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="7">
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    <feature type="transmembrane region" description="Helical" evidence="7">
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="7">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="417"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="CYTB_NTER" evidence="8">
        <location>
            <begin position="19"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH81973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="544" mass="61167" checksum="F46EA39C9FE7C422" modified="2015-07-22" version="1">MSTTTTDTRRKPPGRGERVADWADARLGLHAAGRKNIRKVFPDHWSFLLGEVAMYTFLIVLLTGVYLTLFFKPSMAEITYHGSYAPMNGVHMTEAYASTLDISFDVRGGLLIRQIHHWSALIFIAAMATHMMRVFFTGAFRKPREVNWLFGFTLLVLGCIAGFTGYSLPDDLLSGTGVRFMEGATLATPVVGTYLAFFLWGGEFPGTDIIPRFFAIHVLLVPGIMLGLFVLHLILVFYHKHTQFAGAGKTNDNVVGAPFMPIYVAKAGGFFFLVFGVVAVIAGMFTINPVWDLGPYRPDLVSTGAQPDWYMGWTEGLIRFMPGWEWVIPGGYTINFGVFIPLMIVGVVPIAMVAYPFFETWVTGDHREHHTLDRPRNVPTRTAYGVAWLTWVFVLLMGGGNDLWATHFHLSIESITWFVRVSFFVAPVVAFWITRRICLGLQRRDREKVLHGRETGIIKRLPHGEFIEVHESLSQEEMHKLTAHDQYTPLELGPTVDDNGVVRKQGPVEKLRARLSQGYYGEAGQIAKPTRREYEEITSGHGHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3U5</accession>
    <name>A0A0F7N3U5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Cell division protein FtsX</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AA958_11150</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Part of the ABC transporter FtsEX involved in cellular division.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ABC-4 integral membrane protein family. FtsX subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016034.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_11150"/>
    <dbReference type="EnsemblBacteria" id="AKH82696">
        <property type="protein sequence ID" value="AKH82696"/>
        <property type="gene ID" value="AA958_11150"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_11150"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2349"/>
    <dbReference type="OrthoDB" id="1653234at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004513">
        <property type="entry name" value="ABC_transpt_FtsX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040690">
        <property type="entry name" value="FtsX_ECD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47755">
        <property type="entry name" value="PTHR47755"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18075">
        <property type="entry name" value="FtsX_ECD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003097">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8 11" id="KW-0132">Cell division</keyword>
    <keyword evidence="4 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="177"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="221"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="274"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="10">
        <location>
            <begin position="26"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR003097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AKH82696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="303" mass="33619" checksum="0DFF4A78DD822CD6" modified="2015-07-22" version="1">MRAQFVFSEIGVGLRRNLTMTFAVIVSVALSLALFGASWLMGKQVDTMKGYWYDKVNVSIFFCNEVDAETSPNCERGAVTAEQKKEIQDDLKALDVVESVHYESSEEAYKHYKEQFGDSPLASSLTPDQMQESFRVKLTDPERYEVITSAFADRPGVQEVQDQRNVLESLFNLLNGMTYAAIGVMALMLVVAIMLIVNTVRVSAFSRRRETGIMRLVGASSVYIQLPFIVEAAVAGLIGASFAAVLLVGGKHFLIDNWLADKILLINFIGWDEVIRVLPLVVAIGLLMPGIAAFFALRKYLKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N3Y1</accession>
    <name>A0A0F7N3Y1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Bifunctional F420 biosynthesis protein FbiB</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="10">Coenzyme F420:L-glutamate ligase</fullName>
                <ecNumber evidence="10">6.3.2.31</ecNumber>
                <ecNumber evidence="10">6.3.2.34</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="10">Coenzyme F420-0:L-glutamate ligase</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="10">Coenzyme F420-1:gamma-L-glutamate ligase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="10">Dehydro-coenzyme F420-0 reductase</fullName>
                <ecNumber evidence="10">1.3.8.17</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="10" type="primary">fbiB</name>
        <name evidence="14" type="ORF">AA958_11405</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Bifunctional enzyme that catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives, and the FMNH2-dependent reduction of dehydro-F420-0 to form F420-0.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>FMN + H(+) + oxidized coenzyme F420-0 = dehydro coenzyme F420-0 + FMNH2</text>
            <dbReference type="Rhea" id="RHEA:60360"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:59907"/>
            <dbReference type="ChEBI" id="CHEBI:143705"/>
            <dbReference type="EC" id="1.3.8.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>GTP + L-glutamate + oxidized coenzyme F420-0 = GDP + H(+) + oxidized coenzyme F420-1 + phosphate</text>
            <dbReference type="Rhea" id="RHEA:30555"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:59907"/>
            <dbReference type="ChEBI" id="CHEBI:59920"/>
            <dbReference type="EC" id="6.3.2.31"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>GTP + L-glutamate + oxidized coenzyme F420-1 = GDP + H(+) + oxidized coenzyme F420-2 + phosphate</text>
            <dbReference type="Rhea" id="RHEA:30523"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57922"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:59920"/>
            <dbReference type="EC" id="6.3.2.34"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="10">Monovalent cation. The ion could be potassium.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="10">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="10">Binds 2 divalent metal cations per subunit. The ions could be magnesium and/or manganese.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Cofactor biosynthesis; coenzyme F420 biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">In the N-terminal section; belongs to the CofE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.31" evidence="10"/>
    <dbReference type="EC" id="6.3.2.34" evidence="10"/>
    <dbReference type="EC" id="1.3.8.17" evidence="10"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016072.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_11405"/>
    <dbReference type="EnsemblBacteria" id="AKH82736">
        <property type="protein sequence ID" value="AKH82736"/>
        <property type="gene ID" value="AA958_11405"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_11405"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2400"/>
    <dbReference type="OrthoDB" id="1847197at2"/>
    <dbReference type="UniPathway" id="UPA00071"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052618">
        <property type="term" value="F:coenzyme F420-0:L-glutamate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052619">
        <property type="term" value="F:coenzyme F420-1:gamma-L-glutamate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052890">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052645">
        <property type="term" value="P:F420-0 metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01259">
        <property type="entry name" value="F420_ligase_FbiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008225">
        <property type="entry name" value="F420-0_g-glutamyl_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002847">
        <property type="entry name" value="F420-0_gamma-glut_ligase-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019943">
        <property type="entry name" value="F420_FbiB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023661">
        <property type="entry name" value="FbiB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01996">
        <property type="entry name" value="F420_ligase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01916">
        <property type="entry name" value="F420_cofE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03553">
        <property type="entry name" value="F420_FbiB_CTERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 10 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 10" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 10" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 10" id="KW-0630">Potassium</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F420_ligase" evidence="13">
        <location>
            <begin position="33"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="F420_ligase" evidence="13">
        <location>
            <begin position="108"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Nitroreductase" evidence="12">
        <location>
            <begin position="273"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Coenzyme F420:L-glutamate ligase" evidence="10">
        <location>
            <begin position="1"/>
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</entry>
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                <person name="Kalinowski J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
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    </dbReference>
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        <location>
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            <end position="84"/>
        </location>
    </feature>
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            <begin position="62"/>
            <end position="76"/>
        </location>
    </feature>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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    </evidence>
    <sequence length="84" mass="9108" checksum="1CC3D28D36F74C96" modified="2015-07-22" version="1">MPGETDIRPWGLTRMRPYPAAAVLPAVAVVLDPDTQTGRWIDVDGTPVPATDRHRRSETSRETSTLTSLDGNSDQGSDQEGDTD</sequence>
</entry>
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    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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                <person name="Leipoldt F."/>
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                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5 6">CNQ-509</strain>
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</entry>
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                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
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            <strain evidence="3 4">CNQ-509</strain>
        </source>
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    </evidence>
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    <sequence length="268" mass="28043" checksum="EB1AD4F42C93E0B6" modified="2015-07-22" version="1">MSGDVVREWREAAADDRAVLLDGFHALKHALRFGARVRIAVTASRADARALAGELAPDLADRLDSLLAEVPDRELRELVPRRHPTGIAALADRPEPAAVRAALRAPRSAPVVVLDNPRNLGNVGAVVRLAAGMGATGVVTTGDADPWHPHAVRGAAGLHYATAVARLPLGDLPDAAPGPLYALDPAGDDLRTLRLPPGALLAFGSERHGISPALRTRADRLVSLPMRPQVSSYNLATSVAMTLYHWSQTDGPDTGDGPGVPAQTSGST</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N4H7</accession>
    <name>A0A0F7N4H7_9ACTN</name>
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        </submittedName>
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    </gene>
    <organism evidence="8 9">
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                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
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    </dbReference>
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    </dbReference>
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        </location>
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        </location>
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        </location>
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        </location>
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        </location>
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        </location>
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        </location>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="478" mass="48792" checksum="AF91EE50D66FF815" modified="2015-07-22" version="1">MTDTATTVAEDGRADRPGQSSGPGLTLLALASAGLVVSLQQTLVLPLLPQLMQTFDISVAAVSWVFTATLLAGAVATPLLSRFGDMYGKKKMISVTMGLLVAGSVICAIADSLALLIVGRALQGTAAAVIPLAIGMIRDSYPREKVTTAIGVVSATLGVGGAVGMLVTGLIADNTDSHHPVFWIAAAMAAVGLLFVLFCTRDSGRRAGGRPDLIGAALLGGWLVSLLIGISQGNSWGWTDARILGLFAAAVVLCAVWVAVELRMREPLVRLQILVGPKSLSANLASLLLGFSMFAAFTLISNFIQTPEAEVGYGLTGSVLDVGLYMLPSTLTMLVFSTLSGRIEARIGAAWTLATGSVIAGVAYAWLALMHDSALDIMIFSGIQGLGIGIAYAALGTLAVQHVPMDQSGIASGINSLVRTAGGSIASAATAAVLAAQVIDGTEVPTVDAYVLCFVIAGLSAGAAAAIAAVHGLRHGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5C5</accession>
    <name>A0A0F7N5C5_9ACTN</name>
    <protein>
        <recommendedName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AA958_06980</name>
    </gene>
    <organism evidence="12 13">
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        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>(R)-N(6)-lipoyl-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase] + H(+) + pyruvate = (R)-N(6)-(S(8)-acetyldihydrolipoyl)-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase] + CO2</text>
            <dbReference type="Rhea" id="RHEA:19189"/>
            <dbReference type="Rhea" id="RHEA-COMP:10480"/>
            <dbReference type="Rhea" id="RHEA-COMP:10481"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="1.2.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
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    <dbReference type="PATRIC" id="fig|444103.5.peg.1459"/>
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        <property type="term" value="F:metal ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="term" value="P:glycolytic process"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="TPP_E1_EcPDC_like"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
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        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
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        <property type="entry name" value="PTHR43825:SF3"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00759">
        <property type="entry name" value="aceE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8 12" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="TRANSKETOLASE_1" evidence="10">
        <location>
            <begin position="143"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="PDH_E1_M" evidence="11">
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            <begin position="484"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
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        <location>
            <position position="266"/>
        </location>
        <ligand>
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            <position position="268"/>
        </location>
        <ligand>
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        </ligand>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        </source>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00033635"/>
        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
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        </source>
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            <dbReference type="Pfam" id="PF17831"/>
        </source>
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            <dbReference type="EMBL" id="AKH82002.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="897" mass="98026" checksum="69B0A189C8CA86D9" modified="2015-07-22" version="1">MQSQLDQLPDRDPQETAEWRESLDAVVRHAGPDRAAQVLRRTVAHAGDAGLDVPALLETPYVNTIPTAAEPELPGDPELERRVAAWNRWNAAAMVTRGSRFGLGGHIATFASAAWLYETGFNHFFRGKDDPRAPGSGDQLYIQGHASPGVYARAFLDGRLTEAHLDRFRQEAAPGAVEGLPSYPHPRRLPWLWEFPTVSMGLGPISAIYQARFNRYLAHRGIKDTSASHVWAFLGDGEMDEPESTAALALAAREQLDNLTFVINCNLQRLDGPVRANFKVVQELEAQFRGAGWNVVKSLWGSAWDELLALDTTGALARRLREVPDAQFQTYATRDAAYIREHFFGAEPALAELAKLIGDDKILECFHLSRGGHEPRKVYAAYRAAVAHEGAPTVILAQTVKGHTLGKGFESRNANHQMKKLTGAEFRDMRDLLELPIPDSALAGDLVPYAHPGPGSPEVRYLQERRAALGGPAPARRVHPVVLPEPAAKPFDALKKGSGSQEIATTMAFVRLVKDLMREKETGRRWVPVVPDEARTFGMESLFPSAGIYSPRGQTYDPVDRDQLLYYKEAANGQILNEGITEAGSLASFTAAATSYATHGEPMIPFYIFYSMFGFQRTGDQFWALADQLGRGFVIGATAGRTTMTGEGLQHADGHSPLLASTNPAALIYDPAFAYEVAVIVKDGLRRMYGAAAPGEDPDVFYYLTVYNEPKVQPPMPAGVEEGIVRGLYRYRTADTPAGAAAEDAPRAQVLASGTAIHWALDAQRLLAEDWGVAADVWSATSWSELRRDALSCDAAQLRGEDRVPYVTRALEGAPGPVLAVSDWMRQVPDQIAQWVPQEYTSLGTDGFGLSDTREAARRHFGVDPESIVVAVLDRLARRGEVKKETVAAAAAKYGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5K0</accession>
    <name>A0A0F7N5K0_9ACTN</name>
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        <recommendedName>
            <fullName evidence="2">PPM-type phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">AA958_11030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
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                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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    </dbReference>
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            <end position="39"/>
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            <end position="79"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="113"/>
        </location>
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            <begin position="144"/>
            <end position="368"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH82673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="372" mass="40426" checksum="F41DD2D40F57F890" modified="2015-07-22" version="1">MARPPEEGGIPRRTGAQEKWLPALPPLLLFTGLLIGLFTPSDVRPIAFLATAMVSAAALLPLWETVLTGVGACAIFFVLMVHFNALRDVTAYSELATVAAIAVFAVFLNRLLARRARQLVQVRSVAETAQLAVLHPLPHHLGHVTLESMYLAAAAEARIGGDLYGAVRTPHGVRLLIGDVRGKGLPAIQAAATLLGAFRESAHDAPDLPHLARRLETSISRYASQHPGVLGSEIAERFITALLAEIPDHELVVRTLTCGHPPPLLLHRGEVRELQADAPSPPLNLGMLVNDEFHVDLTPFHPGDQLLLYTDGVTETRDRSGAFYPLAERIRPWSGETPRHLLKHLHRDLVAYSDGELDDDVAAVIARRRASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N5K3</accession>
    <name>A0A0F7N5K3_9ACTN</name>
    <protein>
        <submittedName>
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    </protein>
    <gene>
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    </gene>
    <organism evidence="1 2">
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        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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    </dbReference>
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    </dbReference>
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    <dbReference type="PATRIC" id="fig|444103.5.peg.2340"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH82689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="314" mass="32665" checksum="5947E0C82EA5A9DD" modified="2015-07-22" version="1">MTDYTGSGPYCYANSLVMSLPDAVAGPAPSPALVETLTGSPFGVQLLGGTVPLFDPYGWDPEIGLDDAVALLGFRCDRTSGGSADEAMARLRTACARGPVLVGPVDMGLLLYHPGTPWSPSAGGNDHYVVALAADGDTVLLHDPHGHPYATLPAGEFLASWRAEAVEYTAEPYVMRAGFERVRTVTAEEAVRAALPGAVAWLAVRTDLPVPPGTVGGAEALERLADRAAAGLDAGVRELLADFAVRVGARRLADASAYVRRAGLDRAAAVLQEQARLVGAVQYPLVRGDGAALAAVLRRLAPTYGRLREVLAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N653</accession>
    <name>A0A0F7N653_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sugar ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_08815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015659.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_08815"/>
    <dbReference type="EnsemblBacteria" id="AKH82312">
        <property type="protein sequence ID" value="AKH82312"/>
        <property type="gene ID" value="AA958_08815"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_08815"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1857"/>
    <dbReference type="OrthoDB" id="1303718at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519179" evidence="1">
        <location>
            <begin position="21"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="425" mass="44491" checksum="053B87B84DEA750E" modified="2015-07-22" version="1">MRRGIAATALAASLALVATACGDDGGDGGSAGGQVTITWWDTSNATNEAPTYKALIKEFEKAHPDIKVEYVNVPFDQAQNKFTTAAGTKGAPDVIRTEVGWTASWAKSQFLAPLDGTAALGKQDDFTPSLLKQAQYEGTTYGAPIVTDTLALLWNKDLLKKAGHDAPPADWDQLMDVAADVEKKTGADGFWLHKDPYYTLPFLFGEGTDMVDAEAQKITVNSPGAVTGVEKAKEIVDAPGTADLDVTADAYAHMQDAFVNGKVAMIIQGPWELTNVYAGSAFKDKADLGIAPVPAGSTGKAGAPTGGHNLSVYNGSDEAHKEAAIEFTGWMTSADTQAKIAVENGTLPTRASAYTAEVKAAPGVADYQQVLADTAQPRPALPEYSTLLGDDFAQNLAAVLKGDTGVKAGLDATAEKFGELVPDFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6A2</accession>
    <name>A0A0F7N6A2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_12585</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016263.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH82928">
        <property type="protein sequence ID" value="AKH82928"/>
        <property type="gene ID" value="AA958_12585"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_12585"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2644"/>
    <dbReference type="OrthoDB" id="1363223at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0814">Transposable element</keyword>
    <feature type="domain" description="DDE_3" evidence="2">
        <location>
            <begin position="174"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH82928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="362" mass="41803" checksum="68130DFB3A57A939" modified="2015-07-22" version="1">MPGPKPLPVVLSDEELRVLRRWLRKQTAAQALVLRSRIVLACAEGLPNAQVAEDLGISRETVRKWRARFVKDRLEGLTDRPRPGPPRRITDEQVEALVTKTLDEKPSSGDSHWSTRSMAEATGMSQSAVSRIWRAFGLKPHTVETWKLSTDPEFVTKVRDVVGIYLCPPENALVLAVDEKSQIQALDRTQPVLPMAPTTPARMTHDYVRHNTTSLFAALDIAFRSVIAQHYRRHRHTEFLRFLKTIDAAVPKDLDLHLVLDNYATHKTEAAKKWLLRHPRFHLHFTPTSASWLNLVERWFAELTRRKLRRSAHRSVIELERDIRGWINEWNKNPKPFVWTKTADEILENLAAYCQRINDSRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6A5</accession>
    <name>A0A0F7N6A5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aromatic prenyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_12635</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aromatic prenyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_12635"/>
    <dbReference type="EnsemblBacteria" id="AKH82933">
        <property type="protein sequence ID" value="AKH82933"/>
        <property type="gene ID" value="AA958_12635"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_12635"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2654"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd13931">
        <property type="entry name" value="PT-CloQ_NphB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033964">
        <property type="entry name" value="Aro_prenylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020965">
        <property type="entry name" value="Prenyltransferase_CloQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036239">
        <property type="entry name" value="PrenylTrfase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11468">
        <property type="entry name" value="PTase_Orf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00036">
        <property type="entry name" value="Aromatic_Prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01163">
        <property type="entry name" value="II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143492">
        <property type="entry name" value="SSF143492"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH82933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="300" mass="32987" checksum="2B6DFE6196FA4A0A" modified="2015-07-22" version="1">MSSPAENLYAAIEKTAGLVDVPCAREKVWPILSAFEELLPQAAILFRVATDARHAGEINCHMMMLPSTIDPHALAQANGLLPRKDHPIDSLLGDIEAGFPIGSYGVDFGLVGGFQKAWSCFPGEQMQSLPKLAALPSMPPSVAGNMDFFERYGLAEKITLIGMDYGHRTMNVYFGEVDDCLTPAAVRSMLSDIGMPEPSEHLLTFAQQAFGFYTTLSWDSPDIERFCYSAITPDPLAILDRVEPKIEHFLREIPYGADNPKAVYVATSPGDGEYCKVQSYYQWRPRLVNHMHTTAPPASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6J4</accession>
    <name>A0A0F7N6J4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_12840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_12840"/>
    <dbReference type="EnsemblBacteria" id="AKH82964">
        <property type="protein sequence ID" value="AKH82964"/>
        <property type="gene ID" value="AA958_12840"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_12840"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2701"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH82964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="376" mass="39684" checksum="BE6213F2C32235FF" modified="2015-07-22" version="1">MLVVGGGPAGLATAAALRAAGVRAVVLERGARVGDSWRRHYDGLRLHTPRRMSGLPGMPLPRRYGRWVGRDQLAHYLEEYAEAHQLEIVYNVEAARVDRAGPGSASGSGWTVAATGGRVLDGRRVVVATGYCHTPYVPDWPGRDTYRGELLHAAYYRNPAPYEGKDVLVVGGGNTGAEIAVELAAGGAKRVRLAVRTLPHVVRRPAAGWCAVAGRRLSGALPARTVDRLAGRVSRIGLPDLGAYGLPRPASGLYTRLREGAVPVVDTGLVAAVRDRRVLPVPAVAALDGDGVILADGDRAEPDTVIAATGWRRGLEELVGHLGVLDPRGLPRAGGRRSPEGARGLHFVGFTGPASGSLREIGAEAEELARKVAKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6U1</accession>
    <name>A0A0F7N6U1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AA958_10200</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015879.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH82537">
        <property type="protein sequence ID" value="AKH82537"/>
        <property type="gene ID" value="AA958_10200"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_10200"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2148"/>
    <dbReference type="OrthoDB" id="149255at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004869">
        <property type="entry name" value="MMPL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03176">
        <property type="entry name" value="MMPL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="223"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="317"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="344"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="406"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="551"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="578"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="619"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="664"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="695"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="8">
        <location>
            <begin position="242"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="742"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="750"/>
            <end position="764"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH82537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="771" mass="79789" checksum="124A9C0CED93B7D8" modified="2015-07-22" version="1">MAEGTNGGTAGVSRWTRFVTARPRLSLLLALVFTALAVVTGSGVADRMSGGGWQDPASESAYAADALDAQFPGARPNLLLLVDSGRPDGVDDPAVVAEAERLAGRLAAVDSVEGVTSYWAAARTAGQAEAGPAGGAAGAEEARGAAAAAAGLRSEDGSEALIAARITGDETRNSEVFDELAPDFRGEHGPVEVRLGGQAAIYDELQGTIQEDLLRAEIIALPVTLLLLIVVFGSAVAALLPLAVGIIAILGTNAVLRGITEFADVSVFAQNLTTALGLGLAIDYALFIVRRYREELAAGADPLGAVGTTLRTAGRTVLFSALTVAVSLSAMLLFPQYFLRSFAYAGIAVVLLAAVAALTVLPAALVLLGPRVNGWRILPKRGGGVPGGAESGRGWARLAKVVMRRAPVFAVLTTGGLMLLGLPFLGVQFGTADDRQLPGSAESHVVQEHIRDGFPGTPGGTIEIYVEGDPAATELAAYQERIAALDGVERVDGSAMNAGAGYLTVTAEGEAVEASSQDLVRDIRDLGPPFEASVAGSAADLVDAKDSIQSVLPWAALMIVLATLILLFLLTGSVLIPFVAVVLNALSLTAMFGAIVWVFQDGNLSGVLNFTATGDIETTLPVLMFCVAFGLSMDYGVFLLSRIKEEYDRTGDRDGAVVFGLRRTGGLITAAAVILAVVMFAIGTSRVTNTKMLGIGLALAVLMDAMVVRGLLVPAVLKLTGAATWWAPGPLRRFHARVERSGFGEGGPRAAGQEEERPADKSDDLTPIGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N6Y8</accession>
    <name>A0A0F7N6Y8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_13935</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016481.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH83153">
        <property type="protein sequence ID" value="AKH83153"/>
        <property type="gene ID" value="AA958_13935"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_13935"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2933"/>
    <dbReference type="OrthoDB" id="1437290at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="14"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH83153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="213" mass="22037" checksum="5A7D5DAABF34C1A8" modified="2015-07-22" version="1">MPYRRTPAVQARMDGRRDAVLGAARALLADEGYAGCTVAAVAARARIATGSVYRHFPSKSVLAVELFRSVVTAEVDAVSAAARRPEDPAEGVAAAVETFARRALASPRLAYALLVEPVDTAVEAERLVFRRAFRDVFAARIAEGTGSGRLPRQDPLLTAAGLVGACAEALIGPLSGAAGSAATGRTEGPGPHTPAHLVAFTLRALGVPHADHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N779</accession>
    <name>A0A0F7N779_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminoglycoside phosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_14565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016564.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_14565"/>
    <dbReference type="EnsemblBacteria" id="AKH83249">
        <property type="protein sequence ID" value="AKH83249"/>
        <property type="gene ID" value="AA958_14565"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_14565"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3068"/>
    <dbReference type="OrthoDB" id="1457558at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="36"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="328" mass="36564" checksum="C8F8E8F0CC404444" modified="2015-07-22" version="1">MESITKNRQSPDALRAMVERAYGADRVPVGDGWAVELGHGWFNVAYRIRLRDGAEVVVKIAPSPQVEVMTYERGAMAAELRMLDLLRTHTTVPVPAVDFADLSRELCDADYFFMPYIDGDNLGVIAKELPAAARDSLMEQVGAANREINSLRGDAFGPLAGPGEPSWRRVFTGMVEDVLADGERRGVDLGWGYDTVRAVVDAHAGSLDEVTEPRLVEWDLWAGNVMVRDGKIAGIIDHERAFYGDPLIESGFAGTQMAAFGHPVPFMRGYGHPELTATQQVRRRLYCLHLMLIMVIETVYRGHSDSKQYDWARIRLDEAMALFGHTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N780</accession>
    <name>A0A0F7N780_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_10995</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016005.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_10995"/>
    <dbReference type="EnsemblBacteria" id="AKH82667">
        <property type="protein sequence ID" value="AKH82667"/>
        <property type="gene ID" value="AA958_10995"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_10995"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2315"/>
    <dbReference type="OrthoDB" id="139229at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006775">
        <property type="entry name" value="GH116_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024462">
        <property type="entry name" value="GH116_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04685">
        <property type="entry name" value="DUF608"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12215">
        <property type="entry name" value="Glyco_hydr_116N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydr_116N" evidence="3">
        <location>
            <begin position="90"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="DUF608" evidence="2">
        <location>
            <begin position="672"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="473"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH82667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="1084" mass="116781" checksum="54F83304D8B18FC3" modified="2015-07-22" version="1">MTVDRAGRAGDHDCRPGTGCCPPHGSAVPDGLNRRGFVALGAAAAVALGLPPRSAVAVPADKGLGDGWFKELRRRGEATAYRGDALENVGMPVGGIAAGQVYLAGDGRLWLWEVDNPDSFPYGGADWQGIHYAEPLPVTAPFATGFALRWASAASGGTASLDGDGFADVVFRGRYPLGTVTYADPGVPLAVTLDAYSPFIPTSVDDSSLPVTVLDYTLRNTANRPLTAELLGFAENPVCLRSRTAQPVTLTAAPFEGAATGVQFGARAGTSPEPPRGEIVFEDWERTDYSRWTATGTAFGPGPVTEAECPDYFKRFGDLGVSGTRFVTSHHFRAGGDAAAADGHTGKLVSEPFIIERRYIAVAVGGGSQAGTACVNVVVDGETVASFTGRNAEPMSPRAYDVSAHEGKRATIEIVDESTGGWGHVNVDRIRFTDTPVAEQPLGELTDHGTFALAAAHPAARVRPSVADWSTPDALFDSADAPAETDGGRARPTGGQAGTVTVPVRLAPGETARIRFTLAWHFDRVDRQLFGYLTGAGSLRRHYGTRFADARAAAAHTAARGDELAAATREFVRTWYEDATLPHWFLERTLAPASTLATSTVHRFQDGRFYAWEGLYCCDGTCTHVWNYAQSAARLFPALERDTRERVDLGLAFHEDTGAVDYRGEAARHVAHDGQCGNVLRTYREHLMAPDSAFLTRVWPRVKKATAYLIRADALDGRPADGVLEGEQYHTLDASWYGEIPWISGLYVAALHAAAAMADEMADAAFAAECRELAARGTKELEARMWNERYGYFEHLVDPAHADAINSNRGCHIDQMYGETYAFQLGLPRVFPGDKARTALANLYRHNFLPDAQSYKDVSGIPGGRIYSTEGEAGTVMCTWPFGGSDTAPGGGEPFAIGYFNEVWTGQEYQFAAHLMHEGMTDEALAVTRAVHDRHSAEKRNPYNEIECSDHYARAMMSHAVYLAATGFDYHGPHGRLGFAPRLEEGQDFAAAFVTAEGWGLYRQRRRGHTLTARAELRYGTLRLTSLAAPARAGARATAEAIGRDGRRRRVAVRGASAGKGRVAAEFAEAVTLQAGETLEVTYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7M8</accession>
    <name>A0A0F7N7M8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Deferrochelatase</fullName>
            <ecNumber evidence="6">1.11.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Peroxidase EfeB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AA958_15715</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in the recovery of exogenous heme iron. Extracts iron from heme while preserving the protoporphyrin ring intact.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>2 H(+) + heme b = Fe(2+) + protoporphyrin IX</text>
            <dbReference type="Rhea" id="RHEA:22584"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:57306"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="4.99.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:22585"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
        <text evidence="6">Binds 1 heme b (iron(II)-protoporphyrin IX) group non-covalently per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the DyP-type peroxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.-" evidence="6"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016725.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_15715"/>
    <dbReference type="EnsemblBacteria" id="AKH83413">
        <property type="protein sequence ID" value="AKH83413"/>
        <property type="gene ID" value="AA958_15715"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_15715"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3312"/>
    <dbReference type="OrthoDB" id="837319at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033212">
        <property type="term" value="P:iron import into cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
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        <property type="entry name" value="Dyp_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006313">
        <property type="entry name" value="EfeB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04261">
        <property type="entry name" value="Dyp_perox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01413">
        <property type="entry name" value="Dyp_perox_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01412">
        <property type="entry name" value="tat_substr_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51404">
        <property type="entry name" value="DYP_PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1 6 8" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014487516" description="Deferrochelatase" evidence="6">
        <location>
            <begin position="51"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00033706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH83413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="431" mass="44969" checksum="7801B9B3DCCD1CEC" modified="2015-07-22" version="1">MSSTRSTRTAPESETAEAPRHPVSRRRLVGAAGAAGAAGLLAGGASGAAAAEALRDAPPAPLTSIGATGVPFHGTHQAGITTPLQAAGHFAAFDLAPGAGRKEAAALLKRWSATARELSEGKGAAAGTGSALDAGPAALTVTFGFGRTFFDRTGLTGRRPDGLAPLPPFSADALDARRSDGDLWLQIGADDALVAFDALRTLQRRAGDAAVLRWQMSGFNRTPGATDRPRTARNLMGQVDGTNNPKPEDPDFDEHVFVPASAGGGQEWLAGGSYAVFRRIRMLLDTWDHLSLERQERVIGRRKSDGAPLSGGEETTPVDMNKQLADGSLAIAGDAHVRVAAPESNGGATMLRRSFSYHDGYLDTKDGPVPDAGLLFVAWQADPLKGFVPVQRKLDRGDGLSRFLRHEASGLFAVPGGAAEGEYVGQRLLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N7Y8</accession>
    <name>A0A0F7N7Y8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_16380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016829.1">
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_16380"/>
    <dbReference type="EnsemblBacteria" id="AKH83524">
        <property type="protein sequence ID" value="AKH83524"/>
        <property type="gene ID" value="AA958_16380"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_16380"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3448"/>
    <dbReference type="OrthoDB" id="1313493at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="294" mass="32712" checksum="A76358224306729B" modified="2015-07-22" version="1">MTEPAEPDEQTPPDDEHARADGTPGGERAEDADGGEDTGAERLERAVRAAEQALIEFEVAVETFRIEVDNFSRLHHQRLGPMYSRLDELDALIAEARAERTGDPEDKRRADEARALVMPMPGVEELFGGWLDSDGLSPEAADMLTGRPVSPPPRVRPSEEARRLYRELARMAHPDLAQDEHESDRRSAFIARVNTAYASGDVEVLTALKAEWQAGPAPEEHRRSRAEELYERLEWLAQRKELLVSVATQLEEGAIGQMLKLAPDDPDRLLEEIAEELLARVSEKEAALAELARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N809</accession>
    <name>A0A0F7N809_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Plasmid stabilization protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_12610</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016267.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_12610"/>
    <dbReference type="EnsemblBacteria" id="AKH82932">
        <property type="protein sequence ID" value="AKH82932"/>
        <property type="gene ID" value="AA958_12610"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_12610"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2649"/>
    <dbReference type="OrthoDB" id="1177619at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007742">
        <property type="entry name" value="NosD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022441">
        <property type="entry name" value="Para_beta_helix_rpt-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05048">
        <property type="entry name" value="NosD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03804">
        <property type="entry name" value="para_beta_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519343" evidence="2">
        <location>
            <begin position="27"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="NosD" evidence="3">
        <location>
            <begin position="166"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="366"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH82932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="447" mass="45568" checksum="9B55AD99D5E3C1CB" modified="2015-07-22" version="1">MSRSARRVMAALLGALTFLAGCGSGGDDGGPDKGRRPDGARVTIRVPGDAPTISAGVALARPGDLVLVAPGVYREAVKLGTPRVTLRGESRAGVVIDGELRRPNGVVVTAPGVAVENLTVRRNTQNGVLVTGSAAAVDGLPGSGGYDTGEEPVRLLKSFLVSHVTATRNGLYGIYAFSAQNGAIEHSYASGGADSGIYVGQCKPCRIVVRDNVSELNAVGYEGTNASGQMYVVGNRLAGNRVGLTTSSDHQEKLLPQRDAVVAGNLIAENQHPRTPEQADGGWGIGIGVDGGSGNRFLRNRISGNTHAGLVITATADLTADRNRITDNTFTGNGIDVGATFPTATRGQGNCLRGNALRKTVPAGLTDTASCPVPATSPTPAGSWPSEKGPAGIPFTEVAAPGPQPEFPRAATAGATAVPDVPALPDVADTALPPESLLAGRARVRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N872</accession>
    <name>A0A0F7N872_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Robl_LC7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_16990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016928.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_16990"/>
    <dbReference type="EnsemblBacteria" id="AKH83624">
        <property type="protein sequence ID" value="AKH83624"/>
        <property type="gene ID" value="AA958_16990"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_16990"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3573"/>
    <dbReference type="OrthoDB" id="1723871at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004942">
        <property type="entry name" value="Roadblock/LAMTOR2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03259">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00960">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Robl_LC7" evidence="1">
        <location>
            <begin position="6"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="134" mass="13671" checksum="6A7499045D62612C" modified="2015-07-22" version="1">MSESLDWLLANFVQQVASARSAVVASTDGVRMHAHDLDTAAADRLAAVATGLFSLGAGIGTDTVRGVRQVLVEHEDVVLCVMAAGPGAVLAVLAEPDADLGVIGYEMGQLVKRVPTHLTSPARTAAAAAPGSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8E4</accession>
    <name>A0A0F7N8E4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransf_11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_17505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_17505"/>
    <dbReference type="EnsemblBacteria" id="AKH83704">
        <property type="protein sequence ID" value="AKH83704"/>
        <property type="gene ID" value="AA958_17505"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_17505"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3684"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="48"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="259" mass="27733" checksum="817D4EDA6E388DCB" modified="2015-07-22" version="1">MDTEEWQRYVTAYHDARPGITERIFALAEASPYAWLAEPLHAGPGPVLDLACGSAPTRELLPGTGWIGVDSSRGELGEAARRGRAPLVRANADALPVRTGSIGVVCAAMCLPVVTPLPQVLGEVRRVLRPGGRLAALVPASSGLSVAGAAGWVRVMGALRAVHQPWPNPDARDGLAGLLRRAGFAVRSDERHVFTLAIETPRAAALLAESLYLPDLTARRAQFAKRSLARWARPGRRLQLPLRRVVAEHPAPYPGREGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N8H8</accession>
    <name>A0A0F7N8H8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_17710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017041.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_17710"/>
    <dbReference type="EnsemblBacteria" id="AKH83739">
        <property type="protein sequence ID" value="AKH83739"/>
        <property type="gene ID" value="AA958_17710"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_17710"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3729"/>
    <dbReference type="OrthoDB" id="1462898at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="1">
        <location>
            <begin position="31"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="396" mass="42415" checksum="258AF2A391982E73" modified="2015-07-22" version="1">MGRPPLSSRLTPFVTTIFAEMSALAVRTGSINLGQGFPDTDGPAEVAEAAVRAIREGRGNQYPPGPGIPELRHAVAEHQRRWYGLEWDPESEVLVTAGATEAVAAALLALLEPGDEVIALEPYYDSYAACIAMAGARRVPVTLRPGAGAGAGAPAYRLDLDELRAAVTPATRLILLNSPHNPTGTVLDRTELEAVAALARERDLLVVTDEVYEHLVFDGAHIPLATLPGMRERTVSISSAGKSYSFTGWKVGWVTAPAPLVAAVRTAKQYLTYVSAGPFQYAVAEALALPDAYLTGLRADLLRKRDLLAAGLTEAGLRVFRPSGTYFITADITPLGEKDGVAYCMSLPERCGVVAVPTQVFYDDPDAGRSIVRFAFCKKDEVLKEAVRRLKEGRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N902</accession>
    <name>A0A0F7N902_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">IclR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_22455</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017761.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_22455"/>
    <dbReference type="EnsemblBacteria" id="AKH84501">
        <property type="protein sequence ID" value="AKH84501"/>
        <property type="gene ID" value="AA958_22455"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_22455"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4726"/>
    <dbReference type="OrthoDB" id="370329at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
            <begin position="2"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="4">
        <location>
            <begin position="62"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH84501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="249" mass="27196" checksum="94AED1E2534A644D" modified="2015-07-22" version="1">MSQSVGRALAILPMLAEGPAGLEQVATRLGVHKTTAMRLLRTLHEHGLVYRQDDQRYRLGARLFALAQAAAESLDVREIAHPHLVKLGEQTGHTVHLAVYEDREVMYIDKVDSRYPVRMYSRIGRPVAITVAAVAKLLLADLPDPERRAVAERLEYPMYTPRSTPDAQALLTELAAVREQGWATDFGGHEESINCIGAPIRGADGRTVAACSLSAPNVVVTADELMTLLPQLRRTAAAISDDYSGRVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N922</accession>
    <name>A0A0F7N922_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Transcriptional regulator WhiB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">whiB</name>
        <name evidence="13" type="ORF">AA958_14500</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="11">Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="11">The Fe-S cluster can be nitrosylated by nitric oxide (NO).</text>
    </comment>
    <comment type="PTM">
        <text evidence="11">Upon Fe-S cluster removal intramolecular disulfide bonds are formed.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the WhiB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016557.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_14500"/>
    <dbReference type="EnsemblBacteria" id="AKH83242">
        <property type="protein sequence ID" value="AKH83242"/>
        <property type="gene ID" value="AA958_14500"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_14500"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3053"/>
    <dbReference type="OrthoDB" id="1929976at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035731">
        <property type="term" value="F:dinitrosyl-iron complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01479">
        <property type="entry name" value="WhiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034768">
        <property type="entry name" value="4FE4S_WBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003482">
        <property type="entry name" value="Whib"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38839">
        <property type="entry name" value="PTHR38839"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02467">
        <property type="entry name" value="Whib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51674">
        <property type="entry name" value="4FE4S_WBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 11" id="KW-0408">Iron</keyword>
    <keyword evidence="6 11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 11" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="4Fe-4S Wbl-type" evidence="12">
        <location>
            <begin position="12"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AKH83242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="118" mass="13085" checksum="FD8F9DFA067F7791" modified="2015-07-22" version="1">MSWVTDWSAQAACRTADPDELFVQGAAQNRAKAVCTGCPVRTECLADALDNRVEFGVWGGMTERERRALLRRRPTVTSWRRLLETAREEYESAGTPLHESALHEDALRAAEELPVAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N987</accession>
    <name>A0A0F7N987_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_19945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017368.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH84078">
        <property type="protein sequence ID" value="AKH84078"/>
        <property type="gene ID" value="AA958_19945"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_19945"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4202"/>
    <dbReference type="OrthoDB" id="2180496at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519334" evidence="1">
        <location>
            <begin position="37"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="122" mass="12551" checksum="95B3C18185E59188" modified="2015-07-22" version="1">MRRTRLSATLATLALTATLAGTATATAAPPAADAPAAPSCVKGYVCVQPLNGFTIRVPEGSRQDFDPPLAIASVVNETSTGYCLTGTYNRGIAPGSVFEPRAAYSLRSLTPSPNGYCLATDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9Q9</accession>
    <name>A0A0F7N9Q9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH marR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_27065</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018525.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_27065"/>
    <dbReference type="EnsemblBacteria" id="AKH85290">
        <property type="protein sequence ID" value="AKH85290"/>
        <property type="gene ID" value="AA958_27065"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_27065"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5698"/>
    <dbReference type="OrthoDB" id="1744037at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023187">
        <property type="entry name" value="Tscrpt_reg_MarR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01117">
        <property type="entry name" value="HTH_MARR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="2">
        <location>
            <begin position="14"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH85290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="181" mass="19498" checksum="1445EE553C093BC4" modified="2015-07-22" version="1">MAEGADHLVDADDIDGVTRAVLTTSRVLVAIAARSLAAVEGTVTLAQFRMLVVLSTHGPVKLVALAQQLEVNPSTAMRMADRLIATGLISREVNPTDRRETVLRVTPPGRRLVNEVTARRRDEIAAIVARMAPPQREALITALTAFTDAGGEREAESPDQPRYPLGWAEPVPPGGADHDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N9Z4</accession>
    <name>A0A0F7N9Z4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phenylacetate-CoA oxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_16410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016832.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_16410"/>
    <dbReference type="EnsemblBacteria" id="AKH83527">
        <property type="protein sequence ID" value="AKH83527"/>
        <property type="gene ID" value="AA958_16410"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_16410"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3454"/>
    <dbReference type="OrthoDB" id="623539at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097266">
        <property type="term" value="F:phenylacetyl-CoA 1,2-epoxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010124">
        <property type="term" value="P:phenylacetate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011881">
        <property type="entry name" value="PaaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007814">
        <property type="entry name" value="PaaA_PaaC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05138">
        <property type="entry name" value="PaaA_PaaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02156">
        <property type="entry name" value="PA_CoA_Oxy1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="344" mass="38334" checksum="972C90CC02D0EB06" modified="2015-07-22" version="1">MPETISERGRGPGAEPGPRSRMGTGTAEAAPQATAAFEAKIAADERIEPRDWMPDAYRATLVRQIAQHAHSEIIGMQPEANWLTRAPSLRRKAILLAKVQDEAGHGLYLYSAAETLGTGRDELLDKLHAGRQKYSSIFNYPTLTWADVGAIGWLVDGAAIINQVPLCRCSYGPYARAMVRICKEESFHQRQGYELLHTLAHGTPGQRAMAQDAVDRWWWPSLMMFGPPDDESAHSAQSMAWKIKRHSNDELRQRFVDICVPQAEVLGLTLPDPDLRWNEERGQHDFGAIDWTEFKEVLRGNGPCNEQRTGRRRQAHEDGAWVRDAAAAYAAKRARDAESAEAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NA23</accession>
    <name>A0A0F7NA23_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Response regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_24765</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018133.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_24765"/>
    <dbReference type="EnsemblBacteria" id="AKH84881">
        <property type="protein sequence ID" value="AKH84881"/>
        <property type="gene ID" value="AA958_24765"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_24765"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5222"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="7"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH84881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="150" mass="15786" checksum="0C9948EC4736EB81" modified="2015-07-22" version="1">MPGLSGRVLVVDDNKVIRQLIRVNLELEGFEVVTAADGAECLEAVHRVRPDVVTLDIVMPRLDGLRTAARLRADPRTRGLPIAVVSGCSELEAEAGRAAGVDAFVAKPFEPVDLVRVVRRLAARRASQRVGGGVAGDAADDAEPAGSPVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAM0</accession>
    <name>A0A0F7NAM0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AA958_17755</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017049.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH83747">
        <property type="protein sequence ID" value="AKH83747"/>
        <property type="gene ID" value="AA958_17755"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_17755"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3738"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025565">
        <property type="entry name" value="DUF4328"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14219">
        <property type="entry name" value="DUF4328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="396"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="445"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="535"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="566"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="15"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="307"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AKH83747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="606" mass="65101" checksum="D315251056F60DCC" modified="2015-07-22" version="1">MDSLGPDDPRRVGSYQLLGRLGEGGMGRVYLARSERGRTAAVKLVKAELAREPEFRRRFTQEITAARRVGGEWTAPVLDADTHAATPWVATGYVAGPSLHEVVAKDHGPLPDASVRALAGGLARALQAIHAAGLVHRDLKPSNILVTIDGPRVIDFGIARALDSVTAAGDGLTRTGAVIGSPGFMSPEQVRGERVTAASDVFCLGTVLAFAATGRMPFGTEDSGAHALMFRIAAEEPELSGIEGELRTVIERCLAKEPDARPQVAELVALTEEAARLKPWLPGALLELLARRAVELLDAETPQAAGGMTGTAGAAPAYGPPLTGAGPGPYGHTGMQPQHHQPYGAPPHAQQHRPAAYGTAPTAHPPPYRTPPPYGQTGWQTPHPPLPLRPRAVRPVATALQVLLGIYAAFVCLQVIQEINLLVLLGEDGADTWYMAEDLDRMENFTAGNVLLFMVCAVLWSVWFYRLRTNSEAFAPGQVRYSTGLAVGSWFIPVAQFWFPLQIANDIFRISSPFPHHARPPAGYGPRPVTYGKGVLNFWWATWVATMVLALVTAEDWEVGSSIDSAIQIVLLDLLFSFVLIVTSIMALLAVQQLTTLQDQRLKGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAR2</accession>
    <name>A0A0F7NAR2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_22720</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017806.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH84549">
        <property type="protein sequence ID" value="AKH84549"/>
        <property type="gene ID" value="AA958_22720"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_22720"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4778"/>
    <dbReference type="OrthoDB" id="2064132at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019239">
        <property type="entry name" value="VapB_antitoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09957">
        <property type="entry name" value="VapB_antitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="26"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH84549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="83" mass="8999" checksum="DBB173CA4DA07790" modified="2015-07-22" version="1">MGKTLIEIDEDALAVAQDAFGTKTKKDTVNRALREVSDRVKRHEARMAAERLAAEALDLDALTDKTAYRPGPATDDSKQGQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NAU0</accession>
    <name>A0A0F7NAU0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_18245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH83827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH83827">
        <property type="protein sequence ID" value="AKH83827"/>
        <property type="gene ID" value="AA958_18245"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_18245"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3836"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH83827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="56" mass="5855" checksum="7BA674B70C8CBCDA" modified="2015-07-22" version="1">MDYLSALLPSTVMAIAFTVMIVTIVKNQGGPNKAKEDAAVDAAFAQAEAVKQKSAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NB21</accession>
    <name>A0A0F7NB21_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_23295</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047017900.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_23295"/>
    <dbReference type="EnsemblBacteria" id="AKH84644">
        <property type="protein sequence ID" value="AKH84644"/>
        <property type="gene ID" value="AA958_23295"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_23295"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4911"/>
    <dbReference type="OrthoDB" id="741829at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="865"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="619"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="877"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="413"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="452"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="490"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="532"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH84644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="957" mass="94061" checksum="DE1D0827941E8F71" modified="2015-07-22" version="1">MDQGKPSWWRQEPGEPPREAESDTAGPPTDSDAYAQPAPPPADAGPPPGYDPEVDQLRRVREALREWRDGEDDYHRDRSRAAAGSAADGGPADASVPAPGGAETPADGVAVPAESGPGGSSREPVRAADADSAVEQDAGGQDVTAPGGRPAPESATPAGTGADAASVPERTEAAGVGGPGGTPRADEDAVRSADASAGSAVTAADLPGPRVAETGGPAAADTGALPTRTRAGDTPGPAAADRAPGTEGPGTEPRALPARTATPAAEGPAAEPSPPGPGQDQDGAAADAGSPEERPWEVGVRPYPGAAEAGAEGSPGGRGIPAAVSAVAGARAGRAALPQQDERATTPGTPAEPADAPQNAAEPPRPAVPPAGDRAAASGRESTAKTPGDAAARTDAPEGSGDAGAFGPPPSDESHREVADRPPAAGPREGVEDDDTTQLAVISESGAPPSGDLPGPRRPAADAPAPRRPAPADTRHPAPQGAHPAHPGAQGAPGPQPRPRAPYGPGAQAPVPGATPAGGAPPGEYGPQGAGRPPGAHPPAASGAPGPGGPAPYGAHPQGAPQGGQWQRYDPWAPAHAAHAPERRKGRLATLVGALVIALVAGGIGGALGSYIERNGTPGQLELDQSSAADDGGKRPPGSVAGIARSALPGVVTLRVSGVAEQSTGTGFVLDKRGHILTNNHVVQPADEGGDITVTFSGGESKSAEVVGGDAGYDLAVVRVKGVSGLKPLPLGNSRSVAVGDPVVAIGAPYDLPNTVTSGIISAKERPITAGGEQGDGSDISYVNALQTDAPINPGNSGGPLLDLEGRVIGINSAIRAADNGSGEPQTEQGGSIGLGFAIPVNKGADVAEELINTGKATHPVIGVTLNMQYTGDGAQVGTSAEEGGTEPVTPGGPADSAGIEPGDVITGVDGEAVHNGEELIVKIRSRSPGEDLSLTVERDGEELTVDVTLGEGDSTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NB73</accession>
    <name>A0A0F7NB73_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Selenide, water dikinase</fullName>
            <ecNumber evidence="5">2.7.9.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Selenium donor protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Selenophosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">selD</name>
        <name evidence="8" type="ORF">AA958_29995</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Synthesizes selenophosphate from selenide and ATP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + H2O + hydrogenselenide = AMP + 2 H(+) + phosphate + selenophosphate</text>
            <dbReference type="Rhea" id="RHEA:18737"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16144"/>
            <dbReference type="ChEBI" id="CHEBI:29317"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.9.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="5">Binds 1 Mg(2+) ion per monomer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the selenophosphate synthase 1 family. Class I subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.9.3" evidence="5"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018983.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_29995"/>
    <dbReference type="EnsemblBacteria" id="AKH85755">
        <property type="protein sequence ID" value="AKH85755"/>
        <property type="gene ID" value="AA958_29995"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_29995"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6334"/>
    <dbReference type="OrthoDB" id="882590at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004756">
        <property type="term" value="F:selenide, water dikinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016260">
        <property type="term" value="P:selenocysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02195">
        <property type="entry name" value="SelD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00625">
        <property type="entry name" value="SelD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023061">
        <property type="entry name" value="SelD_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004536">
        <property type="entry name" value="SPS/SelD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10256">
        <property type="entry name" value="PTHR10256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036407">
        <property type="entry name" value="Selenphspht_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00476">
        <property type="entry name" value="selD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0711">Selenium</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AIRS" evidence="6">
        <location>
            <begin position="53"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="7">
        <location>
            <begin position="172"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="14"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="51"/>
            <end position="53"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="142"/>
            <end position="144"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="5">
        <location>
            <position position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH85755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="334" mass="33812" checksum="1708C096BFF4C26E" modified="2015-07-22" version="1">MTVRLTQYAGGGGCACKIPPGELDTLVSSLSLTGSRPEDPAAELLVGLEGGGDDAAVVRLDDERAIVTTADFFTPVVDDAYDWGRIAAANALSDVYAMGGTPWAAVNLLAWPGDTLPMELAAEVLRGGRDVAHAAGCQVSGGHSVTDPEPKYGMSVVGMVHPGRMLRLDAAEPGRALTLTKPLGSGVLNARHKATGEVFPEAVAVMAALNRDAASAAVAAGIRAGTDVTGFGLLGHAYKLARASGVTLAIHAAAVPLLAEAGPAAADGFVSGGTRRNLAWVGPWVDFGALPEVERLLLADAQTSGGLLLAGEVPGHPVIGEVLPAGESPVVVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBG1</accession>
    <name>A0A0F7NBG1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sulfate ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_28100</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018690.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_28100"/>
    <dbReference type="EnsemblBacteria" id="AKH85456">
        <property type="protein sequence ID" value="AKH85456"/>
        <property type="gene ID" value="AA958_28100"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_28100"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5922"/>
    <dbReference type="OrthoDB" id="1531811at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="271"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="108"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH85456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="310" mass="32380" checksum="A60D575D458B7A72" modified="2015-07-22" version="1">MASTDTTGSTGTSGAKSGAKSGEDSAARLAGLEAGLDALDTRTASRTPLRQVLLQKVLPPIIAVALVVAVWQLLYVLEVKPDYQLPGPGQVWDALADQWYEGTLFDVIWTSLSRGVLGFLIAIAIGTPLGLIVAKVPFVRAAIGPVLTGLQSLPSVAWVPAAIIWFGLTPSMIYAVVLLGAVPSIANGLVAGIGQIPPLYLRAGQVIGAAGLHGVRHVLLPAALPGYLAGLKQGWAFSWRSLMAAEIIATSPDLGVGLGQLLETGRGYQDMAIVLNAILLILIVGVAIELLVFGPLERRVLRNRGLLVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NBJ2</accession>
    <name>A0A0F7NBJ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_28480</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018760.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_28480"/>
    <dbReference type="EnsemblBacteria" id="AKH85526">
        <property type="protein sequence ID" value="AKH85526"/>
        <property type="gene ID" value="AA958_28480"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_28480"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6001"/>
    <dbReference type="OrthoDB" id="1465613at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="130"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH85526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="335" mass="34668" checksum="8EB2AD0FCEF14788" modified="2015-07-22" version="1">MRIGLLGTGRIGAFHAAALRRHPDVTSLVVTDADPRRAAEVAARTDAEAVATPAGALAAGVDAVVIAAATAAHAELLGAAARAGLPVFCEKPIAVDLAGTRAALAEVAAAGIVLQMGFMRRFDAGYAAAREAVRGGRLGRLHTVRTATSDPAPPPAAYLPLSGGLYRDCVIHDVDALRWVTGREVTEVYAAGSDAGPAMFREAGDVDTAAALLTLDDGTLATATATRVNGAGYDVRMELAGERDQIAVGLDERTPLTSVEPGTPARAGKPWQGFLERFGPAYEAELAAFVRVVRGELANPCDGAEALAALHVVEACELSRRERRPVRVAEIADAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NC54</accession>
    <name>A0A0F7NC54_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_30280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_30280"/>
    <dbReference type="EnsemblBacteria" id="AKH85796">
        <property type="protein sequence ID" value="AKH85796"/>
        <property type="gene ID" value="AA958_30280"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_30280"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6397"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="2">
        <location>
            <begin position="23"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="509"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH85796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="542" mass="56829" checksum="ECD4326AA287C259" modified="2015-07-22" version="1">MSAQDGVPGVRAGGPSRTTRLDAQVIIVGAGPVGLMLAGELSLRGVRVVVVEQRHGPTTESRASTLHARTMEIFDSRGLLPDVGGPPNATRGHFGGIPLDLTLPGAYPGQWKVPQAKTESVLEEWALSLGADIHCGTRLRVLGVTQEGDSVEAEAVGRDGEVVRLRAAYLVACDGQDSTVRRLTSAPFPGHGAARELLRADVAGIDVPDRRFERLPRGLAIAARREDGVTRVMVHEFGAPVRASGKPDFAGFCATWRRVTGEDISGGTPLWVNSFHDANRQLASYRQGRILYAGDAAHQQLPIGGQALNLGVQDAFNLGWKLAATVRGRAPEGLLDSYHTERHAVGRAVLGNIRAQALLLLGGHDNDPLRTVLTELIGHEAVRTTLAGAVSGLGIRYDVGGPPHPLLGARLPHARLLVAGAPRTTAELLRSGRGLLLGLGGAPPAGADGWADRVDVVTAEPEPPRADGAAGPLDGTGALLVRPDGYVAWAGDRRGDGLAEALRRWFGTPGEPHGRATAATAAGAARRTERTHTPAPVHHGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCA2</accession>
    <name>A0A0F7NCA2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_32130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019328.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_32130"/>
    <dbReference type="EnsemblBacteria" id="AKH86100">
        <property type="protein sequence ID" value="AKH86100"/>
        <property type="gene ID" value="AA958_32130"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_32130"/>
    <dbReference type="OrthoDB" id="1832160at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HATPase_c" evidence="2">
        <location>
            <begin position="29"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH86100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="176" mass="18603" checksum="367101427A894A8E" modified="2015-07-22" version="1">MSDGGSLRPESGQVVPAAYEGTWKFDAPALDSSVPQSRHAVRDLLVRRRVPIGDDLLQGVLLIVSELVTNAVRHAGVLSPEIGVELSVGAGWVRVAVRDQHPYRPRALQADDEETGGRGLLLVKVITSEAGGACDVQHTVDGGKVIWASLPLAGVTSPRTAPSAPGWPAWPRRAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCP2</accession>
    <name>A0A0F7NCP2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_33090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S58 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019482.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_33090"/>
    <dbReference type="EnsemblBacteria" id="AKH86255">
        <property type="protein sequence ID" value="AKH86255"/>
        <property type="gene ID" value="AA958_33090"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_33090"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6990"/>
    <dbReference type="OrthoDB" id="2000083at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016117">
        <property type="entry name" value="ArgJ-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005321">
        <property type="entry name" value="Peptidase_S58_DmpA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36512">
        <property type="entry name" value="PTHR36512"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03576">
        <property type="entry name" value="Peptidase_S58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56266">
        <property type="entry name" value="SSF56266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="344" mass="34357" checksum="5C597F5E11ACF2B2" modified="2015-07-22" version="1">MDELAAPAGRRARDLGLVAGRFPAGPYGAITDVPGVRVGHVTLREPPLLHSGVTAIVPGDVRPGAPLPAGVFTGNGYGKLIGSTQLAELGALETPVLLTSTLSAFRAADALVGWMLERPACADVTSLNPVVGECNDGVLSDIRARPVREEHVRAALDAAAGGPVAEGCTGAGTGVAALGFKAGVGTASRLVETGGHSACVGVLVQANFGGTLRVLGRTVTPADLGVPGPGAAPGAGSCMVVAATDAPLDARQLTRVARRAVFALARTGAAYGHGSGDYAIAFGVRPGGPPPADAALDPLFEAVMDAVEEAVLNSLLAATTTTGPAGRTRYALPAGRLLRLLGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NCW0</accession>
    <name>A0A0F7NCW0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dolichol-phosphate mannosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_33445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019544.1">
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_33445"/>
    <dbReference type="EnsemblBacteria" id="AKH86320">
        <property type="protein sequence ID" value="AKH86320"/>
        <property type="gene ID" value="AA958_33445"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_33445"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.7063"/>
    <dbReference type="OrthoDB" id="1064289at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004582">
        <property type="term" value="F:dolichyl-phosphate beta-D-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06442">
        <property type="entry name" value="DPM1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <begin position="17"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
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            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="255" mass="27848" checksum="658DE0C737B35C7D" modified="2015-07-22" version="1">MTDGVQGRYGPPGGILVIIPTYNEALNLESIVSRVRAAVPDADVLVVDDNSPDGTGKLADELSADDAHVHVLHRAGKEGLGAAYLAGFGWGLERDYGVLVEMDADGSHRPEELPRLLTALKGADMVLGSRWVPGGRVVNWPKSREFISRGGSAYSRLWLGLRIRDVTGGYRAFRRETLEGIGLANIASQGYCFQVDLARRVADGGYHVVEVPITFVERERGDSKMSKDIFAEAAWRVPAWGVRSRLGRILGRRHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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    </dbReference>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="AKH86231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="306" mass="34027" checksum="CE8088EA01B8F579" modified="2015-07-22" version="1">MTAPGPVDPVRTAALCLGPGALGWLHRNRARGTFADGATAELAEPDSVYKPLAELALAGSLVVRDDAFPAAERDAAAELLDFAWDQLRGGDLLYERQLRFPAMTDPLETYVHFHRAGYRHEPLQELLAHLTSLTSFREYEHVPNRRMAVANAARIIGVADRTDGPARTAATWLGATPEPWTMDWMTAYHVTHTVFHLTDWGAQPQALPPRLRDYLATWLPVWTDVWLEIEEWDLVAELLIVDACMPEPSFEPAAWRRLAAVQHEDGLLPRDGRTGTDDEDRRFEDHYHTAAVAAVAGSLVLSRLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDD7</accession>
    <name>A0A0F7NDD7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_02265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_02265"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.486"/>
    <dbReference type="Proteomes" id="UP000034283">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="167" mass="17627" checksum="5A43F426937344CC" modified="2015-07-22" version="1">MILTGAVVSGLLLVSGVWAVLGDSQRTLGVPVPGAELVHFASGHGYEPVRTVLRSRTDVADFAKRYPAAAKSARDPGGPGRRDFTTEALVAFAWRTGCTRAGSADLRSSEERGLFAEPADTTAYRKCAEPFDALAVFAVPREWAPHGVELSGEPPDPPGPTGAPEER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDG9</accession>
    <name>A0A0F7NDG9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_28170</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018703.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_28170"/>
    <dbReference type="EnsemblBacteria" id="AKH85469">
        <property type="protein sequence ID" value="AKH85469"/>
        <property type="gene ID" value="AA958_28170"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_28170"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5938"/>
    <dbReference type="OrthoDB" id="1421045at2"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017039">
        <property type="entry name" value="Virul_fac_BrkB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30213">
        <property type="entry name" value="PTHR30213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03631">
        <property type="entry name" value="Virul_fac_BrkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="286"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="351"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="351"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="379"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH85469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="419" mass="45367" checksum="488A6C367E4C4585" modified="2015-07-22" version="1">MSTCCHDSYGRQVGADRETGAELGGRGKPRGRLGRARALYQNLPKRRVAWLLLKDTVNSCMQYRVIGLAAEAAFFSLLSLPPLLLGLLGLLGYFDQWLIDVETIRHNIIDASDTVMTAKGVDEIVRPLLDDVTRGGRADLISFGFALALWSGSRAVNVFIDTITIMYGLEGHRGIVKTRLLAFGLYLVALVMGVVALPLMVAGPDAVVTLLPWSETAVRVLYWPVVVVLSVAFLTTLYHAAVPVRSPWREDLPGALVALGMWLLGSVLLRLYLVNAVEGPTIYGSLAAPVAVLLWFGVSAFAVLVGAAVNAAFDRVWPSVATATGRAETARAREEAAARLVAAASAERQARLRGLDGDASAEERAREPEPEWAEEEEEAAEESRRAAAKGRPAQPPERKGPAEWDDPADRVDGDRHEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDH1</accession>
    <name>A0A0F7NDH1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HpcH_HpaI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_33285</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019516.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_33285"/>
    <dbReference type="EnsemblBacteria" id="AKH86291">
        <property type="protein sequence ID" value="AKH86291"/>
        <property type="gene ID" value="AA958_33285"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_33285"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.7030"/>
    <dbReference type="OrthoDB" id="1107373at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005000">
        <property type="entry name" value="Aldolase/citrate-lyase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011206">
        <property type="entry name" value="Citrate_lyase_beta/mcl1/mcl2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03328">
        <property type="entry name" value="HpcH_HpaI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015582">
        <property type="entry name" value="Cit_lyase_B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HpcH_HpaI" evidence="6">
        <location>
            <begin position="29"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="136"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 4">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR015582-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR015582-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH86291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="357" mass="35917" checksum="531596A64F6B20A5" modified="2015-07-22" version="1">MSAPRPSAVAADPAGAGGPGDAGDTYLTWLYVPGDRPAVVAKALRSGADVVLVDLEDAVAPERKAYALAATAELLGEPRPGPVPVHVRVNALTGPLADVELRTLAPLPGLGGLRLPKTRGREEVLRVATAALAARAGAPAPVPAPGDGTPAAGPDDATGGAGPYPAPAPGPRHGHDAADGLSAPPLGHPATGGVPPLYPLLESALGIERAYEIAAAHPAVRGIALGEADLRAELGVADDAGLAWPRSRAVVAARAAGLAPPAQSVYPDVADLEGLARSCAAGRALGFLGRTAIHPRQLPVIERAFLPAPREVERAEEIVAAAAADAGALALPDGRFVDAAVVAEARRTLRLARRRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDL5</accession>
    <name>A0A0F7NDL5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">Octanoyltransferase</fullName>
            <ecNumber evidence="6 7">2.3.1.181</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Lipoate-protein ligase B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Lipoyl/octanoyl transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">lipB</name>
        <name evidence="12" type="ORF">AA958_07025</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6 7">Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6 7">
            <text>L-lysyl-[protein] + octanoyl-[ACP] = H(+) + holo-[ACP] + N(6)-octanoyl-L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17665"/>
            <dbReference type="Rhea" id="RHEA-COMP:9636"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:9928"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78463"/>
            <dbReference type="ChEBI" id="CHEBI:78809"/>
            <dbReference type="EC" id="2.3.1.181"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 6 7">Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="6">In the reaction, the free carboxyl group of octanoic acid is attached via an amide linkage to the epsilon-amino group of a specific lysine residue of lipoyl domains of lipoate-dependent enzymes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the LipB family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.181" evidence="6 7"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019837.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_07025"/>
    <dbReference type="EnsemblBacteria" id="AKH86590">
        <property type="protein sequence ID" value="AKH86590"/>
        <property type="gene ID" value="AA958_07025"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_07025"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1471"/>
    <dbReference type="OrthoDB" id="1806796at2"/>
    <dbReference type="UniPathway" id="UPA00538">
        <property type="reaction ID" value="UER00592"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033819">
        <property type="term" value="F:lipoyl(octanoyl) transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16444">
        <property type="entry name" value="LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00013">
        <property type="entry name" value="LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000544">
        <property type="entry name" value="Octanoyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020605">
        <property type="entry name" value="Octanoyltransferase_CS"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016262">
        <property type="entry name" value="LPLase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01313">
        <property type="entry name" value="LIPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="11">
        <location>
            <begin position="35"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6 9">
        <location>
            <begin position="73"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6 9">
        <location>
            <begin position="184"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6 9">
        <location>
            <begin position="197"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="6 8">
        <location>
            <position position="215"/>
        </location>
    </feature>
    <feature type="site" description="Lowers pKa of active site Cys" evidence="6 10">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR016262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR016262-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR016262-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR016262-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AKH86590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="260" mass="28730" checksum="C679611F52ADE980" modified="2015-07-22" version="1">MGELRFVHLGFGENAVEYLEAWQEQRRVHAARFAEEIPDTCLLLEHPPVYTAGRRTAEDERPLDGTPVVDVDRGGKITWHGPGQLVGYPILKLPRPVDVVAHVRRLEEALIRACADFGLATTRIEGRSGVWVLGDPVERRAELGGLALDFDPRLSDEEYDPRLAGPEYAPSNAGQRREDRKLAAIGIRVAKGVTMHGFSLNCNPDNTWFDRIVPCGIRDAGVASLSGELGRDVPVSEVLPVVEKHLREILETAEPLPRAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDL7</accession>
    <name>A0A0F7NDL7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH luxR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_28190</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018707.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_28190"/>
    <dbReference type="EnsemblBacteria" id="AKH85473">
        <property type="protein sequence ID" value="AKH85473"/>
        <property type="gene ID" value="AA958_28190"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_28190"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5942"/>
    <dbReference type="OrthoDB" id="1036370at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002831">
        <property type="entry name" value="Tscrpt_reg_TrmB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01978">
        <property type="entry name" value="TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="263"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH85473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="331" mass="35327" checksum="CA33307F5B3EE3EF" modified="2015-07-22" version="1">MLGAIGLDDVQETAYRALVALGAADVPELARRLTLPEPEAVRTLRRLEQHGLAAQSSARPGRWVAAPPSVALGALLIQQRHELERAELAAALLAEEYRAEAGEPADVHDLVEVVTGAGAVAHRFLQLQLGAEQEVCALVTREPLAVRSQDNTAEEKAAGRGVRFRVVLERSRLLAPGTVAEAAEALRRNEELRVADVVPTKLVIADGATAMVPMFAEAGEPAALVVHASGLLESLTGLFESLWRQALPLRLTTGGAAVVEQAAGGPDAVDLQILGLLLAGLTDASAAKQLDLGLRTVQRRVKRLMEIAGVHTRLQLGWYAHERGWCAEQRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDN2</accession>
    <name>A0A0F7NDN2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_24230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH84807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_24230"/>
    <dbReference type="EnsemblBacteria" id="AKH84807">
        <property type="protein sequence ID" value="AKH84807"/>
        <property type="gene ID" value="AA958_24230"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_24230"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5106"/>
    <dbReference type="OrthoDB" id="966287at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519979" evidence="1">
        <location>
            <begin position="25"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH84807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="376" mass="39159" checksum="23BA1E1A792F1E8A" modified="2015-07-22" version="1">MPLAVAAATALAGVAAGPSGQVVAAEKGSGTLSGDAPVEVIAKGLHSPRDLTWTPEGRLLVSEAGGIEQLCDNADIMTAKCFSTTGAITDVTDGKPKRIVEGLASNVNNAEVVGPNAMVYSEGKLHVLQAGHGIGLPKWLPRDLRTTLKNQYGRVLQVTEKKVKAVANPGAAGYKWMQENPDLVSEDPTSNPVSLAAKPGGGFYYVDAAANILGEIDRRGKVKVLKWFPKAPNGADAVPTCVDVGPDGAVYAGQLTGFGNTGNAAANIYRYDPKTGELKVWESGFATISGCGFGANGDFYVTQFDRTGFPPPGDPQGVVVQIAKDGTRTELGAGKLFAPQGFLAGPDGSIYVTNNTVWYPVGTTNRWDQGEVVKIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDN3</accession>
    <name>A0A0F7NDN3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AMP-dependent synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_28320</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018732.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_28320"/>
    <dbReference type="EnsemblBacteria" id="AKH85498">
        <property type="protein sequence ID" value="AKH85498"/>
        <property type="gene ID" value="AA958_28320"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_28320"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5969"/>
    <dbReference type="OrthoDB" id="326708at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="52"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="456"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH85498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="557" mass="60391" checksum="B301E6FE0FFBAD28" modified="2015-07-22" version="1">MTATNPTADFRSARDLLLARREDYAAARAAFSWPRPERFNWALDWFDAIAEGNERTALHIVEEDGRETRLSFTRMSERSNRVANWLRAQGVRAGDRIVVMLGNQAELWETALAAMKLRAVVIPATPLLGPADLADRIERGRAAHVLVRAADEAKFAEVPGGYTRISVGGSGAGWLPYEDAYEAPASFTPDGPTAADDTLMLYFTSGTTALPKLVEHTHVSYPVGHLATMYWIGIRPGDVHLNISSPGWAKHAWSNLFAPWNAEATVFLYNYTRFDAGALLDAMARGGVTTFCAPPTVWRMLVQSDLSGLATPPREAVAAGEPLNPEVIEAVRRAWNLTIRDGFGQTETAVQIANSPGQPVKLGSMGRPTPGYDVVLLDPVSGKPADEGEICLDLTARPVGLMTGYEGDPARTAEAMAGGYYRTGDIGARDAEGYITYIGRSDDVFKASDYKISPFELESALLEHEAVAEAAVVPAPDPVRLAVPKAYVVLAAGWEPGAAAAEAIFAHSRAVLAPYKRVRRLEFADLPKTVSGKIRRVQLREATAAGSADEYREEDHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDU9</accession>
    <name>A0A0F7NDU9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_29100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="1">Binds 1 [2Fe-2S] cluster per subunit.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018858.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_29100"/>
    <dbReference type="EnsemblBacteria" id="AKH85629">
        <property type="protein sequence ID" value="AKH85629"/>
        <property type="gene ID" value="AA958_29100"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_29100"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6133"/>
    <dbReference type="OrthoDB" id="1109542at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006221">
        <property type="term" value="P:pyrimidine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012165">
        <property type="entry name" value="Cyt_c3_hydrogenase_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006816">
        <property type="entry name" value="Cyc3_hyd_g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="2">
        <location>
            <begin position="3"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR006816-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH85629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="291" mass="31162" checksum="EC404242B813EFA3" modified="2015-07-22" version="1">MTAAPVPYRVVRRTEENADTATLVIEPTGEKLPLFRPGQFAMVCVPGVGETPVPVSGILEHRSRLTHTVRAEGPVPATLHAARPGRILGVRGPFGTGWTPEAADGGDVLVVAEGSGLAPLRPLVRSLLARTDRYDRISLLVGARSPADLLYRHELRCLNEASATHVAVTVDLPPDGWRGGVGTVTRQLDRAPFDPPTTTAFVCGPEAMIRATARELLRRGVPAQRIRVSLERNMHCAAGHCDHCRLGPVLLCREGPVVGYDRVADLLAVNELCDVRAQTGPFLPAPPTSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDV1</accession>
    <name>A0A0F7NDV1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_33965</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 130 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019633.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_33965"/>
    <dbReference type="EnsemblBacteria" id="AKH86411">
        <property type="protein sequence ID" value="AKH86411"/>
        <property type="gene ID" value="AA958_33965"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_33965"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.7172"/>
    <dbReference type="OrthoDB" id="1622507at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007184">
        <property type="entry name" value="Mannoside_phosphorylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34106">
        <property type="entry name" value="PTHR34106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04041">
        <property type="entry name" value="Glyco_hydro_130"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH86411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="359" mass="38405" checksum="A85580385B176D44" modified="2015-07-22" version="1">MTQLNAETALPYALKRIGVLMTADPADPLEAEGVLNPATAWGPDGHLYLFPRIVSAGNVSRIARARVVIEDGVPVGVERQGVVLAPDEGFERGARNAGVEDPRITFLADLGVHVMTYVAYGPLGPRPALAVSDDTVHWRRLGPLHFAYRPGLSTDLNFFPNKDLVFFPEVLPGPNGRPCFAMLHRPMWELDWLRPGEGAPAPAGVTDPRPSIWIAYADAGAVRADLSALTSLTHAAPVAGPQMPFEEAKIGAGPPPLRVPEGWLLIHHGVTGPVAKGFELSHGSVYRAGGILLDALDPSRVLARSPQPWLSPQIREETEGTLGNVVFPTAVEEIEGIPYVFYGMADSSIGVAALERTAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NDW6</accession>
    <name>A0A0F7NDW6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_34065</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_34065"/>
    <dbReference type="EnsemblBacteria" id="AKH86426">
        <property type="protein sequence ID" value="AKH86426"/>
        <property type="gene ID" value="AA958_34065"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_34065"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.7198"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
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        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
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        <property type="entry name" value="BCA_ABC_TP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12399">
        <property type="entry name" value="BCA_ABC_TP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="20"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="52"/>
            <end position="59"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH86426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="294" mass="31853" checksum="8AB488CE17E04A50" modified="2015-07-22" version="1">MRTARADHHPGRCIVSQVLLDVRDIAVQFGGVRAVDGLTFAVHEGEVLSVIGPNGAGKTSAFNCITGFYRPSAGSVTFAGTDITGKRTAAVAASGIARTFQNLRLFGDLTVLDNVRAGMHVRIKQNAFDAMLHTPRYRRSEDAATDEANRWLNFVGMEYDRAAQIRNLPYGEQRRVEIARALAREPKLLLLDEPAAGLNHGEKAQLLDLMRRIAGLGTAVVLIEHDMGLVMEVSERIVVLSHGKEIADGTPAEIRSNPAVIEAYLGADDEEAHVEVERIAAEANPGGPTTEVQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NEC6</accession>
    <name>A0A0F7NEC6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_08565</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019871.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_08565"/>
    <dbReference type="EnsemblBacteria" id="AKH86616">
        <property type="protein sequence ID" value="AKH86616"/>
        <property type="gene ID" value="AA958_08565"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_08565"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1807"/>
    <dbReference type="OrthoDB" id="1539946at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025326">
        <property type="entry name" value="DUF4232"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14016">
        <property type="entry name" value="DUF4232"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH86616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="258" mass="26915" checksum="B67C1495276C8D73" modified="2015-07-22" version="1">MDAGAPTAPGNPTPVEVDGVTVTRVHTNPETAEPVRVEFEIANRGSEAMTYTVAFEVRTASGEVLAYPEKIVESVPAGRTVPDQADVTAAMSGGRAAQVQIGEVRSVPADEAPSTGGPCPPTGVRLYADEGDAAMGLRVVGLHLENCGTEVHRLEGYPRVQLLDEEHAEVTGVRIRRGGAAIAAGTGADAPPRPLALQPGERASTQLVWRNTVEAGEAVNVPYVRVWAKPDSAPVTVTPELDLGTTGELGVGAWQKTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NEI1</accession>
    <name>A0A0F7NEI1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">UDP-glucose 6-dehydrogenase</fullName>
            <ecNumber evidence="4 7">1.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AA958_11470</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>H2O + 2 NAD(+) + UDP-alpha-D-glucose = 3 H(+) + 2 NADH + UDP-alpha-D-glucuronate</text>
            <dbReference type="Rhea" id="RHEA:23596"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="1.1.1.22"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nucleotide-sugar biosynthesis; UDP-alpha-D-glucuronate biosynthesis; UDP-alpha-D-glucuronate from UDP-alpha-D-glucose: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.22" evidence="4 7"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019962.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_11470"/>
    <dbReference type="EnsemblBacteria" id="AKH86691">
        <property type="protein sequence ID" value="AKH86691"/>
        <property type="gene ID" value="AA958_11470"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_11470"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2414"/>
    <dbReference type="OrthoDB" id="647136at2"/>
    <dbReference type="UniPathway" id="UPA00038">
        <property type="reaction ID" value="UER00491"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003979">
        <property type="term" value="F:UDP-glucose 6-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006065">
        <property type="term" value="P:UDP-glucuronate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017476">
        <property type="entry name" value="UDP-Glc/GDP-Man"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014027">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036220">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014026">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001732">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028357">
        <property type="entry name" value="UDPglc_DH_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00984">
        <property type="entry name" value="UDPG_MGDP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03720">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03721">
        <property type="entry name" value="UDPG_MGDP_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500134">
        <property type="entry name" value="UDPglc_DH_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000124">
        <property type="entry name" value="UDPglc_GDPman_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00984">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52413">
        <property type="entry name" value="SSF52413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03026">
        <property type="entry name" value="NDP-sugDHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 10" id="KW-0520">NAD</keyword>
    <keyword evidence="5 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDPG_MGDP_dh_C" evidence="11">
        <location>
            <begin position="327"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="160"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="260"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="271"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="334"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AKH86691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="446" mass="47970" checksum="A1A7730555B1A324" modified="2015-07-22" version="1">MTLKITVIGTGYLGATHAAAMAELGFDVLGLDVVEEKVELLSTGRVPMYEPGLEDLLRAHVSGVEGSSGRLRFTTSYEEAAAFGDVHFVCVNTPQKHGEYGCDMSYVDAAIDTLAPLLDRPCLVVGKSTVPVGSAARLARRLAELAPAGEEAELAWNPEFLREGFAVEDTLRPDRIVVGVASERAEKVLREVYAAPLDSGTPFVVADYPTAELVKTAANSFLATKISFINAMAEICEAAGGDVVKLAEAIGYDDRIGKKFLRAGIGFGGGCLPKDIRAFMARAGELGVDQALTFLREVDSINMRRRAHMVELAREACGGTFLGRRIAVLGAAFKPDSDDVRDSPALNVAGQIHLQGGQVTVYDPKGMDNARRVFPTLRYAESAEDALRGTDLVLHLTEWPEFRALDAGQLAQVVSRPHLIDGRNTLDPVPWRAAGWTFRAMGRPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NEN5</accession>
    <name>A0A0F7NEN5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PPM-type phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_30950</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019127.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_30950"/>
    <dbReference type="EnsemblBacteria" id="AKH85899">
        <property type="protein sequence ID" value="AKH85899"/>
        <property type="gene ID" value="AA958_30950"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_30950"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="PPM-type phosphatase" evidence="3">
        <location>
            <begin position="132"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH85899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="406" mass="41905" checksum="9485B6B312CA0569" modified="2015-07-22" version="1">MSVAAFVSSRWFVAALFVVITFADLVTARGQSLGALFSILPVLVAVNGGRRAVVAAGALGVVLAALLSWYNHDAGQARFFARFIAVVGATGLGLVLQAVRVDRERRLARAQRIADVAQRALLPVPPRRVGPFEVAATYASAAHDAQVGGDLYDVVGTGSGLRAVIGDVRGKGLPAVRIAGGALGVFRAVGHDERDLPLIGRRMEHSVLREAGPEDFVTVLLVEVTTGGRCTLLSYGHPPPLVRNVAGEVREAPVAAHPPIGLGLLRDPAPEDRADGGYGAAGASGGPGDAGVVSAADPAIDPLATPDSASARTTELILVPGDELLLVTDGVLEARNAAGEFYPLTPRYAGCLGPHDPPAEVLAALNADMRVYCGGELDDDSALVLLRYTPPLPGERSSSTGAVSPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NES6</accession>
    <name>A0A0F7NES6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HATPase_c domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_21385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_21385"/>
    <dbReference type="EnsemblBacteria" id="AKH86940">
        <property type="protein sequence ID" value="AKH86940"/>
        <property type="gene ID" value="AA958_21385"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_21385"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4502"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HATPase_c" evidence="1">
        <location>
            <begin position="2"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="99" mass="10464" checksum="7273EFC06B47E4F3" modified="2015-07-22" version="1">MAELAGNAVRHGHVPGRHFFVRVTRGGGRLQVEVDDAEPAPPVLTRAPDDAEEGRGLRIVDALADAWGVTPRPGGIGKTVWAVILYGTVSSRTDSAELP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NET4</accession>
    <name>A0A0F7NET4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">XRE family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_30625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019076.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH85848">
        <property type="protein sequence ID" value="AKH85848"/>
        <property type="gene ID" value="AA958_30625"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_30625"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6472"/>
    <dbReference type="OrthoDB" id="922937at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041413">
        <property type="entry name" value="MLTR_LBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17765">
        <property type="entry name" value="MLTR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="29"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="285" mass="30784" checksum="57FB8684DD97FB83" modified="2015-07-22" version="1">MELENLGTYLKTRRGRVTPAAAGLGTYGAARRVPGLRREELAQLAGVSAGYYTRLEQGQAGTASRQVLDALARVLRLDPAETAHLHNLARRPAAPRLARPAPEAPHPRVLALLTSLAETTPAVVLGRRGDVLAWNRTGHALVAEHVDFDAPGDPARRPSVPRMFFLDPLVRDQHANWAELARIHVAYLRLTAGRYPTDARLAELIGELAMGSGDFAELWAAGDVADCTVGTMRLRHPTVGALDVGYQVWLQPDSPGHRLEVYTPDDPASADALRLLSARSYPAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NF72</accession>
    <name>A0A0F7NF72_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_31465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_31465"/>
    <dbReference type="EnsemblBacteria" id="AKH85988">
        <property type="protein sequence ID" value="AKH85988"/>
        <property type="gene ID" value="AA958_31465"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_31465"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6648"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="115" mass="11958" checksum="C80FF001D50252DD" modified="2015-07-22" version="1">MAAGPPLAQRRTSGEISAAQRATAVRDAQVPALAQVFRVVRWDLPGHGRSPAGLLAAGGTVAHLARLVPDLVDALGELPRTGRLAPVERPEPVLAALLAHFAPAAYDQGNWYGPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFC2</accession>
    <name>A0A0F7NFC2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_31675</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020609.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_31675"/>
    <dbReference type="EnsemblBacteria" id="AKH87175">
        <property type="protein sequence ID" value="AKH87175"/>
        <property type="gene ID" value="AA958_31675"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_31675"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6689"/>
    <dbReference type="OrthoDB" id="1582456at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="282"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH87175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="304" mass="31906" checksum="3391EE256C459AD8" modified="2015-07-22" version="1">MSDLTGRRIFVTGAAGGIGRATAALAADRGAELYLTDLDGDRLDATAARIRARGGTVRYAGAADIADLDAVRAVADEVHAAADGPMDVVMNIAGISAWGTVEHLEHRHWRAMVEVNLMGPVHVIETFVPPMIAGGRGGHLVNVSSAAGLLGLPWHAAYSAGKFGLRGVSEVLRFDLRRHGIGVSLVCPGAVDTPLTETVEIVGVDKESKAFKRLQAGFRRQAESPEAVAGMILKGVARNRYLVHTSGRVRAAHGLQRAAPPLYALAMRAMNSATHRLLRRAVLGPPGRPAPGGDPGPRKDGGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFE1</accession>
    <name>A0A0F7NFE1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA polymerase sigma factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AA958_23605</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="WP_047020357.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_23605"/>
    <dbReference type="EnsemblBacteria" id="AKH86991">
        <property type="protein sequence ID" value="AKH86991"/>
        <property type="gene ID" value="AA958_23605"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_23605"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4975"/>
    <dbReference type="OrthoDB" id="1914729at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014293">
        <property type="entry name" value="RNA_pol_sigma70_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000838">
        <property type="entry name" value="RNA_pol_sigma70_ECF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02947">
        <property type="entry name" value="SigH_actino"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01063">
        <property type="entry name" value="SIGMA70_ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="7">
        <location>
            <begin position="42"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="8">
        <location>
            <begin position="148"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH86991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="231" mass="25614" checksum="2E0870A61531EF26" modified="2015-07-22" version="1">MGLVTGTDTGKGGAAEEPETPEETPEETSAERNARFERDALQFLDQMYSAALRMTRNPADAEDLVQETYAKAYASFHQFREGTNLKAWLYRILTNTFINSYRKKQREPQRSAAEEIEDWQLARAESHMSTGLRSAEAQALDHLPDSDVKEALQAIPEEFRIAVYLADVEGFAYKEIADIMGTPIGTVMSRLHRGRRQLRGLLEDYAQERGLMPAGAGPESAGSHTGKGSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-10-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFN1</accession>
    <name>A0A0F7NFN1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_28485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018761.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH85527">
        <property type="protein sequence ID" value="AKH85527"/>
        <property type="gene ID" value="AA958_28485"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_28485"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6002"/>
    <dbReference type="OrthoDB" id="1775418at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028978">
        <property type="entry name" value="Chorismate_lyase_/UTRA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011663">
        <property type="entry name" value="UTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07702">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00866">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF64288">
        <property type="entry name" value="SSF64288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="22"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH85527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="254" mass="27221" checksum="B25021ADD323AADC" modified="2015-07-22" version="1">MTKRGTGPVPALRLGVDRSSPVPLYFQLSQQLEAAIEQGALTPGSLLGNEIELAARLGLSRPTVRQAIQSLVDKGLLVRKRGIGTQVVHSQVRRPLGLTSLYDDLEAAGQRPATRVLGVAEVKATADVAAALGIAEGTDVVRVDRLRLTHGEPVALLCNHLPAELVGLRADELESTGLYRVLRAAGIALHSARQRVGARPATAAEAARLGEEEGAAVLTMERFTYDDTGRGVEFGSHLYRASRYSFEFQLLDRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-10-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NFR6</accession>
    <name>A0A0F7NFR6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_28755</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047018805.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH85572">
        <property type="protein sequence ID" value="AKH85572"/>
        <property type="gene ID" value="AA958_28755"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_28755"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6060"/>
    <dbReference type="OrthoDB" id="1439189at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="3"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH85572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="318" mass="34108" checksum="7BF91A9517EC4FB4" modified="2015-07-22" version="1">MDLELRHLKLVRAIAETGSLTRAAGRLGLAQSAISAQLKRIERALGGPLFVRDRAGARPTALGELVLDRAQVLLPAVRELQEEAVRFANAWEDMHRFRLGGTHGPLLGALVDRLAALHPDEPVSTYTSWSVQEISEMASSGRLDFALIGVCGESPPPAEDLEWRVVGTDPVFLMLAGDHPAADEPELELGRFREERWTTVPGEGCFGDCFSAACARAGFTPTPILETDTVSCAHLVQVGRAVGLCRATMPPTPGIATVPITGTPLSWRHLIGWHPESPAAGTAPAVLMYARAAHAEAARRNPVYAKWLAAHPEYGTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NGE5</accession>
    <name>A0A0F7NGE5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AA958_30485</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M48 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH85827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019055.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_30485"/>
    <dbReference type="EnsemblBacteria" id="AKH85827">
        <property type="protein sequence ID" value="AKH85827"/>
        <property type="gene ID" value="AA958_30485"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_30485"/>
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    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="278"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M48" evidence="8">
        <location>
            <begin position="115"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH85827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="304" mass="31997" checksum="C564D2F50E22B63C" modified="2015-07-22" version="1">MTTVLALVAYAALAGVVAPYALAGARWAYRAPKVAVVVWQGLMAAFVVTTASAGYQLALAEQHMHDGLVGLLSVCGLSRAATGSPAPTTANALLLLPPLVVVLMPTGWLLHCLRRTGRVRRRSLDMLALVGRQDPEYGVTVVDHPAAAVYCLPGRSGRIVVTQGALDVLTDAQLRAVLAHERAHLDGRHHLLHATTRAFRYAFPGLPLAGLGREQTALLLEMIADDRAMSSHPRDVLATAMYEVAAGQAPEAAFGAGGPGALIRLRRMLAPQHKPRRVTGWSLVAASLAAPLLPLLLACAPALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NGH9</accession>
    <name>A0A0F7NGH9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AA958_04535</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_04535"/>
    <dbReference type="EnsemblBacteria" id="AKH86544">
        <property type="protein sequence ID" value="AKH86544"/>
        <property type="gene ID" value="AA958_04535"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_04535"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.956"/>
    <dbReference type="OrthoDB" id="1437290at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041490">
        <property type="entry name" value="KstR2_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17932">
        <property type="entry name" value="TetR_C_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="10"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="4">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AKH86544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="197" mass="22245" checksum="3F2DD88F9B067C3E" modified="2015-07-22" version="1">MATTTGGNIGTVPERLLAAATRLFAERGFDRTSVQELVEAAGVTKGALYHYFGSKDDLLHEIYGRLLRLQQQRLDHFAALDAPVEQRLREAAADVVVTTVDHHEDALIFFRSMHMLSPEKYKEVRAERRRYHERFRGLIEEGQAGGVFSTATPADLVVDYHFGALHHLGSWYRPDGPMSAREIGDRMAELLMRALRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2020-12-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NGP0</accession>
    <name>A0A0F7NGP0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SSD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AA958_08050</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86604">
        <property type="protein sequence ID" value="AKH86604"/>
        <property type="gene ID" value="AA958_08050"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_08050"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1698"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004869">
        <property type="entry name" value="MMPL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03176">
        <property type="entry name" value="MMPL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="266"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="328"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="496"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="526"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="563"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="612"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="638"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="8">
        <location>
            <begin position="162"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="690"/>
            <end position="709"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKH86604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="709" mass="75821" checksum="AC09FE37A02E84BD" modified="2015-07-22" version="1">MGGYESTGTESYKAAQELEKTFEQGEPNLALVVEDARGVDDPEVAAAGGRLTEKLADEADVTNVVSYWSSDQAPALRGESGEQALVLGRITGDFDDVIDRVEKLDEDYTGKVDGLEVTTGGSAMMWLENTTKAAEDATKAEFMVFPLVLLVLIIIFGGVVAALLPLSVAICAMLTSMGVLFGITFAMDTSNVVVNTTTFLGIGLGIDYSLLFVTRYREELRRGKEIGAAISTTLHTAGRTVLFSAFTVAAAFLGLLVLPFTMMRSLAIGCIVTSLLAAFLTVVLLPGLLKWLGPRIEKWRLIRRKSDPSEDGGGSWHKLATGVMRRPIAVTVLVLAIVIPLGLPALNMNLRLPDESVLATDAQSAEVASVLREDFDSREQQPVQIVATNTGAPDQQTGEIDDYAKRLSELPGATRVDTLTGTYQDGQLAAEPGPASARFAVDDGVYFSMIPAADPYSDAGTDLVEDVRAEKAPFDVQVGGQAAVSTDTFDTLVDRLPIAGAILFVIMFILLFLLTGSILLPLKAMVLTALSLTATFGALVFIFQDGNLMWLVGDFVETGGITWTAPIMIFAMAFALSMDYEVFMISRIKEEYDRTGDNELAVASGLERVGKVVTYAALLLSLVFLVLLTSGISYMKAIGIGMALAIVMDATLIRGGLLPAFMKLMGSANWWAPKPLKALHTRFGIREGEEMGPTPAATGTDASLAAQKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NGQ8</accession>
    <name>A0A0F7NGQ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Long-chain fatty acid--CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_01395</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019705.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_01395"/>
    <dbReference type="EnsemblBacteria" id="AKH86483">
        <property type="protein sequence ID" value="AKH86483"/>
        <property type="gene ID" value="AA958_01395"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_01395"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.308"/>
    <dbReference type="OrthoDB" id="377638at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="23"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="450"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH86483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="537" mass="58381" checksum="5E5CB5472ED74554" modified="2015-07-22" version="1">MAMMDIPLNSWLLFDHGPRYFHDTEVVTRFPDGSRHRYTYADFGRRAQQLMHALDSLALPPGARVATLAWNGYRHLEAYWAVPCTGRVLHTLNVRLSADELAYIVKHADDRVVLVDADLLPLLEQVAERGGLAGVDHVVVLADRVPAGTTLPGTLAYEELIAAQPVTYEPREIDERAPLGLCYTSGTTGRPKGVVYTHRSTMLHALAGSSRAAMSIGPGDAVLPVVPMFHANAWGLPYTATPYGAKQVFYGGPLDEAALVELMAEERVTVAAGVPTVWMAVADALAARGGGLPDVRHLLCGGARPARALIDRYRTEFGIPLVQIWGMTETSPLASFAWPKERMRGWDEERLADAVRGMAGLPLPGVQTQIRDGNGRPLPWDGASMGELLVRGPWVADAYLGEEGGGQFTEDGWFVTGDIATGTPDGYFVITDRAKDLVKSGGEWISSVDMESAVMAMDAVAEAAVVAVPDERWSERPLVCVVVRHGATVTLDEVRTHLERSGFARWQLPDRVELVDAVPRTGTGKFDKKALRARFAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NHB8</accession>
    <name>A0A0F7NHB8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Terpene synthase</fullName>
            <ecNumber evidence="2">4.2.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_32285</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the terpene synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.-" evidence="2"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019355.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_32285"/>
    <dbReference type="EnsemblBacteria" id="AKH86127">
        <property type="protein sequence ID" value="AKH86127"/>
        <property type="gene ID" value="AA958_32285"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_32285"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.6816"/>
    <dbReference type="OrthoDB" id="1869158at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034686">
        <property type="entry name" value="Terpene_cyclase-like_2"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01020">
        <property type="entry name" value="Terpene_Cyclase_Like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU366034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH86127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="338" mass="37523" checksum="75CE0652F01D0AAC" modified="2015-07-22" version="1">MTPVEVTFPPIWCPFPARLHPEAAGLDDHVIAWARHADLIRDGSAVTHFHRAGFGRFAAAVYPRAGRLELVAEWQVYNWIVDDQLDEGHMARTPAQRLRTATELGAQLDPDLDAPAPAGPLAAALADLWERTAKPFSRAWRERFAAHYRDFLWYTILPHAEPARIPGQTLADFTRRRRLNSGCEMSFDLIEPANSTEIPAAVAASDAYRAARDAANDVISWTNDIYSVHKETARGDHDHLAAVLWRLEGGTRQAALDRAAAMVGRRTEDFRSACQDVRGMKPLFGLDPHGWAVVEDSLTDLGSWIAGSLEWHGWSPRYREVAATRAGSAPAYVEPHLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NHJ6</accession>
    <name>A0A0F7NHJ6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH arsR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_14930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020076.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_14930"/>
    <dbReference type="EnsemblBacteria" id="AKH86778">
        <property type="protein sequence ID" value="AKH86778"/>
        <property type="gene ID" value="AA958_14930"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_14930"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3146"/>
    <dbReference type="OrthoDB" id="1772343at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="18"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="137" mass="14270" checksum="2A61547A20110472" modified="2015-07-22" version="1">MGHGAATPGASDGGRVRLDAATAQKVAATLQALATPSRLLILARLREGPLPVSELAAEVGMEQSACSHQLRLLRNLGLVTGTRHGRSIVYALYDDHVAALLDQALHHTEHLRLGLTDTPAGAGRDDLLGEESAAARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NHM7</accession>
    <name>A0A0F7NHM7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminotransferase</fullName>
            <ecNumber evidence="1">2.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_21005</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.-" evidence="1"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020283.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_21005"/>
    <dbReference type="EnsemblBacteria" id="AKH86934">
        <property type="protein sequence ID" value="AKH86934"/>
        <property type="gene ID" value="AA958_21005"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_21005"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4425"/>
    <dbReference type="OrthoDB" id="554560at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="2">
        <location>
            <begin position="44"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH86934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="411" mass="43822" checksum="54605C4F5BE085AC" modified="2015-07-22" version="1">MTAANTASQSPTERRVSARVGAISESATLAVDAKAKALKAAGRPVIGFGAGEPDFPTPDYIVEAAIAACTNPTYHRYTPAGGLPELKAAIAAKTARDSGYEVEPAQVLVTNGGKQAIYESFAALLDPGDEVIVPTPYWTTYPESIRLAGGVPVDVVADETTGYRVSVEQLEAARTPRTKVLLFVSPSNPTGAVYAREQVEAIGRWAAEHGLWVLTDEIYEHLVYGTAEFHSLPVVVPELRDKCVVVNGVAKTYAMTGWRVGWAIGPKDVIKAAANLQSHATSNVSNVAQAAALAAVSGDLDAVAKMREAFDRRRRTIVRMLNEIEGVECPEPEGAFYAYPSVKGLLGKEIRGRRPANSVELAEVILEEAEVAVVPGEAFGTPGYLRLSYALGDEDLVEGVSRMQKLLAEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NHQ1</accession>
    <name>A0A0F7NHQ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_16980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020147.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86833">
        <property type="protein sequence ID" value="AKH86833"/>
        <property type="gene ID" value="AA958_16980"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_16980"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.3571"/>
    <dbReference type="OrthoDB" id="282002at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="546"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="582" mass="63567" checksum="C22F6A7CDE33EE0F" modified="2015-07-22" version="1">MTTTGPPADGHTPQPADEDSSGPSSGDAREDGADTHVAPREPEPGPAAPPPTLLRVELAKRGWARFSTFEVHYTHAARKAAAEYGDPRLARLTISSTTFKRWLAGEQIPRGNAGTVLEHMLGIDVDALLGPAPTRTFTTPRLPDDASLATARALDVTWSTSFLSPTAPAPGGGGVWQLDGHRVFDGTSVAVQLYEAEAGSDSVVIGPDDHPHLRDFIRPARRALLLAALGARRGEGLFVLDAVRARQPVAADPVDVLPIPRAYRLDDLTYAVLWAVLNLDDGLLADDAVLEAERSGLDDFLTRERSAVARSAMPELSDVGTAWLGSYVCDRHILRELRAGSGEPPVFWAREQFGEEAAAWLFFRHKHTYLRALHDLLADADRPYGYAFCLPHNAVKTSERYERTLLFLTLALLERHGLTTWVVTEPEYAQVDGFALVPGERAIIANWLRTDGIWQVDTTSHWARLRAYADAVRHARTHSVTDGATPAERLRRLADHLDLDWAWLTDRCAELARYGSAGMLRPRSRLIGLAELDDVLRYVGELGPGDPAGREAADGDPGVFAGAVTGGNRTQFRPDRHHGGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NHZ8</accession>
    <name>A0A0F7NHZ8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sigma70_r2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_33650</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047019579.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH86357">
        <property type="protein sequence ID" value="AKH86357"/>
        <property type="gene ID" value="AA958_33650"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_33650"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.7105"/>
    <dbReference type="OrthoDB" id="1914729at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="26"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="90"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH86357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="203" mass="21063" checksum="A6B4C83E0C2E2C9F" modified="2015-07-22" version="1">MAEADAPLAEAIRAARAGDETAFVRLYRSLHPCLVRYVGTLVGDAAGDGDAEEVTAGAWQDIARDLRAFDGDAPGFRAWCARIARTRALTHLRDRPGPGPRDSGGGPRPEGVPGRPEGGRSLALIAWLPRAEADAVALRVIVGLDAERAAYVLGTSPAAARSATLRGLRLLADQLGDAAVGACPAGAPAEDATCTATWMLRGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NI24</accession>
    <name>A0A0F7NI24_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_19965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH86918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047020264.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_19965"/>
    <dbReference type="EnsemblBacteria" id="AKH86918">
        <property type="protein sequence ID" value="AKH86918"/>
        <property type="gene ID" value="AA958_19965"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_19965"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.4206"/>
    <dbReference type="OrthoDB" id="1478362at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="6"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH86918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="267" mass="29951" checksum="8B142C31E901CD2B" modified="2015-07-22" version="1">MFGDVLKHLREAAGMTQAELAKLIPCDRSYVARVETGTSVPPDTFAEKCDEVLGGNGLLARLWLKVDWYPDVAHPDWFERRAKMDAECVALRAYQEGVVPGLLQTELYAQALFARVSEDEEKVEERVRARLSRQQRFFSPQGPLYIAVIDESCLRNVVGGPEVMRMQCEHLLTAGQRANIQIQVAPADRPELIRPRGSMSLITLPDDEKWAYAEALDHGYFSGNPAAFEQHLRTYDVLRADAMSARESATLIGEFMEGYGQHGHDLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NIF2</accession>
    <name>A0A0F7NIF2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable membrane transporter protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_26240</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_26240"/>
    <dbReference type="EnsemblBacteria" id="AKH87043">
        <property type="protein sequence ID" value="AKH87043"/>
        <property type="gene ID" value="AA958_26240"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_26240"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5523"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002781">
        <property type="entry name" value="TM_pro_TauE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01925">
        <property type="entry name" value="TauE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="130"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="225"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="249"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="266"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH87043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="304" mass="31005" checksum="4C6261900FAA775F" modified="2015-07-22" version="1">MVGLTGMGGGALMTPLMVTVFGVNPTQAIGSDLATSVFMKPFGAAVHQKAGTVRWDVVRWLLPTGVPAAFCGAFLLQFLGEGDDLQSRVKIVIGAALLLAVTGMLARMWLDRRRAAQGEETEDAHVPVRPVPTLVIGLVGGLVVGMTSVGSGSLIIVMLMLVHPRLKANHLVGTDLVQAIPIVAAAAGGHFLVGDASLGLAAVLLLGAIPGVLVGAVLSTRAPGAVLRWVLAIILLATGLSLVHVPETVIVPACAVLAAYAVISSRPRRPRPATAPAGAPAVDGESTGEPPADGIERASAPRQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7NJW3</accession>
    <name>A0A0F7NJW3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_27800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ROK (NagC/XylR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH87072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_27800"/>
    <dbReference type="EnsemblBacteria" id="AKH87072">
        <property type="protein sequence ID" value="AKH87072"/>
        <property type="gene ID" value="AA958_27800"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_27800"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.5860"/>
    <dbReference type="OrthoDB" id="1130699at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01125">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="2">
        <location>
            <begin position="17"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH87072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="401" mass="40699" checksum="950621ED2E901D9E" modified="2015-07-22" version="1">METPGSQSSLHRANLERVVRAVRLSGSLTQAQIARSTGLSAATVSNIVRELQESGTVSVTPTSAGGRRARAVSLSGDAGIVVGVDFGHTHLRVAVGNLAHQVLAEESEPIDVDASATQGLDRAEALVSRLVGATDVPADKVVGVGLGVPGPIDTETGVLGSTSILPGWTGTNPRDDLQSRLGVPVYVDNDANLGALGELVWGSGRGAKDVAYIKVASGVGAGLVINGQLYRGPGGTAGEIGHITLDESGPVCRCGNRGCLETFTAGRYILGLLEASHGPGLTVEHMVQLARDGDPGCRRVIADVGRHIGSGVASLCNLLNPSRVVLGGDLAEAGELILQPIGESVARYAIPSAARQLDLASGALGSRAEVLGALALVLSEMGDRSILDGAVPVLAPALTDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MXI0</accession>
    <name>A0A0F7MXI0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_00765</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH80940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014306.1">
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    </dbReference>
    <dbReference type="STRING" id="444103.AA958_00765"/>
    <dbReference type="EnsemblBacteria" id="AKH80940">
        <property type="protein sequence ID" value="AKH80940"/>
        <property type="gene ID" value="AA958_00765"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_00765"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.173"/>
    <dbReference type="OrthoDB" id="428846at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.110.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037398">
        <property type="entry name" value="Glyco_hydro_64"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032477">
        <property type="entry name" value="Glyco_hydro_64_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037176">
        <property type="entry name" value="Osmotin/thaumatin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38165">
        <property type="entry name" value="PTHR38165"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16483">
        <property type="entry name" value="Glyco_hydro_64"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519030" evidence="2">
        <location>
            <begin position="41"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_64" evidence="3">
        <location>
            <begin position="135"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_64" evidence="3">
        <location>
            <begin position="243"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH80940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="333" mass="36156" checksum="29D145C336BC0E0D" modified="2015-07-22" version="1">MFPAHPTWPRRHRGLLTAVVALLLFACYAVADRAGTAAHAAVPPAAGPASTASAAPGDPPPASFWGDTGAIPPARNVLTVQILNRTNGQYPDDQVFWSFGGQTRSIAQQRYVDMPANSAGRMYFHLGSPDSRYSDFIEFTVGPDAFHGNTTRVDAFALKLAMRVHGHDGTDRQVGEDYATFQESREATWQKFAAAMPPEFASLSQVQAPYRIPSPGNVPDFQPGGKHAAYMTDYARSVGRNVTTQEVFGCSGPLAGDAPGCAALNRHVAELPQNQWGDPSRFYRQGPANYYAQFWHQQAIGGLAYGFPYDDVAEQSSFVSVQDPQWMVVAVGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MYC2</accession>
    <name>A0A0F7MYC2_9ACTN</name>
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        <submittedName>
            <fullName evidence="3">ROK family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_02475</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ROK (NagC/XylR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014588.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_02475"/>
    <dbReference type="EnsemblBacteria" id="AKH81225">
        <property type="protein sequence ID" value="AKH81225"/>
        <property type="gene ID" value="AA958_02475"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_02475"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.529"/>
    <dbReference type="OrthoDB" id="1130699at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="209"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH81225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="438" mass="43530" checksum="6CFC1B88DBAB1309" modified="2015-07-22" version="1">MSAPSPRTQQALRQRNLSLALRAVAAGGPLSRAAVAARIGMTRAGVAAVVDELLRAGLLVELGPGRPGTVGRPGSALALNDRGPCGLGAEIGVDHLAVCAVDLRGRVRARVAADAANRDHPPGPVLARLAGLIEEVVAEVRGEGLTPTGLTVAVPGLIARDESTVVRAPNLGWQGVDLGPLLPAAPPARVGNEANLGALAEQRLERTAAEPPGTGADGEPGPGPALDPGDRQDAALPAGDHGSPGPGRNFLFVSAEIGIGAAVVMDGELLRGAHGFAGELGHVPVRPQGRPCACGGRGCLEQYAGEEAVLRASGIEPAGARAAHPGPGARIAMLAARAGDGDALVRTALREAGGALGIALAGAVNLLDPETVVLGGALAGLGPWVVPAVERELGRRLADPARTVRLTVSALGAEGPLLGAALSEVDAVMEAPGAVTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MYI4</accession>
    <name>A0A0F7MYI4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_02870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014653.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH81290">
        <property type="protein sequence ID" value="AKH81290"/>
        <property type="gene ID" value="AA958_02870"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_02870"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.614"/>
    <dbReference type="OrthoDB" id="644190at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH81290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="305" mass="33686" checksum="9068821EC9D5FE85" modified="2015-07-22" version="1">MAFDIPGYINTAGRVQVDDLDLDAFAERPLSAEALRCLRYMSDVESHTVCYLRDVLVTPSHRDPDVTAFMSMWAFEEFWHGEAIDSVLRAHGQKADYDHIREVREAQGLKDRLAPIYQSIAANAIGDDFVAVHMTWGAINEWSAHAAYGSLIEKEQHPELTKLLGRIQRQESRHLAFYASQAKERLERSQRARSLARWVTERFWQPVGSTIQPVEETQFVLRHLLGDDAGATAVRKIDEKVHKLPGMEGLNLVQRGVAGFGVGVPVGDLGAAKRGSRKRLVAGAAVVAGAAGIAAVRRRSAGSHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MYU8</accession>
    <name>A0A0F7MYU8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_03615</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014783.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_03615"/>
    <dbReference type="EnsemblBacteria" id="AKH81425">
        <property type="protein sequence ID" value="AKH81425"/>
        <property type="gene ID" value="AA958_03615"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_03615"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.761"/>
    <dbReference type="OrthoDB" id="1437290at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041583">
        <property type="entry name" value="TetR_C_31"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17940">
        <property type="entry name" value="TetR_C_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="16"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH81425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="186" mass="19799" checksum="E6DB95990FDE3BE0" modified="2015-07-22" version="1">MRTETGAADGRVQRGQERRRLLLAATVRVIGRGGVAAVTHRAVAAEAGVPKSVATYHFPAVADLLAAALSDSVDAYATALAGALPESYDTADLGRHLAAYLDEHGARCAAEFDLYLYAARHPELRPVLGRWHDLLAGIAGRFTSDPVAVTAFSAALDGLSLQSLLRDEPLTAAEIQQVVDHVLHRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7MZ52</accession>
    <name>A0A0F7MZ52_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Beta-ketoadipyl CoA thiolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_04455</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014920.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_04455"/>
    <dbReference type="EnsemblBacteria" id="AKH81565">
        <property type="protein sequence ID" value="AKH81565"/>
        <property type="gene ID" value="AA958_04455"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_04455"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.939"/>
    <dbReference type="OrthoDB" id="550338at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="5">
        <location>
            <begin position="7"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="6">
        <location>
            <begin position="276"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="3">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="352"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH81565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="396" mass="40822" checksum="C5DC97F0C7E93B8F" modified="2015-07-22" version="1">MRTVHFAAARRTPIGKLRGSLSAVRPDDLAAGVIRGLLDGVPALDPARIDDVYWGAANQAGEDNRNVARMAALLAGLPESVPGATLNRLCASGLEAVTTAARAIAAGEADVVLAGGSESMSRAPFVLPRPDEALPRAMATADTRLGWRLVNPRMRDLHGLLAMGETAEEVAGKYGVGRARQDEFALRSHRRAAAARAAGHFDAELLPVVRPEGAAPVTADECIREDTSAAQLAKLKPVFREGGSVTAGNSSPMNDGAAALLLVSEEALAELGLESLGRYAAGASAGVHPDVMGIGPVPATRKALDRLGWSVADVETAELNEAFAAQSLACVDELGLDPETVNPDGGAIALGHPLGCSGARILTTLLHRMARTGARRGLATMCVGVGQGSAVLVERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N030</accession>
    <name>A0A0F7N030_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phospho-N-acetylmuramoyl-pentapeptide-transferase</fullName>
            <ecNumber evidence="7">2.7.8.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">UDP-MurNAc-pentapeptide phosphotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mraY</name>
        <name evidence="8" type="ORF">AA958_06545</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine = di-trans-octa-cis-undecaprenyl diphospho-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + UMP</text>
            <dbReference type="Rhea" id="RHEA:28386"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:60392"/>
            <dbReference type="ChEBI" id="CHEBI:61386"/>
            <dbReference type="ChEBI" id="CHEBI:61387"/>
            <dbReference type="EC" id="2.7.8.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyltransferase 4 family. MraY subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.13" evidence="7"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015277.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_06545"/>
    <dbReference type="EnsemblBacteria" id="AKH81925">
        <property type="protein sequence ID" value="AKH81925"/>
        <property type="gene ID" value="AA958_06545"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_06545"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1366"/>
    <dbReference type="OrthoDB" id="1151822at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008963">
        <property type="term" value="F:phospho-N-acetylmuramoyl-pentapeptide-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051992">
        <property type="term" value="F:UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine:undecaprenyl-phosphate transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06852">
        <property type="entry name" value="GT_MraY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00038">
        <property type="entry name" value="MraY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000715">
        <property type="entry name" value="Glycosyl_transferase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003524">
        <property type="entry name" value="PNAcMuramoyl-5peptid_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018480">
        <property type="entry name" value="PNAcMuramoyl-5peptid_Trfase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22926">
        <property type="entry name" value="PTHR22926"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00953">
        <property type="entry name" value="Glycos_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10555">
        <property type="entry name" value="MraY_sig1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00445">
        <property type="entry name" value="mraY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01347">
        <property type="entry name" value="MRAY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01348">
        <property type="entry name" value="MRAY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0133">Cell shape</keyword>
    <keyword evidence="7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="230"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="279"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="323"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AKH81925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="356" mass="38379" checksum="8A32CDAD6F91AC00" modified="2015-07-22" version="1">MRQILFSGALGLFLSLLGTPLLIKLLARRGYGQYIRDDGPQAHHSKRGTPSMGGIAFILATIIAYAITKVVTSSSPTYSGLLVLFLMAGLGLVGFLDDYIKIIKQRSLGLRAKAKMLGQFIVGIAFAVLSLNFEDARELTPASTKLSFTQDFGWSIGPVLFVIWALFMILAMSNGVNLTDGLDGLATGASVMVFGAYVFIGVWQYQESCINADTLTNPAACYDVRDPLDLAVVASALMGACFGFLWWNTSPAKIFMGDTGSLALGGALAGLAIASRTELLLAILGGLFVLITLSVVIQVGSFRMTGKRVFRMAPLQHHFELKGWSEVLVVVRFWIIQGMCVIVGLGIFYAGWAARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0F3</accession>
    <name>A0A0F7N0F3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">AA958_03820</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014818.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_03820"/>
    <dbReference type="EnsemblBacteria" id="AKH81461">
        <property type="protein sequence ID" value="AKH81461"/>
        <property type="gene ID" value="AA958_03820"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_03820"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.803"/>
    <dbReference type="OrthoDB" id="923655at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023834">
        <property type="entry name" value="T7SS_pept_S8A_mycosin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03921">
        <property type="entry name" value="T7SS_mycosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 15" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0720">Serine protease</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519638" evidence="13">
        <location>
            <begin position="34"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="367"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S8" evidence="14">
        <location>
            <begin position="57"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="397"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="401"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AKH81461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="445" mass="45498" checksum="183C7BA7D0333E25" modified="2015-07-22" version="1">MTRPFRVHRRAAALLAALAAAALLGATAAPAHADGLQELQWGLDDVRAPEAWNTTRGEGVTVAVLDTGVDAGHPDLTGQVLDGKDFVGFGARRGDDSWARHGTAMAGIIAAHGHGPGAAEGVTGVAPDAKILPVRVILEDGDAQRGKARETRGSALADGIRWAVDNGADVINLSLGDDSKSAHPEPGEDAAVQYALRKGVTVVSSAGNSGEKGDRISYPAAYPGVIAVTAVDRTGARADFSTRHWYATVAAPGVDVAIADPDRTYYEGWGTSAAAAFVSGVTALVRAANPDLTPWQIRDLLRETAQDPPEGGRDDELGAGRVDAAAAVAAARELKAAPQEPKSAAYDEKRFGSAPALVATEDDGPNGLALAAGVIGVGLIAGAWFLWRGPRSRAAGVWRGPEPPPFAPPPAGPSRSAPPPGAAGPRPRGDDGRPLGSSGVAEEHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0G5</accession>
    <name>A0A0F7N0G5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AA958_03910</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CNQ-509</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014833.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_03910"/>
    <dbReference type="EnsemblBacteria" id="AKH81476">
        <property type="protein sequence ID" value="AKH81476"/>
        <property type="gene ID" value="AA958_03910"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_03910"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.821"/>
    <dbReference type="OrthoDB" id="1891092at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="24"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="104"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="141"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="9">
        <location>
            <begin position="8"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AKH81476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="258" mass="27624" checksum="D31547CB68A136FB" modified="2015-07-22" version="1">MSALAAHTWYMTQRQLTAFLRQPAYLLITLVQPVIWLFLFGNLFREITELPGFGTGSYLDYLVPGVVVMTALSSSMWAGMGTLEEIERGTLNRFLTTPVSRGALMNANVVNNGLSVFVQSVVIVLLGLLGGADYAGGAAGLLVLVAAAILLGTVFGAMSNAIGMVVRQRESIIGINTFLLLPLTFLSSAFMAPALMPAWMRHIADANPVDWAVVAGRGALSADPDWGEVLLRCGGLLAVAVAAVWLSTRTFRTYQRSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N0K2</accession>
    <name>A0A0F7N0K2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_00745</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH80938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014304.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_00745"/>
    <dbReference type="EnsemblBacteria" id="AKH80938">
        <property type="protein sequence ID" value="AKH80938"/>
        <property type="gene ID" value="AA958_00745"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_00745"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.169"/>
    <dbReference type="OrthoDB" id="1542506at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009366">
        <property type="term" value="C:enterobactin synthetase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009239">
        <property type="term" value="P:enterobactin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008278">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041354">
        <property type="entry name" value="4PPT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003542">
        <property type="entry name" value="Enbac_synth_compD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17837">
        <property type="entry name" value="4PPT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01648">
        <property type="entry name" value="ACPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01399">
        <property type="entry name" value="ENTSNTHTASED"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56214">
        <property type="entry name" value="SSF56214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Metallophos" evidence="2">
        <location>
            <begin position="7"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="4PPT_N" evidence="4">
        <location>
            <begin position="331"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="ACPS" evidence="3">
        <location>
            <begin position="405"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH80938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="529" mass="58422" checksum="EB0594505BE8C747" modified="2015-07-22" version="1">MALMHGRLLAVSDLHVAYQENRDITAGLRPTAPGDWLIVAGDVGERVSDIEWTLGLLAERFAKVVWVPGNHELWTHPDDPVTLRGEERYRHLVELCRGLGVVTPEDPYPVWDGEGGPVTIAPLFVLYDYSFRVPGAATKEESLRLAHEAGVVCTDEYFLHPDPHTSRDAWCRERVALTERRLAAVDPAHRTVLVNHWPLVRQPTDILRYPEFAQWCGTTLTADWHRRFRAAAVVYGHLHIPRVTWYDGVKFTEVSLGYPREWKRRPPRELLRTVLPPSSTTTAAAPAGRPRELTTTPERARLLQELLPGGVTAAEAFTDPPEPPAERLYPEEARAVARAVPHRQAEFATVRQCARRALGALGVEPAPLLPGRRGAPQWPAGIVGSMTHCAGYRAAAVARRGEVIGIGIDAEPNEPLKDGLLEAVGLPEEQEQVRARMRGPSEVCWDRLLFSAKESVFKVWYPLTARELDFDEARIDVDPDKGTFTARILVPATTVDGISLAHMNGRWLCRSGLLVTAVALAAGAGGDGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N198</accession>
    <name>A0A0F7N198_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">APH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AA958_02260</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the aminoglycoside phosphotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014552.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH81188">
        <property type="protein sequence ID" value="AKH81188"/>
        <property type="gene ID" value="AA958_02260"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_02260"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.485"/>
    <dbReference type="OrthoDB" id="1457558at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05150">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024165">
        <property type="entry name" value="Kan/Strep_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000706">
        <property type="entry name" value="Kanamycin_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APH" evidence="6">
        <location>
            <begin position="14"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000706-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000706-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AKH81188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="271" mass="28907" checksum="3D9D431AB6AA33DB" modified="2015-07-22" version="1">MTAELRARYASYDWQPVTDGMSGAGVWRLTGPGELFVKTAAAGDGPAEPGADLRHEAACTRWLRAQGLPAPEVLDAGAADGTTWLVTRARPGRSLAEPWPADLRAGAVEALARFTRRLHELPVADCPFVRNLSVTVPLAGAAVAAGLVDEEDFDDGRRGRSAAGLFAELERTRPAVEDLVVCHGDLCAPNVLVDPATLEVSGVIDLGRLGVADRHLDLALAVRSFSDEDLNPQHGPAAAGLFLRTYRAAGEGDVRVDPARTEFYTLLDEFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N1L0</accession>
    <name>A0A0F7N1L0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Carbamoyl-phosphate synthase large chain</fullName>
            <ecNumber evidence="15">6.3.5.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Carbamoyl-phosphate synthetase ammonia chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15 19" type="primary">carB</name>
        <name evidence="19" type="ORF">AA958_03110</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>2 ATP + H2O + hydrogencarbonate + L-glutamine = 2 ADP + carbamoyl phosphate + 2 H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="15">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="15">Binds 4 Mg(2+) or Mn(2+) ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="15">Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 15">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the CarB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.5" evidence="15"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014693.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_03110"/>
    <dbReference type="EnsemblBacteria" id="AKH81333">
        <property type="protein sequence ID" value="AKH81333"/>
        <property type="gene ID" value="AA958_03110"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_03110"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.663"/>
    <dbReference type="OrthoDB" id="48855at2"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00171"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01424">
        <property type="entry name" value="MGS_CPS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1030.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01210_B">
        <property type="entry name" value="CPSase_L_chain_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006275">
        <property type="entry name" value="CarbamoylP_synth_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005480">
        <property type="entry name" value="CarbamoylP_synth_lsu_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036897">
        <property type="entry name" value="CarbamoylP_synth_lsu_oligo_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CbamoylP_synth_lsu-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005483">
        <property type="entry name" value="CbamoylP_synth_lsu_CPSase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033937">
        <property type="entry name" value="MGS_CPS_CarB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02787">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02142">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00098">
        <property type="entry name" value="CPSASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01096">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01369">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="5 15" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="11 15 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 15 19" id="KW-0436">Ligase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 15 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13 15" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 15" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ATP-grasp" evidence="17">
        <location>
            <begin position="138"/>
            <end position="334"/>
        </location>
    </feature>
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        <location>
            <begin position="685"/>
            <end position="876"/>
        </location>
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            <begin position="958"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carboxyphosphate synthetic domain" evidence="15">
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            <begin position="1"/>
            <end position="408"/>
        </location>
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            <begin position="958"/>
            <end position="1106"/>
        </location>
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        <location>
            <position position="291"/>
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        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
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            <label>2</label>
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        <location>
            <position position="835"/>
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            <label>3</label>
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        <location>
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        <location>
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            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>4</label>
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    </feature>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="AKH81333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
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    </evidence>
    <sequence length="1106" mass="117808" checksum="2442AF5C04384E40" modified="2015-07-22" version="1">MPKRTDIRSVLVIGSGPIVIGQAAEFDYSGTQACRVLRAEGLRVILVNSNPATIMTDPEIADATYVEPITPEFVEKIIARERPDALLPTLGGQTALNTAVSLHDSGVLEKYGVELIGANVEAIQKGEDRDQFKEVVAEVRRKTGHGESARSVICHTMDEVLAGVDGLGGYPVVVRPSFTMGGAGSGFAHDEEELRRIAGQGLALSPTTEVLLEESILGWKEYELELMRDKHDNVVVVCSIENLDPMGVHTGDSVTVAPSMTLTDREYQILRDIGIAVIREVGVDTGGCNIQFAVDPADGRVVVIEMNPRVSRSSALASKATGFPIAKIAAKLAVGYTLDEIPNDITRETPASFEPTLDYVVVKVPRFAFEKFPAADATLTTTMKSVGEAMAIGRNFTEALNKALRSVEKKDAPFDFAGPPPGPGEKAALLEKAAVPTDGRLNTVMAAIRAGATEAEVHEATRIDPWFVDQFFLIKEVADELAAADHLGPDLLAYAKRHGFSDAQIAGVRGLREDVVREVRHALGVRPVYKTVDTCAAEFAARTPYLYSSYDEETEVAPRERPAVIILGSGPNRIGQGIEFDYSCVHASFALGEAGYETVMVNCNPETVSTDYDTSDRLYFEPLTLEDVLEVVHAETQAGPVAGVLVQLGGQTPLGLAQALKDNGVPVVGTSPEAIHAAEDRGVFGRVLAEAGLPAPKYGTAFSFAEAKKIAAGIGYPVMVRPSYVLGGRGMEIVYDEPSLAAYLERHAGLISEHPVLVDRFLDDTIEIDVDALYDGHELYLGGVMEHIEEAGIHSGDSACALPPITLGGHDIKRLRASTEAIARGVGVRGLINIQFALAGDILYVLEANPRASRTVPFTSKATAVPLAKAAARISLGATVAELRAEGMLPATGDGGTLPLDAPISVKEAVLPWTRFRDIRGRGVDTVLGPEMRSTGEVMGIDSVFGTAYAKSQAAAYGALPTRGRAFVSVANRDKRSMVFPARELVQHGFELLATSGTAEVLRRNGIAATVVRKHSQGPGPDGERTIVQLIHDGAVDLIVNTPYGTGGRLDGYDIRTAAVARGVPCLTTVQALAAAVQGIEALTRGEVGVRSLQEHAGHLTEARAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N1P9</accession>
    <name>A0A0F7N1P9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AA958_10025</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH82510">
        <property type="protein sequence ID" value="AKH82510"/>
        <property type="gene ID" value="AA958_10025"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_10025"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2110"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AKH82510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="94" mass="10658" checksum="8F60AD554356840B" modified="2015-07-22" version="1">MVPIATLDLAGMRTLAYAAFLGQPVLAVHISISEEEERRFRAYPDLTLTAILPEVVTRHRRHQILHSRTAGRLRRGLRHLAKIVITTVPFHLPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N1Q6</accession>
    <name>A0A0F7N1Q6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Beta-galactosidase</fullName>
            <shortName evidence="5">Beta-gal</shortName>
            <ecNumber evidence="3 5">3.2.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AA958_03005</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CNQ-509</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the glycosyl hydrolase 42 family.</text>
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    <dbReference type="EnsemblBacteria" id="AKH81314">
        <property type="protein sequence ID" value="AKH81314"/>
        <property type="gene ID" value="AA958_03005"/>
    </dbReference>
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    <dbReference type="PATRIC" id="fig|444103.5.peg.641"/>
    <dbReference type="OrthoDB" id="831762at2"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009341">
        <property type="term" value="C:beta-galactosidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013739">
        <property type="entry name" value="Beta_galactosidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013738">
        <property type="entry name" value="Beta_galactosidase_Trimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003476">
        <property type="entry name" value="Glyco_hydro_42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013529">
        <property type="entry name" value="Glyco_hydro_42_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36447">
        <property type="entry name" value="PTHR36447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02449">
        <property type="entry name" value="Glyco_hydro_42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08533">
        <property type="entry name" value="Glyco_hydro_42C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08532">
        <property type="entry name" value="Glyco_hydro_42M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001084">
        <property type="entry name" value="B-galactosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Glyco_hydro_42" evidence="9">
        <location>
            <begin position="9"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_42M" evidence="10">
        <location>
            <begin position="390"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_42C" evidence="11">
        <location>
            <begin position="602"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="301"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR001084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001084-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001084-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001084-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AKH81314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="664" mass="72901" checksum="C2A7664967F0612C" modified="2015-07-22" version="1">MGRIHFGGDYNPEHWPEEVRAEDIRLMKEAGVSMVTAGIFSWALVEPRPGAYDFDWFGRVLDDLHGAGIRVCLATMTASPPPWLTEQHPEVLPQDADGVRRWPGSRQHFCPSSPVYREHAVRLVTELATRYGTHPALESWHIGNEYGCSNPRCYCDVSAADFRRWLHERYGTVEALNTAWATTFWSQRYGTFEEVFPPRTTPTFPNPAQVLDYARFCDDALLQCYLAEKEALRRITPDVPVTTNHMPLHKPVDPYAWAAHEDVQALDFYQDPYDPETHVGAALAFDVTRSAGGGRPWMLMEQAPSAVNWRARNSPKPPGTMRLWSWQAVAQGADAVLYFQWRATPGGAEKFHSAMVPHAGTDTRIFREVRALGRELAAVPQLAGARSRPEVALLADWHSWWALEQGSHPSADLDFAETLRRHYRPFFDAGVECDVVPPDRDLSAYRLVVVPNLYLMSTETGARLTEFVRAGGHLLVSYFTGISDDCDRVHLGGHPAPLREVLGLRVEEFWPLAEGQHLPLTGTLTGSGDLWSEAIDLEGAEEVAAFGAGELAGRPAVTRHAYGDGVAWYAGTRLPVAAMRALVDRVRAGAGVAPVLPGLPAGIQATVREGAEGRFLFLLNHGAGTATVTLPEPMPAVAGDGVDPAAGPVASVDLPARGVVVLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N1W1</accession>
    <name>A0A0F7N1W1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AA958_10515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_10515"/>
    <dbReference type="EnsemblBacteria" id="AKH82585">
        <property type="protein sequence ID" value="AKH82585"/>
        <property type="gene ID" value="AA958_10515"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_10515"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2215"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="484"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="507"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKH82585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="521" mass="56267" checksum="C667926DA676FC04" modified="2015-07-22" version="1">MSLMVTLARAEAVVAGRATPLATVRHRHLSDRPLVLVPMTAAGEAAAPLGALVGCARDRPRLLVVPQPRDRDLRFAFLAELAAEVLPYVESYTEDGETGETGGSGGSGRSGDTPGGGDEPAEPVQEPCADAAQLLVPSRAGVEYVRLLGRSMRFRRTAEDDPDAPHPAPPRVPLLGRWLSHYGERARVPGASLLLSATELLARHWATGQSTVEDQHLGALLAWITDGAAAAERAETGRDAEGQLLVPPAGPATDPAFDNRLLAPAMARFDRARAEGDPAATRAAEEAVARLVESRLRPTWDAVWRSYDLLRALPEGAHVPGRWLGDRWSFTAHRDRVRAGEPPQPRRDDAVTAARKLAQRERALAELDAQEALDDPLTMAERRLAGQAFVCRTESVEMAYSEGRRPMPRPLVTVATDDEPHLEDGGKVYRELPGGRTQRALVAGYGDGRVTVQLQDGMGRSRTPAEGSVPEPGDRVVWTLFEHTARRGPALPEPEDTPWTHGSPAARAAEEPDRVTAEDFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N212</accession>
    <name>A0A0F7N212_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Type-5 uracil-DNA glycosylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AA958_07105</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 5 (UDGb) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015376.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_07105"/>
    <dbReference type="EnsemblBacteria" id="AKH82026">
        <property type="protein sequence ID" value="AKH82026"/>
        <property type="gene ID" value="AA958_07105"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_07105"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1489"/>
    <dbReference type="OrthoDB" id="1529383at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033958">
        <property type="term" value="F:DNA-deoxyinosine glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004844">
        <property type="term" value="F:uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10031">
        <property type="entry name" value="UDG-F5_TTUDGB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044147">
        <property type="entry name" value="UdgB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="SSF52141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDG" evidence="10">
        <location>
            <begin position="61"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AKH82026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="248" mass="26614" checksum="F4A56A674789A3DF" modified="2015-07-22" version="1">MTTTEPPLPAVTAPRTRTVAELDGRLCECRSCPRLVAWREEVAATKRKAYADWDYWGRPVPGFGPADAAMLIIGLAPAAHGGNRTGRMFTGDRSGDVLYAALHATGFASRPTATHRGDGLTLRGVRITAPVHCAPPENKPTPTERDTCRPWLVREIELLRPTLRSAVVLGSFGWQAALPVLAAAGWEVPRPRPVFGHGAHTTLRRPDGGAPLELYGCYHVSQQNTFTGRLTPAMLREVLAAAGAAAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N264</accession>
    <name>A0A0F7N264_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LacI family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AA958_07470</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047015446.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AKH82096">
        <property type="protein sequence ID" value="AKH82096"/>
        <property type="gene ID" value="AA958_07470"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_07470"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.1566"/>
    <dbReference type="OrthoDB" id="664909at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="21"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AKH82096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="355" mass="37671" checksum="72F113A18E592DEF" modified="2015-07-22" version="1">MTKIIGRAESRSVTGIRTPRPTLAQIAETAGVSISTVSKVLNGRDDVSTDTRAKVDSALRQHQYTRRGVSLSASAVRALDLVMSGLDGSWPASVASGLEAAAYEAGVHVVISAARSGASANNRGAQDWVDRVVERGSAGVVLGLIEPTPHQLTRLRQARIPIVVIDPLSDPPPDVVSVGTTNWAGAYEATTHLLDRGHRRIALVTGPPHHLYARARTAGYRSAMSAAGIDGDPAMIRYGTYDRASGAEQVRALCELPEPPTALFICSDHMAIGGYEALAAAGLRVPEDVSVVGFDDLPEARWVSPALTTVRQPLKDMGGSALRTLLRLMNGDEPESPRVELATTLVVRDSTAHRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N296</accession>
    <name>A0A0F7N296_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Mannose-6-phosphate isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AA958_11350</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PGI/PMI family.</text>
    </comment>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016062.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_11350"/>
    <dbReference type="EnsemblBacteria" id="AKH82725">
        <property type="protein sequence ID" value="AKH82725"/>
        <property type="gene ID" value="AA958_11350"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_11350"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2388"/>
    <dbReference type="OrthoDB" id="1179564at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004347">
        <property type="term" value="F:glucose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004476">
        <property type="term" value="F:mannose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019490">
        <property type="entry name" value="Glu6P/Mann6P_isomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10432">
        <property type="entry name" value="bact-PGI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="bact-PGI_C" evidence="3">
        <location>
            <begin position="220"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="316"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH82725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="373" mass="38487" checksum="F5B33B8BE6CE8C2C" modified="2015-07-22" version="1">MLDESLLDDPGALARADARGLLRSVAQAGAQTRIAARQAAESDLARVRPDGRPRAVLVAAPGPVANTTADLLRALTAGASPVAALRPTGARPEPSALNWTLPGWAGPYDLLLIATDYGREPGLTALVEQAYRRGCTVAAVAPRTSAVTEIATSRGLAMPLLSAPGEQIETGGLWPLLTPLLALADRIDLIDAPDEALSRVADRLDIVAERCGPAIETYANPAKTLAAELAESLPLLWSEGPVAGVAARYFARQLAAVAGRPALPATLPDALAAHGMLLSGAFTSGADPDDIFRDRVEEPAALRARIVLLHDESADTARTPREAAPAVRELASAQGTPVSELEPSDGDPLEAAGELIATADFTAVYLALAAGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2A9</accession>
    <name>A0A0F7N2A9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphoenolpyruvate transferase</fullName>
            <ecNumber evidence="3">2.7.8.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">EPPG:FO PEP transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">fbiA</name>
        <name evidence="4" type="ORF">AA958_11400</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CNQ-509</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the transfer of the phosphoenolpyruvate moiety from enoylpyruvoyl-2-diphospho-5'-guanosine (EPPG) to 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) with the formation of dehydro coenzyme F420-0 and GMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>7,8-didemethyl-8-hydroxy-5-deazariboflavin + enolpyruvoyl-2-diphospho-5'-guanosine = dehydro coenzyme F420-0 + GMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27510"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:59904"/>
            <dbReference type="ChEBI" id="CHEBI:143701"/>
            <dbReference type="ChEBI" id="CHEBI:143705"/>
            <dbReference type="EC" id="2.7.8.28"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; coenzyme F420 biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CofD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.28" evidence="3"/>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH82735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047016071.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_11400"/>
    <dbReference type="EnsemblBacteria" id="AKH82735">
        <property type="protein sequence ID" value="AKH82735"/>
        <property type="gene ID" value="AA958_11400"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_11400"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.2399"/>
    <dbReference type="OrthoDB" id="1079756at2"/>
    <dbReference type="UniPathway" id="UPA00071"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043743">
        <property type="term" value="F:LPPG:FO 2-phospho-L-lactate transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052645">
        <property type="term" value="P:F420-0 metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07186">
        <property type="entry name" value="CofD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10680">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01257">
        <property type="entry name" value="CofD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002882">
        <property type="entry name" value="CofD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038136">
        <property type="entry name" value="CofD-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010115">
        <property type="entry name" value="FbiA/CofD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43007">
        <property type="entry name" value="PTHR43007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01933">
        <property type="entry name" value="CofD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142338">
        <property type="entry name" value="SSF142338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01819">
        <property type="entry name" value="F420_cofD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3 4" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>7,8-didemethyl-8-hydroxy-5-deazariboflavin</name>
            <dbReference type="ChEBI" id="CHEBI:59904"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AKH82735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="318" mass="33247" checksum="3B997DBE327F2725" modified="2015-07-22" version="1">MRIVVLAGGIGGARFLRGLKQAEPDADVTVVGNTGDDIHLFGLKVCPDLDTVMYTLGGGIHEEQGWGRADETFAVREELAAYGVGPGWFGLGDRDFATHIVRTQMLGAGFPLSAVTEALCDRWRPGVRLVPMTDDRVETHVAVEVDGERKAIHFQEYWVRLRASVPALAVVPVGAEQAKPAPGVLEAIAEADVVLFPPSNPVVSIGTILAVPGIREAIADADVPVVGLSPIVGGAPVRGMADKVLAAVGVESTADAVALHYGSGLIDGWLVDEVDAAAVPAVEAAGIRCRAVPLMMRDTDATARMAAAALELAQEVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2G0</accession>
    <name>A0A0F7N2G0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_04470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_04470"/>
    <dbReference type="EnsemblBacteria" id="AKH81568">
        <property type="protein sequence ID" value="AKH81568"/>
        <property type="gene ID" value="AA958_04470"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_04470"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.943"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002519092" evidence="1">
        <location>
            <begin position="34"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="2">
        <location>
            <begin position="96"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKH81568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000034283"/>
        </source>
    </evidence>
    <sequence length="543" mass="58583" checksum="E217BDEDA384F251" modified="2015-07-22" version="1">MSDVSPEPGVDRRRVLQYGGALSAFGVMAPALAACSGGPDSTSDTGGGGGGDSVTAVIGYGNDQSWDPTLTASAFSVAANHHIFEGLLDTDPITREPYPALATELPADTGAGTWSFTLRSGATWHDGKPVTADDVVFTFDRILDTETQTLAHGFFAGWLKEVKKTGDDTVDLVLAFPFPDGLSRLTLAKILPKHILGKSGAWKDLDTGLPEVTVGSGPYRMTANQPLSNTSFEAYADYNGPRKANFKKMNWLSIVDAAPRVAKISGGSAGAQISDNIPYANVKQLEQDGLTVEGGAGMNHMFLLFNTERAPFDDVRVRQALHYAIDTDKMIEAGLKGYGKAASSFLDEGNPTYRKAKTVYGHDPDKAKALLEDAGVSGLKVTLMASTVSWIADCIPTIKESWDAIGVETTLEPQETSALFTKLDQKANYQVVASASNPNQLGIDADLILRYNYTAENVWMDYARWSQASEAKQLFRLMDAATREPDQEKKKQMTQEYLDVIAENAVIYPVVHTELVTAWDDGKITGIQPQPYPGINLLKAKPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-07-22" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0F7N2I5</accession>
    <name>A0A0F7N2I5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AA958_04610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CNQ-509</name>
        <dbReference type="NCBI Taxonomy" id="444103"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-05" db="EMBL/GenBank/DDBJ databases">
            <title>Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.</title>
            <authorList>
                <person name="Ruckert C."/>
                <person name="Albersmeier A."/>
                <person name="Leipoldt F."/>
                <person name="Winkler A."/>
                <person name="Zeyhle P."/>
                <person name="Kalinowski J."/>
                <person name="Heide L."/>
                <person name="Kaysser L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CNQ-509</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP011492">
        <property type="protein sequence ID" value="AKH81594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047014949.1">
        <property type="nucleotide sequence ID" value="NZ_CP011492.1"/>
    </dbReference>
    <dbReference type="STRING" id="444103.AA958_04610"/>
    <dbReference type="EnsemblBacteria" id="AKH81594">
        <property type="protein sequence ID" value="AKH81594"/>
        <property type="gene ID" value="AA958_04610"/>
    </dbReference>
    <dbReference type="KEGG" id="strc:AA958_04610"/>
    <dbReference type="PATRIC" id="fig|444103.5.peg.972"/>
    <dbReference type="OrthoDB" id="703516at2"/>
    <dbReference type="Proteomes" id="UP000034283">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041635">
        <property type="entry name" value="Type_ISP_LLaBIII_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18135">
        <property type="entry name" value="Type_ISP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Type_ISP_C" evidence="2">
        <location>
            <begin position="74"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="451"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="E
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